HEADER VIRAL PROTEIN/IMMUNE SYSTEM 01-MAY-25 9OGU TITLE HIV-1 ENV BG505 SOSIP.664-DPG-HIS IN COMPLEX WITH PGT122 AND 3BNC117 TITLE 2 FABS CAVEAT 9OGU RESIDUES GLY F 568 AND THR F 569 ARE LINKED TOGETHER IN THE CAVEAT 2 9OGU MODEL; HOWEVER, THERE ARE RESIDUES BETWEEN THEM IN THE CAVEAT 3 9OGU DEPOSITED POLYMERIC SEQUENCE. RESIDUES GLY D 568 AND THR D CAVEAT 4 9OGU 569 ARE LINKED TOGETHER IN THE MODEL; HOWEVER, THERE ARE CAVEAT 5 9OGU RESIDUES BETWEEN THEM IN THE DEPOSITED POLYMERIC SEQUENCE. COMPND MOL_ID: 1; COMPND 2 MOLECULE: HIV-1 ENVELOPE GLYCOPROTEIN BG505 SOSIP.664 GP120; COMPND 3 CHAIN: A, E, C; COMPND 4 FRAGMENT: UNP RESIDUES 30-505; COMPND 5 ENGINEERED: YES; COMPND 6 MUTATION: YES; COMPND 7 MOL_ID: 2; COMPND 8 MOLECULE: ENVELOPE GLYCOPROTEIN GP160; COMPND 9 CHAIN: F, D, B; COMPND 10 SYNONYM: ENV POLYPROTEIN; COMPND 11 ENGINEERED: YES; COMPND 12 MUTATION: YES; COMPND 13 MOL_ID: 3; COMPND 14 MOLECULE: 3BNC117 FAB HEAVY CHAIN; COMPND 15 CHAIN: H, M, P; COMPND 16 ENGINEERED: YES; COMPND 17 MOL_ID: 4; COMPND 18 MOLECULE: 3BNC117 FAB LIGHT CHAIN; COMPND 19 CHAIN: I, L, Q; COMPND 20 ENGINEERED: YES; COMPND 21 MOL_ID: 5; COMPND 22 MOLECULE: PGT122 FAB HEAVY CHAIN; COMPND 23 CHAIN: J, N, R; COMPND 24 ENGINEERED: YES; COMPND 25 MOL_ID: 6; COMPND 26 MOLECULE: PGT122 FAB LIGHT CHAIN; COMPND 27 CHAIN: K, O, S; COMPND 28 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 3 ORGANISM_TAXID: 11676; SOURCE 4 GENE: ENV; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 MOL_ID: 2; SOURCE 9 ORGANISM_SCIENTIFIC: HUMAN IMMUNODEFICIENCY VIRUS 1; SOURCE 10 ORGANISM_TAXID: 11676; SOURCE 11 GENE: ENV; SOURCE 12 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 13 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 14 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 15 MOL_ID: 3; SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 17 ORGANISM_COMMON: HUMAN; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 21 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 24 ORGANISM_COMMON: HUMAN; SOURCE 25 ORGANISM_TAXID: 9606; SOURCE 26 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 27 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 28 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 29 MOL_ID: 5; SOURCE 30 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 31 ORGANISM_COMMON: HUMAN; SOURCE 32 ORGANISM_TAXID: 9606; SOURCE 33 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 34 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 35 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 36 MOL_ID: 6; SOURCE 37 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 38 ORGANISM_COMMON: HUMAN; SOURCE 39 ORGANISM_TAXID: 9606; SOURCE 40 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 41 EXPRESSION_SYSTEM_COMMON: HUMAN; SOURCE 42 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS BROADLY NEUTRALIZING ANTIBODY, GP140, VACCINE DESIGN, STABILIZING KEYWDS 2 MUTATIONS, PROTEIN DESIGN, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE KEYWDS 3 SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR T.G.ANDRADE,G.OZOROWSKI,A.B.WARD REVDAT 1 27-AUG-25 9OGU 0 JRNL AUTH D.N.CHATURBHUJ,K.SLIEPEN JRNL TITL A MODIFICATION TO HEPTAD REPEAT 1 OF GP41 IMPROVES YIELD JRNL TITL 2 AND/OR QUALITY OF SOLUBLE PRE-FUSION HIV-1 ENVELOPE JRNL TITL 3 GLYCOPROTEIN TRIMERS JRNL REF J.VIROL. 2025 JRNL REFN ESSN 1098-5514 JRNL DOI 10.1128/JVI.00913-25 REMARK 2 REMARK 2 RESOLUTION. 3.20 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX, EPU, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.200 REMARK 3 NUMBER OF PARTICLES : 210222 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9OGU COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 02-MAY-25. REMARK 100 THE DEPOSITION ID IS D_1000295538. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HIV-1 ENV BG505 SOSIP.664-DPG REMARK 245 -HIS IN COMPLEX WITH PGT122 AND REMARK 245 3BNC117 FABS REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 2.60 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS GLACIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 1800.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4500.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : 190000 REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 200 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 18-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 18-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, F, D, B, E, C, H, I, J, K, REMARK 350 AND CHAINS: M, L, N, O, P, Q, R, S, G, REMARK 350 AND CHAINS: T, U, V, W, X, Y, Z, a, b, c, REMARK 350 AND CHAINS: d, e, f, g, h, i, j, k, l, REMARK 350 AND CHAINS: m, n, o, p, q, r REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -4 REMARK 465 ASP A -3 REMARK 465 ALA A -2 REMARK 465 MET A -1 REMARK 465 LYS A 0 REMARK 465 ARG A 1 REMARK 465 GLY A 2 REMARK 465 LEU A 3 REMARK 465 CYS A 4 REMARK 465 CYS A 5 REMARK 465 VAL A 6 REMARK 465 LEU A 7 REMARK 465 LEU A 8 REMARK 465 LEU A 9 REMARK 465 CYS A 10 REMARK 465 GLY A 11 REMARK 465 ALA A 12 REMARK 465 VAL A 13 REMARK 465 PHE A 14 REMARK 465 VAL A 15 REMARK 465 SER A 16 REMARK 465 PRO A 17 REMARK 465 SER A 18 REMARK 465 GLN A 19 REMARK 465 GLU A 20 REMARK 465 ILE A 21 REMARK 465 HIS A 22 REMARK 465 ALA A 23 REMARK 465 ARG A 24 REMARK 465 PHE A 25 REMARK 465 ARG A 26 REMARK 465 ARG A 27 REMARK 465 GLY A 28 REMARK 465 ALA A 29 REMARK 465 ARG A 30 REMARK 465 ALA A 31 REMARK 465 GLU A 32 REMARK 465 ALA A 58 REMARK 465 LYS A 59 REMARK 465 ALA A 60 REMARK 465 TYR A 61 REMARK 465 GLU A 62 REMARK 465 THR A 63 REMARK 465 GLU A 64 REMARK 465 LYS A 65 REMARK 465 THR A 147 REMARK 465 ASP A 148 REMARK 465 ASP A 149 REMARK 465 ASN A 184A REMARK 465 GLU A 184B REMARK 465 ASN A 184C REMARK 465 GLN A 184D REMARK 465 GLY A 184E REMARK 465 ASN A 184F REMARK 465 ARG A 184G REMARK 465 SER A 184H REMARK 465 ASN A 184I REMARK 465 ASN A 184J REMARK 465 SER A 184K REMARK 465 ASN A 184L REMARK 465 THR A 400 REMARK 465 SER A 401 REMARK 465 VAL A 402 REMARK 465 GLN A 403 REMARK 465 GLY A 404 REMARK 465 SER A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 THR A 408 REMARK 465 GLY A 409 REMARK 465 SER A 410 REMARK 465 ARG A 504 REMARK 465 VAL A 505 REMARK 465 VAL A 506 REMARK 465 GLY A 507 REMARK 465 ARG A 508 REMARK 465 ARG A 509 REMARK 465 ARG A 510 REMARK 465 ARG A 511 REMARK 465 ARG A 512 REMARK 465 ARG A 513 REMARK 465 ALA F 512 REMARK 465 VAL F 513 REMARK 465 GLY F 514 REMARK 465 ILE F 515 REMARK 465 GLY F 516 REMARK 465 ALA F 517 REMARK 465 VAL F 518 REMARK 465 PHE F 519 REMARK 465 ILE F 549 REMARK 465 VAL F 550 REMARK 465 GLN F 551 REMARK 465 GLN F 552 REMARK 465 GLN F 553 REMARK 465 SER F 554 REMARK 465 ASN F 555 REMARK 465 LEU F 556 REMARK 465 LEU F 557 REMARK 465 ARG F 558 REMARK 465 ALA F 559 REMARK 465 PRO F 560 REMARK 465 GLU F 561 REMARK 465 ALA F 562 REMARK 465 GLN F 563 REMARK 465 GLN F 564 REMARK 465 HIS F 565 REMARK 465 LEU F 566 REMARK 465 ASP F 664 REMARK 465 GLY F 665 REMARK 465 SER F 666 REMARK 465 GLY F 667 REMARK 465 SER F 668 REMARK 465 GLY F 669 REMARK 465 GLY F 670 REMARK 465 SER F 671 REMARK 465 GLY F 672 REMARK 465 HIS F 673 REMARK 465 HIS F 674 REMARK 465 HIS F 675 REMARK 465 HIS F 676 REMARK 465 HIS F 677 REMARK 465 HIS F 678 REMARK 465 HIS F 679 REMARK 465 HIS F 680 REMARK 465 ALA D 512 REMARK 465 VAL D 513 REMARK 465 GLY D 514 REMARK 465 ILE D 515 REMARK 465 GLY D 516 REMARK 465 ALA D 517 REMARK 465 VAL D 518 REMARK 465 PHE D 519 REMARK 465 GLY D 548 REMARK 465 ILE D 549 REMARK 465 VAL D 550 REMARK 465 GLN D 551 REMARK 465 GLN D 552 REMARK 465 GLN D 553 REMARK 465 SER D 554 REMARK 465 ASN D 555 REMARK 465 LEU D 556 REMARK 465 LEU D 557 REMARK 465 ARG D 558 REMARK 465 ALA D 559 REMARK 465 PRO D 560 REMARK 465 GLU D 561 REMARK 465 ALA D 562 REMARK 465 GLN D 563 REMARK 465 GLN D 564 REMARK 465 HIS D 565 REMARK 465 LEU D 566 REMARK 465 ASP D 664 REMARK 465 GLY D 665 REMARK 465 SER D 666 REMARK 465 GLY D 667 REMARK 465 SER D 668 REMARK 465 GLY D 669 REMARK 465 GLY D 670 REMARK 465 SER D 671 REMARK 465 GLY D 672 REMARK 465 HIS D 673 REMARK 465 HIS D 674 REMARK 465 HIS D 675 REMARK 465 HIS D 676 REMARK 465 HIS D 677 REMARK 465 HIS D 678 REMARK 465 HIS D 679 REMARK 465 HIS D 680 REMARK 465 ALA B 512 REMARK 465 VAL B 513 REMARK 465 GLY B 514 REMARK 465 ILE B 515 REMARK 465 GLY B 516 REMARK 465 ALA B 517 REMARK 465 VAL B 518 REMARK 465 ILE B 549 REMARK 465 VAL B 550 REMARK 465 GLN B 551 REMARK 465 GLN B 552 REMARK 465 GLN B 553 REMARK 465 SER B 554 REMARK 465 ASN B 555 REMARK 465 LEU B 556 REMARK 465 LEU B 557 REMARK 465 ARG B 558 REMARK 465 ALA B 559 REMARK 465 PRO B 560 REMARK 465 GLU B 561 REMARK 465 ALA B 562 REMARK 465 GLN B 563 REMARK 465 GLN B 564 REMARK 465 HIS B 565 REMARK 465 LEU B 566 REMARK 465 PRO B 567 REMARK 465 GLY B 568 REMARK 465 THR B 569 REMARK 465 VAL B 570 REMARK 465 TRP B 571 REMARK 465 ASP B 664 REMARK 465 GLY B 665 REMARK 465 SER B 666 REMARK 465 GLY B 667 REMARK 465 SER B 668 REMARK 465 GLY B 669 REMARK 465 GLY B 670 REMARK 465 SER B 671 REMARK 465 GLY B 672 REMARK 465 HIS B 673 REMARK 465 HIS B 674 REMARK 465 HIS B 675 REMARK 465 HIS B 676 REMARK 465 HIS B 677 REMARK 465 HIS B 678 REMARK 465 HIS B 679 REMARK 465 HIS B 680 REMARK 465 MET E -4 REMARK 465 ASP E -3 REMARK 465 ALA E -2 REMARK 465 MET E -1 REMARK 465 LYS E 0 REMARK 465 ARG E 1 REMARK 465 GLY E 2 REMARK 465 LEU E 3 REMARK 465 CYS E 4 REMARK 465 CYS E 5 REMARK 465 VAL E 6 REMARK 465 LEU E 7 REMARK 465 LEU E 8 REMARK 465 LEU E 9 REMARK 465 CYS E 10 REMARK 465 GLY E 11 REMARK 465 ALA E 12 REMARK 465 VAL E 13 REMARK 465 PHE E 14 REMARK 465 VAL E 15 REMARK 465 SER E 16 REMARK 465 PRO E 17 REMARK 465 SER E 18 REMARK 465 GLN E 19 REMARK 465 GLU E 20 REMARK 465 ILE E 21 REMARK 465 HIS E 22 REMARK 465 ALA E 23 REMARK 465 ARG E 24 REMARK 465 PHE E 25 REMARK 465 ARG E 26 REMARK 465 ARG E 27 REMARK 465 GLY E 28 REMARK 465 ALA E 29 REMARK 465 ARG E 30 REMARK 465 ALA E 31 REMARK 465 ALA E 58 REMARK 465 LYS E 59 REMARK 465 ALA E 60 REMARK 465 TYR E 61 REMARK 465 GLU E 62 REMARK 465 THR E 63 REMARK 465 GLU E 64 REMARK 465 LYS E 65 REMARK 465 ASN E 184A REMARK 465 GLU E 184B REMARK 465 ASN E 184C REMARK 465 GLN E 184D REMARK 465 GLY E 184E REMARK 465 ASN E 184F REMARK 465 ARG E 184G REMARK 465 SER E 184H REMARK 465 ASN E 184I REMARK 465 ASN E 184J REMARK 465 SER E 184K REMARK 465 THR E 400 REMARK 465 SER E 401 REMARK 465 VAL E 402 REMARK 465 GLN E 403 REMARK 465 GLY E 404 REMARK 465 SER E 405 REMARK 465 ASN E 406 REMARK 465 SER E 407 REMARK 465 THR E 408 REMARK 465 GLY E 409 REMARK 465 SER E 410 REMARK 465 ARG E 504 REMARK 465 VAL E 505 REMARK 465 VAL E 506 REMARK 465 GLY E 507 REMARK 465 ARG E 508 REMARK 465 ARG E 509 REMARK 465 ARG E 510 REMARK 465 ARG E 511 REMARK 465 ARG E 512 REMARK 465 ARG E 513 REMARK 465 MET C -4 REMARK 465 ASP C -3 REMARK 465 ALA C -2 REMARK 465 MET C -1 REMARK 465 LYS C 0 REMARK 465 ARG C 1 REMARK 465 GLY C 2 REMARK 465 LEU C 3 REMARK 465 CYS C 4 REMARK 465 CYS C 5 REMARK 465 VAL C 6 REMARK 465 LEU C 7 REMARK 465 LEU C 8 REMARK 465 LEU C 9 REMARK 465 CYS C 10 REMARK 465 GLY C 11 REMARK 465 ALA C 12 REMARK 465 VAL C 13 REMARK 465 PHE C 14 REMARK 465 VAL C 15 REMARK 465 SER C 16 REMARK 465 PRO C 17 REMARK 465 SER C 18 REMARK 465 GLN C 19 REMARK 465 GLU C 20 REMARK 465 ILE C 21 REMARK 465 HIS C 22 REMARK 465 ALA C 23 REMARK 465 ARG C 24 REMARK 465 PHE C 25 REMARK 465 ARG C 26 REMARK 465 ARG C 27 REMARK 465 GLY C 28 REMARK 465 ALA C 29 REMARK 465 ARG C 30 REMARK 465 ALA C 31 REMARK 465 ALA C 58 REMARK 465 LYS C 59 REMARK 465 ALA C 60 REMARK 465 TYR C 61 REMARK 465 GLU C 62 REMARK 465 THR C 63 REMARK 465 GLU C 64 REMARK 465 LYS C 65 REMARK 465 THR C 147 REMARK 465 ASP C 148 REMARK 465 ASP C 149 REMARK 465 ASN C 184A REMARK 465 GLU C 184B REMARK 465 ASN C 184C REMARK 465 GLN C 184D REMARK 465 GLY C 184E REMARK 465 ASN C 184F REMARK 465 ARG C 184G REMARK 465 SER C 184H REMARK 465 ASN C 184I REMARK 465 ASN C 184J REMARK 465 SER C 184K REMARK 465 THR C 400 REMARK 465 SER C 401 REMARK 465 VAL C 402 REMARK 465 GLN C 403 REMARK 465 GLY C 404 REMARK 465 SER C 405 REMARK 465 ASN C 406 REMARK 465 SER C 407 REMARK 465 THR C 408 REMARK 465 GLY C 409 REMARK 465 SER C 410 REMARK 465 ARG C 504 REMARK 465 VAL C 505 REMARK 465 VAL C 506 REMARK 465 GLY C 507 REMARK 465 ARG C 508 REMARK 465 ARG C 509 REMARK 465 ARG C 510 REMARK 465 ARG C 511 REMARK 465 ARG C 512 REMARK 465 ARG C 513 REMARK 465 SER H 122 REMARK 465 SER H 123 REMARK 465 ALA H 124 REMARK 465 SER H 125 REMARK 465 THR H 126 REMARK 465 LYS H 127 REMARK 465 GLY H 128 REMARK 465 PRO H 129 REMARK 465 SER H 130 REMARK 465 VAL H 131 REMARK 465 PHE H 132 REMARK 465 PRO H 133 REMARK 465 LEU H 134 REMARK 465 ALA H 135 REMARK 465 PRO H 136 REMARK 465 SER H 137 REMARK 465 SER H 138 REMARK 465 LYS H 139 REMARK 465 SER H 140 REMARK 465 THR H 141 REMARK 465 SER H 142 REMARK 465 GLY H 143 REMARK 465 GLY H 144 REMARK 465 THR H 145 REMARK 465 ALA H 146 REMARK 465 ALA H 147 REMARK 465 LEU H 148 REMARK 465 GLY H 149 REMARK 465 CYS H 150 REMARK 465 LEU H 151 REMARK 465 VAL H 152 REMARK 465 LYS H 153 REMARK 465 ASP H 154 REMARK 465 TYR H 155 REMARK 465 PHE H 156 REMARK 465 PRO H 157 REMARK 465 GLU H 158 REMARK 465 PRO H 159 REMARK 465 VAL H 160 REMARK 465 THR H 161 REMARK 465 VAL H 162 REMARK 465 SER H 163 REMARK 465 TRP H 164 REMARK 465 ASN H 165 REMARK 465 SER H 166 REMARK 465 GLY H 167 REMARK 465 ALA H 168 REMARK 465 LEU H 169 REMARK 465 THR H 170 REMARK 465 SER H 171 REMARK 465 GLY H 172 REMARK 465 VAL H 173 REMARK 465 HIS H 174 REMARK 465 THR H 175 REMARK 465 PHE H 176 REMARK 465 PRO H 177 REMARK 465 ALA H 178 REMARK 465 VAL H 179 REMARK 465 LEU H 180 REMARK 465 GLN H 181 REMARK 465 SER H 182 REMARK 465 SER H 183 REMARK 465 GLY H 184 REMARK 465 LEU H 185 REMARK 465 TYR H 186 REMARK 465 SER H 187 REMARK 465 LEU H 188 REMARK 465 SER H 189 REMARK 465 SER H 190 REMARK 465 VAL H 191 REMARK 465 VAL H 192 REMARK 465 THR H 193 REMARK 465 VAL H 194 REMARK 465 PRO H 195 REMARK 465 SER H 196 REMARK 465 SER H 197 REMARK 465 SER H 198 REMARK 465 LEU H 199 REMARK 465 GLY H 200 REMARK 465 THR H 201 REMARK 465 GLN H 202 REMARK 465 THR H 203 REMARK 465 TYR H 204 REMARK 465 ILE H 205 REMARK 465 CYS H 206 REMARK 465 ASN H 207 REMARK 465 VAL H 208 REMARK 465 ASN H 209 REMARK 465 HIS H 210 REMARK 465 LYS H 211 REMARK 465 PRO H 212 REMARK 465 SER H 213 REMARK 465 ASN H 214 REMARK 465 THR H 215 REMARK 465 LYS H 216 REMARK 465 VAL H 217 REMARK 465 ASP H 218 REMARK 465 LYS H 219 REMARK 465 LYS H 220 REMARK 465 VAL H 221 REMARK 465 GLU H 222 REMARK 465 PRO H 223 REMARK 465 LYS H 224 REMARK 465 SER H 225 REMARK 465 CYS H 226 REMARK 465 LYS I 107 REMARK 465 ARG I 108 REMARK 465 THR I 109 REMARK 465 VAL I 110 REMARK 465 ALA I 111 REMARK 465 ALA I 112 REMARK 465 PRO I 113 REMARK 465 SER I 114 REMARK 465 VAL I 115 REMARK 465 PHE I 116 REMARK 465 ILE I 117 REMARK 465 PHE I 118 REMARK 465 PRO I 119 REMARK 465 PRO I 120 REMARK 465 SER I 121 REMARK 465 ASP I 122 REMARK 465 GLU I 123 REMARK 465 GLN I 124 REMARK 465 LEU I 125 REMARK 465 LYS I 126 REMARK 465 SER I 127 REMARK 465 GLY I 128 REMARK 465 THR I 129 REMARK 465 ALA I 130 REMARK 465 SER I 131 REMARK 465 VAL I 132 REMARK 465 VAL I 133 REMARK 465 CYS I 134 REMARK 465 LEU I 135 REMARK 465 LEU I 136 REMARK 465 ASN I 137 REMARK 465 ASN I 138 REMARK 465 PHE I 139 REMARK 465 TYR I 140 REMARK 465 PRO I 141 REMARK 465 ARG I 142 REMARK 465 GLU I 143 REMARK 465 ALA I 144 REMARK 465 LYS I 145 REMARK 465 VAL I 146 REMARK 465 GLN I 147 REMARK 465 TRP I 148 REMARK 465 LYS I 149 REMARK 465 VAL I 150 REMARK 465 ASP I 151 REMARK 465 ASN I 152 REMARK 465 ALA I 153 REMARK 465 LEU I 154 REMARK 465 GLN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 ASN I 158 REMARK 465 SER I 159 REMARK 465 GLN I 160 REMARK 465 GLU I 161 REMARK 465 SER I 162 REMARK 465 VAL I 163 REMARK 465 THR I 164 REMARK 465 GLU I 165 REMARK 465 GLN I 166 REMARK 465 ASP I 167 REMARK 465 SER I 168 REMARK 465 LYS I 169 REMARK 465 ASP I 170 REMARK 465 SER I 171 REMARK 465 THR I 172 REMARK 465 TYR I 173 REMARK 465 SER I 174 REMARK 465 LEU I 175 REMARK 465 SER I 176 REMARK 465 SER I 177 REMARK 465 THR I 178 REMARK 465 LEU I 179 REMARK 465 THR I 180 REMARK 465 LEU I 181 REMARK 465 SER I 182 REMARK 465 LYS I 183 REMARK 465 ALA I 184 REMARK 465 ASP I 185 REMARK 465 TYR I 186 REMARK 465 GLU I 187 REMARK 465 LYS I 188 REMARK 465 HIS I 189 REMARK 465 LYS I 190 REMARK 465 VAL I 191 REMARK 465 TYR I 192 REMARK 465 ALA I 193 REMARK 465 CYS I 194 REMARK 465 GLU I 195 REMARK 465 VAL I 196 REMARK 465 THR I 197 REMARK 465 HIS I 198 REMARK 465 GLN I 199 REMARK 465 GLY I 200 REMARK 465 LEU I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 PRO I 204 REMARK 465 VAL I 205 REMARK 465 THR I 206 REMARK 465 LYS I 207 REMARK 465 SER I 208 REMARK 465 PHE I 209 REMARK 465 ASN I 210 REMARK 465 ARG I 211 REMARK 465 GLY I 212 REMARK 465 GLU I 213 REMARK 465 CYS I 214 REMARK 465 ALA J 114 REMARK 465 SER J 115 REMARK 465 THR J 116 REMARK 465 LYS J 117 REMARK 465 GLY J 118 REMARK 465 PRO J 119 REMARK 465 SER J 120 REMARK 465 VAL J 121 REMARK 465 PHE J 122 REMARK 465 PRO J 123 REMARK 465 LEU J 124 REMARK 465 ALA J 125 REMARK 465 PRO J 126 REMARK 465 SER J 127 REMARK 465 SER J 128 REMARK 465 LYS J 129 REMARK 465 SER J 130 REMARK 465 THR J 131 REMARK 465 SER J 132 REMARK 465 GLY J 133 REMARK 465 GLY J 134 REMARK 465 THR J 135 REMARK 465 ALA J 136 REMARK 465 ALA J 137 REMARK 465 LEU J 138 REMARK 465 GLY J 139 REMARK 465 CYS J 140 REMARK 465 LEU J 141 REMARK 465 VAL J 142 REMARK 465 LYS J 143 REMARK 465 ASP J 144 REMARK 465 TYR J 145 REMARK 465 PHE J 146 REMARK 465 PRO J 147 REMARK 465 GLU J 148 REMARK 465 PRO J 149 REMARK 465 VAL J 150 REMARK 465 THR J 151 REMARK 465 VAL J 152 REMARK 465 SER J 153 REMARK 465 TRP J 154 REMARK 465 ASN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 ALA J 158 REMARK 465 LEU J 159 REMARK 465 THR J 160 REMARK 465 SER J 161 REMARK 465 GLY J 162 REMARK 465 VAL J 163 REMARK 465 HIS J 164 REMARK 465 THR J 165 REMARK 465 PHE J 166 REMARK 465 PRO J 167 REMARK 465 ALA J 168 REMARK 465 VAL J 169 REMARK 465 LEU J 170 REMARK 465 GLN J 171 REMARK 465 SER J 172 REMARK 465 SER J 173 REMARK 465 GLY J 174 REMARK 465 LEU J 175 REMARK 465 TYR J 176 REMARK 465 SER J 177 REMARK 465 LEU J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 VAL J 181 REMARK 465 VAL J 182 REMARK 465 THR J 183 REMARK 465 VAL J 184 REMARK 465 PRO J 185 REMARK 465 SER J 186 REMARK 465 SER J 187 REMARK 465 SER J 188 REMARK 465 LEU J 189 REMARK 465 GLY J 190 REMARK 465 THR J 191 REMARK 465 GLN J 192 REMARK 465 THR J 193 REMARK 465 TYR J 194 REMARK 465 ILE J 195 REMARK 465 CYS J 196 REMARK 465 ASN J 197 REMARK 465 VAL J 198 REMARK 465 ASN J 199 REMARK 465 HIS J 200 REMARK 465 LYS J 201 REMARK 465 PRO J 202 REMARK 465 SER J 203 REMARK 465 ASN J 204 REMARK 465 THR J 205 REMARK 465 LYS J 206 REMARK 465 VAL J 207 REMARK 465 ASP J 208 REMARK 465 LYS J 209 REMARK 465 ARG J 210 REMARK 465 VAL J 211 REMARK 465 GLU J 212 REMARK 465 PRO J 213 REMARK 465 LYS J 214 REMARK 465 SER J 215 REMARK 465 CYS J 216 REMARK 465 GLN K 108 REMARK 465 PRO K 109 REMARK 465 LYS K 110 REMARK 465 ALA K 111 REMARK 465 ALA K 112 REMARK 465 PRO K 113 REMARK 465 SER K 114 REMARK 465 VAL K 115 REMARK 465 THR K 116 REMARK 465 LEU K 117 REMARK 465 PHE K 118 REMARK 465 PRO K 119 REMARK 465 PRO K 120 REMARK 465 SER K 121 REMARK 465 SER K 122 REMARK 465 GLU K 123 REMARK 465 GLU K 124 REMARK 465 LEU K 125 REMARK 465 GLN K 126 REMARK 465 ALA K 127 REMARK 465 ASN K 128 REMARK 465 LYS K 129 REMARK 465 ALA K 130 REMARK 465 THR K 131 REMARK 465 LEU K 132 REMARK 465 VAL K 133 REMARK 465 CYS K 134 REMARK 465 LEU K 135 REMARK 465 ILE K 136 REMARK 465 SER K 137 REMARK 465 ASP K 138 REMARK 465 PHE K 139 REMARK 465 TYR K 140 REMARK 465 PRO K 141 REMARK 465 GLY K 142 REMARK 465 ALA K 143 REMARK 465 VAL K 144 REMARK 465 THR K 145 REMARK 465 VAL K 146 REMARK 465 ALA K 147 REMARK 465 TRP K 148 REMARK 465 LYS K 149 REMARK 465 ALA K 150 REMARK 465 ASP K 151 REMARK 465 SER K 152 REMARK 465 SER K 153 REMARK 465 PRO K 154 REMARK 465 VAL K 155 REMARK 465 LYS K 156 REMARK 465 ALA K 157 REMARK 465 GLY K 158 REMARK 465 VAL K 159 REMARK 465 GLU K 160 REMARK 465 THR K 161 REMARK 465 THR K 162 REMARK 465 THR K 163 REMARK 465 PRO K 164 REMARK 465 SER K 165 REMARK 465 LYS K 166 REMARK 465 GLN K 167 REMARK 465 SER K 168 REMARK 465 ASN K 169 REMARK 465 ASN K 170 REMARK 465 LYS K 171 REMARK 465 TYR K 172 REMARK 465 ALA K 173 REMARK 465 ALA K 174 REMARK 465 SER K 175 REMARK 465 SER K 176 REMARK 465 TYR K 177 REMARK 465 LEU K 178 REMARK 465 SER K 179 REMARK 465 LEU K 180 REMARK 465 THR K 181 REMARK 465 PRO K 182 REMARK 465 GLU K 183 REMARK 465 GLN K 184 REMARK 465 TRP K 185 REMARK 465 LYS K 186 REMARK 465 SER K 187 REMARK 465 HIS K 188 REMARK 465 LYS K 189 REMARK 465 SER K 190 REMARK 465 TYR K 191 REMARK 465 SER K 192 REMARK 465 CYS K 193 REMARK 465 GLN K 194 REMARK 465 VAL K 195 REMARK 465 THR K 196 REMARK 465 HIS K 197 REMARK 465 GLU K 198 REMARK 465 GLY K 199 REMARK 465 SER K 200 REMARK 465 THR K 201 REMARK 465 VAL K 202 REMARK 465 GLU K 203 REMARK 465 LYS K 204 REMARK 465 THR K 205 REMARK 465 VAL K 206 REMARK 465 ALA K 207 REMARK 465 PRO K 208 REMARK 465 THR K 209 REMARK 465 GLU K 210 REMARK 465 CYS K 211 REMARK 465 SER K 212 REMARK 465 SER M 122 REMARK 465 SER M 123 REMARK 465 ALA M 124 REMARK 465 SER M 125 REMARK 465 THR M 126 REMARK 465 LYS M 127 REMARK 465 GLY M 128 REMARK 465 PRO M 129 REMARK 465 SER M 130 REMARK 465 VAL M 131 REMARK 465 PHE M 132 REMARK 465 PRO M 133 REMARK 465 LEU M 134 REMARK 465 ALA M 135 REMARK 465 PRO M 136 REMARK 465 SER M 137 REMARK 465 SER M 138 REMARK 465 LYS M 139 REMARK 465 SER M 140 REMARK 465 THR M 141 REMARK 465 SER M 142 REMARK 465 GLY M 143 REMARK 465 GLY M 144 REMARK 465 THR M 145 REMARK 465 ALA M 146 REMARK 465 ALA M 147 REMARK 465 LEU M 148 REMARK 465 GLY M 149 REMARK 465 CYS M 150 REMARK 465 LEU M 151 REMARK 465 VAL M 152 REMARK 465 LYS M 153 REMARK 465 ASP M 154 REMARK 465 TYR M 155 REMARK 465 PHE M 156 REMARK 465 PRO M 157 REMARK 465 GLU M 158 REMARK 465 PRO M 159 REMARK 465 VAL M 160 REMARK 465 THR M 161 REMARK 465 VAL M 162 REMARK 465 SER M 163 REMARK 465 TRP M 164 REMARK 465 ASN M 165 REMARK 465 SER M 166 REMARK 465 GLY M 167 REMARK 465 ALA M 168 REMARK 465 LEU M 169 REMARK 465 THR M 170 REMARK 465 SER M 171 REMARK 465 GLY M 172 REMARK 465 VAL M 173 REMARK 465 HIS M 174 REMARK 465 THR M 175 REMARK 465 PHE M 176 REMARK 465 PRO M 177 REMARK 465 ALA M 178 REMARK 465 VAL M 179 REMARK 465 LEU M 180 REMARK 465 GLN M 181 REMARK 465 SER M 182 REMARK 465 SER M 183 REMARK 465 GLY M 184 REMARK 465 LEU M 185 REMARK 465 TYR M 186 REMARK 465 SER M 187 REMARK 465 LEU M 188 REMARK 465 SER M 189 REMARK 465 SER M 190 REMARK 465 VAL M 191 REMARK 465 VAL M 192 REMARK 465 THR M 193 REMARK 465 VAL M 194 REMARK 465 PRO M 195 REMARK 465 SER M 196 REMARK 465 SER M 197 REMARK 465 SER M 198 REMARK 465 LEU M 199 REMARK 465 GLY M 200 REMARK 465 THR M 201 REMARK 465 GLN M 202 REMARK 465 THR M 203 REMARK 465 TYR M 204 REMARK 465 ILE M 205 REMARK 465 CYS M 206 REMARK 465 ASN M 207 REMARK 465 VAL M 208 REMARK 465 ASN M 209 REMARK 465 HIS M 210 REMARK 465 LYS M 211 REMARK 465 PRO M 212 REMARK 465 SER M 213 REMARK 465 ASN M 214 REMARK 465 THR M 215 REMARK 465 LYS M 216 REMARK 465 VAL M 217 REMARK 465 ASP M 218 REMARK 465 LYS M 219 REMARK 465 LYS M 220 REMARK 465 VAL M 221 REMARK 465 GLU M 222 REMARK 465 PRO M 223 REMARK 465 LYS M 224 REMARK 465 SER M 225 REMARK 465 CYS M 226 REMARK 465 LYS L 107 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 VAL L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 SER L 114 REMARK 465 VAL L 115 REMARK 465 PHE L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 ASP L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 LYS L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 THR L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 LEU L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 ARG L 142 REMARK 465 GLU L 143 REMARK 465 ALA L 144 REMARK 465 LYS L 145 REMARK 465 VAL L 146 REMARK 465 GLN L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 VAL L 150 REMARK 465 ASP L 151 REMARK 465 ASN L 152 REMARK 465 ALA L 153 REMARK 465 LEU L 154 REMARK 465 GLN L 155 REMARK 465 SER L 156 REMARK 465 GLY L 157 REMARK 465 ASN L 158 REMARK 465 SER L 159 REMARK 465 GLN L 160 REMARK 465 GLU L 161 REMARK 465 SER L 162 REMARK 465 VAL L 163 REMARK 465 THR L 164 REMARK 465 GLU L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 LEU L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 SER L 182 REMARK 465 LYS L 183 REMARK 465 ALA L 184 REMARK 465 ASP L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 LYS L 188 REMARK 465 HIS L 189 REMARK 465 LYS L 190 REMARK 465 VAL L 191 REMARK 465 TYR L 192 REMARK 465 ALA L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 VAL L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 GLN L 199 REMARK 465 GLY L 200 REMARK 465 LEU L 201 REMARK 465 SER L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 VAL L 205 REMARK 465 THR L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 GLY L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 SER N 113 REMARK 465 ALA N 114 REMARK 465 SER N 115 REMARK 465 THR N 116 REMARK 465 LYS N 117 REMARK 465 GLY N 118 REMARK 465 PRO N 119 REMARK 465 SER N 120 REMARK 465 VAL N 121 REMARK 465 PHE N 122 REMARK 465 PRO N 123 REMARK 465 LEU N 124 REMARK 465 ALA N 125 REMARK 465 PRO N 126 REMARK 465 SER N 127 REMARK 465 SER N 128 REMARK 465 LYS N 129 REMARK 465 SER N 130 REMARK 465 THR N 131 REMARK 465 SER N 132 REMARK 465 GLY N 133 REMARK 465 GLY N 134 REMARK 465 THR N 135 REMARK 465 ALA N 136 REMARK 465 ALA N 137 REMARK 465 LEU N 138 REMARK 465 GLY N 139 REMARK 465 CYS N 140 REMARK 465 LEU N 141 REMARK 465 VAL N 142 REMARK 465 LYS N 143 REMARK 465 ASP N 144 REMARK 465 TYR N 145 REMARK 465 PHE N 146 REMARK 465 PRO N 147 REMARK 465 GLU N 148 REMARK 465 PRO N 149 REMARK 465 VAL N 150 REMARK 465 THR N 151 REMARK 465 VAL N 152 REMARK 465 SER N 153 REMARK 465 TRP N 154 REMARK 465 ASN N 155 REMARK 465 SER N 156 REMARK 465 GLY N 157 REMARK 465 ALA N 158 REMARK 465 LEU N 159 REMARK 465 THR N 160 REMARK 465 SER N 161 REMARK 465 GLY N 162 REMARK 465 VAL N 163 REMARK 465 HIS N 164 REMARK 465 THR N 165 REMARK 465 PHE N 166 REMARK 465 PRO N 167 REMARK 465 ALA N 168 REMARK 465 VAL N 169 REMARK 465 LEU N 170 REMARK 465 GLN N 171 REMARK 465 SER N 172 REMARK 465 SER N 173 REMARK 465 GLY N 174 REMARK 465 LEU N 175 REMARK 465 TYR N 176 REMARK 465 SER N 177 REMARK 465 LEU N 178 REMARK 465 SER N 179 REMARK 465 SER N 180 REMARK 465 VAL N 181 REMARK 465 VAL N 182 REMARK 465 THR N 183 REMARK 465 VAL N 184 REMARK 465 PRO N 185 REMARK 465 SER N 186 REMARK 465 SER N 187 REMARK 465 SER N 188 REMARK 465 LEU N 189 REMARK 465 GLY N 190 REMARK 465 THR N 191 REMARK 465 GLN N 192 REMARK 465 THR N 193 REMARK 465 TYR N 194 REMARK 465 ILE N 195 REMARK 465 CYS N 196 REMARK 465 ASN N 197 REMARK 465 VAL N 198 REMARK 465 ASN N 199 REMARK 465 HIS N 200 REMARK 465 LYS N 201 REMARK 465 PRO N 202 REMARK 465 SER N 203 REMARK 465 ASN N 204 REMARK 465 THR N 205 REMARK 465 LYS N 206 REMARK 465 VAL N 207 REMARK 465 ASP N 208 REMARK 465 LYS N 209 REMARK 465 ARG N 210 REMARK 465 VAL N 211 REMARK 465 GLU N 212 REMARK 465 PRO N 213 REMARK 465 LYS N 214 REMARK 465 SER N 215 REMARK 465 CYS N 216 REMARK 465 GLN O 108 REMARK 465 PRO O 109 REMARK 465 LYS O 110 REMARK 465 ALA O 111 REMARK 465 ALA O 112 REMARK 465 PRO O 113 REMARK 465 SER O 114 REMARK 465 VAL O 115 REMARK 465 THR O 116 REMARK 465 LEU O 117 REMARK 465 PHE O 118 REMARK 465 PRO O 119 REMARK 465 PRO O 120 REMARK 465 SER O 121 REMARK 465 SER O 122 REMARK 465 GLU O 123 REMARK 465 GLU O 124 REMARK 465 LEU O 125 REMARK 465 GLN O 126 REMARK 465 ALA O 127 REMARK 465 ASN O 128 REMARK 465 LYS O 129 REMARK 465 ALA O 130 REMARK 465 THR O 131 REMARK 465 LEU O 132 REMARK 465 VAL O 133 REMARK 465 CYS O 134 REMARK 465 LEU O 135 REMARK 465 ILE O 136 REMARK 465 SER O 137 REMARK 465 ASP O 138 REMARK 465 PHE O 139 REMARK 465 TYR O 140 REMARK 465 PRO O 141 REMARK 465 GLY O 142 REMARK 465 ALA O 143 REMARK 465 VAL O 144 REMARK 465 THR O 145 REMARK 465 VAL O 146 REMARK 465 ALA O 147 REMARK 465 TRP O 148 REMARK 465 LYS O 149 REMARK 465 ALA O 150 REMARK 465 ASP O 151 REMARK 465 SER O 152 REMARK 465 SER O 153 REMARK 465 PRO O 154 REMARK 465 VAL O 155 REMARK 465 LYS O 156 REMARK 465 ALA O 157 REMARK 465 GLY O 158 REMARK 465 VAL O 159 REMARK 465 GLU O 160 REMARK 465 THR O 161 REMARK 465 THR O 162 REMARK 465 THR O 163 REMARK 465 PRO O 164 REMARK 465 SER O 165 REMARK 465 LYS O 166 REMARK 465 GLN O 167 REMARK 465 SER O 168 REMARK 465 ASN O 169 REMARK 465 ASN O 170 REMARK 465 LYS O 171 REMARK 465 TYR O 172 REMARK 465 ALA O 173 REMARK 465 ALA O 174 REMARK 465 SER O 175 REMARK 465 SER O 176 REMARK 465 TYR O 177 REMARK 465 LEU O 178 REMARK 465 SER O 179 REMARK 465 LEU O 180 REMARK 465 THR O 181 REMARK 465 PRO O 182 REMARK 465 GLU O 183 REMARK 465 GLN O 184 REMARK 465 TRP O 185 REMARK 465 LYS O 186 REMARK 465 SER O 187 REMARK 465 HIS O 188 REMARK 465 LYS O 189 REMARK 465 SER O 190 REMARK 465 TYR O 191 REMARK 465 SER O 192 REMARK 465 CYS O 193 REMARK 465 GLN O 194 REMARK 465 VAL O 195 REMARK 465 THR O 196 REMARK 465 HIS O 197 REMARK 465 GLU O 198 REMARK 465 GLY O 199 REMARK 465 SER O 200 REMARK 465 THR O 201 REMARK 465 VAL O 202 REMARK 465 GLU O 203 REMARK 465 LYS O 204 REMARK 465 THR O 205 REMARK 465 VAL O 206 REMARK 465 ALA O 207 REMARK 465 PRO O 208 REMARK 465 THR O 209 REMARK 465 GLU O 210 REMARK 465 CYS O 211 REMARK 465 SER O 212 REMARK 465 SER P 122 REMARK 465 SER P 123 REMARK 465 ALA P 124 REMARK 465 SER P 125 REMARK 465 THR P 126 REMARK 465 LYS P 127 REMARK 465 GLY P 128 REMARK 465 PRO P 129 REMARK 465 SER P 130 REMARK 465 VAL P 131 REMARK 465 PHE P 132 REMARK 465 PRO P 133 REMARK 465 LEU P 134 REMARK 465 ALA P 135 REMARK 465 PRO P 136 REMARK 465 SER P 137 REMARK 465 SER P 138 REMARK 465 LYS P 139 REMARK 465 SER P 140 REMARK 465 THR P 141 REMARK 465 SER P 142 REMARK 465 GLY P 143 REMARK 465 GLY P 144 REMARK 465 THR P 145 REMARK 465 ALA P 146 REMARK 465 ALA P 147 REMARK 465 LEU P 148 REMARK 465 GLY P 149 REMARK 465 CYS P 150 REMARK 465 LEU P 151 REMARK 465 VAL P 152 REMARK 465 LYS P 153 REMARK 465 ASP P 154 REMARK 465 TYR P 155 REMARK 465 PHE P 156 REMARK 465 PRO P 157 REMARK 465 GLU P 158 REMARK 465 PRO P 159 REMARK 465 VAL P 160 REMARK 465 THR P 161 REMARK 465 VAL P 162 REMARK 465 SER P 163 REMARK 465 TRP P 164 REMARK 465 ASN P 165 REMARK 465 SER P 166 REMARK 465 GLY P 167 REMARK 465 ALA P 168 REMARK 465 LEU P 169 REMARK 465 THR P 170 REMARK 465 SER P 171 REMARK 465 GLY P 172 REMARK 465 VAL P 173 REMARK 465 HIS P 174 REMARK 465 THR P 175 REMARK 465 PHE P 176 REMARK 465 PRO P 177 REMARK 465 ALA P 178 REMARK 465 VAL P 179 REMARK 465 LEU P 180 REMARK 465 GLN P 181 REMARK 465 SER P 182 REMARK 465 SER P 183 REMARK 465 GLY P 184 REMARK 465 LEU P 185 REMARK 465 TYR P 186 REMARK 465 SER P 187 REMARK 465 LEU P 188 REMARK 465 SER P 189 REMARK 465 SER P 190 REMARK 465 VAL P 191 REMARK 465 VAL P 192 REMARK 465 THR P 193 REMARK 465 VAL P 194 REMARK 465 PRO P 195 REMARK 465 SER P 196 REMARK 465 SER P 197 REMARK 465 SER P 198 REMARK 465 LEU P 199 REMARK 465 GLY P 200 REMARK 465 THR P 201 REMARK 465 GLN P 202 REMARK 465 THR P 203 REMARK 465 TYR P 204 REMARK 465 ILE P 205 REMARK 465 CYS P 206 REMARK 465 ASN P 207 REMARK 465 VAL P 208 REMARK 465 ASN P 209 REMARK 465 HIS P 210 REMARK 465 LYS P 211 REMARK 465 PRO P 212 REMARK 465 SER P 213 REMARK 465 ASN P 214 REMARK 465 THR P 215 REMARK 465 LYS P 216 REMARK 465 VAL P 217 REMARK 465 ASP P 218 REMARK 465 LYS P 219 REMARK 465 LYS P 220 REMARK 465 VAL P 221 REMARK 465 GLU P 222 REMARK 465 PRO P 223 REMARK 465 LYS P 224 REMARK 465 SER P 225 REMARK 465 CYS P 226 REMARK 465 LYS Q 107 REMARK 465 ARG Q 108 REMARK 465 THR Q 109 REMARK 465 VAL Q 110 REMARK 465 ALA Q 111 REMARK 465 ALA Q 112 REMARK 465 PRO Q 113 REMARK 465 SER Q 114 REMARK 465 VAL Q 115 REMARK 465 PHE Q 116 REMARK 465 ILE Q 117 REMARK 465 PHE Q 118 REMARK 465 PRO Q 119 REMARK 465 PRO Q 120 REMARK 465 SER Q 121 REMARK 465 ASP Q 122 REMARK 465 GLU Q 123 REMARK 465 GLN Q 124 REMARK 465 LEU Q 125 REMARK 465 LYS Q 126 REMARK 465 SER Q 127 REMARK 465 GLY Q 128 REMARK 465 THR Q 129 REMARK 465 ALA Q 130 REMARK 465 SER Q 131 REMARK 465 VAL Q 132 REMARK 465 VAL Q 133 REMARK 465 CYS Q 134 REMARK 465 LEU Q 135 REMARK 465 LEU Q 136 REMARK 465 ASN Q 137 REMARK 465 ASN Q 138 REMARK 465 PHE Q 139 REMARK 465 TYR Q 140 REMARK 465 PRO Q 141 REMARK 465 ARG Q 142 REMARK 465 GLU Q 143 REMARK 465 ALA Q 144 REMARK 465 LYS Q 145 REMARK 465 VAL Q 146 REMARK 465 GLN Q 147 REMARK 465 TRP Q 148 REMARK 465 LYS Q 149 REMARK 465 VAL Q 150 REMARK 465 ASP Q 151 REMARK 465 ASN Q 152 REMARK 465 ALA Q 153 REMARK 465 LEU Q 154 REMARK 465 GLN Q 155 REMARK 465 SER Q 156 REMARK 465 GLY Q 157 REMARK 465 ASN Q 158 REMARK 465 SER Q 159 REMARK 465 GLN Q 160 REMARK 465 GLU Q 161 REMARK 465 SER Q 162 REMARK 465 VAL Q 163 REMARK 465 THR Q 164 REMARK 465 GLU Q 165 REMARK 465 GLN Q 166 REMARK 465 ASP Q 167 REMARK 465 SER Q 168 REMARK 465 LYS Q 169 REMARK 465 ASP Q 170 REMARK 465 SER Q 171 REMARK 465 THR Q 172 REMARK 465 TYR Q 173 REMARK 465 SER Q 174 REMARK 465 LEU Q 175 REMARK 465 SER Q 176 REMARK 465 SER Q 177 REMARK 465 THR Q 178 REMARK 465 LEU Q 179 REMARK 465 THR Q 180 REMARK 465 LEU Q 181 REMARK 465 SER Q 182 REMARK 465 LYS Q 183 REMARK 465 ALA Q 184 REMARK 465 ASP Q 185 REMARK 465 TYR Q 186 REMARK 465 GLU Q 187 REMARK 465 LYS Q 188 REMARK 465 HIS Q 189 REMARK 465 LYS Q 190 REMARK 465 VAL Q 191 REMARK 465 TYR Q 192 REMARK 465 ALA Q 193 REMARK 465 CYS Q 194 REMARK 465 GLU Q 195 REMARK 465 VAL Q 196 REMARK 465 THR Q 197 REMARK 465 HIS Q 198 REMARK 465 GLN Q 199 REMARK 465 GLY Q 200 REMARK 465 LEU Q 201 REMARK 465 SER Q 202 REMARK 465 SER Q 203 REMARK 465 PRO Q 204 REMARK 465 VAL Q 205 REMARK 465 THR Q 206 REMARK 465 LYS Q 207 REMARK 465 SER Q 208 REMARK 465 PHE Q 209 REMARK 465 ASN Q 210 REMARK 465 ARG Q 211 REMARK 465 GLY Q 212 REMARK 465 GLU Q 213 REMARK 465 CYS Q 214 REMARK 465 GLN R 1 REMARK 465 ALA R 114 REMARK 465 SER R 115 REMARK 465 THR R 116 REMARK 465 LYS R 117 REMARK 465 GLY R 118 REMARK 465 PRO R 119 REMARK 465 SER R 120 REMARK 465 VAL R 121 REMARK 465 PHE R 122 REMARK 465 PRO R 123 REMARK 465 LEU R 124 REMARK 465 ALA R 125 REMARK 465 PRO R 126 REMARK 465 SER R 127 REMARK 465 SER R 128 REMARK 465 LYS R 129 REMARK 465 SER R 130 REMARK 465 THR R 131 REMARK 465 SER R 132 REMARK 465 GLY R 133 REMARK 465 GLY R 134 REMARK 465 THR R 135 REMARK 465 ALA R 136 REMARK 465 ALA R 137 REMARK 465 LEU R 138 REMARK 465 GLY R 139 REMARK 465 CYS R 140 REMARK 465 LEU R 141 REMARK 465 VAL R 142 REMARK 465 LYS R 143 REMARK 465 ASP R 144 REMARK 465 TYR R 145 REMARK 465 PHE R 146 REMARK 465 PRO R 147 REMARK 465 GLU R 148 REMARK 465 PRO R 149 REMARK 465 VAL R 150 REMARK 465 THR R 151 REMARK 465 VAL R 152 REMARK 465 SER R 153 REMARK 465 TRP R 154 REMARK 465 ASN R 155 REMARK 465 SER R 156 REMARK 465 GLY R 157 REMARK 465 ALA R 158 REMARK 465 LEU R 159 REMARK 465 THR R 160 REMARK 465 SER R 161 REMARK 465 GLY R 162 REMARK 465 VAL R 163 REMARK 465 HIS R 164 REMARK 465 THR R 165 REMARK 465 PHE R 166 REMARK 465 PRO R 167 REMARK 465 ALA R 168 REMARK 465 VAL R 169 REMARK 465 LEU R 170 REMARK 465 GLN R 171 REMARK 465 SER R 172 REMARK 465 SER R 173 REMARK 465 GLY R 174 REMARK 465 LEU R 175 REMARK 465 TYR R 176 REMARK 465 SER R 177 REMARK 465 LEU R 178 REMARK 465 SER R 179 REMARK 465 SER R 180 REMARK 465 VAL R 181 REMARK 465 VAL R 182 REMARK 465 THR R 183 REMARK 465 VAL R 184 REMARK 465 PRO R 185 REMARK 465 SER R 186 REMARK 465 SER R 187 REMARK 465 SER R 188 REMARK 465 LEU R 189 REMARK 465 GLY R 190 REMARK 465 THR R 191 REMARK 465 GLN R 192 REMARK 465 THR R 193 REMARK 465 TYR R 194 REMARK 465 ILE R 195 REMARK 465 CYS R 196 REMARK 465 ASN R 197 REMARK 465 VAL R 198 REMARK 465 ASN R 199 REMARK 465 HIS R 200 REMARK 465 LYS R 201 REMARK 465 PRO R 202 REMARK 465 SER R 203 REMARK 465 ASN R 204 REMARK 465 THR R 205 REMARK 465 LYS R 206 REMARK 465 VAL R 207 REMARK 465 ASP R 208 REMARK 465 LYS R 209 REMARK 465 ARG R 210 REMARK 465 VAL R 211 REMARK 465 GLU R 212 REMARK 465 PRO R 213 REMARK 465 LYS R 214 REMARK 465 SER R 215 REMARK 465 CYS R 216 REMARK 465 SER S 107 REMARK 465 GLN S 108 REMARK 465 PRO S 109 REMARK 465 LYS S 110 REMARK 465 ALA S 111 REMARK 465 ALA S 112 REMARK 465 PRO S 113 REMARK 465 SER S 114 REMARK 465 VAL S 115 REMARK 465 THR S 116 REMARK 465 LEU S 117 REMARK 465 PHE S 118 REMARK 465 PRO S 119 REMARK 465 PRO S 120 REMARK 465 SER S 121 REMARK 465 SER S 122 REMARK 465 GLU S 123 REMARK 465 GLU S 124 REMARK 465 LEU S 125 REMARK 465 GLN S 126 REMARK 465 ALA S 127 REMARK 465 ASN S 128 REMARK 465 LYS S 129 REMARK 465 ALA S 130 REMARK 465 THR S 131 REMARK 465 LEU S 132 REMARK 465 VAL S 133 REMARK 465 CYS S 134 REMARK 465 LEU S 135 REMARK 465 ILE S 136 REMARK 465 SER S 137 REMARK 465 ASP S 138 REMARK 465 PHE S 139 REMARK 465 TYR S 140 REMARK 465 PRO S 141 REMARK 465 GLY S 142 REMARK 465 ALA S 143 REMARK 465 VAL S 144 REMARK 465 THR S 145 REMARK 465 VAL S 146 REMARK 465 ALA S 147 REMARK 465 TRP S 148 REMARK 465 LYS S 149 REMARK 465 ALA S 150 REMARK 465 ASP S 151 REMARK 465 SER S 152 REMARK 465 SER S 153 REMARK 465 PRO S 154 REMARK 465 VAL S 155 REMARK 465 LYS S 156 REMARK 465 ALA S 157 REMARK 465 GLY S 158 REMARK 465 VAL S 159 REMARK 465 GLU S 160 REMARK 465 THR S 161 REMARK 465 THR S 162 REMARK 465 THR S 163 REMARK 465 PRO S 164 REMARK 465 SER S 165 REMARK 465 LYS S 166 REMARK 465 GLN S 167 REMARK 465 SER S 168 REMARK 465 ASN S 169 REMARK 465 ASN S 170 REMARK 465 LYS S 171 REMARK 465 TYR S 172 REMARK 465 ALA S 173 REMARK 465 ALA S 174 REMARK 465 SER S 175 REMARK 465 SER S 176 REMARK 465 TYR S 177 REMARK 465 LEU S 178 REMARK 465 SER S 179 REMARK 465 LEU S 180 REMARK 465 THR S 181 REMARK 465 PRO S 182 REMARK 465 GLU S 183 REMARK 465 GLN S 184 REMARK 465 TRP S 185 REMARK 465 LYS S 186 REMARK 465 SER S 187 REMARK 465 HIS S 188 REMARK 465 LYS S 189 REMARK 465 SER S 190 REMARK 465 TYR S 191 REMARK 465 SER S 192 REMARK 465 CYS S 193 REMARK 465 GLN S 194 REMARK 465 VAL S 195 REMARK 465 THR S 196 REMARK 465 HIS S 197 REMARK 465 GLU S 198 REMARK 465 GLY S 199 REMARK 465 SER S 200 REMARK 465 THR S 201 REMARK 465 VAL S 202 REMARK 465 GLU S 203 REMARK 465 LYS S 204 REMARK 465 THR S 205 REMARK 465 VAL S 206 REMARK 465 ALA S 207 REMARK 465 PRO S 208 REMARK 465 THR S 209 REMARK 465 GLU S 210 REMARK 465 CYS S 211 REMARK 465 SER S 212 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION REMARK 500 CYS A 296 CB CYS A 296 SG -0.112 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 CYS A 247 CA - CB - SG ANGL. DEV. = 9.5 DEGREES REMARK 500 LEU A 259 CA - CB - CG ANGL. DEV. = 15.9 DEGREES REMARK 500 CYS A 445 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 LEU E 259 CA - CB - CG ANGL. DEV. = 13.9 DEGREES REMARK 500 CYS C 205 CA - CB - SG ANGL. DEV. = 6.7 DEGREES REMARK 500 CYS C 247 CA - CB - SG ANGL. DEV. = 7.7 DEGREES REMARK 500 CYS C 501 CA - CB - SG ANGL. DEV. = 15.0 DEGREES REMARK 500 ASP M 106 CB - CG - OD1 ANGL. DEV. = 6.8 DEGREES REMARK 500 LEU N 63 CA - CB - CG ANGL. DEV. = 18.6 DEGREES REMARK 500 CYS O 88 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 ASP P 109 CB - CG - OD1 ANGL. DEV. = 5.5 DEGREES REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ALA A 73 46.04 -93.04 REMARK 500 LYS A 252 78.97 55.68 REMARK 500 GLN A 258 -10.49 72.25 REMARK 500 ALA A 266 -176.87 57.79 REMARK 500 GLU A 267 -50.05 -123.28 REMARK 500 ASP A 325 68.81 61.54 REMARK 500 GLU A 340 -19.64 75.86 REMARK 500 ASN A 363 -71.27 -54.93 REMARK 500 SER A 364 142.50 -178.01 REMARK 500 SER A 463 48.40 -93.29 REMARK 500 THR A 464 -139.41 50.46 REMARK 500 MET A 475 -6.33 73.31 REMARK 500 LEU A 483 51.80 -90.67 REMARK 500 LEU F 523 19.20 59.22 REMARK 500 LEU F 545 18.58 -141.44 REMARK 500 CYS D 598 32.20 -96.68 REMARK 500 LEU B 523 17.78 59.51 REMARK 500 ASN E 136 38.41 -144.69 REMARK 500 ASN E 137 -123.61 57.23 REMARK 500 ASP E 140 -135.78 58.93 REMARK 500 ASP E 141 155.16 -42.57 REMARK 500 ASN E 234 -77.56 -68.86 REMARK 500 GLN E 258 -10.97 73.26 REMARK 500 ALA E 266 -170.61 58.62 REMARK 500 GLU E 340 -19.23 77.31 REMARK 500 MET E 475 -7.43 76.13 REMARK 500 ALA C 70 94.82 -67.68 REMARK 500 ALA C 73 52.67 -93.39 REMARK 500 ASN C 88 16.99 59.59 REMARK 500 PRO C 118 58.48 -93.10 REMARK 500 CYS C 119 -179.07 -170.49 REMARK 500 LEU C 122 57.56 -95.13 REMARK 500 ARG C 151 -103.77 53.64 REMARK 500 CYS C 157 81.35 59.94 REMARK 500 GLN C 258 -9.74 73.63 REMARK 500 ASN C 262 -137.15 50.90 REMARK 500 ALA C 266 -174.47 58.32 REMARK 500 GLU C 267 -51.25 -121.95 REMARK 500 THR C 387 30.28 -92.40 REMARK 500 SER C 393 159.52 67.87 REMARK 500 ASN C 462 46.95 39.43 REMARK 500 THR C 464 -151.59 57.62 REMARK 500 MET C 475 -2.77 73.12 REMARK 500 ARG I 39 49.91 -90.27 REMARK 500 ASP I 50 -169.71 63.71 REMARK 500 GLN I 69 -2.19 -140.23 REMARK 500 TYR I 91 -119.04 49.52 REMARK 500 LEU J 63 58.44 -95.66 REMARK 500 VAL J 100E -46.67 78.78 REMARK 500 GLN K 37 115.74 -161.68 REMARK 500 REMARK 500 THIS ENTRY HAS 78 RAMACHANDRAN OUTLIERS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG C 304 0.12 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-70476 RELATED DB: EMDB REMARK 900 HIV-1 ENV BG505 SOSIP.664-DPG-HIS IN COMPLEX WITH PGT122 AND REMARK 900 3BNC117 FABS DBREF 9OGU A 31 508 UNP Q2N0S6 Q2N0S6_9HIV1 30 505 DBREF1 9OGU F 512 664 UNP A0A6H1VYE9_9PLVG DBREF2 9OGU F A0A6H1VYE9 509 661 DBREF1 9OGU D 512 664 UNP A0A6H1VYE9_9PLVG DBREF2 9OGU D A0A6H1VYE9 509 661 DBREF1 9OGU B 512 664 UNP A0A6H1VYE9_9PLVG DBREF2 9OGU B A0A6H1VYE9 509 661 DBREF 9OGU E 31 508 UNP Q2N0S6 Q2N0S6_9HIV1 30 505 DBREF 9OGU C 31 508 UNP Q2N0S6 Q2N0S6_9HIV1 30 505 DBREF 9OGU H 1 226 PDB 9OGU 9OGU 1 226 DBREF 9OGU I 1 214 PDB 9OGU 9OGU 1 214 DBREF 9OGU J 1 216 PDB 9OGU 9OGU 1 216 DBREF 9OGU K 5 212 PDB 9OGU 9OGU 5 212 DBREF 9OGU M 1 226 PDB 9OGU 9OGU 1 226 DBREF 9OGU L 1 214 PDB 9OGU 9OGU 1 214 DBREF 9OGU N 1 216 PDB 9OGU 9OGU 1 216 DBREF 9OGU O 5 212 PDB 9OGU 9OGU 5 212 DBREF 9OGU P 1 226 PDB 9OGU 9OGU 1 226 DBREF 9OGU Q 1 214 PDB 9OGU 9OGU 1 214 DBREF 9OGU R 1 216 PDB 9OGU 9OGU 1 216 DBREF 9OGU S 5 212 PDB 9OGU 9OGU 5 212 SEQADV 9OGU MET A -4 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ASP A -3 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA A -2 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU MET A -1 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LYS A 0 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 1 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY A 2 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU A 3 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS A 4 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS A 5 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL A 6 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU A 7 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU A 8 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU A 9 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS A 10 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY A 11 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA A 12 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL A 13 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PHE A 14 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL A 15 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU SER A 16 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PRO A 17 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU SER A 18 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLN A 19 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLU A 20 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ILE A 21 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU HIS A 22 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA A 23 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 24 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PHE A 25 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 26 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 27 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY A 28 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA A 29 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 30 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ASN A 332 UNP Q2N0S6 THR 330 ENGINEERED MUTATION SEQADV 9OGU CYS A 501 UNP Q2N0S6 ALA 498 ENGINEERED MUTATION SEQADV 9OGU ARG A 509 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 510 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 511 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG A 513 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PRO F 560 UNP A0A6H1VYE ILE 556 CONFLICT SEQADV 9OGU F UNP A0A6H1VYE LEU 562 DELETION SEQADV 9OGU PRO F 567 UNP A0A6H1VYE LYS 564 ENGINEERED MUTATION SEQADV 9OGU GLY F 568 UNP A0A6H1VYE LEU 565 ENGINEERED MUTATION SEQADV 9OGU CYS F 605 UNP A0A6H1VYE THR 602 CONFLICT SEQADV 9OGU GLY F 665 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER F 666 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY F 667 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER F 668 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY F 669 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY F 670 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER F 671 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY F 672 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 673 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 674 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 675 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 676 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 677 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 678 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 679 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS F 680 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU PRO D 560 UNP A0A6H1VYE ILE 556 CONFLICT SEQADV 9OGU D UNP A0A6H1VYE LEU 562 DELETION SEQADV 9OGU PRO D 567 UNP A0A6H1VYE LYS 564 ENGINEERED MUTATION SEQADV 9OGU GLY D 568 UNP A0A6H1VYE LEU 565 ENGINEERED MUTATION SEQADV 9OGU CYS D 605 UNP A0A6H1VYE THR 602 CONFLICT SEQADV 9OGU GLY D 665 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER D 666 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY D 667 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER D 668 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY D 669 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY D 670 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER D 671 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY D 672 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 673 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 674 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 675 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 676 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 677 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 678 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 679 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS D 680 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU PRO B 560 UNP A0A6H1VYE ILE 556 CONFLICT SEQADV 9OGU B UNP A0A6H1VYE LEU 562 DELETION SEQADV 9OGU PRO B 567 UNP A0A6H1VYE LYS 564 ENGINEERED MUTATION SEQADV 9OGU GLY B 568 UNP A0A6H1VYE LEU 565 ENGINEERED MUTATION SEQADV 9OGU CYS B 605 UNP A0A6H1VYE THR 602 CONFLICT SEQADV 9OGU GLY B 665 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER B 666 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY B 667 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER B 668 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY B 669 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY B 670 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU SER B 671 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU GLY B 672 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 673 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 674 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 675 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 676 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 677 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 678 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 679 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU HIS B 680 UNP A0A6H1VYE EXPRESSION TAG SEQADV 9OGU MET E -4 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ASP E -3 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA E -2 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU MET E -1 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LYS E 0 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 1 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY E 2 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU E 3 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS E 4 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS E 5 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL E 6 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU E 7 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU E 8 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU E 9 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS E 10 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY E 11 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA E 12 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL E 13 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PHE E 14 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL E 15 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU SER E 16 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PRO E 17 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU SER E 18 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLN E 19 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLU E 20 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ILE E 21 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU HIS E 22 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA E 23 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 24 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PHE E 25 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 26 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 27 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY E 28 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA E 29 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 30 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ASN E 332 UNP Q2N0S6 THR 330 ENGINEERED MUTATION SEQADV 9OGU CYS E 501 UNP Q2N0S6 ALA 498 ENGINEERED MUTATION SEQADV 9OGU ARG E 509 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 510 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 511 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG E 513 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU MET C -4 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ASP C -3 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA C -2 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU MET C -1 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LYS C 0 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 1 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY C 2 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU C 3 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS C 4 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS C 5 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL C 6 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU C 7 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU C 8 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU LEU C 9 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU CYS C 10 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY C 11 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA C 12 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL C 13 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PHE C 14 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU VAL C 15 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU SER C 16 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PRO C 17 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU SER C 18 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLN C 19 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLU C 20 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ILE C 21 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU HIS C 22 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA C 23 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 24 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU PHE C 25 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 26 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 27 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU GLY C 28 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ALA C 29 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 30 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ASN C 332 UNP Q2N0S6 THR 330 ENGINEERED MUTATION SEQADV 9OGU CYS C 501 UNP Q2N0S6 ALA 498 ENGINEERED MUTATION SEQADV 9OGU ARG C 509 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 510 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 511 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 512 UNP Q2N0S6 EXPRESSION TAG SEQADV 9OGU ARG C 513 UNP Q2N0S6 EXPRESSION TAG SEQRES 1 A 516 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 A 516 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 A 516 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU ASN LEU SEQRES 4 A 516 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS ASP SEQRES 5 A 516 ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA LYS ALA SEQRES 6 A 516 TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR HIS ALA SEQRES 7 A 516 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE HIS LEU SEQRES 8 A 516 GLU ASN VAL THR GLU GLU PHE ASN MET TRP LYS ASN ASN SEQRES 9 A 516 MET VAL GLU GLN MET HIS THR ASP ILE ILE SER LEU TRP SEQRES 10 A 516 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 A 516 CYS VAL THR LEU GLN CYS THR ASN VAL THR ASN ASN ILE SEQRES 12 A 516 THR ASP ASP MET ARG GLY GLU LEU LYS ASN CYS SER PHE SEQRES 13 A 516 ASN MET THR THR GLU LEU ARG ASP LYS LYS GLN LYS VAL SEQRES 14 A 516 TYR SER LEU PHE TYR ARG LEU ASP VAL VAL GLN ILE ASN SEQRES 15 A 516 GLU ASN GLN GLY ASN ARG SER ASN ASN SER ASN LYS GLU SEQRES 16 A 516 TYR ARG LEU ILE ASN CYS ASN THR SER ALA ILE THR GLN SEQRES 17 A 516 ALA CYS PRO LYS VAL SER PHE GLU PRO ILE PRO ILE HIS SEQRES 18 A 516 TYR CYS ALA PRO ALA GLY PHE ALA ILE LEU LYS CYS LYS SEQRES 19 A 516 ASP LYS LYS PHE ASN GLY THR GLY PRO CYS PRO SER VAL SEQRES 20 A 516 SER THR VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SEQRES 21 A 516 SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU SEQRES 22 A 516 GLU VAL MET ILE ARG SER GLU ASN ILE THR ASN ASN ALA SEQRES 23 A 516 LYS ASN ILE LEU VAL GLN PHE ASN THR PRO VAL GLN ILE SEQRES 24 A 516 ASN CYS THR ARG PRO ASN ASN ASN THR ARG LYS SER ILE SEQRES 25 A 516 ARG ILE GLY PRO GLY GLN ALA PHE TYR ALA THR GLY ASP SEQRES 26 A 516 ILE ILE GLY ASP ILE ARG GLN ALA HIS CYS ASN VAL SER SEQRES 27 A 516 LYS ALA THR TRP ASN GLU THR LEU GLY LYS VAL VAL LYS SEQRES 28 A 516 GLN LEU ARG LYS HIS PHE GLY ASN ASN THR ILE ILE ARG SEQRES 29 A 516 PHE ALA ASN SER SER GLY GLY ASP LEU GLU VAL THR THR SEQRES 30 A 516 HIS SER PHE ASN CYS GLY GLY GLU PHE PHE TYR CYS ASN SEQRES 31 A 516 THR SER GLY LEU PHE ASN SER THR TRP ILE SER ASN THR SEQRES 32 A 516 SER VAL GLN GLY SER ASN SER THR GLY SER ASN ASP SER SEQRES 33 A 516 ILE THR LEU PRO CYS ARG ILE LYS GLN ILE ILE ASN MET SEQRES 34 A 516 TRP GLN ARG ILE GLY GLN ALA MET TYR ALA PRO PRO ILE SEQRES 35 A 516 GLN GLY VAL ILE ARG CYS VAL SER ASN ILE THR GLY LEU SEQRES 36 A 516 ILE LEU THR ARG ASP GLY GLY SER THR ASN SER THR THR SEQRES 37 A 516 GLU THR PHE ARG PRO GLY GLY GLY ASP MET ARG ASP ASN SEQRES 38 A 516 TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL LYS ILE SEQRES 39 A 516 GLU PRO LEU GLY VAL ALA PRO THR ARG CYS LYS ARG ARG SEQRES 40 A 516 VAL VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 F 168 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 F 168 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 F 168 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 F 168 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 F 168 HIS LEU PRO GLY THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 6 F 168 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 7 F 168 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 8 F 168 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 9 F 168 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 10 F 168 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 11 F 168 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 12 F 168 ASN GLU GLN ASP LEU LEU ALA LEU ASP GLY SER GLY SER SEQRES 13 F 168 GLY GLY SER GLY HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 D 168 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 D 168 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 D 168 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 D 168 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 D 168 HIS LEU PRO GLY THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 6 D 168 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 7 D 168 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 8 D 168 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 9 D 168 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 10 D 168 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 11 D 168 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 12 D 168 ASN GLU GLN ASP LEU LEU ALA LEU ASP GLY SER GLY SER SEQRES 13 D 168 GLY GLY SER GLY HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 B 168 ALA VAL GLY ILE GLY ALA VAL PHE LEU GLY PHE LEU GLY SEQRES 2 B 168 ALA ALA GLY SER THR MET GLY ALA ALA SER MET THR LEU SEQRES 3 B 168 THR VAL GLN ALA ARG ASN LEU LEU SER GLY ILE VAL GLN SEQRES 4 B 168 GLN GLN SER ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 B 168 HIS LEU PRO GLY THR VAL TRP GLY ILE LYS GLN LEU GLN SEQRES 6 B 168 ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP GLN SEQRES 7 B 168 GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU ILE SEQRES 8 B 168 CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER ASN SEQRES 9 B 168 ARG ASN LEU SER GLU ILE TRP ASP ASN MET THR TRP LEU SEQRES 10 B 168 GLN TRP ASP LYS GLU ILE SER ASN TYR THR GLN ILE ILE SEQRES 11 B 168 TYR GLY LEU LEU GLU GLU SER GLN ASN GLN GLN GLU LYS SEQRES 12 B 168 ASN GLU GLN ASP LEU LEU ALA LEU ASP GLY SER GLY SER SEQRES 13 B 168 GLY GLY SER GLY HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 E 516 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 E 516 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 E 516 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU ASN LEU SEQRES 4 E 516 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS ASP SEQRES 5 E 516 ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA LYS ALA SEQRES 6 E 516 TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR HIS ALA SEQRES 7 E 516 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE HIS LEU SEQRES 8 E 516 GLU ASN VAL THR GLU GLU PHE ASN MET TRP LYS ASN ASN SEQRES 9 E 516 MET VAL GLU GLN MET HIS THR ASP ILE ILE SER LEU TRP SEQRES 10 E 516 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 E 516 CYS VAL THR LEU GLN CYS THR ASN VAL THR ASN ASN ILE SEQRES 12 E 516 THR ASP ASP MET ARG GLY GLU LEU LYS ASN CYS SER PHE SEQRES 13 E 516 ASN MET THR THR GLU LEU ARG ASP LYS LYS GLN LYS VAL SEQRES 14 E 516 TYR SER LEU PHE TYR ARG LEU ASP VAL VAL GLN ILE ASN SEQRES 15 E 516 GLU ASN GLN GLY ASN ARG SER ASN ASN SER ASN LYS GLU SEQRES 16 E 516 TYR ARG LEU ILE ASN CYS ASN THR SER ALA ILE THR GLN SEQRES 17 E 516 ALA CYS PRO LYS VAL SER PHE GLU PRO ILE PRO ILE HIS SEQRES 18 E 516 TYR CYS ALA PRO ALA GLY PHE ALA ILE LEU LYS CYS LYS SEQRES 19 E 516 ASP LYS LYS PHE ASN GLY THR GLY PRO CYS PRO SER VAL SEQRES 20 E 516 SER THR VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SEQRES 21 E 516 SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU SEQRES 22 E 516 GLU VAL MET ILE ARG SER GLU ASN ILE THR ASN ASN ALA SEQRES 23 E 516 LYS ASN ILE LEU VAL GLN PHE ASN THR PRO VAL GLN ILE SEQRES 24 E 516 ASN CYS THR ARG PRO ASN ASN ASN THR ARG LYS SER ILE SEQRES 25 E 516 ARG ILE GLY PRO GLY GLN ALA PHE TYR ALA THR GLY ASP SEQRES 26 E 516 ILE ILE GLY ASP ILE ARG GLN ALA HIS CYS ASN VAL SER SEQRES 27 E 516 LYS ALA THR TRP ASN GLU THR LEU GLY LYS VAL VAL LYS SEQRES 28 E 516 GLN LEU ARG LYS HIS PHE GLY ASN ASN THR ILE ILE ARG SEQRES 29 E 516 PHE ALA ASN SER SER GLY GLY ASP LEU GLU VAL THR THR SEQRES 30 E 516 HIS SER PHE ASN CYS GLY GLY GLU PHE PHE TYR CYS ASN SEQRES 31 E 516 THR SER GLY LEU PHE ASN SER THR TRP ILE SER ASN THR SEQRES 32 E 516 SER VAL GLN GLY SER ASN SER THR GLY SER ASN ASP SER SEQRES 33 E 516 ILE THR LEU PRO CYS ARG ILE LYS GLN ILE ILE ASN MET SEQRES 34 E 516 TRP GLN ARG ILE GLY GLN ALA MET TYR ALA PRO PRO ILE SEQRES 35 E 516 GLN GLY VAL ILE ARG CYS VAL SER ASN ILE THR GLY LEU SEQRES 36 E 516 ILE LEU THR ARG ASP GLY GLY SER THR ASN SER THR THR SEQRES 37 E 516 GLU THR PHE ARG PRO GLY GLY GLY ASP MET ARG ASP ASN SEQRES 38 E 516 TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL LYS ILE SEQRES 39 E 516 GLU PRO LEU GLY VAL ALA PRO THR ARG CYS LYS ARG ARG SEQRES 40 E 516 VAL VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 C 516 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 C 516 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 C 516 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU ASN LEU SEQRES 4 C 516 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP LYS ASP SEQRES 5 C 516 ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA LYS ALA SEQRES 6 C 516 TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR HIS ALA SEQRES 7 C 516 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE HIS LEU SEQRES 8 C 516 GLU ASN VAL THR GLU GLU PHE ASN MET TRP LYS ASN ASN SEQRES 9 C 516 MET VAL GLU GLN MET HIS THR ASP ILE ILE SER LEU TRP SEQRES 10 C 516 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 C 516 CYS VAL THR LEU GLN CYS THR ASN VAL THR ASN ASN ILE SEQRES 12 C 516 THR ASP ASP MET ARG GLY GLU LEU LYS ASN CYS SER PHE SEQRES 13 C 516 ASN MET THR THR GLU LEU ARG ASP LYS LYS GLN LYS VAL SEQRES 14 C 516 TYR SER LEU PHE TYR ARG LEU ASP VAL VAL GLN ILE ASN SEQRES 15 C 516 GLU ASN GLN GLY ASN ARG SER ASN ASN SER ASN LYS GLU SEQRES 16 C 516 TYR ARG LEU ILE ASN CYS ASN THR SER ALA ILE THR GLN SEQRES 17 C 516 ALA CYS PRO LYS VAL SER PHE GLU PRO ILE PRO ILE HIS SEQRES 18 C 516 TYR CYS ALA PRO ALA GLY PHE ALA ILE LEU LYS CYS LYS SEQRES 19 C 516 ASP LYS LYS PHE ASN GLY THR GLY PRO CYS PRO SER VAL SEQRES 20 C 516 SER THR VAL GLN CYS THR HIS GLY ILE LYS PRO VAL VAL SEQRES 21 C 516 SER THR GLN LEU LEU LEU ASN GLY SER LEU ALA GLU GLU SEQRES 22 C 516 GLU VAL MET ILE ARG SER GLU ASN ILE THR ASN ASN ALA SEQRES 23 C 516 LYS ASN ILE LEU VAL GLN PHE ASN THR PRO VAL GLN ILE SEQRES 24 C 516 ASN CYS THR ARG PRO ASN ASN ASN THR ARG LYS SER ILE SEQRES 25 C 516 ARG ILE GLY PRO GLY GLN ALA PHE TYR ALA THR GLY ASP SEQRES 26 C 516 ILE ILE GLY ASP ILE ARG GLN ALA HIS CYS ASN VAL SER SEQRES 27 C 516 LYS ALA THR TRP ASN GLU THR LEU GLY LYS VAL VAL LYS SEQRES 28 C 516 GLN LEU ARG LYS HIS PHE GLY ASN ASN THR ILE ILE ARG SEQRES 29 C 516 PHE ALA ASN SER SER GLY GLY ASP LEU GLU VAL THR THR SEQRES 30 C 516 HIS SER PHE ASN CYS GLY GLY GLU PHE PHE TYR CYS ASN SEQRES 31 C 516 THR SER GLY LEU PHE ASN SER THR TRP ILE SER ASN THR SEQRES 32 C 516 SER VAL GLN GLY SER ASN SER THR GLY SER ASN ASP SER SEQRES 33 C 516 ILE THR LEU PRO CYS ARG ILE LYS GLN ILE ILE ASN MET SEQRES 34 C 516 TRP GLN ARG ILE GLY GLN ALA MET TYR ALA PRO PRO ILE SEQRES 35 C 516 GLN GLY VAL ILE ARG CYS VAL SER ASN ILE THR GLY LEU SEQRES 36 C 516 ILE LEU THR ARG ASP GLY GLY SER THR ASN SER THR THR SEQRES 37 C 516 GLU THR PHE ARG PRO GLY GLY GLY ASP MET ARG ASP ASN SEQRES 38 C 516 TRP ARG SER GLU LEU TYR LYS TYR LYS VAL VAL LYS ILE SEQRES 39 C 516 GLU PRO LEU GLY VAL ALA PRO THR ARG CYS LYS ARG ARG SEQRES 40 C 516 VAL VAL GLY ARG ARG ARG ARG ARG ARG SEQRES 1 H 226 GLN VAL GLN LEU LEU GLN SER GLY ALA ALA VAL THR LYS SEQRES 2 H 226 PRO GLY ALA SER VAL ARG VAL SER CYS GLU ALA SER GLY SEQRES 3 H 226 TYR ASN ILE ARG ASP TYR PHE ILE HIS TRP TRP ARG GLN SEQRES 4 H 226 ALA PRO GLY GLN GLY LEU GLN TRP VAL GLY TRP ILE ASN SEQRES 5 H 226 PRO LYS THR GLY GLN PRO ASN ASN PRO ARG GLN PHE GLN SEQRES 6 H 226 GLY ARG VAL SER LEU THR ARG HIS ALA SER TRP ASP PHE SEQRES 7 H 226 ASP THR TYR SER PHE TYR MET ASP LEU LYS ALA LEU ARG SEQRES 8 H 226 SER ASP ASP THR ALA VAL TYR PHE CYS ALA ARG GLN ARG SEQRES 9 H 226 SER ASP TYR TRP ASP PHE ASP VAL TRP GLY SER GLY THR SEQRES 10 H 226 GLN VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 H 226 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 H 226 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 H 226 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 H 226 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 H 226 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 H 226 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 H 226 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 18 H 226 GLU PRO LYS SER CYS SEQRES 1 I 206 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 I 206 SER VAL GLY ASP THR VAL THR ILE THR CYS GLN ALA ASN SEQRES 3 I 206 GLY TYR LEU ASN TRP TYR GLN GLN ARG ARG GLY LYS ALA SEQRES 4 I 206 PRO LYS LEU LEU ILE TYR ASP GLY SER LYS LEU GLU ARG SEQRES 5 I 206 GLY VAL PRO SER ARG PHE SER GLY ARG ARG TRP GLY GLN SEQRES 6 I 206 GLU TYR ASN LEU THR ILE ASN ASN LEU GLN PRO GLU ASP SEQRES 7 I 206 ILE ALA THR TYR PHE CYS GLN VAL TYR GLU PHE VAL VAL SEQRES 8 I 206 PRO GLY THR ARG LEU ASP LEU LYS ARG THR VAL ALA ALA SEQRES 9 I 206 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 10 I 206 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 11 I 206 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 12 I 206 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 13 I 206 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 14 I 206 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 15 I 206 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 16 I 206 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 J 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 J 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 J 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 J 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 J 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 J 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 J 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 J 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 J 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 J 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 J 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 J 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 J 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 J 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 J 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 J 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 J 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 J 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 J 235 CYS SEQRES 1 K 211 THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA ARG ILE SEQRES 2 K 211 THR CYS GLY GLU GLU SER LEU GLY SER ARG SER VAL ILE SEQRES 3 K 211 TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER LEU ILE SEQRES 4 K 211 ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE PRO ASP SEQRES 5 K 211 ARG PHE SER GLY SER PRO GLY SER THR PHE GLY THR THR SEQRES 6 K 211 ALA THR LEU THR ILE THR SER VAL GLU ALA GLY ASP GLU SEQRES 7 K 211 ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG ARG PRO SEQRES 8 K 211 THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU ILE VAL SEQRES 9 K 211 LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR LEU PHE SEQRES 10 K 211 PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS ALA THR SEQRES 11 K 211 LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY ALA VAL SEQRES 12 K 211 THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL LYS ALA SEQRES 13 K 211 GLY VAL GLU THR THR THR PRO SER LYS GLN SER ASN ASN SEQRES 14 K 211 LYS TYR ALA ALA SER SER TYR LEU SER LEU THR PRO GLU SEQRES 15 K 211 GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN VAL THR SEQRES 16 K 211 HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA PRO THR SEQRES 17 K 211 GLU CYS SER SEQRES 1 M 226 GLN VAL GLN LEU LEU GLN SER GLY ALA ALA VAL THR LYS SEQRES 2 M 226 PRO GLY ALA SER VAL ARG VAL SER CYS GLU ALA SER GLY SEQRES 3 M 226 TYR ASN ILE ARG ASP TYR PHE ILE HIS TRP TRP ARG GLN SEQRES 4 M 226 ALA PRO GLY GLN GLY LEU GLN TRP VAL GLY TRP ILE ASN SEQRES 5 M 226 PRO LYS THR GLY GLN PRO ASN ASN PRO ARG GLN PHE GLN SEQRES 6 M 226 GLY ARG VAL SER LEU THR ARG HIS ALA SER TRP ASP PHE SEQRES 7 M 226 ASP THR TYR SER PHE TYR MET ASP LEU LYS ALA LEU ARG SEQRES 8 M 226 SER ASP ASP THR ALA VAL TYR PHE CYS ALA ARG GLN ARG SEQRES 9 M 226 SER ASP TYR TRP ASP PHE ASP VAL TRP GLY SER GLY THR SEQRES 10 M 226 GLN VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 M 226 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 M 226 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 M 226 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 M 226 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 M 226 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 M 226 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 M 226 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 18 M 226 GLU PRO LYS SER CYS SEQRES 1 L 206 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 206 SER VAL GLY ASP THR VAL THR ILE THR CYS GLN ALA ASN SEQRES 3 L 206 GLY TYR LEU ASN TRP TYR GLN GLN ARG ARG GLY LYS ALA SEQRES 4 L 206 PRO LYS LEU LEU ILE TYR ASP GLY SER LYS LEU GLU ARG SEQRES 5 L 206 GLY VAL PRO SER ARG PHE SER GLY ARG ARG TRP GLY GLN SEQRES 6 L 206 GLU TYR ASN LEU THR ILE ASN ASN LEU GLN PRO GLU ASP SEQRES 7 L 206 ILE ALA THR TYR PHE CYS GLN VAL TYR GLU PHE VAL VAL SEQRES 8 L 206 PRO GLY THR ARG LEU ASP LEU LYS ARG THR VAL ALA ALA SEQRES 9 L 206 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 10 L 206 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 11 L 206 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 12 L 206 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 13 L 206 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 14 L 206 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 15 L 206 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 16 L 206 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 N 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 N 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 N 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 N 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 N 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 N 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 N 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 N 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 N 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 N 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 N 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 N 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 N 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 N 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 N 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 N 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 N 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 N 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 N 235 CYS SEQRES 1 O 211 THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA ARG ILE SEQRES 2 O 211 THR CYS GLY GLU GLU SER LEU GLY SER ARG SER VAL ILE SEQRES 3 O 211 TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER LEU ILE SEQRES 4 O 211 ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE PRO ASP SEQRES 5 O 211 ARG PHE SER GLY SER PRO GLY SER THR PHE GLY THR THR SEQRES 6 O 211 ALA THR LEU THR ILE THR SER VAL GLU ALA GLY ASP GLU SEQRES 7 O 211 ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG ARG PRO SEQRES 8 O 211 THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU ILE VAL SEQRES 9 O 211 LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR LEU PHE SEQRES 10 O 211 PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS ALA THR SEQRES 11 O 211 LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY ALA VAL SEQRES 12 O 211 THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL LYS ALA SEQRES 13 O 211 GLY VAL GLU THR THR THR PRO SER LYS GLN SER ASN ASN SEQRES 14 O 211 LYS TYR ALA ALA SER SER TYR LEU SER LEU THR PRO GLU SEQRES 15 O 211 GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN VAL THR SEQRES 16 O 211 HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA PRO THR SEQRES 17 O 211 GLU CYS SER SEQRES 1 P 226 GLN VAL GLN LEU LEU GLN SER GLY ALA ALA VAL THR LYS SEQRES 2 P 226 PRO GLY ALA SER VAL ARG VAL SER CYS GLU ALA SER GLY SEQRES 3 P 226 TYR ASN ILE ARG ASP TYR PHE ILE HIS TRP TRP ARG GLN SEQRES 4 P 226 ALA PRO GLY GLN GLY LEU GLN TRP VAL GLY TRP ILE ASN SEQRES 5 P 226 PRO LYS THR GLY GLN PRO ASN ASN PRO ARG GLN PHE GLN SEQRES 6 P 226 GLY ARG VAL SER LEU THR ARG HIS ALA SER TRP ASP PHE SEQRES 7 P 226 ASP THR TYR SER PHE TYR MET ASP LEU LYS ALA LEU ARG SEQRES 8 P 226 SER ASP ASP THR ALA VAL TYR PHE CYS ALA ARG GLN ARG SEQRES 9 P 226 SER ASP TYR TRP ASP PHE ASP VAL TRP GLY SER GLY THR SEQRES 10 P 226 GLN VAL THR VAL SER SER ALA SER THR LYS GLY PRO SER SEQRES 11 P 226 VAL PHE PRO LEU ALA PRO SER SER LYS SER THR SER GLY SEQRES 12 P 226 GLY THR ALA ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE SEQRES 13 P 226 PRO GLU PRO VAL THR VAL SER TRP ASN SER GLY ALA LEU SEQRES 14 P 226 THR SER GLY VAL HIS THR PHE PRO ALA VAL LEU GLN SER SEQRES 15 P 226 SER GLY LEU TYR SER LEU SER SER VAL VAL THR VAL PRO SEQRES 16 P 226 SER SER SER LEU GLY THR GLN THR TYR ILE CYS ASN VAL SEQRES 17 P 226 ASN HIS LYS PRO SER ASN THR LYS VAL ASP LYS LYS VAL SEQRES 18 P 226 GLU PRO LYS SER CYS SEQRES 1 Q 206 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 Q 206 SER VAL GLY ASP THR VAL THR ILE THR CYS GLN ALA ASN SEQRES 3 Q 206 GLY TYR LEU ASN TRP TYR GLN GLN ARG ARG GLY LYS ALA SEQRES 4 Q 206 PRO LYS LEU LEU ILE TYR ASP GLY SER LYS LEU GLU ARG SEQRES 5 Q 206 GLY VAL PRO SER ARG PHE SER GLY ARG ARG TRP GLY GLN SEQRES 6 Q 206 GLU TYR ASN LEU THR ILE ASN ASN LEU GLN PRO GLU ASP SEQRES 7 Q 206 ILE ALA THR TYR PHE CYS GLN VAL TYR GLU PHE VAL VAL SEQRES 8 Q 206 PRO GLY THR ARG LEU ASP LEU LYS ARG THR VAL ALA ALA SEQRES 9 Q 206 PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN LEU SEQRES 10 Q 206 LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN ASN SEQRES 11 Q 206 PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP SEQRES 12 Q 206 ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL THR SEQRES 13 Q 206 GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER SER SEQRES 14 Q 206 THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS LYS SEQRES 15 Q 206 VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER SER SEQRES 16 Q 206 PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS SEQRES 1 R 235 GLN VAL HIS LEU GLN GLU SER GLY PRO GLY LEU VAL LYS SEQRES 2 R 235 PRO SER GLU THR LEU SER LEU THR CYS ASN VAL SER GLY SEQRES 3 R 235 THR LEU VAL ARG ASP ASN TYR TRP SER TRP ILE ARG GLN SEQRES 4 R 235 PRO LEU GLY LYS GLN PRO GLU TRP ILE GLY TYR VAL HIS SEQRES 5 R 235 ASP SER GLY ASP THR ASN TYR ASN PRO SER LEU LYS SER SEQRES 6 R 235 ARG VAL HIS LEU SER LEU ASP LYS SER LYS ASN LEU VAL SEQRES 7 R 235 SER LEU ARG LEU THR GLY VAL THR ALA ALA ASP SER ALA SEQRES 8 R 235 ILE TYR TYR CYS ALA THR THR LYS HIS GLY ARG ARG ILE SEQRES 9 R 235 TYR GLY VAL VAL ALA PHE LYS GLU TRP PHE THR TYR PHE SEQRES 10 R 235 TYR MET ASP VAL TRP GLY LYS GLY THR SER VAL THR VAL SEQRES 11 R 235 SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO LEU SEQRES 12 R 235 ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA ALA SEQRES 13 R 235 LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL SEQRES 14 R 235 THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY VAL SEQRES 15 R 235 HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU TYR SEQRES 16 R 235 SER LEU SER SER VAL VAL THR VAL PRO SER SER SER LEU SEQRES 17 R 235 GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SEQRES 18 R 235 SER ASN THR LYS VAL ASP LYS ARG VAL GLU PRO LYS SER SEQRES 19 R 235 CYS SEQRES 1 S 211 THR PHE VAL SER VAL ALA PRO GLY GLN THR ALA ARG ILE SEQRES 2 S 211 THR CYS GLY GLU GLU SER LEU GLY SER ARG SER VAL ILE SEQRES 3 S 211 TRP TYR GLN GLN ARG PRO GLY GLN ALA PRO SER LEU ILE SEQRES 4 S 211 ILE TYR ASN ASN ASN ASP ARG PRO SER GLY ILE PRO ASP SEQRES 5 S 211 ARG PHE SER GLY SER PRO GLY SER THR PHE GLY THR THR SEQRES 6 S 211 ALA THR LEU THR ILE THR SER VAL GLU ALA GLY ASP GLU SEQRES 7 S 211 ALA ASP TYR TYR CYS HIS ILE TRP ASP SER ARG ARG PRO SEQRES 8 S 211 THR ASN TRP VAL PHE GLY GLU GLY THR THR LEU ILE VAL SEQRES 9 S 211 LEU SER GLN PRO LYS ALA ALA PRO SER VAL THR LEU PHE SEQRES 10 S 211 PRO PRO SER SER GLU GLU LEU GLN ALA ASN LYS ALA THR SEQRES 11 S 211 LEU VAL CYS LEU ILE SER ASP PHE TYR PRO GLY ALA VAL SEQRES 12 S 211 THR VAL ALA TRP LYS ALA ASP SER SER PRO VAL LYS ALA SEQRES 13 S 211 GLY VAL GLU THR THR THR PRO SER LYS GLN SER ASN ASN SEQRES 14 S 211 LYS TYR ALA ALA SER SER TYR LEU SER LEU THR PRO GLU SEQRES 15 S 211 GLN TRP LYS SER HIS LYS SER TYR SER CYS GLN VAL THR SEQRES 16 S 211 HIS GLU GLY SER THR VAL GLU LYS THR VAL ALA PRO THR SEQRES 17 S 211 GLU CYS SER HET NAG G 1 14 HET NAG G 2 14 HET NAG T 1 14 HET NAG T 2 14 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET NAG V 1 14 HET NAG V 2 14 HET BMA V 3 11 HET MAN V 4 11 HET MAN V 5 11 HET MAN V 6 11 HET NAG W 1 14 HET NAG W 2 14 HET NAG X 1 14 HET NAG X 2 14 HET NAG Y 1 14 HET NAG Y 2 14 HET BMA Y 3 11 HET MAN Y 4 11 HET NAG Z 1 14 HET NAG Z 2 14 HET BMA Z 3 11 HET MAN Z 4 11 HET MAN Z 5 11 HET NAG a 1 14 HET NAG a 2 14 HET NAG b 1 14 HET NAG b 2 14 HET NAG c 1 14 HET NAG c 2 14 HET BMA c 3 11 HET NAG d 1 14 HET NAG d 2 14 HET BMA d 3 11 HET NAG e 1 14 HET NAG e 2 14 HET BMA e 3 11 HET MAN e 4 11 HET MAN e 5 11 HET MAN e 6 11 HET MAN e 7 11 HET NAG f 1 14 HET NAG f 2 14 HET BMA f 3 11 HET MAN f 4 11 HET MAN f 5 11 HET NAG g 1 14 HET NAG g 2 14 HET NAG h 1 14 HET NAG h 2 14 HET NAG i 1 14 HET NAG i 2 14 HET BMA i 3 11 HET MAN i 4 11 HET MAN i 5 11 HET NAG j 1 14 HET NAG j 2 14 HET NAG k 1 14 HET NAG k 2 14 HET BMA k 3 11 HET MAN k 4 11 HET NAG l 1 14 HET NAG l 2 14 HET BMA l 3 11 HET NAG m 1 14 HET BMA m 2 11 HET NAG n 1 14 HET NAG n 2 14 HET NAG o 1 14 HET NAG o 2 14 HET BMA o 3 11 HET MAN o 4 11 HET MAN o 5 11 HET MAN o 6 11 HET MAN o 7 11 HET NAG p 1 14 HET NAG p 2 14 HET BMA p 3 11 HET NAG q 1 14 HET NAG q 2 14 HET NAG r 1 14 HET NAG r 2 14 HET BMA r 3 11 HET MAN r 4 11 HET MAN r 5 11 HET NAG A 601 14 HET NAG A 602 14 HET NAG A 603 14 HET NAG A 604 14 HET NAG A 605 14 HET NAG A 606 14 HET NAG A 607 14 HET NAG A 608 14 HET NAG A 609 14 HET NAG F 701 14 HET NAG D 701 14 HET NAG B 701 14 HET NAG E 601 14 HET NAG E 602 14 HET NAG E 603 14 HET NAG E 604 14 HET NAG E 605 14 HET NAG E 606 14 HET NAG E 607 14 HET NAG E 608 14 HET NAG C 601 14 HET NAG C 602 14 HET NAG C 603 14 HET NAG C 604 14 HET NAG C 605 14 HET NAG C 606 14 HET NAG C 607 14 HET NAG C 608 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 19 NAG 79(C8 H15 N O6) FORMUL 21 BMA 15(C6 H12 O6) FORMUL 21 MAN 22(C6 H12 O6) HELIX 1 AA1 ASN A 98 LYS A 117 1 20 HELIX 2 AA2 LEU A 122 CYS A 126 5 5 HELIX 3 AA3 LYS A 335 PHE A 353 1 19 HELIX 4 AA4 ASP A 368 THR A 373 1 6 HELIX 5 AA5 ASN A 425 ARG A 429 5 5 HELIX 6 AA6 THR F 529 SER F 534 1 6 HELIX 7 AA7 THR F 536 ASN F 543 1 8 HELIX 8 AA8 TRP F 571 TRP F 596 1 26 HELIX 9 AA9 LEU F 619 ASP F 624 1 6 HELIX 10 AB1 THR F 627 ILE F 635 1 9 HELIX 11 AB2 TYR F 638 LEU F 663 1 26 HELIX 12 AB3 LEU D 523 GLY D 527 5 5 HELIX 13 AB4 THR D 529 MET D 535 1 7 HELIX 14 AB5 THR D 536 ASN D 543 1 8 HELIX 15 AB6 THR D 569 TRP D 596 1 28 HELIX 16 AB7 ASN D 618 TRP D 623 1 6 HELIX 17 AB8 THR D 627 ILE D 635 1 9 HELIX 18 AB9 TYR D 638 LEU D 663 1 26 HELIX 19 AC1 LEU B 523 GLY B 527 5 5 HELIX 20 AC2 THR B 529 SER B 534 1 6 HELIX 21 AC3 THR B 536 ASN B 543 1 8 HELIX 22 AC4 ILE B 573 TRP B 596 1 24 HELIX 23 AC5 ASN B 618 ASN B 625 1 8 HELIX 24 AC6 THR B 627 ILE B 635 1 9 HELIX 25 AC7 TYR B 638 ALA B 662 1 25 HELIX 26 AC8 ASN E 98 LYS E 117 1 20 HELIX 27 AC9 LEU E 122 CYS E 126 5 5 HELIX 28 AD1 MET E 150 GLY E 152 5 3 HELIX 29 AD2 LYS E 335 GLY E 354 1 20 HELIX 30 AD3 ASP E 368 THR E 373 1 6 HELIX 31 AD4 ASN E 425 ARG E 429 5 5 HELIX 32 AD5 MET E 475 SER E 481 1 7 HELIX 33 AD6 ASN C 98 LYS C 117 1 20 HELIX 34 AD7 LEU C 122 CYS C 126 5 5 HELIX 35 AD8 LYS C 335 GLY C 354 1 20 HELIX 36 AD9 ASP C 368 THR C 373 1 6 HELIX 37 AE1 ARG C 476 SER C 481 1 6 HELIX 38 AE2 ASN H 28 TYR H 32 5 5 HELIX 39 AE3 TRP H 76 PHE H 78 5 3 HELIX 40 AE4 ARG H 91 THR H 95 5 5 HELIX 41 AE5 GLN I 79 ILE I 83 5 5 HELIX 42 AE6 LEU J 28 ASN J 32 5 5 HELIX 43 AE7 THR J 83 SER J 87 5 5 HELIX 44 AE8 GLU K 79 GLU K 83 5 5 HELIX 45 AE9 ASN M 28 TYR M 32 5 5 HELIX 46 AF1 TRP M 76 ASP M 79 5 4 HELIX 47 AF2 THR N 83 SER N 87 5 5 HELIX 48 AF3 GLU O 79 GLU O 83 5 5 HELIX 49 AF4 ASN P 28 TYR P 32 5 5 HELIX 50 AF5 ARG P 91 THR P 95 5 5 HELIX 51 AF6 LEU R 28 ASN R 32 5 5 HELIX 52 AF7 GLU S 79 GLU S 83 5 5 SHEET 1 AA1 3 LEU A 494 THR A 499 0 SHEET 2 AA1 3 TRP A 35 TYR A 40 -1 N TYR A 39 O GLY A 495 SHEET 3 AA1 3 ILE B 603 PRO B 609 -1 O VAL B 608 N VAL A 36 SHEET 1 AA2 5 TRP A 45 ASP A 47 0 SHEET 2 AA2 5 TYR A 486 ILE A 491 -1 O LYS A 490 N LYS A 46 SHEET 3 AA2 5 PHE A 223 CYS A 228 -1 N ALA A 224 O VAL A 489 SHEET 4 AA2 5 VAL A 242 VAL A 245 -1 O VAL A 245 N ILE A 225 SHEET 5 AA2 5 GLU A 83 LEU A 86 -1 N ILE A 84 O THR A 244 SHEET 1 AA3 2 GLU A 91 ASN A 94 0 SHEET 2 AA3 2 THR A 236 CYS A 239 -1 O GLY A 237 N PHE A 93 SHEET 1 AA4 5 LYS A 169 TYR A 177 0 SHEET 2 AA4 5 LEU A 154 THR A 162 -1 N PHE A 159 O VAL A 172 SHEET 3 AA4 5 LEU A 129 ASN A 133 -1 N THR A 132 O ASN A 156 SHEET 4 AA4 5 GLU A 190 LEU A 193 -1 O TYR A 191 N LEU A 129 SHEET 5 AA4 5 VAL A 181 GLN A 183 -1 N VAL A 182 O ARG A 192 SHEET 1 AA5 7 LEU A 260 LEU A 261 0 SHEET 2 AA5 7 ILE A 443 ARG A 456 -1 O THR A 450 N LEU A 260 SHEET 3 AA5 7 ILE A 284 ARG A 298 -1 N VAL A 292 O ILE A 449 SHEET 4 AA5 7 HIS A 330 SER A 334 -1 O ASN A 332 N ASN A 295 SHEET 5 AA5 7 SER A 413 LYS A 421 -1 O LEU A 416 N CYS A 331 SHEET 6 AA5 7 GLU A 381 CYS A 385 -1 N TYR A 384 O ARG A 419 SHEET 7 AA5 7 HIS A 374 CYS A 378 -1 N HIS A 374 O CYS A 385 SHEET 1 AA6 6 MET A 271 SER A 274 0 SHEET 2 AA6 6 ILE A 284 ARG A 298 -1 O LEU A 285 N ARG A 273 SHEET 3 AA6 6 ILE A 443 ARG A 456 -1 O ILE A 449 N VAL A 292 SHEET 4 AA6 6 GLU A 466 PRO A 470 -1 O ARG A 469 N THR A 455 SHEET 5 AA6 6 ILE A 359 PHE A 361 1 N ARG A 360 O GLU A 466 SHEET 6 AA6 6 SER A 393 TRP A 395 -1 O SER A 393 N PHE A 361 SHEET 1 AA7 2 THR A 303 GLY A 312 0 SHEET 2 AA7 2 GLN A 315 ASP A 322 -1 O ALA A 319 N LYS A 305 SHEET 1 AA8 3 ILE F 603 PRO F 609 0 SHEET 2 AA8 3 TRP E 35 TYR E 40 -1 O VAL E 36 N VAL F 608 SHEET 3 AA8 3 LEU E 494 THR E 499 -1 O ALA E 497 N THR E 37 SHEET 1 AA9 3 ILE D 603 PRO D 609 0 SHEET 2 AA9 3 TRP C 35 TYR C 39 -1 O VAL C 38 N CYS D 604 SHEET 3 AA9 3 GLY C 495 THR C 499 -1 O THR C 499 N TRP C 35 SHEET 1 AB1 5 TRP E 45 ASP E 47 0 SHEET 2 AB1 5 TYR E 486 ILE E 491 -1 O LYS E 490 N LYS E 46 SHEET 3 AB1 5 PHE E 223 CYS E 228 -1 N ALA E 224 O VAL E 489 SHEET 4 AB1 5 VAL E 242 VAL E 245 -1 O SER E 243 N LYS E 227 SHEET 5 AB1 5 GLU E 83 LEU E 86 -1 N ILE E 84 O THR E 244 SHEET 1 AB2 3 VAL E 75 PRO E 76 0 SHEET 2 AB2 3 PHE E 53 SER E 56 1 N SER E 56 O VAL E 75 SHEET 3 AB2 3 ILE E 215 CYS E 218 -1 O HIS E 216 N ALA E 55 SHEET 1 AB3 2 GLU E 91 ASN E 94 0 SHEET 2 AB3 2 THR E 236 CYS E 239 -1 O CYS E 239 N GLU E 91 SHEET 1 AB4 5 LYS E 169 TYR E 177 0 SHEET 2 AB4 5 LEU E 154 THR E 162 -1 N CYS E 157 O SER E 174 SHEET 3 AB4 5 LEU E 129 ASN E 133 -1 N GLN E 130 O SER E 158 SHEET 4 AB4 5 GLU E 190 LEU E 193 -1 O TYR E 191 N LEU E 129 SHEET 5 AB4 5 VAL E 181 GLN E 183 -1 N VAL E 182 O ARG E 192 SHEET 1 AB5 3 ILE E 201 GLN E 203 0 SHEET 2 AB5 3 ALA E 433 TYR E 435 1 O ALA E 433 N THR E 202 SHEET 3 AB5 3 ILE E 423 ILE E 424 -1 N ILE E 424 O MET E 434 SHEET 1 AB6 7 LEU E 260 LEU E 261 0 SHEET 2 AB6 7 ILE E 443 ARG E 456 -1 O THR E 450 N LEU E 260 SHEET 3 AB6 7 ILE E 284 ARG E 298 -1 N VAL E 292 O ILE E 449 SHEET 4 AB6 7 HIS E 330 SER E 334 -1 O HIS E 330 N THR E 297 SHEET 5 AB6 7 SER E 413 LYS E 421 -1 O ILE E 414 N VAL E 333 SHEET 6 AB6 7 GLU E 381 CYS E 385 -1 N TYR E 384 O ARG E 419 SHEET 7 AB6 7 HIS E 374 CYS E 378 -1 N CYS E 378 O GLU E 381 SHEET 1 AB7 6 MET E 271 ARG E 273 0 SHEET 2 AB7 6 ILE E 284 ARG E 298 -1 O LEU E 285 N ARG E 273 SHEET 3 AB7 6 ILE E 443 ARG E 456 -1 O ILE E 449 N VAL E 292 SHEET 4 AB7 6 GLU E 466 PRO E 470 -1 O ARG E 469 N THR E 455 SHEET 5 AB7 6 ILE E 359 PHE E 361 1 N ARG E 360 O PHE E 468 SHEET 6 AB7 6 SER E 393 TRP E 395 -1 O SER E 393 N PHE E 361 SHEET 1 AB8 2 THR E 303 GLY E 312 0 SHEET 2 AB8 2 GLN E 315 ASP E 322 -1 O ASP E 322 N THR E 303 SHEET 1 AB9 5 TRP C 45 ASP C 47 0 SHEET 2 AB9 5 TYR C 486 ILE C 491 -1 O LYS C 490 N LYS C 46 SHEET 3 AB9 5 PHE C 223 CYS C 228 -1 N ALA C 224 O VAL C 489 SHEET 4 AB9 5 VAL C 242 VAL C 245 -1 O VAL C 245 N ILE C 225 SHEET 5 AB9 5 GLU C 83 LEU C 86 -1 N ILE C 84 O THR C 244 SHEET 1 AC1 3 VAL C 75 PRO C 76 0 SHEET 2 AC1 3 PHE C 53 SER C 56 1 N CYS C 54 O VAL C 75 SHEET 3 AC1 3 HIS C 216 CYS C 218 -1 O CYS C 218 N PHE C 53 SHEET 1 AC2 2 GLU C 91 ASN C 94 0 SHEET 2 AC2 2 THR C 236 CYS C 239 -1 O CYS C 239 N GLU C 91 SHEET 1 AC3 3 LEU C 129 GLN C 130 0 SHEET 2 AC3 3 GLU C 190 LEU C 193 -1 O TYR C 191 N LEU C 129 SHEET 3 AC3 3 VAL C 181 GLN C 183 -1 N VAL C 182 O ARG C 192 SHEET 1 AC4 2 LEU C 154 LYS C 155 0 SHEET 2 AC4 2 PHE C 176 TYR C 177 -1 O PHE C 176 N LYS C 155 SHEET 1 AC5 2 SER C 158 THR C 162 0 SHEET 2 AC5 2 LYS C 169 TYR C 173 -1 O GLN C 170 N MET C 161 SHEET 1 AC6 3 ALA C 200 GLN C 203 0 SHEET 2 AC6 3 GLN C 432 TYR C 435 1 O ALA C 433 N ALA C 200 SHEET 3 AC6 3 ILE C 423 ILE C 424 -1 N ILE C 424 O MET C 434 SHEET 1 AC7 5 MET C 271 SER C 274 0 SHEET 2 AC7 5 ILE C 284 ARG C 298 -1 O LEU C 285 N ARG C 273 SHEET 3 AC7 5 ILE C 443 ARG C 456 -1 O ILE C 449 N VAL C 292 SHEET 4 AC7 5 THR C 467 PRO C 470 -1 O ARG C 469 N THR C 455 SHEET 5 AC7 5 ARG C 360 PHE C 361 1 N ARG C 360 O PHE C 468 SHEET 1 AC8 6 MET C 271 SER C 274 0 SHEET 2 AC8 6 ILE C 284 ARG C 298 -1 O LEU C 285 N ARG C 273 SHEET 3 AC8 6 HIS C 330 SER C 334 -1 O ASN C 332 N ASN C 295 SHEET 4 AC8 6 SER C 413 LYS C 421 -1 O ILE C 414 N VAL C 333 SHEET 5 AC8 6 GLU C 381 CYS C 385 -1 N TYR C 384 O ARG C 419 SHEET 6 AC8 6 HIS C 374 CYS C 378 -1 N CYS C 378 O GLU C 381 SHEET 1 AC9 2 ASN C 302 GLY C 312 0 SHEET 2 AC9 2 GLN C 315 ILE C 323 -1 O ALA C 319 N LYS C 305 SHEET 1 AD1 4 GLN H 3 GLN H 6 0 SHEET 2 AD1 4 VAL H 18 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AD1 4 THR H 80 LEU H 87 -1 O TYR H 81 N ALA H 24 SHEET 4 AD1 4 VAL H 68 ALA H 74 -1 N THR H 71 O TYR H 84 SHEET 1 AD2 6 ALA H 10 VAL H 11 0 SHEET 2 AD2 6 THR H 117 THR H 120 1 O THR H 120 N ALA H 10 SHEET 3 AD2 6 ALA H 96 GLN H 103 -1 N ALA H 96 O VAL H 119 SHEET 4 AD2 6 PHE H 33 GLN H 39 -1 N GLN H 39 O VAL H 97 SHEET 5 AD2 6 LEU H 45 ILE H 51 -1 O GLY H 49 N TRP H 36 SHEET 6 AD2 6 PRO H 58 ASN H 59 -1 O ASN H 59 N TRP H 50 SHEET 1 AD3 4 MET I 4 SER I 7 0 SHEET 2 AD3 4 THR I 22 ALA I 25 -1 O GLN I 24 N THR I 5 SHEET 3 AD3 4 GLU I 70 TYR I 71 -1 O TYR I 71 N CYS I 23 SHEET 4 AD3 4 ARG I 66 TRP I 67 -1 N TRP I 67 O GLU I 70 SHEET 1 AD4 5 SER I 10 SER I 12 0 SHEET 2 AD4 5 THR I 102 ASP I 105 1 O ARG I 103 N LEU I 11 SHEET 3 AD4 5 THR I 85 VAL I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AD4 5 LEU I 33 GLN I 38 -1 N ASN I 34 O GLN I 89 SHEET 5 AD4 5 LYS I 45 TYR I 49 -1 O ILE I 48 N TRP I 35 SHEET 1 AD5 4 SER I 10 SER I 12 0 SHEET 2 AD5 4 THR I 102 ASP I 105 1 O ARG I 103 N LEU I 11 SHEET 3 AD5 4 THR I 85 VAL I 90 -1 N TYR I 86 O THR I 102 SHEET 4 AD5 4 PHE I 97 VAL I 98 -1 O PHE I 97 N VAL I 90 SHEET 1 AD6 2 PHE I 62 SER I 63 0 SHEET 2 AD6 2 THR I 74 ILE I 75 -1 O THR I 74 N SER I 63 SHEET 1 AD7 4 HIS J 3 SER J 7 0 SHEET 2 AD7 4 LEU J 18 SER J 25 -1 O ASN J 23 N GLN J 5 SHEET 3 AD7 4 LEU J 77 LEU J 82 -1 O VAL J 78 N CYS J 22 SHEET 4 AD7 4 VAL J 67 ASP J 72 -1 N ASP J 72 O LEU J 77 SHEET 1 AD8 5 LEU J 11 VAL J 12 0 SHEET 2 AD8 5 THR J 107 VAL J 111 1 O THR J 110 N VAL J 12 SHEET 3 AD8 5 ALA J 88 THR J 95 -1 N ALA J 88 O VAL J 109 SHEET 4 AD8 5 TYR J 33 GLN J 39 -1 N GLN J 39 O ILE J 89 SHEET 5 AD8 5 GLU J 46 VAL J 51 -1 O GLU J 46 N ARG J 38 SHEET 1 AD9 4 LEU J 11 VAL J 12 0 SHEET 2 AD9 4 THR J 107 VAL J 111 1 O THR J 110 N VAL J 12 SHEET 3 AD9 4 ALA J 88 THR J 95 -1 N ALA J 88 O VAL J 109 SHEET 4 AD9 4 MET J 100P VAL J 102 -1 O ASP J 101 N THR J 94 SHEET 1 AE1 2 ARG J 100 ILE J 100A 0 SHEET 2 AE1 2 TRP J 100J PHE J 100K-1 O PHE J 100K N ARG J 100 SHEET 1 AE2 3 PHE K 6 VAL K 13 0 SHEET 2 AE2 3 THR K 102 VAL K 106 1 O THR K 103 N VAL K 11 SHEET 3 AE2 3 ALA K 84 TYR K 86 -1 N ALA K 84 O LEU K 104 SHEET 1 AE3 3 ALA K 19 CYS K 23 0 SHEET 2 AE3 3 ALA K 71 ILE K 75 -1 O LEU K 73 N ILE K 21 SHEET 3 AE3 3 PHE K 62 GLY K 64 -1 N SER K 63 O THR K 74 SHEET 1 AE4 3 PRO K 44 ILE K 48 0 SHEET 2 AE4 3 ARG K 31 GLN K 38 -1 N TRP K 35 O ILE K 48 SHEET 3 AE4 3 CYS K 88 ASP K 92 -1 O HIS K 89 N ILE K 34 SHEET 1 AE5 4 GLN M 3 GLN M 6 0 SHEET 2 AE5 4 VAL M 20 SER M 25 -1 O SER M 25 N GLN M 3 SHEET 3 AE5 4 TYR M 81 LEU M 87 -1 O PHE M 83 N CYS M 22 SHEET 4 AE5 4 VAL M 68 ALA M 74 -1 N THR M 71 O TYR M 84 SHEET 1 AE6 6 ALA M 10 VAL M 11 0 SHEET 2 AE6 6 THR M 117 THR M 120 1 O THR M 120 N ALA M 10 SHEET 3 AE6 6 VAL M 97 GLN M 103 -1 N TYR M 98 O THR M 117 SHEET 4 AE6 6 ILE M 34 GLN M 39 -1 N TRP M 37 O PHE M 99 SHEET 5 AE6 6 LEU M 45 ILE M 51 -1 O VAL M 48 N TRP M 36 SHEET 6 AE6 6 PRO M 58 ASN M 59 -1 O ASN M 59 N TRP M 50 SHEET 1 AE7 4 ALA M 10 VAL M 11 0 SHEET 2 AE7 4 THR M 117 THR M 120 1 O THR M 120 N ALA M 10 SHEET 3 AE7 4 VAL M 97 GLN M 103 -1 N TYR M 98 O THR M 117 SHEET 4 AE7 4 PHE M 110 TRP M 113 -1 O VAL M 112 N ARG M 102 SHEET 1 AE8 4 MET L 4 GLN L 6 0 SHEET 2 AE8 4 CYS L 23 ALA L 25 -1 O GLN L 24 N THR L 5 SHEET 3 AE8 4 GLU L 70 TYR L 71 -1 O TYR L 71 N CYS L 23 SHEET 4 AE8 4 ARG L 66 TRP L 67 -1 N TRP L 67 O GLU L 70 SHEET 1 AE9 3 VAL L 19 THR L 20 0 SHEET 2 AE9 3 THR L 74 ILE L 75 -1 O ILE L 75 N VAL L 19 SHEET 3 AE9 3 PHE L 62 SER L 63 -1 N SER L 63 O THR L 74 SHEET 1 AF1 4 LYS L 45 ILE L 48 0 SHEET 2 AF1 4 LEU L 33 GLN L 38 -1 N TRP L 35 O ILE L 48 SHEET 3 AF1 4 THR L 85 VAL L 90 -1 O PHE L 87 N TYR L 36 SHEET 4 AF1 4 PHE L 97 VAL L 98 -1 O PHE L 97 N VAL L 90 SHEET 1 AF2 4 LYS L 45 ILE L 48 0 SHEET 2 AF2 4 LEU L 33 GLN L 38 -1 N TRP L 35 O ILE L 48 SHEET 3 AF2 4 THR L 85 VAL L 90 -1 O PHE L 87 N TYR L 36 SHEET 4 AF2 4 THR L 102 ARG L 103 -1 O THR L 102 N TYR L 86 SHEET 1 AF3 4 HIS N 3 SER N 7 0 SHEET 2 AF3 4 LEU N 18 SER N 25 -1 O ASN N 23 N GLN N 5 SHEET 3 AF3 4 LEU N 77 LEU N 82 -1 O VAL N 78 N CYS N 22 SHEET 4 AF3 4 VAL N 67 ASP N 72 -1 N HIS N 68 O ARG N 81 SHEET 1 AF4 5 ASN N 58 TYR N 59 0 SHEET 2 AF4 5 GLU N 46 VAL N 51 -1 N TYR N 50 O ASN N 58 SHEET 3 AF4 5 TYR N 33 GLN N 39 -1 N ARG N 38 O GLU N 46 SHEET 4 AF4 5 ALA N 88 LYS N 96 -1 O ALA N 93 N SER N 35 SHEET 5 AF4 5 TYR N 100O TRP N 103 -1 O VAL N 102 N THR N 94 SHEET 1 AF5 5 ASN N 58 TYR N 59 0 SHEET 2 AF5 5 GLU N 46 VAL N 51 -1 N TYR N 50 O ASN N 58 SHEET 3 AF5 5 TYR N 33 GLN N 39 -1 N ARG N 38 O GLU N 46 SHEET 4 AF5 5 ALA N 88 LYS N 96 -1 O ALA N 93 N SER N 35 SHEET 5 AF5 5 THR N 107 VAL N 109 -1 O THR N 107 N TYR N 90 SHEET 1 AF6 2 ARG N 100 ILE N 100A 0 SHEET 2 AF6 2 TRP N 100J PHE N 100K-1 O PHE N 100K N ARG N 100 SHEET 1 AF7 5 PHE O 6 VAL O 13 0 SHEET 2 AF7 5 GLY O 99 VAL O 106 1 O ILE O 105 N VAL O 11 SHEET 3 AF7 5 ALA O 84 ASP O 92 -1 N TYR O 86 O THR O 102 SHEET 4 AF7 5 ARG O 31 GLN O 38 -1 N ILE O 34 O HIS O 89 SHEET 5 AF7 5 PRO O 44 ILE O 48 -1 O ILE O 48 N TRP O 35 SHEET 1 AF8 3 ALA O 19 CYS O 23 0 SHEET 2 AF8 3 ALA O 71 ILE O 75 -1 O ALA O 71 N CYS O 23 SHEET 3 AF8 3 PHE O 62 GLY O 64 -1 N SER O 63 O THR O 74 SHEET 1 AF9 4 GLN P 3 GLN P 6 0 SHEET 2 AF9 4 VAL P 18 SER P 25 -1 O GLU P 23 N LEU P 5 SHEET 3 AF9 4 TYR P 81 LEU P 87 -1 O PHE P 83 N CYS P 22 SHEET 4 AF9 4 SER P 69 ALA P 74 -1 N THR P 71 O TYR P 84 SHEET 1 AG1 6 ALA P 10 VAL P 11 0 SHEET 2 AG1 6 THR P 117 THR P 120 1 O GLN P 118 N ALA P 10 SHEET 3 AG1 6 ALA P 96 GLN P 103 -1 N ALA P 96 O VAL P 119 SHEET 4 AG1 6 ILE P 34 GLN P 39 -1 N GLN P 39 O VAL P 97 SHEET 5 AG1 6 LEU P 45 ILE P 51 -1 O ILE P 51 N ILE P 34 SHEET 6 AG1 6 PRO P 58 ASN P 59 -1 O ASN P 59 N TRP P 50 SHEET 1 AG2 4 ALA P 10 VAL P 11 0 SHEET 2 AG2 4 THR P 117 THR P 120 1 O GLN P 118 N ALA P 10 SHEET 3 AG2 4 ALA P 96 GLN P 103 -1 N ALA P 96 O VAL P 119 SHEET 4 AG2 4 PHE P 110 TRP P 113 -1 O VAL P 112 N ARG P 102 SHEET 1 AG3 4 MET Q 4 GLN Q 6 0 SHEET 2 AG3 4 CYS Q 23 ALA Q 25 -1 O GLN Q 24 N THR Q 5 SHEET 3 AG3 4 GLU Q 70 TYR Q 71 -1 O TYR Q 71 N CYS Q 23 SHEET 4 AG3 4 ARG Q 66 TRP Q 67 -1 N TRP Q 67 O GLU Q 70 SHEET 1 AG4 5 SER Q 10 SER Q 12 0 SHEET 2 AG4 5 THR Q 102 ASP Q 105 1 O ASP Q 105 N LEU Q 11 SHEET 3 AG4 5 THR Q 85 VAL Q 90 -1 N TYR Q 86 O THR Q 102 SHEET 4 AG4 5 LEU Q 33 GLN Q 38 -1 N TYR Q 36 O PHE Q 87 SHEET 5 AG4 5 LYS Q 45 ILE Q 48 -1 O ILE Q 48 N TRP Q 35 SHEET 1 AG5 4 SER Q 10 SER Q 12 0 SHEET 2 AG5 4 THR Q 102 ASP Q 105 1 O ASP Q 105 N LEU Q 11 SHEET 3 AG5 4 THR Q 85 VAL Q 90 -1 N TYR Q 86 O THR Q 102 SHEET 4 AG5 4 PHE Q 97 VAL Q 98 -1 O PHE Q 97 N VAL Q 90 SHEET 1 AG6 2 VAL Q 19 THR Q 20 0 SHEET 2 AG6 2 THR Q 74 ILE Q 75 -1 O ILE Q 75 N VAL Q 19 SHEET 1 AG7 4 HIS R 3 SER R 7 0 SHEET 2 AG7 4 LEU R 18 SER R 25 -1 O SER R 25 N HIS R 3 SHEET 3 AG7 4 LEU R 77 LEU R 82 -1 O VAL R 78 N CYS R 22 SHEET 4 AG7 4 VAL R 67 ASP R 72 -1 N HIS R 68 O ARG R 81 SHEET 1 AG8 4 THR R 57 TYR R 59 0 SHEET 2 AG8 4 GLU R 46 VAL R 51 -1 N TYR R 50 O ASN R 58 SHEET 3 AG8 4 TYR R 33 GLN R 39 -1 N TRP R 34 O VAL R 51 SHEET 4 AG8 4 ILE R 89 THR R 95 -1 O ALA R 93 N SER R 35 SHEET 1 AG9 2 ARG R 99 ILE R 100A 0 SHEET 2 AG9 2 TRP R 100J THR R 100L-1 O PHE R 100K N ARG R 100 SHEET 1 AH1 4 PHE S 6 VAL S 13 0 SHEET 2 AH1 4 THR S 102 VAL S 106 1 O THR S 103 N VAL S 11 SHEET 3 AH1 4 ALA S 84 HIS S 89 -1 N TYR S 86 O THR S 102 SHEET 4 AH1 4 ILE S 34 GLN S 38 -1 N GLN S 38 O ASP S 85 SHEET 1 AH2 3 ALA S 19 GLU S 26 0 SHEET 2 AH2 3 THR S 70 ILE S 75 -1 O ALA S 71 N CYS S 23 SHEET 3 AH2 3 SER S 63 GLY S 64 -1 N SER S 63 O THR S 74 SSBOND 1 CYS A 54 CYS A 74 1555 1555 2.01 SSBOND 2 CYS A 119 CYS A 205 1555 1555 2.03 SSBOND 3 CYS A 126 CYS A 196 1555 1555 2.03 SSBOND 4 CYS A 131 CYS A 157 1555 1555 2.03 SSBOND 5 CYS A 218 CYS A 247 1555 1555 2.05 SSBOND 6 CYS A 228 CYS A 239 1555 1555 2.03 SSBOND 7 CYS A 296 CYS A 331 1555 1555 2.05 SSBOND 8 CYS A 296 CYS A 445 1555 1555 2.05 SSBOND 9 CYS A 378 CYS A 445 1555 1555 2.04 SSBOND 10 CYS A 385 CYS A 418 1555 1555 2.04 SSBOND 11 CYS A 501 CYS B 605 1555 1555 2.03 SSBOND 12 CYS F 598 CYS F 604 1555 1555 2.03 SSBOND 13 CYS F 605 CYS E 501 1555 1555 2.03 SSBOND 14 CYS D 598 CYS D 604 1555 1555 2.03 SSBOND 15 CYS D 605 CYS C 501 1555 1555 2.02 SSBOND 16 CYS B 598 CYS B 604 1555 1555 2.03 SSBOND 17 CYS E 54 CYS E 74 1555 1555 2.03 SSBOND 18 CYS E 119 CYS E 205 1555 1555 2.03 SSBOND 19 CYS E 126 CYS E 196 1555 1555 2.03 SSBOND 20 CYS E 131 CYS E 157 1555 1555 2.03 SSBOND 21 CYS E 218 CYS E 247 1555 1555 2.03 SSBOND 22 CYS E 228 CYS E 239 1555 1555 2.03 SSBOND 23 CYS E 296 CYS E 331 1555 1555 2.02 SSBOND 24 CYS E 378 CYS E 445 1555 1555 2.03 SSBOND 25 CYS E 385 CYS E 418 1555 1555 2.03 SSBOND 26 CYS C 54 CYS C 74 1555 1555 2.03 SSBOND 27 CYS C 119 CYS C 205 1555 1555 2.04 SSBOND 28 CYS C 126 CYS C 196 1555 1555 2.03 SSBOND 29 CYS C 131 CYS C 157 1555 1555 2.03 SSBOND 30 CYS C 218 CYS C 247 1555 1555 2.02 SSBOND 31 CYS C 228 CYS C 239 1555 1555 2.03 SSBOND 32 CYS C 296 CYS C 331 1555 1555 2.03 SSBOND 33 CYS C 378 CYS C 445 1555 1555 2.03 SSBOND 34 CYS C 385 CYS C 418 1555 1555 2.03 SSBOND 35 CYS H 22 CYS H 100 1555 1555 2.02 SSBOND 36 CYS I 23 CYS I 88 1555 1555 2.03 SSBOND 37 CYS J 22 CYS J 92 1555 1555 2.04 SSBOND 38 CYS K 23 CYS K 88 1555 1555 2.03 SSBOND 39 CYS M 22 CYS M 100 1555 1555 2.03 SSBOND 40 CYS L 23 CYS L 88 1555 1555 2.04 SSBOND 41 CYS N 22 CYS N 92 1555 1555 2.04 SSBOND 42 CYS O 23 CYS O 88 1555 1555 2.03 SSBOND 43 CYS P 22 CYS P 100 1555 1555 2.03 SSBOND 44 CYS Q 23 CYS Q 88 1555 1555 2.04 SSBOND 45 CYS R 22 CYS R 92 1555 1555 2.03 SSBOND 46 CYS S 23 CYS S 88 1555 1555 2.03 LINK ND2 ASN A 88 C1 NAG A 601 1555 1555 1.44 LINK ND2 ASN A 133 C1 NAG A 602 1555 1555 1.44 LINK ND2 ASN A 137 C1 NAG Z 1 1555 1555 1.43 LINK ND2 ASN A 156 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN A 160 C1 NAG A 603 1555 1555 1.44 LINK ND2 ASN A 197 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN A 234 C1 NAG A 604 1555 1555 1.44 LINK ND2 ASN A 262 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN A 276 C1 NAG Y 1 1555 1555 1.45 LINK ND2 ASN A 295 C1 NAG A 605 1555 1555 1.43 LINK ND2 ASN A 301 C1 NAG A 606 1555 1555 1.44 LINK ND2 ASN A 332 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN A 339 C1 NAG A 607 1555 1555 1.44 LINK ND2 ASN A 363 C1 NAG W 1 1555 1555 1.45 LINK ND2 ASN A 386 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN A 392 C1 NAG A 608 1555 1555 1.44 LINK ND2 ASN A 448 C1 NAG A 609 1555 1555 1.44 LINK ND2 ASN F 637 C1 NAG F 701 1555 1555 1.45 LINK ND2 ASN D 637 C1 NAG D 701 1555 1555 1.45 LINK ND2 ASN B 637 C1 NAG B 701 1555 1555 1.44 LINK ND2 ASN E 88 C1 NAG E 601 1555 1555 1.44 LINK ND2 ASN E 133 C1 NAG E 602 1555 1555 1.44 LINK ND2 ASN E 137 C1 NAG i 1 1555 1555 1.46 LINK ND2 ASN E 156 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN E 160 C1 NAG E 603 1555 1555 1.44 LINK ND2 ASN E 197 C1 NAG b 1 1555 1555 1.44 LINK ND2 ASN E 234 C1 NAG E 604 1555 1555 1.44 LINK ND2 ASN E 262 C1 NAG c 1 1555 1555 1.44 LINK ND2 ASN E 276 C1 NAG d 1 1555 1555 1.43 LINK ND2 ASN E 295 C1 NAG E 605 1555 1555 1.44 LINK ND2 ASN E 301 C1 NAG E 606 1555 1555 1.44 LINK ND2 ASN E 332 C1 NAG e 1 1555 1555 1.43 LINK ND2 ASN E 339 C1 NAG E 607 1555 1555 1.44 LINK ND2 ASN E 363 C1 NAG f 1 1555 1555 1.44 LINK ND2 ASN E 386 C1 NAG g 1 1555 1555 1.44 LINK ND2 ASN E 392 C1 NAG E 608 1555 1555 1.44 LINK ND2 ASN E 448 C1 NAG h 1 1555 1555 1.46 LINK ND2 ASN C 88 C1 NAG C 608 1555 1555 1.46 LINK ND2 ASN C 133 C1 NAG C 601 1555 1555 1.44 LINK ND2 ASN C 137 C1 NAG r 1 1555 1555 1.44 LINK ND2 ASN C 156 C1 NAG j 1 1555 1555 1.44 LINK ND2 ASN C 160 C1 NAG C 602 1555 1555 1.43 LINK ND2 ASN C 197 C1 NAG C 603 1555 1555 1.44 LINK ND2 ASN C 234 C1 NAG C 604 1555 1555 1.46 LINK ND2 ASN C 262 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN C 276 C1 NAG l 1 1555 1555 1.44 LINK ND2 ASN C 295 C1 NAG m 1 1555 1555 1.43 LINK ND2 ASN C 301 C1 NAG n 1 1555 1555 1.44 LINK ND2 ASN C 332 C1 NAG o 1 1555 1555 1.43 LINK ND2 ASN C 339 C1 NAG C 605 1555 1555 1.46 LINK ND2 ASN C 363 C1 NAG p 1 1555 1555 1.43 LINK ND2 ASN C 386 C1 NAG q 1 1555 1555 1.43 LINK ND2 ASN C 392 C1 NAG C 606 1555 1555 1.44 LINK ND2 ASN C 448 C1 NAG C 607 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.45 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.45 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.45 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.45 LINK O4 NAG V 2 C1 BMA V 3 1555 1555 1.44 LINK O3 BMA V 3 C1 MAN V 4 1555 1555 1.45 LINK O6 BMA V 3 C1 MAN V 6 1555 1555 1.45 LINK O2 MAN V 4 C1 MAN V 5 1555 1555 1.45 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.45 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.44 LINK O4 NAG Y 2 C1 BMA Y 3 1555 1555 1.46 LINK O6 BMA Y 3 C1 MAN Y 4 1555 1555 1.44 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.45 LINK O4 NAG Z 2 C1 BMA Z 3 1555 1555 1.44 LINK O3 BMA Z 3 C1 MAN Z 4 1555 1555 1.45 LINK O6 BMA Z 3 C1 MAN Z 5 1555 1555 1.44 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 LINK O4 NAG b 1 C1 NAG b 2 1555 1555 1.45 LINK O4 NAG c 1 C1 NAG c 2 1555 1555 1.45 LINK O4 NAG c 2 C1 BMA c 3 1555 1555 1.45 LINK O4 NAG d 1 C1 NAG d 2 1555 1555 1.45 LINK O4 NAG d 2 C1 BMA d 3 1555 1555 1.44 LINK O4 NAG e 1 C1 NAG e 2 1555 1555 1.44 LINK O4 NAG e 2 C1 BMA e 3 1555 1555 1.44 LINK O3 BMA e 3 C1 MAN e 4 1555 1555 1.45 LINK O6 BMA e 3 C1 MAN e 7 1555 1555 1.44 LINK O2 MAN e 4 C1 MAN e 5 1555 1555 1.45 LINK O2 MAN e 5 C1 MAN e 6 1555 1555 1.44 LINK O4 NAG f 1 C1 NAG f 2 1555 1555 1.44 LINK O4 NAG f 2 C1 BMA f 3 1555 1555 1.45 LINK O3 BMA f 3 C1 MAN f 4 1555 1555 1.45 LINK O6 BMA f 3 C1 MAN f 5 1555 1555 1.45 LINK O4 NAG g 1 C1 NAG g 2 1555 1555 1.47 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.44 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.45 LINK O4 NAG i 2 C1 BMA i 3 1555 1555 1.44 LINK O3 BMA i 3 C1 MAN i 4 1555 1555 1.45 LINK O6 BMA i 3 C1 MAN i 5 1555 1555 1.45 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.45 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.46 LINK O4 NAG k 2 C1 BMA k 3 1555 1555 1.47 LINK O6 BMA k 3 C1 MAN k 4 1555 1555 1.46 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.44 LINK O4 NAG l 2 C1 BMA l 3 1555 1555 1.47 LINK O4 NAG m 1 C1 BMA m 2 1555 1555 1.45 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.44 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.44 LINK O4 NAG o 2 C1 BMA o 3 1555 1555 1.44 LINK O3 BMA o 3 C1 MAN o 4 1555 1555 1.45 LINK O6 BMA o 3 C1 MAN o 7 1555 1555 1.45 LINK O2 MAN o 4 C1 MAN o 5 1555 1555 1.44 LINK O2 MAN o 5 C1 MAN o 6 1555 1555 1.44 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.44 LINK O4 NAG p 2 C1 BMA p 3 1555 1555 1.45 LINK O4 NAG q 1 C1 NAG q 2 1555 1555 1.45 LINK O4 NAG r 1 C1 NAG r 2 1555 1555 1.45 LINK O4 NAG r 2 C1 BMA r 3 1555 1555 1.47 LINK O3 BMA r 3 C1 MAN r 4 1555 1555 1.44 LINK O6 BMA r 3 C1 MAN r 5 1555 1555 1.45 CISPEP 1 SER I 7 PRO I 8 0 -5.63 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000