HEADER VIRAL PROTEIN/IMMUNE SYSTEM 18-DEC-24 9ML5 TITLE STRUCTURE OF THE SARS-COV-2 SPIKE 6P IN COMPLEX WITH THE RABBIT M8B-B8 TITLE 2 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: SPIKE HEXAPRO (6P),S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MUTATION: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: M8B-B8 HEAVY CHAIN; COMPND 9 CHAIN: H, M; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: M8B-B8 LIGHT CHAIN; COMPND 13 CHAIN: L, N; COMPND 14 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_TAXID: 2697049; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; SOURCE 11 ORGANISM_COMMON: RABBIT; SOURCE 12 ORGANISM_TAXID: 9986; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 MOL_ID: 3; SOURCE 17 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; SOURCE 18 ORGANISM_COMMON: RABBIT; SOURCE 19 ORGANISM_TAXID: 9986; SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 21 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS IMMUNE SYSTEM, NEUTRALIZING ANTIBODY, IMMUNE SYSTEM-VIRAL PROTEIN KEYWDS 2 COMPLEX, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR C.FAN,P.J.BJORKMAN REVDAT 1 04-JUN-25 9ML5 0 JRNL AUTH C.FAN,J.R.KEEFFE,K.E.MALECEK,A.A.COHEN,A.P.WEST JR., JRNL AUTH 2 V.A.BAHARANI,A.V.RORICK,H.GAO,P.N.P.GNANAPRAGASAM,S.RHO, JRNL AUTH 3 J.ALVAREZ,L.N.SEGOVIA,T.HATZIIOANNOU,P.D.BIENIASZ, JRNL AUTH 4 P.J.BJORKMAN JRNL TITL CROSS-REACTIVE SARBECOVIRUS ANTIBODIES INDUCED BY MOSAIC RBD JRNL TITL 2 NANOPARTICLES. JRNL REF PROC.NATL.ACAD.SCI.USA V. 122 37122 2025 JRNL REFN ESSN 1091-6490 JRNL PMID 40402246 JRNL DOI 10.1073/PNAS.2501637122 REMARK 2 REMARK 2 RESOLUTION. 3.40 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, SERIALEM, CRYOSPARC, UCSF REMARK 3 CHIMERA, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 7UZD REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : 90.000 REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.400 REMARK 3 NUMBER OF PARTICLES : 148375 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9ML5 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1000290164. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV-2 SPIKE 6P IN COMPLEX REMARK 245 WITH M8B-B8 FAB; SEVERE ACUTE REMARK 245 RESPIRATORY SYNDROME REMARK 245 CORONAVIRUS 2 SPIKE REMARK 245 GLYCOPROTEIN; M8B-B8 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 2.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : STABILIZED WITH HEXAPROLINE REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 2634 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TALOS ARCTICA REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 45000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEPTAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, H, L, M, N, D, E, F, REMARK 350 AND CHAINS: G, I, J, K, O, P REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 PHE A 2 REMARK 465 VAL A 3 REMARK 465 PHE A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 PRO A 9 REMARK 465 LEU A 10 REMARK 465 VAL A 11 REMARK 465 SER A 12 REMARK 465 SER A 13 REMARK 465 GLN A 14 REMARK 465 CYS A 15 REMARK 465 VAL A 16 REMARK 465 ASN A 17 REMARK 465 LEU A 18 REMARK 465 THR A 19 REMARK 465 THR A 20 REMARK 465 ARG A 21 REMARK 465 THR A 22 REMARK 465 GLN A 23 REMARK 465 LEU A 24 REMARK 465 PRO A 25 REMARK 465 PRO A 26 REMARK 465 VAL A 70 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 76 REMARK 465 LYS A 77 REMARK 465 TYR A 144 REMARK 465 TYR A 145 REMARK 465 HIS A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 MET A 153 REMARK 465 GLU A 154 REMARK 465 SER A 155 REMARK 465 GLU A 156 REMARK 465 PHE A 157 REMARK 465 ARG A 158 REMARK 465 VAL A 159 REMARK 465 TYR A 160 REMARK 465 SER A 161 REMARK 465 SER A 162 REMARK 465 ALA A 163 REMARK 465 ASN A 164 REMARK 465 GLN A 173 REMARK 465 PRO A 174 REMARK 465 PHE A 175 REMARK 465 LEU A 176 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLN A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 ALA A 262 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 GLN A 680 REMARK 465 THR A 681 REMARK 465 ASN A 682 REMARK 465 SER A 683 REMARK 465 PRO A 684 REMARK 465 ALA A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 TYR A 1209 REMARK 465 ILE A 1210 REMARK 465 LYS A 1211 REMARK 465 TRP A 1212 REMARK 465 PRO A 1213 REMARK 465 SER A 1214 REMARK 465 GLY A 1215 REMARK 465 ARG A 1216 REMARK 465 LEU A 1217 REMARK 465 VAL A 1218 REMARK 465 PRO A 1219 REMARK 465 ARG A 1220 REMARK 465 GLY A 1221 REMARK 465 SER A 1222 REMARK 465 PRO A 1223 REMARK 465 GLY A 1224 REMARK 465 SER A 1225 REMARK 465 GLY A 1226 REMARK 465 TYR A 1227 REMARK 465 ILE A 1228 REMARK 465 PRO A 1229 REMARK 465 GLU A 1230 REMARK 465 ALA A 1231 REMARK 465 PRO A 1232 REMARK 465 ARG A 1233 REMARK 465 ASP A 1234 REMARK 465 GLY A 1235 REMARK 465 GLN A 1236 REMARK 465 ALA A 1237 REMARK 465 TYR A 1238 REMARK 465 VAL A 1239 REMARK 465 ARG A 1240 REMARK 465 LYS A 1241 REMARK 465 ASP A 1242 REMARK 465 GLY A 1243 REMARK 465 GLU A 1244 REMARK 465 TRP A 1245 REMARK 465 VAL A 1246 REMARK 465 LEU A 1247 REMARK 465 LEU A 1248 REMARK 465 SER A 1249 REMARK 465 THR A 1250 REMARK 465 PHE A 1251 REMARK 465 LEU A 1252 REMARK 465 GLY A 1253 REMARK 465 HIS A 1254 REMARK 465 HIS A 1255 REMARK 465 HIS A 1256 REMARK 465 HIS A 1257 REMARK 465 HIS A 1258 REMARK 465 HIS A 1259 REMARK 465 MET B 1 REMARK 465 PHE B 2 REMARK 465 VAL B 3 REMARK 465 PHE B 4 REMARK 465 LEU B 5 REMARK 465 VAL B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 PRO B 9 REMARK 465 LEU B 10 REMARK 465 VAL B 11 REMARK 465 SER B 12 REMARK 465 SER B 13 REMARK 465 GLN B 14 REMARK 465 CYS B 15 REMARK 465 VAL B 16 REMARK 465 ASN B 17 REMARK 465 LEU B 18 REMARK 465 THR B 19 REMARK 465 THR B 20 REMARK 465 ARG B 21 REMARK 465 THR B 22 REMARK 465 GLN B 23 REMARK 465 LEU B 24 REMARK 465 PRO B 25 REMARK 465 PRO B 26 REMARK 465 VAL B 70 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 THR B 76 REMARK 465 LYS B 77 REMARK 465 TYR B 144 REMARK 465 TYR B 145 REMARK 465 HIS B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASN B 149 REMARK 465 LYS B 150 REMARK 465 SER B 151 REMARK 465 TRP B 152 REMARK 465 MET B 153 REMARK 465 GLU B 154 REMARK 465 SER B 155 REMARK 465 GLU B 156 REMARK 465 PHE B 157 REMARK 465 ARG B 158 REMARK 465 VAL B 159 REMARK 465 TYR B 160 REMARK 465 SER B 161 REMARK 465 SER B 162 REMARK 465 ALA B 163 REMARK 465 ASN B 164 REMARK 465 GLN B 173 REMARK 465 PRO B 174 REMARK 465 PHE B 175 REMARK 465 LEU B 176 REMARK 465 MET B 177 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLN B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 ARG B 246 REMARK 465 SER B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 GLY B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 SER B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 TRP B 258 REMARK 465 THR B 259 REMARK 465 ALA B 260 REMARK 465 GLY B 261 REMARK 465 ALA B 262 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 GLN B 680 REMARK 465 THR B 681 REMARK 465 ASN B 682 REMARK 465 SER B 683 REMARK 465 PRO B 684 REMARK 465 ALA B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 CYS B 851 REMARK 465 ALA B 852 REMARK 465 GLN B 853 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 TYR B 1209 REMARK 465 ILE B 1210 REMARK 465 LYS B 1211 REMARK 465 TRP B 1212 REMARK 465 PRO B 1213 REMARK 465 SER B 1214 REMARK 465 GLY B 1215 REMARK 465 ARG B 1216 REMARK 465 LEU B 1217 REMARK 465 VAL B 1218 REMARK 465 PRO B 1219 REMARK 465 ARG B 1220 REMARK 465 GLY B 1221 REMARK 465 SER B 1222 REMARK 465 PRO B 1223 REMARK 465 GLY B 1224 REMARK 465 SER B 1225 REMARK 465 GLY B 1226 REMARK 465 TYR B 1227 REMARK 465 ILE B 1228 REMARK 465 PRO B 1229 REMARK 465 GLU B 1230 REMARK 465 ALA B 1231 REMARK 465 PRO B 1232 REMARK 465 ARG B 1233 REMARK 465 ASP B 1234 REMARK 465 GLY B 1235 REMARK 465 GLN B 1236 REMARK 465 ALA B 1237 REMARK 465 TYR B 1238 REMARK 465 VAL B 1239 REMARK 465 ARG B 1240 REMARK 465 LYS B 1241 REMARK 465 ASP B 1242 REMARK 465 GLY B 1243 REMARK 465 GLU B 1244 REMARK 465 TRP B 1245 REMARK 465 VAL B 1246 REMARK 465 LEU B 1247 REMARK 465 LEU B 1248 REMARK 465 SER B 1249 REMARK 465 THR B 1250 REMARK 465 PHE B 1251 REMARK 465 LEU B 1252 REMARK 465 GLY B 1253 REMARK 465 HIS B 1254 REMARK 465 HIS B 1255 REMARK 465 HIS B 1256 REMARK 465 HIS B 1257 REMARK 465 HIS B 1258 REMARK 465 HIS B 1259 REMARK 465 MET C 1 REMARK 465 PHE C 2 REMARK 465 VAL C 3 REMARK 465 PHE C 4 REMARK 465 LEU C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 PRO C 9 REMARK 465 LEU C 10 REMARK 465 VAL C 11 REMARK 465 SER C 12 REMARK 465 SER C 13 REMARK 465 GLN C 14 REMARK 465 CYS C 15 REMARK 465 VAL C 16 REMARK 465 ASN C 17 REMARK 465 LEU C 18 REMARK 465 THR C 19 REMARK 465 THR C 20 REMARK 465 ARG C 21 REMARK 465 THR C 22 REMARK 465 GLN C 23 REMARK 465 LEU C 24 REMARK 465 PRO C 25 REMARK 465 PRO C 26 REMARK 465 VAL C 70 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 76 REMARK 465 LYS C 77 REMARK 465 TYR C 144 REMARK 465 TYR C 145 REMARK 465 HIS C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 MET C 153 REMARK 465 GLU C 154 REMARK 465 SER C 155 REMARK 465 GLU C 156 REMARK 465 PHE C 157 REMARK 465 ARG C 158 REMARK 465 VAL C 159 REMARK 465 TYR C 160 REMARK 465 SER C 161 REMARK 465 SER C 162 REMARK 465 ALA C 163 REMARK 465 ASN C 164 REMARK 465 GLN C 173 REMARK 465 PRO C 174 REMARK 465 PHE C 175 REMARK 465 LEU C 176 REMARK 465 MET C 177 REMARK 465 ASP C 178 REMARK 465 LEU C 179 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLN C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 GLY C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 GLY C 261 REMARK 465 ALA C 262 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 GLN C 680 REMARK 465 THR C 681 REMARK 465 ASN C 682 REMARK 465 SER C 683 REMARK 465 PRO C 684 REMARK 465 ALA C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 CYS C 851 REMARK 465 ALA C 852 REMARK 465 GLN C 853 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 TYR C 1209 REMARK 465 ILE C 1210 REMARK 465 LYS C 1211 REMARK 465 TRP C 1212 REMARK 465 PRO C 1213 REMARK 465 SER C 1214 REMARK 465 GLY C 1215 REMARK 465 ARG C 1216 REMARK 465 LEU C 1217 REMARK 465 VAL C 1218 REMARK 465 PRO C 1219 REMARK 465 ARG C 1220 REMARK 465 GLY C 1221 REMARK 465 SER C 1222 REMARK 465 PRO C 1223 REMARK 465 GLY C 1224 REMARK 465 SER C 1225 REMARK 465 GLY C 1226 REMARK 465 TYR C 1227 REMARK 465 ILE C 1228 REMARK 465 PRO C 1229 REMARK 465 GLU C 1230 REMARK 465 ALA C 1231 REMARK 465 PRO C 1232 REMARK 465 ARG C 1233 REMARK 465 ASP C 1234 REMARK 465 GLY C 1235 REMARK 465 GLN C 1236 REMARK 465 ALA C 1237 REMARK 465 TYR C 1238 REMARK 465 VAL C 1239 REMARK 465 ARG C 1240 REMARK 465 LYS C 1241 REMARK 465 ASP C 1242 REMARK 465 GLY C 1243 REMARK 465 GLU C 1244 REMARK 465 TRP C 1245 REMARK 465 VAL C 1246 REMARK 465 LEU C 1247 REMARK 465 LEU C 1248 REMARK 465 SER C 1249 REMARK 465 THR C 1250 REMARK 465 PHE C 1251 REMARK 465 LEU C 1252 REMARK 465 GLY C 1253 REMARK 465 HIS C 1254 REMARK 465 HIS C 1255 REMARK 465 HIS C 1256 REMARK 465 HIS C 1257 REMARK 465 HIS C 1258 REMARK 465 HIS C 1259 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 ALA L 0 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 ALA M 114 REMARK 465 SER M 115 REMARK 465 THR M 116 REMARK 465 LYS M 117 REMARK 465 GLY M 118 REMARK 465 PRO M 119 REMARK 465 SER M 120 REMARK 465 VAL M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 LEU M 124 REMARK 465 ALA M 125 REMARK 465 PRO M 126 REMARK 465 SER M 127 REMARK 465 SER M 128 REMARK 465 LYS M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 SER M 132 REMARK 465 GLY M 133 REMARK 465 GLY M 134 REMARK 465 THR M 135 REMARK 465 ALA M 136 REMARK 465 ALA M 137 REMARK 465 LEU M 138 REMARK 465 GLY M 139 REMARK 465 CYS M 140 REMARK 465 LEU M 141 REMARK 465 VAL M 142 REMARK 465 LYS M 143 REMARK 465 ASP M 144 REMARK 465 TYR M 145 REMARK 465 PHE M 146 REMARK 465 PRO M 147 REMARK 465 GLU M 148 REMARK 465 PRO M 149 REMARK 465 VAL M 150 REMARK 465 THR M 151 REMARK 465 VAL M 152 REMARK 465 SER M 153 REMARK 465 TRP M 154 REMARK 465 ASN M 155 REMARK 465 SER M 156 REMARK 465 GLY M 157 REMARK 465 ALA M 158 REMARK 465 LEU M 159 REMARK 465 THR M 160 REMARK 465 SER M 161 REMARK 465 GLY M 162 REMARK 465 VAL M 163 REMARK 465 HIS M 164 REMARK 465 THR M 165 REMARK 465 PHE M 166 REMARK 465 PRO M 167 REMARK 465 ALA M 168 REMARK 465 VAL M 169 REMARK 465 LEU M 170 REMARK 465 GLN M 171 REMARK 465 SER M 172 REMARK 465 SER M 173 REMARK 465 GLY M 174 REMARK 465 LEU M 175 REMARK 465 TYR M 176 REMARK 465 SER M 177 REMARK 465 LEU M 178 REMARK 465 SER M 179 REMARK 465 SER M 180 REMARK 465 VAL M 181 REMARK 465 VAL M 182 REMARK 465 THR M 183 REMARK 465 VAL M 184 REMARK 465 PRO M 185 REMARK 465 SER M 186 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 LEU M 189 REMARK 465 GLY M 190 REMARK 465 THR M 191 REMARK 465 GLN M 192 REMARK 465 THR M 193 REMARK 465 TYR M 194 REMARK 465 ILE M 195 REMARK 465 CYS M 196 REMARK 465 ASN M 197 REMARK 465 VAL M 198 REMARK 465 ASN M 199 REMARK 465 HIS M 200 REMARK 465 LYS M 201 REMARK 465 PRO M 202 REMARK 465 SER M 203 REMARK 465 ASN M 204 REMARK 465 THR M 205 REMARK 465 LYS M 206 REMARK 465 VAL M 207 REMARK 465 ASP M 208 REMARK 465 LYS M 209 REMARK 465 ARG M 210 REMARK 465 VAL M 211 REMARK 465 GLU M 212 REMARK 465 PRO M 213 REMARK 465 LYS M 214 REMARK 465 SER M 215 REMARK 465 CYS M 216 REMARK 465 ASP M 217 REMARK 465 LYS M 218 REMARK 465 ALA N 0 REMARK 465 ARG N 108 REMARK 465 THR N 109 REMARK 465 VAL N 110 REMARK 465 ALA N 111 REMARK 465 ALA N 112 REMARK 465 PRO N 113 REMARK 465 SER N 114 REMARK 465 VAL N 115 REMARK 465 PHE N 116 REMARK 465 ILE N 117 REMARK 465 PHE N 118 REMARK 465 PRO N 119 REMARK 465 PRO N 120 REMARK 465 SER N 121 REMARK 465 ASP N 122 REMARK 465 GLU N 123 REMARK 465 GLN N 124 REMARK 465 LEU N 125 REMARK 465 LYS N 126 REMARK 465 SER N 127 REMARK 465 GLY N 128 REMARK 465 THR N 129 REMARK 465 ALA N 130 REMARK 465 SER N 131 REMARK 465 VAL N 132 REMARK 465 VAL N 133 REMARK 465 CYS N 134 REMARK 465 LEU N 135 REMARK 465 LEU N 136 REMARK 465 ASN N 137 REMARK 465 ASN N 138 REMARK 465 PHE N 139 REMARK 465 TYR N 140 REMARK 465 PRO N 141 REMARK 465 ARG N 142 REMARK 465 GLU N 143 REMARK 465 ALA N 144 REMARK 465 LYS N 145 REMARK 465 VAL N 146 REMARK 465 GLN N 147 REMARK 465 TRP N 148 REMARK 465 LYS N 149 REMARK 465 VAL N 150 REMARK 465 ASP N 151 REMARK 465 ASN N 152 REMARK 465 ALA N 153 REMARK 465 LEU N 154 REMARK 465 GLN N 155 REMARK 465 SER N 156 REMARK 465 GLY N 157 REMARK 465 ASN N 158 REMARK 465 SER N 159 REMARK 465 GLN N 160 REMARK 465 GLU N 161 REMARK 465 SER N 162 REMARK 465 VAL N 163 REMARK 465 THR N 164 REMARK 465 GLU N 165 REMARK 465 GLN N 166 REMARK 465 ASP N 167 REMARK 465 SER N 168 REMARK 465 LYS N 169 REMARK 465 ASP N 170 REMARK 465 SER N 171 REMARK 465 THR N 172 REMARK 465 TYR N 173 REMARK 465 SER N 174 REMARK 465 LEU N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 THR N 178 REMARK 465 LEU N 179 REMARK 465 THR N 180 REMARK 465 LEU N 181 REMARK 465 SER N 182 REMARK 465 LYS N 183 REMARK 465 ALA N 184 REMARK 465 ASP N 185 REMARK 465 TYR N 186 REMARK 465 GLU N 187 REMARK 465 LYS N 188 REMARK 465 HIS N 189 REMARK 465 LYS N 190 REMARK 465 VAL N 191 REMARK 465 TYR N 192 REMARK 465 ALA N 193 REMARK 465 CYS N 194 REMARK 465 GLU N 195 REMARK 465 VAL N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 GLN N 199 REMARK 465 GLY N 200 REMARK 465 LEU N 201 REMARK 465 SER N 202 REMARK 465 SER N 203 REMARK 465 PRO N 204 REMARK 465 VAL N 205 REMARK 465 THR N 206 REMARK 465 LYS N 207 REMARK 465 SER N 208 REMARK 465 PHE N 209 REMARK 465 ASN N 210 REMARK 465 ARG N 211 REMARK 465 GLY N 212 REMARK 465 GLU N 213 REMARK 465 CYS N 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LEU A 110 29.43 48.21 REMARK 500 SER A 112 -2.31 68.38 REMARK 500 ALA A 292 13.23 -140.04 REMARK 500 GLU A 406 -1.99 68.78 REMARK 500 THR A 478 71.92 42.83 REMARK 500 THR A 547 62.59 39.45 REMARK 500 THR A 638 -124.88 51.75 REMARK 500 ILE A 666 -57.60 -123.60 REMARK 500 SER A 758 32.22 -143.13 REMARK 500 LEU A 945 48.85 -83.60 REMARK 500 ARG A 983 -7.95 72.21 REMARK 500 THR A1117 -9.27 -58.64 REMARK 500 THR B 33 -9.89 -140.50 REMARK 500 ASN B 280 -167.13 -79.71 REMARK 500 PRO B 337 45.29 -79.51 REMARK 500 GLU B 406 26.83 46.13 REMARK 500 ASN B 422 -166.67 -126.06 REMARK 500 ILE B 666 -58.50 -120.33 REMARK 500 SER B 758 24.68 -143.05 REMARK 500 ARG B 983 48.07 38.96 REMARK 500 THR C 33 15.90 -141.90 REMARK 500 ASP C 88 -4.68 75.78 REMARK 500 ARG C 102 -53.78 -120.48 REMARK 500 ASP C 111 29.23 -140.67 REMARK 500 GLU C 406 7.78 56.26 REMARK 500 ASN C 422 -166.88 -129.30 REMARK 500 THR C 478 74.46 44.56 REMARK 500 LEU C 518 -169.88 -128.70 REMARK 500 ASN C 544 51.14 39.99 REMARK 500 CYS C 617 31.67 -92.91 REMARK 500 ILE C 666 -60.84 -107.12 REMARK 500 LEU C 945 49.11 -84.97 REMARK 500 CYS C1043 75.75 -101.43 REMARK 500 SER C1123 117.07 -160.46 REMARK 500 SER H 28 -0.66 68.27 REMARK 500 SER H 56 -4.95 69.22 REMARK 500 THR H 57 -137.18 43.44 REMARK 500 THR H 61 -2.98 63.94 REMARK 500 SER H 73 -114.95 59.21 REMARK 500 SER H 74 -139.79 51.38 REMARK 500 TYR M 33 51.29 -92.96 REMARK 500 ILE M 48 -59.43 -121.62 REMARK 500 CYS M 50 -169.56 -127.46 REMARK 500 SER M 56 -7.22 71.98 REMARK 500 THR M 57 -134.12 47.78 REMARK 500 LYS M 64 -124.17 61.69 REMARK 500 SER M 73 -121.74 58.85 REMARK 500 SER M 74 -130.94 53.21 REMARK 500 ALA N 14 -60.79 -94.22 REMARK 500 ASN N 31 -3.52 69.39 REMARK 500 REMARK 500 THIS ENTRY HAS 52 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-48348 RELATED DB: EMDB REMARK 900 STRUCTURE OF THE SARS-COV-2 SPIKE 6P IN COMPLEX WITH THE RABBIT M8B- REMARK 900 B8 FAB DBREF 9ML5 A 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9ML5 B 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9ML5 C 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9ML5 H 1 218 PDB 9ML5 9ML5 1 218 DBREF 9ML5 L 0 214 PDB 9ML5 9ML5 0 214 DBREF 9ML5 M 1 218 PDB 9ML5 9ML5 1 218 DBREF 9ML5 N 0 214 PDB 9ML5 9ML5 0 214 SEQADV 9ML5 A UNP P0DTC2 ARG 682 DELETION SEQADV 9ML5 A UNP P0DTC2 ARG 683 DELETION SEQADV 9ML5 A UNP P0DTC2 ARG 685 DELETION SEQADV 9ML5 PRO A 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9ML5 PRO A 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9ML5 PRO A 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9ML5 PRO A 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9ML5 PRO A 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9ML5 PRO A 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9ML5 SER A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TYR A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ILE A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLU A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ALA A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ASP A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLN A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ALA A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TYR A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LYS A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ASP A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLU A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TRP A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 THR A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PHE A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 B UNP P0DTC2 ARG 682 DELETION SEQADV 9ML5 B UNP P0DTC2 ARG 683 DELETION SEQADV 9ML5 B UNP P0DTC2 ARG 685 DELETION SEQADV 9ML5 PRO B 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9ML5 PRO B 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9ML5 PRO B 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9ML5 PRO B 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9ML5 PRO B 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9ML5 PRO B 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9ML5 SER B 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY B 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG B 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU B 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL B 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO B 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG B 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY B 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER B 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO B 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY B 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER B 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY B 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TYR B 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ILE B 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO B 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLU B 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ALA B 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO B 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG B 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ASP B 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY B 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLN B 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ALA B 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TYR B 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL B 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG B 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LYS B 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ASP B 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY B 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLU B 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TRP B 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL B 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU B 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU B 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER B 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 THR B 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PHE B 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU B 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY B 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS B 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS B 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS B 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS B 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS B 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS B 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 C UNP P0DTC2 ARG 682 DELETION SEQADV 9ML5 C UNP P0DTC2 ARG 683 DELETION SEQADV 9ML5 C UNP P0DTC2 ARG 685 DELETION SEQADV 9ML5 PRO C 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9ML5 PRO C 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9ML5 PRO C 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9ML5 PRO C 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9ML5 PRO C 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9ML5 PRO C 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9ML5 SER C 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY C 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG C 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU C 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL C 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO C 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG C 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY C 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER C 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO C 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY C 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER C 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY C 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TYR C 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ILE C 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO C 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLU C 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ALA C 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PRO C 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG C 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ASP C 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY C 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLN C 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ALA C 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TYR C 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL C 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ARG C 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LYS C 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 ASP C 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY C 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLU C 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 TRP C 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 VAL C 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU C 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU C 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 SER C 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 THR C 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 PHE C 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 LEU C 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 GLY C 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS C 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS C 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS C 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS C 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS C 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML5 HIS C 1259 UNP P0DTC2 EXPRESSION TAG SEQRES 1 A 1256 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 A 1256 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 A 1256 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 A 1256 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 A 1256 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 A 1256 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 A 1256 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 A 1256 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 A 1256 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 A 1256 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 A 1256 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 A 1256 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 A 1256 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 A 1256 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 A 1256 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 A 1256 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 A 1256 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 A 1256 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 A 1256 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 A 1256 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 A 1256 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 A 1256 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 A 1256 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 A 1256 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 A 1256 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 A 1256 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 A 1256 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 A 1256 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 A 1256 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 A 1256 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 A 1256 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 A 1256 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 A 1256 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 A 1256 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 A 1256 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 A 1256 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 A 1256 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 A 1256 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 A 1256 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 A 1256 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 A 1256 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 A 1256 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 A 1256 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 A 1256 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 A 1256 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 A 1256 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 A 1256 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 A 1256 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 A 1256 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 A 1256 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 A 1256 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 A 1256 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 A 1256 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 A 1256 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 A 1256 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 A 1256 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 A 1256 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 A 1256 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 A 1256 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 A 1256 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 A 1256 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 A 1256 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 A 1256 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 A 1256 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 A 1256 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 A 1256 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 A 1256 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 A 1256 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 A 1256 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 A 1256 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 A 1256 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 A 1256 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 A 1256 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 A 1256 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 A 1256 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 A 1256 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 A 1256 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 A 1256 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 A 1256 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 A 1256 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 A 1256 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 A 1256 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 A 1256 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 A 1256 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 A 1256 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 A 1256 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 A 1256 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 A 1256 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 A 1256 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 A 1256 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 A 1256 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 A 1256 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 A 1256 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 A 1256 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 A 1256 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 A 1256 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 A 1256 LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 B 1256 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 B 1256 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 B 1256 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 B 1256 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 B 1256 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 B 1256 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 B 1256 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 B 1256 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 B 1256 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 B 1256 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 B 1256 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 B 1256 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 B 1256 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 B 1256 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 B 1256 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 B 1256 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 B 1256 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 B 1256 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 B 1256 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 B 1256 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 B 1256 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 B 1256 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 B 1256 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 B 1256 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 B 1256 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 B 1256 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 B 1256 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 B 1256 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 B 1256 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 B 1256 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 B 1256 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 B 1256 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 B 1256 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 B 1256 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 B 1256 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 B 1256 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 B 1256 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 B 1256 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 B 1256 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 B 1256 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 B 1256 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 B 1256 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 B 1256 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 B 1256 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 B 1256 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 B 1256 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 B 1256 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 B 1256 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 B 1256 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 B 1256 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 B 1256 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 B 1256 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 B 1256 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 B 1256 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 B 1256 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 B 1256 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 B 1256 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 B 1256 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 B 1256 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 B 1256 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 B 1256 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 B 1256 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 B 1256 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 B 1256 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 B 1256 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 B 1256 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 B 1256 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 B 1256 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 B 1256 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 B 1256 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 B 1256 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 B 1256 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 B 1256 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 B 1256 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 B 1256 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 B 1256 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 B 1256 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 B 1256 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 B 1256 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 B 1256 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 B 1256 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 B 1256 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 B 1256 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 B 1256 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 B 1256 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 B 1256 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 B 1256 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 B 1256 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 B 1256 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 B 1256 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 B 1256 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 B 1256 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 B 1256 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 B 1256 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 B 1256 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 B 1256 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 B 1256 LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 C 1256 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 C 1256 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 C 1256 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 C 1256 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 C 1256 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 C 1256 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 C 1256 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 C 1256 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 C 1256 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 C 1256 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 C 1256 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 C 1256 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 C 1256 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 C 1256 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 C 1256 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 C 1256 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 C 1256 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 C 1256 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 C 1256 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 C 1256 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 C 1256 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 C 1256 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 C 1256 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 C 1256 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 C 1256 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 C 1256 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 C 1256 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 C 1256 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 C 1256 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 C 1256 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 C 1256 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 C 1256 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 C 1256 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 C 1256 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 C 1256 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 C 1256 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 C 1256 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 C 1256 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 C 1256 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 C 1256 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 C 1256 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 C 1256 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 C 1256 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 C 1256 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 C 1256 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 C 1256 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 C 1256 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 C 1256 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 C 1256 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 C 1256 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 C 1256 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 C 1256 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 C 1256 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 C 1256 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 C 1256 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 C 1256 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 C 1256 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 C 1256 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 C 1256 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 C 1256 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 C 1256 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 C 1256 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 C 1256 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 C 1256 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 C 1256 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 C 1256 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 C 1256 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 C 1256 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 C 1256 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 C 1256 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 C 1256 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 C 1256 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 C 1256 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 C 1256 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 C 1256 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 C 1256 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 C 1256 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 C 1256 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 C 1256 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 C 1256 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 C 1256 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 C 1256 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 C 1256 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 C 1256 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 C 1256 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 C 1256 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 C 1256 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 C 1256 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 C 1256 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 C 1256 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 C 1256 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 C 1256 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 C 1256 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 C 1256 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 C 1256 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 C 1256 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 C 1256 LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 H 223 GLN GLU GLN LEU GLU GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 H 223 PRO GLU GLY SER LEU THR LEU THR CYS THR ALA SER GLY SEQRES 3 H 223 PHE SER PHE SER SER SER TYR TRP ILE CYS TRP VAL ARG SEQRES 4 H 223 GLN ALA PRO GLY LYS GLY LEU GLU TRP ILE GLY CYS ILE SEQRES 5 H 223 TYR THR GLY ASP GLY SER THR TYR TYR ALA THR TRP ALA SEQRES 6 H 223 LYS GLY ARG PHE THR ILE SER LYS ALA SER SER THR THR SEQRES 7 H 223 VAL THR LEU GLN MET THR SER LEU THR ALA ALA ASP THR SEQRES 8 H 223 ALA THR TYR PHE CYS THR ARG GLU GLY GLY TRP TYR ASP SEQRES 9 H 223 LEU ASN LEU TRP GLY PRO GLY THR LEU VAL THR VAL SER SEQRES 10 H 223 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11 H 223 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12 H 223 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13 H 223 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14 H 223 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15 H 223 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16 H 223 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17 H 223 ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 18 H 223 ASP LYS SEQRES 1 L 219 ALA ASP ILE VAL MET THR GLN THR PRO ALA SER VAL GLU SEQRES 2 L 219 ALA ALA VAL GLY GLY THR VAL THR ILE ASN CYS GLN ALA SEQRES 3 L 219 SER GLU SER ILE SER ASN TYR LEU SER TRP TYR GLN GLN SEQRES 4 L 219 LYS PRO GLY GLN ARG PRO LYS LEU LEU ILE TYR TYR ALA SEQRES 5 L 219 SER THR LEU ALA SER GLY VAL SER SER ARG PHE LYS GLY SEQRES 6 L 219 SER ARG SER GLY THR GLU TYR THR LEU THR ILE SER ASP SEQRES 7 L 219 LEU GLU CYS ALA ASP ALA ALA THR TYR TYR CYS GLN SER SEQRES 8 L 219 ALA ALA ASP SER ILE SER ASP LYS ARG HIS ALA PHE GLY SEQRES 9 L 219 GLY GLY THR GLU VAL LEU VAL LYS ARG THR VAL ALA ALA SEQRES 10 L 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 L 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 L 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 L 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 L 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 L 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 L 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 L 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 M 223 GLN GLU GLN LEU GLU GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 M 223 PRO GLU GLY SER LEU THR LEU THR CYS THR ALA SER GLY SEQRES 3 M 223 PHE SER PHE SER SER SER TYR TRP ILE CYS TRP VAL ARG SEQRES 4 M 223 GLN ALA PRO GLY LYS GLY LEU GLU TRP ILE GLY CYS ILE SEQRES 5 M 223 TYR THR GLY ASP GLY SER THR TYR TYR ALA THR TRP ALA SEQRES 6 M 223 LYS GLY ARG PHE THR ILE SER LYS ALA SER SER THR THR SEQRES 7 M 223 VAL THR LEU GLN MET THR SER LEU THR ALA ALA ASP THR SEQRES 8 M 223 ALA THR TYR PHE CYS THR ARG GLU GLY GLY TRP TYR ASP SEQRES 9 M 223 LEU ASN LEU TRP GLY PRO GLY THR LEU VAL THR VAL SER SEQRES 10 M 223 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11 M 223 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12 M 223 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13 M 223 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14 M 223 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15 M 223 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16 M 223 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17 M 223 ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS SEQRES 18 M 223 ASP LYS SEQRES 1 N 219 ALA ASP ILE VAL MET THR GLN THR PRO ALA SER VAL GLU SEQRES 2 N 219 ALA ALA VAL GLY GLY THR VAL THR ILE ASN CYS GLN ALA SEQRES 3 N 219 SER GLU SER ILE SER ASN TYR LEU SER TRP TYR GLN GLN SEQRES 4 N 219 LYS PRO GLY GLN ARG PRO LYS LEU LEU ILE TYR TYR ALA SEQRES 5 N 219 SER THR LEU ALA SER GLY VAL SER SER ARG PHE LYS GLY SEQRES 6 N 219 SER ARG SER GLY THR GLU TYR THR LEU THR ILE SER ASP SEQRES 7 N 219 LEU GLU CYS ALA ASP ALA ALA THR TYR TYR CYS GLN SER SEQRES 8 N 219 ALA ALA ASP SER ILE SER ASP LYS ARG HIS ALA PHE GLY SEQRES 9 N 219 GLY GLY THR GLU VAL LEU VAL LYS ARG THR VAL ALA ALA SEQRES 10 N 219 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 11 N 219 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 12 N 219 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 13 N 219 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 14 N 219 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 15 N 219 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 16 N 219 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 17 N 219 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS HET NAG D 1 14 HET NAG D 2 14 HET NAG E 1 14 HET NAG E 2 14 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG A1307 14 HET NAG A1308 14 HET NAG A1309 14 HET NAG A1310 14 HET NAG A1311 14 HET NAG A1312 14 HET NAG A1313 14 HET NAG A1314 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG B1307 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HET NAG C1307 14 HET NAG C1308 14 HET NAG C1309 14 HET NAG C1310 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 8 NAG 49(C8 H15 N O6) HELIX 1 AA1 ASP A 294 LYS A 304 1 11 HELIX 2 AA2 PRO A 337 ASN A 343 1 7 HELIX 3 AA3 TYR A 365 SER A 371 1 7 HELIX 4 AA4 GLY A 416 ASN A 422 1 7 HELIX 5 AA5 SER A 438 SER A 443 1 6 HELIX 6 AA6 GLY A 502 GLN A 506 5 5 HELIX 7 AA7 ASN A 616 VAL A 620 5 5 HELIX 8 AA8 ASP A 737 CYS A 743 1 7 HELIX 9 AA9 SER A 746 LEU A 754 1 9 HELIX 10 AB1 SER A 758 ALA A 783 1 26 HELIX 11 AB2 SER A 816 VAL A 826 1 11 HELIX 12 AB3 THR A 866 GLY A 885 1 20 HELIX 13 AB4 TRP A 886 GLY A 891 1 6 HELIX 14 AB5 PRO A 897 GLY A 910 1 14 HELIX 15 AB6 THR A 912 ASN A 919 1 8 HELIX 16 AB7 ASN A 919 THR A 941 1 23 HELIX 17 AB8 PRO A 942 ALA A 944 5 3 HELIX 18 AB9 LEU A 945 GLN A 965 1 21 HELIX 19 AC1 LEU A 966 SER A 968 5 3 HELIX 20 AC2 VAL A 976 SER A 982 1 7 HELIX 21 AC3 ASP A 985 VAL A 1033 1 49 HELIX 22 AC4 PRO A 1140 SER A 1147 1 8 HELIX 23 AC5 ASP B 294 LYS B 304 1 11 HELIX 24 AC6 PRO B 337 ASN B 343 1 7 HELIX 25 AC7 SER B 349 TRP B 353 5 5 HELIX 26 AC8 TYR B 365 SER B 371 1 7 HELIX 27 AC9 GLY B 416 ASN B 422 1 7 HELIX 28 AD1 SER B 438 SER B 443 1 6 HELIX 29 AD2 GLY B 502 GLN B 506 5 5 HELIX 30 AD3 ASP B 737 CYS B 743 1 7 HELIX 31 AD4 SER B 746 LEU B 754 1 9 HELIX 32 AD5 SER B 758 ALA B 783 1 26 HELIX 33 AD6 SER B 816 VAL B 826 1 11 HELIX 34 AD7 THR B 866 GLY B 885 1 20 HELIX 35 AD8 TRP B 886 ALA B 890 5 5 HELIX 36 AD9 PRO B 897 ILE B 909 1 13 HELIX 37 AE1 THR B 912 ASN B 919 1 8 HELIX 38 AE2 ASN B 919 THR B 941 1 23 HELIX 39 AE3 LEU B 945 GLN B 965 1 21 HELIX 40 AE4 LEU B 966 SER B 968 5 3 HELIX 41 AE5 VAL B 976 SER B 982 1 7 HELIX 42 AE6 ASP B 985 VAL B 1033 1 49 HELIX 43 AE7 LEU B 1141 SER B 1147 1 7 HELIX 44 AE8 ASP C 294 LYS C 304 1 11 HELIX 45 AE9 PRO C 337 ASN C 343 1 7 HELIX 46 AF1 SER C 349 TRP C 353 5 5 HELIX 47 AF2 ASP C 364 SER C 371 1 8 HELIX 48 AF3 THR C 385 LEU C 390 5 6 HELIX 49 AF4 GLY C 416 ASN C 422 1 7 HELIX 50 AF5 SER C 438 SER C 443 1 6 HELIX 51 AF6 ASP C 737 CYS C 743 1 7 HELIX 52 AF7 SER C 746 LEU C 754 1 9 HELIX 53 AF8 SER C 758 ALA C 783 1 26 HELIX 54 AF9 SER C 816 VAL C 826 1 11 HELIX 55 AG1 THR C 866 GLY C 885 1 20 HELIX 56 AG2 TRP C 886 GLY C 891 1 6 HELIX 57 AG3 PRO C 897 ILE C 909 1 13 HELIX 58 AG4 THR C 912 ASN C 919 1 8 HELIX 59 AG5 ASN C 919 THR C 941 1 23 HELIX 60 AG6 LEU C 945 GLN C 965 1 21 HELIX 61 AG7 LEU C 966 SER C 968 5 3 HELIX 62 AG8 VAL C 976 SER C 982 1 7 HELIX 63 AG9 ASP C 985 VAL C 1033 1 49 HELIX 64 AH1 PRO C 1140 SER C 1147 1 8 HELIX 65 AH2 GLY H 97 TYR H 99 5 3 SHEET 1 AA1 8 TYR A 28 THR A 29 0 SHEET 2 AA1 8 VAL A 62 HIS A 66 -1 O VAL A 62 N THR A 29 SHEET 3 AA1 8 ALA A 264 TYR A 269 -1 O VAL A 267 N THR A 63 SHEET 4 AA1 8 VAL A 90 THR A 95 -1 N ALA A 93 O TYR A 266 SHEET 5 AA1 8 LEU A 189 ILE A 197 -1 O ARG A 190 N SER A 94 SHEET 6 AA1 8 TYR A 200 LYS A 206 -1 O LYS A 206 N GLU A 191 SHEET 7 AA1 8 ALA A 222 VAL A 227 -1 O LEU A 226 N ILE A 203 SHEET 8 AA1 8 VAL A 36 TYR A 37 1 N VAL A 36 O LEU A 223 SHEET 1 AA2 7 VAL A 42 PHE A 43 0 SHEET 2 AA2 7 PHE B 565 GLY B 566 1 O PHE B 565 N PHE A 43 SHEET 3 AA2 7 ALA B 575 ARG B 577 -1 O ALA B 575 N GLY B 566 SHEET 4 AA2 7 ILE B 584 THR B 588 -1 O LEU B 585 N VAL B 576 SHEET 5 AA2 7 GLY B 548 GLU B 554 -1 N VAL B 551 O THR B 588 SHEET 6 AA2 7 CYS B 538 PHE B 543 -1 N PHE B 541 O GLY B 548 SHEET 7 AA2 7 SER B 325 ARG B 328 1 N ILE B 326 O ASN B 540 SHEET 1 AA3 3 LEU A 48 PHE A 55 0 SHEET 2 AA3 3 GLN A 271 TYR A 279 -1 O LEU A 277 N HIS A 49 SHEET 3 AA3 3 ILE A 285 ASP A 290 -1 O ASP A 287 N LYS A 278 SHEET 1 AA4 6 LEU A 84 PRO A 85 0 SHEET 2 AA4 6 ARG A 237 THR A 240 -1 O PHE A 238 N LEU A 84 SHEET 3 AA4 6 GLY A 103 GLY A 107 -1 N ILE A 105 O GLN A 239 SHEET 4 AA4 6 SER A 116 ASN A 121 -1 O LEU A 117 N PHE A 106 SHEET 5 AA4 6 VAL A 126 LYS A 129 -1 O LYS A 129 N LEU A 118 SHEET 6 AA4 6 GLU A 169 VAL A 171 -1 O TYR A 170 N ILE A 128 SHEET 1 AA5 2 LEU A 141 GLY A 142 0 SHEET 2 AA5 2 ALA A 243 LEU A 244 1 O LEU A 244 N LEU A 141 SHEET 1 AA6 5 GLY A 311 ARG A 319 0 SHEET 2 AA6 5 PHE A 592 THR A 599 -1 O VAL A 597 N TYR A 313 SHEET 3 AA6 5 ALA A 609 GLN A 613 -1 O LEU A 611 N SER A 596 SHEET 4 AA6 5 GLY A 648 ILE A 651 -1 O ILE A 651 N VAL A 610 SHEET 5 AA6 5 VAL A 642 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AA7 7 GLU A 324 ARG A 328 0 SHEET 2 AA7 7 CYS A 538 PHE A 543 1 O ASN A 540 N ILE A 326 SHEET 3 AA7 7 GLY A 548 GLU A 554 -1 O GLY A 548 N PHE A 541 SHEET 4 AA7 7 ILE A 584 THR A 588 -1 O THR A 588 N VAL A 551 SHEET 5 AA7 7 THR A 573 ARG A 577 -1 N VAL A 576 O LEU A 585 SHEET 6 AA7 7 PHE A 565 ARG A 567 -1 N GLY A 566 O ALA A 575 SHEET 7 AA7 7 VAL C 42 PHE C 43 1 O PHE C 43 N ARG A 567 SHEET 1 AA8 4 LYS A 356 ILE A 358 0 SHEET 2 AA8 4 ASN A 394 ILE A 402 -1 O ALA A 397 N LYS A 356 SHEET 3 AA8 4 TYR A 508 GLU A 516 -1 O TYR A 508 N ILE A 402 SHEET 4 AA8 4 CYS A 432 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 1 AA9 2 CYS A 391 PHE A 392 0 SHEET 2 AA9 2 VAL A 524 CYS A 525 -1 O VAL A 524 N PHE A 392 SHEET 1 AB1 2 ASN A 448 ARG A 454 0 SHEET 2 AB1 2 LEU A 492 TYR A 495 -1 O TYR A 495 N TYR A 451 SHEET 1 AB2 4 GLU A 654 HIS A 655 0 SHEET 2 AB2 4 SER A 691 THR A 696 1 O ILE A 692 N GLU A 654 SHEET 3 AB2 4 ILE A 670 GLN A 675 -1 N SER A 673 O ILE A 693 SHEET 4 AB2 4 ILE A 664 GLY A 667 -1 N ILE A 664 O ALA A 672 SHEET 1 AB3 2 ALA A 701 ASN A 703 0 SHEET 2 AB3 2 GLN C 787 TYR C 789 1 O ILE C 788 N ASN A 703 SHEET 1 AB4 2 SER A 711 PRO A 715 0 SHEET 2 AB4 2 GLU A1072 THR A1076 -1 O PHE A1075 N ILE A 712 SHEET 1 AB5 3 PHE A 718 PRO A 728 0 SHEET 2 AB5 3 GLY A1059 PRO A1069 -1 O THR A1066 N SER A 721 SHEET 3 AB5 3 TYR A1047 MET A1050 -1 N TYR A1047 O TYR A1067 SHEET 1 AB6 3 PHE A 718 PRO A 728 0 SHEET 2 AB6 3 GLY A1059 PRO A1069 -1 O THR A1066 N SER A 721 SHEET 3 AB6 3 PRO A1053 ALA A1056 -1 N GLN A1054 O VAL A1061 SHEET 1 AB7 2 LYS A 733 VAL A 736 0 SHEET 2 AB7 2 LEU A 858 LEU A 861 -1 O THR A 859 N SER A 735 SHEET 1 AB8 4 THR A1120 VAL A1122 0 SHEET 2 AB8 4 ALA A1087 PRO A1090 -1 N PHE A1089 O PHE A1121 SHEET 3 AB8 4 ILE A1081 CYS A1082 -1 N ILE A1081 O HIS A1088 SHEET 4 AB8 4 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SHEET 1 AB9 3 VAL A1094 SER A1097 0 SHEET 2 AB9 3 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 3 AB9 3 GLN A1113 ILE A1114 -1 O GLN A1113 N VAL A1104 SHEET 1 AC1 8 TYR B 28 SER B 31 0 SHEET 2 AC1 8 SER B 60 PHE B 65 -1 O VAL B 62 N THR B 29 SHEET 3 AC1 8 TYR B 265 TYR B 269 -1 O VAL B 267 N THR B 63 SHEET 4 AC1 8 VAL B 90 GLU B 96 -1 N ALA B 93 O TYR B 266 SHEET 5 AC1 8 ASN B 188 ILE B 197 -1 O PHE B 192 N PHE B 92 SHEET 6 AC1 8 TYR B 200 LYS B 206 -1 O LYS B 206 N GLU B 191 SHEET 7 AC1 8 ALA B 222 VAL B 227 -1 O LEU B 226 N ILE B 203 SHEET 8 AC1 8 VAL B 36 TYR B 37 1 N VAL B 36 O LEU B 223 SHEET 1 AC2 7 VAL B 42 PHE B 43 0 SHEET 2 AC2 7 PHE C 565 GLY C 566 1 O PHE C 565 N PHE B 43 SHEET 3 AC2 7 ALA C 575 ARG C 577 -1 O ALA C 575 N GLY C 566 SHEET 4 AC2 7 ILE C 584 THR C 588 -1 O LEU C 585 N VAL C 576 SHEET 5 AC2 7 GLY C 548 GLU C 554 -1 N THR C 553 O ASP C 586 SHEET 6 AC2 7 CYS C 538 ASN C 542 -1 N PHE C 541 O GLY C 548 SHEET 7 AC2 7 SER C 325 VAL C 327 1 N ILE C 326 O ASN C 540 SHEET 1 AC3 3 LEU B 48 PHE B 55 0 SHEET 2 AC3 3 GLN B 271 TYR B 279 -1 O PHE B 275 N THR B 51 SHEET 3 AC3 3 ILE B 285 ASP B 290 -1 O ASP B 287 N LYS B 278 SHEET 1 AC4 6 LEU B 84 PRO B 85 0 SHEET 2 AC4 6 ARG B 237 THR B 240 -1 O PHE B 238 N LEU B 84 SHEET 3 AC4 6 GLY B 103 GLY B 107 -1 N ILE B 105 O GLN B 239 SHEET 4 AC4 6 SER B 116 ASN B 121 -1 O ILE B 119 N TRP B 104 SHEET 5 AC4 6 VAL B 126 LYS B 129 -1 O LYS B 129 N LEU B 118 SHEET 6 AC4 6 TYR B 170 VAL B 171 -1 O TYR B 170 N ILE B 128 SHEET 1 AC5 3 GLY B 311 TYR B 313 0 SHEET 2 AC5 3 PHE B 592 THR B 599 -1 O VAL B 597 N TYR B 313 SHEET 3 AC5 3 ASN B 317 ARG B 319 -1 N PHE B 318 O GLY B 593 SHEET 1 AC6 5 GLY B 311 TYR B 313 0 SHEET 2 AC6 5 PHE B 592 THR B 599 -1 O VAL B 597 N TYR B 313 SHEET 3 AC6 5 ALA B 609 TYR B 612 -1 O LEU B 611 N SER B 596 SHEET 4 AC6 5 CYS B 649 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AC6 5 PHE B 643 GLN B 644 -1 N PHE B 643 O LEU B 650 SHEET 1 AC7 4 ASN B 354 ILE B 358 0 SHEET 2 AC7 4 ASN B 394 ILE B 402 -1 O ALA B 397 N LYS B 356 SHEET 3 AC7 4 TYR B 508 GLU B 516 -1 O VAL B 512 N ASP B 398 SHEET 4 AC7 4 CYS B 432 ASN B 437 -1 N TRP B 436 O ARG B 509 SHEET 1 AC8 2 CYS B 391 PHE B 392 0 SHEET 2 AC8 2 VAL B 524 CYS B 525 -1 O VAL B 524 N PHE B 392 SHEET 1 AC9 2 LEU B 452 ARG B 454 0 SHEET 2 AC9 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AD1 4 ALA B 653 HIS B 655 0 SHEET 2 AD1 4 SER B 691 THR B 696 1 O ILE B 692 N GLU B 654 SHEET 3 AD1 4 ILE B 670 GLN B 675 -1 N CYS B 671 O TYR B 695 SHEET 4 AD1 4 ILE B 664 PRO B 665 -1 N ILE B 664 O ALA B 672 SHEET 1 AD2 2 SER B 711 PRO B 715 0 SHEET 2 AD2 2 GLU B1072 THR B1076 -1 O PHE B1075 N ILE B 712 SHEET 1 AD3 3 PHE B 718 PRO B 728 0 SHEET 2 AD3 3 GLY B1059 PRO B1069 -1 O THR B1066 N SER B 721 SHEET 3 AD3 3 TYR B1047 MET B1050 -1 N TYR B1047 O TYR B1067 SHEET 1 AD4 3 PHE B 718 PRO B 728 0 SHEET 2 AD4 3 GLY B1059 PRO B1069 -1 O THR B1066 N SER B 721 SHEET 3 AD4 3 PRO B1053 ALA B1056 -1 N GLN B1054 O VAL B1061 SHEET 1 AD5 2 LYS B 733 VAL B 736 0 SHEET 2 AD5 2 LEU B 858 LEU B 861 -1 O LEU B 861 N LYS B 733 SHEET 1 AD6 4 THR B1120 VAL B1122 0 SHEET 2 AD6 4 ALA B1087 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AD6 4 ILE B1081 CYS B1082 -1 N ILE B1081 O HIS B1088 SHEET 4 AD6 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AD7 3 VAL B1094 SER B1097 0 SHEET 2 AD7 3 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 3 AD7 3 GLN B1113 ILE B1114 -1 O GLN B1113 N VAL B1104 SHEET 1 AD8 7 TYR C 28 SER C 31 0 SHEET 2 AD8 7 SER C 60 PHE C 65 -1 O VAL C 62 N THR C 29 SHEET 3 AD8 7 TYR C 265 TYR C 269 -1 O VAL C 267 N THR C 63 SHEET 4 AD8 7 VAL C 90 THR C 95 -1 N ALA C 93 O TYR C 266 SHEET 5 AD8 7 LEU C 189 ILE C 197 -1 O PHE C 192 N PHE C 92 SHEET 6 AD8 7 TYR C 200 LYS C 206 -1 O LYS C 202 N LYS C 195 SHEET 7 AD8 7 GLU C 224 LEU C 229 -1 O LEU C 226 N ILE C 203 SHEET 1 AD9 3 LEU C 48 THR C 51 0 SHEET 2 AD9 3 PHE C 275 TYR C 279 -1 O PHE C 275 N THR C 51 SHEET 3 AD9 3 ILE C 285 ASP C 290 -1 O ASP C 287 N LYS C 278 SHEET 1 AE1 2 LEU C 54 PHE C 55 0 SHEET 2 AE1 2 GLN C 271 PRO C 272 -1 O GLN C 271 N PHE C 55 SHEET 1 AE2 5 GLU C 169 VAL C 171 0 SHEET 2 AE2 5 VAL C 126 LYS C 129 -1 N ILE C 128 O TYR C 170 SHEET 3 AE2 5 SER C 116 ASN C 121 -1 N VAL C 120 O VAL C 127 SHEET 4 AE2 5 TRP C 104 GLY C 107 -1 N PHE C 106 O LEU C 117 SHEET 5 AE2 5 GLN C 239 THR C 240 -1 O GLN C 239 N ILE C 105 SHEET 1 AE3 2 PHE C 140 LEU C 141 0 SHEET 2 AE3 2 LEU C 242 ALA C 243 1 O LEU C 242 N LEU C 141 SHEET 1 AE4 5 GLY C 311 ARG C 319 0 SHEET 2 AE4 5 PHE C 592 THR C 599 -1 O VAL C 597 N TYR C 313 SHEET 3 AE4 5 ALA C 609 GLN C 613 -1 O LEU C 611 N SER C 596 SHEET 4 AE4 5 GLY C 648 ILE C 651 -1 O ILE C 651 N VAL C 610 SHEET 5 AE4 5 VAL C 642 GLN C 644 -1 N PHE C 643 O LEU C 650 SHEET 1 AE5 4 LYS C 356 ILE C 358 0 SHEET 2 AE5 4 ASN C 394 ILE C 402 -1 O ALA C 397 N LYS C 356 SHEET 3 AE5 4 TYR C 508 GLU C 516 -1 O SER C 514 N TYR C 396 SHEET 4 AE5 4 CYS C 432 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 1 AE6 2 LEU C 452 ARG C 454 0 SHEET 2 AE6 2 LEU C 492 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AE7 4 ALA C 653 HIS C 655 0 SHEET 2 AE7 4 SER C 691 THR C 696 1 O ILE C 692 N GLU C 654 SHEET 3 AE7 4 ILE C 670 GLN C 675 -1 N SER C 673 O ILE C 693 SHEET 4 AE7 4 ILE C 664 PRO C 665 -1 N ILE C 664 O ALA C 672 SHEET 1 AE8 2 SER C 711 PRO C 715 0 SHEET 2 AE8 2 GLU C1072 THR C1076 -1 O PHE C1075 N ILE C 712 SHEET 1 AE9 3 PHE C 718 PRO C 728 0 SHEET 2 AE9 3 GLY C1059 PRO C1069 -1 O THR C1066 N SER C 721 SHEET 3 AE9 3 TYR C1047 MET C1050 -1 N LEU C1049 O VAL C1065 SHEET 1 AF1 3 PHE C 718 PRO C 728 0 SHEET 2 AF1 3 GLY C1059 PRO C1069 -1 O THR C1066 N SER C 721 SHEET 3 AF1 3 PRO C1053 ALA C1056 -1 N GLN C1054 O VAL C1061 SHEET 1 AF2 2 LYS C 733 VAL C 736 0 SHEET 2 AF2 2 LEU C 858 LEU C 861 -1 O LEU C 861 N LYS C 733 SHEET 1 AF3 4 THR C1120 VAL C1122 0 SHEET 2 AF3 4 ALA C1087 PRO C1090 -1 N PHE C1089 O PHE C1121 SHEET 3 AF3 4 ILE C1081 CYS C1082 -1 N ILE C1081 O HIS C1088 SHEET 4 AF3 4 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AF4 2 VAL C1094 SER C1097 0 SHEET 2 AF4 2 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 1 AF5 2 LEU H 4 SER H 7 0 SHEET 2 AF5 2 THR H 21 ALA H 24 -1 O THR H 23 N GLU H 5 SHEET 1 AF6 2 THR H 68 ILE H 69 0 SHEET 2 AF6 2 GLN H 80 MET H 81 -1 O MET H 81 N THR H 68 SHEET 1 AF7 2 ARG H 94 GLU H 95 0 SHEET 2 AF7 2 LEU H 100A LEU H 102 -1 O LEU H 102 N ARG H 94 SHEET 1 AF8 2 GLU L 12 ALA L 13 0 SHEET 2 AF8 2 LEU L 105 VAL L 106 1 O LEU L 105 N ALA L 13 SHEET 1 AF9 2 GLY L 16 CYS L 23 0 SHEET 2 AF9 2 TYR L 71 LEU L 78 -1 O ASP L 77 N GLY L 17 SHEET 1 AG1 4 LYS L 45 LEU L 46 0 SHEET 2 AG1 4 LEU L 33 GLN L 38 -1 N GLN L 37 O LYS L 45 SHEET 3 AG1 4 THR L 85 ALA L 91 -1 O THR L 85 N GLN L 38 SHEET 4 AG1 4 HIS L 96 PHE L 98 -1 O ALA L 97 N SER L 90 SHEET 1 AG2 4 LEU M 4 SER M 7 0 SHEET 2 AG2 4 THR M 19 ALA M 24 -1 O THR M 23 N GLU M 5 SHEET 3 AG2 4 THR M 78 THR M 82 -1 O THR M 78 N CYS M 22 SHEET 4 AG2 4 PHE M 67 ILE M 69 -1 N THR M 68 O MET M 81 SHEET 1 AG3 2 ARG M 94 GLY M 96 0 SHEET 2 AG3 2 ASP M 100 LEU M 102 -1 O LEU M 102 N ARG M 94 SHEET 1 AG4 2 SER N 10 ALA N 13 0 SHEET 2 AG4 2 GLU N 103 VAL N 106 1 O LEU N 105 N VAL N 11 SHEET 1 AG5 3 THR N 18 ASN N 22 0 SHEET 2 AG5 3 THR N 72 SER N 76 -1 O LEU N 73 N ILE N 21 SHEET 3 AG5 3 LYS N 63 SER N 65 -1 N SER N 65 O THR N 72 SHEET 1 AG6 4 LYS N 45 LEU N 46 0 SHEET 2 AG6 4 LEU N 33 GLN N 38 -1 N GLN N 37 O LYS N 45 SHEET 3 AG6 4 THR N 85 ALA N 91 -1 O GLN N 89 N SER N 34 SHEET 4 AG6 4 HIS N 96 PHE N 98 -1 O ALA N 97 N SER N 90 SSBOND 1 CYS A 131 CYS A 166 1555 1555 2.03 SSBOND 2 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 3 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 4 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 5 CYS A 391 CYS A 525 1555 1555 2.04 SSBOND 6 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 7 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 8 CYS A 662 CYS A 671 1555 1555 2.03 SSBOND 9 CYS A 738 CYS A 760 1555 1555 2.03 SSBOND 10 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 11 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 12 CYS A 1082 CYS A 1126 1555 1555 2.03 SSBOND 13 CYS B 131 CYS B 166 1555 1555 2.03 SSBOND 14 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 15 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 16 CYS B 391 CYS B 525 1555 1555 2.03 SSBOND 17 CYS B 480 CYS B 488 1555 1555 2.03 SSBOND 18 CYS B 538 CYS B 590 1555 1555 2.04 SSBOND 19 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 20 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 21 CYS B 738 CYS B 760 1555 1555 2.02 SSBOND 22 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 23 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 24 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 25 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 26 CYS C 291 CYS C 301 1555 1555 2.02 SSBOND 27 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 28 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 29 CYS C 391 CYS C 525 1555 1555 2.03 SSBOND 30 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 31 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 32 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 33 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 34 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 35 CYS C 1032 CYS C 1043 1555 1555 2.03 SSBOND 36 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 37 CYS H 35A CYS H 92 1555 1555 2.03 SSBOND 38 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 39 CYS M 35A CYS M 92 1555 1555 2.03 SSBOND 40 CYS N 23 CYS N 88 1555 1555 2.03 LINK ND2 ASN A 61 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 122 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 165 C1 NAG A1303 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 282 C1 NAG A1314 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG A1305 1555 1555 1.46 LINK ND2 ASN A 343 C1 NAG A1313 1555 1555 1.44 LINK ND2 ASN A 603 C1 NAG A1306 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1307 1555 1555 1.44 LINK ND2 ASN A 657 C1 NAG A1308 1555 1555 1.45 LINK ND2 ASN A 709 C1 NAG A1309 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG D 1 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN A1074 C1 NAG A1310 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG A1311 1555 1555 1.44 LINK ND2 ASN A1134 C1 NAG A1312 1555 1555 1.44 LINK ND2 ASN B 61 C1 NAG B1301 1555 1555 1.44 LINK ND2 ASN B 282 C1 NAG B1307 1555 1555 1.45 LINK ND2 ASN B 331 C1 NAG F 1 1555 1555 1.45 LINK ND2 ASN B 343 C1 NAG B1306 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1302 1555 1555 1.45 LINK ND2 ASN B 709 C1 NAG B1303 1555 1555 1.44 LINK ND2 ASN B 717 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN B 801 C1 NAG J 1 1555 1555 1.44 LINK ND2 ASN B1074 C1 NAG B1304 1555 1555 1.44 LINK ND2 ASN B1098 C1 NAG I 1 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG B1305 1555 1555 1.45 LINK ND2 ASN C 61 C1 NAG C1301 1555 1555 1.44 LINK ND2 ASN C 165 C1 NAG C1310 1555 1555 1.44 LINK ND2 ASN C 282 C1 NAG C1309 1555 1555 1.44 LINK ND2 ASN C 343 C1 NAG C1308 1555 1555 1.44 LINK ND2 ASN C 603 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C 616 C1 NAG C1303 1555 1555 1.44 LINK ND2 ASN C 657 C1 NAG C1304 1555 1555 1.45 LINK ND2 ASN C 709 C1 NAG C1305 1555 1555 1.44 LINK ND2 ASN C 717 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN C1074 C1 NAG C1306 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG C1307 1555 1555 1.44 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.44 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.46 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.44 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.45 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000