HEADER VIRAL PROTEIN/IMMUNE SYSTEM 15-MAY-25 9OOG TITLE CRYO-EM STRUCTURE OF VACCINE-ELICITED ANTIBODY T3_NB_G05 IN COMPLEX TITLE 2 WITH HIV ENV TRIMER Q23-APEX-GT1.N187S COMPND MOL_ID: 1; COMPND 2 MOLECULE: T3_NB_G05 HEAVY CHAIN; COMPND 3 CHAIN: H, I, J; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: T3_NB_G05 LIGHT CHAIN; COMPND 7 CHAIN: L, M, N; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: HIV ENV GP120; COMPND 11 CHAIN: b, d, f; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 4; COMPND 14 MOLECULE: HIV ENV GP41 ECTODOMAIN; COMPND 15 CHAIN: c, e, g; COMPND 16 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 3 ORGANISM_TAXID: 10090; SOURCE 4 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 8 ORGANISM_TAXID: 10090; SOURCE 9 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 10 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_TAXID: 9606; SOURCE 14 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 15 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 16 MOL_ID: 4; SOURCE 17 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 18 ORGANISM_TAXID: 9606; SOURCE 19 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 20 EXPRESSION_SYSTEM_TAXID: 9606 KEYWDS IMMUNE COMPLEX, NEUTRALIZING ANTIBODY, V2 APEX, MOUSE MODEL, VIRAL KEYWDS 2 PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR R.S.ROARK,L.S.SHAPIRO,P.D.KWONG REVDAT 1 12-NOV-25 9OOG 0 JRNL AUTH G.AMRIT,R.S.ROARK,P.D.KWONG,F.D.BATISTA JRNL TITL RAPID ACQUISITION OF HIV-1 NEUTRALIZATION BREADTH IN A JRNL TITL 2 RHESUS V2 APEX GERMLINE ANTIBODY MOUSE MODEL WITH A SINGLE JRNL TITL 3 BOLUS PRIMING IMMUNIZATION JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.10 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.100 REMARK 3 NUMBER OF PARTICLES : 211700 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9OOG COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 16-MAY-25. REMARK 100 THE DEPOSITION ID IS D_1000295877. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : T3_NB_G05 FAB IN COMPLEX WITH REMARK 245 HIV ENV TRIMER Q23-APEX- REMARK 245 GT1.N187S REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.50 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 800.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5800.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 12-MERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 12-MERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, b, c, I, M, d, e, J, N, REMARK 350 AND CHAINS: f, g, A, B, C, D, E, F, G, REMARK 350 AND CHAINS: K, O, P, Q, R, S, T, U, V, W, REMARK 350 AND CHAINS: X, Y, Z, a, h, i, j, k, l, REMARK 350 AND CHAINS: m, n, o, p, q, r, s, t, u, v, REMARK 350 AND CHAINS: w, x REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 ALA H 114 REMARK 465 SER H 115 REMARK 465 THR H 116 REMARK 465 THR H 117 REMARK 465 PRO H 118 REMARK 465 PRO H 119 REMARK 465 SER H 120 REMARK 465 VAL H 121 REMARK 465 TYR H 122 REMARK 465 PRO H 123 REMARK 465 LEU H 124 REMARK 465 ALA H 125 REMARK 465 PRO H 126 REMARK 465 GLY H 127 REMARK 465 SER H 128 REMARK 465 ALA H 129 REMARK 465 ALA H 130 REMARK 465 GLN H 131 REMARK 465 THR H 132 REMARK 465 ASN H 133 REMARK 465 SER H 134 REMARK 465 MET H 135 REMARK 465 VAL H 136 REMARK 465 THR H 137 REMARK 465 LEU H 138 REMARK 465 GLY H 139 REMARK 465 CYS H 140 REMARK 465 LEU H 141 REMARK 465 VAL H 142 REMARK 465 LYS H 143 REMARK 465 GLY H 144 REMARK 465 TYR H 145 REMARK 465 PHE H 146 REMARK 465 PRO H 147 REMARK 465 GLU H 148 REMARK 465 PRO H 149 REMARK 465 VAL H 150 REMARK 465 THR H 151 REMARK 465 VAL H 152 REMARK 465 THR H 153 REMARK 465 TRP H 154 REMARK 465 ASN H 155 REMARK 465 SER H 156 REMARK 465 GLY H 157 REMARK 465 SER H 158 REMARK 465 LEU H 159 REMARK 465 SER H 160 REMARK 465 SER H 161 REMARK 465 GLY H 162 REMARK 465 VAL H 163 REMARK 465 HIS H 164 REMARK 465 THR H 165 REMARK 465 PHE H 166 REMARK 465 PRO H 167 REMARK 465 ALA H 168 REMARK 465 VAL H 169 REMARK 465 LEU H 170 REMARK 465 GLN H 171 REMARK 465 SER H 172 REMARK 465 ASP H 173 REMARK 465 LEU H 174 REMARK 465 TYR H 175 REMARK 465 THR H 176 REMARK 465 LEU H 177 REMARK 465 SER H 178 REMARK 465 SER H 179 REMARK 465 SER H 180 REMARK 465 VAL H 181 REMARK 465 THR H 182 REMARK 465 VAL H 183 REMARK 465 PRO H 184 REMARK 465 SER H 185 REMARK 465 SER H 186 REMARK 465 THR H 187 REMARK 465 TRP H 188 REMARK 465 PRO H 189 REMARK 465 SER H 190 REMARK 465 GLU H 191 REMARK 465 THR H 192 REMARK 465 VAL H 193 REMARK 465 THR H 194 REMARK 465 CYS H 195 REMARK 465 ASN H 196 REMARK 465 VAL H 197 REMARK 465 ALA H 198 REMARK 465 HIS H 199 REMARK 465 PRO H 200 REMARK 465 ALA H 201 REMARK 465 SER H 202 REMARK 465 SER H 203 REMARK 465 THR H 204 REMARK 465 LYS H 205 REMARK 465 VAL H 206 REMARK 465 ASP H 207 REMARK 465 LYS H 208 REMARK 465 LYS H 209 REMARK 465 ILE H 210 REMARK 465 VAL H 211 REMARK 465 PRO H 212 REMARK 465 ARG H 213 REMARK 465 ASP H 214 REMARK 465 CYS H 215 REMARK 465 GLY H 216 REMARK 465 ARG L 108 REMARK 465 THR L 109 REMARK 465 ASP L 110 REMARK 465 ALA L 111 REMARK 465 ALA L 112 REMARK 465 PRO L 113 REMARK 465 THR L 114 REMARK 465 VAL L 115 REMARK 465 SER L 116 REMARK 465 ILE L 117 REMARK 465 PHE L 118 REMARK 465 PRO L 119 REMARK 465 PRO L 120 REMARK 465 SER L 121 REMARK 465 SER L 122 REMARK 465 GLU L 123 REMARK 465 GLN L 124 REMARK 465 LEU L 125 REMARK 465 THR L 126 REMARK 465 SER L 127 REMARK 465 GLY L 128 REMARK 465 GLY L 129 REMARK 465 ALA L 130 REMARK 465 SER L 131 REMARK 465 VAL L 132 REMARK 465 VAL L 133 REMARK 465 CYS L 134 REMARK 465 PHE L 135 REMARK 465 LEU L 136 REMARK 465 ASN L 137 REMARK 465 ASN L 138 REMARK 465 PHE L 139 REMARK 465 TYR L 140 REMARK 465 PRO L 141 REMARK 465 LYS L 142 REMARK 465 ASP L 143 REMARK 465 ILE L 144 REMARK 465 ASN L 145 REMARK 465 VAL L 146 REMARK 465 LYS L 147 REMARK 465 TRP L 148 REMARK 465 LYS L 149 REMARK 465 ILE L 150 REMARK 465 ASP L 151 REMARK 465 GLY L 152 REMARK 465 SER L 153 REMARK 465 GLU L 154 REMARK 465 ARG L 155 REMARK 465 GLN L 156 REMARK 465 ASN L 157 REMARK 465 GLY L 158 REMARK 465 VAL L 159 REMARK 465 LEU L 160 REMARK 465 ASN L 161 REMARK 465 SER L 162 REMARK 465 TRP L 163 REMARK 465 THR L 164 REMARK 465 ASP L 165 REMARK 465 GLN L 166 REMARK 465 ASP L 167 REMARK 465 SER L 168 REMARK 465 LYS L 169 REMARK 465 ASP L 170 REMARK 465 SER L 171 REMARK 465 THR L 172 REMARK 465 TYR L 173 REMARK 465 SER L 174 REMARK 465 MET L 175 REMARK 465 SER L 176 REMARK 465 SER L 177 REMARK 465 THR L 178 REMARK 465 LEU L 179 REMARK 465 THR L 180 REMARK 465 LEU L 181 REMARK 465 THR L 182 REMARK 465 LYS L 183 REMARK 465 ASP L 184 REMARK 465 GLU L 185 REMARK 465 TYR L 186 REMARK 465 GLU L 187 REMARK 465 ARG L 188 REMARK 465 HIS L 189 REMARK 465 ASN L 190 REMARK 465 SER L 191 REMARK 465 TYR L 192 REMARK 465 THR L 193 REMARK 465 CYS L 194 REMARK 465 GLU L 195 REMARK 465 ALA L 196 REMARK 465 THR L 197 REMARK 465 HIS L 198 REMARK 465 LYS L 199 REMARK 465 THR L 200 REMARK 465 SER L 201 REMARK 465 THR L 202 REMARK 465 SER L 203 REMARK 465 PRO L 204 REMARK 465 ILE L 205 REMARK 465 VAL L 206 REMARK 465 LYS L 207 REMARK 465 SER L 208 REMARK 465 PHE L 209 REMARK 465 ASN L 210 REMARK 465 ARG L 211 REMARK 465 ASN L 212 REMARK 465 GLU L 213 REMARK 465 CYS L 214 REMARK 465 MET b -4 REMARK 465 ASP b -3 REMARK 465 ALA b -2 REMARK 465 MET b -1 REMARK 465 LYS b 0 REMARK 465 ARG b 1 REMARK 465 GLY b 2 REMARK 465 LEU b 3 REMARK 465 CYS b 4 REMARK 465 CYS b 5 REMARK 465 VAL b 6 REMARK 465 LEU b 7 REMARK 465 LEU b 8 REMARK 465 LEU b 9 REMARK 465 CYS b 10 REMARK 465 GLY b 11 REMARK 465 ALA b 12 REMARK 465 VAL b 13 REMARK 465 PHE b 14 REMARK 465 VAL b 15 REMARK 465 SER b 16 REMARK 465 PRO b 17 REMARK 465 SER b 18 REMARK 465 GLN b 19 REMARK 465 GLU b 20 REMARK 465 ILE b 21 REMARK 465 HIS b 22 REMARK 465 ALA b 23 REMARK 465 ARG b 24 REMARK 465 PHE b 25 REMARK 465 ARG b 26 REMARK 465 ARG b 27 REMARK 465 GLY b 28 REMARK 465 ALA b 29 REMARK 465 ARG b 30 REMARK 465 ALA b 31 REMARK 465 GLU b 32 REMARK 465 ALA b 60 REMARK 465 TYR b 61 REMARK 465 GLU b 62 REMARK 465 THR b 63 REMARK 465 SER b 144 REMARK 465 VAL b 145 REMARK 465 ASN b 146 REMARK 465 THR b 147 REMARK 465 THR b 148 REMARK 465 GLY b 149 REMARK 465 ASP b 403 REMARK 465 THR b 404 REMARK 465 ASP b 405 REMARK 465 SER b 406 REMARK 465 THR b 407 REMARK 465 GLN b 408 REMARK 465 GLU b 409 REMARK 465 ARG b 504 REMARK 465 VAL b 505 REMARK 465 VAL b 506 REMARK 465 GLU b 507 REMARK 465 ALA c 512 REMARK 465 VAL c 513 REMARK 465 GLY c 514 REMARK 465 ILE c 515 REMARK 465 GLY c 516 REMARK 465 ALA c 517 REMARK 465 VAL c 518 REMARK 465 GLY c 547 REMARK 465 ILE c 548 REMARK 465 VAL c 549 REMARK 465 GLN c 550 REMARK 465 PRO c 551 REMARK 465 GLN c 552 REMARK 465 ASN c 553 REMARK 465 ASN c 554 REMARK 465 LEU c 555 REMARK 465 LEU c 556 REMARK 465 ARG c 557 REMARK 465 ALA c 558 REMARK 465 PRO c 559 REMARK 465 GLU c 560 REMARK 465 ALA c 561 REMARK 465 GLN c 562 REMARK 465 ALA c 662 REMARK 465 LEU c 663 REMARK 465 ASP c 664 REMARK 465 ALA I 114 REMARK 465 SER I 115 REMARK 465 THR I 116 REMARK 465 THR I 117 REMARK 465 PRO I 118 REMARK 465 PRO I 119 REMARK 465 SER I 120 REMARK 465 VAL I 121 REMARK 465 TYR I 122 REMARK 465 PRO I 123 REMARK 465 LEU I 124 REMARK 465 ALA I 125 REMARK 465 PRO I 126 REMARK 465 GLY I 127 REMARK 465 SER I 128 REMARK 465 ALA I 129 REMARK 465 ALA I 130 REMARK 465 GLN I 131 REMARK 465 THR I 132 REMARK 465 ASN I 133 REMARK 465 SER I 134 REMARK 465 MET I 135 REMARK 465 VAL I 136 REMARK 465 THR I 137 REMARK 465 LEU I 138 REMARK 465 GLY I 139 REMARK 465 CYS I 140 REMARK 465 LEU I 141 REMARK 465 VAL I 142 REMARK 465 LYS I 143 REMARK 465 GLY I 144 REMARK 465 TYR I 145 REMARK 465 PHE I 146 REMARK 465 PRO I 147 REMARK 465 GLU I 148 REMARK 465 PRO I 149 REMARK 465 VAL I 150 REMARK 465 THR I 151 REMARK 465 VAL I 152 REMARK 465 THR I 153 REMARK 465 TRP I 154 REMARK 465 ASN I 155 REMARK 465 SER I 156 REMARK 465 GLY I 157 REMARK 465 SER I 158 REMARK 465 LEU I 159 REMARK 465 SER I 160 REMARK 465 SER I 161 REMARK 465 GLY I 162 REMARK 465 VAL I 163 REMARK 465 HIS I 164 REMARK 465 THR I 165 REMARK 465 PHE I 166 REMARK 465 PRO I 167 REMARK 465 ALA I 168 REMARK 465 VAL I 169 REMARK 465 LEU I 170 REMARK 465 GLN I 171 REMARK 465 SER I 172 REMARK 465 ASP I 173 REMARK 465 LEU I 174 REMARK 465 TYR I 175 REMARK 465 THR I 176 REMARK 465 LEU I 177 REMARK 465 SER I 178 REMARK 465 SER I 179 REMARK 465 SER I 180 REMARK 465 VAL I 181 REMARK 465 THR I 182 REMARK 465 VAL I 183 REMARK 465 PRO I 184 REMARK 465 SER I 185 REMARK 465 SER I 186 REMARK 465 THR I 187 REMARK 465 TRP I 188 REMARK 465 PRO I 189 REMARK 465 SER I 190 REMARK 465 GLU I 191 REMARK 465 THR I 192 REMARK 465 VAL I 193 REMARK 465 THR I 194 REMARK 465 CYS I 195 REMARK 465 ASN I 196 REMARK 465 VAL I 197 REMARK 465 ALA I 198 REMARK 465 HIS I 199 REMARK 465 PRO I 200 REMARK 465 ALA I 201 REMARK 465 SER I 202 REMARK 465 SER I 203 REMARK 465 THR I 204 REMARK 465 LYS I 205 REMARK 465 VAL I 206 REMARK 465 ASP I 207 REMARK 465 LYS I 208 REMARK 465 LYS I 209 REMARK 465 ILE I 210 REMARK 465 VAL I 211 REMARK 465 PRO I 212 REMARK 465 ARG I 213 REMARK 465 ASP I 214 REMARK 465 CYS I 215 REMARK 465 GLY I 216 REMARK 465 ARG M 108 REMARK 465 THR M 109 REMARK 465 ASP M 110 REMARK 465 ALA M 111 REMARK 465 ALA M 112 REMARK 465 PRO M 113 REMARK 465 THR M 114 REMARK 465 VAL M 115 REMARK 465 SER M 116 REMARK 465 ILE M 117 REMARK 465 PHE M 118 REMARK 465 PRO M 119 REMARK 465 PRO M 120 REMARK 465 SER M 121 REMARK 465 SER M 122 REMARK 465 GLU M 123 REMARK 465 GLN M 124 REMARK 465 LEU M 125 REMARK 465 THR M 126 REMARK 465 SER M 127 REMARK 465 GLY M 128 REMARK 465 GLY M 129 REMARK 465 ALA M 130 REMARK 465 SER M 131 REMARK 465 VAL M 132 REMARK 465 VAL M 133 REMARK 465 CYS M 134 REMARK 465 PHE M 135 REMARK 465 LEU M 136 REMARK 465 ASN M 137 REMARK 465 ASN M 138 REMARK 465 PHE M 139 REMARK 465 TYR M 140 REMARK 465 PRO M 141 REMARK 465 LYS M 142 REMARK 465 ASP M 143 REMARK 465 ILE M 144 REMARK 465 ASN M 145 REMARK 465 VAL M 146 REMARK 465 LYS M 147 REMARK 465 TRP M 148 REMARK 465 LYS M 149 REMARK 465 ILE M 150 REMARK 465 ASP M 151 REMARK 465 GLY M 152 REMARK 465 SER M 153 REMARK 465 GLU M 154 REMARK 465 ARG M 155 REMARK 465 GLN M 156 REMARK 465 ASN M 157 REMARK 465 GLY M 158 REMARK 465 VAL M 159 REMARK 465 LEU M 160 REMARK 465 ASN M 161 REMARK 465 SER M 162 REMARK 465 TRP M 163 REMARK 465 THR M 164 REMARK 465 ASP M 165 REMARK 465 GLN M 166 REMARK 465 ASP M 167 REMARK 465 SER M 168 REMARK 465 LYS M 169 REMARK 465 ASP M 170 REMARK 465 SER M 171 REMARK 465 THR M 172 REMARK 465 TYR M 173 REMARK 465 SER M 174 REMARK 465 MET M 175 REMARK 465 SER M 176 REMARK 465 SER M 177 REMARK 465 THR M 178 REMARK 465 LEU M 179 REMARK 465 THR M 180 REMARK 465 LEU M 181 REMARK 465 THR M 182 REMARK 465 LYS M 183 REMARK 465 ASP M 184 REMARK 465 GLU M 185 REMARK 465 TYR M 186 REMARK 465 GLU M 187 REMARK 465 ARG M 188 REMARK 465 HIS M 189 REMARK 465 ASN M 190 REMARK 465 SER M 191 REMARK 465 TYR M 192 REMARK 465 THR M 193 REMARK 465 CYS M 194 REMARK 465 GLU M 195 REMARK 465 ALA M 196 REMARK 465 THR M 197 REMARK 465 HIS M 198 REMARK 465 LYS M 199 REMARK 465 THR M 200 REMARK 465 SER M 201 REMARK 465 THR M 202 REMARK 465 SER M 203 REMARK 465 PRO M 204 REMARK 465 ILE M 205 REMARK 465 VAL M 206 REMARK 465 LYS M 207 REMARK 465 SER M 208 REMARK 465 PHE M 209 REMARK 465 ASN M 210 REMARK 465 ARG M 211 REMARK 465 ASN M 212 REMARK 465 GLU M 213 REMARK 465 CYS M 214 REMARK 465 MET d -4 REMARK 465 ASP d -3 REMARK 465 ALA d -2 REMARK 465 MET d -1 REMARK 465 LYS d 0 REMARK 465 ARG d 1 REMARK 465 GLY d 2 REMARK 465 LEU d 3 REMARK 465 CYS d 4 REMARK 465 CYS d 5 REMARK 465 VAL d 6 REMARK 465 LEU d 7 REMARK 465 LEU d 8 REMARK 465 LEU d 9 REMARK 465 CYS d 10 REMARK 465 GLY d 11 REMARK 465 ALA d 12 REMARK 465 VAL d 13 REMARK 465 PHE d 14 REMARK 465 VAL d 15 REMARK 465 SER d 16 REMARK 465 PRO d 17 REMARK 465 SER d 18 REMARK 465 GLN d 19 REMARK 465 GLU d 20 REMARK 465 ILE d 21 REMARK 465 HIS d 22 REMARK 465 ALA d 23 REMARK 465 ARG d 24 REMARK 465 PHE d 25 REMARK 465 ARG d 26 REMARK 465 ARG d 27 REMARK 465 GLY d 28 REMARK 465 ALA d 29 REMARK 465 ARG d 30 REMARK 465 ALA d 31 REMARK 465 GLU d 32 REMARK 465 ALA d 60 REMARK 465 TYR d 61 REMARK 465 GLU d 62 REMARK 465 THR d 63 REMARK 465 SER d 144 REMARK 465 VAL d 145 REMARK 465 ASN d 146 REMARK 465 THR d 147 REMARK 465 THR d 148 REMARK 465 GLY d 149 REMARK 465 ASP d 403 REMARK 465 THR d 404 REMARK 465 ASP d 405 REMARK 465 SER d 406 REMARK 465 THR d 407 REMARK 465 GLN d 408 REMARK 465 GLU d 409 REMARK 465 ARG d 504 REMARK 465 VAL d 505 REMARK 465 VAL d 506 REMARK 465 GLU d 507 REMARK 465 ALA e 512 REMARK 465 VAL e 513 REMARK 465 GLY e 514 REMARK 465 ILE e 515 REMARK 465 GLY e 516 REMARK 465 ALA e 517 REMARK 465 VAL e 518 REMARK 465 GLY e 547 REMARK 465 ILE e 548 REMARK 465 VAL e 549 REMARK 465 GLN e 550 REMARK 465 PRO e 551 REMARK 465 GLN e 552 REMARK 465 ASN e 553 REMARK 465 ASN e 554 REMARK 465 LEU e 555 REMARK 465 LEU e 556 REMARK 465 ARG e 557 REMARK 465 ALA e 558 REMARK 465 PRO e 559 REMARK 465 GLU e 560 REMARK 465 ALA e 561 REMARK 465 GLN e 562 REMARK 465 ALA e 662 REMARK 465 LEU e 663 REMARK 465 ASP e 664 REMARK 465 ALA J 114 REMARK 465 SER J 115 REMARK 465 THR J 116 REMARK 465 THR J 117 REMARK 465 PRO J 118 REMARK 465 PRO J 119 REMARK 465 SER J 120 REMARK 465 VAL J 121 REMARK 465 TYR J 122 REMARK 465 PRO J 123 REMARK 465 LEU J 124 REMARK 465 ALA J 125 REMARK 465 PRO J 126 REMARK 465 GLY J 127 REMARK 465 SER J 128 REMARK 465 ALA J 129 REMARK 465 ALA J 130 REMARK 465 GLN J 131 REMARK 465 THR J 132 REMARK 465 ASN J 133 REMARK 465 SER J 134 REMARK 465 MET J 135 REMARK 465 VAL J 136 REMARK 465 THR J 137 REMARK 465 LEU J 138 REMARK 465 GLY J 139 REMARK 465 CYS J 140 REMARK 465 LEU J 141 REMARK 465 VAL J 142 REMARK 465 LYS J 143 REMARK 465 GLY J 144 REMARK 465 TYR J 145 REMARK 465 PHE J 146 REMARK 465 PRO J 147 REMARK 465 GLU J 148 REMARK 465 PRO J 149 REMARK 465 VAL J 150 REMARK 465 THR J 151 REMARK 465 VAL J 152 REMARK 465 THR J 153 REMARK 465 TRP J 154 REMARK 465 ASN J 155 REMARK 465 SER J 156 REMARK 465 GLY J 157 REMARK 465 SER J 158 REMARK 465 LEU J 159 REMARK 465 SER J 160 REMARK 465 SER J 161 REMARK 465 GLY J 162 REMARK 465 VAL J 163 REMARK 465 HIS J 164 REMARK 465 THR J 165 REMARK 465 PHE J 166 REMARK 465 PRO J 167 REMARK 465 ALA J 168 REMARK 465 VAL J 169 REMARK 465 LEU J 170 REMARK 465 GLN J 171 REMARK 465 SER J 172 REMARK 465 ASP J 173 REMARK 465 LEU J 174 REMARK 465 TYR J 175 REMARK 465 THR J 176 REMARK 465 LEU J 177 REMARK 465 SER J 178 REMARK 465 SER J 179 REMARK 465 SER J 180 REMARK 465 VAL J 181 REMARK 465 THR J 182 REMARK 465 VAL J 183 REMARK 465 PRO J 184 REMARK 465 SER J 185 REMARK 465 SER J 186 REMARK 465 THR J 187 REMARK 465 TRP J 188 REMARK 465 PRO J 189 REMARK 465 SER J 190 REMARK 465 GLU J 191 REMARK 465 THR J 192 REMARK 465 VAL J 193 REMARK 465 THR J 194 REMARK 465 CYS J 195 REMARK 465 ASN J 196 REMARK 465 VAL J 197 REMARK 465 ALA J 198 REMARK 465 HIS J 199 REMARK 465 PRO J 200 REMARK 465 ALA J 201 REMARK 465 SER J 202 REMARK 465 SER J 203 REMARK 465 THR J 204 REMARK 465 LYS J 205 REMARK 465 VAL J 206 REMARK 465 ASP J 207 REMARK 465 LYS J 208 REMARK 465 LYS J 209 REMARK 465 ILE J 210 REMARK 465 VAL J 211 REMARK 465 PRO J 212 REMARK 465 ARG J 213 REMARK 465 ASP J 214 REMARK 465 CYS J 215 REMARK 465 GLY J 216 REMARK 465 ARG N 108 REMARK 465 THR N 109 REMARK 465 ASP N 110 REMARK 465 ALA N 111 REMARK 465 ALA N 112 REMARK 465 PRO N 113 REMARK 465 THR N 114 REMARK 465 VAL N 115 REMARK 465 SER N 116 REMARK 465 ILE N 117 REMARK 465 PHE N 118 REMARK 465 PRO N 119 REMARK 465 PRO N 120 REMARK 465 SER N 121 REMARK 465 SER N 122 REMARK 465 GLU N 123 REMARK 465 GLN N 124 REMARK 465 LEU N 125 REMARK 465 THR N 126 REMARK 465 SER N 127 REMARK 465 GLY N 128 REMARK 465 GLY N 129 REMARK 465 ALA N 130 REMARK 465 SER N 131 REMARK 465 VAL N 132 REMARK 465 VAL N 133 REMARK 465 CYS N 134 REMARK 465 PHE N 135 REMARK 465 LEU N 136 REMARK 465 ASN N 137 REMARK 465 ASN N 138 REMARK 465 PHE N 139 REMARK 465 TYR N 140 REMARK 465 PRO N 141 REMARK 465 LYS N 142 REMARK 465 ASP N 143 REMARK 465 ILE N 144 REMARK 465 ASN N 145 REMARK 465 VAL N 146 REMARK 465 LYS N 147 REMARK 465 TRP N 148 REMARK 465 LYS N 149 REMARK 465 ILE N 150 REMARK 465 ASP N 151 REMARK 465 GLY N 152 REMARK 465 SER N 153 REMARK 465 GLU N 154 REMARK 465 ARG N 155 REMARK 465 GLN N 156 REMARK 465 ASN N 157 REMARK 465 GLY N 158 REMARK 465 VAL N 159 REMARK 465 LEU N 160 REMARK 465 ASN N 161 REMARK 465 SER N 162 REMARK 465 TRP N 163 REMARK 465 THR N 164 REMARK 465 ASP N 165 REMARK 465 GLN N 166 REMARK 465 ASP N 167 REMARK 465 SER N 168 REMARK 465 LYS N 169 REMARK 465 ASP N 170 REMARK 465 SER N 171 REMARK 465 THR N 172 REMARK 465 TYR N 173 REMARK 465 SER N 174 REMARK 465 MET N 175 REMARK 465 SER N 176 REMARK 465 SER N 177 REMARK 465 THR N 178 REMARK 465 LEU N 179 REMARK 465 THR N 180 REMARK 465 LEU N 181 REMARK 465 THR N 182 REMARK 465 LYS N 183 REMARK 465 ASP N 184 REMARK 465 GLU N 185 REMARK 465 TYR N 186 REMARK 465 GLU N 187 REMARK 465 ARG N 188 REMARK 465 HIS N 189 REMARK 465 ASN N 190 REMARK 465 SER N 191 REMARK 465 TYR N 192 REMARK 465 THR N 193 REMARK 465 CYS N 194 REMARK 465 GLU N 195 REMARK 465 ALA N 196 REMARK 465 THR N 197 REMARK 465 HIS N 198 REMARK 465 LYS N 199 REMARK 465 THR N 200 REMARK 465 SER N 201 REMARK 465 THR N 202 REMARK 465 SER N 203 REMARK 465 PRO N 204 REMARK 465 ILE N 205 REMARK 465 VAL N 206 REMARK 465 LYS N 207 REMARK 465 SER N 208 REMARK 465 PHE N 209 REMARK 465 ASN N 210 REMARK 465 ARG N 211 REMARK 465 ASN N 212 REMARK 465 GLU N 213 REMARK 465 CYS N 214 REMARK 465 MET f -4 REMARK 465 ASP f -3 REMARK 465 ALA f -2 REMARK 465 MET f -1 REMARK 465 LYS f 0 REMARK 465 ARG f 1 REMARK 465 GLY f 2 REMARK 465 LEU f 3 REMARK 465 CYS f 4 REMARK 465 CYS f 5 REMARK 465 VAL f 6 REMARK 465 LEU f 7 REMARK 465 LEU f 8 REMARK 465 LEU f 9 REMARK 465 CYS f 10 REMARK 465 GLY f 11 REMARK 465 ALA f 12 REMARK 465 VAL f 13 REMARK 465 PHE f 14 REMARK 465 VAL f 15 REMARK 465 SER f 16 REMARK 465 PRO f 17 REMARK 465 SER f 18 REMARK 465 GLN f 19 REMARK 465 GLU f 20 REMARK 465 ILE f 21 REMARK 465 HIS f 22 REMARK 465 ALA f 23 REMARK 465 ARG f 24 REMARK 465 PHE f 25 REMARK 465 ARG f 26 REMARK 465 ARG f 27 REMARK 465 GLY f 28 REMARK 465 ALA f 29 REMARK 465 ARG f 30 REMARK 465 ALA f 31 REMARK 465 GLU f 32 REMARK 465 ALA f 60 REMARK 465 TYR f 61 REMARK 465 GLU f 62 REMARK 465 THR f 63 REMARK 465 SER f 144 REMARK 465 VAL f 145 REMARK 465 ASN f 146 REMARK 465 THR f 147 REMARK 465 THR f 148 REMARK 465 GLY f 149 REMARK 465 ASP f 403 REMARK 465 THR f 404 REMARK 465 ASP f 405 REMARK 465 SER f 406 REMARK 465 THR f 407 REMARK 465 GLN f 408 REMARK 465 GLU f 409 REMARK 465 ARG f 504 REMARK 465 VAL f 505 REMARK 465 VAL f 506 REMARK 465 GLU f 507 REMARK 465 ALA g 512 REMARK 465 VAL g 513 REMARK 465 GLY g 514 REMARK 465 ILE g 515 REMARK 465 GLY g 516 REMARK 465 ALA g 517 REMARK 465 VAL g 518 REMARK 465 GLY g 547 REMARK 465 ILE g 548 REMARK 465 VAL g 549 REMARK 465 GLN g 550 REMARK 465 PRO g 551 REMARK 465 GLN g 552 REMARK 465 ASN g 553 REMARK 465 ASN g 554 REMARK 465 LEU g 555 REMARK 465 LEU g 556 REMARK 465 ARG g 557 REMARK 465 ALA g 558 REMARK 465 PRO g 559 REMARK 465 GLU g 560 REMARK 465 ALA g 561 REMARK 465 GLN g 562 REMARK 465 ALA g 662 REMARK 465 LEU g 663 REMARK 465 ASP g 664 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 SER L 30 -97.39 57.27 REMARK 500 TYR L 49 -61.00 -92.05 REMARK 500 SER L 76 -121.19 58.66 REMARK 500 TYR L 91 -169.01 -116.58 REMARK 500 ASN b 185 -8.41 76.67 REMARK 500 SER b 189 -169.51 -167.72 REMARK 500 GLU b 190 60.29 60.06 REMARK 500 GLN b 258 -11.53 72.86 REMARK 500 SER b 274 140.05 -170.48 REMARK 500 CYS b 378 53.59 -93.18 REMARK 500 SER b 393 167.45 179.09 REMARK 500 TRP b 427 31.98 -98.90 REMARK 500 SER M 30 -97.17 57.17 REMARK 500 SER M 31 12.79 -141.46 REMARK 500 TYR M 49 -62.32 -91.49 REMARK 500 SER M 67 149.36 -173.95 REMARK 500 SER M 77 44.53 36.15 REMARK 500 TYR M 91 -169.27 -124.42 REMARK 500 ASP M 92 34.91 70.35 REMARK 500 SER d 174 148.31 -171.95 REMARK 500 ASN d 185 -9.30 76.77 REMARK 500 GLU d 190 63.90 61.84 REMARK 500 GLN d 258 -11.60 73.39 REMARK 500 SER d 274 140.53 -170.57 REMARK 500 PHE d 376 -165.66 -160.87 REMARK 500 CYS d 378 50.93 -91.13 REMARK 500 SER d 393 165.38 179.67 REMARK 500 ASP d 461 -7.19 73.74 REMARK 500 SER e 618 -179.62 -68.77 REMARK 500 SER N 30 -96.78 58.39 REMARK 500 SER N 31 10.78 -141.35 REMARK 500 SER N 52 24.40 -140.12 REMARK 500 SER N 77 -170.73 72.02 REMARK 500 ASP N 92 41.95 72.03 REMARK 500 SER f 174 146.62 -171.16 REMARK 500 ASN f 185 -6.75 75.69 REMARK 500 GLN f 188 -101.90 65.48 REMARK 500 GLN f 258 -11.48 73.31 REMARK 500 SER f 274 139.96 -170.65 REMARK 500 PHE f 376 -166.37 -163.78 REMARK 500 CYS f 378 50.34 -91.18 REMARK 500 SER f 393 165.57 179.86 REMARK 500 ASP f 461 -0.27 67.01 REMARK 500 REMARK 500 REMARK: NULL REMARK 610 REMARK 610 MISSING HETEROATOM REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 610 I=INSERTION CODE): REMARK 610 M RES C SSEQI REMARK 610 NAG i 1 REMARK 610 NAG j 1 REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-70663 RELATED DB: EMDB REMARK 900 CRYO-EM STRUCTURE OF VACCINE-ELICITED ANTIBODY T3_NB_G05 IN COMPLEX REMARK 900 WITH HIV ENV TRIMER Q23-APEX-GT1.N187S DBREF 9OOG H 1 216 PDB 9OOG 9OOG 1 216 DBREF 9OOG L 1 214 PDB 9OOG 9OOG 1 214 DBREF 9OOG b -4 507 PDB 9OOG 9OOG -4 507 DBREF 9OOG c 512 664 PDB 9OOG 9OOG 512 664 DBREF 9OOG I 1 216 PDB 9OOG 9OOG 1 216 DBREF 9OOG M 1 214 PDB 9OOG 9OOG 1 214 DBREF 9OOG d -4 507 PDB 9OOG 9OOG -4 507 DBREF 9OOG e 512 664 PDB 9OOG 9OOG 512 664 DBREF 9OOG J 1 216 PDB 9OOG 9OOG 1 216 DBREF 9OOG N 1 214 PDB 9OOG 9OOG 1 214 DBREF 9OOG f -4 507 PDB 9OOG 9OOG -4 507 DBREF 9OOG g 512 664 PDB 9OOG 9OOG 512 664 SEQRES 1 H 235 GLU VAL HIS LEU VAL GLU SER GLY GLY GLY LEU ALA THR SEQRES 2 H 235 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 H 235 PHE THR PHE SER ASN TYR TRP MET ASN TRP VAL ARG GLN SEQRES 4 H 235 THR PRO GLY LYS GLY LEU GLU TRP ILE ALA SER ILE ASN SEQRES 5 H 235 SER ALA GLY GLY ALA ARG ASP TYR ALA ASP SER VAL MET SEQRES 6 H 235 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 H 235 LEU SER LEU LYS MET ASN SER LEU ARG THR GLU ASP THR SEQRES 8 H 235 ALA VAL TYR TYR CYS ALA LYS VAL ASP GLU ASP ASP TYR SEQRES 9 H 235 GLY TYR PHE SER ILE VAL PRO GLY ASP LEU LYS LYS TYR SEQRES 10 H 235 TYR PHE LYS TYR TRP GLY GLN GLY VAL GLN VAL THR VAL SEQRES 11 H 235 SER SER ALA SER THR THR PRO PRO SER VAL TYR PRO LEU SEQRES 12 H 235 ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL THR SEQRES 13 H 235 LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO VAL SEQRES 14 H 235 THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY VAL SEQRES 15 H 235 HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR THR SEQRES 16 H 235 LEU SER SER SER VAL THR VAL PRO SER SER THR TRP PRO SEQRES 17 H 235 SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SER SEQRES 18 H 235 SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP CYS SEQRES 19 H 235 GLY SEQRES 1 L 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 L 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS GLN ALA SER SEQRES 3 L 214 GLN GLY ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 L 214 PRO GLY LYS ALA PRO LYS SER LEU ILE TYR LYS ALA SER SEQRES 5 L 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 L 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 L 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 L 214 ASP SER ALA PRO PHE SER PHE GLY GLN GLY THR GLU VAL SEQRES 9 L 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 L 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 L 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 L 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 L 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 L 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 L 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 L 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 L 214 PHE ASN ARG ASN GLU CYS SEQRES 1 b 503 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 b 503 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 b 503 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU ASN LEU SEQRES 4 b 503 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP ARG ASP SEQRES 5 b 503 ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA LYS ALA SEQRES 6 b 503 TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR HIS ALA SEQRES 7 b 503 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE HIS LEU SEQRES 8 b 503 ASP ASN VAL THR GLU LYS PHE ASN MET TRP LYS ASN ASN SEQRES 9 b 503 MET VAL GLU GLN MET HIS THR ASP ILE ILE SER LEU TRP SEQRES 10 b 503 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 b 503 CYS VAL THR LEU HIS CYS THR ASN VAL THR SER VAL ASN SEQRES 12 b 503 THR THR GLY ASP ARG GLU GLU LEU LYS ASN CYS SER PHE SEQRES 13 b 503 ASN MET THR THR GLU LEU ARG ASP LYS ARG GLN LYS VAL SEQRES 14 b 503 TYR SER LEU PHE TYR ARG LEU ASP ILE VAL PRO ILE ASN SEQRES 15 b 503 GLU SER GLN GLY SER GLU TYR ARG LEU ILE ASN CYS ASN SEQRES 16 b 503 THR SER ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE SEQRES 17 b 503 GLU PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE SEQRES 18 b 503 ALA ILE LEU LYS CYS LYS ASP GLU GLY PHE ASN GLY THR SEQRES 19 b 503 GLY LEU CYS LYS ASN VAL SER THR VAL GLN CYS THR HIS SEQRES 20 b 503 GLY ILE LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN SEQRES 21 b 503 GLY SER LEU ALA GLU LYS ASN ILE THR ILE ARG SER GLU SEQRES 22 b 503 ASN ILE THR ASN ASN ALA LYS ILE ILE ILE VAL GLN LEU SEQRES 23 b 503 VAL GLN PRO VAL THR ILE LYS CYS ILE ARG PRO ASN ASN SEQRES 24 b 503 TYR THR ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA SEQRES 25 b 503 PHE TYR ALA MET GLY ASP ILE ILE GLY ASP ILE ARG GLN SEQRES 26 b 503 ALA HIS CYS ASN VAL SER ARG SER ARG TRP ASN LYS THR SEQRES 27 b 503 LEU GLN GLU VAL ALA GLU LYS LEU ARG THR TYR PHE GLY SEQRES 28 b 503 ASN LYS THR ILE ILE PHE ALA ASN SER SER GLY GLY ASP SEQRES 29 b 503 LEU GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU SEQRES 30 b 503 PHE PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR SEQRES 31 b 503 TRP TYR VAL ASN SER THR TRP ASN ASP THR ASP SER THR SEQRES 32 b 503 GLN GLU SER ASN ASP THR ILE THR LEU PRO CYS ARG ILE SEQRES 33 b 503 LYS GLN ILE ILE ASN MET TRP GLN ARG ALA GLY GLN CYS SEQRES 34 b 503 MET TYR ALA PRO PRO ILE PRO GLY VAL ILE LYS CYS GLU SEQRES 35 b 503 SER ASN ILE THR GLY LEU LEU LEU THR ARG ASP GLY GLY SEQRES 36 b 503 LYS ASP ASN ASN VAL ASN GLU THR PHE ARG PRO GLY GLY SEQRES 37 b 503 GLY ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS SEQRES 38 b 503 TYR LYS VAL VAL GLU ILE GLU PRO LEU GLY VAL ALA PRO SEQRES 39 b 503 THR ARG CYS LYS ARG ARG VAL VAL GLU SEQRES 1 c 153 ALA VAL GLY ILE GLY ALA VAL ARG ARG GLY PHE LEU GLY SEQRES 2 c 153 ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR LEU SEQRES 3 c 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 c 153 PRO GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 c 153 HIS LEU LEU LYS LEU GLY VAL TRP GLY ILE LYS GLN LEU SEQRES 6 c 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 c 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 c 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 c 153 ASN LYS SER LEU ASP GLU ILE TRP ASN ASN MET THR TRP SEQRES 10 c 153 LEU GLN TRP ASP LYS GLU ILE GLY ASN TYR THR GLN LEU SEQRES 11 c 153 ILE TYR ARG LEU ILE GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 c 153 LYS ASN GLU LYS GLU LEU LEU ALA LEU ASP SEQRES 1 I 235 GLU VAL HIS LEU VAL GLU SER GLY GLY GLY LEU ALA THR SEQRES 2 I 235 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 I 235 PHE THR PHE SER ASN TYR TRP MET ASN TRP VAL ARG GLN SEQRES 4 I 235 THR PRO GLY LYS GLY LEU GLU TRP ILE ALA SER ILE ASN SEQRES 5 I 235 SER ALA GLY GLY ALA ARG ASP TYR ALA ASP SER VAL MET SEQRES 6 I 235 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 I 235 LEU SER LEU LYS MET ASN SER LEU ARG THR GLU ASP THR SEQRES 8 I 235 ALA VAL TYR TYR CYS ALA LYS VAL ASP GLU ASP ASP TYR SEQRES 9 I 235 GLY TYR PHE SER ILE VAL PRO GLY ASP LEU LYS LYS TYR SEQRES 10 I 235 TYR PHE LYS TYR TRP GLY GLN GLY VAL GLN VAL THR VAL SEQRES 11 I 235 SER SER ALA SER THR THR PRO PRO SER VAL TYR PRO LEU SEQRES 12 I 235 ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL THR SEQRES 13 I 235 LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO VAL SEQRES 14 I 235 THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY VAL SEQRES 15 I 235 HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR THR SEQRES 16 I 235 LEU SER SER SER VAL THR VAL PRO SER SER THR TRP PRO SEQRES 17 I 235 SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SER SEQRES 18 I 235 SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP CYS SEQRES 19 I 235 GLY SEQRES 1 M 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 M 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS GLN ALA SER SEQRES 3 M 214 GLN GLY ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 M 214 PRO GLY LYS ALA PRO LYS SER LEU ILE TYR LYS ALA SER SEQRES 5 M 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 M 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 M 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 M 214 ASP SER ALA PRO PHE SER PHE GLY GLN GLY THR GLU VAL SEQRES 9 M 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 M 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 M 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 M 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 M 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 M 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 M 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 M 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 M 214 PHE ASN ARG ASN GLU CYS SEQRES 1 d 503 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 d 503 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 d 503 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU ASN LEU SEQRES 4 d 503 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP ARG ASP SEQRES 5 d 503 ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA LYS ALA SEQRES 6 d 503 TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR HIS ALA SEQRES 7 d 503 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE HIS LEU SEQRES 8 d 503 ASP ASN VAL THR GLU LYS PHE ASN MET TRP LYS ASN ASN SEQRES 9 d 503 MET VAL GLU GLN MET HIS THR ASP ILE ILE SER LEU TRP SEQRES 10 d 503 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 d 503 CYS VAL THR LEU HIS CYS THR ASN VAL THR SER VAL ASN SEQRES 12 d 503 THR THR GLY ASP ARG GLU GLU LEU LYS ASN CYS SER PHE SEQRES 13 d 503 ASN MET THR THR GLU LEU ARG ASP LYS ARG GLN LYS VAL SEQRES 14 d 503 TYR SER LEU PHE TYR ARG LEU ASP ILE VAL PRO ILE ASN SEQRES 15 d 503 GLU SER GLN GLY SER GLU TYR ARG LEU ILE ASN CYS ASN SEQRES 16 d 503 THR SER ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE SEQRES 17 d 503 GLU PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE SEQRES 18 d 503 ALA ILE LEU LYS CYS LYS ASP GLU GLY PHE ASN GLY THR SEQRES 19 d 503 GLY LEU CYS LYS ASN VAL SER THR VAL GLN CYS THR HIS SEQRES 20 d 503 GLY ILE LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN SEQRES 21 d 503 GLY SER LEU ALA GLU LYS ASN ILE THR ILE ARG SER GLU SEQRES 22 d 503 ASN ILE THR ASN ASN ALA LYS ILE ILE ILE VAL GLN LEU SEQRES 23 d 503 VAL GLN PRO VAL THR ILE LYS CYS ILE ARG PRO ASN ASN SEQRES 24 d 503 TYR THR ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA SEQRES 25 d 503 PHE TYR ALA MET GLY ASP ILE ILE GLY ASP ILE ARG GLN SEQRES 26 d 503 ALA HIS CYS ASN VAL SER ARG SER ARG TRP ASN LYS THR SEQRES 27 d 503 LEU GLN GLU VAL ALA GLU LYS LEU ARG THR TYR PHE GLY SEQRES 28 d 503 ASN LYS THR ILE ILE PHE ALA ASN SER SER GLY GLY ASP SEQRES 29 d 503 LEU GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU SEQRES 30 d 503 PHE PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR SEQRES 31 d 503 TRP TYR VAL ASN SER THR TRP ASN ASP THR ASP SER THR SEQRES 32 d 503 GLN GLU SER ASN ASP THR ILE THR LEU PRO CYS ARG ILE SEQRES 33 d 503 LYS GLN ILE ILE ASN MET TRP GLN ARG ALA GLY GLN CYS SEQRES 34 d 503 MET TYR ALA PRO PRO ILE PRO GLY VAL ILE LYS CYS GLU SEQRES 35 d 503 SER ASN ILE THR GLY LEU LEU LEU THR ARG ASP GLY GLY SEQRES 36 d 503 LYS ASP ASN ASN VAL ASN GLU THR PHE ARG PRO GLY GLY SEQRES 37 d 503 GLY ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS SEQRES 38 d 503 TYR LYS VAL VAL GLU ILE GLU PRO LEU GLY VAL ALA PRO SEQRES 39 d 503 THR ARG CYS LYS ARG ARG VAL VAL GLU SEQRES 1 e 153 ALA VAL GLY ILE GLY ALA VAL ARG ARG GLY PHE LEU GLY SEQRES 2 e 153 ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR LEU SEQRES 3 e 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 e 153 PRO GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 e 153 HIS LEU LEU LYS LEU GLY VAL TRP GLY ILE LYS GLN LEU SEQRES 6 e 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 e 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 e 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 e 153 ASN LYS SER LEU ASP GLU ILE TRP ASN ASN MET THR TRP SEQRES 10 e 153 LEU GLN TRP ASP LYS GLU ILE GLY ASN TYR THR GLN LEU SEQRES 11 e 153 ILE TYR ARG LEU ILE GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 e 153 LYS ASN GLU LYS GLU LEU LEU ALA LEU ASP SEQRES 1 J 235 GLU VAL HIS LEU VAL GLU SER GLY GLY GLY LEU ALA THR SEQRES 2 J 235 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 J 235 PHE THR PHE SER ASN TYR TRP MET ASN TRP VAL ARG GLN SEQRES 4 J 235 THR PRO GLY LYS GLY LEU GLU TRP ILE ALA SER ILE ASN SEQRES 5 J 235 SER ALA GLY GLY ALA ARG ASP TYR ALA ASP SER VAL MET SEQRES 6 J 235 GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN THR SEQRES 7 J 235 LEU SER LEU LYS MET ASN SER LEU ARG THR GLU ASP THR SEQRES 8 J 235 ALA VAL TYR TYR CYS ALA LYS VAL ASP GLU ASP ASP TYR SEQRES 9 J 235 GLY TYR PHE SER ILE VAL PRO GLY ASP LEU LYS LYS TYR SEQRES 10 J 235 TYR PHE LYS TYR TRP GLY GLN GLY VAL GLN VAL THR VAL SEQRES 11 J 235 SER SER ALA SER THR THR PRO PRO SER VAL TYR PRO LEU SEQRES 12 J 235 ALA PRO GLY SER ALA ALA GLN THR ASN SER MET VAL THR SEQRES 13 J 235 LEU GLY CYS LEU VAL LYS GLY TYR PHE PRO GLU PRO VAL SEQRES 14 J 235 THR VAL THR TRP ASN SER GLY SER LEU SER SER GLY VAL SEQRES 15 J 235 HIS THR PHE PRO ALA VAL LEU GLN SER ASP LEU TYR THR SEQRES 16 J 235 LEU SER SER SER VAL THR VAL PRO SER SER THR TRP PRO SEQRES 17 J 235 SER GLU THR VAL THR CYS ASN VAL ALA HIS PRO ALA SER SEQRES 18 J 235 SER THR LYS VAL ASP LYS LYS ILE VAL PRO ARG ASP CYS SEQRES 19 J 235 GLY SEQRES 1 N 214 ASP ILE GLN MET THR GLN SER PRO SER SER LEU SER ALA SEQRES 2 N 214 SER VAL GLY ASP ARG VAL THR ILE THR CYS GLN ALA SER SEQRES 3 N 214 GLN GLY ILE SER SER TRP LEU ALA TRP TYR GLN GLN LYS SEQRES 4 N 214 PRO GLY LYS ALA PRO LYS SER LEU ILE TYR LYS ALA SER SEQRES 5 N 214 SER LEU GLU SER GLY VAL PRO SER ARG PHE SER GLY SER SEQRES 6 N 214 GLY SER GLY THR ASP PHE THR LEU THR ILE SER SER LEU SEQRES 7 N 214 GLN PRO GLU ASP PHE ALA THR TYR TYR CYS GLN GLN TYR SEQRES 8 N 214 ASP SER ALA PRO PHE SER PHE GLY GLN GLY THR GLU VAL SEQRES 9 N 214 GLU ILE LYS ARG THR ASP ALA ALA PRO THR VAL SER ILE SEQRES 10 N 214 PHE PRO PRO SER SER GLU GLN LEU THR SER GLY GLY ALA SEQRES 11 N 214 SER VAL VAL CYS PHE LEU ASN ASN PHE TYR PRO LYS ASP SEQRES 12 N 214 ILE ASN VAL LYS TRP LYS ILE ASP GLY SER GLU ARG GLN SEQRES 13 N 214 ASN GLY VAL LEU ASN SER TRP THR ASP GLN ASP SER LYS SEQRES 14 N 214 ASP SER THR TYR SER MET SER SER THR LEU THR LEU THR SEQRES 15 N 214 LYS ASP GLU TYR GLU ARG HIS ASN SER TYR THR CYS GLU SEQRES 16 N 214 ALA THR HIS LYS THR SER THR SER PRO ILE VAL LYS SER SEQRES 17 N 214 PHE ASN ARG ASN GLU CYS SEQRES 1 f 503 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 f 503 LEU CYS GLY ALA VAL PHE VAL SER PRO SER GLN GLU ILE SEQRES 3 f 503 HIS ALA ARG PHE ARG ARG GLY ALA ARG ALA GLU ASN LEU SEQRES 4 f 503 TRP VAL THR VAL TYR TYR GLY VAL PRO VAL TRP ARG ASP SEQRES 5 f 503 ALA GLU THR THR LEU PHE CYS ALA SER ASP ALA LYS ALA SEQRES 6 f 503 TYR GLU THR GLU LYS HIS ASN VAL TRP ALA THR HIS ALA SEQRES 7 f 503 CYS VAL PRO THR ASP PRO ASN PRO GLN GLU ILE HIS LEU SEQRES 8 f 503 ASP ASN VAL THR GLU LYS PHE ASN MET TRP LYS ASN ASN SEQRES 9 f 503 MET VAL GLU GLN MET HIS THR ASP ILE ILE SER LEU TRP SEQRES 10 f 503 ASP GLN SER LEU LYS PRO CYS VAL LYS LEU THR PRO LEU SEQRES 11 f 503 CYS VAL THR LEU HIS CYS THR ASN VAL THR SER VAL ASN SEQRES 12 f 503 THR THR GLY ASP ARG GLU GLU LEU LYS ASN CYS SER PHE SEQRES 13 f 503 ASN MET THR THR GLU LEU ARG ASP LYS ARG GLN LYS VAL SEQRES 14 f 503 TYR SER LEU PHE TYR ARG LEU ASP ILE VAL PRO ILE ASN SEQRES 15 f 503 GLU SER GLN GLY SER GLU TYR ARG LEU ILE ASN CYS ASN SEQRES 16 f 503 THR SER ALA CYS THR GLN ALA CYS PRO LYS VAL SER PHE SEQRES 17 f 503 GLU PRO ILE PRO ILE HIS TYR CYS ALA PRO ALA GLY PHE SEQRES 18 f 503 ALA ILE LEU LYS CYS LYS ASP GLU GLY PHE ASN GLY THR SEQRES 19 f 503 GLY LEU CYS LYS ASN VAL SER THR VAL GLN CYS THR HIS SEQRES 20 f 503 GLY ILE LYS PRO VAL VAL SER THR GLN LEU LEU LEU ASN SEQRES 21 f 503 GLY SER LEU ALA GLU LYS ASN ILE THR ILE ARG SER GLU SEQRES 22 f 503 ASN ILE THR ASN ASN ALA LYS ILE ILE ILE VAL GLN LEU SEQRES 23 f 503 VAL GLN PRO VAL THR ILE LYS CYS ILE ARG PRO ASN ASN SEQRES 24 f 503 TYR THR ARG LYS SER ILE ARG ILE GLY PRO GLY GLN ALA SEQRES 25 f 503 PHE TYR ALA MET GLY ASP ILE ILE GLY ASP ILE ARG GLN SEQRES 26 f 503 ALA HIS CYS ASN VAL SER ARG SER ARG TRP ASN LYS THR SEQRES 27 f 503 LEU GLN GLU VAL ALA GLU LYS LEU ARG THR TYR PHE GLY SEQRES 28 f 503 ASN LYS THR ILE ILE PHE ALA ASN SER SER GLY GLY ASP SEQRES 29 f 503 LEU GLU ILE THR THR HIS SER PHE ASN CYS GLY GLY GLU SEQRES 30 f 503 PHE PHE TYR CYS ASN THR SER GLY LEU PHE ASN SER THR SEQRES 31 f 503 TRP TYR VAL ASN SER THR TRP ASN ASP THR ASP SER THR SEQRES 32 f 503 GLN GLU SER ASN ASP THR ILE THR LEU PRO CYS ARG ILE SEQRES 33 f 503 LYS GLN ILE ILE ASN MET TRP GLN ARG ALA GLY GLN CYS SEQRES 34 f 503 MET TYR ALA PRO PRO ILE PRO GLY VAL ILE LYS CYS GLU SEQRES 35 f 503 SER ASN ILE THR GLY LEU LEU LEU THR ARG ASP GLY GLY SEQRES 36 f 503 LYS ASP ASN ASN VAL ASN GLU THR PHE ARG PRO GLY GLY SEQRES 37 f 503 GLY ASP MET ARG ASP ASN TRP ARG SER GLU LEU TYR LYS SEQRES 38 f 503 TYR LYS VAL VAL GLU ILE GLU PRO LEU GLY VAL ALA PRO SEQRES 39 f 503 THR ARG CYS LYS ARG ARG VAL VAL GLU SEQRES 1 g 153 ALA VAL GLY ILE GLY ALA VAL ARG ARG GLY PHE LEU GLY SEQRES 2 g 153 ALA ALA GLY SER THR MET GLY ALA ALA SER ILE THR LEU SEQRES 3 g 153 THR VAL GLN ALA ARG GLN LEU LEU SER GLY ILE VAL GLN SEQRES 4 g 153 PRO GLN ASN ASN LEU LEU ARG ALA PRO GLU ALA GLN GLN SEQRES 5 g 153 HIS LEU LEU LYS LEU GLY VAL TRP GLY ILE LYS GLN LEU SEQRES 6 g 153 GLN ALA ARG VAL LEU ALA VAL GLU ARG TYR LEU ARG ASP SEQRES 7 g 153 GLN GLN LEU LEU GLY ILE TRP GLY CYS SER GLY LYS LEU SEQRES 8 g 153 ILE CYS CYS THR ASN VAL PRO TRP ASN SER SER TRP SER SEQRES 9 g 153 ASN LYS SER LEU ASP GLU ILE TRP ASN ASN MET THR TRP SEQRES 10 g 153 LEU GLN TRP ASP LYS GLU ILE GLY ASN TYR THR GLN LEU SEQRES 11 g 153 ILE TYR ARG LEU ILE GLU GLU SER GLN ASN GLN GLN GLU SEQRES 12 g 153 LYS ASN GLU LYS GLU LEU LEU ALA LEU ASP HET NAG A 1 14 HET NAG A 2 14 HET NAG B 1 14 HET NAG B 2 14 HET BMA B 3 11 HET NAG C 1 14 HET NAG C 2 14 HET BMA C 3 11 HET MAN C 4 11 HET MAN C 5 11 HET NAG D 1 14 HET NAG D 2 14 HET BMA D 3 11 HET MAN D 4 11 HET MAN D 5 11 HET NAG E 1 14 HET NAG E 2 14 HET BMA E 3 11 HET MAN E 4 11 HET MAN E 5 11 HET MAN E 6 11 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG K 1 14 HET NAG K 2 14 HET BMA K 3 11 HET NAG O 1 14 HET NAG O 2 14 HET NAG P 1 14 HET NAG P 2 14 HET NAG Q 1 14 HET NAG Q 2 14 HET NAG R 1 14 HET NAG R 2 14 HET NAG S 1 14 HET NAG S 2 14 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET NAG U 1 14 HET NAG U 2 14 HET BMA U 3 11 HET MAN U 4 11 HET MAN U 5 11 HET NAG V 1 14 HET NAG V 2 14 HET BMA V 3 11 HET MAN V 4 11 HET MAN V 5 11 HET NAG W 1 14 HET NAG W 2 14 HET BMA W 3 11 HET MAN W 4 11 HET MAN W 5 11 HET MAN W 6 11 HET NAG X 1 14 HET NAG X 2 14 HET NAG Y 1 14 HET NAG Y 2 14 HET NAG Z 1 14 HET NAG Z 2 14 HET NAG a 1 14 HET NAG a 2 14 HET NAG h 1 14 HET NAG h 2 14 HET NAG i 1 14 HET NAG i 2 14 HET NAG j 1 14 HET NAG j 2 14 HET NAG k 1 14 HET NAG k 2 14 HET NAG l 1 14 HET NAG l 2 14 HET NAG m 1 14 HET NAG m 2 14 HET NAG n 1 14 HET NAG n 2 14 HET BMA n 3 11 HET NAG o 1 14 HET NAG o 2 14 HET BMA o 3 11 HET MAN o 4 11 HET MAN o 5 11 HET NAG p 1 14 HET NAG p 2 14 HET BMA p 3 11 HET MAN p 4 11 HET MAN p 5 11 HET NAG q 1 14 HET NAG q 2 14 HET BMA q 3 11 HET MAN q 4 11 HET MAN q 5 11 HET MAN q 6 11 HET NAG r 1 14 HET NAG r 2 14 HET NAG s 1 14 HET NAG s 2 14 HET NAG t 1 14 HET NAG t 2 14 HET NAG u 1 14 HET NAG u 2 14 HET NAG v 1 14 HET NAG v 2 14 HET NAG w 1 14 HET NAG w 2 14 HET NAG x 1 14 HET NAG x 2 14 HET NAG b 601 14 HET NAG b 602 14 HET NAG b 603 14 HET NAG b 604 14 HET NAG b 605 14 HET NAG b 606 14 HET NAG b 607 14 HET NAG b 608 14 HET NAG c 701 14 HET NAG c 702 14 HET NAG c 703 14 HET NAG d 601 14 HET NAG d 602 14 HET NAG d 603 14 HET NAG d 604 14 HET NAG d 605 14 HET NAG d 606 14 HET NAG e 701 14 HET NAG e 702 14 HET NAG e 703 14 HET NAG f 601 14 HET NAG f 602 14 HET NAG f 603 14 HET NAG f 604 14 HET NAG f 605 14 HET NAG f 606 14 HET NAG f 607 14 HET NAG f 608 14 HET NAG g 701 14 HET NAG g 702 14 HET NAG g 703 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 13 NAG 107(C8 H15 N O6) FORMUL 14 BMA 13(C6 H12 O6) FORMUL 15 MAN 21(C6 H12 O6) HELIX 1 AA1 THR H 28 TYR H 32 5 5 HELIX 2 AA2 ARG H 83 THR H 87 5 5 HELIX 3 AA3 GLN L 79 PHE L 83 5 5 HELIX 4 AA4 ALA b 70 CYS b 74 5 5 HELIX 5 AA5 ASN b 99 LYS b 117 1 19 HELIX 6 AA6 LEU b 122 CYS b 126 5 5 HELIX 7 AA7 SER b 334 THR b 351 1 18 HELIX 8 AA8 ASP b 368 THR b 373 1 6 HELIX 9 AA9 THR b 387 LEU b 390 5 4 HELIX 10 AB1 MET b 475 TYR b 484 1 10 HELIX 11 AB2 LEU c 523 GLY c 527 5 5 HELIX 12 AB3 THR c 529 SER c 534 1 6 HELIX 13 AB4 THR c 536 GLN c 543 1 8 HELIX 14 AB5 GLY c 569 TRP c 596 1 28 HELIX 15 AB6 SER c 618 ASN c 625 1 8 HELIX 16 AB7 THR c 627 GLY c 636 1 10 HELIX 17 AB8 TYR c 638 LYS c 658 1 21 HELIX 18 AB9 THR I 28 TYR I 32 5 5 HELIX 19 AC1 ARG I 83 THR I 87 5 5 HELIX 20 AC2 GLN M 79 PHE M 83 5 5 HELIX 21 AC3 ALA d 70 CYS d 74 5 5 HELIX 22 AC4 ASN d 99 LYS d 117 1 19 HELIX 23 AC5 LEU d 122 CYS d 126 5 5 HELIX 24 AC6 SER d 334 THR d 351 1 18 HELIX 25 AC7 ASP d 368 THR d 373 1 6 HELIX 26 AC8 MET d 475 TYR d 484 1 10 HELIX 27 AC9 LEU e 523 GLY e 527 5 5 HELIX 28 AD1 THR e 529 SER e 534 1 6 HELIX 29 AD2 THR e 536 GLN e 543 1 8 HELIX 30 AD3 LEU e 544 SER e 546 5 3 HELIX 31 AD4 GLY e 569 TRP e 596 1 28 HELIX 32 AD5 LEU e 619 ASN e 625 1 7 HELIX 33 AD6 THR e 627 LYS e 658 1 32 HELIX 34 AD7 THR J 28 TYR J 32 5 5 HELIX 35 AD8 ARG J 83 THR J 87 5 5 HELIX 36 AD9 GLN N 79 PHE N 83 5 5 HELIX 37 AE1 ALA f 70 CYS f 74 5 5 HELIX 38 AE2 ASN f 98 LYS f 117 1 20 HELIX 39 AE3 SER f 334 THR f 351 1 18 HELIX 40 AE4 ASP f 368 THR f 373 1 6 HELIX 41 AE5 THR f 387 LEU f 390 5 4 HELIX 42 AE6 MET f 475 TYR f 484 1 10 HELIX 43 AE7 LEU g 523 GLY g 527 5 5 HELIX 44 AE8 THR g 529 SER g 534 1 6 HELIX 45 AE9 THR g 536 GLN g 543 1 8 HELIX 46 AF1 LEU g 544 SER g 546 5 3 HELIX 47 AF2 GLY g 569 TRP g 596 1 28 HELIX 48 AF3 ASP g 620 ASN g 625 1 6 HELIX 49 AF4 THR g 627 GLY g 636 1 10 HELIX 50 AF5 TYR g 638 LYS g 658 1 21 SHEET 1 AA1 4 HIS H 3 SER H 7 0 SHEET 2 AA1 4 SER H 17 SER H 25 -1 O ALA H 23 N VAL H 5 SHEET 3 AA1 4 THR H 77 ASN H 82A-1 O LEU H 78 N CYS H 22 SHEET 4 AA1 4 PHE H 67 ASP H 72 -1 N SER H 70 O SER H 79 SHEET 1 AA2 6 LEU H 11 ALA H 12 0 SHEET 2 AA2 6 VAL H 107 VAL H 111 1 O THR H 110 N ALA H 12 SHEET 3 AA2 6 ALA H 88 VAL H 95 -1 N TYR H 90 O VAL H 107 SHEET 4 AA2 6 MET H 34 GLN H 39 -1 N VAL H 37 O TYR H 91 SHEET 5 AA2 6 LEU H 45 ILE H 51 -1 O ILE H 48 N TRP H 36 SHEET 6 AA2 6 ARG H 57 TYR H 59 -1 O ASP H 58 N SER H 50 SHEET 1 AA3 4 LEU H 11 ALA H 12 0 SHEET 2 AA3 4 VAL H 107 VAL H 111 1 O THR H 110 N ALA H 12 SHEET 3 AA3 4 ALA H 88 VAL H 95 -1 N TYR H 90 O VAL H 107 SHEET 4 AA3 4 PHE H 100O TRP H 103 -1 O TYR H 102 N LYS H 94 SHEET 1 AA4 4 GLY H 100A PHE H 100C 0 SHEET 2 AA4 4 ARG b 169 TYR b 177 -1 O ARG b 169 N PHE H 100C SHEET 3 AA4 4 LEU b 154 THR b 162 -1 N MET b 161 O GLN b 170 SHEET 4 AA4 4 HIS b 130 ASN b 133 -1 N THR b 132 O ASN b 156 SHEET 1 AA5 4 MET L 4 SER L 7 0 SHEET 2 AA5 4 THR L 20 ALA L 25 -1 O GLN L 24 N THR L 5 SHEET 3 AA5 4 ASP L 70 THR L 74 -1 O LEU L 73 N ILE L 21 SHEET 4 AA5 4 SER L 63 SER L 67 -1 N SER L 65 O THR L 72 SHEET 1 AA6 2 SER L 10 ALA L 13 0 SHEET 2 AA6 2 GLU L 103 ILE L 106 1 O GLU L 105 N ALA L 13 SHEET 1 AA7 3 LYS L 45 ILE L 48 0 SHEET 2 AA7 3 LEU L 33 GLN L 38 -1 N TRP L 35 O ILE L 48 SHEET 3 AA7 3 THR L 85 GLN L 90 -1 O GLN L 89 N ALA L 34 SHEET 1 AA8 3 LEU b 494 THR b 499 0 SHEET 2 AA8 3 TRP b 35 TYR b 40 -1 N TYR b 39 O GLY b 495 SHEET 3 AA8 3 ILE c 603 PRO c 609 -1 O VAL c 608 N VAL b 36 SHEET 1 AA9 5 TRP b 45 ASP b 47 0 SHEET 2 AA9 5 TYR b 486 ILE b 491 -1 O GLU b 490 N ARG b 46 SHEET 3 AA9 5 PHE b 223 CYS b 228 -1 N LEU b 226 O LYS b 487 SHEET 4 AA9 5 VAL b 242 VAL b 245 -1 O SER b 243 N LYS b 227 SHEET 5 AA9 5 GLU b 83 LEU b 86 -1 N ILE b 84 O THR b 244 SHEET 1 AB1 2 ALA b 55 SER b 56 0 SHEET 2 AB1 2 VAL b 75 PRO b 76 1 O VAL b 75 N SER b 56 SHEET 1 AB2 2 HIS b 66 ASN b 67 0 SHEET 2 AB2 2 VAL b 208 SER b 209 1 O SER b 209 N HIS b 66 SHEET 1 AB3 2 GLU b 91 ASN b 94 0 SHEET 2 AB3 2 THR b 236 CYS b 239 -1 O CYS b 239 N GLU b 91 SHEET 1 AB4 2 ILE b 181 PRO b 183 0 SHEET 2 AB4 2 TYR b 191 LEU b 193 -1 O ARG b 192 N VAL b 182 SHEET 1 AB5 3 THR b 202 GLN b 203 0 SHEET 2 AB5 3 MET b 434 TYR b 435 1 O TYR b 435 N THR b 202 SHEET 3 AB5 3 ILE b 423 ILE b 424 -1 N ILE b 424 O MET b 434 SHEET 1 AB6 7 LEU b 259 LEU b 261 0 SHEET 2 AB6 7 ILE b 443 ARG b 456 -1 O GLY b 451 N LEU b 260 SHEET 3 AB6 7 ILE b 284 ARG b 298 -1 N ILE b 284 O LEU b 454 SHEET 4 AB6 7 ALA b 329 VAL b 333 -1 O ASN b 332 N LYS b 295 SHEET 5 AB6 7 ILE b 414 LYS b 421 -1 O ILE b 414 N VAL b 333 SHEET 6 AB6 7 PHE b 382 CYS b 385 -1 N TYR b 384 O ARG b 419 SHEET 7 AB6 7 HIS b 374 ASN b 377 -1 N HIS b 374 O CYS b 385 SHEET 1 AB7 6 THR b 271 ARG b 273 0 SHEET 2 AB7 6 ILE b 284 ARG b 298 -1 O ILE b 285 N ARG b 273 SHEET 3 AB7 6 ILE b 443 ARG b 456 -1 O LEU b 454 N ILE b 284 SHEET 4 AB7 6 ASN b 465 PRO b 470 -1 O ARG b 469 N THR b 455 SHEET 5 AB7 6 THR b 357 PHE b 361 1 N ILE b 359 O PHE b 468 SHEET 6 AB7 6 SER b 393 TRP b 395 -1 O TRP b 395 N ILE b 358 SHEET 1 AB8 2 ASN b 301 GLY b 312 0 SHEET 2 AB8 2 GLN b 315 ILE b 323A-1 O PHE b 317 N ILE b 307 SHEET 1 AB9 4 HIS I 3 SER I 7 0 SHEET 2 AB9 4 SER I 17 SER I 25 -1 O SER I 21 N SER I 7 SHEET 3 AB9 4 THR I 77 ASN I 82A-1 O MET I 82 N LEU I 18 SHEET 4 AB9 4 PHE I 67 ASP I 72 -1 N SER I 70 O SER I 79 SHEET 1 AC1 6 LEU I 11 ALA I 12 0 SHEET 2 AC1 6 VAL I 107 VAL I 111 1 O THR I 110 N ALA I 12 SHEET 3 AC1 6 ALA I 88 VAL I 95 -1 N TYR I 90 O VAL I 107 SHEET 4 AC1 6 MET I 34 GLN I 39 -1 N VAL I 37 O TYR I 91 SHEET 5 AC1 6 LEU I 45 ILE I 51 -1 O ILE I 51 N MET I 34 SHEET 6 AC1 6 ARG I 57 TYR I 59 -1 O ASP I 58 N SER I 50 SHEET 1 AC2 4 LEU I 11 ALA I 12 0 SHEET 2 AC2 4 VAL I 107 VAL I 111 1 O THR I 110 N ALA I 12 SHEET 3 AC2 4 ALA I 88 VAL I 95 -1 N TYR I 90 O VAL I 107 SHEET 4 AC2 4 PHE I 100O TRP I 103 -1 O TYR I 102 N LYS I 94 SHEET 1 AC3 4 GLY I 100A PHE I 100C 0 SHEET 2 AC3 4 ARG d 169 TYR d 177 -1 O ARG d 169 N PHE I 100C SHEET 3 AC3 4 LEU d 154 MET d 161 -1 N PHE d 159 O VAL d 172 SHEET 4 AC3 4 HIS d 130 ASN d 133 -1 N THR d 132 O ASN d 156 SHEET 1 AC4 4 MET M 4 SER M 7 0 SHEET 2 AC4 4 THR M 20 ALA M 25 -1 O GLN M 24 N THR M 5 SHEET 3 AC4 4 ASP M 70 THR M 74 -1 O LEU M 73 N ILE M 21 SHEET 4 AC4 4 SER M 63 SER M 67 -1 N SER M 65 O THR M 72 SHEET 1 AC5 5 SER M 10 ALA M 13 0 SHEET 2 AC5 5 THR M 102 ILE M 106 1 O GLU M 105 N ALA M 13 SHEET 3 AC5 5 THR M 85 GLN M 90 -1 N TYR M 86 O THR M 102 SHEET 4 AC5 5 LEU M 33 GLN M 38 -1 N ALA M 34 O GLN M 89 SHEET 5 AC5 5 LYS M 45 ILE M 48 -1 O LYS M 45 N GLN M 37 SHEET 1 AC6 3 LEU d 494 THR d 499 0 SHEET 2 AC6 3 TRP d 35 TYR d 40 -1 N TYR d 39 O GLY d 495 SHEET 3 AC6 3 ILE e 603 PRO e 609 -1 O VAL e 608 N VAL d 36 SHEET 1 AC7 5 TRP d 45 ASP d 47 0 SHEET 2 AC7 5 TYR d 486 ILE d 491 -1 O GLU d 490 N ARG d 46 SHEET 3 AC7 5 PHE d 223 CYS d 228 -1 N LEU d 226 O LYS d 487 SHEET 4 AC7 5 VAL d 242 VAL d 245 -1 O SER d 243 N LYS d 227 SHEET 5 AC7 5 GLU d 83 HIS d 85 -1 N ILE d 84 O THR d 244 SHEET 1 AC8 3 VAL d 75 PRO d 76 0 SHEET 2 AC8 3 PHE d 53 SER d 56 1 N SER d 56 O VAL d 75 SHEET 3 AC8 3 HIS d 216 CYS d 218 -1 O HIS d 216 N ALA d 55 SHEET 1 AC9 2 HIS d 66 ASN d 67 0 SHEET 2 AC9 2 VAL d 208 SER d 209 1 O SER d 209 N HIS d 66 SHEET 1 AD1 2 GLU d 91 ASN d 94 0 SHEET 2 AD1 2 THR d 236 CYS d 239 -1 O CYS d 239 N GLU d 91 SHEET 1 AD2 2 ILE d 181 PRO d 183 0 SHEET 2 AD2 2 TYR d 191 LEU d 193 -1 O ARG d 192 N VAL d 182 SHEET 1 AD3 3 THR d 202 GLN d 203 0 SHEET 2 AD3 3 MET d 434 TYR d 435 1 O TYR d 435 N THR d 202 SHEET 3 AD3 3 ILE d 423 ILE d 424 -1 N ILE d 424 O MET d 434 SHEET 1 AD4 7 LEU d 259 LEU d 261 0 SHEET 2 AD4 7 ILE d 443 ARG d 456 -1 O GLY d 451 N LEU d 260 SHEET 3 AD4 7 ILE d 284 ARG d 298 -1 N ILE d 284 O LEU d 454 SHEET 4 AD4 7 HIS d 330 VAL d 333 -1 O ASN d 332 N LYS d 295 SHEET 5 AD4 7 ILE d 414 LYS d 421 -1 O ILE d 414 N VAL d 333 SHEET 6 AD4 7 PHE d 382 CYS d 385 -1 N TYR d 384 O ARG d 419 SHEET 7 AD4 7 HIS d 374 ASN d 377 -1 N HIS d 374 O CYS d 385 SHEET 1 AD5 6 THR d 271 ARG d 273 0 SHEET 2 AD5 6 ILE d 284 ARG d 298 -1 O ILE d 285 N ARG d 273 SHEET 3 AD5 6 ILE d 443 ARG d 456 -1 O LEU d 454 N ILE d 284 SHEET 4 AD5 6 ASN d 465 PRO d 470 -1 O ARG d 469 N THR d 455 SHEET 5 AD5 6 THR d 357 PHE d 361 1 N ILE d 359 O GLU d 466 SHEET 6 AD5 6 SER d 393 TRP d 395 -1 O TRP d 395 N ILE d 358 SHEET 1 AD6 2 ASN d 301 GLY d 312 0 SHEET 2 AD6 2 GLN d 315 ILE d 323A-1 O PHE d 317 N ILE d 307 SHEET 1 AD7 4 HIS J 3 SER J 7 0 SHEET 2 AD7 4 SER J 17 SER J 25 -1 O SER J 21 N SER J 7 SHEET 3 AD7 4 THR J 77 ASN J 82A-1 O LEU J 78 N CYS J 22 SHEET 4 AD7 4 PHE J 67 ASP J 72 -1 N SER J 70 O SER J 79 SHEET 1 AD8 6 LEU J 11 ALA J 12 0 SHEET 2 AD8 6 VAL J 107 VAL J 111 1 O THR J 110 N ALA J 12 SHEET 3 AD8 6 ALA J 88 VAL J 95 -1 N ALA J 88 O VAL J 109 SHEET 4 AD8 6 MET J 34 GLN J 39 -1 N VAL J 37 O TYR J 91 SHEET 5 AD8 6 LEU J 45 ILE J 51 -1 O ILE J 48 N TRP J 36 SHEET 6 AD8 6 ARG J 57 TYR J 59 -1 O ASP J 58 N SER J 50 SHEET 1 AD9 4 LEU J 11 ALA J 12 0 SHEET 2 AD9 4 VAL J 107 VAL J 111 1 O THR J 110 N ALA J 12 SHEET 3 AD9 4 ALA J 88 VAL J 95 -1 N ALA J 88 O VAL J 109 SHEET 4 AD9 4 PHE J 100O TRP J 103 -1 O TYR J 102 N LYS J 94 SHEET 1 AE1 4 GLY J 100A PHE J 100C 0 SHEET 2 AE1 4 ARG f 169 TYR f 177 -1 O ARG f 169 N PHE J 100C SHEET 3 AE1 4 LEU f 154 THR f 162 -1 N MET f 161 O GLN f 170 SHEET 4 AE1 4 HIS f 130 ASN f 133 -1 N THR f 132 O ASN f 156 SHEET 1 AE2 4 MET N 4 SER N 7 0 SHEET 2 AE2 4 VAL N 19 ALA N 25 -1 O GLN N 24 N THR N 5 SHEET 3 AE2 4 ASP N 70 ILE N 75 -1 O LEU N 73 N ILE N 21 SHEET 4 AE2 4 GLY N 64 SER N 67 -1 N SER N 65 O THR N 72 SHEET 1 AE3 5 SER N 10 ALA N 13 0 SHEET 2 AE3 5 THR N 102 ILE N 106 1 O GLU N 105 N ALA N 13 SHEET 3 AE3 5 THR N 85 GLN N 90 -1 N TYR N 86 O THR N 102 SHEET 4 AE3 5 LEU N 33 GLN N 38 -1 N ALA N 34 O GLN N 89 SHEET 5 AE3 5 LYS N 45 ILE N 48 -1 O LYS N 45 N GLN N 37 SHEET 1 AE4 3 LEU f 494 THR f 499 0 SHEET 2 AE4 3 TRP f 35 TYR f 40 -1 N TYR f 39 O GLY f 495 SHEET 3 AE4 3 ILE g 603 PRO g 609 -1 O VAL g 608 N VAL f 36 SHEET 1 AE5 5 TRP f 45 ASP f 47 0 SHEET 2 AE5 5 TYR f 486 ILE f 491 -1 O GLU f 490 N ARG f 46 SHEET 3 AE5 5 PHE f 223 CYS f 228 -1 N LEU f 226 O LYS f 487 SHEET 4 AE5 5 VAL f 242 VAL f 245 -1 O SER f 243 N LYS f 227 SHEET 5 AE5 5 GLU f 83 HIS f 85 -1 N ILE f 84 O THR f 244 SHEET 1 AE6 3 VAL f 75 PRO f 76 0 SHEET 2 AE6 3 PHE f 53 SER f 56 1 N SER f 56 O VAL f 75 SHEET 3 AE6 3 HIS f 216 CYS f 218 -1 O HIS f 216 N ALA f 55 SHEET 1 AE7 2 GLU f 91 ASN f 94 0 SHEET 2 AE7 2 THR f 236 CYS f 239 -1 O CYS f 239 N GLU f 91 SHEET 1 AE8 2 ILE f 181 PRO f 183 0 SHEET 2 AE8 2 TYR f 191 LEU f 193 -1 O ARG f 192 N VAL f 182 SHEET 1 AE9 3 THR f 202 GLN f 203 0 SHEET 2 AE9 3 MET f 434 TYR f 435 1 O TYR f 435 N THR f 202 SHEET 3 AE9 3 ILE f 423 ILE f 424 -1 N ILE f 424 O MET f 434 SHEET 1 AF1 7 LEU f 259 LEU f 261 0 SHEET 2 AF1 7 ILE f 443 ARG f 456 -1 O GLY f 451 N LEU f 260 SHEET 3 AF1 7 ILE f 284 ARG f 298 -1 N ILE f 284 O LEU f 454 SHEET 4 AF1 7 ALA f 329 VAL f 333 -1 O ASN f 332 N LYS f 295 SHEET 5 AF1 7 ILE f 414 LYS f 421 -1 O ILE f 414 N VAL f 333 SHEET 6 AF1 7 PHE f 382 CYS f 385 -1 N TYR f 384 O ARG f 419 SHEET 7 AF1 7 HIS f 374 ASN f 377 -1 N HIS f 374 O CYS f 385 SHEET 1 AF2 6 THR f 271 ARG f 273 0 SHEET 2 AF2 6 ILE f 284 ARG f 298 -1 O GLN f 287 N THR f 271 SHEET 3 AF2 6 ILE f 443 ARG f 456 -1 O LEU f 454 N ILE f 284 SHEET 4 AF2 6 ASN f 465 PRO f 470 -1 O ARG f 469 N THR f 455 SHEET 5 AF2 6 THR f 357 PHE f 361 1 N ILE f 359 O PHE f 468 SHEET 6 AF2 6 SER f 393 TRP f 395 -1 O TRP f 395 N ILE f 358 SHEET 1 AF3 2 ASN f 301 GLY f 312 0 SHEET 2 AF3 2 GLN f 315 ILE f 323A-1 O PHE f 317 N ILE f 307 SSBOND 1 CYS H 22 CYS H 92 1555 1555 2.03 SSBOND 2 CYS L 23 CYS L 88 1555 1555 2.03 SSBOND 3 CYS b 54 CYS b 74 1555 1555 2.04 SSBOND 4 CYS b 119 CYS b 205 1555 1555 2.03 SSBOND 5 CYS b 126 CYS b 196 1555 1555 2.04 SSBOND 6 CYS b 131 CYS b 157 1555 1555 2.03 SSBOND 7 CYS b 201 CYS b 433 1555 1555 2.03 SSBOND 8 CYS b 218 CYS b 247 1555 1555 2.03 SSBOND 9 CYS b 228 CYS b 239 1555 1555 2.03 SSBOND 10 CYS b 296 CYS b 331 1555 1555 2.03 SSBOND 11 CYS b 378 CYS b 445 1555 1555 2.06 SSBOND 12 CYS b 385 CYS b 418 1555 1555 2.03 SSBOND 13 CYS b 501 CYS c 605 1555 1555 2.03 SSBOND 14 CYS c 598 CYS c 604 1555 1555 2.03 SSBOND 15 CYS I 22 CYS I 92 1555 1555 2.03 SSBOND 16 CYS M 23 CYS M 88 1555 1555 2.03 SSBOND 17 CYS d 54 CYS d 74 1555 1555 2.04 SSBOND 18 CYS d 119 CYS d 205 1555 1555 2.03 SSBOND 19 CYS d 126 CYS d 196 1555 1555 2.03 SSBOND 20 CYS d 131 CYS d 157 1555 1555 2.03 SSBOND 21 CYS d 201 CYS d 433 1555 1555 2.03 SSBOND 22 CYS d 218 CYS d 247 1555 1555 2.03 SSBOND 23 CYS d 228 CYS d 239 1555 1555 2.03 SSBOND 24 CYS d 296 CYS d 331 1555 1555 2.03 SSBOND 25 CYS d 378 CYS d 445 1555 1555 2.03 SSBOND 26 CYS d 385 CYS d 418 1555 1555 2.03 SSBOND 27 CYS d 501 CYS e 605 1555 1555 2.03 SSBOND 28 CYS e 598 CYS e 604 1555 1555 2.03 SSBOND 29 CYS J 22 CYS J 92 1555 1555 2.03 SSBOND 30 CYS N 23 CYS N 88 1555 1555 2.03 SSBOND 31 CYS f 54 CYS f 74 1555 1555 2.04 SSBOND 32 CYS f 119 CYS f 205 1555 1555 2.03 SSBOND 33 CYS f 126 CYS f 196 1555 1555 2.03 SSBOND 34 CYS f 131 CYS f 157 1555 1555 2.03 SSBOND 35 CYS f 201 CYS f 433 1555 1555 2.03 SSBOND 36 CYS f 218 CYS f 247 1555 1555 2.03 SSBOND 37 CYS f 228 CYS f 239 1555 1555 2.03 SSBOND 38 CYS f 296 CYS f 331 1555 1555 2.03 SSBOND 39 CYS f 378 CYS f 445 1555 1555 2.03 SSBOND 40 CYS f 385 CYS f 418 1555 1555 2.03 SSBOND 41 CYS f 501 CYS g 605 1555 1555 2.03 SSBOND 42 CYS g 598 CYS g 604 1555 1555 2.03 LINK ND2 ASN b 88 C1 NAG b 601 1555 1555 1.45 LINK ND2 ASN b 133 C1 NAG b 602 1555 1555 1.44 LINK ND2 ASN b 156 C1 NAG D 1 1555 1555 1.44 LINK ND2 ASN b 160 C1 NAG E 1 1555 1555 1.44 LINK ND2 ASN b 197 C1 NAG F 1 1555 1555 1.44 LINK ND2 ASN b 234 C1 NAG G 1 1555 1555 1.44 LINK ND2 ASN b 241 C1 NAG K 1 1555 1555 1.44 LINK ND2 ASN b 262 C1 NAG C 1 1555 1555 1.44 LINK ND2 ASN b 269 C1 NAG b 605 1555 1555 1.44 LINK ND2 ASN b 276 C1 NAG O 1 1555 1555 1.44 LINK ND2 ASN b 301 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN b 332 C1 NAG B 1 1555 1555 1.44 LINK ND2 ASN b 339 C1 NAG b 603 1555 1555 1.45 LINK ND2 ASN b 355 C1 NAG b 604 1555 1555 1.44 LINK ND2 ASN b 363 C1 NAG b 606 1555 1555 1.42 LINK ND2 ASN b 386 C1 NAG b 607 1555 1555 1.43 LINK ND2 ASN b 392 C1 NAG A 1 1555 1555 1.44 LINK ND2 ASN b 398 C1 NAG b 608 1555 1555 1.45 LINK ND2 ASN b 448 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN b 465 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN c 611 C1 NAG c 701 1555 1555 1.44 LINK ND2 ASN c 625 C1 NAG c 703 1555 1555 1.44 LINK ND2 ASN c 637 C1 NAG c 702 1555 1555 1.44 LINK ND2 ASN d 88 C1 NAG d 601 1555 1555 1.45 LINK ND2 ASN d 133 C1 NAG d 602 1555 1555 1.44 LINK ND2 ASN d 156 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN d 160 C1 NAG W 1 1555 1555 1.44 LINK ND2 ASN d 197 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN d 234 C1 NAG Y 1 1555 1555 1.44 LINK ND2 ASN d 241 C1 NAG Z 1 1555 1555 1.44 LINK ND2 ASN d 262 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN d 269 C1 NAG d 604 1555 1555 1.44 LINK ND2 ASN d 276 C1 NAG a 1 1555 1555 1.44 LINK ND2 ASN d 301 C1 NAG h 1 1555 1555 1.44 LINK ND2 ASN d 332 C1 NAG T 1 1555 1555 1.44 LINK ND2 ASN d 339 C1 NAG d 605 1555 1555 1.42 LINK ND2 ASN d 355 C1 NAG d 603 1555 1555 1.44 LINK ND2 ASN d 392 C1 NAG S 1 1555 1555 1.44 LINK ND2 ASN d 398 C1 NAG d 606 1555 1555 1.44 LINK ND2 ASN d 448 C1 NAG k 1 1555 1555 1.44 LINK ND2 ASN d 465 C1 NAG l 1 1555 1555 1.44 LINK ND2 ASN e 611 C1 NAG e 701 1555 1555 1.44 LINK ND2 ASN e 625 C1 NAG e 703 1555 1555 1.44 LINK ND2 ASN e 637 C1 NAG e 702 1555 1555 1.44 LINK ND2 ASN f 88 C1 NAG f 601 1555 1555 1.45 LINK ND2 ASN f 133 C1 NAG f 602 1555 1555 1.44 LINK ND2 ASN f 156 C1 NAG p 1 1555 1555 1.44 LINK ND2 ASN f 160 C1 NAG q 1 1555 1555 1.44 LINK ND2 ASN f 197 C1 NAG r 1 1555 1555 1.44 LINK ND2 ASN f 234 C1 NAG s 1 1555 1555 1.44 LINK ND2 ASN f 241 C1 NAG t 1 1555 1555 1.44 LINK ND2 ASN f 262 C1 NAG o 1 1555 1555 1.44 LINK ND2 ASN f 269 C1 NAG f 605 1555 1555 1.44 LINK ND2 ASN f 276 C1 NAG u 1 1555 1555 1.45 LINK ND2 ASN f 301 C1 NAG v 1 1555 1555 1.44 LINK ND2 ASN f 332 C1 NAG n 1 1555 1555 1.44 LINK ND2 ASN f 339 C1 NAG f 603 1555 1555 1.45 LINK ND2 ASN f 355 C1 NAG f 604 1555 1555 1.44 LINK ND2 ASN f 363 C1 NAG f 608 1555 1555 1.42 LINK ND2 ASN f 386 C1 NAG f 607 1555 1555 1.43 LINK ND2 ASN f 392 C1 NAG m 1 1555 1555 1.44 LINK ND2 ASN f 398 C1 NAG f 606 1555 1555 1.43 LINK ND2 ASN f 448 C1 NAG w 1 1555 1555 1.44 LINK ND2 ASN f 465 C1 NAG x 1 1555 1555 1.45 LINK ND2 ASN g 611 C1 NAG g 701 1555 1555 1.44 LINK ND2 ASN g 625 C1 NAG g 703 1555 1555 1.44 LINK ND2 ASN g 637 C1 NAG g 702 1555 1555 1.44 LINK O4 NAG A 1 C1 NAG A 2 1555 1555 1.44 LINK O4 NAG B 1 C1 NAG B 2 1555 1555 1.45 LINK O4 NAG B 2 C1 BMA B 3 1555 1555 1.45 LINK O4 NAG C 1 C1 NAG C 2 1555 1555 1.45 LINK O4 NAG C 2 C1 BMA C 3 1555 1555 1.45 LINK O3 BMA C 3 C1 MAN C 4 1555 1555 1.46 LINK O6 BMA C 3 C1 MAN C 5 1555 1555 1.45 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.44 LINK O4 NAG D 2 C1 BMA D 3 1555 1555 1.50 LINK O6 BMA D 3 C1 MAN D 4 1555 1555 1.45 LINK O6 MAN D 4 C1 MAN D 5 1555 1555 1.45 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.44 LINK O4 NAG E 2 C1 BMA E 3 1555 1555 1.45 LINK O3 BMA E 3 C1 MAN E 4 1555 1555 1.46 LINK O6 BMA E 3 C1 MAN E 6 1555 1555 1.46 LINK O2 MAN E 4 C1 MAN E 5 1555 1555 1.45 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.44 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.45 LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.45 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.45 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.44 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.45 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.44 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.45 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.45 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.45 LINK O4 NAG U 2 C1 BMA U 3 1555 1555 1.44 LINK O3 BMA U 3 C1 MAN U 4 1555 1555 1.46 LINK O6 BMA U 3 C1 MAN U 5 1555 1555 1.45 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG V 2 C1 BMA V 3 1555 1555 1.45 LINK O6 BMA V 3 C1 MAN V 4 1555 1555 1.46 LINK O6 MAN V 4 C1 MAN V 5 1555 1555 1.45 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.44 LINK O4 NAG W 2 C1 BMA W 3 1555 1555 1.45 LINK O3 BMA W 3 C1 MAN W 4 1555 1555 1.46 LINK O6 BMA W 3 C1 MAN W 6 1555 1555 1.46 LINK O2 MAN W 4 C1 MAN W 5 1555 1555 1.45 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.45 LINK O4 NAG Z 1 C1 NAG Z 2 1555 1555 1.45 LINK O4 NAG a 1 C1 NAG a 2 1555 1555 1.45 LINK O4 NAG h 1 C1 NAG h 2 1555 1555 1.44 LINK O4 NAG i 1 C1 NAG i 2 1555 1555 1.45 LINK O4 NAG j 1 C1 NAG j 2 1555 1555 1.45 LINK O4 NAG k 1 C1 NAG k 2 1555 1555 1.44 LINK O4 NAG l 1 C1 NAG l 2 1555 1555 1.44 LINK O4 NAG m 1 C1 NAG m 2 1555 1555 1.44 LINK O4 NAG n 1 C1 NAG n 2 1555 1555 1.44 LINK O4 NAG n 2 C1 BMA n 3 1555 1555 1.45 LINK O4 NAG o 1 C1 NAG o 2 1555 1555 1.44 LINK O4 NAG o 2 C1 BMA o 3 1555 1555 1.45 LINK O3 BMA o 3 C1 MAN o 4 1555 1555 1.46 LINK O6 BMA o 3 C1 MAN o 5 1555 1555 1.45 LINK O4 NAG p 1 C1 NAG p 2 1555 1555 1.44 LINK O4 NAG p 2 C1 BMA p 3 1555 1555 1.45 LINK O6 BMA p 3 C1 MAN p 4 1555 1555 1.46 LINK O6 MAN p 4 C1 MAN p 5 1555 1555 1.45 LINK O4 NAG q 1 C1 NAG q 2 1555 1555 1.44 LINK O4 NAG q 2 C1 BMA q 3 1555 1555 1.45 LINK O3 BMA q 3 C1 MAN q 4 1555 1555 1.46 LINK O6 BMA q 3 C1 MAN q 6 1555 1555 1.46 LINK O2 MAN q 4 C1 MAN q 5 1555 1555 1.45 LINK O4 NAG r 1 C1 NAG r 2 1555 1555 1.44 LINK O4 NAG s 1 C1 NAG s 2 1555 1555 1.45 LINK O4 NAG t 1 C1 NAG t 2 1555 1555 1.45 LINK O4 NAG u 1 C1 NAG u 2 1555 1555 1.45 LINK O4 NAG v 1 C1 NAG v 2 1555 1555 1.44 LINK O4 NAG w 1 C1 NAG w 2 1555 1555 1.45 LINK O4 NAG x 1 C1 NAG x 2 1555 1555 1.39 CISPEP 1 SER L 7 PRO L 8 0 -0.91 CISPEP 2 SER M 7 PRO M 8 0 -1.00 CISPEP 3 SER N 7 PRO N 8 0 -0.58 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000