HEADER VIRAL PROTEIN 20-FEB-25 9LYO TITLE ALPHA SARS-COV-2 SPIKE PROTEIN IN COMPLEX WITH REGN10987 FAB TITLE 2 HOMOLOGUE. COMPND MOL_ID: 1; COMPND 2 MOLECULE: REGN10987 FAB HOMOLOGUE (LIGHT CHAIN); COMPND 3 CHAIN: i, g, l; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: REGN10987 FAB HOMOLOGUE (HEAVY CHAIN); COMPND 7 CHAIN: j, h, n; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 11 CHAIN: A, B, C; COMPND 12 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 13 2; SOURCE 14 ORGANISM_TAXID: 2697049; SOURCE 15 GENE: S, 2; SOURCE 16 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR M.V.KOCHAROVSKAYA,E.B.PICHKUR,Z.O.SHENKAREV,E.N.LYUKMANOVA REVDAT 1 02-APR-25 9LYO 0 JRNL AUTH M.V.KOCHAROVSKAYA,E.B.PICHKUR,A.D.IVANNIKOV, JRNL AUTH 2 D.D.KHARLAMPIEVA,E.N.GRAFSKAIA,E.N.LYUKMANOVA, JRNL AUTH 3 M.P.KIRPICHNIKOV,Z.O.SHENKAREV JRNL TITL STRUCTURE AND DYNAMICS OF ALPHA B.1.1.7 SARS-COV-2 S-PROTEIN JRNL TITL 2 IN COMPLEX WITH FAB OF NEUTRALIZING ANTIBODY REGN10987. JRNL REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 755 51558 2025 JRNL REFN ESSN 1090-2104 JRNL PMID 40043614 JRNL DOI 10.1016/J.BBRC.2025.151558 REMARK 2 REMARK 2 RESOLUTION. 3.07 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.070 REMARK 3 NUMBER OF PARTICLES : 34988 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9LYO COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 21-FEB-25. REMARK 100 THE DEPOSITION ID IS D_1300056411. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : ALPHA SARS-COV-2 S-PROTEIN + REMARK 245 REGN10987 FAB HOMOLOGUE; REMARK 245 REGN10987 FAB HOMOLOGUE; ALPHA REMARK 245 SARS-COV-2 S-PROTEIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1600.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : SPOT SCAN REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: i, j, A, B, C, g, h, l, n, P, REMARK 350 AND CHAINS: D, E, F, G, H, I, J, K, L, REMARK 350 AND CHAINS: M, N, O, Q, R, S, T, U, V, W, REMARK 350 AND CHAINS: X, Y, Z, a, b, c, d, e, f, REMARK 350 AND CHAINS: k, m REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -2 REMARK 465 GLU A -1 REMARK 465 THR A 0 REMARK 465 ASP A 1 REMARK 465 THR A 2 REMARK 465 LEU A 3 REMARK 465 LEU A 4 REMARK 465 LEU A 5 REMARK 465 TRP A 6 REMARK 465 VAL A 7 REMARK 465 LEU A 8 REMARK 465 LEU A 9 REMARK 465 LEU A 10 REMARK 465 TRP A 11 REMARK 465 VAL A 12 REMARK 465 PRO A 13 REMARK 465 GLY A 14 REMARK 465 SER A 15 REMARK 465 THR A 16 REMARK 465 GLY A 17 REMARK 465 ASP A 18 REMARK 465 VAL A 19 REMARK 465 ASN A 20 REMARK 465 LEU A 21 REMARK 465 THR A 22 REMARK 465 THR A 23 REMARK 465 ARG A 24 REMARK 465 THR A 25 REMARK 465 GLN A 26 REMARK 465 LEU A 27 REMARK 465 PRO A 28 REMARK 465 PRO A 29 REMARK 465 ALA A 70 REMARK 465 ILE A 71 REMARK 465 SER A 72 REMARK 465 GLY A 73 REMARK 465 THR A 74 REMARK 465 ASN A 75 REMARK 465 GLY A 76 REMARK 465 THR A 77 REMARK 465 LYS A 78 REMARK 465 ARG A 79 REMARK 465 PHE A 80 REMARK 465 ASP A 81 REMARK 465 TYR A 145 REMARK 465 HIS A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 MET A 153 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLN A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 PHE A 186 REMARK 465 HIS A 245 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 ALA A 262 REMARK 465 VAL A 622 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 TYR A 636 REMARK 465 SER A 637 REMARK 465 THR A 638 REMARK 465 THR A 678 REMARK 465 ASN A 679 REMARK 465 SER A 680 REMARK 465 HIS A 681 REMARK 465 ARG A 682 REMARK 465 ALA A 683 REMARK 465 ALA A 684 REMARK 465 ALA A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 GLU A 1209 REMARK 465 PHE A 1210 REMARK 465 GLY A 1211 REMARK 465 SER A 1212 REMARK 465 GLY A 1213 REMARK 465 GLY A 1214 REMARK 465 TYR A 1215 REMARK 465 ILE A 1216 REMARK 465 PRO A 1217 REMARK 465 GLU A 1218 REMARK 465 ALA A 1219 REMARK 465 PRO A 1220 REMARK 465 ARG A 1221 REMARK 465 ASP A 1222 REMARK 465 GLY A 1223 REMARK 465 GLN A 1224 REMARK 465 ALA A 1225 REMARK 465 TYR A 1226 REMARK 465 VAL A 1227 REMARK 465 ARG A 1228 REMARK 465 LYS A 1229 REMARK 465 ASP A 1230 REMARK 465 GLY A 1231 REMARK 465 GLU A 1232 REMARK 465 TRP A 1233 REMARK 465 VAL A 1234 REMARK 465 LEU A 1235 REMARK 465 LEU A 1236 REMARK 465 SER A 1237 REMARK 465 THR A 1238 REMARK 465 PHE A 1239 REMARK 465 LEU A 1240 REMARK 465 LYS A 1241 REMARK 465 GLY A 1242 REMARK 465 GLN A 1243 REMARK 465 ASP A 1244 REMARK 465 ASN A 1245 REMARK 465 SER A 1246 REMARK 465 ALA A 1247 REMARK 465 ASP A 1248 REMARK 465 ILE A 1249 REMARK 465 GLN A 1250 REMARK 465 HIS A 1251 REMARK 465 SER A 1252 REMARK 465 GLY A 1253 REMARK 465 ARG A 1254 REMARK 465 PRO A 1255 REMARK 465 LEU A 1256 REMARK 465 GLU A 1257 REMARK 465 SER A 1258 REMARK 465 ARG A 1259 REMARK 465 GLY A 1260 REMARK 465 PRO A 1261 REMARK 465 PHE A 1262 REMARK 465 GLU A 1263 REMARK 465 GLN A 1264 REMARK 465 LYS A 1265 REMARK 465 LEU A 1266 REMARK 465 ILE A 1267 REMARK 465 SER A 1268 REMARK 465 GLU A 1269 REMARK 465 GLU A 1270 REMARK 465 ASP A 1271 REMARK 465 LEU A 1272 REMARK 465 ASN A 1273 REMARK 465 MET A 1274 REMARK 465 HIS A 1275 REMARK 465 THR A 1276 REMARK 465 GLY A 1277 REMARK 465 HIS A 1278 REMARK 465 HIS A 1279 REMARK 465 HIS A 1280 REMARK 465 HIS A 1281 REMARK 465 HIS A 1282 REMARK 465 HIS A 1283 REMARK 465 MET B -2 REMARK 465 GLU B -1 REMARK 465 THR B 0 REMARK 465 ASP B 1 REMARK 465 THR B 2 REMARK 465 LEU B 3 REMARK 465 LEU B 4 REMARK 465 LEU B 5 REMARK 465 TRP B 6 REMARK 465 VAL B 7 REMARK 465 LEU B 8 REMARK 465 LEU B 9 REMARK 465 LEU B 10 REMARK 465 TRP B 11 REMARK 465 VAL B 12 REMARK 465 PRO B 13 REMARK 465 GLY B 14 REMARK 465 SER B 15 REMARK 465 THR B 16 REMARK 465 GLY B 17 REMARK 465 ASP B 18 REMARK 465 VAL B 19 REMARK 465 ASN B 20 REMARK 465 LEU B 21 REMARK 465 THR B 22 REMARK 465 THR B 23 REMARK 465 ARG B 24 REMARK 465 THR B 25 REMARK 465 GLN B 26 REMARK 465 LEU B 27 REMARK 465 PRO B 28 REMARK 465 PRO B 29 REMARK 465 ALA B 70 REMARK 465 ILE B 71 REMARK 465 SER B 72 REMARK 465 GLY B 73 REMARK 465 THR B 74 REMARK 465 ASN B 75 REMARK 465 GLY B 76 REMARK 465 THR B 77 REMARK 465 LYS B 78 REMARK 465 ARG B 79 REMARK 465 PHE B 80 REMARK 465 ASP B 81 REMARK 465 TYR B 145 REMARK 465 HIS B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASN B 149 REMARK 465 LYS B 150 REMARK 465 SER B 151 REMARK 465 TRP B 152 REMARK 465 MET B 153 REMARK 465 GLU B 154 REMARK 465 MET B 177 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLN B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 PHE B 186 REMARK 465 ALA B 243 REMARK 465 LEU B 244 REMARK 465 HIS B 245 REMARK 465 ARG B 246 REMARK 465 SER B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 GLY B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 SER B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 TRP B 258 REMARK 465 THR B 259 REMARK 465 ALA B 260 REMARK 465 GLY B 261 REMARK 465 ALA B 262 REMARK 465 VAL B 622 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 TYR B 636 REMARK 465 SER B 637 REMARK 465 THR B 638 REMARK 465 THR B 676 REMARK 465 GLN B 677 REMARK 465 THR B 678 REMARK 465 ASN B 679 REMARK 465 SER B 680 REMARK 465 HIS B 681 REMARK 465 ARG B 682 REMARK 465 ALA B 683 REMARK 465 ALA B 684 REMARK 465 ALA B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 SER B 689 REMARK 465 GLN B 690 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 SER B 1147 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 GLU B 1209 REMARK 465 PHE B 1210 REMARK 465 GLY B 1211 REMARK 465 SER B 1212 REMARK 465 GLY B 1213 REMARK 465 GLY B 1214 REMARK 465 TYR B 1215 REMARK 465 ILE B 1216 REMARK 465 PRO B 1217 REMARK 465 GLU B 1218 REMARK 465 ALA B 1219 REMARK 465 PRO B 1220 REMARK 465 ARG B 1221 REMARK 465 ASP B 1222 REMARK 465 GLY B 1223 REMARK 465 GLN B 1224 REMARK 465 ALA B 1225 REMARK 465 TYR B 1226 REMARK 465 VAL B 1227 REMARK 465 ARG B 1228 REMARK 465 LYS B 1229 REMARK 465 ASP B 1230 REMARK 465 GLY B 1231 REMARK 465 GLU B 1232 REMARK 465 TRP B 1233 REMARK 465 VAL B 1234 REMARK 465 LEU B 1235 REMARK 465 LEU B 1236 REMARK 465 SER B 1237 REMARK 465 THR B 1238 REMARK 465 PHE B 1239 REMARK 465 LEU B 1240 REMARK 465 LYS B 1241 REMARK 465 GLY B 1242 REMARK 465 GLN B 1243 REMARK 465 ASP B 1244 REMARK 465 ASN B 1245 REMARK 465 SER B 1246 REMARK 465 ALA B 1247 REMARK 465 ASP B 1248 REMARK 465 ILE B 1249 REMARK 465 GLN B 1250 REMARK 465 HIS B 1251 REMARK 465 SER B 1252 REMARK 465 GLY B 1253 REMARK 465 ARG B 1254 REMARK 465 PRO B 1255 REMARK 465 LEU B 1256 REMARK 465 GLU B 1257 REMARK 465 SER B 1258 REMARK 465 ARG B 1259 REMARK 465 GLY B 1260 REMARK 465 PRO B 1261 REMARK 465 PHE B 1262 REMARK 465 GLU B 1263 REMARK 465 GLN B 1264 REMARK 465 LYS B 1265 REMARK 465 LEU B 1266 REMARK 465 ILE B 1267 REMARK 465 SER B 1268 REMARK 465 GLU B 1269 REMARK 465 GLU B 1270 REMARK 465 ASP B 1271 REMARK 465 LEU B 1272 REMARK 465 ASN B 1273 REMARK 465 MET B 1274 REMARK 465 HIS B 1275 REMARK 465 THR B 1276 REMARK 465 GLY B 1277 REMARK 465 HIS B 1278 REMARK 465 HIS B 1279 REMARK 465 HIS B 1280 REMARK 465 HIS B 1281 REMARK 465 HIS B 1282 REMARK 465 HIS B 1283 REMARK 465 MET C -2 REMARK 465 GLU C -1 REMARK 465 THR C 0 REMARK 465 ASP C 1 REMARK 465 THR C 2 REMARK 465 LEU C 3 REMARK 465 LEU C 4 REMARK 465 LEU C 5 REMARK 465 TRP C 6 REMARK 465 VAL C 7 REMARK 465 LEU C 8 REMARK 465 LEU C 9 REMARK 465 LEU C 10 REMARK 465 TRP C 11 REMARK 465 VAL C 12 REMARK 465 PRO C 13 REMARK 465 GLY C 14 REMARK 465 SER C 15 REMARK 465 THR C 16 REMARK 465 GLY C 17 REMARK 465 ASP C 18 REMARK 465 VAL C 19 REMARK 465 ASN C 20 REMARK 465 LEU C 21 REMARK 465 THR C 22 REMARK 465 THR C 23 REMARK 465 ARG C 24 REMARK 465 THR C 25 REMARK 465 GLN C 26 REMARK 465 LEU C 27 REMARK 465 PRO C 28 REMARK 465 PRO C 29 REMARK 465 ALA C 70 REMARK 465 ILE C 71 REMARK 465 SER C 72 REMARK 465 GLY C 73 REMARK 465 THR C 74 REMARK 465 ASN C 75 REMARK 465 GLY C 76 REMARK 465 THR C 77 REMARK 465 LYS C 78 REMARK 465 ARG C 79 REMARK 465 PHE C 80 REMARK 465 ASP C 81 REMARK 465 GLY C 143 REMARK 465 VAL C 144 REMARK 465 TYR C 145 REMARK 465 HIS C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 MET C 153 REMARK 465 GLU C 154 REMARK 465 MET C 177 REMARK 465 ASP C 178 REMARK 465 LEU C 179 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLN C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 PHE C 186 REMARK 465 LEU C 212 REMARK 465 VAL C 213 REMARK 465 ARG C 214 REMARK 465 ASP C 215 REMARK 465 LEU C 216 REMARK 465 ALA C 243 REMARK 465 LEU C 244 REMARK 465 HIS C 245 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 GLY C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 GLY C 261 REMARK 465 ALA C 262 REMARK 465 VAL C 622 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 TYR C 636 REMARK 465 SER C 637 REMARK 465 THR C 638 REMARK 465 GLY C 639 REMARK 465 SER C 640 REMARK 465 THR C 676 REMARK 465 GLN C 677 REMARK 465 THR C 678 REMARK 465 ASN C 679 REMARK 465 SER C 680 REMARK 465 HIS C 681 REMARK 465 ARG C 682 REMARK 465 ALA C 683 REMARK 465 ALA C 684 REMARK 465 ALA C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 SER C 689 REMARK 465 GLN C 690 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 SER C 1147 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 GLU C 1209 REMARK 465 PHE C 1210 REMARK 465 GLY C 1211 REMARK 465 SER C 1212 REMARK 465 GLY C 1213 REMARK 465 GLY C 1214 REMARK 465 TYR C 1215 REMARK 465 ILE C 1216 REMARK 465 PRO C 1217 REMARK 465 GLU C 1218 REMARK 465 ALA C 1219 REMARK 465 PRO C 1220 REMARK 465 ARG C 1221 REMARK 465 ASP C 1222 REMARK 465 GLY C 1223 REMARK 465 GLN C 1224 REMARK 465 ALA C 1225 REMARK 465 TYR C 1226 REMARK 465 VAL C 1227 REMARK 465 ARG C 1228 REMARK 465 LYS C 1229 REMARK 465 ASP C 1230 REMARK 465 GLY C 1231 REMARK 465 GLU C 1232 REMARK 465 TRP C 1233 REMARK 465 VAL C 1234 REMARK 465 LEU C 1235 REMARK 465 LEU C 1236 REMARK 465 SER C 1237 REMARK 465 THR C 1238 REMARK 465 PHE C 1239 REMARK 465 LEU C 1240 REMARK 465 LYS C 1241 REMARK 465 GLY C 1242 REMARK 465 GLN C 1243 REMARK 465 ASP C 1244 REMARK 465 ASN C 1245 REMARK 465 SER C 1246 REMARK 465 ALA C 1247 REMARK 465 ASP C 1248 REMARK 465 ILE C 1249 REMARK 465 GLN C 1250 REMARK 465 HIS C 1251 REMARK 465 SER C 1252 REMARK 465 GLY C 1253 REMARK 465 ARG C 1254 REMARK 465 PRO C 1255 REMARK 465 LEU C 1256 REMARK 465 GLU C 1257 REMARK 465 SER C 1258 REMARK 465 ARG C 1259 REMARK 465 GLY C 1260 REMARK 465 PRO C 1261 REMARK 465 PHE C 1262 REMARK 465 GLU C 1263 REMARK 465 GLN C 1264 REMARK 465 LYS C 1265 REMARK 465 LEU C 1266 REMARK 465 ILE C 1267 REMARK 465 SER C 1268 REMARK 465 GLU C 1269 REMARK 465 GLU C 1270 REMARK 465 ASP C 1271 REMARK 465 LEU C 1272 REMARK 465 ASN C 1273 REMARK 465 MET C 1274 REMARK 465 HIS C 1275 REMARK 465 THR C 1276 REMARK 465 GLY C 1277 REMARK 465 HIS C 1278 REMARK 465 HIS C 1279 REMARK 465 HIS C 1280 REMARK 465 HIS C 1281 REMARK 465 HIS C 1282 REMARK 465 HIS C 1283 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A1082 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 VAL i 29 -29.07 -141.31 REMARK 500 TYR i 51 -144.26 -144.78 REMARK 500 SER i 82 -7.89 72.53 REMARK 500 ASN i 156 15.03 59.51 REMARK 500 ASP i 174 7.85 -150.78 REMARK 500 TYR j 32 -103.59 -88.99 REMARK 500 LYS j 136 0.64 -67.67 REMARK 500 SER j 137 -76.83 -121.98 REMARK 500 THR j 167 28.68 -72.92 REMARK 500 ASN A 88 -73.53 -63.91 REMARK 500 GLU A 97 -77.94 -94.41 REMARK 500 LYS A 98 -6.04 52.97 REMARK 500 SER A 99 12.41 -148.87 REMARK 500 ASN A 100 -96.64 61.86 REMARK 500 ILE A 101 -71.25 67.15 REMARK 500 THR A 115 135.09 72.93 REMARK 500 ALA A 124 -5.66 73.90 REMARK 500 ASP A 139 78.36 56.47 REMARK 500 SER A 161 -123.00 45.79 REMARK 500 ASN A 164 -158.58 -155.25 REMARK 500 GLN A 173 81.40 52.91 REMARK 500 ASP A 198 47.64 34.98 REMARK 500 ASP A 215 -167.58 -161.91 REMARK 500 GLN A 218 -169.45 -78.97 REMARK 500 ASP A 287 164.18 174.90 REMARK 500 SER A 316 170.03 174.60 REMARK 500 PRO A 337 48.38 -83.37 REMARK 500 ASN A 536 -4.38 73.11 REMARK 500 ASN A 710 10.73 -142.81 REMARK 500 CYS A 743 118.82 -162.12 REMARK 500 ASP A 745 18.79 40.11 REMARK 500 SER A 758 35.47 -99.12 REMARK 500 CYS A 760 -7.86 -56.20 REMARK 500 SER A 816 59.68 -94.50 REMARK 500 PHE A 817 -69.55 63.63 REMARK 500 GLN A1071 130.71 -32.85 REMARK 500 HIS A1083 -152.62 -148.33 REMARK 500 ASP A1084 74.96 -65.71 REMARK 500 THR B 36 22.48 -141.87 REMARK 500 ASN B 100 -174.30 61.73 REMARK 500 ILE B 101 60.20 66.10 REMARK 500 THR B 115 -142.81 63.44 REMARK 500 ALA B 124 -3.08 70.70 REMARK 500 PRO B 140 48.13 -80.65 REMARK 500 ASN B 164 -168.37 -127.95 REMARK 500 SER B 172 -169.70 -163.85 REMARK 500 LEU B 226 87.91 -152.34 REMARK 500 ASP B 287 161.21 173.49 REMARK 500 ASN B 331 86.34 -61.59 REMARK 500 ILE B 332 121.04 -34.29 REMARK 500 REMARK 500 THIS ENTRY HAS 111 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 610 REMARK 610 MISSING HETEROATOM REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 610 I=INSERTION CODE): REMARK 610 M RES C SSEQI REMARK 610 NAG A 1305 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-63513 RELATED DB: EMDB REMARK 900 ALPHA SARS-COV-2 SPIKE PROTEIN IN COMPLEX WITH REGN10987 FAB REMARK 900 HOMOLOGUE. DBREF 9LYO i 1 218 PDB 9LYO 9LYO 1 218 DBREF 9LYO j 1 223 PDB 9LYO 9LYO 1 223 DBREF 9LYO A 19 1208 UNP P0DTC2 SPIKE_SARS2 16 1208 DBREF 9LYO B 19 1208 UNP P0DTC2 SPIKE_SARS2 16 1208 DBREF 9LYO C 19 1208 UNP P0DTC2 SPIKE_SARS2 16 1208 DBREF 9LYO g 1 218 PDB 9LYO 9LYO 1 218 DBREF 9LYO h 1 223 PDB 9LYO 9LYO 1 223 DBREF 9LYO l 1 218 PDB 9LYO 9LYO 1 218 DBREF 9LYO n 1 223 PDB 9LYO 9LYO 1 223 SEQADV 9LYO MET A -2 UNP P0DTC2 INITIATING METHIONINE SEQADV 9LYO GLU A -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR A 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP A 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR A 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP A 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL A 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP A 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL A 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO A 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 14 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER A 15 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR A 16 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 17 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP A 18 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO A UNP P0DTC2 HIS 69 DELETION SEQADV 9LYO A UNP P0DTC2 VAL 70 DELETION SEQADV 9LYO A UNP P0DTC2 TYR 144 DELETION SEQADV 9LYO TYR A 501 UNP P0DTC2 ASN 501 CONFLICT SEQADV 9LYO ASP A 570 UNP P0DTC2 ALA 570 CONFLICT SEQADV 9LYO GLY A 614 UNP P0DTC2 ASP 614 CONFLICT SEQADV 9LYO HIS A 681 UNP P0DTC2 PRO 681 CONFLICT SEQADV 9LYO ALA A 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9LYO ALA A 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9LYO ILE A 716 UNP P0DTC2 THR 716 CONFLICT SEQADV 9LYO ALA A 982 UNP P0DTC2 SER 982 CONFLICT SEQADV 9LYO PRO A 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9LYO PRO A 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9LYO HIS A 1118 UNP P0DTC2 ASP 1118 CONFLICT SEQADV 9LYO GLU A 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE A 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER A 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TYR A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TYR A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASN A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO A 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE A 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU A 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN A 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS A 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE A 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER A 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU A 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU A 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP A 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU A 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASN A 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO MET A 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR A 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY A 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS A 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO MET B -2 UNP P0DTC2 INITIATING METHIONINE SEQADV 9LYO GLU B -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR B 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP B 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR B 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP B 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL B 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP B 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL B 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO B 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 14 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER B 15 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR B 16 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 17 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP B 18 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO B UNP P0DTC2 HIS 69 DELETION SEQADV 9LYO B UNP P0DTC2 VAL 70 DELETION SEQADV 9LYO B UNP P0DTC2 TYR 144 DELETION SEQADV 9LYO TYR B 501 UNP P0DTC2 ASN 501 CONFLICT SEQADV 9LYO ASP B 570 UNP P0DTC2 ALA 570 CONFLICT SEQADV 9LYO GLY B 614 UNP P0DTC2 ASP 614 CONFLICT SEQADV 9LYO HIS B 681 UNP P0DTC2 PRO 681 CONFLICT SEQADV 9LYO ALA B 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9LYO ALA B 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9LYO ILE B 716 UNP P0DTC2 THR 716 CONFLICT SEQADV 9LYO ALA B 982 UNP P0DTC2 SER 982 CONFLICT SEQADV 9LYO PRO B 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9LYO PRO B 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9LYO HIS B 1118 UNP P0DTC2 ASP 1118 CONFLICT SEQADV 9LYO GLU B 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE B 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER B 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TYR B 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE B 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO B 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU B 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA B 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO B 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG B 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP B 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN B 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA B 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TYR B 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL B 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG B 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS B 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP B 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU B 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP B 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL B 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER B 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR B 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE B 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS B 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN B 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP B 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASN B 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER B 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA B 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP B 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE B 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN B 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER B 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG B 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO B 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU B 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER B 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG B 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO B 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE B 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU B 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN B 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS B 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE B 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER B 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU B 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU B 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP B 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU B 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASN B 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO MET B 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR B 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY B 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS B 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO MET C -2 UNP P0DTC2 INITIATING METHIONINE SEQADV 9LYO GLU C -1 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR C 0 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP C 1 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR C 2 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 3 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 4 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 5 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP C 6 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL C 7 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 8 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 9 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 10 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP C 11 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL C 12 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO C 13 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 14 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER C 15 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR C 16 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 17 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP C 18 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO C UNP P0DTC2 HIS 69 DELETION SEQADV 9LYO C UNP P0DTC2 VAL 70 DELETION SEQADV 9LYO C UNP P0DTC2 TYR 144 DELETION SEQADV 9LYO TYR C 501 UNP P0DTC2 ASN 501 CONFLICT SEQADV 9LYO ASP C 570 UNP P0DTC2 ALA 570 CONFLICT SEQADV 9LYO GLY C 614 UNP P0DTC2 ASP 614 CONFLICT SEQADV 9LYO HIS C 681 UNP P0DTC2 PRO 681 CONFLICT SEQADV 9LYO ALA C 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9LYO ALA C 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9LYO ILE C 716 UNP P0DTC2 THR 716 CONFLICT SEQADV 9LYO ALA C 982 UNP P0DTC2 SER 982 CONFLICT SEQADV 9LYO PRO C 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9LYO PRO C 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9LYO HIS C 1118 UNP P0DTC2 ASP 1118 CONFLICT SEQADV 9LYO GLU C 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE C 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER C 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TYR C 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE C 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO C 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU C 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA C 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO C 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG C 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP C 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN C 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA C 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TYR C 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL C 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG C 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS C 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP C 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU C 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO TRP C 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO VAL C 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER C 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR C 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE C 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS C 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN C 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP C 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASN C 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER C 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ALA C 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP C 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE C 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN C 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER C 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG C 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO C 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU C 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER C 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ARG C 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PRO C 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO PHE C 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU C 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLN C 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LYS C 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ILE C 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO SER C 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU C 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLU C 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASP C 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO LEU C 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO ASN C 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO MET C 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO THR C 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO GLY C 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9LYO HIS C 1283 UNP P0DTC2 EXPRESSION TAG SEQRES 1 i 218 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 i 218 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 i 218 SER ASP VAL GLY GLY TYR ASN TYR VAL SER TRP TYR GLN SEQRES 4 i 218 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP SEQRES 5 i 218 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 i 218 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 i 218 GLY LEU GLN SER GLU ASP GLU ALA ASP TYR TYR CYS ASN SEQRES 8 i 218 SER LEU THR SER ILE SER THR TRP VAL PHE GLY GLY GLY SEQRES 9 i 218 THR LYS LEU THR VAL LEU GLY ARG THR VAL ALA ALA PRO SEQRES 10 i 218 SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SEQRES 11 i 218 SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE SEQRES 12 i 218 TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN SEQRES 13 i 218 ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU SEQRES 14 i 218 GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER THR SEQRES 15 i 218 LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL SEQRES 16 i 218 TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO SEQRES 17 i 218 VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 j 223 GLN VAL GLN LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 j 223 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 j 223 PHE THR PHE SER ASN TYR ALA MET TYR TRP VAL ARG GLN SEQRES 4 j 223 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER SEQRES 5 j 223 TYR ASP GLY SER ASN LYS TYR TYR ALA ASP SER VAL LYS SEQRES 6 j 223 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 j 223 LEU TYR LEU GLN MET ASN SER LEU ARG THR GLU ASP THR SEQRES 8 j 223 ALA VAL TYR TYR CYS ALA SER GLY SER ASP TYR GLY ASP SEQRES 9 j 223 TYR LEU LEU VAL TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 j 223 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 j 223 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 j 223 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 j 223 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 j 223 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 j 223 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 j 223 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 j 223 PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SEQRES 18 j 223 SER CYS SEQRES 1 A 1286 MET GLU THR ASP THR LEU LEU LEU TRP VAL LEU LEU LEU SEQRES 2 A 1286 TRP VAL PRO GLY SER THR GLY ASP VAL ASN LEU THR THR SEQRES 3 A 1286 ARG THR GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR SEQRES 4 A 1286 ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER SEQRES 5 A 1286 VAL LEU HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SEQRES 6 A 1286 SER ASN VAL THR TRP PHE HIS ALA ILE SER GLY THR ASN SEQRES 7 A 1286 GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN SEQRES 8 A 1286 ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE SEQRES 9 A 1286 ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS SEQRES 10 A 1286 THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL SEQRES 11 A 1286 VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO SEQRES 12 A 1286 PHE LEU GLY VAL TYR HIS LYS ASN ASN LYS SER TRP MET SEQRES 13 A 1286 GLU SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN CYS SEQRES 14 A 1286 THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP LEU SEQRES 15 A 1286 GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE SEQRES 16 A 1286 VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SER SEQRES 17 A 1286 LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN SEQRES 18 A 1286 GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE SEQRES 19 A 1286 GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA LEU SEQRES 20 A 1286 HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER GLY SEQRES 21 A 1286 TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU SEQRES 22 A 1286 GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN GLY SEQRES 23 A 1286 THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SEQRES 24 A 1286 SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL GLU SEQRES 25 A 1286 LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN PRO SEQRES 26 A 1286 THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN LEU SEQRES 27 A 1286 CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SEQRES 28 A 1286 SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN CYS SEQRES 29 A 1286 VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER PHE SEQRES 30 A 1286 SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS LEU SEQRES 31 A 1286 ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER PHE SEQRES 32 A 1286 VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY SEQRES 33 A 1286 GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO SEQRES 34 A 1286 ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER ASN SEQRES 35 A 1286 ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR LEU SEQRES 36 A 1286 TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE GLU SEQRES 37 A 1286 ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER THR SEQRES 38 A 1286 PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO SEQRES 39 A 1286 LEU GLN SER TYR GLY PHE GLN PRO THR TYR GLY VAL GLY SEQRES 40 A 1286 TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU LEU SEQRES 41 A 1286 LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SER SEQRES 42 A 1286 THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE SEQRES 43 A 1286 ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER ASN SEQRES 44 A 1286 LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE SEQRES 45 A 1286 ASP ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR LEU SEQRES 46 A 1286 GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY VAL SEQRES 47 A 1286 SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN VAL SEQRES 48 A 1286 ALA VAL LEU TYR GLN GLY VAL ASN CYS THR GLU VAL PRO SEQRES 49 A 1286 VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP ARG SEQRES 50 A 1286 VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG ALA SEQRES 51 A 1286 GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER TYR SEQRES 52 A 1286 GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SER SEQRES 53 A 1286 TYR GLN THR GLN THR ASN SER HIS ARG ALA ALA ALA SER SEQRES 54 A 1286 VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER LEU SEQRES 55 A 1286 GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER ILE SEQRES 56 A 1286 ALA ILE PRO ILE ASN PHE THR ILE SER VAL THR THR GLU SEQRES 57 A 1286 ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP CYS SEQRES 58 A 1286 THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER ASN SEQRES 59 A 1286 LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU ASN SEQRES 60 A 1286 ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS ASN SEQRES 61 A 1286 THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS SEQRES 62 A 1286 THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SER SEQRES 63 A 1286 GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SER SEQRES 64 A 1286 PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU ALA SEQRES 65 A 1286 ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY SEQRES 66 A 1286 ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE SEQRES 67 A 1286 ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP GLU SEQRES 68 A 1286 MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY THR SEQRES 69 A 1286 ILE THR SER GLY TRP THR PHE GLY ALA GLY ALA ALA LEU SEQRES 70 A 1286 GLN ILE PRO PHE ALA MET GLN MET ALA TYR ARG PHE ASN SEQRES 71 A 1286 GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN GLN SEQRES 72 A 1286 LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY LYS SEQRES 73 A 1286 ILE GLN ASP SER LEU SER SER THR ALA SER ALA LEU GLY SEQRES 74 A 1286 LYS LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU SEQRES 75 A 1286 ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY ALA SEQRES 76 A 1286 ILE SER SER VAL LEU ASN ASP ILE LEU ALA ARG LEU ASP SEQRES 77 A 1286 PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE THR SEQRES 78 A 1286 GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN GLN SEQRES 79 A 1286 LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN LEU SEQRES 80 A 1286 ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SER SEQRES 81 A 1286 LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SEQRES 82 A 1286 SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE LEU SEQRES 83 A 1286 HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE THR SEQRES 84 A 1286 THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE SEQRES 85 A 1286 PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS TRP SEQRES 86 A 1286 PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE SEQRES 87 A 1286 THR THR HIS ASN THR PHE VAL SER GLY ASN CYS ASP VAL SEQRES 88 A 1286 VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO LEU SEQRES 89 A 1286 GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP LYS SEQRES 90 A 1286 TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU GLY SEQRES 91 A 1286 ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE GLN SEQRES 92 A 1286 LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU SEQRES 93 A 1286 ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR SEQRES 94 A 1286 GLU GLN GLU PHE GLY SER GLY GLY TYR ILE PRO GLU ALA SEQRES 95 A 1286 PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU SEQRES 96 A 1286 TRP VAL LEU LEU SER THR PHE LEU LYS GLY GLN ASP ASN SEQRES 97 A 1286 SER ALA ASP ILE GLN HIS SER GLY ARG PRO LEU GLU SER SEQRES 98 A 1286 ARG GLY PRO PHE GLU GLN LYS LEU ILE SER GLU GLU ASP SEQRES 99 A 1286 LEU ASN MET HIS THR GLY HIS HIS HIS HIS HIS HIS SEQRES 1 B 1286 MET GLU THR ASP THR LEU LEU LEU TRP VAL LEU LEU LEU SEQRES 2 B 1286 TRP VAL PRO GLY SER THR GLY ASP VAL ASN LEU THR THR SEQRES 3 B 1286 ARG THR GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR SEQRES 4 B 1286 ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER SEQRES 5 B 1286 VAL LEU HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SEQRES 6 B 1286 SER ASN VAL THR TRP PHE HIS ALA ILE SER GLY THR ASN SEQRES 7 B 1286 GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN SEQRES 8 B 1286 ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE SEQRES 9 B 1286 ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS SEQRES 10 B 1286 THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL SEQRES 11 B 1286 VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO SEQRES 12 B 1286 PHE LEU GLY VAL TYR HIS LYS ASN ASN LYS SER TRP MET SEQRES 13 B 1286 GLU SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN CYS SEQRES 14 B 1286 THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP LEU SEQRES 15 B 1286 GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE SEQRES 16 B 1286 VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SER SEQRES 17 B 1286 LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN SEQRES 18 B 1286 GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE SEQRES 19 B 1286 GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA LEU SEQRES 20 B 1286 HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER GLY SEQRES 21 B 1286 TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU SEQRES 22 B 1286 GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN GLY SEQRES 23 B 1286 THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SEQRES 24 B 1286 SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL GLU SEQRES 25 B 1286 LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN PRO SEQRES 26 B 1286 THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN LEU SEQRES 27 B 1286 CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SEQRES 28 B 1286 SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN CYS SEQRES 29 B 1286 VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER PHE SEQRES 30 B 1286 SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS LEU SEQRES 31 B 1286 ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER PHE SEQRES 32 B 1286 VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY SEQRES 33 B 1286 GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO SEQRES 34 B 1286 ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER ASN SEQRES 35 B 1286 ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR LEU SEQRES 36 B 1286 TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE GLU SEQRES 37 B 1286 ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER THR SEQRES 38 B 1286 PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO SEQRES 39 B 1286 LEU GLN SER TYR GLY PHE GLN PRO THR TYR GLY VAL GLY SEQRES 40 B 1286 TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU LEU SEQRES 41 B 1286 LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SER SEQRES 42 B 1286 THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE SEQRES 43 B 1286 ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER ASN SEQRES 44 B 1286 LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE SEQRES 45 B 1286 ASP ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR LEU SEQRES 46 B 1286 GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY VAL SEQRES 47 B 1286 SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN VAL SEQRES 48 B 1286 ALA VAL LEU TYR GLN GLY VAL ASN CYS THR GLU VAL PRO SEQRES 49 B 1286 VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP ARG SEQRES 50 B 1286 VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG ALA SEQRES 51 B 1286 GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER TYR SEQRES 52 B 1286 GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SER SEQRES 53 B 1286 TYR GLN THR GLN THR ASN SER HIS ARG ALA ALA ALA SER SEQRES 54 B 1286 VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER LEU SEQRES 55 B 1286 GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER ILE SEQRES 56 B 1286 ALA ILE PRO ILE ASN PHE THR ILE SER VAL THR THR GLU SEQRES 57 B 1286 ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP CYS SEQRES 58 B 1286 THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER ASN SEQRES 59 B 1286 LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU ASN SEQRES 60 B 1286 ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS ASN SEQRES 61 B 1286 THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS SEQRES 62 B 1286 THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SER SEQRES 63 B 1286 GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SER SEQRES 64 B 1286 PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU ALA SEQRES 65 B 1286 ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY SEQRES 66 B 1286 ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE SEQRES 67 B 1286 ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP GLU SEQRES 68 B 1286 MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY THR SEQRES 69 B 1286 ILE THR SER GLY TRP THR PHE GLY ALA GLY ALA ALA LEU SEQRES 70 B 1286 GLN ILE PRO PHE ALA MET GLN MET ALA TYR ARG PHE ASN SEQRES 71 B 1286 GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN GLN SEQRES 72 B 1286 LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY LYS SEQRES 73 B 1286 ILE GLN ASP SER LEU SER SER THR ALA SER ALA LEU GLY SEQRES 74 B 1286 LYS LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU SEQRES 75 B 1286 ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY ALA SEQRES 76 B 1286 ILE SER SER VAL LEU ASN ASP ILE LEU ALA ARG LEU ASP SEQRES 77 B 1286 PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE THR SEQRES 78 B 1286 GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN GLN SEQRES 79 B 1286 LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN LEU SEQRES 80 B 1286 ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SER SEQRES 81 B 1286 LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SEQRES 82 B 1286 SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE LEU SEQRES 83 B 1286 HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE THR SEQRES 84 B 1286 THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE SEQRES 85 B 1286 PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS TRP SEQRES 86 B 1286 PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE SEQRES 87 B 1286 THR THR HIS ASN THR PHE VAL SER GLY ASN CYS ASP VAL SEQRES 88 B 1286 VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO LEU SEQRES 89 B 1286 GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP LYS SEQRES 90 B 1286 TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU GLY SEQRES 91 B 1286 ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE GLN SEQRES 92 B 1286 LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU SEQRES 93 B 1286 ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR SEQRES 94 B 1286 GLU GLN GLU PHE GLY SER GLY GLY TYR ILE PRO GLU ALA SEQRES 95 B 1286 PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU SEQRES 96 B 1286 TRP VAL LEU LEU SER THR PHE LEU LYS GLY GLN ASP ASN SEQRES 97 B 1286 SER ALA ASP ILE GLN HIS SER GLY ARG PRO LEU GLU SER SEQRES 98 B 1286 ARG GLY PRO PHE GLU GLN LYS LEU ILE SER GLU GLU ASP SEQRES 99 B 1286 LEU ASN MET HIS THR GLY HIS HIS HIS HIS HIS HIS SEQRES 1 C 1286 MET GLU THR ASP THR LEU LEU LEU TRP VAL LEU LEU LEU SEQRES 2 C 1286 TRP VAL PRO GLY SER THR GLY ASP VAL ASN LEU THR THR SEQRES 3 C 1286 ARG THR GLN LEU PRO PRO ALA TYR THR ASN SER PHE THR SEQRES 4 C 1286 ARG GLY VAL TYR TYR PRO ASP LYS VAL PHE ARG SER SER SEQRES 5 C 1286 VAL LEU HIS SER THR GLN ASP LEU PHE LEU PRO PHE PHE SEQRES 6 C 1286 SER ASN VAL THR TRP PHE HIS ALA ILE SER GLY THR ASN SEQRES 7 C 1286 GLY THR LYS ARG PHE ASP ASN PRO VAL LEU PRO PHE ASN SEQRES 8 C 1286 ASP GLY VAL TYR PHE ALA SER THR GLU LYS SER ASN ILE SEQRES 9 C 1286 ILE ARG GLY TRP ILE PHE GLY THR THR LEU ASP SER LYS SEQRES 10 C 1286 THR GLN SER LEU LEU ILE VAL ASN ASN ALA THR ASN VAL SEQRES 11 C 1286 VAL ILE LYS VAL CYS GLU PHE GLN PHE CYS ASN ASP PRO SEQRES 12 C 1286 PHE LEU GLY VAL TYR HIS LYS ASN ASN LYS SER TRP MET SEQRES 13 C 1286 GLU SER GLU PHE ARG VAL TYR SER SER ALA ASN ASN CYS SEQRES 14 C 1286 THR PHE GLU TYR VAL SER GLN PRO PHE LEU MET ASP LEU SEQRES 15 C 1286 GLU GLY LYS GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE SEQRES 16 C 1286 VAL PHE LYS ASN ILE ASP GLY TYR PHE LYS ILE TYR SER SEQRES 17 C 1286 LYS HIS THR PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN SEQRES 18 C 1286 GLY PHE SER ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE SEQRES 19 C 1286 GLY ILE ASN ILE THR ARG PHE GLN THR LEU LEU ALA LEU SEQRES 20 C 1286 HIS ARG SER TYR LEU THR PRO GLY ASP SER SER SER GLY SEQRES 21 C 1286 TRP THR ALA GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU SEQRES 22 C 1286 GLN PRO ARG THR PHE LEU LEU LYS TYR ASN GLU ASN GLY SEQRES 23 C 1286 THR ILE THR ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SEQRES 24 C 1286 SER GLU THR LYS CYS THR LEU LYS SER PHE THR VAL GLU SEQRES 25 C 1286 LYS GLY ILE TYR GLN THR SER ASN PHE ARG VAL GLN PRO SEQRES 26 C 1286 THR GLU SER ILE VAL ARG PHE PRO ASN ILE THR ASN LEU SEQRES 27 C 1286 CYS PRO PHE GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SEQRES 28 C 1286 SER VAL TYR ALA TRP ASN ARG LYS ARG ILE SER ASN CYS SEQRES 29 C 1286 VAL ALA ASP TYR SER VAL LEU TYR ASN SER ALA SER PHE SEQRES 30 C 1286 SER THR PHE LYS CYS TYR GLY VAL SER PRO THR LYS LEU SEQRES 31 C 1286 ASN ASP LEU CYS PHE THR ASN VAL TYR ALA ASP SER PHE SEQRES 32 C 1286 VAL ILE ARG GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY SEQRES 33 C 1286 GLN THR GLY LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO SEQRES 34 C 1286 ASP ASP PHE THR GLY CYS VAL ILE ALA TRP ASN SER ASN SEQRES 35 C 1286 ASN LEU ASP SER LYS VAL GLY GLY ASN TYR ASN TYR LEU SEQRES 36 C 1286 TYR ARG LEU PHE ARG LYS SER ASN LEU LYS PRO PHE GLU SEQRES 37 C 1286 ARG ASP ILE SER THR GLU ILE TYR GLN ALA GLY SER THR SEQRES 38 C 1286 PRO CYS ASN GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO SEQRES 39 C 1286 LEU GLN SER TYR GLY PHE GLN PRO THR TYR GLY VAL GLY SEQRES 40 C 1286 TYR GLN PRO TYR ARG VAL VAL VAL LEU SER PHE GLU LEU SEQRES 41 C 1286 LEU HIS ALA PRO ALA THR VAL CYS GLY PRO LYS LYS SER SEQRES 42 C 1286 THR ASN LEU VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE SEQRES 43 C 1286 ASN GLY LEU THR GLY THR GLY VAL LEU THR GLU SER ASN SEQRES 44 C 1286 LYS LYS PHE LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE SEQRES 45 C 1286 ASP ASP THR THR ASP ALA VAL ARG ASP PRO GLN THR LEU SEQRES 46 C 1286 GLU ILE LEU ASP ILE THR PRO CYS SER PHE GLY GLY VAL SEQRES 47 C 1286 SER VAL ILE THR PRO GLY THR ASN THR SER ASN GLN VAL SEQRES 48 C 1286 ALA VAL LEU TYR GLN GLY VAL ASN CYS THR GLU VAL PRO SEQRES 49 C 1286 VAL ALA ILE HIS ALA ASP GLN LEU THR PRO THR TRP ARG SEQRES 50 C 1286 VAL TYR SER THR GLY SER ASN VAL PHE GLN THR ARG ALA SEQRES 51 C 1286 GLY CYS LEU ILE GLY ALA GLU HIS VAL ASN ASN SER TYR SEQRES 52 C 1286 GLU CYS ASP ILE PRO ILE GLY ALA GLY ILE CYS ALA SER SEQRES 53 C 1286 TYR GLN THR GLN THR ASN SER HIS ARG ALA ALA ALA SER SEQRES 54 C 1286 VAL ALA SER GLN SER ILE ILE ALA TYR THR MET SER LEU SEQRES 55 C 1286 GLY ALA GLU ASN SER VAL ALA TYR SER ASN ASN SER ILE SEQRES 56 C 1286 ALA ILE PRO ILE ASN PHE THR ILE SER VAL THR THR GLU SEQRES 57 C 1286 ILE LEU PRO VAL SER MET THR LYS THR SER VAL ASP CYS SEQRES 58 C 1286 THR MET TYR ILE CYS GLY ASP SER THR GLU CYS SER ASN SEQRES 59 C 1286 LEU LEU LEU GLN TYR GLY SER PHE CYS THR GLN LEU ASN SEQRES 60 C 1286 ARG ALA LEU THR GLY ILE ALA VAL GLU GLN ASP LYS ASN SEQRES 61 C 1286 THR GLN GLU VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS SEQRES 62 C 1286 THR PRO PRO ILE LYS ASP PHE GLY GLY PHE ASN PHE SER SEQRES 63 C 1286 GLN ILE LEU PRO ASP PRO SER LYS PRO SER LYS ARG SER SEQRES 64 C 1286 PHE ILE GLU ASP LEU LEU PHE ASN LYS VAL THR LEU ALA SEQRES 65 C 1286 ASP ALA GLY PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY SEQRES 66 C 1286 ASP ILE ALA ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE SEQRES 67 C 1286 ASN GLY LEU THR VAL LEU PRO PRO LEU LEU THR ASP GLU SEQRES 68 C 1286 MET ILE ALA GLN TYR THR SER ALA LEU LEU ALA GLY THR SEQRES 69 C 1286 ILE THR SER GLY TRP THR PHE GLY ALA GLY ALA ALA LEU SEQRES 70 C 1286 GLN ILE PRO PHE ALA MET GLN MET ALA TYR ARG PHE ASN SEQRES 71 C 1286 GLY ILE GLY VAL THR GLN ASN VAL LEU TYR GLU ASN GLN SEQRES 72 C 1286 LYS LEU ILE ALA ASN GLN PHE ASN SER ALA ILE GLY LYS SEQRES 73 C 1286 ILE GLN ASP SER LEU SER SER THR ALA SER ALA LEU GLY SEQRES 74 C 1286 LYS LEU GLN ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU SEQRES 75 C 1286 ASN THR LEU VAL LYS GLN LEU SER SER ASN PHE GLY ALA SEQRES 76 C 1286 ILE SER SER VAL LEU ASN ASP ILE LEU ALA ARG LEU ASP SEQRES 77 C 1286 PRO PRO GLU ALA GLU VAL GLN ILE ASP ARG LEU ILE THR SEQRES 78 C 1286 GLY ARG LEU GLN SER LEU GLN THR TYR VAL THR GLN GLN SEQRES 79 C 1286 LEU ILE ARG ALA ALA GLU ILE ARG ALA SER ALA ASN LEU SEQRES 80 C 1286 ALA ALA THR LYS MET SER GLU CYS VAL LEU GLY GLN SER SEQRES 81 C 1286 LYS ARG VAL ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SEQRES 82 C 1286 SER PHE PRO GLN SER ALA PRO HIS GLY VAL VAL PHE LEU SEQRES 83 C 1286 HIS VAL THR TYR VAL PRO ALA GLN GLU LYS ASN PHE THR SEQRES 84 C 1286 THR ALA PRO ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE SEQRES 85 C 1286 PRO ARG GLU GLY VAL PHE VAL SER ASN GLY THR HIS TRP SEQRES 86 C 1286 PHE VAL THR GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE SEQRES 87 C 1286 THR THR HIS ASN THR PHE VAL SER GLY ASN CYS ASP VAL SEQRES 88 C 1286 VAL ILE GLY ILE VAL ASN ASN THR VAL TYR ASP PRO LEU SEQRES 89 C 1286 GLN PRO GLU LEU ASP SER PHE LYS GLU GLU LEU ASP LYS SEQRES 90 C 1286 TYR PHE LYS ASN HIS THR SER PRO ASP VAL ASP LEU GLY SEQRES 91 C 1286 ASP ILE SER GLY ILE ASN ALA SER VAL VAL ASN ILE GLN SEQRES 92 C 1286 LYS GLU ILE ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU SEQRES 93 C 1286 ASN GLU SER LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR SEQRES 94 C 1286 GLU GLN GLU PHE GLY SER GLY GLY TYR ILE PRO GLU ALA SEQRES 95 C 1286 PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU SEQRES 96 C 1286 TRP VAL LEU LEU SER THR PHE LEU LYS GLY GLN ASP ASN SEQRES 97 C 1286 SER ALA ASP ILE GLN HIS SER GLY ARG PRO LEU GLU SER SEQRES 98 C 1286 ARG GLY PRO PHE GLU GLN LYS LEU ILE SER GLU GLU ASP SEQRES 99 C 1286 LEU ASN MET HIS THR GLY HIS HIS HIS HIS HIS HIS SEQRES 1 g 218 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 g 218 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 g 218 SER ASP VAL GLY GLY TYR ASN TYR VAL SER TRP TYR GLN SEQRES 4 g 218 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP SEQRES 5 g 218 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 g 218 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 g 218 GLY LEU GLN SER GLU ASP GLU ALA ASP TYR TYR CYS ASN SEQRES 8 g 218 SER LEU THR SER ILE SER THR TRP VAL PHE GLY GLY GLY SEQRES 9 g 218 THR LYS LEU THR VAL LEU GLY ARG THR VAL ALA ALA PRO SEQRES 10 g 218 SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SEQRES 11 g 218 SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE SEQRES 12 g 218 TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN SEQRES 13 g 218 ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU SEQRES 14 g 218 GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER THR SEQRES 15 g 218 LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL SEQRES 16 g 218 TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO SEQRES 17 g 218 VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 h 223 GLN VAL GLN LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 h 223 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 h 223 PHE THR PHE SER ASN TYR ALA MET TYR TRP VAL ARG GLN SEQRES 4 h 223 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER SEQRES 5 h 223 TYR ASP GLY SER ASN LYS TYR TYR ALA ASP SER VAL LYS SEQRES 6 h 223 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 h 223 LEU TYR LEU GLN MET ASN SER LEU ARG THR GLU ASP THR SEQRES 8 h 223 ALA VAL TYR TYR CYS ALA SER GLY SER ASP TYR GLY ASP SEQRES 9 h 223 TYR LEU LEU VAL TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 h 223 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 h 223 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 h 223 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 h 223 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 h 223 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 h 223 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 h 223 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 h 223 PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SEQRES 18 h 223 SER CYS SEQRES 1 l 218 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 l 218 PRO GLY GLN SER ILE THR ILE SER CYS THR GLY THR SER SEQRES 3 l 218 SER ASP VAL GLY GLY TYR ASN TYR VAL SER TRP TYR GLN SEQRES 4 l 218 GLN HIS PRO GLY LYS ALA PRO LYS LEU MET ILE TYR ASP SEQRES 5 l 218 VAL SER LYS ARG PRO SER GLY VAL SER ASN ARG PHE SER SEQRES 6 l 218 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 l 218 GLY LEU GLN SER GLU ASP GLU ALA ASP TYR TYR CYS ASN SEQRES 8 l 218 SER LEU THR SER ILE SER THR TRP VAL PHE GLY GLY GLY SEQRES 9 l 218 THR LYS LEU THR VAL LEU GLY ARG THR VAL ALA ALA PRO SEQRES 10 l 218 SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SEQRES 11 l 218 SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE SEQRES 12 l 218 TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN SEQRES 13 l 218 ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU SEQRES 14 l 218 GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER THR SEQRES 15 l 218 LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL SEQRES 16 l 218 TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO SEQRES 17 l 218 VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 n 223 GLN VAL GLN LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 n 223 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 n 223 PHE THR PHE SER ASN TYR ALA MET TYR TRP VAL ARG GLN SEQRES 4 n 223 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA VAL ILE SER SEQRES 5 n 223 TYR ASP GLY SER ASN LYS TYR TYR ALA ASP SER VAL LYS SEQRES 6 n 223 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 n 223 LEU TYR LEU GLN MET ASN SER LEU ARG THR GLU ASP THR SEQRES 8 n 223 ALA VAL TYR TYR CYS ALA SER GLY SER ASP TYR GLY ASP SEQRES 9 n 223 TYR LEU LEU VAL TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 n 223 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 n 223 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 n 223 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 n 223 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 n 223 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 n 223 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 n 223 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 n 223 PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SEQRES 18 n 223 SER CYS HET NAG P 1 14 HET NAG P 2 14 HET NAG D 1 14 HET NAG D 2 14 HET NAG E 1 14 HET NAG E 2 14 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG H 1 14 HET NAG H 2 14 HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HET NAG L 1 14 HET NAG L 2 14 HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG X 1 14 HET NAG X 2 14 HET NAG Y 1 14 HET NAG Y 2 14 HET NAG Z 1 14 HET NAG Z 2 14 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET NAG c 1 14 HET NAG c 2 14 HET NAG d 1 14 HET NAG d 2 14 HET NAG e 1 14 HET NAG e 2 14 HET NAG f 1 14 HET NAG f 2 14 HET NAG k 1 14 HET NAG k 2 14 HET NAG m 1 14 HET NAG m 2 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 10 NAG 78(C8 H15 N O6) HELIX 1 AA1 TYR i 51 LYS i 55 5 5 HELIX 2 AA2 PRO i 124 GLY i 132 1 9 HELIX 3 AA3 SER i 186 HIS i 193 1 8 HELIX 4 AA4 GLY i 216 CYS i 218 5 3 HELIX 5 AA5 ARG j 87 THR j 91 5 5 HELIX 6 AA6 SER j 163 LEU j 166 5 4 HELIX 7 AA7 SER j 193 GLY j 197 1 5 HELIX 8 AA8 ASP A 294 LYS A 304 1 11 HELIX 9 AA9 PRO A 337 ALA A 344 1 8 HELIX 10 AB1 SER A 349 TRP A 353 5 5 HELIX 11 AB2 TYR A 365 SER A 371 1 7 HELIX 12 AB3 PRO A 384 LEU A 390 5 7 HELIX 13 AB4 ASP A 405 ILE A 410 5 6 HELIX 14 AB5 GLY A 416 ASN A 422 1 7 HELIX 15 AB6 SER A 438 SER A 443 1 6 HELIX 16 AB7 GLY A 502 TYR A 505 5 4 HELIX 17 AB8 ASN A 616 VAL A 620 5 5 HELIX 18 AB9 ASP A 737 CYS A 743 1 7 HELIX 19 AC1 SER A 746 GLN A 755 1 10 HELIX 20 AC2 SER A 758 ALA A 783 1 26 HELIX 21 AC3 PHE A 817 VAL A 826 1 10 HELIX 22 AC4 THR A 866 GLY A 885 1 20 HELIX 23 AC5 TRP A 886 ALA A 890 5 5 HELIX 24 AC6 PRO A 897 GLY A 910 1 14 HELIX 25 AC7 GLN A 913 THR A 941 1 29 HELIX 26 AC8 LEU A 945 GLN A 965 1 21 HELIX 27 AC9 LEU A 966 SER A 968 5 3 HELIX 28 AD1 VAL A 976 LEU A 984 1 9 HELIX 29 AD2 ASP A 985 VAL A 1033 1 49 HELIX 30 AD3 THR A 1116 HIS A 1118 5 3 HELIX 31 AD4 ASP B 294 LYS B 304 1 11 HELIX 32 AD5 PRO B 337 ASN B 343 1 7 HELIX 33 AD6 ASP B 364 ASN B 370 1 7 HELIX 34 AD7 THR B 385 LEU B 390 5 6 HELIX 35 AD8 GLY B 404 ARG B 408 1 5 HELIX 36 AD9 GLY B 416 ASN B 422 1 7 HELIX 37 AE1 SER B 438 SER B 443 1 6 HELIX 38 AE2 GLN B 498 THR B 500 5 3 HELIX 39 AE3 TYR B 501 GLN B 506 1 6 HELIX 40 AE4 ASN B 616 VAL B 620 5 5 HELIX 41 AE5 ASP B 737 CYS B 743 1 7 HELIX 42 AE6 SER B 746 GLY B 757 1 12 HELIX 43 AE7 SER B 758 ALA B 783 1 26 HELIX 44 AE8 SER B 816 VAL B 826 1 11 HELIX 45 AE9 THR B 866 GLY B 885 1 20 HELIX 46 AF1 TRP B 886 ALA B 890 5 5 HELIX 47 AF2 PRO B 897 GLY B 910 1 14 HELIX 48 AF3 GLN B 913 ASN B 919 1 7 HELIX 49 AF4 ASN B 919 THR B 941 1 23 HELIX 50 AF5 LEU B 945 GLN B 965 1 21 HELIX 51 AF6 LEU B 966 SER B 968 5 3 HELIX 52 AF7 VAL B 976 LEU B 984 1 9 HELIX 53 AF8 ASP B 985 VAL B 1033 1 49 HELIX 54 AF9 ASP C 294 LYS C 304 1 11 HELIX 55 AG1 PHE C 338 ALA C 344 1 7 HELIX 56 AG2 SER C 349 TRP C 353 5 5 HELIX 57 AG3 TYR C 365 SER C 371 1 7 HELIX 58 AG4 SER C 383 LEU C 390 1 8 HELIX 59 AG5 GLY C 404 ARG C 408 1 5 HELIX 60 AG6 GLY C 416 ASN C 422 1 7 HELIX 61 AG7 SER C 438 SER C 443 1 6 HELIX 62 AG8 ASN C 616 VAL C 620 5 5 HELIX 63 AG9 ASP C 737 GLY C 744 1 8 HELIX 64 AH1 SER C 746 GLY C 757 1 12 HELIX 65 AH2 SER C 758 ALA C 783 1 26 HELIX 66 AH3 SER C 816 VAL C 826 1 11 HELIX 67 AH4 THR C 866 SER C 884 1 19 HELIX 68 AH5 TRP C 886 GLY C 891 1 6 HELIX 69 AH6 PRO C 897 GLY C 910 1 14 HELIX 70 AH7 THR C 912 ASN C 919 1 8 HELIX 71 AH8 ASN C 919 THR C 941 1 23 HELIX 72 AH9 LEU C 945 LEU C 966 1 22 HELIX 73 AI1 VAL C 976 LEU C 984 1 9 HELIX 74 AI2 ASP C 985 VAL C 1033 1 49 HELIX 75 AI3 GLN C 1142 ASP C 1146 5 5 HELIX 76 AI4 GLN g 81 GLU g 85 5 5 HELIX 77 AI5 SER g 125 GLY g 132 1 8 HELIX 78 AI6 LYS g 187 HIS g 193 1 7 HELIX 79 AI7 THR h 28 TYR h 32 5 5 HELIX 80 AI8 SER h 163 ALA h 165 5 3 HELIX 81 AI9 LYS h 208 ASN h 211 5 4 HELIX 82 AJ1 THR l 25 TYR l 32 1 8 HELIX 83 AJ2 GLN l 81 GLU l 85 5 5 HELIX 84 AJ3 SER l 125 GLY l 132 1 8 HELIX 85 AJ4 LYS l 187 HIS l 193 1 7 HELIX 86 AJ5 GLY l 216 CYS l 218 5 3 HELIX 87 AJ6 ARG n 87 THR n 91 5 5 HELIX 88 AJ7 SER n 163 THR n 167 5 5 HELIX 89 AJ8 SER n 194 LEU n 196 5 3 SHEET 1 AA1 2 SER i 9 GLY i 12 0 SHEET 2 AA1 2 LYS i 106 VAL i 109 1 O THR i 108 N VAL i 10 SHEET 1 AA2 3 SER i 17 THR i 23 0 SHEET 2 AA2 3 THR i 72 SER i 78 -1 O LEU i 75 N ILE i 20 SHEET 3 AA2 3 PHE i 64 SER i 69 -1 N SER i 69 O THR i 72 SHEET 1 AA3 4 LYS i 47 ILE i 50 0 SHEET 2 AA3 4 SER i 36 GLN i 40 -1 N GLN i 39 O LYS i 47 SHEET 3 AA3 4 ASP i 87 THR i 94 -1 O TYR i 89 N TYR i 38 SHEET 4 AA3 4 THR i 98 PHE i 101 -1 O VAL i 100 N SER i 92 SHEET 1 AA4 4 SER i 118 PHE i 122 0 SHEET 2 AA4 4 ALA i 134 PHE i 143 -1 O LEU i 139 N PHE i 120 SHEET 3 AA4 4 TYR i 177 LEU i 185 -1 O TYR i 177 N PHE i 143 SHEET 4 AA4 4 SER i 163 VAL i 167 -1 N SER i 166 O SER i 180 SHEET 1 AA5 4 ALA i 157 GLN i 159 0 SHEET 2 AA5 4 LYS i 149 VAL i 154 -1 N VAL i 154 O ALA i 157 SHEET 3 AA5 4 VAL i 195 THR i 201 -1 O GLU i 199 N GLN i 151 SHEET 4 AA5 4 VAL i 209 ASN i 214 -1 O PHE i 213 N TYR i 196 SHEET 1 AA6 4 GLN j 3 SER j 7 0 SHEET 2 AA6 4 LEU j 18 SER j 25 -1 O SER j 21 N SER j 7 SHEET 3 AA6 4 THR j 78 MET j 83 -1 O LEU j 79 N CYS j 22 SHEET 4 AA6 4 THR j 69 ASP j 73 -1 N THR j 69 O GLN j 82 SHEET 1 AA7 2 VAL j 11 VAL j 12 0 SHEET 2 AA7 2 THR j 117 VAL j 118 1 O THR j 117 N VAL j 12 SHEET 1 AA8 5 LYS j 58 TYR j 60 0 SHEET 2 AA8 5 LEU j 45 SER j 52 -1 N VAL j 50 O TYR j 59 SHEET 3 AA8 5 ALA j 33 GLN j 39 -1 N TRP j 36 O ALA j 49 SHEET 4 AA8 5 VAL j 93 SER j 98 -1 O TYR j 95 N VAL j 37 SHEET 5 AA8 5 TYR j 109 TRP j 110 -1 O TYR j 109 N SER j 98 SHEET 1 AA9 5 LYS j 58 TYR j 60 0 SHEET 2 AA9 5 LEU j 45 SER j 52 -1 N VAL j 50 O TYR j 59 SHEET 3 AA9 5 ALA j 33 GLN j 39 -1 N TRP j 36 O ALA j 49 SHEET 4 AA9 5 VAL j 93 SER j 98 -1 O TYR j 95 N VAL j 37 SHEET 5 AA9 5 THR j 114 LEU j 115 -1 O THR j 114 N TYR j 94 SHEET 1 AB1 4 SER j 127 PRO j 130 0 SHEET 2 AB1 4 THR j 142 LYS j 150 -1 O LEU j 148 N PHE j 129 SHEET 3 AB1 4 SER j 186 PRO j 192 -1 O VAL j 191 N ALA j 143 SHEET 4 AB1 4 VAL j 170 THR j 172 -1 N HIS j 171 O VAL j 188 SHEET 1 AB2 3 THR j 158 TRP j 161 0 SHEET 2 AB2 3 TYR j 201 HIS j 207 -1 O ASN j 206 N THR j 158 SHEET 3 AB2 3 SER j 210 VAL j 218 -1 O VAL j 214 N VAL j 205 SHEET 1 AB3 2 VAL j 176 LEU j 177 0 SHEET 2 AB3 2 TYR j 183 SER j 184 -1 O SER j 184 N VAL j 176 SHEET 1 AB4 8 THR A 32 SER A 34 0 SHEET 2 AB4 8 SER A 63 PHE A 68 -1 O VAL A 65 N THR A 32 SHEET 3 AB4 8 TYR A 265 TYR A 269 -1 O TYR A 265 N PHE A 68 SHEET 4 AB4 8 GLY A 90 THR A 96 -1 N TYR A 92 O GLY A 268 SHEET 5 AB4 8 ASN A 188 ILE A 197 -1 O PHE A 192 N PHE A 93 SHEET 6 AB4 8 TYR A 200 PRO A 209 -1 O TYR A 200 N ILE A 197 SHEET 7 AB4 8 ALA A 222 PRO A 225 -1 O GLU A 224 N SER A 205 SHEET 8 AB4 8 VAL A 39 TYR A 40 1 N VAL A 39 O LEU A 223 SHEET 1 AB5 2 VAL A 45 PHE A 46 0 SHEET 2 AB5 2 PHE C 565 GLY C 566 1 O PHE C 565 N PHE A 46 SHEET 1 AB6 3 LEU A 51 PHE A 58 0 SHEET 2 AB6 3 GLN A 271 TYR A 279 -1 O LEU A 277 N HIS A 52 SHEET 3 AB6 3 ILE A 285 ASP A 290 -1 O VAL A 289 N LEU A 276 SHEET 1 AB7 6 LEU A 85 PRO A 86 0 SHEET 2 AB7 6 ARG A 237 LEU A 241 -1 O PHE A 238 N LEU A 85 SHEET 3 AB7 6 GLY A 104 GLY A 108 -1 N ILE A 106 O GLN A 239 SHEET 4 AB7 6 SER A 117 ASN A 122 -1 O ILE A 120 N TRP A 105 SHEET 5 AB7 6 VAL A 127 VAL A 131 -1 O VAL A 128 N VAL A 121 SHEET 6 AB7 6 PHE A 168 SER A 172 -1 O SER A 172 N VAL A 127 SHEET 1 AB8 5 GLY A 311 GLN A 314 0 SHEET 2 AB8 5 VAL A 595 THR A 599 -1 O VAL A 597 N TYR A 313 SHEET 3 AB8 5 ALA A 609 GLN A 613 -1 O ALA A 609 N ILE A 598 SHEET 4 AB8 5 GLY A 648 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 5 AB8 5 VAL A 642 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AB9 2 PHE A 318 ARG A 319 0 SHEET 2 AB9 2 PHE A 592 GLY A 593 -1 O GLY A 593 N PHE A 318 SHEET 1 AC1 5 GLU A 324 VAL A 327 0 SHEET 2 AC1 5 CYS A 538 ASN A 542 1 O ASN A 540 N ILE A 326 SHEET 3 AC1 5 THR A 547 GLU A 554 -1 O GLY A 548 N PHE A 541 SHEET 4 AC1 5 ILE A 584 THR A 588 -1 O ASP A 586 N THR A 553 SHEET 5 AC1 5 ALA A 575 ARG A 577 -1 N VAL A 576 O LEU A 585 SHEET 1 AC2 5 ASN A 354 ILE A 358 0 SHEET 2 AC2 5 VAL A 395 ARG A 403 -1 O ALA A 397 N LYS A 356 SHEET 3 AC2 5 PRO A 507 PHE A 515 -1 O VAL A 512 N ASP A 398 SHEET 4 AC2 5 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 5 AC2 5 THR A 376 CYS A 379 -1 N LYS A 378 O VAL A 433 SHEET 1 AC3 2 CYS A 361 VAL A 362 0 SHEET 2 AC3 2 VAL A 524 CYS A 525 1 O CYS A 525 N CYS A 361 SHEET 1 AC4 2 LEU A 452 ARG A 454 0 SHEET 2 AC4 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AC5 2 TYR A 473 GLN A 474 0 SHEET 2 AC5 2 CYS A 488 TYR A 489 -1 O TYR A 489 N TYR A 473 SHEET 1 AC6 2 PHE A 565 GLY A 566 0 SHEET 2 AC6 2 VAL B 45 PHE B 46 1 O PHE B 46 N PHE A 565 SHEET 1 AC7 4 GLU A 654 HIS A 655 0 SHEET 2 AC7 4 SER A 691 THR A 696 1 O ILE A 692 N GLU A 654 SHEET 3 AC7 4 ILE A 670 GLN A 675 -1 N SER A 673 O ILE A 693 SHEET 4 AC7 4 ILE A 664 GLY A 667 -1 N ILE A 664 O ALA A 672 SHEET 1 AC8 2 ALA A 701 ASN A 703 0 SHEET 2 AC8 2 GLN B 787 TYR B 789 1 O ILE B 788 N ASN A 703 SHEET 1 AC9 2 SER A 711 PRO A 715 0 SHEET 2 AC9 2 GLU A1072 THR A1076 -1 O LYS A1073 N ILE A 714 SHEET 1 AD1 3 PHE A 718 PRO A 728 0 SHEET 2 AD1 3 GLY A1059 PRO A1069 -1 O VAL A1068 N THR A 719 SHEET 3 AD1 3 TYR A1047 ALA A1056 -1 N TYR A1047 O TYR A1067 SHEET 1 AD2 2 LYS A 733 VAL A 736 0 SHEET 2 AD2 2 LEU A 858 LEU A 861 -1 O LEU A 861 N LYS A 733 SHEET 1 AD3 4 THR A1120 ASN A1125 0 SHEET 2 AD3 4 LYS A1086 PRO A1090 -1 N ALA A1087 O GLY A1124 SHEET 3 AD3 4 ILE A1081 CYS A1082 -1 N ILE A1081 O HIS A1088 SHEET 4 AD3 4 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SHEET 1 AD4 2 VAL A1094 SER A1097 0 SHEET 2 AD4 2 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 1 AD5 7 TYR B 31 SER B 34 0 SHEET 2 AD5 7 SER B 63 PHE B 68 -1 O VAL B 65 N THR B 32 SHEET 3 AD5 7 TYR B 265 TYR B 269 -1 O TYR B 265 N PHE B 68 SHEET 4 AD5 7 GLY B 90 THR B 96 -1 N TYR B 92 O GLY B 268 SHEET 5 AD5 7 ASN B 188 ILE B 197 -1 O PHE B 192 N PHE B 93 SHEET 6 AD5 7 TYR B 200 PRO B 209 -1 O TYR B 200 N ILE B 197 SHEET 7 AD5 7 GLU B 224 PRO B 225 -1 O GLU B 224 N SER B 205 SHEET 1 AD6 7 TYR B 31 SER B 34 0 SHEET 2 AD6 7 SER B 63 PHE B 68 -1 O VAL B 65 N THR B 32 SHEET 3 AD6 7 TYR B 265 TYR B 269 -1 O TYR B 265 N PHE B 68 SHEET 4 AD6 7 GLY B 90 THR B 96 -1 N TYR B 92 O GLY B 268 SHEET 5 AD6 7 ASN B 188 ILE B 197 -1 O PHE B 192 N PHE B 93 SHEET 6 AD6 7 TYR B 200 PRO B 209 -1 O TYR B 200 N ILE B 197 SHEET 7 AD6 7 LEU B 229 PRO B 230 -1 O LEU B 229 N PHE B 201 SHEET 1 AD7 3 LEU B 51 PHE B 58 0 SHEET 2 AD7 3 GLN B 271 TYR B 279 -1 O LEU B 277 N HIS B 52 SHEET 3 AD7 3 ILE B 285 ASP B 290 -1 O VAL B 289 N LEU B 276 SHEET 1 AD8 6 LEU B 85 PRO B 86 0 SHEET 2 AD8 6 ARG B 237 THR B 240 -1 O PHE B 238 N LEU B 85 SHEET 3 AD8 6 GLY B 104 GLY B 108 -1 N ILE B 106 O GLN B 239 SHEET 4 AD8 6 LEU B 119 ASN B 122 -1 O ILE B 120 N TRP B 105 SHEET 5 AD8 6 VAL B 127 LYS B 130 -1 O LYS B 130 N LEU B 119 SHEET 6 AD8 6 GLU B 169 SER B 172 -1 O TYR B 170 N ILE B 129 SHEET 1 AD9 2 PHE B 134 PHE B 136 0 SHEET 2 AD9 2 TYR B 160 ALA B 163 -1 O SER B 162 N GLN B 135 SHEET 1 AE1 5 GLU B 309 ARG B 319 0 SHEET 2 AE1 5 PHE B 592 GLY B 601 -1 O VAL B 597 N TYR B 313 SHEET 3 AE1 5 ALA B 609 GLN B 613 -1 O GLN B 613 N GLY B 594 SHEET 4 AE1 5 GLY B 648 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AE1 5 VAL B 642 GLN B 644 -1 N PHE B 643 O LEU B 650 SHEET 1 AE2 5 SER B 325 ARG B 328 0 SHEET 2 AE2 5 VAL B 539 PHE B 543 1 O ASN B 542 N ARG B 328 SHEET 3 AE2 5 LEU B 546 GLU B 554 -1 O LEU B 546 N PHE B 543 SHEET 4 AE2 5 ILE B 584 PRO B 589 -1 O THR B 588 N VAL B 551 SHEET 5 AE2 5 ALA B 575 ARG B 577 -1 N VAL B 576 O LEU B 585 SHEET 1 AE3 4 ASN B 354 ILE B 358 0 SHEET 2 AE3 4 VAL B 395 ARG B 403 -1 O VAL B 395 N ILE B 358 SHEET 3 AE3 4 PRO B 507 PHE B 515 -1 O TYR B 508 N ILE B 402 SHEET 4 AE3 4 VAL B 433 ASN B 437 -1 N ILE B 434 O VAL B 511 SHEET 1 AE4 2 LEU B 452 ARG B 454 0 SHEET 2 AE4 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AE5 2 PHE B 565 GLY B 566 0 SHEET 2 AE5 2 VAL C 45 PHE C 46 1 O PHE C 46 N PHE B 565 SHEET 1 AE6 4 GLU B 654 TYR B 660 0 SHEET 2 AE6 4 ILE B 693 MET B 697 1 O ALA B 694 N VAL B 656 SHEET 3 AE6 4 ILE B 670 SER B 673 -1 N SER B 673 O ILE B 693 SHEET 4 AE6 4 ILE B 664 ILE B 666 -1 N ILE B 666 O ILE B 670 SHEET 1 AE7 2 GLU B 702 SER B 704 0 SHEET 2 AE7 2 ILE C 788 LYS C 790 1 O ILE C 788 N ASN B 703 SHEET 1 AE8 3 ILE B 714 PRO B 728 0 SHEET 2 AE8 3 GLY B1059 LYS B1073 -1 O VAL B1068 N THR B 719 SHEET 3 AE8 3 TYR B1047 ALA B1056 -1 N GLN B1054 O VAL B1061 SHEET 1 AE9 2 LYS B 733 VAL B 736 0 SHEET 2 AE9 2 LEU B 858 LEU B 861 -1 O LEU B 861 N LYS B 733 SHEET 1 AF1 4 THR B1076 THR B1077 0 SHEET 2 AF1 4 VAL B1094 SER B1097 -1 O SER B1097 N THR B1076 SHEET 3 AF1 4 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 4 AF1 4 GLN B1113 ILE B1114 -1 O GLN B1113 N VAL B1104 SHEET 1 AF2 4 THR B1120 VAL B1122 0 SHEET 2 AF2 4 ALA B1087 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AF2 4 ILE B1081 CYS B1082 -1 N ILE B1081 O HIS B1088 SHEET 4 AF2 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AF3 7 TYR C 31 SER C 34 0 SHEET 2 AF3 7 SER C 63 PHE C 68 -1 O SER C 63 N SER C 34 SHEET 3 AF3 7 TYR C 265 TYR C 269 -1 O VAL C 267 N THR C 66 SHEET 4 AF3 7 VAL C 91 GLU C 97 -1 N TYR C 92 O GLY C 268 SHEET 5 AF3 7 ASN C 188 ILE C 197 -1 O PHE C 192 N PHE C 93 SHEET 6 AF3 7 TYR C 200 SER C 205 -1 O LYS C 202 N LYS C 195 SHEET 7 AF3 7 GLU C 224 PRO C 230 -1 O LEU C 229 N PHE C 201 SHEET 1 AF4 3 LEU C 51 PHE C 58 0 SHEET 2 AF4 3 GLN C 271 TYR C 279 -1 O PHE C 275 N THR C 54 SHEET 3 AF4 3 ILE C 285 ASP C 290 -1 O VAL C 289 N LEU C 276 SHEET 1 AF5 6 LEU C 85 PRO C 86 0 SHEET 2 AF5 6 ARG C 237 LEU C 241 -1 O PHE C 238 N LEU C 85 SHEET 3 AF5 6 GLY C 104 GLY C 108 -1 N ILE C 106 O GLN C 239 SHEET 4 AF5 6 SER C 117 ASN C 123 -1 O LEU C 118 N PHE C 107 SHEET 5 AF5 6 ASN C 126 CYS C 132 -1 O ASN C 126 N ASN C 123 SHEET 6 AF5 6 CYS C 166 SER C 172 -1 O TYR C 170 N ILE C 129 SHEET 1 AF6 5 GLY C 311 ARG C 319 0 SHEET 2 AF6 5 PHE C 592 THR C 599 -1 O VAL C 597 N TYR C 313 SHEET 3 AF6 5 ALA C 609 GLN C 613 -1 O ALA C 609 N ILE C 598 SHEET 4 AF6 5 GLY C 648 ILE C 651 -1 O CYS C 649 N TYR C 612 SHEET 5 AF6 5 VAL C 642 THR C 645 -1 N PHE C 643 O LEU C 650 SHEET 1 AF7 5 SER C 325 VAL C 327 0 SHEET 2 AF7 5 CYS C 538 ASN C 542 1 O ASN C 542 N ILE C 326 SHEET 3 AF7 5 THR C 547 GLU C 554 -1 O GLY C 548 N PHE C 541 SHEET 4 AF7 5 ILE C 584 THR C 588 -1 O ASP C 586 N THR C 553 SHEET 5 AF7 5 ALA C 575 ARG C 577 -1 N VAL C 576 O LEU C 585 SHEET 1 AF8 5 ASN C 354 ILE C 358 0 SHEET 2 AF8 5 VAL C 395 ARG C 403 -1 O ALA C 397 N LYS C 356 SHEET 3 AF8 5 PRO C 507 PHE C 515 -1 O VAL C 512 N ASP C 398 SHEET 4 AF8 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AF8 5 THR C 376 CYS C 379 -1 N LYS C 378 O VAL C 433 SHEET 1 AF9 3 CYS C 361 VAL C 362 0 SHEET 2 AF9 3 VAL C 524 CYS C 525 1 O CYS C 525 N CYS C 361 SHEET 3 AF9 3 CYS C 391 PHE C 392 -1 N PHE C 392 O VAL C 524 SHEET 1 AG1 2 LEU C 452 ARG C 454 0 SHEET 2 AG1 2 LEU C 492 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AG2 2 TYR C 473 GLN C 474 0 SHEET 2 AG2 2 CYS C 488 TYR C 489 -1 O TYR C 489 N TYR C 473 SHEET 1 AG3 4 GLU C 654 HIS C 655 0 SHEET 2 AG3 4 ILE C 693 THR C 696 1 O ALA C 694 N GLU C 654 SHEET 3 AG3 4 ILE C 670 SER C 673 -1 N SER C 673 O ILE C 693 SHEET 4 AG3 4 ILE C 664 GLY C 667 -1 N ILE C 666 O ILE C 670 SHEET 1 AG4 3 SER C 711 PRO C 728 0 SHEET 2 AG4 3 GLY C1059 THR C1076 -1 O VAL C1068 N THR C 719 SHEET 3 AG4 3 TYR C1047 ALA C1056 -1 N GLN C1054 O VAL C1061 SHEET 1 AG5 2 LYS C 733 VAL C 736 0 SHEET 2 AG5 2 LEU C 858 LEU C 861 -1 O LEU C 861 N LYS C 733 SHEET 1 AG6 4 THR C1120 VAL C1122 0 SHEET 2 AG6 4 LYS C1086 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AG6 4 ILE C1081 HIS C1083 -1 N ILE C1081 O HIS C1088 SHEET 4 AG6 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AG7 3 VAL C1094 SER C1097 0 SHEET 2 AG7 3 TRP C1102 THR C1105 -1 O THR C1105 N VAL C1094 SHEET 3 AG7 3 GLN C1113 ILE C1114 -1 O GLN C1113 N VAL C1104 SHEET 1 AG8 5 SER g 9 GLY g 12 0 SHEET 2 AG8 5 THR g 105 VAL g 109 1 O LYS g 106 N VAL g 10 SHEET 3 AG8 5 ALA g 86 LEU g 93 -1 N TYR g 88 O THR g 105 SHEET 4 AG8 5 SER g 36 GLN g 40 -1 N SER g 36 O ASN g 91 SHEET 5 AG8 5 LYS g 47 LEU g 48 -1 O LYS g 47 N GLN g 39 SHEET 1 AG9 4 SER g 9 GLY g 12 0 SHEET 2 AG9 4 THR g 105 VAL g 109 1 O LYS g 106 N VAL g 10 SHEET 3 AG9 4 ALA g 86 LEU g 93 -1 N TYR g 88 O THR g 105 SHEET 4 AG9 4 TRP g 99 PHE g 101 -1 O VAL g 100 N SER g 92 SHEET 1 AH1 3 ILE g 18 THR g 23 0 SHEET 2 AH1 3 THR g 72 ILE g 77 -1 O ALA g 73 N CYS g 22 SHEET 3 AH1 3 PHE g 64 SER g 69 -1 N SER g 65 O THR g 76 SHEET 1 AH2 4 SER g 118 PHE g 122 0 SHEET 2 AH2 4 THR g 133 PHE g 143 -1 O LEU g 139 N PHE g 120 SHEET 3 AH2 4 TYR g 177 SER g 186 -1 O LEU g 183 N VAL g 136 SHEET 4 AH2 4 SER g 163 VAL g 167 -1 N SER g 166 O SER g 180 SHEET 1 AH3 4 ALA g 157 GLN g 159 0 SHEET 2 AH3 4 LYS g 149 VAL g 154 -1 N TRP g 152 O GLN g 159 SHEET 3 AH3 4 VAL g 195 THR g 201 -1 O ALA g 197 N LYS g 153 SHEET 4 AH3 4 VAL g 209 ASN g 214 -1 O VAL g 209 N VAL g 200 SHEET 1 AH4 4 GLN h 3 SER h 7 0 SHEET 2 AH4 4 LEU h 18 SER h 25 -1 O SER h 21 N SER h 7 SHEET 3 AH4 4 THR h 78 MET h 83 -1 O LEU h 79 N CYS h 22 SHEET 4 AH4 4 PHE h 68 ASP h 73 -1 N THR h 69 O GLN h 82 SHEET 1 AH5 6 VAL h 11 VAL h 12 0 SHEET 2 AH5 6 THR h 114 VAL h 118 1 O THR h 117 N VAL h 12 SHEET 3 AH5 6 ALA h 92 SER h 98 -1 N TYR h 94 O THR h 114 SHEET 4 AH5 6 MET h 34 GLN h 39 -1 N VAL h 37 O TYR h 95 SHEET 5 AH5 6 LEU h 45 ILE h 51 -1 O GLU h 46 N ARG h 38 SHEET 6 AH5 6 LYS h 58 TYR h 59 -1 O TYR h 59 N VAL h 50 SHEET 1 AH6 4 VAL h 11 VAL h 12 0 SHEET 2 AH6 4 THR h 114 VAL h 118 1 O THR h 117 N VAL h 12 SHEET 3 AH6 4 ALA h 92 SER h 98 -1 N TYR h 94 O THR h 114 SHEET 4 AH6 4 TYR h 109 TRP h 110 -1 N TYR h 109 O SER h 98 SHEET 1 AH7 4 VAL h 128 LEU h 131 0 SHEET 2 AH7 4 THR h 142 VAL h 149 -1 O GLY h 146 N LEU h 131 SHEET 3 AH7 4 SER h 186 PRO h 192 -1 O VAL h 191 N ALA h 143 SHEET 4 AH7 4 VAL h 170 THR h 172 -1 N HIS h 171 O VAL h 188 SHEET 1 AH8 3 THR h 158 TRP h 161 0 SHEET 2 AH8 3 TYR h 201 HIS h 207 -1 O ASN h 204 N SER h 160 SHEET 3 AH8 3 THR h 212 VAL h 218 -1 O LYS h 216 N CYS h 203 SHEET 1 AH9 2 VAL h 176 LEU h 177 0 SHEET 2 AH9 2 TYR h 183 SER h 184 -1 O SER h 184 N VAL h 176 SHEET 1 AI1 5 SER l 9 GLY l 12 0 SHEET 2 AI1 5 THR l 105 VAL l 109 1 O LYS l 106 N VAL l 10 SHEET 3 AI1 5 ASP l 87 LEU l 93 -1 N TYR l 88 O THR l 105 SHEET 4 AI1 5 SER l 36 GLN l 40 -1 N TYR l 38 O TYR l 89 SHEET 5 AI1 5 LYS l 47 LEU l 48 -1 O LYS l 47 N GLN l 39 SHEET 1 AI2 4 SER l 9 GLY l 12 0 SHEET 2 AI2 4 THR l 105 VAL l 109 1 O LYS l 106 N VAL l 10 SHEET 3 AI2 4 ASP l 87 LEU l 93 -1 N TYR l 88 O THR l 105 SHEET 4 AI2 4 TRP l 99 PHE l 101 -1 O VAL l 100 N SER l 92 SHEET 1 AI3 3 SER l 17 THR l 23 0 SHEET 2 AI3 3 THR l 72 SER l 78 -1 O LEU l 75 N ILE l 20 SHEET 3 AI3 3 PHE l 64 SER l 69 -1 N SER l 69 O THR l 72 SHEET 1 AI4 4 SER l 118 PHE l 122 0 SHEET 2 AI4 4 THR l 133 PHE l 143 -1 O LEU l 139 N PHE l 120 SHEET 3 AI4 4 TYR l 177 SER l 186 -1 O LEU l 179 N LEU l 140 SHEET 4 AI4 4 SER l 163 VAL l 167 -1 N SER l 166 O SER l 180 SHEET 1 AI5 4 ALA l 157 LEU l 158 0 SHEET 2 AI5 4 LYS l 149 VAL l 154 -1 N VAL l 154 O ALA l 157 SHEET 3 AI5 4 VAL l 195 THR l 201 -1 O GLU l 199 N GLN l 151 SHEET 4 AI5 4 VAL l 209 ASN l 214 -1 O LYS l 211 N CYS l 198 SHEET 1 AI6 4 GLN n 3 SER n 7 0 SHEET 2 AI6 4 LEU n 18 SER n 25 -1 O SER n 25 N GLN n 3 SHEET 3 AI6 4 THR n 78 MET n 83 -1 O MET n 83 N LEU n 18 SHEET 4 AI6 4 PHE n 68 ASP n 73 -1 N THR n 69 O GLN n 82 SHEET 1 AI7 6 VAL n 11 VAL n 12 0 SHEET 2 AI7 6 THR n 114 VAL n 118 1 O THR n 117 N VAL n 12 SHEET 3 AI7 6 ALA n 92 SER n 98 -1 N TYR n 94 O THR n 114 SHEET 4 AI7 6 MET n 34 GLN n 39 -1 N TYR n 35 O ALA n 97 SHEET 5 AI7 6 LEU n 45 ILE n 51 -1 O GLU n 46 N ARG n 38 SHEET 6 AI7 6 LYS n 58 TYR n 59 -1 O TYR n 59 N VAL n 50 SHEET 1 AI8 4 VAL n 11 VAL n 12 0 SHEET 2 AI8 4 THR n 114 VAL n 118 1 O THR n 117 N VAL n 12 SHEET 3 AI8 4 ALA n 92 SER n 98 -1 N TYR n 94 O THR n 114 SHEET 4 AI8 4 TYR n 109 TRP n 110 -1 N TYR n 109 O SER n 98 SHEET 1 AI9 4 VAL n 128 LEU n 131 0 SHEET 2 AI9 4 THR n 142 VAL n 149 -1 O LEU n 148 N PHE n 129 SHEET 3 AI9 4 TYR n 183 PRO n 192 -1 O VAL n 191 N ALA n 143 SHEET 4 AI9 4 VAL n 170 THR n 172 -1 N HIS n 171 O VAL n 188 SHEET 1 AJ1 4 VAL n 128 LEU n 131 0 SHEET 2 AJ1 4 THR n 142 VAL n 149 -1 O LEU n 148 N PHE n 129 SHEET 3 AJ1 4 TYR n 183 PRO n 192 -1 O VAL n 191 N ALA n 143 SHEET 4 AJ1 4 VAL n 176 LEU n 177 -1 N VAL n 176 O SER n 184 SHEET 1 AJ2 3 THR n 158 TRP n 161 0 SHEET 2 AJ2 3 TYR n 201 HIS n 207 -1 O ASN n 206 N THR n 158 SHEET 3 AJ2 3 THR n 212 VAL n 218 -1 O LYS n 216 N CYS n 203 SSBOND 1 CYS i 22 CYS i 90 1555 1555 2.04 SSBOND 2 CYS i 138 CYS i 198 1555 1555 2.04 SSBOND 3 CYS i 218 CYS j 223 1555 1555 2.03 SSBOND 4 CYS j 22 CYS j 96 1555 1555 2.04 SSBOND 5 CYS j 147 CYS j 203 1555 1555 2.03 SSBOND 6 CYS A 132 CYS A 166 1555 1555 2.03 SSBOND 7 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 8 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 9 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 10 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 11 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 12 CYS A 617 CYS A 649 1555 1555 2.04 SSBOND 13 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 14 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 15 CYS A 743 CYS A 749 1555 1555 2.02 SSBOND 16 CYS A 1032 CYS A 1043 1555 1555 2.02 SSBOND 17 CYS A 1082 CYS A 1126 1555 1555 2.04 SSBOND 18 CYS B 132 CYS B 166 1555 1555 2.03 SSBOND 19 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 20 CYS B 336 CYS B 361 1555 1555 2.04 SSBOND 21 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 22 CYS B 391 CYS B 525 1555 1555 2.03 SSBOND 23 CYS B 480 CYS B 488 1555 1555 2.04 SSBOND 24 CYS B 538 CYS B 590 1555 1555 2.03 SSBOND 25 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 26 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 27 CYS B 738 CYS B 760 1555 1555 2.03 SSBOND 28 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 29 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 30 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 31 CYS C 132 CYS C 166 1555 1555 2.03 SSBOND 32 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 33 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 34 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 35 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 36 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 37 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 38 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 39 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 40 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 41 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 42 CYS C 1032 CYS C 1043 1555 1555 2.02 SSBOND 43 CYS C 1082 CYS C 1126 1555 1555 2.04 SSBOND 44 CYS g 22 CYS g 90 1555 1555 2.03 SSBOND 45 CYS g 138 CYS g 198 1555 1555 2.03 SSBOND 46 CYS g 218 CYS h 223 1555 1555 2.03 SSBOND 47 CYS h 22 CYS h 96 1555 1555 2.03 SSBOND 48 CYS h 147 CYS h 203 1555 1555 2.03 SSBOND 49 CYS l 22 CYS l 90 1555 1555 2.03 SSBOND 50 CYS l 138 CYS l 198 1555 1555 2.03 SSBOND 51 CYS l 218 CYS n 223 1555 1555 2.03 SSBOND 52 CYS n 22 CYS n 96 1555 1555 2.03 SSBOND 53 CYS n 147 CYS n 203 1555 1555 2.03 LINK ND2 ASN A 64 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 123 C1 NAG D 1 1555 1555 1.45 LINK ND2 ASN A 165 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 282 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG F 1 1555 1555 1.43 LINK ND2 ASN A 603 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN A 709 C1 NAG H 1 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG I 1 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG J 1 1555 1555 1.44 LINK ND2 ASN A1074 C1 NAG K 1 1555 1555 1.43 LINK ND2 ASN A1098 C1 NAG L 1 1555 1555 1.44 LINK ND2 ASN A1134 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN B 64 C1 NAG B1301 1555 1555 1.43 LINK ND2 ASN B 123 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN B 165 C1 NAG B1302 1555 1555 1.45 LINK ND2 ASN B 234 C1 NAG B1303 1555 1555 1.43 LINK ND2 ASN B 282 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN B 331 C1 NAG B1304 1555 1555 1.47 LINK ND2 ASN B 343 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN B 603 C1 NAG B1305 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG Q 1 1555 1555 1.43 LINK ND2 ASN B 657 C1 NAG B1306 1555 1555 1.44 LINK ND2 ASN B 709 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN B 717 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN B1074 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN B1098 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN C 64 C1 NAG C1301 1555 1555 1.43 LINK ND2 ASN C 123 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C 165 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 234 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN C 282 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN C 343 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN C 603 C1 NAG C1304 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN C 657 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C 709 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN C 717 C1 NAG d 1 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG e 1 1555 1555 1.44 LINK ND2 ASN C1074 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG m 1 1555 1555 1.44 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.44 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.44 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.45 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.45 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.44 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.47 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.44 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.44 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.44 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.44 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.44 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.45 CISPEP 1 TYR g 144 PRO g 145 0 0.40 CISPEP 2 PHE h 153 PRO h 154 0 -6.75 CISPEP 3 GLU h 155 PRO h 156 0 -4.48 CISPEP 4 TYR l 144 PRO l 145 0 1.25 CISPEP 5 PHE n 153 PRO n 154 0 -2.98 CISPEP 6 GLU n 155 PRO n 156 0 1.34 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000