HEADER VIRAL PROTEIN/IMMUNE SYSTEM 16-APR-25 9O8R TITLE CRYO-EM STRUCTURE OF NI06063_D30_103 FAB IN COMPLEX WITH INFLUENZA TITLE 2 VIRUS HEMAGGLUTININ FROM A/MICHIGAN/45/2015 (H1N1) COMPND MOL_ID: 1; COMPND 2 MOLECULE: HEMAGGLUTININ; COMPND 3 CHAIN: A, C, D; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: HEMAGGLUTININ; COMPND 7 CHAIN: B, E, F; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: NI06063_D30_103 FAB HEAVY CHAIN; COMPND 11 CHAIN: H, G, I; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: NI06063_D30_103 FAB LIGHT CHAIN; COMPND 15 CHAIN: L, J, K; COMPND 16 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS (A/MICHIGAN/45/2015(H1N1)); SOURCE 3 ORGANISM_TAXID: 1777792; SOURCE 4 GENE: HA; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS (A/MICHIGAN/45/2015(H1N1)); SOURCE 9 ORGANISM_TAXID: 1777792; SOURCE 10 GENE: HA; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_TAXID: 9606; SOURCE 16 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 17 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 18 MOL_ID: 4; SOURCE 19 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 20 ORGANISM_TAXID: 9606; SOURCE 21 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 22 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS INFLUENZA, HEMAGGLUTININ, ANTIBODY COMPLEX, VIRAL PROTEIN, VIRAL KEYWDS 2 PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR G.JO,A.B.WARD REVDAT 1 04-FEB-26 9O8R 0 JRNL AUTH G.JO,A.B.WARD JRNL TITL A SINGLE AMINO ACID SUBSTITUTION IN HEMAGGLUTININ STALK JRNL TITL 2 DRIVES HETEROSUBTYPIC IMPRINTING OF CROSS-GROUP REACTIVE B JRNL TITL 3 CELLS IN CHILDREN JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.96 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, EPU, CRYOSPARC, PHENIX, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.960 REMARK 3 NUMBER OF PARTICLES : 276374 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9O8R COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 17-APR-25. REMARK 100 THE DEPOSITION ID IS D_1000294516. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF REMARK 245 NI06063_D30_103 FAB IN COMPLEX REMARK 245 WITH INFLUENZA VIRUS REMARK 245 HEMAGGLUTININ FROM A/MICHIGAN/ REMARK 245 45/2015 (H1N1) REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.80 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 4107 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1400.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4487.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, H, L, C, E, G, J, D, F, REMARK 350 AND CHAINS: I, K, M, N, O REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -6 REMARK 465 LYS A -5 REMARK 465 ALA A -4 REMARK 465 ILE A -3 REMARK 465 LEU A -2 REMARK 465 VAL A -1 REMARK 465 VAL A 0 REMARK 465 LEU A 1 REMARK 465 LEU A 2 REMARK 465 TYR A 3 REMARK 465 THR A 4 REMARK 465 PHE A 5 REMARK 465 THR A 6 REMARK 465 THR A 7 REMARK 465 ALA A 8 REMARK 465 ASN A 9 REMARK 465 ALA A 10 REMARK 465 ILE A 326 REMARK 465 GLN A 327 REMARK 465 SER A 328 REMARK 465 ARG A 329 REMARK 465 GLY B 1 REMARK 465 LEU B 2 REMARK 465 PHE B 3 REMARK 465 GLY B 4 REMARK 465 LYS B 172 REMARK 465 ILE B 173 REMARK 465 ASP B 174 REMARK 465 GLY B 175 REMARK 465 GLY B 176 REMARK 465 TYR B 177 REMARK 465 ILE B 178 REMARK 465 PRO B 179 REMARK 465 GLU B 180 REMARK 465 ALA B 181 REMARK 465 PRO B 182 REMARK 465 ARG B 183 REMARK 465 ASP B 184 REMARK 465 GLY B 185 REMARK 465 GLN B 186 REMARK 465 ALA B 187 REMARK 465 TYR B 188 REMARK 465 VAL B 189 REMARK 465 ARG B 190 REMARK 465 LYS B 191 REMARK 465 ASP B 192 REMARK 465 GLY B 193 REMARK 465 GLU B 194 REMARK 465 TRP B 195 REMARK 465 VAL B 196 REMARK 465 LEU B 197 REMARK 465 LEU B 198 REMARK 465 SER B 199 REMARK 465 THR B 200 REMARK 465 PHE B 201 REMARK 465 LEU B 202 REMARK 465 GLY B 203 REMARK 465 SER B 204 REMARK 465 GLU B 205 REMARK 465 ASN B 206 REMARK 465 LEU B 207 REMARK 465 TYR B 208 REMARK 465 PHE B 209 REMARK 465 GLN B 210 REMARK 465 GLY B 211 REMARK 465 SER B 212 REMARK 465 HIS B 213 REMARK 465 HIS B 214 REMARK 465 HIS B 215 REMARK 465 HIS B 216 REMARK 465 HIS B 217 REMARK 465 HIS B 218 REMARK 465 GLY B 219 REMARK 465 LEU B 220 REMARK 465 ASN B 221 REMARK 465 ASP B 222 REMARK 465 ILE B 223 REMARK 465 PHE B 224 REMARK 465 GLU B 225 REMARK 465 ALA B 226 REMARK 465 GLN B 227 REMARK 465 LYS B 228 REMARK 465 ILE B 229 REMARK 465 GLU B 230 REMARK 465 TRP B 231 REMARK 465 HIS B 232 REMARK 465 GLU B 233 REMARK 465 GLN L 1 REMARK 465 SER L 2 REMARK 465 MET C -6 REMARK 465 LYS C -5 REMARK 465 ALA C -4 REMARK 465 ILE C -3 REMARK 465 LEU C -2 REMARK 465 VAL C -1 REMARK 465 VAL C 0 REMARK 465 LEU C 1 REMARK 465 LEU C 2 REMARK 465 TYR C 3 REMARK 465 THR C 4 REMARK 465 PHE C 5 REMARK 465 THR C 6 REMARK 465 THR C 7 REMARK 465 ALA C 8 REMARK 465 ASN C 9 REMARK 465 ALA C 10 REMARK 465 ILE C 326 REMARK 465 GLN C 327 REMARK 465 SER C 328 REMARK 465 ARG C 329 REMARK 465 GLY E 1 REMARK 465 LEU E 2 REMARK 465 PHE E 3 REMARK 465 GLY E 4 REMARK 465 LYS E 172 REMARK 465 ILE E 173 REMARK 465 ASP E 174 REMARK 465 GLY E 175 REMARK 465 GLY E 176 REMARK 465 TYR E 177 REMARK 465 ILE E 178 REMARK 465 PRO E 179 REMARK 465 GLU E 180 REMARK 465 ALA E 181 REMARK 465 PRO E 182 REMARK 465 ARG E 183 REMARK 465 ASP E 184 REMARK 465 GLY E 185 REMARK 465 GLN E 186 REMARK 465 ALA E 187 REMARK 465 TYR E 188 REMARK 465 VAL E 189 REMARK 465 ARG E 190 REMARK 465 LYS E 191 REMARK 465 ASP E 192 REMARK 465 GLY E 193 REMARK 465 GLU E 194 REMARK 465 TRP E 195 REMARK 465 VAL E 196 REMARK 465 LEU E 197 REMARK 465 LEU E 198 REMARK 465 SER E 199 REMARK 465 THR E 200 REMARK 465 PHE E 201 REMARK 465 LEU E 202 REMARK 465 GLY E 203 REMARK 465 SER E 204 REMARK 465 GLU E 205 REMARK 465 ASN E 206 REMARK 465 LEU E 207 REMARK 465 TYR E 208 REMARK 465 PHE E 209 REMARK 465 GLN E 210 REMARK 465 GLY E 211 REMARK 465 SER E 212 REMARK 465 HIS E 213 REMARK 465 HIS E 214 REMARK 465 HIS E 215 REMARK 465 HIS E 216 REMARK 465 HIS E 217 REMARK 465 HIS E 218 REMARK 465 GLY E 219 REMARK 465 LEU E 220 REMARK 465 ASN E 221 REMARK 465 ASP E 222 REMARK 465 ILE E 223 REMARK 465 PHE E 224 REMARK 465 GLU E 225 REMARK 465 ALA E 226 REMARK 465 GLN E 227 REMARK 465 LYS E 228 REMARK 465 ILE E 229 REMARK 465 GLU E 230 REMARK 465 TRP E 231 REMARK 465 HIS E 232 REMARK 465 GLU E 233 REMARK 465 GLN J 1 REMARK 465 SER J 2 REMARK 465 MET D -6 REMARK 465 LYS D -5 REMARK 465 ALA D -4 REMARK 465 ILE D -3 REMARK 465 LEU D -2 REMARK 465 VAL D -1 REMARK 465 VAL D 0 REMARK 465 LEU D 1 REMARK 465 LEU D 2 REMARK 465 TYR D 3 REMARK 465 THR D 4 REMARK 465 PHE D 5 REMARK 465 THR D 6 REMARK 465 THR D 7 REMARK 465 ALA D 8 REMARK 465 ASN D 9 REMARK 465 ALA D 10 REMARK 465 ILE D 326 REMARK 465 GLN D 327 REMARK 465 SER D 328 REMARK 465 ARG D 329 REMARK 465 GLY F 1 REMARK 465 LEU F 2 REMARK 465 PHE F 3 REMARK 465 GLY F 4 REMARK 465 LYS F 172 REMARK 465 ILE F 173 REMARK 465 ASP F 174 REMARK 465 GLY F 175 REMARK 465 GLY F 176 REMARK 465 TYR F 177 REMARK 465 ILE F 178 REMARK 465 PRO F 179 REMARK 465 GLU F 180 REMARK 465 ALA F 181 REMARK 465 PRO F 182 REMARK 465 ARG F 183 REMARK 465 ASP F 184 REMARK 465 GLY F 185 REMARK 465 GLN F 186 REMARK 465 ALA F 187 REMARK 465 TYR F 188 REMARK 465 VAL F 189 REMARK 465 ARG F 190 REMARK 465 LYS F 191 REMARK 465 ASP F 192 REMARK 465 GLY F 193 REMARK 465 GLU F 194 REMARK 465 TRP F 195 REMARK 465 VAL F 196 REMARK 465 LEU F 197 REMARK 465 LEU F 198 REMARK 465 SER F 199 REMARK 465 THR F 200 REMARK 465 PHE F 201 REMARK 465 LEU F 202 REMARK 465 GLY F 203 REMARK 465 SER F 204 REMARK 465 GLU F 205 REMARK 465 ASN F 206 REMARK 465 LEU F 207 REMARK 465 TYR F 208 REMARK 465 PHE F 209 REMARK 465 GLN F 210 REMARK 465 GLY F 211 REMARK 465 SER F 212 REMARK 465 HIS F 213 REMARK 465 HIS F 214 REMARK 465 HIS F 215 REMARK 465 HIS F 216 REMARK 465 HIS F 217 REMARK 465 HIS F 218 REMARK 465 GLY F 219 REMARK 465 LEU F 220 REMARK 465 ASN F 221 REMARK 465 ASP F 222 REMARK 465 ILE F 223 REMARK 465 PHE F 224 REMARK 465 GLU F 225 REMARK 465 ALA F 226 REMARK 465 GLN F 227 REMARK 465 LYS F 228 REMARK 465 ILE F 229 REMARK 465 GLU F 230 REMARK 465 TRP F 231 REMARK 465 HIS F 232 REMARK 465 GLU F 233 REMARK 465 GLN K 1 REMARK 465 SER K 2 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 VAL H 100 CG1 CG2 REMARK 470 VAL G 100 CG1 CG2 REMARK 470 VAL I 100 CG1 CG2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 THR A 96 89.58 -65.64 REMARK 500 SER A 117 35.00 -141.22 REMARK 500 LYS A 163 109.87 -58.14 REMARK 500 VAL H 48 -62.85 -97.18 REMARK 500 LYS H 75 -6.90 74.64 REMARK 500 ALA L 8 -8.48 76.16 REMARK 500 SER L 9 139.88 -172.91 REMARK 500 VAL L 51 -60.61 72.79 REMARK 500 THR C 96 89.51 -65.57 REMARK 500 SER C 117 35.00 -141.26 REMARK 500 LYS C 163 109.90 -58.14 REMARK 500 VAL G 48 -62.80 -97.24 REMARK 500 LYS G 75 -6.91 74.61 REMARK 500 ALA J 8 -8.44 76.11 REMARK 500 SER J 9 139.93 -172.95 REMARK 500 VAL J 51 -60.68 72.85 REMARK 500 THR D 96 89.63 -65.65 REMARK 500 SER D 117 35.07 -141.26 REMARK 500 LYS D 163 109.90 -58.23 REMARK 500 VAL I 48 -62.90 -97.17 REMARK 500 LYS I 75 -6.93 74.60 REMARK 500 ALA K 8 -8.39 76.11 REMARK 500 SER K 9 139.94 -172.98 REMARK 500 VAL K 51 -60.69 72.87 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-70234 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF NI06063_D30_103 FAB IN COMPLEX WITH INFLUENZA REMARK 900 VIRUS HEMAGGLUTININ FROM A/MICHIGAN/45/2015 (H1N1) DBREF1 9O8R A -6 329 UNP A0A1J0CXU0_9INFA DBREF2 9O8R A A0A1J0CXU0 1 344 DBREF1 9O8R B 1 175 UNP A0A1J0CXU0_9INFA DBREF2 9O8R B A0A1J0CXU0 345 519 DBREF 9O8R H 1 113 PDB 9O8R 9O8R 1 113 DBREF 9O8R L 1 107 PDB 9O8R 9O8R 1 107 DBREF1 9O8R C -6 329 UNP A0A1J0CXU0_9INFA DBREF2 9O8R C A0A1J0CXU0 1 344 DBREF1 9O8R E 1 175 UNP A0A1J0CXU0_9INFA DBREF2 9O8R E A0A1J0CXU0 345 519 DBREF 9O8R G 1 113 PDB 9O8R 9O8R 1 113 DBREF 9O8R J 1 107 PDB 9O8R 9O8R 1 107 DBREF1 9O8R D -6 329 UNP A0A1J0CXU0_9INFA DBREF2 9O8R D A0A1J0CXU0 1 344 DBREF1 9O8R F 1 175 UNP A0A1J0CXU0_9INFA DBREF2 9O8R F A0A1J0CXU0 345 519 DBREF 9O8R I 1 113 PDB 9O8R 9O8R 1 113 DBREF 9O8R K 1 107 PDB 9O8R 9O8R 1 107 SEQADV 9O8R GLY B 176 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR B 177 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE B 178 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PRO B 179 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU B 180 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA B 181 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PRO B 182 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ARG B 183 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP B 184 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY B 185 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN B 186 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA B 187 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR B 188 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R VAL B 189 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ARG B 190 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LYS B 191 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP B 192 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY B 193 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU B 194 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TRP B 195 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R VAL B 196 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU B 197 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU B 198 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER B 199 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R THR B 200 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE B 201 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU B 202 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY B 203 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER B 204 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU B 205 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASN B 206 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU B 207 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR B 208 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE B 209 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN B 210 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY B 211 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER B 212 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS B 213 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS B 214 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS B 215 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS B 216 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS B 217 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS B 218 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY B 219 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU B 220 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASN B 221 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP B 222 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE B 223 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE B 224 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU B 225 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA B 226 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN B 227 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LYS B 228 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE B 229 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU B 230 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TRP B 231 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS B 232 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU B 233 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY E 176 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR E 177 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE E 178 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PRO E 179 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU E 180 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA E 181 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PRO E 182 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ARG E 183 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP E 184 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY E 185 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN E 186 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA E 187 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR E 188 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R VAL E 189 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ARG E 190 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LYS E 191 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP E 192 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY E 193 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU E 194 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TRP E 195 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R VAL E 196 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU E 197 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU E 198 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER E 199 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R THR E 200 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE E 201 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU E 202 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY E 203 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER E 204 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU E 205 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASN E 206 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU E 207 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR E 208 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE E 209 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN E 210 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY E 211 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER E 212 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS E 213 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS E 214 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS E 215 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS E 216 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS E 217 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS E 218 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY E 219 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU E 220 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASN E 221 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP E 222 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE E 223 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE E 224 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU E 225 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA E 226 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN E 227 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LYS E 228 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE E 229 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU E 230 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TRP E 231 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS E 232 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU E 233 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY F 176 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR F 177 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE F 178 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PRO F 179 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU F 180 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA F 181 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PRO F 182 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ARG F 183 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP F 184 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY F 185 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN F 186 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA F 187 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR F 188 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R VAL F 189 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ARG F 190 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LYS F 191 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP F 192 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY F 193 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU F 194 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TRP F 195 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R VAL F 196 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU F 197 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU F 198 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER F 199 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R THR F 200 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE F 201 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU F 202 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY F 203 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER F 204 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU F 205 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASN F 206 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU F 207 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TYR F 208 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE F 209 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN F 210 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY F 211 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R SER F 212 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS F 213 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS F 214 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS F 215 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS F 216 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS F 217 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS F 218 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLY F 219 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LEU F 220 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASN F 221 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ASP F 222 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE F 223 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R PHE F 224 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU F 225 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ALA F 226 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLN F 227 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R LYS F 228 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R ILE F 229 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU F 230 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R TRP F 231 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R HIS F 232 UNP A0A1J0CXU EXPRESSION TAG SEQADV 9O8R GLU F 233 UNP A0A1J0CXU EXPRESSION TAG SEQRES 1 A 344 MET LYS ALA ILE LEU VAL VAL LEU LEU TYR THR PHE THR SEQRES 2 A 344 THR ALA ASN ALA ASP THR LEU CYS ILE GLY TYR HIS ALA SEQRES 3 A 344 ASN ASN SER THR ASP THR VAL ASP THR VAL LEU GLU LYS SEQRES 4 A 344 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 A 344 LYS HIS ASN GLY LYS LEU CYS LYS LEU ARG GLY VAL ALA SEQRES 6 A 344 PRO LEU HIS LEU GLY LYS CYS ASN ILE ALA GLY TRP ILE SEQRES 7 A 344 LEU GLY ASN PRO GLU CYS GLU SER LEU SER THR ALA SER SEQRES 8 A 344 SER TRP SER TYR ILE VAL GLU THR SER ASN SER ASP ASN SEQRES 9 A 344 GLY THR CYS TYR PRO GLY ASP PHE ILE ASN TYR GLU GLU SEQRES 10 A 344 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 A 344 PHE GLU ILE PHE PRO LYS THR SER SER TRP PRO ASN HIS SEQRES 12 A 344 ASP SER ASN LYS GLY VAL THR ALA ALA CYS PRO HIS ALA SEQRES 13 A 344 GLY ALA LYS SER PHE TYR LYS ASN LEU ILE TRP LEU VAL SEQRES 14 A 344 LYS LYS GLY ASN SER TYR PRO LYS LEU ASN GLN SER TYR SEQRES 15 A 344 ILE ASN ASP LYS GLY LYS GLU VAL LEU VAL LEU TRP GLY SEQRES 16 A 344 ILE HIS HIS PRO SER THR THR ALA ASP GLN GLN SER LEU SEQRES 17 A 344 TYR GLN ASN ALA ASP ALA TYR VAL PHE VAL GLY THR SER SEQRES 18 A 344 ARG TYR SER LYS LYS PHE LYS PRO GLU ILE ALA THR ARG SEQRES 19 A 344 PRO LYS VAL ARG ASP GLN GLU GLY ARG MET ASN TYR TYR SEQRES 20 A 344 TRP THR LEU VAL GLU PRO GLY ASP LYS ILE THR PHE GLU SEQRES 21 A 344 ALA THR GLY ASN LEU VAL VAL PRO ARG TYR ALA PHE THR SEQRES 22 A 344 MET GLU ARG ASN ALA GLY SER GLY ILE ILE ILE SER ASP SEQRES 23 A 344 THR PRO VAL HIS ASP CYS ASN THR THR CYS GLN THR PRO SEQRES 24 A 344 GLU GLY ALA ILE ASN THR SER LEU PRO PHE GLN ASN ILE SEQRES 25 A 344 HIS PRO ILE THR ILE GLY LYS CYS PRO LYS TYR VAL LYS SEQRES 26 A 344 SER THR LYS LEU ARG LEU ALA THR GLY LEU ARG ASN VAL SEQRES 27 A 344 PRO SER ILE GLN SER ARG SEQRES 1 B 233 GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU GLY GLY SEQRES 2 B 233 TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR HIS HIS SEQRES 3 B 233 GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP LEU LYS SEQRES 4 B 233 SER THR GLN ASN ALA ILE ASP LYS ILE THR ASN LYS VAL SEQRES 5 B 233 ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE THR ALA SEQRES 6 B 233 VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG ILE GLU SEQRES 7 B 233 ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU ASP ILE SEQRES 8 B 233 TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU GLU ASN SEQRES 9 B 233 GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL LYS ASN SEQRES 10 B 233 LEU TYR GLU LYS VAL ARG ASN GLN LEU LYS ASN ASN ALA SEQRES 11 B 233 LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR HIS LYS SEQRES 12 B 233 CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN GLY THR SEQRES 13 B 233 TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS LEU ASN SEQRES 14 B 233 ARG GLU LYS ILE ASP GLY GLY TYR ILE PRO GLU ALA PRO SEQRES 15 B 233 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP SEQRES 16 B 233 VAL LEU LEU SER THR PHE LEU GLY SER GLU ASN LEU TYR SEQRES 17 B 233 PHE GLN GLY SER HIS HIS HIS HIS HIS HIS GLY LEU ASN SEQRES 18 B 233 ASP ILE PHE GLU ALA GLN LYS ILE GLU TRP HIS GLU SEQRES 1 H 121 GLN VAL HIS LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 H 121 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 H 121 PHE THR PHE SER ASN TYR GLY MET HIS TRP VAL ARG GLN SEQRES 4 H 121 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA PHE ILE SER SEQRES 5 H 121 TYR ASP GLY SER ASN GLU TYR TYR ALA ASP SER VAL LYS SEQRES 6 H 121 GLY ARG PHE THR ILE SER ARG ASP TYR SER LYS TYR THR SEQRES 7 H 121 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 H 121 ALA VAL TYR TYR CYS ALA LYS ASP GLY GLN TRP LEU VAL SEQRES 9 H 121 ARG GLY ALA PHE ASP PHE TRP GLY GLN GLY THR MET VAL SEQRES 10 H 121 THR VAL SER SER SEQRES 1 L 109 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 L 109 PRO GLY GLN SER ILE THR ILE SER CYS SER GLY THR GLY SEQRES 3 L 109 SER ASP VAL GLY SER SER HIS LEU VAL SER TRP TYR GLN SEQRES 4 L 109 HIS HIS PRO GLY LYS ALA PRO LYS LEU MET ILE PHE GLU SEQRES 5 L 109 VAL SER LYS ARG PRO LEU GLY VAL SER ASN ARG PHE SER SEQRES 6 L 109 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 L 109 GLY LEU GLN THR GLU ASP GLU ALA ASP TYR TYR CYS CYS SEQRES 8 L 109 SER TYR ALA GLY GLY ARG GLY VAL PHE GLY GLY GLY THR SEQRES 9 L 109 LYS LEU THR VAL LEU SEQRES 1 C 344 MET LYS ALA ILE LEU VAL VAL LEU LEU TYR THR PHE THR SEQRES 2 C 344 THR ALA ASN ALA ASP THR LEU CYS ILE GLY TYR HIS ALA SEQRES 3 C 344 ASN ASN SER THR ASP THR VAL ASP THR VAL LEU GLU LYS SEQRES 4 C 344 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 C 344 LYS HIS ASN GLY LYS LEU CYS LYS LEU ARG GLY VAL ALA SEQRES 6 C 344 PRO LEU HIS LEU GLY LYS CYS ASN ILE ALA GLY TRP ILE SEQRES 7 C 344 LEU GLY ASN PRO GLU CYS GLU SER LEU SER THR ALA SER SEQRES 8 C 344 SER TRP SER TYR ILE VAL GLU THR SER ASN SER ASP ASN SEQRES 9 C 344 GLY THR CYS TYR PRO GLY ASP PHE ILE ASN TYR GLU GLU SEQRES 10 C 344 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 C 344 PHE GLU ILE PHE PRO LYS THR SER SER TRP PRO ASN HIS SEQRES 12 C 344 ASP SER ASN LYS GLY VAL THR ALA ALA CYS PRO HIS ALA SEQRES 13 C 344 GLY ALA LYS SER PHE TYR LYS ASN LEU ILE TRP LEU VAL SEQRES 14 C 344 LYS LYS GLY ASN SER TYR PRO LYS LEU ASN GLN SER TYR SEQRES 15 C 344 ILE ASN ASP LYS GLY LYS GLU VAL LEU VAL LEU TRP GLY SEQRES 16 C 344 ILE HIS HIS PRO SER THR THR ALA ASP GLN GLN SER LEU SEQRES 17 C 344 TYR GLN ASN ALA ASP ALA TYR VAL PHE VAL GLY THR SER SEQRES 18 C 344 ARG TYR SER LYS LYS PHE LYS PRO GLU ILE ALA THR ARG SEQRES 19 C 344 PRO LYS VAL ARG ASP GLN GLU GLY ARG MET ASN TYR TYR SEQRES 20 C 344 TRP THR LEU VAL GLU PRO GLY ASP LYS ILE THR PHE GLU SEQRES 21 C 344 ALA THR GLY ASN LEU VAL VAL PRO ARG TYR ALA PHE THR SEQRES 22 C 344 MET GLU ARG ASN ALA GLY SER GLY ILE ILE ILE SER ASP SEQRES 23 C 344 THR PRO VAL HIS ASP CYS ASN THR THR CYS GLN THR PRO SEQRES 24 C 344 GLU GLY ALA ILE ASN THR SER LEU PRO PHE GLN ASN ILE SEQRES 25 C 344 HIS PRO ILE THR ILE GLY LYS CYS PRO LYS TYR VAL LYS SEQRES 26 C 344 SER THR LYS LEU ARG LEU ALA THR GLY LEU ARG ASN VAL SEQRES 27 C 344 PRO SER ILE GLN SER ARG SEQRES 1 E 233 GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU GLY GLY SEQRES 2 E 233 TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR HIS HIS SEQRES 3 E 233 GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP LEU LYS SEQRES 4 E 233 SER THR GLN ASN ALA ILE ASP LYS ILE THR ASN LYS VAL SEQRES 5 E 233 ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE THR ALA SEQRES 6 E 233 VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG ILE GLU SEQRES 7 E 233 ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU ASP ILE SEQRES 8 E 233 TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU GLU ASN SEQRES 9 E 233 GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL LYS ASN SEQRES 10 E 233 LEU TYR GLU LYS VAL ARG ASN GLN LEU LYS ASN ASN ALA SEQRES 11 E 233 LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR HIS LYS SEQRES 12 E 233 CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN GLY THR SEQRES 13 E 233 TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS LEU ASN SEQRES 14 E 233 ARG GLU LYS ILE ASP GLY GLY TYR ILE PRO GLU ALA PRO SEQRES 15 E 233 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP SEQRES 16 E 233 VAL LEU LEU SER THR PHE LEU GLY SER GLU ASN LEU TYR SEQRES 17 E 233 PHE GLN GLY SER HIS HIS HIS HIS HIS HIS GLY LEU ASN SEQRES 18 E 233 ASP ILE PHE GLU ALA GLN LYS ILE GLU TRP HIS GLU SEQRES 1 G 121 GLN VAL HIS LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 G 121 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 G 121 PHE THR PHE SER ASN TYR GLY MET HIS TRP VAL ARG GLN SEQRES 4 G 121 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA PHE ILE SER SEQRES 5 G 121 TYR ASP GLY SER ASN GLU TYR TYR ALA ASP SER VAL LYS SEQRES 6 G 121 GLY ARG PHE THR ILE SER ARG ASP TYR SER LYS TYR THR SEQRES 7 G 121 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 G 121 ALA VAL TYR TYR CYS ALA LYS ASP GLY GLN TRP LEU VAL SEQRES 9 G 121 ARG GLY ALA PHE ASP PHE TRP GLY GLN GLY THR MET VAL SEQRES 10 G 121 THR VAL SER SER SEQRES 1 J 109 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 J 109 PRO GLY GLN SER ILE THR ILE SER CYS SER GLY THR GLY SEQRES 3 J 109 SER ASP VAL GLY SER SER HIS LEU VAL SER TRP TYR GLN SEQRES 4 J 109 HIS HIS PRO GLY LYS ALA PRO LYS LEU MET ILE PHE GLU SEQRES 5 J 109 VAL SER LYS ARG PRO LEU GLY VAL SER ASN ARG PHE SER SEQRES 6 J 109 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 J 109 GLY LEU GLN THR GLU ASP GLU ALA ASP TYR TYR CYS CYS SEQRES 8 J 109 SER TYR ALA GLY GLY ARG GLY VAL PHE GLY GLY GLY THR SEQRES 9 J 109 LYS LEU THR VAL LEU SEQRES 1 D 344 MET LYS ALA ILE LEU VAL VAL LEU LEU TYR THR PHE THR SEQRES 2 D 344 THR ALA ASN ALA ASP THR LEU CYS ILE GLY TYR HIS ALA SEQRES 3 D 344 ASN ASN SER THR ASP THR VAL ASP THR VAL LEU GLU LYS SEQRES 4 D 344 ASN VAL THR VAL THR HIS SER VAL ASN LEU LEU GLU ASP SEQRES 5 D 344 LYS HIS ASN GLY LYS LEU CYS LYS LEU ARG GLY VAL ALA SEQRES 6 D 344 PRO LEU HIS LEU GLY LYS CYS ASN ILE ALA GLY TRP ILE SEQRES 7 D 344 LEU GLY ASN PRO GLU CYS GLU SER LEU SER THR ALA SER SEQRES 8 D 344 SER TRP SER TYR ILE VAL GLU THR SER ASN SER ASP ASN SEQRES 9 D 344 GLY THR CYS TYR PRO GLY ASP PHE ILE ASN TYR GLU GLU SEQRES 10 D 344 LEU ARG GLU GLN LEU SER SER VAL SER SER PHE GLU ARG SEQRES 11 D 344 PHE GLU ILE PHE PRO LYS THR SER SER TRP PRO ASN HIS SEQRES 12 D 344 ASP SER ASN LYS GLY VAL THR ALA ALA CYS PRO HIS ALA SEQRES 13 D 344 GLY ALA LYS SER PHE TYR LYS ASN LEU ILE TRP LEU VAL SEQRES 14 D 344 LYS LYS GLY ASN SER TYR PRO LYS LEU ASN GLN SER TYR SEQRES 15 D 344 ILE ASN ASP LYS GLY LYS GLU VAL LEU VAL LEU TRP GLY SEQRES 16 D 344 ILE HIS HIS PRO SER THR THR ALA ASP GLN GLN SER LEU SEQRES 17 D 344 TYR GLN ASN ALA ASP ALA TYR VAL PHE VAL GLY THR SER SEQRES 18 D 344 ARG TYR SER LYS LYS PHE LYS PRO GLU ILE ALA THR ARG SEQRES 19 D 344 PRO LYS VAL ARG ASP GLN GLU GLY ARG MET ASN TYR TYR SEQRES 20 D 344 TRP THR LEU VAL GLU PRO GLY ASP LYS ILE THR PHE GLU SEQRES 21 D 344 ALA THR GLY ASN LEU VAL VAL PRO ARG TYR ALA PHE THR SEQRES 22 D 344 MET GLU ARG ASN ALA GLY SER GLY ILE ILE ILE SER ASP SEQRES 23 D 344 THR PRO VAL HIS ASP CYS ASN THR THR CYS GLN THR PRO SEQRES 24 D 344 GLU GLY ALA ILE ASN THR SER LEU PRO PHE GLN ASN ILE SEQRES 25 D 344 HIS PRO ILE THR ILE GLY LYS CYS PRO LYS TYR VAL LYS SEQRES 26 D 344 SER THR LYS LEU ARG LEU ALA THR GLY LEU ARG ASN VAL SEQRES 27 D 344 PRO SER ILE GLN SER ARG SEQRES 1 F 233 GLY LEU PHE GLY ALA ILE ALA GLY PHE ILE GLU GLY GLY SEQRES 2 F 233 TRP THR GLY MET VAL ASP GLY TRP TYR GLY TYR HIS HIS SEQRES 3 F 233 GLN ASN GLU GLN GLY SER GLY TYR ALA ALA ASP LEU LYS SEQRES 4 F 233 SER THR GLN ASN ALA ILE ASP LYS ILE THR ASN LYS VAL SEQRES 5 F 233 ASN SER VAL ILE GLU LYS MET ASN THR GLN PHE THR ALA SEQRES 6 F 233 VAL GLY LYS GLU PHE ASN HIS LEU GLU LYS ARG ILE GLU SEQRES 7 F 233 ASN LEU ASN LYS LYS VAL ASP ASP GLY PHE LEU ASP ILE SEQRES 8 F 233 TRP THR TYR ASN ALA GLU LEU LEU VAL LEU LEU GLU ASN SEQRES 9 F 233 GLU ARG THR LEU ASP TYR HIS ASP SER ASN VAL LYS ASN SEQRES 10 F 233 LEU TYR GLU LYS VAL ARG ASN GLN LEU LYS ASN ASN ALA SEQRES 11 F 233 LYS GLU ILE GLY ASN GLY CYS PHE GLU PHE TYR HIS LYS SEQRES 12 F 233 CYS ASP ASN THR CYS MET GLU SER VAL LYS ASN GLY THR SEQRES 13 F 233 TYR ASP TYR PRO LYS TYR SER GLU GLU ALA LYS LEU ASN SEQRES 14 F 233 ARG GLU LYS ILE ASP GLY GLY TYR ILE PRO GLU ALA PRO SEQRES 15 F 233 ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU TRP SEQRES 16 F 233 VAL LEU LEU SER THR PHE LEU GLY SER GLU ASN LEU TYR SEQRES 17 F 233 PHE GLN GLY SER HIS HIS HIS HIS HIS HIS GLY LEU ASN SEQRES 18 F 233 ASP ILE PHE GLU ALA GLN LYS ILE GLU TRP HIS GLU SEQRES 1 I 121 GLN VAL HIS LEU VAL GLU SER GLY GLY GLY VAL VAL GLN SEQRES 2 I 121 PRO GLY ARG SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 I 121 PHE THR PHE SER ASN TYR GLY MET HIS TRP VAL ARG GLN SEQRES 4 I 121 ALA PRO GLY LYS GLY LEU GLU TRP VAL ALA PHE ILE SER SEQRES 5 I 121 TYR ASP GLY SER ASN GLU TYR TYR ALA ASP SER VAL LYS SEQRES 6 I 121 GLY ARG PHE THR ILE SER ARG ASP TYR SER LYS TYR THR SEQRES 7 I 121 LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR SEQRES 8 I 121 ALA VAL TYR TYR CYS ALA LYS ASP GLY GLN TRP LEU VAL SEQRES 9 I 121 ARG GLY ALA PHE ASP PHE TRP GLY GLN GLY THR MET VAL SEQRES 10 I 121 THR VAL SER SER SEQRES 1 K 109 GLN SER ALA LEU THR GLN PRO ALA SER VAL SER GLY SER SEQRES 2 K 109 PRO GLY GLN SER ILE THR ILE SER CYS SER GLY THR GLY SEQRES 3 K 109 SER ASP VAL GLY SER SER HIS LEU VAL SER TRP TYR GLN SEQRES 4 K 109 HIS HIS PRO GLY LYS ALA PRO LYS LEU MET ILE PHE GLU SEQRES 5 K 109 VAL SER LYS ARG PRO LEU GLY VAL SER ASN ARG PHE SER SEQRES 6 K 109 GLY SER LYS SER GLY ASN THR ALA SER LEU THR ILE SER SEQRES 7 K 109 GLY LEU GLN THR GLU ASP GLU ALA ASP TYR TYR CYS CYS SEQRES 8 K 109 SER TYR ALA GLY GLY ARG GLY VAL PHE GLY GLY GLY THR SEQRES 9 K 109 LYS LEU THR VAL LEU HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HET NAG A 401 14 HET NAG A 402 14 HET NAG A 403 14 HET NAG A 404 14 HET NAG B 301 14 HET NAG C 401 14 HET NAG C 402 14 HET NAG C 403 14 HET NAG C 404 14 HET NAG E 301 14 HET NAG D 401 14 HET NAG D 402 14 HET NAG D 403 14 HET NAG D 404 14 HET NAG F 301 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 13 NAG 21(C8 H15 N O6) HELIX 1 AA1 ASN A 65 GLY A 72 1 8 HELIX 2 AA2 ASN A 73 GLU A 77 5 5 HELIX 3 AA3 ASN A 104 LEU A 112 1 9 HELIX 4 AA4 PRO A 125 TRP A 127 1 6 HELIX 5 AA5 THR A 187 TYR A 195 1 9 HELIX 6 AA6 ASP B 37 LYS B 58 1 22 HELIX 7 AA7 GLU B 74 LEU B 126 1 53 HELIX 8 AA8 ASP B 145 ASN B 154 1 10 HELIX 9 AA9 ASP B 158 GLU B 171 1 14 HELIX 10 AB1 THR H 28 TYR H 32 5 5 HELIX 11 AB2 ARG H 83 THR H 87 5 5 HELIX 12 AB3 ASN C 65 GLY C 72 1 8 HELIX 13 AB4 ASN C 73 GLU C 77 5 5 HELIX 14 AB5 ASN C 104 LEU C 112 1 9 HELIX 15 AB6 PRO C 125 TRP C 127 1 6 HELIX 16 AB7 THR C 187 TYR C 195 1 9 HELIX 17 AB8 ASP E 37 LYS E 58 1 22 HELIX 18 AB9 GLU E 74 LEU E 126 1 53 HELIX 19 AC1 ASP E 145 ASN E 154 1 10 HELIX 20 AC2 ASP E 158 GLU E 171 1 14 HELIX 21 AC3 THR G 28 TYR G 32 5 5 HELIX 22 AC4 ARG G 83 THR G 87 5 5 HELIX 23 AC5 ASN D 65 GLY D 72 1 8 HELIX 24 AC6 ASN D 73 GLU D 77 5 5 HELIX 25 AC7 ASN D 104 LEU D 112 1 9 HELIX 26 AC8 PRO D 125 TRP D 127 1 6 HELIX 27 AC9 THR D 187 TYR D 195 1 9 HELIX 28 AD1 ASP F 37 LYS F 58 1 22 HELIX 29 AD2 GLU F 74 LEU F 126 1 53 HELIX 30 AD3 ASP F 145 ASN F 154 1 10 HELIX 31 AD4 ASP F 158 GLU F 171 1 14 HELIX 32 AD5 THR I 28 TYR I 32 5 5 HELIX 33 AD6 ARG I 83 THR I 87 5 5 SHEET 1 AA1 5 GLY B 31 ALA B 36 0 SHEET 2 AA1 5 TYR B 22 ASN B 28 -1 N TYR B 24 O ALA B 35 SHEET 3 AA1 5 THR A 12 TYR A 17 -1 N CYS A 14 O HIS B 25 SHEET 4 AA1 5 CYS B 137 PHE B 140 -1 O PHE B 138 N LEU A 13 SHEET 5 AA1 5 ALA B 130 GLU B 132 -1 N LYS B 131 O GLU B 139 SHEET 1 AA2 2 THR A 25 VAL A 26 0 SHEET 2 AA2 2 VAL A 34 THR A 35 -1 O VAL A 34 N VAL A 26 SHEET 1 AA3 2 SER A 39 ASN A 41 0 SHEET 2 AA3 2 ARG A 315 ALA A 317 -1 O LEU A 316 N VAL A 40 SHEET 1 AA4 3 LEU A 43 GLU A 44 0 SHEET 2 AA4 3 PHE A 294 GLN A 295 1 O PHE A 294 N GLU A 44 SHEET 3 AA4 3 LYS A 307 TYR A 308 1 O LYS A 307 N GLN A 295 SHEET 1 AA5 2 LEU A 51 LEU A 54 0 SHEET 2 AA5 2 VAL A 274 THR A 279 1 O CYS A 277 N LYS A 53 SHEET 1 AA6 3 LEU A 59 HIS A 60 0 SHEET 2 AA6 3 ILE A 87 GLU A 89 1 O VAL A 88 N LEU A 59 SHEET 3 AA6 3 ILE A 267 ILE A 269 1 O ILE A 268 N ILE A 87 SHEET 1 AA7 5 GLU A 119 PHE A 121 0 SHEET 2 AA7 5 ALA A 257 MET A 260 -1 O ALA A 257 N PHE A 121 SHEET 3 AA7 5 GLU A 175 HIS A 184 -1 N GLU A 175 O MET A 260 SHEET 4 AA7 5 LEU A 251 PRO A 254 -1 O VAL A 252 N GLY A 181 SHEET 5 AA7 5 LEU A 151 TRP A 153 -1 N ILE A 152 O VAL A 253 SHEET 1 AA8 4 GLU A 119 PHE A 121 0 SHEET 2 AA8 4 ALA A 257 MET A 260 -1 O ALA A 257 N PHE A 121 SHEET 3 AA8 4 GLU A 175 HIS A 184 -1 N GLU A 175 O MET A 260 SHEET 4 AA8 4 ARG A 229 VAL A 237 -1 O ARG A 229 N HIS A 184 SHEET 1 AA9 2 THR A 136 HIS A 141 0 SHEET 2 AA9 2 ALA A 144 SER A 146 -1 O ALA A 144 N HIS A 141 SHEET 1 AB1 4 LEU A 164 ILE A 169 0 SHEET 2 AB1 4 LYS A 242 ALA A 247 -1 O PHE A 245 N GLN A 166 SHEET 3 AB1 4 VAL A 202 THR A 206 -1 N PHE A 203 O GLU A 246 SHEET 4 AB1 4 TYR A 209 PHE A 213 -1 O PHE A 213 N VAL A 202 SHEET 1 AB2 3 CYS A 281 GLN A 282 0 SHEET 2 AB2 3 ILE A 302 GLY A 303 -1 O ILE A 302 N GLN A 282 SHEET 3 AB2 3 THR B 64 ALA B 65 -1 O THR B 64 N GLY A 303 SHEET 1 AB3 4 HIS H 3 SER H 7 0 SHEET 2 AB3 4 LEU H 18 SER H 25 -1 O SER H 21 N SER H 7 SHEET 3 AB3 4 THR H 77 MET H 82 -1 O LEU H 78 N CYS H 22 SHEET 4 AB3 4 PHE H 67 ASP H 72 -1 N SER H 70 O TYR H 79 SHEET 1 AB4 6 GLY H 10 VAL H 12 0 SHEET 2 AB4 6 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB4 6 ALA H 88 ASP H 95 -1 N TYR H 90 O THR H 107 SHEET 4 AB4 6 MET H 34 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AB4 6 LEU H 45 ILE H 51 -1 O ILE H 51 N MET H 34 SHEET 6 AB4 6 GLU H 57 TYR H 59 -1 O TYR H 58 N PHE H 50 SHEET 1 AB5 4 GLY H 10 VAL H 12 0 SHEET 2 AB5 4 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AB5 4 ALA H 88 ASP H 95 -1 N TYR H 90 O THR H 107 SHEET 4 AB5 4 PHE H 100D TRP H 103 -1 O PHE H 102 N LYS H 94 SHEET 1 AB6 2 SER L 9 GLY L 13 0 SHEET 2 AB6 2 LYS L 103 VAL L 106 1 O THR L 105 N GLY L 13 SHEET 1 AB7 3 SER L 18 SER L 24 0 SHEET 2 AB7 3 THR L 70 SER L 76 -1 O ALA L 71 N CYS L 23 SHEET 3 AB7 3 PHE L 62 SER L 67 -1 N SER L 67 O THR L 70 SHEET 1 AB8 4 LYS L 45 ILE L 48 0 SHEET 2 AB8 4 SER L 34 HIS L 38 -1 N GLN L 37 O LYS L 45 SHEET 3 AB8 4 ASP L 85 ALA L 92 -1 O CYS L 89 N SER L 34 SHEET 4 AB8 4 ARG L 95 PHE L 98 -1 O VAL L 97 N SER L 90 SHEET 1 AB9 5 GLY E 31 ALA E 36 0 SHEET 2 AB9 5 TYR E 22 ASN E 28 -1 N TYR E 24 O ALA E 35 SHEET 3 AB9 5 THR C 12 TYR C 17 -1 N CYS C 14 O HIS E 25 SHEET 4 AB9 5 CYS E 137 PHE E 140 -1 O PHE E 138 N LEU C 13 SHEET 5 AB9 5 ALA E 130 GLU E 132 -1 N LYS E 131 O GLU E 139 SHEET 1 AC1 2 THR C 25 VAL C 26 0 SHEET 2 AC1 2 VAL C 34 THR C 35 -1 O VAL C 34 N VAL C 26 SHEET 1 AC2 2 SER C 39 ASN C 41 0 SHEET 2 AC2 2 ARG C 315 ALA C 317 -1 O LEU C 316 N VAL C 40 SHEET 1 AC3 3 LEU C 43 GLU C 44 0 SHEET 2 AC3 3 PHE C 294 GLN C 295 1 O PHE C 294 N GLU C 44 SHEET 3 AC3 3 LYS C 307 TYR C 308 1 O LYS C 307 N GLN C 295 SHEET 1 AC4 2 LEU C 51 LEU C 54 0 SHEET 2 AC4 2 VAL C 274 THR C 279 1 O CYS C 277 N LYS C 53 SHEET 1 AC5 3 LEU C 59 HIS C 60 0 SHEET 2 AC5 3 ILE C 87 GLU C 89 1 O VAL C 88 N LEU C 59 SHEET 3 AC5 3 ILE C 267 ILE C 269 1 O ILE C 268 N ILE C 87 SHEET 1 AC6 5 GLU C 119 PHE C 121 0 SHEET 2 AC6 5 ALA C 257 MET C 260 -1 O ALA C 257 N PHE C 121 SHEET 3 AC6 5 GLU C 175 HIS C 184 -1 N GLU C 175 O MET C 260 SHEET 4 AC6 5 LEU C 251 PRO C 254 -1 O VAL C 252 N GLY C 181 SHEET 5 AC6 5 LEU C 151 TRP C 153 -1 N ILE C 152 O VAL C 253 SHEET 1 AC7 4 GLU C 119 PHE C 121 0 SHEET 2 AC7 4 ALA C 257 MET C 260 -1 O ALA C 257 N PHE C 121 SHEET 3 AC7 4 GLU C 175 HIS C 184 -1 N GLU C 175 O MET C 260 SHEET 4 AC7 4 ARG C 229 VAL C 237 -1 O ARG C 229 N HIS C 184 SHEET 1 AC8 2 THR C 136 HIS C 141 0 SHEET 2 AC8 2 ALA C 144 SER C 146 -1 O ALA C 144 N HIS C 141 SHEET 1 AC9 4 LEU C 164 ILE C 169 0 SHEET 2 AC9 4 LYS C 242 ALA C 247 -1 O PHE C 245 N GLN C 166 SHEET 3 AC9 4 VAL C 202 THR C 206 -1 N PHE C 203 O GLU C 246 SHEET 4 AC9 4 TYR C 209 PHE C 213 -1 O PHE C 213 N VAL C 202 SHEET 1 AD1 3 CYS C 281 GLN C 282 0 SHEET 2 AD1 3 ILE C 302 GLY C 303 -1 O ILE C 302 N GLN C 282 SHEET 3 AD1 3 THR E 64 ALA E 65 -1 O THR E 64 N GLY C 303 SHEET 1 AD2 4 HIS G 3 SER G 7 0 SHEET 2 AD2 4 LEU G 18 SER G 25 -1 O SER G 21 N SER G 7 SHEET 3 AD2 4 THR G 77 MET G 82 -1 O LEU G 78 N CYS G 22 SHEET 4 AD2 4 PHE G 67 ASP G 72 -1 N SER G 70 O TYR G 79 SHEET 1 AD3 6 GLY G 10 VAL G 12 0 SHEET 2 AD3 6 THR G 107 VAL G 111 1 O THR G 110 N VAL G 12 SHEET 3 AD3 6 ALA G 88 ASP G 95 -1 N TYR G 90 O THR G 107 SHEET 4 AD3 6 MET G 34 GLN G 39 -1 N VAL G 37 O TYR G 91 SHEET 5 AD3 6 LEU G 45 ILE G 51 -1 O ILE G 51 N MET G 34 SHEET 6 AD3 6 GLU G 57 TYR G 59 -1 O TYR G 58 N PHE G 50 SHEET 1 AD4 4 GLY G 10 VAL G 12 0 SHEET 2 AD4 4 THR G 107 VAL G 111 1 O THR G 110 N VAL G 12 SHEET 3 AD4 4 ALA G 88 ASP G 95 -1 N TYR G 90 O THR G 107 SHEET 4 AD4 4 PHE G 100D TRP G 103 -1 O PHE G 102 N LYS G 94 SHEET 1 AD5 2 SER J 9 GLY J 13 0 SHEET 2 AD5 2 LYS J 103 VAL J 106 1 O THR J 105 N GLY J 13 SHEET 1 AD6 3 SER J 18 SER J 24 0 SHEET 2 AD6 3 THR J 70 SER J 76 -1 O ALA J 71 N CYS J 23 SHEET 3 AD6 3 PHE J 62 SER J 67 -1 N SER J 67 O THR J 70 SHEET 1 AD7 4 LYS J 45 ILE J 48 0 SHEET 2 AD7 4 SER J 34 HIS J 38 -1 N GLN J 37 O LYS J 45 SHEET 3 AD7 4 ASP J 85 ALA J 92 -1 O CYS J 89 N SER J 34 SHEET 4 AD7 4 ARG J 95 PHE J 98 -1 O VAL J 97 N SER J 90 SHEET 1 AD8 5 GLY F 31 ALA F 36 0 SHEET 2 AD8 5 TYR F 22 ASN F 28 -1 N TYR F 24 O ALA F 35 SHEET 3 AD8 5 THR D 12 TYR D 17 -1 N CYS D 14 O HIS F 25 SHEET 4 AD8 5 CYS F 137 PHE F 140 -1 O PHE F 138 N LEU D 13 SHEET 5 AD8 5 ALA F 130 GLU F 132 -1 N LYS F 131 O GLU F 139 SHEET 1 AD9 2 THR D 25 VAL D 26 0 SHEET 2 AD9 2 VAL D 34 THR D 35 -1 O VAL D 34 N VAL D 26 SHEET 1 AE1 2 SER D 39 ASN D 41 0 SHEET 2 AE1 2 ARG D 315 ALA D 317 -1 O LEU D 316 N VAL D 40 SHEET 1 AE2 3 LEU D 43 GLU D 44 0 SHEET 2 AE2 3 PHE D 294 GLN D 295 1 O PHE D 294 N GLU D 44 SHEET 3 AE2 3 LYS D 307 TYR D 308 1 O LYS D 307 N GLN D 295 SHEET 1 AE3 2 LEU D 51 LEU D 54 0 SHEET 2 AE3 2 VAL D 274 THR D 279 1 O CYS D 277 N LYS D 53 SHEET 1 AE4 3 LEU D 59 HIS D 60 0 SHEET 2 AE4 3 ILE D 87 GLU D 89 1 O VAL D 88 N LEU D 59 SHEET 3 AE4 3 ILE D 267 ILE D 269 1 O ILE D 268 N ILE D 87 SHEET 1 AE5 5 GLU D 119 PHE D 121 0 SHEET 2 AE5 5 ALA D 257 MET D 260 -1 O ALA D 257 N PHE D 121 SHEET 3 AE5 5 GLU D 175 HIS D 184 -1 N GLU D 175 O MET D 260 SHEET 4 AE5 5 LEU D 251 PRO D 254 -1 O VAL D 252 N GLY D 181 SHEET 5 AE5 5 LEU D 151 TRP D 153 -1 N ILE D 152 O VAL D 253 SHEET 1 AE6 4 GLU D 119 PHE D 121 0 SHEET 2 AE6 4 ALA D 257 MET D 260 -1 O ALA D 257 N PHE D 121 SHEET 3 AE6 4 GLU D 175 HIS D 184 -1 N GLU D 175 O MET D 260 SHEET 4 AE6 4 ARG D 229 VAL D 237 -1 O ARG D 229 N HIS D 184 SHEET 1 AE7 2 THR D 136 HIS D 141 0 SHEET 2 AE7 2 ALA D 144 SER D 146 -1 O ALA D 144 N HIS D 141 SHEET 1 AE8 4 LEU D 164 ILE D 169 0 SHEET 2 AE8 4 LYS D 242 ALA D 247 -1 O PHE D 245 N GLN D 166 SHEET 3 AE8 4 VAL D 202 THR D 206 -1 N PHE D 203 O GLU D 246 SHEET 4 AE8 4 TYR D 209 PHE D 213 -1 O PHE D 213 N VAL D 202 SHEET 1 AE9 3 CYS D 281 GLN D 282 0 SHEET 2 AE9 3 ILE D 302 GLY D 303 -1 O ILE D 302 N GLN D 282 SHEET 3 AE9 3 THR F 64 ALA F 65 -1 O THR F 64 N GLY D 303 SHEET 1 AF1 4 HIS I 3 SER I 7 0 SHEET 2 AF1 4 LEU I 18 SER I 25 -1 O SER I 21 N SER I 7 SHEET 3 AF1 4 THR I 77 MET I 82 -1 O LEU I 78 N CYS I 22 SHEET 4 AF1 4 PHE I 67 ASP I 72 -1 N SER I 70 O TYR I 79 SHEET 1 AF2 6 GLY I 10 VAL I 12 0 SHEET 2 AF2 6 THR I 107 VAL I 111 1 O THR I 110 N VAL I 12 SHEET 3 AF2 6 ALA I 88 ASP I 95 -1 N TYR I 90 O THR I 107 SHEET 4 AF2 6 MET I 34 GLN I 39 -1 N VAL I 37 O TYR I 91 SHEET 5 AF2 6 LEU I 45 ILE I 51 -1 O ILE I 51 N MET I 34 SHEET 6 AF2 6 GLU I 57 TYR I 59 -1 O TYR I 58 N PHE I 50 SHEET 1 AF3 4 GLY I 10 VAL I 12 0 SHEET 2 AF3 4 THR I 107 VAL I 111 1 O THR I 110 N VAL I 12 SHEET 3 AF3 4 ALA I 88 ASP I 95 -1 N TYR I 90 O THR I 107 SHEET 4 AF3 4 PHE I 100D TRP I 103 -1 O PHE I 102 N LYS I 94 SHEET 1 AF4 2 SER K 9 GLY K 13 0 SHEET 2 AF4 2 LYS K 103 VAL K 106 1 O THR K 105 N GLY K 13 SHEET 1 AF5 3 SER K 18 SER K 24 0 SHEET 2 AF5 3 THR K 70 SER K 76 -1 O ALA K 71 N CYS K 23 SHEET 3 AF5 3 PHE K 62 SER K 67 -1 N SER K 67 O THR K 70 SHEET 1 AF6 4 LYS K 45 ILE K 48 0 SHEET 2 AF6 4 SER K 34 HIS K 38 -1 N GLN K 37 O LYS K 45 SHEET 3 AF6 4 ASP K 85 ALA K 92 -1 O CYS K 89 N SER K 34 SHEET 4 AF6 4 ARG K 95 PHE K 98 -1 O VAL K 97 N SER K 90 SSBOND 1 CYS A 14 CYS B 137 1555 1555 2.03 SSBOND 2 CYS A 52 CYS A 277 1555 1555 2.04 SSBOND 3 CYS A 64 CYS A 76 1555 1555 2.02 SSBOND 4 CYS A 97 CYS A 139 1555 1555 2.03 SSBOND 5 CYS A 281 CYS A 305 1555 1555 2.03 SSBOND 6 CYS B 144 CYS B 148 1555 1555 2.03 SSBOND 7 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 8 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 9 CYS C 14 CYS E 137 1555 1555 2.03 SSBOND 10 CYS C 52 CYS C 277 1555 1555 2.04 SSBOND 11 CYS C 64 CYS C 76 1555 1555 2.02 SSBOND 12 CYS C 97 CYS C 139 1555 1555 2.03 SSBOND 13 CYS C 281 CYS C 305 1555 1555 2.03 SSBOND 14 CYS E 144 CYS E 148 1555 1555 2.03 SSBOND 15 CYS G 22 CYS G 92 1555 1555 2.03 SSBOND 16 CYS J 23 CYS J 88 1555 1555 2.03 SSBOND 17 CYS D 14 CYS F 137 1555 1555 2.03 SSBOND 18 CYS D 52 CYS D 277 1555 1555 2.04 SSBOND 19 CYS D 64 CYS D 76 1555 1555 2.02 SSBOND 20 CYS D 97 CYS D 139 1555 1555 2.03 SSBOND 21 CYS D 281 CYS D 305 1555 1555 2.03 SSBOND 22 CYS F 144 CYS F 148 1555 1555 2.03 SSBOND 23 CYS I 22 CYS I 92 1555 1555 2.03 SSBOND 24 CYS K 23 CYS K 88 1555 1555 2.03 LINK ND2 ASN A 21 C1 NAG A 401 1555 1555 1.44 LINK ND2 ASN A 33 C1 NAG A 402 1555 1555 1.44 LINK ND2 ASN A 94 C1 NAG M 1 1555 1555 1.43 LINK ND2 ASN A 278 C1 NAG A 403 1555 1555 1.44 LINK ND2 ASN A 289 C1 NAG A 404 1555 1555 1.44 LINK ND2 ASN B 154 C1 NAG B 301 1555 1555 1.44 LINK ND2 ASN C 21 C1 NAG C 401 1555 1555 1.44 LINK ND2 ASN C 33 C1 NAG C 402 1555 1555 1.44 LINK ND2 ASN C 94 C1 NAG N 1 1555 1555 1.43 LINK ND2 ASN C 278 C1 NAG C 403 1555 1555 1.44 LINK ND2 ASN C 289 C1 NAG C 404 1555 1555 1.44 LINK ND2 ASN E 154 C1 NAG E 301 1555 1555 1.44 LINK ND2 ASN D 21 C1 NAG D 401 1555 1555 1.44 LINK ND2 ASN D 33 C1 NAG D 402 1555 1555 1.44 LINK ND2 ASN D 94 C1 NAG O 1 1555 1555 1.43 LINK ND2 ASN D 278 C1 NAG D 403 1555 1555 1.44 LINK ND2 ASN D 289 C1 NAG D 404 1555 1555 1.44 LINK ND2 ASN F 154 C1 NAG F 301 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000