HEADER VIRAL PROTEIN/IMMUNE SYSTEM 08-APR-25 9O4P TITLE CRYO-EM STRUCTURE OF AF9C-GL FAB IN COMPLEX WITH INFLUENZA VIRUS TITLE 2 NEURAMINIDASE FROM A/CALIFORNIA/07/2009 (H1N1) COMPND MOL_ID: 1; COMPND 2 MOLECULE: NEURAMINIDASE; COMPND 3 CHAIN: A, B, C, D; COMPND 4 EC: 3.2.1.18; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: AF9C-GL HEAVY CHAIN; COMPND 8 CHAIN: E, F, G, H; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: AF9C-GL LIGHT CHAIN; COMPND 12 CHAIN: I, J, K, L; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)); SOURCE 3 ORGANISM_TAXID: 641809; SOURCE 4 GENE: NA; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS NEURAMINIDASE, HYDROLASE, ANTIBODY COMPLEX, VIRAL PROTEIN, VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.JO,A.B.WARD REVDAT 1 13-AUG-25 9O4P 0 JRNL AUTH G.JO,S.YAMAYOSHI,K.M.MA,O.SWANSON,J.L.TORRES,J.A.FERGUSON, JRNL AUTH 2 M.L.FERNANDEZ-QUINTERO,J.HUANG,J.COPPS,A.J.RODRIGUEZ, JRNL AUTH 3 J.M.STEICHEN,Y.KAWAOKA,J.HAN,A.B.WARD JRNL TITL STRUCTURAL BASIS OF BROAD PROTECTION AGAINST INFLUENZA VIRUS JRNL TITL 2 BY HUMAN ANTIBODIES TARGETING THE NEURAMINIDASE ACTIVE SITE JRNL TITL 3 VIA A RECURRING MOTIF IN CDR H3. JRNL REF NAT COMMUN V. 16 7067 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 40750588 JRNL DOI 10.1038/S41467-025-62174-2 REMARK 2 REMARK 2 RESOLUTION. 2.55 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, EPU, CRYOSPARC, PHENIX, REMARK 3 CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.550 REMARK 3 NUMBER OF PARTICLES : 107490 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9O4P COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-APR-25. REMARK 100 THE DEPOSITION ID IS D_1000294754. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF AF9C-GL REMARK 245 FAB IN COMPLEX WITH INFLUENZA REMARK 245 VIRUS NEURAMINIDASE FROM A/ REMARK 245 CALIFORNIA/07/2009 (H1N1) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.40 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 3142 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1700.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4500.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -8 REMARK 465 TYR A -7 REMARK 465 SER A -6 REMARK 465 MET A -5 REMARK 465 GLN A -4 REMARK 465 LEU A -3 REMARK 465 ALA A -2 REMARK 465 SER A -1 REMARK 465 CYS A 0 REMARK 465 VAL A 1 REMARK 465 THR A 2 REMARK 465 LEU A 3 REMARK 465 THR A 4 REMARK 465 LEU A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 VAL A 9 REMARK 465 ASN A 10 REMARK 465 SER A 11 REMARK 465 GLN A 12 REMARK 465 HIS A 13 REMARK 465 HIS A 14 REMARK 465 HIS A 15 REMARK 465 HIS A 16 REMARK 465 HIS A 17 REMARK 465 HIS A 18 REMARK 465 GLY A 19 REMARK 465 SER A 20 REMARK 465 ALA A 21 REMARK 465 TRP A 22 REMARK 465 SER A 23 REMARK 465 HIS A 24 REMARK 465 PRO A 25 REMARK 465 GLN A 26 REMARK 465 PHE A 27 REMARK 465 GLU A 28 REMARK 465 LYS A 29 REMARK 465 GLY A 30 REMARK 465 GLY A 31 REMARK 465 SER A 32 REMARK 465 SER A 33 REMARK 465 SER A 34 REMARK 465 ASP A 35 REMARK 465 TYR A 36 REMARK 465 SER A 37 REMARK 465 ASP A 38 REMARK 465 LEU A 39 REMARK 465 GLN A 40 REMARK 465 ARG A 41 REMARK 465 VAL A 42 REMARK 465 LYS A 43 REMARK 465 GLN A 44 REMARK 465 GLU A 45 REMARK 465 LEU A 46 REMARK 465 LEU A 47 REMARK 465 GLU A 48 REMARK 465 GLU A 49 REMARK 465 VAL A 50 REMARK 465 LYS A 51 REMARK 465 LYS A 52 REMARK 465 GLU A 53 REMARK 465 LEU A 54 REMARK 465 GLN A 55 REMARK 465 LYS A 56 REMARK 465 VAL A 57 REMARK 465 LYS A 58 REMARK 465 GLU A 59 REMARK 465 GLU A 60 REMARK 465 ILE A 61 REMARK 465 ILE A 62 REMARK 465 GLU A 63 REMARK 465 ALA A 64 REMARK 465 PHE A 65 REMARK 465 VAL A 66 REMARK 465 GLN A 67 REMARK 465 GLU A 68 REMARK 465 LEU A 69 REMARK 465 ARG A 70 REMARK 465 LYS A 71 REMARK 465 ARG A 72 REMARK 465 GLY A 73 REMARK 465 SER A 74 REMARK 465 LEU A 75 REMARK 465 VAL A 76 REMARK 465 PRO A 77 REMARK 465 ARG A 78 REMARK 465 GLY A 79 REMARK 465 SER A 80 REMARK 465 GLY A 81 REMARK 465 GLY A 82 REMARK 465 MET B -8 REMARK 465 TYR B -7 REMARK 465 SER B -6 REMARK 465 MET B -5 REMARK 465 GLN B -4 REMARK 465 LEU B -3 REMARK 465 ALA B -2 REMARK 465 SER B -1 REMARK 465 CYS B 0 REMARK 465 VAL B 1 REMARK 465 THR B 2 REMARK 465 LEU B 3 REMARK 465 THR B 4 REMARK 465 LEU B 5 REMARK 465 VAL B 6 REMARK 465 LEU B 7 REMARK 465 LEU B 8 REMARK 465 VAL B 9 REMARK 465 ASN B 10 REMARK 465 SER B 11 REMARK 465 GLN B 12 REMARK 465 HIS B 13 REMARK 465 HIS B 14 REMARK 465 HIS B 15 REMARK 465 HIS B 16 REMARK 465 HIS B 17 REMARK 465 HIS B 18 REMARK 465 GLY B 19 REMARK 465 SER B 20 REMARK 465 ALA B 21 REMARK 465 TRP B 22 REMARK 465 SER B 23 REMARK 465 HIS B 24 REMARK 465 PRO B 25 REMARK 465 GLN B 26 REMARK 465 PHE B 27 REMARK 465 GLU B 28 REMARK 465 LYS B 29 REMARK 465 GLY B 30 REMARK 465 GLY B 31 REMARK 465 SER B 32 REMARK 465 SER B 33 REMARK 465 SER B 34 REMARK 465 ASP B 35 REMARK 465 TYR B 36 REMARK 465 SER B 37 REMARK 465 ASP B 38 REMARK 465 LEU B 39 REMARK 465 GLN B 40 REMARK 465 ARG B 41 REMARK 465 VAL B 42 REMARK 465 LYS B 43 REMARK 465 GLN B 44 REMARK 465 GLU B 45 REMARK 465 LEU B 46 REMARK 465 LEU B 47 REMARK 465 GLU B 48 REMARK 465 GLU B 49 REMARK 465 VAL B 50 REMARK 465 LYS B 51 REMARK 465 LYS B 52 REMARK 465 GLU B 53 REMARK 465 LEU B 54 REMARK 465 GLN B 55 REMARK 465 LYS B 56 REMARK 465 VAL B 57 REMARK 465 LYS B 58 REMARK 465 GLU B 59 REMARK 465 GLU B 60 REMARK 465 ILE B 61 REMARK 465 ILE B 62 REMARK 465 GLU B 63 REMARK 465 ALA B 64 REMARK 465 PHE B 65 REMARK 465 VAL B 66 REMARK 465 GLN B 67 REMARK 465 GLU B 68 REMARK 465 LEU B 69 REMARK 465 ARG B 70 REMARK 465 LYS B 71 REMARK 465 ARG B 72 REMARK 465 GLY B 73 REMARK 465 SER B 74 REMARK 465 LEU B 75 REMARK 465 VAL B 76 REMARK 465 PRO B 77 REMARK 465 ARG B 78 REMARK 465 GLY B 79 REMARK 465 SER B 80 REMARK 465 GLY B 81 REMARK 465 GLY B 82 REMARK 465 MET C -8 REMARK 465 TYR C -7 REMARK 465 SER C -6 REMARK 465 MET C -5 REMARK 465 GLN C -4 REMARK 465 LEU C -3 REMARK 465 ALA C -2 REMARK 465 SER C -1 REMARK 465 CYS C 0 REMARK 465 VAL C 1 REMARK 465 THR C 2 REMARK 465 LEU C 3 REMARK 465 THR C 4 REMARK 465 LEU C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 VAL C 9 REMARK 465 ASN C 10 REMARK 465 SER C 11 REMARK 465 GLN C 12 REMARK 465 HIS C 13 REMARK 465 HIS C 14 REMARK 465 HIS C 15 REMARK 465 HIS C 16 REMARK 465 HIS C 17 REMARK 465 HIS C 18 REMARK 465 GLY C 19 REMARK 465 SER C 20 REMARK 465 ALA C 21 REMARK 465 TRP C 22 REMARK 465 SER C 23 REMARK 465 HIS C 24 REMARK 465 PRO C 25 REMARK 465 GLN C 26 REMARK 465 PHE C 27 REMARK 465 GLU C 28 REMARK 465 LYS C 29 REMARK 465 GLY C 30 REMARK 465 GLY C 31 REMARK 465 SER C 32 REMARK 465 SER C 33 REMARK 465 SER C 34 REMARK 465 ASP C 35 REMARK 465 TYR C 36 REMARK 465 SER C 37 REMARK 465 ASP C 38 REMARK 465 LEU C 39 REMARK 465 GLN C 40 REMARK 465 ARG C 41 REMARK 465 VAL C 42 REMARK 465 LYS C 43 REMARK 465 GLN C 44 REMARK 465 GLU C 45 REMARK 465 LEU C 46 REMARK 465 LEU C 47 REMARK 465 GLU C 48 REMARK 465 GLU C 49 REMARK 465 VAL C 50 REMARK 465 LYS C 51 REMARK 465 LYS C 52 REMARK 465 GLU C 53 REMARK 465 LEU C 54 REMARK 465 GLN C 55 REMARK 465 LYS C 56 REMARK 465 VAL C 57 REMARK 465 LYS C 58 REMARK 465 GLU C 59 REMARK 465 GLU C 60 REMARK 465 ILE C 61 REMARK 465 ILE C 62 REMARK 465 GLU C 63 REMARK 465 ALA C 64 REMARK 465 PHE C 65 REMARK 465 VAL C 66 REMARK 465 GLN C 67 REMARK 465 GLU C 68 REMARK 465 LEU C 69 REMARK 465 ARG C 70 REMARK 465 LYS C 71 REMARK 465 ARG C 72 REMARK 465 GLY C 73 REMARK 465 SER C 74 REMARK 465 LEU C 75 REMARK 465 VAL C 76 REMARK 465 PRO C 77 REMARK 465 ARG C 78 REMARK 465 GLY C 79 REMARK 465 SER C 80 REMARK 465 GLY C 81 REMARK 465 GLY C 82 REMARK 465 MET D -8 REMARK 465 TYR D -7 REMARK 465 SER D -6 REMARK 465 MET D -5 REMARK 465 GLN D -4 REMARK 465 LEU D -3 REMARK 465 ALA D -2 REMARK 465 SER D -1 REMARK 465 CYS D 0 REMARK 465 VAL D 1 REMARK 465 THR D 2 REMARK 465 LEU D 3 REMARK 465 THR D 4 REMARK 465 LEU D 5 REMARK 465 VAL D 6 REMARK 465 LEU D 7 REMARK 465 LEU D 8 REMARK 465 VAL D 9 REMARK 465 ASN D 10 REMARK 465 SER D 11 REMARK 465 GLN D 12 REMARK 465 HIS D 13 REMARK 465 HIS D 14 REMARK 465 HIS D 15 REMARK 465 HIS D 16 REMARK 465 HIS D 17 REMARK 465 HIS D 18 REMARK 465 GLY D 19 REMARK 465 SER D 20 REMARK 465 ALA D 21 REMARK 465 TRP D 22 REMARK 465 SER D 23 REMARK 465 HIS D 24 REMARK 465 PRO D 25 REMARK 465 GLN D 26 REMARK 465 PHE D 27 REMARK 465 GLU D 28 REMARK 465 LYS D 29 REMARK 465 GLY D 30 REMARK 465 GLY D 31 REMARK 465 SER D 32 REMARK 465 SER D 33 REMARK 465 SER D 34 REMARK 465 ASP D 35 REMARK 465 TYR D 36 REMARK 465 SER D 37 REMARK 465 ASP D 38 REMARK 465 LEU D 39 REMARK 465 GLN D 40 REMARK 465 ARG D 41 REMARK 465 VAL D 42 REMARK 465 LYS D 43 REMARK 465 GLN D 44 REMARK 465 GLU D 45 REMARK 465 LEU D 46 REMARK 465 LEU D 47 REMARK 465 GLU D 48 REMARK 465 GLU D 49 REMARK 465 VAL D 50 REMARK 465 LYS D 51 REMARK 465 LYS D 52 REMARK 465 GLU D 53 REMARK 465 LEU D 54 REMARK 465 GLN D 55 REMARK 465 LYS D 56 REMARK 465 VAL D 57 REMARK 465 LYS D 58 REMARK 465 GLU D 59 REMARK 465 GLU D 60 REMARK 465 ILE D 61 REMARK 465 ILE D 62 REMARK 465 GLU D 63 REMARK 465 ALA D 64 REMARK 465 PHE D 65 REMARK 465 VAL D 66 REMARK 465 GLN D 67 REMARK 465 GLU D 68 REMARK 465 LEU D 69 REMARK 465 ARG D 70 REMARK 465 LYS D 71 REMARK 465 ARG D 72 REMARK 465 GLY D 73 REMARK 465 SER D 74 REMARK 465 LEU D 75 REMARK 465 VAL D 76 REMARK 465 PRO D 77 REMARK 465 ARG D 78 REMARK 465 GLY D 79 REMARK 465 SER D 80 REMARK 465 GLY D 81 REMARK 465 GLY D 82 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 LYS A 470 CG CD CE NZ REMARK 470 LYS B 470 CG CD CE NZ REMARK 470 LYS C 470 CG CD CE NZ REMARK 470 LYS D 470 CG CD CE NZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER I 52 -49.83 -152.84 REMARK 500 SER J 52 -49.83 -152.84 REMARK 500 SER K 52 -49.83 -152.84 REMARK 500 SER L 52 -49.83 -152.84 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG A 156 0.17 SIDE CHAIN REMARK 500 ARG A 224 0.22 SIDE CHAIN REMARK 500 ARG B 156 0.17 SIDE CHAIN REMARK 500 ARG B 224 0.22 SIDE CHAIN REMARK 500 ARG C 156 0.17 SIDE CHAIN REMARK 500 ARG C 224 0.22 SIDE CHAIN REMARK 500 ARG D 156 0.17 SIDE CHAIN REMARK 500 ARG D 224 0.22 SIDE CHAIN REMARK 500 ARG E 100C 0.10 SIDE CHAIN REMARK 500 ARG F 100C 0.10 SIDE CHAIN REMARK 500 ARG G 100C 0.10 SIDE CHAIN REMARK 500 ARG H 100C 0.10 SIDE CHAIN REMARK 500 ARG I 103 0.12 SIDE CHAIN REMARK 500 ARG J 103 0.12 SIDE CHAIN REMARK 500 ARG K 103 0.12 SIDE CHAIN REMARK 500 ARG L 103 0.12 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA A 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP A 293 O REMARK 620 2 GLY A 297 O 88.9 REMARK 620 3 ASP A 324 OD2 96.8 87.5 REMARK 620 4 GLY A 345 O 93.1 85.1 167.5 REMARK 620 5 ASN A 347 O 124.5 146.6 86.3 94.4 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA A 502 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP A 379 OD1 REMARK 620 2 ASN A 381 OD1 93.1 REMARK 620 3 ASP A 387 OD1 106.5 69.9 REMARK 620 4 ASP A 387 OD2 160.7 75.0 55.4 REMARK 620 5 ASN A 389 O 71.2 163.7 118.0 121.3 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA B 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP B 293 O REMARK 620 2 GLY B 297 O 88.9 REMARK 620 3 ASP B 324 OD2 96.8 87.5 REMARK 620 4 GLY B 345 O 93.1 85.1 167.5 REMARK 620 5 ASN B 347 O 124.5 146.6 86.3 94.4 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA B 502 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP B 379 OD1 REMARK 620 2 ASN B 381 OD1 93.1 REMARK 620 3 ASP B 387 OD1 106.5 69.9 REMARK 620 4 ASP B 387 OD2 160.7 75.0 55.4 REMARK 620 5 ASN B 389 O 71.2 163.7 118.0 121.3 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA C 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP C 293 O REMARK 620 2 GLY C 297 O 88.9 REMARK 620 3 ASP C 324 OD2 96.8 87.5 REMARK 620 4 GLY C 345 O 93.1 85.1 167.5 REMARK 620 5 ASN C 347 O 124.5 146.6 86.3 94.4 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA C 502 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP C 379 OD1 REMARK 620 2 ASN C 381 OD1 93.1 REMARK 620 3 ASP C 387 OD1 106.5 69.9 REMARK 620 4 ASP C 387 OD2 160.7 75.0 55.4 REMARK 620 5 ASN C 389 O 71.2 163.7 118.0 121.3 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA D 501 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP D 293 O REMARK 620 2 GLY D 297 O 88.9 REMARK 620 3 ASP D 324 OD2 96.8 87.5 REMARK 620 4 GLY D 345 O 93.1 85.1 167.5 REMARK 620 5 ASN D 347 O 124.5 146.6 86.3 94.4 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA D 502 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP D 379 OD1 REMARK 620 2 ASN D 381 OD1 93.1 REMARK 620 3 ASP D 387 OD1 106.5 69.9 REMARK 620 4 ASP D 387 OD2 160.7 75.0 55.4 REMARK 620 5 ASN D 389 O 71.2 163.7 118.0 121.3 REMARK 620 N 1 2 3 4 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-70110 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF AF9C-GL FAB IN COMPLEX WITH INFLUENZA VIRUS REMARK 900 NEURAMINIDASE FROM A/CALIFORNIA/07/2009 (H1N1) DBREF 9O4P A 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9O4P B 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9O4P C 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9O4P D 83 470 UNP C7FH46 C7FH46_9INFA 83 469 DBREF 9O4P E 1 114 PDB 9O4P 9O4P 1 114 DBREF 9O4P F 1 114 PDB 9O4P 9O4P 1 114 DBREF 9O4P G 1 114 PDB 9O4P 9O4P 1 114 DBREF 9O4P H 1 114 PDB 9O4P 9O4P 1 114 DBREF 9O4P I 1 107 PDB 9O4P 9O4P 1 107 DBREF 9O4P J 1 107 PDB 9O4P 9O4P 1 107 DBREF 9O4P K 1 107 PDB 9O4P 9O4P 1 107 DBREF 9O4P L 1 107 PDB 9O4P 9O4P 1 107 SEQADV 9O4P MET A -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9O4P TYR A -7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A -6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P MET A -5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN A -4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A -3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA A -2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A -1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P CYS A 0 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR A 2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR A 4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 8 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 9 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASN A 10 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 11 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN A 12 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS A 13 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS A 14 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS A 15 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS A 16 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS A 17 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS A 18 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY A 19 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 20 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA A 21 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TRP A 22 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 23 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS A 24 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO A 25 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN A 26 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE A 27 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 28 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS A 29 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY A 30 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY A 31 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 32 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 33 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 34 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP A 35 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TYR A 36 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 37 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP A 38 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 39 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN A 40 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG A 41 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 42 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS A 43 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN A 44 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 45 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 46 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 47 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 48 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 49 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 50 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS A 51 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS A 52 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 53 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 54 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN A 55 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS A 56 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 57 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS A 58 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 59 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 60 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE A 61 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE A 62 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 63 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA A 64 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE A 65 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 66 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN A 67 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU A 68 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 69 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG A 70 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS A 71 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG A 72 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY A 73 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 74 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU A 75 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL A 76 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO A 77 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG A 78 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY A 79 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER A 80 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY A 81 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY A 82 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO A 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9O4P LEU A 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9O4P VAL A 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9O4P SER A 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9O4P ALA A 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9O4P ILE A 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9O4P THR A 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9O4P ILE A 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9O4P PHE A 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9O4P MET A 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9O4P VAL A 419 UNP C7FH46 ARG 419 CONFLICT SEQADV 9O4P MET B -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9O4P TYR B -7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B -6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P MET B -5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN B -4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B -3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA B -2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B -1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P CYS B 0 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR B 2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR B 4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 8 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 9 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASN B 10 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 11 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN B 12 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS B 13 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS B 14 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS B 15 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS B 16 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS B 17 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS B 18 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY B 19 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 20 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA B 21 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TRP B 22 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 23 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS B 24 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO B 25 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN B 26 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE B 27 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 28 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS B 29 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY B 30 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY B 31 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 32 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 33 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 34 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP B 35 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TYR B 36 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 37 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP B 38 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 39 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN B 40 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG B 41 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 42 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS B 43 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN B 44 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 45 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 46 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 47 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 48 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 49 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 50 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS B 51 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS B 52 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 53 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 54 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN B 55 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS B 56 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 57 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS B 58 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 59 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 60 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE B 61 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE B 62 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 63 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA B 64 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE B 65 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 66 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN B 67 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU B 68 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 69 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG B 70 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS B 71 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG B 72 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY B 73 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 74 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU B 75 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL B 76 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO B 77 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG B 78 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY B 79 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER B 80 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY B 81 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY B 82 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO B 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9O4P LEU B 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9O4P VAL B 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9O4P SER B 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9O4P ALA B 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9O4P ILE B 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9O4P THR B 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9O4P ILE B 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9O4P PHE B 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9O4P MET B 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9O4P VAL B 419 UNP C7FH46 ARG 419 CONFLICT SEQADV 9O4P MET C -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9O4P TYR C -7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C -6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P MET C -5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN C -4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C -3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA C -2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C -1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P CYS C 0 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR C 2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR C 4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 8 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 9 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASN C 10 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 11 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN C 12 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS C 13 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS C 14 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS C 15 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS C 16 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS C 17 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS C 18 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY C 19 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 20 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA C 21 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TRP C 22 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 23 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS C 24 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO C 25 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN C 26 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE C 27 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 28 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS C 29 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY C 30 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY C 31 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 32 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 33 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 34 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP C 35 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TYR C 36 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 37 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP C 38 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 39 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN C 40 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG C 41 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 42 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS C 43 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN C 44 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 45 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 46 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 47 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 48 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 49 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 50 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS C 51 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS C 52 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 53 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 54 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN C 55 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS C 56 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 57 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS C 58 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 59 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 60 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE C 61 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE C 62 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 63 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA C 64 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE C 65 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 66 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN C 67 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU C 68 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 69 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG C 70 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS C 71 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG C 72 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY C 73 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 74 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU C 75 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL C 76 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO C 77 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG C 78 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY C 79 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER C 80 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY C 81 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY C 82 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO C 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9O4P LEU C 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9O4P VAL C 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9O4P SER C 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9O4P ALA C 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9O4P ILE C 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9O4P THR C 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9O4P ILE C 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9O4P PHE C 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9O4P MET C 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9O4P VAL C 419 UNP C7FH46 ARG 419 CONFLICT SEQADV 9O4P MET D -8 UNP C7FH46 INITIATING METHIONINE SEQADV 9O4P TYR D -7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D -6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P MET D -5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN D -4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D -3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA D -2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D -1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P CYS D 0 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 1 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR D 2 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 3 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P THR D 4 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 5 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 6 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 7 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 8 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 9 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASN D 10 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 11 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN D 12 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS D 13 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS D 14 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS D 15 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS D 16 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS D 17 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS D 18 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY D 19 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 20 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA D 21 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TRP D 22 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 23 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P HIS D 24 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO D 25 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN D 26 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE D 27 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 28 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS D 29 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY D 30 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY D 31 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 32 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 33 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 34 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP D 35 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P TYR D 36 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 37 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ASP D 38 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 39 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN D 40 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG D 41 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 42 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS D 43 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN D 44 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 45 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 46 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 47 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 48 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 49 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 50 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS D 51 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS D 52 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 53 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 54 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN D 55 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS D 56 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 57 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS D 58 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 59 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 60 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE D 61 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ILE D 62 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 63 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ALA D 64 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PHE D 65 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 66 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLN D 67 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLU D 68 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 69 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG D 70 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LYS D 71 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG D 72 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY D 73 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 74 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P LEU D 75 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P VAL D 76 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO D 77 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P ARG D 78 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY D 79 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P SER D 80 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY D 81 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P GLY D 82 UNP C7FH46 EXPRESSION TAG SEQADV 9O4P PRO D 99 UNP C7FH46 ILE 99 CONFLICT SEQADV 9O4P LEU D 100 UNP C7FH46 TYR 100 CONFLICT SEQADV 9O4P VAL D 161 UNP C7FH46 CYS 161 CONFLICT SEQADV 9O4P SER D 165 UNP C7FH46 GLU 165 CONFLICT SEQADV 9O4P ALA D 171 UNP C7FH46 SER 172 CONFLICT SEQADV 9O4P ILE D 176 UNP C7FH46 VAL 177 CONFLICT SEQADV 9O4P THR D 195 UNP C7FH46 SER 196 CONFLICT SEQADV 9O4P ILE D 204 UNP C7FH46 VAL 205 CONFLICT SEQADV 9O4P PHE D 354 UNP C7FH46 TYR 351 CONFLICT SEQADV 9O4P MET D 412 UNP C7FH46 GLN 408 CONFLICT SEQADV 9O4P VAL D 419 UNP C7FH46 ARG 419 CONFLICT SEQRES 1 A 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 A 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 A 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 A 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 A 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 A 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 A 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 A 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 A 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 A 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 A 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 A 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 A 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 A 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 A 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 A 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 A 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 A 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 A 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 A 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 A 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 A 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 A 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 A 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 A 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 A 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 A 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 A 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 A 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 A 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 A 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 A 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 A 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 A 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 A 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 A 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 A 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 B 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 B 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 B 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 B 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 B 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 B 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 B 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 B 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 B 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 B 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 B 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 B 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 B 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 B 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 B 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 B 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 B 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 B 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 B 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 B 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 B 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 B 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 B 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 B 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 B 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 B 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 B 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 B 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 B 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 B 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 B 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 B 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 B 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 B 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 B 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 B 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 B 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 C 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 C 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 C 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 C 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 C 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 C 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 C 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 C 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 C 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 C 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 C 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 C 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 C 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 C 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 C 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 C 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 C 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 C 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 C 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 C 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 C 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 C 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 C 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 C 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 C 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 C 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 C 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 C 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 C 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 C 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 C 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 C 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 C 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 C 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 C 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 C 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 C 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 D 478 MET TYR SER MET GLN LEU ALA SER CYS VAL THR LEU THR SEQRES 2 D 478 LEU VAL LEU LEU VAL ASN SER GLN HIS HIS HIS HIS HIS SEQRES 3 D 478 HIS GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SEQRES 4 D 478 GLY SER SER SER ASP TYR SER ASP LEU GLN ARG VAL LYS SEQRES 5 D 478 GLN GLU LEU LEU GLU GLU VAL LYS LYS GLU LEU GLN LYS SEQRES 6 D 478 VAL LYS GLU GLU ILE ILE GLU ALA PHE VAL GLN GLU LEU SEQRES 7 D 478 ARG LYS ARG GLY SER LEU VAL PRO ARG GLY SER GLY GLY SEQRES 8 D 478 VAL LYS LEU ALA GLY ASN SER SER LEU CYS PRO VAL SER SEQRES 9 D 478 GLY TRP ALA PRO LEU SER LYS ASP ASN SER VAL ARG ILE SEQRES 10 D 478 GLY SER LYS GLY ASP VAL PHE VAL ILE ARG GLU PRO PHE SEQRES 11 D 478 ILE SER CYS SER PRO LEU GLU CYS ARG THR PHE PHE LEU SEQRES 12 D 478 THR GLN GLY ALA LEU LEU ASN ASP LYS HIS SER ASN GLY SEQRES 13 D 478 THR ILE LYS ASP ARG SER PRO TYR ARG THR LEU MET SER SEQRES 14 D 478 VAL PRO ILE GLY SER VAL PRO SER PRO TYR ASN ALA ARG SEQRES 15 D 478 PHE GLU SER ILE ALA TRP SER ALA SER ALA CYS HIS ASP SEQRES 16 D 478 GLY ILE ASN TRP LEU THR ILE GLY ILE THR GLY PRO ASP SEQRES 17 D 478 ASN GLY ALA VAL ALA ILE LEU LYS TYR ASN GLY ILE ILE SEQRES 18 D 478 THR ASP THR ILE LYS SER TRP ARG ASN ASN ILE LEU ARG SEQRES 19 D 478 THR GLN GLU SER GLU CYS ALA CYS VAL ASN GLY SER CYS SEQRES 20 D 478 PHE THR VAL MET THR ASP GLY PRO SER ASN GLY GLN ALA SEQRES 21 D 478 SER TYR LYS ILE PHE ARG ILE GLU LYS GLY LYS ILE VAL SEQRES 22 D 478 LYS SER VAL GLU MET ASN ALA PRO ASN TYR HIS TYR GLU SEQRES 23 D 478 GLU CYS SER CYS TYR PRO ASP SER SER GLU ILE THR CYS SEQRES 24 D 478 VAL CYS ARG ASP ASN TRP HIS GLY SER ASN ARG PRO TRP SEQRES 25 D 478 VAL SER PHE ASN GLN ASN LEU GLU TYR GLN ILE GLY TYR SEQRES 26 D 478 ILE CYS SER GLY ILE PHE GLY ASP ASN PRO ARG PRO ASN SEQRES 27 D 478 ASP LYS THR GLY SER CYS GLY PRO VAL SER SER ASN GLY SEQRES 28 D 478 ALA ASN GLY VAL LYS GLY PHE SER PHE LYS TYR GLY ASN SEQRES 29 D 478 GLY VAL TRP ILE GLY ARG THR LYS SER ILE SER SER ARG SEQRES 30 D 478 ASN GLY PHE GLU MET ILE TRP ASP PRO ASN GLY TRP THR SEQRES 31 D 478 GLY THR ASP ASN ASN PHE SER ILE LYS GLN ASP ILE VAL SEQRES 32 D 478 GLY ILE ASN GLU TRP SER GLY TYR SER GLY SER PHE VAL SEQRES 33 D 478 MET HIS PRO GLU LEU THR GLY LEU ASP CYS ILE VAL PRO SEQRES 34 D 478 CYS PHE TRP VAL GLU LEU ILE ARG GLY ARG PRO LYS GLU SEQRES 35 D 478 ASN THR ILE TRP THR SER GLY SER SER ILE SER PHE CYS SEQRES 36 D 478 GLY VAL ASN SER ASP THR VAL GLY TRP SER TRP PRO ASP SEQRES 37 D 478 GLY ALA GLU LEU PRO PHE THR ILE ASP LYS SEQRES 1 E 126 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 E 126 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 E 126 GLY THR PHE SER SER TYR ALA ILE SER TRP VAL ARG GLN SEQRES 4 E 126 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE ILE SEQRES 5 E 126 PRO ILE PHE GLY THR ALA ASN TYR ALA GLN LYS PHE GLN SEQRES 6 E 126 GLY ARG VAL THR ILE THR ALA ASP GLU SER THR SER THR SEQRES 7 E 126 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 E 126 ALA VAL TYR TYR CYS ALA ARG ASP LEU ALA PRO TYR GLY SEQRES 9 E 126 ASP ARG PHE TYR PHE HIS TYR GLY MET ASP VAL TRP GLY SEQRES 10 E 126 GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 F 126 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 F 126 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 F 126 GLY THR PHE SER SER TYR ALA ILE SER TRP VAL ARG GLN SEQRES 4 F 126 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE ILE SEQRES 5 F 126 PRO ILE PHE GLY THR ALA ASN TYR ALA GLN LYS PHE GLN SEQRES 6 F 126 GLY ARG VAL THR ILE THR ALA ASP GLU SER THR SER THR SEQRES 7 F 126 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 F 126 ALA VAL TYR TYR CYS ALA ARG ASP LEU ALA PRO TYR GLY SEQRES 9 F 126 ASP ARG PHE TYR PHE HIS TYR GLY MET ASP VAL TRP GLY SEQRES 10 F 126 GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 G 126 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 G 126 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 G 126 GLY THR PHE SER SER TYR ALA ILE SER TRP VAL ARG GLN SEQRES 4 G 126 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE ILE SEQRES 5 G 126 PRO ILE PHE GLY THR ALA ASN TYR ALA GLN LYS PHE GLN SEQRES 6 G 126 GLY ARG VAL THR ILE THR ALA ASP GLU SER THR SER THR SEQRES 7 G 126 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 G 126 ALA VAL TYR TYR CYS ALA ARG ASP LEU ALA PRO TYR GLY SEQRES 9 G 126 ASP ARG PHE TYR PHE HIS TYR GLY MET ASP VAL TRP GLY SEQRES 10 G 126 GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 H 126 GLN VAL GLN LEU VAL GLN SER GLY ALA GLU VAL LYS LYS SEQRES 2 H 126 PRO GLY SER SER VAL LYS VAL SER CYS LYS ALA SER GLY SEQRES 3 H 126 GLY THR PHE SER SER TYR ALA ILE SER TRP VAL ARG GLN SEQRES 4 H 126 ALA PRO GLY GLN GLY LEU GLU TRP MET GLY GLY ILE ILE SEQRES 5 H 126 PRO ILE PHE GLY THR ALA ASN TYR ALA GLN LYS PHE GLN SEQRES 6 H 126 GLY ARG VAL THR ILE THR ALA ASP GLU SER THR SER THR SEQRES 7 H 126 ALA TYR MET GLU LEU SER SER LEU ARG SER GLU ASP THR SEQRES 8 H 126 ALA VAL TYR TYR CYS ALA ARG ASP LEU ALA PRO TYR GLY SEQRES 9 H 126 ASP ARG PHE TYR PHE HIS TYR GLY MET ASP VAL TRP GLY SEQRES 10 H 126 GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 I 107 ASP ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SEQRES 2 I 107 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 I 107 GLN GLY ILE SER SER TYR LEU ALA TRP TYR GLN GLN LYS SEQRES 4 I 107 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 I 107 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 I 107 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 I 107 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN LEU SEQRES 8 I 107 ASN ASN TYR PRO PHE THR PHE GLY GLN GLY THR ARG LEU SEQRES 9 I 107 GLU ILE LYS SEQRES 1 J 107 ASP ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SEQRES 2 J 107 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 J 107 GLN GLY ILE SER SER TYR LEU ALA TRP TYR GLN GLN LYS SEQRES 4 J 107 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 J 107 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 J 107 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 J 107 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN LEU SEQRES 8 J 107 ASN ASN TYR PRO PHE THR PHE GLY GLN GLY THR ARG LEU SEQRES 9 J 107 GLU ILE LYS SEQRES 1 K 107 ASP ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SEQRES 2 K 107 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 K 107 GLN GLY ILE SER SER TYR LEU ALA TRP TYR GLN GLN LYS SEQRES 4 K 107 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 K 107 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 K 107 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 K 107 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN LEU SEQRES 8 K 107 ASN ASN TYR PRO PHE THR PHE GLY GLN GLY THR ARG LEU SEQRES 9 K 107 GLU ILE LYS SEQRES 1 L 107 ASP ILE GLN LEU THR GLN SER PRO SER PHE LEU SER ALA SEQRES 2 L 107 SER VAL GLY ASP ARG VAL THR ILE THR CYS ARG ALA SER SEQRES 3 L 107 GLN GLY ILE SER SER TYR LEU ALA TRP TYR GLN GLN LYS SEQRES 4 L 107 PRO GLY LYS ALA PRO LYS LEU LEU ILE TYR ALA ALA SER SEQRES 5 L 107 THR LEU GLN SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 107 GLY SER GLY THR GLU PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 107 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN LEU SEQRES 8 L 107 ASN ASN TYR PRO PHE THR PHE GLY GLN GLY THR ARG LEU SEQRES 9 L 107 GLU ILE LYS HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET MAN O 4 11 HET MAN O 5 11 HET FUC O 6 10 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET BMA R 3 11 HET MAN R 4 11 HET MAN R 5 11 HET FUC R 6 10 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET FUC U 6 10 HET NAG V 1 14 HET NAG V 2 14 HET NAG W 1 14 HET NAG W 2 14 HET NAG X 1 14 HET NAG X 2 14 HET BMA X 3 11 HET MAN X 4 11 HET MAN X 5 11 HET FUC X 6 10 HET CA A 501 1 HET CA A 502 1 HET CA A 503 1 HET CA B 501 1 HET CA B 502 1 HET CA C 501 1 HET CA C 502 1 HET CA D 501 1 HET CA D 502 1 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETNAM FUC ALPHA-L-FUCOPYRANOSE HETNAM CA CALCIUM ION HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN FUC ALPHA-L-FUCOSE; 6-DEOXY-ALPHA-L-GALACTOPYRANOSE; L- HETSYN 2 FUC FUCOSE; FUCOSE FORMUL 13 NAG 24(C8 H15 N O6) FORMUL 15 BMA 4(C6 H12 O6) FORMUL 15 MAN 8(C6 H12 O6) FORMUL 15 FUC 4(C6 H12 O5) FORMUL 25 CA 9(CA 2+) HELIX 1 AA1 ASN A 104 SER A 110 1 7 HELIX 2 AA2 ASP A 142 ASN A 146 5 5 HELIX 3 AA3 HIS A 412A GLY A 414 1 6 HELIX 4 AA4 ASN B 104 SER B 110 1 7 HELIX 5 AA5 ASP B 142 ASN B 146 5 5 HELIX 6 AA6 HIS B 412A GLY B 414 1 6 HELIX 7 AA7 ASN C 104 SER C 110 1 7 HELIX 8 AA8 ASP C 142 ASN C 146 5 5 HELIX 9 AA9 HIS C 412A GLY C 414 1 6 HELIX 10 AB1 ASN D 104 SER D 110 1 7 HELIX 11 AB2 ASP D 142 ASN D 146 5 5 HELIX 12 AB3 HIS D 412A GLY D 414 1 6 HELIX 13 AB4 ARG E 83 THR E 87 5 5 HELIX 14 AB5 ARG F 83 THR F 87 5 5 HELIX 15 AB6 ARG G 83 THR G 87 5 5 HELIX 16 AB7 ARG H 83 THR H 87 5 5 SHEET 1 AA1 4 GLY A 96 LYS A 102 0 SHEET 2 AA1 4 SER A 440 VAL A 449 -1 O VAL A 449 N GLY A 96 SHEET 3 AA1 4 VAL A 419 ARG A 428 -1 N PHE A 422 O PHE A 446 SHEET 4 AA1 4 SER A 407 MET A 412 -1 N GLY A 408 O TRP A 423 SHEET 1 AA2 4 PHE A 115 CYS A 124 0 SHEET 2 AA2 4 CYS A 129 LEU A 139 -1 O PHE A 132 N PHE A 121 SHEET 3 AA2 4 THR A 157 PRO A 162 -1 O THR A 157 N THR A 135 SHEET 4 AA2 4 ARG A 172 ILE A 176 -1 O SER A 175 N LEU A 158 SHEET 1 AA3 4 SER A 179 HIS A 184 0 SHEET 2 AA3 4 TRP A 189 THR A 195 -1 O LEU A 190 N CYS A 183 SHEET 3 AA3 4 VAL A 202 TYR A 207 -1 O LYS A 206 N THR A 191 SHEET 4 AA3 4 ILE A 210 LYS A 216 -1 O ILE A 215 N ALA A 203 SHEET 1 AA4 3 LEU A 223 ARG A 224 0 SHEET 2 AA4 3 SER A 236 ASP A 243 -1 O THR A 242 N ARG A 224 SHEET 3 AA4 3 ALA A 231 VAL A 233 -1 N VAL A 233 O SER A 236 SHEET 1 AA5 4 LEU A 223 ARG A 224 0 SHEET 2 AA5 4 SER A 236 ASP A 243 -1 O THR A 242 N ARG A 224 SHEET 3 AA5 4 SER A 251 GLU A 258 -1 O ILE A 257 N CYS A 237 SHEET 4 AA5 4 LYS A 261 MET A 268 -1 O MET A 268 N TYR A 252 SHEET 1 AA6 4 GLU A 276 ASP A 283 0 SHEET 2 AA6 4 GLU A 286 ARG A 292 -1 O ARG A 292 N GLU A 276 SHEET 3 AA6 4 PRO A 301 PHE A 305 -1 O VAL A 303 N CYS A 289 SHEET 4 AA6 4 TYR A 312 TYR A 316 -1 O GLY A 315 N TRP A 302 SHEET 1 AA7 4 SER A 353 TYR A 356 0 SHEET 2 AA7 4 GLY A 359 ARG A 364 -1 O GLY A 359 N TYR A 356 SHEET 3 AA7 4 ASN A 372 ASP A 379 -1 O ILE A 377 N ILE A 362 SHEET 4 AA7 4 ILE A 392 TRP A 403 -1 O GLN A 395 N MET A 376 SHEET 1 AA8 4 GLY B 96 LYS B 102 0 SHEET 2 AA8 4 SER B 440 VAL B 449 -1 O VAL B 449 N GLY B 96 SHEET 3 AA8 4 VAL B 419 ARG B 428 -1 N PHE B 422 O PHE B 446 SHEET 4 AA8 4 SER B 407 MET B 412 -1 N GLY B 408 O TRP B 423 SHEET 1 AA9 4 PHE B 115 CYS B 124 0 SHEET 2 AA9 4 CYS B 129 LEU B 139 -1 O PHE B 132 N PHE B 121 SHEET 3 AA9 4 THR B 157 PRO B 162 -1 O THR B 157 N THR B 135 SHEET 4 AA9 4 ARG B 172 ILE B 176 -1 O SER B 175 N LEU B 158 SHEET 1 AB1 4 SER B 179 HIS B 184 0 SHEET 2 AB1 4 TRP B 189 THR B 195 -1 O LEU B 190 N CYS B 183 SHEET 3 AB1 4 VAL B 202 TYR B 207 -1 O LYS B 206 N THR B 191 SHEET 4 AB1 4 ILE B 210 LYS B 216 -1 O ILE B 215 N ALA B 203 SHEET 1 AB2 3 LEU B 223 ARG B 224 0 SHEET 2 AB2 3 SER B 236 ASP B 243 -1 O THR B 242 N ARG B 224 SHEET 3 AB2 3 ALA B 231 VAL B 233 -1 N VAL B 233 O SER B 236 SHEET 1 AB3 4 LEU B 223 ARG B 224 0 SHEET 2 AB3 4 SER B 236 ASP B 243 -1 O THR B 242 N ARG B 224 SHEET 3 AB3 4 SER B 251 GLU B 258 -1 O ILE B 257 N CYS B 237 SHEET 4 AB3 4 LYS B 261 MET B 268 -1 O MET B 268 N TYR B 252 SHEET 1 AB4 4 GLU B 276 ASP B 283 0 SHEET 2 AB4 4 GLU B 286 ARG B 292 -1 O ARG B 292 N GLU B 276 SHEET 3 AB4 4 PRO B 301 PHE B 305 -1 O VAL B 303 N CYS B 289 SHEET 4 AB4 4 TYR B 312 TYR B 316 -1 O GLY B 315 N TRP B 302 SHEET 1 AB5 4 SER B 353 TYR B 356 0 SHEET 2 AB5 4 GLY B 359 ARG B 364 -1 O GLY B 359 N TYR B 356 SHEET 3 AB5 4 ASN B 372 ASP B 379 -1 O ILE B 377 N ILE B 362 SHEET 4 AB5 4 ILE B 392 TRP B 403 -1 O GLN B 395 N MET B 376 SHEET 1 AB6 4 GLY C 96 LYS C 102 0 SHEET 2 AB6 4 SER C 440 VAL C 449 -1 O VAL C 449 N GLY C 96 SHEET 3 AB6 4 VAL C 419 ARG C 428 -1 N PHE C 422 O PHE C 446 SHEET 4 AB6 4 SER C 407 MET C 412 -1 N GLY C 408 O TRP C 423 SHEET 1 AB7 4 PHE C 115 CYS C 124 0 SHEET 2 AB7 4 CYS C 129 LEU C 139 -1 O PHE C 132 N PHE C 121 SHEET 3 AB7 4 THR C 157 PRO C 162 -1 O THR C 157 N THR C 135 SHEET 4 AB7 4 ARG C 172 ILE C 176 -1 O SER C 175 N LEU C 158 SHEET 1 AB8 4 SER C 179 HIS C 184 0 SHEET 2 AB8 4 TRP C 189 THR C 195 -1 O LEU C 190 N CYS C 183 SHEET 3 AB8 4 VAL C 202 TYR C 207 -1 O LYS C 206 N THR C 191 SHEET 4 AB8 4 ILE C 210 LYS C 216 -1 O ILE C 215 N ALA C 203 SHEET 1 AB9 3 LEU C 223 ARG C 224 0 SHEET 2 AB9 3 SER C 236 ASP C 243 -1 O THR C 242 N ARG C 224 SHEET 3 AB9 3 ALA C 231 VAL C 233 -1 N VAL C 233 O SER C 236 SHEET 1 AC1 4 LEU C 223 ARG C 224 0 SHEET 2 AC1 4 SER C 236 ASP C 243 -1 O THR C 242 N ARG C 224 SHEET 3 AC1 4 SER C 251 GLU C 258 -1 O ILE C 257 N CYS C 237 SHEET 4 AC1 4 LYS C 261 MET C 268 -1 O MET C 268 N TYR C 252 SHEET 1 AC2 4 GLU C 276 ASP C 283 0 SHEET 2 AC2 4 GLU C 286 ARG C 292 -1 O ARG C 292 N GLU C 276 SHEET 3 AC2 4 PRO C 301 PHE C 305 -1 O VAL C 303 N CYS C 289 SHEET 4 AC2 4 TYR C 312 TYR C 316 -1 O GLY C 315 N TRP C 302 SHEET 1 AC3 4 SER C 353 TYR C 356 0 SHEET 2 AC3 4 GLY C 359 ARG C 364 -1 O GLY C 359 N TYR C 356 SHEET 3 AC3 4 ASN C 372 ASP C 379 -1 O ILE C 377 N ILE C 362 SHEET 4 AC3 4 ILE C 392 TRP C 403 -1 O GLN C 395 N MET C 376 SHEET 1 AC4 4 GLY D 96 LYS D 102 0 SHEET 2 AC4 4 SER D 440 VAL D 449 -1 O VAL D 449 N GLY D 96 SHEET 3 AC4 4 VAL D 419 ARG D 428 -1 N PHE D 422 O PHE D 446 SHEET 4 AC4 4 SER D 407 MET D 412 -1 N GLY D 408 O TRP D 423 SHEET 1 AC5 4 PHE D 115 CYS D 124 0 SHEET 2 AC5 4 CYS D 129 LEU D 139 -1 O PHE D 132 N PHE D 121 SHEET 3 AC5 4 THR D 157 PRO D 162 -1 O THR D 157 N THR D 135 SHEET 4 AC5 4 ARG D 172 ILE D 176 -1 O SER D 175 N LEU D 158 SHEET 1 AC6 4 SER D 179 HIS D 184 0 SHEET 2 AC6 4 TRP D 189 THR D 195 -1 O LEU D 190 N CYS D 183 SHEET 3 AC6 4 VAL D 202 TYR D 207 -1 O LYS D 206 N THR D 191 SHEET 4 AC6 4 ILE D 210 LYS D 216 -1 O ILE D 215 N ALA D 203 SHEET 1 AC7 3 LEU D 223 ARG D 224 0 SHEET 2 AC7 3 SER D 236 ASP D 243 -1 O THR D 242 N ARG D 224 SHEET 3 AC7 3 ALA D 231 VAL D 233 -1 N VAL D 233 O SER D 236 SHEET 1 AC8 4 LEU D 223 ARG D 224 0 SHEET 2 AC8 4 SER D 236 ASP D 243 -1 O THR D 242 N ARG D 224 SHEET 3 AC8 4 SER D 251 GLU D 258 -1 O ILE D 257 N CYS D 237 SHEET 4 AC8 4 LYS D 261 MET D 268 -1 O MET D 268 N TYR D 252 SHEET 1 AC9 4 GLU D 276 ASP D 283 0 SHEET 2 AC9 4 GLU D 286 ARG D 292 -1 O ARG D 292 N GLU D 276 SHEET 3 AC9 4 PRO D 301 PHE D 305 -1 O VAL D 303 N CYS D 289 SHEET 4 AC9 4 TYR D 312 TYR D 316 -1 O GLY D 315 N TRP D 302 SHEET 1 AD1 4 SER D 353 TYR D 356 0 SHEET 2 AD1 4 GLY D 359 ARG D 364 -1 O GLY D 359 N TYR D 356 SHEET 3 AD1 4 ASN D 372 ASP D 379 -1 O ILE D 377 N ILE D 362 SHEET 4 AD1 4 ILE D 392 TRP D 403 -1 O GLN D 395 N MET D 376 SHEET 1 AD2 4 GLN E 3 GLN E 6 0 SHEET 2 AD2 4 VAL E 18 SER E 25 -1 O LYS E 23 N VAL E 5 SHEET 3 AD2 4 THR E 77 LEU E 82 -1 O ALA E 78 N CYS E 22 SHEET 4 AD2 4 VAL E 67 ASP E 72 -1 N THR E 68 O GLU E 81 SHEET 1 AD3 6 GLU E 10 LYS E 12 0 SHEET 2 AD3 6 THR E 108 VAL E 112 1 O THR E 111 N LYS E 12 SHEET 3 AD3 6 ALA E 88 ASP E 96 -1 N TYR E 90 O THR E 108 SHEET 4 AD3 6 ILE E 34 GLN E 39 -1 N VAL E 37 O TYR E 91 SHEET 5 AD3 6 LEU E 45 ILE E 51 -1 O GLY E 49 N TRP E 36 SHEET 6 AD3 6 ALA E 57 TYR E 59 -1 O ASN E 58 N GLY E 50 SHEET 1 AD4 4 GLU E 10 LYS E 12 0 SHEET 2 AD4 4 THR E 108 VAL E 112 1 O THR E 111 N LYS E 12 SHEET 3 AD4 4 ALA E 88 ASP E 96 -1 N TYR E 90 O THR E 108 SHEET 4 AD4 4 MET E 101 TRP E 104 -1 O VAL E 103 N ARG E 95 SHEET 1 AD5 4 GLN F 3 GLN F 6 0 SHEET 2 AD5 4 VAL F 18 SER F 25 -1 O LYS F 23 N VAL F 5 SHEET 3 AD5 4 THR F 77 LEU F 82 -1 O ALA F 78 N CYS F 22 SHEET 4 AD5 4 VAL F 67 ASP F 72 -1 N THR F 68 O GLU F 81 SHEET 1 AD6 6 GLU F 10 LYS F 12 0 SHEET 2 AD6 6 THR F 108 VAL F 112 1 O THR F 111 N LYS F 12 SHEET 3 AD6 6 ALA F 88 ASP F 96 -1 N TYR F 90 O THR F 108 SHEET 4 AD6 6 ILE F 34 GLN F 39 -1 N VAL F 37 O TYR F 91 SHEET 5 AD6 6 LEU F 45 ILE F 51 -1 O GLY F 49 N TRP F 36 SHEET 6 AD6 6 ALA F 57 TYR F 59 -1 O ASN F 58 N GLY F 50 SHEET 1 AD7 4 GLU F 10 LYS F 12 0 SHEET 2 AD7 4 THR F 108 VAL F 112 1 O THR F 111 N LYS F 12 SHEET 3 AD7 4 ALA F 88 ASP F 96 -1 N TYR F 90 O THR F 108 SHEET 4 AD7 4 MET F 101 TRP F 104 -1 O VAL F 103 N ARG F 95 SHEET 1 AD8 4 GLN G 3 GLN G 6 0 SHEET 2 AD8 4 VAL G 18 SER G 25 -1 O LYS G 23 N VAL G 5 SHEET 3 AD8 4 THR G 77 LEU G 82 -1 O ALA G 78 N CYS G 22 SHEET 4 AD8 4 VAL G 67 ASP G 72 -1 N THR G 68 O GLU G 81 SHEET 1 AD9 6 GLU G 10 LYS G 12 0 SHEET 2 AD9 6 THR G 108 VAL G 112 1 O THR G 111 N LYS G 12 SHEET 3 AD9 6 ALA G 88 ASP G 96 -1 N TYR G 90 O THR G 108 SHEET 4 AD9 6 ILE G 34 GLN G 39 -1 N VAL G 37 O TYR G 91 SHEET 5 AD9 6 LEU G 45 ILE G 51 -1 O GLY G 49 N TRP G 36 SHEET 6 AD9 6 ALA G 57 TYR G 59 -1 O ASN G 58 N GLY G 50 SHEET 1 AE1 4 GLU G 10 LYS G 12 0 SHEET 2 AE1 4 THR G 108 VAL G 112 1 O THR G 111 N LYS G 12 SHEET 3 AE1 4 ALA G 88 ASP G 96 -1 N TYR G 90 O THR G 108 SHEET 4 AE1 4 MET G 101 TRP G 104 -1 O VAL G 103 N ARG G 95 SHEET 1 AE2 4 GLN H 3 GLN H 6 0 SHEET 2 AE2 4 VAL H 18 SER H 25 -1 O LYS H 23 N VAL H 5 SHEET 3 AE2 4 THR H 77 LEU H 82 -1 O ALA H 78 N CYS H 22 SHEET 4 AE2 4 VAL H 67 ASP H 72 -1 N THR H 68 O GLU H 81 SHEET 1 AE3 6 GLU H 10 LYS H 12 0 SHEET 2 AE3 6 THR H 108 VAL H 112 1 O THR H 111 N LYS H 12 SHEET 3 AE3 6 ALA H 88 ASP H 96 -1 N TYR H 90 O THR H 108 SHEET 4 AE3 6 ILE H 34 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AE3 6 LEU H 45 ILE H 51 -1 O GLY H 49 N TRP H 36 SHEET 6 AE3 6 ALA H 57 TYR H 59 -1 O ASN H 58 N GLY H 50 SHEET 1 AE4 4 GLU H 10 LYS H 12 0 SHEET 2 AE4 4 THR H 108 VAL H 112 1 O THR H 111 N LYS H 12 SHEET 3 AE4 4 ALA H 88 ASP H 96 -1 N TYR H 90 O THR H 108 SHEET 4 AE4 4 MET H 101 TRP H 104 -1 O VAL H 103 N ARG H 95 SHEET 1 AE5 4 LEU I 4 SER I 7 0 SHEET 2 AE5 4 VAL I 19 ALA I 25 -1 O ARG I 24 N THR I 5 SHEET 3 AE5 4 GLU I 70 ILE I 75 -1 O LEU I 73 N ILE I 21 SHEET 4 AE5 4 PHE I 62 SER I 65 -1 N SER I 63 O THR I 74 SHEET 1 AE6 6 PHE I 10 SER I 12 0 SHEET 2 AE6 6 THR I 102 GLU I 105 1 O ARG I 103 N LEU I 11 SHEET 3 AE6 6 THR I 85 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AE6 6 ALA I 34 GLN I 38 -1 N TYR I 36 O TYR I 87 SHEET 5 AE6 6 LYS I 45 TYR I 49 -1 O LYS I 45 N GLN I 37 SHEET 6 AE6 6 THR I 53 LEU I 54 -1 O THR I 53 N TYR I 49 SHEET 1 AE7 4 PHE I 10 SER I 12 0 SHEET 2 AE7 4 THR I 102 GLU I 105 1 O ARG I 103 N LEU I 11 SHEET 3 AE7 4 THR I 85 GLN I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AE7 4 THR I 97 PHE I 98 -1 O THR I 97 N GLN I 90 SHEET 1 AE8 4 LEU J 4 SER J 7 0 SHEET 2 AE8 4 VAL J 19 ALA J 25 -1 O ARG J 24 N THR J 5 SHEET 3 AE8 4 GLU J 70 ILE J 75 -1 O LEU J 73 N ILE J 21 SHEET 4 AE8 4 PHE J 62 SER J 65 -1 N SER J 63 O THR J 74 SHEET 1 AE9 6 PHE J 10 SER J 12 0 SHEET 2 AE9 6 THR J 102 GLU J 105 1 O ARG J 103 N LEU J 11 SHEET 3 AE9 6 THR J 85 GLN J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AE9 6 ALA J 34 GLN J 38 -1 N TYR J 36 O TYR J 87 SHEET 5 AE9 6 LYS J 45 TYR J 49 -1 O LYS J 45 N GLN J 37 SHEET 6 AE9 6 THR J 53 LEU J 54 -1 O THR J 53 N TYR J 49 SHEET 1 AF1 4 PHE J 10 SER J 12 0 SHEET 2 AF1 4 THR J 102 GLU J 105 1 O ARG J 103 N LEU J 11 SHEET 3 AF1 4 THR J 85 GLN J 90 -1 N TYR J 86 O THR J 102 SHEET 4 AF1 4 THR J 97 PHE J 98 -1 O THR J 97 N GLN J 90 SHEET 1 AF2 4 LEU K 4 SER K 7 0 SHEET 2 AF2 4 VAL K 19 ALA K 25 -1 O ARG K 24 N THR K 5 SHEET 3 AF2 4 GLU K 70 ILE K 75 -1 O LEU K 73 N ILE K 21 SHEET 4 AF2 4 PHE K 62 SER K 65 -1 N SER K 63 O THR K 74 SHEET 1 AF3 6 PHE K 10 SER K 12 0 SHEET 2 AF3 6 THR K 102 GLU K 105 1 O ARG K 103 N LEU K 11 SHEET 3 AF3 6 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AF3 6 ALA K 34 GLN K 38 -1 N TYR K 36 O TYR K 87 SHEET 5 AF3 6 LYS K 45 TYR K 49 -1 O LYS K 45 N GLN K 37 SHEET 6 AF3 6 THR K 53 LEU K 54 -1 O THR K 53 N TYR K 49 SHEET 1 AF4 4 PHE K 10 SER K 12 0 SHEET 2 AF4 4 THR K 102 GLU K 105 1 O ARG K 103 N LEU K 11 SHEET 3 AF4 4 THR K 85 GLN K 90 -1 N TYR K 86 O THR K 102 SHEET 4 AF4 4 THR K 97 PHE K 98 -1 O THR K 97 N GLN K 90 SHEET 1 AF5 4 LEU L 4 SER L 7 0 SHEET 2 AF5 4 VAL L 19 ALA L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AF5 4 GLU L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AF5 4 PHE L 62 SER L 65 -1 N SER L 63 O THR L 74 SHEET 1 AF6 6 PHE L 10 SER L 12 0 SHEET 2 AF6 6 THR L 102 GLU L 105 1 O ARG L 103 N LEU L 11 SHEET 3 AF6 6 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AF6 6 ALA L 34 GLN L 38 -1 N TYR L 36 O TYR L 87 SHEET 5 AF6 6 LYS L 45 TYR L 49 -1 O LYS L 45 N GLN L 37 SHEET 6 AF6 6 THR L 53 LEU L 54 -1 O THR L 53 N TYR L 49 SHEET 1 AF7 4 PHE L 10 SER L 12 0 SHEET 2 AF7 4 THR L 102 GLU L 105 1 O ARG L 103 N LEU L 11 SHEET 3 AF7 4 THR L 85 GLN L 90 -1 N TYR L 86 O THR L 102 SHEET 4 AF7 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SSBOND 1 CYS A 92 CYS A 417 1555 1555 2.03 SSBOND 2 CYS A 124 CYS A 129 1555 1555 2.04 SSBOND 3 CYS A 183 CYS A 230 1555 1555 2.04 SSBOND 4 CYS A 232 CYS A 237 1555 1555 2.04 SSBOND 5 CYS A 278 CYS A 291 1555 1555 2.03 SSBOND 6 CYS A 280 CYS A 289 1555 1555 2.03 SSBOND 7 CYS A 318 CYS A 336 1555 1555 2.04 SSBOND 8 CYS A 421 CYS A 447 1555 1555 2.03 SSBOND 9 CYS B 92 CYS B 417 1555 1555 2.03 SSBOND 10 CYS B 124 CYS B 129 1555 1555 2.04 SSBOND 11 CYS B 183 CYS B 230 1555 1555 2.04 SSBOND 12 CYS B 232 CYS B 237 1555 1555 2.04 SSBOND 13 CYS B 278 CYS B 291 1555 1555 2.03 SSBOND 14 CYS B 280 CYS B 289 1555 1555 2.03 SSBOND 15 CYS B 318 CYS B 336 1555 1555 2.04 SSBOND 16 CYS B 421 CYS B 447 1555 1555 2.03 SSBOND 17 CYS C 92 CYS C 417 1555 1555 2.03 SSBOND 18 CYS C 124 CYS C 129 1555 1555 2.04 SSBOND 19 CYS C 183 CYS C 230 1555 1555 2.04 SSBOND 20 CYS C 232 CYS C 237 1555 1555 2.04 SSBOND 21 CYS C 278 CYS C 291 1555 1555 2.03 SSBOND 22 CYS C 280 CYS C 289 1555 1555 2.03 SSBOND 23 CYS C 318 CYS C 336 1555 1555 2.04 SSBOND 24 CYS C 421 CYS C 447 1555 1555 2.03 SSBOND 25 CYS D 92 CYS D 417 1555 1555 2.03 SSBOND 26 CYS D 124 CYS D 129 1555 1555 2.04 SSBOND 27 CYS D 183 CYS D 230 1555 1555 2.04 SSBOND 28 CYS D 232 CYS D 237 1555 1555 2.04 SSBOND 29 CYS D 278 CYS D 291 1555 1555 2.03 SSBOND 30 CYS D 280 CYS D 289 1555 1555 2.03 SSBOND 31 CYS D 318 CYS D 336 1555 1555 2.04 SSBOND 32 CYS D 421 CYS D 447 1555 1555 2.03 SSBOND 33 CYS E 22 CYS E 93 1555 1555 2.03 SSBOND 34 CYS F 22 CYS F 93 1555 1555 2.03 SSBOND 35 CYS G 22 CYS G 93 1555 1555 2.03 SSBOND 36 CYS H 22 CYS H 93 1555 1555 2.03 SSBOND 37 CYS I 23 CYS I 88 1555 1555 2.04 SSBOND 38 CYS J 23 CYS J 88 1555 1555 2.04 SSBOND 39 CYS K 23 CYS K 88 1555 1555 2.04 SSBOND 40 CYS L 23 CYS L 88 1555 1555 2.04 LINK ND2 ASN A 88 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN A 146 C1 NAG O 1 1555 1555 1.43 LINK ND2 ASN A 234 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN B 88 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN B 146 C1 NAG R 1 1555 1555 1.43 LINK ND2 ASN B 234 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN C 88 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN C 146 C1 NAG U 1 1555 1555 1.43 LINK ND2 ASN C 234 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN D 88 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN D 146 C1 NAG X 1 1555 1555 1.43 LINK ND2 ASN D 234 C1 NAG W 1 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.46 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.45 LINK O6 NAG O 1 C1 FUC O 6 1555 1555 1.45 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.46 LINK O3 BMA O 3 C1 MAN O 4 1555 1555 1.45 LINK O6 BMA O 3 C1 MAN O 5 1555 1555 1.45 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.46 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.45 LINK O6 NAG R 1 C1 FUC R 6 1555 1555 1.45 LINK O4 NAG R 2 C1 BMA R 3 1555 1555 1.46 LINK O3 BMA R 3 C1 MAN R 4 1555 1555 1.45 LINK O6 BMA R 3 C1 MAN R 5 1555 1555 1.45 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.46 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.45 LINK O6 NAG U 1 C1 FUC U 6 1555 1555 1.45 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.46 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.45 LINK O6 BMA U 3 C1 MAN U 5 1555 1555 1.45 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.46 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.45 LINK O6 NAG X 1 C1 FUC X 6 1555 1555 1.45 LINK O4 NAG X 2 C1 BMA X 3 1555 1555 1.46 LINK O3 BMA X 3 C1 MAN X 4 1555 1555 1.45 LINK O6 BMA X 3 C1 MAN X 5 1555 1555 1.45 LINK O ASP A 293 CA CA A 501 1555 1555 2.25 LINK O GLY A 297 CA CA A 501 1555 1555 2.23 LINK OD2 ASP A 324 CA CA A 501 1555 1555 2.27 LINK O GLY A 345 CA CA A 501 1555 1555 2.72 LINK O ASN A 347 CA CA A 501 1555 1555 2.25 LINK OD1 ASP A 379 CA CA A 502 1555 1555 2.23 LINK OD1 ASN A 381 CA CA A 502 1555 1555 2.31 LINK OD1 ASP A 387 CA CA A 502 1555 1555 2.45 LINK OD2 ASP A 387 CA CA A 502 1555 1555 2.25 LINK O ASN A 389 CA CA A 502 1555 1555 2.30 LINK O ASP B 293 CA CA B 501 1555 1555 2.25 LINK O GLY B 297 CA CA B 501 1555 1555 2.23 LINK OD2 ASP B 324 CA CA B 501 1555 1555 2.27 LINK O GLY B 345 CA CA B 501 1555 1555 2.72 LINK O ASN B 347 CA CA B 501 1555 1555 2.25 LINK OD1 ASP B 379 CA CA B 502 1555 1555 2.23 LINK OD1 ASN B 381 CA CA B 502 1555 1555 2.31 LINK OD1 ASP B 387 CA CA B 502 1555 1555 2.45 LINK OD2 ASP B 387 CA CA B 502 1555 1555 2.25 LINK O ASN B 389 CA CA B 502 1555 1555 2.30 LINK O ASP C 293 CA CA C 501 1555 1555 2.25 LINK O GLY C 297 CA CA C 501 1555 1555 2.23 LINK OD2 ASP C 324 CA CA C 501 1555 1555 2.27 LINK O GLY C 345 CA CA C 501 1555 1555 2.72 LINK O ASN C 347 CA CA C 501 1555 1555 2.25 LINK OD1 ASP C 379 CA CA C 502 1555 1555 2.23 LINK OD1 ASN C 381 CA CA C 502 1555 1555 2.31 LINK OD1 ASP C 387 CA CA C 502 1555 1555 2.45 LINK OD2 ASP C 387 CA CA C 502 1555 1555 2.25 LINK O ASN C 389 CA CA C 502 1555 1555 2.30 LINK O ASP D 293 CA CA D 501 1555 1555 2.25 LINK O GLY D 297 CA CA D 501 1555 1555 2.23 LINK OD2 ASP D 324 CA CA D 501 1555 1555 2.27 LINK O GLY D 345 CA CA D 501 1555 1555 2.72 LINK O ASN D 347 CA CA D 501 1555 1555 2.25 LINK OD1 ASP D 379 CA CA D 502 1555 1555 2.23 LINK OD1 ASN D 381 CA CA D 502 1555 1555 2.31 LINK OD1 ASP D 387 CA CA D 502 1555 1555 2.45 LINK OD2 ASP D 387 CA CA D 502 1555 1555 2.25 LINK O ASN D 389 CA CA D 502 1555 1555 2.30 CISPEP 1 SER I 7 PRO I 8 0 -4.90 CISPEP 2 TYR I 94 PRO I 95 0 -4.84 CISPEP 3 SER J 7 PRO J 8 0 -4.90 CISPEP 4 TYR J 94 PRO J 95 0 -4.84 CISPEP 5 SER K 7 PRO K 8 0 -4.90 CISPEP 6 TYR K 94 PRO K 95 0 -4.84 CISPEP 7 SER L 7 PRO L 8 0 -4.90 CISPEP 8 TYR L 94 PRO L 95 0 -4.84 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000