HEADER VIRAL PROTEIN 27-FEB-25 9NJL TITLE MARV GP IN COMPLEX WITH MARV16 FAB COMPND MOL_ID: 1; COMPND 2 MOLECULE: MARV16 HEAVY CHAIN; COMPND 3 CHAIN: H, I, J; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: MARV16 LIGHT CHAIN; COMPND 7 CHAIN: L, N, P; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: ENVELOPE GLYCOPROTEIN GP1; COMPND 11 CHAIN: A, C, E; COMPND 12 SYNONYM: GP1,2,GP,VIRION SPIKE GLYCOPROTEIN; COMPND 13 ENGINEERED: YES; COMPND 14 MOL_ID: 4; COMPND 15 MOLECULE: ENVELOPE GLYCOPROTEIN GP2; COMPND 16 CHAIN: B, D, F; COMPND 17 ENGINEERED: YES; COMPND 18 MUTATION: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 3 ORGANISM_COMMON: MOUSE; SOURCE 4 ORGANISM_TAXID: 10090; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 10 ORGANISM_COMMON: MOUSE; SOURCE 11 ORGANISM_TAXID: 10090; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: ORTHOMARBURGVIRUS MARBURGENSE; SOURCE 17 ORGANISM_TAXID: 3052505; SOURCE 18 STRAIN: MUSOKE; SOURCE 19 GENE: GP; SOURCE 20 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 21 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 23 MOL_ID: 4; SOURCE 24 ORGANISM_SCIENTIFIC: ORTHOMARBURGVIRUS MARBURGENSE; SOURCE 25 ORGANISM_TAXID: 3052505; SOURCE 26 STRAIN: MUSOKE; SOURCE 27 GENE: GP; SOURCE 28 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 29 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 30 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS GLYCOPROTEIN, ANTIBODY, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL KEYWDS 2 GENOMICS CENTER FOR INFECTIOUS DISEASE, SSGCID, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR A.ADDETIA,SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE AUTHOR 2 (SSGCID),D.VEESLER REVDAT 1 26-NOV-25 9NJL 0 JRNL AUTH A.ADDETIA,L.PERRUZZA,K.SPROUSE,Y.J.PARK,M.MCCALLUM, JRNL AUTH 2 C.STEWART,B.PARTINI,J.T.BROWN,A.DONATI,K.CULAP,A.BALMELLI, JRNL AUTH 3 B.CHAWLA,S.KAR,M.GAZI,K.ALFSON,Y.GOEZ-GAZI,R.CARRION JR., JRNL AUTH 4 D.CORTI,F.BENIGNI,D.VEESLER JRNL TITL POTENT NEUTRALIZATION OF MARBURG VIRUS BY A VACCINE-ELICITED JRNL TITL 2 ANTIBODY. JRNL REF NATURE 2025 JRNL REFN ESSN 1476-4687 JRNL PMID 41225006 JRNL DOI 10.1038/S41586-025-09868-1 REMARK 2 REMARK 2 RESOLUTION. 2.60 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : WARP, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.600 REMARK 3 NUMBER OF PARTICLES : 368509 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9NJL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-FEB-25. REMARK 100 THE DEPOSITION ID IS D_1000293498. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : MARV GP IN COMPLEX WITH MARV16 REMARK 245 FAB REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 400.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6300.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, A, B, I, N, C, D, J, P, REMARK 350 AND CHAINS: E, F, G, K, M, O, Q, R REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 SER H 120 REMARK 465 ALA H 121 REMARK 465 SER H 122 REMARK 465 THR H 123 REMARK 465 LYS H 124 REMARK 465 GLY H 125 REMARK 465 PRO H 126 REMARK 465 SER H 127 REMARK 465 VAL H 128 REMARK 465 PHE H 129 REMARK 465 PRO H 130 REMARK 465 LEU H 131 REMARK 465 ALA H 132 REMARK 465 PRO H 133 REMARK 465 SER H 134 REMARK 465 SER H 135 REMARK 465 LYS H 136 REMARK 465 SER H 137 REMARK 465 THR H 138 REMARK 465 SER H 139 REMARK 465 GLY H 140 REMARK 465 GLY H 141 REMARK 465 THR H 142 REMARK 465 ALA H 143 REMARK 465 ALA H 144 REMARK 465 LEU H 145 REMARK 465 GLY H 146 REMARK 465 CYS H 147 REMARK 465 LEU H 148 REMARK 465 VAL H 149 REMARK 465 LYS H 150 REMARK 465 ASP H 151 REMARK 465 TYR H 152 REMARK 465 PHE H 153 REMARK 465 PRO H 154 REMARK 465 GLU H 155 REMARK 465 PRO H 156 REMARK 465 VAL H 157 REMARK 465 THR H 158 REMARK 465 VAL H 159 REMARK 465 SER H 160 REMARK 465 TRP H 161 REMARK 465 ASN H 162 REMARK 465 SER H 163 REMARK 465 GLY H 164 REMARK 465 ALA H 165 REMARK 465 LEU H 166 REMARK 465 THR H 167 REMARK 465 SER H 168 REMARK 465 GLY H 169 REMARK 465 VAL H 170 REMARK 465 HIS H 171 REMARK 465 THR H 172 REMARK 465 PHE H 173 REMARK 465 PRO H 174 REMARK 465 ALA H 175 REMARK 465 VAL H 176 REMARK 465 LEU H 177 REMARK 465 GLN H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 GLY H 181 REMARK 465 LEU H 182 REMARK 465 TYR H 183 REMARK 465 SER H 184 REMARK 465 LEU H 185 REMARK 465 SER H 186 REMARK 465 SER H 187 REMARK 465 VAL H 188 REMARK 465 VAL H 189 REMARK 465 THR H 190 REMARK 465 VAL H 191 REMARK 465 PRO H 192 REMARK 465 SER H 193 REMARK 465 SER H 194 REMARK 465 SER H 195 REMARK 465 LEU H 196 REMARK 465 GLY H 197 REMARK 465 THR H 198 REMARK 465 GLN H 199 REMARK 465 THR H 200 REMARK 465 TYR H 201 REMARK 465 ILE H 202 REMARK 465 CYS H 203 REMARK 465 ASN H 204 REMARK 465 VAL H 205 REMARK 465 ASN H 206 REMARK 465 HIS H 207 REMARK 465 LYS H 208 REMARK 465 PRO H 209 REMARK 465 SER H 210 REMARK 465 ASN H 211 REMARK 465 THR H 212 REMARK 465 LYS H 213 REMARK 465 VAL H 214 REMARK 465 ASP H 215 REMARK 465 LYS H 216 REMARK 465 ARG H 217 REMARK 465 VAL H 218 REMARK 465 GLU H 219 REMARK 465 PRO H 220 REMARK 465 LYS H 221 REMARK 465 SER H 222 REMARK 465 CYS H 223 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 MET A 1 REMARK 465 LYS A 2 REMARK 465 THR A 3 REMARK 465 THR A 4 REMARK 465 CYS A 5 REMARK 465 PHE A 6 REMARK 465 LEU A 7 REMARK 465 ILE A 8 REMARK 465 SER A 9 REMARK 465 LEU A 10 REMARK 465 ILE A 11 REMARK 465 LEU A 12 REMARK 465 ILE A 13 REMARK 465 GLN A 14 REMARK 465 GLY A 15 REMARK 465 THR A 16 REMARK 465 LYS A 17 REMARK 465 ASN A 18 REMARK 465 LEU A 19 REMARK 465 PRO A 20 REMARK 465 ILE A 21 REMARK 465 LEU A 22 REMARK 465 GLU A 23 REMARK 465 ILE A 24 REMARK 465 ALA A 25 REMARK 465 SER A 26 REMARK 465 ASN A 27 REMARK 465 ASN A 28 REMARK 465 GLN A 29 REMARK 465 PRO A 30 REMARK 465 GLN A 31 REMARK 465 ASN A 32 REMARK 465 VAL A 33 REMARK 465 ASP A 34 REMARK 465 SER A 35 REMARK 465 VAL A 36 REMARK 465 CYS A 37 REMARK 465 SER A 38 REMARK 465 GLN A 182 REMARK 465 GLY A 183 REMARK 465 GLN A 184 REMARK 465 GLY A 185 REMARK 465 TYR A 186 REMARK 465 ARG A 187 REMARK 465 HIS A 188 REMARK 465 MET A 189 REMARK 465 ASN A 190 REMARK 465 SER A 220 REMARK 465 THR A 221 REMARK 465 LYS A 222 REMARK 465 ASN A 223 REMARK 465 GLN A 224 REMARK 465 THR A 225 REMARK 465 CYS A 226 REMARK 465 ALA A 227 REMARK 465 PRO A 228 REMARK 465 SER A 229 REMARK 465 LYS A 230 REMARK 465 ILE A 231 REMARK 465 PRO A 232 REMARK 465 PRO A 233 REMARK 465 PRO A 234 REMARK 465 LEU A 235 REMARK 465 PRO A 236 REMARK 465 THR A 237 REMARK 465 ALA A 238 REMARK 465 ARG A 239 REMARK 465 PRO A 240 REMARK 465 GLU A 241 REMARK 465 ILE A 242 REMARK 465 LYS A 243 REMARK 465 LEU A 244 REMARK 465 THR A 245 REMARK 465 SER A 246 REMARK 465 THR A 247 REMARK 465 PRO A 248 REMARK 465 THR A 249 REMARK 465 ASP A 250 REMARK 465 ALA A 251 REMARK 465 THR A 252 REMARK 465 LYS A 253 REMARK 465 LEU A 254 REMARK 465 ASN A 255 REMARK 465 THR A 256 REMARK 465 GLN A 257 REMARK 465 HIS A 258 REMARK 465 LEU A 259 REMARK 465 VAL A 260 REMARK 465 TYR A 261 REMARK 465 PHE A 262 REMARK 465 ARG A 263 REMARK 465 ARG A 264 REMARK 465 LYS A 265 REMARK 465 ARG A 266 REMARK 465 SER B 436 REMARK 465 ILE B 437 REMARK 465 LEU B 438 REMARK 465 ALA B 439 REMARK 465 ARG B 440 REMARK 465 GLU B 441 REMARK 465 GLY B 442 REMARK 465 ASP B 443 REMARK 465 MET B 444 REMARK 465 GLY B 445 REMARK 465 PRO B 446 REMARK 465 ASN B 447 REMARK 465 LEU B 448 REMARK 465 ASP B 449 REMARK 465 GLY B 450 REMARK 465 LEU B 451 REMARK 465 ILE B 452 REMARK 465 ASN B 453 REMARK 465 ALA B 454 REMARK 465 PRO B 455 REMARK 465 ILE B 456 REMARK 465 ASP B 457 REMARK 465 PHE B 458 REMARK 465 ASP B 459 REMARK 465 PRO B 460 REMARK 465 VAL B 461 REMARK 465 PRO B 462 REMARK 465 ASN B 463 REMARK 465 THR B 464 REMARK 465 LYS B 465 REMARK 465 THR B 466 REMARK 465 ILE B 467 REMARK 465 PHE B 468 REMARK 465 ASP B 469 REMARK 465 GLU B 470 REMARK 465 SER B 471 REMARK 465 SER B 472 REMARK 465 SER B 473 REMARK 465 SER B 474 REMARK 465 GLY B 475 REMARK 465 ALA B 476 REMARK 465 SER B 477 REMARK 465 ALA B 478 REMARK 465 GLU B 479 REMARK 465 GLU B 480 REMARK 465 ASP B 481 REMARK 465 GLN B 482 REMARK 465 HIS B 483 REMARK 465 ALA B 484 REMARK 465 SER B 485 REMARK 465 PRO B 486 REMARK 465 ASN B 487 REMARK 465 ILE B 488 REMARK 465 SER B 489 REMARK 465 LEU B 490 REMARK 465 THR B 491 REMARK 465 LEU B 492 REMARK 465 SER B 493 REMARK 465 TYR B 494 REMARK 465 PHE B 495 REMARK 465 PRO B 496 REMARK 465 ASN B 497 REMARK 465 ILE B 498 REMARK 465 ASN B 499 REMARK 465 GLU B 500 REMARK 465 ASN B 501 REMARK 465 THR B 502 REMARK 465 VAL B 521 REMARK 465 GLN B 522 REMARK 465 GLU B 523 REMARK 465 ASP B 524 REMARK 465 ASP B 525 REMARK 465 LEU B 526 REMARK 465 ALA B 527 REMARK 465 ALA B 528 REMARK 465 TRP B 598 REMARK 465 GLY B 599 REMARK 465 GLY B 600 REMARK 465 THR B 601 REMARK 465 CYS B 602 REMARK 465 LYS B 603 REMARK 465 VAL B 604 REMARK 465 LEU B 605 REMARK 465 GLY B 606 REMARK 465 PRO B 607 REMARK 465 ASP B 608 REMARK 465 CYS B 609 REMARK 465 CYS B 610 REMARK 465 ILE B 611 REMARK 465 GLY B 612 REMARK 465 ILE B 613 REMARK 465 GLU B 614 REMARK 465 ASP B 615 REMARK 465 LEU B 616 REMARK 465 SER B 617 REMARK 465 LYS B 618 REMARK 465 ASN B 619 REMARK 465 ILE B 620 REMARK 465 SER B 621 REMARK 465 GLU B 622 REMARK 465 GLN B 623 REMARK 465 ILE B 624 REMARK 465 ASP B 625 REMARK 465 GLN B 626 REMARK 465 ILE B 627 REMARK 465 LYS B 628 REMARK 465 LYS B 629 REMARK 465 ASP B 630 REMARK 465 GLU B 631 REMARK 465 GLN B 632 REMARK 465 LYS B 633 REMARK 465 GLU B 634 REMARK 465 GLY B 635 REMARK 465 THR B 636 REMARK 465 GLY B 637 REMARK 465 SER B 638 REMARK 465 HIS B 639 REMARK 465 HIS B 640 REMARK 465 HIS B 641 REMARK 465 HIS B 642 REMARK 465 HIS B 643 REMARK 465 HIS B 644 REMARK 465 HIS B 645 REMARK 465 HIS B 646 REMARK 465 SER I 120 REMARK 465 ALA I 121 REMARK 465 SER I 122 REMARK 465 THR I 123 REMARK 465 LYS I 124 REMARK 465 GLY I 125 REMARK 465 PRO I 126 REMARK 465 SER I 127 REMARK 465 VAL I 128 REMARK 465 PHE I 129 REMARK 465 PRO I 130 REMARK 465 LEU I 131 REMARK 465 ALA I 132 REMARK 465 PRO I 133 REMARK 465 SER I 134 REMARK 465 SER I 135 REMARK 465 LYS I 136 REMARK 465 SER I 137 REMARK 465 THR I 138 REMARK 465 SER I 139 REMARK 465 GLY I 140 REMARK 465 GLY I 141 REMARK 465 THR I 142 REMARK 465 ALA I 143 REMARK 465 ALA I 144 REMARK 465 LEU I 145 REMARK 465 GLY I 146 REMARK 465 CYS I 147 REMARK 465 LEU I 148 REMARK 465 VAL I 149 REMARK 465 LYS I 150 REMARK 465 ASP I 151 REMARK 465 TYR I 152 REMARK 465 PHE I 153 REMARK 465 PRO I 154 REMARK 465 GLU I 155 REMARK 465 PRO I 156 REMARK 465 VAL I 157 REMARK 465 THR I 158 REMARK 465 VAL I 159 REMARK 465 SER I 160 REMARK 465 TRP I 161 REMARK 465 ASN I 162 REMARK 465 SER I 163 REMARK 465 GLY I 164 REMARK 465 ALA I 165 REMARK 465 LEU I 166 REMARK 465 THR I 167 REMARK 465 SER I 168 REMARK 465 GLY I 169 REMARK 465 VAL I 170 REMARK 465 HIS I 171 REMARK 465 THR I 172 REMARK 465 PHE I 173 REMARK 465 PRO I 174 REMARK 465 ALA I 175 REMARK 465 VAL I 176 REMARK 465 LEU I 177 REMARK 465 GLN I 178 REMARK 465 SER I 179 REMARK 465 SER I 180 REMARK 465 GLY I 181 REMARK 465 LEU I 182 REMARK 465 TYR I 183 REMARK 465 SER I 184 REMARK 465 LEU I 185 REMARK 465 SER I 186 REMARK 465 SER I 187 REMARK 465 VAL I 188 REMARK 465 VAL I 189 REMARK 465 THR I 190 REMARK 465 VAL I 191 REMARK 465 PRO I 192 REMARK 465 SER I 193 REMARK 465 SER I 194 REMARK 465 SER I 195 REMARK 465 LEU I 196 REMARK 465 GLY I 197 REMARK 465 THR I 198 REMARK 465 GLN I 199 REMARK 465 THR I 200 REMARK 465 TYR I 201 REMARK 465 ILE I 202 REMARK 465 CYS I 203 REMARK 465 ASN I 204 REMARK 465 VAL I 205 REMARK 465 ASN I 206 REMARK 465 HIS I 207 REMARK 465 LYS I 208 REMARK 465 PRO I 209 REMARK 465 SER I 210 REMARK 465 ASN I 211 REMARK 465 THR I 212 REMARK 465 LYS I 213 REMARK 465 VAL I 214 REMARK 465 ASP I 215 REMARK 465 LYS I 216 REMARK 465 ARG I 217 REMARK 465 VAL I 218 REMARK 465 GLU I 219 REMARK 465 PRO I 220 REMARK 465 LYS I 221 REMARK 465 SER I 222 REMARK 465 CYS I 223 REMARK 465 ARG N 108 REMARK 465 THR N 109 REMARK 465 VAL N 110 REMARK 465 ALA N 111 REMARK 465 ALA N 112 REMARK 465 PRO N 113 REMARK 465 SER N 114 REMARK 465 VAL N 115 REMARK 465 PHE N 116 REMARK 465 ILE N 117 REMARK 465 PHE N 118 REMARK 465 PRO N 119 REMARK 465 PRO N 120 REMARK 465 SER N 121 REMARK 465 ASP N 122 REMARK 465 GLU N 123 REMARK 465 GLN N 124 REMARK 465 LEU N 125 REMARK 465 LYS N 126 REMARK 465 SER N 127 REMARK 465 GLY N 128 REMARK 465 THR N 129 REMARK 465 ALA N 130 REMARK 465 SER N 131 REMARK 465 VAL N 132 REMARK 465 VAL N 133 REMARK 465 CYS N 134 REMARK 465 LEU N 135 REMARK 465 LEU N 136 REMARK 465 ASN N 137 REMARK 465 ASN N 138 REMARK 465 PHE N 139 REMARK 465 TYR N 140 REMARK 465 PRO N 141 REMARK 465 ARG N 142 REMARK 465 GLU N 143 REMARK 465 ALA N 144 REMARK 465 LYS N 145 REMARK 465 VAL N 146 REMARK 465 GLN N 147 REMARK 465 TRP N 148 REMARK 465 LYS N 149 REMARK 465 VAL N 150 REMARK 465 ASP N 151 REMARK 465 ASN N 152 REMARK 465 ALA N 153 REMARK 465 LEU N 154 REMARK 465 GLN N 155 REMARK 465 SER N 156 REMARK 465 GLY N 157 REMARK 465 ASN N 158 REMARK 465 SER N 159 REMARK 465 GLN N 160 REMARK 465 GLU N 161 REMARK 465 SER N 162 REMARK 465 VAL N 163 REMARK 465 THR N 164 REMARK 465 GLU N 165 REMARK 465 GLN N 166 REMARK 465 ASP N 167 REMARK 465 SER N 168 REMARK 465 LYS N 169 REMARK 465 ASP N 170 REMARK 465 SER N 171 REMARK 465 THR N 172 REMARK 465 TYR N 173 REMARK 465 SER N 174 REMARK 465 LEU N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 THR N 178 REMARK 465 LEU N 179 REMARK 465 THR N 180 REMARK 465 LEU N 181 REMARK 465 SER N 182 REMARK 465 LYS N 183 REMARK 465 ALA N 184 REMARK 465 ASP N 185 REMARK 465 TYR N 186 REMARK 465 GLU N 187 REMARK 465 LYS N 188 REMARK 465 HIS N 189 REMARK 465 LYS N 190 REMARK 465 VAL N 191 REMARK 465 TYR N 192 REMARK 465 ALA N 193 REMARK 465 CYS N 194 REMARK 465 GLU N 195 REMARK 465 VAL N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 GLN N 199 REMARK 465 GLY N 200 REMARK 465 LEU N 201 REMARK 465 SER N 202 REMARK 465 SER N 203 REMARK 465 PRO N 204 REMARK 465 VAL N 205 REMARK 465 THR N 206 REMARK 465 LYS N 207 REMARK 465 SER N 208 REMARK 465 PHE N 209 REMARK 465 ASN N 210 REMARK 465 ARG N 211 REMARK 465 GLY N 212 REMARK 465 GLU N 213 REMARK 465 CYS N 214 REMARK 465 MET C 1 REMARK 465 LYS C 2 REMARK 465 THR C 3 REMARK 465 THR C 4 REMARK 465 CYS C 5 REMARK 465 PHE C 6 REMARK 465 LEU C 7 REMARK 465 ILE C 8 REMARK 465 SER C 9 REMARK 465 LEU C 10 REMARK 465 ILE C 11 REMARK 465 LEU C 12 REMARK 465 ILE C 13 REMARK 465 GLN C 14 REMARK 465 GLY C 15 REMARK 465 THR C 16 REMARK 465 LYS C 17 REMARK 465 ASN C 18 REMARK 465 LEU C 19 REMARK 465 PRO C 20 REMARK 465 ILE C 21 REMARK 465 LEU C 22 REMARK 465 GLU C 23 REMARK 465 ILE C 24 REMARK 465 ALA C 25 REMARK 465 SER C 26 REMARK 465 ASN C 27 REMARK 465 ASN C 28 REMARK 465 GLN C 29 REMARK 465 PRO C 30 REMARK 465 GLN C 31 REMARK 465 ASN C 32 REMARK 465 VAL C 33 REMARK 465 ASP C 34 REMARK 465 SER C 35 REMARK 465 VAL C 36 REMARK 465 CYS C 37 REMARK 465 SER C 38 REMARK 465 GLN C 182 REMARK 465 GLY C 183 REMARK 465 GLN C 184 REMARK 465 GLY C 185 REMARK 465 TYR C 186 REMARK 465 ARG C 187 REMARK 465 HIS C 188 REMARK 465 MET C 189 REMARK 465 ASN C 190 REMARK 465 SER C 220 REMARK 465 THR C 221 REMARK 465 LYS C 222 REMARK 465 ASN C 223 REMARK 465 GLN C 224 REMARK 465 THR C 225 REMARK 465 CYS C 226 REMARK 465 ALA C 227 REMARK 465 PRO C 228 REMARK 465 SER C 229 REMARK 465 LYS C 230 REMARK 465 ILE C 231 REMARK 465 PRO C 232 REMARK 465 PRO C 233 REMARK 465 PRO C 234 REMARK 465 LEU C 235 REMARK 465 PRO C 236 REMARK 465 THR C 237 REMARK 465 ALA C 238 REMARK 465 ARG C 239 REMARK 465 PRO C 240 REMARK 465 GLU C 241 REMARK 465 ILE C 242 REMARK 465 LYS C 243 REMARK 465 LEU C 244 REMARK 465 THR C 245 REMARK 465 SER C 246 REMARK 465 THR C 247 REMARK 465 PRO C 248 REMARK 465 THR C 249 REMARK 465 ASP C 250 REMARK 465 ALA C 251 REMARK 465 THR C 252 REMARK 465 LYS C 253 REMARK 465 LEU C 254 REMARK 465 ASN C 255 REMARK 465 THR C 256 REMARK 465 GLN C 257 REMARK 465 HIS C 258 REMARK 465 LEU C 259 REMARK 465 VAL C 260 REMARK 465 TYR C 261 REMARK 465 PHE C 262 REMARK 465 ARG C 263 REMARK 465 ARG C 264 REMARK 465 LYS C 265 REMARK 465 ARG C 266 REMARK 465 SER D 436 REMARK 465 ILE D 437 REMARK 465 LEU D 438 REMARK 465 ALA D 439 REMARK 465 ARG D 440 REMARK 465 GLU D 441 REMARK 465 GLY D 442 REMARK 465 ASP D 443 REMARK 465 MET D 444 REMARK 465 GLY D 445 REMARK 465 PRO D 446 REMARK 465 ASN D 447 REMARK 465 LEU D 448 REMARK 465 ASP D 449 REMARK 465 GLY D 450 REMARK 465 LEU D 451 REMARK 465 ILE D 452 REMARK 465 ASN D 453 REMARK 465 ALA D 454 REMARK 465 PRO D 455 REMARK 465 ILE D 456 REMARK 465 ASP D 457 REMARK 465 PHE D 458 REMARK 465 ASP D 459 REMARK 465 PRO D 460 REMARK 465 VAL D 461 REMARK 465 PRO D 462 REMARK 465 ASN D 463 REMARK 465 THR D 464 REMARK 465 LYS D 465 REMARK 465 THR D 466 REMARK 465 ILE D 467 REMARK 465 PHE D 468 REMARK 465 ASP D 469 REMARK 465 GLU D 470 REMARK 465 SER D 471 REMARK 465 SER D 472 REMARK 465 SER D 473 REMARK 465 SER D 474 REMARK 465 GLY D 475 REMARK 465 ALA D 476 REMARK 465 SER D 477 REMARK 465 ALA D 478 REMARK 465 GLU D 479 REMARK 465 GLU D 480 REMARK 465 ASP D 481 REMARK 465 GLN D 482 REMARK 465 HIS D 483 REMARK 465 ALA D 484 REMARK 465 SER D 485 REMARK 465 PRO D 486 REMARK 465 ASN D 487 REMARK 465 ILE D 488 REMARK 465 SER D 489 REMARK 465 LEU D 490 REMARK 465 THR D 491 REMARK 465 LEU D 492 REMARK 465 SER D 493 REMARK 465 TYR D 494 REMARK 465 PHE D 495 REMARK 465 PRO D 496 REMARK 465 ASN D 497 REMARK 465 ILE D 498 REMARK 465 ASN D 499 REMARK 465 GLU D 500 REMARK 465 ASN D 501 REMARK 465 THR D 502 REMARK 465 VAL D 521 REMARK 465 GLN D 522 REMARK 465 GLU D 523 REMARK 465 ASP D 524 REMARK 465 ASP D 525 REMARK 465 LEU D 526 REMARK 465 ALA D 527 REMARK 465 ALA D 528 REMARK 465 TRP D 598 REMARK 465 GLY D 599 REMARK 465 GLY D 600 REMARK 465 THR D 601 REMARK 465 CYS D 602 REMARK 465 LYS D 603 REMARK 465 VAL D 604 REMARK 465 LEU D 605 REMARK 465 GLY D 606 REMARK 465 PRO D 607 REMARK 465 ASP D 608 REMARK 465 CYS D 609 REMARK 465 CYS D 610 REMARK 465 ILE D 611 REMARK 465 GLY D 612 REMARK 465 ILE D 613 REMARK 465 GLU D 614 REMARK 465 ASP D 615 REMARK 465 LEU D 616 REMARK 465 SER D 617 REMARK 465 LYS D 618 REMARK 465 ASN D 619 REMARK 465 ILE D 620 REMARK 465 SER D 621 REMARK 465 GLU D 622 REMARK 465 GLN D 623 REMARK 465 ILE D 624 REMARK 465 ASP D 625 REMARK 465 GLN D 626 REMARK 465 ILE D 627 REMARK 465 LYS D 628 REMARK 465 LYS D 629 REMARK 465 ASP D 630 REMARK 465 GLU D 631 REMARK 465 GLN D 632 REMARK 465 LYS D 633 REMARK 465 GLU D 634 REMARK 465 GLY D 635 REMARK 465 THR D 636 REMARK 465 GLY D 637 REMARK 465 SER D 638 REMARK 465 HIS D 639 REMARK 465 HIS D 640 REMARK 465 HIS D 641 REMARK 465 HIS D 642 REMARK 465 HIS D 643 REMARK 465 HIS D 644 REMARK 465 HIS D 645 REMARK 465 HIS D 646 REMARK 465 SER J 120 REMARK 465 ALA J 121 REMARK 465 SER J 122 REMARK 465 THR J 123 REMARK 465 LYS J 124 REMARK 465 GLY J 125 REMARK 465 PRO J 126 REMARK 465 SER J 127 REMARK 465 VAL J 128 REMARK 465 PHE J 129 REMARK 465 PRO J 130 REMARK 465 LEU J 131 REMARK 465 ALA J 132 REMARK 465 PRO J 133 REMARK 465 SER J 134 REMARK 465 SER J 135 REMARK 465 LYS J 136 REMARK 465 SER J 137 REMARK 465 THR J 138 REMARK 465 SER J 139 REMARK 465 GLY J 140 REMARK 465 GLY J 141 REMARK 465 THR J 142 REMARK 465 ALA J 143 REMARK 465 ALA J 144 REMARK 465 LEU J 145 REMARK 465 GLY J 146 REMARK 465 CYS J 147 REMARK 465 LEU J 148 REMARK 465 VAL J 149 REMARK 465 LYS J 150 REMARK 465 ASP J 151 REMARK 465 TYR J 152 REMARK 465 PHE J 153 REMARK 465 PRO J 154 REMARK 465 GLU J 155 REMARK 465 PRO J 156 REMARK 465 VAL J 157 REMARK 465 THR J 158 REMARK 465 VAL J 159 REMARK 465 SER J 160 REMARK 465 TRP J 161 REMARK 465 ASN J 162 REMARK 465 SER J 163 REMARK 465 GLY J 164 REMARK 465 ALA J 165 REMARK 465 LEU J 166 REMARK 465 THR J 167 REMARK 465 SER J 168 REMARK 465 GLY J 169 REMARK 465 VAL J 170 REMARK 465 HIS J 171 REMARK 465 THR J 172 REMARK 465 PHE J 173 REMARK 465 PRO J 174 REMARK 465 ALA J 175 REMARK 465 VAL J 176 REMARK 465 LEU J 177 REMARK 465 GLN J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 GLY J 181 REMARK 465 LEU J 182 REMARK 465 TYR J 183 REMARK 465 SER J 184 REMARK 465 LEU J 185 REMARK 465 SER J 186 REMARK 465 SER J 187 REMARK 465 VAL J 188 REMARK 465 VAL J 189 REMARK 465 THR J 190 REMARK 465 VAL J 191 REMARK 465 PRO J 192 REMARK 465 SER J 193 REMARK 465 SER J 194 REMARK 465 SER J 195 REMARK 465 LEU J 196 REMARK 465 GLY J 197 REMARK 465 THR J 198 REMARK 465 GLN J 199 REMARK 465 THR J 200 REMARK 465 TYR J 201 REMARK 465 ILE J 202 REMARK 465 CYS J 203 REMARK 465 ASN J 204 REMARK 465 VAL J 205 REMARK 465 ASN J 206 REMARK 465 HIS J 207 REMARK 465 LYS J 208 REMARK 465 PRO J 209 REMARK 465 SER J 210 REMARK 465 ASN J 211 REMARK 465 THR J 212 REMARK 465 LYS J 213 REMARK 465 VAL J 214 REMARK 465 ASP J 215 REMARK 465 LYS J 216 REMARK 465 ARG J 217 REMARK 465 VAL J 218 REMARK 465 GLU J 219 REMARK 465 PRO J 220 REMARK 465 LYS J 221 REMARK 465 SER J 222 REMARK 465 CYS J 223 REMARK 465 ARG P 108 REMARK 465 THR P 109 REMARK 465 VAL P 110 REMARK 465 ALA P 111 REMARK 465 ALA P 112 REMARK 465 PRO P 113 REMARK 465 SER P 114 REMARK 465 VAL P 115 REMARK 465 PHE P 116 REMARK 465 ILE P 117 REMARK 465 PHE P 118 REMARK 465 PRO P 119 REMARK 465 PRO P 120 REMARK 465 SER P 121 REMARK 465 ASP P 122 REMARK 465 GLU P 123 REMARK 465 GLN P 124 REMARK 465 LEU P 125 REMARK 465 LYS P 126 REMARK 465 SER P 127 REMARK 465 GLY P 128 REMARK 465 THR P 129 REMARK 465 ALA P 130 REMARK 465 SER P 131 REMARK 465 VAL P 132 REMARK 465 VAL P 133 REMARK 465 CYS P 134 REMARK 465 LEU P 135 REMARK 465 LEU P 136 REMARK 465 ASN P 137 REMARK 465 ASN P 138 REMARK 465 PHE P 139 REMARK 465 TYR P 140 REMARK 465 PRO P 141 REMARK 465 ARG P 142 REMARK 465 GLU P 143 REMARK 465 ALA P 144 REMARK 465 LYS P 145 REMARK 465 VAL P 146 REMARK 465 GLN P 147 REMARK 465 TRP P 148 REMARK 465 LYS P 149 REMARK 465 VAL P 150 REMARK 465 ASP P 151 REMARK 465 ASN P 152 REMARK 465 ALA P 153 REMARK 465 LEU P 154 REMARK 465 GLN P 155 REMARK 465 SER P 156 REMARK 465 GLY P 157 REMARK 465 ASN P 158 REMARK 465 SER P 159 REMARK 465 GLN P 160 REMARK 465 GLU P 161 REMARK 465 SER P 162 REMARK 465 VAL P 163 REMARK 465 THR P 164 REMARK 465 GLU P 165 REMARK 465 GLN P 166 REMARK 465 ASP P 167 REMARK 465 SER P 168 REMARK 465 LYS P 169 REMARK 465 ASP P 170 REMARK 465 SER P 171 REMARK 465 THR P 172 REMARK 465 TYR P 173 REMARK 465 SER P 174 REMARK 465 LEU P 175 REMARK 465 SER P 176 REMARK 465 SER P 177 REMARK 465 THR P 178 REMARK 465 LEU P 179 REMARK 465 THR P 180 REMARK 465 LEU P 181 REMARK 465 SER P 182 REMARK 465 LYS P 183 REMARK 465 ALA P 184 REMARK 465 ASP P 185 REMARK 465 TYR P 186 REMARK 465 GLU P 187 REMARK 465 LYS P 188 REMARK 465 HIS P 189 REMARK 465 LYS P 190 REMARK 465 VAL P 191 REMARK 465 TYR P 192 REMARK 465 ALA P 193 REMARK 465 CYS P 194 REMARK 465 GLU P 195 REMARK 465 VAL P 196 REMARK 465 THR P 197 REMARK 465 HIS P 198 REMARK 465 GLN P 199 REMARK 465 GLY P 200 REMARK 465 LEU P 201 REMARK 465 SER P 202 REMARK 465 SER P 203 REMARK 465 PRO P 204 REMARK 465 VAL P 205 REMARK 465 THR P 206 REMARK 465 LYS P 207 REMARK 465 SER P 208 REMARK 465 PHE P 209 REMARK 465 ASN P 210 REMARK 465 ARG P 211 REMARK 465 GLY P 212 REMARK 465 GLU P 213 REMARK 465 CYS P 214 REMARK 465 MET E 1 REMARK 465 LYS E 2 REMARK 465 THR E 3 REMARK 465 THR E 4 REMARK 465 CYS E 5 REMARK 465 PHE E 6 REMARK 465 LEU E 7 REMARK 465 ILE E 8 REMARK 465 SER E 9 REMARK 465 LEU E 10 REMARK 465 ILE E 11 REMARK 465 LEU E 12 REMARK 465 ILE E 13 REMARK 465 GLN E 14 REMARK 465 GLY E 15 REMARK 465 THR E 16 REMARK 465 LYS E 17 REMARK 465 ASN E 18 REMARK 465 LEU E 19 REMARK 465 PRO E 20 REMARK 465 ILE E 21 REMARK 465 LEU E 22 REMARK 465 GLU E 23 REMARK 465 ILE E 24 REMARK 465 ALA E 25 REMARK 465 SER E 26 REMARK 465 ASN E 27 REMARK 465 ASN E 28 REMARK 465 GLN E 29 REMARK 465 PRO E 30 REMARK 465 GLN E 31 REMARK 465 ASN E 32 REMARK 465 VAL E 33 REMARK 465 ASP E 34 REMARK 465 SER E 35 REMARK 465 VAL E 36 REMARK 465 CYS E 37 REMARK 465 SER E 38 REMARK 465 GLN E 182 REMARK 465 GLY E 183 REMARK 465 GLN E 184 REMARK 465 GLY E 185 REMARK 465 TYR E 186 REMARK 465 ARG E 187 REMARK 465 HIS E 188 REMARK 465 MET E 189 REMARK 465 ASN E 190 REMARK 465 SER E 220 REMARK 465 THR E 221 REMARK 465 LYS E 222 REMARK 465 ASN E 223 REMARK 465 GLN E 224 REMARK 465 THR E 225 REMARK 465 CYS E 226 REMARK 465 ALA E 227 REMARK 465 PRO E 228 REMARK 465 SER E 229 REMARK 465 LYS E 230 REMARK 465 ILE E 231 REMARK 465 PRO E 232 REMARK 465 PRO E 233 REMARK 465 PRO E 234 REMARK 465 LEU E 235 REMARK 465 PRO E 236 REMARK 465 THR E 237 REMARK 465 ALA E 238 REMARK 465 ARG E 239 REMARK 465 PRO E 240 REMARK 465 GLU E 241 REMARK 465 ILE E 242 REMARK 465 LYS E 243 REMARK 465 LEU E 244 REMARK 465 THR E 245 REMARK 465 SER E 246 REMARK 465 THR E 247 REMARK 465 PRO E 248 REMARK 465 THR E 249 REMARK 465 ASP E 250 REMARK 465 ALA E 251 REMARK 465 THR E 252 REMARK 465 LYS E 253 REMARK 465 LEU E 254 REMARK 465 ASN E 255 REMARK 465 THR E 256 REMARK 465 GLN E 257 REMARK 465 HIS E 258 REMARK 465 LEU E 259 REMARK 465 VAL E 260 REMARK 465 TYR E 261 REMARK 465 PHE E 262 REMARK 465 ARG E 263 REMARK 465 ARG E 264 REMARK 465 LYS E 265 REMARK 465 ARG E 266 REMARK 465 SER F 436 REMARK 465 ILE F 437 REMARK 465 LEU F 438 REMARK 465 ALA F 439 REMARK 465 ARG F 440 REMARK 465 GLU F 441 REMARK 465 GLY F 442 REMARK 465 ASP F 443 REMARK 465 MET F 444 REMARK 465 GLY F 445 REMARK 465 PRO F 446 REMARK 465 ASN F 447 REMARK 465 LEU F 448 REMARK 465 ASP F 449 REMARK 465 GLY F 450 REMARK 465 LEU F 451 REMARK 465 ILE F 452 REMARK 465 ASN F 453 REMARK 465 ALA F 454 REMARK 465 PRO F 455 REMARK 465 ILE F 456 REMARK 465 ASP F 457 REMARK 465 PHE F 458 REMARK 465 ASP F 459 REMARK 465 PRO F 460 REMARK 465 VAL F 461 REMARK 465 PRO F 462 REMARK 465 ASN F 463 REMARK 465 THR F 464 REMARK 465 LYS F 465 REMARK 465 THR F 466 REMARK 465 ILE F 467 REMARK 465 PHE F 468 REMARK 465 ASP F 469 REMARK 465 GLU F 470 REMARK 465 SER F 471 REMARK 465 SER F 472 REMARK 465 SER F 473 REMARK 465 SER F 474 REMARK 465 GLY F 475 REMARK 465 ALA F 476 REMARK 465 SER F 477 REMARK 465 ALA F 478 REMARK 465 GLU F 479 REMARK 465 GLU F 480 REMARK 465 ASP F 481 REMARK 465 GLN F 482 REMARK 465 HIS F 483 REMARK 465 ALA F 484 REMARK 465 SER F 485 REMARK 465 PRO F 486 REMARK 465 ASN F 487 REMARK 465 ILE F 488 REMARK 465 SER F 489 REMARK 465 LEU F 490 REMARK 465 THR F 491 REMARK 465 LEU F 492 REMARK 465 SER F 493 REMARK 465 TYR F 494 REMARK 465 PHE F 495 REMARK 465 PRO F 496 REMARK 465 ASN F 497 REMARK 465 ILE F 498 REMARK 465 ASN F 499 REMARK 465 GLU F 500 REMARK 465 ASN F 501 REMARK 465 THR F 502 REMARK 465 VAL F 521 REMARK 465 GLN F 522 REMARK 465 GLU F 523 REMARK 465 ASP F 524 REMARK 465 ASP F 525 REMARK 465 LEU F 526 REMARK 465 ALA F 527 REMARK 465 ALA F 528 REMARK 465 TRP F 598 REMARK 465 GLY F 599 REMARK 465 GLY F 600 REMARK 465 THR F 601 REMARK 465 CYS F 602 REMARK 465 LYS F 603 REMARK 465 VAL F 604 REMARK 465 LEU F 605 REMARK 465 GLY F 606 REMARK 465 PRO F 607 REMARK 465 ASP F 608 REMARK 465 CYS F 609 REMARK 465 CYS F 610 REMARK 465 ILE F 611 REMARK 465 GLY F 612 REMARK 465 ILE F 613 REMARK 465 GLU F 614 REMARK 465 ASP F 615 REMARK 465 LEU F 616 REMARK 465 SER F 617 REMARK 465 LYS F 618 REMARK 465 ASN F 619 REMARK 465 ILE F 620 REMARK 465 SER F 621 REMARK 465 GLU F 622 REMARK 465 GLN F 623 REMARK 465 ILE F 624 REMARK 465 ASP F 625 REMARK 465 GLN F 626 REMARK 465 ILE F 627 REMARK 465 LYS F 628 REMARK 465 LYS F 629 REMARK 465 ASP F 630 REMARK 465 GLU F 631 REMARK 465 GLN F 632 REMARK 465 LYS F 633 REMARK 465 GLU F 634 REMARK 465 GLY F 635 REMARK 465 THR F 636 REMARK 465 GLY F 637 REMARK 465 SER F 638 REMARK 465 HIS F 639 REMARK 465 HIS F 640 REMARK 465 HIS F 641 REMARK 465 HIS F 642 REMARK 465 HIS F 643 REMARK 465 HIS F 644 REMARK 465 HIS F 645 REMARK 465 HIS F 646 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 GLU H 1 CG CD OE1 OE2 REMARK 470 VAL H 2 CG1 CG2 REMARK 470 SER H 17 OG REMARK 470 SER H 21 OG REMARK 470 SER H 25 OG REMARK 470 SER H 31 OG REMARK 470 GLU H 46 CG CD OE1 OE2 REMARK 470 ASP H 62 CG OD1 OD2 REMARK 470 SER H 63 OG REMARK 470 THR H 69 OG1 CG2 REMARK 470 ASP H 73 CG OD1 OD2 REMARK 470 LYS H 76 CG CD CE NZ REMARK 470 SER H 78 OG REMARK 470 SER H 85 OG REMARK 470 GLU H 89 CG CD OE1 OE2 REMARK 470 GLN H 112 CG CD OE1 NE2 REMARK 470 THR H 114 OG1 CG2 REMARK 470 SER H 119 OG REMARK 470 ASP L 1 CG OD1 OD2 REMARK 470 SER L 7 OG REMARK 470 SER L 9 OG REMARK 470 SER L 14 OG REMARK 470 VAL L 15 CG1 CG2 REMARK 470 ARG L 24 CG CD NE CZ NH1 NH2 REMARK 470 SER L 26 OG REMARK 470 SER L 28 OG REMARK 470 SER L 30 OG REMARK 470 LYS L 42 CG CD CE NZ REMARK 470 SER L 52 OG REMARK 470 SER L 56 OG REMARK 470 SER L 60 OG REMARK 470 SER L 65 OG REMARK 470 GLU L 66 CG CD OE1 OE2 REMARK 470 SER L 67 OG REMARK 470 THR L 69 OG1 CG2 REMARK 470 ASP L 70 CG OD1 OD2 REMARK 470 THR L 72 OG1 CG2 REMARK 470 THR L 74 OG1 CG2 REMARK 470 SER L 76 OG REMARK 470 GLN L 79 CG CD OE1 NE2 REMARK 470 GLU L 81 CG CD OE1 OE2 REMARK 470 ASP L 105 CG OD1 OD2 REMARK 470 THR A 40 OG1 CG2 REMARK 470 LYS A 43 CG CD CE NZ REMARK 470 LEU A 64 CG CD1 CD2 REMARK 470 GLU A 65 CG CD OE1 OE2 REMARK 470 SER A 67 OG REMARK 470 GLU A 82 CG CD OE1 OE2 REMARK 470 THR A 98 OG1 CG2 REMARK 470 ASP A 99 CG OD1 OD2 REMARK 470 SER A 101 OG REMARK 470 LYS A 103 CG CD CE NZ REMARK 470 SER A 104 OG REMARK 470 GLN A 128 CG CD OE1 NE2 REMARK 470 GLN A 133 CG CD OE1 NE2 REMARK 470 THR A 173 OG1 CG2 REMARK 470 LYS A 176 CG CD CE NZ REMARK 470 LEU A 191 CG CD1 CD2 REMARK 470 THR A 192 OG1 CG2 REMARK 470 SER A 201 OG REMARK 470 THR A 204 OG1 CG2 REMARK 470 GLN A 205 CG CD OE1 NE2 REMARK 470 THR A 206 OG1 CG2 REMARK 470 ASN A 207 CG OD1 ND2 REMARK 470 ASP A 208 CG OD1 OD2 REMARK 470 THR A 209 OG1 CG2 REMARK 470 CYS A 211 SG REMARK 470 SER B 531 OG REMARK 470 GLU B 541 CG CD OE1 OE2 REMARK 470 THR B 545 OG1 CG2 REMARK 470 THR B 578 OG1 CG2 REMARK 470 GLU B 579 CG CD OE1 OE2 REMARK 470 GLU B 580 CG CD OE1 OE2 REMARK 470 ARG B 581 CG CD NE CZ NH1 NH2 REMARK 470 SER B 584 OG REMARK 470 ARG B 597 CG CD NE CZ NH1 NH2 REMARK 470 GLU I 1 CG CD OE1 OE2 REMARK 470 VAL I 2 CG1 CG2 REMARK 470 SER I 17 OG REMARK 470 SER I 21 OG REMARK 470 SER I 25 OG REMARK 470 SER I 31 OG REMARK 470 GLU I 46 CG CD OE1 OE2 REMARK 470 ASP I 62 CG OD1 OD2 REMARK 470 SER I 63 OG REMARK 470 THR I 69 OG1 CG2 REMARK 470 ASP I 73 CG OD1 OD2 REMARK 470 LYS I 76 CG CD CE NZ REMARK 470 SER I 78 OG REMARK 470 SER I 85 OG REMARK 470 GLU I 89 CG CD OE1 OE2 REMARK 470 GLN I 112 CG CD OE1 NE2 REMARK 470 THR I 114 OG1 CG2 REMARK 470 SER I 119 OG REMARK 470 ASP N 1 CG OD1 OD2 REMARK 470 SER N 7 OG REMARK 470 SER N 9 OG REMARK 470 SER N 14 OG REMARK 470 VAL N 15 CG1 CG2 REMARK 470 ARG N 24 CG CD NE CZ NH1 NH2 REMARK 470 SER N 26 OG REMARK 470 SER N 28 OG REMARK 470 SER N 30 OG REMARK 470 LYS N 42 CG CD CE NZ REMARK 470 SER N 52 OG REMARK 470 SER N 56 OG REMARK 470 SER N 60 OG REMARK 470 SER N 65 OG REMARK 470 GLU N 66 CG CD OE1 OE2 REMARK 470 SER N 67 OG REMARK 470 THR N 69 OG1 CG2 REMARK 470 ASP N 70 CG OD1 OD2 REMARK 470 THR N 72 OG1 CG2 REMARK 470 THR N 74 OG1 CG2 REMARK 470 SER N 76 OG REMARK 470 GLN N 79 CG CD OE1 NE2 REMARK 470 GLU N 81 CG CD OE1 OE2 REMARK 470 ASP N 105 CG OD1 OD2 REMARK 470 THR C 40 OG1 CG2 REMARK 470 LYS C 43 CG CD CE NZ REMARK 470 LEU C 64 CG CD1 CD2 REMARK 470 GLU C 65 CG CD OE1 OE2 REMARK 470 SER C 67 OG REMARK 470 GLU C 82 CG CD OE1 OE2 REMARK 470 THR C 98 OG1 CG2 REMARK 470 ASP C 99 CG OD1 OD2 REMARK 470 SER C 101 OG REMARK 470 LYS C 103 CG CD CE NZ REMARK 470 SER C 104 OG REMARK 470 GLN C 128 CG CD OE1 NE2 REMARK 470 GLN C 133 CG CD OE1 NE2 REMARK 470 THR C 173 OG1 CG2 REMARK 470 LYS C 176 CG CD CE NZ REMARK 470 LEU C 191 CG CD1 CD2 REMARK 470 THR C 192 OG1 CG2 REMARK 470 SER C 201 OG REMARK 470 THR C 204 OG1 CG2 REMARK 470 GLN C 205 CG CD OE1 NE2 REMARK 470 THR C 206 OG1 CG2 REMARK 470 ASN C 207 CG OD1 ND2 REMARK 470 ASP C 208 CG OD1 OD2 REMARK 470 THR C 209 OG1 CG2 REMARK 470 CYS C 211 SG REMARK 470 SER D 531 OG REMARK 470 GLU D 541 CG CD OE1 OE2 REMARK 470 THR D 545 OG1 CG2 REMARK 470 THR D 578 OG1 CG2 REMARK 470 GLU D 579 CG CD OE1 OE2 REMARK 470 GLU D 580 CG CD OE1 OE2 REMARK 470 ARG D 581 CG CD NE CZ NH1 NH2 REMARK 470 SER D 584 OG REMARK 470 ARG D 597 CG CD NE CZ NH1 NH2 REMARK 470 GLU J 1 CG CD OE1 OE2 REMARK 470 VAL J 2 CG1 CG2 REMARK 470 SER J 17 OG REMARK 470 SER J 21 OG REMARK 470 SER J 25 OG REMARK 470 SER J 31 OG REMARK 470 GLU J 46 CG CD OE1 OE2 REMARK 470 ASP J 62 CG OD1 OD2 REMARK 470 SER J 63 OG REMARK 470 THR J 69 OG1 CG2 REMARK 470 ASP J 73 CG OD1 OD2 REMARK 470 LYS J 76 CG CD CE NZ REMARK 470 SER J 78 OG REMARK 470 SER J 85 OG REMARK 470 GLU J 89 CG CD OE1 OE2 REMARK 470 GLN J 112 CG CD OE1 NE2 REMARK 470 THR J 114 OG1 CG2 REMARK 470 SER J 119 OG REMARK 470 ASP P 1 CG OD1 OD2 REMARK 470 SER P 7 OG REMARK 470 SER P 9 OG REMARK 470 SER P 14 OG REMARK 470 VAL P 15 CG1 CG2 REMARK 470 ARG P 24 CG CD NE CZ NH1 NH2 REMARK 470 SER P 26 OG REMARK 470 SER P 28 OG REMARK 470 SER P 30 OG REMARK 470 LYS P 42 CG CD CE NZ REMARK 470 SER P 52 OG REMARK 470 SER P 56 OG REMARK 470 SER P 60 OG REMARK 470 SER P 65 OG REMARK 470 GLU P 66 CG CD OE1 OE2 REMARK 470 SER P 67 OG REMARK 470 THR P 69 OG1 CG2 REMARK 470 ASP P 70 CG OD1 OD2 REMARK 470 THR P 72 OG1 CG2 REMARK 470 THR P 74 OG1 CG2 REMARK 470 SER P 76 OG REMARK 470 GLN P 79 CG CD OE1 NE2 REMARK 470 GLU P 81 CG CD OE1 OE2 REMARK 470 ASP P 105 CG OD1 OD2 REMARK 470 THR E 40 OG1 CG2 REMARK 470 LYS E 43 CG CD CE NZ REMARK 470 LEU E 64 CG CD1 CD2 REMARK 470 GLU E 65 CG CD OE1 OE2 REMARK 470 SER E 67 OG REMARK 470 GLU E 82 CG CD OE1 OE2 REMARK 470 THR E 98 OG1 CG2 REMARK 470 ASP E 99 CG OD1 OD2 REMARK 470 SER E 101 OG REMARK 470 LYS E 103 CG CD CE NZ REMARK 470 SER E 104 OG REMARK 470 GLN E 128 CG CD OE1 NE2 REMARK 470 GLN E 133 CG CD OE1 NE2 REMARK 470 THR E 173 OG1 CG2 REMARK 470 LYS E 176 CG CD CE NZ REMARK 470 LEU E 191 CG CD1 CD2 REMARK 470 THR E 192 OG1 CG2 REMARK 470 SER E 201 OG REMARK 470 THR E 204 OG1 CG2 REMARK 470 GLN E 205 CG CD OE1 NE2 REMARK 470 THR E 206 OG1 CG2 REMARK 470 ASN E 207 CG OD1 ND2 REMARK 470 ASP E 208 CG OD1 OD2 REMARK 470 THR E 209 OG1 CG2 REMARK 470 CYS E 211 SG REMARK 470 SER F 531 OG REMARK 470 GLU F 541 CG CD OE1 OE2 REMARK 470 THR F 545 OG1 CG2 REMARK 470 THR F 578 OG1 CG2 REMARK 470 GLU F 579 CG CD OE1 OE2 REMARK 470 GLU F 580 CG CD OE1 OE2 REMARK 470 ARG F 581 CG CD NE CZ NH1 NH2 REMARK 470 SER F 584 OG REMARK 470 ARG F 597 CG CD NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 LEU L 54 CB - CG - CD2 ANGL. DEV. = -10.8 DEGREES REMARK 500 LEU N 54 CB - CG - CD2 ANGL. DEV. = -10.8 DEGREES REMARK 500 LEU P 54 CB - CG - CD2 ANGL. DEV. = -10.8 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER L 30 -125.88 65.63 REMARK 500 LEU L 47 -66.19 -101.81 REMARK 500 ALA L 51 -13.79 64.71 REMARK 500 SER L 52 -18.56 -145.82 REMARK 500 SER L 56 128.72 -34.50 REMARK 500 PRO L 80 3.86 -66.03 REMARK 500 TYR L 92 -62.01 -105.66 REMARK 500 THR L 102 114.72 -162.57 REMARK 500 PRO A 78 152.42 -45.02 REMARK 500 TYR A 146 -164.57 -110.33 REMARK 500 ASP A 208 70.43 -110.34 REMARK 500 SER N 30 -125.90 65.65 REMARK 500 LEU N 47 -66.21 -101.79 REMARK 500 ALA N 51 -13.87 64.81 REMARK 500 SER N 52 -18.54 -145.78 REMARK 500 SER N 56 128.73 -34.50 REMARK 500 PRO N 80 3.78 -65.95 REMARK 500 TYR N 92 -61.97 -105.72 REMARK 500 THR N 102 114.73 -162.51 REMARK 500 PRO C 78 152.44 -45.02 REMARK 500 TYR C 146 -164.53 -110.32 REMARK 500 ASP C 208 70.41 -110.38 REMARK 500 SER P 30 -125.88 65.61 REMARK 500 LEU P 47 -66.20 -101.79 REMARK 500 ALA P 51 -13.80 64.75 REMARK 500 SER P 52 -18.49 -145.81 REMARK 500 SER P 56 128.76 -34.53 REMARK 500 PRO P 80 3.82 -66.06 REMARK 500 TYR P 92 -61.99 -105.67 REMARK 500 THR P 102 114.72 -162.56 REMARK 500 PRO E 78 152.43 -45.01 REMARK 500 TYR E 146 -164.55 -110.32 REMARK 500 ASP E 208 70.42 -110.35 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-49486 RELATED DB: EMDB REMARK 900 MARV GP IN COMPLEX WITH MARV16 FAB DBREF 9NJL H 1 223 PDB 9NJL 9NJL 1 223 DBREF 9NJL L 1 214 PDB 9NJL 9NJL 1 214 DBREF 9NJL A 1 256 UNP P35253 VGP_MABVM 1 256 DBREF 9NJL B 436 637 UNP P35253 VGP_MABVM 436 637 DBREF 9NJL I 1 223 PDB 9NJL 9NJL 1 223 DBREF 9NJL N 1 214 PDB 9NJL 9NJL 1 214 DBREF 9NJL C 1 256 UNP P35253 VGP_MABVM 1 256 DBREF 9NJL D 436 637 UNP P35253 VGP_MABVM 436 637 DBREF 9NJL J 1 223 PDB 9NJL 9NJL 1 223 DBREF 9NJL P 1 214 PDB 9NJL 9NJL 1 214 DBREF 9NJL E 1 256 UNP P35253 VGP_MABVM 1 256 DBREF 9NJL F 436 637 UNP P35253 VGP_MABVM 436 637 SEQADV 9NJL GLN A 257 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS A 258 UNP P35253 EXPRESSION TAG SEQADV 9NJL LEU A 259 UNP P35253 EXPRESSION TAG SEQADV 9NJL VAL A 260 UNP P35253 EXPRESSION TAG SEQADV 9NJL TYR A 261 UNP P35253 EXPRESSION TAG SEQADV 9NJL PHE A 262 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG A 263 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG A 264 UNP P35253 EXPRESSION TAG SEQADV 9NJL LYS A 265 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG A 266 UNP P35253 EXPRESSION TAG SEQADV 9NJL ALA B 439 UNP P35253 TRP 439 ENGINEERED MUTATION SEQADV 9NJL GLY B 445 UNP P35253 PHE 445 ENGINEERED MUTATION SEQADV 9NJL ASN B 447 UNP P35253 PHE 447 ENGINEERED MUTATION SEQADV 9NJL ILE B 589 UNP P35253 HIS 589 ENGINEERED MUTATION SEQADV 9NJL SER B 638 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 639 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 640 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 641 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 642 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 643 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 644 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 645 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS B 646 UNP P35253 EXPRESSION TAG SEQADV 9NJL GLN C 257 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS C 258 UNP P35253 EXPRESSION TAG SEQADV 9NJL LEU C 259 UNP P35253 EXPRESSION TAG SEQADV 9NJL VAL C 260 UNP P35253 EXPRESSION TAG SEQADV 9NJL TYR C 261 UNP P35253 EXPRESSION TAG SEQADV 9NJL PHE C 262 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG C 263 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG C 264 UNP P35253 EXPRESSION TAG SEQADV 9NJL LYS C 265 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG C 266 UNP P35253 EXPRESSION TAG SEQADV 9NJL ALA D 439 UNP P35253 TRP 439 ENGINEERED MUTATION SEQADV 9NJL GLY D 445 UNP P35253 PHE 445 ENGINEERED MUTATION SEQADV 9NJL ASN D 447 UNP P35253 PHE 447 ENGINEERED MUTATION SEQADV 9NJL ILE D 589 UNP P35253 HIS 589 ENGINEERED MUTATION SEQADV 9NJL SER D 638 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 639 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 640 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 641 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 642 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 643 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 644 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 645 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS D 646 UNP P35253 EXPRESSION TAG SEQADV 9NJL GLN E 257 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS E 258 UNP P35253 EXPRESSION TAG SEQADV 9NJL LEU E 259 UNP P35253 EXPRESSION TAG SEQADV 9NJL VAL E 260 UNP P35253 EXPRESSION TAG SEQADV 9NJL TYR E 261 UNP P35253 EXPRESSION TAG SEQADV 9NJL PHE E 262 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG E 263 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG E 264 UNP P35253 EXPRESSION TAG SEQADV 9NJL LYS E 265 UNP P35253 EXPRESSION TAG SEQADV 9NJL ARG E 266 UNP P35253 EXPRESSION TAG SEQADV 9NJL ALA F 439 UNP P35253 TRP 439 ENGINEERED MUTATION SEQADV 9NJL GLY F 445 UNP P35253 PHE 445 ENGINEERED MUTATION SEQADV 9NJL ASN F 447 UNP P35253 PHE 447 ENGINEERED MUTATION SEQADV 9NJL ILE F 589 UNP P35253 HIS 589 ENGINEERED MUTATION SEQADV 9NJL SER F 638 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 639 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 640 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 641 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 642 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 643 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 644 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 645 UNP P35253 EXPRESSION TAG SEQADV 9NJL HIS F 646 UNP P35253 EXPRESSION TAG SEQRES 1 H 223 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 H 223 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 H 223 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4 H 223 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 H 223 SER SER GLU SER TYR ILE TYR TYR VAL ASP SER VAL GLN SEQRES 6 H 223 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 H 223 LEU TYR LEU GLN LEU ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 H 223 ALA VAL TYR TYR CYS VAL ARG ARG ASP ASN TRP ASN TYR SEQRES 9 H 223 ASP THR LEU ASP ILE TRP GLY GLN GLY THR MET VAL THR SEQRES 10 H 223 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 H 223 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 H 223 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 H 223 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 H 223 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 H 223 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 H 223 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 H 223 PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SEQRES 18 H 223 SER CYS SEQRES 1 L 214 ASP ILE VAL MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 214 SER VAL GLY ASP ARG VAL ILE ILE THR CYS ARG ALA SER SEQRES 3 L 214 GLN SER ILE SER THR TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 L 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 L 214 SER LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 214 GLU SER GLY THR ASP PHE THR LEU THR ILE SER GLY LEU SEQRES 7 L 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS LEU GLN SER SEQRES 8 L 214 TYR ASP ALA PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 L 214 ASP ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 L 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 L 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 L 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 L 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 L 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 L 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 L 214 PHE ASN ARG GLY GLU CYS SEQRES 1 A 266 MET LYS THR THR CYS PHE LEU ILE SER LEU ILE LEU ILE SEQRES 2 A 266 GLN GLY THR LYS ASN LEU PRO ILE LEU GLU ILE ALA SER SEQRES 3 A 266 ASN ASN GLN PRO GLN ASN VAL ASP SER VAL CYS SER GLY SEQRES 4 A 266 THR LEU GLN LYS THR GLU ASP VAL HIS LEU MET GLY PHE SEQRES 5 A 266 THR LEU SER GLY GLN LYS VAL ALA ASP SER PRO LEU GLU SEQRES 6 A 266 ALA SER LYS ARG TRP ALA PHE ARG THR GLY VAL PRO PRO SEQRES 7 A 266 LYS ASN VAL GLU TYR THR GLU GLY GLU GLU ALA LYS THR SEQRES 8 A 266 CYS TYR ASN ILE SER VAL THR ASP PRO SER GLY LYS SER SEQRES 9 A 266 LEU LEU LEU ASP PRO PRO THR ASN ILE ARG ASP TYR PRO SEQRES 10 A 266 LYS CYS LYS THR ILE HIS HIS ILE GLN GLY GLN ASN PRO SEQRES 11 A 266 HIS ALA GLN GLY ILE ALA LEU HIS LEU TRP GLY ALA PHE SEQRES 12 A 266 PHE LEU TYR ASP ARG ILE ALA SER THR THR MET TYR ARG SEQRES 13 A 266 GLY LYS VAL PHE THR GLU GLY ASN ILE ALA ALA MET ILE SEQRES 14 A 266 VAL ASN LYS THR VAL HIS LYS MET ILE PHE SER ARG GLN SEQRES 15 A 266 GLY GLN GLY TYR ARG HIS MET ASN LEU THR SER THR ASN SEQRES 16 A 266 LYS TYR TRP THR SER SER ASN GLY THR GLN THR ASN ASP SEQRES 17 A 266 THR GLY CYS PHE GLY ALA LEU GLN GLU TYR ASN SER THR SEQRES 18 A 266 LYS ASN GLN THR CYS ALA PRO SER LYS ILE PRO PRO PRO SEQRES 19 A 266 LEU PRO THR ALA ARG PRO GLU ILE LYS LEU THR SER THR SEQRES 20 A 266 PRO THR ASP ALA THR LYS LEU ASN THR GLN HIS LEU VAL SEQRES 21 A 266 TYR PHE ARG ARG LYS ARG SEQRES 1 B 211 SER ILE LEU ALA ARG GLU GLY ASP MET GLY PRO ASN LEU SEQRES 2 B 211 ASP GLY LEU ILE ASN ALA PRO ILE ASP PHE ASP PRO VAL SEQRES 3 B 211 PRO ASN THR LYS THR ILE PHE ASP GLU SER SER SER SER SEQRES 4 B 211 GLY ALA SER ALA GLU GLU ASP GLN HIS ALA SER PRO ASN SEQRES 5 B 211 ILE SER LEU THR LEU SER TYR PHE PRO ASN ILE ASN GLU SEQRES 6 B 211 ASN THR ALA TYR SER GLY GLU ASN GLU ASN ASP CYS ASP SEQRES 7 B 211 ALA GLU LEU ARG ILE TRP SER VAL GLN GLU ASP ASP LEU SEQRES 8 B 211 ALA ALA GLY LEU SER TRP ILE PRO PHE PHE GLY PRO GLY SEQRES 9 B 211 ILE GLU GLY LEU TYR THR ALA VAL LEU ILE LYS ASN GLN SEQRES 10 B 211 ASN ASN LEU VAL CYS ARG LEU ARG ARG LEU ALA ASN GLN SEQRES 11 B 211 THR ALA LYS SER LEU GLU LEU LEU LEU ARG VAL THR THR SEQRES 12 B 211 GLU GLU ARG THR PHE SER LEU ILE ASN ARG ILE ALA ILE SEQRES 13 B 211 ASP PHE LEU LEU THR ARG TRP GLY GLY THR CYS LYS VAL SEQRES 14 B 211 LEU GLY PRO ASP CYS CYS ILE GLY ILE GLU ASP LEU SER SEQRES 15 B 211 LYS ASN ILE SER GLU GLN ILE ASP GLN ILE LYS LYS ASP SEQRES 16 B 211 GLU GLN LYS GLU GLY THR GLY SER HIS HIS HIS HIS HIS SEQRES 17 B 211 HIS HIS HIS SEQRES 1 I 223 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 I 223 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 I 223 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4 I 223 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 I 223 SER SER GLU SER TYR ILE TYR TYR VAL ASP SER VAL GLN SEQRES 6 I 223 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 I 223 LEU TYR LEU GLN LEU ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 I 223 ALA VAL TYR TYR CYS VAL ARG ARG ASP ASN TRP ASN TYR SEQRES 9 I 223 ASP THR LEU ASP ILE TRP GLY GLN GLY THR MET VAL THR SEQRES 10 I 223 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 I 223 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 I 223 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 I 223 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 I 223 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 I 223 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 I 223 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 I 223 PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SEQRES 18 I 223 SER CYS SEQRES 1 N 214 ASP ILE VAL MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 N 214 SER VAL GLY ASP ARG VAL ILE ILE THR CYS ARG ALA SER SEQRES 3 N 214 GLN SER ILE SER THR TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 N 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 N 214 SER LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 N 214 GLU SER GLY THR ASP PHE THR LEU THR ILE SER GLY LEU SEQRES 7 N 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS LEU GLN SER SEQRES 8 N 214 TYR ASP ALA PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 N 214 ASP ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 N 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 N 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 N 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 N 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 N 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 N 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 N 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 N 214 PHE ASN ARG GLY GLU CYS SEQRES 1 C 266 MET LYS THR THR CYS PHE LEU ILE SER LEU ILE LEU ILE SEQRES 2 C 266 GLN GLY THR LYS ASN LEU PRO ILE LEU GLU ILE ALA SER SEQRES 3 C 266 ASN ASN GLN PRO GLN ASN VAL ASP SER VAL CYS SER GLY SEQRES 4 C 266 THR LEU GLN LYS THR GLU ASP VAL HIS LEU MET GLY PHE SEQRES 5 C 266 THR LEU SER GLY GLN LYS VAL ALA ASP SER PRO LEU GLU SEQRES 6 C 266 ALA SER LYS ARG TRP ALA PHE ARG THR GLY VAL PRO PRO SEQRES 7 C 266 LYS ASN VAL GLU TYR THR GLU GLY GLU GLU ALA LYS THR SEQRES 8 C 266 CYS TYR ASN ILE SER VAL THR ASP PRO SER GLY LYS SER SEQRES 9 C 266 LEU LEU LEU ASP PRO PRO THR ASN ILE ARG ASP TYR PRO SEQRES 10 C 266 LYS CYS LYS THR ILE HIS HIS ILE GLN GLY GLN ASN PRO SEQRES 11 C 266 HIS ALA GLN GLY ILE ALA LEU HIS LEU TRP GLY ALA PHE SEQRES 12 C 266 PHE LEU TYR ASP ARG ILE ALA SER THR THR MET TYR ARG SEQRES 13 C 266 GLY LYS VAL PHE THR GLU GLY ASN ILE ALA ALA MET ILE SEQRES 14 C 266 VAL ASN LYS THR VAL HIS LYS MET ILE PHE SER ARG GLN SEQRES 15 C 266 GLY GLN GLY TYR ARG HIS MET ASN LEU THR SER THR ASN SEQRES 16 C 266 LYS TYR TRP THR SER SER ASN GLY THR GLN THR ASN ASP SEQRES 17 C 266 THR GLY CYS PHE GLY ALA LEU GLN GLU TYR ASN SER THR SEQRES 18 C 266 LYS ASN GLN THR CYS ALA PRO SER LYS ILE PRO PRO PRO SEQRES 19 C 266 LEU PRO THR ALA ARG PRO GLU ILE LYS LEU THR SER THR SEQRES 20 C 266 PRO THR ASP ALA THR LYS LEU ASN THR GLN HIS LEU VAL SEQRES 21 C 266 TYR PHE ARG ARG LYS ARG SEQRES 1 D 211 SER ILE LEU ALA ARG GLU GLY ASP MET GLY PRO ASN LEU SEQRES 2 D 211 ASP GLY LEU ILE ASN ALA PRO ILE ASP PHE ASP PRO VAL SEQRES 3 D 211 PRO ASN THR LYS THR ILE PHE ASP GLU SER SER SER SER SEQRES 4 D 211 GLY ALA SER ALA GLU GLU ASP GLN HIS ALA SER PRO ASN SEQRES 5 D 211 ILE SER LEU THR LEU SER TYR PHE PRO ASN ILE ASN GLU SEQRES 6 D 211 ASN THR ALA TYR SER GLY GLU ASN GLU ASN ASP CYS ASP SEQRES 7 D 211 ALA GLU LEU ARG ILE TRP SER VAL GLN GLU ASP ASP LEU SEQRES 8 D 211 ALA ALA GLY LEU SER TRP ILE PRO PHE PHE GLY PRO GLY SEQRES 9 D 211 ILE GLU GLY LEU TYR THR ALA VAL LEU ILE LYS ASN GLN SEQRES 10 D 211 ASN ASN LEU VAL CYS ARG LEU ARG ARG LEU ALA ASN GLN SEQRES 11 D 211 THR ALA LYS SER LEU GLU LEU LEU LEU ARG VAL THR THR SEQRES 12 D 211 GLU GLU ARG THR PHE SER LEU ILE ASN ARG ILE ALA ILE SEQRES 13 D 211 ASP PHE LEU LEU THR ARG TRP GLY GLY THR CYS LYS VAL SEQRES 14 D 211 LEU GLY PRO ASP CYS CYS ILE GLY ILE GLU ASP LEU SER SEQRES 15 D 211 LYS ASN ILE SER GLU GLN ILE ASP GLN ILE LYS LYS ASP SEQRES 16 D 211 GLU GLN LYS GLU GLY THR GLY SER HIS HIS HIS HIS HIS SEQRES 17 D 211 HIS HIS HIS SEQRES 1 J 223 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS SEQRES 2 J 223 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 J 223 PHE THR PHE SER SER TYR THR MET ASN TRP VAL ARG GLN SEQRES 4 J 223 ALA PRO GLY LYS GLY LEU GLU TRP VAL SER SER ILE SER SEQRES 5 J 223 SER SER GLU SER TYR ILE TYR TYR VAL ASP SER VAL GLN SEQRES 6 J 223 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER SEQRES 7 J 223 LEU TYR LEU GLN LEU ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 J 223 ALA VAL TYR TYR CYS VAL ARG ARG ASP ASN TRP ASN TYR SEQRES 9 J 223 ASP THR LEU ASP ILE TRP GLY GLN GLY THR MET VAL THR SEQRES 10 J 223 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 J 223 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 J 223 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 J 223 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 J 223 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 J 223 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 J 223 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 J 223 PRO SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SEQRES 18 J 223 SER CYS SEQRES 1 P 214 ASP ILE VAL MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 P 214 SER VAL GLY ASP ARG VAL ILE ILE THR CYS ARG ALA SER SEQRES 3 P 214 GLN SER ILE SER THR TYR LEU ASN TRP TYR GLN GLN LYS SEQRES 4 P 214 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 P 214 SER LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 P 214 GLU SER GLY THR ASP PHE THR LEU THR ILE SER GLY LEU SEQRES 7 P 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS LEU GLN SER SEQRES 8 P 214 TYR ASP ALA PRO LEU THR PHE GLY GLY GLY THR LYS VAL SEQRES 9 P 214 ASP ILE LYS ARG THR VAL ALA ALA PRO SER VAL PHE ILE SEQRES 10 P 214 PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY THR ALA SEQRES 11 P 214 SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO ARG GLU SEQRES 12 P 214 ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU GLN SER SEQRES 13 P 214 GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP SER LYS SEQRES 14 P 214 ASP SER THR TYR SER LEU SER SER THR LEU THR LEU SER SEQRES 15 P 214 LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA CYS GLU SEQRES 16 P 214 VAL THR HIS GLN GLY LEU SER SER PRO VAL THR LYS SER SEQRES 17 P 214 PHE ASN ARG GLY GLU CYS SEQRES 1 E 266 MET LYS THR THR CYS PHE LEU ILE SER LEU ILE LEU ILE SEQRES 2 E 266 GLN GLY THR LYS ASN LEU PRO ILE LEU GLU ILE ALA SER SEQRES 3 E 266 ASN ASN GLN PRO GLN ASN VAL ASP SER VAL CYS SER GLY SEQRES 4 E 266 THR LEU GLN LYS THR GLU ASP VAL HIS LEU MET GLY PHE SEQRES 5 E 266 THR LEU SER GLY GLN LYS VAL ALA ASP SER PRO LEU GLU SEQRES 6 E 266 ALA SER LYS ARG TRP ALA PHE ARG THR GLY VAL PRO PRO SEQRES 7 E 266 LYS ASN VAL GLU TYR THR GLU GLY GLU GLU ALA LYS THR SEQRES 8 E 266 CYS TYR ASN ILE SER VAL THR ASP PRO SER GLY LYS SER SEQRES 9 E 266 LEU LEU LEU ASP PRO PRO THR ASN ILE ARG ASP TYR PRO SEQRES 10 E 266 LYS CYS LYS THR ILE HIS HIS ILE GLN GLY GLN ASN PRO SEQRES 11 E 266 HIS ALA GLN GLY ILE ALA LEU HIS LEU TRP GLY ALA PHE SEQRES 12 E 266 PHE LEU TYR ASP ARG ILE ALA SER THR THR MET TYR ARG SEQRES 13 E 266 GLY LYS VAL PHE THR GLU GLY ASN ILE ALA ALA MET ILE SEQRES 14 E 266 VAL ASN LYS THR VAL HIS LYS MET ILE PHE SER ARG GLN SEQRES 15 E 266 GLY GLN GLY TYR ARG HIS MET ASN LEU THR SER THR ASN SEQRES 16 E 266 LYS TYR TRP THR SER SER ASN GLY THR GLN THR ASN ASP SEQRES 17 E 266 THR GLY CYS PHE GLY ALA LEU GLN GLU TYR ASN SER THR SEQRES 18 E 266 LYS ASN GLN THR CYS ALA PRO SER LYS ILE PRO PRO PRO SEQRES 19 E 266 LEU PRO THR ALA ARG PRO GLU ILE LYS LEU THR SER THR SEQRES 20 E 266 PRO THR ASP ALA THR LYS LEU ASN THR GLN HIS LEU VAL SEQRES 21 E 266 TYR PHE ARG ARG LYS ARG SEQRES 1 F 211 SER ILE LEU ALA ARG GLU GLY ASP MET GLY PRO ASN LEU SEQRES 2 F 211 ASP GLY LEU ILE ASN ALA PRO ILE ASP PHE ASP PRO VAL SEQRES 3 F 211 PRO ASN THR LYS THR ILE PHE ASP GLU SER SER SER SER SEQRES 4 F 211 GLY ALA SER ALA GLU GLU ASP GLN HIS ALA SER PRO ASN SEQRES 5 F 211 ILE SER LEU THR LEU SER TYR PHE PRO ASN ILE ASN GLU SEQRES 6 F 211 ASN THR ALA TYR SER GLY GLU ASN GLU ASN ASP CYS ASP SEQRES 7 F 211 ALA GLU LEU ARG ILE TRP SER VAL GLN GLU ASP ASP LEU SEQRES 8 F 211 ALA ALA GLY LEU SER TRP ILE PRO PHE PHE GLY PRO GLY SEQRES 9 F 211 ILE GLU GLY LEU TYR THR ALA VAL LEU ILE LYS ASN GLN SEQRES 10 F 211 ASN ASN LEU VAL CYS ARG LEU ARG ARG LEU ALA ASN GLN SEQRES 11 F 211 THR ALA LYS SER LEU GLU LEU LEU LEU ARG VAL THR THR SEQRES 12 F 211 GLU GLU ARG THR PHE SER LEU ILE ASN ARG ILE ALA ILE SEQRES 13 F 211 ASP PHE LEU LEU THR ARG TRP GLY GLY THR CYS LYS VAL SEQRES 14 F 211 LEU GLY PRO ASP CYS CYS ILE GLY ILE GLU ASP LEU SER SEQRES 15 F 211 LYS ASN ILE SER GLU GLN ILE ASP GLN ILE LYS LYS ASP SEQRES 16 F 211 GLU GLN LYS GLU GLY THR GLY SER HIS HIS HIS HIS HIS SEQRES 17 F 211 HIS HIS HIS HET NAG G 1 14 HET NAG G 2 14 HET BMA G 3 11 HET NAG K 1 14 HET NAG K 2 14 HET BMA K 3 11 HET MAN K 4 11 HET MAN K 5 11 HET MAN K 6 11 HET NAG M 1 14 HET NAG M 2 14 HET BMA M 3 11 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET MAN O 4 11 HET MAN O 5 11 HET MAN O 6 11 HET NAG Q 1 14 HET NAG Q 2 14 HET BMA Q 3 11 HET NAG R 1 14 HET NAG R 2 14 HET BMA R 3 11 HET MAN R 4 11 HET MAN R 5 11 HET MAN R 6 11 HET NAG A 301 14 HET NAG A 302 14 HET NAG A 303 14 HET NAG C 301 14 HET NAG C 302 14 HET NAG C 303 14 HET NAG E 301 14 HET NAG E 302 14 HET NAG E 303 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 13 NAG 21(C8 H15 N O6) FORMUL 13 BMA 6(C6 H12 O6) FORMUL 14 MAN 9(C6 H12 O6) FORMUL 28 HOH *54(H2 O) HELIX 1 AA1 THR H 28 TYR H 32 5 5 HELIX 2 AA2 ARG H 87 THR H 91 5 5 HELIX 3 AA3 SER A 55 LYS A 58 5 4 HELIX 4 AA4 SER A 62 LYS A 68 1 7 HELIX 5 AA5 ASN A 171 PHE A 179 1 9 HELIX 6 AA6 GLY B 529 ILE B 533 5 5 HELIX 7 AA7 ASN B 554 THR B 577 1 24 HELIX 8 AA8 LEU B 585 ARG B 597 1 13 HELIX 9 AA9 THR I 28 TYR I 32 5 5 HELIX 10 AB1 ARG I 87 THR I 91 5 5 HELIX 11 AB2 LYS C 43 GLU C 45 5 3 HELIX 12 AB3 SER C 55 LYS C 58 5 4 HELIX 13 AB4 SER C 62 LYS C 68 1 7 HELIX 14 AB5 ASN C 171 PHE C 179 1 9 HELIX 15 AB6 GLY D 529 ILE D 533 5 5 HELIX 16 AB7 ASN D 554 THR D 577 1 24 HELIX 17 AB8 LEU D 585 ARG D 597 1 13 HELIX 18 AB9 THR J 28 TYR J 32 5 5 HELIX 19 AC1 ARG J 87 THR J 91 5 5 HELIX 20 AC2 SER E 55 LYS E 58 5 4 HELIX 21 AC3 SER E 62 LYS E 68 1 7 HELIX 22 AC4 ASN E 171 PHE E 179 1 9 HELIX 23 AC5 GLY F 529 ILE F 533 5 5 HELIX 24 AC6 ASN F 554 THR F 577 1 24 HELIX 25 AC7 LEU F 585 ARG F 597 1 13 SHEET 1 AA1 4 GLN H 3 SER H 7 0 SHEET 2 AA1 4 LEU H 18 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AA1 4 SER H 78 LEU H 83 -1 O LEU H 83 N LEU H 18 SHEET 4 AA1 4 PHE H 68 ASP H 73 -1 N SER H 71 O TYR H 80 SHEET 1 AA2 6 LEU H 11 VAL H 12 0 SHEET 2 AA2 6 THR H 114 VAL H 118 1 O THR H 117 N VAL H 12 SHEET 3 AA2 6 ALA H 92 ARG H 99 -1 N TYR H 94 O THR H 114 SHEET 4 AA2 6 THR H 33 GLN H 39 -1 N THR H 33 O ARG H 99 SHEET 5 AA2 6 LEU H 45 ILE H 51 -1 O VAL H 48 N TRP H 36 SHEET 6 AA2 6 ILE H 58 TYR H 60 -1 O TYR H 59 N SER H 50 SHEET 1 AA3 4 LEU H 11 VAL H 12 0 SHEET 2 AA3 4 THR H 114 VAL H 118 1 O THR H 117 N VAL H 12 SHEET 3 AA3 4 ALA H 92 ARG H 99 -1 N TYR H 94 O THR H 114 SHEET 4 AA3 4 LEU H 107 ILE H 109 -1 O ILE H 109 N ARG H 98 SHEET 1 AA4 4 MET L 4 SER L 7 0 SHEET 2 AA4 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AA4 4 ASP L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AA4 4 PHE L 62 SER L 67 -1 N SER L 67 O ASP L 70 SHEET 1 AA5 2 SER L 10 ALA L 13 0 SHEET 2 AA5 2 LYS L 103 ILE L 106 1 O LYS L 103 N LEU L 11 SHEET 1 AA6 4 LYS L 45 LEU L 46 0 SHEET 2 AA6 4 LEU L 33 GLN L 38 -1 N GLN L 37 O LYS L 45 SHEET 3 AA6 4 THR L 85 GLN L 90 -1 O THR L 85 N GLN L 38 SHEET 4 AA6 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AA7 2 ILE L 48 TYR L 49 0 SHEET 2 AA7 2 SER L 53 LEU L 54 -1 O SER L 53 N TYR L 49 SHEET 1 AA8 8 ASN A 80 GLU A 82 0 SHEET 2 AA8 8 ILE A 149 SER A 151 -1 O ALA A 150 N VAL A 81 SHEET 3 AA8 8 PHE A 143 LEU A 145 -1 N PHE A 144 O SER A 151 SHEET 4 AA8 8 VAL A 159 ILE A 169 -1 O THR A 161 N LEU A 145 SHEET 5 AA8 8 ALA A 89 THR A 98 -1 N TYR A 93 O PHE A 160 SHEET 6 AA8 8 CYS A 119 GLN A 128 1 O ILE A 125 N SER A 96 SHEET 7 AA8 8 THR A 194 SER A 200 1 O LYS A 196 N HIS A 124 SHEET 8 AA8 8 LEU A 215 GLU A 217 -1 O GLN A 216 N THR A 199 SHEET 1 AA9 8 ASN A 80 GLU A 82 0 SHEET 2 AA9 8 ILE A 149 SER A 151 -1 O ALA A 150 N VAL A 81 SHEET 3 AA9 8 PHE A 143 LEU A 145 -1 N PHE A 144 O SER A 151 SHEET 4 AA9 8 VAL A 159 ILE A 169 -1 O THR A 161 N LEU A 145 SHEET 5 AA9 8 VAL A 47 THR A 53 -1 N PHE A 52 O ASN A 164 SHEET 6 AA9 8 GLU A 85 GLU A 87 1 O GLU A 87 N GLY A 51 SHEET 7 AA9 8 LEU B 516 SER B 520 -1 O TRP B 519 N GLY A 86 SHEET 8 AA9 8 THR B 545 ILE B 549 -1 O THR B 545 N SER B 520 SHEET 1 AB1 2 TRP A 70 ARG A 73 0 SHEET 2 AB1 2 ILE A 135 HIS A 138 -1 O LEU A 137 N ALA A 71 SHEET 1 AB2 4 GLN I 3 SER I 7 0 SHEET 2 AB2 4 LEU I 18 SER I 25 -1 O SER I 25 N GLN I 3 SHEET 3 AB2 4 SER I 78 LEU I 83 -1 O LEU I 83 N LEU I 18 SHEET 4 AB2 4 PHE I 68 ASP I 73 -1 N SER I 71 O TYR I 80 SHEET 1 AB3 6 LEU I 11 VAL I 12 0 SHEET 2 AB3 6 THR I 114 VAL I 118 1 O THR I 117 N VAL I 12 SHEET 3 AB3 6 ALA I 92 ARG I 99 -1 N TYR I 94 O THR I 114 SHEET 4 AB3 6 THR I 33 GLN I 39 -1 N THR I 33 O ARG I 99 SHEET 5 AB3 6 LEU I 45 ILE I 51 -1 O VAL I 48 N TRP I 36 SHEET 6 AB3 6 ILE I 58 TYR I 60 -1 O TYR I 59 N SER I 50 SHEET 1 AB4 4 LEU I 11 VAL I 12 0 SHEET 2 AB4 4 THR I 114 VAL I 118 1 O THR I 117 N VAL I 12 SHEET 3 AB4 4 ALA I 92 ARG I 99 -1 N TYR I 94 O THR I 114 SHEET 4 AB4 4 LEU I 107 ILE I 109 -1 O ILE I 109 N ARG I 98 SHEET 1 AB5 4 MET N 4 SER N 7 0 SHEET 2 AB5 4 VAL N 19 ALA N 25 -1 O ARG N 24 N THR N 5 SHEET 3 AB5 4 ASP N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 4 AB5 4 PHE N 62 SER N 67 -1 N SER N 67 O ASP N 70 SHEET 1 AB6 2 SER N 10 ALA N 13 0 SHEET 2 AB6 2 LYS N 103 ILE N 106 1 O LYS N 103 N LEU N 11 SHEET 1 AB7 4 LYS N 45 LEU N 46 0 SHEET 2 AB7 4 LEU N 33 GLN N 38 -1 N GLN N 37 O LYS N 45 SHEET 3 AB7 4 THR N 85 GLN N 90 -1 O THR N 85 N GLN N 38 SHEET 4 AB7 4 THR N 97 PHE N 98 -1 O THR N 97 N GLN N 90 SHEET 1 AB8 2 ILE N 48 TYR N 49 0 SHEET 2 AB8 2 SER N 53 LEU N 54 -1 O SER N 53 N TYR N 49 SHEET 1 AB9 8 ASN C 80 GLU C 82 0 SHEET 2 AB9 8 ILE C 149 SER C 151 -1 O ALA C 150 N VAL C 81 SHEET 3 AB9 8 PHE C 143 LEU C 145 -1 N PHE C 144 O SER C 151 SHEET 4 AB9 8 VAL C 159 ILE C 169 -1 O THR C 161 N LEU C 145 SHEET 5 AB9 8 ALA C 89 THR C 98 -1 N TYR C 93 O PHE C 160 SHEET 6 AB9 8 CYS C 119 GLN C 128 1 O ILE C 125 N SER C 96 SHEET 7 AB9 8 THR C 194 SER C 200 1 O LYS C 196 N HIS C 124 SHEET 8 AB9 8 LEU C 215 GLU C 217 -1 O GLN C 216 N THR C 199 SHEET 1 AC1 8 ASN C 80 GLU C 82 0 SHEET 2 AC1 8 ILE C 149 SER C 151 -1 O ALA C 150 N VAL C 81 SHEET 3 AC1 8 PHE C 143 LEU C 145 -1 N PHE C 144 O SER C 151 SHEET 4 AC1 8 VAL C 159 ILE C 169 -1 O THR C 161 N LEU C 145 SHEET 5 AC1 8 VAL C 47 THR C 53 -1 N PHE C 52 O ASN C 164 SHEET 6 AC1 8 GLU C 85 GLU C 87 1 O GLU C 87 N GLY C 51 SHEET 7 AC1 8 LEU D 516 SER D 520 -1 O TRP D 519 N GLY C 86 SHEET 8 AC1 8 THR D 545 ILE D 549 -1 O THR D 545 N SER D 520 SHEET 1 AC2 2 TRP C 70 ARG C 73 0 SHEET 2 AC2 2 ILE C 135 HIS C 138 -1 O LEU C 137 N ALA C 71 SHEET 1 AC3 4 GLN J 3 SER J 7 0 SHEET 2 AC3 4 LEU J 18 SER J 25 -1 O SER J 25 N GLN J 3 SHEET 3 AC3 4 SER J 78 LEU J 83 -1 O LEU J 83 N LEU J 18 SHEET 4 AC3 4 PHE J 68 ASP J 73 -1 N SER J 71 O TYR J 80 SHEET 1 AC4 6 LEU J 11 VAL J 12 0 SHEET 2 AC4 6 THR J 114 VAL J 118 1 O THR J 117 N VAL J 12 SHEET 3 AC4 6 ALA J 92 ARG J 99 -1 N TYR J 94 O THR J 114 SHEET 4 AC4 6 THR J 33 GLN J 39 -1 N THR J 33 O ARG J 99 SHEET 5 AC4 6 LEU J 45 ILE J 51 -1 O VAL J 48 N TRP J 36 SHEET 6 AC4 6 ILE J 58 TYR J 60 -1 O TYR J 59 N SER J 50 SHEET 1 AC5 4 LEU J 11 VAL J 12 0 SHEET 2 AC5 4 THR J 114 VAL J 118 1 O THR J 117 N VAL J 12 SHEET 3 AC5 4 ALA J 92 ARG J 99 -1 N TYR J 94 O THR J 114 SHEET 4 AC5 4 LEU J 107 ILE J 109 -1 O ILE J 109 N ARG J 98 SHEET 1 AC6 4 MET P 4 SER P 7 0 SHEET 2 AC6 4 VAL P 19 ALA P 25 -1 O ARG P 24 N THR P 5 SHEET 3 AC6 4 ASP P 70 ILE P 75 -1 O LEU P 73 N ILE P 21 SHEET 4 AC6 4 PHE P 62 SER P 67 -1 N SER P 67 O ASP P 70 SHEET 1 AC7 2 SER P 10 ALA P 13 0 SHEET 2 AC7 2 LYS P 103 ILE P 106 1 O LYS P 103 N LEU P 11 SHEET 1 AC8 4 LYS P 45 LEU P 46 0 SHEET 2 AC8 4 LEU P 33 GLN P 38 -1 N GLN P 37 O LYS P 45 SHEET 3 AC8 4 THR P 85 GLN P 90 -1 O THR P 85 N GLN P 38 SHEET 4 AC8 4 THR P 97 PHE P 98 -1 O THR P 97 N GLN P 90 SHEET 1 AC9 2 ILE P 48 TYR P 49 0 SHEET 2 AC9 2 SER P 53 LEU P 54 -1 O SER P 53 N TYR P 49 SHEET 1 AD1 8 ASN E 80 GLU E 82 0 SHEET 2 AD1 8 ILE E 149 SER E 151 -1 O ALA E 150 N VAL E 81 SHEET 3 AD1 8 PHE E 143 LEU E 145 -1 N PHE E 144 O SER E 151 SHEET 4 AD1 8 VAL E 159 ILE E 169 -1 O THR E 161 N LEU E 145 SHEET 5 AD1 8 ALA E 89 THR E 98 -1 N TYR E 93 O PHE E 160 SHEET 6 AD1 8 CYS E 119 GLN E 128 1 O ILE E 125 N SER E 96 SHEET 7 AD1 8 THR E 194 SER E 200 1 O LYS E 196 N HIS E 124 SHEET 8 AD1 8 LEU E 215 GLU E 217 -1 O GLN E 216 N THR E 199 SHEET 1 AD2 8 ASN E 80 GLU E 82 0 SHEET 2 AD2 8 ILE E 149 SER E 151 -1 O ALA E 150 N VAL E 81 SHEET 3 AD2 8 PHE E 143 LEU E 145 -1 N PHE E 144 O SER E 151 SHEET 4 AD2 8 VAL E 159 ILE E 169 -1 O THR E 161 N LEU E 145 SHEET 5 AD2 8 VAL E 47 THR E 53 -1 N PHE E 52 O ASN E 164 SHEET 6 AD2 8 GLU E 85 GLU E 87 1 O GLU E 87 N GLY E 51 SHEET 7 AD2 8 LEU F 516 SER F 520 -1 O TRP F 519 N GLY E 86 SHEET 8 AD2 8 THR F 545 ILE F 549 -1 O THR F 545 N SER F 520 SHEET 1 AD3 2 TRP E 70 ARG E 73 0 SHEET 2 AD3 2 ILE E 135 HIS E 138 -1 O LEU E 137 N ALA E 71 SSBOND 1 CYS H 22 CYS H 96 1555 1555 2.04 SSBOND 2 CYS L 23 CYS L 88 1555 1555 2.05 SSBOND 3 CYS A 92 CYS A 119 1555 1555 2.03 SSBOND 4 CYS B 512 CYS B 557 1555 1555 2.03 SSBOND 5 CYS I 22 CYS I 96 1555 1555 2.04 SSBOND 6 CYS N 23 CYS N 88 1555 1555 2.05 SSBOND 7 CYS C 92 CYS C 119 1555 1555 2.03 SSBOND 8 CYS D 512 CYS D 557 1555 1555 2.03 SSBOND 9 CYS J 22 CYS J 96 1555 1555 2.04 SSBOND 10 CYS P 23 CYS P 88 1555 1555 2.05 SSBOND 11 CYS E 92 CYS E 119 1555 1555 2.03 SSBOND 12 CYS F 512 CYS F 557 1555 1555 2.03 LINK ND2 ASN A 94 C1 NAG G 1 1555 1555 1.43 LINK ND2 ASN A 171 C1 NAG A 301 1555 1555 1.44 LINK ND2 ASN A 202 C1 NAG A 303 1555 1555 1.45 LINK ND2 ASN A 219 C1 NAG A 302 1555 1555 1.44 LINK ND2 ASN B 564 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN C 94 C1 NAG M 1 1555 1555 1.43 LINK ND2 ASN C 171 C1 NAG C 301 1555 1555 1.44 LINK ND2 ASN C 202 C1 NAG C 303 1555 1555 1.45 LINK ND2 ASN C 219 C1 NAG C 302 1555 1555 1.44 LINK ND2 ASN D 564 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN E 94 C1 NAG Q 1 1555 1555 1.43 LINK ND2 ASN E 171 C1 NAG E 301 1555 1555 1.44 LINK ND2 ASN E 202 C1 NAG E 303 1555 1555 1.45 LINK ND2 ASN E 219 C1 NAG E 302 1555 1555 1.44 LINK ND2 ASN F 564 C1 NAG R 1 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG G 2 C1 BMA G 3 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.44 LINK O3 BMA K 3 C1 MAN K 4 1555 1555 1.45 LINK O6 BMA K 3 C1 MAN K 6 1555 1555 1.45 LINK O2 MAN K 4 C1 MAN K 5 1555 1555 1.45 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.44 LINK O3 BMA O 3 C1 MAN O 4 1555 1555 1.45 LINK O6 BMA O 3 C1 MAN O 6 1555 1555 1.45 LINK O2 MAN O 4 C1 MAN O 5 1555 1555 1.45 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG Q 2 C1 BMA Q 3 1555 1555 1.45 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG R 2 C1 BMA R 3 1555 1555 1.44 LINK O3 BMA R 3 C1 MAN R 4 1555 1555 1.44 LINK O6 BMA R 3 C1 MAN R 6 1555 1555 1.45 LINK O2 MAN R 4 C1 MAN R 5 1555 1555 1.45 CISPEP 1 SER L 7 PRO L 8 0 -5.82 CISPEP 2 ALA L 94 PRO L 95 0 14.35 CISPEP 3 SER N 7 PRO N 8 0 -5.88 CISPEP 4 ALA N 94 PRO N 95 0 14.37 CISPEP 5 SER P 7 PRO P 8 0 -5.80 CISPEP 6 ALA P 94 PRO P 95 0 14.32 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000