HEADER VIRAL PROTEIN 12-DEC-24 9MI3 TITLE CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE PROTEIN IN COMPLEX WITH TITLE 2 NEUTRALIZING HUMAN ANTIBODY WRAIR-2008 COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, C, K; COMPND 4 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: WRAIR-2008 ANTIBODY FAB HEAVY CHAIN; COMPND 8 CHAIN: B, E, H; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: WRAIR-2008 ANTIBODY FAB LIGHT CHAIN; COMPND 12 CHAIN: D, F, L; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_TAXID: 2697049; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_TAXID: 9606; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_COMMON: HUMAN; SOURCE 16 ORGANISM_TAXID: 9606; SOURCE 17 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 18 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS VIRAL PROTEIN, IMMUNE SYSTEM, SEVERE ACUTE RESPIRATORY SYNDROME KEYWDS 2 CORONAVIRUS 2, HEXAPRO, NEUTRALIZING ANTIBODY, HUMAN ANTIBODY EXPDTA ELECTRON MICROSCOPY AUTHOR J.L.JENSEN,P.V.THOMAS,M.G.JOYCE REVDAT 1 20-AUG-25 9MI3 0 JRNL AUTH J.L.JENSEN,P.V.THOMAS,M.G.JOYCE JRNL TITL CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE PROTEIN IN COMPLEX JRNL TITL 2 WITH NEUTRALIZING HUMAN ANTIBODY WRAIR-2008 JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.23 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, SERIALEM, UCSF CHIMERAX, REMARK 3 CRYOSPARC, ISOLDE, COOT REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 6GZE REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.230 REMARK 3 NUMBER OF PARTICLES : 296457 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9MI3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 16-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1000288146. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV-2 SPIKE PROTEIN WITH REMARK 245 WRAIR-2008 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.60 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : JEOL CRYO ARM 200 REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 100.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3200.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, H, K, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 VAL A 445 REMARK 465 GLY A 446 REMARK 465 LEU A 455 REMARK 465 PHE A 456 REMARK 465 ARG A 457 REMARK 465 LYS A 458 REMARK 465 SER A 459 REMARK 465 SER A 469 REMARK 465 THR A 470 REMARK 465 GLU A 471 REMARK 465 ILE A 472 REMARK 465 TYR A 473 REMARK 465 GLN A 474 REMARK 465 ALA A 475 REMARK 465 GLY A 476 REMARK 465 SER A 477 REMARK 465 THR A 478 REMARK 465 PRO A 479 REMARK 465 CYS A 480 REMARK 465 ASN A 481 REMARK 465 GLY A 482 REMARK 465 VAL A 483 REMARK 465 GLU A 484 REMARK 465 GLY A 485 REMARK 465 PHE A 486 REMARK 465 ASN A 487 REMARK 465 CYS A 488 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 THR A 678 REMARK 465 ASN A 679 REMARK 465 SER A 680 REMARK 465 PRO A 681 REMARK 465 GLY A 682 REMARK 465 SER A 683 REMARK 465 ALA A 684 REMARK 465 SER A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 GLY A 1209 REMARK 465 SER A 1210 REMARK 465 GLY A 1211 REMARK 465 TYR A 1212 REMARK 465 ILE A 1213 REMARK 465 PRO A 1214 REMARK 465 GLU A 1215 REMARK 465 ALA A 1216 REMARK 465 PRO A 1217 REMARK 465 ARG A 1218 REMARK 465 ASP A 1219 REMARK 465 GLY A 1220 REMARK 465 GLN A 1221 REMARK 465 ALA A 1222 REMARK 465 TYR A 1223 REMARK 465 VAL A 1224 REMARK 465 ARG A 1225 REMARK 465 LYS A 1226 REMARK 465 ASP A 1227 REMARK 465 GLY A 1228 REMARK 465 GLU A 1229 REMARK 465 TRP A 1230 REMARK 465 VAL A 1231 REMARK 465 LEU A 1232 REMARK 465 LEU A 1233 REMARK 465 SER A 1234 REMARK 465 THR A 1235 REMARK 465 PHE A 1236 REMARK 465 LEU A 1237 REMARK 465 GLY A 1238 REMARK 465 LEU A 1239 REMARK 465 GLU A 1240 REMARK 465 VAL A 1241 REMARK 465 LEU A 1242 REMARK 465 PHE A 1243 REMARK 465 GLN A 1244 REMARK 465 GLY A 1245 REMARK 465 PRO A 1246 REMARK 465 SER A 1247 REMARK 465 ALA A 1248 REMARK 465 TRP A 1249 REMARK 465 SER A 1250 REMARK 465 HIS A 1251 REMARK 465 PRO A 1252 REMARK 465 GLN A 1253 REMARK 465 PHE A 1254 REMARK 465 GLU A 1255 REMARK 465 LYS A 1256 REMARK 465 GLY A 1257 REMARK 465 GLY A 1258 REMARK 465 GLY A 1259 REMARK 465 SER A 1260 REMARK 465 GLY A 1261 REMARK 465 GLY A 1262 REMARK 465 GLY A 1263 REMARK 465 SER A 1264 REMARK 465 GLY A 1265 REMARK 465 GLY A 1266 REMARK 465 SER A 1267 REMARK 465 ALA A 1268 REMARK 465 TRP A 1269 REMARK 465 SER A 1270 REMARK 465 HIS A 1271 REMARK 465 PRO A 1272 REMARK 465 GLN A 1273 REMARK 465 PHE A 1274 REMARK 465 GLU A 1275 REMARK 465 LYS A 1276 REMARK 465 GLY A 1277 REMARK 465 SER A 1278 REMARK 465 HIS A 1279 REMARK 465 HIS A 1280 REMARK 465 HIS A 1281 REMARK 465 HIS A 1282 REMARK 465 HIS A 1283 REMARK 465 HIS A 1284 REMARK 465 HIS A 1285 REMARK 465 HIS A 1286 REMARK 465 ALA B 129 REMARK 465 SER B 130 REMARK 465 THR B 131 REMARK 465 LYS B 132 REMARK 465 GLY B 133 REMARK 465 PRO B 134 REMARK 465 SER B 135 REMARK 465 VAL B 136 REMARK 465 PHE B 137 REMARK 465 PRO B 138 REMARK 465 LEU B 139 REMARK 465 ALA B 140 REMARK 465 PRO B 141 REMARK 465 SER B 142 REMARK 465 SER B 143 REMARK 465 LYS B 144 REMARK 465 SER B 145 REMARK 465 THR B 146 REMARK 465 SER B 147 REMARK 465 GLY B 148 REMARK 465 GLY B 149 REMARK 465 THR B 150 REMARK 465 ALA B 151 REMARK 465 ALA B 152 REMARK 465 LEU B 153 REMARK 465 GLY B 154 REMARK 465 CYS B 155 REMARK 465 LEU B 156 REMARK 465 VAL B 157 REMARK 465 LYS B 158 REMARK 465 ASP B 159 REMARK 465 TYR B 160 REMARK 465 PHE B 161 REMARK 465 PRO B 162 REMARK 465 GLU B 163 REMARK 465 PRO B 164 REMARK 465 VAL B 165 REMARK 465 THR B 166 REMARK 465 VAL B 167 REMARK 465 SER B 168 REMARK 465 TRP B 169 REMARK 465 ASN B 170 REMARK 465 SER B 171 REMARK 465 GLY B 172 REMARK 465 ALA B 173 REMARK 465 LEU B 174 REMARK 465 THR B 175 REMARK 465 SER B 176 REMARK 465 GLY B 177 REMARK 465 VAL B 178 REMARK 465 HIS B 179 REMARK 465 THR B 180 REMARK 465 PHE B 181 REMARK 465 PRO B 182 REMARK 465 ALA B 183 REMARK 465 VAL B 184 REMARK 465 LEU B 185 REMARK 465 GLN B 186 REMARK 465 SER B 187 REMARK 465 SER B 188 REMARK 465 GLY B 189 REMARK 465 LEU B 190 REMARK 465 TYR B 191 REMARK 465 SER B 192 REMARK 465 LEU B 193 REMARK 465 SER B 194 REMARK 465 SER B 195 REMARK 465 VAL B 196 REMARK 465 VAL B 197 REMARK 465 THR B 198 REMARK 465 VAL B 199 REMARK 465 PRO B 200 REMARK 465 SER B 201 REMARK 465 SER B 202 REMARK 465 SER B 203 REMARK 465 LEU B 204 REMARK 465 GLY B 205 REMARK 465 THR B 206 REMARK 465 GLN B 207 REMARK 465 THR B 208 REMARK 465 TYR B 209 REMARK 465 ILE B 210 REMARK 465 CYS B 211 REMARK 465 ASN B 212 REMARK 465 VAL B 213 REMARK 465 ASN B 214 REMARK 465 HIS B 215 REMARK 465 LYS B 216 REMARK 465 PRO B 217 REMARK 465 SER B 218 REMARK 465 ASN B 219 REMARK 465 THR B 220 REMARK 465 LYS B 221 REMARK 465 VAL B 222 REMARK 465 ASP B 223 REMARK 465 LYS B 224 REMARK 465 LYS B 225 REMARK 465 VAL B 226 REMARK 465 GLU B 227 REMARK 465 PRO B 228 REMARK 465 LYS B 229 REMARK 465 SER B 230 REMARK 465 CYS B 231 REMARK 465 ASP B 232 REMARK 465 LYS B 233 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 GLY C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 VAL C 445 REMARK 465 GLY C 446 REMARK 465 LEU C 455 REMARK 465 PHE C 456 REMARK 465 ARG C 457 REMARK 465 LYS C 458 REMARK 465 SER C 459 REMARK 465 SER C 469 REMARK 465 THR C 470 REMARK 465 GLU C 471 REMARK 465 ILE C 472 REMARK 465 TYR C 473 REMARK 465 GLN C 474 REMARK 465 ALA C 475 REMARK 465 GLY C 476 REMARK 465 SER C 477 REMARK 465 THR C 478 REMARK 465 PRO C 479 REMARK 465 CYS C 480 REMARK 465 ASN C 481 REMARK 465 GLY C 482 REMARK 465 VAL C 483 REMARK 465 GLU C 484 REMARK 465 GLY C 485 REMARK 465 PHE C 486 REMARK 465 ASN C 487 REMARK 465 CYS C 488 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 THR C 678 REMARK 465 ASN C 679 REMARK 465 SER C 680 REMARK 465 PRO C 681 REMARK 465 GLY C 682 REMARK 465 SER C 683 REMARK 465 ALA C 684 REMARK 465 SER C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 CYS C 851 REMARK 465 ALA C 852 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 GLY C 1209 REMARK 465 SER C 1210 REMARK 465 GLY C 1211 REMARK 465 TYR C 1212 REMARK 465 ILE C 1213 REMARK 465 PRO C 1214 REMARK 465 GLU C 1215 REMARK 465 ALA C 1216 REMARK 465 PRO C 1217 REMARK 465 ARG C 1218 REMARK 465 ASP C 1219 REMARK 465 GLY C 1220 REMARK 465 GLN C 1221 REMARK 465 ALA C 1222 REMARK 465 TYR C 1223 REMARK 465 VAL C 1224 REMARK 465 ARG C 1225 REMARK 465 LYS C 1226 REMARK 465 ASP C 1227 REMARK 465 GLY C 1228 REMARK 465 GLU C 1229 REMARK 465 TRP C 1230 REMARK 465 VAL C 1231 REMARK 465 LEU C 1232 REMARK 465 LEU C 1233 REMARK 465 SER C 1234 REMARK 465 THR C 1235 REMARK 465 PHE C 1236 REMARK 465 LEU C 1237 REMARK 465 GLY C 1238 REMARK 465 LEU C 1239 REMARK 465 GLU C 1240 REMARK 465 VAL C 1241 REMARK 465 LEU C 1242 REMARK 465 PHE C 1243 REMARK 465 GLN C 1244 REMARK 465 GLY C 1245 REMARK 465 PRO C 1246 REMARK 465 SER C 1247 REMARK 465 ALA C 1248 REMARK 465 TRP C 1249 REMARK 465 SER C 1250 REMARK 465 HIS C 1251 REMARK 465 PRO C 1252 REMARK 465 GLN C 1253 REMARK 465 PHE C 1254 REMARK 465 GLU C 1255 REMARK 465 LYS C 1256 REMARK 465 GLY C 1257 REMARK 465 GLY C 1258 REMARK 465 GLY C 1259 REMARK 465 SER C 1260 REMARK 465 GLY C 1261 REMARK 465 GLY C 1262 REMARK 465 GLY C 1263 REMARK 465 SER C 1264 REMARK 465 GLY C 1265 REMARK 465 GLY C 1266 REMARK 465 SER C 1267 REMARK 465 ALA C 1268 REMARK 465 TRP C 1269 REMARK 465 SER C 1270 REMARK 465 HIS C 1271 REMARK 465 PRO C 1272 REMARK 465 GLN C 1273 REMARK 465 PHE C 1274 REMARK 465 GLU C 1275 REMARK 465 LYS C 1276 REMARK 465 GLY C 1277 REMARK 465 SER C 1278 REMARK 465 HIS C 1279 REMARK 465 HIS C 1280 REMARK 465 HIS C 1281 REMARK 465 HIS C 1282 REMARK 465 HIS C 1283 REMARK 465 HIS C 1284 REMARK 465 HIS C 1285 REMARK 465 HIS C 1286 REMARK 465 THR D 114 REMARK 465 VAL D 115 REMARK 465 ALA D 116 REMARK 465 ALA D 117 REMARK 465 PRO D 118 REMARK 465 SER D 119 REMARK 465 VAL D 120 REMARK 465 PHE D 121 REMARK 465 ILE D 122 REMARK 465 PHE D 123 REMARK 465 PRO D 124 REMARK 465 PRO D 125 REMARK 465 SER D 126 REMARK 465 ASP D 127 REMARK 465 GLU D 128 REMARK 465 GLN D 129 REMARK 465 LEU D 130 REMARK 465 LYS D 131 REMARK 465 SER D 132 REMARK 465 GLY D 133 REMARK 465 THR D 134 REMARK 465 ALA D 135 REMARK 465 SER D 136 REMARK 465 VAL D 137 REMARK 465 VAL D 138 REMARK 465 CYS D 139 REMARK 465 LEU D 140 REMARK 465 LEU D 141 REMARK 465 ASN D 142 REMARK 465 ASN D 143 REMARK 465 PHE D 144 REMARK 465 TYR D 145 REMARK 465 PRO D 146 REMARK 465 ARG D 147 REMARK 465 GLU D 148 REMARK 465 ALA D 149 REMARK 465 LYS D 150 REMARK 465 VAL D 151 REMARK 465 GLN D 152 REMARK 465 TRP D 153 REMARK 465 LYS D 154 REMARK 465 VAL D 155 REMARK 465 ASP D 156 REMARK 465 ASN D 157 REMARK 465 ALA D 158 REMARK 465 LEU D 159 REMARK 465 GLN D 160 REMARK 465 SER D 161 REMARK 465 GLY D 162 REMARK 465 ASN D 163 REMARK 465 SER D 164 REMARK 465 GLN D 165 REMARK 465 GLU D 166 REMARK 465 SER D 167 REMARK 465 VAL D 168 REMARK 465 THR D 169 REMARK 465 GLU D 170 REMARK 465 GLN D 171 REMARK 465 ASP D 172 REMARK 465 SER D 173 REMARK 465 LYS D 174 REMARK 465 ASP D 175 REMARK 465 SER D 176 REMARK 465 THR D 177 REMARK 465 TYR D 178 REMARK 465 SER D 179 REMARK 465 LEU D 180 REMARK 465 SER D 181 REMARK 465 SER D 182 REMARK 465 THR D 183 REMARK 465 LEU D 184 REMARK 465 THR D 185 REMARK 465 LEU D 186 REMARK 465 SER D 187 REMARK 465 LYS D 188 REMARK 465 ALA D 189 REMARK 465 ASP D 190 REMARK 465 TYR D 191 REMARK 465 GLU D 192 REMARK 465 LYS D 193 REMARK 465 HIS D 194 REMARK 465 LYS D 195 REMARK 465 VAL D 196 REMARK 465 TYR D 197 REMARK 465 ALA D 198 REMARK 465 CYS D 199 REMARK 465 GLU D 200 REMARK 465 VAL D 201 REMARK 465 THR D 202 REMARK 465 HIS D 203 REMARK 465 GLN D 204 REMARK 465 GLY D 205 REMARK 465 LEU D 206 REMARK 465 SER D 207 REMARK 465 SER D 208 REMARK 465 PRO D 209 REMARK 465 VAL D 210 REMARK 465 THR D 211 REMARK 465 LYS D 212 REMARK 465 SER D 213 REMARK 465 PHE D 214 REMARK 465 ASN D 215 REMARK 465 ARG D 216 REMARK 465 GLY D 217 REMARK 465 GLU D 218 REMARK 465 CYS D 219 REMARK 465 ALA E 129 REMARK 465 SER E 130 REMARK 465 THR E 131 REMARK 465 LYS E 132 REMARK 465 GLY E 133 REMARK 465 PRO E 134 REMARK 465 SER E 135 REMARK 465 VAL E 136 REMARK 465 PHE E 137 REMARK 465 PRO E 138 REMARK 465 LEU E 139 REMARK 465 ALA E 140 REMARK 465 PRO E 141 REMARK 465 SER E 142 REMARK 465 SER E 143 REMARK 465 LYS E 144 REMARK 465 SER E 145 REMARK 465 THR E 146 REMARK 465 SER E 147 REMARK 465 GLY E 148 REMARK 465 GLY E 149 REMARK 465 THR E 150 REMARK 465 ALA E 151 REMARK 465 ALA E 152 REMARK 465 LEU E 153 REMARK 465 GLY E 154 REMARK 465 CYS E 155 REMARK 465 LEU E 156 REMARK 465 VAL E 157 REMARK 465 LYS E 158 REMARK 465 ASP E 159 REMARK 465 TYR E 160 REMARK 465 PHE E 161 REMARK 465 PRO E 162 REMARK 465 GLU E 163 REMARK 465 PRO E 164 REMARK 465 VAL E 165 REMARK 465 THR E 166 REMARK 465 VAL E 167 REMARK 465 SER E 168 REMARK 465 TRP E 169 REMARK 465 ASN E 170 REMARK 465 SER E 171 REMARK 465 GLY E 172 REMARK 465 ALA E 173 REMARK 465 LEU E 174 REMARK 465 THR E 175 REMARK 465 SER E 176 REMARK 465 GLY E 177 REMARK 465 VAL E 178 REMARK 465 HIS E 179 REMARK 465 THR E 180 REMARK 465 PHE E 181 REMARK 465 PRO E 182 REMARK 465 ALA E 183 REMARK 465 VAL E 184 REMARK 465 LEU E 185 REMARK 465 GLN E 186 REMARK 465 SER E 187 REMARK 465 SER E 188 REMARK 465 GLY E 189 REMARK 465 LEU E 190 REMARK 465 TYR E 191 REMARK 465 SER E 192 REMARK 465 LEU E 193 REMARK 465 SER E 194 REMARK 465 SER E 195 REMARK 465 VAL E 196 REMARK 465 VAL E 197 REMARK 465 THR E 198 REMARK 465 VAL E 199 REMARK 465 PRO E 200 REMARK 465 SER E 201 REMARK 465 SER E 202 REMARK 465 SER E 203 REMARK 465 LEU E 204 REMARK 465 GLY E 205 REMARK 465 THR E 206 REMARK 465 GLN E 207 REMARK 465 THR E 208 REMARK 465 TYR E 209 REMARK 465 ILE E 210 REMARK 465 CYS E 211 REMARK 465 ASN E 212 REMARK 465 VAL E 213 REMARK 465 ASN E 214 REMARK 465 HIS E 215 REMARK 465 LYS E 216 REMARK 465 PRO E 217 REMARK 465 SER E 218 REMARK 465 ASN E 219 REMARK 465 THR E 220 REMARK 465 LYS E 221 REMARK 465 VAL E 222 REMARK 465 ASP E 223 REMARK 465 LYS E 224 REMARK 465 LYS E 225 REMARK 465 VAL E 226 REMARK 465 GLU E 227 REMARK 465 PRO E 228 REMARK 465 LYS E 229 REMARK 465 SER E 230 REMARK 465 CYS E 231 REMARK 465 ASP E 232 REMARK 465 LYS E 233 REMARK 465 THR F 114 REMARK 465 VAL F 115 REMARK 465 ALA F 116 REMARK 465 ALA F 117 REMARK 465 PRO F 118 REMARK 465 SER F 119 REMARK 465 VAL F 120 REMARK 465 PHE F 121 REMARK 465 ILE F 122 REMARK 465 PHE F 123 REMARK 465 PRO F 124 REMARK 465 PRO F 125 REMARK 465 SER F 126 REMARK 465 ASP F 127 REMARK 465 GLU F 128 REMARK 465 GLN F 129 REMARK 465 LEU F 130 REMARK 465 LYS F 131 REMARK 465 SER F 132 REMARK 465 GLY F 133 REMARK 465 THR F 134 REMARK 465 ALA F 135 REMARK 465 SER F 136 REMARK 465 VAL F 137 REMARK 465 VAL F 138 REMARK 465 CYS F 139 REMARK 465 LEU F 140 REMARK 465 LEU F 141 REMARK 465 ASN F 142 REMARK 465 ASN F 143 REMARK 465 PHE F 144 REMARK 465 TYR F 145 REMARK 465 PRO F 146 REMARK 465 ARG F 147 REMARK 465 GLU F 148 REMARK 465 ALA F 149 REMARK 465 LYS F 150 REMARK 465 VAL F 151 REMARK 465 GLN F 152 REMARK 465 TRP F 153 REMARK 465 LYS F 154 REMARK 465 VAL F 155 REMARK 465 ASP F 156 REMARK 465 ASN F 157 REMARK 465 ALA F 158 REMARK 465 LEU F 159 REMARK 465 GLN F 160 REMARK 465 SER F 161 REMARK 465 GLY F 162 REMARK 465 ASN F 163 REMARK 465 SER F 164 REMARK 465 GLN F 165 REMARK 465 GLU F 166 REMARK 465 SER F 167 REMARK 465 VAL F 168 REMARK 465 THR F 169 REMARK 465 GLU F 170 REMARK 465 GLN F 171 REMARK 465 ASP F 172 REMARK 465 SER F 173 REMARK 465 LYS F 174 REMARK 465 ASP F 175 REMARK 465 SER F 176 REMARK 465 THR F 177 REMARK 465 TYR F 178 REMARK 465 SER F 179 REMARK 465 LEU F 180 REMARK 465 SER F 181 REMARK 465 SER F 182 REMARK 465 THR F 183 REMARK 465 LEU F 184 REMARK 465 THR F 185 REMARK 465 LEU F 186 REMARK 465 SER F 187 REMARK 465 LYS F 188 REMARK 465 ALA F 189 REMARK 465 ASP F 190 REMARK 465 TYR F 191 REMARK 465 GLU F 192 REMARK 465 LYS F 193 REMARK 465 HIS F 194 REMARK 465 LYS F 195 REMARK 465 VAL F 196 REMARK 465 TYR F 197 REMARK 465 ALA F 198 REMARK 465 CYS F 199 REMARK 465 GLU F 200 REMARK 465 VAL F 201 REMARK 465 THR F 202 REMARK 465 HIS F 203 REMARK 465 GLN F 204 REMARK 465 GLY F 205 REMARK 465 LEU F 206 REMARK 465 SER F 207 REMARK 465 SER F 208 REMARK 465 PRO F 209 REMARK 465 VAL F 210 REMARK 465 THR F 211 REMARK 465 LYS F 212 REMARK 465 SER F 213 REMARK 465 PHE F 214 REMARK 465 ASN F 215 REMARK 465 ARG F 216 REMARK 465 GLY F 217 REMARK 465 GLU F 218 REMARK 465 CYS F 219 REMARK 465 ALA H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 LYS H 132 REMARK 465 GLY H 133 REMARK 465 PRO H 134 REMARK 465 SER H 135 REMARK 465 VAL H 136 REMARK 465 PHE H 137 REMARK 465 PRO H 138 REMARK 465 LEU H 139 REMARK 465 ALA H 140 REMARK 465 PRO H 141 REMARK 465 SER H 142 REMARK 465 SER H 143 REMARK 465 LYS H 144 REMARK 465 SER H 145 REMARK 465 THR H 146 REMARK 465 SER H 147 REMARK 465 GLY H 148 REMARK 465 GLY H 149 REMARK 465 THR H 150 REMARK 465 ALA H 151 REMARK 465 ALA H 152 REMARK 465 LEU H 153 REMARK 465 GLY H 154 REMARK 465 CYS H 155 REMARK 465 LEU H 156 REMARK 465 VAL H 157 REMARK 465 LYS H 158 REMARK 465 ASP H 159 REMARK 465 TYR H 160 REMARK 465 PHE H 161 REMARK 465 PRO H 162 REMARK 465 GLU H 163 REMARK 465 PRO H 164 REMARK 465 VAL H 165 REMARK 465 THR H 166 REMARK 465 VAL H 167 REMARK 465 SER H 168 REMARK 465 TRP H 169 REMARK 465 ASN H 170 REMARK 465 SER H 171 REMARK 465 GLY H 172 REMARK 465 ALA H 173 REMARK 465 LEU H 174 REMARK 465 THR H 175 REMARK 465 SER H 176 REMARK 465 GLY H 177 REMARK 465 VAL H 178 REMARK 465 HIS H 179 REMARK 465 THR H 180 REMARK 465 PHE H 181 REMARK 465 PRO H 182 REMARK 465 ALA H 183 REMARK 465 VAL H 184 REMARK 465 LEU H 185 REMARK 465 GLN H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 GLY H 189 REMARK 465 LEU H 190 REMARK 465 TYR H 191 REMARK 465 SER H 192 REMARK 465 LEU H 193 REMARK 465 SER H 194 REMARK 465 SER H 195 REMARK 465 VAL H 196 REMARK 465 VAL H 197 REMARK 465 THR H 198 REMARK 465 VAL H 199 REMARK 465 PRO H 200 REMARK 465 SER H 201 REMARK 465 SER H 202 REMARK 465 SER H 203 REMARK 465 LEU H 204 REMARK 465 GLY H 205 REMARK 465 THR H 206 REMARK 465 GLN H 207 REMARK 465 THR H 208 REMARK 465 TYR H 209 REMARK 465 ILE H 210 REMARK 465 CYS H 211 REMARK 465 ASN H 212 REMARK 465 VAL H 213 REMARK 465 ASN H 214 REMARK 465 HIS H 215 REMARK 465 LYS H 216 REMARK 465 PRO H 217 REMARK 465 SER H 218 REMARK 465 ASN H 219 REMARK 465 THR H 220 REMARK 465 LYS H 221 REMARK 465 VAL H 222 REMARK 465 ASP H 223 REMARK 465 LYS H 224 REMARK 465 LYS H 225 REMARK 465 VAL H 226 REMARK 465 GLU H 227 REMARK 465 PRO H 228 REMARK 465 LYS H 229 REMARK 465 SER H 230 REMARK 465 CYS H 231 REMARK 465 ASP H 232 REMARK 465 LYS H 233 REMARK 465 GLN K 14 REMARK 465 THR K 250 REMARK 465 PRO K 251 REMARK 465 GLY K 252 REMARK 465 ASP K 253 REMARK 465 SER K 254 REMARK 465 SER K 255 REMARK 465 SER K 256 REMARK 465 VAL K 445 REMARK 465 GLY K 446 REMARK 465 LEU K 455 REMARK 465 PHE K 456 REMARK 465 ARG K 457 REMARK 465 LYS K 458 REMARK 465 SER K 459 REMARK 465 SER K 469 REMARK 465 THR K 470 REMARK 465 GLU K 471 REMARK 465 ILE K 472 REMARK 465 TYR K 473 REMARK 465 GLN K 474 REMARK 465 ALA K 475 REMARK 465 GLY K 476 REMARK 465 SER K 477 REMARK 465 THR K 478 REMARK 465 PRO K 479 REMARK 465 CYS K 480 REMARK 465 ASN K 481 REMARK 465 GLY K 482 REMARK 465 VAL K 483 REMARK 465 GLU K 484 REMARK 465 GLY K 485 REMARK 465 PHE K 486 REMARK 465 ASN K 487 REMARK 465 CYS K 488 REMARK 465 ALA K 626 REMARK 465 ASP K 627 REMARK 465 GLN K 628 REMARK 465 LEU K 629 REMARK 465 THR K 630 REMARK 465 PRO K 631 REMARK 465 THR K 632 REMARK 465 THR K 678 REMARK 465 ASN K 679 REMARK 465 SER K 680 REMARK 465 PRO K 681 REMARK 465 GLY K 682 REMARK 465 SER K 683 REMARK 465 ALA K 684 REMARK 465 SER K 685 REMARK 465 SER K 686 REMARK 465 VAL K 687 REMARK 465 ALA K 688 REMARK 465 ILE K 834 REMARK 465 LYS K 835 REMARK 465 GLN K 836 REMARK 465 TYR K 837 REMARK 465 GLY K 838 REMARK 465 ASP K 839 REMARK 465 CYS K 840 REMARK 465 LEU K 841 REMARK 465 GLY K 842 REMARK 465 ASP K 843 REMARK 465 ILE K 844 REMARK 465 ALA K 845 REMARK 465 ALA K 846 REMARK 465 ARG K 847 REMARK 465 ASP K 848 REMARK 465 LEU K 849 REMARK 465 ILE K 850 REMARK 465 CYS K 851 REMARK 465 ALA K 852 REMARK 465 GLN K 853 REMARK 465 PHE K 1148 REMARK 465 LYS K 1149 REMARK 465 GLU K 1150 REMARK 465 GLU K 1151 REMARK 465 LEU K 1152 REMARK 465 ASP K 1153 REMARK 465 LYS K 1154 REMARK 465 TYR K 1155 REMARK 465 PHE K 1156 REMARK 465 LYS K 1157 REMARK 465 ASN K 1158 REMARK 465 HIS K 1159 REMARK 465 THR K 1160 REMARK 465 SER K 1161 REMARK 465 PRO K 1162 REMARK 465 ASP K 1163 REMARK 465 VAL K 1164 REMARK 465 ASP K 1165 REMARK 465 LEU K 1166 REMARK 465 GLY K 1167 REMARK 465 ASP K 1168 REMARK 465 ILE K 1169 REMARK 465 SER K 1170 REMARK 465 GLY K 1171 REMARK 465 ILE K 1172 REMARK 465 ASN K 1173 REMARK 465 ALA K 1174 REMARK 465 SER K 1175 REMARK 465 VAL K 1176 REMARK 465 VAL K 1177 REMARK 465 ASN K 1178 REMARK 465 ILE K 1179 REMARK 465 GLN K 1180 REMARK 465 LYS K 1181 REMARK 465 GLU K 1182 REMARK 465 ILE K 1183 REMARK 465 ASP K 1184 REMARK 465 ARG K 1185 REMARK 465 LEU K 1186 REMARK 465 ASN K 1187 REMARK 465 GLU K 1188 REMARK 465 VAL K 1189 REMARK 465 ALA K 1190 REMARK 465 LYS K 1191 REMARK 465 ASN K 1192 REMARK 465 LEU K 1193 REMARK 465 ASN K 1194 REMARK 465 GLU K 1195 REMARK 465 SER K 1196 REMARK 465 LEU K 1197 REMARK 465 ILE K 1198 REMARK 465 ASP K 1199 REMARK 465 LEU K 1200 REMARK 465 GLN K 1201 REMARK 465 GLU K 1202 REMARK 465 LEU K 1203 REMARK 465 GLY K 1204 REMARK 465 LYS K 1205 REMARK 465 TYR K 1206 REMARK 465 GLU K 1207 REMARK 465 GLN K 1208 REMARK 465 GLY K 1209 REMARK 465 SER K 1210 REMARK 465 GLY K 1211 REMARK 465 TYR K 1212 REMARK 465 ILE K 1213 REMARK 465 PRO K 1214 REMARK 465 GLU K 1215 REMARK 465 ALA K 1216 REMARK 465 PRO K 1217 REMARK 465 ARG K 1218 REMARK 465 ASP K 1219 REMARK 465 GLY K 1220 REMARK 465 GLN K 1221 REMARK 465 ALA K 1222 REMARK 465 TYR K 1223 REMARK 465 VAL K 1224 REMARK 465 ARG K 1225 REMARK 465 LYS K 1226 REMARK 465 ASP K 1227 REMARK 465 GLY K 1228 REMARK 465 GLU K 1229 REMARK 465 TRP K 1230 REMARK 465 VAL K 1231 REMARK 465 LEU K 1232 REMARK 465 LEU K 1233 REMARK 465 SER K 1234 REMARK 465 THR K 1235 REMARK 465 PHE K 1236 REMARK 465 LEU K 1237 REMARK 465 GLY K 1238 REMARK 465 LEU K 1239 REMARK 465 GLU K 1240 REMARK 465 VAL K 1241 REMARK 465 LEU K 1242 REMARK 465 PHE K 1243 REMARK 465 GLN K 1244 REMARK 465 GLY K 1245 REMARK 465 PRO K 1246 REMARK 465 SER K 1247 REMARK 465 ALA K 1248 REMARK 465 TRP K 1249 REMARK 465 SER K 1250 REMARK 465 HIS K 1251 REMARK 465 PRO K 1252 REMARK 465 GLN K 1253 REMARK 465 PHE K 1254 REMARK 465 GLU K 1255 REMARK 465 LYS K 1256 REMARK 465 GLY K 1257 REMARK 465 GLY K 1258 REMARK 465 GLY K 1259 REMARK 465 SER K 1260 REMARK 465 GLY K 1261 REMARK 465 GLY K 1262 REMARK 465 GLY K 1263 REMARK 465 SER K 1264 REMARK 465 GLY K 1265 REMARK 465 GLY K 1266 REMARK 465 SER K 1267 REMARK 465 ALA K 1268 REMARK 465 TRP K 1269 REMARK 465 SER K 1270 REMARK 465 HIS K 1271 REMARK 465 PRO K 1272 REMARK 465 GLN K 1273 REMARK 465 PHE K 1274 REMARK 465 GLU K 1275 REMARK 465 LYS K 1276 REMARK 465 GLY K 1277 REMARK 465 SER K 1278 REMARK 465 HIS K 1279 REMARK 465 HIS K 1280 REMARK 465 HIS K 1281 REMARK 465 HIS K 1282 REMARK 465 HIS K 1283 REMARK 465 HIS K 1284 REMARK 465 HIS K 1285 REMARK 465 HIS K 1286 REMARK 465 THR L 114 REMARK 465 VAL L 115 REMARK 465 ALA L 116 REMARK 465 ALA L 117 REMARK 465 PRO L 118 REMARK 465 SER L 119 REMARK 465 VAL L 120 REMARK 465 PHE L 121 REMARK 465 ILE L 122 REMARK 465 PHE L 123 REMARK 465 PRO L 124 REMARK 465 PRO L 125 REMARK 465 SER L 126 REMARK 465 ASP L 127 REMARK 465 GLU L 128 REMARK 465 GLN L 129 REMARK 465 LEU L 130 REMARK 465 LYS L 131 REMARK 465 SER L 132 REMARK 465 GLY L 133 REMARK 465 THR L 134 REMARK 465 ALA L 135 REMARK 465 SER L 136 REMARK 465 VAL L 137 REMARK 465 VAL L 138 REMARK 465 CYS L 139 REMARK 465 LEU L 140 REMARK 465 LEU L 141 REMARK 465 ASN L 142 REMARK 465 ASN L 143 REMARK 465 PHE L 144 REMARK 465 TYR L 145 REMARK 465 PRO L 146 REMARK 465 ARG L 147 REMARK 465 GLU L 148 REMARK 465 ALA L 149 REMARK 465 LYS L 150 REMARK 465 VAL L 151 REMARK 465 GLN L 152 REMARK 465 TRP L 153 REMARK 465 LYS L 154 REMARK 465 VAL L 155 REMARK 465 ASP L 156 REMARK 465 ASN L 157 REMARK 465 ALA L 158 REMARK 465 LEU L 159 REMARK 465 GLN L 160 REMARK 465 SER L 161 REMARK 465 GLY L 162 REMARK 465 ASN L 163 REMARK 465 SER L 164 REMARK 465 GLN L 165 REMARK 465 GLU L 166 REMARK 465 SER L 167 REMARK 465 VAL L 168 REMARK 465 THR L 169 REMARK 465 GLU L 170 REMARK 465 GLN L 171 REMARK 465 ASP L 172 REMARK 465 SER L 173 REMARK 465 LYS L 174 REMARK 465 ASP L 175 REMARK 465 SER L 176 REMARK 465 THR L 177 REMARK 465 TYR L 178 REMARK 465 SER L 179 REMARK 465 LEU L 180 REMARK 465 SER L 181 REMARK 465 SER L 182 REMARK 465 THR L 183 REMARK 465 LEU L 184 REMARK 465 THR L 185 REMARK 465 LEU L 186 REMARK 465 SER L 187 REMARK 465 LYS L 188 REMARK 465 ALA L 189 REMARK 465 ASP L 190 REMARK 465 TYR L 191 REMARK 465 GLU L 192 REMARK 465 LYS L 193 REMARK 465 HIS L 194 REMARK 465 LYS L 195 REMARK 465 VAL L 196 REMARK 465 TYR L 197 REMARK 465 ALA L 198 REMARK 465 CYS L 199 REMARK 465 GLU L 200 REMARK 465 VAL L 201 REMARK 465 THR L 202 REMARK 465 HIS L 203 REMARK 465 GLN L 204 REMARK 465 GLY L 205 REMARK 465 LEU L 206 REMARK 465 SER L 207 REMARK 465 SER L 208 REMARK 465 PRO L 209 REMARK 465 VAL L 210 REMARK 465 THR L 211 REMARK 465 LYS L 212 REMARK 465 SER L 213 REMARK 465 PHE L 214 REMARK 465 ASN L 215 REMARK 465 ARG L 216 REMARK 465 GLY L 217 REMARK 465 GLU L 218 REMARK 465 CYS L 219 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 PRO A 942 CG CD REMARK 470 PRO C 942 CG CD REMARK 470 PRO K 942 CG CD REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 HH TYR C 365 HZ PHE C 515 1.07 REMARK 500 HE1 PHE B 64 HH12 ARG B 87 1.08 REMARK 500 SG CYS A 738 SG CYS A 760 1.25 REMARK 500 HD2 ARG B 38 OD1 ASP B 90 1.31 REMARK 500 SG CYS K 131 SG CYS K 166 1.33 REMARK 500 SG CYS C 131 SG CYS C 166 1.47 REMARK 500 O ARG B 38 H GLU B 46 1.49 REMARK 500 HH TYR C 365 CZ PHE C 515 1.51 REMARK 500 OD2 ASP K 578 H THR K 581 1.53 REMARK 500 O GLU C 661 HH TYR C 695 1.54 REMARK 500 O GLU K 661 HH TYR K 695 1.54 REMARK 500 O GLN F 42 H ARG F 50 1.54 REMARK 500 O SER K 438 H ASP K 442 1.54 REMARK 500 OE1 GLN K 804 HE22 GLN K 935 1.55 REMARK 500 O SER E 33 H ALA E 99 1.56 REMARK 500 OE1 GLN C 804 HE22 GLN C 935 1.56 REMARK 500 H ASP H 52 O GLU H 57 1.56 REMARK 500 O SER A 758 HE21 GLN A 762 1.57 REMARK 500 O GLU K 406 H ILE K 410 1.58 REMARK 500 O TRP B 36 H GLY B 49 1.58 REMARK 500 HD21 ASN A 148 OD1 ASN A 149 1.58 REMARK 500 HH11 ARG B 38 OD1 ASP B 90 1.59 REMARK 500 O GLU A 661 HH TYR A 695 1.59 REMARK 500 O GLN D 42 H ARG D 50 1.59 REMARK 500 OH TYR A 37 HZ1 LYS A 195 1.59 REMARK 500 OG SER C 1123 HD21 ASN K 914 1.59 REMARK 500 OD2 ASP C 578 HG1 THR C 581 1.60 REMARK 500 NH1 ARG B 38 OD1 ASP B 90 1.83 REMARK 500 O THR C 108 OG1 THR C 236 1.90 REMARK 500 CD ARG B 38 OD1 ASP B 90 1.91 REMARK 500 CE1 PHE B 64 NH1 ARG B 87 1.97 REMARK 500 O GLY A 880 OG SER A 884 1.98 REMARK 500 CZ ARG B 38 OD1 ASP B 90 1.98 REMARK 500 NE ARG B 38 OD1 ASP B 90 1.98 REMARK 500 OG1 THR C 393 O GLU C 516 2.01 REMARK 500 O ASN A 99 NH1 ARG A 102 2.03 REMARK 500 O GLY C 880 OG SER C 884 2.03 REMARK 500 OG1 THR H 103 O PHE H 109 2.04 REMARK 500 OG SER H 33 O ALA H 99 2.08 REMARK 500 OH TYR A 37 NZ LYS A 195 2.09 REMARK 500 O ASN K 439 OG SER K 443 2.09 REMARK 500 O GLU C 661 OH TYR C 695 2.10 REMARK 500 OH TYR C 365 CE1 PHE C 515 2.10 REMARK 500 O SER H 7 OG1 THR H 122 2.10 REMARK 500 OE1 GLN D 6 OG1 THR D 107 2.13 REMARK 500 OH TYR C 365 CZ PHE C 515 2.14 REMARK 500 O ASN A 439 OG SER A 443 2.14 REMARK 500 O VAL C 83 NH2 ARG C 237 2.15 REMARK 500 O GLU K 661 OH TYR K 695 2.15 REMARK 500 OE1 GLN C 804 NE2 GLN C 935 2.16 REMARK 500 REMARK 500 THIS ENTRY HAS 60 CLOSE CONTACTS REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 THR A 29 141.58 -170.35 REMARK 500 ASP A 40 -149.88 67.36 REMARK 500 THR A 63 -177.93 -61.72 REMARK 500 ASP A 80 117.77 -161.58 REMARK 500 ASN A 87 -150.47 67.66 REMARK 500 THR A 95 17.63 -140.51 REMARK 500 SER A 112 28.74 46.33 REMARK 500 THR A 124 15.68 -141.08 REMARK 500 LYS A 147 -128.37 65.39 REMARK 500 MET A 153 142.60 -171.97 REMARK 500 ASN A 165 -12.41 74.75 REMARK 500 CYS A 166 64.95 39.49 REMARK 500 ASP A 198 -128.69 61.71 REMARK 500 SER A 221 141.62 -171.41 REMARK 500 SER A 247 54.56 -90.68 REMARK 500 PRO A 272 49.02 -86.43 REMARK 500 ARG A 273 107.42 -162.61 REMARK 500 PHE A 275 -64.11 -94.11 REMARK 500 PRO A 337 49.43 -85.46 REMARK 500 ASP A 420 -9.17 77.32 REMARK 500 TYR A 453 115.41 -160.91 REMARK 500 ASP A 571 -5.68 75.09 REMARK 500 ASP A 574 -53.20 -120.48 REMARK 500 SER A 605 153.45 65.74 REMARK 500 TYR A 636 5.72 -67.36 REMARK 500 SER A 637 162.83 64.32 REMARK 500 ASN A 709 0.89 -66.07 REMARK 500 ASN A 710 53.10 -142.80 REMARK 500 ALA A 783 30.07 -88.18 REMARK 500 ALA A 829 150.04 68.20 REMARK 500 GLN A 965 -8.77 -56.78 REMARK 500 PHE A 970 25.33 46.48 REMARK 500 ALA A1070 -57.76 -122.26 REMARK 500 SER A1123 107.41 -165.32 REMARK 500 ARG B 107 56.64 -92.09 REMARK 500 SER C 45 14.82 56.88 REMARK 500 HIS C 49 104.61 -160.69 REMARK 500 ASN C 87 -156.19 62.15 REMARK 500 LEU C 141 171.95 64.42 REMARK 500 SER C 151 -60.98 -91.23 REMARK 500 GLU C 154 55.56 -92.37 REMARK 500 SER C 172 -169.97 -165.44 REMARK 500 LEU C 176 48.50 -88.32 REMARK 500 ASP C 198 143.17 -172.90 REMARK 500 ASN C 211 -35.99 -130.59 REMARK 500 PRO C 217 -175.61 -69.97 REMARK 500 SER C 221 117.57 -161.39 REMARK 500 TYR C 248 58.58 39.16 REMARK 500 SER C 316 -168.23 -168.52 REMARK 500 SER C 530 -178.82 -69.86 REMARK 500 REMARK 500 THIS ENTRY HAS 100 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-48284 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE PROTEIN IN COMPLEX WITH REMARK 900 NEUTRALIZING HUMAN ANTIBODY WRAIR-2008 DBREF 9MI3 A 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9MI3 B 1 233 PDB 9MI3 9MI3 1 233 DBREF 9MI3 C 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9MI3 D 1 219 PDB 9MI3 9MI3 1 219 DBREF 9MI3 E 1 233 PDB 9MI3 9MI3 1 233 DBREF 9MI3 F 1 219 PDB 9MI3 9MI3 1 219 DBREF 9MI3 H 1 233 PDB 9MI3 9MI3 1 233 DBREF 9MI3 K 14 1208 UNP P0DTC2 SPIKE_SARS2 14 1208 DBREF 9MI3 L 1 219 PDB 9MI3 9MI3 1 219 SEQADV 9MI3 GLY A 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9MI3 SER A 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9MI3 SER A 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9MI3 PRO A 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9MI3 PRO A 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9MI3 PRO A 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9MI3 PRO A 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9MI3 PRO A 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9MI3 PRO A 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9MI3 GLY A 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TYR A 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ILE A 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ARG A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ASP A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TYR A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ARG A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ASP A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 THR A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA A 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP A 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO A 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN A 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE A 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU A 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS A 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY A 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER A 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS A 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9MI3 SER C 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9MI3 SER C 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9MI3 PRO C 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9MI3 PRO C 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9MI3 PRO C 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9MI3 PRO C 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9MI3 PRO C 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9MI3 PRO C 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9MI3 GLY C 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TYR C 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ILE C 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO C 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU C 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA C 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO C 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ARG C 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ASP C 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN C 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA C 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TYR C 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL C 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ARG C 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS C 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ASP C 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU C 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP C 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL C 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU C 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU C 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 THR C 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE C 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU C 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU C 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU C 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL C 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU C 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE C 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN C 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO C 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA C 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP C 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO C 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN C 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE C 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU C 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS C 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA C 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP C 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO C 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN C 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE C 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU C 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS C 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY C 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER C 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS C 1286 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 682 UNP P0DTC2 ARG 682 CONFLICT SEQADV 9MI3 SER K 683 UNP P0DTC2 ARG 683 CONFLICT SEQADV 9MI3 SER K 685 UNP P0DTC2 ARG 685 CONFLICT SEQADV 9MI3 PRO K 817 UNP P0DTC2 PHE 817 CONFLICT SEQADV 9MI3 PRO K 892 UNP P0DTC2 ALA 892 CONFLICT SEQADV 9MI3 PRO K 899 UNP P0DTC2 ALA 899 CONFLICT SEQADV 9MI3 PRO K 942 UNP P0DTC2 ALA 942 CONFLICT SEQADV 9MI3 PRO K 986 UNP P0DTC2 LYS 986 CONFLICT SEQADV 9MI3 PRO K 987 UNP P0DTC2 VAL 987 CONFLICT SEQADV 9MI3 GLY K 1209 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1210 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1211 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TYR K 1212 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ILE K 1213 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO K 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU K 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA K 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO K 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ARG K 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ASP K 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN K 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA K 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TYR K 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL K 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ARG K 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS K 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ASP K 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU K 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP K 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL K 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU K 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU K 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 THR K 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE K 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU K 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU K 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU K 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 VAL K 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LEU K 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE K 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN K 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO K 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA K 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP K 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO K 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN K 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE K 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU K 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS K 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1260 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1261 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1262 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1263 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1264 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1265 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1266 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1267 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 ALA K 1268 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 TRP K 1269 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1270 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1271 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PRO K 1272 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLN K 1273 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 PHE K 1274 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLU K 1275 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 LYS K 1276 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 GLY K 1277 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 SER K 1278 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1279 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1280 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1281 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1282 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1283 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1284 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1285 UNP P0DTC2 EXPRESSION TAG SEQADV 9MI3 HIS K 1286 UNP P0DTC2 EXPRESSION TAG SEQRES 1 A 1273 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 2 A 1273 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 3 A 1273 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 4 A 1273 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 5 A 1273 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 6 A 1273 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 7 A 1273 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 8 A 1273 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 9 A 1273 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 10 A 1273 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 11 A 1273 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 12 A 1273 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 13 A 1273 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 14 A 1273 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 15 A 1273 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 16 A 1273 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 17 A 1273 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 18 A 1273 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 19 A 1273 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 20 A 1273 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 21 A 1273 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 22 A 1273 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 23 A 1273 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 24 A 1273 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 25 A 1273 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 26 A 1273 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 27 A 1273 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 28 A 1273 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 29 A 1273 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 30 A 1273 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 31 A 1273 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 32 A 1273 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 33 A 1273 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 34 A 1273 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 35 A 1273 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 36 A 1273 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 37 A 1273 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 38 A 1273 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 39 A 1273 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 40 A 1273 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 41 A 1273 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 42 A 1273 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 43 A 1273 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 44 A 1273 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 45 A 1273 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 46 A 1273 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 47 A 1273 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 48 A 1273 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 49 A 1273 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 50 A 1273 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 51 A 1273 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 52 A 1273 GLN THR ASN SER PRO GLY SER ALA SER SER VAL ALA SER SEQRES 53 A 1273 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 54 A 1273 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 55 A 1273 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 56 A 1273 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 57 A 1273 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 58 A 1273 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 59 A 1273 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 60 A 1273 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 61 A 1273 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 62 A 1273 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 63 A 1273 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 64 A 1273 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 65 A 1273 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 66 A 1273 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 67 A 1273 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 68 A 1273 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 69 A 1273 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 70 A 1273 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 71 A 1273 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 72 A 1273 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 73 A 1273 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 74 A 1273 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 75 A 1273 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 76 A 1273 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 77 A 1273 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 78 A 1273 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 79 A 1273 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 80 A 1273 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 81 A 1273 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 82 A 1273 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 83 A 1273 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 84 A 1273 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 85 A 1273 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 86 A 1273 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 87 A 1273 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 88 A 1273 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 89 A 1273 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 90 A 1273 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 91 A 1273 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 92 A 1273 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN GLY SEQRES 93 A 1273 SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA SEQRES 94 A 1273 TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR SEQRES 95 A 1273 PHE LEU GLY LEU GLU VAL LEU PHE GLN GLY PRO SER ALA SEQRES 96 A 1273 TRP SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY SEQRES 97 A 1273 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 98 A 1273 GLU LYS GLY SER HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 B 233 GLN VAL ARG VAL VAL GLN SER GLY ALA GLU VAL LYS ASN SEQRES 2 B 233 PRO GLY ALA SER VAL LYS VAL SER CYS LYS VAL SER GLY SEQRES 3 B 233 TYR THR LEU THR GLU LEU SER ILE HIS TRP VAL ARG GLN SEQRES 4 B 233 ALA PRO GLY ASN GLY LEU GLU TRP MET GLY GLY PHE ASP SEQRES 5 B 233 PRO GLU ASP GLY GLU THR ILE TYR ALA GLN LYS PHE GLN SEQRES 6 B 233 GLY ARG VAL THR MET THR GLU ASP THR SER THR ASP THR SEQRES 7 B 233 ALA TYR MET GLU LEU SER SER LEU ARG SER ASP ASP THR SEQRES 8 B 233 ALA VAL TYR TYR CYS ALA THR ALA GLY ALA ILE THR GLY SEQRES 9 B 233 THR PRO ARG ASN PHE TYR TYR TYR TYR GLY MET ASP VAL SEQRES 10 B 233 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 B 233 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 B 233 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 B 233 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 B 233 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 B 233 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 B 233 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 B 233 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 B 233 VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS SEQRES 1 C 1273 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 2 C 1273 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 3 C 1273 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 4 C 1273 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 5 C 1273 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 6 C 1273 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 7 C 1273 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 8 C 1273 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 9 C 1273 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 10 C 1273 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 11 C 1273 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 12 C 1273 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 13 C 1273 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 14 C 1273 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 15 C 1273 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 16 C 1273 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 17 C 1273 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 18 C 1273 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 19 C 1273 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 20 C 1273 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 21 C 1273 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 22 C 1273 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 23 C 1273 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 24 C 1273 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 25 C 1273 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 26 C 1273 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 27 C 1273 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 28 C 1273 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 29 C 1273 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 30 C 1273 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 31 C 1273 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 32 C 1273 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 33 C 1273 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 34 C 1273 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 35 C 1273 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 36 C 1273 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 37 C 1273 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 38 C 1273 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 39 C 1273 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 40 C 1273 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 41 C 1273 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 42 C 1273 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 43 C 1273 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 44 C 1273 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 45 C 1273 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 46 C 1273 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 47 C 1273 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 48 C 1273 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 49 C 1273 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 50 C 1273 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 51 C 1273 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 52 C 1273 GLN THR ASN SER PRO GLY SER ALA SER SER VAL ALA SER SEQRES 53 C 1273 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 54 C 1273 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 55 C 1273 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 56 C 1273 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 57 C 1273 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 58 C 1273 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 59 C 1273 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 60 C 1273 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 61 C 1273 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 62 C 1273 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 63 C 1273 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 64 C 1273 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 65 C 1273 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 66 C 1273 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 67 C 1273 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 68 C 1273 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 69 C 1273 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 70 C 1273 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 71 C 1273 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 72 C 1273 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 73 C 1273 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 74 C 1273 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 75 C 1273 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 76 C 1273 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 77 C 1273 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 78 C 1273 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 79 C 1273 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 80 C 1273 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 81 C 1273 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 82 C 1273 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 83 C 1273 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 84 C 1273 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 85 C 1273 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 86 C 1273 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 87 C 1273 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 88 C 1273 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 89 C 1273 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 90 C 1273 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 91 C 1273 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 92 C 1273 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN GLY SEQRES 93 C 1273 SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA SEQRES 94 C 1273 TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR SEQRES 95 C 1273 PHE LEU GLY LEU GLU VAL LEU PHE GLN GLY PRO SER ALA SEQRES 96 C 1273 TRP SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY SEQRES 97 C 1273 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 98 C 1273 GLU LYS GLY SER HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 D 219 ASP ILE VAL MET THR GLN THR PRO LEU SER SER PRO VAL SEQRES 2 D 219 THR LEU GLY GLN PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 D 219 GLN SER LEU VAL HIS SER ASP GLY ASN THR TYR LEU SER SEQRES 4 D 219 TRP LEU GLN GLN ARG PRO GLY GLN PRO PRO ARG LEU LEU SEQRES 5 D 219 ILE TYR LYS ILE SER ASN ARG PHE SER GLY VAL PRO ASP SEQRES 6 D 219 ARG PHE SER GLY SER GLY ALA GLY THR ASP PHE THR LEU SEQRES 7 D 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 D 219 TYR CYS MET GLN VAL THR GLN PHE PRO TYR THR PHE GLY SEQRES 9 D 219 GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 D 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 D 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 D 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 D 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 D 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 D 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 D 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 D 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 E 233 GLN VAL ARG VAL VAL GLN SER GLY ALA GLU VAL LYS ASN SEQRES 2 E 233 PRO GLY ALA SER VAL LYS VAL SER CYS LYS VAL SER GLY SEQRES 3 E 233 TYR THR LEU THR GLU LEU SER ILE HIS TRP VAL ARG GLN SEQRES 4 E 233 ALA PRO GLY ASN GLY LEU GLU TRP MET GLY GLY PHE ASP SEQRES 5 E 233 PRO GLU ASP GLY GLU THR ILE TYR ALA GLN LYS PHE GLN SEQRES 6 E 233 GLY ARG VAL THR MET THR GLU ASP THR SER THR ASP THR SEQRES 7 E 233 ALA TYR MET GLU LEU SER SER LEU ARG SER ASP ASP THR SEQRES 8 E 233 ALA VAL TYR TYR CYS ALA THR ALA GLY ALA ILE THR GLY SEQRES 9 E 233 THR PRO ARG ASN PHE TYR TYR TYR TYR GLY MET ASP VAL SEQRES 10 E 233 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 E 233 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 E 233 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 E 233 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 E 233 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 E 233 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 E 233 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 E 233 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 E 233 VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS SEQRES 1 F 219 ASP ILE VAL MET THR GLN THR PRO LEU SER SER PRO VAL SEQRES 2 F 219 THR LEU GLY GLN PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 F 219 GLN SER LEU VAL HIS SER ASP GLY ASN THR TYR LEU SER SEQRES 4 F 219 TRP LEU GLN GLN ARG PRO GLY GLN PRO PRO ARG LEU LEU SEQRES 5 F 219 ILE TYR LYS ILE SER ASN ARG PHE SER GLY VAL PRO ASP SEQRES 6 F 219 ARG PHE SER GLY SER GLY ALA GLY THR ASP PHE THR LEU SEQRES 7 F 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 F 219 TYR CYS MET GLN VAL THR GLN PHE PRO TYR THR PHE GLY SEQRES 9 F 219 GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 F 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 F 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 F 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 F 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 F 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 F 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 F 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 F 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 H 233 GLN VAL ARG VAL VAL GLN SER GLY ALA GLU VAL LYS ASN SEQRES 2 H 233 PRO GLY ALA SER VAL LYS VAL SER CYS LYS VAL SER GLY SEQRES 3 H 233 TYR THR LEU THR GLU LEU SER ILE HIS TRP VAL ARG GLN SEQRES 4 H 233 ALA PRO GLY ASN GLY LEU GLU TRP MET GLY GLY PHE ASP SEQRES 5 H 233 PRO GLU ASP GLY GLU THR ILE TYR ALA GLN LYS PHE GLN SEQRES 6 H 233 GLY ARG VAL THR MET THR GLU ASP THR SER THR ASP THR SEQRES 7 H 233 ALA TYR MET GLU LEU SER SER LEU ARG SER ASP ASP THR SEQRES 8 H 233 ALA VAL TYR TYR CYS ALA THR ALA GLY ALA ILE THR GLY SEQRES 9 H 233 THR PRO ARG ASN PHE TYR TYR TYR TYR GLY MET ASP VAL SEQRES 10 H 233 TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA SER SEQRES 11 H 233 THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER SEQRES 12 H 233 LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU SEQRES 13 H 233 VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP SEQRES 14 H 233 ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO SEQRES 15 H 233 ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER SEQRES 16 H 233 VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR SEQRES 17 H 233 TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS SEQRES 18 H 233 VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS SEQRES 1 K 1273 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 2 K 1273 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 3 K 1273 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 4 K 1273 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 5 K 1273 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 6 K 1273 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 7 K 1273 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 8 K 1273 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 9 K 1273 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 10 K 1273 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 11 K 1273 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 12 K 1273 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 13 K 1273 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 14 K 1273 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 15 K 1273 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 16 K 1273 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 17 K 1273 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 18 K 1273 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 19 K 1273 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 20 K 1273 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 21 K 1273 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 22 K 1273 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 23 K 1273 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 24 K 1273 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 25 K 1273 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 26 K 1273 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 27 K 1273 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 28 K 1273 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 29 K 1273 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 30 K 1273 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 31 K 1273 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 32 K 1273 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 33 K 1273 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 34 K 1273 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 35 K 1273 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 36 K 1273 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 37 K 1273 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 38 K 1273 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 39 K 1273 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 40 K 1273 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 41 K 1273 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 42 K 1273 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 43 K 1273 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 44 K 1273 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 45 K 1273 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 46 K 1273 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 47 K 1273 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 48 K 1273 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 49 K 1273 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 50 K 1273 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 51 K 1273 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 52 K 1273 GLN THR ASN SER PRO GLY SER ALA SER SER VAL ALA SER SEQRES 53 K 1273 GLN SER ILE ILE ALA TYR THR MET SER LEU GLY ALA GLU SEQRES 54 K 1273 ASN SER VAL ALA TYR SER ASN ASN SER ILE ALA ILE PRO SEQRES 55 K 1273 THR ASN PHE THR ILE SER VAL THR THR GLU ILE LEU PRO SEQRES 56 K 1273 VAL SER MET THR LYS THR SER VAL ASP CYS THR MET TYR SEQRES 57 K 1273 ILE CYS GLY ASP SER THR GLU CYS SER ASN LEU LEU LEU SEQRES 58 K 1273 GLN TYR GLY SER PHE CYS THR GLN LEU ASN ARG ALA LEU SEQRES 59 K 1273 THR GLY ILE ALA VAL GLU GLN ASP LYS ASN THR GLN GLU SEQRES 60 K 1273 VAL PHE ALA GLN VAL LYS GLN ILE TYR LYS THR PRO PRO SEQRES 61 K 1273 ILE LYS ASP PHE GLY GLY PHE ASN PHE SER GLN ILE LEU SEQRES 62 K 1273 PRO ASP PRO SER LYS PRO SER LYS ARG SER PRO ILE GLU SEQRES 63 K 1273 ASP LEU LEU PHE ASN LYS VAL THR LEU ALA ASP ALA GLY SEQRES 64 K 1273 PHE ILE LYS GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA SEQRES 65 K 1273 ALA ARG ASP LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU SEQRES 66 K 1273 THR VAL LEU PRO PRO LEU LEU THR ASP GLU MET ILE ALA SEQRES 67 K 1273 GLN TYR THR SER ALA LEU LEU ALA GLY THR ILE THR SER SEQRES 68 K 1273 GLY TRP THR PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO SEQRES 69 K 1273 PHE PRO MET GLN MET ALA TYR ARG PHE ASN GLY ILE GLY SEQRES 70 K 1273 VAL THR GLN ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE SEQRES 71 K 1273 ALA ASN GLN PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SEQRES 72 K 1273 SER LEU SER SER THR PRO SER ALA LEU GLY LYS LEU GLN SEQRES 73 K 1273 ASP VAL VAL ASN GLN ASN ALA GLN ALA LEU ASN THR LEU SEQRES 74 K 1273 VAL LYS GLN LEU SER SER ASN PHE GLY ALA ILE SER SER SEQRES 75 K 1273 VAL LEU ASN ASP ILE LEU SER ARG LEU ASP PRO PRO GLU SEQRES 76 K 1273 ALA GLU VAL GLN ILE ASP ARG LEU ILE THR GLY ARG LEU SEQRES 77 K 1273 GLN SER LEU GLN THR TYR VAL THR GLN GLN LEU ILE ARG SEQRES 78 K 1273 ALA ALA GLU ILE ARG ALA SER ALA ASN LEU ALA ALA THR SEQRES 79 K 1273 LYS MET SER GLU CYS VAL LEU GLY GLN SER LYS ARG VAL SEQRES 80 K 1273 ASP PHE CYS GLY LYS GLY TYR HIS LEU MET SER PHE PRO SEQRES 81 K 1273 GLN SER ALA PRO HIS GLY VAL VAL PHE LEU HIS VAL THR SEQRES 82 K 1273 TYR VAL PRO ALA GLN GLU LYS ASN PHE THR THR ALA PRO SEQRES 83 K 1273 ALA ILE CYS HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU SEQRES 84 K 1273 GLY VAL PHE VAL SER ASN GLY THR HIS TRP PHE VAL THR SEQRES 85 K 1273 GLN ARG ASN PHE TYR GLU PRO GLN ILE ILE THR THR ASP SEQRES 86 K 1273 ASN THR PHE VAL SER GLY ASN CYS ASP VAL VAL ILE GLY SEQRES 87 K 1273 ILE VAL ASN ASN THR VAL TYR ASP PRO LEU GLN PRO GLU SEQRES 88 K 1273 LEU ASP SER PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS SEQRES 89 K 1273 ASN HIS THR SER PRO ASP VAL ASP LEU GLY ASP ILE SER SEQRES 90 K 1273 GLY ILE ASN ALA SER VAL VAL ASN ILE GLN LYS GLU ILE SEQRES 91 K 1273 ASP ARG LEU ASN GLU VAL ALA LYS ASN LEU ASN GLU SER SEQRES 92 K 1273 LEU ILE ASP LEU GLN GLU LEU GLY LYS TYR GLU GLN GLY SEQRES 93 K 1273 SER GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA SEQRES 94 K 1273 TYR VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR SEQRES 95 K 1273 PHE LEU GLY LEU GLU VAL LEU PHE GLN GLY PRO SER ALA SEQRES 96 K 1273 TRP SER HIS PRO GLN PHE GLU LYS GLY GLY GLY SER GLY SEQRES 97 K 1273 GLY GLY SER GLY GLY SER ALA TRP SER HIS PRO GLN PHE SEQRES 98 K 1273 GLU LYS GLY SER HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 L 219 ASP ILE VAL MET THR GLN THR PRO LEU SER SER PRO VAL SEQRES 2 L 219 THR LEU GLY GLN PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 L 219 GLN SER LEU VAL HIS SER ASP GLY ASN THR TYR LEU SER SEQRES 4 L 219 TRP LEU GLN GLN ARG PRO GLY GLN PRO PRO ARG LEU LEU SEQRES 5 L 219 ILE TYR LYS ILE SER ASN ARG PHE SER GLY VAL PRO ASP SEQRES 6 L 219 ARG PHE SER GLY SER GLY ALA GLY THR ASP PHE THR LEU SEQRES 7 L 219 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 L 219 TYR CYS MET GLN VAL THR GLN PHE PRO TYR THR PHE GLY SEQRES 9 L 219 GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA ALA SEQRES 10 L 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 L 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 L 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 L 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 L 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 L 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 L 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 L 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS HET NAG A1301 27 HET NAG A1302 27 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG A1307 14 HET NAG A1308 14 HET NAG A1309 14 HET NAG A1310 14 HET NAG A1311 14 HET NAG C1301 27 HET NAG C1302 27 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HET NAG C1307 14 HET NAG C1308 14 HET NAG C1309 14 HET NAG C1310 14 HET NAG K1301 27 HET NAG K1302 14 HET NAG K1303 14 HET NAG K1304 14 HET NAG K1305 14 HET NAG K1306 14 HET NAG K1307 14 HET NAG K1308 14 HET NAG K1309 14 HET NAG K1310 14 HET NAG K1311 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 10 NAG 32(C8 H15 N O6) HELIX 1 AA1 GLY A 75 PHE A 79 5 5 HELIX 2 AA2 ASP A 294 LYS A 304 1 11 HELIX 3 AA3 PRO A 337 ASN A 343 1 7 HELIX 4 AA4 SER A 349 TRP A 353 5 5 HELIX 5 AA5 ASP A 364 SER A 371 1 8 HELIX 6 AA6 PRO A 384 ASN A 388 5 5 HELIX 7 AA7 ASP A 405 ILE A 410 1 6 HELIX 8 AA8 SER A 438 SER A 443 1 6 HELIX 9 AA9 THR A 618 ALA A 623 1 6 HELIX 10 AB1 ASP A 737 GLY A 744 1 8 HELIX 11 AB2 SER A 746 LEU A 753 1 8 HELIX 12 AB3 SER A 758 PHE A 782 1 25 HELIX 13 AB4 ALA A 783 VAL A 785 5 3 HELIX 14 AB5 SER A 816 VAL A 826 1 11 HELIX 15 AB6 GLN A 853 ASN A 856 5 4 HELIX 16 AB7 THR A 866 SER A 884 1 19 HELIX 17 AB8 PRO A 897 GLY A 908 1 12 HELIX 18 AB9 GLN A 913 ASN A 919 1 7 HELIX 19 AC1 ASN A 919 THR A 941 1 23 HELIX 20 AC2 LEU A 945 GLN A 965 1 21 HELIX 21 AC3 VAL A 976 LEU A 984 1 9 HELIX 22 AC4 ASP A 985 CYS A 1032 1 48 HELIX 23 AC5 THR A 1116 ASP A 1118 5 3 HELIX 24 AC6 PRO A 1140 SER A 1147 1 8 HELIX 25 AC7 THR B 28 THR B 30 5 3 HELIX 26 AC8 ASP C 294 LYS C 304 1 11 HELIX 27 AC9 PRO C 337 ASN C 343 1 7 HELIX 28 AD1 ASP C 364 SER C 371 1 8 HELIX 29 AD2 SER C 383 ASN C 388 1 6 HELIX 30 AD3 ASP C 405 ILE C 410 1 6 HELIX 31 AD4 GLY C 416 ASN C 422 1 7 HELIX 32 AD5 SER C 438 SER C 443 1 6 HELIX 33 AD6 GLU C 619 ALA C 623 5 5 HELIX 34 AD7 ASP C 737 GLY C 744 1 8 HELIX 35 AD8 SER C 746 TYR C 756 1 11 HELIX 36 AD9 SER C 758 ALA C 783 1 26 HELIX 37 AE1 SER C 816 ALA C 831 1 16 HELIX 38 AE2 MET C 869 SER C 884 1 16 HELIX 39 AE3 TRP C 886 ALA C 890 5 5 HELIX 40 AE4 PRO C 897 GLY C 908 1 12 HELIX 41 AE5 GLN C 913 ASN C 919 1 7 HELIX 42 AE6 ASN C 919 THR C 941 1 23 HELIX 43 AE7 PRO C 942 ALA C 944 5 3 HELIX 44 AE8 LEU C 945 GLN C 965 1 21 HELIX 45 AE9 LEU C 966 SER C 968 5 3 HELIX 46 AF1 VAL C 976 LEU C 984 1 9 HELIX 47 AF2 ASP C 985 CYS C 1032 1 48 HELIX 48 AF3 PRO C 1140 SER C 1147 1 8 HELIX 49 AF4 GLU F 84 VAL F 88 5 5 HELIX 50 AF5 ASP K 294 LYS K 304 1 11 HELIX 51 AF6 PRO K 337 ALA K 344 1 8 HELIX 52 AF7 ASP K 364 SER K 371 1 8 HELIX 53 AF8 PRO K 384 ASN K 388 5 5 HELIX 54 AF9 ASP K 405 ILE K 410 1 6 HELIX 55 AG1 GLY K 416 TYR K 423 1 8 HELIX 56 AG2 ASP K 737 GLY K 744 1 8 HELIX 57 AG3 SER K 746 LEU K 753 1 8 HELIX 58 AG4 SER K 758 ALA K 783 1 26 HELIX 59 AG5 SER K 816 VAL K 826 1 11 HELIX 60 AG6 GLU K 868 SER K 884 1 17 HELIX 61 AG7 TRP K 886 ALA K 890 5 5 HELIX 62 AG8 PRO K 897 GLY K 908 1 12 HELIX 63 AG9 GLN K 913 ASN K 919 1 7 HELIX 64 AH1 ASN K 919 THR K 941 1 23 HELIX 65 AH2 PRO K 942 ALA K 944 5 3 HELIX 66 AH3 LEU K 945 GLN K 965 1 21 HELIX 67 AH4 LEU K 966 SER K 968 5 3 HELIX 68 AH5 VAL K 976 LEU K 984 1 9 HELIX 69 AH6 ASP K 985 VAL K 1033 1 49 HELIX 70 AH7 PRO K 1140 SER K 1147 1 8 HELIX 71 AH8 GLU L 84 VAL L 88 5 5 SHEET 1 AA1 7 VAL A 36 TYR A 37 0 SHEET 2 AA1 7 ALA A 222 PRO A 230 1 O LEU A 223 N VAL A 36 SHEET 3 AA1 7 TYR A 200 ILE A 210 -1 N PHE A 201 O LEU A 229 SHEET 4 AA1 7 LYS A 187 ILE A 197 -1 N LYS A 187 O ILE A 210 SHEET 5 AA1 7 GLY A 89 SER A 94 -1 N PHE A 92 O PHE A 192 SHEET 6 AA1 7 ALA A 264 TYR A 269 -1 O TYR A 266 N ALA A 93 SHEET 7 AA1 7 PHE A 65 HIS A 66 -1 N PHE A 65 O TYR A 265 SHEET 1 AA2 2 LEU A 84 PRO A 85 0 SHEET 2 AA2 2 ARG A 237 PHE A 238 -1 O PHE A 238 N LEU A 84 SHEET 1 AA3 4 GLY A 103 PHE A 106 0 SHEET 2 AA3 4 LEU A 117 ASN A 121 -1 O LEU A 117 N PHE A 106 SHEET 3 AA3 4 VAL A 126 VAL A 130 -1 O LYS A 129 N LEU A 118 SHEET 4 AA3 4 PHE A 168 SER A 172 -1 O SER A 172 N VAL A 126 SHEET 1 AA4 2 TYR A 144 TYR A 145 0 SHEET 2 AA4 2 TRP A 152 MET A 153 -1 O MET A 153 N TYR A 144 SHEET 1 AA5 5 GLY A 311 ARG A 319 0 SHEET 2 AA5 5 PHE A 592 THR A 599 -1 O VAL A 597 N TYR A 313 SHEET 3 AA5 5 ALA A 609 GLN A 613 -1 O LEU A 611 N SER A 596 SHEET 4 AA5 5 GLY A 648 ILE A 651 -1 O ILE A 651 N VAL A 610 SHEET 5 AA5 5 VAL A 642 THR A 645 -1 N PHE A 643 O LEU A 650 SHEET 1 AA6 7 SER A 325 ARG A 328 0 SHEET 2 AA6 7 VAL A 539 PHE A 543 1 O ASN A 540 N ILE A 326 SHEET 3 AA6 7 LEU A 546 GLU A 554 -1 O GLY A 550 N VAL A 539 SHEET 4 AA6 7 ILE A 584 THR A 588 -1 O ASP A 586 N THR A 553 SHEET 5 AA6 7 THR A 573 ARG A 577 -1 N ASP A 574 O ILE A 587 SHEET 6 AA6 7 GLY A 566 ARG A 567 -1 N GLY A 566 O ASP A 574 SHEET 7 AA6 7 VAL C 42 PHE C 43 1 O VAL C 42 N ARG A 567 SHEET 1 AA7 4 ASN A 354 ILE A 358 0 SHEET 2 AA7 4 VAL A 395 ARG A 403 -1 O VAL A 395 N ILE A 358 SHEET 3 AA7 4 PRO A 507 SER A 514 -1 O VAL A 510 N PHE A 400 SHEET 4 AA7 4 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 1 AA8 2 CYS A 361 VAL A 362 0 SHEET 2 AA8 2 VAL A 524 CYS A 525 1 O CYS A 525 N CYS A 361 SHEET 1 AA9 4 GLU A 654 HIS A 655 0 SHEET 2 AA9 4 SER A 691 THR A 696 1 O ILE A 692 N GLU A 654 SHEET 3 AA9 4 ILE A 670 GLN A 675 -1 N CYS A 671 O TYR A 695 SHEET 4 AA9 4 ILE A 664 GLY A 667 -1 N GLY A 667 O ILE A 670 SHEET 1 AB1 3 ASN A 717 PRO A 728 0 SHEET 2 AB1 3 GLY A1059 GLN A1071 -1 O ALA A1070 N ASN A 717 SHEET 3 AB1 3 TYR A1047 MET A1050 -1 N LEU A1049 O VAL A1065 SHEET 1 AB2 3 ASN A 717 PRO A 728 0 SHEET 2 AB2 3 GLY A1059 GLN A1071 -1 O ALA A1070 N ASN A 717 SHEET 3 AB2 3 PRO A1053 ALA A1056 -1 N GLN A1054 O VAL A1061 SHEET 1 AB3 2 LYS A 733 VAL A 736 0 SHEET 2 AB3 2 LEU A 858 LEU A 861 -1 O THR A 859 N SER A 735 SHEET 1 AB4 2 HIS A1088 PRO A1090 0 SHEET 2 AB4 2 THR A1120 VAL A1122 -1 O PHE A1121 N PHE A1089 SHEET 1 AB5 2 VAL A1094 SER A1097 0 SHEET 2 AB5 2 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 1 AB6 4 ARG B 3 GLN B 6 0 SHEET 2 AB6 4 SER B 17 SER B 25 -1 O LYS B 23 N VAL B 5 SHEET 3 AB6 4 THR B 78 SER B 84 -1 O LEU B 83 N VAL B 18 SHEET 4 AB6 4 THR B 69 ASP B 73 -1 N THR B 71 O TYR B 80 SHEET 1 AB7 2 VAL B 11 LYS B 12 0 SHEET 2 AB7 2 THR B 125 VAL B 126 1 O THR B 125 N LYS B 12 SHEET 1 AB8 2 LEU B 32 HIS B 35 0 SHEET 2 AB8 2 ALA B 97 GLY B 100 -1 O ALA B 97 N HIS B 35 SHEET 1 AB9 2 GLY B 49 ASP B 52 0 SHEET 2 AB9 2 GLU B 57 TYR B 60 -1 O GLU B 57 N ASP B 52 SHEET 1 AC1 7 ALA C 27 SER C 31 0 SHEET 2 AC1 7 SER C 60 PHE C 65 -1 O SER C 60 N SER C 31 SHEET 3 AC1 7 TYR C 265 TYR C 269 -1 O TYR C 265 N PHE C 65 SHEET 4 AC1 7 GLY C 89 SER C 94 -1 N ALA C 93 O TYR C 266 SHEET 5 AC1 7 ARG C 190 LYS C 195 -1 O ARG C 190 N SER C 94 SHEET 6 AC1 7 PHE C 201 LYS C 206 -1 O LYS C 202 N LYS C 195 SHEET 7 AC1 7 GLU C 224 LEU C 229 -1 O LEU C 226 N ILE C 203 SHEET 1 AC2 3 SER C 50 PHE C 55 0 SHEET 2 AC2 3 GLN C 271 TYR C 279 -1 O ARG C 273 N ASP C 53 SHEET 3 AC2 3 ILE C 285 ASP C 290 -1 O ASP C 287 N LYS C 278 SHEET 1 AC3 6 LEU C 84 PRO C 85 0 SHEET 2 AC3 6 ARG C 237 LEU C 241 -1 O PHE C 238 N LEU C 84 SHEET 3 AC3 6 GLY C 103 GLY C 107 -1 N GLY C 107 O ARG C 237 SHEET 4 AC3 6 GLN C 115 ASN C 121 -1 O ILE C 119 N TRP C 104 SHEET 5 AC3 6 VAL C 126 PHE C 135 -1 O VAL C 127 N VAL C 120 SHEET 6 AC3 6 TYR C 160 SER C 172 -1 O SER C 161 N GLN C 134 SHEET 1 AC4 2 LYS C 187 ASN C 188 0 SHEET 2 AC4 2 PRO C 209 ILE C 210 -1 O ILE C 210 N LYS C 187 SHEET 1 AC5 5 GLY C 311 ARG C 319 0 SHEET 2 AC5 5 PHE C 592 THR C 599 -1 O GLY C 593 N PHE C 318 SHEET 3 AC5 5 ALA C 609 GLN C 613 -1 O LEU C 611 N SER C 596 SHEET 4 AC5 5 GLY C 648 ILE C 651 -1 O CYS C 649 N TYR C 612 SHEET 5 AC5 5 VAL C 642 THR C 645 -1 N PHE C 643 O LEU C 650 SHEET 1 AC6 5 SER C 325 ARG C 328 0 SHEET 2 AC6 5 VAL C 539 PHE C 543 1 O ASN C 540 N ILE C 326 SHEET 3 AC6 5 LEU C 546 GLU C 554 -1 O GLY C 550 N VAL C 539 SHEET 4 AC6 5 ILE C 584 THR C 588 -1 O ASP C 586 N THR C 553 SHEET 5 AC6 5 VAL C 576 ARG C 577 -1 N VAL C 576 O LEU C 585 SHEET 1 AC7 5 ASN C 354 ILE C 358 0 SHEET 2 AC7 5 ASN C 394 ARG C 403 -1 O ALA C 397 N LYS C 356 SHEET 3 AC7 5 PRO C 507 GLU C 516 -1 O VAL C 510 N PHE C 400 SHEET 4 AC7 5 GLY C 431 ALA C 435 -1 N ILE C 434 O VAL C 511 SHEET 5 AC7 5 THR C 376 CYS C 379 -1 N THR C 376 O ALA C 435 SHEET 1 AC8 2 CYS C 361 VAL C 362 0 SHEET 2 AC8 2 VAL C 524 CYS C 525 1 O CYS C 525 N CYS C 361 SHEET 1 AC9 2 LEU C 452 TYR C 453 0 SHEET 2 AC9 2 GLN C 493 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AD1 4 GLU C 654 HIS C 655 0 SHEET 2 AD1 4 SER C 691 THR C 696 1 O ILE C 692 N GLU C 654 SHEET 3 AD1 4 ILE C 670 GLN C 675 -1 N CYS C 671 O TYR C 695 SHEET 4 AD1 4 ILE C 664 GLY C 667 -1 N GLY C 667 O ILE C 670 SHEET 1 AD2 3 ILE C 712 PRO C 728 0 SHEET 2 AD2 3 GLY C1059 PHE C1075 -1 O ALA C1070 N ASN C 717 SHEET 3 AD2 3 TYR C1047 MET C1050 -1 N TYR C1047 O TYR C1067 SHEET 1 AD3 3 ILE C 712 PRO C 728 0 SHEET 2 AD3 3 GLY C1059 PHE C1075 -1 O ALA C1070 N ASN C 717 SHEET 3 AD3 3 PRO C1053 ALA C1056 -1 N GLN C1054 O VAL C1061 SHEET 1 AD4 2 LYS C 733 VAL C 736 0 SHEET 2 AD4 2 LEU C 858 LEU C 861 -1 O THR C 859 N SER C 735 SHEET 1 AD5 2 ILE C1081 CYS C1082 0 SHEET 2 AD5 2 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AD6 2 HIS C1088 PRO C1090 0 SHEET 2 AD6 2 THR C1120 VAL C1122 -1 O PHE C1121 N PHE C1089 SHEET 1 AD7 2 VAL C1094 SER C1097 0 SHEET 2 AD7 2 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 1 AD8 2 MET D 4 THR D 5 0 SHEET 2 AD8 2 ARG D 24 SER D 25 -1 O ARG D 24 N THR D 5 SHEET 1 AD9 5 SER D 10 VAL D 13 0 SHEET 2 AD9 5 THR D 107 ILE D 111 1 O GLU D 110 N SER D 11 SHEET 3 AD9 5 VAL D 90 MET D 94 -1 N TYR D 91 O THR D 107 SHEET 4 AD9 5 SER D 39 GLN D 43 -1 N GLN D 43 O VAL D 90 SHEET 5 AD9 5 PRO D 49 ILE D 53 -1 O ARG D 50 N GLN D 42 SHEET 1 AE1 2 SER D 68 ALA D 72 0 SHEET 2 AE1 2 ASP D 75 LYS D 79 -1 O ASP D 75 N ALA D 72 SHEET 1 AE2 5 ALA E 9 LYS E 12 0 SHEET 2 AE2 5 THR E 122 VAL E 126 1 O THR E 125 N GLU E 10 SHEET 3 AE2 5 ALA E 92 TYR E 95 -1 N TYR E 94 O THR E 122 SHEET 4 AE2 5 VAL E 37 GLN E 39 -1 N GLN E 39 O VAL E 93 SHEET 5 AE2 5 LEU E 45 GLU E 46 -1 O GLU E 46 N ARG E 38 SHEET 1 AE3 3 VAL E 18 CYS E 22 0 SHEET 2 AE3 3 THR E 78 LEU E 83 -1 O MET E 81 N VAL E 20 SHEET 3 AE3 3 VAL E 68 ASP E 73 -1 N ASP E 73 O THR E 78 SHEET 1 AE4 3 LEU E 32 ILE E 34 0 SHEET 2 AE4 3 ALA E 97 ALA E 101 -1 O ALA E 99 N SER E 33 SHEET 3 AE4 3 TYR E 112 TRP E 118 -1 O TYR E 113 N GLY E 100 SHEET 1 AE5 2 GLY E 49 ASP E 52 0 SHEET 2 AE5 2 GLU E 57 TYR E 60 -1 O ILE E 59 N GLY E 50 SHEET 1 AE6 2 MET F 4 GLN F 6 0 SHEET 2 AE6 2 CYS F 23 SER F 25 -1 O ARG F 24 N THR F 5 SHEET 1 AE7 5 ASN F 58 ARG F 59 0 SHEET 2 AE7 5 ARG F 50 LYS F 55 -1 N LYS F 55 O ASN F 58 SHEET 3 AE7 5 SER F 39 GLN F 43 -1 N GLN F 42 O ARG F 50 SHEET 4 AE7 5 VAL F 90 MET F 94 -1 O TYR F 92 N LEU F 41 SHEET 5 AE7 5 THR F 107 LYS F 108 -1 O THR F 107 N TYR F 91 SHEET 1 AE8 2 SER F 68 ALA F 72 0 SHEET 2 AE8 2 ASP F 75 LYS F 79 -1 O LYS F 79 N SER F 68 SHEET 1 AE9 2 ALA H 9 LYS H 12 0 SHEET 2 AE9 2 THR H 123 VAL H 126 1 O THR H 125 N GLU H 10 SHEET 1 AF1 2 VAL H 18 VAL H 20 0 SHEET 2 AF1 2 MET H 81 LEU H 83 -1 O MET H 81 N VAL H 20 SHEET 1 AF2 4 THR H 58 TYR H 60 0 SHEET 2 AF2 4 GLY H 44 PHE H 51 -1 N GLY H 50 O ILE H 59 SHEET 3 AF2 4 SER H 33 ALA H 40 -1 N TRP H 36 O MET H 48 SHEET 4 AF2 4 THR H 98 ALA H 99 -1 O ALA H 99 N SER H 33 SHEET 1 AF3 6 VAL K 36 TYR K 37 0 SHEET 2 AF3 6 ALA K 222 LEU K 229 1 O LEU K 223 N VAL K 36 SHEET 3 AF3 6 TYR K 200 LYS K 206 -1 N PHE K 201 O LEU K 229 SHEET 4 AF3 6 ARG K 190 ILE K 197 -1 N LYS K 195 O LYS K 202 SHEET 5 AF3 6 GLY K 89 SER K 94 -1 N VAL K 90 O PHE K 194 SHEET 6 AF3 6 TYR K 265 TYR K 269 -1 O TYR K 266 N ALA K 93 SHEET 1 AF4 3 HIS K 49 PHE K 55 0 SHEET 2 AF4 3 GLN K 271 TYR K 279 -1 O ARG K 273 N ASP K 53 SHEET 3 AF4 3 ILE K 285 ASP K 290 -1 O VAL K 289 N LEU K 276 SHEET 1 AF5 6 LEU K 84 PRO K 85 0 SHEET 2 AF5 6 ARG K 237 PHE K 238 -1 O PHE K 238 N LEU K 84 SHEET 3 AF5 6 GLY K 103 GLY K 107 -1 O GLY K 107 N ARG K 237 SHEET 4 AF5 6 SER K 116 ASN K 121 -1 O ILE K 119 N TRP K 104 SHEET 5 AF5 6 VAL K 126 PHE K 135 -1 O VAL K 127 N VAL K 120 SHEET 6 AF5 6 TYR K 160 SER K 172 -1 O TYR K 170 N ILE K 128 SHEET 1 AF6 2 PHE K 186 LYS K 187 0 SHEET 2 AF6 2 ILE K 210 ASN K 211 -1 O ILE K 210 N LYS K 187 SHEET 1 AF7 5 GLY K 311 ARG K 319 0 SHEET 2 AF7 5 PHE K 592 THR K 599 -1 O GLY K 593 N PHE K 318 SHEET 3 AF7 5 ALA K 609 GLN K 613 -1 O LEU K 611 N SER K 596 SHEET 4 AF7 5 GLY K 648 ILE K 651 -1 O ILE K 651 N VAL K 610 SHEET 5 AF7 5 PHE K 643 THR K 645 -1 N PHE K 643 O LEU K 650 SHEET 1 AF8 4 LYS K 356 ILE K 358 0 SHEET 2 AF8 4 ASN K 394 ILE K 402 -1 O ALA K 397 N LYS K 356 SHEET 3 AF8 4 TYR K 508 GLU K 516 -1 O VAL K 510 N PHE K 400 SHEET 4 AF8 4 GLY K 431 TRP K 436 -1 N ILE K 434 O VAL K 511 SHEET 1 AF9 4 VAL K 539 PHE K 543 0 SHEET 2 AF9 4 LEU K 546 GLU K 554 -1 O GLY K 550 N VAL K 539 SHEET 3 AF9 4 ILE K 584 THR K 588 -1 O ASP K 586 N THR K 553 SHEET 4 AF9 4 VAL K 576 ARG K 577 -1 N VAL K 576 O LEU K 585 SHEET 1 AG1 4 GLU K 654 HIS K 655 0 SHEET 2 AG1 4 SER K 691 THR K 696 1 O ILE K 692 N GLU K 654 SHEET 3 AG1 4 ILE K 670 GLN K 675 -1 N CYS K 671 O TYR K 695 SHEET 4 AG1 4 ILE K 664 GLY K 667 -1 N GLY K 667 O ILE K 670 SHEET 1 AG2 2 ILE K 712 PRO K 715 0 SHEET 2 AG2 2 GLU K1072 PHE K1075 -1 O PHE K1075 N ILE K 712 SHEET 1 AG3 3 PHE K 718 PRO K 728 0 SHEET 2 AG3 3 GLY K1059 PRO K1069 -1 O HIS K1064 N THR K 723 SHEET 3 AG3 3 TYR K1047 MET K1050 -1 N TYR K1047 O TYR K1067 SHEET 1 AG4 3 PHE K 718 PRO K 728 0 SHEET 2 AG4 3 GLY K1059 PRO K1069 -1 O HIS K1064 N THR K 723 SHEET 3 AG4 3 PRO K1053 ALA K1056 -1 N GLN K1054 O VAL K1061 SHEET 1 AG5 2 LYS K 733 VAL K 736 0 SHEET 2 AG5 2 LEU K 858 LEU K 861 -1 O THR K 859 N SER K 735 SHEET 1 AG6 2 ILE K1081 CYS K1082 0 SHEET 2 AG6 2 VAL K1133 ASN K1134 1 O VAL K1133 N CYS K1082 SHEET 1 AG7 2 LYS K1086 PRO K1090 0 SHEET 2 AG7 2 THR K1120 ASN K1125 -1 O PHE K1121 N PHE K1089 SHEET 1 AG8 2 VAL K1094 SER K1097 0 SHEET 2 AG8 2 TRP K1102 THR K1105 -1 O PHE K1103 N VAL K1096 SHEET 1 AG9 2 MET L 4 GLN L 6 0 SHEET 2 AG9 2 CYS L 23 SER L 25 -1 O ARG L 24 N THR L 5 SHEET 1 AH1 4 PRO L 49 ILE L 53 0 SHEET 2 AH1 4 LEU L 38 GLN L 43 -1 N GLN L 42 O ARG L 50 SHEET 3 AH1 4 VAL L 90 GLN L 95 -1 O MET L 94 N SER L 39 SHEET 4 AH1 4 THR L 107 LYS L 108 -1 O THR L 107 N TYR L 91 SHEET 1 AH2 2 SER L 68 GLY L 71 0 SHEET 2 AH2 2 PHE L 76 LYS L 79 -1 O LYS L 79 N SER L 68 SSBOND 1 CYS A 15 CYS A 136 1555 1555 2.03 SSBOND 2 CYS A 131 CYS A 166 1555 1555 2.04 SSBOND 3 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 4 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 5 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 6 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 7 CYS A 538 CYS A 590 1555 1555 2.03 SSBOND 8 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 9 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 10 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 11 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 12 CYS A 1082 CYS A 1126 1555 1555 2.07 SSBOND 13 CYS B 22 CYS B 96 1555 1555 2.03 SSBOND 14 CYS C 15 CYS C 136 1555 1555 2.04 SSBOND 15 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 16 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 17 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 18 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 19 CYS C 538 CYS C 590 1555 1555 2.03 SSBOND 20 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 21 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 22 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 23 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 24 CYS C 1032 CYS C 1043 1555 1555 2.03 SSBOND 25 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 26 CYS D 23 CYS D 93 1555 1555 2.03 SSBOND 27 CYS E 22 CYS E 96 1555 1555 2.03 SSBOND 28 CYS F 23 CYS F 93 1555 1555 2.03 SSBOND 29 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 30 CYS K 15 CYS K 136 1555 1555 2.03 SSBOND 31 CYS K 291 CYS K 301 1555 1555 2.03 SSBOND 32 CYS K 336 CYS K 361 1555 1555 2.03 SSBOND 33 CYS K 379 CYS K 432 1555 1555 2.03 SSBOND 34 CYS K 391 CYS K 525 1555 1555 2.03 SSBOND 35 CYS K 538 CYS K 590 1555 1555 2.03 SSBOND 36 CYS K 617 CYS K 649 1555 1555 2.03 SSBOND 37 CYS K 662 CYS K 671 1555 1555 2.03 SSBOND 38 CYS K 738 CYS K 760 1555 1555 2.03 SSBOND 39 CYS K 743 CYS K 749 1555 1555 2.03 SSBOND 40 CYS K 1032 CYS K 1043 1555 1555 2.02 SSBOND 41 CYS K 1082 CYS K 1126 1555 1555 2.03 SSBOND 42 CYS L 23 CYS L 93 1555 1555 2.03 LINK ND2 ASN A 61 C1 NAG A1305 1555 1555 1.44 LINK ND2 ASN A 282 C1 NAG A1306 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG A1307 1555 1555 1.45 LINK ND2 ASN A 616 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 657 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 709 C1 NAG A1308 1555 1555 1.43 LINK ND2 ASN A 717 C1 NAG A1309 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG A1310 1555 1555 1.44 LINK ND2 ASN A1074 C1 NAG A1311 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A1134 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN C 282 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG C1306 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG C1304 1555 1555 1.44 LINK ND2 ASN C 657 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 709 C1 NAG C1307 1555 1555 1.44 LINK ND2 ASN C 717 C1 NAG C1308 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG C1309 1555 1555 1.44 LINK ND2 ASN C1074 C1 NAG C1310 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG C1301 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN K 61 C1 NAG K1303 1555 1555 1.44 LINK ND2 ASN K 282 C1 NAG K1310 1555 1555 1.44 LINK ND2 ASN K 331 C1 NAG K1311 1555 1555 1.44 LINK ND2 ASN K 616 C1 NAG K1309 1555 1555 1.44 LINK ND2 ASN K 657 C1 NAG K1302 1555 1555 1.44 LINK ND2 ASN K 709 C1 NAG K1304 1555 1555 1.44 LINK ND2 ASN K 717 C1 NAG K1305 1555 1555 1.44 LINK ND2 ASN K 801 C1 NAG K1306 1555 1555 1.44 LINK ND2 ASN K1074 C1 NAG K1301 1555 1555 1.44 LINK ND2 ASN K1098 C1 NAG K1307 1555 1555 1.44 LINK ND2 ASN K1134 C1 NAG K1308 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000