HEADER IMMUNE SYSTEM 18-DEC-24 9ML1 TITLE D24.1M01 FAB BOUND TO HPV16 L1 PENTAMER COMPND MOL_ID: 1; COMPND 2 MOLECULE: MAJOR CAPSID PROTEIN L1; COMPND 3 CHAIN: A, B, C, D, E; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: D24.1M01 HEAVY CHAIN; COMPND 7 CHAIN: H, M, O, Q, S; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: D24.1M01 LIGHT CHAIN; COMPND 11 CHAIN: L, N, P, R, T; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN PAPILLOMAVIRUS 16; SOURCE 3 ORGANISM_TAXID: 333760; SOURCE 4 GENE: L1; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 7 EXPRESSION_SYSTEM_STRAIN: PLYSS; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM_CELL_LINE: HEK 293E; SOURCE 16 MOL_ID: 3; SOURCE 17 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 18 ORGANISM_COMMON: HUMAN; SOURCE 19 ORGANISM_TAXID: 9606; SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 21 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 23 EXPRESSION_SYSTEM_CELL_LINE: HEK 293E KEYWDS HPV, ANTIBODY, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR N.K.HURLBURT,S.SINGH,J.V.RODARTE,M.PANCERA REVDAT 1 20-AUG-25 9ML1 0 JRNL AUTH J.J.CARTER,N.K.HURLBURT JRNL TITL HPV16 NEUTRALIZING MONOCLONAL ANTIBODIES SHOW EVIDENCE FOR JRNL TITL 2 COMMON DEVELOPMENTAL PATHWAYS AND PUBLIC EPITOPES JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.00 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.000 REMARK 3 NUMBER OF PARTICLES : 188743 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9ML1 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 24-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1000290750. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HPV16 L1 PENTAMER BOUND TO FIVE REMARK 245 D24.1M01 FABS REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON III (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2200.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 96000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 15-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 15-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, H, L, M, N, O, REMARK 350 AND CHAINS: P, Q, R, S, T REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 GLY A 446 REMARK 465 GLY A 447 REMARK 465 SER A 448 REMARK 465 GLY A 449 REMARK 465 ALA A 450 REMARK 465 GLU A 451 REMARK 465 GLY A 487 REMARK 465 LEU A 488 REMARK 465 GLY B 446 REMARK 465 GLY B 447 REMARK 465 SER B 448 REMARK 465 GLY B 449 REMARK 465 ALA B 450 REMARK 465 GLU B 451 REMARK 465 GLY B 487 REMARK 465 LEU B 488 REMARK 465 GLY C 446 REMARK 465 GLY C 447 REMARK 465 SER C 448 REMARK 465 GLY C 449 REMARK 465 ALA C 450 REMARK 465 GLU C 451 REMARK 465 GLY C 487 REMARK 465 LEU C 488 REMARK 465 GLY D 446 REMARK 465 GLY D 447 REMARK 465 SER D 448 REMARK 465 GLY D 449 REMARK 465 ALA D 450 REMARK 465 GLU D 451 REMARK 465 GLY D 487 REMARK 465 LEU D 488 REMARK 465 GLY E 446 REMARK 465 GLY E 447 REMARK 465 SER E 448 REMARK 465 GLY E 449 REMARK 465 ALA E 450 REMARK 465 GLU E 451 REMARK 465 GLY E 487 REMARK 465 LEU E 488 REMARK 465 SER H 113 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 THR H 219 REMARK 465 HIS H 220 REMARK 465 HIS H 221 REMARK 465 HIS H 222 REMARK 465 HIS H 223 REMARK 465 HIS H 224 REMARK 465 HIS H 225 REMARK 465 GLN L 1 REMARK 465 GLN L 108 REMARK 465 PRO L 109 REMARK 465 LYS L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 THR L 116 REMARK 465 LEU L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 SER L 122 REMARK 465 GLU L 123 REMARK 465 GLU L 124 REMARK 465 LEU L 125 REMARK 465 GLN L 126 REMARK 465 ALA L 127 REMARK 465 ASN L 128 REMARK 465 LYS L 129 REMARK 465 ALA L 130 REMARK 465 THR L 131 REMARK 465 LEU L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 ILE L 136 REMARK 465 SER L 137 REMARK 465 ASP L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 GLY L 142 REMARK 465 ALA L 143 REMARK 465 VAL L 144 REMARK 465 THR L 145 REMARK 465 VAL L 146 REMARK 465 ALA L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 ALA L 150 REMARK 465 ASP L 151 REMARK 465 SER L 152 REMARK 465 SER L 153 REMARK 465 PRO L 154 REMARK 465 VAL L 155 REMARK 465 LYS L 156 REMARK 465 ALA L 157 REMARK 465 GLY L 158 REMARK 465 VAL L 159 REMARK 465 GLU L 160 REMARK 465 THR L 161 REMARK 465 THR L 162 REMARK 465 THR L 163 REMARK 465 PRO L 164 REMARK 465 SER L 165 REMARK 465 LYS L 166 REMARK 465 GLN L 167 REMARK 465 SER L 168 REMARK 465 ASN L 169 REMARK 465 ASN L 170 REMARK 465 LYS L 171 REMARK 465 TYR L 172 REMARK 465 ALA L 173 REMARK 465 ALA L 174 REMARK 465 SER L 175 REMARK 465 SER L 176 REMARK 465 TYR L 177 REMARK 465 LEU L 178 REMARK 465 SER L 179 REMARK 465 LEU L 180 REMARK 465 THR L 181 REMARK 465 PRO L 182 REMARK 465 GLU L 183 REMARK 465 GLN L 184 REMARK 465 TRP L 185 REMARK 465 LYS L 186 REMARK 465 SER L 187 REMARK 465 HIS L 188 REMARK 465 ARG L 189 REMARK 465 SER L 190 REMARK 465 TYR L 191 REMARK 465 SER L 192 REMARK 465 CYS L 193 REMARK 465 GLN L 194 REMARK 465 VAL L 195 REMARK 465 THR L 196 REMARK 465 HIS L 197 REMARK 465 GLU L 198 REMARK 465 GLY L 199 REMARK 465 SER L 200 REMARK 465 THR L 201 REMARK 465 VAL L 202 REMARK 465 GLU L 203 REMARK 465 LYS L 204 REMARK 465 THR L 205 REMARK 465 VAL L 206 REMARK 465 ALA L 207 REMARK 465 PRO L 208 REMARK 465 THR L 209 REMARK 465 GLU L 210 REMARK 465 CYS L 211 REMARK 465 SER L 212 REMARK 465 SER M 113 REMARK 465 ALA M 114 REMARK 465 SER M 115 REMARK 465 THR M 116 REMARK 465 LYS M 117 REMARK 465 GLY M 118 REMARK 465 PRO M 119 REMARK 465 SER M 120 REMARK 465 VAL M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 LEU M 124 REMARK 465 ALA M 125 REMARK 465 PRO M 126 REMARK 465 SER M 127 REMARK 465 SER M 128 REMARK 465 LYS M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 SER M 132 REMARK 465 GLY M 133 REMARK 465 GLY M 134 REMARK 465 THR M 135 REMARK 465 ALA M 136 REMARK 465 ALA M 137 REMARK 465 LEU M 138 REMARK 465 GLY M 139 REMARK 465 CYS M 140 REMARK 465 LEU M 141 REMARK 465 VAL M 142 REMARK 465 LYS M 143 REMARK 465 ASP M 144 REMARK 465 TYR M 145 REMARK 465 PHE M 146 REMARK 465 PRO M 147 REMARK 465 GLU M 148 REMARK 465 PRO M 149 REMARK 465 VAL M 150 REMARK 465 THR M 151 REMARK 465 VAL M 152 REMARK 465 SER M 153 REMARK 465 TRP M 154 REMARK 465 ASN M 155 REMARK 465 SER M 156 REMARK 465 GLY M 157 REMARK 465 ALA M 158 REMARK 465 LEU M 159 REMARK 465 THR M 160 REMARK 465 SER M 161 REMARK 465 GLY M 162 REMARK 465 VAL M 163 REMARK 465 HIS M 164 REMARK 465 THR M 165 REMARK 465 PHE M 166 REMARK 465 PRO M 167 REMARK 465 ALA M 168 REMARK 465 VAL M 169 REMARK 465 LEU M 170 REMARK 465 GLN M 171 REMARK 465 SER M 172 REMARK 465 SER M 173 REMARK 465 GLY M 174 REMARK 465 LEU M 175 REMARK 465 TYR M 176 REMARK 465 SER M 177 REMARK 465 LEU M 178 REMARK 465 SER M 179 REMARK 465 SER M 180 REMARK 465 VAL M 181 REMARK 465 VAL M 182 REMARK 465 THR M 183 REMARK 465 VAL M 184 REMARK 465 PRO M 185 REMARK 465 SER M 186 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 LEU M 189 REMARK 465 GLY M 190 REMARK 465 THR M 191 REMARK 465 GLN M 192 REMARK 465 THR M 193 REMARK 465 TYR M 194 REMARK 465 ILE M 195 REMARK 465 CYS M 196 REMARK 465 ASN M 197 REMARK 465 VAL M 198 REMARK 465 ASN M 199 REMARK 465 HIS M 200 REMARK 465 LYS M 201 REMARK 465 PRO M 202 REMARK 465 SER M 203 REMARK 465 ASN M 204 REMARK 465 THR M 205 REMARK 465 LYS M 206 REMARK 465 VAL M 207 REMARK 465 ASP M 208 REMARK 465 LYS M 209 REMARK 465 ARG M 210 REMARK 465 VAL M 211 REMARK 465 GLU M 212 REMARK 465 PRO M 213 REMARK 465 LYS M 214 REMARK 465 SER M 215 REMARK 465 CYS M 216 REMARK 465 ASP M 217 REMARK 465 LYS M 218 REMARK 465 THR M 219 REMARK 465 HIS M 220 REMARK 465 HIS M 221 REMARK 465 HIS M 222 REMARK 465 HIS M 223 REMARK 465 HIS M 224 REMARK 465 HIS M 225 REMARK 465 GLN N 1 REMARK 465 GLN N 108 REMARK 465 PRO N 109 REMARK 465 LYS N 110 REMARK 465 ALA N 111 REMARK 465 ALA N 112 REMARK 465 PRO N 113 REMARK 465 SER N 114 REMARK 465 VAL N 115 REMARK 465 THR N 116 REMARK 465 LEU N 117 REMARK 465 PHE N 118 REMARK 465 PRO N 119 REMARK 465 PRO N 120 REMARK 465 SER N 121 REMARK 465 SER N 122 REMARK 465 GLU N 123 REMARK 465 GLU N 124 REMARK 465 LEU N 125 REMARK 465 GLN N 126 REMARK 465 ALA N 127 REMARK 465 ASN N 128 REMARK 465 LYS N 129 REMARK 465 ALA N 130 REMARK 465 THR N 131 REMARK 465 LEU N 132 REMARK 465 VAL N 133 REMARK 465 CYS N 134 REMARK 465 LEU N 135 REMARK 465 ILE N 136 REMARK 465 SER N 137 REMARK 465 ASP N 138 REMARK 465 PHE N 139 REMARK 465 TYR N 140 REMARK 465 PRO N 141 REMARK 465 GLY N 142 REMARK 465 ALA N 143 REMARK 465 VAL N 144 REMARK 465 THR N 145 REMARK 465 VAL N 146 REMARK 465 ALA N 147 REMARK 465 TRP N 148 REMARK 465 LYS N 149 REMARK 465 ALA N 150 REMARK 465 ASP N 151 REMARK 465 SER N 152 REMARK 465 SER N 153 REMARK 465 PRO N 154 REMARK 465 VAL N 155 REMARK 465 LYS N 156 REMARK 465 ALA N 157 REMARK 465 GLY N 158 REMARK 465 VAL N 159 REMARK 465 GLU N 160 REMARK 465 THR N 161 REMARK 465 THR N 162 REMARK 465 THR N 163 REMARK 465 PRO N 164 REMARK 465 SER N 165 REMARK 465 LYS N 166 REMARK 465 GLN N 167 REMARK 465 SER N 168 REMARK 465 ASN N 169 REMARK 465 ASN N 170 REMARK 465 LYS N 171 REMARK 465 TYR N 172 REMARK 465 ALA N 173 REMARK 465 ALA N 174 REMARK 465 SER N 175 REMARK 465 SER N 176 REMARK 465 TYR N 177 REMARK 465 LEU N 178 REMARK 465 SER N 179 REMARK 465 LEU N 180 REMARK 465 THR N 181 REMARK 465 PRO N 182 REMARK 465 GLU N 183 REMARK 465 GLN N 184 REMARK 465 TRP N 185 REMARK 465 LYS N 186 REMARK 465 SER N 187 REMARK 465 HIS N 188 REMARK 465 ARG N 189 REMARK 465 SER N 190 REMARK 465 TYR N 191 REMARK 465 SER N 192 REMARK 465 CYS N 193 REMARK 465 GLN N 194 REMARK 465 VAL N 195 REMARK 465 THR N 196 REMARK 465 HIS N 197 REMARK 465 GLU N 198 REMARK 465 GLY N 199 REMARK 465 SER N 200 REMARK 465 THR N 201 REMARK 465 VAL N 202 REMARK 465 GLU N 203 REMARK 465 LYS N 204 REMARK 465 THR N 205 REMARK 465 VAL N 206 REMARK 465 ALA N 207 REMARK 465 PRO N 208 REMARK 465 THR N 209 REMARK 465 GLU N 210 REMARK 465 CYS N 211 REMARK 465 SER N 212 REMARK 465 SER O 113 REMARK 465 ALA O 114 REMARK 465 SER O 115 REMARK 465 THR O 116 REMARK 465 LYS O 117 REMARK 465 GLY O 118 REMARK 465 PRO O 119 REMARK 465 SER O 120 REMARK 465 VAL O 121 REMARK 465 PHE O 122 REMARK 465 PRO O 123 REMARK 465 LEU O 124 REMARK 465 ALA O 125 REMARK 465 PRO O 126 REMARK 465 SER O 127 REMARK 465 SER O 128 REMARK 465 LYS O 129 REMARK 465 SER O 130 REMARK 465 THR O 131 REMARK 465 SER O 132 REMARK 465 GLY O 133 REMARK 465 GLY O 134 REMARK 465 THR O 135 REMARK 465 ALA O 136 REMARK 465 ALA O 137 REMARK 465 LEU O 138 REMARK 465 GLY O 139 REMARK 465 CYS O 140 REMARK 465 LEU O 141 REMARK 465 VAL O 142 REMARK 465 LYS O 143 REMARK 465 ASP O 144 REMARK 465 TYR O 145 REMARK 465 PHE O 146 REMARK 465 PRO O 147 REMARK 465 GLU O 148 REMARK 465 PRO O 149 REMARK 465 VAL O 150 REMARK 465 THR O 151 REMARK 465 VAL O 152 REMARK 465 SER O 153 REMARK 465 TRP O 154 REMARK 465 ASN O 155 REMARK 465 SER O 156 REMARK 465 GLY O 157 REMARK 465 ALA O 158 REMARK 465 LEU O 159 REMARK 465 THR O 160 REMARK 465 SER O 161 REMARK 465 GLY O 162 REMARK 465 VAL O 163 REMARK 465 HIS O 164 REMARK 465 THR O 165 REMARK 465 PHE O 166 REMARK 465 PRO O 167 REMARK 465 ALA O 168 REMARK 465 VAL O 169 REMARK 465 LEU O 170 REMARK 465 GLN O 171 REMARK 465 SER O 172 REMARK 465 SER O 173 REMARK 465 GLY O 174 REMARK 465 LEU O 175 REMARK 465 TYR O 176 REMARK 465 SER O 177 REMARK 465 LEU O 178 REMARK 465 SER O 179 REMARK 465 SER O 180 REMARK 465 VAL O 181 REMARK 465 VAL O 182 REMARK 465 THR O 183 REMARK 465 VAL O 184 REMARK 465 PRO O 185 REMARK 465 SER O 186 REMARK 465 SER O 187 REMARK 465 SER O 188 REMARK 465 LEU O 189 REMARK 465 GLY O 190 REMARK 465 THR O 191 REMARK 465 GLN O 192 REMARK 465 THR O 193 REMARK 465 TYR O 194 REMARK 465 ILE O 195 REMARK 465 CYS O 196 REMARK 465 ASN O 197 REMARK 465 VAL O 198 REMARK 465 ASN O 199 REMARK 465 HIS O 200 REMARK 465 LYS O 201 REMARK 465 PRO O 202 REMARK 465 SER O 203 REMARK 465 ASN O 204 REMARK 465 THR O 205 REMARK 465 LYS O 206 REMARK 465 VAL O 207 REMARK 465 ASP O 208 REMARK 465 LYS O 209 REMARK 465 ARG O 210 REMARK 465 VAL O 211 REMARK 465 GLU O 212 REMARK 465 PRO O 213 REMARK 465 LYS O 214 REMARK 465 SER O 215 REMARK 465 CYS O 216 REMARK 465 ASP O 217 REMARK 465 LYS O 218 REMARK 465 THR O 219 REMARK 465 HIS O 220 REMARK 465 HIS O 221 REMARK 465 HIS O 222 REMARK 465 HIS O 223 REMARK 465 HIS O 224 REMARK 465 HIS O 225 REMARK 465 GLN P 1 REMARK 465 GLN P 108 REMARK 465 PRO P 109 REMARK 465 LYS P 110 REMARK 465 ALA P 111 REMARK 465 ALA P 112 REMARK 465 PRO P 113 REMARK 465 SER P 114 REMARK 465 VAL P 115 REMARK 465 THR P 116 REMARK 465 LEU P 117 REMARK 465 PHE P 118 REMARK 465 PRO P 119 REMARK 465 PRO P 120 REMARK 465 SER P 121 REMARK 465 SER P 122 REMARK 465 GLU P 123 REMARK 465 GLU P 124 REMARK 465 LEU P 125 REMARK 465 GLN P 126 REMARK 465 ALA P 127 REMARK 465 ASN P 128 REMARK 465 LYS P 129 REMARK 465 ALA P 130 REMARK 465 THR P 131 REMARK 465 LEU P 132 REMARK 465 VAL P 133 REMARK 465 CYS P 134 REMARK 465 LEU P 135 REMARK 465 ILE P 136 REMARK 465 SER P 137 REMARK 465 ASP P 138 REMARK 465 PHE P 139 REMARK 465 TYR P 140 REMARK 465 PRO P 141 REMARK 465 GLY P 142 REMARK 465 ALA P 143 REMARK 465 VAL P 144 REMARK 465 THR P 145 REMARK 465 VAL P 146 REMARK 465 ALA P 147 REMARK 465 TRP P 148 REMARK 465 LYS P 149 REMARK 465 ALA P 150 REMARK 465 ASP P 151 REMARK 465 SER P 152 REMARK 465 SER P 153 REMARK 465 PRO P 154 REMARK 465 VAL P 155 REMARK 465 LYS P 156 REMARK 465 ALA P 157 REMARK 465 GLY P 158 REMARK 465 VAL P 159 REMARK 465 GLU P 160 REMARK 465 THR P 161 REMARK 465 THR P 162 REMARK 465 THR P 163 REMARK 465 PRO P 164 REMARK 465 SER P 165 REMARK 465 LYS P 166 REMARK 465 GLN P 167 REMARK 465 SER P 168 REMARK 465 ASN P 169 REMARK 465 ASN P 170 REMARK 465 LYS P 171 REMARK 465 TYR P 172 REMARK 465 ALA P 173 REMARK 465 ALA P 174 REMARK 465 SER P 175 REMARK 465 SER P 176 REMARK 465 TYR P 177 REMARK 465 LEU P 178 REMARK 465 SER P 179 REMARK 465 LEU P 180 REMARK 465 THR P 181 REMARK 465 PRO P 182 REMARK 465 GLU P 183 REMARK 465 GLN P 184 REMARK 465 TRP P 185 REMARK 465 LYS P 186 REMARK 465 SER P 187 REMARK 465 HIS P 188 REMARK 465 ARG P 189 REMARK 465 SER P 190 REMARK 465 TYR P 191 REMARK 465 SER P 192 REMARK 465 CYS P 193 REMARK 465 GLN P 194 REMARK 465 VAL P 195 REMARK 465 THR P 196 REMARK 465 HIS P 197 REMARK 465 GLU P 198 REMARK 465 GLY P 199 REMARK 465 SER P 200 REMARK 465 THR P 201 REMARK 465 VAL P 202 REMARK 465 GLU P 203 REMARK 465 LYS P 204 REMARK 465 THR P 205 REMARK 465 VAL P 206 REMARK 465 ALA P 207 REMARK 465 PRO P 208 REMARK 465 THR P 209 REMARK 465 GLU P 210 REMARK 465 CYS P 211 REMARK 465 SER P 212 REMARK 465 SER Q 113 REMARK 465 ALA Q 114 REMARK 465 SER Q 115 REMARK 465 THR Q 116 REMARK 465 LYS Q 117 REMARK 465 GLY Q 118 REMARK 465 PRO Q 119 REMARK 465 SER Q 120 REMARK 465 VAL Q 121 REMARK 465 PHE Q 122 REMARK 465 PRO Q 123 REMARK 465 LEU Q 124 REMARK 465 ALA Q 125 REMARK 465 PRO Q 126 REMARK 465 SER Q 127 REMARK 465 SER Q 128 REMARK 465 LYS Q 129 REMARK 465 SER Q 130 REMARK 465 THR Q 131 REMARK 465 SER Q 132 REMARK 465 GLY Q 133 REMARK 465 GLY Q 134 REMARK 465 THR Q 135 REMARK 465 ALA Q 136 REMARK 465 ALA Q 137 REMARK 465 LEU Q 138 REMARK 465 GLY Q 139 REMARK 465 CYS Q 140 REMARK 465 LEU Q 141 REMARK 465 VAL Q 142 REMARK 465 LYS Q 143 REMARK 465 ASP Q 144 REMARK 465 TYR Q 145 REMARK 465 PHE Q 146 REMARK 465 PRO Q 147 REMARK 465 GLU Q 148 REMARK 465 PRO Q 149 REMARK 465 VAL Q 150 REMARK 465 THR Q 151 REMARK 465 VAL Q 152 REMARK 465 SER Q 153 REMARK 465 TRP Q 154 REMARK 465 ASN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ALA Q 158 REMARK 465 LEU Q 159 REMARK 465 THR Q 160 REMARK 465 SER Q 161 REMARK 465 GLY Q 162 REMARK 465 VAL Q 163 REMARK 465 HIS Q 164 REMARK 465 THR Q 165 REMARK 465 PHE Q 166 REMARK 465 PRO Q 167 REMARK 465 ALA Q 168 REMARK 465 VAL Q 169 REMARK 465 LEU Q 170 REMARK 465 GLN Q 171 REMARK 465 SER Q 172 REMARK 465 SER Q 173 REMARK 465 GLY Q 174 REMARK 465 LEU Q 175 REMARK 465 TYR Q 176 REMARK 465 SER Q 177 REMARK 465 LEU Q 178 REMARK 465 SER Q 179 REMARK 465 SER Q 180 REMARK 465 VAL Q 181 REMARK 465 VAL Q 182 REMARK 465 THR Q 183 REMARK 465 VAL Q 184 REMARK 465 PRO Q 185 REMARK 465 SER Q 186 REMARK 465 SER Q 187 REMARK 465 SER Q 188 REMARK 465 LEU Q 189 REMARK 465 GLY Q 190 REMARK 465 THR Q 191 REMARK 465 GLN Q 192 REMARK 465 THR Q 193 REMARK 465 TYR Q 194 REMARK 465 ILE Q 195 REMARK 465 CYS Q 196 REMARK 465 ASN Q 197 REMARK 465 VAL Q 198 REMARK 465 ASN Q 199 REMARK 465 HIS Q 200 REMARK 465 LYS Q 201 REMARK 465 PRO Q 202 REMARK 465 SER Q 203 REMARK 465 ASN Q 204 REMARK 465 THR Q 205 REMARK 465 LYS Q 206 REMARK 465 VAL Q 207 REMARK 465 ASP Q 208 REMARK 465 LYS Q 209 REMARK 465 ARG Q 210 REMARK 465 VAL Q 211 REMARK 465 GLU Q 212 REMARK 465 PRO Q 213 REMARK 465 LYS Q 214 REMARK 465 SER Q 215 REMARK 465 CYS Q 216 REMARK 465 ASP Q 217 REMARK 465 LYS Q 218 REMARK 465 THR Q 219 REMARK 465 HIS Q 220 REMARK 465 HIS Q 221 REMARK 465 HIS Q 222 REMARK 465 HIS Q 223 REMARK 465 HIS Q 224 REMARK 465 HIS Q 225 REMARK 465 GLN R 1 REMARK 465 GLN R 108 REMARK 465 PRO R 109 REMARK 465 LYS R 110 REMARK 465 ALA R 111 REMARK 465 ALA R 112 REMARK 465 PRO R 113 REMARK 465 SER R 114 REMARK 465 VAL R 115 REMARK 465 THR R 116 REMARK 465 LEU R 117 REMARK 465 PHE R 118 REMARK 465 PRO R 119 REMARK 465 PRO R 120 REMARK 465 SER R 121 REMARK 465 SER R 122 REMARK 465 GLU R 123 REMARK 465 GLU R 124 REMARK 465 LEU R 125 REMARK 465 GLN R 126 REMARK 465 ALA R 127 REMARK 465 ASN R 128 REMARK 465 LYS R 129 REMARK 465 ALA R 130 REMARK 465 THR R 131 REMARK 465 LEU R 132 REMARK 465 VAL R 133 REMARK 465 CYS R 134 REMARK 465 LEU R 135 REMARK 465 ILE R 136 REMARK 465 SER R 137 REMARK 465 ASP R 138 REMARK 465 PHE R 139 REMARK 465 TYR R 140 REMARK 465 PRO R 141 REMARK 465 GLY R 142 REMARK 465 ALA R 143 REMARK 465 VAL R 144 REMARK 465 THR R 145 REMARK 465 VAL R 146 REMARK 465 ALA R 147 REMARK 465 TRP R 148 REMARK 465 LYS R 149 REMARK 465 ALA R 150 REMARK 465 ASP R 151 REMARK 465 SER R 152 REMARK 465 SER R 153 REMARK 465 PRO R 154 REMARK 465 VAL R 155 REMARK 465 LYS R 156 REMARK 465 ALA R 157 REMARK 465 GLY R 158 REMARK 465 VAL R 159 REMARK 465 GLU R 160 REMARK 465 THR R 161 REMARK 465 THR R 162 REMARK 465 THR R 163 REMARK 465 PRO R 164 REMARK 465 SER R 165 REMARK 465 LYS R 166 REMARK 465 GLN R 167 REMARK 465 SER R 168 REMARK 465 ASN R 169 REMARK 465 ASN R 170 REMARK 465 LYS R 171 REMARK 465 TYR R 172 REMARK 465 ALA R 173 REMARK 465 ALA R 174 REMARK 465 SER R 175 REMARK 465 SER R 176 REMARK 465 TYR R 177 REMARK 465 LEU R 178 REMARK 465 SER R 179 REMARK 465 LEU R 180 REMARK 465 THR R 181 REMARK 465 PRO R 182 REMARK 465 GLU R 183 REMARK 465 GLN R 184 REMARK 465 TRP R 185 REMARK 465 LYS R 186 REMARK 465 SER R 187 REMARK 465 HIS R 188 REMARK 465 ARG R 189 REMARK 465 SER R 190 REMARK 465 TYR R 191 REMARK 465 SER R 192 REMARK 465 CYS R 193 REMARK 465 GLN R 194 REMARK 465 VAL R 195 REMARK 465 THR R 196 REMARK 465 HIS R 197 REMARK 465 GLU R 198 REMARK 465 GLY R 199 REMARK 465 SER R 200 REMARK 465 THR R 201 REMARK 465 VAL R 202 REMARK 465 GLU R 203 REMARK 465 LYS R 204 REMARK 465 THR R 205 REMARK 465 VAL R 206 REMARK 465 ALA R 207 REMARK 465 PRO R 208 REMARK 465 THR R 209 REMARK 465 GLU R 210 REMARK 465 CYS R 211 REMARK 465 SER R 212 REMARK 465 SER S 113 REMARK 465 ALA S 114 REMARK 465 SER S 115 REMARK 465 THR S 116 REMARK 465 LYS S 117 REMARK 465 GLY S 118 REMARK 465 PRO S 119 REMARK 465 SER S 120 REMARK 465 VAL S 121 REMARK 465 PHE S 122 REMARK 465 PRO S 123 REMARK 465 LEU S 124 REMARK 465 ALA S 125 REMARK 465 PRO S 126 REMARK 465 SER S 127 REMARK 465 SER S 128 REMARK 465 LYS S 129 REMARK 465 SER S 130 REMARK 465 THR S 131 REMARK 465 SER S 132 REMARK 465 GLY S 133 REMARK 465 GLY S 134 REMARK 465 THR S 135 REMARK 465 ALA S 136 REMARK 465 ALA S 137 REMARK 465 LEU S 138 REMARK 465 GLY S 139 REMARK 465 CYS S 140 REMARK 465 LEU S 141 REMARK 465 VAL S 142 REMARK 465 LYS S 143 REMARK 465 ASP S 144 REMARK 465 TYR S 145 REMARK 465 PHE S 146 REMARK 465 PRO S 147 REMARK 465 GLU S 148 REMARK 465 PRO S 149 REMARK 465 VAL S 150 REMARK 465 THR S 151 REMARK 465 VAL S 152 REMARK 465 SER S 153 REMARK 465 TRP S 154 REMARK 465 ASN S 155 REMARK 465 SER S 156 REMARK 465 GLY S 157 REMARK 465 ALA S 158 REMARK 465 LEU S 159 REMARK 465 THR S 160 REMARK 465 SER S 161 REMARK 465 GLY S 162 REMARK 465 VAL S 163 REMARK 465 HIS S 164 REMARK 465 THR S 165 REMARK 465 PHE S 166 REMARK 465 PRO S 167 REMARK 465 ALA S 168 REMARK 465 VAL S 169 REMARK 465 LEU S 170 REMARK 465 GLN S 171 REMARK 465 SER S 172 REMARK 465 SER S 173 REMARK 465 GLY S 174 REMARK 465 LEU S 175 REMARK 465 TYR S 176 REMARK 465 SER S 177 REMARK 465 LEU S 178 REMARK 465 SER S 179 REMARK 465 SER S 180 REMARK 465 VAL S 181 REMARK 465 VAL S 182 REMARK 465 THR S 183 REMARK 465 VAL S 184 REMARK 465 PRO S 185 REMARK 465 SER S 186 REMARK 465 SER S 187 REMARK 465 SER S 188 REMARK 465 LEU S 189 REMARK 465 GLY S 190 REMARK 465 THR S 191 REMARK 465 GLN S 192 REMARK 465 THR S 193 REMARK 465 TYR S 194 REMARK 465 ILE S 195 REMARK 465 CYS S 196 REMARK 465 ASN S 197 REMARK 465 VAL S 198 REMARK 465 ASN S 199 REMARK 465 HIS S 200 REMARK 465 LYS S 201 REMARK 465 PRO S 202 REMARK 465 SER S 203 REMARK 465 ASN S 204 REMARK 465 THR S 205 REMARK 465 LYS S 206 REMARK 465 VAL S 207 REMARK 465 ASP S 208 REMARK 465 LYS S 209 REMARK 465 ARG S 210 REMARK 465 VAL S 211 REMARK 465 GLU S 212 REMARK 465 PRO S 213 REMARK 465 LYS S 214 REMARK 465 SER S 215 REMARK 465 CYS S 216 REMARK 465 ASP S 217 REMARK 465 LYS S 218 REMARK 465 THR S 219 REMARK 465 HIS S 220 REMARK 465 HIS S 221 REMARK 465 HIS S 222 REMARK 465 HIS S 223 REMARK 465 HIS S 224 REMARK 465 HIS S 225 REMARK 465 GLN T 1 REMARK 465 GLN T 108 REMARK 465 PRO T 109 REMARK 465 LYS T 110 REMARK 465 ALA T 111 REMARK 465 ALA T 112 REMARK 465 PRO T 113 REMARK 465 SER T 114 REMARK 465 VAL T 115 REMARK 465 THR T 116 REMARK 465 LEU T 117 REMARK 465 PHE T 118 REMARK 465 PRO T 119 REMARK 465 PRO T 120 REMARK 465 SER T 121 REMARK 465 SER T 122 REMARK 465 GLU T 123 REMARK 465 GLU T 124 REMARK 465 LEU T 125 REMARK 465 GLN T 126 REMARK 465 ALA T 127 REMARK 465 ASN T 128 REMARK 465 LYS T 129 REMARK 465 ALA T 130 REMARK 465 THR T 131 REMARK 465 LEU T 132 REMARK 465 VAL T 133 REMARK 465 CYS T 134 REMARK 465 LEU T 135 REMARK 465 ILE T 136 REMARK 465 SER T 137 REMARK 465 ASP T 138 REMARK 465 PHE T 139 REMARK 465 TYR T 140 REMARK 465 PRO T 141 REMARK 465 GLY T 142 REMARK 465 ALA T 143 REMARK 465 VAL T 144 REMARK 465 THR T 145 REMARK 465 VAL T 146 REMARK 465 ALA T 147 REMARK 465 TRP T 148 REMARK 465 LYS T 149 REMARK 465 ALA T 150 REMARK 465 ASP T 151 REMARK 465 SER T 152 REMARK 465 SER T 153 REMARK 465 PRO T 154 REMARK 465 VAL T 155 REMARK 465 LYS T 156 REMARK 465 ALA T 157 REMARK 465 GLY T 158 REMARK 465 VAL T 159 REMARK 465 GLU T 160 REMARK 465 THR T 161 REMARK 465 THR T 162 REMARK 465 THR T 163 REMARK 465 PRO T 164 REMARK 465 SER T 165 REMARK 465 LYS T 166 REMARK 465 GLN T 167 REMARK 465 SER T 168 REMARK 465 ASN T 169 REMARK 465 ASN T 170 REMARK 465 LYS T 171 REMARK 465 TYR T 172 REMARK 465 ALA T 173 REMARK 465 ALA T 174 REMARK 465 SER T 175 REMARK 465 SER T 176 REMARK 465 TYR T 177 REMARK 465 LEU T 178 REMARK 465 SER T 179 REMARK 465 LEU T 180 REMARK 465 THR T 181 REMARK 465 PRO T 182 REMARK 465 GLU T 183 REMARK 465 GLN T 184 REMARK 465 TRP T 185 REMARK 465 LYS T 186 REMARK 465 SER T 187 REMARK 465 HIS T 188 REMARK 465 ARG T 189 REMARK 465 SER T 190 REMARK 465 TYR T 191 REMARK 465 SER T 192 REMARK 465 CYS T 193 REMARK 465 GLN T 194 REMARK 465 VAL T 195 REMARK 465 THR T 196 REMARK 465 HIS T 197 REMARK 465 GLU T 198 REMARK 465 GLY T 199 REMARK 465 SER T 200 REMARK 465 THR T 201 REMARK 465 VAL T 202 REMARK 465 GLU T 203 REMARK 465 LYS T 204 REMARK 465 THR T 205 REMARK 465 VAL T 206 REMARK 465 ALA T 207 REMARK 465 PRO T 208 REMARK 465 THR T 209 REMARK 465 GLU T 210 REMARK 465 CYS T 211 REMARK 465 SER T 212 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS H 43 CE NZ REMARK 470 SER L 2 OG REMARK 470 LYS M 43 CE NZ REMARK 470 SER N 2 OG REMARK 470 LYS O 43 CE NZ REMARK 470 SER P 2 OG REMARK 470 LYS Q 43 CE NZ REMARK 470 SER R 2 OG REMARK 470 LYS S 43 CE NZ REMARK 470 SER T 2 OG REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN A 70 12.05 -152.49 REMARK 500 LEU A 82 34.42 -97.43 REMARK 500 VAL A 155 107.29 31.60 REMARK 500 HIS A 182 155.50 179.64 REMARK 500 THR A 207 149.92 -171.69 REMARK 500 ARG A 266 46.78 -140.84 REMARK 500 MET A 269 -179.65 -175.12 REMARK 500 LEU A 289 32.10 -97.93 REMARK 500 TYR A 290 157.42 177.65 REMARK 500 SER A 312 -173.52 -65.77 REMARK 500 MET A 313 125.31 -36.56 REMARK 500 LEU A 327 30.06 -96.23 REMARK 500 SER A 357 -156.71 -73.02 REMARK 500 LEU A 358 60.12 172.36 REMARK 500 ASN B 70 12.05 -152.47 REMARK 500 LEU B 82 34.41 -97.36 REMARK 500 VAL B 155 107.27 31.57 REMARK 500 THR B 207 149.90 -171.70 REMARK 500 ARG B 266 46.85 -140.85 REMARK 500 MET B 269 -179.65 -175.12 REMARK 500 LEU B 289 32.09 -97.98 REMARK 500 TYR B 290 157.43 177.65 REMARK 500 SER B 312 -173.53 -65.68 REMARK 500 MET B 313 125.32 -36.56 REMARK 500 LEU B 327 30.09 -96.25 REMARK 500 SER B 357 -157.57 -70.26 REMARK 500 LEU B 358 72.21 171.24 REMARK 500 ASN C 70 12.01 -152.44 REMARK 500 LEU C 82 34.40 -97.36 REMARK 500 VAL C 155 107.28 31.61 REMARK 500 THR C 207 149.92 -171.69 REMARK 500 ASN C 230 -37.19 -38.75 REMARK 500 ARG C 266 46.78 -140.92 REMARK 500 MET C 269 -179.62 -175.07 REMARK 500 LEU C 289 32.14 -97.97 REMARK 500 TYR C 290 157.50 177.67 REMARK 500 SER C 312 -173.54 -65.74 REMARK 500 MET C 313 125.34 -36.48 REMARK 500 LEU C 327 30.12 -96.27 REMARK 500 SER C 357 -158.95 -66.97 REMARK 500 LEU C 358 65.87 173.65 REMARK 500 ASN D 70 12.06 -152.48 REMARK 500 LEU D 82 34.42 -97.39 REMARK 500 VAL D 155 107.28 31.60 REMARK 500 HIS D 182 157.90 178.74 REMARK 500 THR D 207 149.88 -171.64 REMARK 500 ASN D 230 -38.60 -35.24 REMARK 500 SER D 232 -12.86 -152.97 REMARK 500 ARG D 266 46.79 -140.89 REMARK 500 MET D 269 -179.65 -175.05 REMARK 500 REMARK 500 THIS ENTRY HAS 77 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG A 480 0.27 SIDE CHAIN REMARK 500 ARG B 480 0.27 SIDE CHAIN REMARK 500 ARG C 480 0.27 SIDE CHAIN REMARK 500 ARG D 480 0.26 SIDE CHAIN REMARK 500 ARG E 480 0.26 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-48344 RELATED DB: EMDB REMARK 900 D24.1M01 FAB BOUND TO HPV16 L1 PENTAMER DBREF1 9ML1 A 35 488 UNP A0A161GYK1_HPV16 DBREF2 9ML1 A A0A161GYK1 47 500 DBREF1 9ML1 B 35 488 UNP A0A161GYK1_HPV16 DBREF2 9ML1 B A0A161GYK1 47 500 DBREF1 9ML1 C 35 488 UNP A0A161GYK1_HPV16 DBREF2 9ML1 C A0A161GYK1 47 500 DBREF1 9ML1 D 35 488 UNP A0A161GYK1_HPV16 DBREF2 9ML1 D A0A161GYK1 47 500 DBREF1 9ML1 E 35 488 UNP A0A161GYK1_HPV16 DBREF2 9ML1 E A0A161GYK1 47 500 DBREF 9ML1 H 1 225 PDB 9ML1 9ML1 1 225 DBREF 9ML1 L 1 212 PDB 9ML1 9ML1 1 212 DBREF 9ML1 M 1 225 PDB 9ML1 9ML1 1 225 DBREF 9ML1 N 1 212 PDB 9ML1 9ML1 1 212 DBREF 9ML1 O 1 225 PDB 9ML1 9ML1 1 225 DBREF 9ML1 P 1 212 PDB 9ML1 9ML1 1 212 DBREF 9ML1 Q 1 225 PDB 9ML1 9ML1 1 225 DBREF 9ML1 R 1 212 PDB 9ML1 9ML1 1 212 DBREF 9ML1 S 1 225 PDB 9ML1 9ML1 1 225 DBREF 9ML1 T 1 212 PDB 9ML1 9ML1 1 212 SEQADV 9ML1 ALA A 34 UNP A0A161GYK EXPRESSION TAG SEQADV 9ML1 THR A 280 UNP A0A161GYK ALA 292 CONFLICT SEQADV 9ML1 A UNP A0A161GYK PHE 430 DELETION SEQADV 9ML1 A UNP A0A161GYK GLY 431 DELETION SEQADV 9ML1 A UNP A0A161GYK LEU 432 DELETION SEQADV 9ML1 A UNP A0A161GYK GLN 433 DELETION SEQADV 9ML1 A UNP A0A161GYK PRO 434 DELETION SEQADV 9ML1 A UNP A0A161GYK PRO 435 DELETION SEQADV 9ML1 A UNP A0A161GYK PRO 436 DELETION SEQADV 9ML1 SER A 448 UNP A0A161GYK THR 439 CONFLICT SEQADV 9ML1 A UNP A0A161GYK LEU 440 DELETION SEQADV 9ML1 A UNP A0A161GYK GLU 441 DELETION SEQADV 9ML1 A UNP A0A161GYK ASP 442 DELETION SEQADV 9ML1 A UNP A0A161GYK THR 443 DELETION SEQADV 9ML1 A UNP A0A161GYK TYR 444 DELETION SEQADV 9ML1 A UNP A0A161GYK ARG 445 DELETION SEQADV 9ML1 A UNP A0A161GYK PHE 446 DELETION SEQADV 9ML1 A UNP A0A161GYK VAL 447 DELETION SEQADV 9ML1 A UNP A0A161GYK THR 448 DELETION SEQADV 9ML1 A UNP A0A161GYK SER 449 DELETION SEQADV 9ML1 A UNP A0A161GYK GLN 450 DELETION SEQADV 9ML1 A UNP A0A161GYK ALA 451 DELETION SEQADV 9ML1 A UNP A0A161GYK ILE 452 DELETION SEQADV 9ML1 A UNP A0A161GYK ALA 453 DELETION SEQADV 9ML1 A UNP A0A161GYK CYS 454 DELETION SEQADV 9ML1 A UNP A0A161GYK GLN 455 DELETION SEQADV 9ML1 A UNP A0A161GYK LYS 456 DELETION SEQADV 9ML1 A UNP A0A161GYK HIS 457 DELETION SEQADV 9ML1 A UNP A0A161GYK THR 458 DELETION SEQADV 9ML1 A UNP A0A161GYK PRO 459 DELETION SEQADV 9ML1 A UNP A0A161GYK PRO 460 DELETION SEQADV 9ML1 A UNP A0A161GYK VAL 461 DELETION SEQADV 9ML1 GLY A 449 UNP A0A161GYK PRO 462 CONFLICT SEQADV 9ML1 ALA A 450 UNP A0A161GYK LYS 463 CONFLICT SEQADV 9ML1 ALA B 34 UNP A0A161GYK EXPRESSION TAG SEQADV 9ML1 THR B 280 UNP A0A161GYK ALA 292 CONFLICT SEQADV 9ML1 B UNP A0A161GYK PHE 430 DELETION SEQADV 9ML1 B UNP A0A161GYK GLY 431 DELETION SEQADV 9ML1 B UNP A0A161GYK LEU 432 DELETION SEQADV 9ML1 B UNP A0A161GYK GLN 433 DELETION SEQADV 9ML1 B UNP A0A161GYK PRO 434 DELETION SEQADV 9ML1 B UNP A0A161GYK PRO 435 DELETION SEQADV 9ML1 B UNP A0A161GYK PRO 436 DELETION SEQADV 9ML1 SER B 448 UNP A0A161GYK THR 439 CONFLICT SEQADV 9ML1 B UNP A0A161GYK LEU 440 DELETION SEQADV 9ML1 B UNP A0A161GYK GLU 441 DELETION SEQADV 9ML1 B UNP A0A161GYK ASP 442 DELETION SEQADV 9ML1 B UNP A0A161GYK THR 443 DELETION SEQADV 9ML1 B UNP A0A161GYK TYR 444 DELETION SEQADV 9ML1 B UNP A0A161GYK ARG 445 DELETION SEQADV 9ML1 B UNP A0A161GYK PHE 446 DELETION SEQADV 9ML1 B UNP A0A161GYK VAL 447 DELETION SEQADV 9ML1 B UNP A0A161GYK THR 448 DELETION SEQADV 9ML1 B UNP A0A161GYK SER 449 DELETION SEQADV 9ML1 B UNP A0A161GYK GLN 450 DELETION SEQADV 9ML1 B UNP A0A161GYK ALA 451 DELETION SEQADV 9ML1 B UNP A0A161GYK ILE 452 DELETION SEQADV 9ML1 B UNP A0A161GYK ALA 453 DELETION SEQADV 9ML1 B UNP A0A161GYK CYS 454 DELETION SEQADV 9ML1 B UNP A0A161GYK GLN 455 DELETION SEQADV 9ML1 B UNP A0A161GYK LYS 456 DELETION SEQADV 9ML1 B UNP A0A161GYK HIS 457 DELETION SEQADV 9ML1 B UNP A0A161GYK THR 458 DELETION SEQADV 9ML1 B UNP A0A161GYK PRO 459 DELETION SEQADV 9ML1 B UNP A0A161GYK PRO 460 DELETION SEQADV 9ML1 B UNP A0A161GYK VAL 461 DELETION SEQADV 9ML1 GLY B 449 UNP A0A161GYK PRO 462 CONFLICT SEQADV 9ML1 ALA B 450 UNP A0A161GYK LYS 463 CONFLICT SEQADV 9ML1 ALA C 34 UNP A0A161GYK EXPRESSION TAG SEQADV 9ML1 THR C 280 UNP A0A161GYK ALA 292 CONFLICT SEQADV 9ML1 C UNP A0A161GYK PHE 430 DELETION SEQADV 9ML1 C UNP A0A161GYK GLY 431 DELETION SEQADV 9ML1 C UNP A0A161GYK LEU 432 DELETION SEQADV 9ML1 C UNP A0A161GYK GLN 433 DELETION SEQADV 9ML1 C UNP A0A161GYK PRO 434 DELETION SEQADV 9ML1 C UNP A0A161GYK PRO 435 DELETION SEQADV 9ML1 C UNP A0A161GYK PRO 436 DELETION SEQADV 9ML1 SER C 448 UNP A0A161GYK THR 439 CONFLICT SEQADV 9ML1 C UNP A0A161GYK LEU 440 DELETION SEQADV 9ML1 C UNP A0A161GYK GLU 441 DELETION SEQADV 9ML1 C UNP A0A161GYK ASP 442 DELETION SEQADV 9ML1 C UNP A0A161GYK THR 443 DELETION SEQADV 9ML1 C UNP A0A161GYK TYR 444 DELETION SEQADV 9ML1 C UNP A0A161GYK ARG 445 DELETION SEQADV 9ML1 C UNP A0A161GYK PHE 446 DELETION SEQADV 9ML1 C UNP A0A161GYK VAL 447 DELETION SEQADV 9ML1 C UNP A0A161GYK THR 448 DELETION SEQADV 9ML1 C UNP A0A161GYK SER 449 DELETION SEQADV 9ML1 C UNP A0A161GYK GLN 450 DELETION SEQADV 9ML1 C UNP A0A161GYK ALA 451 DELETION SEQADV 9ML1 C UNP A0A161GYK ILE 452 DELETION SEQADV 9ML1 C UNP A0A161GYK ALA 453 DELETION SEQADV 9ML1 C UNP A0A161GYK CYS 454 DELETION SEQADV 9ML1 C UNP A0A161GYK GLN 455 DELETION SEQADV 9ML1 C UNP A0A161GYK LYS 456 DELETION SEQADV 9ML1 C UNP A0A161GYK HIS 457 DELETION SEQADV 9ML1 C UNP A0A161GYK THR 458 DELETION SEQADV 9ML1 C UNP A0A161GYK PRO 459 DELETION SEQADV 9ML1 C UNP A0A161GYK PRO 460 DELETION SEQADV 9ML1 C UNP A0A161GYK VAL 461 DELETION SEQADV 9ML1 GLY C 449 UNP A0A161GYK PRO 462 CONFLICT SEQADV 9ML1 ALA C 450 UNP A0A161GYK LYS 463 CONFLICT SEQADV 9ML1 ALA D 34 UNP A0A161GYK EXPRESSION TAG SEQADV 9ML1 THR D 280 UNP A0A161GYK ALA 292 CONFLICT SEQADV 9ML1 D UNP A0A161GYK PHE 430 DELETION SEQADV 9ML1 D UNP A0A161GYK GLY 431 DELETION SEQADV 9ML1 D UNP A0A161GYK LEU 432 DELETION SEQADV 9ML1 D UNP A0A161GYK GLN 433 DELETION SEQADV 9ML1 D UNP A0A161GYK PRO 434 DELETION SEQADV 9ML1 D UNP A0A161GYK PRO 435 DELETION SEQADV 9ML1 D UNP A0A161GYK PRO 436 DELETION SEQADV 9ML1 SER D 448 UNP A0A161GYK THR 439 CONFLICT SEQADV 9ML1 D UNP A0A161GYK LEU 440 DELETION SEQADV 9ML1 D UNP A0A161GYK GLU 441 DELETION SEQADV 9ML1 D UNP A0A161GYK ASP 442 DELETION SEQADV 9ML1 D UNP A0A161GYK THR 443 DELETION SEQADV 9ML1 D UNP A0A161GYK TYR 444 DELETION SEQADV 9ML1 D UNP A0A161GYK ARG 445 DELETION SEQADV 9ML1 D UNP A0A161GYK PHE 446 DELETION SEQADV 9ML1 D UNP A0A161GYK VAL 447 DELETION SEQADV 9ML1 D UNP A0A161GYK THR 448 DELETION SEQADV 9ML1 D UNP A0A161GYK SER 449 DELETION SEQADV 9ML1 D UNP A0A161GYK GLN 450 DELETION SEQADV 9ML1 D UNP A0A161GYK ALA 451 DELETION SEQADV 9ML1 D UNP A0A161GYK ILE 452 DELETION SEQADV 9ML1 D UNP A0A161GYK ALA 453 DELETION SEQADV 9ML1 D UNP A0A161GYK CYS 454 DELETION SEQADV 9ML1 D UNP A0A161GYK GLN 455 DELETION SEQADV 9ML1 D UNP A0A161GYK LYS 456 DELETION SEQADV 9ML1 D UNP A0A161GYK HIS 457 DELETION SEQADV 9ML1 D UNP A0A161GYK THR 458 DELETION SEQADV 9ML1 D UNP A0A161GYK PRO 459 DELETION SEQADV 9ML1 D UNP A0A161GYK PRO 460 DELETION SEQADV 9ML1 D UNP A0A161GYK VAL 461 DELETION SEQADV 9ML1 GLY D 449 UNP A0A161GYK PRO 462 CONFLICT SEQADV 9ML1 ALA D 450 UNP A0A161GYK LYS 463 CONFLICT SEQADV 9ML1 ALA E 34 UNP A0A161GYK EXPRESSION TAG SEQADV 9ML1 THR E 280 UNP A0A161GYK ALA 292 CONFLICT SEQADV 9ML1 E UNP A0A161GYK PHE 430 DELETION SEQADV 9ML1 E UNP A0A161GYK GLY 431 DELETION SEQADV 9ML1 E UNP A0A161GYK LEU 432 DELETION SEQADV 9ML1 E UNP A0A161GYK GLN 433 DELETION SEQADV 9ML1 E UNP A0A161GYK PRO 434 DELETION SEQADV 9ML1 E UNP A0A161GYK PRO 435 DELETION SEQADV 9ML1 E UNP A0A161GYK PRO 436 DELETION SEQADV 9ML1 SER E 448 UNP A0A161GYK THR 439 CONFLICT SEQADV 9ML1 E UNP A0A161GYK LEU 440 DELETION SEQADV 9ML1 E UNP A0A161GYK GLU 441 DELETION SEQADV 9ML1 E UNP A0A161GYK ASP 442 DELETION SEQADV 9ML1 E UNP A0A161GYK THR 443 DELETION SEQADV 9ML1 E UNP A0A161GYK TYR 444 DELETION SEQADV 9ML1 E UNP A0A161GYK ARG 445 DELETION SEQADV 9ML1 E UNP A0A161GYK PHE 446 DELETION SEQADV 9ML1 E UNP A0A161GYK VAL 447 DELETION SEQADV 9ML1 E UNP A0A161GYK THR 448 DELETION SEQADV 9ML1 E UNP A0A161GYK SER 449 DELETION SEQADV 9ML1 E UNP A0A161GYK GLN 450 DELETION SEQADV 9ML1 E UNP A0A161GYK ALA 451 DELETION SEQADV 9ML1 E UNP A0A161GYK ILE 452 DELETION SEQADV 9ML1 E UNP A0A161GYK ALA 453 DELETION SEQADV 9ML1 E UNP A0A161GYK CYS 454 DELETION SEQADV 9ML1 E UNP A0A161GYK GLN 455 DELETION SEQADV 9ML1 E UNP A0A161GYK LYS 456 DELETION SEQADV 9ML1 E UNP A0A161GYK HIS 457 DELETION SEQADV 9ML1 E UNP A0A161GYK THR 458 DELETION SEQADV 9ML1 E UNP A0A161GYK PRO 459 DELETION SEQADV 9ML1 E UNP A0A161GYK PRO 460 DELETION SEQADV 9ML1 E UNP A0A161GYK VAL 461 DELETION SEQADV 9ML1 GLY E 449 UNP A0A161GYK PRO 462 CONFLICT SEQADV 9ML1 ALA E 450 UNP A0A161GYK LYS 463 CONFLICT SEQRES 1 A 426 ALA VAL VAL SER THR ASP GLU TYR VAL ALA ARG THR ASN SEQRES 2 A 426 ILE TYR TYR HIS ALA GLY THR SER ARG LEU LEU ALA VAL SEQRES 3 A 426 GLY HIS PRO TYR PHE PRO ILE LYS LYS PRO ASN ASN ASN SEQRES 4 A 426 LYS ILE LEU VAL PRO LYS VAL SER GLY LEU GLN TYR ARG SEQRES 5 A 426 VAL PHE ARG ILE HIS LEU PRO ASP PRO ASN LYS PHE GLY SEQRES 6 A 426 PHE PRO ASP THR SER PHE TYR ASN PRO ASP THR GLN ARG SEQRES 7 A 426 LEU VAL TRP ALA CYS VAL GLY VAL GLU VAL GLY ARG GLY SEQRES 8 A 426 GLN PRO LEU GLY VAL GLY ILE SER GLY HIS PRO LEU LEU SEQRES 9 A 426 ASN LYS LEU ASP ASP THR GLU ASN ALA SER ALA TYR ALA SEQRES 10 A 426 ALA ASN ALA GLY VAL ASP ASN ARG GLU CYS ILE SER MET SEQRES 11 A 426 ASP TYR LYS GLN THR GLN LEU CYS LEU ILE GLY CYS LYS SEQRES 12 A 426 PRO PRO ILE GLY GLU HIS TRP GLY LYS GLY SER PRO CYS SEQRES 13 A 426 THR ASN VAL ALA VAL ASN PRO GLY ASP CYS PRO PRO LEU SEQRES 14 A 426 GLU LEU ILE ASN THR VAL ILE GLN ASP GLY ASP MET VAL SEQRES 15 A 426 ASP THR GLY PHE GLY ALA MET ASP PHE THR THR LEU GLN SEQRES 16 A 426 ALA ASN LYS SER GLU VAL PRO LEU ASP ILE CYS THR SER SEQRES 17 A 426 ILE CYS LYS TYR PRO ASP TYR ILE LYS MET VAL SER GLU SEQRES 18 A 426 PRO TYR GLY ASP SER LEU PHE PHE TYR LEU ARG ARG GLU SEQRES 19 A 426 GLN MET PHE VAL ARG HIS LEU PHE ASN ARG ALA GLY THR SEQRES 20 A 426 VAL GLY GLU ASN VAL PRO ASP ASP LEU TYR ILE LYS GLY SEQRES 21 A 426 SER GLY SER THR ALA ASN LEU ALA SER SER ASN TYR PHE SEQRES 22 A 426 PRO THR PRO SER GLY SER MET VAL THR SER ASP ALA GLN SEQRES 23 A 426 ILE PHE ASN LYS PRO TYR TRP LEU GLN ARG ALA GLN GLY SEQRES 24 A 426 HIS ASN ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL SEQRES 25 A 426 THR VAL VAL ASP THR THR ARG SER THR ASN MET SER LEU SEQRES 26 A 426 CYS ALA ALA ILE SER THR SER GLU THR THR TYR LYS ASN SEQRES 27 A 426 THR ASN PHE LYS GLU TYR LEU ARG HIS GLY GLU GLU TYR SEQRES 28 A 426 ASP LEU GLN PHE ILE PHE GLN LEU CYS LYS ILE THR LEU SEQRES 29 A 426 THR ALA ASP VAL MET THR TYR ILE HIS SER MET ASN SER SEQRES 30 A 426 THR ILE LEU GLU ASP TRP ASN GLY GLY SER GLY ALA GLU SEQRES 31 A 426 ASP PRO LEU LYS LYS TYR THR PHE TRP GLU VAL ASN LEU SEQRES 32 A 426 LYS GLU LYS PHE SER ALA ASP LEU ASP GLN PHE PRO LEU SEQRES 33 A 426 GLY ARG LYS PHE LEU LEU GLN ALA GLY LEU SEQRES 1 B 426 ALA VAL VAL SER THR ASP GLU TYR VAL ALA ARG THR ASN SEQRES 2 B 426 ILE TYR TYR HIS ALA GLY THR SER ARG LEU LEU ALA VAL SEQRES 3 B 426 GLY HIS PRO TYR PHE PRO ILE LYS LYS PRO ASN ASN ASN SEQRES 4 B 426 LYS ILE LEU VAL PRO LYS VAL SER GLY LEU GLN TYR ARG SEQRES 5 B 426 VAL PHE ARG ILE HIS LEU PRO ASP PRO ASN LYS PHE GLY SEQRES 6 B 426 PHE PRO ASP THR SER PHE TYR ASN PRO ASP THR GLN ARG SEQRES 7 B 426 LEU VAL TRP ALA CYS VAL GLY VAL GLU VAL GLY ARG GLY SEQRES 8 B 426 GLN PRO LEU GLY VAL GLY ILE SER GLY HIS PRO LEU LEU SEQRES 9 B 426 ASN LYS LEU ASP ASP THR GLU ASN ALA SER ALA TYR ALA SEQRES 10 B 426 ALA ASN ALA GLY VAL ASP ASN ARG GLU CYS ILE SER MET SEQRES 11 B 426 ASP TYR LYS GLN THR GLN LEU CYS LEU ILE GLY CYS LYS SEQRES 12 B 426 PRO PRO ILE GLY GLU HIS TRP GLY LYS GLY SER PRO CYS SEQRES 13 B 426 THR ASN VAL ALA VAL ASN PRO GLY ASP CYS PRO PRO LEU SEQRES 14 B 426 GLU LEU ILE ASN THR VAL ILE GLN ASP GLY ASP MET VAL SEQRES 15 B 426 ASP THR GLY PHE GLY ALA MET ASP PHE THR THR LEU GLN SEQRES 16 B 426 ALA ASN LYS SER GLU VAL PRO LEU ASP ILE CYS THR SER SEQRES 17 B 426 ILE CYS LYS TYR PRO ASP TYR ILE LYS MET VAL SER GLU SEQRES 18 B 426 PRO TYR GLY ASP SER LEU PHE PHE TYR LEU ARG ARG GLU SEQRES 19 B 426 GLN MET PHE VAL ARG HIS LEU PHE ASN ARG ALA GLY THR SEQRES 20 B 426 VAL GLY GLU ASN VAL PRO ASP ASP LEU TYR ILE LYS GLY SEQRES 21 B 426 SER GLY SER THR ALA ASN LEU ALA SER SER ASN TYR PHE SEQRES 22 B 426 PRO THR PRO SER GLY SER MET VAL THR SER ASP ALA GLN SEQRES 23 B 426 ILE PHE ASN LYS PRO TYR TRP LEU GLN ARG ALA GLN GLY SEQRES 24 B 426 HIS ASN ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL SEQRES 25 B 426 THR VAL VAL ASP THR THR ARG SER THR ASN MET SER LEU SEQRES 26 B 426 CYS ALA ALA ILE SER THR SER GLU THR THR TYR LYS ASN SEQRES 27 B 426 THR ASN PHE LYS GLU TYR LEU ARG HIS GLY GLU GLU TYR SEQRES 28 B 426 ASP LEU GLN PHE ILE PHE GLN LEU CYS LYS ILE THR LEU SEQRES 29 B 426 THR ALA ASP VAL MET THR TYR ILE HIS SER MET ASN SER SEQRES 30 B 426 THR ILE LEU GLU ASP TRP ASN GLY GLY SER GLY ALA GLU SEQRES 31 B 426 ASP PRO LEU LYS LYS TYR THR PHE TRP GLU VAL ASN LEU SEQRES 32 B 426 LYS GLU LYS PHE SER ALA ASP LEU ASP GLN PHE PRO LEU SEQRES 33 B 426 GLY ARG LYS PHE LEU LEU GLN ALA GLY LEU SEQRES 1 C 426 ALA VAL VAL SER THR ASP GLU TYR VAL ALA ARG THR ASN SEQRES 2 C 426 ILE TYR TYR HIS ALA GLY THR SER ARG LEU LEU ALA VAL SEQRES 3 C 426 GLY HIS PRO TYR PHE PRO ILE LYS LYS PRO ASN ASN ASN SEQRES 4 C 426 LYS ILE LEU VAL PRO LYS VAL SER GLY LEU GLN TYR ARG SEQRES 5 C 426 VAL PHE ARG ILE HIS LEU PRO ASP PRO ASN LYS PHE GLY SEQRES 6 C 426 PHE PRO ASP THR SER PHE TYR ASN PRO ASP THR GLN ARG SEQRES 7 C 426 LEU VAL TRP ALA CYS VAL GLY VAL GLU VAL GLY ARG GLY SEQRES 8 C 426 GLN PRO LEU GLY VAL GLY ILE SER GLY HIS PRO LEU LEU SEQRES 9 C 426 ASN LYS LEU ASP ASP THR GLU ASN ALA SER ALA TYR ALA SEQRES 10 C 426 ALA ASN ALA GLY VAL ASP ASN ARG GLU CYS ILE SER MET SEQRES 11 C 426 ASP TYR LYS GLN THR GLN LEU CYS LEU ILE GLY CYS LYS SEQRES 12 C 426 PRO PRO ILE GLY GLU HIS TRP GLY LYS GLY SER PRO CYS SEQRES 13 C 426 THR ASN VAL ALA VAL ASN PRO GLY ASP CYS PRO PRO LEU SEQRES 14 C 426 GLU LEU ILE ASN THR VAL ILE GLN ASP GLY ASP MET VAL SEQRES 15 C 426 ASP THR GLY PHE GLY ALA MET ASP PHE THR THR LEU GLN SEQRES 16 C 426 ALA ASN LYS SER GLU VAL PRO LEU ASP ILE CYS THR SER SEQRES 17 C 426 ILE CYS LYS TYR PRO ASP TYR ILE LYS MET VAL SER GLU SEQRES 18 C 426 PRO TYR GLY ASP SER LEU PHE PHE TYR LEU ARG ARG GLU SEQRES 19 C 426 GLN MET PHE VAL ARG HIS LEU PHE ASN ARG ALA GLY THR SEQRES 20 C 426 VAL GLY GLU ASN VAL PRO ASP ASP LEU TYR ILE LYS GLY SEQRES 21 C 426 SER GLY SER THR ALA ASN LEU ALA SER SER ASN TYR PHE SEQRES 22 C 426 PRO THR PRO SER GLY SER MET VAL THR SER ASP ALA GLN SEQRES 23 C 426 ILE PHE ASN LYS PRO TYR TRP LEU GLN ARG ALA GLN GLY SEQRES 24 C 426 HIS ASN ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL SEQRES 25 C 426 THR VAL VAL ASP THR THR ARG SER THR ASN MET SER LEU SEQRES 26 C 426 CYS ALA ALA ILE SER THR SER GLU THR THR TYR LYS ASN SEQRES 27 C 426 THR ASN PHE LYS GLU TYR LEU ARG HIS GLY GLU GLU TYR SEQRES 28 C 426 ASP LEU GLN PHE ILE PHE GLN LEU CYS LYS ILE THR LEU SEQRES 29 C 426 THR ALA ASP VAL MET THR TYR ILE HIS SER MET ASN SER SEQRES 30 C 426 THR ILE LEU GLU ASP TRP ASN GLY GLY SER GLY ALA GLU SEQRES 31 C 426 ASP PRO LEU LYS LYS TYR THR PHE TRP GLU VAL ASN LEU SEQRES 32 C 426 LYS GLU LYS PHE SER ALA ASP LEU ASP GLN PHE PRO LEU SEQRES 33 C 426 GLY ARG LYS PHE LEU LEU GLN ALA GLY LEU SEQRES 1 D 426 ALA VAL VAL SER THR ASP GLU TYR VAL ALA ARG THR ASN SEQRES 2 D 426 ILE TYR TYR HIS ALA GLY THR SER ARG LEU LEU ALA VAL SEQRES 3 D 426 GLY HIS PRO TYR PHE PRO ILE LYS LYS PRO ASN ASN ASN SEQRES 4 D 426 LYS ILE LEU VAL PRO LYS VAL SER GLY LEU GLN TYR ARG SEQRES 5 D 426 VAL PHE ARG ILE HIS LEU PRO ASP PRO ASN LYS PHE GLY SEQRES 6 D 426 PHE PRO ASP THR SER PHE TYR ASN PRO ASP THR GLN ARG SEQRES 7 D 426 LEU VAL TRP ALA CYS VAL GLY VAL GLU VAL GLY ARG GLY SEQRES 8 D 426 GLN PRO LEU GLY VAL GLY ILE SER GLY HIS PRO LEU LEU SEQRES 9 D 426 ASN LYS LEU ASP ASP THR GLU ASN ALA SER ALA TYR ALA SEQRES 10 D 426 ALA ASN ALA GLY VAL ASP ASN ARG GLU CYS ILE SER MET SEQRES 11 D 426 ASP TYR LYS GLN THR GLN LEU CYS LEU ILE GLY CYS LYS SEQRES 12 D 426 PRO PRO ILE GLY GLU HIS TRP GLY LYS GLY SER PRO CYS SEQRES 13 D 426 THR ASN VAL ALA VAL ASN PRO GLY ASP CYS PRO PRO LEU SEQRES 14 D 426 GLU LEU ILE ASN THR VAL ILE GLN ASP GLY ASP MET VAL SEQRES 15 D 426 ASP THR GLY PHE GLY ALA MET ASP PHE THR THR LEU GLN SEQRES 16 D 426 ALA ASN LYS SER GLU VAL PRO LEU ASP ILE CYS THR SER SEQRES 17 D 426 ILE CYS LYS TYR PRO ASP TYR ILE LYS MET VAL SER GLU SEQRES 18 D 426 PRO TYR GLY ASP SER LEU PHE PHE TYR LEU ARG ARG GLU SEQRES 19 D 426 GLN MET PHE VAL ARG HIS LEU PHE ASN ARG ALA GLY THR SEQRES 20 D 426 VAL GLY GLU ASN VAL PRO ASP ASP LEU TYR ILE LYS GLY SEQRES 21 D 426 SER GLY SER THR ALA ASN LEU ALA SER SER ASN TYR PHE SEQRES 22 D 426 PRO THR PRO SER GLY SER MET VAL THR SER ASP ALA GLN SEQRES 23 D 426 ILE PHE ASN LYS PRO TYR TRP LEU GLN ARG ALA GLN GLY SEQRES 24 D 426 HIS ASN ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL SEQRES 25 D 426 THR VAL VAL ASP THR THR ARG SER THR ASN MET SER LEU SEQRES 26 D 426 CYS ALA ALA ILE SER THR SER GLU THR THR TYR LYS ASN SEQRES 27 D 426 THR ASN PHE LYS GLU TYR LEU ARG HIS GLY GLU GLU TYR SEQRES 28 D 426 ASP LEU GLN PHE ILE PHE GLN LEU CYS LYS ILE THR LEU SEQRES 29 D 426 THR ALA ASP VAL MET THR TYR ILE HIS SER MET ASN SER SEQRES 30 D 426 THR ILE LEU GLU ASP TRP ASN GLY GLY SER GLY ALA GLU SEQRES 31 D 426 ASP PRO LEU LYS LYS TYR THR PHE TRP GLU VAL ASN LEU SEQRES 32 D 426 LYS GLU LYS PHE SER ALA ASP LEU ASP GLN PHE PRO LEU SEQRES 33 D 426 GLY ARG LYS PHE LEU LEU GLN ALA GLY LEU SEQRES 1 E 426 ALA VAL VAL SER THR ASP GLU TYR VAL ALA ARG THR ASN SEQRES 2 E 426 ILE TYR TYR HIS ALA GLY THR SER ARG LEU LEU ALA VAL SEQRES 3 E 426 GLY HIS PRO TYR PHE PRO ILE LYS LYS PRO ASN ASN ASN SEQRES 4 E 426 LYS ILE LEU VAL PRO LYS VAL SER GLY LEU GLN TYR ARG SEQRES 5 E 426 VAL PHE ARG ILE HIS LEU PRO ASP PRO ASN LYS PHE GLY SEQRES 6 E 426 PHE PRO ASP THR SER PHE TYR ASN PRO ASP THR GLN ARG SEQRES 7 E 426 LEU VAL TRP ALA CYS VAL GLY VAL GLU VAL GLY ARG GLY SEQRES 8 E 426 GLN PRO LEU GLY VAL GLY ILE SER GLY HIS PRO LEU LEU SEQRES 9 E 426 ASN LYS LEU ASP ASP THR GLU ASN ALA SER ALA TYR ALA SEQRES 10 E 426 ALA ASN ALA GLY VAL ASP ASN ARG GLU CYS ILE SER MET SEQRES 11 E 426 ASP TYR LYS GLN THR GLN LEU CYS LEU ILE GLY CYS LYS SEQRES 12 E 426 PRO PRO ILE GLY GLU HIS TRP GLY LYS GLY SER PRO CYS SEQRES 13 E 426 THR ASN VAL ALA VAL ASN PRO GLY ASP CYS PRO PRO LEU SEQRES 14 E 426 GLU LEU ILE ASN THR VAL ILE GLN ASP GLY ASP MET VAL SEQRES 15 E 426 ASP THR GLY PHE GLY ALA MET ASP PHE THR THR LEU GLN SEQRES 16 E 426 ALA ASN LYS SER GLU VAL PRO LEU ASP ILE CYS THR SER SEQRES 17 E 426 ILE CYS LYS TYR PRO ASP TYR ILE LYS MET VAL SER GLU SEQRES 18 E 426 PRO TYR GLY ASP SER LEU PHE PHE TYR LEU ARG ARG GLU SEQRES 19 E 426 GLN MET PHE VAL ARG HIS LEU PHE ASN ARG ALA GLY THR SEQRES 20 E 426 VAL GLY GLU ASN VAL PRO ASP ASP LEU TYR ILE LYS GLY SEQRES 21 E 426 SER GLY SER THR ALA ASN LEU ALA SER SER ASN TYR PHE SEQRES 22 E 426 PRO THR PRO SER GLY SER MET VAL THR SER ASP ALA GLN SEQRES 23 E 426 ILE PHE ASN LYS PRO TYR TRP LEU GLN ARG ALA GLN GLY SEQRES 24 E 426 HIS ASN ASN GLY ILE CYS TRP GLY ASN GLN LEU PHE VAL SEQRES 25 E 426 THR VAL VAL ASP THR THR ARG SER THR ASN MET SER LEU SEQRES 26 E 426 CYS ALA ALA ILE SER THR SER GLU THR THR TYR LYS ASN SEQRES 27 E 426 THR ASN PHE LYS GLU TYR LEU ARG HIS GLY GLU GLU TYR SEQRES 28 E 426 ASP LEU GLN PHE ILE PHE GLN LEU CYS LYS ILE THR LEU SEQRES 29 E 426 THR ALA ASP VAL MET THR TYR ILE HIS SER MET ASN SER SEQRES 30 E 426 THR ILE LEU GLU ASP TRP ASN GLY GLY SER GLY ALA GLU SEQRES 31 E 426 ASP PRO LEU LYS LYS TYR THR PHE TRP GLU VAL ASN LEU SEQRES 32 E 426 LYS GLU LYS PHE SER ALA ASP LEU ASP GLN PHE PRO LEU SEQRES 33 E 426 GLY ARG LYS PHE LEU LEU GLN ALA GLY LEU SEQRES 1 H 235 GLN VAL THR LEU ARG GLU SER GLY PRO ALA LEU VAL LYS SEQRES 2 H 235 PRO THR GLN THR LEU THR LEU THR CYS THR ILE SER GLY SEQRES 3 H 235 LEU SER LEU THR THR SER GLY VAL CYS VAL SER TRP ILE SEQRES 4 H 235 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 H 235 ILE ASP TRP ASP ASP ASP LYS TYR TYR SER THR SER LEU SEQRES 6 H 235 ARG THR ARG LEU THR ILE SER LYS ASP ILE SER LYS ASN SEQRES 7 H 235 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO VAL ASP SEQRES 8 H 235 THR ALA THR PHE PHE CYS ALA ARG THR ARG CYS THR SER SEQRES 9 H 235 ASN TRP GLY TYR TYR PHE ASP SER TRP GLY ARG GLY THR SEQRES 10 H 235 ARG VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 H 235 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 H 235 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 H 235 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 H 235 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 H 235 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 H 235 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 H 235 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 H 235 GLU PRO LYS SER CYS ASP LYS THR HIS HIS HIS HIS HIS SEQRES 19 H 235 HIS SEQRES 1 L 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 L 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER ALA SEQRES 3 L 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 L 217 GLN VAL PRO GLY ALA ALA PRO LYS LEU LEU ILE PHE VAL SEQRES 5 L 217 TYR SER ASN ARG PRO SER GLY VAL PRO ASP ARG ILE SER SEQRES 6 L 217 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER SEQRES 7 L 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 L 217 SER TYR ASP ASP SER LEU ARG GLY TRP VAL PHE GLY GLY SEQRES 9 L 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 L 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 L 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 L 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 L 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 L 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 L 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 L 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 L 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 M 235 GLN VAL THR LEU ARG GLU SER GLY PRO ALA LEU VAL LYS SEQRES 2 M 235 PRO THR GLN THR LEU THR LEU THR CYS THR ILE SER GLY SEQRES 3 M 235 LEU SER LEU THR THR SER GLY VAL CYS VAL SER TRP ILE SEQRES 4 M 235 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 M 235 ILE ASP TRP ASP ASP ASP LYS TYR TYR SER THR SER LEU SEQRES 6 M 235 ARG THR ARG LEU THR ILE SER LYS ASP ILE SER LYS ASN SEQRES 7 M 235 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO VAL ASP SEQRES 8 M 235 THR ALA THR PHE PHE CYS ALA ARG THR ARG CYS THR SER SEQRES 9 M 235 ASN TRP GLY TYR TYR PHE ASP SER TRP GLY ARG GLY THR SEQRES 10 M 235 ARG VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 M 235 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 M 235 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 M 235 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 M 235 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 M 235 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 M 235 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 M 235 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 M 235 GLU PRO LYS SER CYS ASP LYS THR HIS HIS HIS HIS HIS SEQRES 19 M 235 HIS SEQRES 1 N 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 N 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER ALA SEQRES 3 N 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 N 217 GLN VAL PRO GLY ALA ALA PRO LYS LEU LEU ILE PHE VAL SEQRES 5 N 217 TYR SER ASN ARG PRO SER GLY VAL PRO ASP ARG ILE SER SEQRES 6 N 217 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER SEQRES 7 N 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 N 217 SER TYR ASP ASP SER LEU ARG GLY TRP VAL PHE GLY GLY SEQRES 9 N 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 N 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 N 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 N 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 N 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 N 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 N 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 N 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 N 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 O 235 GLN VAL THR LEU ARG GLU SER GLY PRO ALA LEU VAL LYS SEQRES 2 O 235 PRO THR GLN THR LEU THR LEU THR CYS THR ILE SER GLY SEQRES 3 O 235 LEU SER LEU THR THR SER GLY VAL CYS VAL SER TRP ILE SEQRES 4 O 235 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 O 235 ILE ASP TRP ASP ASP ASP LYS TYR TYR SER THR SER LEU SEQRES 6 O 235 ARG THR ARG LEU THR ILE SER LYS ASP ILE SER LYS ASN SEQRES 7 O 235 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO VAL ASP SEQRES 8 O 235 THR ALA THR PHE PHE CYS ALA ARG THR ARG CYS THR SER SEQRES 9 O 235 ASN TRP GLY TYR TYR PHE ASP SER TRP GLY ARG GLY THR SEQRES 10 O 235 ARG VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 O 235 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 O 235 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 O 235 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 O 235 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 O 235 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 O 235 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 O 235 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 O 235 GLU PRO LYS SER CYS ASP LYS THR HIS HIS HIS HIS HIS SEQRES 19 O 235 HIS SEQRES 1 P 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 P 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER ALA SEQRES 3 P 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 P 217 GLN VAL PRO GLY ALA ALA PRO LYS LEU LEU ILE PHE VAL SEQRES 5 P 217 TYR SER ASN ARG PRO SER GLY VAL PRO ASP ARG ILE SER SEQRES 6 P 217 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER SEQRES 7 P 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 P 217 SER TYR ASP ASP SER LEU ARG GLY TRP VAL PHE GLY GLY SEQRES 9 P 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 P 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 P 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 P 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 P 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 P 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 P 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 P 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 P 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 Q 235 GLN VAL THR LEU ARG GLU SER GLY PRO ALA LEU VAL LYS SEQRES 2 Q 235 PRO THR GLN THR LEU THR LEU THR CYS THR ILE SER GLY SEQRES 3 Q 235 LEU SER LEU THR THR SER GLY VAL CYS VAL SER TRP ILE SEQRES 4 Q 235 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 Q 235 ILE ASP TRP ASP ASP ASP LYS TYR TYR SER THR SER LEU SEQRES 6 Q 235 ARG THR ARG LEU THR ILE SER LYS ASP ILE SER LYS ASN SEQRES 7 Q 235 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO VAL ASP SEQRES 8 Q 235 THR ALA THR PHE PHE CYS ALA ARG THR ARG CYS THR SER SEQRES 9 Q 235 ASN TRP GLY TYR TYR PHE ASP SER TRP GLY ARG GLY THR SEQRES 10 Q 235 ARG VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 Q 235 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 Q 235 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 Q 235 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 Q 235 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 Q 235 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 Q 235 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 Q 235 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 Q 235 GLU PRO LYS SER CYS ASP LYS THR HIS HIS HIS HIS HIS SEQRES 19 Q 235 HIS SEQRES 1 R 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 R 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER ALA SEQRES 3 R 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 R 217 GLN VAL PRO GLY ALA ALA PRO LYS LEU LEU ILE PHE VAL SEQRES 5 R 217 TYR SER ASN ARG PRO SER GLY VAL PRO ASP ARG ILE SER SEQRES 6 R 217 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER SEQRES 7 R 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 R 217 SER TYR ASP ASP SER LEU ARG GLY TRP VAL PHE GLY GLY SEQRES 9 R 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 R 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 R 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 R 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 R 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 R 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 R 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 R 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 R 217 LYS THR VAL ALA PRO THR GLU CYS SER SEQRES 1 S 235 GLN VAL THR LEU ARG GLU SER GLY PRO ALA LEU VAL LYS SEQRES 2 S 235 PRO THR GLN THR LEU THR LEU THR CYS THR ILE SER GLY SEQRES 3 S 235 LEU SER LEU THR THR SER GLY VAL CYS VAL SER TRP ILE SEQRES 4 S 235 ARG GLN PRO PRO GLY LYS ALA LEU GLU TRP LEU ALA LEU SEQRES 5 S 235 ILE ASP TRP ASP ASP ASP LYS TYR TYR SER THR SER LEU SEQRES 6 S 235 ARG THR ARG LEU THR ILE SER LYS ASP ILE SER LYS ASN SEQRES 7 S 235 GLN VAL VAL LEU THR MET THR ASN MET ASP PRO VAL ASP SEQRES 8 S 235 THR ALA THR PHE PHE CYS ALA ARG THR ARG CYS THR SER SEQRES 9 S 235 ASN TRP GLY TYR TYR PHE ASP SER TRP GLY ARG GLY THR SEQRES 10 S 235 ARG VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 S 235 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 S 235 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 S 235 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 S 235 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 S 235 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 S 235 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 S 235 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS ARG VAL SEQRES 18 S 235 GLU PRO LYS SER CYS ASP LYS THR HIS HIS HIS HIS HIS SEQRES 19 S 235 HIS SEQRES 1 T 217 GLN SER VAL LEU THR GLN PRO PRO SER VAL SER GLY ALA SEQRES 2 T 217 PRO GLY GLN ARG VAL THR ILE SER CYS THR GLY SER ALA SEQRES 3 T 217 SER ASN ILE GLY ALA GLY TYR ASP VAL HIS TRP TYR GLN SEQRES 4 T 217 GLN VAL PRO GLY ALA ALA PRO LYS LEU LEU ILE PHE VAL SEQRES 5 T 217 TYR SER ASN ARG PRO SER GLY VAL PRO ASP ARG ILE SER SEQRES 6 T 217 GLY SER LYS SER GLY THR SER ALA SER LEU ALA ILE SER SEQRES 7 T 217 GLY LEU GLN ALA GLU ASP GLU ALA ASP TYR TYR CYS GLN SEQRES 8 T 217 SER TYR ASP ASP SER LEU ARG GLY TRP VAL PHE GLY GLY SEQRES 9 T 217 GLY THR LYS LEU THR VAL LEU GLY GLN PRO LYS ALA ALA SEQRES 10 T 217 PRO SER VAL THR LEU PHE PRO PRO SER SER GLU GLU LEU SEQRES 11 T 217 GLN ALA ASN LYS ALA THR LEU VAL CYS LEU ILE SER ASP SEQRES 12 T 217 PHE TYR PRO GLY ALA VAL THR VAL ALA TRP LYS ALA ASP SEQRES 13 T 217 SER SER PRO VAL LYS ALA GLY VAL GLU THR THR THR PRO SEQRES 14 T 217 SER LYS GLN SER ASN ASN LYS TYR ALA ALA SER SER TYR SEQRES 15 T 217 LEU SER LEU THR PRO GLU GLN TRP LYS SER HIS ARG SER SEQRES 16 T 217 TYR SER CYS GLN VAL THR HIS GLU GLY SER THR VAL GLU SEQRES 17 T 217 LYS THR VAL ALA PRO THR GLU CYS SER HELIX 1 AA1 SER A 37 GLU A 40 5 4 HELIX 2 AA2 ASP A 93 PHE A 97 5 5 HELIX 3 AA3 ASP A 101 TYR A 105 5 5 HELIX 4 AA4 ASP A 223 GLN A 228 1 6 HELIX 5 AA5 PRO A 235 THR A 240 1 6 HELIX 6 AA6 ASP A 247 GLU A 254 1 8 HELIX 7 AA7 PRO A 286 TYR A 290 5 5 HELIX 8 AA8 SER A 294 ASN A 299 5 6 HELIX 9 AA9 ASP A 317 GLN A 319 5 3 HELIX 10 AB1 LYS A 370 THR A 372 5 3 HELIX 11 AB2 THR A 398 ASN A 417 1 20 HELIX 12 AB3 ASP A 452 TYR A 458 5 6 HELIX 13 AB4 ASP A 472 GLN A 475 5 4 HELIX 14 AB5 PHE A 476 ALA A 486 1 11 HELIX 15 AB6 SER B 37 GLU B 40 5 4 HELIX 16 AB7 ASP B 93 PHE B 97 5 5 HELIX 17 AB8 ASP B 101 TYR B 105 5 5 HELIX 18 AB9 ASP B 223 GLN B 228 1 6 HELIX 19 AC1 PRO B 235 THR B 240 1 6 HELIX 20 AC2 ASP B 247 GLU B 254 1 8 HELIX 21 AC3 PRO B 286 TYR B 290 5 5 HELIX 22 AC4 SER B 294 ASN B 299 5 6 HELIX 23 AC5 ASP B 317 GLN B 319 5 3 HELIX 24 AC6 LYS B 370 THR B 372 5 3 HELIX 25 AC7 THR B 398 ASN B 417 1 20 HELIX 26 AC8 ASP B 452 TYR B 458 5 6 HELIX 27 AC9 ASP B 472 GLN B 475 5 4 HELIX 28 AD1 PHE B 476 ALA B 486 1 11 HELIX 29 AD2 SER C 37 GLU C 40 5 4 HELIX 30 AD3 ASP C 93 PHE C 97 5 5 HELIX 31 AD4 ASP C 101 TYR C 105 5 5 HELIX 32 AD5 ASP C 223 GLN C 228 1 6 HELIX 33 AD6 PRO C 235 THR C 240 1 6 HELIX 34 AD7 ASP C 247 GLU C 254 1 8 HELIX 35 AD8 PRO C 286 TYR C 290 5 5 HELIX 36 AD9 SER C 294 ASN C 299 5 6 HELIX 37 AE1 ASP C 317 GLN C 319 5 3 HELIX 38 AE2 LYS C 370 THR C 372 5 3 HELIX 39 AE3 THR C 398 ASN C 417 1 20 HELIX 40 AE4 ASP C 452 TYR C 458 5 6 HELIX 41 AE5 ASP C 472 GLN C 475 5 4 HELIX 42 AE6 PHE C 476 ALA C 486 1 11 HELIX 43 AE7 SER D 37 GLU D 40 5 4 HELIX 44 AE8 ASP D 93 PHE D 97 5 5 HELIX 45 AE9 ASP D 101 TYR D 105 5 5 HELIX 46 AF1 ASP D 223 GLN D 228 1 6 HELIX 47 AF2 PRO D 235 THR D 240 1 6 HELIX 48 AF3 ASP D 247 GLU D 254 1 8 HELIX 49 AF4 PRO D 286 TYR D 290 5 5 HELIX 50 AF5 SER D 294 ASN D 299 5 6 HELIX 51 AF6 ASP D 317 GLN D 319 5 3 HELIX 52 AF7 LYS D 370 THR D 372 5 3 HELIX 53 AF8 THR D 398 ASN D 417 1 20 HELIX 54 AF9 ASP D 452 TYR D 458 5 6 HELIX 55 AG1 ASP D 472 GLN D 475 5 4 HELIX 56 AG2 PHE D 476 ALA D 486 1 11 HELIX 57 AG3 SER E 37 GLU E 40 5 4 HELIX 58 AG4 ASP E 93 PHE E 97 5 5 HELIX 59 AG5 ASP E 101 TYR E 105 5 5 HELIX 60 AG6 ASP E 223 GLN E 228 1 6 HELIX 61 AG7 PRO E 235 THR E 240 1 6 HELIX 62 AG8 ASP E 247 GLU E 254 1 8 HELIX 63 AG9 PRO E 286 TYR E 290 5 5 HELIX 64 AH1 SER E 294 ASN E 299 5 6 HELIX 65 AH2 ASP E 317 GLN E 319 5 3 HELIX 66 AH3 LYS E 370 THR E 372 5 3 HELIX 67 AH4 THR E 398 ASN E 417 1 20 HELIX 68 AH5 ASP E 452 TYR E 458 5 6 HELIX 69 AH6 ASP E 472 GLN E 475 5 4 HELIX 70 AH7 PHE E 476 ALA E 486 1 11 HELIX 71 AH8 LEU H 63 THR H 65 5 3 HELIX 72 AH9 ASP H 83 THR H 87 5 5 HELIX 73 AI1 GLN L 79 GLU L 83 5 5 HELIX 74 AI2 LEU M 63 THR M 65 5 3 HELIX 75 AI3 ASP M 83 THR M 87 5 5 HELIX 76 AI4 GLN N 79 GLU N 83 5 5 HELIX 77 AI5 LEU O 63 THR O 65 5 3 HELIX 78 AI6 ASP O 83 THR O 87 5 5 HELIX 79 AI7 GLN P 79 GLU P 83 5 5 HELIX 80 AI8 LEU Q 63 THR Q 65 5 3 HELIX 81 AI9 ASP Q 83 THR Q 87 5 5 HELIX 82 AJ1 GLN R 79 GLU R 83 5 5 HELIX 83 AJ2 LEU S 63 THR S 65 5 3 HELIX 84 AJ3 ASP S 83 THR S 87 5 5 HELIX 85 AJ4 GLN T 79 GLU T 83 5 5 SHEET 1 AA1 3 VAL A 42 HIS A 50 0 SHEET 2 AA1 3 HIS A 380 THR A 396 -1 O PHE A 390 N TYR A 49 SHEET 3 AA1 3 LEU A 56 GLY A 60 -1 N GLY A 60 O HIS A 380 SHEET 1 AA2 4 VAL A 42 HIS A 50 0 SHEET 2 AA2 4 HIS A 380 THR A 396 -1 O PHE A 390 N TYR A 49 SHEET 3 AA2 4 GLN A 110 ARG A 123 -1 N ALA A 115 O GLN A 391 SHEET 4 AA2 4 TYR A 325 TRP A 326 -1 O TYR A 325 N VAL A 119 SHEET 1 AA3 2 ILE A 66 LYS A 67 0 SHEET 2 AA3 2 ILE A 74 VAL A 76 -1 O LEU A 75 N ILE A 66 SHEET 1 AA4 5 PHE A 262 ARG A 265 0 SHEET 2 AA4 5 GLN A 169 GLY A 174 -1 N ILE A 173 O PHE A 262 SHEET 3 AA4 5 GLN A 342 ASP A 349 -1 O PHE A 344 N GLY A 174 SHEET 4 AA4 5 PHE A 87 HIS A 90 -1 N PHE A 87 O VAL A 345 SHEET 5 AA4 5 TRP A 461 ASN A 464 1 O VAL A 463 N HIS A 90 SHEET 1 AA5 2 SER A 132 LEU A 137 0 SHEET 2 AA5 2 GLU A 159 MET A 163 -1 O GLU A 159 N LEU A 137 SHEET 1 AA6 4 LEU A 202 VAL A 208 0 SHEET 2 AA6 4 ILE A 179 LYS A 185 -1 N GLY A 180 O THR A 207 SHEET 3 AA6 4 CYS A 243 PRO A 246 -1 O TYR A 245 N GLU A 181 SHEET 4 AA6 4 MET A 214 VAL A 215 1 N MET A 214 O LYS A 244 SHEET 1 AA7 2 GLN A 268 MET A 269 0 SHEET 2 AA7 2 VAL E 314 THR E 315 -1 O VAL E 314 N MET A 269 SHEET 1 AA8 2 HIS A 273 ASN A 276 0 SHEET 2 AA8 2 TYR A 305 THR A 308 -1 O THR A 308 N HIS A 273 SHEET 1 AA9 3 THR A 280 VAL A 281 0 SHEET 2 AA9 3 PHE E 374 GLU E 376 1 O GLU E 376 N THR A 280 SHEET 3 AA9 3 ALA E 360 ALA E 361 -1 N ALA E 360 O LYS E 375 SHEET 1 AB1 2 VAL A 314 THR A 315 0 SHEET 2 AB1 2 GLN B 268 MET B 269 -1 O MET B 269 N VAL A 314 SHEET 1 AB2 3 ALA A 360 ALA A 361 0 SHEET 2 AB2 3 PHE A 374 GLU A 376 -1 O LYS A 375 N ALA A 360 SHEET 3 AB2 3 THR B 280 VAL B 281 1 O THR B 280 N GLU A 376 SHEET 1 AB3 3 VAL B 42 HIS B 50 0 SHEET 2 AB3 3 HIS B 380 THR B 396 -1 O PHE B 390 N TYR B 49 SHEET 3 AB3 3 LEU B 56 GLY B 60 -1 N GLY B 60 O HIS B 380 SHEET 1 AB4 4 VAL B 42 HIS B 50 0 SHEET 2 AB4 4 HIS B 380 THR B 396 -1 O PHE B 390 N TYR B 49 SHEET 3 AB4 4 GLN B 110 ARG B 123 -1 N ALA B 115 O GLN B 391 SHEET 4 AB4 4 TYR B 325 TRP B 326 -1 O TYR B 325 N VAL B 119 SHEET 1 AB5 2 ILE B 66 LYS B 67 0 SHEET 2 AB5 2 ILE B 74 VAL B 76 -1 O LEU B 75 N ILE B 66 SHEET 1 AB6 5 PHE B 262 ARG B 265 0 SHEET 2 AB6 5 GLN B 169 GLY B 174 -1 N ILE B 173 O PHE B 262 SHEET 3 AB6 5 GLN B 342 ASP B 349 -1 O PHE B 344 N GLY B 174 SHEET 4 AB6 5 PHE B 87 HIS B 90 -1 N PHE B 87 O VAL B 345 SHEET 5 AB6 5 TRP B 461 ASN B 464 1 O VAL B 463 N HIS B 90 SHEET 1 AB7 2 SER B 132 LEU B 137 0 SHEET 2 AB7 2 GLU B 159 MET B 163 -1 O GLU B 159 N LEU B 137 SHEET 1 AB8 4 LEU B 202 VAL B 208 0 SHEET 2 AB8 4 ILE B 179 LYS B 185 -1 N GLY B 180 O THR B 207 SHEET 3 AB8 4 CYS B 243 PRO B 246 -1 O TYR B 245 N GLU B 181 SHEET 4 AB8 4 MET B 214 VAL B 215 1 N MET B 214 O LYS B 244 SHEET 1 AB9 2 HIS B 273 ASN B 276 0 SHEET 2 AB9 2 TYR B 305 THR B 308 -1 O THR B 308 N HIS B 273 SHEET 1 AC1 2 VAL B 314 THR B 315 0 SHEET 2 AC1 2 GLN C 268 MET C 269 -1 O MET C 269 N VAL B 314 SHEET 1 AC2 3 ALA B 360 ALA B 361 0 SHEET 2 AC2 3 PHE B 374 GLU B 376 -1 O LYS B 375 N ALA B 360 SHEET 3 AC2 3 THR C 280 VAL C 281 1 O THR C 280 N GLU B 376 SHEET 1 AC3 3 VAL C 42 HIS C 50 0 SHEET 2 AC3 3 HIS C 380 THR C 396 -1 O PHE C 390 N TYR C 49 SHEET 3 AC3 3 LEU C 56 GLY C 60 -1 N GLY C 60 O HIS C 380 SHEET 1 AC4 4 VAL C 42 HIS C 50 0 SHEET 2 AC4 4 HIS C 380 THR C 396 -1 O PHE C 390 N TYR C 49 SHEET 3 AC4 4 GLN C 110 ARG C 123 -1 N ALA C 115 O GLN C 391 SHEET 4 AC4 4 TYR C 325 TRP C 326 -1 O TYR C 325 N VAL C 119 SHEET 1 AC5 2 ILE C 66 LYS C 67 0 SHEET 2 AC5 2 ILE C 74 VAL C 76 -1 O LEU C 75 N ILE C 66 SHEET 1 AC6 5 PHE C 262 ARG C 265 0 SHEET 2 AC6 5 GLN C 169 GLY C 174 -1 N ILE C 173 O PHE C 262 SHEET 3 AC6 5 GLN C 342 ASP C 349 -1 O PHE C 344 N GLY C 174 SHEET 4 AC6 5 PHE C 87 HIS C 90 -1 N PHE C 87 O VAL C 345 SHEET 5 AC6 5 TRP C 461 ASN C 464 1 O VAL C 463 N HIS C 90 SHEET 1 AC7 2 SER C 132 LEU C 137 0 SHEET 2 AC7 2 GLU C 159 MET C 163 -1 O GLU C 159 N LEU C 137 SHEET 1 AC8 4 LEU C 202 VAL C 208 0 SHEET 2 AC8 4 ILE C 179 LYS C 185 -1 N GLY C 180 O THR C 207 SHEET 3 AC8 4 CYS C 243 PRO C 246 -1 O TYR C 245 N GLU C 181 SHEET 4 AC8 4 MET C 214 VAL C 215 1 N MET C 214 O LYS C 244 SHEET 1 AC9 2 HIS C 273 ASN C 276 0 SHEET 2 AC9 2 TYR C 305 THR C 308 -1 O THR C 308 N HIS C 273 SHEET 1 AD1 2 VAL C 314 THR C 315 0 SHEET 2 AD1 2 GLN D 268 MET D 269 -1 O MET D 269 N VAL C 314 SHEET 1 AD2 3 ALA C 360 ALA C 361 0 SHEET 2 AD2 3 PHE C 374 GLU C 376 -1 O LYS C 375 N ALA C 360 SHEET 3 AD2 3 THR D 280 VAL D 281 1 O THR D 280 N GLU C 376 SHEET 1 AD3 3 VAL D 42 HIS D 50 0 SHEET 2 AD3 3 HIS D 380 THR D 396 -1 O PHE D 390 N TYR D 49 SHEET 3 AD3 3 LEU D 56 GLY D 60 -1 N GLY D 60 O HIS D 380 SHEET 1 AD4 4 VAL D 42 HIS D 50 0 SHEET 2 AD4 4 HIS D 380 THR D 396 -1 O PHE D 390 N TYR D 49 SHEET 3 AD4 4 GLN D 110 ARG D 123 -1 N ALA D 115 O GLN D 391 SHEET 4 AD4 4 TYR D 325 TRP D 326 -1 O TYR D 325 N VAL D 119 SHEET 1 AD5 2 ILE D 66 LYS D 67 0 SHEET 2 AD5 2 ILE D 74 VAL D 76 -1 O LEU D 75 N ILE D 66 SHEET 1 AD6 5 PHE D 262 ARG D 265 0 SHEET 2 AD6 5 GLN D 169 GLY D 174 -1 N ILE D 173 O PHE D 262 SHEET 3 AD6 5 GLN D 342 ASP D 349 -1 O PHE D 344 N GLY D 174 SHEET 4 AD6 5 PHE D 87 HIS D 90 -1 N PHE D 87 O VAL D 345 SHEET 5 AD6 5 TRP D 461 ASN D 464 1 O VAL D 463 N HIS D 90 SHEET 1 AD7 2 SER D 132 LEU D 137 0 SHEET 2 AD7 2 GLU D 159 MET D 163 -1 O GLU D 159 N LEU D 137 SHEET 1 AD8 4 LEU D 202 VAL D 208 0 SHEET 2 AD8 4 ILE D 179 LYS D 185 -1 N GLY D 180 O THR D 207 SHEET 3 AD8 4 CYS D 243 PRO D 246 -1 O TYR D 245 N GLU D 181 SHEET 4 AD8 4 MET D 214 VAL D 215 1 N MET D 214 O LYS D 244 SHEET 1 AD9 2 HIS D 273 ASN D 276 0 SHEET 2 AD9 2 TYR D 305 THR D 308 -1 O THR D 308 N HIS D 273 SHEET 1 AE1 2 VAL D 314 THR D 315 0 SHEET 2 AE1 2 GLN E 268 MET E 269 -1 O MET E 269 N VAL D 314 SHEET 1 AE2 3 ALA D 360 ALA D 361 0 SHEET 2 AE2 3 PHE D 374 GLU D 376 -1 O LYS D 375 N ALA D 360 SHEET 3 AE2 3 THR E 280 VAL E 281 1 O THR E 280 N GLU D 376 SHEET 1 AE3 3 VAL E 42 HIS E 50 0 SHEET 2 AE3 3 HIS E 380 THR E 396 -1 O PHE E 390 N TYR E 49 SHEET 3 AE3 3 LEU E 56 GLY E 60 -1 N GLY E 60 O HIS E 380 SHEET 1 AE4 4 VAL E 42 HIS E 50 0 SHEET 2 AE4 4 HIS E 380 THR E 396 -1 O PHE E 390 N TYR E 49 SHEET 3 AE4 4 GLN E 110 ARG E 123 -1 N ALA E 115 O GLN E 391 SHEET 4 AE4 4 TYR E 325 TRP E 326 -1 O TYR E 325 N VAL E 119 SHEET 1 AE5 2 ILE E 66 LYS E 67 0 SHEET 2 AE5 2 ILE E 74 VAL E 76 -1 O LEU E 75 N ILE E 66 SHEET 1 AE6 5 PHE E 262 ARG E 265 0 SHEET 2 AE6 5 GLN E 169 GLY E 174 -1 N ILE E 173 O PHE E 262 SHEET 3 AE6 5 GLN E 342 ASP E 349 -1 O PHE E 344 N GLY E 174 SHEET 4 AE6 5 PHE E 87 HIS E 90 -1 N PHE E 87 O VAL E 345 SHEET 5 AE6 5 TRP E 461 ASN E 464 1 O VAL E 463 N HIS E 90 SHEET 1 AE7 2 SER E 132 LEU E 137 0 SHEET 2 AE7 2 GLU E 159 MET E 163 -1 O GLU E 159 N LEU E 137 SHEET 1 AE8 4 LEU E 202 VAL E 208 0 SHEET 2 AE8 4 ILE E 179 LYS E 185 -1 N GLY E 180 O THR E 207 SHEET 3 AE8 4 CYS E 243 PRO E 246 -1 O TYR E 245 N GLU E 181 SHEET 4 AE8 4 MET E 214 VAL E 215 1 N MET E 214 O LYS E 244 SHEET 1 AE9 2 HIS E 273 ASN E 276 0 SHEET 2 AE9 2 TYR E 305 THR E 308 -1 O THR E 308 N HIS E 273 SHEET 1 AF1 4 THR H 3 SER H 7 0 SHEET 2 AF1 4 THR H 17 SER H 25 -1 O THR H 23 N ARG H 5 SHEET 3 AF1 4 GLN H 77 THR H 82A-1 O MET H 82 N LEU H 18 SHEET 4 AF1 4 LEU H 67 ASP H 72 -1 N ASP H 72 O GLN H 77 SHEET 1 AF2 6 LEU H 11 VAL H 12 0 SHEET 2 AF2 6 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AF2 6 ALA H 88 THR H 95 -1 N PHE H 90 O THR H 107 SHEET 4 AF2 6 CYS H 35 GLN H 39 -1 N ILE H 37 O PHE H 91 SHEET 5 AF2 6 GLU H 46 ASP H 52 -1 O LEU H 48 N TRP H 36 SHEET 6 AF2 6 LYS H 57 TYR H 59 -1 O TYR H 58 N LEU H 50 SHEET 1 AF3 4 LEU H 11 VAL H 12 0 SHEET 2 AF3 4 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AF3 4 ALA H 88 THR H 95 -1 N PHE H 90 O THR H 107 SHEET 4 AF3 4 PHE H 100E TRP H 103 -1 O ASP H 101 N ARG H 94 SHEET 1 AF4 5 SER L 9 GLY L 13 0 SHEET 2 AF4 5 THR L 102 VAL L 106 1 O THR L 105 N GLY L 13 SHEET 3 AF4 5 ASP L 85 TYR L 91 -1 N TYR L 86 O THR L 102 SHEET 4 AF4 5 HIS L 34 GLN L 38 -1 N HIS L 34 O GLN L 89 SHEET 5 AF4 5 LYS L 45 ILE L 48 -1 O LEU L 47 N TRP L 35 SHEET 1 AF5 4 SER L 9 GLY L 13 0 SHEET 2 AF5 4 THR L 102 VAL L 106 1 O THR L 105 N GLY L 13 SHEET 3 AF5 4 ASP L 85 TYR L 91 -1 N TYR L 86 O THR L 102 SHEET 4 AF5 4 TRP L 96 PHE L 98 -1 O VAL L 97 N SER L 90 SHEET 1 AF6 3 VAL L 19 THR L 24 0 SHEET 2 AF6 3 SER L 70 ILE L 75 -1 O ILE L 75 N VAL L 19 SHEET 3 AF6 3 ILE L 62 SER L 67 -1 N SER L 67 O SER L 70 SHEET 1 AF7 4 THR M 3 SER M 7 0 SHEET 2 AF7 4 THR M 17 SER M 25 -1 O THR M 23 N ARG M 5 SHEET 3 AF7 4 GLN M 77 THR M 82A-1 O MET M 82 N LEU M 18 SHEET 4 AF7 4 LEU M 67 ASP M 72 -1 N ASP M 72 O GLN M 77 SHEET 1 AF8 6 LEU M 11 VAL M 12 0 SHEET 2 AF8 6 THR M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AF8 6 ALA M 88 THR M 95 -1 N PHE M 90 O THR M 107 SHEET 4 AF8 6 CYS M 35 GLN M 39 -1 N ILE M 37 O PHE M 91 SHEET 5 AF8 6 GLU M 46 ASP M 52 -1 O LEU M 48 N TRP M 36 SHEET 6 AF8 6 LYS M 57 TYR M 59 -1 O TYR M 58 N LEU M 50 SHEET 1 AF9 4 LEU M 11 VAL M 12 0 SHEET 2 AF9 4 THR M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AF9 4 ALA M 88 THR M 95 -1 N PHE M 90 O THR M 107 SHEET 4 AF9 4 PHE M 100E TRP M 103 -1 O ASP M 101 N ARG M 94 SHEET 1 AG1 5 SER N 9 GLY N 13 0 SHEET 2 AG1 5 THR N 102 VAL N 106 1 O THR N 105 N GLY N 13 SHEET 3 AG1 5 ASP N 85 TYR N 91 -1 N TYR N 86 O THR N 102 SHEET 4 AG1 5 HIS N 34 GLN N 38 -1 N HIS N 34 O GLN N 89 SHEET 5 AG1 5 LYS N 45 ILE N 48 -1 O LEU N 47 N TRP N 35 SHEET 1 AG2 4 SER N 9 GLY N 13 0 SHEET 2 AG2 4 THR N 102 VAL N 106 1 O THR N 105 N GLY N 13 SHEET 3 AG2 4 ASP N 85 TYR N 91 -1 N TYR N 86 O THR N 102 SHEET 4 AG2 4 TRP N 96 PHE N 98 -1 O VAL N 97 N SER N 90 SHEET 1 AG3 3 VAL N 19 THR N 24 0 SHEET 2 AG3 3 SER N 70 ILE N 75 -1 O ILE N 75 N VAL N 19 SHEET 3 AG3 3 ILE N 62 SER N 67 -1 N SER N 67 O SER N 70 SHEET 1 AG4 4 THR O 3 SER O 7 0 SHEET 2 AG4 4 THR O 17 SER O 25 -1 O THR O 23 N ARG O 5 SHEET 3 AG4 4 GLN O 77 THR O 82A-1 O MET O 82 N LEU O 18 SHEET 4 AG4 4 LEU O 67 ASP O 72 -1 N ASP O 72 O GLN O 77 SHEET 1 AG5 6 LEU O 11 VAL O 12 0 SHEET 2 AG5 6 THR O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AG5 6 ALA O 88 THR O 95 -1 N PHE O 90 O THR O 107 SHEET 4 AG5 6 CYS O 35 GLN O 39 -1 N ILE O 37 O PHE O 91 SHEET 5 AG5 6 GLU O 46 ASP O 52 -1 O LEU O 48 N TRP O 36 SHEET 6 AG5 6 LYS O 57 TYR O 59 -1 O TYR O 58 N LEU O 50 SHEET 1 AG6 4 LEU O 11 VAL O 12 0 SHEET 2 AG6 4 THR O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AG6 4 ALA O 88 THR O 95 -1 N PHE O 90 O THR O 107 SHEET 4 AG6 4 PHE O 100E TRP O 103 -1 O ASP O 101 N ARG O 94 SHEET 1 AG7 5 SER P 9 GLY P 13 0 SHEET 2 AG7 5 THR P 102 VAL P 106 1 O THR P 105 N GLY P 13 SHEET 3 AG7 5 ASP P 85 TYR P 91 -1 N TYR P 86 O THR P 102 SHEET 4 AG7 5 HIS P 34 GLN P 38 -1 N HIS P 34 O GLN P 89 SHEET 5 AG7 5 LYS P 45 ILE P 48 -1 O LEU P 47 N TRP P 35 SHEET 1 AG8 4 SER P 9 GLY P 13 0 SHEET 2 AG8 4 THR P 102 VAL P 106 1 O THR P 105 N GLY P 13 SHEET 3 AG8 4 ASP P 85 TYR P 91 -1 N TYR P 86 O THR P 102 SHEET 4 AG8 4 TRP P 96 PHE P 98 -1 O VAL P 97 N SER P 90 SHEET 1 AG9 3 VAL P 19 THR P 24 0 SHEET 2 AG9 3 SER P 70 ILE P 75 -1 O ILE P 75 N VAL P 19 SHEET 3 AG9 3 ILE P 62 SER P 67 -1 N SER P 67 O SER P 70 SHEET 1 AH1 4 THR Q 3 SER Q 7 0 SHEET 2 AH1 4 THR Q 17 SER Q 25 -1 O THR Q 23 N ARG Q 5 SHEET 3 AH1 4 GLN Q 77 THR Q 82A-1 O MET Q 82 N LEU Q 18 SHEET 4 AH1 4 LEU Q 67 ASP Q 72 -1 N ASP Q 72 O GLN Q 77 SHEET 1 AH2 6 LEU Q 11 VAL Q 12 0 SHEET 2 AH2 6 THR Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AH2 6 ALA Q 88 THR Q 95 -1 N PHE Q 90 O THR Q 107 SHEET 4 AH2 6 CYS Q 35 GLN Q 39 -1 N ILE Q 37 O PHE Q 91 SHEET 5 AH2 6 GLU Q 46 ASP Q 52 -1 O LEU Q 48 N TRP Q 36 SHEET 6 AH2 6 LYS Q 57 TYR Q 59 -1 O TYR Q 58 N LEU Q 50 SHEET 1 AH3 4 LEU Q 11 VAL Q 12 0 SHEET 2 AH3 4 THR Q 107 VAL Q 111 1 O THR Q 110 N VAL Q 12 SHEET 3 AH3 4 ALA Q 88 THR Q 95 -1 N PHE Q 90 O THR Q 107 SHEET 4 AH3 4 PHE Q 100E TRP Q 103 -1 O ASP Q 101 N ARG Q 94 SHEET 1 AH4 5 SER R 9 GLY R 13 0 SHEET 2 AH4 5 THR R 102 VAL R 106 1 O THR R 105 N GLY R 13 SHEET 3 AH4 5 ASP R 85 TYR R 91 -1 N TYR R 86 O THR R 102 SHEET 4 AH4 5 HIS R 34 GLN R 38 -1 N HIS R 34 O GLN R 89 SHEET 5 AH4 5 LYS R 45 ILE R 48 -1 O LEU R 47 N TRP R 35 SHEET 1 AH5 4 SER R 9 GLY R 13 0 SHEET 2 AH5 4 THR R 102 VAL R 106 1 O THR R 105 N GLY R 13 SHEET 3 AH5 4 ASP R 85 TYR R 91 -1 N TYR R 86 O THR R 102 SHEET 4 AH5 4 TRP R 96 PHE R 98 -1 O VAL R 97 N SER R 90 SHEET 1 AH6 3 VAL R 19 THR R 24 0 SHEET 2 AH6 3 SER R 70 ILE R 75 -1 O ILE R 75 N VAL R 19 SHEET 3 AH6 3 ILE R 62 SER R 67 -1 N SER R 67 O SER R 70 SHEET 1 AH7 4 THR S 3 SER S 7 0 SHEET 2 AH7 4 THR S 17 SER S 25 -1 O THR S 23 N ARG S 5 SHEET 3 AH7 4 GLN S 77 THR S 82A-1 O MET S 82 N LEU S 18 SHEET 4 AH7 4 LEU S 67 ASP S 72 -1 N ASP S 72 O GLN S 77 SHEET 1 AH8 6 LEU S 11 VAL S 12 0 SHEET 2 AH8 6 THR S 107 VAL S 111 1 O THR S 110 N VAL S 12 SHEET 3 AH8 6 ALA S 88 THR S 95 -1 N PHE S 90 O THR S 107 SHEET 4 AH8 6 CYS S 35 GLN S 39 -1 N ILE S 37 O PHE S 91 SHEET 5 AH8 6 GLU S 46 ASP S 52 -1 O LEU S 48 N TRP S 36 SHEET 6 AH8 6 LYS S 57 TYR S 59 -1 O TYR S 58 N LEU S 50 SHEET 1 AH9 4 LEU S 11 VAL S 12 0 SHEET 2 AH9 4 THR S 107 VAL S 111 1 O THR S 110 N VAL S 12 SHEET 3 AH9 4 ALA S 88 THR S 95 -1 N PHE S 90 O THR S 107 SHEET 4 AH9 4 PHE S 100E TRP S 103 -1 O ASP S 101 N ARG S 94 SHEET 1 AI1 5 SER T 9 GLY T 13 0 SHEET 2 AI1 5 THR T 102 VAL T 106 1 O THR T 105 N GLY T 13 SHEET 3 AI1 5 ASP T 85 TYR T 91 -1 N TYR T 86 O THR T 102 SHEET 4 AI1 5 HIS T 34 GLN T 38 -1 N HIS T 34 O GLN T 89 SHEET 5 AI1 5 LYS T 45 ILE T 48 -1 O LEU T 47 N TRP T 35 SHEET 1 AI2 4 SER T 9 GLY T 13 0 SHEET 2 AI2 4 THR T 102 VAL T 106 1 O THR T 105 N GLY T 13 SHEET 3 AI2 4 ASP T 85 TYR T 91 -1 N TYR T 86 O THR T 102 SHEET 4 AI2 4 TRP T 96 PHE T 98 -1 O VAL T 97 N SER T 90 SHEET 1 AI3 3 VAL T 19 THR T 24 0 SHEET 2 AI3 3 SER T 70 ILE T 75 -1 O ILE T 75 N VAL T 19 SHEET 3 AI3 3 ILE T 62 SER T 67 -1 N SER T 67 O SER T 70 SSBOND 1 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 2 CYS H 35 CYS H 97 1555 1555 2.03 SSBOND 3 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 4 CYS M 22 CYS M 92 1555 1555 2.03 SSBOND 5 CYS M 35 CYS M 97 1555 1555 2.03 SSBOND 6 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 7 CYS O 22 CYS O 92 1555 1555 2.03 SSBOND 8 CYS O 35 CYS O 97 1555 1555 2.03 SSBOND 9 CYS P 23 CYS P 88 1555 1555 2.03 SSBOND 10 CYS Q 22 CYS Q 92 1555 1555 2.03 SSBOND 11 CYS Q 35 CYS Q 97 1555 1555 2.03 SSBOND 12 CYS R 23 CYS R 88 1555 1555 2.03 SSBOND 13 CYS S 22 CYS S 92 1555 1555 2.03 SSBOND 14 CYS S 35 CYS S 97 1555 1555 2.03 SSBOND 15 CYS T 23 CYS T 88 1555 1555 2.03 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000