HEADER ANTIVIRAL PROTEIN 16-JAN-25 9MVU TITLE C6 HERPES VIRUS SIMPLEX NEUTRALIZING NANOBODY BOUND TO HSV TITLE 2 GLYCOPROTEIN GB COMPND MOL_ID: 1; COMPND 2 MOLECULE: ENVELOPE GLYCOPROTEIN B; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: GB; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: C6 NEUTRALIZING NANOBODY; COMPND 8 CHAIN: D, E, F; COMPND 9 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN HERPESVIRUS 1 (STRAIN 17); SOURCE 3 ORGANISM_COMMON: HHV-1, HUMAN HERPES SIMPLEX VIRUS 1; SOURCE 4 ORGANISM_TAXID: 10299; SOURCE 5 STRAIN: 17; SOURCE 6 GENE: GB, UL27; SOURCE 7 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 8 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 9 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 10 MOL_ID: 2; SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 12 ORGANISM_COMMON: HUMAN; SOURCE 13 ORGANISM_TAXID: 9606; SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 15 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 17 EXPRESSION_SYSTEM_CELL_LINE: HEK293 KEYWDS NEUTRALIZING ANTIBODY, ANTIVIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR H.VIADIU,E.ABERNATHY,C.V.LEE,M.HUNG,Y.YU,W.XING,X.YU REVDAT 1 13-AUG-25 9MVU 0 JRNL AUTH C.V.LEE,H.VIADIU,A.KALAMKAR,D.I.BERNSTEIN,A.PAE,X.YU,S.WONG, JRNL AUTH 2 F.J.BRAVO,S.DING,E.SETO,M.HUNG,Y.YU,W.XING,G.A.PAPALIA, JRNL AUTH 3 W.KAN,B.CARR,M.THOMAS,L.TONG,P.DESAI,N.JARROUSSE,A.MERCIER, JRNL AUTH 4 M.M.HOLDORF,S.P.FLETCHER,E.ABERNATHY JRNL TITL IDENTIFICATION AND ENGINEERING OF POTENT BISPECIFIC JRNL TITL 2 ANTIBODIES THAT PROTECT AGAINST HERPES SIMPLEX VIRUS JRNL TITL 3 RECURRENT DISEASE. JRNL REF CELL REP V. 44 16063 2025 JRNL REFN ESSN 2211-1247 JRNL PMID 40716063 JRNL DOI 10.1016/J.CELREP.2025.116063 REMARK 2 REMARK 2 RESOLUTION. 2.20 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX, EPU, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : FOURIER SPACE REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.200 REMARK 3 NUMBER OF PARTICLES : 149170 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9MVU COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 16-JAN-25. REMARK 100 THE DEPOSITION ID IS D_1000291860. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : ONE C6 NEUTRALIZING NANOBODY REMARK 245 BOUND TO EACH MONOMER OF THE REMARK 245 HSV GLYCOPROTEIN B TRIMER REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 2.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : THERE ARE 6 MOLECULES IN THE REMARK 245 COMPLEX. A TRIMER OF HSV GLYCOPROTEIN B AND ONE C6 NEUTRALIZING REMARK 245 NANOBODY BOUND TO EACH GLYCOPROTEIN B MONOMER. REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : TFS FALCON 4I (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 600.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5200.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 165000 REMARK 245 CALIBRATED MAGNIFICATION : 165000 REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA A 28 REMARK 465 PRO A 29 REMARK 465 ALA A 30 REMARK 465 ALA A 31 REMARK 465 PRO A 32 REMARK 465 ALA A 33 REMARK 465 ALA A 34 REMARK 465 PRO A 35 REMARK 465 ARG A 36 REMARK 465 ALA A 37 REMARK 465 SER A 38 REMARK 465 GLY A 39 REMARK 465 GLY A 40 REMARK 465 VAL A 41 REMARK 465 ALA A 42 REMARK 465 ALA A 43 REMARK 465 THR A 44 REMARK 465 VAL A 45 REMARK 465 ALA A 46 REMARK 465 ALA A 47 REMARK 465 ASN A 48 REMARK 465 GLY A 49 REMARK 465 GLY A 50 REMARK 465 PRO A 51 REMARK 465 ALA A 52 REMARK 465 SER A 53 REMARK 465 ARG A 54 REMARK 465 PRO A 55 REMARK 465 PRO A 56 REMARK 465 PRO A 57 REMARK 465 VAL A 58 REMARK 465 PRO A 59 REMARK 465 SER A 60 REMARK 465 PRO A 61 REMARK 465 ALA A 62 REMARK 465 THR A 63 REMARK 465 THR A 64 REMARK 465 LYS A 65 REMARK 465 ALA A 66 REMARK 465 ARG A 67 REMARK 465 LYS A 68 REMARK 465 ARG A 69 REMARK 465 LYS A 70 REMARK 465 THR A 71 REMARK 465 LYS A 72 REMARK 465 LYS A 73 REMARK 465 PRO A 74 REMARK 465 PRO A 75 REMARK 465 LYS A 76 REMARK 465 ARG A 77 REMARK 465 PRO A 78 REMARK 465 GLU A 79 REMARK 465 ALA A 80 REMARK 465 THR A 81 REMARK 465 PRO A 82 REMARK 465 PRO A 83 REMARK 465 PRO A 84 REMARK 465 ASP A 85 REMARK 465 ALA A 86 REMARK 465 ASN A 87 REMARK 465 ALA A 88 REMARK 465 THR A 89 REMARK 465 VAL A 90 REMARK 465 ALA A 91 REMARK 465 ALA A 92 REMARK 465 GLY A 93 REMARK 465 HIS A 94 REMARK 465 ALA A 95 REMARK 465 THR A 96 REMARK 465 LEU A 97 REMARK 465 ARG A 98 REMARK 465 ALA A 99 REMARK 465 HIS A 100 REMARK 465 LEU A 101 REMARK 465 ARG A 102 REMARK 465 GLU A 103 REMARK 465 ILE A 104 REMARK 465 LYS A 105 REMARK 465 VAL A 106 REMARK 465 GLU A 107 REMARK 465 ASN A 108 REMARK 465 ALA A 109 REMARK 465 ASP A 110 REMARK 465 THR A 331 REMARK 465 THR A 332 REMARK 465 LYS A 333 REMARK 465 ALA A 334 REMARK 465 ARG A 335 REMARK 465 ALA A 336 REMARK 465 THR A 337 REMARK 465 LEU A 459A REMARK 465 ALA A 459B REMARK 465 GLU A 459C REMARK 465 LEU A 459D REMARK 465 TYR A 459E REMARK 465 VAL A 459F REMARK 465 ARG A 459G REMARK 465 GLU A 459H REMARK 465 TYR A 459I REMARK 465 MET A 459J REMARK 465 ARG A 459K REMARK 465 GLU A 459L REMARK 465 GLN A 459M REMARK 465 ASP A 459N REMARK 465 ARG A 459O REMARK 465 LYS A 459P REMARK 465 PRO A 459Q REMARK 465 ARG A 459R REMARK 465 ASN A 459S REMARK 465 ALA A 459T REMARK 465 THR A 459U REMARK 465 PRO A 459V REMARK 465 ALA A 459W REMARK 465 PRO A 459X REMARK 465 LEU A 459Y REMARK 465 ARG A 459Z REMARK 465 GLU A 460A REMARK 465 ALA A 460B REMARK 465 PRO A 460C REMARK 465 SER A 460D REMARK 465 ALA A 460E REMARK 465 ASN A 460F REMARK 465 ALA A 460G REMARK 465 SER A 460H REMARK 465 ASP A 726 REMARK 465 ALA A 727 REMARK 465 ASN A 728 REMARK 465 ALA A 729 REMARK 465 ALA A 730 REMARK 465 GLY A 731 REMARK 465 GLY A 732 REMARK 465 GLY A 733 REMARK 465 SER A 734 REMARK 465 HIS A 735 REMARK 465 HIS A 736 REMARK 465 HIS A 737 REMARK 465 HIS A 738 REMARK 465 HIS A 739 REMARK 465 HIS A 740 REMARK 465 HIS A 741 REMARK 465 HIS A 742 REMARK 465 GLY A 743 REMARK 465 SER A 744 REMARK 465 ASP A 745 REMARK 465 TYR A 746 REMARK 465 LYS A 747 REMARK 465 ASP A 748 REMARK 465 ASP A 749 REMARK 465 ASP A 750 REMARK 465 ASP A 751 REMARK 465 LYS A 752 REMARK 465 ALA B 28 REMARK 465 PRO B 29 REMARK 465 ALA B 30 REMARK 465 ALA B 31 REMARK 465 PRO B 32 REMARK 465 ALA B 33 REMARK 465 ALA B 34 REMARK 465 PRO B 35 REMARK 465 ARG B 36 REMARK 465 ALA B 37 REMARK 465 SER B 38 REMARK 465 GLY B 39 REMARK 465 GLY B 40 REMARK 465 VAL B 41 REMARK 465 ALA B 42 REMARK 465 ALA B 43 REMARK 465 THR B 44 REMARK 465 VAL B 45 REMARK 465 ALA B 46 REMARK 465 ALA B 47 REMARK 465 ASN B 48 REMARK 465 GLY B 49 REMARK 465 GLY B 50 REMARK 465 PRO B 51 REMARK 465 ALA B 52 REMARK 465 SER B 53 REMARK 465 ARG B 54 REMARK 465 PRO B 55 REMARK 465 PRO B 56 REMARK 465 PRO B 57 REMARK 465 VAL B 58 REMARK 465 PRO B 59 REMARK 465 SER B 60 REMARK 465 PRO B 61 REMARK 465 ALA B 62 REMARK 465 THR B 63 REMARK 465 THR B 64 REMARK 465 LYS B 65 REMARK 465 ALA B 66 REMARK 465 ARG B 67 REMARK 465 LYS B 68 REMARK 465 ARG B 69 REMARK 465 LYS B 70 REMARK 465 THR B 71 REMARK 465 LYS B 72 REMARK 465 LYS B 73 REMARK 465 PRO B 74 REMARK 465 PRO B 75 REMARK 465 LYS B 76 REMARK 465 ARG B 77 REMARK 465 PRO B 78 REMARK 465 GLU B 79 REMARK 465 ALA B 80 REMARK 465 THR B 81 REMARK 465 PRO B 82 REMARK 465 PRO B 83 REMARK 465 PRO B 84 REMARK 465 ASP B 85 REMARK 465 ALA B 86 REMARK 465 ASN B 87 REMARK 465 ALA B 88 REMARK 465 THR B 89 REMARK 465 VAL B 90 REMARK 465 ALA B 91 REMARK 465 ALA B 92 REMARK 465 GLY B 93 REMARK 465 HIS B 94 REMARK 465 ALA B 95 REMARK 465 THR B 96 REMARK 465 LEU B 97 REMARK 465 ARG B 98 REMARK 465 ALA B 99 REMARK 465 HIS B 100 REMARK 465 LEU B 101 REMARK 465 ARG B 102 REMARK 465 GLU B 103 REMARK 465 ILE B 104 REMARK 465 LYS B 105 REMARK 465 VAL B 106 REMARK 465 GLU B 107 REMARK 465 ASN B 108 REMARK 465 ALA B 109 REMARK 465 THR B 331 REMARK 465 THR B 332 REMARK 465 LYS B 333 REMARK 465 ALA B 334 REMARK 465 ARG B 335 REMARK 465 ALA B 336 REMARK 465 GLU B 461A REMARK 465 LEU B 461B REMARK 465 TYR B 461C REMARK 465 VAL B 461D REMARK 465 ARG B 461E REMARK 465 GLU B 461F REMARK 465 TYR B 461G REMARK 465 MET B 461H REMARK 465 ARG B 461I REMARK 465 GLU B 461J REMARK 465 GLN B 461K REMARK 465 ASP B 461L REMARK 465 ARG B 461M REMARK 465 LYS B 461N REMARK 465 PRO B 461O REMARK 465 ARG B 461P REMARK 465 ASN B 461Q REMARK 465 ALA B 461R REMARK 465 THR B 461S REMARK 465 PRO B 461T REMARK 465 ALA B 461U REMARK 465 PRO B 461V REMARK 465 LEU B 461W REMARK 465 ARG B 461X REMARK 465 GLU B 461Y REMARK 465 ALA B 461Z REMARK 465 PRO B 462A REMARK 465 SER B 462B REMARK 465 ALA B 462C REMARK 465 ASN B 462D REMARK 465 ALA B 462E REMARK 465 ALA B 725 REMARK 465 ASP B 726 REMARK 465 ALA B 727 REMARK 465 ASN B 728 REMARK 465 ALA B 729 REMARK 465 ALA B 730 REMARK 465 GLY B 731 REMARK 465 GLY B 732 REMARK 465 GLY B 733 REMARK 465 SER B 734 REMARK 465 HIS B 735 REMARK 465 HIS B 736 REMARK 465 HIS B 737 REMARK 465 HIS B 738 REMARK 465 HIS B 739 REMARK 465 HIS B 740 REMARK 465 HIS B 741 REMARK 465 HIS B 742 REMARK 465 GLY B 743 REMARK 465 SER B 744 REMARK 465 ASP B 745 REMARK 465 TYR B 746 REMARK 465 LYS B 747 REMARK 465 ASP B 748 REMARK 465 ASP B 749 REMARK 465 ASP B 750 REMARK 465 ASP B 751 REMARK 465 LYS B 752 REMARK 465 ALA C 28 REMARK 465 PRO C 29 REMARK 465 ALA C 30 REMARK 465 ALA C 31 REMARK 465 PRO C 32 REMARK 465 ALA C 33 REMARK 465 ALA C 34 REMARK 465 PRO C 35 REMARK 465 ARG C 36 REMARK 465 ALA C 37 REMARK 465 SER C 38 REMARK 465 GLY C 39 REMARK 465 GLY C 40 REMARK 465 VAL C 41 REMARK 465 ALA C 42 REMARK 465 ALA C 43 REMARK 465 THR C 44 REMARK 465 VAL C 45 REMARK 465 ALA C 46 REMARK 465 ALA C 47 REMARK 465 ASN C 48 REMARK 465 GLY C 49 REMARK 465 GLY C 50 REMARK 465 PRO C 51 REMARK 465 ALA C 52 REMARK 465 SER C 53 REMARK 465 ARG C 54 REMARK 465 PRO C 55 REMARK 465 PRO C 56 REMARK 465 PRO C 57 REMARK 465 VAL C 58 REMARK 465 PRO C 59 REMARK 465 SER C 60 REMARK 465 PRO C 61 REMARK 465 ALA C 62 REMARK 465 THR C 63 REMARK 465 THR C 64 REMARK 465 LYS C 65 REMARK 465 ALA C 66 REMARK 465 ARG C 67 REMARK 465 LYS C 68 REMARK 465 ARG C 69 REMARK 465 LYS C 70 REMARK 465 THR C 71 REMARK 465 LYS C 72 REMARK 465 LYS C 73 REMARK 465 PRO C 74 REMARK 465 PRO C 75 REMARK 465 LYS C 76 REMARK 465 ARG C 77 REMARK 465 PRO C 78 REMARK 465 GLU C 79 REMARK 465 ALA C 80 REMARK 465 THR C 81 REMARK 465 PRO C 82 REMARK 465 PRO C 83 REMARK 465 PRO C 84 REMARK 465 ASP C 85 REMARK 465 ALA C 86 REMARK 465 ASN C 87 REMARK 465 ALA C 88 REMARK 465 THR C 89 REMARK 465 VAL C 90 REMARK 465 ALA C 91 REMARK 465 ALA C 92 REMARK 465 GLY C 93 REMARK 465 HIS C 94 REMARK 465 ALA C 95 REMARK 465 THR C 96 REMARK 465 LEU C 97 REMARK 465 ARG C 98 REMARK 465 ALA C 99 REMARK 465 HIS C 100 REMARK 465 LEU C 101 REMARK 465 ARG C 102 REMARK 465 GLU C 103 REMARK 465 ILE C 104 REMARK 465 LYS C 105 REMARK 465 VAL C 106 REMARK 465 GLU C 107 REMARK 465 ASN C 108 REMARK 465 ALA C 109 REMARK 465 ARG C 328 REMARK 465 ASP C 329 REMARK 465 LEU C 330 REMARK 465 THR C 331 REMARK 465 THR C 332 REMARK 465 LYS C 333 REMARK 465 ALA C 334 REMARK 465 ARG C 335 REMARK 465 ALA C 336 REMARK 465 LEU C 459A REMARK 465 ALA C 459B REMARK 465 GLU C 459C REMARK 465 LEU C 459D REMARK 465 TYR C 459E REMARK 465 VAL C 459F REMARK 465 ARG C 459G REMARK 465 GLU C 459H REMARK 465 TYR C 459I REMARK 465 MET C 459J REMARK 465 ARG C 459K REMARK 465 GLU C 459L REMARK 465 GLN C 459M REMARK 465 ASP C 459N REMARK 465 ARG C 459O REMARK 465 LYS C 459P REMARK 465 PRO C 459Q REMARK 465 ARG C 459R REMARK 465 ASN C 459S REMARK 465 ALA C 459T REMARK 465 THR C 459U REMARK 465 PRO C 459V REMARK 465 ALA C 459W REMARK 465 PRO C 459X REMARK 465 LEU C 459Y REMARK 465 ARG C 459Z REMARK 465 GLU C 460A REMARK 465 ALA C 460B REMARK 465 PRO C 460C REMARK 465 SER C 460D REMARK 465 ALA C 460E REMARK 465 ASN C 460F REMARK 465 ALA C 460G REMARK 465 ARG C 724 REMARK 465 ALA C 725 REMARK 465 ASP C 726 REMARK 465 ALA C 727 REMARK 465 ASN C 728 REMARK 465 ALA C 729 REMARK 465 ALA C 730 REMARK 465 GLY C 731 REMARK 465 GLY C 732 REMARK 465 GLY C 733 REMARK 465 SER C 734 REMARK 465 HIS C 735 REMARK 465 HIS C 736 REMARK 465 HIS C 737 REMARK 465 HIS C 738 REMARK 465 HIS C 739 REMARK 465 HIS C 740 REMARK 465 HIS C 741 REMARK 465 HIS C 742 REMARK 465 GLY C 743 REMARK 465 SER C 744 REMARK 465 ASP C 745 REMARK 465 TYR C 746 REMARK 465 LYS C 747 REMARK 465 ASP C 748 REMARK 465 ASP C 749 REMARK 465 ASP C 750 REMARK 465 ASP C 751 REMARK 465 LYS C 752 REMARK 465 HIS D 126 REMARK 465 HIS D 127 REMARK 465 HIS D 128 REMARK 465 HIS D 129 REMARK 465 HIS D 130 REMARK 465 HIS D 131 REMARK 465 HIS E 126 REMARK 465 HIS E 127 REMARK 465 HIS E 128 REMARK 465 HIS E 129 REMARK 465 HIS E 130 REMARK 465 HIS E 131 REMARK 465 HIS F 126 REMARK 465 HIS F 127 REMARK 465 HIS F 128 REMARK 465 HIS F 129 REMARK 465 HIS F 130 REMARK 465 HIS F 131 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT REMARK 500 REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT. REMARK 500 REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE REMARK 500 NZ LYS C 238 O HOH A 1508 0.40 REMARK 500 NZ LYS A 238 O HOH A 801 0.53 REMARK 500 CZ ARG C 415 O HOH C 801 1.15 REMARK 500 NZ LYS B 238 O HOH B 801 1.15 REMARK 500 CE LYS A 238 O HOH A 801 1.70 REMARK 500 NH2 ARG C 415 O HOH C 801 1.71 REMARK 500 CE LYS C 238 O HOH A 1508 1.75 REMARK 500 NH1 ARG C 415 O HOH C 801 1.75 REMARK 500 NH1 ARG A 724 O HOH A 802 1.79 REMARK 500 NE ARG C 415 O HOH C 801 1.79 REMARK 500 CE LYS B 238 O HOH B 1236 2.01 REMARK 500 NZ LYS B 238 O HOH B 802 2.01 REMARK 500 NH1 ARG C 415 O HOH C 802 2.02 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 PRO A 578 CA - N - CD ANGL. DEV. = -12.4 DEGREES REMARK 500 PRO B 578 CA - N - CD ANGL. DEV. = -12.4 DEGREES REMARK 500 PRO C 578 CA - N - CD ANGL. DEV. = -12.4 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ARG A 225 17.60 55.58 REMARK 500 HIS A 311 137.17 -172.58 REMARK 500 ASN A 620 58.16 37.59 REMARK 500 ARG A 724 -103.12 -80.36 REMARK 500 ARG B 225 16.60 58.44 REMARK 500 ALA B 426 26.00 -70.90 REMARK 500 ARG B 427 -19.14 -142.55 REMARK 500 ASN B 546 80.14 -156.94 REMARK 500 ASN B 580 30.23 -98.10 REMARK 500 SER B 656 -62.10 -93.75 REMARK 500 ARG C 225 19.34 56.77 REMARK 500 ASN C 546 86.11 -152.85 REMARK 500 LEU C 612 95.76 -68.08 REMARK 500 ALA E 77 -0.77 69.09 REMARK 500 ASN E 79 -1.73 69.54 REMARK 500 ARG E 102 55.86 -98.71 REMARK 500 THR F 109 161.78 61.84 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG A 418 0.13 SIDE CHAIN REMARK 500 ARG A 423 0.14 SIDE CHAIN REMARK 500 ARG A 427 0.19 SIDE CHAIN REMARK 500 ARG A 724 0.16 SIDE CHAIN REMARK 500 ARG B 423 0.14 SIDE CHAIN REMARK 500 ARG B 427 0.29 SIDE CHAIN REMARK 500 ARG C 423 0.13 SIDE CHAIN REMARK 500 ARG C 427 0.28 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 525 REMARK 525 SOLVENT REMARK 525 REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER; REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE REMARK 525 NUMBER; I=INSERTION CODE): REMARK 525 REMARK 525 M RES CSSEQI REMARK 525 HOH A2022 DISTANCE = 5.84 ANGSTROMS REMARK 525 HOH A2023 DISTANCE = 5.85 ANGSTROMS REMARK 525 HOH A2024 DISTANCE = 5.87 ANGSTROMS REMARK 525 HOH A2025 DISTANCE = 5.88 ANGSTROMS REMARK 525 HOH A2026 DISTANCE = 5.89 ANGSTROMS REMARK 525 HOH A2027 DISTANCE = 5.89 ANGSTROMS REMARK 525 HOH A2028 DISTANCE = 5.91 ANGSTROMS REMARK 525 HOH A2029 DISTANCE = 5.92 ANGSTROMS REMARK 525 HOH A2030 DISTANCE = 5.92 ANGSTROMS REMARK 525 HOH A2031 DISTANCE = 5.95 ANGSTROMS REMARK 525 HOH A2032 DISTANCE = 5.96 ANGSTROMS REMARK 525 HOH A2033 DISTANCE = 6.00 ANGSTROMS REMARK 525 HOH A2034 DISTANCE = 6.07 ANGSTROMS REMARK 525 HOH A2035 DISTANCE = 6.07 ANGSTROMS REMARK 525 HOH A2036 DISTANCE = 6.16 ANGSTROMS REMARK 525 HOH A2037 DISTANCE = 6.20 ANGSTROMS REMARK 525 HOH A2038 DISTANCE = 6.21 ANGSTROMS REMARK 525 HOH A2039 DISTANCE = 6.76 ANGSTROMS REMARK 525 HOH A2040 DISTANCE = 6.96 ANGSTROMS REMARK 525 HOH B2018 DISTANCE = 5.82 ANGSTROMS REMARK 525 HOH B2019 DISTANCE = 5.84 ANGSTROMS REMARK 525 HOH B2020 DISTANCE = 5.85 ANGSTROMS REMARK 525 HOH B2021 DISTANCE = 5.85 ANGSTROMS REMARK 525 HOH B2022 DISTANCE = 5.87 ANGSTROMS REMARK 525 HOH B2023 DISTANCE = 5.89 ANGSTROMS REMARK 525 HOH B2024 DISTANCE = 5.89 ANGSTROMS REMARK 525 HOH B2025 DISTANCE = 5.91 ANGSTROMS REMARK 525 HOH B2026 DISTANCE = 5.91 ANGSTROMS REMARK 525 HOH B2027 DISTANCE = 5.92 ANGSTROMS REMARK 525 HOH B2028 DISTANCE = 5.94 ANGSTROMS REMARK 525 HOH B2029 DISTANCE = 6.01 ANGSTROMS REMARK 525 HOH B2030 DISTANCE = 6.06 ANGSTROMS REMARK 525 HOH B2031 DISTANCE = 6.08 ANGSTROMS REMARK 525 HOH B2032 DISTANCE = 6.10 ANGSTROMS REMARK 525 HOH B2033 DISTANCE = 6.13 ANGSTROMS REMARK 525 HOH B2034 DISTANCE = 6.25 ANGSTROMS REMARK 525 HOH B2035 DISTANCE = 6.42 ANGSTROMS REMARK 525 HOH B2036 DISTANCE = 6.43 ANGSTROMS REMARK 525 HOH B2037 DISTANCE = 6.90 ANGSTROMS REMARK 525 HOH B2038 DISTANCE = 7.67 ANGSTROMS REMARK 525 HOH C2029 DISTANCE = 5.81 ANGSTROMS REMARK 525 HOH C2030 DISTANCE = 5.81 ANGSTROMS REMARK 525 HOH C2031 DISTANCE = 5.82 ANGSTROMS REMARK 525 HOH C2032 DISTANCE = 5.85 ANGSTROMS REMARK 525 HOH C2033 DISTANCE = 5.86 ANGSTROMS REMARK 525 HOH C2034 DISTANCE = 5.87 ANGSTROMS REMARK 525 HOH C2035 DISTANCE = 5.87 ANGSTROMS REMARK 525 HOH C2036 DISTANCE = 5.87 ANGSTROMS REMARK 525 HOH C2037 DISTANCE = 5.90 ANGSTROMS REMARK 525 HOH C2038 DISTANCE = 5.90 ANGSTROMS REMARK 525 HOH C2039 DISTANCE = 5.90 ANGSTROMS REMARK 525 HOH C2040 DISTANCE = 5.90 ANGSTROMS REMARK 525 HOH C2041 DISTANCE = 5.92 ANGSTROMS REMARK 525 HOH C2042 DISTANCE = 5.92 ANGSTROMS REMARK 525 HOH C2043 DISTANCE = 6.02 ANGSTROMS REMARK 525 HOH C2044 DISTANCE = 6.04 ANGSTROMS REMARK 525 HOH C2045 DISTANCE = 6.05 ANGSTROMS REMARK 525 HOH C2046 DISTANCE = 6.09 ANGSTROMS REMARK 525 HOH C2047 DISTANCE = 6.25 ANGSTROMS REMARK 525 HOH C2048 DISTANCE = 6.34 ANGSTROMS REMARK 525 HOH C2049 DISTANCE = 6.66 ANGSTROMS REMARK 525 HOH C2050 DISTANCE = 7.04 ANGSTROMS REMARK 525 HOH D 413 DISTANCE = 5.89 ANGSTROMS REMARK 525 HOH F 407 DISTANCE = 5.86 ANGSTROMS REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-48671 RELATED DB: EMDB REMARK 900 C6 HERPES VIRUS SIMPLEX NEUTRALIZING NANOBODY BOUND TO HSV REMARK 900 GLYCOPROTEIN GB DBREF 9MVU A 28 730 UNP P10211 GB_HHV11 28 730 DBREF 9MVU B 28 730 UNP P10211 GB_HHV11 28 730 DBREF 9MVU C 28 730 UNP P10211 GB_HHV11 28 730 DBREF 9MVU D 1 131 PDB 9MVU 9MVU 1 131 DBREF 9MVU E 1 131 PDB 9MVU 9MVU 1 131 DBREF 9MVU F 1 131 PDB 9MVU 9MVU 1 131 SEQADV 9MVU PRO A 29 UNP P10211 SER 29 CONFLICT SEQADV 9MVU ALA A 33 UNP P10211 SER 33 CONFLICT SEQADV 9MVU ALA A 34 UNP P10211 SER 34 CONFLICT SEQADV 9MVU ARG A 36 UNP P10211 GLY 36 CONFLICT SEQADV 9MVU ALA A 37 UNP P10211 THR 37 CONFLICT SEQADV 9MVU SER A 38 UNP P10211 PRO 38 CONFLICT SEQADV 9MVU GLY A 40 UNP P10211 VAL 40 CONFLICT SEQADV 9MVU VAL A 41 UNP P10211 ALA 41 CONFLICT SEQADV 9MVU VAL A 45 UNP P10211 GLN 45 CONFLICT SEQADV 9MVU SER A 53 UNP P10211 THR 53 CONFLICT SEQADV 9MVU ARG A 54 UNP P10211 PRO 54 CONFLICT SEQADV 9MVU PRO A 55 UNP P10211 ALA 55 CONFLICT SEQADV 9MVU VAL A 58 UNP P10211 ALA 58 CONFLICT SEQADV 9MVU SER A 60 UNP P10211 GLY 60 CONFLICT SEQADV 9MVU PRO A 61 UNP P10211 ALA 61 CONFLICT SEQADV 9MVU ALA A 62 UNP P10211 PRO 62 CONFLICT SEQADV 9MVU THR A 63 UNP P10211 PRO 63 CONFLICT SEQADV 9MVU LYS A 65 UNP P10211 GLY 65 CONFLICT SEQADV 9MVU ALA A 66 UNP P10211 ASP 66 CONFLICT SEQADV 9MVU ARG A 67 UNP P10211 PRO 67 CONFLICT SEQADV 9MVU ARG A 69 UNP P10211 PRO 69 CONFLICT SEQADV 9MVU THR A 71 UNP P10211 LYS 71 CONFLICT SEQADV 9MVU LYS A 72 UNP P10211 ASN 72 CONFLICT SEQADV 9MVU LYS A 73 UNP P10211 ARG 73 VARIANT SEQADV 9MVU PRO A 74 UNP P10211 LYS 74 CONFLICT SEQADV 9MVU ARG A 77 UNP P10211 PRO 77 CONFLICT SEQADV 9MVU GLU A 79 UNP P10211 LYS 79 CONFLICT SEQADV 9MVU ALA A 80 UNP P10211 PRO 80 CONFLICT SEQADV 9MVU THR A 81 UNP P10211 PRO 81 CONFLICT SEQADV 9MVU PRO A 82 UNP P10211 ARG 82 CONFLICT SEQADV 9MVU PRO A 84 UNP P10211 ALA 84 CONFLICT SEQADV 9MVU ASP A 85 UNP P10211 GLY 85 CONFLICT SEQADV 9MVU ALA A 86 UNP P10211 ASP 86 CONFLICT SEQADV 9MVU ALA A 99 UNP P10211 GLU 99 CONFLICT SEQADV 9MVU GLU A 103 UNP P10211 ASP 103 CONFLICT SEQADV 9MVU VAL A 106 UNP P10211 ALA 106 CONFLICT SEQADV 9MVU ALA A 109 UNP P10211 THR 109 CONFLICT SEQADV 9MVU MET A 218 UNP P10211 LEU 218 CONFLICT SEQADV 9MVU LYS A 238 UNP P10211 ASN 238 CONFLICT SEQADV 9MVU VAL A 239 UNP P10211 ALA 239 CONFLICT SEQADV 9MVU SER A 338 UNP P10211 ALA 338 CONFLICT SEQADV 9MVU ALA A 362 UNP P10211 SER 362 CONFLICT SEQADV 9MVU ALA A 378 UNP P10211 SER 378 CONFLICT SEQADV 9MVU SER A 403 UNP P10211 PRO 403 CONFLICT SEQADV 9MVU ARG A 415 UNP P10211 LYS 415 CONFLICT SEQADV 9MVU GLU A 419 UNP P10211 ASP 419 CONFLICT SEQADV 9MVU ILE A 421 UNP P10211 MET 421 CONFLICT SEQADV 9MVU MET A 424 UNP P10211 ILE 424 CONFLICT SEQADV 9MVU LYS A 428 UNP P10211 ARG 428 CONFLICT SEQADV 9MVU THR A 445 UNP P10211 ASN 445 CONFLICT SEQADV 9MVU TYR A 459I UNP P10211 HIS 468 CONFLICT SEQADV 9MVU MET A 459J UNP P10211 LEU 469 CONFLICT SEQADV 9MVU ASP A 459N UNP P10211 SER 473 CONFLICT SEQADV 9MVU PRO A 459Q UNP P10211 INSERTION SEQADV 9MVU ARG A 459R UNP P10211 INSERTION SEQADV 9MVU ASN A 459S UNP P10211 PRO 476 CONFLICT SEQADV 9MVU ALA A 459T UNP P10211 PRO 477 CONFLICT SEQADV 9MVU THR A 459U UNP P10211 ASN 478 CONFLICT SEQADV 9MVU ALA A 459W UNP P10211 THR 480 CONFLICT SEQADV 9MVU LEU A 459Y UNP P10211 PRO 482 CONFLICT SEQADV 9MVU ARG A 459Z UNP P10211 PRO 483 CONFLICT SEQADV 9MVU GLU A 460A UNP P10211 PRO 484 CONFLICT SEQADV 9MVU ALA A 460B UNP P10211 GLY 485 CONFLICT SEQADV 9MVU PRO A 460C UNP P10211 ALA 486 CONFLICT SEQADV 9MVU ILE A 524 UNP P10211 VAL 524 CONFLICT SEQADV 9MVU VAL A 526 UNP P10211 ILE 526 CONFLICT SEQADV 9MVU PRO A 578 UNP P10211 ALA 578 CONFLICT SEQADV 9MVU VAL A 589 UNP P10211 ILE 589 CONFLICT SEQADV 9MVU THR A 595 UNP P10211 ALA 595 CONFLICT SEQADV 9MVU ILE A 613 UNP P10211 VAL 613 CONFLICT SEQADV 9MVU LEU A 630 UNP P10211 ILE 630 CONFLICT SEQADV 9MVU ILE A 642 UNP P10211 THR 642 CONFLICT SEQADV 9MVU VAL A 664 UNP P10211 ILE 664 CONFLICT SEQADV 9MVU ARG A 724 UNP P10211 HIS 724 CONFLICT SEQADV 9MVU GLY A 731 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY A 732 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY A 733 UNP P10211 EXPRESSION TAG SEQADV 9MVU SER A 734 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 735 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 736 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 737 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 738 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 739 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 740 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 741 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS A 742 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY A 743 UNP P10211 EXPRESSION TAG SEQADV 9MVU SER A 744 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP A 745 UNP P10211 EXPRESSION TAG SEQADV 9MVU TYR A 746 UNP P10211 EXPRESSION TAG SEQADV 9MVU LYS A 747 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP A 748 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP A 749 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP A 750 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP A 751 UNP P10211 EXPRESSION TAG SEQADV 9MVU LYS A 752 UNP P10211 EXPRESSION TAG SEQADV 9MVU PRO B 29 UNP P10211 SER 29 CONFLICT SEQADV 9MVU ALA B 33 UNP P10211 SER 33 CONFLICT SEQADV 9MVU ALA B 34 UNP P10211 SER 34 CONFLICT SEQADV 9MVU ARG B 36 UNP P10211 GLY 36 CONFLICT SEQADV 9MVU ALA B 37 UNP P10211 THR 37 CONFLICT SEQADV 9MVU SER B 38 UNP P10211 PRO 38 CONFLICT SEQADV 9MVU GLY B 40 UNP P10211 VAL 40 CONFLICT SEQADV 9MVU VAL B 41 UNP P10211 ALA 41 CONFLICT SEQADV 9MVU VAL B 45 UNP P10211 GLN 45 CONFLICT SEQADV 9MVU SER B 53 UNP P10211 THR 53 CONFLICT SEQADV 9MVU ARG B 54 UNP P10211 PRO 54 CONFLICT SEQADV 9MVU PRO B 55 UNP P10211 ALA 55 CONFLICT SEQADV 9MVU VAL B 58 UNP P10211 ALA 58 CONFLICT SEQADV 9MVU SER B 60 UNP P10211 GLY 60 CONFLICT SEQADV 9MVU PRO B 61 UNP P10211 ALA 61 CONFLICT SEQADV 9MVU ALA B 62 UNP P10211 PRO 62 CONFLICT SEQADV 9MVU THR B 63 UNP P10211 PRO 63 CONFLICT SEQADV 9MVU LYS B 65 UNP P10211 GLY 65 CONFLICT SEQADV 9MVU ALA B 66 UNP P10211 ASP 66 CONFLICT SEQADV 9MVU ARG B 67 UNP P10211 PRO 67 CONFLICT SEQADV 9MVU ARG B 69 UNP P10211 PRO 69 CONFLICT SEQADV 9MVU THR B 71 UNP P10211 LYS 71 CONFLICT SEQADV 9MVU LYS B 72 UNP P10211 ASN 72 CONFLICT SEQADV 9MVU LYS B 73 UNP P10211 ARG 73 VARIANT SEQADV 9MVU PRO B 74 UNP P10211 LYS 74 CONFLICT SEQADV 9MVU ARG B 77 UNP P10211 PRO 77 CONFLICT SEQADV 9MVU GLU B 79 UNP P10211 LYS 79 CONFLICT SEQADV 9MVU ALA B 80 UNP P10211 PRO 80 CONFLICT SEQADV 9MVU THR B 81 UNP P10211 PRO 81 CONFLICT SEQADV 9MVU PRO B 82 UNP P10211 ARG 82 CONFLICT SEQADV 9MVU PRO B 84 UNP P10211 ALA 84 CONFLICT SEQADV 9MVU ASP B 85 UNP P10211 GLY 85 CONFLICT SEQADV 9MVU ALA B 86 UNP P10211 ASP 86 CONFLICT SEQADV 9MVU ALA B 99 UNP P10211 GLU 99 CONFLICT SEQADV 9MVU GLU B 103 UNP P10211 ASP 103 CONFLICT SEQADV 9MVU VAL B 106 UNP P10211 ALA 106 CONFLICT SEQADV 9MVU ALA B 109 UNP P10211 THR 109 CONFLICT SEQADV 9MVU MET B 218 UNP P10211 LEU 218 CONFLICT SEQADV 9MVU LYS B 238 UNP P10211 ASN 238 CONFLICT SEQADV 9MVU VAL B 239 UNP P10211 ALA 239 CONFLICT SEQADV 9MVU SER B 338 UNP P10211 ALA 338 CONFLICT SEQADV 9MVU ALA B 362 UNP P10211 SER 362 CONFLICT SEQADV 9MVU ALA B 378 UNP P10211 SER 378 CONFLICT SEQADV 9MVU SER B 403 UNP P10211 PRO 403 CONFLICT SEQADV 9MVU ARG B 415 UNP P10211 LYS 415 CONFLICT SEQADV 9MVU GLU B 419 UNP P10211 ASP 419 CONFLICT SEQADV 9MVU ILE B 421 UNP P10211 MET 421 CONFLICT SEQADV 9MVU MET B 424 UNP P10211 ILE 424 CONFLICT SEQADV 9MVU LYS B 428 UNP P10211 ARG 428 CONFLICT SEQADV 9MVU THR B 445 UNP P10211 ASN 445 CONFLICT SEQADV 9MVU TYR B 461G UNP P10211 HIS 468 CONFLICT SEQADV 9MVU MET B 461H UNP P10211 LEU 469 CONFLICT SEQADV 9MVU ASP B 461L UNP P10211 SER 473 CONFLICT SEQADV 9MVU PRO B 461O UNP P10211 INSERTION SEQADV 9MVU ARG B 461P UNP P10211 INSERTION SEQADV 9MVU ASN B 461Q UNP P10211 PRO 476 CONFLICT SEQADV 9MVU ALA B 461R UNP P10211 PRO 477 CONFLICT SEQADV 9MVU THR B 461S UNP P10211 ASN 478 CONFLICT SEQADV 9MVU ALA B 461U UNP P10211 THR 480 CONFLICT SEQADV 9MVU LEU B 461W UNP P10211 PRO 482 CONFLICT SEQADV 9MVU ARG B 461X UNP P10211 PRO 483 CONFLICT SEQADV 9MVU GLU B 461Y UNP P10211 PRO 484 CONFLICT SEQADV 9MVU ALA B 461Z UNP P10211 GLY 485 CONFLICT SEQADV 9MVU PRO B 462A UNP P10211 ALA 486 CONFLICT SEQADV 9MVU ILE B 524 UNP P10211 VAL 524 CONFLICT SEQADV 9MVU VAL B 526 UNP P10211 ILE 526 CONFLICT SEQADV 9MVU PRO B 578 UNP P10211 ALA 578 CONFLICT SEQADV 9MVU VAL B 589 UNP P10211 ILE 589 CONFLICT SEQADV 9MVU THR B 595 UNP P10211 ALA 595 CONFLICT SEQADV 9MVU ILE B 613 UNP P10211 VAL 613 CONFLICT SEQADV 9MVU LEU B 630 UNP P10211 ILE 630 CONFLICT SEQADV 9MVU ILE B 642 UNP P10211 THR 642 CONFLICT SEQADV 9MVU VAL B 664 UNP P10211 ILE 664 CONFLICT SEQADV 9MVU ARG B 724 UNP P10211 HIS 724 CONFLICT SEQADV 9MVU GLY B 731 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY B 732 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY B 733 UNP P10211 EXPRESSION TAG SEQADV 9MVU SER B 734 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 735 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 736 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 737 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 738 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 739 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 740 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 741 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS B 742 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY B 743 UNP P10211 EXPRESSION TAG SEQADV 9MVU SER B 744 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP B 745 UNP P10211 EXPRESSION TAG SEQADV 9MVU TYR B 746 UNP P10211 EXPRESSION TAG SEQADV 9MVU LYS B 747 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP B 748 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP B 749 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP B 750 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP B 751 UNP P10211 EXPRESSION TAG SEQADV 9MVU LYS B 752 UNP P10211 EXPRESSION TAG SEQADV 9MVU PRO C 29 UNP P10211 SER 29 CONFLICT SEQADV 9MVU ALA C 33 UNP P10211 SER 33 CONFLICT SEQADV 9MVU ALA C 34 UNP P10211 SER 34 CONFLICT SEQADV 9MVU ARG C 36 UNP P10211 GLY 36 CONFLICT SEQADV 9MVU ALA C 37 UNP P10211 THR 37 CONFLICT SEQADV 9MVU SER C 38 UNP P10211 PRO 38 CONFLICT SEQADV 9MVU GLY C 40 UNP P10211 VAL 40 CONFLICT SEQADV 9MVU VAL C 41 UNP P10211 ALA 41 CONFLICT SEQADV 9MVU VAL C 45 UNP P10211 GLN 45 CONFLICT SEQADV 9MVU SER C 53 UNP P10211 THR 53 CONFLICT SEQADV 9MVU ARG C 54 UNP P10211 PRO 54 CONFLICT SEQADV 9MVU PRO C 55 UNP P10211 ALA 55 CONFLICT SEQADV 9MVU VAL C 58 UNP P10211 ALA 58 CONFLICT SEQADV 9MVU SER C 60 UNP P10211 GLY 60 CONFLICT SEQADV 9MVU PRO C 61 UNP P10211 ALA 61 CONFLICT SEQADV 9MVU ALA C 62 UNP P10211 PRO 62 CONFLICT SEQADV 9MVU THR C 63 UNP P10211 PRO 63 CONFLICT SEQADV 9MVU LYS C 65 UNP P10211 GLY 65 CONFLICT SEQADV 9MVU ALA C 66 UNP P10211 ASP 66 CONFLICT SEQADV 9MVU ARG C 67 UNP P10211 PRO 67 CONFLICT SEQADV 9MVU ARG C 69 UNP P10211 PRO 69 CONFLICT SEQADV 9MVU THR C 71 UNP P10211 LYS 71 CONFLICT SEQADV 9MVU LYS C 72 UNP P10211 ASN 72 CONFLICT SEQADV 9MVU LYS C 73 UNP P10211 ARG 73 VARIANT SEQADV 9MVU PRO C 74 UNP P10211 LYS 74 CONFLICT SEQADV 9MVU ARG C 77 UNP P10211 PRO 77 CONFLICT SEQADV 9MVU GLU C 79 UNP P10211 LYS 79 CONFLICT SEQADV 9MVU ALA C 80 UNP P10211 PRO 80 CONFLICT SEQADV 9MVU THR C 81 UNP P10211 PRO 81 CONFLICT SEQADV 9MVU PRO C 82 UNP P10211 ARG 82 CONFLICT SEQADV 9MVU PRO C 84 UNP P10211 ALA 84 CONFLICT SEQADV 9MVU ASP C 85 UNP P10211 GLY 85 CONFLICT SEQADV 9MVU ALA C 86 UNP P10211 ASP 86 CONFLICT SEQADV 9MVU ALA C 99 UNP P10211 GLU 99 CONFLICT SEQADV 9MVU GLU C 103 UNP P10211 ASP 103 CONFLICT SEQADV 9MVU VAL C 106 UNP P10211 ALA 106 CONFLICT SEQADV 9MVU ALA C 109 UNP P10211 THR 109 CONFLICT SEQADV 9MVU MET C 218 UNP P10211 LEU 218 CONFLICT SEQADV 9MVU LYS C 238 UNP P10211 ASN 238 CONFLICT SEQADV 9MVU VAL C 239 UNP P10211 ALA 239 CONFLICT SEQADV 9MVU SER C 338 UNP P10211 ALA 338 CONFLICT SEQADV 9MVU ALA C 362 UNP P10211 SER 362 CONFLICT SEQADV 9MVU ALA C 378 UNP P10211 SER 378 CONFLICT SEQADV 9MVU SER C 403 UNP P10211 PRO 403 CONFLICT SEQADV 9MVU ARG C 415 UNP P10211 LYS 415 CONFLICT SEQADV 9MVU GLU C 419 UNP P10211 ASP 419 CONFLICT SEQADV 9MVU ILE C 421 UNP P10211 MET 421 CONFLICT SEQADV 9MVU MET C 424 UNP P10211 ILE 424 CONFLICT SEQADV 9MVU LYS C 428 UNP P10211 ARG 428 CONFLICT SEQADV 9MVU THR C 445 UNP P10211 ASN 445 CONFLICT SEQADV 9MVU TYR C 459I UNP P10211 HIS 468 CONFLICT SEQADV 9MVU MET C 459J UNP P10211 LEU 469 CONFLICT SEQADV 9MVU ASP C 459N UNP P10211 SER 473 CONFLICT SEQADV 9MVU PRO C 459Q UNP P10211 INSERTION SEQADV 9MVU ARG C 459R UNP P10211 INSERTION SEQADV 9MVU ASN C 459S UNP P10211 PRO 476 CONFLICT SEQADV 9MVU ALA C 459T UNP P10211 PRO 477 CONFLICT SEQADV 9MVU THR C 459U UNP P10211 ASN 478 CONFLICT SEQADV 9MVU ALA C 459W UNP P10211 THR 480 CONFLICT SEQADV 9MVU LEU C 459Y UNP P10211 PRO 482 CONFLICT SEQADV 9MVU ARG C 459Z UNP P10211 PRO 483 CONFLICT SEQADV 9MVU GLU C 460A UNP P10211 PRO 484 CONFLICT SEQADV 9MVU ALA C 460B UNP P10211 GLY 485 CONFLICT SEQADV 9MVU PRO C 460C UNP P10211 ALA 486 CONFLICT SEQADV 9MVU ILE C 524 UNP P10211 VAL 524 CONFLICT SEQADV 9MVU VAL C 526 UNP P10211 ILE 526 CONFLICT SEQADV 9MVU PRO C 578 UNP P10211 ALA 578 CONFLICT SEQADV 9MVU VAL C 589 UNP P10211 ILE 589 CONFLICT SEQADV 9MVU THR C 595 UNP P10211 ALA 595 CONFLICT SEQADV 9MVU ILE C 613 UNP P10211 VAL 613 CONFLICT SEQADV 9MVU LEU C 630 UNP P10211 ILE 630 CONFLICT SEQADV 9MVU ILE C 642 UNP P10211 THR 642 CONFLICT SEQADV 9MVU VAL C 664 UNP P10211 ILE 664 CONFLICT SEQADV 9MVU ARG C 724 UNP P10211 HIS 724 CONFLICT SEQADV 9MVU GLY C 731 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY C 732 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY C 733 UNP P10211 EXPRESSION TAG SEQADV 9MVU SER C 734 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 735 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 736 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 737 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 738 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 739 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 740 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 741 UNP P10211 EXPRESSION TAG SEQADV 9MVU HIS C 742 UNP P10211 EXPRESSION TAG SEQADV 9MVU GLY C 743 UNP P10211 EXPRESSION TAG SEQADV 9MVU SER C 744 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP C 745 UNP P10211 EXPRESSION TAG SEQADV 9MVU TYR C 746 UNP P10211 EXPRESSION TAG SEQADV 9MVU LYS C 747 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP C 748 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP C 749 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP C 750 UNP P10211 EXPRESSION TAG SEQADV 9MVU ASP C 751 UNP P10211 EXPRESSION TAG SEQADV 9MVU LYS C 752 UNP P10211 EXPRESSION TAG SEQRES 1 A 727 ALA PRO ALA ALA PRO ALA ALA PRO ARG ALA SER GLY GLY SEQRES 2 A 727 VAL ALA ALA THR VAL ALA ALA ASN GLY GLY PRO ALA SER SEQRES 3 A 727 ARG PRO PRO PRO VAL PRO SER PRO ALA THR THR LYS ALA SEQRES 4 A 727 ARG LYS ARG LYS THR LYS LYS PRO PRO LYS ARG PRO GLU SEQRES 5 A 727 ALA THR PRO PRO PRO ASP ALA ASN ALA THR VAL ALA ALA SEQRES 6 A 727 GLY HIS ALA THR LEU ARG ALA HIS LEU ARG GLU ILE LYS SEQRES 7 A 727 VAL GLU ASN ALA ASP ALA ASN PHE TYR VAL CYS PRO PRO SEQRES 8 A 727 PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO ARG SEQRES 9 A 727 ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR GLU SEQRES 10 A 727 GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO TYR SEQRES 11 A 727 LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR VAL SEQRES 12 A 727 SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE MET SEQRES 13 A 727 GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU GLU SEQRES 14 A 727 VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SER SEQRES 15 A 727 THR ALA LYS TYR VAL ARG ASN ASN MET GLU THR THR ALA SEQRES 16 A 727 PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU LYS SEQRES 17 A 727 PRO ALA LYS VAL ALA THR ARG THR SER ARG GLY TRP HIS SEQRES 18 A 727 THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU ALA SEQRES 19 A 727 PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL GLU SEQRES 20 A 727 GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU PHE SEQRES 21 A 727 VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO PHE SEQRES 22 A 727 TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SER SEQRES 23 A 727 TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE TYR SEQRES 24 A 727 ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR SER PRO SEQRES 25 A 727 THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR VAL SEQRES 26 A 727 ALA TRP ASP TRP VAL PRO LYS ARG PRO ALA VAL CYS THR SEQRES 27 A 727 MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG ALA SEQRES 28 A 727 GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA ILE SEQRES 29 A 727 SER THR THR PHE THR THR ASN LEU THR GLU TYR SER LEU SEQRES 30 A 727 SER ARG VAL ASP LEU GLY ASP CYS ILE GLY ARG ASP ALA SEQRES 31 A 727 ARG GLU ALA ILE ASP ARG MET PHE ALA ARG LYS TYR ASN SEQRES 32 A 727 ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR LEU SEQRES 33 A 727 ALA THR GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU LEU SEQRES 34 A 727 SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU TYR MET SEQRES 35 A 727 ARG GLU GLN ASP ARG LYS PRO ARG ASN ALA THR PRO ALA SEQRES 36 A 727 PRO LEU ARG GLU ALA PRO SER ALA ASN ALA SER VAL GLU SEQRES 37 A 727 ARG ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU SEQRES 38 A 727 GLN PHE THR TYR ASN HIS ILE GLN ARG HIS VAL ASN ASP SEQRES 39 A 727 MET LEU GLY ARG ILE ALA VAL ALA TRP CYS GLU LEU GLN SEQRES 40 A 727 ASN HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU SEQRES 41 A 727 ASN PRO ASN ALA ILE ALA SER ALA THR VAL GLY ARG ARG SEQRES 42 A 727 VAL SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER SEQRES 43 A 727 THR CYS VAL PRO VAL ALA PRO ASP ASN VAL ILE VAL GLN SEQRES 44 A 727 ASN SER MET ARG VAL SER SER ARG PRO GLY THR CYS TYR SEQRES 45 A 727 SER ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY SEQRES 46 A 727 PRO LEU ILE GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU SEQRES 47 A 727 ARG LEU THR ARG ASP ALA LEU GLU PRO CYS THR VAL GLY SEQRES 48 A 727 HIS ARG ARG TYR PHE ILE PHE GLY GLY GLY TYR VAL TYR SEQRES 49 A 727 PHE GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA SEQRES 50 A 727 ASP VAL THR THR VAL SER THR PHE ILE ASP LEU ASN ILE SEQRES 51 A 727 THR MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL SEQRES 52 A 727 TYR THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP SEQRES 53 A 727 TYR THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU SEQRES 54 A 727 ARG PHE ALA ASP ILE ASP THR VAL ILE ARG ALA ASP ALA SEQRES 55 A 727 ASN ALA ALA GLY GLY GLY SER HIS HIS HIS HIS HIS HIS SEQRES 56 A 727 HIS HIS GLY SER ASP TYR LYS ASP ASP ASP ASP LYS SEQRES 1 B 727 ALA PRO ALA ALA PRO ALA ALA PRO ARG ALA SER GLY GLY SEQRES 2 B 727 VAL ALA ALA THR VAL ALA ALA ASN GLY GLY PRO ALA SER SEQRES 3 B 727 ARG PRO PRO PRO VAL PRO SER PRO ALA THR THR LYS ALA SEQRES 4 B 727 ARG LYS ARG LYS THR LYS LYS PRO PRO LYS ARG PRO GLU SEQRES 5 B 727 ALA THR PRO PRO PRO ASP ALA ASN ALA THR VAL ALA ALA SEQRES 6 B 727 GLY HIS ALA THR LEU ARG ALA HIS LEU ARG GLU ILE LYS SEQRES 7 B 727 VAL GLU ASN ALA ASP ALA ASN PHE TYR VAL CYS PRO PRO SEQRES 8 B 727 PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO ARG SEQRES 9 B 727 ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR GLU SEQRES 10 B 727 GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO TYR SEQRES 11 B 727 LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR VAL SEQRES 12 B 727 SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE MET SEQRES 13 B 727 GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU GLU SEQRES 14 B 727 VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SER SEQRES 15 B 727 THR ALA LYS TYR VAL ARG ASN ASN MET GLU THR THR ALA SEQRES 16 B 727 PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU LYS SEQRES 17 B 727 PRO ALA LYS VAL ALA THR ARG THR SER ARG GLY TRP HIS SEQRES 18 B 727 THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU ALA SEQRES 19 B 727 PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL GLU SEQRES 20 B 727 GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU PHE SEQRES 21 B 727 VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO PHE SEQRES 22 B 727 TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SER SEQRES 23 B 727 TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE TYR SEQRES 24 B 727 ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR SER PRO SEQRES 25 B 727 THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR VAL SEQRES 26 B 727 ALA TRP ASP TRP VAL PRO LYS ARG PRO ALA VAL CYS THR SEQRES 27 B 727 MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG ALA SEQRES 28 B 727 GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA ILE SEQRES 29 B 727 SER THR THR PHE THR THR ASN LEU THR GLU TYR SER LEU SEQRES 30 B 727 SER ARG VAL ASP LEU GLY ASP CYS ILE GLY ARG ASP ALA SEQRES 31 B 727 ARG GLU ALA ILE ASP ARG MET PHE ALA ARG LYS TYR ASN SEQRES 32 B 727 ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR LEU SEQRES 33 B 727 ALA THR GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU LEU SEQRES 34 B 727 SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU TYR MET SEQRES 35 B 727 ARG GLU GLN ASP ARG LYS PRO ARG ASN ALA THR PRO ALA SEQRES 36 B 727 PRO LEU ARG GLU ALA PRO SER ALA ASN ALA SER VAL GLU SEQRES 37 B 727 ARG ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU SEQRES 38 B 727 GLN PHE THR TYR ASN HIS ILE GLN ARG HIS VAL ASN ASP SEQRES 39 B 727 MET LEU GLY ARG ILE ALA VAL ALA TRP CYS GLU LEU GLN SEQRES 40 B 727 ASN HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU SEQRES 41 B 727 ASN PRO ASN ALA ILE ALA SER ALA THR VAL GLY ARG ARG SEQRES 42 B 727 VAL SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER SEQRES 43 B 727 THR CYS VAL PRO VAL ALA PRO ASP ASN VAL ILE VAL GLN SEQRES 44 B 727 ASN SER MET ARG VAL SER SER ARG PRO GLY THR CYS TYR SEQRES 45 B 727 SER ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY SEQRES 46 B 727 PRO LEU ILE GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU SEQRES 47 B 727 ARG LEU THR ARG ASP ALA LEU GLU PRO CYS THR VAL GLY SEQRES 48 B 727 HIS ARG ARG TYR PHE ILE PHE GLY GLY GLY TYR VAL TYR SEQRES 49 B 727 PHE GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA SEQRES 50 B 727 ASP VAL THR THR VAL SER THR PHE ILE ASP LEU ASN ILE SEQRES 51 B 727 THR MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL SEQRES 52 B 727 TYR THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP SEQRES 53 B 727 TYR THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU SEQRES 54 B 727 ARG PHE ALA ASP ILE ASP THR VAL ILE ARG ALA ASP ALA SEQRES 55 B 727 ASN ALA ALA GLY GLY GLY SER HIS HIS HIS HIS HIS HIS SEQRES 56 B 727 HIS HIS GLY SER ASP TYR LYS ASP ASP ASP ASP LYS SEQRES 1 C 727 ALA PRO ALA ALA PRO ALA ALA PRO ARG ALA SER GLY GLY SEQRES 2 C 727 VAL ALA ALA THR VAL ALA ALA ASN GLY GLY PRO ALA SER SEQRES 3 C 727 ARG PRO PRO PRO VAL PRO SER PRO ALA THR THR LYS ALA SEQRES 4 C 727 ARG LYS ARG LYS THR LYS LYS PRO PRO LYS ARG PRO GLU SEQRES 5 C 727 ALA THR PRO PRO PRO ASP ALA ASN ALA THR VAL ALA ALA SEQRES 6 C 727 GLY HIS ALA THR LEU ARG ALA HIS LEU ARG GLU ILE LYS SEQRES 7 C 727 VAL GLU ASN ALA ASP ALA ASN PHE TYR VAL CYS PRO PRO SEQRES 8 C 727 PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO ARG SEQRES 9 C 727 ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR GLU SEQRES 10 C 727 GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO TYR SEQRES 11 C 727 LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR VAL SEQRES 12 C 727 SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE MET SEQRES 13 C 727 GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU GLU SEQRES 14 C 727 VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SER SEQRES 15 C 727 THR ALA LYS TYR VAL ARG ASN ASN MET GLU THR THR ALA SEQRES 16 C 727 PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU LYS SEQRES 17 C 727 PRO ALA LYS VAL ALA THR ARG THR SER ARG GLY TRP HIS SEQRES 18 C 727 THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU ALA SEQRES 19 C 727 PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL GLU SEQRES 20 C 727 GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU PHE SEQRES 21 C 727 VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO PHE SEQRES 22 C 727 TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SER SEQRES 23 C 727 TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE TYR SEQRES 24 C 727 ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR SER PRO SEQRES 25 C 727 THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR VAL SEQRES 26 C 727 ALA TRP ASP TRP VAL PRO LYS ARG PRO ALA VAL CYS THR SEQRES 27 C 727 MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG ALA SEQRES 28 C 727 GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA ILE SEQRES 29 C 727 SER THR THR PHE THR THR ASN LEU THR GLU TYR SER LEU SEQRES 30 C 727 SER ARG VAL ASP LEU GLY ASP CYS ILE GLY ARG ASP ALA SEQRES 31 C 727 ARG GLU ALA ILE ASP ARG MET PHE ALA ARG LYS TYR ASN SEQRES 32 C 727 ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR LEU SEQRES 33 C 727 ALA THR GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU LEU SEQRES 34 C 727 SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU TYR MET SEQRES 35 C 727 ARG GLU GLN ASP ARG LYS PRO ARG ASN ALA THR PRO ALA SEQRES 36 C 727 PRO LEU ARG GLU ALA PRO SER ALA ASN ALA SER VAL GLU SEQRES 37 C 727 ARG ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU SEQRES 38 C 727 GLN PHE THR TYR ASN HIS ILE GLN ARG HIS VAL ASN ASP SEQRES 39 C 727 MET LEU GLY ARG ILE ALA VAL ALA TRP CYS GLU LEU GLN SEQRES 40 C 727 ASN HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU SEQRES 41 C 727 ASN PRO ASN ALA ILE ALA SER ALA THR VAL GLY ARG ARG SEQRES 42 C 727 VAL SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER SEQRES 43 C 727 THR CYS VAL PRO VAL ALA PRO ASP ASN VAL ILE VAL GLN SEQRES 44 C 727 ASN SER MET ARG VAL SER SER ARG PRO GLY THR CYS TYR SEQRES 45 C 727 SER ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY SEQRES 46 C 727 PRO LEU ILE GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU SEQRES 47 C 727 ARG LEU THR ARG ASP ALA LEU GLU PRO CYS THR VAL GLY SEQRES 48 C 727 HIS ARG ARG TYR PHE ILE PHE GLY GLY GLY TYR VAL TYR SEQRES 49 C 727 PHE GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA SEQRES 50 C 727 ASP VAL THR THR VAL SER THR PHE ILE ASP LEU ASN ILE SEQRES 51 C 727 THR MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL SEQRES 52 C 727 TYR THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP SEQRES 53 C 727 TYR THR GLU VAL GLN ARG ARG ASN GLN LEU HIS ASP LEU SEQRES 54 C 727 ARG PHE ALA ASP ILE ASP THR VAL ILE ARG ALA ASP ALA SEQRES 55 C 727 ASN ALA ALA GLY GLY GLY SER HIS HIS HIS HIS HIS HIS SEQRES 56 C 727 HIS HIS GLY SER ASP TYR LYS ASP ASP ASP ASP LYS SEQRES 1 D 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 D 131 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 D 131 VAL THR PHE GLY SER ASN ARG MET GLY TRP PHE ARG GLN SEQRES 4 D 131 ALA PRO GLY LYS GLY ARG GLU PHE VAL ALA THR HIS SER SEQRES 5 D 131 THR TYR PHE ASN PRO ALA ARG THR ASN TYR ALA ASP SER SEQRES 6 D 131 VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLY SEQRES 7 D 131 ASN SER VAL TYR LEU GLN MET ASN SER LEU ARG ALA GLU SEQRES 8 D 131 ASP THR ALA VAL TYR TYR CYS LEU PHE ASP ARG ARG LEU SEQRES 9 D 131 GLY THR VAL VAL THR GLY PRO GLU GLY TYR TRP GLY GLN SEQRES 10 D 131 GLY THR GLN VAL THR VAL SER SER HIS HIS HIS HIS HIS SEQRES 11 D 131 HIS SEQRES 1 E 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 E 131 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 E 131 VAL THR PHE GLY SER ASN ARG MET GLY TRP PHE ARG GLN SEQRES 4 E 131 ALA PRO GLY LYS GLY ARG GLU PHE VAL ALA THR HIS SER SEQRES 5 E 131 THR TYR PHE ASN PRO ALA ARG THR ASN TYR ALA ASP SER SEQRES 6 E 131 VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLY SEQRES 7 E 131 ASN SER VAL TYR LEU GLN MET ASN SER LEU ARG ALA GLU SEQRES 8 E 131 ASP THR ALA VAL TYR TYR CYS LEU PHE ASP ARG ARG LEU SEQRES 9 E 131 GLY THR VAL VAL THR GLY PRO GLU GLY TYR TRP GLY GLN SEQRES 10 E 131 GLY THR GLN VAL THR VAL SER SER HIS HIS HIS HIS HIS SEQRES 11 E 131 HIS SEQRES 1 F 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 F 131 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 F 131 VAL THR PHE GLY SER ASN ARG MET GLY TRP PHE ARG GLN SEQRES 4 F 131 ALA PRO GLY LYS GLY ARG GLU PHE VAL ALA THR HIS SER SEQRES 5 F 131 THR TYR PHE ASN PRO ALA ARG THR ASN TYR ALA ASP SER SEQRES 6 F 131 VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA GLY SEQRES 7 F 131 ASN SER VAL TYR LEU GLN MET ASN SER LEU ARG ALA GLU SEQRES 8 F 131 ASP THR ALA VAL TYR TYR CYS LEU PHE ASP ARG ARG LEU SEQRES 9 F 131 GLY THR VAL VAL THR GLY PRO GLU GLY TYR TRP GLY GLN SEQRES 10 F 131 GLY THR GLN VAL THR VAL SER SER HIS HIS HIS HIS HIS SEQRES 11 F 131 HIS FORMUL 7 HOH *4362(H2 O) HELIX 1 AA1 PRO A 193 LYS A 200 1 8 HELIX 2 AA2 LYS A 200 GLY A 205 1 6 HELIX 3 AA3 ARG A 225 ASP A 227 5 3 HELIX 4 AA4 GLY A 306 GLU A 310 5 5 HELIX 5 AA5 ALA A 315 ASP A 317 5 3 HELIX 6 AA6 SER A 403 VAL A 407 5 5 HELIX 7 AA7 ASP A 411 TYR A 429 1 19 HELIX 8 AA8 ILE A 501 ASN A 546 1 46 HELIX 9 AA9 ASN A 546 GLY A 556 1 11 HELIX 10 AB1 ALA A 577 VAL A 581 5 5 HELIX 11 AB2 ALA A 662 VAL A 664 5 3 HELIX 12 AB3 THR A 690 SER A 697 1 8 HELIX 13 AB4 ASP A 701 GLN A 710 1 10 HELIX 14 AB5 LEU A 711 ALA A 717 1 7 HELIX 15 AB6 PRO B 193 LYS B 200 1 8 HELIX 16 AB7 LYS B 200 GLY B 205 1 6 HELIX 17 AB8 ARG B 225 ASP B 227 5 3 HELIX 18 AB9 GLY B 306 GLU B 310 5 5 HELIX 19 AC1 ALA B 315 ASP B 317 5 3 HELIX 20 AC2 PRO B 358 VAL B 363 1 6 HELIX 21 AC3 SER B 403 VAL B 407 5 5 HELIX 22 AC4 ASP B 411 TYR B 429 1 19 HELIX 23 AC5 ILE B 501 ASN B 546 1 46 HELIX 24 AC6 ASN B 546 GLY B 556 1 11 HELIX 25 AC7 ALA B 577 ASP B 579 5 3 HELIX 26 AC8 SER B 660 VAL B 664 5 5 HELIX 27 AC9 THR B 690 SER B 697 1 8 HELIX 28 AD1 ASP B 701 GLN B 710 1 10 HELIX 29 AD2 LEU B 711 ALA B 717 1 7 HELIX 30 AD3 PRO C 193 LYS C 200 1 8 HELIX 31 AD4 LYS C 200 GLY C 205 1 6 HELIX 32 AD5 ARG C 225 ASP C 227 5 3 HELIX 33 AD6 GLY C 306 GLU C 310 5 5 HELIX 34 AD7 ALA C 315 ASP C 317 5 3 HELIX 35 AD8 PRO C 358 VAL C 363 1 6 HELIX 36 AD9 SER C 403 VAL C 407 5 5 HELIX 37 AE1 ASP C 411 TYR C 429 1 19 HELIX 38 AE2 ILE C 501 ASN C 546 1 46 HELIX 39 AE3 ASN C 546 GLY C 556 1 11 HELIX 40 AE4 ALA C 577 ASP C 579 5 3 HELIX 41 AE5 SER C 660 VAL C 664 5 5 HELIX 42 AE6 THR C 690 SER C 697 1 8 HELIX 43 AE7 ASP C 701 GLN C 710 1 10 HELIX 44 AE8 LEU C 711 ALA C 717 1 7 HELIX 45 AE9 ARG D 89 THR D 93 5 5 HELIX 46 AF1 ARG E 89 THR E 93 5 5 HELIX 47 AF2 ARG F 89 THR F 93 5 5 SHEET 1 AA1 6 VAL A 574 VAL A 576 0 SHEET 2 AA1 6 PHE A 113 VAL A 115 -1 N VAL A 115 O VAL A 574 SHEET 3 AA1 6 GLU A 622 ARG A 624 1 O LEU A 623 N TYR A 114 SHEET 4 AA1 6 ILE A 613 LEU A 617 -1 N GLN A 616 O ARG A 624 SHEET 5 AA1 6 LEU A 601 PHE A 604 -1 N PHE A 604 O ILE A 613 SHEET 6 AA1 6 ILE A 582 VAL A 583 -1 N ILE A 582 O SER A 603 SHEET 1 AA2 4 VAL A 559 LEU A 564 0 SHEET 2 AA2 4 VAL A 567 THR A 572 -1 O SER A 571 N SER A 560 SHEET 3 AA2 4 THR A 123 PHE A 127 -1 N VAL A 125 O MET A 568 SHEET 4 AA2 4 THR C 665 VAL C 667 1 O VAL C 667 N GLN A 126 SHEET 1 AA3 8 HIS A 433 LYS A 435 0 SHEET 2 AA3 8 PHE A 448 SER A 457 -1 O LEU A 456 N ILE A 434 SHEET 3 AA3 8 GLN A 440 ALA A 444 -1 N ALA A 444 O PHE A 448 SHEET 4 AA3 8 THR A 393 ASN A 398 -1 N ASN A 398 O LEU A 443 SHEET 5 AA3 8 SER A 383 SER A 388 -1 N PHE A 386 O PHE A 395 SHEET 6 AA3 8 MET A 366 TYR A 380 -1 N LEU A 376 O SER A 387 SHEET 7 AA3 8 THR A 143 GLU A 152 -1 N ALA A 147 O VAL A 372 SHEET 8 AA3 8 PHE A 448 SER A 457 -1 O LEU A 449 N PHE A 150 SHEET 1 AA4 5 SER A 180 PRO A 191 0 SHEET 2 AA4 5 TYR A 157 PHE A 175 -1 N TRP A 174 O GLN A 181 SHEET 3 AA4 5 HIS A 263 SER A 280 -1 O GLU A 274 N MET A 163 SHEET 4 AA4 5 PHE A 287 LEU A 289 -1 O VAL A 288 N ARG A 279 SHEET 5 AA4 5 PHE A 294 VAL A 295 -1 O VAL A 295 N PHE A 287 SHEET 1 AA5 7 LYS A 235 PRO A 236 0 SHEET 2 AA5 7 GLY A 246 HIS A 248 -1 O HIS A 248 N LYS A 235 SHEET 3 AA5 7 HIS A 263 SER A 280 -1 O VAL A 273 N TRP A 247 SHEET 4 AA5 7 TYR A 157 PHE A 175 -1 N MET A 163 O GLU A 274 SHEET 5 AA5 7 THR A 351 ASP A 355 -1 O THR A 351 N TYR A 164 SHEET 6 AA5 7 THR A 340 THR A 346 -1 N ASN A 343 O TRP A 354 SHEET 7 AA5 7 PHE A 319 PHE A 325 -1 N PHE A 325 O THR A 340 SHEET 1 AA6 2 VAL A 206 ARG A 208 0 SHEET 2 AA6 2 ASP A 231 GLU A 233 -1 O MET A 232 N CYS A 207 SHEET 1 AA7 2 THR A 210 ARG A 215 0 SHEET 2 AA7 2 MET A 218 PHE A 223 -1 O THR A 220 N TYR A 213 SHEET 1 AA8 2 THR A 595 TYR A 597 0 SHEET 2 AA8 2 LEU A 630 PRO A 632 -1 O GLU A 631 N CYS A 596 SHEET 1 AA9 3 ARG A 638 PHE A 643 0 SHEET 2 AA9 3 GLY A 646 GLU A 651 -1 O GLY A 646 N PHE A 643 SHEET 3 AA9 3 ALA A 654 SER A 660 -1 O ALA A 654 N GLU A 651 SHEET 1 AB1 4 THR A 665 VAL A 667 0 SHEET 2 AB1 4 THR B 123 PHE B 127 1 O GLN B 126 N VAL A 667 SHEET 3 AB1 4 VAL B 567 THR B 572 -1 O MET B 568 N VAL B 125 SHEET 4 AB1 4 VAL B 559 LEU B 564 -1 N ARG B 562 O ALA B 569 SHEET 1 AB2 2 PHE B 113 VAL B 115 0 SHEET 2 AB2 2 VAL B 574 VAL B 576 -1 O VAL B 574 N VAL B 115 SHEET 1 AB3 4 MET B 366 VAL B 372 0 SHEET 2 AB3 4 GLY B 145 GLU B 152 -1 N ALA B 147 O VAL B 372 SHEET 3 AB3 4 PHE B 448 SER B 457 -1 O LEU B 449 N PHE B 150 SHEET 4 AB3 4 HIS B 433 LYS B 435 -1 N ILE B 434 O LEU B 456 SHEET 1 AB4 4 MET B 366 VAL B 372 0 SHEET 2 AB4 4 GLY B 145 GLU B 152 -1 N ALA B 147 O VAL B 372 SHEET 3 AB4 4 PHE B 448 SER B 457 -1 O LEU B 449 N PHE B 150 SHEET 4 AB4 4 GLN B 440 ALA B 444 -1 N ALA B 444 O PHE B 448 SHEET 1 AB5 5 SER B 180 PRO B 191 0 SHEET 2 AB5 5 TYR B 157 PHE B 175 -1 N TRP B 174 O GLN B 181 SHEET 3 AB5 5 HIS B 263 SER B 280 -1 O GLU B 274 N MET B 163 SHEET 4 AB5 5 PHE B 287 LEU B 289 -1 O VAL B 288 N ARG B 279 SHEET 5 AB5 5 PHE B 294 VAL B 295 -1 O VAL B 295 N PHE B 287 SHEET 1 AB6 7 LYS B 235 PRO B 236 0 SHEET 2 AB6 7 GLY B 246 HIS B 248 -1 O HIS B 248 N LYS B 235 SHEET 3 AB6 7 HIS B 263 SER B 280 -1 O VAL B 273 N TRP B 247 SHEET 4 AB6 7 TYR B 157 PHE B 175 -1 N MET B 163 O GLU B 274 SHEET 5 AB6 7 THR B 351 ASP B 355 -1 O THR B 351 N TYR B 164 SHEET 6 AB6 7 THR B 340 THR B 346 -1 N LEU B 345 O VAL B 352 SHEET 7 AB6 7 PHE B 319 PHE B 325 -1 N LYS B 320 O LEU B 344 SHEET 1 AB7 2 VAL B 206 ARG B 208 0 SHEET 2 AB7 2 ASP B 231 GLU B 233 -1 O MET B 232 N CYS B 207 SHEET 1 AB8 2 THR B 210 ARG B 215 0 SHEET 2 AB8 2 MET B 218 PHE B 223 -1 O THR B 220 N TYR B 213 SHEET 1 AB9 3 MET B 375 TYR B 380 0 SHEET 2 AB9 3 SER B 383 SER B 388 -1 O SER B 387 N LEU B 376 SHEET 3 AB9 3 THR B 393 ASN B 398 -1 O PHE B 395 N PHE B 386 SHEET 1 AC1 3 VAL B 581 VAL B 583 0 SHEET 2 AC1 3 LEU B 601 PHE B 604 -1 O SER B 603 N ILE B 582 SHEET 3 AC1 3 ILE B 613 GLN B 616 -1 O ILE B 613 N PHE B 604 SHEET 1 AC2 2 THR B 595 TYR B 597 0 SHEET 2 AC2 2 LEU B 630 PRO B 632 -1 O GLU B 631 N CYS B 596 SHEET 1 AC3 3 ARG B 638 PHE B 643 0 SHEET 2 AC3 3 GLY B 646 GLU B 651 -1 O GLY B 646 N PHE B 643 SHEET 3 AC3 3 TYR B 655 LEU B 659 -1 O HIS B 657 N TYR B 649 SHEET 1 AC4 4 THR B 665 VAL B 667 0 SHEET 2 AC4 4 VAL C 124 PHE C 127 1 O GLN C 126 N VAL B 667 SHEET 3 AC4 4 VAL C 567 THR C 572 -1 O MET C 568 N VAL C 125 SHEET 4 AC4 4 VAL C 559 LEU C 564 -1 N ARG C 562 O ALA C 569 SHEET 1 AC5 2 PHE C 113 VAL C 115 0 SHEET 2 AC5 2 VAL C 574 VAL C 576 -1 O VAL C 574 N VAL C 115 SHEET 1 AC6 4 MET C 366 VAL C 372 0 SHEET 2 AC6 4 GLY C 145 GLU C 152 -1 N ALA C 147 O VAL C 372 SHEET 3 AC6 4 PHE C 448 SER C 457 -1 O LEU C 449 N PHE C 150 SHEET 4 AC6 4 HIS C 433 LYS C 435 -1 N ILE C 434 O LEU C 456 SHEET 1 AC7 4 MET C 366 VAL C 372 0 SHEET 2 AC7 4 GLY C 145 GLU C 152 -1 N ALA C 147 O VAL C 372 SHEET 3 AC7 4 PHE C 448 SER C 457 -1 O LEU C 449 N PHE C 150 SHEET 4 AC7 4 GLN C 440 ALA C 444 -1 N ALA C 444 O PHE C 448 SHEET 1 AC8 5 SER C 180 PRO C 191 0 SHEET 2 AC8 5 TYR C 157 PHE C 175 -1 N TRP C 174 O GLN C 181 SHEET 3 AC8 5 HIS C 263 SER C 280 -1 O GLU C 274 N MET C 163 SHEET 4 AC8 5 PHE C 287 LEU C 289 -1 O VAL C 288 N ARG C 279 SHEET 5 AC8 5 PHE C 294 VAL C 295 -1 O VAL C 295 N PHE C 287 SHEET 1 AC9 7 LYS C 235 PRO C 236 0 SHEET 2 AC9 7 GLY C 246 HIS C 248 -1 O HIS C 248 N LYS C 235 SHEET 3 AC9 7 HIS C 263 SER C 280 -1 O VAL C 273 N TRP C 247 SHEET 4 AC9 7 TYR C 157 PHE C 175 -1 N MET C 163 O GLU C 274 SHEET 5 AC9 7 THR C 351 ASP C 355 -1 O THR C 351 N TYR C 164 SHEET 6 AC9 7 THR C 340 THR C 346 -1 N LEU C 345 O VAL C 352 SHEET 7 AC9 7 PHE C 319 PHE C 325 -1 N LYS C 320 O LEU C 344 SHEET 1 AD1 2 VAL C 206 ARG C 208 0 SHEET 2 AD1 2 ASP C 231 GLU C 233 -1 O MET C 232 N CYS C 207 SHEET 1 AD2 2 THR C 210 ARG C 215 0 SHEET 2 AD2 2 MET C 218 PHE C 223 -1 O THR C 220 N TYR C 213 SHEET 1 AD3 3 MET C 375 TYR C 380 0 SHEET 2 AD3 3 SER C 383 SER C 388 -1 O SER C 387 N LEU C 376 SHEET 3 AD3 3 THR C 393 ASN C 398 -1 O PHE C 395 N PHE C 386 SHEET 1 AD4 4 VAL C 581 VAL C 583 0 SHEET 2 AD4 4 LEU C 601 ARG C 605 -1 O SER C 603 N ILE C 582 SHEET 3 AD4 4 LEU C 612 GLY C 618 -1 O ILE C 613 N PHE C 604 SHEET 4 AD4 4 GLU C 622 ARG C 624 -1 O GLU C 622 N GLY C 618 SHEET 1 AD5 2 THR C 595 TYR C 597 0 SHEET 2 AD5 2 LEU C 630 PRO C 632 -1 O GLU C 631 N CYS C 596 SHEET 1 AD6 3 ARG C 638 PHE C 643 0 SHEET 2 AD6 3 GLY C 646 GLU C 651 -1 O GLY C 646 N PHE C 643 SHEET 3 AD6 3 ALA C 654 LEU C 659 -1 O LEU C 659 N TYR C 647 SHEET 1 AD7 4 VAL D 2 SER D 7 0 SHEET 2 AD7 4 SER D 17 GLY D 26 -1 O SER D 25 N GLN D 3 SHEET 3 AD7 4 SER D 80 ASN D 86 -1 O MET D 85 N LEU D 18 SHEET 4 AD7 4 PHE D 70 ARG D 74 -1 N THR D 71 O GLN D 84 SHEET 1 AD8 6 GLY D 10 VAL D 12 0 SHEET 2 AD8 6 THR D 119 VAL D 123 1 O THR D 122 N GLY D 10 SHEET 3 AD8 6 ALA D 94 ASP D 101 -1 N TYR D 96 O THR D 119 SHEET 4 AD8 6 ARG D 33 GLN D 39 -1 N ARG D 33 O ASP D 101 SHEET 5 AD8 6 ARG D 45 SER D 52 -1 O HIS D 51 N MET D 34 SHEET 6 AD8 6 ARG D 59 TYR D 62 -1 O ARG D 59 N SER D 52 SHEET 1 AD9 4 GLY D 10 VAL D 12 0 SHEET 2 AD9 4 THR D 119 VAL D 123 1 O THR D 122 N GLY D 10 SHEET 3 AD9 4 ALA D 94 ASP D 101 -1 N TYR D 96 O THR D 119 SHEET 4 AD9 4 TYR D 114 TRP D 115 -1 O TYR D 114 N PHE D 100 SHEET 1 AE1 4 VAL E 2 SER E 7 0 SHEET 2 AE1 4 SER E 17 GLY E 26 -1 O SER E 25 N GLN E 3 SHEET 3 AE1 4 SER E 80 ASN E 86 -1 O MET E 85 N LEU E 18 SHEET 4 AE1 4 PHE E 70 ARG E 74 -1 N THR E 71 O GLN E 84 SHEET 1 AE2 6 GLY E 10 VAL E 12 0 SHEET 2 AE2 6 THR E 119 VAL E 123 1 O THR E 122 N GLY E 10 SHEET 3 AE2 6 ALA E 94 ASP E 101 -1 N TYR E 96 O THR E 119 SHEET 4 AE2 6 ARG E 33 GLN E 39 -1 N ARG E 33 O ASP E 101 SHEET 5 AE2 6 ARG E 45 SER E 52 -1 O HIS E 51 N MET E 34 SHEET 6 AE2 6 ARG E 59 TYR E 62 -1 O ARG E 59 N SER E 52 SHEET 1 AE3 4 GLY E 10 VAL E 12 0 SHEET 2 AE3 4 THR E 119 VAL E 123 1 O THR E 122 N GLY E 10 SHEET 3 AE3 4 ALA E 94 ASP E 101 -1 N TYR E 96 O THR E 119 SHEET 4 AE3 4 TYR E 114 TRP E 115 -1 O TYR E 114 N PHE E 100 SHEET 1 AE4 4 VAL F 2 SER F 7 0 SHEET 2 AE4 4 SER F 17 GLY F 26 -1 O SER F 25 N GLN F 3 SHEET 3 AE4 4 SER F 80 ASN F 86 -1 O MET F 85 N LEU F 18 SHEET 4 AE4 4 PHE F 70 ARG F 74 -1 N THR F 71 O GLN F 84 SHEET 1 AE5 6 GLY F 10 VAL F 12 0 SHEET 2 AE5 6 THR F 119 VAL F 123 1 O THR F 122 N GLY F 10 SHEET 3 AE5 6 ALA F 94 ASP F 101 -1 N TYR F 96 O THR F 119 SHEET 4 AE5 6 ARG F 33 GLN F 39 -1 N ARG F 33 O ASP F 101 SHEET 5 AE5 6 ARG F 45 SER F 52 -1 O HIS F 51 N MET F 34 SHEET 6 AE5 6 ARG F 59 TYR F 62 -1 O ARG F 59 N SER F 52 SHEET 1 AE6 4 GLY F 10 VAL F 12 0 SHEET 2 AE6 4 THR F 119 VAL F 123 1 O THR F 122 N GLY F 10 SHEET 3 AE6 4 ALA F 94 ASP F 101 -1 N TYR F 96 O THR F 119 SHEET 4 AE6 4 TYR F 114 TRP F 115 -1 O TYR F 114 N PHE F 100 SSBOND 1 CYS A 116 CYS A 573 1555 1555 2.03 SSBOND 2 CYS A 133 CYS A 529 1555 1555 2.03 SSBOND 3 CYS A 207 CYS A 271 1555 1555 2.04 SSBOND 4 CYS A 364 CYS A 412 1555 1555 2.02 SSBOND 5 CYS A 596 CYS A 633 1555 1555 2.04 SSBOND 6 CYS B 116 CYS B 573 1555 1555 2.03 SSBOND 7 CYS B 133 CYS B 529 1555 1555 2.03 SSBOND 8 CYS B 207 CYS B 271 1555 1555 2.04 SSBOND 9 CYS B 364 CYS B 412 1555 1555 2.03 SSBOND 10 CYS B 596 CYS B 633 1555 1555 2.04 SSBOND 11 CYS C 116 CYS C 573 1555 1555 2.03 SSBOND 12 CYS C 133 CYS C 529 1555 1555 2.03 SSBOND 13 CYS C 207 CYS C 271 1555 1555 2.04 SSBOND 14 CYS C 364 CYS C 412 1555 1555 2.02 SSBOND 15 CYS C 596 CYS C 633 1555 1555 2.03 SSBOND 16 CYS D 22 CYS D 98 1555 1555 2.03 SSBOND 17 CYS E 22 CYS E 98 1555 1555 2.03 SSBOND 18 CYS F 22 CYS F 98 1555 1555 2.03 CISPEP 1 TYR A 282 PRO A 283 0 7.67 CISPEP 2 TYR B 282 PRO B 283 0 5.33 CISPEP 3 TYR C 282 PRO C 283 0 5.57 CISPEP 4 ASN D 56 PRO D 57 0 6.27 CISPEP 5 ASN E 56 PRO E 57 0 6.96 CISPEP 6 ASN F 56 PRO F 57 0 7.53 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000