HEADER VIRAL PROTEIN/IMMUNE SYSTEM 18-DEC-24 9ML6 TITLE STRUCTURE OF THE SARS-COV-2 SPIKE 6P IN COMPLEX WITH THE RABBIT M8B-C9 TITLE 2 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: SPIKE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: SPIKE HEXAPRO (6P),S GLYCOPROTEIN,E2,PEPLOMER PROTEIN; COMPND 5 ENGINEERED: YES; COMPND 6 MUTATION: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: M8B-C9 HEAVY CHAIN; COMPND 9 CHAIN: H, M, P; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: M8B-C9 LIGHT CHAIN; COMPND 13 CHAIN: L, N, Q; COMPND 14 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS SOURCE 3 2; SOURCE 4 ORGANISM_TAXID: 2697049; SOURCE 5 GENE: S, 2; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; SOURCE 11 ORGANISM_COMMON: RABBIT; SOURCE 12 ORGANISM_TAXID: 9986; SOURCE 13 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 14 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 MOL_ID: 3; SOURCE 17 ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; SOURCE 18 ORGANISM_COMMON: RABBIT; SOURCE 19 ORGANISM_TAXID: 9986; SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 21 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS IMMUNE SYSTEM, NEUTRALIZING ANTIBODY, IMMUNE SYSTEM-VIRAL PROTEIN KEYWDS 2 COMPLEX, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR C.FAN,P.J.BJORKMAN REVDAT 1 04-JUN-25 9ML6 0 JRNL AUTH C.FAN,J.R.KEEFFE,K.E.MALECEK,A.A.COHEN,A.P.WEST JR., JRNL AUTH 2 V.A.BAHARANI,A.V.RORICK,H.GAO,P.N.P.GNANAPRAGASAM,S.RHO, JRNL AUTH 3 J.ALVAREZ,L.N.SEGOVIA,T.HATZIIOANNOU,P.D.BIENIASZ, JRNL AUTH 4 P.J.BJORKMAN JRNL TITL CROSS-REACTIVE SARBECOVIRUS ANTIBODIES INDUCED BY MOSAIC RBD JRNL TITL 2 NANOPARTICLES. JRNL REF PROC.NATL.ACAD.SCI.USA V. 122 37122 2025 JRNL REFN ESSN 1091-6490 JRNL PMID 40402246 JRNL DOI 10.1073/PNAS.2501637122 REMARK 2 REMARK 2 RESOLUTION. 3.50 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, SERIALEM, CRYOSPARC, UCSF REMARK 3 CHIMERA, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 7UZD REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : 90.000 REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.500 REMARK 3 NUMBER OF PARTICLES : 132671 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9ML6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-DEC-24. REMARK 100 THE DEPOSITION ID IS D_1000290165. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : SARS-COV-2 SPIKE 6P IN COMPLEX REMARK 245 WITH M8B-C9 FAB; SEVERE ACUTE REMARK 245 RESPIRATORY SYNDROME REMARK 245 CORONAVIRUS 2 SPIKE REMARK 245 GLYCOPROTEIN; M8B-C9 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 2.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 8.00 REMARK 245 SAMPLE DETAILS : STABILIZED WITH HEXAPROLINE REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 4656 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 105000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, H, L, M, N, P, Q REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 PHE A 2 REMARK 465 VAL A 3 REMARK 465 PHE A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 PRO A 9 REMARK 465 LEU A 10 REMARK 465 VAL A 11 REMARK 465 SER A 12 REMARK 465 SER A 13 REMARK 465 GLN A 14 REMARK 465 CYS A 15 REMARK 465 VAL A 16 REMARK 465 ASN A 17 REMARK 465 LEU A 18 REMARK 465 THR A 19 REMARK 465 THR A 20 REMARK 465 ARG A 21 REMARK 465 THR A 22 REMARK 465 GLN A 23 REMARK 465 LEU A 24 REMARK 465 PRO A 25 REMARK 465 PRO A 26 REMARK 465 VAL A 70 REMARK 465 SER A 71 REMARK 465 GLY A 72 REMARK 465 THR A 73 REMARK 465 ASN A 74 REMARK 465 GLY A 75 REMARK 465 THR A 76 REMARK 465 LYS A 77 REMARK 465 TYR A 144 REMARK 465 TYR A 145 REMARK 465 HIS A 146 REMARK 465 LYS A 147 REMARK 465 ASN A 148 REMARK 465 ASN A 149 REMARK 465 LYS A 150 REMARK 465 SER A 151 REMARK 465 TRP A 152 REMARK 465 MET A 153 REMARK 465 GLU A 154 REMARK 465 SER A 155 REMARK 465 GLU A 156 REMARK 465 PHE A 157 REMARK 465 ARG A 158 REMARK 465 VAL A 159 REMARK 465 TYR A 160 REMARK 465 SER A 161 REMARK 465 SER A 162 REMARK 465 ALA A 163 REMARK 465 ASN A 164 REMARK 465 GLN A 173 REMARK 465 PRO A 174 REMARK 465 PHE A 175 REMARK 465 LEU A 176 REMARK 465 MET A 177 REMARK 465 ASP A 178 REMARK 465 LEU A 179 REMARK 465 GLU A 180 REMARK 465 GLY A 181 REMARK 465 LYS A 182 REMARK 465 GLN A 183 REMARK 465 GLY A 184 REMARK 465 ASN A 185 REMARK 465 ARG A 246 REMARK 465 SER A 247 REMARK 465 TYR A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 PRO A 251 REMARK 465 GLY A 252 REMARK 465 ASP A 253 REMARK 465 SER A 254 REMARK 465 SER A 255 REMARK 465 SER A 256 REMARK 465 GLY A 257 REMARK 465 TRP A 258 REMARK 465 THR A 259 REMARK 465 ALA A 260 REMARK 465 GLY A 261 REMARK 465 ALA A 262 REMARK 465 ALA A 623 REMARK 465 ILE A 624 REMARK 465 HIS A 625 REMARK 465 ALA A 626 REMARK 465 ASP A 627 REMARK 465 GLN A 628 REMARK 465 LEU A 629 REMARK 465 THR A 630 REMARK 465 PRO A 631 REMARK 465 THR A 632 REMARK 465 TRP A 633 REMARK 465 ARG A 634 REMARK 465 VAL A 635 REMARK 465 GLN A 680 REMARK 465 THR A 681 REMARK 465 ASN A 682 REMARK 465 SER A 683 REMARK 465 PRO A 684 REMARK 465 ALA A 685 REMARK 465 SER A 686 REMARK 465 VAL A 687 REMARK 465 ALA A 688 REMARK 465 LEU A 828 REMARK 465 ALA A 829 REMARK 465 ASP A 830 REMARK 465 ALA A 831 REMARK 465 GLY A 832 REMARK 465 PHE A 833 REMARK 465 ILE A 834 REMARK 465 LYS A 835 REMARK 465 GLN A 836 REMARK 465 TYR A 837 REMARK 465 GLY A 838 REMARK 465 ASP A 839 REMARK 465 CYS A 840 REMARK 465 LEU A 841 REMARK 465 GLY A 842 REMARK 465 ASP A 843 REMARK 465 ILE A 844 REMARK 465 ALA A 845 REMARK 465 ALA A 846 REMARK 465 ARG A 847 REMARK 465 ASP A 848 REMARK 465 LEU A 849 REMARK 465 ILE A 850 REMARK 465 CYS A 851 REMARK 465 ALA A 852 REMARK 465 GLN A 853 REMARK 465 PHE A 1148 REMARK 465 LYS A 1149 REMARK 465 GLU A 1150 REMARK 465 GLU A 1151 REMARK 465 LEU A 1152 REMARK 465 ASP A 1153 REMARK 465 LYS A 1154 REMARK 465 TYR A 1155 REMARK 465 PHE A 1156 REMARK 465 LYS A 1157 REMARK 465 ASN A 1158 REMARK 465 HIS A 1159 REMARK 465 THR A 1160 REMARK 465 SER A 1161 REMARK 465 PRO A 1162 REMARK 465 ASP A 1163 REMARK 465 VAL A 1164 REMARK 465 ASP A 1165 REMARK 465 LEU A 1166 REMARK 465 GLY A 1167 REMARK 465 ASP A 1168 REMARK 465 ILE A 1169 REMARK 465 SER A 1170 REMARK 465 GLY A 1171 REMARK 465 ILE A 1172 REMARK 465 ASN A 1173 REMARK 465 ALA A 1174 REMARK 465 SER A 1175 REMARK 465 VAL A 1176 REMARK 465 VAL A 1177 REMARK 465 ASN A 1178 REMARK 465 ILE A 1179 REMARK 465 GLN A 1180 REMARK 465 LYS A 1181 REMARK 465 GLU A 1182 REMARK 465 ILE A 1183 REMARK 465 ASP A 1184 REMARK 465 ARG A 1185 REMARK 465 LEU A 1186 REMARK 465 ASN A 1187 REMARK 465 GLU A 1188 REMARK 465 VAL A 1189 REMARK 465 ALA A 1190 REMARK 465 LYS A 1191 REMARK 465 ASN A 1192 REMARK 465 LEU A 1193 REMARK 465 ASN A 1194 REMARK 465 GLU A 1195 REMARK 465 SER A 1196 REMARK 465 LEU A 1197 REMARK 465 ILE A 1198 REMARK 465 ASP A 1199 REMARK 465 LEU A 1200 REMARK 465 GLN A 1201 REMARK 465 GLU A 1202 REMARK 465 LEU A 1203 REMARK 465 GLY A 1204 REMARK 465 LYS A 1205 REMARK 465 TYR A 1206 REMARK 465 GLU A 1207 REMARK 465 GLN A 1208 REMARK 465 TYR A 1209 REMARK 465 ILE A 1210 REMARK 465 LYS A 1211 REMARK 465 TRP A 1212 REMARK 465 PRO A 1213 REMARK 465 SER A 1214 REMARK 465 GLY A 1215 REMARK 465 ARG A 1216 REMARK 465 LEU A 1217 REMARK 465 VAL A 1218 REMARK 465 PRO A 1219 REMARK 465 ARG A 1220 REMARK 465 GLY A 1221 REMARK 465 SER A 1222 REMARK 465 PRO A 1223 REMARK 465 GLY A 1224 REMARK 465 SER A 1225 REMARK 465 GLY A 1226 REMARK 465 TYR A 1227 REMARK 465 ILE A 1228 REMARK 465 PRO A 1229 REMARK 465 GLU A 1230 REMARK 465 ALA A 1231 REMARK 465 PRO A 1232 REMARK 465 ARG A 1233 REMARK 465 ASP A 1234 REMARK 465 GLY A 1235 REMARK 465 GLN A 1236 REMARK 465 ALA A 1237 REMARK 465 TYR A 1238 REMARK 465 VAL A 1239 REMARK 465 ARG A 1240 REMARK 465 LYS A 1241 REMARK 465 ASP A 1242 REMARK 465 GLY A 1243 REMARK 465 GLU A 1244 REMARK 465 TRP A 1245 REMARK 465 VAL A 1246 REMARK 465 LEU A 1247 REMARK 465 LEU A 1248 REMARK 465 SER A 1249 REMARK 465 THR A 1250 REMARK 465 PHE A 1251 REMARK 465 LEU A 1252 REMARK 465 GLY A 1253 REMARK 465 HIS A 1254 REMARK 465 HIS A 1255 REMARK 465 HIS A 1256 REMARK 465 HIS A 1257 REMARK 465 HIS A 1258 REMARK 465 HIS A 1259 REMARK 465 MET B 1 REMARK 465 PHE B 2 REMARK 465 VAL B 3 REMARK 465 PHE B 4 REMARK 465 LEU B 5 REMARK 465 VAL B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 PRO B 9 REMARK 465 LEU B 10 REMARK 465 VAL B 11 REMARK 465 SER B 12 REMARK 465 SER B 13 REMARK 465 GLN B 14 REMARK 465 CYS B 15 REMARK 465 VAL B 16 REMARK 465 ASN B 17 REMARK 465 LEU B 18 REMARK 465 THR B 19 REMARK 465 THR B 20 REMARK 465 ARG B 21 REMARK 465 THR B 22 REMARK 465 GLN B 23 REMARK 465 LEU B 24 REMARK 465 PRO B 25 REMARK 465 PRO B 26 REMARK 465 VAL B 70 REMARK 465 SER B 71 REMARK 465 GLY B 72 REMARK 465 THR B 73 REMARK 465 ASN B 74 REMARK 465 GLY B 75 REMARK 465 THR B 76 REMARK 465 LYS B 77 REMARK 465 TYR B 144 REMARK 465 TYR B 145 REMARK 465 HIS B 146 REMARK 465 LYS B 147 REMARK 465 ASN B 148 REMARK 465 ASN B 149 REMARK 465 LYS B 150 REMARK 465 SER B 151 REMARK 465 TRP B 152 REMARK 465 MET B 153 REMARK 465 GLU B 154 REMARK 465 SER B 155 REMARK 465 GLU B 156 REMARK 465 PHE B 157 REMARK 465 ARG B 158 REMARK 465 VAL B 159 REMARK 465 TYR B 160 REMARK 465 SER B 161 REMARK 465 SER B 162 REMARK 465 ALA B 163 REMARK 465 ASN B 164 REMARK 465 GLN B 173 REMARK 465 PRO B 174 REMARK 465 PHE B 175 REMARK 465 LEU B 176 REMARK 465 MET B 177 REMARK 465 ASP B 178 REMARK 465 LEU B 179 REMARK 465 GLU B 180 REMARK 465 GLY B 181 REMARK 465 LYS B 182 REMARK 465 GLN B 183 REMARK 465 GLY B 184 REMARK 465 ASN B 185 REMARK 465 ARG B 246 REMARK 465 SER B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 GLY B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 SER B 255 REMARK 465 SER B 256 REMARK 465 GLY B 257 REMARK 465 TRP B 258 REMARK 465 THR B 259 REMARK 465 ALA B 260 REMARK 465 GLY B 261 REMARK 465 ALA B 262 REMARK 465 ALA B 623 REMARK 465 ILE B 624 REMARK 465 HIS B 625 REMARK 465 ALA B 626 REMARK 465 ASP B 627 REMARK 465 GLN B 628 REMARK 465 LEU B 629 REMARK 465 THR B 630 REMARK 465 PRO B 631 REMARK 465 THR B 632 REMARK 465 TRP B 633 REMARK 465 ARG B 634 REMARK 465 VAL B 635 REMARK 465 GLN B 680 REMARK 465 THR B 681 REMARK 465 ASN B 682 REMARK 465 SER B 683 REMARK 465 PRO B 684 REMARK 465 ALA B 685 REMARK 465 SER B 686 REMARK 465 VAL B 687 REMARK 465 ALA B 688 REMARK 465 LEU B 828 REMARK 465 ALA B 829 REMARK 465 ASP B 830 REMARK 465 ALA B 831 REMARK 465 GLY B 832 REMARK 465 PHE B 833 REMARK 465 ILE B 834 REMARK 465 LYS B 835 REMARK 465 GLN B 836 REMARK 465 TYR B 837 REMARK 465 GLY B 838 REMARK 465 ASP B 839 REMARK 465 CYS B 840 REMARK 465 LEU B 841 REMARK 465 GLY B 842 REMARK 465 ASP B 843 REMARK 465 ILE B 844 REMARK 465 ALA B 845 REMARK 465 ALA B 846 REMARK 465 ARG B 847 REMARK 465 ASP B 848 REMARK 465 LEU B 849 REMARK 465 ILE B 850 REMARK 465 CYS B 851 REMARK 465 ALA B 852 REMARK 465 GLN B 853 REMARK 465 PHE B 1148 REMARK 465 LYS B 1149 REMARK 465 GLU B 1150 REMARK 465 GLU B 1151 REMARK 465 LEU B 1152 REMARK 465 ASP B 1153 REMARK 465 LYS B 1154 REMARK 465 TYR B 1155 REMARK 465 PHE B 1156 REMARK 465 LYS B 1157 REMARK 465 ASN B 1158 REMARK 465 HIS B 1159 REMARK 465 THR B 1160 REMARK 465 SER B 1161 REMARK 465 PRO B 1162 REMARK 465 ASP B 1163 REMARK 465 VAL B 1164 REMARK 465 ASP B 1165 REMARK 465 LEU B 1166 REMARK 465 GLY B 1167 REMARK 465 ASP B 1168 REMARK 465 ILE B 1169 REMARK 465 SER B 1170 REMARK 465 GLY B 1171 REMARK 465 ILE B 1172 REMARK 465 ASN B 1173 REMARK 465 ALA B 1174 REMARK 465 SER B 1175 REMARK 465 VAL B 1176 REMARK 465 VAL B 1177 REMARK 465 ASN B 1178 REMARK 465 ILE B 1179 REMARK 465 GLN B 1180 REMARK 465 LYS B 1181 REMARK 465 GLU B 1182 REMARK 465 ILE B 1183 REMARK 465 ASP B 1184 REMARK 465 ARG B 1185 REMARK 465 LEU B 1186 REMARK 465 ASN B 1187 REMARK 465 GLU B 1188 REMARK 465 VAL B 1189 REMARK 465 ALA B 1190 REMARK 465 LYS B 1191 REMARK 465 ASN B 1192 REMARK 465 LEU B 1193 REMARK 465 ASN B 1194 REMARK 465 GLU B 1195 REMARK 465 SER B 1196 REMARK 465 LEU B 1197 REMARK 465 ILE B 1198 REMARK 465 ASP B 1199 REMARK 465 LEU B 1200 REMARK 465 GLN B 1201 REMARK 465 GLU B 1202 REMARK 465 LEU B 1203 REMARK 465 GLY B 1204 REMARK 465 LYS B 1205 REMARK 465 TYR B 1206 REMARK 465 GLU B 1207 REMARK 465 GLN B 1208 REMARK 465 TYR B 1209 REMARK 465 ILE B 1210 REMARK 465 LYS B 1211 REMARK 465 TRP B 1212 REMARK 465 PRO B 1213 REMARK 465 SER B 1214 REMARK 465 GLY B 1215 REMARK 465 ARG B 1216 REMARK 465 LEU B 1217 REMARK 465 VAL B 1218 REMARK 465 PRO B 1219 REMARK 465 ARG B 1220 REMARK 465 GLY B 1221 REMARK 465 SER B 1222 REMARK 465 PRO B 1223 REMARK 465 GLY B 1224 REMARK 465 SER B 1225 REMARK 465 GLY B 1226 REMARK 465 TYR B 1227 REMARK 465 ILE B 1228 REMARK 465 PRO B 1229 REMARK 465 GLU B 1230 REMARK 465 ALA B 1231 REMARK 465 PRO B 1232 REMARK 465 ARG B 1233 REMARK 465 ASP B 1234 REMARK 465 GLY B 1235 REMARK 465 GLN B 1236 REMARK 465 ALA B 1237 REMARK 465 TYR B 1238 REMARK 465 VAL B 1239 REMARK 465 ARG B 1240 REMARK 465 LYS B 1241 REMARK 465 ASP B 1242 REMARK 465 GLY B 1243 REMARK 465 GLU B 1244 REMARK 465 TRP B 1245 REMARK 465 VAL B 1246 REMARK 465 LEU B 1247 REMARK 465 LEU B 1248 REMARK 465 SER B 1249 REMARK 465 THR B 1250 REMARK 465 PHE B 1251 REMARK 465 LEU B 1252 REMARK 465 GLY B 1253 REMARK 465 HIS B 1254 REMARK 465 HIS B 1255 REMARK 465 HIS B 1256 REMARK 465 HIS B 1257 REMARK 465 HIS B 1258 REMARK 465 HIS B 1259 REMARK 465 MET C 1 REMARK 465 PHE C 2 REMARK 465 VAL C 3 REMARK 465 PHE C 4 REMARK 465 LEU C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 PRO C 9 REMARK 465 LEU C 10 REMARK 465 VAL C 11 REMARK 465 SER C 12 REMARK 465 SER C 13 REMARK 465 GLN C 14 REMARK 465 CYS C 15 REMARK 465 VAL C 16 REMARK 465 ASN C 17 REMARK 465 LEU C 18 REMARK 465 THR C 19 REMARK 465 THR C 20 REMARK 465 ARG C 21 REMARK 465 THR C 22 REMARK 465 GLN C 23 REMARK 465 LEU C 24 REMARK 465 PRO C 25 REMARK 465 PRO C 26 REMARK 465 VAL C 70 REMARK 465 SER C 71 REMARK 465 GLY C 72 REMARK 465 THR C 73 REMARK 465 ASN C 74 REMARK 465 GLY C 75 REMARK 465 THR C 76 REMARK 465 LYS C 77 REMARK 465 TYR C 144 REMARK 465 TYR C 145 REMARK 465 HIS C 146 REMARK 465 LYS C 147 REMARK 465 ASN C 148 REMARK 465 ASN C 149 REMARK 465 LYS C 150 REMARK 465 SER C 151 REMARK 465 TRP C 152 REMARK 465 MET C 153 REMARK 465 GLU C 154 REMARK 465 SER C 155 REMARK 465 GLU C 156 REMARK 465 PHE C 157 REMARK 465 ARG C 158 REMARK 465 VAL C 159 REMARK 465 TYR C 160 REMARK 465 SER C 161 REMARK 465 SER C 162 REMARK 465 ALA C 163 REMARK 465 ASN C 164 REMARK 465 GLN C 173 REMARK 465 PRO C 174 REMARK 465 PHE C 175 REMARK 465 LEU C 176 REMARK 465 MET C 177 REMARK 465 ASP C 178 REMARK 465 LEU C 179 REMARK 465 GLU C 180 REMARK 465 GLY C 181 REMARK 465 LYS C 182 REMARK 465 GLN C 183 REMARK 465 GLY C 184 REMARK 465 ASN C 185 REMARK 465 ARG C 246 REMARK 465 SER C 247 REMARK 465 TYR C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 PRO C 251 REMARK 465 GLY C 252 REMARK 465 ASP C 253 REMARK 465 SER C 254 REMARK 465 SER C 255 REMARK 465 SER C 256 REMARK 465 GLY C 257 REMARK 465 TRP C 258 REMARK 465 THR C 259 REMARK 465 ALA C 260 REMARK 465 GLY C 261 REMARK 465 ALA C 262 REMARK 465 ALA C 623 REMARK 465 ILE C 624 REMARK 465 HIS C 625 REMARK 465 ALA C 626 REMARK 465 ASP C 627 REMARK 465 GLN C 628 REMARK 465 LEU C 629 REMARK 465 THR C 630 REMARK 465 PRO C 631 REMARK 465 THR C 632 REMARK 465 TRP C 633 REMARK 465 ARG C 634 REMARK 465 VAL C 635 REMARK 465 GLN C 680 REMARK 465 THR C 681 REMARK 465 ASN C 682 REMARK 465 SER C 683 REMARK 465 PRO C 684 REMARK 465 ALA C 685 REMARK 465 SER C 686 REMARK 465 VAL C 687 REMARK 465 ALA C 688 REMARK 465 LEU C 828 REMARK 465 ALA C 829 REMARK 465 ASP C 830 REMARK 465 ALA C 831 REMARK 465 GLY C 832 REMARK 465 PHE C 833 REMARK 465 ILE C 834 REMARK 465 LYS C 835 REMARK 465 GLN C 836 REMARK 465 TYR C 837 REMARK 465 GLY C 838 REMARK 465 ASP C 839 REMARK 465 CYS C 840 REMARK 465 LEU C 841 REMARK 465 GLY C 842 REMARK 465 ASP C 843 REMARK 465 ILE C 844 REMARK 465 ALA C 845 REMARK 465 ALA C 846 REMARK 465 ARG C 847 REMARK 465 ASP C 848 REMARK 465 LEU C 849 REMARK 465 ILE C 850 REMARK 465 CYS C 851 REMARK 465 ALA C 852 REMARK 465 GLN C 853 REMARK 465 PHE C 1148 REMARK 465 LYS C 1149 REMARK 465 GLU C 1150 REMARK 465 GLU C 1151 REMARK 465 LEU C 1152 REMARK 465 ASP C 1153 REMARK 465 LYS C 1154 REMARK 465 TYR C 1155 REMARK 465 PHE C 1156 REMARK 465 LYS C 1157 REMARK 465 ASN C 1158 REMARK 465 HIS C 1159 REMARK 465 THR C 1160 REMARK 465 SER C 1161 REMARK 465 PRO C 1162 REMARK 465 ASP C 1163 REMARK 465 VAL C 1164 REMARK 465 ASP C 1165 REMARK 465 LEU C 1166 REMARK 465 GLY C 1167 REMARK 465 ASP C 1168 REMARK 465 ILE C 1169 REMARK 465 SER C 1170 REMARK 465 GLY C 1171 REMARK 465 ILE C 1172 REMARK 465 ASN C 1173 REMARK 465 ALA C 1174 REMARK 465 SER C 1175 REMARK 465 VAL C 1176 REMARK 465 VAL C 1177 REMARK 465 ASN C 1178 REMARK 465 ILE C 1179 REMARK 465 GLN C 1180 REMARK 465 LYS C 1181 REMARK 465 GLU C 1182 REMARK 465 ILE C 1183 REMARK 465 ASP C 1184 REMARK 465 ARG C 1185 REMARK 465 LEU C 1186 REMARK 465 ASN C 1187 REMARK 465 GLU C 1188 REMARK 465 VAL C 1189 REMARK 465 ALA C 1190 REMARK 465 LYS C 1191 REMARK 465 ASN C 1192 REMARK 465 LEU C 1193 REMARK 465 ASN C 1194 REMARK 465 GLU C 1195 REMARK 465 SER C 1196 REMARK 465 LEU C 1197 REMARK 465 ILE C 1198 REMARK 465 ASP C 1199 REMARK 465 LEU C 1200 REMARK 465 GLN C 1201 REMARK 465 GLU C 1202 REMARK 465 LEU C 1203 REMARK 465 GLY C 1204 REMARK 465 LYS C 1205 REMARK 465 TYR C 1206 REMARK 465 GLU C 1207 REMARK 465 GLN C 1208 REMARK 465 TYR C 1209 REMARK 465 ILE C 1210 REMARK 465 LYS C 1211 REMARK 465 TRP C 1212 REMARK 465 PRO C 1213 REMARK 465 SER C 1214 REMARK 465 GLY C 1215 REMARK 465 ARG C 1216 REMARK 465 LEU C 1217 REMARK 465 VAL C 1218 REMARK 465 PRO C 1219 REMARK 465 ARG C 1220 REMARK 465 GLY C 1221 REMARK 465 SER C 1222 REMARK 465 PRO C 1223 REMARK 465 GLY C 1224 REMARK 465 SER C 1225 REMARK 465 GLY C 1226 REMARK 465 TYR C 1227 REMARK 465 ILE C 1228 REMARK 465 PRO C 1229 REMARK 465 GLU C 1230 REMARK 465 ALA C 1231 REMARK 465 PRO C 1232 REMARK 465 ARG C 1233 REMARK 465 ASP C 1234 REMARK 465 GLY C 1235 REMARK 465 GLN C 1236 REMARK 465 ALA C 1237 REMARK 465 TYR C 1238 REMARK 465 VAL C 1239 REMARK 465 ARG C 1240 REMARK 465 LYS C 1241 REMARK 465 ASP C 1242 REMARK 465 GLY C 1243 REMARK 465 GLU C 1244 REMARK 465 TRP C 1245 REMARK 465 VAL C 1246 REMARK 465 LEU C 1247 REMARK 465 LEU C 1248 REMARK 465 SER C 1249 REMARK 465 THR C 1250 REMARK 465 PHE C 1251 REMARK 465 LEU C 1252 REMARK 465 GLY C 1253 REMARK 465 HIS C 1254 REMARK 465 HIS C 1255 REMARK 465 HIS C 1256 REMARK 465 HIS C 1257 REMARK 465 HIS C 1258 REMARK 465 HIS C 1259 REMARK 465 GLY H 114 REMARK 465 GLN H 115 REMARK 465 PRO H 116 REMARK 465 LYS H 117 REMARK 465 ALA H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 ARG H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ASP H 217 REMARK 465 LYS H 218 REMARK 465 THR H 219 REMARK 465 HIS H 220 REMARK 465 ALA L 0 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 GLY M 114 REMARK 465 GLN M 115 REMARK 465 PRO M 116 REMARK 465 LYS M 117 REMARK 465 ALA M 118 REMARK 465 PRO M 119 REMARK 465 SER M 120 REMARK 465 VAL M 121 REMARK 465 PHE M 122 REMARK 465 PRO M 123 REMARK 465 LEU M 124 REMARK 465 ALA M 125 REMARK 465 PRO M 126 REMARK 465 SER M 127 REMARK 465 SER M 128 REMARK 465 LYS M 129 REMARK 465 SER M 130 REMARK 465 THR M 131 REMARK 465 SER M 132 REMARK 465 GLY M 133 REMARK 465 GLY M 134 REMARK 465 THR M 135 REMARK 465 ALA M 136 REMARK 465 ALA M 137 REMARK 465 LEU M 138 REMARK 465 GLY M 139 REMARK 465 CYS M 140 REMARK 465 LEU M 141 REMARK 465 VAL M 142 REMARK 465 LYS M 143 REMARK 465 ASP M 144 REMARK 465 TYR M 145 REMARK 465 PHE M 146 REMARK 465 PRO M 147 REMARK 465 GLU M 148 REMARK 465 PRO M 149 REMARK 465 VAL M 150 REMARK 465 THR M 151 REMARK 465 VAL M 152 REMARK 465 SER M 153 REMARK 465 TRP M 154 REMARK 465 ASN M 155 REMARK 465 SER M 156 REMARK 465 GLY M 157 REMARK 465 ALA M 158 REMARK 465 LEU M 159 REMARK 465 THR M 160 REMARK 465 SER M 161 REMARK 465 GLY M 162 REMARK 465 VAL M 163 REMARK 465 HIS M 164 REMARK 465 THR M 165 REMARK 465 PHE M 166 REMARK 465 PRO M 167 REMARK 465 ALA M 168 REMARK 465 VAL M 169 REMARK 465 LEU M 170 REMARK 465 GLN M 171 REMARK 465 SER M 172 REMARK 465 SER M 173 REMARK 465 GLY M 174 REMARK 465 LEU M 175 REMARK 465 TYR M 176 REMARK 465 SER M 177 REMARK 465 LEU M 178 REMARK 465 SER M 179 REMARK 465 SER M 180 REMARK 465 VAL M 181 REMARK 465 VAL M 182 REMARK 465 THR M 183 REMARK 465 VAL M 184 REMARK 465 PRO M 185 REMARK 465 SER M 186 REMARK 465 SER M 187 REMARK 465 SER M 188 REMARK 465 LEU M 189 REMARK 465 GLY M 190 REMARK 465 THR M 191 REMARK 465 GLN M 192 REMARK 465 THR M 193 REMARK 465 TYR M 194 REMARK 465 ILE M 195 REMARK 465 CYS M 196 REMARK 465 ASN M 197 REMARK 465 VAL M 198 REMARK 465 ASN M 199 REMARK 465 HIS M 200 REMARK 465 LYS M 201 REMARK 465 PRO M 202 REMARK 465 SER M 203 REMARK 465 ASN M 204 REMARK 465 THR M 205 REMARK 465 LYS M 206 REMARK 465 VAL M 207 REMARK 465 ASP M 208 REMARK 465 LYS M 209 REMARK 465 ARG M 210 REMARK 465 VAL M 211 REMARK 465 GLU M 212 REMARK 465 PRO M 213 REMARK 465 LYS M 214 REMARK 465 SER M 215 REMARK 465 CYS M 216 REMARK 465 ASP M 217 REMARK 465 LYS M 218 REMARK 465 THR M 219 REMARK 465 HIS M 220 REMARK 465 ALA N 0 REMARK 465 THR N 109 REMARK 465 VAL N 110 REMARK 465 ALA N 111 REMARK 465 ALA N 112 REMARK 465 PRO N 113 REMARK 465 SER N 114 REMARK 465 VAL N 115 REMARK 465 PHE N 116 REMARK 465 ILE N 117 REMARK 465 PHE N 118 REMARK 465 PRO N 119 REMARK 465 PRO N 120 REMARK 465 SER N 121 REMARK 465 ASP N 122 REMARK 465 GLU N 123 REMARK 465 GLN N 124 REMARK 465 LEU N 125 REMARK 465 LYS N 126 REMARK 465 SER N 127 REMARK 465 GLY N 128 REMARK 465 THR N 129 REMARK 465 ALA N 130 REMARK 465 SER N 131 REMARK 465 VAL N 132 REMARK 465 VAL N 133 REMARK 465 CYS N 134 REMARK 465 LEU N 135 REMARK 465 LEU N 136 REMARK 465 ASN N 137 REMARK 465 ASN N 138 REMARK 465 PHE N 139 REMARK 465 TYR N 140 REMARK 465 PRO N 141 REMARK 465 ARG N 142 REMARK 465 GLU N 143 REMARK 465 ALA N 144 REMARK 465 LYS N 145 REMARK 465 VAL N 146 REMARK 465 GLN N 147 REMARK 465 TRP N 148 REMARK 465 LYS N 149 REMARK 465 VAL N 150 REMARK 465 ASP N 151 REMARK 465 ASN N 152 REMARK 465 ALA N 153 REMARK 465 LEU N 154 REMARK 465 GLN N 155 REMARK 465 SER N 156 REMARK 465 GLY N 157 REMARK 465 ASN N 158 REMARK 465 SER N 159 REMARK 465 GLN N 160 REMARK 465 GLU N 161 REMARK 465 SER N 162 REMARK 465 VAL N 163 REMARK 465 THR N 164 REMARK 465 GLU N 165 REMARK 465 GLN N 166 REMARK 465 ASP N 167 REMARK 465 SER N 168 REMARK 465 LYS N 169 REMARK 465 ASP N 170 REMARK 465 SER N 171 REMARK 465 THR N 172 REMARK 465 TYR N 173 REMARK 465 SER N 174 REMARK 465 LEU N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 THR N 178 REMARK 465 LEU N 179 REMARK 465 THR N 180 REMARK 465 LEU N 181 REMARK 465 SER N 182 REMARK 465 LYS N 183 REMARK 465 ALA N 184 REMARK 465 ASP N 185 REMARK 465 TYR N 186 REMARK 465 GLU N 187 REMARK 465 LYS N 188 REMARK 465 HIS N 189 REMARK 465 LYS N 190 REMARK 465 VAL N 191 REMARK 465 TYR N 192 REMARK 465 ALA N 193 REMARK 465 CYS N 194 REMARK 465 GLU N 195 REMARK 465 VAL N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 GLN N 199 REMARK 465 GLY N 200 REMARK 465 LEU N 201 REMARK 465 SER N 202 REMARK 465 SER N 203 REMARK 465 PRO N 204 REMARK 465 VAL N 205 REMARK 465 THR N 206 REMARK 465 LYS N 207 REMARK 465 SER N 208 REMARK 465 PHE N 209 REMARK 465 ASN N 210 REMARK 465 ARG N 211 REMARK 465 GLY N 212 REMARK 465 GLU N 213 REMARK 465 CYS N 214 REMARK 465 GLY P 114 REMARK 465 GLN P 115 REMARK 465 PRO P 116 REMARK 465 LYS P 117 REMARK 465 ALA P 118 REMARK 465 PRO P 119 REMARK 465 SER P 120 REMARK 465 VAL P 121 REMARK 465 PHE P 122 REMARK 465 PRO P 123 REMARK 465 LEU P 124 REMARK 465 ALA P 125 REMARK 465 PRO P 126 REMARK 465 SER P 127 REMARK 465 SER P 128 REMARK 465 LYS P 129 REMARK 465 SER P 130 REMARK 465 THR P 131 REMARK 465 SER P 132 REMARK 465 GLY P 133 REMARK 465 GLY P 134 REMARK 465 THR P 135 REMARK 465 ALA P 136 REMARK 465 ALA P 137 REMARK 465 LEU P 138 REMARK 465 GLY P 139 REMARK 465 CYS P 140 REMARK 465 LEU P 141 REMARK 465 VAL P 142 REMARK 465 LYS P 143 REMARK 465 ASP P 144 REMARK 465 TYR P 145 REMARK 465 PHE P 146 REMARK 465 PRO P 147 REMARK 465 GLU P 148 REMARK 465 PRO P 149 REMARK 465 VAL P 150 REMARK 465 THR P 151 REMARK 465 VAL P 152 REMARK 465 SER P 153 REMARK 465 TRP P 154 REMARK 465 ASN P 155 REMARK 465 SER P 156 REMARK 465 GLY P 157 REMARK 465 ALA P 158 REMARK 465 LEU P 159 REMARK 465 THR P 160 REMARK 465 SER P 161 REMARK 465 GLY P 162 REMARK 465 VAL P 163 REMARK 465 HIS P 164 REMARK 465 THR P 165 REMARK 465 PHE P 166 REMARK 465 PRO P 167 REMARK 465 ALA P 168 REMARK 465 VAL P 169 REMARK 465 LEU P 170 REMARK 465 GLN P 171 REMARK 465 SER P 172 REMARK 465 SER P 173 REMARK 465 GLY P 174 REMARK 465 LEU P 175 REMARK 465 TYR P 176 REMARK 465 SER P 177 REMARK 465 LEU P 178 REMARK 465 SER P 179 REMARK 465 SER P 180 REMARK 465 VAL P 181 REMARK 465 VAL P 182 REMARK 465 THR P 183 REMARK 465 VAL P 184 REMARK 465 PRO P 185 REMARK 465 SER P 186 REMARK 465 SER P 187 REMARK 465 SER P 188 REMARK 465 LEU P 189 REMARK 465 GLY P 190 REMARK 465 THR P 191 REMARK 465 GLN P 192 REMARK 465 THR P 193 REMARK 465 TYR P 194 REMARK 465 ILE P 195 REMARK 465 CYS P 196 REMARK 465 ASN P 197 REMARK 465 VAL P 198 REMARK 465 ASN P 199 REMARK 465 HIS P 200 REMARK 465 LYS P 201 REMARK 465 PRO P 202 REMARK 465 SER P 203 REMARK 465 ASN P 204 REMARK 465 THR P 205 REMARK 465 LYS P 206 REMARK 465 VAL P 207 REMARK 465 ASP P 208 REMARK 465 LYS P 209 REMARK 465 ARG P 210 REMARK 465 VAL P 211 REMARK 465 GLU P 212 REMARK 465 PRO P 213 REMARK 465 LYS P 214 REMARK 465 SER P 215 REMARK 465 CYS P 216 REMARK 465 ASP P 217 REMARK 465 LYS P 218 REMARK 465 THR P 219 REMARK 465 HIS P 220 REMARK 465 ALA Q 0 REMARK 465 THR Q 109 REMARK 465 VAL Q 110 REMARK 465 ALA Q 111 REMARK 465 ALA Q 112 REMARK 465 PRO Q 113 REMARK 465 SER Q 114 REMARK 465 VAL Q 115 REMARK 465 PHE Q 116 REMARK 465 ILE Q 117 REMARK 465 PHE Q 118 REMARK 465 PRO Q 119 REMARK 465 PRO Q 120 REMARK 465 SER Q 121 REMARK 465 ASP Q 122 REMARK 465 GLU Q 123 REMARK 465 GLN Q 124 REMARK 465 LEU Q 125 REMARK 465 LYS Q 126 REMARK 465 SER Q 127 REMARK 465 GLY Q 128 REMARK 465 THR Q 129 REMARK 465 ALA Q 130 REMARK 465 SER Q 131 REMARK 465 VAL Q 132 REMARK 465 VAL Q 133 REMARK 465 CYS Q 134 REMARK 465 LEU Q 135 REMARK 465 LEU Q 136 REMARK 465 ASN Q 137 REMARK 465 ASN Q 138 REMARK 465 PHE Q 139 REMARK 465 TYR Q 140 REMARK 465 PRO Q 141 REMARK 465 ARG Q 142 REMARK 465 GLU Q 143 REMARK 465 ALA Q 144 REMARK 465 LYS Q 145 REMARK 465 VAL Q 146 REMARK 465 GLN Q 147 REMARK 465 TRP Q 148 REMARK 465 LYS Q 149 REMARK 465 VAL Q 150 REMARK 465 ASP Q 151 REMARK 465 ASN Q 152 REMARK 465 ALA Q 153 REMARK 465 LEU Q 154 REMARK 465 GLN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ASN Q 158 REMARK 465 SER Q 159 REMARK 465 GLN Q 160 REMARK 465 GLU Q 161 REMARK 465 SER Q 162 REMARK 465 VAL Q 163 REMARK 465 THR Q 164 REMARK 465 GLU Q 165 REMARK 465 GLN Q 166 REMARK 465 ASP Q 167 REMARK 465 SER Q 168 REMARK 465 LYS Q 169 REMARK 465 ASP Q 170 REMARK 465 SER Q 171 REMARK 465 THR Q 172 REMARK 465 TYR Q 173 REMARK 465 SER Q 174 REMARK 465 LEU Q 175 REMARK 465 SER Q 176 REMARK 465 SER Q 177 REMARK 465 THR Q 178 REMARK 465 LEU Q 179 REMARK 465 THR Q 180 REMARK 465 LEU Q 181 REMARK 465 SER Q 182 REMARK 465 LYS Q 183 REMARK 465 ALA Q 184 REMARK 465 ASP Q 185 REMARK 465 TYR Q 186 REMARK 465 GLU Q 187 REMARK 465 LYS Q 188 REMARK 465 HIS Q 189 REMARK 465 LYS Q 190 REMARK 465 VAL Q 191 REMARK 465 TYR Q 192 REMARK 465 ALA Q 193 REMARK 465 CYS Q 194 REMARK 465 GLU Q 195 REMARK 465 VAL Q 196 REMARK 465 THR Q 197 REMARK 465 HIS Q 198 REMARK 465 GLN Q 199 REMARK 465 GLY Q 200 REMARK 465 LEU Q 201 REMARK 465 SER Q 202 REMARK 465 SER Q 203 REMARK 465 PRO Q 204 REMARK 465 VAL Q 205 REMARK 465 THR Q 206 REMARK 465 LYS Q 207 REMARK 465 SER Q 208 REMARK 465 PHE Q 209 REMARK 465 ASN Q 210 REMARK 465 ARG Q 211 REMARK 465 GLY Q 212 REMARK 465 GLU Q 213 REMARK 465 CYS Q 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A 166 CA - CB - SG ANGL. DEV. = 10.3 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PRO A 82 -175.67 -69.36 REMARK 500 PHE A 86 -60.76 -94.76 REMARK 500 ASP A 111 29.84 -141.81 REMARK 500 CYS A 166 129.65 -170.47 REMARK 500 THR A 333 -116.92 54.11 REMARK 500 ASP A 428 30.19 -93.32 REMARK 500 THR A 470 48.04 37.07 REMARK 500 SER A 730 -168.55 -161.34 REMARK 500 ALA A 783 35.19 -98.62 REMARK 500 LYS A 795 59.96 -94.26 REMARK 500 SER A 884 -30.60 -131.81 REMARK 500 ARG A 983 -3.63 68.08 REMARK 500 LEU B 110 29.60 47.79 REMARK 500 THR B 333 -116.22 60.87 REMARK 500 THR B 470 47.85 37.55 REMARK 500 GLN B 564 -60.35 -93.63 REMARK 500 ALA B 783 50.32 -91.51 REMARK 500 ARG B 983 -0.40 65.33 REMARK 500 MET B1050 -178.12 -173.83 REMARK 500 PHE C 86 -60.49 -93.48 REMARK 500 SER C 112 -0.62 67.54 REMARK 500 ASP C 215 -173.07 -171.68 REMARK 500 ALA C 292 19.93 -143.42 REMARK 500 PHE C 338 -108.71 51.02 REMARK 500 ASP C 428 35.78 -99.02 REMARK 500 THR C 470 51.80 37.42 REMARK 500 GLN C 564 -61.06 -95.27 REMARK 500 ALA C 783 54.63 -92.88 REMARK 500 ASN C 919 30.72 -140.59 REMARK 500 ALA C 972 -169.40 -79.65 REMARK 500 MET C1050 -179.95 -170.99 REMARK 500 ASN C1108 15.48 -141.53 REMARK 500 SER L 30 -120.62 63.95 REMARK 500 GLU L 50 -3.29 70.29 REMARK 500 ALA L 51 -0.04 69.13 REMARK 500 VAL M 48 -60.49 -109.38 REMARK 500 PHE M 52A -3.63 70.38 REMARK 500 SER N 30 -122.39 49.50 REMARK 500 GLU N 50 10.62 59.89 REMARK 500 ALA N 51 -3.91 68.06 REMARK 500 SER N 52 -2.29 -142.76 REMARK 500 SER Q 30 -143.22 56.95 REMARK 500 SER Q 52 -2.68 -140.34 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-48349 RELATED DB: EMDB REMARK 900 STRUCTURE OF THE SARS-COV-2 SPIKE 6P IN COMPLEX WITH THE RABBIT M8B- REMARK 900 C9 FAB DBREF 9ML6 A 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9ML6 B 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9ML6 C 1 1213 UNP P0DTC2 SPIKE_SARS2 1 1213 DBREF 9ML6 H 2 220 PDB 9ML6 9ML6 2 220 DBREF 9ML6 L 0 214 PDB 9ML6 9ML6 0 214 DBREF 9ML6 M 2 220 PDB 9ML6 9ML6 2 220 DBREF 9ML6 N 0 214 PDB 9ML6 9ML6 0 214 DBREF 9ML6 P 2 220 PDB 9ML6 9ML6 2 220 DBREF 9ML6 Q 0 214 PDB 9ML6 9ML6 0 214 SEQADV 9ML6 A UNP P0DTC2 ARG 682 DELETION SEQADV 9ML6 A UNP P0DTC2 ARG 683 DELETION SEQADV 9ML6 A UNP P0DTC2 ARG 685 DELETION SEQADV 9ML6 PRO A 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9ML6 PRO A 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9ML6 PRO A 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9ML6 PRO A 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9ML6 PRO A 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9ML6 PRO A 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9ML6 SER A 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY A 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG A 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU A 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL A 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO A 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG A 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY A 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER A 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO A 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY A 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER A 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY A 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TYR A 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ILE A 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO A 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLU A 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ALA A 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO A 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG A 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ASP A 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY A 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLN A 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ALA A 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TYR A 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL A 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG A 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LYS A 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ASP A 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY A 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLU A 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TRP A 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL A 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU A 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU A 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER A 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 THR A 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PHE A 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU A 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY A 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS A 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS A 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS A 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS A 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS A 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS A 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 B UNP P0DTC2 ARG 682 DELETION SEQADV 9ML6 B UNP P0DTC2 ARG 683 DELETION SEQADV 9ML6 B UNP P0DTC2 ARG 685 DELETION SEQADV 9ML6 PRO B 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9ML6 PRO B 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9ML6 PRO B 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9ML6 PRO B 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9ML6 PRO B 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9ML6 PRO B 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9ML6 SER B 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY B 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG B 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU B 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL B 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO B 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG B 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY B 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER B 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO B 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY B 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER B 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY B 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TYR B 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ILE B 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO B 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLU B 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ALA B 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO B 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG B 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ASP B 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY B 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLN B 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ALA B 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TYR B 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL B 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG B 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LYS B 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ASP B 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY B 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLU B 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TRP B 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL B 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU B 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU B 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER B 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 THR B 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PHE B 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU B 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY B 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS B 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS B 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS B 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS B 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS B 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS B 1259 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 C UNP P0DTC2 ARG 682 DELETION SEQADV 9ML6 C UNP P0DTC2 ARG 683 DELETION SEQADV 9ML6 C UNP P0DTC2 ARG 685 DELETION SEQADV 9ML6 PRO C 817 UNP P0DTC2 PHE 817 ENGINEERED MUTATION SEQADV 9ML6 PRO C 892 UNP P0DTC2 ALA 892 ENGINEERED MUTATION SEQADV 9ML6 PRO C 899 UNP P0DTC2 ALA 899 ENGINEERED MUTATION SEQADV 9ML6 PRO C 942 UNP P0DTC2 ALA 942 ENGINEERED MUTATION SEQADV 9ML6 PRO C 986 UNP P0DTC2 LYS 986 ENGINEERED MUTATION SEQADV 9ML6 PRO C 987 UNP P0DTC2 VAL 987 ENGINEERED MUTATION SEQADV 9ML6 SER C 1214 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY C 1215 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG C 1216 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU C 1217 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL C 1218 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO C 1219 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG C 1220 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY C 1221 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER C 1222 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO C 1223 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY C 1224 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER C 1225 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY C 1226 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TYR C 1227 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ILE C 1228 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO C 1229 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLU C 1230 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ALA C 1231 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PRO C 1232 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG C 1233 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ASP C 1234 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY C 1235 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLN C 1236 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ALA C 1237 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TYR C 1238 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL C 1239 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ARG C 1240 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LYS C 1241 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 ASP C 1242 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY C 1243 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLU C 1244 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 TRP C 1245 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 VAL C 1246 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU C 1247 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU C 1248 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 SER C 1249 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 THR C 1250 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 PHE C 1251 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 LEU C 1252 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 GLY C 1253 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS C 1254 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS C 1255 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS C 1256 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS C 1257 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS C 1258 UNP P0DTC2 EXPRESSION TAG SEQADV 9ML6 HIS C 1259 UNP P0DTC2 EXPRESSION TAG SEQRES 1 A 1256 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 A 1256 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 A 1256 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 A 1256 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 A 1256 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 A 1256 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 A 1256 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 A 1256 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 A 1256 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 A 1256 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 A 1256 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 A 1256 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 A 1256 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 A 1256 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 A 1256 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 A 1256 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 A 1256 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 A 1256 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 A 1256 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 A 1256 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 A 1256 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 A 1256 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 A 1256 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 A 1256 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 A 1256 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 A 1256 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 A 1256 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 A 1256 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 A 1256 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 A 1256 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 A 1256 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 A 1256 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 A 1256 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 A 1256 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 A 1256 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 A 1256 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 A 1256 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 A 1256 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 A 1256 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 A 1256 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 A 1256 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 A 1256 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 A 1256 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 A 1256 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 A 1256 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 A 1256 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 A 1256 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 A 1256 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 A 1256 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 A 1256 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 A 1256 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 A 1256 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 A 1256 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 A 1256 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 A 1256 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 A 1256 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 A 1256 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 A 1256 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 A 1256 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 A 1256 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 A 1256 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 A 1256 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 A 1256 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 A 1256 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 A 1256 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 A 1256 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 A 1256 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 A 1256 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 A 1256 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 A 1256 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 A 1256 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 A 1256 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 A 1256 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 A 1256 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 A 1256 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 A 1256 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 A 1256 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 A 1256 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 A 1256 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 A 1256 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 A 1256 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 A 1256 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 A 1256 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 A 1256 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 A 1256 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 A 1256 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 A 1256 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 A 1256 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 A 1256 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 A 1256 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 A 1256 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 A 1256 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 A 1256 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 A 1256 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 A 1256 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 A 1256 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 A 1256 LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 B 1256 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 B 1256 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 B 1256 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 B 1256 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 B 1256 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 B 1256 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 B 1256 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 B 1256 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 B 1256 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 B 1256 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 B 1256 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 B 1256 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 B 1256 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 B 1256 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 B 1256 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 B 1256 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 B 1256 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 B 1256 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 B 1256 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 B 1256 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 B 1256 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 B 1256 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 B 1256 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 B 1256 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 B 1256 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 B 1256 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 B 1256 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 B 1256 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 B 1256 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 B 1256 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 B 1256 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 B 1256 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 B 1256 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 B 1256 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 B 1256 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 B 1256 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 B 1256 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 B 1256 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 B 1256 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 B 1256 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 B 1256 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 B 1256 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 B 1256 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 B 1256 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 B 1256 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 B 1256 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 B 1256 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 B 1256 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 B 1256 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 B 1256 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 B 1256 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 B 1256 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 B 1256 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 B 1256 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 B 1256 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 B 1256 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 B 1256 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 B 1256 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 B 1256 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 B 1256 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 B 1256 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 B 1256 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 B 1256 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 B 1256 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 B 1256 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 B 1256 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 B 1256 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 B 1256 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 B 1256 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 B 1256 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 B 1256 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 B 1256 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 B 1256 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 B 1256 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 B 1256 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 B 1256 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 B 1256 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 B 1256 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 B 1256 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 B 1256 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 B 1256 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 B 1256 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 B 1256 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 B 1256 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 B 1256 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 B 1256 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 B 1256 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 B 1256 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 B 1256 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 B 1256 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 B 1256 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 B 1256 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 B 1256 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 B 1256 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 B 1256 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 B 1256 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 B 1256 LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 C 1256 MET PHE VAL PHE LEU VAL LEU LEU PRO LEU VAL SER SER SEQRES 2 C 1256 GLN CYS VAL ASN LEU THR THR ARG THR GLN LEU PRO PRO SEQRES 3 C 1256 ALA TYR THR ASN SER PHE THR ARG GLY VAL TYR TYR PRO SEQRES 4 C 1256 ASP LYS VAL PHE ARG SER SER VAL LEU HIS SER THR GLN SEQRES 5 C 1256 ASP LEU PHE LEU PRO PHE PHE SER ASN VAL THR TRP PHE SEQRES 6 C 1256 HIS ALA ILE HIS VAL SER GLY THR ASN GLY THR LYS ARG SEQRES 7 C 1256 PHE ASP ASN PRO VAL LEU PRO PHE ASN ASP GLY VAL TYR SEQRES 8 C 1256 PHE ALA SER THR GLU LYS SER ASN ILE ILE ARG GLY TRP SEQRES 9 C 1256 ILE PHE GLY THR THR LEU ASP SER LYS THR GLN SER LEU SEQRES 10 C 1256 LEU ILE VAL ASN ASN ALA THR ASN VAL VAL ILE LYS VAL SEQRES 11 C 1256 CYS GLU PHE GLN PHE CYS ASN ASP PRO PHE LEU GLY VAL SEQRES 12 C 1256 TYR TYR HIS LYS ASN ASN LYS SER TRP MET GLU SER GLU SEQRES 13 C 1256 PHE ARG VAL TYR SER SER ALA ASN ASN CYS THR PHE GLU SEQRES 14 C 1256 TYR VAL SER GLN PRO PHE LEU MET ASP LEU GLU GLY LYS SEQRES 15 C 1256 GLN GLY ASN PHE LYS ASN LEU ARG GLU PHE VAL PHE LYS SEQRES 16 C 1256 ASN ILE ASP GLY TYR PHE LYS ILE TYR SER LYS HIS THR SEQRES 17 C 1256 PRO ILE ASN LEU VAL ARG ASP LEU PRO GLN GLY PHE SER SEQRES 18 C 1256 ALA LEU GLU PRO LEU VAL ASP LEU PRO ILE GLY ILE ASN SEQRES 19 C 1256 ILE THR ARG PHE GLN THR LEU LEU ALA LEU HIS ARG SER SEQRES 20 C 1256 TYR LEU THR PRO GLY ASP SER SER SER GLY TRP THR ALA SEQRES 21 C 1256 GLY ALA ALA ALA TYR TYR VAL GLY TYR LEU GLN PRO ARG SEQRES 22 C 1256 THR PHE LEU LEU LYS TYR ASN GLU ASN GLY THR ILE THR SEQRES 23 C 1256 ASP ALA VAL ASP CYS ALA LEU ASP PRO LEU SER GLU THR SEQRES 24 C 1256 LYS CYS THR LEU LYS SER PHE THR VAL GLU LYS GLY ILE SEQRES 25 C 1256 TYR GLN THR SER ASN PHE ARG VAL GLN PRO THR GLU SER SEQRES 26 C 1256 ILE VAL ARG PHE PRO ASN ILE THR ASN LEU CYS PRO PHE SEQRES 27 C 1256 GLY GLU VAL PHE ASN ALA THR ARG PHE ALA SER VAL TYR SEQRES 28 C 1256 ALA TRP ASN ARG LYS ARG ILE SER ASN CYS VAL ALA ASP SEQRES 29 C 1256 TYR SER VAL LEU TYR ASN SER ALA SER PHE SER THR PHE SEQRES 30 C 1256 LYS CYS TYR GLY VAL SER PRO THR LYS LEU ASN ASP LEU SEQRES 31 C 1256 CYS PHE THR ASN VAL TYR ALA ASP SER PHE VAL ILE ARG SEQRES 32 C 1256 GLY ASP GLU VAL ARG GLN ILE ALA PRO GLY GLN THR GLY SEQRES 33 C 1256 LYS ILE ALA ASP TYR ASN TYR LYS LEU PRO ASP ASP PHE SEQRES 34 C 1256 THR GLY CYS VAL ILE ALA TRP ASN SER ASN ASN LEU ASP SEQRES 35 C 1256 SER LYS VAL GLY GLY ASN TYR ASN TYR LEU TYR ARG LEU SEQRES 36 C 1256 PHE ARG LYS SER ASN LEU LYS PRO PHE GLU ARG ASP ILE SEQRES 37 C 1256 SER THR GLU ILE TYR GLN ALA GLY SER THR PRO CYS ASN SEQRES 38 C 1256 GLY VAL GLU GLY PHE ASN CYS TYR PHE PRO LEU GLN SER SEQRES 39 C 1256 TYR GLY PHE GLN PRO THR ASN GLY VAL GLY TYR GLN PRO SEQRES 40 C 1256 TYR ARG VAL VAL VAL LEU SER PHE GLU LEU LEU HIS ALA SEQRES 41 C 1256 PRO ALA THR VAL CYS GLY PRO LYS LYS SER THR ASN LEU SEQRES 42 C 1256 VAL LYS ASN LYS CYS VAL ASN PHE ASN PHE ASN GLY LEU SEQRES 43 C 1256 THR GLY THR GLY VAL LEU THR GLU SER ASN LYS LYS PHE SEQRES 44 C 1256 LEU PRO PHE GLN GLN PHE GLY ARG ASP ILE ALA ASP THR SEQRES 45 C 1256 THR ASP ALA VAL ARG ASP PRO GLN THR LEU GLU ILE LEU SEQRES 46 C 1256 ASP ILE THR PRO CYS SER PHE GLY GLY VAL SER VAL ILE SEQRES 47 C 1256 THR PRO GLY THR ASN THR SER ASN GLN VAL ALA VAL LEU SEQRES 48 C 1256 TYR GLN ASP VAL ASN CYS THR GLU VAL PRO VAL ALA ILE SEQRES 49 C 1256 HIS ALA ASP GLN LEU THR PRO THR TRP ARG VAL TYR SER SEQRES 50 C 1256 THR GLY SER ASN VAL PHE GLN THR ARG ALA GLY CYS LEU SEQRES 51 C 1256 ILE GLY ALA GLU HIS VAL ASN ASN SER TYR GLU CYS ASP SEQRES 52 C 1256 ILE PRO ILE GLY ALA GLY ILE CYS ALA SER TYR GLN THR SEQRES 53 C 1256 GLN THR ASN SER PRO ALA SER VAL ALA SER GLN SER ILE SEQRES 54 C 1256 ILE ALA TYR THR MET SER LEU GLY ALA GLU ASN SER VAL SEQRES 55 C 1256 ALA TYR SER ASN ASN SER ILE ALA ILE PRO THR ASN PHE SEQRES 56 C 1256 THR ILE SER VAL THR THR GLU ILE LEU PRO VAL SER MET SEQRES 57 C 1256 THR LYS THR SER VAL ASP CYS THR MET TYR ILE CYS GLY SEQRES 58 C 1256 ASP SER THR GLU CYS SER ASN LEU LEU LEU GLN TYR GLY SEQRES 59 C 1256 SER PHE CYS THR GLN LEU ASN ARG ALA LEU THR GLY ILE SEQRES 60 C 1256 ALA VAL GLU GLN ASP LYS ASN THR GLN GLU VAL PHE ALA SEQRES 61 C 1256 GLN VAL LYS GLN ILE TYR LYS THR PRO PRO ILE LYS ASP SEQRES 62 C 1256 PHE GLY GLY PHE ASN PHE SER GLN ILE LEU PRO ASP PRO SEQRES 63 C 1256 SER LYS PRO SER LYS ARG SER PRO ILE GLU ASP LEU LEU SEQRES 64 C 1256 PHE ASN LYS VAL THR LEU ALA ASP ALA GLY PHE ILE LYS SEQRES 65 C 1256 GLN TYR GLY ASP CYS LEU GLY ASP ILE ALA ALA ARG ASP SEQRES 66 C 1256 LEU ILE CYS ALA GLN LYS PHE ASN GLY LEU THR VAL LEU SEQRES 67 C 1256 PRO PRO LEU LEU THR ASP GLU MET ILE ALA GLN TYR THR SEQRES 68 C 1256 SER ALA LEU LEU ALA GLY THR ILE THR SER GLY TRP THR SEQRES 69 C 1256 PHE GLY ALA GLY PRO ALA LEU GLN ILE PRO PHE PRO MET SEQRES 70 C 1256 GLN MET ALA TYR ARG PHE ASN GLY ILE GLY VAL THR GLN SEQRES 71 C 1256 ASN VAL LEU TYR GLU ASN GLN LYS LEU ILE ALA ASN GLN SEQRES 72 C 1256 PHE ASN SER ALA ILE GLY LYS ILE GLN ASP SER LEU SER SEQRES 73 C 1256 SER THR PRO SER ALA LEU GLY LYS LEU GLN ASP VAL VAL SEQRES 74 C 1256 ASN GLN ASN ALA GLN ALA LEU ASN THR LEU VAL LYS GLN SEQRES 75 C 1256 LEU SER SER ASN PHE GLY ALA ILE SER SER VAL LEU ASN SEQRES 76 C 1256 ASP ILE LEU SER ARG LEU ASP PRO PRO GLU ALA GLU VAL SEQRES 77 C 1256 GLN ILE ASP ARG LEU ILE THR GLY ARG LEU GLN SER LEU SEQRES 78 C 1256 GLN THR TYR VAL THR GLN GLN LEU ILE ARG ALA ALA GLU SEQRES 79 C 1256 ILE ARG ALA SER ALA ASN LEU ALA ALA THR LYS MET SER SEQRES 80 C 1256 GLU CYS VAL LEU GLY GLN SER LYS ARG VAL ASP PHE CYS SEQRES 81 C 1256 GLY LYS GLY TYR HIS LEU MET SER PHE PRO GLN SER ALA SEQRES 82 C 1256 PRO HIS GLY VAL VAL PHE LEU HIS VAL THR TYR VAL PRO SEQRES 83 C 1256 ALA GLN GLU LYS ASN PHE THR THR ALA PRO ALA ILE CYS SEQRES 84 C 1256 HIS ASP GLY LYS ALA HIS PHE PRO ARG GLU GLY VAL PHE SEQRES 85 C 1256 VAL SER ASN GLY THR HIS TRP PHE VAL THR GLN ARG ASN SEQRES 86 C 1256 PHE TYR GLU PRO GLN ILE ILE THR THR ASP ASN THR PHE SEQRES 87 C 1256 VAL SER GLY ASN CYS ASP VAL VAL ILE GLY ILE VAL ASN SEQRES 88 C 1256 ASN THR VAL TYR ASP PRO LEU GLN PRO GLU LEU ASP SER SEQRES 89 C 1256 PHE LYS GLU GLU LEU ASP LYS TYR PHE LYS ASN HIS THR SEQRES 90 C 1256 SER PRO ASP VAL ASP LEU GLY ASP ILE SER GLY ILE ASN SEQRES 91 C 1256 ALA SER VAL VAL ASN ILE GLN LYS GLU ILE ASP ARG LEU SEQRES 92 C 1256 ASN GLU VAL ALA LYS ASN LEU ASN GLU SER LEU ILE ASP SEQRES 93 C 1256 LEU GLN GLU LEU GLY LYS TYR GLU GLN TYR ILE LYS TRP SEQRES 94 C 1256 PRO SER GLY ARG LEU VAL PRO ARG GLY SER PRO GLY SER SEQRES 95 C 1256 GLY TYR ILE PRO GLU ALA PRO ARG ASP GLY GLN ALA TYR SEQRES 96 C 1256 VAL ARG LYS ASP GLY GLU TRP VAL LEU LEU SER THR PHE SEQRES 97 C 1256 LEU GLY HIS HIS HIS HIS HIS HIS SEQRES 1 H 236 GLN SER LEU GLU GLU SER GLY GLY ASP LEU VAL LYS PRO SEQRES 2 H 236 GLY THR SER LEU THR LEU THR CYS THR ALA SER GLY PHE SEQRES 3 H 236 SER PHE SER HIS ASN TYR VAL MET CYS TRP VAL ARG GLN SEQRES 4 H 236 ALA PRO GLY LYS GLY LEU GLU CYS VAL ALA CYS ILE TYR SEQRES 5 H 236 PHE GLY PHE GLY ASP THR TYR TYR ALA SER TRP ALA LYS SEQRES 6 H 236 GLY ARG ILE THR ILE SER LYS THR SER SER THR THR VAL SEQRES 7 H 236 THR LEU GLN MET THR SER LEU THR ALA ALA ASP THR ALA SEQRES 8 H 236 THR TYR PHE CYS ALA ARG ALA LEU GLY TYR TYR ILE TYR SEQRES 9 H 236 GLY ASP ALA GLY ASP ILE TYR ILE ALA ASP TYR PHE LYS SEQRES 10 H 236 LEU TRP GLY PRO GLY THR LEU VAL THR VAL SER SER GLY SEQRES 11 H 236 GLN PRO LYS ALA PRO SER VAL PHE PRO LEU ALA PRO SER SEQRES 12 H 236 SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS SEQRES 13 H 236 LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER SEQRES 14 H 236 TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE SEQRES 15 H 236 PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SEQRES 16 H 236 SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN SEQRES 17 H 236 THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR SEQRES 18 H 236 LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS SEQRES 19 H 236 THR HIS SEQRES 1 L 217 ALA ASP ILE VAL MET THR GLN THR PRO ALA SER VAL GLU SEQRES 2 L 217 ALA ALA VAL GLY GLY THR VAL THR ILE LYS CYS GLN ALA SEQRES 3 L 217 SER GLN SER ILE SER LYS TYR LEU ALA TRP TYR GLN GLN SEQRES 4 L 217 LYS PRO GLY GLN PRO PRO LYS LEU LEU ILE PHE GLU ALA SEQRES 5 L 217 SER THR LEU GLU SER GLY VAL PRO SER ARG PHE LYS GLY SEQRES 6 L 217 ARG GLY SER GLY THR GLU PHE THR LEU THR ILE SER ASP SEQRES 7 L 217 LEU GLU CYS ALA ASP ALA ALA THR TYR TYR CYS GLN GLY SEQRES 8 L 217 TYR TYR TYR SER SER HIS SER TYR VAL PHE GLY GLY GLY SEQRES 9 L 217 THR GLU VAL VAL VAL LYS ARG THR VAL ALA ALA PRO SER SEQRES 10 L 217 VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER SEQRES 11 L 217 GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR SEQRES 12 L 217 PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA SEQRES 13 L 217 LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN SEQRES 14 L 217 ASP SER LYS ASP SER THR TYR SER LEU SER SER THR LEU SEQRES 15 L 217 THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR SEQRES 16 L 217 ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL SEQRES 17 L 217 THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 M 236 GLN SER LEU GLU GLU SER GLY GLY ASP LEU VAL LYS PRO SEQRES 2 M 236 GLY THR SER LEU THR LEU THR CYS THR ALA SER GLY PHE SEQRES 3 M 236 SER PHE SER HIS ASN TYR VAL MET CYS TRP VAL ARG GLN SEQRES 4 M 236 ALA PRO GLY LYS GLY LEU GLU CYS VAL ALA CYS ILE TYR SEQRES 5 M 236 PHE GLY PHE GLY ASP THR TYR TYR ALA SER TRP ALA LYS SEQRES 6 M 236 GLY ARG ILE THR ILE SER LYS THR SER SER THR THR VAL SEQRES 7 M 236 THR LEU GLN MET THR SER LEU THR ALA ALA ASP THR ALA SEQRES 8 M 236 THR TYR PHE CYS ALA ARG ALA LEU GLY TYR TYR ILE TYR SEQRES 9 M 236 GLY ASP ALA GLY ASP ILE TYR ILE ALA ASP TYR PHE LYS SEQRES 10 M 236 LEU TRP GLY PRO GLY THR LEU VAL THR VAL SER SER GLY SEQRES 11 M 236 GLN PRO LYS ALA PRO SER VAL PHE PRO LEU ALA PRO SER SEQRES 12 M 236 SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS SEQRES 13 M 236 LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER SEQRES 14 M 236 TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE SEQRES 15 M 236 PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SEQRES 16 M 236 SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN SEQRES 17 M 236 THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR SEQRES 18 M 236 LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS SEQRES 19 M 236 THR HIS SEQRES 1 N 217 ALA ASP ILE VAL MET THR GLN THR PRO ALA SER VAL GLU SEQRES 2 N 217 ALA ALA VAL GLY GLY THR VAL THR ILE LYS CYS GLN ALA SEQRES 3 N 217 SER GLN SER ILE SER LYS TYR LEU ALA TRP TYR GLN GLN SEQRES 4 N 217 LYS PRO GLY GLN PRO PRO LYS LEU LEU ILE PHE GLU ALA SEQRES 5 N 217 SER THR LEU GLU SER GLY VAL PRO SER ARG PHE LYS GLY SEQRES 6 N 217 ARG GLY SER GLY THR GLU PHE THR LEU THR ILE SER ASP SEQRES 7 N 217 LEU GLU CYS ALA ASP ALA ALA THR TYR TYR CYS GLN GLY SEQRES 8 N 217 TYR TYR TYR SER SER HIS SER TYR VAL PHE GLY GLY GLY SEQRES 9 N 217 THR GLU VAL VAL VAL LYS ARG THR VAL ALA ALA PRO SER SEQRES 10 N 217 VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER SEQRES 11 N 217 GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR SEQRES 12 N 217 PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA SEQRES 13 N 217 LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN SEQRES 14 N 217 ASP SER LYS ASP SER THR TYR SER LEU SER SER THR LEU SEQRES 15 N 217 THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR SEQRES 16 N 217 ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL SEQRES 17 N 217 THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 P 236 GLN SER LEU GLU GLU SER GLY GLY ASP LEU VAL LYS PRO SEQRES 2 P 236 GLY THR SER LEU THR LEU THR CYS THR ALA SER GLY PHE SEQRES 3 P 236 SER PHE SER HIS ASN TYR VAL MET CYS TRP VAL ARG GLN SEQRES 4 P 236 ALA PRO GLY LYS GLY LEU GLU CYS VAL ALA CYS ILE TYR SEQRES 5 P 236 PHE GLY PHE GLY ASP THR TYR TYR ALA SER TRP ALA LYS SEQRES 6 P 236 GLY ARG ILE THR ILE SER LYS THR SER SER THR THR VAL SEQRES 7 P 236 THR LEU GLN MET THR SER LEU THR ALA ALA ASP THR ALA SEQRES 8 P 236 THR TYR PHE CYS ALA ARG ALA LEU GLY TYR TYR ILE TYR SEQRES 9 P 236 GLY ASP ALA GLY ASP ILE TYR ILE ALA ASP TYR PHE LYS SEQRES 10 P 236 LEU TRP GLY PRO GLY THR LEU VAL THR VAL SER SER GLY SEQRES 11 P 236 GLN PRO LYS ALA PRO SER VAL PHE PRO LEU ALA PRO SER SEQRES 12 P 236 SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS SEQRES 13 P 236 LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER SEQRES 14 P 236 TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE SEQRES 15 P 236 PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SEQRES 16 P 236 SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN SEQRES 17 P 236 THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR SEQRES 18 P 236 LYS VAL ASP LYS ARG VAL GLU PRO LYS SER CYS ASP LYS SEQRES 19 P 236 THR HIS SEQRES 1 Q 217 ALA ASP ILE VAL MET THR GLN THR PRO ALA SER VAL GLU SEQRES 2 Q 217 ALA ALA VAL GLY GLY THR VAL THR ILE LYS CYS GLN ALA SEQRES 3 Q 217 SER GLN SER ILE SER LYS TYR LEU ALA TRP TYR GLN GLN SEQRES 4 Q 217 LYS PRO GLY GLN PRO PRO LYS LEU LEU ILE PHE GLU ALA SEQRES 5 Q 217 SER THR LEU GLU SER GLY VAL PRO SER ARG PHE LYS GLY SEQRES 6 Q 217 ARG GLY SER GLY THR GLU PHE THR LEU THR ILE SER ASP SEQRES 7 Q 217 LEU GLU CYS ALA ASP ALA ALA THR TYR TYR CYS GLN GLY SEQRES 8 Q 217 TYR TYR TYR SER SER HIS SER TYR VAL PHE GLY GLY GLY SEQRES 9 Q 217 THR GLU VAL VAL VAL LYS ARG THR VAL ALA ALA PRO SER SEQRES 10 Q 217 VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER SEQRES 11 Q 217 GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR SEQRES 12 Q 217 PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA SEQRES 13 Q 217 LEU GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN SEQRES 14 Q 217 ASP SER LYS ASP SER THR TYR SER LEU SER SER THR LEU SEQRES 15 Q 217 THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR SEQRES 16 Q 217 ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL SEQRES 17 Q 217 THR LYS SER PHE ASN ARG GLY GLU CYS HET NAG A1301 14 HET NAG A1302 14 HET NAG A1303 14 HET NAG A1304 14 HET NAG A1305 14 HET NAG A1306 14 HET NAG A1307 14 HET NAG A1308 14 HET NAG A1309 14 HET NAG A1310 14 HET NAG A1311 14 HET NAG A1312 14 HET NAG A1313 14 HET NAG A1314 14 HET NAG A1315 14 HET NAG B1301 14 HET NAG B1302 14 HET NAG B1303 14 HET NAG B1304 14 HET NAG B1305 14 HET NAG B1306 14 HET NAG B1307 14 HET NAG B1308 14 HET NAG B1309 14 HET NAG B1310 14 HET NAG B1311 14 HET NAG B1312 14 HET NAG B1313 14 HET NAG B1314 14 HET NAG B1315 14 HET NAG C1301 14 HET NAG C1302 14 HET NAG C1303 14 HET NAG C1304 14 HET NAG C1305 14 HET NAG C1306 14 HET NAG C1307 14 HET NAG C1308 14 HET NAG C1309 14 HET NAG C1310 14 HET NAG C1311 14 HET NAG C1312 14 HET NAG C1313 14 HET NAG C1314 14 HET NAG C1315 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 10 NAG 45(C8 H15 N O6) HELIX 1 AA1 ASP A 294 LYS A 304 1 11 HELIX 2 AA2 PHE A 338 ASN A 343 1 6 HELIX 3 AA3 TYR A 365 SER A 371 1 7 HELIX 4 AA4 THR A 385 ASP A 389 5 5 HELIX 5 AA5 ASP A 405 ILE A 410 5 6 HELIX 6 AA6 GLY A 416 ASN A 422 1 7 HELIX 7 AA7 SER A 438 SER A 443 1 6 HELIX 8 AA8 GLY A 502 TYR A 505 5 4 HELIX 9 AA9 ASN A 616 VAL A 620 5 5 HELIX 10 AB1 ASP A 737 CYS A 743 1 7 HELIX 11 AB2 THR A 747 LEU A 754 1 8 HELIX 12 AB3 TYR A 756 ALA A 783 1 28 HELIX 13 AB4 SER A 816 VAL A 826 1 11 HELIX 14 AB5 THR A 866 SER A 884 1 19 HELIX 15 AB6 TRP A 886 ALA A 890 5 5 HELIX 16 AB7 PRO A 897 ASN A 907 1 11 HELIX 17 AB8 GLY A 908 GLY A 910 5 3 HELIX 18 AB9 GLN A 913 GLU A 918 1 6 HELIX 19 AC1 ASN A 919 THR A 941 1 23 HELIX 20 AC2 LEU A 945 GLN A 965 1 21 HELIX 21 AC3 LEU A 966 SER A 968 5 3 HELIX 22 AC4 VAL A 976 SER A 982 1 7 HELIX 23 AC5 ASP A 985 VAL A 1033 1 49 HELIX 24 AC6 LEU A 1141 SER A 1147 1 7 HELIX 25 AC7 ASP B 294 LYS B 304 1 11 HELIX 26 AC8 PRO B 337 ASN B 343 1 7 HELIX 27 AC9 TYR B 365 SER B 371 1 7 HELIX 28 AD1 THR B 385 LEU B 390 5 6 HELIX 29 AD2 ASP B 405 ILE B 410 5 6 HELIX 30 AD3 GLY B 416 ASN B 422 1 7 HELIX 31 AD4 SER B 438 SER B 443 1 6 HELIX 32 AD5 ASP B 737 CYS B 743 1 7 HELIX 33 AD6 SER B 746 TYR B 756 1 11 HELIX 34 AD7 SER B 758 ALA B 783 1 26 HELIX 35 AD8 SER B 816 VAL B 826 1 11 HELIX 36 AD9 THR B 866 SER B 884 1 19 HELIX 37 AE1 PRO B 897 ILE B 909 1 13 HELIX 38 AE2 GLN B 913 GLU B 918 1 6 HELIX 39 AE3 ASN B 919 THR B 941 1 23 HELIX 40 AE4 LEU B 945 GLN B 965 1 21 HELIX 41 AE5 LEU B 966 SER B 968 5 3 HELIX 42 AE6 VAL B 976 SER B 982 1 7 HELIX 43 AE7 ASP B 985 VAL B 1033 1 49 HELIX 44 AE8 PRO B 1140 SER B 1147 1 8 HELIX 45 AE9 ASP C 294 LYS C 304 1 11 HELIX 46 AF1 PHE C 338 ASN C 343 1 6 HELIX 47 AF2 TYR C 365 SER C 371 1 7 HELIX 48 AF3 THR C 385 LEU C 390 1 6 HELIX 49 AF4 GLY C 404 ILE C 410 5 7 HELIX 50 AF5 GLY C 416 ASN C 422 1 7 HELIX 51 AF6 SER C 438 SER C 443 1 6 HELIX 52 AF7 SER C 746 LEU C 754 1 9 HELIX 53 AF8 SER C 758 ALA C 783 1 26 HELIX 54 AF9 SER C 816 VAL C 826 1 11 HELIX 55 AG1 THR C 866 SER C 884 1 19 HELIX 56 AG2 TRP C 886 ALA C 890 5 5 HELIX 57 AG3 PRO C 897 ILE C 909 1 13 HELIX 58 AG4 GLN C 913 GLU C 918 1 6 HELIX 59 AG5 ASN C 919 THR C 941 1 23 HELIX 60 AG6 PRO C 942 ALA C 944 5 3 HELIX 61 AG7 LEU C 945 SER C 968 1 24 HELIX 62 AG8 VAL C 976 SER C 982 1 7 HELIX 63 AG9 ASP C 985 VAL C 1033 1 49 HELIX 64 AH1 THR C 1116 ASP C 1118 5 3 HELIX 65 AH2 ASN C 1125 VAL C 1129 5 5 HELIX 66 AH3 LEU C 1141 SER C 1147 1 7 HELIX 67 AH4 THR H 83 THR H 87 5 5 HELIX 68 AH5 GLU L 79 ALA L 83 5 5 HELIX 69 AH6 THR M 83 THR M 87 5 5 HELIX 70 AH7 GLU N 79 ALA N 83 5 5 HELIX 71 AH8 THR P 83 THR P 87 5 5 HELIX 72 AH9 GLU Q 79 ALA Q 83 5 5 SHEET 1 AA1 7 TYR A 28 ASN A 30 0 SHEET 2 AA1 7 ASN A 61 PHE A 65 -1 O VAL A 62 N THR A 29 SHEET 3 AA1 7 TYR A 265 VAL A 267 -1 O VAL A 267 N THR A 63 SHEET 4 AA1 7 VAL A 90 GLU A 96 -1 N ALA A 93 O TYR A 266 SHEET 5 AA1 7 ASN A 188 ILE A 197 -1 O PHE A 194 N VAL A 90 SHEET 6 AA1 7 TYR A 200 LYS A 206 -1 O LYS A 202 N LYS A 195 SHEET 7 AA1 7 GLU A 224 VAL A 227 -1 O LEU A 226 N ILE A 203 SHEET 1 AA2 3 LEU A 48 HIS A 49 0 SHEET 2 AA2 3 GLN A 271 TYR A 279 -1 O LEU A 277 N HIS A 49 SHEET 3 AA2 3 GLN A 52 PHE A 55 -1 N PHE A 55 O GLN A 271 SHEET 1 AA3 3 LEU A 48 HIS A 49 0 SHEET 2 AA3 3 GLN A 271 TYR A 279 -1 O LEU A 277 N HIS A 49 SHEET 3 AA3 3 ILE A 285 ASP A 290 -1 O ASP A 287 N LYS A 278 SHEET 1 AA4 6 LEU A 84 PRO A 85 0 SHEET 2 AA4 6 ARG A 237 LEU A 241 -1 O PHE A 238 N LEU A 84 SHEET 3 AA4 6 GLY A 103 PHE A 106 -1 N ILE A 105 O GLN A 239 SHEET 4 AA4 6 LEU A 117 ASN A 121 -1 O ILE A 119 N TRP A 104 SHEET 5 AA4 6 VAL A 126 LYS A 129 -1 O LYS A 129 N LEU A 118 SHEET 6 AA4 6 GLU A 169 VAL A 171 -1 O TYR A 170 N ILE A 128 SHEET 1 AA5 5 GLY A 311 ARG A 319 0 SHEET 2 AA5 5 PHE A 592 THR A 599 -1 O GLY A 593 N PHE A 318 SHEET 3 AA5 5 ALA A 609 GLN A 613 -1 O ALA A 609 N ILE A 598 SHEET 4 AA5 5 GLY A 648 ILE A 651 -1 O CYS A 649 N TYR A 612 SHEET 5 AA5 5 VAL A 642 GLN A 644 -1 N PHE A 643 O LEU A 650 SHEET 1 AA6 5 SER A 325 ARG A 328 0 SHEET 2 AA6 5 CYS A 538 PHE A 543 1 O ASN A 540 N ILE A 326 SHEET 3 AA6 5 THR A 549 GLU A 554 -1 O GLY A 550 N VAL A 539 SHEET 4 AA6 5 ILE A 584 THR A 588 -1 O ASP A 586 N THR A 553 SHEET 5 AA6 5 ALA A 575 ARG A 577 -1 N VAL A 576 O LEU A 585 SHEET 1 AA7 7 ASN A 354 ILE A 358 0 SHEET 2 AA7 7 ASN A 394 ARG A 403 -1 O ALA A 397 N LYS A 356 SHEET 3 AA7 7 PRO A 507 GLU A 516 -1 O VAL A 510 N PHE A 400 SHEET 4 AA7 7 GLY A 431 ASN A 437 -1 N ILE A 434 O VAL A 511 SHEET 5 AA7 7 THR A 376 TYR A 380 -1 N LYS A 378 O VAL A 433 SHEET 6 AA7 7 TYR H 98 TYR H 100A-1 O TYR H 99 N CYS A 379 SHEET 7 AA7 7 ASP H 100F ILE H 100I-1 O ILE H 100I N TYR H 98 SHEET 1 AA8 2 LEU A 452 ARG A 454 0 SHEET 2 AA8 2 LEU A 492 SER A 494 -1 O GLN A 493 N TYR A 453 SHEET 1 AA9 2 TYR A 473 GLN A 474 0 SHEET 2 AA9 2 CYS A 488 TYR A 489 -1 O TYR A 489 N TYR A 473 SHEET 1 AB1 2 PHE A 565 GLY A 566 0 SHEET 2 AB1 2 VAL C 42 PHE C 43 1 O PHE C 43 N PHE A 565 SHEET 1 AB2 4 GLU A 654 VAL A 656 0 SHEET 2 AB2 4 SER A 691 THR A 696 1 O ILE A 692 N GLU A 654 SHEET 3 AB2 4 ILE A 670 GLN A 675 -1 N CYS A 671 O TYR A 695 SHEET 4 AB2 4 ILE A 664 GLY A 667 -1 N GLY A 667 O ILE A 670 SHEET 1 AB3 2 SER A 711 PRO A 715 0 SHEET 2 AB3 2 GLU A1072 THR A1076 -1 O LYS A1073 N ILE A 714 SHEET 1 AB4 3 PHE A 718 THR A 719 0 SHEET 2 AB4 3 GLY A1059 PRO A1069 -1 O VAL A1068 N THR A 719 SHEET 3 AB4 3 TYR A1047 MET A1050 -1 N MET A1050 O VAL A1065 SHEET 1 AB5 3 VAL A 722 PRO A 728 0 SHEET 2 AB5 3 GLY A1059 PRO A1069 -1 O VAL A1060 N LEU A 727 SHEET 3 AB5 3 PRO A1053 ALA A1056 -1 N GLN A1054 O VAL A1061 SHEET 1 AB6 4 THR A1120 VAL A1122 0 SHEET 2 AB6 4 ALA A1087 PRO A1090 -1 N PHE A1089 O PHE A1121 SHEET 3 AB6 4 ILE A1081 CYS A1082 -1 N ILE A1081 O HIS A1088 SHEET 4 AB6 4 VAL A1133 ASN A1134 1 O VAL A1133 N CYS A1082 SHEET 1 AB7 3 VAL A1094 SER A1097 0 SHEET 2 AB7 3 TRP A1102 THR A1105 -1 O PHE A1103 N VAL A1096 SHEET 3 AB7 3 GLN A1113 ILE A1114 -1 O GLN A1113 N VAL A1104 SHEET 1 AB8 8 TYR B 28 SER B 31 0 SHEET 2 AB8 8 SER B 60 TRP B 64 -1 O SER B 60 N SER B 31 SHEET 3 AB8 8 TYR B 265 TYR B 269 -1 O VAL B 267 N THR B 63 SHEET 4 AB8 8 VAL B 90 GLU B 96 -1 N TYR B 91 O GLY B 268 SHEET 5 AB8 8 ASN B 188 ILE B 197 -1 O PHE B 192 N PHE B 92 SHEET 6 AB8 8 TYR B 200 PRO B 209 -1 O TYR B 200 N ILE B 197 SHEET 7 AB8 8 ALA B 222 VAL B 227 -1 O LEU B 226 N ILE B 203 SHEET 8 AB8 8 VAL B 36 TYR B 37 1 N VAL B 36 O LEU B 223 SHEET 1 AB9 3 GLN B 52 PHE B 55 0 SHEET 2 AB9 3 GLN B 271 TYR B 279 -1 O ARG B 273 N ASP B 53 SHEET 3 AB9 3 ILE B 285 ASP B 290 -1 O ASP B 287 N LYS B 278 SHEET 1 AC1 5 VAL B 83 PRO B 85 0 SHEET 2 AC1 5 ARG B 237 THR B 240 -1 O PHE B 238 N LEU B 84 SHEET 3 AC1 5 GLY B 103 PHE B 106 -1 N ILE B 105 O GLN B 239 SHEET 4 AC1 5 LEU B 117 ASN B 121 -1 O ILE B 119 N TRP B 104 SHEET 5 AC1 5 VAL B 126 LYS B 129 -1 O VAL B 127 N VAL B 120 SHEET 1 AC2 5 GLY B 311 ARG B 319 0 SHEET 2 AC2 5 PHE B 592 THR B 599 -1 O GLY B 593 N PHE B 318 SHEET 3 AC2 5 VAL B 610 GLN B 613 -1 O GLN B 613 N GLY B 594 SHEET 4 AC2 5 GLY B 648 ILE B 651 -1 O ILE B 651 N VAL B 610 SHEET 5 AC2 5 VAL B 642 THR B 645 -1 N THR B 645 O GLY B 648 SHEET 1 AC3 5 SER B 325 ILE B 326 0 SHEET 2 AC3 5 CYS B 538 PHE B 541 1 O ASN B 540 N ILE B 326 SHEET 3 AC3 5 THR B 549 GLU B 554 -1 O GLY B 550 N VAL B 539 SHEET 4 AC3 5 ILE B 584 THR B 588 -1 O ASP B 586 N THR B 553 SHEET 5 AC3 5 ALA B 575 ARG B 577 -1 N VAL B 576 O LEU B 585 SHEET 1 AC4 5 ASN B 354 ILE B 358 0 SHEET 2 AC4 5 ASN B 394 ARG B 403 -1 O ALA B 397 N LYS B 356 SHEET 3 AC4 5 PRO B 507 GLU B 516 -1 O TYR B 508 N ILE B 402 SHEET 4 AC4 5 GLY B 431 ASN B 437 -1 N ILE B 434 O VAL B 511 SHEET 5 AC4 5 THR B 376 TYR B 380 -1 N LYS B 378 O VAL B 433 SHEET 1 AC5 2 LEU B 452 ARG B 454 0 SHEET 2 AC5 2 LEU B 492 SER B 494 -1 O GLN B 493 N TYR B 453 SHEET 1 AC6 2 TYR B 473 GLN B 474 0 SHEET 2 AC6 2 CYS B 488 TYR B 489 -1 O TYR B 489 N TYR B 473 SHEET 1 AC7 4 GLU B 654 HIS B 655 0 SHEET 2 AC7 4 SER B 691 THR B 696 1 O ILE B 692 N GLU B 654 SHEET 3 AC7 4 ILE B 670 GLN B 675 -1 N SER B 673 O ILE B 693 SHEET 4 AC7 4 ILE B 664 GLY B 667 -1 N ILE B 664 O ALA B 672 SHEET 1 AC8 3 SER B 711 PRO B 728 0 SHEET 2 AC8 3 GLY B1059 THR B1076 -1 O GLN B1071 N THR B 716 SHEET 3 AC8 3 TYR B1047 MET B1050 -1 N TYR B1047 O TYR B1067 SHEET 1 AC9 3 SER B 711 PRO B 728 0 SHEET 2 AC9 3 GLY B1059 THR B1076 -1 O GLN B1071 N THR B 716 SHEET 3 AC9 3 PRO B1053 ALA B1056 -1 N GLN B1054 O VAL B1061 SHEET 1 AD1 2 LYS B 733 THR B 734 0 SHEET 2 AD1 2 VAL B 860 LEU B 861 -1 O LEU B 861 N LYS B 733 SHEET 1 AD2 4 THR B1120 ASN B1125 0 SHEET 2 AD2 4 LYS B1086 PRO B1090 -1 N PHE B1089 O PHE B1121 SHEET 3 AD2 4 ILE B1081 CYS B1082 -1 O ILE B1081 N HIS B1088 SHEET 4 AD2 4 VAL B1133 ASN B1134 1 O VAL B1133 N CYS B1082 SHEET 1 AD3 3 VAL B1094 SER B1097 0 SHEET 2 AD3 3 TRP B1102 THR B1105 -1 O PHE B1103 N VAL B1096 SHEET 3 AD3 3 GLN B1113 ILE B1114 -1 O GLN B1113 N VAL B1104 SHEET 1 AD4 7 TYR C 28 ASN C 30 0 SHEET 2 AD4 7 ASN C 61 PHE C 65 -1 O VAL C 62 N THR C 29 SHEET 3 AD4 7 TYR C 265 GLY C 268 -1 O VAL C 267 N THR C 63 SHEET 4 AD4 7 VAL C 90 GLU C 96 -1 N ALA C 93 O TYR C 266 SHEET 5 AD4 7 ASN C 188 ILE C 197 -1 O PHE C 192 N PHE C 92 SHEET 6 AD4 7 TYR C 200 LYS C 206 -1 O LYS C 206 N GLU C 191 SHEET 7 AD4 7 GLU C 224 PRO C 230 -1 O GLU C 224 N SER C 205 SHEET 1 AD5 3 LEU C 48 PHE C 55 0 SHEET 2 AD5 3 GLN C 271 TYR C 279 -1 O GLN C 271 N PHE C 55 SHEET 3 AD5 3 ILE C 285 ASP C 287 -1 O ASP C 287 N LYS C 278 SHEET 1 AD6 6 LEU C 84 PRO C 85 0 SHEET 2 AD6 6 ARG C 237 LEU C 241 -1 O PHE C 238 N LEU C 84 SHEET 3 AD6 6 GLY C 103 PHE C 106 -1 N ILE C 105 O GLN C 239 SHEET 4 AD6 6 LEU C 117 ASN C 121 -1 O ILE C 119 N TRP C 104 SHEET 5 AD6 6 VAL C 126 LYS C 129 -1 O VAL C 127 N VAL C 120 SHEET 6 AD6 6 GLU C 169 TYR C 170 -1 O TYR C 170 N ILE C 128 SHEET 1 AD7 5 GLY C 311 ARG C 319 0 SHEET 2 AD7 5 PHE C 592 THR C 599 -1 O GLY C 593 N PHE C 318 SHEET 3 AD7 5 ALA C 609 GLN C 613 -1 O LEU C 611 N SER C 596 SHEET 4 AD7 5 GLY C 648 ILE C 651 -1 O ILE C 651 N VAL C 610 SHEET 5 AD7 5 VAL C 642 THR C 645 -1 N PHE C 643 O LEU C 650 SHEET 1 AD8 5 SER C 325 ARG C 328 0 SHEET 2 AD8 5 CYS C 538 PHE C 543 1 O ASN C 540 N ILE C 326 SHEET 3 AD8 5 GLY C 548 GLU C 554 -1 O GLY C 550 N VAL C 539 SHEET 4 AD8 5 LEU C 585 THR C 588 -1 O ASP C 586 N THR C 553 SHEET 5 AD8 5 ALA C 575 VAL C 576 -1 N VAL C 576 O LEU C 585 SHEET 1 AD9 5 ASN C 354 ILE C 358 0 SHEET 2 AD9 5 ASN C 394 ILE C 402 -1 O ALA C 397 N LYS C 356 SHEET 3 AD9 5 TYR C 508 GLU C 516 -1 O TYR C 508 N ILE C 402 SHEET 4 AD9 5 GLY C 431 ASN C 437 -1 N ILE C 434 O VAL C 511 SHEET 5 AD9 5 THR C 376 TYR C 380 -1 N LYS C 378 O VAL C 433 SHEET 1 AE1 2 CYS C 391 PHE C 392 0 SHEET 2 AE1 2 VAL C 524 CYS C 525 -1 O VAL C 524 N PHE C 392 SHEET 1 AE2 2 LEU C 452 ARG C 454 0 SHEET 2 AE2 2 LEU C 492 SER C 494 -1 O GLN C 493 N TYR C 453 SHEET 1 AE3 2 TYR C 473 GLN C 474 0 SHEET 2 AE3 2 CYS C 488 TYR C 489 -1 O TYR C 489 N TYR C 473 SHEET 1 AE4 4 ALA C 653 HIS C 655 0 SHEET 2 AE4 4 SER C 691 THR C 696 1 O ILE C 692 N GLU C 654 SHEET 3 AE4 4 ILE C 670 GLN C 675 -1 N SER C 673 O ILE C 693 SHEET 4 AE4 4 ILE C 664 GLY C 667 -1 N ILE C 664 O ALA C 672 SHEET 1 AE5 2 ILE C 712 PRO C 715 0 SHEET 2 AE5 2 GLU C1072 PHE C1075 -1 O LYS C1073 N ILE C 714 SHEET 1 AE6 3 PHE C 718 THR C 719 0 SHEET 2 AE6 3 GLY C1059 PRO C1069 -1 O VAL C1068 N THR C 719 SHEET 3 AE6 3 TYR C1047 MET C1050 -1 N LEU C1049 O VAL C1065 SHEET 1 AE7 3 VAL C 722 PRO C 728 0 SHEET 2 AE7 3 GLY C1059 PRO C1069 -1 O PHE C1062 N GLU C 725 SHEET 3 AE7 3 PRO C1053 ALA C1056 -1 N GLN C1054 O VAL C1061 SHEET 1 AE8 2 LYS C 733 VAL C 736 0 SHEET 2 AE8 2 LEU C 858 LEU C 861 -1 O LEU C 861 N LYS C 733 SHEET 1 AE9 2 ILE C1081 CYS C1082 0 SHEET 2 AE9 2 VAL C1133 ASN C1134 1 O VAL C1133 N CYS C1082 SHEET 1 AF1 2 HIS C1088 PRO C1090 0 SHEET 2 AF1 2 THR C1120 VAL C1122 -1 O PHE C1121 N PHE C1089 SHEET 1 AF2 3 VAL C1094 SER C1097 0 SHEET 2 AF2 3 TRP C1102 THR C1105 -1 O PHE C1103 N VAL C1096 SHEET 3 AF2 3 GLN C1113 ILE C1114 -1 O GLN C1113 N VAL C1104 SHEET 1 AF3 4 SER H 3 SER H 7 0 SHEET 2 AF3 4 LEU H 18 SER H 25 -1 O THR H 21 N SER H 7 SHEET 3 AF3 4 THR H 76 MET H 81 -1 O LEU H 79 N LEU H 20 SHEET 4 AF3 4 ILE H 67 SER H 73 -1 N SER H 70 O THR H 78 SHEET 1 AF4 6 LEU H 11 VAL H 12 0 SHEET 2 AF4 6 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AF4 6 ALA H 88 LEU H 96 -1 N ALA H 88 O VAL H 109 SHEET 4 AF4 6 TYR H 33 GLN H 39 -1 N VAL H 37 O PHE H 91 SHEET 5 AF4 6 LEU H 45 TYR H 52 -1 O VAL H 48 N TRP H 36 SHEET 6 AF4 6 THR H 57 TYR H 59 -1 O TYR H 58 N CYS H 50 SHEET 1 AF5 4 MET L 4 THR L 7 0 SHEET 2 AF5 4 VAL L 19 ALA L 25 -1 O GLN L 24 N THR L 5 SHEET 3 AF5 4 GLU L 70 ILE L 75 -1 O PHE L 71 N CYS L 23 SHEET 4 AF5 4 PHE L 62 SER L 67 -1 N ARG L 65 O THR L 72 SHEET 1 AF6 6 SER L 10 ALA L 13 0 SHEET 2 AF6 6 THR L 102 VAL L 106 1 O GLU L 103 N VAL L 11 SHEET 3 AF6 6 THR L 85 TYR L 92 -1 N TYR L 86 O THR L 102 SHEET 4 AF6 6 LEU L 33 GLN L 38 -1 N GLN L 38 O THR L 85 SHEET 5 AF6 6 LYS L 45 PHE L 49 -1 O LEU L 47 N TRP L 35 SHEET 6 AF6 6 THR L 53 LEU L 54 -1 O THR L 53 N PHE L 49 SHEET 1 AF7 4 SER L 10 ALA L 13 0 SHEET 2 AF7 4 THR L 102 VAL L 106 1 O GLU L 103 N VAL L 11 SHEET 3 AF7 4 THR L 85 TYR L 92 -1 N TYR L 86 O THR L 102 SHEET 4 AF7 4 SER L 95B PHE L 98 -1 O SER L 95B N TYR L 92 SHEET 1 AF8 4 SER M 3 SER M 7 0 SHEET 2 AF8 4 LEU M 18 SER M 25 -1 O THR M 23 N GLU M 5 SHEET 3 AF8 4 THR M 76 MET M 81 -1 O MET M 81 N LEU M 18 SHEET 4 AF8 4 ILE M 67 SER M 73 -1 N THR M 68 O GLN M 80 SHEET 1 AF9 6 LEU M 11 VAL M 12 0 SHEET 2 AF9 6 THR M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AF9 6 ALA M 88 LEU M 96 -1 N ALA M 88 O VAL M 109 SHEET 4 AF9 6 TYR M 33 GLN M 39 -1 N VAL M 37 O PHE M 91 SHEET 5 AF9 6 LEU M 45 ILE M 51 -1 O GLU M 46 N ARG M 38 SHEET 6 AF9 6 THR M 57 TYR M 59 -1 O TYR M 58 N CYS M 50 SHEET 1 AG1 4 LEU M 11 VAL M 12 0 SHEET 2 AG1 4 THR M 107 VAL M 111 1 O THR M 110 N VAL M 12 SHEET 3 AG1 4 ALA M 88 LEU M 96 -1 N ALA M 88 O VAL M 109 SHEET 4 AG1 4 LEU M 102 TRP M 103 -1 O LEU M 102 N ARG M 94 SHEET 1 AG2 2 TYR M 98 TYR M 100A 0 SHEET 2 AG2 2 ASP M 100F ILE M 100I-1 O ILE M 100G N ILE M 100 SHEET 1 AG3 4 MET N 4 THR N 7 0 SHEET 2 AG3 4 THR N 18 ALA N 25 -1 O GLN N 24 N THR N 5 SHEET 3 AG3 4 GLU N 70 SER N 76 -1 O PHE N 71 N CYS N 23 SHEET 4 AG3 4 PHE N 62 SER N 67 -1 N LYS N 63 O THR N 74 SHEET 1 AG4 6 SER N 10 ALA N 14 0 SHEET 2 AG4 6 THR N 102 LYS N 107 1 O GLU N 103 N VAL N 11 SHEET 3 AG4 6 THR N 85 TYR N 92 -1 N TYR N 86 O THR N 102 SHEET 4 AG4 6 LEU N 33 GLN N 38 -1 N TYR N 36 O TYR N 87 SHEET 5 AG4 6 LYS N 45 PHE N 49 -1 O LYS N 45 N GLN N 37 SHEET 6 AG4 6 THR N 53 LEU N 54 -1 O THR N 53 N PHE N 49 SHEET 1 AG5 4 SER N 10 ALA N 14 0 SHEET 2 AG5 4 THR N 102 LYS N 107 1 O GLU N 103 N VAL N 11 SHEET 3 AG5 4 THR N 85 TYR N 92 -1 N TYR N 86 O THR N 102 SHEET 4 AG5 4 SER N 95B PHE N 98 -1 O VAL N 97 N GLY N 90 SHEET 1 AG6 4 SER P 3 SER P 7 0 SHEET 2 AG6 4 LEU P 18 SER P 25 -1 O THR P 23 N GLU P 5 SHEET 3 AG6 4 THR P 76 MET P 81 -1 O LEU P 79 N LEU P 20 SHEET 4 AG6 4 ILE P 67 LYS P 71 -1 N THR P 68 O GLN P 80 SHEET 1 AG7 6 LEU P 11 VAL P 12 0 SHEET 2 AG7 6 THR P 107 VAL P 111 1 O THR P 110 N VAL P 12 SHEET 3 AG7 6 ALA P 88 LEU P 96 -1 N TYR P 90 O THR P 107 SHEET 4 AG7 6 TYR P 33 GLN P 39 -1 N VAL P 37 O PHE P 91 SHEET 5 AG7 6 LEU P 45 TYR P 52 -1 O VAL P 48 N TRP P 36 SHEET 6 AG7 6 THR P 57 TYR P 59 -1 O TYR P 58 N CYS P 50 SHEET 1 AG8 4 LEU P 11 VAL P 12 0 SHEET 2 AG8 4 THR P 107 VAL P 111 1 O THR P 110 N VAL P 12 SHEET 3 AG8 4 ALA P 88 LEU P 96 -1 N TYR P 90 O THR P 107 SHEET 4 AG8 4 PHE P 100M TRP P 103 -1 O LYS P 101 N ARG P 94 SHEET 1 AG9 2 TYR P 98 TYR P 100A 0 SHEET 2 AG9 2 ASP P 100F ILE P 100I-1 O ILE P 100I N TYR P 98 SHEET 1 AH1 4 MET Q 4 THR Q 7 0 SHEET 2 AH1 4 THR Q 18 ALA Q 25 -1 O GLN Q 24 N THR Q 5 SHEET 3 AH1 4 GLU Q 70 SER Q 76 -1 O ILE Q 75 N VAL Q 19 SHEET 4 AH1 4 PHE Q 62 ARG Q 65 -1 N LYS Q 63 O THR Q 74 SHEET 1 AH2 6 SER Q 10 ALA Q 13 0 SHEET 2 AH2 6 THR Q 102 VAL Q 106 1 O VAL Q 105 N VAL Q 11 SHEET 3 AH2 6 THR Q 85 TYR Q 92 -1 N TYR Q 86 O THR Q 102 SHEET 4 AH2 6 LEU Q 33 GLN Q 38 -1 N GLN Q 38 O THR Q 85 SHEET 5 AH2 6 LYS Q 45 PHE Q 49 -1 O LEU Q 47 N TRP Q 35 SHEET 6 AH2 6 THR Q 53 LEU Q 54 -1 O THR Q 53 N PHE Q 49 SHEET 1 AH3 4 SER Q 10 ALA Q 13 0 SHEET 2 AH3 4 THR Q 102 VAL Q 106 1 O VAL Q 105 N VAL Q 11 SHEET 3 AH3 4 THR Q 85 TYR Q 92 -1 N TYR Q 86 O THR Q 102 SHEET 4 AH3 4 SER Q 95B PHE Q 98 -1 O VAL Q 97 N GLY Q 90 SSBOND 1 CYS A 131 CYS A 166 1555 1555 2.04 SSBOND 2 CYS A 291 CYS A 301 1555 1555 2.03 SSBOND 3 CYS A 336 CYS A 361 1555 1555 2.03 SSBOND 4 CYS A 379 CYS A 432 1555 1555 2.03 SSBOND 5 CYS A 391 CYS A 525 1555 1555 2.03 SSBOND 6 CYS A 480 CYS A 488 1555 1555 2.03 SSBOND 7 CYS A 617 CYS A 649 1555 1555 2.03 SSBOND 8 CYS A 738 CYS A 760 1555 1555 2.04 SSBOND 9 CYS A 743 CYS A 749 1555 1555 2.03 SSBOND 10 CYS A 1032 CYS A 1043 1555 1555 2.03 SSBOND 11 CYS A 1082 CYS A 1126 1555 1555 2.03 SSBOND 12 CYS B 131 CYS B 166 1555 1555 2.03 SSBOND 13 CYS B 291 CYS B 301 1555 1555 2.03 SSBOND 14 CYS B 336 CYS B 361 1555 1555 2.03 SSBOND 15 CYS B 379 CYS B 432 1555 1555 2.03 SSBOND 16 CYS B 391 CYS B 525 1555 1555 2.03 SSBOND 17 CYS B 480 CYS B 488 1555 1555 2.03 SSBOND 18 CYS B 617 CYS B 649 1555 1555 2.03 SSBOND 19 CYS B 662 CYS B 671 1555 1555 2.03 SSBOND 20 CYS B 738 CYS B 760 1555 1555 2.03 SSBOND 21 CYS B 743 CYS B 749 1555 1555 2.03 SSBOND 22 CYS B 1032 CYS B 1043 1555 1555 2.03 SSBOND 23 CYS B 1082 CYS B 1126 1555 1555 2.03 SSBOND 24 CYS C 131 CYS C 166 1555 1555 2.03 SSBOND 25 CYS C 291 CYS C 301 1555 1555 2.03 SSBOND 26 CYS C 336 CYS C 361 1555 1555 2.03 SSBOND 27 CYS C 379 CYS C 432 1555 1555 2.03 SSBOND 28 CYS C 391 CYS C 525 1555 1555 2.04 SSBOND 29 CYS C 480 CYS C 488 1555 1555 2.03 SSBOND 30 CYS C 617 CYS C 649 1555 1555 2.03 SSBOND 31 CYS C 662 CYS C 671 1555 1555 2.03 SSBOND 32 CYS C 738 CYS C 760 1555 1555 2.03 SSBOND 33 CYS C 743 CYS C 749 1555 1555 2.03 SSBOND 34 CYS C 1032 CYS C 1043 1555 1555 2.03 SSBOND 35 CYS C 1082 CYS C 1126 1555 1555 2.03 SSBOND 36 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 37 CYS H 35A CYS H 50 1555 1555 2.03 SSBOND 38 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 39 CYS M 22 CYS M 92 1555 1555 2.03 SSBOND 40 CYS M 35A CYS M 50 1555 1555 2.03 SSBOND 41 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 42 CYS P 22 CYS P 92 1555 1555 2.03 SSBOND 43 CYS P 35A CYS P 50 1555 1555 2.03 SSBOND 44 CYS Q 23 CYS Q 88 1555 1555 2.03 LINK ND2 ASN A 61 C1 NAG A1301 1555 1555 1.44 LINK ND2 ASN A 165 C1 NAG A1302 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A1303 1555 1555 1.45 LINK ND2 ASN A 282 C1 NAG A1304 1555 1555 1.44 LINK ND2 ASN A 331 C1 NAG A1305 1555 1555 1.45 LINK ND2 ASN A 343 C1 NAG A1314 1555 1555 1.44 LINK ND2 ASN A 603 C1 NAG A1306 1555 1555 1.44 LINK ND2 ASN A 616 C1 NAG A1307 1555 1555 1.45 LINK ND2 ASN A 657 C1 NAG A1308 1555 1555 1.45 LINK ND2 ASN A 709 C1 NAG A1309 1555 1555 1.44 LINK ND2 ASN A 717 C1 NAG A1310 1555 1555 1.44 LINK ND2 ASN A 801 C1 NAG A1315 1555 1555 1.45 LINK ND2 ASN A1074 C1 NAG A1311 1555 1555 1.44 LINK ND2 ASN A1098 C1 NAG A1312 1555 1555 1.44 LINK ND2 ASN A1134 C1 NAG A1313 1555 1555 1.44 LINK ND2 ASN B 61 C1 NAG B1301 1555 1555 1.44 LINK ND2 ASN B 165 C1 NAG B1302 1555 1555 1.44 LINK ND2 ASN B 234 C1 NAG B1303 1555 1555 1.44 LINK ND2 ASN B 282 C1 NAG B1304 1555 1555 1.44 LINK ND2 ASN B 331 C1 NAG B1305 1555 1555 1.45 LINK ND2 ASN B 343 C1 NAG B1314 1555 1555 1.44 LINK ND2 ASN B 603 C1 NAG B1306 1555 1555 1.44 LINK ND2 ASN B 616 C1 NAG B1307 1555 1555 1.44 LINK ND2 ASN B 657 C1 NAG B1308 1555 1555 1.45 LINK ND2 ASN B 709 C1 NAG B1309 1555 1555 1.44 LINK ND2 ASN B 717 C1 NAG B1310 1555 1555 1.45 LINK ND2 ASN B 801 C1 NAG B1315 1555 1555 1.44 LINK ND2 ASN B1074 C1 NAG B1311 1555 1555 1.44 LINK ND2 ASN B1098 C1 NAG B1312 1555 1555 1.44 LINK ND2 ASN B1134 C1 NAG B1313 1555 1555 1.44 LINK ND2 ASN C 61 C1 NAG C1301 1555 1555 1.45 LINK ND2 ASN C 165 C1 NAG C1302 1555 1555 1.44 LINK ND2 ASN C 234 C1 NAG C1303 1555 1555 1.45 LINK ND2 ASN C 282 C1 NAG C1304 1555 1555 1.44 LINK ND2 ASN C 331 C1 NAG C1305 1555 1555 1.45 LINK ND2 ASN C 343 C1 NAG C1314 1555 1555 1.44 LINK ND2 ASN C 603 C1 NAG C1306 1555 1555 1.45 LINK ND2 ASN C 616 C1 NAG C1307 1555 1555 1.44 LINK ND2 ASN C 657 C1 NAG C1308 1555 1555 1.46 LINK ND2 ASN C 709 C1 NAG C1309 1555 1555 1.44 LINK ND2 ASN C 717 C1 NAG C1310 1555 1555 1.44 LINK ND2 ASN C 801 C1 NAG C1315 1555 1555 1.44 LINK ND2 ASN C1074 C1 NAG C1311 1555 1555 1.44 LINK ND2 ASN C1098 C1 NAG C1312 1555 1555 1.44 LINK ND2 ASN C1134 C1 NAG C1313 1555 1555 1.44 CISPEP 1 THR L 7 PRO L 8 0 -6.01 CISPEP 2 THR N 7 PRO N 8 0 -1.09 CISPEP 3 THR Q 7 PRO Q 8 0 -2.14 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000