HEADER VIRAL PROTEIN 19-DEC-24 9MLK TITLE POST-FUSION HERV-K ENVELOPE PROTEIN IN COMPLEX WITH KENV-4 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: KENV-4 FAB HEAVY CHAIN; COMPND 3 CHAIN: H, I, J; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: KENV-4 FAB LIGHT CHAIN; COMPND 7 CHAIN: L, M, N; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: TRANSMEMBRANE PROTEIN; COMPND 11 CHAIN: A, C, B; COMPND 12 SYNONYM: TM; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 3 ORGANISM_TAXID: 10090; SOURCE 4 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 8 ORGANISM_TAXID: 10090; SOURCE 9 EXPRESSION_SYSTEM: CRICETULUS GRISEUS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 10029; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_COMMON: HUMAN; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 GENE: ERVK-6, ERVK6; SOURCE 16 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS HUMAN ENDOGENOUS RETROVIRUS K; GLYCOPROTEIN; HERV-K; ENVELOPE; POST- KEYWDS 2 FUSION, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR C.SUN,J.SHEK,K.HASTIE,E.O.SAPHIRE REVDAT 1 30-JUL-25 9MLK 0 JRNL AUTH J.SHEK,C.SUN,K.HASTIE,E.O.SAPHIRE JRNL TITL HUMAN ENDOGENOUS RETROVIRUS HERV-K ENVELOPE GLYCOPROTEIN JRNL TITL 2 STRUCTURES IN PRE- AND POST-FUSION CONFORMATIONS BY CRYO-EM JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.84 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : EPU, CRYOSPARC, UCSF CHIMERAX, COOT, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, REMARK 3 CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : OTHER REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.840 REMARK 3 NUMBER OF PARTICLES : 143318 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9MLK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-JAN-25. REMARK 100 THE DEPOSITION ID IS D_1000291238. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HERV-K ENV POST-FUSION TM IN REMARK 245 COMPLEX WITH KENV-4 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.68 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : OTHER REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 7000.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, I, M, J, N, A, C, B REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER H 121 REMARK 465 THR H 122 REMARK 465 LYS H 123 REMARK 465 GLY H 124 REMARK 465 PRO H 125 REMARK 465 SER H 126 REMARK 465 VAL H 127 REMARK 465 PHE H 128 REMARK 465 PRO H 129 REMARK 465 LEU H 130 REMARK 465 ALA H 131 REMARK 465 PRO H 132 REMARK 465 SER H 133 REMARK 465 SER H 134 REMARK 465 LYS H 135 REMARK 465 SER H 136 REMARK 465 THR H 137 REMARK 465 SER H 138 REMARK 465 GLY H 139 REMARK 465 GLY H 140 REMARK 465 THR H 141 REMARK 465 ALA H 142 REMARK 465 ALA H 143 REMARK 465 LEU H 144 REMARK 465 GLY H 145 REMARK 465 CYS H 146 REMARK 465 LEU H 147 REMARK 465 VAL H 148 REMARK 465 LYS H 149 REMARK 465 ASP H 150 REMARK 465 TYR H 151 REMARK 465 PHE H 152 REMARK 465 PRO H 153 REMARK 465 GLU H 154 REMARK 465 PRO H 155 REMARK 465 VAL H 156 REMARK 465 THR H 157 REMARK 465 VAL H 158 REMARK 465 SER H 159 REMARK 465 TRP H 160 REMARK 465 ASN H 161 REMARK 465 SER H 162 REMARK 465 GLY H 163 REMARK 465 ALA H 164 REMARK 465 LEU H 165 REMARK 465 THR H 166 REMARK 465 SER H 167 REMARK 465 GLY H 168 REMARK 465 VAL H 169 REMARK 465 HIS H 170 REMARK 465 THR H 171 REMARK 465 PHE H 172 REMARK 465 PRO H 173 REMARK 465 ALA H 174 REMARK 465 VAL H 175 REMARK 465 LEU H 176 REMARK 465 GLN H 177 REMARK 465 SER H 178 REMARK 465 SER H 179 REMARK 465 GLY H 180 REMARK 465 LEU H 181 REMARK 465 TYR H 182 REMARK 465 SER H 183 REMARK 465 LEU H 184 REMARK 465 SER H 185 REMARK 465 SER H 186 REMARK 465 VAL H 187 REMARK 465 VAL H 188 REMARK 465 THR H 189 REMARK 465 VAL H 190 REMARK 465 PRO H 191 REMARK 465 SER H 192 REMARK 465 SER H 193 REMARK 465 SER H 194 REMARK 465 LEU H 195 REMARK 465 GLY H 196 REMARK 465 THR H 197 REMARK 465 GLN H 198 REMARK 465 THR H 199 REMARK 465 TYR H 200 REMARK 465 ILE H 201 REMARK 465 CYS H 202 REMARK 465 ASN H 203 REMARK 465 VAL H 204 REMARK 465 ASN H 205 REMARK 465 HIS H 206 REMARK 465 LYS H 207 REMARK 465 PRO H 208 REMARK 465 SER H 209 REMARK 465 ASN H 210 REMARK 465 THR H 211 REMARK 465 LYS H 212 REMARK 465 VAL H 213 REMARK 465 ASP H 214 REMARK 465 LYS H 215 REMARK 465 ARG H 216 REMARK 465 VAL H 217 REMARK 465 GLU H 218 REMARK 465 PRO H 219 REMARK 465 LYS H 220 REMARK 465 SER H 221 REMARK 465 CYS H 222 REMARK 465 ASP H 223 REMARK 465 LYS H 224 REMARK 465 THR H 225 REMARK 465 HIS H 226 REMARK 465 THR H 227 REMARK 465 CYS H 228 REMARK 465 PRO H 229 REMARK 465 PRO H 230 REMARK 465 CYS H 231 REMARK 465 PRO H 232 REMARK 465 ALA H 233 REMARK 465 PRO H 234 REMARK 465 GLU H 235 REMARK 465 LEU H 236 REMARK 465 LEU H 237 REMARK 465 GLY H 238 REMARK 465 GLY H 239 REMARK 465 PRO H 240 REMARK 465 SER H 241 REMARK 465 VAL H 242 REMARK 465 PHE H 243 REMARK 465 LEU H 244 REMARK 465 PHE H 245 REMARK 465 PRO H 246 REMARK 465 PRO H 247 REMARK 465 LYS H 248 REMARK 465 PRO H 249 REMARK 465 LYS H 250 REMARK 465 ASP H 251 REMARK 465 THR H 252 REMARK 465 LEU H 253 REMARK 465 MET H 254 REMARK 465 ILE H 255 REMARK 465 SER H 256 REMARK 465 ARG H 257 REMARK 465 THR H 258 REMARK 465 PRO H 259 REMARK 465 GLU H 260 REMARK 465 VAL H 261 REMARK 465 THR H 262 REMARK 465 CYS H 263 REMARK 465 VAL H 264 REMARK 465 VAL H 265 REMARK 465 VAL H 266 REMARK 465 ASP H 267 REMARK 465 VAL H 268 REMARK 465 SER H 269 REMARK 465 HIS H 270 REMARK 465 GLU H 271 REMARK 465 ASP H 272 REMARK 465 PRO H 273 REMARK 465 GLU H 274 REMARK 465 VAL H 275 REMARK 465 LYS H 276 REMARK 465 PHE H 277 REMARK 465 ASN H 278 REMARK 465 TRP H 279 REMARK 465 TYR H 280 REMARK 465 VAL H 281 REMARK 465 ASP H 282 REMARK 465 GLY H 283 REMARK 465 VAL H 284 REMARK 465 GLU H 285 REMARK 465 VAL H 286 REMARK 465 HIS H 287 REMARK 465 ASN H 288 REMARK 465 ALA H 289 REMARK 465 LYS H 290 REMARK 465 THR H 291 REMARK 465 LYS H 292 REMARK 465 PRO H 293 REMARK 465 ARG H 294 REMARK 465 GLU H 295 REMARK 465 GLU H 296 REMARK 465 GLN H 297 REMARK 465 TYR H 298 REMARK 465 ASN H 299 REMARK 465 SER H 300 REMARK 465 THR H 301 REMARK 465 TYR H 302 REMARK 465 ARG H 303 REMARK 465 VAL H 304 REMARK 465 VAL H 305 REMARK 465 SER H 306 REMARK 465 VAL H 307 REMARK 465 LEU H 308 REMARK 465 THR H 309 REMARK 465 VAL H 310 REMARK 465 LEU H 311 REMARK 465 HIS H 312 REMARK 465 GLN H 313 REMARK 465 ASP H 314 REMARK 465 TRP H 315 REMARK 465 LEU H 316 REMARK 465 ASN H 317 REMARK 465 GLY H 318 REMARK 465 LYS H 319 REMARK 465 GLU H 320 REMARK 465 TYR H 321 REMARK 465 LYS H 322 REMARK 465 CYS H 323 REMARK 465 LYS H 324 REMARK 465 VAL H 325 REMARK 465 SER H 326 REMARK 465 ASN H 327 REMARK 465 LYS H 328 REMARK 465 ALA H 329 REMARK 465 LEU H 330 REMARK 465 PRO H 331 REMARK 465 ALA H 332 REMARK 465 PRO H 333 REMARK 465 ILE H 334 REMARK 465 GLU H 335 REMARK 465 LYS H 336 REMARK 465 THR H 337 REMARK 465 ILE H 338 REMARK 465 SER H 339 REMARK 465 LYS H 340 REMARK 465 ALA H 341 REMARK 465 LYS H 342 REMARK 465 GLY H 343 REMARK 465 GLN H 344 REMARK 465 PRO H 345 REMARK 465 ARG H 346 REMARK 465 GLU H 347 REMARK 465 PRO H 348 REMARK 465 GLN H 349 REMARK 465 VAL H 350 REMARK 465 TYR H 351 REMARK 465 THR H 352 REMARK 465 LEU H 353 REMARK 465 PRO H 354 REMARK 465 PRO H 355 REMARK 465 SER H 356 REMARK 465 ARG H 357 REMARK 465 GLU H 358 REMARK 465 GLU H 359 REMARK 465 MET H 360 REMARK 465 THR H 361 REMARK 465 LYS H 362 REMARK 465 ASN H 363 REMARK 465 GLN H 364 REMARK 465 VAL H 365 REMARK 465 SER H 366 REMARK 465 LEU H 367 REMARK 465 THR H 368 REMARK 465 CYS H 369 REMARK 465 LEU H 370 REMARK 465 VAL H 371 REMARK 465 LYS H 372 REMARK 465 GLY H 373 REMARK 465 PHE H 374 REMARK 465 TYR H 375 REMARK 465 PRO H 376 REMARK 465 SER H 377 REMARK 465 ASP H 378 REMARK 465 ILE H 379 REMARK 465 ALA H 380 REMARK 465 VAL H 381 REMARK 465 GLU H 382 REMARK 465 TRP H 383 REMARK 465 GLU H 384 REMARK 465 SER H 385 REMARK 465 ASN H 386 REMARK 465 GLY H 387 REMARK 465 GLN H 388 REMARK 465 PRO H 389 REMARK 465 GLU H 390 REMARK 465 ASN H 391 REMARK 465 ASN H 392 REMARK 465 TYR H 393 REMARK 465 LYS H 394 REMARK 465 THR H 395 REMARK 465 THR H 396 REMARK 465 PRO H 397 REMARK 465 PRO H 398 REMARK 465 VAL H 399 REMARK 465 LEU H 400 REMARK 465 ASP H 401 REMARK 465 SER H 402 REMARK 465 ASP H 403 REMARK 465 GLY H 404 REMARK 465 SER H 405 REMARK 465 PHE H 406 REMARK 465 PHE H 407 REMARK 465 LEU H 408 REMARK 465 TYR H 409 REMARK 465 SER H 410 REMARK 465 LYS H 411 REMARK 465 LEU H 412 REMARK 465 THR H 413 REMARK 465 VAL H 414 REMARK 465 ASP H 415 REMARK 465 LYS H 416 REMARK 465 SER H 417 REMARK 465 ARG H 418 REMARK 465 TRP H 419 REMARK 465 GLN H 420 REMARK 465 GLN H 421 REMARK 465 GLY H 422 REMARK 465 ASN H 423 REMARK 465 VAL H 424 REMARK 465 PHE H 425 REMARK 465 SER H 426 REMARK 465 CYS H 427 REMARK 465 SER H 428 REMARK 465 VAL H 429 REMARK 465 MET H 430 REMARK 465 HIS H 431 REMARK 465 GLU H 432 REMARK 465 ALA H 433 REMARK 465 LEU H 434 REMARK 465 HIS H 435 REMARK 465 ASN H 436 REMARK 465 HIS H 437 REMARK 465 TYR H 438 REMARK 465 THR H 439 REMARK 465 GLN H 440 REMARK 465 LYS H 441 REMARK 465 SER H 442 REMARK 465 LEU H 443 REMARK 465 SER H 444 REMARK 465 LEU H 445 REMARK 465 SER H 446 REMARK 465 PRO H 447 REMARK 465 GLY H 448 REMARK 465 LYS H 449 REMARK 465 ARG L 107 REMARK 465 THR L 108 REMARK 465 VAL L 109 REMARK 465 ALA L 110 REMARK 465 ALA L 111 REMARK 465 PRO L 112 REMARK 465 SER L 113 REMARK 465 VAL L 114 REMARK 465 PHE L 115 REMARK 465 ILE L 116 REMARK 465 PHE L 117 REMARK 465 PRO L 118 REMARK 465 PRO L 119 REMARK 465 SER L 120 REMARK 465 ASP L 121 REMARK 465 GLU L 122 REMARK 465 GLN L 123 REMARK 465 LEU L 124 REMARK 465 LYS L 125 REMARK 465 SER L 126 REMARK 465 GLY L 127 REMARK 465 THR L 128 REMARK 465 ALA L 129 REMARK 465 SER L 130 REMARK 465 VAL L 131 REMARK 465 VAL L 132 REMARK 465 CYS L 133 REMARK 465 LEU L 134 REMARK 465 LEU L 135 REMARK 465 ASN L 136 REMARK 465 ASN L 137 REMARK 465 PHE L 138 REMARK 465 TYR L 139 REMARK 465 PRO L 140 REMARK 465 ARG L 141 REMARK 465 GLU L 142 REMARK 465 ALA L 143 REMARK 465 LYS L 144 REMARK 465 VAL L 145 REMARK 465 GLN L 146 REMARK 465 TRP L 147 REMARK 465 LYS L 148 REMARK 465 VAL L 149 REMARK 465 ASP L 150 REMARK 465 ASN L 151 REMARK 465 ALA L 152 REMARK 465 LEU L 153 REMARK 465 GLN L 154 REMARK 465 SER L 155 REMARK 465 GLY L 156 REMARK 465 ASN L 157 REMARK 465 SER L 158 REMARK 465 GLN L 159 REMARK 465 GLU L 160 REMARK 465 SER L 161 REMARK 465 VAL L 162 REMARK 465 THR L 163 REMARK 465 GLU L 164 REMARK 465 GLN L 165 REMARK 465 ASP L 166 REMARK 465 SER L 167 REMARK 465 LYS L 168 REMARK 465 ASP L 169 REMARK 465 SER L 170 REMARK 465 THR L 171 REMARK 465 TYR L 172 REMARK 465 SER L 173 REMARK 465 LEU L 174 REMARK 465 SER L 175 REMARK 465 SER L 176 REMARK 465 THR L 177 REMARK 465 LEU L 178 REMARK 465 THR L 179 REMARK 465 LEU L 180 REMARK 465 SER L 181 REMARK 465 LYS L 182 REMARK 465 ALA L 183 REMARK 465 ASP L 184 REMARK 465 TYR L 185 REMARK 465 GLU L 186 REMARK 465 LYS L 187 REMARK 465 HIS L 188 REMARK 465 LYS L 189 REMARK 465 VAL L 190 REMARK 465 TYR L 191 REMARK 465 ALA L 192 REMARK 465 CYS L 193 REMARK 465 GLU L 194 REMARK 465 VAL L 195 REMARK 465 THR L 196 REMARK 465 HIS L 197 REMARK 465 GLN L 198 REMARK 465 GLY L 199 REMARK 465 LEU L 200 REMARK 465 SER L 201 REMARK 465 SER L 202 REMARK 465 PRO L 203 REMARK 465 VAL L 204 REMARK 465 THR L 205 REMARK 465 LYS L 206 REMARK 465 SER L 207 REMARK 465 PHE L 208 REMARK 465 ASN L 209 REMARK 465 ARG L 210 REMARK 465 GLY L 211 REMARK 465 GLU L 212 REMARK 465 CYS L 213 REMARK 465 THR I 122 REMARK 465 LYS I 123 REMARK 465 GLY I 124 REMARK 465 PRO I 125 REMARK 465 SER I 126 REMARK 465 VAL I 127 REMARK 465 PHE I 128 REMARK 465 PRO I 129 REMARK 465 LEU I 130 REMARK 465 ALA I 131 REMARK 465 PRO I 132 REMARK 465 SER I 133 REMARK 465 SER I 134 REMARK 465 LYS I 135 REMARK 465 SER I 136 REMARK 465 THR I 137 REMARK 465 SER I 138 REMARK 465 GLY I 139 REMARK 465 GLY I 140 REMARK 465 THR I 141 REMARK 465 ALA I 142 REMARK 465 ALA I 143 REMARK 465 LEU I 144 REMARK 465 GLY I 145 REMARK 465 CYS I 146 REMARK 465 LEU I 147 REMARK 465 VAL I 148 REMARK 465 LYS I 149 REMARK 465 ASP I 150 REMARK 465 TYR I 151 REMARK 465 PHE I 152 REMARK 465 PRO I 153 REMARK 465 GLU I 154 REMARK 465 PRO I 155 REMARK 465 VAL I 156 REMARK 465 THR I 157 REMARK 465 VAL I 158 REMARK 465 SER I 159 REMARK 465 TRP I 160 REMARK 465 ASN I 161 REMARK 465 SER I 162 REMARK 465 GLY I 163 REMARK 465 ALA I 164 REMARK 465 LEU I 165 REMARK 465 THR I 166 REMARK 465 SER I 167 REMARK 465 GLY I 168 REMARK 465 VAL I 169 REMARK 465 HIS I 170 REMARK 465 THR I 171 REMARK 465 PHE I 172 REMARK 465 PRO I 173 REMARK 465 ALA I 174 REMARK 465 VAL I 175 REMARK 465 LEU I 176 REMARK 465 GLN I 177 REMARK 465 SER I 178 REMARK 465 SER I 179 REMARK 465 GLY I 180 REMARK 465 LEU I 181 REMARK 465 TYR I 182 REMARK 465 SER I 183 REMARK 465 LEU I 184 REMARK 465 SER I 185 REMARK 465 SER I 186 REMARK 465 VAL I 187 REMARK 465 VAL I 188 REMARK 465 THR I 189 REMARK 465 VAL I 190 REMARK 465 PRO I 191 REMARK 465 SER I 192 REMARK 465 SER I 193 REMARK 465 SER I 194 REMARK 465 LEU I 195 REMARK 465 GLY I 196 REMARK 465 THR I 197 REMARK 465 GLN I 198 REMARK 465 THR I 199 REMARK 465 TYR I 200 REMARK 465 ILE I 201 REMARK 465 CYS I 202 REMARK 465 ASN I 203 REMARK 465 VAL I 204 REMARK 465 ASN I 205 REMARK 465 HIS I 206 REMARK 465 LYS I 207 REMARK 465 PRO I 208 REMARK 465 SER I 209 REMARK 465 ASN I 210 REMARK 465 THR I 211 REMARK 465 LYS I 212 REMARK 465 VAL I 213 REMARK 465 ASP I 214 REMARK 465 LYS I 215 REMARK 465 ARG I 216 REMARK 465 VAL I 217 REMARK 465 GLU I 218 REMARK 465 PRO I 219 REMARK 465 LYS I 220 REMARK 465 SER I 221 REMARK 465 CYS I 222 REMARK 465 ASP I 223 REMARK 465 LYS I 224 REMARK 465 THR I 225 REMARK 465 HIS I 226 REMARK 465 THR I 227 REMARK 465 CYS I 228 REMARK 465 PRO I 229 REMARK 465 PRO I 230 REMARK 465 CYS I 231 REMARK 465 PRO I 232 REMARK 465 ALA I 233 REMARK 465 PRO I 234 REMARK 465 GLU I 235 REMARK 465 LEU I 236 REMARK 465 LEU I 237 REMARK 465 GLY I 238 REMARK 465 GLY I 239 REMARK 465 PRO I 240 REMARK 465 SER I 241 REMARK 465 VAL I 242 REMARK 465 PHE I 243 REMARK 465 LEU I 244 REMARK 465 PHE I 245 REMARK 465 PRO I 246 REMARK 465 PRO I 247 REMARK 465 LYS I 248 REMARK 465 PRO I 249 REMARK 465 LYS I 250 REMARK 465 ASP I 251 REMARK 465 THR I 252 REMARK 465 LEU I 253 REMARK 465 MET I 254 REMARK 465 ILE I 255 REMARK 465 SER I 256 REMARK 465 ARG I 257 REMARK 465 THR I 258 REMARK 465 PRO I 259 REMARK 465 GLU I 260 REMARK 465 VAL I 261 REMARK 465 THR I 262 REMARK 465 CYS I 263 REMARK 465 VAL I 264 REMARK 465 VAL I 265 REMARK 465 VAL I 266 REMARK 465 ASP I 267 REMARK 465 VAL I 268 REMARK 465 SER I 269 REMARK 465 HIS I 270 REMARK 465 GLU I 271 REMARK 465 ASP I 272 REMARK 465 PRO I 273 REMARK 465 GLU I 274 REMARK 465 VAL I 275 REMARK 465 LYS I 276 REMARK 465 PHE I 277 REMARK 465 ASN I 278 REMARK 465 TRP I 279 REMARK 465 TYR I 280 REMARK 465 VAL I 281 REMARK 465 ASP I 282 REMARK 465 GLY I 283 REMARK 465 VAL I 284 REMARK 465 GLU I 285 REMARK 465 VAL I 286 REMARK 465 HIS I 287 REMARK 465 ASN I 288 REMARK 465 ALA I 289 REMARK 465 LYS I 290 REMARK 465 THR I 291 REMARK 465 LYS I 292 REMARK 465 PRO I 293 REMARK 465 ARG I 294 REMARK 465 GLU I 295 REMARK 465 GLU I 296 REMARK 465 GLN I 297 REMARK 465 TYR I 298 REMARK 465 ASN I 299 REMARK 465 SER I 300 REMARK 465 THR I 301 REMARK 465 TYR I 302 REMARK 465 ARG I 303 REMARK 465 VAL I 304 REMARK 465 VAL I 305 REMARK 465 SER I 306 REMARK 465 VAL I 307 REMARK 465 LEU I 308 REMARK 465 THR I 309 REMARK 465 VAL I 310 REMARK 465 LEU I 311 REMARK 465 HIS I 312 REMARK 465 GLN I 313 REMARK 465 ASP I 314 REMARK 465 TRP I 315 REMARK 465 LEU I 316 REMARK 465 ASN I 317 REMARK 465 GLY I 318 REMARK 465 LYS I 319 REMARK 465 GLU I 320 REMARK 465 TYR I 321 REMARK 465 LYS I 322 REMARK 465 CYS I 323 REMARK 465 LYS I 324 REMARK 465 VAL I 325 REMARK 465 SER I 326 REMARK 465 ASN I 327 REMARK 465 LYS I 328 REMARK 465 ALA I 329 REMARK 465 LEU I 330 REMARK 465 PRO I 331 REMARK 465 ALA I 332 REMARK 465 PRO I 333 REMARK 465 ILE I 334 REMARK 465 GLU I 335 REMARK 465 LYS I 336 REMARK 465 THR I 337 REMARK 465 ILE I 338 REMARK 465 SER I 339 REMARK 465 LYS I 340 REMARK 465 ALA I 341 REMARK 465 LYS I 342 REMARK 465 GLY I 343 REMARK 465 GLN I 344 REMARK 465 PRO I 345 REMARK 465 ARG I 346 REMARK 465 GLU I 347 REMARK 465 PRO I 348 REMARK 465 GLN I 349 REMARK 465 VAL I 350 REMARK 465 TYR I 351 REMARK 465 THR I 352 REMARK 465 LEU I 353 REMARK 465 PRO I 354 REMARK 465 PRO I 355 REMARK 465 SER I 356 REMARK 465 ARG I 357 REMARK 465 GLU I 358 REMARK 465 GLU I 359 REMARK 465 MET I 360 REMARK 465 THR I 361 REMARK 465 LYS I 362 REMARK 465 ASN I 363 REMARK 465 GLN I 364 REMARK 465 VAL I 365 REMARK 465 SER I 366 REMARK 465 LEU I 367 REMARK 465 THR I 368 REMARK 465 CYS I 369 REMARK 465 LEU I 370 REMARK 465 VAL I 371 REMARK 465 LYS I 372 REMARK 465 GLY I 373 REMARK 465 PHE I 374 REMARK 465 TYR I 375 REMARK 465 PRO I 376 REMARK 465 SER I 377 REMARK 465 ASP I 378 REMARK 465 ILE I 379 REMARK 465 ALA I 380 REMARK 465 VAL I 381 REMARK 465 GLU I 382 REMARK 465 TRP I 383 REMARK 465 GLU I 384 REMARK 465 SER I 385 REMARK 465 ASN I 386 REMARK 465 GLY I 387 REMARK 465 GLN I 388 REMARK 465 PRO I 389 REMARK 465 GLU I 390 REMARK 465 ASN I 391 REMARK 465 ASN I 392 REMARK 465 TYR I 393 REMARK 465 LYS I 394 REMARK 465 THR I 395 REMARK 465 THR I 396 REMARK 465 PRO I 397 REMARK 465 PRO I 398 REMARK 465 VAL I 399 REMARK 465 LEU I 400 REMARK 465 ASP I 401 REMARK 465 SER I 402 REMARK 465 ASP I 403 REMARK 465 GLY I 404 REMARK 465 SER I 405 REMARK 465 PHE I 406 REMARK 465 PHE I 407 REMARK 465 LEU I 408 REMARK 465 TYR I 409 REMARK 465 SER I 410 REMARK 465 LYS I 411 REMARK 465 LEU I 412 REMARK 465 THR I 413 REMARK 465 VAL I 414 REMARK 465 ASP I 415 REMARK 465 LYS I 416 REMARK 465 SER I 417 REMARK 465 ARG I 418 REMARK 465 TRP I 419 REMARK 465 GLN I 420 REMARK 465 GLN I 421 REMARK 465 GLY I 422 REMARK 465 ASN I 423 REMARK 465 VAL I 424 REMARK 465 PHE I 425 REMARK 465 SER I 426 REMARK 465 CYS I 427 REMARK 465 SER I 428 REMARK 465 VAL I 429 REMARK 465 MET I 430 REMARK 465 HIS I 431 REMARK 465 GLU I 432 REMARK 465 ALA I 433 REMARK 465 LEU I 434 REMARK 465 HIS I 435 REMARK 465 ASN I 436 REMARK 465 HIS I 437 REMARK 465 TYR I 438 REMARK 465 THR I 439 REMARK 465 GLN I 440 REMARK 465 LYS I 441 REMARK 465 SER I 442 REMARK 465 LEU I 443 REMARK 465 SER I 444 REMARK 465 LEU I 445 REMARK 465 SER I 446 REMARK 465 PRO I 447 REMARK 465 GLY I 448 REMARK 465 LYS I 449 REMARK 465 THR M 108 REMARK 465 VAL M 109 REMARK 465 ALA M 110 REMARK 465 ALA M 111 REMARK 465 PRO M 112 REMARK 465 SER M 113 REMARK 465 VAL M 114 REMARK 465 PHE M 115 REMARK 465 ILE M 116 REMARK 465 PHE M 117 REMARK 465 PRO M 118 REMARK 465 PRO M 119 REMARK 465 SER M 120 REMARK 465 ASP M 121 REMARK 465 GLU M 122 REMARK 465 GLN M 123 REMARK 465 LEU M 124 REMARK 465 LYS M 125 REMARK 465 SER M 126 REMARK 465 GLY M 127 REMARK 465 THR M 128 REMARK 465 ALA M 129 REMARK 465 SER M 130 REMARK 465 VAL M 131 REMARK 465 VAL M 132 REMARK 465 CYS M 133 REMARK 465 LEU M 134 REMARK 465 LEU M 135 REMARK 465 ASN M 136 REMARK 465 ASN M 137 REMARK 465 PHE M 138 REMARK 465 TYR M 139 REMARK 465 PRO M 140 REMARK 465 ARG M 141 REMARK 465 GLU M 142 REMARK 465 ALA M 143 REMARK 465 LYS M 144 REMARK 465 VAL M 145 REMARK 465 GLN M 146 REMARK 465 TRP M 147 REMARK 465 LYS M 148 REMARK 465 VAL M 149 REMARK 465 ASP M 150 REMARK 465 ASN M 151 REMARK 465 ALA M 152 REMARK 465 LEU M 153 REMARK 465 GLN M 154 REMARK 465 SER M 155 REMARK 465 GLY M 156 REMARK 465 ASN M 157 REMARK 465 SER M 158 REMARK 465 GLN M 159 REMARK 465 GLU M 160 REMARK 465 SER M 161 REMARK 465 VAL M 162 REMARK 465 THR M 163 REMARK 465 GLU M 164 REMARK 465 GLN M 165 REMARK 465 ASP M 166 REMARK 465 SER M 167 REMARK 465 LYS M 168 REMARK 465 ASP M 169 REMARK 465 SER M 170 REMARK 465 THR M 171 REMARK 465 TYR M 172 REMARK 465 SER M 173 REMARK 465 LEU M 174 REMARK 465 SER M 175 REMARK 465 SER M 176 REMARK 465 THR M 177 REMARK 465 LEU M 178 REMARK 465 THR M 179 REMARK 465 LEU M 180 REMARK 465 SER M 181 REMARK 465 LYS M 182 REMARK 465 ALA M 183 REMARK 465 ASP M 184 REMARK 465 TYR M 185 REMARK 465 GLU M 186 REMARK 465 LYS M 187 REMARK 465 HIS M 188 REMARK 465 LYS M 189 REMARK 465 VAL M 190 REMARK 465 TYR M 191 REMARK 465 ALA M 192 REMARK 465 CYS M 193 REMARK 465 GLU M 194 REMARK 465 VAL M 195 REMARK 465 THR M 196 REMARK 465 HIS M 197 REMARK 465 GLN M 198 REMARK 465 GLY M 199 REMARK 465 LEU M 200 REMARK 465 SER M 201 REMARK 465 SER M 202 REMARK 465 PRO M 203 REMARK 465 VAL M 204 REMARK 465 THR M 205 REMARK 465 LYS M 206 REMARK 465 SER M 207 REMARK 465 PHE M 208 REMARK 465 ASN M 209 REMARK 465 ARG M 210 REMARK 465 GLY M 211 REMARK 465 GLU M 212 REMARK 465 CYS M 213 REMARK 465 THR J 122 REMARK 465 LYS J 123 REMARK 465 GLY J 124 REMARK 465 PRO J 125 REMARK 465 SER J 126 REMARK 465 VAL J 127 REMARK 465 PHE J 128 REMARK 465 PRO J 129 REMARK 465 LEU J 130 REMARK 465 ALA J 131 REMARK 465 PRO J 132 REMARK 465 SER J 133 REMARK 465 SER J 134 REMARK 465 LYS J 135 REMARK 465 SER J 136 REMARK 465 THR J 137 REMARK 465 SER J 138 REMARK 465 GLY J 139 REMARK 465 GLY J 140 REMARK 465 THR J 141 REMARK 465 ALA J 142 REMARK 465 ALA J 143 REMARK 465 LEU J 144 REMARK 465 GLY J 145 REMARK 465 CYS J 146 REMARK 465 LEU J 147 REMARK 465 VAL J 148 REMARK 465 LYS J 149 REMARK 465 ASP J 150 REMARK 465 TYR J 151 REMARK 465 PHE J 152 REMARK 465 PRO J 153 REMARK 465 GLU J 154 REMARK 465 PRO J 155 REMARK 465 VAL J 156 REMARK 465 THR J 157 REMARK 465 VAL J 158 REMARK 465 SER J 159 REMARK 465 TRP J 160 REMARK 465 ASN J 161 REMARK 465 SER J 162 REMARK 465 GLY J 163 REMARK 465 ALA J 164 REMARK 465 LEU J 165 REMARK 465 THR J 166 REMARK 465 SER J 167 REMARK 465 GLY J 168 REMARK 465 VAL J 169 REMARK 465 HIS J 170 REMARK 465 THR J 171 REMARK 465 PHE J 172 REMARK 465 PRO J 173 REMARK 465 ALA J 174 REMARK 465 VAL J 175 REMARK 465 LEU J 176 REMARK 465 GLN J 177 REMARK 465 SER J 178 REMARK 465 SER J 179 REMARK 465 GLY J 180 REMARK 465 LEU J 181 REMARK 465 TYR J 182 REMARK 465 SER J 183 REMARK 465 LEU J 184 REMARK 465 SER J 185 REMARK 465 SER J 186 REMARK 465 VAL J 187 REMARK 465 VAL J 188 REMARK 465 THR J 189 REMARK 465 VAL J 190 REMARK 465 PRO J 191 REMARK 465 SER J 192 REMARK 465 SER J 193 REMARK 465 SER J 194 REMARK 465 LEU J 195 REMARK 465 GLY J 196 REMARK 465 THR J 197 REMARK 465 GLN J 198 REMARK 465 THR J 199 REMARK 465 TYR J 200 REMARK 465 ILE J 201 REMARK 465 CYS J 202 REMARK 465 ASN J 203 REMARK 465 VAL J 204 REMARK 465 ASN J 205 REMARK 465 HIS J 206 REMARK 465 LYS J 207 REMARK 465 PRO J 208 REMARK 465 SER J 209 REMARK 465 ASN J 210 REMARK 465 THR J 211 REMARK 465 LYS J 212 REMARK 465 VAL J 213 REMARK 465 ASP J 214 REMARK 465 LYS J 215 REMARK 465 ARG J 216 REMARK 465 VAL J 217 REMARK 465 GLU J 218 REMARK 465 PRO J 219 REMARK 465 LYS J 220 REMARK 465 SER J 221 REMARK 465 CYS J 222 REMARK 465 ASP J 223 REMARK 465 LYS J 224 REMARK 465 THR J 225 REMARK 465 HIS J 226 REMARK 465 THR J 227 REMARK 465 CYS J 228 REMARK 465 PRO J 229 REMARK 465 PRO J 230 REMARK 465 CYS J 231 REMARK 465 PRO J 232 REMARK 465 ALA J 233 REMARK 465 PRO J 234 REMARK 465 GLU J 235 REMARK 465 LEU J 236 REMARK 465 LEU J 237 REMARK 465 GLY J 238 REMARK 465 GLY J 239 REMARK 465 PRO J 240 REMARK 465 SER J 241 REMARK 465 VAL J 242 REMARK 465 PHE J 243 REMARK 465 LEU J 244 REMARK 465 PHE J 245 REMARK 465 PRO J 246 REMARK 465 PRO J 247 REMARK 465 LYS J 248 REMARK 465 PRO J 249 REMARK 465 LYS J 250 REMARK 465 ASP J 251 REMARK 465 THR J 252 REMARK 465 LEU J 253 REMARK 465 MET J 254 REMARK 465 ILE J 255 REMARK 465 SER J 256 REMARK 465 ARG J 257 REMARK 465 THR J 258 REMARK 465 PRO J 259 REMARK 465 GLU J 260 REMARK 465 VAL J 261 REMARK 465 THR J 262 REMARK 465 CYS J 263 REMARK 465 VAL J 264 REMARK 465 VAL J 265 REMARK 465 VAL J 266 REMARK 465 ASP J 267 REMARK 465 VAL J 268 REMARK 465 SER J 269 REMARK 465 HIS J 270 REMARK 465 GLU J 271 REMARK 465 ASP J 272 REMARK 465 PRO J 273 REMARK 465 GLU J 274 REMARK 465 VAL J 275 REMARK 465 LYS J 276 REMARK 465 PHE J 277 REMARK 465 ASN J 278 REMARK 465 TRP J 279 REMARK 465 TYR J 280 REMARK 465 VAL J 281 REMARK 465 ASP J 282 REMARK 465 GLY J 283 REMARK 465 VAL J 284 REMARK 465 GLU J 285 REMARK 465 VAL J 286 REMARK 465 HIS J 287 REMARK 465 ASN J 288 REMARK 465 ALA J 289 REMARK 465 LYS J 290 REMARK 465 THR J 291 REMARK 465 LYS J 292 REMARK 465 PRO J 293 REMARK 465 ARG J 294 REMARK 465 GLU J 295 REMARK 465 GLU J 296 REMARK 465 GLN J 297 REMARK 465 TYR J 298 REMARK 465 ASN J 299 REMARK 465 SER J 300 REMARK 465 THR J 301 REMARK 465 TYR J 302 REMARK 465 ARG J 303 REMARK 465 VAL J 304 REMARK 465 VAL J 305 REMARK 465 SER J 306 REMARK 465 VAL J 307 REMARK 465 LEU J 308 REMARK 465 THR J 309 REMARK 465 VAL J 310 REMARK 465 LEU J 311 REMARK 465 HIS J 312 REMARK 465 GLN J 313 REMARK 465 ASP J 314 REMARK 465 TRP J 315 REMARK 465 LEU J 316 REMARK 465 ASN J 317 REMARK 465 GLY J 318 REMARK 465 LYS J 319 REMARK 465 GLU J 320 REMARK 465 TYR J 321 REMARK 465 LYS J 322 REMARK 465 CYS J 323 REMARK 465 LYS J 324 REMARK 465 VAL J 325 REMARK 465 SER J 326 REMARK 465 ASN J 327 REMARK 465 LYS J 328 REMARK 465 ALA J 329 REMARK 465 LEU J 330 REMARK 465 PRO J 331 REMARK 465 ALA J 332 REMARK 465 PRO J 333 REMARK 465 ILE J 334 REMARK 465 GLU J 335 REMARK 465 LYS J 336 REMARK 465 THR J 337 REMARK 465 ILE J 338 REMARK 465 SER J 339 REMARK 465 LYS J 340 REMARK 465 ALA J 341 REMARK 465 LYS J 342 REMARK 465 GLY J 343 REMARK 465 GLN J 344 REMARK 465 PRO J 345 REMARK 465 ARG J 346 REMARK 465 GLU J 347 REMARK 465 PRO J 348 REMARK 465 GLN J 349 REMARK 465 VAL J 350 REMARK 465 TYR J 351 REMARK 465 THR J 352 REMARK 465 LEU J 353 REMARK 465 PRO J 354 REMARK 465 PRO J 355 REMARK 465 SER J 356 REMARK 465 ARG J 357 REMARK 465 GLU J 358 REMARK 465 GLU J 359 REMARK 465 MET J 360 REMARK 465 THR J 361 REMARK 465 LYS J 362 REMARK 465 ASN J 363 REMARK 465 GLN J 364 REMARK 465 VAL J 365 REMARK 465 SER J 366 REMARK 465 LEU J 367 REMARK 465 THR J 368 REMARK 465 CYS J 369 REMARK 465 LEU J 370 REMARK 465 VAL J 371 REMARK 465 LYS J 372 REMARK 465 GLY J 373 REMARK 465 PHE J 374 REMARK 465 TYR J 375 REMARK 465 PRO J 376 REMARK 465 SER J 377 REMARK 465 ASP J 378 REMARK 465 ILE J 379 REMARK 465 ALA J 380 REMARK 465 VAL J 381 REMARK 465 GLU J 382 REMARK 465 TRP J 383 REMARK 465 GLU J 384 REMARK 465 SER J 385 REMARK 465 ASN J 386 REMARK 465 GLY J 387 REMARK 465 GLN J 388 REMARK 465 PRO J 389 REMARK 465 GLU J 390 REMARK 465 ASN J 391 REMARK 465 ASN J 392 REMARK 465 TYR J 393 REMARK 465 LYS J 394 REMARK 465 THR J 395 REMARK 465 THR J 396 REMARK 465 PRO J 397 REMARK 465 PRO J 398 REMARK 465 VAL J 399 REMARK 465 LEU J 400 REMARK 465 ASP J 401 REMARK 465 SER J 402 REMARK 465 ASP J 403 REMARK 465 GLY J 404 REMARK 465 SER J 405 REMARK 465 PHE J 406 REMARK 465 PHE J 407 REMARK 465 LEU J 408 REMARK 465 TYR J 409 REMARK 465 SER J 410 REMARK 465 LYS J 411 REMARK 465 LEU J 412 REMARK 465 THR J 413 REMARK 465 VAL J 414 REMARK 465 ASP J 415 REMARK 465 LYS J 416 REMARK 465 SER J 417 REMARK 465 ARG J 418 REMARK 465 TRP J 419 REMARK 465 GLN J 420 REMARK 465 GLN J 421 REMARK 465 GLY J 422 REMARK 465 ASN J 423 REMARK 465 VAL J 424 REMARK 465 PHE J 425 REMARK 465 SER J 426 REMARK 465 CYS J 427 REMARK 465 SER J 428 REMARK 465 VAL J 429 REMARK 465 MET J 430 REMARK 465 HIS J 431 REMARK 465 GLU J 432 REMARK 465 ALA J 433 REMARK 465 LEU J 434 REMARK 465 HIS J 435 REMARK 465 ASN J 436 REMARK 465 HIS J 437 REMARK 465 TYR J 438 REMARK 465 THR J 439 REMARK 465 GLN J 440 REMARK 465 LYS J 441 REMARK 465 SER J 442 REMARK 465 LEU J 443 REMARK 465 SER J 444 REMARK 465 LEU J 445 REMARK 465 SER J 446 REMARK 465 PRO J 447 REMARK 465 GLY J 448 REMARK 465 LYS J 449 REMARK 465 ARG N 107 REMARK 465 THR N 108 REMARK 465 VAL N 109 REMARK 465 ALA N 110 REMARK 465 ALA N 111 REMARK 465 PRO N 112 REMARK 465 SER N 113 REMARK 465 VAL N 114 REMARK 465 PHE N 115 REMARK 465 ILE N 116 REMARK 465 PHE N 117 REMARK 465 PRO N 118 REMARK 465 PRO N 119 REMARK 465 SER N 120 REMARK 465 ASP N 121 REMARK 465 GLU N 122 REMARK 465 GLN N 123 REMARK 465 LEU N 124 REMARK 465 LYS N 125 REMARK 465 SER N 126 REMARK 465 GLY N 127 REMARK 465 THR N 128 REMARK 465 ALA N 129 REMARK 465 SER N 130 REMARK 465 VAL N 131 REMARK 465 VAL N 132 REMARK 465 CYS N 133 REMARK 465 LEU N 134 REMARK 465 LEU N 135 REMARK 465 ASN N 136 REMARK 465 ASN N 137 REMARK 465 PHE N 138 REMARK 465 TYR N 139 REMARK 465 PRO N 140 REMARK 465 ARG N 141 REMARK 465 GLU N 142 REMARK 465 ALA N 143 REMARK 465 LYS N 144 REMARK 465 VAL N 145 REMARK 465 GLN N 146 REMARK 465 TRP N 147 REMARK 465 LYS N 148 REMARK 465 VAL N 149 REMARK 465 ASP N 150 REMARK 465 ASN N 151 REMARK 465 ALA N 152 REMARK 465 LEU N 153 REMARK 465 GLN N 154 REMARK 465 SER N 155 REMARK 465 GLY N 156 REMARK 465 ASN N 157 REMARK 465 SER N 158 REMARK 465 GLN N 159 REMARK 465 GLU N 160 REMARK 465 SER N 161 REMARK 465 VAL N 162 REMARK 465 THR N 163 REMARK 465 GLU N 164 REMARK 465 GLN N 165 REMARK 465 ASP N 166 REMARK 465 SER N 167 REMARK 465 LYS N 168 REMARK 465 ASP N 169 REMARK 465 SER N 170 REMARK 465 THR N 171 REMARK 465 TYR N 172 REMARK 465 SER N 173 REMARK 465 LEU N 174 REMARK 465 SER N 175 REMARK 465 SER N 176 REMARK 465 THR N 177 REMARK 465 LEU N 178 REMARK 465 THR N 179 REMARK 465 LEU N 180 REMARK 465 SER N 181 REMARK 465 LYS N 182 REMARK 465 ALA N 183 REMARK 465 ASP N 184 REMARK 465 TYR N 185 REMARK 465 GLU N 186 REMARK 465 LYS N 187 REMARK 465 HIS N 188 REMARK 465 LYS N 189 REMARK 465 VAL N 190 REMARK 465 TYR N 191 REMARK 465 ALA N 192 REMARK 465 CYS N 193 REMARK 465 GLU N 194 REMARK 465 VAL N 195 REMARK 465 THR N 196 REMARK 465 HIS N 197 REMARK 465 GLN N 198 REMARK 465 GLY N 199 REMARK 465 LEU N 200 REMARK 465 SER N 201 REMARK 465 SER N 202 REMARK 465 PRO N 203 REMARK 465 VAL N 204 REMARK 465 THR N 205 REMARK 465 LYS N 206 REMARK 465 SER N 207 REMARK 465 PHE N 208 REMARK 465 ASN N 209 REMARK 465 ARG N 210 REMARK 465 GLY N 211 REMARK 465 GLU N 212 REMARK 465 CYS N 213 REMARK 465 VAL A 498 REMARK 465 ASN A 499 REMARK 465 PHE A 500 REMARK 465 VAL A 501 REMARK 465 PHE A 547 REMARK 465 GLN A 548 REMARK 465 LEU A 549 REMARK 465 GLN A 550 REMARK 465 CYS A 551 REMARK 465 ASP A 552 REMARK 465 TRP A 553 REMARK 465 ASN A 554 REMARK 465 THR A 555 REMARK 465 SER A 556 REMARK 465 ASP A 557 REMARK 465 PHE A 558 REMARK 465 CYS A 559 REMARK 465 ILE A 560 REMARK 465 THR A 561 REMARK 465 PRO A 562 REMARK 465 GLN A 563 REMARK 465 ILE A 564 REMARK 465 TYR A 565 REMARK 465 ASN A 566 REMARK 465 GLU A 567 REMARK 465 SER A 568 REMARK 465 HIS A 604 REMARK 465 LEU A 605 REMARK 465 ASN A 606 REMARK 465 LEU A 607 REMARK 465 VAL A 608 REMARK 465 PRO A 609 REMARK 465 GLY A 610 REMARK 465 THR A 611 REMARK 465 GLU A 612 REMARK 465 ALA A 613 REMARK 465 ILE A 614 REMARK 465 ALA A 615 REMARK 465 GLY A 616 REMARK 465 VAL A 617 REMARK 465 ALA A 618 REMARK 465 ASP A 619 REMARK 465 GLY A 620 REMARK 465 LEU A 621 REMARK 465 ALA A 622 REMARK 465 ASN A 623 REMARK 465 LEU A 624 REMARK 465 ASN A 625 REMARK 465 PRO A 626 REMARK 465 VAL A 627 REMARK 465 THR A 628 REMARK 465 TRP A 629 REMARK 465 VAL A 630 REMARK 465 LYS A 631 REMARK 465 THR A 632 REMARK 465 VAL C 498 REMARK 465 ASN C 499 REMARK 465 PHE C 500 REMARK 465 VAL C 501 REMARK 465 LEU C 549 REMARK 465 GLN C 550 REMARK 465 CYS C 551 REMARK 465 ASP C 552 REMARK 465 TRP C 553 REMARK 465 ASN C 554 REMARK 465 THR C 555 REMARK 465 SER C 556 REMARK 465 ASP C 557 REMARK 465 PHE C 558 REMARK 465 CYS C 559 REMARK 465 ILE C 560 REMARK 465 THR C 561 REMARK 465 PRO C 562 REMARK 465 GLN C 563 REMARK 465 ILE C 564 REMARK 465 TYR C 565 REMARK 465 ASN C 566 REMARK 465 HIS C 604 REMARK 465 LEU C 605 REMARK 465 ASN C 606 REMARK 465 LEU C 607 REMARK 465 VAL C 608 REMARK 465 PRO C 609 REMARK 465 GLY C 610 REMARK 465 THR C 611 REMARK 465 GLU C 612 REMARK 465 ALA C 613 REMARK 465 ILE C 614 REMARK 465 ALA C 615 REMARK 465 GLY C 616 REMARK 465 VAL C 617 REMARK 465 ALA C 618 REMARK 465 ASP C 619 REMARK 465 GLY C 620 REMARK 465 LEU C 621 REMARK 465 ALA C 622 REMARK 465 ASN C 623 REMARK 465 LEU C 624 REMARK 465 ASN C 625 REMARK 465 PRO C 626 REMARK 465 VAL C 627 REMARK 465 THR C 628 REMARK 465 TRP C 629 REMARK 465 VAL C 630 REMARK 465 LYS C 631 REMARK 465 THR C 632 REMARK 465 VAL B 498 REMARK 465 ASN B 499 REMARK 465 PHE B 500 REMARK 465 VAL B 501 REMARK 465 LEU B 549 REMARK 465 GLN B 550 REMARK 465 CYS B 551 REMARK 465 ASP B 552 REMARK 465 TRP B 553 REMARK 465 ASN B 554 REMARK 465 THR B 555 REMARK 465 SER B 556 REMARK 465 ASP B 557 REMARK 465 PHE B 558 REMARK 465 CYS B 559 REMARK 465 ILE B 560 REMARK 465 THR B 561 REMARK 465 PRO B 562 REMARK 465 GLN B 563 REMARK 465 ILE B 564 REMARK 465 TYR B 565 REMARK 465 ASN B 566 REMARK 465 HIS B 604 REMARK 465 LEU B 605 REMARK 465 ASN B 606 REMARK 465 LEU B 607 REMARK 465 VAL B 608 REMARK 465 PRO B 609 REMARK 465 GLY B 610 REMARK 465 THR B 611 REMARK 465 GLU B 612 REMARK 465 ALA B 613 REMARK 465 ILE B 614 REMARK 465 ALA B 615 REMARK 465 GLY B 616 REMARK 465 VAL B 617 REMARK 465 ALA B 618 REMARK 465 ASP B 619 REMARK 465 GLY B 620 REMARK 465 LEU B 621 REMARK 465 ALA B 622 REMARK 465 ASN B 623 REMARK 465 LEU B 624 REMARK 465 ASN B 625 REMARK 465 PRO B 626 REMARK 465 VAL B 627 REMARK 465 THR B 628 REMARK 465 TRP B 629 REMARK 465 VAL B 630 REMARK 465 LYS B 631 REMARK 465 THR B 632 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 TRP A 504 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP A 504 CZ3 CH2 REMARK 470 TRP C 504 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP C 504 CZ3 CH2 REMARK 470 TRP B 504 CG CD1 CD2 NE1 CE2 CE3 CZ2 REMARK 470 TRP B 504 CZ3 CH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 TYR H 33 161.56 68.10 REMARK 500 THR L 50 7.59 53.68 REMARK 500 TYR I 33 165.39 66.58 REMARK 500 ASN I 44 37.38 70.00 REMARK 500 THR I 88 -9.50 -57.21 REMARK 500 SER I 118 149.01 -171.68 REMARK 500 THR M 50 7.09 53.92 REMARK 500 SER M 51 -37.08 -131.32 REMARK 500 TYR J 33 164.36 68.11 REMARK 500 THR N 50 -3.57 59.88 REMARK 500 HIS A 570 166.01 64.91 REMARK 500 HIS A 571 -8.67 71.22 REMARK 500 ASN A 585 -99.26 60.77 REMARK 500 LEU A 586 -3.34 69.13 REMARK 500 HIS C 571 -6.81 72.04 REMARK 500 ASN C 585 -100.89 62.31 REMARK 500 LEU B 588 -7.00 67.25 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-48374 RELATED DB: EMDB REMARK 900 POST-FUSION HERV-K ENVELOPE PROTEIN IN COMPLEX WITH KENV-4 FAB DBREF 9MLK H 1 449 PDB 9MLK 9MLK 1 449 DBREF 9MLK L 1 213 PDB 9MLK 9MLK 1 213 DBREF 9MLK I 1 449 PDB 9MLK 9MLK 1 449 DBREF 9MLK M 1 213 PDB 9MLK 9MLK 1 213 DBREF 9MLK J 1 449 PDB 9MLK 9MLK 1 449 DBREF 9MLK N 1 213 PDB 9MLK 9MLK 1 213 DBREF 9MLK A 498 632 UNP Q69384 ENK6_HUMAN 498 632 DBREF 9MLK C 498 632 UNP Q69384 ENK6_HUMAN 498 632 DBREF 9MLK B 498 632 UNP Q69384 ENK6_HUMAN 498 632 SEQRES 1 H 449 ASP VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 H 449 PRO SER GLN SER LEU SER LEU THR CYS THR VAL THR GLY SEQRES 3 H 449 TYR SER ILE THR SER ASP TYR ALA TRP ASN TRP ILE ARG SEQRES 4 H 449 GLN PHE PRO GLY ASN GLU LEU GLU TRP MET GLY TYR ILE SEQRES 5 H 449 SER TYR SER GLY SER THR SER TYR ASN PRO SER LEU LYS SEQRES 6 H 449 SER ARG ILE SER ILE THR ARG ASP THR SER LYS ASN GLN SEQRES 7 H 449 PHE PHE LEU GLN LEU ASN PRO VAL THR THR GLU ASP THR SEQRES 8 H 449 ALA THR TYR TYR CYS ALA ARG SER VAL ILE LEU GLY ALA SEQRES 9 H 449 TRP PHE ALA TYR TRP GLY GLN GLY THR LEU VAL THR VAL SEQRES 10 H 449 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 H 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 H 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 H 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 H 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 H 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 H 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 H 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 H 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 H 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 H 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 H 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 H 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 H 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 H 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 H 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 H 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 H 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 H 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 H 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 H 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 H 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 H 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 H 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 H 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 H 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 L 213 ASP ILE LYS MET THR GLN SER PRO SER LEU MET SER ALA SEQRES 2 L 213 SER PRO GLY GLU LYS VAL THR MET THR CYS SER ALA SER SEQRES 3 L 213 SER SER ILE THR TYR MET TYR TRP TYR GLN GLN LYS PRO SEQRES 4 L 213 ARG SER SER PRO LYS PRO TRP ILE TYR LEU THR SER ASN SEQRES 5 L 213 LEU ALA SER GLY VAL PRO ALA ARG PHE SER GLY SER GLY SEQRES 6 L 213 SER GLY THR SER TYR SER LEU THR ILE SER SER MET GLU SEQRES 7 L 213 ALA GLU ASP ALA ALA THR TYR TYR CYS GLN GLN TRP SER SEQRES 8 L 213 SER ASN PRO LEU THR PHE GLY ALA GLY THR LYS LEU GLU SEQRES 9 L 213 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 L 213 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 L 213 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 L 213 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 L 213 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 L 213 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 L 213 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 L 213 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 L 213 ASN ARG GLY GLU CYS SEQRES 1 I 449 ASP VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 I 449 PRO SER GLN SER LEU SER LEU THR CYS THR VAL THR GLY SEQRES 3 I 449 TYR SER ILE THR SER ASP TYR ALA TRP ASN TRP ILE ARG SEQRES 4 I 449 GLN PHE PRO GLY ASN GLU LEU GLU TRP MET GLY TYR ILE SEQRES 5 I 449 SER TYR SER GLY SER THR SER TYR ASN PRO SER LEU LYS SEQRES 6 I 449 SER ARG ILE SER ILE THR ARG ASP THR SER LYS ASN GLN SEQRES 7 I 449 PHE PHE LEU GLN LEU ASN PRO VAL THR THR GLU ASP THR SEQRES 8 I 449 ALA THR TYR TYR CYS ALA ARG SER VAL ILE LEU GLY ALA SEQRES 9 I 449 TRP PHE ALA TYR TRP GLY GLN GLY THR LEU VAL THR VAL SEQRES 10 I 449 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 I 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 I 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 I 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 I 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 I 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 I 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 I 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 I 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 I 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 I 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 I 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 I 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 I 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 I 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 I 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 I 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 I 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 I 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 I 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 I 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 I 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 I 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 I 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 I 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 I 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 M 213 ASP ILE LYS MET THR GLN SER PRO SER LEU MET SER ALA SEQRES 2 M 213 SER PRO GLY GLU LYS VAL THR MET THR CYS SER ALA SER SEQRES 3 M 213 SER SER ILE THR TYR MET TYR TRP TYR GLN GLN LYS PRO SEQRES 4 M 213 ARG SER SER PRO LYS PRO TRP ILE TYR LEU THR SER ASN SEQRES 5 M 213 LEU ALA SER GLY VAL PRO ALA ARG PHE SER GLY SER GLY SEQRES 6 M 213 SER GLY THR SER TYR SER LEU THR ILE SER SER MET GLU SEQRES 7 M 213 ALA GLU ASP ALA ALA THR TYR TYR CYS GLN GLN TRP SER SEQRES 8 M 213 SER ASN PRO LEU THR PHE GLY ALA GLY THR LYS LEU GLU SEQRES 9 M 213 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 M 213 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 M 213 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 M 213 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 M 213 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 M 213 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 M 213 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 M 213 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 M 213 ASN ARG GLY GLU CYS SEQRES 1 J 449 ASP VAL GLN LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 J 449 PRO SER GLN SER LEU SER LEU THR CYS THR VAL THR GLY SEQRES 3 J 449 TYR SER ILE THR SER ASP TYR ALA TRP ASN TRP ILE ARG SEQRES 4 J 449 GLN PHE PRO GLY ASN GLU LEU GLU TRP MET GLY TYR ILE SEQRES 5 J 449 SER TYR SER GLY SER THR SER TYR ASN PRO SER LEU LYS SEQRES 6 J 449 SER ARG ILE SER ILE THR ARG ASP THR SER LYS ASN GLN SEQRES 7 J 449 PHE PHE LEU GLN LEU ASN PRO VAL THR THR GLU ASP THR SEQRES 8 J 449 ALA THR TYR TYR CYS ALA ARG SER VAL ILE LEU GLY ALA SEQRES 9 J 449 TRP PHE ALA TYR TRP GLY GLN GLY THR LEU VAL THR VAL SEQRES 10 J 449 SER ALA ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 11 J 449 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 12 J 449 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 13 J 449 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 14 J 449 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 15 J 449 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 16 J 449 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 17 J 449 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 18 J 449 CYS ASP LYS THR HIS THR CYS PRO PRO CYS PRO ALA PRO SEQRES 19 J 449 GLU LEU LEU GLY GLY PRO SER VAL PHE LEU PHE PRO PRO SEQRES 20 J 449 LYS PRO LYS ASP THR LEU MET ILE SER ARG THR PRO GLU SEQRES 21 J 449 VAL THR CYS VAL VAL VAL ASP VAL SER HIS GLU ASP PRO SEQRES 22 J 449 GLU VAL LYS PHE ASN TRP TYR VAL ASP GLY VAL GLU VAL SEQRES 23 J 449 HIS ASN ALA LYS THR LYS PRO ARG GLU GLU GLN TYR ASN SEQRES 24 J 449 SER THR TYR ARG VAL VAL SER VAL LEU THR VAL LEU HIS SEQRES 25 J 449 GLN ASP TRP LEU ASN GLY LYS GLU TYR LYS CYS LYS VAL SEQRES 26 J 449 SER ASN LYS ALA LEU PRO ALA PRO ILE GLU LYS THR ILE SEQRES 27 J 449 SER LYS ALA LYS GLY GLN PRO ARG GLU PRO GLN VAL TYR SEQRES 28 J 449 THR LEU PRO PRO SER ARG GLU GLU MET THR LYS ASN GLN SEQRES 29 J 449 VAL SER LEU THR CYS LEU VAL LYS GLY PHE TYR PRO SER SEQRES 30 J 449 ASP ILE ALA VAL GLU TRP GLU SER ASN GLY GLN PRO GLU SEQRES 31 J 449 ASN ASN TYR LYS THR THR PRO PRO VAL LEU ASP SER ASP SEQRES 32 J 449 GLY SER PHE PHE LEU TYR SER LYS LEU THR VAL ASP LYS SEQRES 33 J 449 SER ARG TRP GLN GLN GLY ASN VAL PHE SER CYS SER VAL SEQRES 34 J 449 MET HIS GLU ALA LEU HIS ASN HIS TYR THR GLN LYS SER SEQRES 35 J 449 LEU SER LEU SER PRO GLY LYS SEQRES 1 N 213 ASP ILE LYS MET THR GLN SER PRO SER LEU MET SER ALA SEQRES 2 N 213 SER PRO GLY GLU LYS VAL THR MET THR CYS SER ALA SER SEQRES 3 N 213 SER SER ILE THR TYR MET TYR TRP TYR GLN GLN LYS PRO SEQRES 4 N 213 ARG SER SER PRO LYS PRO TRP ILE TYR LEU THR SER ASN SEQRES 5 N 213 LEU ALA SER GLY VAL PRO ALA ARG PHE SER GLY SER GLY SEQRES 6 N 213 SER GLY THR SER TYR SER LEU THR ILE SER SER MET GLU SEQRES 7 N 213 ALA GLU ASP ALA ALA THR TYR TYR CYS GLN GLN TRP SER SEQRES 8 N 213 SER ASN PRO LEU THR PHE GLY ALA GLY THR LYS LEU GLU SEQRES 9 N 213 ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE PHE SEQRES 10 N 213 PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SER SEQRES 11 N 213 VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU ALA SEQRES 12 N 213 LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER GLY SEQRES 13 N 213 ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS ASP SEQRES 14 N 213 SER THR TYR SER LEU SER SER THR LEU THR LEU SER LYS SEQRES 15 N 213 ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL SEQRES 16 N 213 THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER PHE SEQRES 17 N 213 ASN ARG GLY GLU CYS SEQRES 1 A 135 VAL ASN PHE VAL ASN ASP TRP GLN LYS ASN SER THR ARG SEQRES 2 A 135 LEU TRP ASN SER GLN SER SER ILE ASP GLN LYS LEU ALA SEQRES 3 A 135 ASN GLN ILE ASN ASP LEU ARG GLN THR VAL ILE TRP MET SEQRES 4 A 135 GLY ASP ARG LEU MET SER LEU GLU HIS ARG PHE GLN LEU SEQRES 5 A 135 GLN CYS ASP TRP ASN THR SER ASP PHE CYS ILE THR PRO SEQRES 6 A 135 GLN ILE TYR ASN GLU SER GLU HIS HIS TRP ASP MET VAL SEQRES 7 A 135 ARG ARG HIS LEU GLN GLY ARG GLU ASP ASN LEU THR LEU SEQRES 8 A 135 ASP ILE SER LYS LEU LYS GLU GLN ILE PHE GLU ALA SER SEQRES 9 A 135 LYS ALA HIS LEU ASN LEU VAL PRO GLY THR GLU ALA ILE SEQRES 10 A 135 ALA GLY VAL ALA ASP GLY LEU ALA ASN LEU ASN PRO VAL SEQRES 11 A 135 THR TRP VAL LYS THR SEQRES 1 C 135 VAL ASN PHE VAL ASN ASP TRP GLN LYS ASN SER THR ARG SEQRES 2 C 135 LEU TRP ASN SER GLN SER SER ILE ASP GLN LYS LEU ALA SEQRES 3 C 135 ASN GLN ILE ASN ASP LEU ARG GLN THR VAL ILE TRP MET SEQRES 4 C 135 GLY ASP ARG LEU MET SER LEU GLU HIS ARG PHE GLN LEU SEQRES 5 C 135 GLN CYS ASP TRP ASN THR SER ASP PHE CYS ILE THR PRO SEQRES 6 C 135 GLN ILE TYR ASN GLU SER GLU HIS HIS TRP ASP MET VAL SEQRES 7 C 135 ARG ARG HIS LEU GLN GLY ARG GLU ASP ASN LEU THR LEU SEQRES 8 C 135 ASP ILE SER LYS LEU LYS GLU GLN ILE PHE GLU ALA SER SEQRES 9 C 135 LYS ALA HIS LEU ASN LEU VAL PRO GLY THR GLU ALA ILE SEQRES 10 C 135 ALA GLY VAL ALA ASP GLY LEU ALA ASN LEU ASN PRO VAL SEQRES 11 C 135 THR TRP VAL LYS THR SEQRES 1 B 135 VAL ASN PHE VAL ASN ASP TRP GLN LYS ASN SER THR ARG SEQRES 2 B 135 LEU TRP ASN SER GLN SER SER ILE ASP GLN LYS LEU ALA SEQRES 3 B 135 ASN GLN ILE ASN ASP LEU ARG GLN THR VAL ILE TRP MET SEQRES 4 B 135 GLY ASP ARG LEU MET SER LEU GLU HIS ARG PHE GLN LEU SEQRES 5 B 135 GLN CYS ASP TRP ASN THR SER ASP PHE CYS ILE THR PRO SEQRES 6 B 135 GLN ILE TYR ASN GLU SER GLU HIS HIS TRP ASP MET VAL SEQRES 7 B 135 ARG ARG HIS LEU GLN GLY ARG GLU ASP ASN LEU THR LEU SEQRES 8 B 135 ASP ILE SER LYS LEU LYS GLU GLN ILE PHE GLU ALA SER SEQRES 9 B 135 LYS ALA HIS LEU ASN LEU VAL PRO GLY THR GLU ALA ILE SEQRES 10 B 135 ALA GLY VAL ALA ASP GLY LEU ALA ASN LEU ASN PRO VAL SEQRES 11 B 135 THR TRP VAL LYS THR HELIX 1 AA1 THR H 87 THR H 91 5 5 HELIX 2 AA2 GLU L 78 ALA L 82 5 5 HELIX 3 AA3 PRO I 62 LYS I 65 5 4 HELIX 4 AA4 THR I 87 THR I 91 5 5 HELIX 5 AA5 GLU M 78 ALA M 82 5 5 HELIX 6 AA6 LEU J 64 SER J 66 5 3 HELIX 7 AA7 THR J 87 THR J 91 5 5 HELIX 8 AA8 GLU N 78 ALA N 82 5 5 HELIX 9 AA9 ASP A 503 ARG A 546 1 44 HELIX 10 AB1 HIS A 571 GLN A 580 1 10 HELIX 11 AB2 THR A 587 ALA A 603 1 17 HELIX 12 AB3 ASP C 503 PHE C 547 1 45 HELIX 13 AB4 TRP C 572 GLY C 581 1 10 HELIX 14 AB5 THR C 587 LYS C 602 1 16 HELIX 15 AB6 ASP B 503 GLN B 548 1 46 HELIX 16 AB7 SER B 568 GLY B 581 1 14 HELIX 17 AB8 ASP B 589 LYS B 602 1 14 SHEET 1 AA1 4 GLN H 3 SER H 7 0 SHEET 2 AA1 4 LEU H 18 THR H 25 -1 O THR H 21 N SER H 7 SHEET 3 AA1 4 GLN H 78 LEU H 83 -1 O LEU H 83 N LEU H 18 SHEET 4 AA1 4 ILE H 68 ASP H 73 -1 N ASP H 73 O GLN H 78 SHEET 1 AA2 6 LEU H 11 VAL H 12 0 SHEET 2 AA2 6 THR H 113 VAL H 117 1 O THR H 116 N VAL H 12 SHEET 3 AA2 6 ALA H 92 SER H 99 -1 N ALA H 92 O VAL H 115 SHEET 4 AA2 6 ALA H 34 GLN H 40 -1 N ILE H 38 O TYR H 95 SHEET 5 AA2 6 LEU H 46 ILE H 52 -1 O GLU H 47 N ARG H 39 SHEET 6 AA2 6 THR H 58 TYR H 60 -1 O SER H 59 N TYR H 51 SHEET 1 AA3 4 LEU H 11 VAL H 12 0 SHEET 2 AA3 4 THR H 113 VAL H 117 1 O THR H 116 N VAL H 12 SHEET 3 AA3 4 ALA H 92 SER H 99 -1 N ALA H 92 O VAL H 115 SHEET 4 AA3 4 PHE H 106 TRP H 109 -1 O TYR H 108 N ARG H 98 SHEET 1 AA4 4 MET L 4 GLN L 6 0 SHEET 2 AA4 4 VAL L 19 ALA L 25 -1 O SER L 24 N THR L 5 SHEET 3 AA4 4 SER L 69 ILE L 74 -1 O ILE L 74 N VAL L 19 SHEET 4 AA4 4 PHE L 61 SER L 66 -1 N SER L 64 O SER L 71 SHEET 1 AA5 5 ASN L 52 LEU L 53 0 SHEET 2 AA5 5 LYS L 44 TYR L 48 -1 N TYR L 48 O ASN L 52 SHEET 3 AA5 5 TYR L 31 GLN L 37 -1 N GLN L 36 O LYS L 44 SHEET 4 AA5 5 THR L 84 TRP L 90 -1 O THR L 84 N GLN L 37 SHEET 5 AA5 5 THR L 96 PHE L 97 -1 O THR L 96 N GLN L 89 SHEET 1 AA6 4 GLN I 3 SER I 7 0 SHEET 2 AA6 4 LEU I 18 THR I 25 -1 O THR I 23 N GLN I 5 SHEET 3 AA6 4 GLN I 78 LEU I 83 -1 O LEU I 81 N LEU I 20 SHEET 4 AA6 4 ILE I 68 ASP I 73 -1 N THR I 71 O PHE I 80 SHEET 1 AA7 6 LEU I 11 VAL I 12 0 SHEET 2 AA7 6 THR I 113 VAL I 117 1 O THR I 116 N VAL I 12 SHEET 3 AA7 6 ALA I 92 SER I 99 -1 N ALA I 92 O VAL I 115 SHEET 4 AA7 6 ALA I 34 GLN I 40 -1 N ILE I 38 O TYR I 95 SHEET 5 AA7 6 LEU I 46 ILE I 52 -1 O MET I 49 N TRP I 37 SHEET 6 AA7 6 THR I 58 TYR I 60 -1 O SER I 59 N TYR I 51 SHEET 1 AA8 4 LEU I 11 VAL I 12 0 SHEET 2 AA8 4 THR I 113 VAL I 117 1 O THR I 116 N VAL I 12 SHEET 3 AA8 4 ALA I 92 SER I 99 -1 N ALA I 92 O VAL I 115 SHEET 4 AA8 4 PHE I 106 TRP I 109 -1 O ALA I 107 N ARG I 98 SHEET 1 AA9 4 MET M 4 SER M 7 0 SHEET 2 AA9 4 VAL M 19 ALA M 25 -1 O THR M 22 N SER M 7 SHEET 3 AA9 4 SER M 69 ILE M 74 -1 O TYR M 70 N CYS M 23 SHEET 4 AA9 4 PHE M 61 SER M 66 -1 N SER M 62 O THR M 73 SHEET 1 AB1 5 ASN M 52 LEU M 53 0 SHEET 2 AB1 5 LYS M 44 TYR M 48 -1 N TYR M 48 O ASN M 52 SHEET 3 AB1 5 TYR M 31 GLN M 37 -1 N GLN M 36 O LYS M 44 SHEET 4 AB1 5 THR M 84 TRP M 90 -1 O THR M 84 N GLN M 37 SHEET 5 AB1 5 THR M 96 PHE M 97 -1 O THR M 96 N GLN M 89 SHEET 1 AB2 5 ASN M 52 LEU M 53 0 SHEET 2 AB2 5 LYS M 44 TYR M 48 -1 N TYR M 48 O ASN M 52 SHEET 3 AB2 5 TYR M 31 GLN M 37 -1 N GLN M 36 O LYS M 44 SHEET 4 AB2 5 THR M 84 TRP M 90 -1 O THR M 84 N GLN M 37 SHEET 5 AB2 5 THR M 101 LYS M 102 -1 O THR M 101 N TYR M 85 SHEET 1 AB3 4 GLN J 3 SER J 7 0 SHEET 2 AB3 4 LEU J 18 THR J 25 -1 O THR J 23 N GLN J 5 SHEET 3 AB3 4 GLN J 78 LEU J 83 -1 O LEU J 83 N LEU J 18 SHEET 4 AB3 4 ILE J 68 ASP J 73 -1 N ASP J 73 O GLN J 78 SHEET 1 AB4 6 LEU J 11 VAL J 12 0 SHEET 2 AB4 6 THR J 113 VAL J 117 1 O THR J 116 N VAL J 12 SHEET 3 AB4 6 ALA J 92 SER J 99 -1 N ALA J 92 O VAL J 115 SHEET 4 AB4 6 ALA J 34 GLN J 40 -1 N ILE J 38 O TYR J 95 SHEET 5 AB4 6 LEU J 46 ILE J 52 -1 O MET J 49 N TRP J 37 SHEET 6 AB4 6 THR J 58 TYR J 60 -1 O SER J 59 N TYR J 51 SHEET 1 AB5 4 LEU J 11 VAL J 12 0 SHEET 2 AB5 4 THR J 113 VAL J 117 1 O THR J 116 N VAL J 12 SHEET 3 AB5 4 ALA J 92 SER J 99 -1 N ALA J 92 O VAL J 115 SHEET 4 AB5 4 PHE J 106 TRP J 109 -1 O TYR J 108 N ARG J 98 SHEET 1 AB6 4 MET N 4 SER N 7 0 SHEET 2 AB6 4 VAL N 19 ALA N 25 -1 O SER N 24 N THR N 5 SHEET 3 AB6 4 SER N 69 ILE N 74 -1 O LEU N 72 N MET N 21 SHEET 4 AB6 4 PHE N 61 SER N 66 -1 N SER N 64 O SER N 71 SHEET 1 AB7 5 ASN N 52 LEU N 53 0 SHEET 2 AB7 5 LYS N 44 TYR N 48 -1 N TYR N 48 O ASN N 52 SHEET 3 AB7 5 TYR N 31 GLN N 37 -1 N GLN N 36 O LYS N 44 SHEET 4 AB7 5 THR N 84 TRP N 90 -1 O TYR N 86 N TYR N 35 SHEET 5 AB7 5 THR N 96 PHE N 97 -1 O THR N 96 N GLN N 89 SHEET 1 AB8 5 ASN N 52 LEU N 53 0 SHEET 2 AB8 5 LYS N 44 TYR N 48 -1 N TYR N 48 O ASN N 52 SHEET 3 AB8 5 TYR N 31 GLN N 37 -1 N GLN N 36 O LYS N 44 SHEET 4 AB8 5 THR N 84 TRP N 90 -1 O TYR N 86 N TYR N 35 SHEET 5 AB8 5 THR N 101 LYS N 102 -1 O THR N 101 N TYR N 85 SSBOND 1 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 2 CYS L 23 CYS L 87 1555 1555 2.03 SSBOND 3 CYS I 22 CYS I 96 1555 1555 2.03 SSBOND 4 CYS M 23 CYS M 87 1555 1555 2.03 SSBOND 5 CYS J 22 CYS J 96 1555 1555 2.03 SSBOND 6 CYS N 23 CYS N 87 1555 1555 2.03 CISPEP 1 ASN L 93 PRO L 94 0 1.30 CISPEP 2 SER M 7 PRO M 8 0 -5.57 CISPEP 3 ASN M 93 PRO M 94 0 0.11 CISPEP 4 SER N 7 PRO N 8 0 -9.19 CISPEP 5 ASN N 93 PRO N 94 0 -1.50 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000