HEADER IMMUNE SYSTEM 04-FEB-25 9N5O TITLE ENDOGENOUS PFS230D7-8 IN COMPLEX WITH 18F25 COMPND MOL_ID: 1; COMPND 2 MOLECULE: GAMETOCYTE SURFACE PROTEIN P230; COMPND 3 CHAIN: B; COMPND 4 MOL_ID: 2; COMPND 5 MOLECULE: 18F25 HEAVY CHAIN; COMPND 6 CHAIN: H; COMPND 7 ENGINEERED: YES; COMPND 8 MOL_ID: 3; COMPND 9 MOLECULE: 18F25 KAPPA CHAIN; COMPND 10 CHAIN: L; COMPND 11 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: PLASMODIUM FALCIPARUM 3D7; SOURCE 3 ORGANISM_TAXID: 36329; SOURCE 4 MOL_ID: 2; SOURCE 5 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 6 ORGANISM_TAXID: 10090; SOURCE 7 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 9 MOL_ID: 3; SOURCE 10 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 11 ORGANISM_TAXID: 10090; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS 6-CYS, ANTIBODY, IMMUNE SYSTEM EXPDTA ELECTRON MICROSCOPY AUTHOR J.J.JACKMAN,R.YOO,D.IVANOCHKO,S.HAILEMARIAM,E.BEKKERING,J.P.JULIEN REVDAT 1 15-OCT-25 9N5O 0 JRNL AUTH E.T.BEKKERING,R.YOO,S.HAILEMARIAM,F.HEIDE,D.IVANOCHKO, JRNL AUTH 2 M.JACKMAN,N.I.PROELLOCHS,R.STOTER,G.J.VAN GEMERT,A.MAEDA, JRNL AUTH 3 T.YUGUCHI,O.T.WANDERS,R.C.VAN DAALEN,M.R.INKLAAR, JRNL AUTH 4 C.M.ANDRADE,P.W.T.C.JANSEN,M.VERMEULEN,T.BOUSEMA, JRNL AUTH 5 E.TAKASHIMA,J.L.RUBINSTEIN,T.W.A.KOOIJ,M.M.JORE,J.P.JULIEN JRNL TITL STRUCTURE OF ENDOGENOUS PFS230:PFS48/45 IN COMPLEX WITH JRNL TITL 2 POTENT MALARIA TRANSMISSION-BLOCKING ANTIBODIES. JRNL REF IMMUNITY 2025 JRNL REFN ISSN 1074-7613 REMARK 2 REMARK 2 RESOLUTION. 4.32 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, EPU, CRYOSPARC, UCSF REMARK 3 CHIMERAX, CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : 9N6U REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.320 REMARK 3 NUMBER OF PARTICLES : 137749 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9N5O COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 06-FEB-25. REMARK 100 THE DEPOSITION ID IS D_1000292590. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : ENDOGENOUS PFS230D7-8 IN REMARK 245 COMPLEX WITH 18F25 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.80 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : THE LEICA AUTOMATIC PLUNGE REMARK 245 FREEZER EM GP2 WAS USED FOR REMARK 245 FREEZING. REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : OTHER REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2300.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5200.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 130000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, H, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET B 1 REMARK 465 LYS B 2 REMARK 465 LYS B 3 REMARK 465 ILE B 4 REMARK 465 ILE B 5 REMARK 465 THR B 6 REMARK 465 LEU B 7 REMARK 465 LYS B 8 REMARK 465 ASN B 9 REMARK 465 LEU B 10 REMARK 465 PHE B 11 REMARK 465 LEU B 12 REMARK 465 ILE B 13 REMARK 465 ILE B 14 REMARK 465 LEU B 15 REMARK 465 VAL B 16 REMARK 465 TYR B 17 REMARK 465 ILE B 18 REMARK 465 PHE B 19 REMARK 465 SER B 20 REMARK 465 GLU B 21 REMARK 465 LYS B 22 REMARK 465 LYS B 23 REMARK 465 ASP B 24 REMARK 465 LEU B 25 REMARK 465 ARG B 26 REMARK 465 CYS B 27 REMARK 465 ASN B 28 REMARK 465 VAL B 29 REMARK 465 ILE B 30 REMARK 465 LYS B 31 REMARK 465 GLY B 32 REMARK 465 ASN B 33 REMARK 465 ASN B 34 REMARK 465 ILE B 35 REMARK 465 LYS B 36 REMARK 465 ASP B 37 REMARK 465 ASP B 38 REMARK 465 GLU B 39 REMARK 465 ASP B 40 REMARK 465 LYS B 41 REMARK 465 ARG B 42 REMARK 465 PHE B 43 REMARK 465 HIS B 44 REMARK 465 LEU B 45 REMARK 465 PHE B 46 REMARK 465 TYR B 47 REMARK 465 TYR B 48 REMARK 465 SER B 49 REMARK 465 HIS B 50 REMARK 465 ASN B 51 REMARK 465 LEU B 52 REMARK 465 PHE B 53 REMARK 465 LYS B 54 REMARK 465 THR B 55 REMARK 465 PRO B 56 REMARK 465 GLU B 57 REMARK 465 THR B 58 REMARK 465 LYS B 59 REMARK 465 GLU B 60 REMARK 465 LYS B 61 REMARK 465 LYS B 62 REMARK 465 ASN B 63 REMARK 465 LYS B 64 REMARK 465 LYS B 65 REMARK 465 GLU B 66 REMARK 465 CYS B 67 REMARK 465 PHE B 68 REMARK 465 TYR B 69 REMARK 465 LYS B 70 REMARK 465 ASN B 71 REMARK 465 GLY B 72 REMARK 465 GLY B 73 REMARK 465 ILE B 74 REMARK 465 TYR B 75 REMARK 465 ASN B 76 REMARK 465 LEU B 77 REMARK 465 SER B 78 REMARK 465 LYS B 79 REMARK 465 GLU B 80 REMARK 465 ILE B 81 REMARK 465 ARG B 82 REMARK 465 MET B 83 REMARK 465 ARG B 84 REMARK 465 LYS B 85 REMARK 465 ASP B 86 REMARK 465 THR B 87 REMARK 465 SER B 88 REMARK 465 VAL B 89 REMARK 465 LYS B 90 REMARK 465 ILE B 91 REMARK 465 LYS B 92 REMARK 465 GLN B 93 REMARK 465 ARG B 94 REMARK 465 THR B 95 REMARK 465 CYS B 96 REMARK 465 PRO B 97 REMARK 465 PHE B 98 REMARK 465 HIS B 99 REMARK 465 LYS B 100 REMARK 465 GLU B 101 REMARK 465 GLY B 102 REMARK 465 SER B 103 REMARK 465 SER B 104 REMARK 465 PHE B 105 REMARK 465 GLU B 106 REMARK 465 MET B 107 REMARK 465 GLY B 108 REMARK 465 SER B 109 REMARK 465 LYS B 110 REMARK 465 ASN B 111 REMARK 465 ILE B 112 REMARK 465 THR B 113 REMARK 465 CYS B 114 REMARK 465 PHE B 115 REMARK 465 TYR B 116 REMARK 465 PRO B 117 REMARK 465 ILE B 118 REMARK 465 VAL B 119 REMARK 465 GLY B 120 REMARK 465 LYS B 121 REMARK 465 LYS B 122 REMARK 465 GLU B 123 REMARK 465 ARG B 124 REMARK 465 LYS B 125 REMARK 465 THR B 126 REMARK 465 LEU B 127 REMARK 465 ASP B 128 REMARK 465 THR B 129 REMARK 465 ILE B 130 REMARK 465 ILE B 131 REMARK 465 ILE B 132 REMARK 465 LYS B 133 REMARK 465 LYS B 134 REMARK 465 ASN B 135 REMARK 465 VAL B 136 REMARK 465 THR B 137 REMARK 465 ASN B 138 REMARK 465 ASP B 139 REMARK 465 HIS B 140 REMARK 465 VAL B 141 REMARK 465 VAL B 142 REMARK 465 SER B 143 REMARK 465 SER B 144 REMARK 465 ASP B 145 REMARK 465 MET B 146 REMARK 465 HIS B 147 REMARK 465 SER B 148 REMARK 465 ASN B 149 REMARK 465 VAL B 150 REMARK 465 GLN B 151 REMARK 465 GLU B 152 REMARK 465 LYS B 153 REMARK 465 ASN B 154 REMARK 465 MET B 155 REMARK 465 ILE B 156 REMARK 465 LEU B 157 REMARK 465 ILE B 158 REMARK 465 ARG B 159 REMARK 465 ASN B 160 REMARK 465 ILE B 161 REMARK 465 ASP B 162 REMARK 465 LYS B 163 REMARK 465 GLU B 164 REMARK 465 ASN B 165 REMARK 465 LYS B 166 REMARK 465 ASN B 167 REMARK 465 ASP B 168 REMARK 465 ILE B 169 REMARK 465 GLN B 170 REMARK 465 ASN B 171 REMARK 465 VAL B 172 REMARK 465 GLU B 173 REMARK 465 GLU B 174 REMARK 465 LYS B 175 REMARK 465 ILE B 176 REMARK 465 GLN B 177 REMARK 465 ARG B 178 REMARK 465 ASP B 179 REMARK 465 THR B 180 REMARK 465 TYR B 181 REMARK 465 GLU B 182 REMARK 465 ASN B 183 REMARK 465 LYS B 184 REMARK 465 ASP B 185 REMARK 465 TYR B 186 REMARK 465 GLU B 187 REMARK 465 SER B 188 REMARK 465 ASP B 189 REMARK 465 ASP B 190 REMARK 465 THR B 191 REMARK 465 LEU B 192 REMARK 465 ILE B 193 REMARK 465 GLU B 194 REMARK 465 TRP B 195 REMARK 465 PHE B 196 REMARK 465 ASP B 197 REMARK 465 ASP B 198 REMARK 465 ASN B 199 REMARK 465 THR B 200 REMARK 465 ASN B 201 REMARK 465 GLU B 202 REMARK 465 GLU B 203 REMARK 465 ASN B 204 REMARK 465 PHE B 205 REMARK 465 LEU B 206 REMARK 465 LEU B 207 REMARK 465 THR B 208 REMARK 465 PHE B 209 REMARK 465 LEU B 210 REMARK 465 LYS B 211 REMARK 465 ARG B 212 REMARK 465 CYS B 213 REMARK 465 LEU B 214 REMARK 465 MET B 215 REMARK 465 LYS B 216 REMARK 465 ILE B 217 REMARK 465 PHE B 218 REMARK 465 SER B 219 REMARK 465 SER B 220 REMARK 465 PRO B 221 REMARK 465 LYS B 222 REMARK 465 ARG B 223 REMARK 465 LYS B 224 REMARK 465 LYS B 225 REMARK 465 THR B 226 REMARK 465 VAL B 227 REMARK 465 VAL B 228 REMARK 465 GLN B 229 REMARK 465 LYS B 230 REMARK 465 LYS B 231 REMARK 465 HIS B 232 REMARK 465 LYS B 233 REMARK 465 SER B 234 REMARK 465 ASN B 235 REMARK 465 PHE B 236 REMARK 465 PHE B 237 REMARK 465 ILE B 238 REMARK 465 ASN B 239 REMARK 465 SER B 240 REMARK 465 SER B 241 REMARK 465 LEU B 242 REMARK 465 LYS B 243 REMARK 465 TYR B 244 REMARK 465 ILE B 245 REMARK 465 TYR B 246 REMARK 465 MET B 247 REMARK 465 TYR B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 PRO B 251 REMARK 465 SER B 252 REMARK 465 ASP B 253 REMARK 465 SER B 254 REMARK 465 PHE B 255 REMARK 465 ASN B 256 REMARK 465 LEU B 257 REMARK 465 VAL B 258 REMARK 465 ARG B 259 REMARK 465 ARG B 260 REMARK 465 ASN B 261 REMARK 465 ARG B 262 REMARK 465 ASN B 263 REMARK 465 LEU B 264 REMARK 465 ASP B 265 REMARK 465 GLU B 266 REMARK 465 GLU B 267 REMARK 465 ASP B 268 REMARK 465 MET B 269 REMARK 465 SER B 270 REMARK 465 PRO B 271 REMARK 465 ARG B 272 REMARK 465 ASP B 273 REMARK 465 ASN B 274 REMARK 465 PHE B 275 REMARK 465 VAL B 276 REMARK 465 ILE B 277 REMARK 465 ASP B 278 REMARK 465 ASP B 279 REMARK 465 GLU B 280 REMARK 465 GLU B 281 REMARK 465 GLU B 282 REMARK 465 GLU B 283 REMARK 465 GLU B 284 REMARK 465 GLU B 285 REMARK 465 GLU B 286 REMARK 465 GLU B 287 REMARK 465 GLU B 288 REMARK 465 GLU B 289 REMARK 465 GLU B 290 REMARK 465 GLU B 291 REMARK 465 GLU B 292 REMARK 465 GLU B 293 REMARK 465 GLU B 294 REMARK 465 GLU B 295 REMARK 465 GLU B 296 REMARK 465 GLU B 297 REMARK 465 GLU B 298 REMARK 465 GLU B 299 REMARK 465 GLU B 300 REMARK 465 GLU B 301 REMARK 465 GLU B 302 REMARK 465 GLU B 303 REMARK 465 GLU B 304 REMARK 465 TYR B 305 REMARK 465 ASP B 306 REMARK 465 ASP B 307 REMARK 465 TYR B 308 REMARK 465 VAL B 309 REMARK 465 TYR B 310 REMARK 465 GLU B 311 REMARK 465 GLU B 312 REMARK 465 SER B 313 REMARK 465 GLY B 314 REMARK 465 ASP B 315 REMARK 465 GLU B 316 REMARK 465 THR B 317 REMARK 465 GLU B 318 REMARK 465 GLU B 319 REMARK 465 GLN B 320 REMARK 465 LEU B 321 REMARK 465 GLN B 322 REMARK 465 GLU B 323 REMARK 465 GLU B 324 REMARK 465 HIS B 325 REMARK 465 GLN B 326 REMARK 465 GLU B 327 REMARK 465 GLU B 328 REMARK 465 VAL B 329 REMARK 465 GLY B 330 REMARK 465 ALA B 331 REMARK 465 GLU B 332 REMARK 465 SER B 333 REMARK 465 SER B 334 REMARK 465 GLU B 335 REMARK 465 GLU B 336 REMARK 465 SER B 337 REMARK 465 PHE B 338 REMARK 465 ASN B 339 REMARK 465 ASP B 340 REMARK 465 GLU B 341 REMARK 465 ASP B 342 REMARK 465 GLU B 343 REMARK 465 ASP B 344 REMARK 465 SER B 345 REMARK 465 VAL B 346 REMARK 465 GLU B 347 REMARK 465 ALA B 348 REMARK 465 ARG B 349 REMARK 465 ASP B 350 REMARK 465 GLY B 351 REMARK 465 ASP B 352 REMARK 465 MET B 353 REMARK 465 ILE B 354 REMARK 465 ARG B 355 REMARK 465 VAL B 356 REMARK 465 ASP B 357 REMARK 465 GLU B 358 REMARK 465 TYR B 359 REMARK 465 TYR B 360 REMARK 465 GLU B 361 REMARK 465 ASP B 362 REMARK 465 GLN B 363 REMARK 465 ASP B 364 REMARK 465 GLY B 365 REMARK 465 ASP B 366 REMARK 465 THR B 367 REMARK 465 TYR B 368 REMARK 465 ASP B 369 REMARK 465 SER B 370 REMARK 465 THR B 371 REMARK 465 ILE B 372 REMARK 465 LYS B 373 REMARK 465 ASN B 374 REMARK 465 GLU B 375 REMARK 465 ASP B 376 REMARK 465 VAL B 377 REMARK 465 ASP B 378 REMARK 465 GLU B 379 REMARK 465 GLU B 380 REMARK 465 VAL B 381 REMARK 465 GLY B 382 REMARK 465 GLU B 383 REMARK 465 GLU B 384 REMARK 465 VAL B 385 REMARK 465 GLY B 386 REMARK 465 GLU B 387 REMARK 465 GLU B 388 REMARK 465 VAL B 389 REMARK 465 GLY B 390 REMARK 465 GLU B 391 REMARK 465 GLU B 392 REMARK 465 VAL B 393 REMARK 465 GLY B 394 REMARK 465 GLU B 395 REMARK 465 GLU B 396 REMARK 465 VAL B 397 REMARK 465 GLY B 398 REMARK 465 GLU B 399 REMARK 465 GLU B 400 REMARK 465 VAL B 401 REMARK 465 GLY B 402 REMARK 465 GLU B 403 REMARK 465 GLU B 404 REMARK 465 VAL B 405 REMARK 465 GLY B 406 REMARK 465 GLU B 407 REMARK 465 GLU B 408 REMARK 465 VAL B 409 REMARK 465 GLY B 410 REMARK 465 GLU B 411 REMARK 465 GLU B 412 REMARK 465 VAL B 413 REMARK 465 GLY B 414 REMARK 465 GLU B 415 REMARK 465 GLU B 416 REMARK 465 GLU B 417 REMARK 465 GLY B 418 REMARK 465 GLU B 419 REMARK 465 GLU B 420 REMARK 465 VAL B 421 REMARK 465 GLY B 422 REMARK 465 GLU B 423 REMARK 465 GLY B 424 REMARK 465 VAL B 425 REMARK 465 GLY B 426 REMARK 465 GLU B 427 REMARK 465 GLU B 428 REMARK 465 VAL B 429 REMARK 465 GLY B 430 REMARK 465 GLU B 431 REMARK 465 GLU B 432 REMARK 465 GLU B 433 REMARK 465 GLY B 434 REMARK 465 GLU B 435 REMARK 465 GLU B 436 REMARK 465 VAL B 437 REMARK 465 GLY B 438 REMARK 465 GLU B 439 REMARK 465 GLU B 440 REMARK 465 GLU B 441 REMARK 465 GLY B 442 REMARK 465 GLU B 443 REMARK 465 TYR B 444 REMARK 465 VAL B 445 REMARK 465 ASP B 446 REMARK 465 GLU B 447 REMARK 465 LYS B 448 REMARK 465 GLU B 449 REMARK 465 ARG B 450 REMARK 465 GLN B 451 REMARK 465 GLY B 452 REMARK 465 GLU B 453 REMARK 465 ILE B 454 REMARK 465 TYR B 455 REMARK 465 PRO B 456 REMARK 465 PHE B 457 REMARK 465 GLY B 458 REMARK 465 ASP B 459 REMARK 465 GLU B 460 REMARK 465 GLU B 461 REMARK 465 GLU B 462 REMARK 465 LYS B 463 REMARK 465 ASP B 464 REMARK 465 GLU B 465 REMARK 465 GLY B 466 REMARK 465 GLY B 467 REMARK 465 GLU B 468 REMARK 465 SER B 469 REMARK 465 PHE B 470 REMARK 465 THR B 471 REMARK 465 TYR B 472 REMARK 465 GLU B 473 REMARK 465 LYS B 474 REMARK 465 SER B 475 REMARK 465 GLU B 476 REMARK 465 VAL B 477 REMARK 465 ASP B 478 REMARK 465 LYS B 479 REMARK 465 THR B 480 REMARK 465 ASP B 481 REMARK 465 LEU B 482 REMARK 465 PHE B 483 REMARK 465 LYS B 484 REMARK 465 PHE B 485 REMARK 465 ILE B 486 REMARK 465 GLU B 487 REMARK 465 GLY B 488 REMARK 465 GLY B 489 REMARK 465 GLU B 490 REMARK 465 GLY B 491 REMARK 465 ASP B 492 REMARK 465 ASP B 493 REMARK 465 VAL B 494 REMARK 465 TYR B 495 REMARK 465 LYS B 496 REMARK 465 VAL B 497 REMARK 465 ASP B 498 REMARK 465 GLY B 499 REMARK 465 SER B 500 REMARK 465 LYS B 501 REMARK 465 VAL B 502 REMARK 465 LEU B 503 REMARK 465 LEU B 504 REMARK 465 ASP B 505 REMARK 465 ASP B 506 REMARK 465 ASP B 507 REMARK 465 THR B 508 REMARK 465 ILE B 509 REMARK 465 SER B 510 REMARK 465 ARG B 511 REMARK 465 VAL B 512 REMARK 465 SER B 513 REMARK 465 LYS B 514 REMARK 465 LYS B 515 REMARK 465 HIS B 516 REMARK 465 THR B 517 REMARK 465 ALA B 518 REMARK 465 ARG B 519 REMARK 465 ASP B 520 REMARK 465 GLY B 521 REMARK 465 GLU B 522 REMARK 465 TYR B 523 REMARK 465 GLY B 524 REMARK 465 GLU B 525 REMARK 465 TYR B 526 REMARK 465 GLY B 527 REMARK 465 GLU B 528 REMARK 465 ALA B 529 REMARK 465 VAL B 530 REMARK 465 GLU B 531 REMARK 465 ASP B 532 REMARK 465 GLY B 533 REMARK 465 GLU B 534 REMARK 465 ASN B 535 REMARK 465 VAL B 536 REMARK 465 ILE B 537 REMARK 465 LYS B 538 REMARK 465 ILE B 539 REMARK 465 ILE B 540 REMARK 465 ARG B 541 REMARK 465 SER B 542 REMARK 465 VAL B 543 REMARK 465 LEU B 544 REMARK 465 GLN B 545 REMARK 465 SER B 546 REMARK 465 GLY B 547 REMARK 465 ALA B 548 REMARK 465 LEU B 549 REMARK 465 PRO B 550 REMARK 465 SER B 551 REMARK 465 VAL B 552 REMARK 465 GLY B 553 REMARK 465 VAL B 554 REMARK 465 ASP B 555 REMARK 465 GLU B 556 REMARK 465 LEU B 557 REMARK 465 ASP B 558 REMARK 465 LYS B 559 REMARK 465 ILE B 560 REMARK 465 ASP B 561 REMARK 465 LEU B 562 REMARK 465 SER B 563 REMARK 465 TYR B 564 REMARK 465 GLU B 565 REMARK 465 THR B 566 REMARK 465 THR B 567 REMARK 465 GLU B 568 REMARK 465 SER B 569 REMARK 465 GLY B 570 REMARK 465 ASP B 571 REMARK 465 THR B 572 REMARK 465 ALA B 573 REMARK 465 VAL B 574 REMARK 465 SER B 575 REMARK 465 GLU B 576 REMARK 465 ASP B 577 REMARK 465 SER B 578 REMARK 465 TYR B 579 REMARK 465 ASP B 580 REMARK 465 LYS B 581 REMARK 465 TYR B 582 REMARK 465 ALA B 583 REMARK 465 SER B 584 REMARK 465 ASN B 585 REMARK 465 ASN B 586 REMARK 465 THR B 587 REMARK 465 ASN B 588 REMARK 465 LYS B 589 REMARK 465 GLU B 590 REMARK 465 TYR B 591 REMARK 465 VAL B 592 REMARK 465 CYS B 593 REMARK 465 ASP B 594 REMARK 465 PHE B 595 REMARK 465 THR B 596 REMARK 465 ASP B 597 REMARK 465 GLN B 598 REMARK 465 LEU B 599 REMARK 465 LYS B 600 REMARK 465 PRO B 601 REMARK 465 THR B 602 REMARK 465 GLU B 603 REMARK 465 SER B 604 REMARK 465 GLY B 605 REMARK 465 PRO B 606 REMARK 465 LYS B 607 REMARK 465 VAL B 608 REMARK 465 LYS B 609 REMARK 465 LYS B 610 REMARK 465 CYS B 611 REMARK 465 GLU B 612 REMARK 465 VAL B 613 REMARK 465 LYS B 614 REMARK 465 VAL B 615 REMARK 465 ASN B 616 REMARK 465 GLU B 617 REMARK 465 PRO B 618 REMARK 465 LEU B 619 REMARK 465 ILE B 620 REMARK 465 LYS B 621 REMARK 465 VAL B 622 REMARK 465 LYS B 623 REMARK 465 ILE B 624 REMARK 465 ILE B 625 REMARK 465 CYS B 626 REMARK 465 PRO B 627 REMARK 465 LEU B 628 REMARK 465 LYS B 629 REMARK 465 GLY B 630 REMARK 465 SER B 631 REMARK 465 VAL B 632 REMARK 465 GLU B 633 REMARK 465 LYS B 634 REMARK 465 LEU B 635 REMARK 465 TYR B 636 REMARK 465 ASP B 637 REMARK 465 ASN B 638 REMARK 465 ILE B 639 REMARK 465 GLU B 640 REMARK 465 TYR B 641 REMARK 465 VAL B 642 REMARK 465 PRO B 643 REMARK 465 LYS B 644 REMARK 465 LYS B 645 REMARK 465 SER B 646 REMARK 465 PRO B 647 REMARK 465 TYR B 648 REMARK 465 VAL B 649 REMARK 465 VAL B 650 REMARK 465 LEU B 651 REMARK 465 THR B 652 REMARK 465 LYS B 653 REMARK 465 GLU B 654 REMARK 465 GLU B 655 REMARK 465 THR B 656 REMARK 465 LYS B 657 REMARK 465 LEU B 658 REMARK 465 LYS B 659 REMARK 465 GLU B 660 REMARK 465 LYS B 661 REMARK 465 LEU B 662 REMARK 465 LEU B 663 REMARK 465 SER B 664 REMARK 465 LYS B 665 REMARK 465 LEU B 666 REMARK 465 ILE B 667 REMARK 465 TYR B 668 REMARK 465 GLY B 669 REMARK 465 LEU B 670 REMARK 465 LEU B 671 REMARK 465 ILE B 672 REMARK 465 SER B 673 REMARK 465 PRO B 674 REMARK 465 THR B 675 REMARK 465 VAL B 676 REMARK 465 ASN B 677 REMARK 465 GLU B 678 REMARK 465 LYS B 679 REMARK 465 GLU B 680 REMARK 465 ASN B 681 REMARK 465 ASN B 682 REMARK 465 PHE B 683 REMARK 465 LYS B 684 REMARK 465 GLU B 685 REMARK 465 GLY B 686 REMARK 465 VAL B 687 REMARK 465 ILE B 688 REMARK 465 GLU B 689 REMARK 465 PHE B 690 REMARK 465 THR B 691 REMARK 465 LEU B 692 REMARK 465 PRO B 693 REMARK 465 PRO B 694 REMARK 465 VAL B 695 REMARK 465 VAL B 696 REMARK 465 HIS B 697 REMARK 465 LYS B 698 REMARK 465 ALA B 699 REMARK 465 THR B 700 REMARK 465 VAL B 701 REMARK 465 PHE B 702 REMARK 465 TYR B 703 REMARK 465 PHE B 704 REMARK 465 ILE B 705 REMARK 465 CYS B 706 REMARK 465 ASP B 707 REMARK 465 ASN B 708 REMARK 465 SER B 709 REMARK 465 LYS B 710 REMARK 465 THR B 711 REMARK 465 GLU B 712 REMARK 465 ASP B 713 REMARK 465 ASP B 714 REMARK 465 ASN B 715 REMARK 465 LYS B 716 REMARK 465 LYS B 717 REMARK 465 GLY B 718 REMARK 465 ASN B 719 REMARK 465 ARG B 720 REMARK 465 GLY B 721 REMARK 465 ILE B 722 REMARK 465 VAL B 723 REMARK 465 GLU B 724 REMARK 465 VAL B 725 REMARK 465 TYR B 726 REMARK 465 VAL B 727 REMARK 465 GLU B 728 REMARK 465 PRO B 729 REMARK 465 TYR B 730 REMARK 465 GLY B 731 REMARK 465 ASN B 732 REMARK 465 LYS B 733 REMARK 465 ILE B 734 REMARK 465 ASN B 735 REMARK 465 GLY B 736 REMARK 465 CYS B 737 REMARK 465 ALA B 738 REMARK 465 PHE B 739 REMARK 465 LEU B 740 REMARK 465 ASP B 741 REMARK 465 GLU B 742 REMARK 465 ASP B 743 REMARK 465 GLU B 744 REMARK 465 GLU B 745 REMARK 465 GLU B 746 REMARK 465 GLU B 747 REMARK 465 LYS B 748 REMARK 465 TYR B 749 REMARK 465 GLY B 750 REMARK 465 ASN B 751 REMARK 465 GLN B 752 REMARK 465 ILE B 753 REMARK 465 GLU B 754 REMARK 465 GLU B 755 REMARK 465 ASP B 756 REMARK 465 GLU B 757 REMARK 465 HIS B 758 REMARK 465 ASN B 759 REMARK 465 GLU B 760 REMARK 465 LYS B 761 REMARK 465 ILE B 762 REMARK 465 LYS B 763 REMARK 465 MET B 764 REMARK 465 LYS B 765 REMARK 465 THR B 766 REMARK 465 PHE B 767 REMARK 465 PHE B 768 REMARK 465 THR B 769 REMARK 465 GLN B 770 REMARK 465 ASN B 771 REMARK 465 ILE B 772 REMARK 465 TYR B 773 REMARK 465 LYS B 774 REMARK 465 LYS B 775 REMARK 465 ASN B 776 REMARK 465 ASN B 777 REMARK 465 ILE B 778 REMARK 465 TYR B 779 REMARK 465 PRO B 780 REMARK 465 CYS B 781 REMARK 465 TYR B 782 REMARK 465 MET B 783 REMARK 465 LYS B 784 REMARK 465 LEU B 785 REMARK 465 TYR B 786 REMARK 465 SER B 787 REMARK 465 GLY B 788 REMARK 465 ASP B 789 REMARK 465 ILE B 790 REMARK 465 GLY B 791 REMARK 465 GLY B 792 REMARK 465 ILE B 793 REMARK 465 LEU B 794 REMARK 465 PHE B 795 REMARK 465 PRO B 796 REMARK 465 LYS B 797 REMARK 465 ASN B 798 REMARK 465 ILE B 799 REMARK 465 LYS B 800 REMARK 465 SER B 801 REMARK 465 THR B 802 REMARK 465 THR B 803 REMARK 465 CYS B 804 REMARK 465 PHE B 805 REMARK 465 GLU B 806 REMARK 465 GLU B 807 REMARK 465 MET B 808 REMARK 465 ILE B 809 REMARK 465 PRO B 810 REMARK 465 TYR B 811 REMARK 465 ASN B 812 REMARK 465 LYS B 813 REMARK 465 GLU B 814 REMARK 465 ILE B 815 REMARK 465 LYS B 816 REMARK 465 TRP B 817 REMARK 465 ASN B 818 REMARK 465 LYS B 819 REMARK 465 GLU B 820 REMARK 465 ASN B 821 REMARK 465 LYS B 822 REMARK 465 SER B 823 REMARK 465 LEU B 824 REMARK 465 GLY B 825 REMARK 465 ASN B 826 REMARK 465 LEU B 827 REMARK 465 VAL B 828 REMARK 465 ASN B 829 REMARK 465 ASN B 830 REMARK 465 SER B 831 REMARK 465 VAL B 832 REMARK 465 VAL B 833 REMARK 465 TYR B 834 REMARK 465 ASN B 835 REMARK 465 LYS B 836 REMARK 465 GLU B 837 REMARK 465 MET B 838 REMARK 465 ASN B 839 REMARK 465 ALA B 840 REMARK 465 LYS B 841 REMARK 465 TYR B 842 REMARK 465 PHE B 843 REMARK 465 ASN B 844 REMARK 465 VAL B 845 REMARK 465 GLN B 846 REMARK 465 TYR B 847 REMARK 465 VAL B 848 REMARK 465 HIS B 849 REMARK 465 ILE B 850 REMARK 465 PRO B 851 REMARK 465 THR B 852 REMARK 465 SER B 853 REMARK 465 TYR B 854 REMARK 465 LYS B 855 REMARK 465 ASP B 856 REMARK 465 THR B 857 REMARK 465 LEU B 858 REMARK 465 ASN B 859 REMARK 465 LEU B 860 REMARK 465 PHE B 861 REMARK 465 CYS B 862 REMARK 465 SER B 863 REMARK 465 ILE B 864 REMARK 465 ILE B 865 REMARK 465 LEU B 866 REMARK 465 LYS B 867 REMARK 465 GLU B 868 REMARK 465 GLU B 869 REMARK 465 GLU B 870 REMARK 465 SER B 871 REMARK 465 ASN B 872 REMARK 465 LEU B 873 REMARK 465 ILE B 874 REMARK 465 SER B 875 REMARK 465 THR B 876 REMARK 465 SER B 877 REMARK 465 TYR B 878 REMARK 465 LEU B 879 REMARK 465 VAL B 880 REMARK 465 TYR B 881 REMARK 465 VAL B 882 REMARK 465 SER B 883 REMARK 465 ILE B 884 REMARK 465 ASN B 885 REMARK 465 GLU B 886 REMARK 465 GLU B 887 REMARK 465 LEU B 888 REMARK 465 ASN B 889 REMARK 465 PHE B 890 REMARK 465 SER B 891 REMARK 465 LEU B 892 REMARK 465 PHE B 893 REMARK 465 ASP B 894 REMARK 465 PHE B 895 REMARK 465 TYR B 896 REMARK 465 GLU B 897 REMARK 465 SER B 898 REMARK 465 PHE B 899 REMARK 465 VAL B 900 REMARK 465 PRO B 901 REMARK 465 ILE B 902 REMARK 465 LYS B 903 REMARK 465 LYS B 904 REMARK 465 THR B 905 REMARK 465 ILE B 906 REMARK 465 GLN B 907 REMARK 465 VAL B 908 REMARK 465 ALA B 909 REMARK 465 GLN B 910 REMARK 465 LYS B 911 REMARK 465 ASN B 912 REMARK 465 VAL B 913 REMARK 465 ASN B 914 REMARK 465 ASN B 915 REMARK 465 LYS B 916 REMARK 465 GLU B 917 REMARK 465 HIS B 918 REMARK 465 ASP B 919 REMARK 465 TYR B 920 REMARK 465 THR B 921 REMARK 465 CYS B 922 REMARK 465 ASP B 923 REMARK 465 PHE B 924 REMARK 465 THR B 925 REMARK 465 ASP B 926 REMARK 465 LYS B 927 REMARK 465 LEU B 928 REMARK 465 ASP B 929 REMARK 465 LYS B 930 REMARK 465 THR B 931 REMARK 465 VAL B 932 REMARK 465 PRO B 933 REMARK 465 SER B 934 REMARK 465 THR B 935 REMARK 465 ALA B 936 REMARK 465 ASN B 937 REMARK 465 GLY B 938 REMARK 465 LYS B 939 REMARK 465 LYS B 940 REMARK 465 LEU B 941 REMARK 465 PHE B 942 REMARK 465 ILE B 943 REMARK 465 CYS B 944 REMARK 465 ARG B 945 REMARK 465 LYS B 946 REMARK 465 HIS B 947 REMARK 465 LEU B 948 REMARK 465 LYS B 949 REMARK 465 GLU B 950 REMARK 465 PHE B 951 REMARK 465 ASP B 952 REMARK 465 THR B 953 REMARK 465 PHE B 954 REMARK 465 THR B 955 REMARK 465 LEU B 956 REMARK 465 LYS B 957 REMARK 465 CYS B 958 REMARK 465 ASN B 959 REMARK 465 VAL B 960 REMARK 465 ASN B 961 REMARK 465 LYS B 962 REMARK 465 THR B 963 REMARK 465 GLN B 964 REMARK 465 TYR B 965 REMARK 465 PRO B 966 REMARK 465 ASN B 967 REMARK 465 ILE B 968 REMARK 465 GLU B 969 REMARK 465 ILE B 970 REMARK 465 PHE B 971 REMARK 465 PRO B 972 REMARK 465 LYS B 973 REMARK 465 THR B 974 REMARK 465 LEU B 975 REMARK 465 LYS B 976 REMARK 465 ASP B 977 REMARK 465 LYS B 978 REMARK 465 LYS B 979 REMARK 465 GLU B 980 REMARK 465 VAL B 981 REMARK 465 LEU B 982 REMARK 465 LYS B 983 REMARK 465 LEU B 984 REMARK 465 ASP B 985 REMARK 465 LEU B 986 REMARK 465 ASP B 987 REMARK 465 ILE B 988 REMARK 465 GLN B 989 REMARK 465 TYR B 990 REMARK 465 GLN B 991 REMARK 465 MET B 992 REMARK 465 PHE B 993 REMARK 465 SER B 994 REMARK 465 LYS B 995 REMARK 465 PHE B 996 REMARK 465 PHE B 997 REMARK 465 LYS B 998 REMARK 465 PHE B 999 REMARK 465 ASN B 1000 REMARK 465 THR B 1001 REMARK 465 GLN B 1002 REMARK 465 ASN B 1003 REMARK 465 ALA B 1004 REMARK 465 LYS B 1005 REMARK 465 TYR B 1006 REMARK 465 LEU B 1007 REMARK 465 ASN B 1008 REMARK 465 LEU B 1009 REMARK 465 TYR B 1010 REMARK 465 PRO B 1011 REMARK 465 TYR B 1012 REMARK 465 TYR B 1013 REMARK 465 LEU B 1014 REMARK 465 ILE B 1015 REMARK 465 PHE B 1016 REMARK 465 PRO B 1017 REMARK 465 PHE B 1018 REMARK 465 ASN B 1019 REMARK 465 HIS B 1020 REMARK 465 ILE B 1021 REMARK 465 GLY B 1022 REMARK 465 LYS B 1023 REMARK 465 LYS B 1024 REMARK 465 GLU B 1025 REMARK 465 LEU B 1026 REMARK 465 LYS B 1027 REMARK 465 ASN B 1028 REMARK 465 ASN B 1029 REMARK 465 PRO B 1030 REMARK 465 THR B 1031 REMARK 465 TYR B 1032 REMARK 465 LYS B 1033 REMARK 465 ASN B 1034 REMARK 465 HIS B 1035 REMARK 465 LYS B 1036 REMARK 465 ASP B 1037 REMARK 465 VAL B 1038 REMARK 465 LYS B 1039 REMARK 465 TYR B 1040 REMARK 465 PHE B 1041 REMARK 465 GLU B 1042 REMARK 465 GLN B 1043 REMARK 465 SER B 1044 REMARK 465 SER B 1045 REMARK 465 VAL B 1046 REMARK 465 LEU B 1047 REMARK 465 SER B 1048 REMARK 465 PRO B 1049 REMARK 465 LEU B 1050 REMARK 465 SER B 1051 REMARK 465 SER B 1052 REMARK 465 ALA B 1053 REMARK 465 ASP B 1054 REMARK 465 SER B 1055 REMARK 465 LEU B 1056 REMARK 465 GLY B 1057 REMARK 465 LYS B 1058 REMARK 465 LEU B 1059 REMARK 465 LEU B 1060 REMARK 465 ASN B 1061 REMARK 465 PHE B 1062 REMARK 465 LEU B 1063 REMARK 465 ASP B 1064 REMARK 465 THR B 1065 REMARK 465 GLN B 1066 REMARK 465 GLU B 1067 REMARK 465 THR B 1068 REMARK 465 VAL B 1069 REMARK 465 CYS B 1070 REMARK 465 LEU B 1071 REMARK 465 THR B 1072 REMARK 465 GLU B 1073 REMARK 465 LYS B 1074 REMARK 465 ILE B 1075 REMARK 465 ARG B 1076 REMARK 465 TYR B 1077 REMARK 465 LEU B 1078 REMARK 465 ASN B 1079 REMARK 465 LEU B 1080 REMARK 465 SER B 1081 REMARK 465 ILE B 1082 REMARK 465 ASN B 1083 REMARK 465 GLU B 1084 REMARK 465 LEU B 1085 REMARK 465 GLY B 1086 REMARK 465 SER B 1087 REMARK 465 ASP B 1088 REMARK 465 ASN B 1089 REMARK 465 ASN B 1090 REMARK 465 THR B 1091 REMARK 465 PHE B 1092 REMARK 465 SER B 1093 REMARK 465 VAL B 1094 REMARK 465 THR B 1095 REMARK 465 PHE B 1096 REMARK 465 GLN B 1097 REMARK 465 VAL B 1098 REMARK 465 PRO B 1099 REMARK 465 PRO B 1100 REMARK 465 TYR B 1101 REMARK 465 ILE B 1102 REMARK 465 ASP B 1103 REMARK 465 ILE B 1104 REMARK 465 LYS B 1105 REMARK 465 GLU B 1106 REMARK 465 PRO B 1107 REMARK 465 PHE B 1108 REMARK 465 TYR B 1109 REMARK 465 PHE B 1110 REMARK 465 MET B 1111 REMARK 465 PHE B 1112 REMARK 465 GLY B 1113 REMARK 465 CYS B 1114 REMARK 465 ASN B 1115 REMARK 465 ASN B 1116 REMARK 465 ASN B 1117 REMARK 465 LYS B 1118 REMARK 465 GLY B 1119 REMARK 465 GLU B 1120 REMARK 465 GLY B 1121 REMARK 465 ASN B 1122 REMARK 465 ILE B 1123 REMARK 465 GLY B 1124 REMARK 465 ILE B 1125 REMARK 465 VAL B 1126 REMARK 465 GLU B 1127 REMARK 465 LEU B 1128 REMARK 465 LEU B 1129 REMARK 465 ILE B 1130 REMARK 465 SER B 1131 REMARK 465 LYS B 1132 REMARK 465 GLN B 1133 REMARK 465 GLU B 1134 REMARK 465 GLU B 1135 REMARK 465 LYS B 1136 REMARK 465 ILE B 1137 REMARK 465 LYS B 1138 REMARK 465 GLY B 1139 REMARK 465 CYS B 1140 REMARK 465 ASN B 1141 REMARK 465 PHE B 1142 REMARK 465 HIS B 1143 REMARK 465 GLU B 1144 REMARK 465 SER B 1145 REMARK 465 LYS B 1146 REMARK 465 LEU B 1147 REMARK 465 ASP B 1148 REMARK 465 TYR B 1149 REMARK 465 PHE B 1150 REMARK 465 ASN B 1151 REMARK 465 GLU B 1152 REMARK 465 ASN B 1153 REMARK 465 ILE B 1154 REMARK 465 SER B 1155 REMARK 465 SER B 1156 REMARK 465 ASP B 1157 REMARK 465 THR B 1158 REMARK 465 HIS B 1159 REMARK 465 GLU B 1160 REMARK 465 CYS B 1161 REMARK 465 THR B 1162 REMARK 465 LEU B 1163 REMARK 465 HIS B 1164 REMARK 465 ALA B 1165 REMARK 465 TYR B 1166 REMARK 465 GLU B 1167 REMARK 465 ASN B 1168 REMARK 465 ASP B 1169 REMARK 465 ILE B 1170 REMARK 465 ILE B 1171 REMARK 465 GLY B 1172 REMARK 465 PHE B 1173 REMARK 465 ASN B 1174 REMARK 465 CYS B 1175 REMARK 465 LEU B 1176 REMARK 465 GLU B 1177 REMARK 465 THR B 1178 REMARK 465 THR B 1179 REMARK 465 HIS B 1180 REMARK 465 PRO B 1181 REMARK 465 ASN B 1182 REMARK 465 GLU B 1183 REMARK 465 VAL B 1184 REMARK 465 GLU B 1185 REMARK 465 VAL B 1186 REMARK 465 GLU B 1187 REMARK 465 VAL B 1188 REMARK 465 GLU B 1189 REMARK 465 ASP B 1190 REMARK 465 ALA B 1191 REMARK 465 GLU B 1192 REMARK 465 ILE B 1193 REMARK 465 TYR B 1194 REMARK 465 LEU B 1195 REMARK 465 GLN B 1196 REMARK 465 PRO B 1197 REMARK 465 GLU B 1198 REMARK 465 ASN B 1199 REMARK 465 CYS B 1200 REMARK 465 PHE B 1201 REMARK 465 ASN B 1202 REMARK 465 ASN B 1203 REMARK 465 VAL B 1204 REMARK 465 TYR B 1205 REMARK 465 LYS B 1206 REMARK 465 GLY B 1207 REMARK 465 LEU B 1208 REMARK 465 ASN B 1209 REMARK 465 SER B 1210 REMARK 465 VAL B 1211 REMARK 465 ASP B 1212 REMARK 465 ILE B 1213 REMARK 465 THR B 1214 REMARK 465 THR B 1215 REMARK 465 ILE B 1216 REMARK 465 LEU B 1217 REMARK 465 LYS B 1218 REMARK 465 ASN B 1219 REMARK 465 ALA B 1220 REMARK 465 GLN B 1221 REMARK 465 THR B 1222 REMARK 465 TYR B 1223 REMARK 465 ASN B 1224 REMARK 465 ILE B 1225 REMARK 465 ASN B 1226 REMARK 465 ASN B 1227 REMARK 465 LYS B 1228 REMARK 465 LYS B 1229 REMARK 465 THR B 1230 REMARK 465 PRO B 1231 REMARK 465 THR B 1232 REMARK 465 PHE B 1233 REMARK 465 LEU B 1234 REMARK 465 LYS B 1235 REMARK 465 ILE B 1236 REMARK 465 PRO B 1237 REMARK 465 PRO B 1238 REMARK 465 TYR B 1239 REMARK 465 ASN B 1240 REMARK 465 LEU B 1241 REMARK 465 LEU B 1242 REMARK 465 GLU B 1243 REMARK 465 ASP B 1244 REMARK 465 VAL B 1245 REMARK 465 GLU B 1246 REMARK 465 ILE B 1247 REMARK 465 SER B 1248 REMARK 465 CYS B 1249 REMARK 465 GLN B 1250 REMARK 465 CYS B 1251 REMARK 465 THR B 1252 REMARK 465 ILE B 1253 REMARK 465 LYS B 1254 REMARK 465 GLN B 1255 REMARK 465 VAL B 1256 REMARK 465 VAL B 1257 REMARK 465 LYS B 1258 REMARK 465 LYS B 1259 REMARK 465 ILE B 1260 REMARK 465 LYS B 1261 REMARK 465 VAL B 1262 REMARK 465 ILE B 1263 REMARK 465 ILE B 1264 REMARK 465 THR B 1265 REMARK 465 LYS B 1266 REMARK 465 ASN B 1267 REMARK 465 ASP B 1268 REMARK 465 THR B 1269 REMARK 465 VAL B 1270 REMARK 465 LEU B 1271 REMARK 465 LEU B 1272 REMARK 465 LYS B 1273 REMARK 465 ARG B 1274 REMARK 465 GLU B 1275 REMARK 465 VAL B 1276 REMARK 465 GLN B 1277 REMARK 465 SER B 1278 REMARK 465 GLU B 1279 REMARK 465 SER B 1280 REMARK 465 THR B 1281 REMARK 465 LEU B 1282 REMARK 465 ASP B 1283 REMARK 465 ASP B 1284 REMARK 465 LYS B 1285 REMARK 465 ILE B 1286 REMARK 465 TYR B 1287 REMARK 465 LYS B 1288 REMARK 465 CYS B 1289 REMARK 465 GLU B 1290 REMARK 465 HIS B 1291 REMARK 465 GLU B 1292 REMARK 465 ASN B 1293 REMARK 465 PHE B 1294 REMARK 465 ILE B 1295 REMARK 465 ASN B 1296 REMARK 465 PRO B 1297 REMARK 465 ARG B 1298 REMARK 465 VAL B 1299 REMARK 465 ASN B 1300 REMARK 465 LYS B 1301 REMARK 465 THR B 1302 REMARK 465 PHE B 1303 REMARK 465 ASP B 1304 REMARK 465 GLU B 1305 REMARK 465 ASN B 1306 REMARK 465 VAL B 1307 REMARK 465 GLU B 1308 REMARK 465 TYR B 1309 REMARK 465 THR B 1310 REMARK 465 CYS B 1311 REMARK 465 ASN B 1312 REMARK 465 ILE B 1313 REMARK 465 LYS B 1314 REMARK 465 ILE B 1315 REMARK 465 GLU B 1316 REMARK 465 ASN B 1317 REMARK 465 PHE B 1318 REMARK 465 PHE B 1319 REMARK 465 ASN B 1320 REMARK 465 TYR B 1321 REMARK 465 ILE B 1322 REMARK 465 GLN B 1323 REMARK 465 ILE B 1324 REMARK 465 PHE B 1325 REMARK 465 CYS B 1326 REMARK 465 PRO B 1327 REMARK 465 ALA B 1328 REMARK 465 LYS B 1329 REMARK 465 ASP B 1330 REMARK 465 LEU B 1331 REMARK 465 GLY B 1332 REMARK 465 ILE B 1333 REMARK 465 TYR B 1334 REMARK 465 LYS B 1335 REMARK 465 ASN B 1336 REMARK 465 ILE B 1337 REMARK 465 GLN B 1338 REMARK 465 MET B 1339 REMARK 465 TYR B 1340 REMARK 465 TYR B 1341 REMARK 465 ASP B 1342 REMARK 465 ILE B 1343 REMARK 465 VAL B 1344 REMARK 465 LYS B 1345 REMARK 465 PRO B 1346 REMARK 465 THR B 1347 REMARK 465 ARG B 1348 REMARK 465 VAL B 1349 REMARK 465 PRO B 1350 REMARK 465 GLN B 1351 REMARK 465 PHE B 1352 REMARK 465 LYS B 1353 REMARK 465 LYS B 1354 REMARK 465 PHE B 1355 REMARK 465 ASN B 1356 REMARK 465 ASN B 1357 REMARK 465 GLU B 1358 REMARK 465 GLU B 1359 REMARK 465 LEU B 1360 REMARK 465 HIS B 1361 REMARK 465 LYS B 1362 REMARK 465 LEU B 1363 REMARK 465 ILE B 1364 REMARK 465 PRO B 1365 REMARK 465 ASN B 1366 REMARK 465 SER B 1367 REMARK 465 GLU B 1368 REMARK 465 MET B 1369 REMARK 465 LEU B 1370 REMARK 465 HIS B 1371 REMARK 465 LYS B 1372 REMARK 465 THR B 1373 REMARK 465 LYS B 1374 REMARK 465 GLU B 1375 REMARK 465 MET B 1376 REMARK 465 LEU B 1377 REMARK 465 ILE B 1378 REMARK 465 LEU B 1379 REMARK 465 TYR B 1380 REMARK 465 ASN B 1381 REMARK 465 GLU B 1382 REMARK 465 GLU B 1383 REMARK 465 LYS B 1384 REMARK 465 VAL B 1385 REMARK 465 ASP B 1386 REMARK 465 LEU B 1387 REMARK 465 LEU B 1388 REMARK 465 HIS B 1389 REMARK 465 PHE B 1390 REMARK 465 TYR B 1391 REMARK 465 VAL B 1392 REMARK 465 PHE B 1393 REMARK 465 LEU B 1394 REMARK 465 PRO B 1395 REMARK 465 ILE B 1396 REMARK 465 TYR B 1397 REMARK 465 ILE B 1398 REMARK 465 LYS B 1399 REMARK 465 ASP B 1400 REMARK 465 ILE B 1401 REMARK 465 TYR B 1402 REMARK 465 GLU B 1403 REMARK 465 PHE B 1404 REMARK 465 ASN B 1405 REMARK 465 ILE B 1406 REMARK 465 VAL B 1407 REMARK 465 CYS B 1408 REMARK 465 ASP B 1409 REMARK 465 ASN B 1410 REMARK 465 SER B 1411 REMARK 465 LYS B 1412 REMARK 465 THR B 1413 REMARK 465 MET B 1414 REMARK 465 TRP B 1415 REMARK 465 LYS B 1416 REMARK 465 ASN B 1417 REMARK 465 GLN B 1418 REMARK 465 LEU B 1419 REMARK 465 GLY B 1420 REMARK 465 GLY B 1421 REMARK 465 LYS B 1422 REMARK 465 VAL B 1423 REMARK 465 ILE B 1424 REMARK 465 TYR B 1425 REMARK 465 HIS B 1426 REMARK 465 ILE B 1427 REMARK 465 THR B 1428 REMARK 465 VAL B 1429 REMARK 465 SER B 1430 REMARK 465 LYS B 1431 REMARK 465 ARG B 1432 REMARK 465 GLU B 1433 REMARK 465 GLN B 1434 REMARK 465 LYS B 1435 REMARK 465 VAL B 1436 REMARK 465 LYS B 1437 REMARK 465 GLY B 1438 REMARK 465 CYS B 1439 REMARK 465 SER B 1440 REMARK 465 PHE B 1441 REMARK 465 ASP B 1442 REMARK 465 ASN B 1443 REMARK 465 GLU B 1444 REMARK 465 HIS B 1445 REMARK 465 ALA B 1446 REMARK 465 HIS B 1447 REMARK 465 MET B 1448 REMARK 465 PHE B 1449 REMARK 465 SER B 1450 REMARK 465 TYR B 1451 REMARK 465 ASN B 1452 REMARK 465 LYS B 1453 REMARK 465 THR B 1454 REMARK 465 ASN B 1455 REMARK 465 VAL B 1456 REMARK 465 LYS B 1457 REMARK 465 ASN B 1458 REMARK 465 CYS B 1459 REMARK 465 ILE B 1460 REMARK 465 ILE B 1461 REMARK 465 ASP B 1462 REMARK 465 ALA B 1463 REMARK 465 LYS B 1464 REMARK 465 PRO B 1465 REMARK 465 LYS B 1466 REMARK 465 ASP B 1467 REMARK 465 LEU B 1468 REMARK 465 ILE B 1469 REMARK 465 GLY B 1470 REMARK 465 PHE B 1471 REMARK 465 VAL B 1472 REMARK 465 CYS B 1473 REMARK 465 PRO B 1474 REMARK 465 SER B 1475 REMARK 465 GLY B 1476 REMARK 465 THR B 1477 REMARK 465 LEU B 1478 REMARK 465 LYS B 1479 REMARK 465 LEU B 1480 REMARK 465 THR B 1481 REMARK 465 ASN B 1482 REMARK 465 CYS B 1483 REMARK 465 PHE B 1484 REMARK 465 LYS B 1485 REMARK 465 ASP B 1486 REMARK 465 ALA B 1487 REMARK 465 ILE B 1488 REMARK 465 VAL B 1489 REMARK 465 HIS B 1490 REMARK 465 THR B 1491 REMARK 465 ASN B 1492 REMARK 465 LEU B 1493 REMARK 465 THR B 1494 REMARK 465 ASN B 1495 REMARK 465 ILE B 1496 REMARK 465 ASN B 1497 REMARK 465 GLY B 1498 REMARK 465 ILE B 1499 REMARK 465 LEU B 1500 REMARK 465 TYR B 1501 REMARK 465 LEU B 1502 REMARK 465 LYS B 1503 REMARK 465 ASN B 1504 REMARK 465 ASN B 1505 REMARK 465 LEU B 1506 REMARK 465 ALA B 1507 REMARK 465 ASN B 1508 REMARK 465 PHE B 1509 REMARK 465 THR B 1510 REMARK 465 TYR B 1511 REMARK 465 LYS B 1512 REMARK 465 HIS B 1513 REMARK 465 GLN B 1514 REMARK 465 PHE B 1515 REMARK 465 ASN B 1516 REMARK 465 TYR B 1517 REMARK 465 MET B 1518 REMARK 465 GLU B 1519 REMARK 465 ILE B 1520 REMARK 465 PRO B 1521 REMARK 465 ALA B 1522 REMARK 465 LEU B 1523 REMARK 465 MET B 1524 REMARK 465 ASP B 1525 REMARK 465 ASN B 1526 REMARK 465 ASP B 1527 REMARK 465 ILE B 1528 REMARK 465 SER B 1529 REMARK 465 PHE B 1530 REMARK 465 LYS B 1531 REMARK 465 CYS B 1532 REMARK 465 ILE B 1533 REMARK 465 CYS B 1534 REMARK 465 VAL B 1535 REMARK 465 ASP B 1536 REMARK 465 LEU B 1537 REMARK 465 LYS B 1538 REMARK 465 LYS B 1539 REMARK 465 LYS B 1540 REMARK 465 LYS B 1541 REMARK 465 TYR B 1542 REMARK 465 ASN B 1543 REMARK 465 VAL B 1544 REMARK 465 LYS B 1545 REMARK 465 SER B 1546 REMARK 465 PRO B 1547 REMARK 465 LEU B 1548 REMARK 465 GLY B 1549 REMARK 465 PRO B 1550 REMARK 465 LYS B 1551 REMARK 465 VAL B 1552 REMARK 465 LEU B 1553 REMARK 465 ARG B 1554 REMARK 465 ALA B 1555 REMARK 465 LEU B 1556 REMARK 465 TYR B 1557 REMARK 465 LYS B 1558 REMARK 465 LYS B 1559 REMARK 465 LEU B 1560 REMARK 465 ASN B 1561 REMARK 465 ILE B 1562 REMARK 465 LYS B 1563 REMARK 465 PHE B 1564 REMARK 465 ASP B 1565 REMARK 465 ASN B 1566 REMARK 465 TYR B 1567 REMARK 465 VAL B 1568 REMARK 465 THR B 1569 REMARK 465 GLY B 1570 REMARK 465 THR B 1571 REMARK 465 ASP B 1572 REMARK 465 GLN B 1573 REMARK 465 ASN B 1574 REMARK 465 LYS B 1575 REMARK 465 TYR B 1576 REMARK 465 LEU B 1577 REMARK 465 MET B 1578 REMARK 465 THR B 1579 REMARK 465 TYR B 1580 REMARK 465 MET B 1581 REMARK 465 ASP B 1582 REMARK 465 LEU B 1583 REMARK 465 HIS B 1584 REMARK 465 LEU B 1585 REMARK 465 SER B 1586 REMARK 465 HIS B 1587 REMARK 465 LYS B 1588 REMARK 465 ARG B 1589 REMARK 465 ASN B 1590 REMARK 465 TYR B 1591 REMARK 465 LEU B 1592 REMARK 465 LYS B 1593 REMARK 465 GLU B 1594 REMARK 465 LEU B 1595 REMARK 465 PHE B 1596 REMARK 465 HIS B 1597 REMARK 465 ASP B 1598 REMARK 465 LEU B 1599 REMARK 465 GLY B 1600 REMARK 465 LYS B 1601 REMARK 465 LYS B 1602 REMARK 465 LYS B 1603 REMARK 465 PRO B 1604 REMARK 465 ALA B 1605 REMARK 465 ASP B 1606 REMARK 465 THR B 1607 REMARK 465 ASP B 1608 REMARK 465 ALA B 1609 REMARK 465 ASN B 1610 REMARK 465 PRO B 1611 REMARK 465 GLU B 1612 REMARK 465 SER B 1613 REMARK 465 ILE B 1614 REMARK 465 ILE B 1615 REMARK 465 GLU B 1616 REMARK 465 SER B 1617 REMARK 465 LEU B 1618 REMARK 465 SER B 1619 REMARK 465 ILE B 1620 REMARK 465 ASN B 1621 REMARK 465 GLU B 1622 REMARK 465 SER B 1623 REMARK 465 ASN B 1624 REMARK 465 GLU B 1625 REMARK 465 SER B 1626 REMARK 465 GLY B 1627 REMARK 465 PRO B 1628 REMARK 465 PHE B 1629 REMARK 465 PRO B 1630 REMARK 465 THR B 1631 REMARK 465 GLY B 1632 REMARK 465 ASP B 1633 REMARK 465 VAL B 1634 REMARK 465 ASP B 1635 REMARK 465 ALA B 1636 REMARK 465 GLU B 1637 REMARK 465 HIS B 1638 REMARK 465 LEU B 1639 REMARK 465 ILE B 1640 REMARK 465 LEU B 1641 REMARK 465 GLU B 1642 REMARK 465 GLY B 1643 REMARK 465 TYR B 1644 REMARK 465 ASP B 1645 REMARK 465 THR B 1646 REMARK 465 TRP B 1647 REMARK 465 GLU B 1648 REMARK 465 SER B 1649 REMARK 465 LEU B 1650 REMARK 465 TYR B 1651 REMARK 465 ASP B 1652 REMARK 465 GLU B 1653 REMARK 465 GLN B 1654 REMARK 465 LEU B 1655 REMARK 465 GLU B 1656 REMARK 465 GLU B 1657 REMARK 465 VAL B 1658 REMARK 465 ILE B 1659 REMARK 465 TYR B 1660 REMARK 465 ASN B 1661 REMARK 465 ASP B 1662 REMARK 465 ILE B 1663 REMARK 465 GLU B 1664 REMARK 465 SER B 1665 REMARK 465 LEU B 1666 REMARK 465 GLU B 1667 REMARK 465 LEU B 1668 REMARK 465 LYS B 1669 REMARK 465 ASP B 1670 REMARK 465 ILE B 1671 REMARK 465 GLU B 1672 REMARK 465 GLN B 1673 REMARK 465 TYR B 1674 REMARK 465 VAL B 1675 REMARK 465 LEU B 1676 REMARK 465 GLN B 1677 REMARK 465 VAL B 1678 REMARK 465 ASN B 1679 REMARK 465 LEU B 1680 REMARK 465 LYS B 1681 REMARK 465 ASN B 1786 REMARK 465 GLY B 1787 REMARK 465 ASP B 1788 REMARK 465 VAL B 1789 REMARK 465 VAL B 1790 REMARK 465 VAL B 1791 REMARK 465 HIS B 1792 REMARK 465 ASN B 1793 REMARK 465 GLY B 1794 REMARK 465 VAL B 1795 REMARK 465 VAL B 1796 REMARK 465 ASP B 1797 REMARK 465 THR B 1798 REMARK 465 GLY B 1799 REMARK 465 PRO B 1800 REMARK 465 VAL B 1801 REMARK 465 LEU B 1802 REMARK 465 ASP B 2035 REMARK 465 GLU B 2036 REMARK 465 LYS B 2037 REMARK 465 GLU B 2038 REMARK 465 GLU B 2039 REMARK 465 GLU B 2040 REMARK 465 ASP B 2041 REMARK 465 PHE B 2042 REMARK 465 LYS B 2043 REMARK 465 THR B 2044 REMARK 465 ALA B 2045 REMARK 465 GLN B 2046 REMARK 465 GLY B 2047 REMARK 465 ILE B 2048 REMARK 465 LYS B 2049 REMARK 465 HIS B 2050 REMARK 465 ASN B 2051 REMARK 465 ASN B 2052 REMARK 465 VAL B 2053 REMARK 465 HIS B 2054 REMARK 465 LEU B 2055 REMARK 465 CYS B 2056 REMARK 465 ASN B 2057 REMARK 465 PHE B 2058 REMARK 465 PHE B 2059 REMARK 465 ASP B 2060 REMARK 465 ASN B 2061 REMARK 465 PRO B 2062 REMARK 465 GLU B 2063 REMARK 465 LEU B 2064 REMARK 465 THR B 2065 REMARK 465 PHE B 2066 REMARK 465 ASP B 2067 REMARK 465 ASN B 2068 REMARK 465 ASN B 2069 REMARK 465 LYS B 2070 REMARK 465 ILE B 2071 REMARK 465 VAL B 2072 REMARK 465 LEU B 2073 REMARK 465 CYS B 2074 REMARK 465 LYS B 2075 REMARK 465 ILE B 2076 REMARK 465 ASP B 2077 REMARK 465 ALA B 2078 REMARK 465 GLU B 2079 REMARK 465 LEU B 2080 REMARK 465 PHE B 2081 REMARK 465 SER B 2082 REMARK 465 GLU B 2083 REMARK 465 VAL B 2084 REMARK 465 ILE B 2085 REMARK 465 ILE B 2086 REMARK 465 GLN B 2087 REMARK 465 LEU B 2088 REMARK 465 PRO B 2089 REMARK 465 ILE B 2090 REMARK 465 PHE B 2091 REMARK 465 GLY B 2092 REMARK 465 THR B 2093 REMARK 465 LYS B 2094 REMARK 465 ASN B 2095 REMARK 465 VAL B 2096 REMARK 465 GLU B 2097 REMARK 465 GLU B 2098 REMARK 465 GLY B 2099 REMARK 465 VAL B 2100 REMARK 465 GLN B 2101 REMARK 465 ASN B 2102 REMARK 465 GLU B 2103 REMARK 465 GLU B 2104 REMARK 465 TYR B 2105 REMARK 465 LYS B 2106 REMARK 465 LYS B 2107 REMARK 465 PHE B 2108 REMARK 465 SER B 2109 REMARK 465 LEU B 2110 REMARK 465 LYS B 2111 REMARK 465 PRO B 2112 REMARK 465 SER B 2113 REMARK 465 LEU B 2114 REMARK 465 VAL B 2115 REMARK 465 PHE B 2116 REMARK 465 ASP B 2117 REMARK 465 ASP B 2118 REMARK 465 ASN B 2119 REMARK 465 ASN B 2120 REMARK 465 ASN B 2121 REMARK 465 ASP B 2122 REMARK 465 ILE B 2123 REMARK 465 LYS B 2124 REMARK 465 VAL B 2125 REMARK 465 ILE B 2126 REMARK 465 GLY B 2127 REMARK 465 LYS B 2128 REMARK 465 GLU B 2129 REMARK 465 LYS B 2130 REMARK 465 ASN B 2131 REMARK 465 GLU B 2132 REMARK 465 VAL B 2133 REMARK 465 SER B 2134 REMARK 465 ILE B 2135 REMARK 465 SER B 2136 REMARK 465 LEU B 2137 REMARK 465 ALA B 2138 REMARK 465 LEU B 2139 REMARK 465 LYS B 2140 REMARK 465 GLY B 2141 REMARK 465 VAL B 2142 REMARK 465 TYR B 2143 REMARK 465 GLY B 2144 REMARK 465 ASN B 2145 REMARK 465 ARG B 2146 REMARK 465 ILE B 2147 REMARK 465 PHE B 2148 REMARK 465 THR B 2149 REMARK 465 PHE B 2150 REMARK 465 ASP B 2151 REMARK 465 LYS B 2152 REMARK 465 ASN B 2153 REMARK 465 GLY B 2154 REMARK 465 LYS B 2155 REMARK 465 LYS B 2156 REMARK 465 GLY B 2157 REMARK 465 GLU B 2158 REMARK 465 GLY B 2159 REMARK 465 ILE B 2160 REMARK 465 SER B 2161 REMARK 465 PHE B 2162 REMARK 465 PHE B 2163 REMARK 465 ILE B 2164 REMARK 465 PRO B 2165 REMARK 465 PRO B 2166 REMARK 465 ILE B 2167 REMARK 465 LYS B 2168 REMARK 465 GLN B 2169 REMARK 465 ASP B 2170 REMARK 465 THR B 2171 REMARK 465 ASP B 2172 REMARK 465 LEU B 2173 REMARK 465 LYS B 2174 REMARK 465 PHE B 2175 REMARK 465 ILE B 2176 REMARK 465 ILE B 2177 REMARK 465 ASN B 2178 REMARK 465 GLU B 2179 REMARK 465 THR B 2180 REMARK 465 ILE B 2181 REMARK 465 ASP B 2182 REMARK 465 ASN B 2183 REMARK 465 SER B 2184 REMARK 465 ASN B 2185 REMARK 465 ILE B 2186 REMARK 465 LYS B 2187 REMARK 465 GLN B 2188 REMARK 465 ARG B 2189 REMARK 465 GLY B 2190 REMARK 465 LEU B 2191 REMARK 465 ILE B 2192 REMARK 465 TYR B 2193 REMARK 465 ILE B 2194 REMARK 465 PHE B 2195 REMARK 465 VAL B 2196 REMARK 465 ARG B 2197 REMARK 465 LYS B 2198 REMARK 465 ASN B 2199 REMARK 465 VAL B 2200 REMARK 465 SER B 2201 REMARK 465 GLU B 2202 REMARK 465 ASN B 2203 REMARK 465 SER B 2204 REMARK 465 PHE B 2205 REMARK 465 LYS B 2206 REMARK 465 LEU B 2207 REMARK 465 CYS B 2208 REMARK 465 ASP B 2209 REMARK 465 PHE B 2210 REMARK 465 THR B 2211 REMARK 465 THR B 2212 REMARK 465 GLY B 2213 REMARK 465 SER B 2214 REMARK 465 THR B 2215 REMARK 465 SER B 2216 REMARK 465 LEU B 2217 REMARK 465 MET B 2218 REMARK 465 GLU B 2219 REMARK 465 LEU B 2220 REMARK 465 ASN B 2221 REMARK 465 SER B 2222 REMARK 465 GLN B 2223 REMARK 465 VAL B 2224 REMARK 465 LYS B 2225 REMARK 465 GLU B 2226 REMARK 465 LYS B 2227 REMARK 465 LYS B 2228 REMARK 465 CYS B 2229 REMARK 465 THR B 2230 REMARK 465 VAL B 2231 REMARK 465 LYS B 2232 REMARK 465 ILE B 2233 REMARK 465 LYS B 2234 REMARK 465 LYS B 2235 REMARK 465 GLY B 2236 REMARK 465 ASP B 2237 REMARK 465 ILE B 2238 REMARK 465 PHE B 2239 REMARK 465 GLY B 2240 REMARK 465 LEU B 2241 REMARK 465 LYS B 2242 REMARK 465 CYS B 2243 REMARK 465 PRO B 2244 REMARK 465 LYS B 2245 REMARK 465 GLY B 2246 REMARK 465 PHE B 2247 REMARK 465 ALA B 2248 REMARK 465 ILE B 2249 REMARK 465 PHE B 2250 REMARK 465 PRO B 2251 REMARK 465 GLN B 2252 REMARK 465 ALA B 2253 REMARK 465 CYS B 2254 REMARK 465 PHE B 2255 REMARK 465 SER B 2256 REMARK 465 ASN B 2257 REMARK 465 VAL B 2258 REMARK 465 LEU B 2259 REMARK 465 LEU B 2260 REMARK 465 GLU B 2261 REMARK 465 TYR B 2262 REMARK 465 TYR B 2263 REMARK 465 LYS B 2264 REMARK 465 SER B 2265 REMARK 465 ASP B 2266 REMARK 465 TYR B 2267 REMARK 465 GLU B 2268 REMARK 465 ASP B 2269 REMARK 465 SER B 2270 REMARK 465 GLU B 2271 REMARK 465 HIS B 2272 REMARK 465 ILE B 2273 REMARK 465 ASN B 2274 REMARK 465 TYR B 2275 REMARK 465 TYR B 2276 REMARK 465 ILE B 2277 REMARK 465 HIS B 2278 REMARK 465 LYS B 2279 REMARK 465 ASP B 2280 REMARK 465 LYS B 2281 REMARK 465 LYS B 2282 REMARK 465 TYR B 2283 REMARK 465 ASN B 2284 REMARK 465 LEU B 2285 REMARK 465 LYS B 2286 REMARK 465 PRO B 2287 REMARK 465 LYS B 2288 REMARK 465 ASP B 2289 REMARK 465 VAL B 2290 REMARK 465 ILE B 2291 REMARK 465 GLU B 2292 REMARK 465 LEU B 2293 REMARK 465 MET B 2294 REMARK 465 ASP B 2295 REMARK 465 GLU B 2296 REMARK 465 ASN B 2297 REMARK 465 PHE B 2298 REMARK 465 ARG B 2299 REMARK 465 GLU B 2300 REMARK 465 LEU B 2301 REMARK 465 GLN B 2302 REMARK 465 ASN B 2303 REMARK 465 ILE B 2304 REMARK 465 GLN B 2305 REMARK 465 GLN B 2306 REMARK 465 TYR B 2307 REMARK 465 THR B 2308 REMARK 465 GLY B 2309 REMARK 465 ILE B 2310 REMARK 465 SER B 2311 REMARK 465 ASN B 2312 REMARK 465 ILE B 2313 REMARK 465 THR B 2314 REMARK 465 ASP B 2315 REMARK 465 VAL B 2316 REMARK 465 LEU B 2317 REMARK 465 HIS B 2318 REMARK 465 PHE B 2319 REMARK 465 LYS B 2320 REMARK 465 ASN B 2321 REMARK 465 PHE B 2322 REMARK 465 ASN B 2323 REMARK 465 LEU B 2324 REMARK 465 GLY B 2325 REMARK 465 ASN B 2326 REMARK 465 LEU B 2327 REMARK 465 PRO B 2328 REMARK 465 LEU B 2329 REMARK 465 ASN B 2330 REMARK 465 PHE B 2331 REMARK 465 LYS B 2332 REMARK 465 ASN B 2333 REMARK 465 HIS B 2334 REMARK 465 TYR B 2335 REMARK 465 SER B 2336 REMARK 465 THR B 2337 REMARK 465 ALA B 2338 REMARK 465 TYR B 2339 REMARK 465 ALA B 2340 REMARK 465 LYS B 2341 REMARK 465 VAL B 2342 REMARK 465 PRO B 2343 REMARK 465 ASP B 2344 REMARK 465 THR B 2345 REMARK 465 PHE B 2346 REMARK 465 ASN B 2347 REMARK 465 SER B 2348 REMARK 465 ILE B 2349 REMARK 465 ILE B 2350 REMARK 465 ASN B 2351 REMARK 465 PHE B 2352 REMARK 465 SER B 2353 REMARK 465 CYS B 2354 REMARK 465 ASN B 2355 REMARK 465 CYS B 2356 REMARK 465 TYR B 2357 REMARK 465 ASN B 2358 REMARK 465 PRO B 2359 REMARK 465 GLU B 2360 REMARK 465 LYS B 2361 REMARK 465 HIS B 2362 REMARK 465 VAL B 2363 REMARK 465 TYR B 2364 REMARK 465 GLY B 2365 REMARK 465 THR B 2366 REMARK 465 MET B 2367 REMARK 465 GLN B 2368 REMARK 465 VAL B 2369 REMARK 465 GLU B 2370 REMARK 465 SER B 2371 REMARK 465 ASP B 2372 REMARK 465 ASN B 2373 REMARK 465 ARG B 2374 REMARK 465 ASN B 2375 REMARK 465 PHE B 2376 REMARK 465 ASP B 2377 REMARK 465 ASN B 2378 REMARK 465 ILE B 2379 REMARK 465 LYS B 2380 REMARK 465 LYS B 2381 REMARK 465 ASN B 2382 REMARK 465 GLU B 2383 REMARK 465 ASN B 2384 REMARK 465 VAL B 2385 REMARK 465 ILE B 2386 REMARK 465 LYS B 2387 REMARK 465 ASN B 2388 REMARK 465 PHE B 2389 REMARK 465 LEU B 2390 REMARK 465 LEU B 2391 REMARK 465 PRO B 2392 REMARK 465 ASN B 2393 REMARK 465 ILE B 2394 REMARK 465 GLU B 2395 REMARK 465 LYS B 2396 REMARK 465 TYR B 2397 REMARK 465 ALA B 2398 REMARK 465 LEU B 2399 REMARK 465 LEU B 2400 REMARK 465 LEU B 2401 REMARK 465 ASP B 2402 REMARK 465 ASP B 2403 REMARK 465 GLU B 2404 REMARK 465 GLU B 2405 REMARK 465 ARG B 2406 REMARK 465 GLN B 2407 REMARK 465 LYS B 2408 REMARK 465 LYS B 2409 REMARK 465 ILE B 2410 REMARK 465 LYS B 2411 REMARK 465 GLN B 2412 REMARK 465 GLN B 2413 REMARK 465 GLN B 2414 REMARK 465 GLU B 2415 REMARK 465 GLU B 2416 REMARK 465 GLU B 2417 REMARK 465 GLN B 2418 REMARK 465 GLN B 2419 REMARK 465 GLU B 2420 REMARK 465 GLN B 2421 REMARK 465 ILE B 2422 REMARK 465 LEU B 2423 REMARK 465 LYS B 2424 REMARK 465 ASP B 2425 REMARK 465 GLN B 2426 REMARK 465 ASP B 2427 REMARK 465 ASP B 2428 REMARK 465 ARG B 2429 REMARK 465 LEU B 2430 REMARK 465 SER B 2431 REMARK 465 ARG B 2432 REMARK 465 HIS B 2433 REMARK 465 ASP B 2434 REMARK 465 ASP B 2435 REMARK 465 TYR B 2436 REMARK 465 ASN B 2437 REMARK 465 LYS B 2438 REMARK 465 ASN B 2439 REMARK 465 HIS B 2440 REMARK 465 THR B 2441 REMARK 465 TYR B 2442 REMARK 465 ILE B 2443 REMARK 465 LEU B 2444 REMARK 465 TYR B 2445 REMARK 465 ASP B 2446 REMARK 465 SER B 2447 REMARK 465 ASN B 2448 REMARK 465 GLU B 2449 REMARK 465 HIS B 2450 REMARK 465 ILE B 2451 REMARK 465 CYS B 2452 REMARK 465 ASP B 2453 REMARK 465 TYR B 2454 REMARK 465 GLU B 2455 REMARK 465 LYS B 2456 REMARK 465 ASN B 2457 REMARK 465 GLU B 2458 REMARK 465 SER B 2459 REMARK 465 LEU B 2460 REMARK 465 ILE B 2461 REMARK 465 SER B 2462 REMARK 465 THR B 2463 REMARK 465 LEU B 2464 REMARK 465 PRO B 2465 REMARK 465 ASN B 2466 REMARK 465 ASP B 2467 REMARK 465 THR B 2468 REMARK 465 LYS B 2469 REMARK 465 LYS B 2470 REMARK 465 ILE B 2471 REMARK 465 GLN B 2472 REMARK 465 LYS B 2473 REMARK 465 SER B 2474 REMARK 465 ILE B 2475 REMARK 465 CYS B 2476 REMARK 465 LYS B 2477 REMARK 465 ILE B 2478 REMARK 465 ASN B 2479 REMARK 465 ALA B 2480 REMARK 465 LYS B 2481 REMARK 465 ALA B 2482 REMARK 465 LEU B 2483 REMARK 465 ASP B 2484 REMARK 465 VAL B 2485 REMARK 465 VAL B 2486 REMARK 465 THR B 2487 REMARK 465 ILE B 2488 REMARK 465 LYS B 2489 REMARK 465 CYS B 2490 REMARK 465 PRO B 2491 REMARK 465 HIS B 2492 REMARK 465 THR B 2493 REMARK 465 LYS B 2494 REMARK 465 ASN B 2495 REMARK 465 PHE B 2496 REMARK 465 THR B 2497 REMARK 465 PRO B 2498 REMARK 465 LYS B 2499 REMARK 465 ASP B 2500 REMARK 465 TYR B 2501 REMARK 465 PHE B 2502 REMARK 465 PRO B 2503 REMARK 465 ASN B 2504 REMARK 465 SER B 2505 REMARK 465 SER B 2506 REMARK 465 LEU B 2507 REMARK 465 ILE B 2508 REMARK 465 THR B 2509 REMARK 465 ASN B 2510 REMARK 465 ASP B 2511 REMARK 465 LYS B 2512 REMARK 465 LYS B 2513 REMARK 465 ILE B 2514 REMARK 465 VAL B 2515 REMARK 465 ILE B 2516 REMARK 465 THR B 2517 REMARK 465 PHE B 2518 REMARK 465 ASP B 2519 REMARK 465 LYS B 2520 REMARK 465 LYS B 2521 REMARK 465 ASN B 2522 REMARK 465 PHE B 2523 REMARK 465 VAL B 2524 REMARK 465 THR B 2525 REMARK 465 TYR B 2526 REMARK 465 ILE B 2527 REMARK 465 ASP B 2528 REMARK 465 PRO B 2529 REMARK 465 THR B 2530 REMARK 465 LYS B 2531 REMARK 465 LYS B 2532 REMARK 465 THR B 2533 REMARK 465 PHE B 2534 REMARK 465 SER B 2535 REMARK 465 LEU B 2536 REMARK 465 LYS B 2537 REMARK 465 ASP B 2538 REMARK 465 ILE B 2539 REMARK 465 TYR B 2540 REMARK 465 ILE B 2541 REMARK 465 GLN B 2542 REMARK 465 SER B 2543 REMARK 465 PHE B 2544 REMARK 465 TYR B 2545 REMARK 465 GLY B 2546 REMARK 465 VAL B 2547 REMARK 465 SER B 2548 REMARK 465 LEU B 2549 REMARK 465 ASP B 2550 REMARK 465 HIS B 2551 REMARK 465 LEU B 2552 REMARK 465 ASN B 2553 REMARK 465 GLN B 2554 REMARK 465 ILE B 2555 REMARK 465 LYS B 2556 REMARK 465 LYS B 2557 REMARK 465 ILE B 2558 REMARK 465 HIS B 2559 REMARK 465 GLU B 2560 REMARK 465 GLU B 2561 REMARK 465 TRP B 2562 REMARK 465 ASP B 2563 REMARK 465 ASP B 2564 REMARK 465 VAL B 2565 REMARK 465 HIS B 2566 REMARK 465 LEU B 2567 REMARK 465 PHE B 2568 REMARK 465 TYR B 2569 REMARK 465 PRO B 2570 REMARK 465 PRO B 2571 REMARK 465 HIS B 2572 REMARK 465 ASN B 2573 REMARK 465 VAL B 2574 REMARK 465 LEU B 2575 REMARK 465 HIS B 2576 REMARK 465 ASN B 2577 REMARK 465 VAL B 2578 REMARK 465 VAL B 2579 REMARK 465 LEU B 2580 REMARK 465 ASN B 2581 REMARK 465 ASN B 2582 REMARK 465 HIS B 2583 REMARK 465 ILE B 2584 REMARK 465 VAL B 2585 REMARK 465 ASN B 2586 REMARK 465 LEU B 2587 REMARK 465 SER B 2588 REMARK 465 SER B 2589 REMARK 465 ALA B 2590 REMARK 465 LEU B 2591 REMARK 465 GLU B 2592 REMARK 465 GLY B 2593 REMARK 465 VAL B 2594 REMARK 465 LEU B 2595 REMARK 465 PHE B 2596 REMARK 465 MET B 2597 REMARK 465 LYS B 2598 REMARK 465 SER B 2599 REMARK 465 LYS B 2600 REMARK 465 VAL B 2601 REMARK 465 THR B 2602 REMARK 465 GLY B 2603 REMARK 465 ASP B 2604 REMARK 465 GLU B 2605 REMARK 465 THR B 2606 REMARK 465 ALA B 2607 REMARK 465 THR B 2608 REMARK 465 LYS B 2609 REMARK 465 LYS B 2610 REMARK 465 ASN B 2611 REMARK 465 THR B 2612 REMARK 465 THR B 2613 REMARK 465 LEU B 2614 REMARK 465 PRO B 2615 REMARK 465 THR B 2616 REMARK 465 ASP B 2617 REMARK 465 GLY B 2618 REMARK 465 VAL B 2619 REMARK 465 SER B 2620 REMARK 465 SER B 2621 REMARK 465 ILE B 2622 REMARK 465 LEU B 2623 REMARK 465 ILE B 2624 REMARK 465 PRO B 2625 REMARK 465 PRO B 2626 REMARK 465 TYR B 2627 REMARK 465 VAL B 2628 REMARK 465 LYS B 2629 REMARK 465 GLU B 2630 REMARK 465 ASP B 2631 REMARK 465 ILE B 2632 REMARK 465 THR B 2633 REMARK 465 PHE B 2634 REMARK 465 HIS B 2635 REMARK 465 LEU B 2636 REMARK 465 PHE B 2637 REMARK 465 CYS B 2638 REMARK 465 GLY B 2639 REMARK 465 LYS B 2640 REMARK 465 SER B 2641 REMARK 465 THR B 2642 REMARK 465 THR B 2643 REMARK 465 LYS B 2644 REMARK 465 LYS B 2645 REMARK 465 PRO B 2646 REMARK 465 ASN B 2647 REMARK 465 LYS B 2648 REMARK 465 LYS B 2649 REMARK 465 ASN B 2650 REMARK 465 THR B 2651 REMARK 465 SER B 2652 REMARK 465 LEU B 2653 REMARK 465 ALA B 2654 REMARK 465 LEU B 2655 REMARK 465 ILE B 2656 REMARK 465 HIS B 2657 REMARK 465 ILE B 2658 REMARK 465 HIS B 2659 REMARK 465 ILE B 2660 REMARK 465 SER B 2661 REMARK 465 SER B 2662 REMARK 465 ASN B 2663 REMARK 465 ARG B 2664 REMARK 465 ASN B 2665 REMARK 465 ILE B 2666 REMARK 465 ILE B 2667 REMARK 465 HIS B 2668 REMARK 465 GLY B 2669 REMARK 465 CYS B 2670 REMARK 465 ASP B 2671 REMARK 465 PHE B 2672 REMARK 465 LEU B 2673 REMARK 465 TYR B 2674 REMARK 465 LEU B 2675 REMARK 465 GLU B 2676 REMARK 465 ASN B 2677 REMARK 465 GLN B 2678 REMARK 465 THR B 2679 REMARK 465 ASN B 2680 REMARK 465 ASP B 2681 REMARK 465 ALA B 2682 REMARK 465 ILE B 2683 REMARK 465 SER B 2684 REMARK 465 ASN B 2685 REMARK 465 ASN B 2686 REMARK 465 ASN B 2687 REMARK 465 ASN B 2688 REMARK 465 ASN B 2689 REMARK 465 SER B 2690 REMARK 465 TYR B 2691 REMARK 465 SER B 2692 REMARK 465 ILE B 2693 REMARK 465 PHE B 2694 REMARK 465 THR B 2695 REMARK 465 HIS B 2696 REMARK 465 ASN B 2697 REMARK 465 LYS B 2698 REMARK 465 ASN B 2699 REMARK 465 THR B 2700 REMARK 465 GLU B 2701 REMARK 465 ASN B 2702 REMARK 465 ASN B 2703 REMARK 465 LEU B 2704 REMARK 465 ILE B 2705 REMARK 465 CYS B 2706 REMARK 465 ASP B 2707 REMARK 465 ILE B 2708 REMARK 465 SER B 2709 REMARK 465 LEU B 2710 REMARK 465 ILE B 2711 REMARK 465 PRO B 2712 REMARK 465 LYS B 2713 REMARK 465 THR B 2714 REMARK 465 VAL B 2715 REMARK 465 ILE B 2716 REMARK 465 GLY B 2717 REMARK 465 ILE B 2718 REMARK 465 LYS B 2719 REMARK 465 CYS B 2720 REMARK 465 PRO B 2721 REMARK 465 ASN B 2722 REMARK 465 LYS B 2723 REMARK 465 LYS B 2724 REMARK 465 LEU B 2725 REMARK 465 ASN B 2726 REMARK 465 PRO B 2727 REMARK 465 GLN B 2728 REMARK 465 THR B 2729 REMARK 465 CYS B 2730 REMARK 465 PHE B 2731 REMARK 465 ASP B 2732 REMARK 465 GLU B 2733 REMARK 465 VAL B 2734 REMARK 465 TYR B 2735 REMARK 465 TYR B 2736 REMARK 465 VAL B 2737 REMARK 465 LYS B 2738 REMARK 465 GLN B 2739 REMARK 465 GLU B 2740 REMARK 465 ASP B 2741 REMARK 465 VAL B 2742 REMARK 465 PRO B 2743 REMARK 465 SER B 2744 REMARK 465 LYS B 2745 REMARK 465 THR B 2746 REMARK 465 ILE B 2747 REMARK 465 THR B 2748 REMARK 465 ALA B 2749 REMARK 465 ASP B 2750 REMARK 465 LYS B 2751 REMARK 465 TYR B 2752 REMARK 465 ASN B 2753 REMARK 465 THR B 2754 REMARK 465 PHE B 2755 REMARK 465 SER B 2756 REMARK 465 LYS B 2757 REMARK 465 ASP B 2758 REMARK 465 LYS B 2759 REMARK 465 ILE B 2760 REMARK 465 GLY B 2761 REMARK 465 ASN B 2762 REMARK 465 ILE B 2763 REMARK 465 LEU B 2764 REMARK 465 LYS B 2765 REMARK 465 ASN B 2766 REMARK 465 ALA B 2767 REMARK 465 ILE B 2768 REMARK 465 SER B 2769 REMARK 465 ILE B 2770 REMARK 465 ASN B 2771 REMARK 465 ASN B 2772 REMARK 465 PRO B 2773 REMARK 465 ASP B 2774 REMARK 465 GLU B 2775 REMARK 465 LYS B 2776 REMARK 465 ASP B 2777 REMARK 465 ASN B 2778 REMARK 465 THR B 2779 REMARK 465 TYR B 2780 REMARK 465 THR B 2781 REMARK 465 TYR B 2782 REMARK 465 LEU B 2783 REMARK 465 ILE B 2784 REMARK 465 LEU B 2785 REMARK 465 PRO B 2786 REMARK 465 GLU B 2787 REMARK 465 LYS B 2788 REMARK 465 PHE B 2789 REMARK 465 GLU B 2790 REMARK 465 GLU B 2791 REMARK 465 GLU B 2792 REMARK 465 LEU B 2793 REMARK 465 ILE B 2794 REMARK 465 ASP B 2795 REMARK 465 THR B 2796 REMARK 465 LYS B 2797 REMARK 465 LYS B 2798 REMARK 465 VAL B 2799 REMARK 465 LEU B 2800 REMARK 465 ALA B 2801 REMARK 465 CYS B 2802 REMARK 465 THR B 2803 REMARK 465 CYS B 2804 REMARK 465 ASP B 2805 REMARK 465 ASN B 2806 REMARK 465 LYS B 2807 REMARK 465 TYR B 2808 REMARK 465 ILE B 2809 REMARK 465 ILE B 2810 REMARK 465 HIS B 2811 REMARK 465 MET B 2812 REMARK 465 LYS B 2813 REMARK 465 ILE B 2814 REMARK 465 GLU B 2815 REMARK 465 LYS B 2816 REMARK 465 SER B 2817 REMARK 465 THR B 2818 REMARK 465 MET B 2819 REMARK 465 ASP B 2820 REMARK 465 LYS B 2821 REMARK 465 ILE B 2822 REMARK 465 LYS B 2823 REMARK 465 ILE B 2824 REMARK 465 ASP B 2825 REMARK 465 GLU B 2826 REMARK 465 LYS B 2827 REMARK 465 LYS B 2828 REMARK 465 THR B 2829 REMARK 465 ILE B 2830 REMARK 465 GLY B 2831 REMARK 465 LYS B 2832 REMARK 465 ASP B 2833 REMARK 465 ILE B 2834 REMARK 465 CYS B 2835 REMARK 465 LYS B 2836 REMARK 465 TYR B 2837 REMARK 465 ASP B 2838 REMARK 465 VAL B 2839 REMARK 465 THR B 2840 REMARK 465 THR B 2841 REMARK 465 LYS B 2842 REMARK 465 VAL B 2843 REMARK 465 ALA B 2844 REMARK 465 THR B 2845 REMARK 465 CYS B 2846 REMARK 465 GLU B 2847 REMARK 465 ILE B 2848 REMARK 465 ILE B 2849 REMARK 465 ASP B 2850 REMARK 465 THR B 2851 REMARK 465 ILE B 2852 REMARK 465 ASP B 2853 REMARK 465 SER B 2854 REMARK 465 SER B 2855 REMARK 465 VAL B 2856 REMARK 465 LEU B 2857 REMARK 465 LYS B 2858 REMARK 465 GLU B 2859 REMARK 465 HIS B 2860 REMARK 465 HIS B 2861 REMARK 465 THR B 2862 REMARK 465 VAL B 2863 REMARK 465 HIS B 2864 REMARK 465 TYR B 2865 REMARK 465 SER B 2866 REMARK 465 ILE B 2867 REMARK 465 THR B 2868 REMARK 465 LEU B 2869 REMARK 465 SER B 2870 REMARK 465 ARG B 2871 REMARK 465 TRP B 2872 REMARK 465 ASP B 2873 REMARK 465 LYS B 2874 REMARK 465 LEU B 2875 REMARK 465 ILE B 2876 REMARK 465 ILE B 2877 REMARK 465 LYS B 2878 REMARK 465 TYR B 2879 REMARK 465 PRO B 2880 REMARK 465 THR B 2881 REMARK 465 ASN B 2882 REMARK 465 GLU B 2883 REMARK 465 LYS B 2884 REMARK 465 THR B 2885 REMARK 465 HIS B 2886 REMARK 465 PHE B 2887 REMARK 465 GLU B 2888 REMARK 465 ASN B 2889 REMARK 465 PHE B 2890 REMARK 465 PHE B 2891 REMARK 465 VAL B 2892 REMARK 465 ASN B 2893 REMARK 465 PRO B 2894 REMARK 465 PHE B 2895 REMARK 465 ASN B 2896 REMARK 465 LEU B 2897 REMARK 465 LYS B 2898 REMARK 465 ASP B 2899 REMARK 465 LYS B 2900 REMARK 465 VAL B 2901 REMARK 465 LEU B 2902 REMARK 465 TYR B 2903 REMARK 465 ASN B 2904 REMARK 465 TYR B 2905 REMARK 465 ASN B 2906 REMARK 465 LYS B 2907 REMARK 465 PRO B 2908 REMARK 465 ILE B 2909 REMARK 465 ASN B 2910 REMARK 465 ILE B 2911 REMARK 465 GLU B 2912 REMARK 465 HIS B 2913 REMARK 465 ILE B 2914 REMARK 465 LEU B 2915 REMARK 465 PRO B 2916 REMARK 465 GLY B 2917 REMARK 465 ALA B 2918 REMARK 465 ILE B 2919 REMARK 465 THR B 2920 REMARK 465 THR B 2921 REMARK 465 ASP B 2922 REMARK 465 ILE B 2923 REMARK 465 TYR B 2924 REMARK 465 ASP B 2925 REMARK 465 THR B 2926 REMARK 465 ARG B 2927 REMARK 465 THR B 2928 REMARK 465 LYS B 2929 REMARK 465 ILE B 2930 REMARK 465 LYS B 2931 REMARK 465 GLN B 2932 REMARK 465 TYR B 2933 REMARK 465 ILE B 2934 REMARK 465 LEU B 2935 REMARK 465 ARG B 2936 REMARK 465 ILE B 2937 REMARK 465 PRO B 2938 REMARK 465 PRO B 2939 REMARK 465 TYR B 2940 REMARK 465 VAL B 2941 REMARK 465 HIS B 2942 REMARK 465 LYS B 2943 REMARK 465 ASP B 2944 REMARK 465 ILE B 2945 REMARK 465 HIS B 2946 REMARK 465 PHE B 2947 REMARK 465 SER B 2948 REMARK 465 LEU B 2949 REMARK 465 GLU B 2950 REMARK 465 PHE B 2951 REMARK 465 ASN B 2952 REMARK 465 ASN B 2953 REMARK 465 SER B 2954 REMARK 465 LEU B 2955 REMARK 465 SER B 2956 REMARK 465 LEU B 2957 REMARK 465 THR B 2958 REMARK 465 LYS B 2959 REMARK 465 GLN B 2960 REMARK 465 ASN B 2961 REMARK 465 GLN B 2962 REMARK 465 ASN B 2963 REMARK 465 ILE B 2964 REMARK 465 ILE B 2965 REMARK 465 TYR B 2966 REMARK 465 GLY B 2967 REMARK 465 ASN B 2968 REMARK 465 VAL B 2969 REMARK 465 ALA B 2970 REMARK 465 LYS B 2971 REMARK 465 ILE B 2972 REMARK 465 PHE B 2973 REMARK 465 ILE B 2974 REMARK 465 HIS B 2975 REMARK 465 ILE B 2976 REMARK 465 ASN B 2977 REMARK 465 GLN B 2978 REMARK 465 GLY B 2979 REMARK 465 TYR B 2980 REMARK 465 LYS B 2981 REMARK 465 GLU B 2982 REMARK 465 ILE B 2983 REMARK 465 HIS B 2984 REMARK 465 GLY B 2985 REMARK 465 CYS B 2986 REMARK 465 ASP B 2987 REMARK 465 PHE B 2988 REMARK 465 THR B 2989 REMARK 465 GLY B 2990 REMARK 465 LYS B 2991 REMARK 465 TYR B 2992 REMARK 465 SER B 2993 REMARK 465 HIS B 2994 REMARK 465 LEU B 2995 REMARK 465 PHE B 2996 REMARK 465 THR B 2997 REMARK 465 TYR B 2998 REMARK 465 SER B 2999 REMARK 465 LYS B 3000 REMARK 465 LYS B 3001 REMARK 465 PRO B 3002 REMARK 465 LEU B 3003 REMARK 465 PRO B 3004 REMARK 465 ASN B 3005 REMARK 465 ASP B 3006 REMARK 465 ASP B 3007 REMARK 465 ASP B 3008 REMARK 465 ILE B 3009 REMARK 465 CYS B 3010 REMARK 465 ASN B 3011 REMARK 465 VAL B 3012 REMARK 465 THR B 3013 REMARK 465 ILE B 3014 REMARK 465 GLY B 3015 REMARK 465 ASN B 3016 REMARK 465 ASN B 3017 REMARK 465 THR B 3018 REMARK 465 PHE B 3019 REMARK 465 SER B 3020 REMARK 465 GLY B 3021 REMARK 465 PHE B 3022 REMARK 465 ALA B 3023 REMARK 465 CYS B 3024 REMARK 465 LEU B 3025 REMARK 465 SER B 3026 REMARK 465 HIS B 3027 REMARK 465 PHE B 3028 REMARK 465 GLU B 3029 REMARK 465 LEU B 3030 REMARK 465 LYS B 3031 REMARK 465 PRO B 3032 REMARK 465 ASN B 3033 REMARK 465 ASN B 3034 REMARK 465 CYS B 3035 REMARK 465 PHE B 3036 REMARK 465 SER B 3037 REMARK 465 SER B 3038 REMARK 465 VAL B 3039 REMARK 465 TYR B 3040 REMARK 465 ASP B 3041 REMARK 465 TYR B 3042 REMARK 465 ASN B 3043 REMARK 465 GLU B 3044 REMARK 465 ALA B 3045 REMARK 465 ASN B 3046 REMARK 465 LYS B 3047 REMARK 465 VAL B 3048 REMARK 465 LYS B 3049 REMARK 465 LYS B 3050 REMARK 465 LEU B 3051 REMARK 465 PHE B 3052 REMARK 465 ASP B 3053 REMARK 465 LEU B 3054 REMARK 465 SER B 3055 REMARK 465 THR B 3056 REMARK 465 LYS B 3057 REMARK 465 VAL B 3058 REMARK 465 GLU B 3059 REMARK 465 LEU B 3060 REMARK 465 ASP B 3061 REMARK 465 HIS B 3062 REMARK 465 ILE B 3063 REMARK 465 LYS B 3064 REMARK 465 GLN B 3065 REMARK 465 ASN B 3066 REMARK 465 THR B 3067 REMARK 465 SER B 3068 REMARK 465 GLY B 3069 REMARK 465 TYR B 3070 REMARK 465 THR B 3071 REMARK 465 LEU B 3072 REMARK 465 SER B 3073 REMARK 465 TYR B 3074 REMARK 465 ILE B 3075 REMARK 465 ILE B 3076 REMARK 465 PHE B 3077 REMARK 465 ASN B 3078 REMARK 465 LYS B 3079 REMARK 465 GLU B 3080 REMARK 465 SER B 3081 REMARK 465 THR B 3082 REMARK 465 LYS B 3083 REMARK 465 LEU B 3084 REMARK 465 LYS B 3085 REMARK 465 PHE B 3086 REMARK 465 SER B 3087 REMARK 465 CYS B 3088 REMARK 465 THR B 3089 REMARK 465 CYS B 3090 REMARK 465 SER B 3091 REMARK 465 SER B 3092 REMARK 465 ASN B 3093 REMARK 465 TYR B 3094 REMARK 465 SER B 3095 REMARK 465 ASN B 3096 REMARK 465 TYR B 3097 REMARK 465 THR B 3098 REMARK 465 ILE B 3099 REMARK 465 ARG B 3100 REMARK 465 ILE B 3101 REMARK 465 THR B 3102 REMARK 465 PHE B 3103 REMARK 465 ASP B 3104 REMARK 465 PRO B 3105 REMARK 465 ASN B 3106 REMARK 465 TYR B 3107 REMARK 465 ILE B 3108 REMARK 465 ILE B 3109 REMARK 465 PRO B 3110 REMARK 465 GLU B 3111 REMARK 465 PRO B 3112 REMARK 465 GLN B 3113 REMARK 465 SER B 3114 REMARK 465 ARG B 3115 REMARK 465 ALA B 3116 REMARK 465 ILE B 3117 REMARK 465 ILE B 3118 REMARK 465 LYS B 3119 REMARK 465 TYR B 3120 REMARK 465 VAL B 3121 REMARK 465 ASP B 3122 REMARK 465 LEU B 3123 REMARK 465 GLN B 3124 REMARK 465 ASP B 3125 REMARK 465 LYS B 3126 REMARK 465 ASN B 3127 REMARK 465 PHE B 3128 REMARK 465 ALA B 3129 REMARK 465 LYS B 3130 REMARK 465 TYR B 3131 REMARK 465 LEU B 3132 REMARK 465 ARG B 3133 REMARK 465 LYS B 3134 REMARK 465 LEU B 3135 REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 LYS H 117 REMARK 465 GLY H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 PHE H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 SER H 128 REMARK 465 LYS H 129 REMARK 465 SER H 130 REMARK 465 THR H 131 REMARK 465 SER H 132 REMARK 465 GLY H 133 REMARK 465 GLY H 134 REMARK 465 THR H 135 REMARK 465 ALA H 136 REMARK 465 ALA H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 ASP H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 SER H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 ALA H 158 REMARK 465 LEU H 159 REMARK 465 THR H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 SER H 173 REMARK 465 GLY H 174 REMARK 465 LEU H 175 REMARK 465 TYR H 176 REMARK 465 SER H 177 REMARK 465 LEU H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 VAL H 182 REMARK 465 THR H 183 REMARK 465 VAL H 184 REMARK 465 PRO H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 SER H 188 REMARK 465 LEU H 189 REMARK 465 GLY H 190 REMARK 465 THR H 191 REMARK 465 GLN H 192 REMARK 465 THR H 193 REMARK 465 TYR H 194 REMARK 465 ILE H 195 REMARK 465 CYS H 196 REMARK 465 ASN H 197 REMARK 465 VAL H 198 REMARK 465 ASN H 199 REMARK 465 HIS H 200 REMARK 465 LYS H 201 REMARK 465 PRO H 202 REMARK 465 SER H 203 REMARK 465 ASN H 204 REMARK 465 THR H 205 REMARK 465 LYS H 206 REMARK 465 VAL H 207 REMARK 465 ASP H 208 REMARK 465 LYS H 209 REMARK 465 LYS H 210 REMARK 465 VAL H 211 REMARK 465 GLU H 212 REMARK 465 PRO H 213 REMARK 465 LYS H 214 REMARK 465 SER H 215 REMARK 465 CYS H 216 REMARK 465 ILE L 106 REMARK 465 LYS L 107 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 HIS B1692 -150.03 54.21 REMARK 500 ASN B1694 18.20 -149.38 REMARK 500 GLU B1777 -136.84 48.09 REMARK 500 PHE B1811 7.08 -67.92 REMARK 500 ASN B1813 91.83 63.76 REMARK 500 ASP B1819 -129.49 59.05 REMARK 500 LYS B1873 -120.92 58.61 REMARK 500 GLU B1885 -168.93 -173.92 REMARK 500 SER B1894 142.52 -174.56 REMARK 500 CYS B1914 66.59 61.99 REMARK 500 LEU B1930 168.73 66.04 REMARK 500 PHE B1978 21.36 -76.15 REMARK 500 PHE B1988 61.44 -100.17 REMARK 500 ASN B1992 31.36 -96.87 REMARK 500 THR B2022 -13.84 71.80 REMARK 500 PHE H 48 -61.63 -94.37 REMARK 500 THR L 30 -122.17 48.35 REMARK 500 ALA L 51 -25.04 70.95 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-48941 RELATED DB: EMDB REMARK 900 ENDOGENOUS PFS230D7-8 IN COMPLEX WITH 18F25 DBREF 9N5O B 1 3135 UNP P68874 P230_PLAF7 1 3135 DBREF 9N5O H 1 216 PDB 9N5O 9N5O 1 216 DBREF 9N5O L 1 214 PDB 9N5O 9N5O 1 214 SEQRES 1 B 3135 MET LYS LYS ILE ILE THR LEU LYS ASN LEU PHE LEU ILE SEQRES 2 B 3135 ILE LEU VAL TYR ILE PHE SER GLU LYS LYS ASP LEU ARG SEQRES 3 B 3135 CYS ASN VAL ILE LYS GLY ASN ASN ILE LYS ASP ASP GLU SEQRES 4 B 3135 ASP LYS ARG PHE HIS LEU PHE TYR TYR SER HIS ASN LEU SEQRES 5 B 3135 PHE LYS THR PRO GLU THR LYS GLU LYS LYS ASN LYS LYS SEQRES 6 B 3135 GLU CYS PHE TYR LYS ASN GLY GLY ILE TYR ASN LEU SER SEQRES 7 B 3135 LYS GLU ILE ARG MET ARG LYS ASP THR SER VAL LYS ILE SEQRES 8 B 3135 LYS GLN ARG THR CYS PRO PHE HIS LYS GLU GLY SER SER SEQRES 9 B 3135 PHE GLU MET GLY SER LYS ASN ILE THR CYS PHE TYR PRO SEQRES 10 B 3135 ILE VAL GLY LYS LYS GLU ARG LYS THR LEU ASP THR ILE SEQRES 11 B 3135 ILE ILE LYS LYS ASN VAL THR ASN ASP HIS VAL VAL SER SEQRES 12 B 3135 SER ASP MET HIS SER ASN VAL GLN GLU LYS ASN MET ILE SEQRES 13 B 3135 LEU ILE ARG ASN ILE ASP LYS GLU ASN LYS ASN ASP ILE SEQRES 14 B 3135 GLN ASN VAL GLU GLU LYS ILE GLN ARG ASP THR TYR GLU SEQRES 15 B 3135 ASN LYS ASP TYR GLU SER ASP ASP THR LEU ILE GLU TRP SEQRES 16 B 3135 PHE ASP ASP ASN THR ASN GLU GLU ASN PHE LEU LEU THR SEQRES 17 B 3135 PHE LEU LYS ARG CYS LEU MET LYS ILE PHE SER SER PRO SEQRES 18 B 3135 LYS ARG LYS LYS THR VAL VAL GLN LYS LYS HIS LYS SER SEQRES 19 B 3135 ASN PHE PHE ILE ASN SER SER LEU LYS TYR ILE TYR MET SEQRES 20 B 3135 TYR LEU THR PRO SER ASP SER PHE ASN LEU VAL ARG ARG SEQRES 21 B 3135 ASN ARG ASN LEU ASP GLU GLU ASP MET SER PRO ARG ASP SEQRES 22 B 3135 ASN PHE VAL ILE ASP ASP GLU GLU GLU GLU GLU GLU GLU SEQRES 23 B 3135 GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU SEQRES 24 B 3135 GLU GLU GLU GLU GLU TYR ASP ASP TYR VAL TYR GLU GLU SEQRES 25 B 3135 SER GLY ASP GLU THR GLU GLU GLN LEU GLN GLU GLU HIS SEQRES 26 B 3135 GLN GLU GLU VAL GLY ALA GLU SER SER GLU GLU SER PHE SEQRES 27 B 3135 ASN ASP GLU ASP GLU ASP SER VAL GLU ALA ARG ASP GLY SEQRES 28 B 3135 ASP MET ILE ARG VAL ASP GLU TYR TYR GLU ASP GLN ASP SEQRES 29 B 3135 GLY ASP THR TYR ASP SER THR ILE LYS ASN GLU ASP VAL SEQRES 30 B 3135 ASP GLU GLU VAL GLY GLU GLU VAL GLY GLU GLU VAL GLY SEQRES 31 B 3135 GLU GLU VAL GLY GLU GLU VAL GLY GLU GLU VAL GLY GLU SEQRES 32 B 3135 GLU VAL GLY GLU GLU VAL GLY GLU GLU VAL GLY GLU GLU SEQRES 33 B 3135 GLU GLY GLU GLU VAL GLY GLU GLY VAL GLY GLU GLU VAL SEQRES 34 B 3135 GLY GLU GLU GLU GLY GLU GLU VAL GLY GLU GLU GLU GLY SEQRES 35 B 3135 GLU TYR VAL ASP GLU LYS GLU ARG GLN GLY GLU ILE TYR SEQRES 36 B 3135 PRO PHE GLY ASP GLU GLU GLU LYS ASP GLU GLY GLY GLU SEQRES 37 B 3135 SER PHE THR TYR GLU LYS SER GLU VAL ASP LYS THR ASP SEQRES 38 B 3135 LEU PHE LYS PHE ILE GLU GLY GLY GLU GLY ASP ASP VAL SEQRES 39 B 3135 TYR LYS VAL ASP GLY SER LYS VAL LEU LEU ASP ASP ASP SEQRES 40 B 3135 THR ILE SER ARG VAL SER LYS LYS HIS THR ALA ARG ASP SEQRES 41 B 3135 GLY GLU TYR GLY GLU TYR GLY GLU ALA VAL GLU ASP GLY SEQRES 42 B 3135 GLU ASN VAL ILE LYS ILE ILE ARG SER VAL LEU GLN SER SEQRES 43 B 3135 GLY ALA LEU PRO SER VAL GLY VAL ASP GLU LEU ASP LYS SEQRES 44 B 3135 ILE ASP LEU SER TYR GLU THR THR GLU SER GLY ASP THR SEQRES 45 B 3135 ALA VAL SER GLU ASP SER TYR ASP LYS TYR ALA SER ASN SEQRES 46 B 3135 ASN THR ASN LYS GLU TYR VAL CYS ASP PHE THR ASP GLN SEQRES 47 B 3135 LEU LYS PRO THR GLU SER GLY PRO LYS VAL LYS LYS CYS SEQRES 48 B 3135 GLU VAL LYS VAL ASN GLU PRO LEU ILE LYS VAL LYS ILE SEQRES 49 B 3135 ILE CYS PRO LEU LYS GLY SER VAL GLU LYS LEU TYR ASP SEQRES 50 B 3135 ASN ILE GLU TYR VAL PRO LYS LYS SER PRO TYR VAL VAL SEQRES 51 B 3135 LEU THR LYS GLU GLU THR LYS LEU LYS GLU LYS LEU LEU SEQRES 52 B 3135 SER LYS LEU ILE TYR GLY LEU LEU ILE SER PRO THR VAL SEQRES 53 B 3135 ASN GLU LYS GLU ASN ASN PHE LYS GLU GLY VAL ILE GLU SEQRES 54 B 3135 PHE THR LEU PRO PRO VAL VAL HIS LYS ALA THR VAL PHE SEQRES 55 B 3135 TYR PHE ILE CYS ASP ASN SER LYS THR GLU ASP ASP ASN SEQRES 56 B 3135 LYS LYS GLY ASN ARG GLY ILE VAL GLU VAL TYR VAL GLU SEQRES 57 B 3135 PRO TYR GLY ASN LYS ILE ASN GLY CYS ALA PHE LEU ASP SEQRES 58 B 3135 GLU ASP GLU GLU GLU GLU LYS TYR GLY ASN GLN ILE GLU SEQRES 59 B 3135 GLU ASP GLU HIS ASN GLU LYS ILE LYS MET LYS THR PHE SEQRES 60 B 3135 PHE THR GLN ASN ILE TYR LYS LYS ASN ASN ILE TYR PRO SEQRES 61 B 3135 CYS TYR MET LYS LEU TYR SER GLY ASP ILE GLY GLY ILE SEQRES 62 B 3135 LEU PHE PRO LYS ASN ILE LYS SER THR THR CYS PHE GLU SEQRES 63 B 3135 GLU MET ILE PRO TYR ASN LYS GLU ILE LYS TRP ASN LYS SEQRES 64 B 3135 GLU ASN LYS SER LEU GLY ASN LEU VAL ASN ASN SER VAL SEQRES 65 B 3135 VAL TYR ASN LYS GLU MET ASN ALA LYS TYR PHE ASN VAL SEQRES 66 B 3135 GLN TYR VAL HIS ILE PRO THR SER TYR LYS ASP THR LEU SEQRES 67 B 3135 ASN LEU PHE CYS SER ILE ILE LEU LYS GLU GLU GLU SER SEQRES 68 B 3135 ASN LEU ILE SER THR SER TYR LEU VAL TYR VAL SER ILE SEQRES 69 B 3135 ASN GLU GLU LEU ASN PHE SER LEU PHE ASP PHE TYR GLU SEQRES 70 B 3135 SER PHE VAL PRO ILE LYS LYS THR ILE GLN VAL ALA GLN SEQRES 71 B 3135 LYS ASN VAL ASN ASN LYS GLU HIS ASP TYR THR CYS ASP SEQRES 72 B 3135 PHE THR ASP LYS LEU ASP LYS THR VAL PRO SER THR ALA SEQRES 73 B 3135 ASN GLY LYS LYS LEU PHE ILE CYS ARG LYS HIS LEU LYS SEQRES 74 B 3135 GLU PHE ASP THR PHE THR LEU LYS CYS ASN VAL ASN LYS SEQRES 75 B 3135 THR GLN TYR PRO ASN ILE GLU ILE PHE PRO LYS THR LEU SEQRES 76 B 3135 LYS ASP LYS LYS GLU VAL LEU LYS LEU ASP LEU ASP ILE SEQRES 77 B 3135 GLN TYR GLN MET PHE SER LYS PHE PHE LYS PHE ASN THR SEQRES 78 B 3135 GLN ASN ALA LYS TYR LEU ASN LEU TYR PRO TYR TYR LEU SEQRES 79 B 3135 ILE PHE PRO PHE ASN HIS ILE GLY LYS LYS GLU LEU LYS SEQRES 80 B 3135 ASN ASN PRO THR TYR LYS ASN HIS LYS ASP VAL LYS TYR SEQRES 81 B 3135 PHE GLU GLN SER SER VAL LEU SER PRO LEU SER SER ALA SEQRES 82 B 3135 ASP SER LEU GLY LYS LEU LEU ASN PHE LEU ASP THR GLN SEQRES 83 B 3135 GLU THR VAL CYS LEU THR GLU LYS ILE ARG TYR LEU ASN SEQRES 84 B 3135 LEU SER ILE ASN GLU LEU GLY SER ASP ASN ASN THR PHE SEQRES 85 B 3135 SER VAL THR PHE GLN VAL PRO PRO TYR ILE ASP ILE LYS SEQRES 86 B 3135 GLU PRO PHE TYR PHE MET PHE GLY CYS ASN ASN ASN LYS SEQRES 87 B 3135 GLY GLU GLY ASN ILE GLY ILE VAL GLU LEU LEU ILE SER SEQRES 88 B 3135 LYS GLN GLU GLU LYS ILE LYS GLY CYS ASN PHE HIS GLU SEQRES 89 B 3135 SER LYS LEU ASP TYR PHE ASN GLU ASN ILE SER SER ASP SEQRES 90 B 3135 THR HIS GLU CYS THR LEU HIS ALA TYR GLU ASN ASP ILE SEQRES 91 B 3135 ILE GLY PHE ASN CYS LEU GLU THR THR HIS PRO ASN GLU SEQRES 92 B 3135 VAL GLU VAL GLU VAL GLU ASP ALA GLU ILE TYR LEU GLN SEQRES 93 B 3135 PRO GLU ASN CYS PHE ASN ASN VAL TYR LYS GLY LEU ASN SEQRES 94 B 3135 SER VAL ASP ILE THR THR ILE LEU LYS ASN ALA GLN THR SEQRES 95 B 3135 TYR ASN ILE ASN ASN LYS LYS THR PRO THR PHE LEU LYS SEQRES 96 B 3135 ILE PRO PRO TYR ASN LEU LEU GLU ASP VAL GLU ILE SER SEQRES 97 B 3135 CYS GLN CYS THR ILE LYS GLN VAL VAL LYS LYS ILE LYS SEQRES 98 B 3135 VAL ILE ILE THR LYS ASN ASP THR VAL LEU LEU LYS ARG SEQRES 99 B 3135 GLU VAL GLN SER GLU SER THR LEU ASP ASP LYS ILE TYR SEQRES 100 B 3135 LYS CYS GLU HIS GLU ASN PHE ILE ASN PRO ARG VAL ASN SEQRES 101 B 3135 LYS THR PHE ASP GLU ASN VAL GLU TYR THR CYS ASN ILE SEQRES 102 B 3135 LYS ILE GLU ASN PHE PHE ASN TYR ILE GLN ILE PHE CYS SEQRES 103 B 3135 PRO ALA LYS ASP LEU GLY ILE TYR LYS ASN ILE GLN MET SEQRES 104 B 3135 TYR TYR ASP ILE VAL LYS PRO THR ARG VAL PRO GLN PHE SEQRES 105 B 3135 LYS LYS PHE ASN ASN GLU GLU LEU HIS LYS LEU ILE PRO SEQRES 106 B 3135 ASN SER GLU MET LEU HIS LYS THR LYS GLU MET LEU ILE SEQRES 107 B 3135 LEU TYR ASN GLU GLU LYS VAL ASP LEU LEU HIS PHE TYR SEQRES 108 B 3135 VAL PHE LEU PRO ILE TYR ILE LYS ASP ILE TYR GLU PHE SEQRES 109 B 3135 ASN ILE VAL CYS ASP ASN SER LYS THR MET TRP LYS ASN SEQRES 110 B 3135 GLN LEU GLY GLY LYS VAL ILE TYR HIS ILE THR VAL SER SEQRES 111 B 3135 LYS ARG GLU GLN LYS VAL LYS GLY CYS SER PHE ASP ASN SEQRES 112 B 3135 GLU HIS ALA HIS MET PHE SER TYR ASN LYS THR ASN VAL SEQRES 113 B 3135 LYS ASN CYS ILE ILE ASP ALA LYS PRO LYS ASP LEU ILE SEQRES 114 B 3135 GLY PHE VAL CYS PRO SER GLY THR LEU LYS LEU THR ASN SEQRES 115 B 3135 CYS PHE LYS ASP ALA ILE VAL HIS THR ASN LEU THR ASN SEQRES 116 B 3135 ILE ASN GLY ILE LEU TYR LEU LYS ASN ASN LEU ALA ASN SEQRES 117 B 3135 PHE THR TYR LYS HIS GLN PHE ASN TYR MET GLU ILE PRO SEQRES 118 B 3135 ALA LEU MET ASP ASN ASP ILE SER PHE LYS CYS ILE CYS SEQRES 119 B 3135 VAL ASP LEU LYS LYS LYS LYS TYR ASN VAL LYS SER PRO SEQRES 120 B 3135 LEU GLY PRO LYS VAL LEU ARG ALA LEU TYR LYS LYS LEU SEQRES 121 B 3135 ASN ILE LYS PHE ASP ASN TYR VAL THR GLY THR ASP GLN SEQRES 122 B 3135 ASN LYS TYR LEU MET THR TYR MET ASP LEU HIS LEU SER SEQRES 123 B 3135 HIS LYS ARG ASN TYR LEU LYS GLU LEU PHE HIS ASP LEU SEQRES 124 B 3135 GLY LYS LYS LYS PRO ALA ASP THR ASP ALA ASN PRO GLU SEQRES 125 B 3135 SER ILE ILE GLU SER LEU SER ILE ASN GLU SER ASN GLU SEQRES 126 B 3135 SER GLY PRO PHE PRO THR GLY ASP VAL ASP ALA GLU HIS SEQRES 127 B 3135 LEU ILE LEU GLU GLY TYR ASP THR TRP GLU SER LEU TYR SEQRES 128 B 3135 ASP GLU GLN LEU GLU GLU VAL ILE TYR ASN ASP ILE GLU SEQRES 129 B 3135 SER LEU GLU LEU LYS ASP ILE GLU GLN TYR VAL LEU GLN SEQRES 130 B 3135 VAL ASN LEU LYS ALA PRO LYS LEU MET MET SER ALA GLN SEQRES 131 B 3135 ILE HIS ASN ASN ARG HIS VAL CYS ASP PHE SER LYS ASN SEQRES 132 B 3135 ASN LEU ILE VAL PRO GLU SER LEU LYS LYS LYS GLU GLU SEQRES 133 B 3135 LEU GLY GLY ASN PRO VAL ASN ILE HIS CYS TYR ALA LEU SEQRES 134 B 3135 LEU LYS PRO LEU ASP THR LEU TYR VAL LYS CYS PRO THR SEQRES 135 B 3135 SER LYS ASP ASN TYR GLU ALA ALA LYS VAL ASN ILE SER SEQRES 136 B 3135 GLU ASN ASP ASN GLU TYR GLU LEU GLN VAL ILE SER LEU SEQRES 137 B 3135 ILE GLU LYS ARG PHE HIS ASN PHE GLU THR LEU GLU SER SEQRES 138 B 3135 LYS LYS PRO GLY ASN GLY ASP VAL VAL VAL HIS ASN GLY SEQRES 139 B 3135 VAL VAL ASP THR GLY PRO VAL LEU ASP ASN SER THR PHE SEQRES 140 B 3135 GLU LYS TYR PHE LYS ASN ILE LYS ILE LYS PRO ASP LYS SEQRES 141 B 3135 PHE PHE GLU LYS VAL ILE ASN GLU TYR ASP ASP THR GLU SEQRES 142 B 3135 GLU GLU LYS ASP LEU GLU SER ILE LEU PRO GLY ALA ILE SEQRES 143 B 3135 VAL SER PRO MET LYS VAL LEU LYS LYS LYS ASP PRO PHE SEQRES 144 B 3135 THR SER TYR ALA ALA PHE VAL VAL PRO PRO ILE VAL PRO SEQRES 145 B 3135 LYS ASP LEU HIS PHE LYS VAL GLU CYS ASN ASN THR GLU SEQRES 146 B 3135 TYR LYS ASP GLU ASN GLN TYR ILE SER GLY TYR ASN GLY SEQRES 147 B 3135 ILE ILE HIS ILE ASP ILE SER ASN SER ASN ARG LYS ILE SEQRES 148 B 3135 ASN GLY CYS ASP PHE SER THR ASN ASN SER SER ILE LEU SEQRES 149 B 3135 THR SER SER VAL LYS LEU VAL ASN GLY GLU THR LYS ASN SEQRES 150 B 3135 CYS GLU ILE ASN ILE ASN ASN ASN GLU VAL PHE GLY ILE SEQRES 151 B 3135 ILE CYS ASP ASN GLU THR ASN LEU ASP PRO GLU LYS CYS SEQRES 152 B 3135 PHE HIS GLU ILE TYR SER LYS ASP ASN LYS THR VAL LYS SEQRES 153 B 3135 LYS PHE ARG GLU VAL ILE PRO ASN ILE ASP ILE PHE SER SEQRES 154 B 3135 LEU HIS ASN SER ASN LYS LYS LYS VAL ALA TYR ALA LYS SEQRES 155 B 3135 VAL PRO LEU ASP TYR ILE ASN LYS LEU LEU PHE SER CYS SEQRES 156 B 3135 SER CYS LYS THR SER HIS THR ASN THR ILE GLY THR MET SEQRES 157 B 3135 LYS VAL THR LEU ASN LYS ASP GLU LYS GLU GLU GLU ASP SEQRES 158 B 3135 PHE LYS THR ALA GLN GLY ILE LYS HIS ASN ASN VAL HIS SEQRES 159 B 3135 LEU CYS ASN PHE PHE ASP ASN PRO GLU LEU THR PHE ASP SEQRES 160 B 3135 ASN ASN LYS ILE VAL LEU CYS LYS ILE ASP ALA GLU LEU SEQRES 161 B 3135 PHE SER GLU VAL ILE ILE GLN LEU PRO ILE PHE GLY THR SEQRES 162 B 3135 LYS ASN VAL GLU GLU GLY VAL GLN ASN GLU GLU TYR LYS SEQRES 163 B 3135 LYS PHE SER LEU LYS PRO SER LEU VAL PHE ASP ASP ASN SEQRES 164 B 3135 ASN ASN ASP ILE LYS VAL ILE GLY LYS GLU LYS ASN GLU SEQRES 165 B 3135 VAL SER ILE SER LEU ALA LEU LYS GLY VAL TYR GLY ASN SEQRES 166 B 3135 ARG ILE PHE THR PHE ASP LYS ASN GLY LYS LYS GLY GLU SEQRES 167 B 3135 GLY ILE SER PHE PHE ILE PRO PRO ILE LYS GLN ASP THR SEQRES 168 B 3135 ASP LEU LYS PHE ILE ILE ASN GLU THR ILE ASP ASN SER SEQRES 169 B 3135 ASN ILE LYS GLN ARG GLY LEU ILE TYR ILE PHE VAL ARG SEQRES 170 B 3135 LYS ASN VAL SER GLU ASN SER PHE LYS LEU CYS ASP PHE SEQRES 171 B 3135 THR THR GLY SER THR SER LEU MET GLU LEU ASN SER GLN SEQRES 172 B 3135 VAL LYS GLU LYS LYS CYS THR VAL LYS ILE LYS LYS GLY SEQRES 173 B 3135 ASP ILE PHE GLY LEU LYS CYS PRO LYS GLY PHE ALA ILE SEQRES 174 B 3135 PHE PRO GLN ALA CYS PHE SER ASN VAL LEU LEU GLU TYR SEQRES 175 B 3135 TYR LYS SER ASP TYR GLU ASP SER GLU HIS ILE ASN TYR SEQRES 176 B 3135 TYR ILE HIS LYS ASP LYS LYS TYR ASN LEU LYS PRO LYS SEQRES 177 B 3135 ASP VAL ILE GLU LEU MET ASP GLU ASN PHE ARG GLU LEU SEQRES 178 B 3135 GLN ASN ILE GLN GLN TYR THR GLY ILE SER ASN ILE THR SEQRES 179 B 3135 ASP VAL LEU HIS PHE LYS ASN PHE ASN LEU GLY ASN LEU SEQRES 180 B 3135 PRO LEU ASN PHE LYS ASN HIS TYR SER THR ALA TYR ALA SEQRES 181 B 3135 LYS VAL PRO ASP THR PHE ASN SER ILE ILE ASN PHE SER SEQRES 182 B 3135 CYS ASN CYS TYR ASN PRO GLU LYS HIS VAL TYR GLY THR SEQRES 183 B 3135 MET GLN VAL GLU SER ASP ASN ARG ASN PHE ASP ASN ILE SEQRES 184 B 3135 LYS LYS ASN GLU ASN VAL ILE LYS ASN PHE LEU LEU PRO SEQRES 185 B 3135 ASN ILE GLU LYS TYR ALA LEU LEU LEU ASP ASP GLU GLU SEQRES 186 B 3135 ARG GLN LYS LYS ILE LYS GLN GLN GLN GLU GLU GLU GLN SEQRES 187 B 3135 GLN GLU GLN ILE LEU LYS ASP GLN ASP ASP ARG LEU SER SEQRES 188 B 3135 ARG HIS ASP ASP TYR ASN LYS ASN HIS THR TYR ILE LEU SEQRES 189 B 3135 TYR ASP SER ASN GLU HIS ILE CYS ASP TYR GLU LYS ASN SEQRES 190 B 3135 GLU SER LEU ILE SER THR LEU PRO ASN ASP THR LYS LYS SEQRES 191 B 3135 ILE GLN LYS SER ILE CYS LYS ILE ASN ALA LYS ALA LEU SEQRES 192 B 3135 ASP VAL VAL THR ILE LYS CYS PRO HIS THR LYS ASN PHE SEQRES 193 B 3135 THR PRO LYS ASP TYR PHE PRO ASN SER SER LEU ILE THR SEQRES 194 B 3135 ASN ASP LYS LYS ILE VAL ILE THR PHE ASP LYS LYS ASN SEQRES 195 B 3135 PHE VAL THR TYR ILE ASP PRO THR LYS LYS THR PHE SER SEQRES 196 B 3135 LEU LYS ASP ILE TYR ILE GLN SER PHE TYR GLY VAL SER SEQRES 197 B 3135 LEU ASP HIS LEU ASN GLN ILE LYS LYS ILE HIS GLU GLU SEQRES 198 B 3135 TRP ASP ASP VAL HIS LEU PHE TYR PRO PRO HIS ASN VAL SEQRES 199 B 3135 LEU HIS ASN VAL VAL LEU ASN ASN HIS ILE VAL ASN LEU SEQRES 200 B 3135 SER SER ALA LEU GLU GLY VAL LEU PHE MET LYS SER LYS SEQRES 201 B 3135 VAL THR GLY ASP GLU THR ALA THR LYS LYS ASN THR THR SEQRES 202 B 3135 LEU PRO THR ASP GLY VAL SER SER ILE LEU ILE PRO PRO SEQRES 203 B 3135 TYR VAL LYS GLU ASP ILE THR PHE HIS LEU PHE CYS GLY SEQRES 204 B 3135 LYS SER THR THR LYS LYS PRO ASN LYS LYS ASN THR SER SEQRES 205 B 3135 LEU ALA LEU ILE HIS ILE HIS ILE SER SER ASN ARG ASN SEQRES 206 B 3135 ILE ILE HIS GLY CYS ASP PHE LEU TYR LEU GLU ASN GLN SEQRES 207 B 3135 THR ASN ASP ALA ILE SER ASN ASN ASN ASN ASN SER TYR SEQRES 208 B 3135 SER ILE PHE THR HIS ASN LYS ASN THR GLU ASN ASN LEU SEQRES 209 B 3135 ILE CYS ASP ILE SER LEU ILE PRO LYS THR VAL ILE GLY SEQRES 210 B 3135 ILE LYS CYS PRO ASN LYS LYS LEU ASN PRO GLN THR CYS SEQRES 211 B 3135 PHE ASP GLU VAL TYR TYR VAL LYS GLN GLU ASP VAL PRO SEQRES 212 B 3135 SER LYS THR ILE THR ALA ASP LYS TYR ASN THR PHE SER SEQRES 213 B 3135 LYS ASP LYS ILE GLY ASN ILE LEU LYS ASN ALA ILE SER SEQRES 214 B 3135 ILE ASN ASN PRO ASP GLU LYS ASP ASN THR TYR THR TYR SEQRES 215 B 3135 LEU ILE LEU PRO GLU LYS PHE GLU GLU GLU LEU ILE ASP SEQRES 216 B 3135 THR LYS LYS VAL LEU ALA CYS THR CYS ASP ASN LYS TYR SEQRES 217 B 3135 ILE ILE HIS MET LYS ILE GLU LYS SER THR MET ASP LYS SEQRES 218 B 3135 ILE LYS ILE ASP GLU LYS LYS THR ILE GLY LYS ASP ILE SEQRES 219 B 3135 CYS LYS TYR ASP VAL THR THR LYS VAL ALA THR CYS GLU SEQRES 220 B 3135 ILE ILE ASP THR ILE ASP SER SER VAL LEU LYS GLU HIS SEQRES 221 B 3135 HIS THR VAL HIS TYR SER ILE THR LEU SER ARG TRP ASP SEQRES 222 B 3135 LYS LEU ILE ILE LYS TYR PRO THR ASN GLU LYS THR HIS SEQRES 223 B 3135 PHE GLU ASN PHE PHE VAL ASN PRO PHE ASN LEU LYS ASP SEQRES 224 B 3135 LYS VAL LEU TYR ASN TYR ASN LYS PRO ILE ASN ILE GLU SEQRES 225 B 3135 HIS ILE LEU PRO GLY ALA ILE THR THR ASP ILE TYR ASP SEQRES 226 B 3135 THR ARG THR LYS ILE LYS GLN TYR ILE LEU ARG ILE PRO SEQRES 227 B 3135 PRO TYR VAL HIS LYS ASP ILE HIS PHE SER LEU GLU PHE SEQRES 228 B 3135 ASN ASN SER LEU SER LEU THR LYS GLN ASN GLN ASN ILE SEQRES 229 B 3135 ILE TYR GLY ASN VAL ALA LYS ILE PHE ILE HIS ILE ASN SEQRES 230 B 3135 GLN GLY TYR LYS GLU ILE HIS GLY CYS ASP PHE THR GLY SEQRES 231 B 3135 LYS TYR SER HIS LEU PHE THR TYR SER LYS LYS PRO LEU SEQRES 232 B 3135 PRO ASN ASP ASP ASP ILE CYS ASN VAL THR ILE GLY ASN SEQRES 233 B 3135 ASN THR PHE SER GLY PHE ALA CYS LEU SER HIS PHE GLU SEQRES 234 B 3135 LEU LYS PRO ASN ASN CYS PHE SER SER VAL TYR ASP TYR SEQRES 235 B 3135 ASN GLU ALA ASN LYS VAL LYS LYS LEU PHE ASP LEU SER SEQRES 236 B 3135 THR LYS VAL GLU LEU ASP HIS ILE LYS GLN ASN THR SER SEQRES 237 B 3135 GLY TYR THR LEU SER TYR ILE ILE PHE ASN LYS GLU SER SEQRES 238 B 3135 THR LYS LEU LYS PHE SER CYS THR CYS SER SER ASN TYR SEQRES 239 B 3135 SER ASN TYR THR ILE ARG ILE THR PHE ASP PRO ASN TYR SEQRES 240 B 3135 ILE ILE PRO GLU PRO GLN SER ARG ALA ILE ILE LYS TYR SEQRES 241 B 3135 VAL ASP LEU GLN ASP LYS ASN PHE ALA LYS TYR LEU ARG SEQRES 242 B 3135 LYS LEU SEQRES 1 H 221 GLN VAL GLN LEU GLN GLN SER GLY ALA GLU LEU ALA ARG SEQRES 2 H 221 PRO GLY ALA SER VAL LYS LEU SER CYS LYS ALA SER GLY SEQRES 3 H 221 TYR THR PHE THR ASN TYR TRP MET GLN TRP VAL LYS GLN SEQRES 4 H 221 ARG PRO GLY GLN GLY LEU GLU TRP PHE GLY ALA ILE TYR SEQRES 5 H 221 PRO GLY ASP GLY ASP THR ARG TYR THR GLN LYS PHE LYS SEQRES 6 H 221 GLY LYS ALA THR LEU THR ALA ASP LYS SER SER SER THR SEQRES 7 H 221 ALA TYR MET GLN LEU SER SER LEU ALA SER GLU ASP SER SEQRES 8 H 221 ALA VAL TYR TYR CYS ALA ARG SER LEU TYR LEU GLY ALA SEQRES 9 H 221 MET ASP TYR TRP GLY GLN GLY THR SER VAL THR VAL SER SEQRES 10 H 221 SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA SEQRES 11 H 221 PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA LEU SEQRES 12 H 221 GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR SEQRES 13 H 221 VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS SEQRES 14 H 221 THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER SEQRES 15 H 221 LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU GLY SEQRES 16 H 221 THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER SEQRES 17 H 221 ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS SEQRES 1 L 214 ASP ILE VAL MET THR GLN SER HIS LYS PHE MET SER THR SEQRES 2 L 214 SER VAL GLY ASP ARG VAL SER ILE THR CYS LYS ALA SER SEQRES 3 L 214 GLN ASP VAL THR ASN ASP VAL ALA TRP TYR GLN GLN LYS SEQRES 4 L 214 PRO GLY GLN SER PRO LYS LEU LEU ILE TYR SER ALA SER SEQRES 5 L 214 TYR ARG TYR THR GLY VAL PRO ASP ARG PHE THR GLY SER SEQRES 6 L 214 GLY SER GLY THR ASP PHE ILE PHE THR ILE SER SER VAL SEQRES 7 L 214 GLN ALA GLU ASP LEU ALA VAL TYR TYR CYS GLN GLN HIS SEQRES 8 L 214 TYR SER ALA PRO PRO THR PHE GLY GLY GLY THR LYS LEU SEQRES 9 L 214 GLU ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 L 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 L 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 L 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 L 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 L 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 L 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 L 214 PHE ASN ARG GLY GLU CYS HELIX 1 AA1 PRO B 1708 LYS B 1713 1 6 HELIX 2 AA2 SER B 1743 ILE B 1754 1 12 HELIX 3 AA3 ASN B 1759 GLU B 1770 1 12 HELIX 4 AA4 ASN B 1804 PHE B 1811 1 8 HELIX 5 AA5 LEU B 1838 LEU B 1842 1 5 HELIX 6 AA6 THR H 28 TYR H 32 5 5 HELIX 7 AA7 THR H 60 GLY H 65 1 6 HELIX 8 AA8 ALA H 83 SER H 87 5 5 HELIX 9 AA9 GLN L 79 LEU L 83 5 5 SHEET 1 AA1 5 LYS B1684 MET B1687 0 SHEET 2 AA1 5 ILE B1724 LEU B1730 1 O HIS B1725 N LYS B1684 SHEET 3 AA1 5 SER B1894 ILE B1904 1 O ASP B1903 N ALA B1728 SHEET 4 AA1 5 PHE B1877 GLU B1885 -1 N PHE B1877 O ILE B1902 SHEET 5 AA1 5 LYS B1815 ILE B1816 -1 N LYS B1815 O ASN B1882 SHEET 1 AA2 6 LYS B1684 MET B1687 0 SHEET 2 AA2 6 ILE B1724 LEU B1730 1 O HIS B1725 N LYS B1684 SHEET 3 AA2 6 SER B1894 ILE B1904 1 O ASP B1903 N ALA B1728 SHEET 4 AA2 6 PHE B1877 GLU B1885 -1 N PHE B1877 O ILE B1902 SHEET 5 AA2 6 LYS B1824 ASN B1827 -1 N ILE B1826 O LYS B1878 SHEET 6 AA2 6 GLU B1835 ASP B1837 -1 O LYS B1836 N VAL B1825 SHEET 1 AA3 5 ALA B1689 ILE B1691 0 SHEET 2 AA3 5 ARG B1695 ASP B1699 -1 O VAL B1697 N ALA B1689 SHEET 3 AA3 5 THR B1735 PRO B1741 1 O TYR B1737 N HIS B1696 SHEET 4 AA3 5 THR B1860 VAL B1866 -1 O SER B1861 N CYS B1740 SHEET 5 AA3 5 ILE B1846 VAL B1847 -1 N ILE B1846 O VAL B1866 SHEET 1 AA4 5 ALA B1689 ILE B1691 0 SHEET 2 AA4 5 ARG B1695 ASP B1699 -1 O VAL B1697 N ALA B1689 SHEET 3 AA4 5 THR B1735 PRO B1741 1 O TYR B1737 N HIS B1696 SHEET 4 AA4 5 THR B1860 VAL B1866 -1 O SER B1861 N CYS B1740 SHEET 5 AA4 5 LYS B1851 VAL B1852 -1 N LYS B1851 O TYR B1862 SHEET 1 AA5 4 ASN B1937 ILE B1942 0 SHEET 2 AA5 4 THR B2027 LEU B2032 1 O LYS B2029 N ILE B1940 SHEET 3 AA5 4 LEU B2011 THR B2019 -1 N PHE B2013 O VAL B2030 SHEET 4 AA5 4 THR B1956 ASP B1959 -1 N ASN B1957 O LYS B2018 SHEET 1 AA6 2 VAL B1947 ILE B1951 0 SHEET 2 AA6 2 VAL B1998 LYS B2002 -1 O ALA B2001 N PHE B1948 SHEET 1 AA7 2 GLU B1966 SER B1969 0 SHEET 2 AA7 2 THR B1974 LYS B1977 -1 O THR B1974 N SER B1969 SHEET 1 AA8 4 GLN H 3 GLN H 6 0 SHEET 2 AA8 4 VAL H 18 SER H 25 -1 O LYS H 23 N GLN H 5 SHEET 3 AA8 4 THR H 77 LEU H 82 -1 O MET H 80 N LEU H 20 SHEET 4 AA8 4 ALA H 67 ASP H 72 -1 N ASP H 72 O THR H 77 SHEET 1 AA9 6 GLU H 10 ALA H 12 0 SHEET 2 AA9 6 THR H 107 VAL H 111 1 O SER H 108 N GLU H 10 SHEET 3 AA9 6 ALA H 88 SER H 95 -1 N ALA H 88 O VAL H 109 SHEET 4 AA9 6 TRP H 33 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AA9 6 GLU H 46 ILE H 51 -1 O GLU H 46 N LYS H 38 SHEET 6 AA9 6 THR H 57 TYR H 59 -1 O ARG H 58 N ALA H 50 SHEET 1 AB1 4 GLU H 10 ALA H 12 0 SHEET 2 AB1 4 THR H 107 VAL H 111 1 O SER H 108 N GLU H 10 SHEET 3 AB1 4 ALA H 88 SER H 95 -1 N ALA H 88 O VAL H 109 SHEET 4 AB1 4 MET H 100A TRP H 103 -1 O TYR H 102 N ARG H 94 SHEET 1 AB2 4 MET L 4 THR L 5 0 SHEET 2 AB2 4 VAL L 19 ALA L 25 -1 O LYS L 24 N THR L 5 SHEET 3 AB2 4 ASP L 70 ILE L 75 -1 O PHE L 73 N ILE L 21 SHEET 4 AB2 4 PHE L 62 GLY L 66 -1 N THR L 63 O THR L 74 SHEET 1 AB3 6 PHE L 10 SER L 12 0 SHEET 2 AB3 6 THR L 102 GLU L 105 1 O GLU L 105 N MET L 11 SHEET 3 AB3 6 ALA L 84 GLN L 90 -1 N ALA L 84 O LEU L 104 SHEET 4 AB3 6 VAL L 33 GLN L 38 -1 N GLN L 38 O VAL L 85 SHEET 5 AB3 6 LYS L 45 TYR L 49 -1 O LEU L 47 N TRP L 35 SHEET 6 AB3 6 TYR L 53 ARG L 54 -1 O TYR L 53 N TYR L 49 SHEET 1 AB4 4 PHE L 10 SER L 12 0 SHEET 2 AB4 4 THR L 102 GLU L 105 1 O GLU L 105 N MET L 11 SHEET 3 AB4 4 ALA L 84 GLN L 90 -1 N ALA L 84 O LEU L 104 SHEET 4 AB4 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SSBOND 1 CYS B 1698 CYS B 1726 1555 1555 2.03 SSBOND 2 CYS B 1740 CYS B 1881 1555 1555 2.03 SSBOND 3 CYS B 1914 CYS B 1938 1555 1555 2.09 SSBOND 4 CYS B 1952 CYS B 2017 1555 1555 2.03 SSBOND 5 CYS B 1963 CYS B 2015 1555 1555 2.05 SSBOND 6 CYS H 22 CYS H 92 1555 1555 1.99 SSBOND 7 CYS L 23 CYS L 88 1555 1555 1.98 CISPEP 1 ASP B 1959 PRO B 1960 0 9.03 CISPEP 2 CYS B 1963 PHE B 1964 0 12.18 CISPEP 3 ALA L 94 PRO L 95 0 -1.46 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000