HEADER VIRAL PROTEIN 18-APR-25 9O9V TITLE NCS.1.1 FAB IN COMPLEX WITH THE SNAP OF A/CALIFORNIA/04/2009 (CA09, TITLE 2 H1N1) -- 4 FABS [C1 RECONSTRUCTION] COMPND MOL_ID: 1; COMPND 2 MOLECULE: NEURAMINIDASE; COMPND 3 CHAIN: D, E, F, K; COMPND 4 EC: 3.2.1.18; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: NCS.1.1 HEAVY CHAIN; COMPND 8 CHAIN: H, I, J, O; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: NCS.1.1 LIGHT CHAIN; COMPND 12 CHAIN: L, M, N, P; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: INFLUENZA A VIRUS; SOURCE 3 ORGANISM_TAXID: 11320; SOURCE 4 GENE: NA; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 10 ORGANISM_COMMON: HUMAN; SOURCE 11 ORGANISM_TAXID: 9606; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_COMMON: HUMAN; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS NEURAMINIDASE, NCS.1.1, TETRAMER, ANTIBODY, FAB, N1, H1N5, CA09, KEYWDS 2 VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR A.J.BORST REVDAT 1 13-AUG-25 9O9V 0 JRNL AUTH J.LEDERHOFER,A.J.BORST,L.NGUYEN,R.A.GILLESPIE,C.J.WILLIAMS, JRNL AUTH 2 E.L.WALKER,J.E.RAAB,C.YAP,D.ELLIS,A.CREANGA,H.X.TAN, JRNL AUTH 3 T.H.T.DO,M.RAVICHANDRAN,A.B.MCDERMOTT,V.LE SAGE,S.F.ANDREWS, JRNL AUTH 4 B.S.GRAHAM,A.K.WHEATLEY,D.S.REED,N.P.KING,M.KANEKIYO JRNL TITL STRUCTURAL CONVERGENCE AND WATER-MEDIATED SUBSTRATE MIMICRY JRNL TITL 2 ENABLE BROAD NEURAMINIDASE INHIBITION BY HUMAN ANTIBODIES. JRNL REF NAT COMMUN V. 16 7068 2025 JRNL REFN ESSN 2041-1723 JRNL PMID 40750617 JRNL DOI 10.1038/S41467-025-62339-Z REMARK 2 REMARK 2 RESOLUTION. 2.50 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : COOT, UCSF CHIMERAX, ISOLDE, ISOLDE, REMARK 3 PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.500 REMARK 3 NUMBER OF PARTICLES : 382836 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9O9V COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-APR-25. REMARK 100 THE DEPOSITION ID IS D_1000295167. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : NCS.1.1 FAB IN COMPLEX WITH THE REMARK 245 SNAP OF A/CALIFORNIA/04/2009 REMARK 245 (CA09, H1N1) -- 4 FABS REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, E, F, H, I, J, K, L, M, N, REMARK 350 AND CHAINS: O, P, A, B, C, G REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 HIS D 26 REMARK 465 HIS D 27 REMARK 465 HIS D 28 REMARK 465 HIS D 29 REMARK 465 HIS D 30 REMARK 465 HIS D 31 REMARK 465 SER D 32 REMARK 465 SER D 33 REMARK 465 SER D 34 REMARK 465 ASP D 35 REMARK 465 TYR D 36 REMARK 465 SER D 37 REMARK 465 ASP D 38 REMARK 465 LEU D 39 REMARK 465 GLN D 40 REMARK 465 ARG D 41 REMARK 465 VAL D 42 REMARK 465 LYS D 43 REMARK 465 GLN D 44 REMARK 465 GLU D 45 REMARK 465 LEU D 46 REMARK 465 LEU D 47 REMARK 465 GLU D 48 REMARK 465 GLU D 49 REMARK 465 VAL D 50 REMARK 465 LYS D 51 REMARK 465 LYS D 52 REMARK 465 GLU D 53 REMARK 465 LEU D 54 REMARK 465 GLN D 55 REMARK 465 LYS D 56 REMARK 465 VAL D 57 REMARK 465 LYS D 58 REMARK 465 GLU D 59 REMARK 465 GLU D 60 REMARK 465 ILE D 61 REMARK 465 ILE D 62 REMARK 465 GLU D 63 REMARK 465 ALA D 64 REMARK 465 PHE D 65 REMARK 465 VAL D 66 REMARK 465 GLN D 67 REMARK 465 GLU D 68 REMARK 465 LEU D 69 REMARK 465 ARG D 70 REMARK 465 LYS D 71 REMARK 465 ARG D 72 REMARK 465 GLY D 73 REMARK 465 SER D 74 REMARK 465 LEU D 75 REMARK 465 VAL D 76 REMARK 465 PRO D 77 REMARK 465 ARG D 78 REMARK 465 GLY D 79 REMARK 465 SER D 80 REMARK 465 GLY D 81 REMARK 465 GLY D 82 REMARK 465 VAL D 83 REMARK 465 LYS D 84 REMARK 465 ASP D 468 REMARK 465 LYS D 469 REMARK 465 HIS E 26 REMARK 465 HIS E 27 REMARK 465 HIS E 28 REMARK 465 HIS E 29 REMARK 465 HIS E 30 REMARK 465 HIS E 31 REMARK 465 SER E 32 REMARK 465 SER E 33 REMARK 465 SER E 34 REMARK 465 ASP E 35 REMARK 465 TYR E 36 REMARK 465 SER E 37 REMARK 465 ASP E 38 REMARK 465 LEU E 39 REMARK 465 GLN E 40 REMARK 465 ARG E 41 REMARK 465 VAL E 42 REMARK 465 LYS E 43 REMARK 465 GLN E 44 REMARK 465 GLU E 45 REMARK 465 LEU E 46 REMARK 465 LEU E 47 REMARK 465 GLU E 48 REMARK 465 GLU E 49 REMARK 465 VAL E 50 REMARK 465 LYS E 51 REMARK 465 LYS E 52 REMARK 465 GLU E 53 REMARK 465 LEU E 54 REMARK 465 GLN E 55 REMARK 465 LYS E 56 REMARK 465 VAL E 57 REMARK 465 LYS E 58 REMARK 465 GLU E 59 REMARK 465 GLU E 60 REMARK 465 ILE E 61 REMARK 465 ILE E 62 REMARK 465 GLU E 63 REMARK 465 ALA E 64 REMARK 465 PHE E 65 REMARK 465 VAL E 66 REMARK 465 GLN E 67 REMARK 465 GLU E 68 REMARK 465 LEU E 69 REMARK 465 ARG E 70 REMARK 465 LYS E 71 REMARK 465 ARG E 72 REMARK 465 GLY E 73 REMARK 465 SER E 74 REMARK 465 LEU E 75 REMARK 465 VAL E 76 REMARK 465 PRO E 77 REMARK 465 ARG E 78 REMARK 465 GLY E 79 REMARK 465 SER E 80 REMARK 465 GLY E 81 REMARK 465 GLY E 82 REMARK 465 VAL E 83 REMARK 465 LYS E 84 REMARK 465 ASP E 468 REMARK 465 LYS E 469 REMARK 465 HIS F 26 REMARK 465 HIS F 27 REMARK 465 HIS F 28 REMARK 465 HIS F 29 REMARK 465 HIS F 30 REMARK 465 HIS F 31 REMARK 465 SER F 32 REMARK 465 SER F 33 REMARK 465 SER F 34 REMARK 465 ASP F 35 REMARK 465 TYR F 36 REMARK 465 SER F 37 REMARK 465 ASP F 38 REMARK 465 LEU F 39 REMARK 465 GLN F 40 REMARK 465 ARG F 41 REMARK 465 VAL F 42 REMARK 465 LYS F 43 REMARK 465 GLN F 44 REMARK 465 GLU F 45 REMARK 465 LEU F 46 REMARK 465 LEU F 47 REMARK 465 GLU F 48 REMARK 465 GLU F 49 REMARK 465 VAL F 50 REMARK 465 LYS F 51 REMARK 465 LYS F 52 REMARK 465 GLU F 53 REMARK 465 LEU F 54 REMARK 465 GLN F 55 REMARK 465 LYS F 56 REMARK 465 VAL F 57 REMARK 465 LYS F 58 REMARK 465 GLU F 59 REMARK 465 GLU F 60 REMARK 465 ILE F 61 REMARK 465 ILE F 62 REMARK 465 GLU F 63 REMARK 465 ALA F 64 REMARK 465 PHE F 65 REMARK 465 VAL F 66 REMARK 465 GLN F 67 REMARK 465 GLU F 68 REMARK 465 LEU F 69 REMARK 465 ARG F 70 REMARK 465 LYS F 71 REMARK 465 ARG F 72 REMARK 465 GLY F 73 REMARK 465 SER F 74 REMARK 465 LEU F 75 REMARK 465 VAL F 76 REMARK 465 PRO F 77 REMARK 465 ARG F 78 REMARK 465 GLY F 79 REMARK 465 SER F 80 REMARK 465 GLY F 81 REMARK 465 GLY F 82 REMARK 465 VAL F 83 REMARK 465 LYS F 84 REMARK 465 ASP F 468 REMARK 465 LYS F 469 REMARK 465 GLN H 1 REMARK 465 GLN I 1 REMARK 465 GLN J 1 REMARK 465 HIS K 26 REMARK 465 HIS K 27 REMARK 465 HIS K 28 REMARK 465 HIS K 29 REMARK 465 HIS K 30 REMARK 465 HIS K 31 REMARK 465 SER K 32 REMARK 465 SER K 33 REMARK 465 SER K 34 REMARK 465 ASP K 35 REMARK 465 TYR K 36 REMARK 465 SER K 37 REMARK 465 ASP K 38 REMARK 465 LEU K 39 REMARK 465 GLN K 40 REMARK 465 ARG K 41 REMARK 465 VAL K 42 REMARK 465 LYS K 43 REMARK 465 GLN K 44 REMARK 465 GLU K 45 REMARK 465 LEU K 46 REMARK 465 LEU K 47 REMARK 465 GLU K 48 REMARK 465 GLU K 49 REMARK 465 VAL K 50 REMARK 465 LYS K 51 REMARK 465 LYS K 52 REMARK 465 GLU K 53 REMARK 465 LEU K 54 REMARK 465 GLN K 55 REMARK 465 LYS K 56 REMARK 465 VAL K 57 REMARK 465 LYS K 58 REMARK 465 GLU K 59 REMARK 465 GLU K 60 REMARK 465 ILE K 61 REMARK 465 ILE K 62 REMARK 465 GLU K 63 REMARK 465 ALA K 64 REMARK 465 PHE K 65 REMARK 465 VAL K 66 REMARK 465 GLN K 67 REMARK 465 GLU K 68 REMARK 465 LEU K 69 REMARK 465 ARG K 70 REMARK 465 LYS K 71 REMARK 465 ARG K 72 REMARK 465 GLY K 73 REMARK 465 SER K 74 REMARK 465 LEU K 75 REMARK 465 VAL K 76 REMARK 465 PRO K 77 REMARK 465 ARG K 78 REMARK 465 GLY K 79 REMARK 465 SER K 80 REMARK 465 GLY K 81 REMARK 465 GLY K 82 REMARK 465 VAL K 83 REMARK 465 LYS K 84 REMARK 465 ASP K 468 REMARK 465 LYS K 469 REMARK 465 GLN O 1 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ASP L 1 CG OD1 OD2 REMARK 470 ASP M 1 CG OD1 OD2 REMARK 470 ASP N 1 CG OD1 OD2 REMARK 470 ASP P 1 CG OD1 OD2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 TYR E 253 CG TYR E 253 CD1 0.082 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 TYR E 253 CG - CD1 - CE1 ANGL. DEV. = 5.5 DEGREES REMARK 500 TYR E 253 CG - CD2 - CE2 ANGL. DEV. = -6.2 DEGREES REMARK 500 TYR E 253 CD1 - CE1 - CZ ANGL. DEV. = -6.5 DEGREES REMARK 500 TYR E 253 CZ - CE2 - CD2 ANGL. DEV. = 6.3 DEGREES REMARK 500 ARG E 301 C - N - CA ANGL. DEV. = -18.6 DEGREES REMARK 500 LEU F 100 CB - CG - CD2 ANGL. DEV. = -22.1 DEGREES REMARK 500 LEU K 158 CB - CG - CD1 ANGL. DEV. = 10.2 DEGREES REMARK 500 CYS K 446 CA - CB - SG ANGL. DEV. = 7.1 DEGREES REMARK 500 VAL O 24 CG1 - CB - CG2 ANGL. DEV. = -9.9 DEGREES REMARK 500 TYR O 34 CB - CG - CD1 ANGL. DEV. = 3.9 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN D 104 51.30 -93.15 REMARK 500 ILE D 223 79.18 51.21 REMARK 500 THR D 226 -166.11 -129.86 REMARK 500 ASP D 284 111.36 -161.76 REMARK 500 HIS D 297 34.22 -148.77 REMARK 500 SER D 400 -165.76 -127.71 REMARK 500 ASN E 104 45.74 -106.69 REMARK 500 GLU E 119 84.04 47.17 REMARK 500 THR E 148 2.98 -68.27 REMARK 500 ALA E 178 136.97 -170.14 REMARK 500 ASN E 222 74.48 -154.61 REMARK 500 ILE E 223 88.18 55.22 REMARK 500 LYS E 265 149.27 177.74 REMARK 500 ALA E 271 73.27 -153.09 REMARK 500 GLU E 278 71.92 55.35 REMARK 500 ASP E 284 110.41 -161.26 REMARK 500 SER E 286 -3.43 74.07 REMARK 500 TRP E 296 -60.32 -94.21 REMARK 500 HIS E 297 49.36 -163.85 REMARK 500 SER E 400 -137.41 -124.85 REMARK 500 ASN F 104 45.60 -97.27 REMARK 500 THR F 148 25.13 -78.32 REMARK 500 ASP F 214 152.26 173.90 REMARK 500 ASN F 222 72.73 -153.61 REMARK 500 ILE F 223 79.19 58.89 REMARK 500 ASP F 284 106.45 -164.42 REMARK 500 TRP F 296 -74.98 -85.93 REMARK 500 HIS F 297 51.31 -151.20 REMARK 500 LYS F 331 -139.01 -124.36 REMARK 500 SER F 400 -140.92 -115.59 REMARK 500 LYS H 43 105.04 79.94 REMARK 500 SER H 82B 64.33 60.51 REMARK 500 LEU H 100I 91.01 -44.99 REMARK 500 GLN I 5 116.19 -162.52 REMARK 500 ILE I 48 -75.57 -91.02 REMARK 500 SER I 56 136.70 -38.68 REMARK 500 SER I 82B 65.81 63.66 REMARK 500 THR I 100A 153.04 172.91 REMARK 500 SER J 15 7.78 94.18 REMARK 500 LYS J 43 124.84 -36.59 REMARK 500 ASP J 58 112.97 -173.69 REMARK 500 GLU J 100 67.99 -110.01 REMARK 500 ASN K 104 46.97 -94.01 REMARK 500 GLU K 119 66.75 61.30 REMARK 500 PRO K 167 100.42 -55.78 REMARK 500 CYS K 184 139.53 170.86 REMARK 500 ASN K 222 68.75 -150.33 REMARK 500 ILE K 223 79.97 69.49 REMARK 500 GLU K 278 74.17 44.37 REMARK 500 ASP K 284 110.52 -168.94 REMARK 500 REMARK 500 THIS ENTRY HAS 73 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS REMARK 500 REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES. REMARK 500 MODEL OMEGA REMARK 500 LYS J 43 GLY J 44 118.85 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG E 173 0.10 SIDE CHAIN REMARK 500 ARG F 173 0.16 SIDE CHAIN REMARK 500 ARG F 361 0.10 SIDE CHAIN REMARK 500 ARG K 173 0.13 SIDE CHAIN REMARK 500 ARG K 327 0.08 SIDE CHAIN REMARK 500 TYR N 70 0.06 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 525 REMARK 525 SOLVENT REMARK 525 REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER; REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE REMARK 525 NUMBER; I=INSERTION CODE): REMARK 525 REMARK 525 M RES CSSEQI REMARK 525 HOH E 754 DISTANCE = 6.17 ANGSTROMS REMARK 525 HOH I 244 DISTANCE = 5.91 ANGSTROMS REMARK 525 HOH K 739 DISTANCE = 6.10 ANGSTROMS REMARK 620 REMARK 620 METAL COORDINATION REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE): REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA D 503 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP D 294 O REMARK 620 2 GLY D 298 O 86.5 REMARK 620 3 ASP D 324 OD2 89.2 91.7 REMARK 620 4 GLY D 342 O 98.0 89.5 172.9 REMARK 620 5 ASN D 344 O 100.2 173.1 87.0 91.1 REMARK 620 6 HOH D 643 O 159.8 98.1 71.2 101.7 75.1 REMARK 620 N 1 2 3 4 5 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA D 504 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP D 376 OD1 REMARK 620 2 ASN D 378 OD1 89.3 REMARK 620 3 ASP D 384 OD2 172.9 97.7 REMARK 620 4 ASN D 386 O 76.7 164.6 96.2 REMARK 620 5 HOH D 606 O 91.4 85.5 90.0 101.2 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA E 504 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP E 294 O REMARK 620 2 GLY E 298 O 83.9 REMARK 620 3 GLY E 342 O 94.1 90.4 REMARK 620 4 ASN E 344 O 113.7 162.1 91.9 REMARK 620 5 HOH E 646 O 158.4 92.8 107.3 69.6 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA E 503 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP E 376 OD1 REMARK 620 2 ASP E 376 OD2 45.8 REMARK 620 3 ASN E 386 O 72.5 55.9 REMARK 620 4 HOH E 615 O 99.2 65.9 103.9 REMARK 620 N 1 2 3 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA F 503 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP F 294 O REMARK 620 2 GLY F 298 O 86.5 REMARK 620 3 GLY F 342 O 99.0 90.9 REMARK 620 4 ASN F 344 O 101.1 170.2 94.0 REMARK 620 5 HOH F 612 O 163.8 98.8 96.2 72.2 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA F 504 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP F 376 OD1 REMARK 620 2 ASN F 378 OD1 90.8 REMARK 620 3 ASP F 384 OD2 168.1 100.3 REMARK 620 4 ASN F 386 O 76.3 165.3 93.1 REMARK 620 5 HOH F 619 O 96.8 80.0 80.9 108.3 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA K 503 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP K 294 O REMARK 620 2 GLY K 298 O 87.2 REMARK 620 3 GLY K 342 O 98.6 92.8 REMARK 620 4 ASN K 344 O 99.6 172.3 90.0 REMARK 620 5 HOH K 641 O 161.2 97.6 99.4 74.8 REMARK 620 N 1 2 3 4 REMARK 620 REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL REMARK 620 CA K 504 CA REMARK 620 N RES CSSEQI ATOM REMARK 620 1 ASP K 376 OD1 REMARK 620 2 ASP K 376 OD2 44.7 REMARK 620 3 ASN K 378 OD1 85.1 106.5 REMARK 620 4 ASN K 386 O 73.4 75.6 146.9 REMARK 620 N 1 2 3 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-70264 RELATED DB: EMDB REMARK 900 NCS.1.1 FAB IN COMPLEX WITH THE SNAP OF A/CALIFORNIA/04/2009 (CA09, REMARK 900 H1N1) -- 4 FABS [C1 RECONSTRUCTION] DBREF1 9O9V D 83 469 UNP A0A024D2C1_9INFA DBREF2 9O9V D A0A024D2C1 83 469 DBREF1 9O9V E 83 469 UNP A0A024D2C1_9INFA DBREF2 9O9V E A0A024D2C1 83 469 DBREF1 9O9V F 83 469 UNP A0A024D2C1_9INFA DBREF2 9O9V F A0A024D2C1 83 469 DBREF 9O9V H 1 113 PDB 9O9V 9O9V 1 113 DBREF 9O9V I 1 113 PDB 9O9V 9O9V 1 113 DBREF 9O9V J 1 113 PDB 9O9V 9O9V 1 113 DBREF1 9O9V K 83 469 UNP A0A024D2C1_9INFA DBREF2 9O9V K A0A024D2C1 83 469 DBREF 9O9V L 1 107 PDB 9O9V 9O9V 1 107 DBREF 9O9V M 1 107 PDB 9O9V 9O9V 1 107 DBREF 9O9V N 1 107 PDB 9O9V 9O9V 1 107 DBREF 9O9V O 1 113 PDB 9O9V 9O9V 1 113 DBREF 9O9V P 1 107 PDB 9O9V 9O9V 1 107 SEQADV 9O9V HIS D 26 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS D 27 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS D 28 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS D 29 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS D 30 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS D 31 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER D 32 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER D 33 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER D 34 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP D 35 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V TYR D 36 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER D 37 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP D 38 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU D 39 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN D 40 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG D 41 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL D 42 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS D 43 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN D 44 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 45 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU D 46 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU D 47 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 48 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 49 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL D 50 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS D 51 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS D 52 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 53 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU D 54 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN D 55 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS D 56 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL D 57 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS D 58 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 59 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 60 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE D 61 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE D 62 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 63 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ALA D 64 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PHE D 65 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL D 66 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN D 67 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU D 68 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU D 69 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG D 70 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS D 71 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG D 72 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY D 73 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER D 74 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU D 75 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL D 76 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO D 77 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG D 78 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY D 79 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER D 80 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY D 81 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY D 82 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO D 99 UNP A0A024D2C ILE 99 CONFLICT SEQADV 9O9V LEU D 100 UNP A0A024D2C TYR 100 CONFLICT SEQADV 9O9V VAL D 161 UNP A0A024D2C CYS 161 CONFLICT SEQADV 9O9V SER D 165 UNP A0A024D2C GLU 165 CONFLICT SEQADV 9O9V ALA D 172 UNP A0A024D2C SER 172 CONFLICT SEQADV 9O9V ILE D 177 UNP A0A024D2C VAL 177 CONFLICT SEQADV 9O9V THR D 196 UNP A0A024D2C SER 196 CONFLICT SEQADV 9O9V ILE D 205 UNP A0A024D2C VAL 205 CONFLICT SEQADV 9O9V MET D 408 UNP A0A024D2C GLN 408 CONFLICT SEQADV 9O9V VAL D 419 UNP A0A024D2C ARG 419 CONFLICT SEQADV 9O9V THR D 453 UNP A0A024D2C VAL 453 CONFLICT SEQADV 9O9V HIS E 26 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS E 27 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS E 28 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS E 29 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS E 30 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS E 31 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER E 32 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER E 33 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER E 34 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP E 35 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V TYR E 36 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER E 37 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP E 38 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU E 39 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN E 40 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG E 41 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL E 42 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS E 43 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN E 44 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 45 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU E 46 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU E 47 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 48 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 49 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL E 50 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS E 51 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS E 52 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 53 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU E 54 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN E 55 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS E 56 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL E 57 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS E 58 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 59 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 60 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE E 61 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE E 62 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 63 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ALA E 64 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PHE E 65 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL E 66 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN E 67 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU E 68 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU E 69 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG E 70 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS E 71 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG E 72 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY E 73 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER E 74 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU E 75 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL E 76 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO E 77 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG E 78 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY E 79 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER E 80 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY E 81 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY E 82 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO E 99 UNP A0A024D2C ILE 99 CONFLICT SEQADV 9O9V LEU E 100 UNP A0A024D2C TYR 100 CONFLICT SEQADV 9O9V VAL E 161 UNP A0A024D2C CYS 161 CONFLICT SEQADV 9O9V SER E 165 UNP A0A024D2C GLU 165 CONFLICT SEQADV 9O9V ALA E 172 UNP A0A024D2C SER 172 CONFLICT SEQADV 9O9V ILE E 177 UNP A0A024D2C VAL 177 CONFLICT SEQADV 9O9V THR E 196 UNP A0A024D2C SER 196 CONFLICT SEQADV 9O9V ILE E 205 UNP A0A024D2C VAL 205 CONFLICT SEQADV 9O9V MET E 408 UNP A0A024D2C GLN 408 CONFLICT SEQADV 9O9V VAL E 419 UNP A0A024D2C ARG 419 CONFLICT SEQADV 9O9V THR E 453 UNP A0A024D2C VAL 453 CONFLICT SEQADV 9O9V HIS F 26 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS F 27 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS F 28 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS F 29 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS F 30 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS F 31 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER F 32 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER F 33 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER F 34 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP F 35 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V TYR F 36 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER F 37 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP F 38 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU F 39 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN F 40 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG F 41 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL F 42 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS F 43 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN F 44 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 45 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU F 46 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU F 47 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 48 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 49 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL F 50 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS F 51 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS F 52 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 53 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU F 54 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN F 55 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS F 56 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL F 57 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS F 58 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 59 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 60 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE F 61 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE F 62 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 63 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ALA F 64 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PHE F 65 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL F 66 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN F 67 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU F 68 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU F 69 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG F 70 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS F 71 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG F 72 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY F 73 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER F 74 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU F 75 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL F 76 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO F 77 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG F 78 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY F 79 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER F 80 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY F 81 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY F 82 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO F 99 UNP A0A024D2C ILE 99 CONFLICT SEQADV 9O9V LEU F 100 UNP A0A024D2C TYR 100 CONFLICT SEQADV 9O9V VAL F 161 UNP A0A024D2C CYS 161 CONFLICT SEQADV 9O9V SER F 165 UNP A0A024D2C GLU 165 CONFLICT SEQADV 9O9V ALA F 172 UNP A0A024D2C SER 172 CONFLICT SEQADV 9O9V ILE F 177 UNP A0A024D2C VAL 177 CONFLICT SEQADV 9O9V THR F 196 UNP A0A024D2C SER 196 CONFLICT SEQADV 9O9V ILE F 205 UNP A0A024D2C VAL 205 CONFLICT SEQADV 9O9V MET F 408 UNP A0A024D2C GLN 408 CONFLICT SEQADV 9O9V VAL F 419 UNP A0A024D2C ARG 419 CONFLICT SEQADV 9O9V THR F 453 UNP A0A024D2C VAL 453 CONFLICT SEQADV 9O9V HIS K 26 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS K 27 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS K 28 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS K 29 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS K 30 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V HIS K 31 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER K 32 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER K 33 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER K 34 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP K 35 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V TYR K 36 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER K 37 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ASP K 38 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU K 39 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN K 40 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG K 41 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL K 42 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS K 43 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN K 44 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 45 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU K 46 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU K 47 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 48 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 49 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL K 50 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS K 51 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS K 52 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 53 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU K 54 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN K 55 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS K 56 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL K 57 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS K 58 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 59 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 60 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE K 61 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ILE K 62 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 63 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ALA K 64 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PHE K 65 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL K 66 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLN K 67 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLU K 68 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU K 69 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG K 70 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LYS K 71 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG K 72 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY K 73 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER K 74 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V LEU K 75 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V VAL K 76 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO K 77 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V ARG K 78 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY K 79 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V SER K 80 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY K 81 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V GLY K 82 UNP A0A024D2C EXPRESSION TAG SEQADV 9O9V PRO K 99 UNP A0A024D2C ILE 99 CONFLICT SEQADV 9O9V LEU K 100 UNP A0A024D2C TYR 100 CONFLICT SEQADV 9O9V VAL K 161 UNP A0A024D2C CYS 161 CONFLICT SEQADV 9O9V SER K 165 UNP A0A024D2C GLU 165 CONFLICT SEQADV 9O9V ALA K 172 UNP A0A024D2C SER 172 CONFLICT SEQADV 9O9V ILE K 177 UNP A0A024D2C VAL 177 CONFLICT SEQADV 9O9V THR K 196 UNP A0A024D2C SER 196 CONFLICT SEQADV 9O9V ILE K 205 UNP A0A024D2C VAL 205 CONFLICT SEQADV 9O9V MET K 408 UNP A0A024D2C GLN 408 CONFLICT SEQADV 9O9V VAL K 419 UNP A0A024D2C ARG 419 CONFLICT SEQADV 9O9V THR K 453 UNP A0A024D2C VAL 453 CONFLICT SEQRES 1 D 444 HIS HIS HIS HIS HIS HIS SER SER SER ASP TYR SER ASP SEQRES 2 D 444 LEU GLN ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS SEQRES 3 D 444 LYS GLU LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA SEQRES 4 D 444 PHE VAL GLN GLU LEU ARG LYS ARG GLY SER LEU VAL PRO SEQRES 5 D 444 ARG GLY SER GLY GLY VAL LYS LEU ALA GLY ASN SER SER SEQRES 6 D 444 LEU CYS PRO VAL SER GLY TRP ALA PRO LEU SER LYS ASP SEQRES 7 D 444 ASN SER VAL ARG ILE GLY SER LYS GLY ASP VAL PHE VAL SEQRES 8 D 444 ILE ARG GLU PRO PHE ILE SER CYS SER PRO LEU GLU CYS SEQRES 9 D 444 ARG THR PHE PHE LEU THR GLN GLY ALA LEU LEU ASN ASP SEQRES 10 D 444 LYS HIS SER ASN GLY THR ILE LYS ASP ARG SER PRO TYR SEQRES 11 D 444 ARG THR LEU MET SER VAL PRO ILE GLY SER VAL PRO SER SEQRES 12 D 444 PRO TYR ASN ALA ARG PHE GLU SER ILE ALA TRP SER ALA SEQRES 13 D 444 SER ALA CYS HIS ASP GLY ILE ASN TRP LEU THR ILE GLY SEQRES 14 D 444 ILE THR GLY PRO ASP ASN GLY ALA VAL ALA ILE LEU LYS SEQRES 15 D 444 TYR ASN GLY ILE ILE THR ASP THR ILE LYS SER TRP ARG SEQRES 16 D 444 ASN ASN ILE LEU ARG THR GLN GLU SER GLU CYS ALA CYS SEQRES 17 D 444 VAL ASN GLY SER CYS PHE THR VAL MET THR ASP GLY PRO SEQRES 18 D 444 SER ASN GLY GLN ALA SER TYR LYS ILE PHE ARG ILE GLU SEQRES 19 D 444 LYS GLY LYS ILE VAL LYS SER VAL GLU MET ASN ALA PRO SEQRES 20 D 444 ASN TYR HIS TYR GLU GLU CYS SER CYS TYR PRO ASP SER SEQRES 21 D 444 SER GLU ILE THR CYS VAL CYS ARG ASP ASN TRP HIS GLY SEQRES 22 D 444 SER ASN ARG PRO TRP VAL SER PHE ASN GLN ASN LEU GLU SEQRES 23 D 444 TYR GLN ILE GLY TYR ILE CYS SER GLY ILE PHE GLY ASP SEQRES 24 D 444 ASN PRO ARG PRO ASN ASP LYS THR GLY SER CYS GLY PRO SEQRES 25 D 444 VAL SER SER ASN GLY ALA ASN GLY VAL LYS GLY PHE SER SEQRES 26 D 444 PHE LYS TYR GLY ASN GLY VAL TRP ILE GLY ARG THR LYS SEQRES 27 D 444 SER ILE SER SER ARG ASN GLY PHE GLU MET ILE TRP ASP SEQRES 28 D 444 PRO ASN GLY TRP THR GLY THR ASP ASN ASN PHE SER ILE SEQRES 29 D 444 LYS GLN ASP ILE VAL GLY ILE ASN GLU TRP SER GLY TYR SEQRES 30 D 444 SER GLY SER PHE VAL MET HIS PRO GLU LEU THR GLY LEU SEQRES 31 D 444 ASP CYS ILE VAL PRO CYS PHE TRP VAL GLU LEU ILE ARG SEQRES 32 D 444 GLY ARG PRO LYS GLU ASN THR ILE TRP THR SER GLY SER SEQRES 33 D 444 SER ILE SER PHE CYS GLY VAL ASN SER ASP THR THR GLY SEQRES 34 D 444 TRP SER TRP PRO ASP GLY ALA GLU LEU PRO PHE THR ILE SEQRES 35 D 444 ASP LYS SEQRES 1 E 444 HIS HIS HIS HIS HIS HIS SER SER SER ASP TYR SER ASP SEQRES 2 E 444 LEU GLN ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS SEQRES 3 E 444 LYS GLU LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA SEQRES 4 E 444 PHE VAL GLN GLU LEU ARG LYS ARG GLY SER LEU VAL PRO SEQRES 5 E 444 ARG GLY SER GLY GLY VAL LYS LEU ALA GLY ASN SER SER SEQRES 6 E 444 LEU CYS PRO VAL SER GLY TRP ALA PRO LEU SER LYS ASP SEQRES 7 E 444 ASN SER VAL ARG ILE GLY SER LYS GLY ASP VAL PHE VAL SEQRES 8 E 444 ILE ARG GLU PRO PHE ILE SER CYS SER PRO LEU GLU CYS SEQRES 9 E 444 ARG THR PHE PHE LEU THR GLN GLY ALA LEU LEU ASN ASP SEQRES 10 E 444 LYS HIS SER ASN GLY THR ILE LYS ASP ARG SER PRO TYR SEQRES 11 E 444 ARG THR LEU MET SER VAL PRO ILE GLY SER VAL PRO SER SEQRES 12 E 444 PRO TYR ASN ALA ARG PHE GLU SER ILE ALA TRP SER ALA SEQRES 13 E 444 SER ALA CYS HIS ASP GLY ILE ASN TRP LEU THR ILE GLY SEQRES 14 E 444 ILE THR GLY PRO ASP ASN GLY ALA VAL ALA ILE LEU LYS SEQRES 15 E 444 TYR ASN GLY ILE ILE THR ASP THR ILE LYS SER TRP ARG SEQRES 16 E 444 ASN ASN ILE LEU ARG THR GLN GLU SER GLU CYS ALA CYS SEQRES 17 E 444 VAL ASN GLY SER CYS PHE THR VAL MET THR ASP GLY PRO SEQRES 18 E 444 SER ASN GLY GLN ALA SER TYR LYS ILE PHE ARG ILE GLU SEQRES 19 E 444 LYS GLY LYS ILE VAL LYS SER VAL GLU MET ASN ALA PRO SEQRES 20 E 444 ASN TYR HIS TYR GLU GLU CYS SER CYS TYR PRO ASP SER SEQRES 21 E 444 SER GLU ILE THR CYS VAL CYS ARG ASP ASN TRP HIS GLY SEQRES 22 E 444 SER ASN ARG PRO TRP VAL SER PHE ASN GLN ASN LEU GLU SEQRES 23 E 444 TYR GLN ILE GLY TYR ILE CYS SER GLY ILE PHE GLY ASP SEQRES 24 E 444 ASN PRO ARG PRO ASN ASP LYS THR GLY SER CYS GLY PRO SEQRES 25 E 444 VAL SER SER ASN GLY ALA ASN GLY VAL LYS GLY PHE SER SEQRES 26 E 444 PHE LYS TYR GLY ASN GLY VAL TRP ILE GLY ARG THR LYS SEQRES 27 E 444 SER ILE SER SER ARG ASN GLY PHE GLU MET ILE TRP ASP SEQRES 28 E 444 PRO ASN GLY TRP THR GLY THR ASP ASN ASN PHE SER ILE SEQRES 29 E 444 LYS GLN ASP ILE VAL GLY ILE ASN GLU TRP SER GLY TYR SEQRES 30 E 444 SER GLY SER PHE VAL MET HIS PRO GLU LEU THR GLY LEU SEQRES 31 E 444 ASP CYS ILE VAL PRO CYS PHE TRP VAL GLU LEU ILE ARG SEQRES 32 E 444 GLY ARG PRO LYS GLU ASN THR ILE TRP THR SER GLY SER SEQRES 33 E 444 SER ILE SER PHE CYS GLY VAL ASN SER ASP THR THR GLY SEQRES 34 E 444 TRP SER TRP PRO ASP GLY ALA GLU LEU PRO PHE THR ILE SEQRES 35 E 444 ASP LYS SEQRES 1 F 444 HIS HIS HIS HIS HIS HIS SER SER SER ASP TYR SER ASP SEQRES 2 F 444 LEU GLN ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS SEQRES 3 F 444 LYS GLU LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA SEQRES 4 F 444 PHE VAL GLN GLU LEU ARG LYS ARG GLY SER LEU VAL PRO SEQRES 5 F 444 ARG GLY SER GLY GLY VAL LYS LEU ALA GLY ASN SER SER SEQRES 6 F 444 LEU CYS PRO VAL SER GLY TRP ALA PRO LEU SER LYS ASP SEQRES 7 F 444 ASN SER VAL ARG ILE GLY SER LYS GLY ASP VAL PHE VAL SEQRES 8 F 444 ILE ARG GLU PRO PHE ILE SER CYS SER PRO LEU GLU CYS SEQRES 9 F 444 ARG THR PHE PHE LEU THR GLN GLY ALA LEU LEU ASN ASP SEQRES 10 F 444 LYS HIS SER ASN GLY THR ILE LYS ASP ARG SER PRO TYR SEQRES 11 F 444 ARG THR LEU MET SER VAL PRO ILE GLY SER VAL PRO SER SEQRES 12 F 444 PRO TYR ASN ALA ARG PHE GLU SER ILE ALA TRP SER ALA SEQRES 13 F 444 SER ALA CYS HIS ASP GLY ILE ASN TRP LEU THR ILE GLY SEQRES 14 F 444 ILE THR GLY PRO ASP ASN GLY ALA VAL ALA ILE LEU LYS SEQRES 15 F 444 TYR ASN GLY ILE ILE THR ASP THR ILE LYS SER TRP ARG SEQRES 16 F 444 ASN ASN ILE LEU ARG THR GLN GLU SER GLU CYS ALA CYS SEQRES 17 F 444 VAL ASN GLY SER CYS PHE THR VAL MET THR ASP GLY PRO SEQRES 18 F 444 SER ASN GLY GLN ALA SER TYR LYS ILE PHE ARG ILE GLU SEQRES 19 F 444 LYS GLY LYS ILE VAL LYS SER VAL GLU MET ASN ALA PRO SEQRES 20 F 444 ASN TYR HIS TYR GLU GLU CYS SER CYS TYR PRO ASP SER SEQRES 21 F 444 SER GLU ILE THR CYS VAL CYS ARG ASP ASN TRP HIS GLY SEQRES 22 F 444 SER ASN ARG PRO TRP VAL SER PHE ASN GLN ASN LEU GLU SEQRES 23 F 444 TYR GLN ILE GLY TYR ILE CYS SER GLY ILE PHE GLY ASP SEQRES 24 F 444 ASN PRO ARG PRO ASN ASP LYS THR GLY SER CYS GLY PRO SEQRES 25 F 444 VAL SER SER ASN GLY ALA ASN GLY VAL LYS GLY PHE SER SEQRES 26 F 444 PHE LYS TYR GLY ASN GLY VAL TRP ILE GLY ARG THR LYS SEQRES 27 F 444 SER ILE SER SER ARG ASN GLY PHE GLU MET ILE TRP ASP SEQRES 28 F 444 PRO ASN GLY TRP THR GLY THR ASP ASN ASN PHE SER ILE SEQRES 29 F 444 LYS GLN ASP ILE VAL GLY ILE ASN GLU TRP SER GLY TYR SEQRES 30 F 444 SER GLY SER PHE VAL MET HIS PRO GLU LEU THR GLY LEU SEQRES 31 F 444 ASP CYS ILE VAL PRO CYS PHE TRP VAL GLU LEU ILE ARG SEQRES 32 F 444 GLY ARG PRO LYS GLU ASN THR ILE TRP THR SER GLY SER SEQRES 33 F 444 SER ILE SER PHE CYS GLY VAL ASN SER ASP THR THR GLY SEQRES 34 F 444 TRP SER TRP PRO ASP GLY ALA GLU LEU PRO PHE THR ILE SEQRES 35 F 444 ASP LYS SEQRES 1 H 127 GLN VAL GLN LEU GLN GLU SER GLY PRO ARG LEU VAL LYS SEQRES 2 H 127 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 H 127 GLU SER ILE SER SER GLY GLY TYR TYR TRP THR TRP ILE SEQRES 4 H 127 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY ASN SEQRES 5 H 127 ILE PHE ASP THR GLY SER THR ASP TYR SER PRO SER LEU SEQRES 6 H 127 LYS THR ARG LEU THR ILE SER ILE ASP THR SER LYS ASN SEQRES 7 H 127 GLN PHE TYR LEU ARG LEU ASN SER ALA THR ALA ALA ASP SEQRES 8 H 127 THR ALA VAL TYR TYR CYS ALA ARG VAL GLY PHE SER LEU SEQRES 9 H 127 GLU THR ASP ARG PRO TYR TYR LEU GLY LEU ASP VAL TRP SEQRES 10 H 127 GLY GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 I 127 GLN VAL GLN LEU GLN GLU SER GLY PRO ARG LEU VAL LYS SEQRES 2 I 127 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 I 127 GLU SER ILE SER SER GLY GLY TYR TYR TRP THR TRP ILE SEQRES 4 I 127 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY ASN SEQRES 5 I 127 ILE PHE ASP THR GLY SER THR ASP TYR SER PRO SER LEU SEQRES 6 I 127 LYS THR ARG LEU THR ILE SER ILE ASP THR SER LYS ASN SEQRES 7 I 127 GLN PHE TYR LEU ARG LEU ASN SER ALA THR ALA ALA ASP SEQRES 8 I 127 THR ALA VAL TYR TYR CYS ALA ARG VAL GLY PHE SER LEU SEQRES 9 I 127 GLU THR ASP ARG PRO TYR TYR LEU GLY LEU ASP VAL TRP SEQRES 10 I 127 GLY GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 J 127 GLN VAL GLN LEU GLN GLU SER GLY PRO ARG LEU VAL LYS SEQRES 2 J 127 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 J 127 GLU SER ILE SER SER GLY GLY TYR TYR TRP THR TRP ILE SEQRES 4 J 127 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY ASN SEQRES 5 J 127 ILE PHE ASP THR GLY SER THR ASP TYR SER PRO SER LEU SEQRES 6 J 127 LYS THR ARG LEU THR ILE SER ILE ASP THR SER LYS ASN SEQRES 7 J 127 GLN PHE TYR LEU ARG LEU ASN SER ALA THR ALA ALA ASP SEQRES 8 J 127 THR ALA VAL TYR TYR CYS ALA ARG VAL GLY PHE SER LEU SEQRES 9 J 127 GLU THR ASP ARG PRO TYR TYR LEU GLY LEU ASP VAL TRP SEQRES 10 J 127 GLY GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 K 444 HIS HIS HIS HIS HIS HIS SER SER SER ASP TYR SER ASP SEQRES 2 K 444 LEU GLN ARG VAL LYS GLN GLU LEU LEU GLU GLU VAL LYS SEQRES 3 K 444 LYS GLU LEU GLN LYS VAL LYS GLU GLU ILE ILE GLU ALA SEQRES 4 K 444 PHE VAL GLN GLU LEU ARG LYS ARG GLY SER LEU VAL PRO SEQRES 5 K 444 ARG GLY SER GLY GLY VAL LYS LEU ALA GLY ASN SER SER SEQRES 6 K 444 LEU CYS PRO VAL SER GLY TRP ALA PRO LEU SER LYS ASP SEQRES 7 K 444 ASN SER VAL ARG ILE GLY SER LYS GLY ASP VAL PHE VAL SEQRES 8 K 444 ILE ARG GLU PRO PHE ILE SER CYS SER PRO LEU GLU CYS SEQRES 9 K 444 ARG THR PHE PHE LEU THR GLN GLY ALA LEU LEU ASN ASP SEQRES 10 K 444 LYS HIS SER ASN GLY THR ILE LYS ASP ARG SER PRO TYR SEQRES 11 K 444 ARG THR LEU MET SER VAL PRO ILE GLY SER VAL PRO SER SEQRES 12 K 444 PRO TYR ASN ALA ARG PHE GLU SER ILE ALA TRP SER ALA SEQRES 13 K 444 SER ALA CYS HIS ASP GLY ILE ASN TRP LEU THR ILE GLY SEQRES 14 K 444 ILE THR GLY PRO ASP ASN GLY ALA VAL ALA ILE LEU LYS SEQRES 15 K 444 TYR ASN GLY ILE ILE THR ASP THR ILE LYS SER TRP ARG SEQRES 16 K 444 ASN ASN ILE LEU ARG THR GLN GLU SER GLU CYS ALA CYS SEQRES 17 K 444 VAL ASN GLY SER CYS PHE THR VAL MET THR ASP GLY PRO SEQRES 18 K 444 SER ASN GLY GLN ALA SER TYR LYS ILE PHE ARG ILE GLU SEQRES 19 K 444 LYS GLY LYS ILE VAL LYS SER VAL GLU MET ASN ALA PRO SEQRES 20 K 444 ASN TYR HIS TYR GLU GLU CYS SER CYS TYR PRO ASP SER SEQRES 21 K 444 SER GLU ILE THR CYS VAL CYS ARG ASP ASN TRP HIS GLY SEQRES 22 K 444 SER ASN ARG PRO TRP VAL SER PHE ASN GLN ASN LEU GLU SEQRES 23 K 444 TYR GLN ILE GLY TYR ILE CYS SER GLY ILE PHE GLY ASP SEQRES 24 K 444 ASN PRO ARG PRO ASN ASP LYS THR GLY SER CYS GLY PRO SEQRES 25 K 444 VAL SER SER ASN GLY ALA ASN GLY VAL LYS GLY PHE SER SEQRES 26 K 444 PHE LYS TYR GLY ASN GLY VAL TRP ILE GLY ARG THR LYS SEQRES 27 K 444 SER ILE SER SER ARG ASN GLY PHE GLU MET ILE TRP ASP SEQRES 28 K 444 PRO ASN GLY TRP THR GLY THR ASP ASN ASN PHE SER ILE SEQRES 29 K 444 LYS GLN ASP ILE VAL GLY ILE ASN GLU TRP SER GLY TYR SEQRES 30 K 444 SER GLY SER PHE VAL MET HIS PRO GLU LEU THR GLY LEU SEQRES 31 K 444 ASP CYS ILE VAL PRO CYS PHE TRP VAL GLU LEU ILE ARG SEQRES 32 K 444 GLY ARG PRO LYS GLU ASN THR ILE TRP THR SER GLY SER SEQRES 33 K 444 SER ILE SER PHE CYS GLY VAL ASN SER ASP THR THR GLY SEQRES 34 K 444 TRP SER TRP PRO ASP GLY ALA GLU LEU PRO PHE THR ILE SEQRES 35 K 444 ASP LYS SEQRES 1 L 112 ASP ILE VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 L 112 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 L 112 GLN SER LEU LEU HIS SER ASN GLY TYR THR TYR LEU ASP SEQRES 4 L 112 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 L 112 ILE SER PHE THR SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 L 112 ARG PHE SER GLY SER GLY SER GLY THR TYR PHE THR LEU SEQRES 7 L 112 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 L 112 TYR CYS MET GLN ALA VAL GLN THR PRO TRP THR PHE GLY SEQRES 9 L 112 GLN GLY THR LYS VAL GLU ILE LYS SEQRES 1 M 112 ASP ILE VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 M 112 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 M 112 GLN SER LEU LEU HIS SER ASN GLY TYR THR TYR LEU ASP SEQRES 4 M 112 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 M 112 ILE SER PHE THR SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 M 112 ARG PHE SER GLY SER GLY SER GLY THR TYR PHE THR LEU SEQRES 7 M 112 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 M 112 TYR CYS MET GLN ALA VAL GLN THR PRO TRP THR PHE GLY SEQRES 9 M 112 GLN GLY THR LYS VAL GLU ILE LYS SEQRES 1 N 112 ASP ILE VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 N 112 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 N 112 GLN SER LEU LEU HIS SER ASN GLY TYR THR TYR LEU ASP SEQRES 4 N 112 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 N 112 ILE SER PHE THR SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 N 112 ARG PHE SER GLY SER GLY SER GLY THR TYR PHE THR LEU SEQRES 7 N 112 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 N 112 TYR CYS MET GLN ALA VAL GLN THR PRO TRP THR PHE GLY SEQRES 9 N 112 GLN GLY THR LYS VAL GLU ILE LYS SEQRES 1 O 127 GLN VAL GLN LEU GLN GLU SER GLY PRO ARG LEU VAL LYS SEQRES 2 O 127 PRO SER GLU THR LEU SER LEU THR CYS SER VAL SER GLY SEQRES 3 O 127 GLU SER ILE SER SER GLY GLY TYR TYR TRP THR TRP ILE SEQRES 4 O 127 ARG GLN HIS PRO GLY LYS GLY LEU GLU TRP ILE GLY ASN SEQRES 5 O 127 ILE PHE ASP THR GLY SER THR ASP TYR SER PRO SER LEU SEQRES 6 O 127 LYS THR ARG LEU THR ILE SER ILE ASP THR SER LYS ASN SEQRES 7 O 127 GLN PHE TYR LEU ARG LEU ASN SER ALA THR ALA ALA ASP SEQRES 8 O 127 THR ALA VAL TYR TYR CYS ALA ARG VAL GLY PHE SER LEU SEQRES 9 O 127 GLU THR ASP ARG PRO TYR TYR LEU GLY LEU ASP VAL TRP SEQRES 10 O 127 GLY GLN GLY THR THR VAL THR VAL SER SER SEQRES 1 P 112 ASP ILE VAL MET THR GLN SER PRO LEU SER LEU PRO VAL SEQRES 2 P 112 THR PRO GLY GLU PRO ALA SER ILE SER CYS ARG SER SER SEQRES 3 P 112 GLN SER LEU LEU HIS SER ASN GLY TYR THR TYR LEU ASP SEQRES 4 P 112 TRP TYR LEU GLN LYS PRO GLY GLN SER PRO GLN LEU LEU SEQRES 5 P 112 ILE SER PHE THR SER ASN ARG ALA SER GLY VAL PRO ASP SEQRES 6 P 112 ARG PHE SER GLY SER GLY SER GLY THR TYR PHE THR LEU SEQRES 7 P 112 LYS ILE SER ARG VAL GLU ALA GLU ASP VAL GLY VAL TYR SEQRES 8 P 112 TYR CYS MET GLN ALA VAL GLN THR PRO TRP THR PHE GLY SEQRES 9 P 112 GLN GLY THR LYS VAL GLU ILE LYS HET NAG A 1 14 HET NAG A 2 14 HET BMA A 3 11 HET NAG B 1 14 HET NAG B 2 14 HET BMA B 3 11 HET NAG C 1 14 HET NAG C 2 14 HET BMA C 3 11 HET NAG G 1 14 HET NAG G 2 14 HET BMA G 3 11 HET NAG D 501 14 HET NAG D 502 14 HET CA D 503 1 HET CA D 504 1 HET NAG E 501 14 HET NAG E 502 14 HET CA E 503 1 HET CA E 504 1 HET NAG F 501 14 HET NAG F 502 14 HET CA F 503 1 HET CA F 504 1 HET NAG K 501 14 HET NAG K 502 14 HET CA K 503 1 HET CA K 504 1 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM CA CALCIUM ION HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 13 NAG 16(C8 H15 N O6) FORMUL 13 BMA 4(C6 H12 O6) FORMUL 19 CA 8(CA 2+) FORMUL 33 HOH *918(H2 O) HELIX 1 AA1 ASN D 104 GLY D 109 1 6 HELIX 2 AA2 ASP D 142 ASN D 146 5 5 HELIX 3 AA3 HIS D 409 GLY D 414 1 6 HELIX 4 AA4 ASN E 104 GLY E 109 1 6 HELIX 5 AA5 ASP E 142 ASN E 146 5 5 HELIX 6 AA6 HIS E 409 GLY E 414 1 6 HELIX 7 AA7 ARG F 107 LYS F 111 5 5 HELIX 8 AA8 ASP F 142 ASN F 146 5 5 HELIX 9 AA9 HIS F 409 GLY F 414 1 6 HELIX 10 AB1 THR H 83 THR H 87 5 5 HELIX 11 AB2 SER I 60 LYS I 64 5 5 HELIX 12 AB3 THR I 83 THR I 87 5 5 HELIX 13 AB4 THR J 83 THR J 87 5 5 HELIX 14 AB5 ASN K 104 GLY K 109 1 6 HELIX 15 AB6 ASP K 142 ASN K 146 5 5 HELIX 16 AB7 HIS K 409 GLY K 414 1 6 HELIX 17 AB8 GLU L 79 VAL L 83 5 5 HELIX 18 AB9 GLU M 79 VAL M 83 5 5 HELIX 19 AC1 GLU N 79 VAL N 83 5 5 HELIX 20 AC2 THR O 83 THR O 87 5 5 HELIX 21 AC3 GLU P 79 VAL P 83 5 5 SHEET 1 AA1 4 GLY D 96 LYS D 102 0 SHEET 2 AA1 4 THR D 438 VAL D 448 -1 O SER D 444 N LEU D 100 SHEET 3 AA1 4 VAL D 419 GLY D 429 -1 N ARG D 428 O SER D 439 SHEET 4 AA1 4 SER D 403 MET D 408 -1 N GLY D 404 O TRP D 423 SHEET 1 AA2 4 PHE D 115 CYS D 124 0 SHEET 2 AA2 4 CYS D 129 LEU D 139 -1 O PHE D 132 N PHE D 121 SHEET 3 AA2 4 THR D 157 PRO D 162 -1 O MET D 159 N PHE D 133 SHEET 4 AA2 4 ARG D 173 ILE D 177 -1 O SER D 176 N LEU D 158 SHEET 1 AA3 4 SER D 180 HIS D 185 0 SHEET 2 AA3 4 TRP D 190 THR D 196 -1 O LEU D 191 N CYS D 184 SHEET 3 AA3 4 VAL D 203 TYR D 208 -1 O ILE D 205 N GLY D 194 SHEET 4 AA3 4 ILE D 211 LYS D 217 -1 O ASP D 214 N LEU D 206 SHEET 1 AA4 4 ALA D 232 VAL D 234 0 SHEET 2 AA4 4 SER D 237 ASP D 244 -1 O PHE D 239 N ALA D 232 SHEET 3 AA4 4 SER D 252 GLU D 259 -1 O ILE D 258 N CYS D 238 SHEET 4 AA4 4 LYS D 262 GLU D 268 -1 O VAL D 267 N ILE D 255 SHEET 1 AA5 4 GLU D 277 ASP D 284 0 SHEET 2 AA5 4 GLU D 287 ARG D 293 -1 O ARG D 293 N GLU D 277 SHEET 3 AA5 4 PRO D 302 PHE D 306 -1 O PHE D 306 N ILE D 288 SHEET 4 AA5 4 TYR D 312 TYR D 316 -1 O GLY D 315 N TRP D 303 SHEET 1 AA6 4 SER D 350 TYR D 353 0 SHEET 2 AA6 4 GLY D 356 ARG D 361 -1 O TRP D 358 N PHE D 351 SHEET 3 AA6 4 ASN D 369 ASP D 376 -1 O ILE D 374 N ILE D 359 SHEET 4 AA6 4 ILE D 389 TRP D 399 -1 O GLN D 391 N MET D 373 SHEET 1 AA7 4 GLY E 96 LYS E 102 0 SHEET 2 AA7 4 THR E 438 VAL E 448 -1 O SER E 444 N LEU E 100 SHEET 3 AA7 4 VAL E 419 GLY E 429 -1 N ARG E 428 O SER E 439 SHEET 4 AA7 4 SER E 403 MET E 408 -1 N PHE E 406 O CYS E 421 SHEET 1 AA8 4 PHE E 115 CYS E 124 0 SHEET 2 AA8 4 CYS E 129 LEU E 139 -1 O PHE E 132 N PHE E 121 SHEET 3 AA8 4 THR E 157 PRO E 162 -1 O MET E 159 N PHE E 133 SHEET 4 AA8 4 ARG E 173 ILE E 177 -1 O GLU E 175 N LEU E 158 SHEET 1 AA9 4 SER E 180 HIS E 185 0 SHEET 2 AA9 4 TRP E 190 THR E 196 -1 O LEU E 191 N CYS E 184 SHEET 3 AA9 4 VAL E 203 TYR E 208 -1 O ILE E 205 N GLY E 194 SHEET 4 AA9 4 ILE E 211 LYS E 217 -1 O THR E 213 N LEU E 206 SHEET 1 AB1 3 ARG E 225 THR E 226 0 SHEET 2 AB1 3 SER E 237 ASP E 244 -1 O THR E 243 N ARG E 225 SHEET 3 AB1 3 ALA E 232 VAL E 234 -1 N VAL E 234 O SER E 237 SHEET 1 AB2 4 ARG E 225 THR E 226 0 SHEET 2 AB2 4 SER E 237 ASP E 244 -1 O THR E 243 N ARG E 225 SHEET 3 AB2 4 SER E 252 GLU E 259 -1 O ILE E 258 N CYS E 238 SHEET 4 AB2 4 LYS E 262 GLU E 268 -1 O VAL E 267 N ILE E 255 SHEET 1 AB3 4 GLU E 277 ASP E 284 0 SHEET 2 AB3 4 GLU E 287 ARG E 293 -1 O ARG E 293 N GLU E 277 SHEET 3 AB3 4 PRO E 302 PHE E 306 -1 O VAL E 304 N CYS E 290 SHEET 4 AB3 4 TYR E 312 TYR E 316 -1 O GLY E 315 N TRP E 303 SHEET 1 AB4 4 SER E 350 TYR E 353 0 SHEET 2 AB4 4 GLY E 356 ARG E 361 -1 O GLY E 356 N TYR E 353 SHEET 3 AB4 4 ASN E 369 ASP E 376 -1 O ASP E 376 N VAL E 357 SHEET 4 AB4 4 ILE E 389 TRP E 399 -1 O GLU E 398 N GLY E 370 SHEET 1 AB5 4 GLY F 96 ASP F 103 0 SHEET 2 AB5 4 THR F 438 VAL F 448 -1 O CYS F 446 N ALA F 98 SHEET 3 AB5 4 VAL F 419 GLY F 429 -1 N LEU F 426 O SER F 441 SHEET 4 AB5 4 SER F 403 MET F 408 -1 N GLY F 404 O TRP F 423 SHEET 1 AB6 4 PHE F 115 CYS F 124 0 SHEET 2 AB6 4 CYS F 129 LEU F 139 -1 O ALA F 138 N VAL F 116 SHEET 3 AB6 4 THR F 157 PRO F 162 -1 O MET F 159 N PHE F 133 SHEET 4 AB6 4 ARG F 173 ILE F 177 -1 O SER F 176 N LEU F 158 SHEET 1 AB7 4 SER F 180 HIS F 185 0 SHEET 2 AB7 4 TRP F 190 THR F 196 -1 O ILE F 193 N SER F 182 SHEET 3 AB7 4 VAL F 203 TYR F 208 -1 O ILE F 205 N GLY F 194 SHEET 4 AB7 4 ILE F 211 LYS F 217 -1 O ASP F 214 N LEU F 206 SHEET 1 AB8 4 ALA F 232 VAL F 234 0 SHEET 2 AB8 4 SER F 237 ASP F 244 -1 O SER F 237 N VAL F 234 SHEET 3 AB8 4 SER F 252 GLU F 259 -1 O ILE F 258 N CYS F 238 SHEET 4 AB8 4 LYS F 262 GLU F 268 -1 O VAL F 267 N ILE F 255 SHEET 1 AB9 4 GLU F 277 ASP F 284 0 SHEET 2 AB9 4 GLU F 287 ARG F 293 -1 O ARG F 293 N GLU F 277 SHEET 3 AB9 4 PRO F 302 PHE F 306 -1 O VAL F 304 N CYS F 290 SHEET 4 AB9 4 TYR F 312 TYR F 316 -1 O GLN F 313 N SER F 305 SHEET 1 AC1 4 SER F 350 TYR F 353 0 SHEET 2 AC1 4 GLY F 356 ARG F 361 -1 O TRP F 358 N PHE F 351 SHEET 3 AC1 4 ASN F 369 ASP F 376 -1 O ILE F 374 N ILE F 359 SHEET 4 AC1 4 ILE F 389 TRP F 399 -1 O GLN F 391 N MET F 373 SHEET 1 AC2 4 GLN H 3 SER H 7 0 SHEET 2 AC2 4 LEU H 18 SER H 25 -1 O THR H 21 N SER H 7 SHEET 3 AC2 4 GLN H 77 LEU H 82 -1 O LEU H 80 N LEU H 20 SHEET 4 AC2 4 LEU H 67 ASP H 72 -1 N ASP H 72 O GLN H 77 SHEET 1 AC3 4 LEU H 11 VAL H 12 0 SHEET 2 AC3 4 THR H 107 VAL H 111 1 O THR H 110 N VAL H 12 SHEET 3 AC3 4 ALA H 88 SER H 98 -1 N TYR H 90 O THR H 107 SHEET 4 AC3 4 TYR H 100E TYR H 100F-1 O TYR H 100E N SER H 98 SHEET 1 AC4 5 THR H 57 TYR H 59 0 SHEET 2 AC4 5 LEU H 45 ILE H 51 -1 N ASN H 50 O ASP H 58 SHEET 3 AC4 5 TYR H 34 GLN H 39 -1 N TRP H 35A O ILE H 51 SHEET 4 AC4 5 ALA H 88 SER H 98 -1 O VAL H 95 N TYR H 35 SHEET 5 AC4 5 VAL H 102 TRP H 103 -1 O VAL H 102 N ARG H 94 SHEET 1 AC5 4 GLN I 3 SER I 7 0 SHEET 2 AC5 4 LEU I 18 SER I 25 -1 O THR I 21 N SER I 7 SHEET 3 AC5 4 GLN I 77 LEU I 82 -1 O LEU I 80 N LEU I 20 SHEET 4 AC5 4 LEU I 67 ASP I 72 -1 N SER I 70 O TYR I 79 SHEET 1 AC6 6 LEU I 11 VAL I 12 0 SHEET 2 AC6 6 THR I 107 VAL I 111 1 O THR I 110 N VAL I 12 SHEET 3 AC6 6 ALA I 88 SER I 98 -1 N TYR I 90 O THR I 107 SHEET 4 AC6 6 TYR I 34 GLN I 39 -1 N ILE I 37 O TYR I 91 SHEET 5 AC6 6 LEU I 45 ILE I 51 -1 O ILE I 51 N TRP I 35A SHEET 6 AC6 6 THR I 57 ASP I 58 -1 O ASP I 58 N ASN I 50 SHEET 1 AC7 4 LEU I 11 VAL I 12 0 SHEET 2 AC7 4 THR I 107 VAL I 111 1 O THR I 110 N VAL I 12 SHEET 3 AC7 4 ALA I 88 SER I 98 -1 N TYR I 90 O THR I 107 SHEET 4 AC7 4 TYR I 100E TRP I 103 -1 O LEU I 100G N GLY I 96 SHEET 1 AC8 4 GLN J 3 SER J 7 0 SHEET 2 AC8 4 LEU J 18 SER J 25 -1 O THR J 21 N SER J 7 SHEET 3 AC8 4 GLN J 77 LEU J 82 -1 O LEU J 82 N LEU J 18 SHEET 4 AC8 4 LEU J 67 ASP J 72 -1 N SER J 70 O TYR J 79 SHEET 1 AC9 6 LEU J 11 VAL J 12 0 SHEET 2 AC9 6 THR J 107 VAL J 111 1 O THR J 110 N VAL J 12 SHEET 3 AC9 6 ALA J 88 SER J 98 -1 N TYR J 90 O THR J 107 SHEET 4 AC9 6 TYR J 34 GLN J 39 -1 N ILE J 37 O TYR J 91 SHEET 5 AC9 6 LEU J 45 ILE J 51 -1 O ILE J 51 N TRP J 35A SHEET 6 AC9 6 THR J 57 TYR J 59 -1 O ASP J 58 N ASN J 50 SHEET 1 AD1 4 LEU J 11 VAL J 12 0 SHEET 2 AD1 4 THR J 107 VAL J 111 1 O THR J 110 N VAL J 12 SHEET 3 AD1 4 ALA J 88 SER J 98 -1 N TYR J 90 O THR J 107 SHEET 4 AD1 4 TYR J 100E TRP J 103 -1 O LEU J 100G N GLY J 96 SHEET 1 AD2 4 GLY K 96 LYS K 102 0 SHEET 2 AD2 4 THR K 438 VAL K 448 -1 O VAL K 448 N GLY K 96 SHEET 3 AD2 4 VAL K 419 GLY K 429 -1 N ARG K 428 O SER K 439 SHEET 4 AD2 4 SER K 403 MET K 408 -1 N PHE K 406 O CYS K 421 SHEET 1 AD3 4 PHE K 115 CYS K 124 0 SHEET 2 AD3 4 CYS K 129 LEU K 139 -1 O ARG K 130 N SER K 123 SHEET 3 AD3 4 THR K 157 PRO K 162 -1 O MET K 159 N PHE K 133 SHEET 4 AD3 4 ARG K 173 ILE K 177 -1 O SER K 176 N LEU K 158 SHEET 1 AD4 4 SER K 180 HIS K 185 0 SHEET 2 AD4 4 TRP K 190 THR K 196 -1 O LEU K 191 N CYS K 184 SHEET 3 AD4 4 VAL K 203 TYR K 208 -1 O ILE K 205 N GLY K 194 SHEET 4 AD4 4 ILE K 211 LYS K 217 -1 O THR K 213 N LEU K 206 SHEET 1 AD5 4 ALA K 232 VAL K 234 0 SHEET 2 AD5 4 SER K 237 ASP K 244 -1 O PHE K 239 N ALA K 232 SHEET 3 AD5 4 SER K 252 GLU K 259 -1 O ILE K 258 N CYS K 238 SHEET 4 AD5 4 LYS K 262 GLU K 268 -1 O VAL K 267 N ILE K 255 SHEET 1 AD6 4 GLU K 277 ASP K 284 0 SHEET 2 AD6 4 GLU K 287 ARG K 293 -1 O ARG K 293 N GLU K 277 SHEET 3 AD6 4 PRO K 302 PHE K 306 -1 O PHE K 306 N ILE K 288 SHEET 4 AD6 4 TYR K 312 TYR K 316 -1 O GLY K 315 N TRP K 303 SHEET 1 AD7 4 SER K 350 TYR K 353 0 SHEET 2 AD7 4 GLY K 356 ARG K 361 -1 O GLY K 356 N TYR K 353 SHEET 3 AD7 4 ASN K 369 ASP K 376 -1 O ILE K 374 N ILE K 359 SHEET 4 AD7 4 ILE K 389 TRP K 399 -1 O ILE K 393 N PHE K 371 SHEET 1 AD8 4 MET L 4 GLN L 6 0 SHEET 2 AD8 4 ALA L 19 SER L 25 -1 O ARG L 24 N THR L 5 SHEET 3 AD8 4 TYR L 70 ILE L 75 -1 O LEU L 73 N ILE L 21 SHEET 4 AD8 4 PHE L 62 SER L 67 -1 N SER L 65 O THR L 72 SHEET 1 AD9 6 SER L 10 VAL L 13 0 SHEET 2 AD9 6 THR L 102 ILE L 106 1 O LYS L 103 N LEU L 11 SHEET 3 AD9 6 GLY L 84 GLN L 90 -1 N GLY L 84 O VAL L 104 SHEET 4 AD9 6 LEU L 33 GLN L 38 -1 N TYR L 36 O TYR L 87 SHEET 5 AD9 6 GLN L 45 SER L 49 -1 O LEU L 47 N TRP L 35 SHEET 6 AD9 6 ASN L 53 ARG L 54 -1 O ASN L 53 N SER L 49 SHEET 1 AE1 4 SER L 10 VAL L 13 0 SHEET 2 AE1 4 THR L 102 ILE L 106 1 O LYS L 103 N LEU L 11 SHEET 3 AE1 4 GLY L 84 GLN L 90 -1 N GLY L 84 O VAL L 104 SHEET 4 AE1 4 THR L 97 PHE L 98 -1 O THR L 97 N GLN L 90 SHEET 1 AE2 4 MET M 4 GLN M 6 0 SHEET 2 AE2 4 ALA M 19 SER M 25 -1 O ARG M 24 N THR M 5 SHEET 3 AE2 4 TYR M 70 ILE M 75 -1 O ILE M 75 N ALA M 19 SHEET 4 AE2 4 PHE M 62 SER M 67 -1 N SER M 65 O THR M 72 SHEET 1 AE3 6 SER M 10 VAL M 13 0 SHEET 2 AE3 6 THR M 102 ILE M 106 1 O LYS M 103 N LEU M 11 SHEET 3 AE3 6 GLY M 84 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AE3 6 LEU M 33 GLN M 38 -1 N TYR M 36 O TYR M 87 SHEET 5 AE3 6 GLN M 45 SER M 49 -1 O GLN M 45 N LEU M 37 SHEET 6 AE3 6 ASN M 53 ARG M 54 -1 O ASN M 53 N SER M 49 SHEET 1 AE4 4 MET N 4 GLN N 6 0 SHEET 2 AE4 4 ALA N 19 SER N 25 -1 O ARG N 24 N THR N 5 SHEET 3 AE4 4 TYR N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 4 AE4 4 PHE N 62 SER N 67 -1 N SER N 65 O THR N 72 SHEET 1 AE5 6 SER N 10 VAL N 13 0 SHEET 2 AE5 6 THR N 102 ILE N 106 1 O LYS N 103 N LEU N 11 SHEET 3 AE5 6 GLY N 84 GLN N 90 -1 N GLY N 84 O VAL N 104 SHEET 4 AE5 6 LEU N 33 GLN N 38 -1 N TYR N 36 O TYR N 87 SHEET 5 AE5 6 GLN N 45 SER N 49 -1 O LEU N 47 N TRP N 35 SHEET 6 AE5 6 ASN N 53 ARG N 54 -1 O ASN N 53 N SER N 49 SHEET 1 AE6 4 SER N 10 VAL N 13 0 SHEET 2 AE6 4 THR N 102 ILE N 106 1 O LYS N 103 N LEU N 11 SHEET 3 AE6 4 GLY N 84 GLN N 90 -1 N GLY N 84 O VAL N 104 SHEET 4 AE6 4 THR N 97 PHE N 98 -1 O THR N 97 N GLN N 90 SHEET 1 AE7 4 GLN O 3 SER O 7 0 SHEET 2 AE7 4 LEU O 18 SER O 25 -1 O THR O 21 N SER O 7 SHEET 3 AE7 4 GLN O 77 LEU O 82 -1 O LEU O 80 N LEU O 20 SHEET 4 AE7 4 LEU O 67 ASP O 72 -1 N SER O 70 O TYR O 79 SHEET 1 AE8 6 LEU O 11 VAL O 12 0 SHEET 2 AE8 6 THR O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AE8 6 ALA O 88 PHE O 97 -1 N TYR O 90 O THR O 107 SHEET 4 AE8 6 TYR O 34 GLN O 39 -1 N GLN O 39 O VAL O 89 SHEET 5 AE8 6 LEU O 45 ILE O 51 -1 O ILE O 51 N TRP O 35A SHEET 6 AE8 6 THR O 57 TYR O 59 -1 O ASP O 58 N ASN O 50 SHEET 1 AE9 4 LEU O 11 VAL O 12 0 SHEET 2 AE9 4 THR O 107 VAL O 111 1 O THR O 110 N VAL O 12 SHEET 3 AE9 4 ALA O 88 PHE O 97 -1 N TYR O 90 O THR O 107 SHEET 4 AE9 4 TYR O 100F TRP O 103 -1 O LEU O 100G N GLY O 96 SHEET 1 AF1 4 MET P 4 GLN P 6 0 SHEET 2 AF1 4 ALA P 19 SER P 25 -1 O ARG P 24 N THR P 5 SHEET 3 AF1 4 TYR P 70 ILE P 75 -1 O LEU P 73 N ILE P 21 SHEET 4 AF1 4 PHE P 62 SER P 67 -1 N SER P 65 O THR P 72 SHEET 1 AF2 6 SER P 10 VAL P 13 0 SHEET 2 AF2 6 THR P 102 ILE P 106 1 O LYS P 103 N LEU P 11 SHEET 3 AF2 6 GLY P 84 GLN P 90 -1 N GLY P 84 O VAL P 104 SHEET 4 AF2 6 LEU P 33 GLN P 38 -1 N TYR P 36 O TYR P 87 SHEET 5 AF2 6 GLN P 45 SER P 49 -1 O ILE P 48 N TRP P 35 SHEET 6 AF2 6 ASN P 53 ARG P 54 -1 O ASN P 53 N SER P 49 SHEET 1 AF3 4 SER P 10 VAL P 13 0 SHEET 2 AF3 4 THR P 102 ILE P 106 1 O LYS P 103 N LEU P 11 SHEET 3 AF3 4 GLY P 84 GLN P 90 -1 N GLY P 84 O VAL P 104 SHEET 4 AF3 4 THR P 97 PHE P 98 -1 O THR P 97 N GLN P 90 SSBOND 1 CYS D 124 CYS D 129 1555 1555 2.03 SSBOND 2 CYS D 279 CYS D 292 1555 1555 2.03 SSBOND 3 CYS D 281 CYS D 290 1555 1555 2.03 SSBOND 4 CYS E 124 CYS E 129 1555 1555 2.02 SSBOND 5 CYS E 279 CYS E 292 1555 1555 2.03 SSBOND 6 CYS E 281 CYS E 290 1555 1555 2.03 SSBOND 7 CYS F 124 CYS F 129 1555 1555 2.04 SSBOND 8 CYS F 279 CYS F 292 1555 1555 2.03 SSBOND 9 CYS F 281 CYS F 290 1555 1555 2.03 SSBOND 10 CYS K 124 CYS K 129 1555 1555 2.04 SSBOND 11 CYS K 279 CYS K 292 1555 1555 2.04 SSBOND 12 CYS K 281 CYS K 290 1555 1555 2.03 LINK ND2 ASN D 88 C1 NAG D 501 1555 1555 1.44 LINK ND2 ASN D 146 C1 NAG A 1 1555 1555 1.44 LINK ND2 ASN D 235 C1 NAG D 502 1555 1555 1.44 LINK ND2 ASN E 88 C1 NAG E 501 1555 1555 1.43 LINK ND2 ASN E 146 C1 NAG B 1 1555 1555 1.43 LINK ND2 ASN E 235 C1 NAG E 502 1555 1555 1.44 LINK ND2 ASN F 88 C1 NAG F 501 1555 1555 1.45 LINK ND2 ASN F 146 C1 NAG C 1 1555 1555 1.45 LINK ND2 ASN F 235 C1 NAG F 502 1555 1555 1.45 LINK ND2 ASN K 88 C1 NAG K 501 1555 1555 1.44 LINK ND2 ASN K 146 C1 NAG G 1 1555 1555 1.45 LINK ND2 ASN K 235 C1 NAG K 502 1555 1555 1.45 LINK O4 NAG A 1 C1 NAG A 2 1555 1555 1.45 LINK O4 NAG A 2 C1 BMA A 3 1555 1555 1.46 LINK O4 NAG B 1 C1 NAG B 2 1555 1555 1.46 LINK O4 NAG B 2 C1 BMA B 3 1555 1555 1.45 LINK O4 NAG C 1 C1 NAG C 2 1555 1555 1.45 LINK O4 NAG C 2 C1 BMA C 3 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.46 LINK O4 NAG G 2 C1 BMA G 3 1555 1555 1.46 LINK O ASP D 294 CA CA D 503 1555 1555 2.25 LINK O GLY D 298 CA CA D 503 1555 1555 2.49 LINK OD2 ASP D 324 CA CA D 503 1555 1555 3.17 LINK O GLY D 342 CA CA D 503 1555 1555 2.62 LINK O ASN D 344 CA CA D 503 1555 1555 2.25 LINK OD1 ASP D 376 CA CA D 504 1555 1555 2.28 LINK OD1 ASN D 378 CA CA D 504 1555 1555 2.21 LINK OD2 ASP D 384 CA CA D 504 1555 1555 3.15 LINK O ASN D 386 CA CA D 504 1555 1555 2.65 LINK CA CA D 503 O HOH D 643 1555 1555 2.61 LINK CA CA D 504 O HOH D 606 1555 1555 2.84 LINK O ASP E 294 CA CA E 504 1555 1555 2.26 LINK O GLY E 298 CA CA E 504 1555 1555 2.67 LINK O GLY E 342 CA CA E 504 1555 1555 2.58 LINK O ASN E 344 CA CA E 504 1555 1555 2.33 LINK OD1 ASP E 376 CA CA E 503 1555 1555 2.27 LINK OD2 ASP E 376 CA CA E 503 1555 1555 3.04 LINK O ASN E 386 CA CA E 503 1555 1555 2.91 LINK CA CA E 503 O HOH E 615 1555 1555 2.66 LINK CA CA E 504 O HOH E 646 1555 1555 2.55 LINK O ASP F 294 CA CA F 503 1555 1555 2.23 LINK O GLY F 298 CA CA F 503 1555 1555 2.75 LINK O GLY F 342 CA CA F 503 1555 1555 2.73 LINK O ASN F 344 CA CA F 503 1555 1555 2.26 LINK OD1 ASP F 376 CA CA F 504 1555 1555 2.23 LINK OD1 ASN F 378 CA CA F 504 1555 1555 2.20 LINK OD2 ASP F 384 CA CA F 504 1555 1555 3.06 LINK O ASN F 386 CA CA F 504 1555 1555 2.54 LINK CA CA F 503 O HOH F 612 1555 1555 2.72 LINK CA CA F 504 O HOH F 619 1555 1555 2.65 LINK O ASP K 294 CA CA K 503 1555 1555 2.25 LINK O GLY K 298 CA CA K 503 1555 1555 2.59 LINK O GLY K 342 CA CA K 503 1555 1555 2.71 LINK O ASN K 344 CA CA K 503 1555 1555 2.26 LINK OD1 ASP K 376 CA CA K 504 1555 1555 2.29 LINK OD2 ASP K 376 CA CA K 504 1555 1555 3.09 LINK OD1 ASN K 378 CA CA K 504 1555 1555 2.35 LINK O ASN K 386 CA CA K 504 1555 1555 2.62 LINK CA CA K 503 O HOH K 641 1555 1555 2.69 CISPEP 1 ASN D 325 PRO D 326 0 1.58 CISPEP 2 ARG D 430 PRO D 431 0 4.64 CISPEP 3 LEU D 463 PRO D 464 0 -0.77 CISPEP 4 ASN E 325 PRO E 326 0 3.56 CISPEP 5 ARG E 430 PRO E 431 0 7.22 CISPEP 6 LEU E 463 PRO E 464 0 4.28 CISPEP 7 ASN F 325 PRO F 326 0 2.34 CISPEP 8 ARG F 430 PRO F 431 0 5.50 CISPEP 9 LEU F 463 PRO F 464 0 -2.77 CISPEP 10 ASN K 325 PRO K 326 0 1.92 CISPEP 11 ARG K 430 PRO K 431 0 6.03 CISPEP 12 LEU K 463 PRO K 464 0 -6.37 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000