HEADER VIRAL PROTEIN 20-JUN-25 9P6X TITLE STRUCTURE OF EBOV GLYCOPROTEIN IN COMPLEX WITH NANOSOTA-EB1 AND EB2 COMPND MOL_ID: 1; COMPND 2 MOLECULE: ENVELOPE GLYCOPROTEIN; COMPND 3 CHAIN: A, B, C; COMPND 4 SYNONYM: GP1,2,GP,GP1,2-DELTA; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: NANOSOTA-EB1; COMPND 8 CHAIN: D, E, F; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: NANOSOTA-EB2; COMPND 12 CHAIN: G, H, I; COMPND 13 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: EBOLA VIRUS; SOURCE 3 ORGANISM_TAXID: 1570291; SOURCE 4 GENE: GP; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 MOL_ID: 2; SOURCE 8 ORGANISM_SCIENTIFIC: VICUGNA PACOS; SOURCE 9 ORGANISM_TAXID: 30538; SOURCE 10 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 11 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 12 MOL_ID: 3; SOURCE 13 ORGANISM_SCIENTIFIC: VICUGNA PACOS; SOURCE 14 ORGANISM_TAXID: 30538; SOURCE 15 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS EBOV, GLYCOPROTEIN, NANOBODY, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR F.BU,G.YE,F.LI REVDAT 1 21-JAN-26 9P6X 0 JRNL AUTH F.BU,G.YE,F.LI JRNL TITL A HIGHLY POTENT AND BROADLY ACCESSIBLE BISPECIFIC NANOBODY JRNL TITL 2 FOR THE TREATMENT OF EBOLA VIRUS INFECTIONS JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.92 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.920 REMARK 3 NUMBER OF PARTICLES : 62575 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9P6X COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-JUN-25. REMARK 100 THE DEPOSITION ID IS D_1000297003. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : EBOV GLYCOPROTEIN IN COMPLEX REMARK 245 WITH NANOSOTA-EB1 AND EB2; EBOV REMARK 245 GLYCOPROTEIN; NANOSOTA-EB1 AND REMARK 245 EB2 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 9 REMARK 465 ASP A 10 REMARK 465 ALA A 11 REMARK 465 MET A 12 REMARK 465 LYS A 13 REMARK 465 ARG A 14 REMARK 465 GLY A 15 REMARK 465 LEU A 16 REMARK 465 CYS A 17 REMARK 465 CYS A 18 REMARK 465 VAL A 19 REMARK 465 LEU A 20 REMARK 465 LEU A 21 REMARK 465 LEU A 22 REMARK 465 CYS A 23 REMARK 465 GLY A 24 REMARK 465 ALA A 25 REMARK 465 VAL A 26 REMARK 465 PHE A 27 REMARK 465 VAL A 28 REMARK 465 SER A 29 REMARK 465 ALA A 30 REMARK 465 SER A 31 REMARK 465 LEU A 199 REMARK 465 ARG A 200 REMARK 465 GLU A 201 REMARK 465 PRO A 202 REMARK 465 VAL A 203 REMARK 465 ASN A 204 REMARK 465 ALA A 205 REMARK 465 THR A 206 REMARK 465 GLU A 207 REMARK 465 ASP A 208 REMARK 465 PRO A 209 REMARK 465 SER A 210 REMARK 465 SER A 211 REMARK 465 THR A 434 REMARK 465 THR A 435 REMARK 465 ILE A 436 REMARK 465 GLY A 437 REMARK 465 GLU A 438 REMARK 465 TRP A 439 REMARK 465 ALA A 440 REMARK 465 PHE A 441 REMARK 465 TRP A 442 REMARK 465 GLU A 443 REMARK 465 THR A 444 REMARK 465 LYS A 445 REMARK 465 LYS A 446 REMARK 465 ASN A 447 REMARK 465 LEU A 448 REMARK 465 THR A 449 REMARK 465 ARG A 450 REMARK 465 LYS A 451 REMARK 465 ILE A 452 REMARK 465 ARG A 453 REMARK 465 SER A 454 REMARK 465 GLU A 455 REMARK 465 GLU A 456 REMARK 465 LEU A 457 REMARK 465 SER A 458 REMARK 465 PHE A 459 REMARK 465 THR A 460 REMARK 465 VAL A 461 REMARK 465 VAL A 462 REMARK 465 SER A 463 REMARK 465 THR A 464 REMARK 465 HIS A 465 REMARK 465 HIS A 466 REMARK 465 GLN A 467 REMARK 465 ASP A 468 REMARK 465 THR A 469 REMARK 465 GLY A 470 REMARK 465 GLU A 471 REMARK 465 GLU A 472 REMARK 465 SER A 473 REMARK 465 ALA A 474 REMARK 465 SER A 475 REMARK 465 SER A 476 REMARK 465 GLY A 477 REMARK 465 LYS A 478 REMARK 465 LEU A 479 REMARK 465 GLY A 480 REMARK 465 LEU A 481 REMARK 465 ILE A 482 REMARK 465 THR A 483 REMARK 465 ASN A 484 REMARK 465 THR A 485 REMARK 465 ILE A 486 REMARK 465 ALA A 487 REMARK 465 GLY A 488 REMARK 465 VAL A 489 REMARK 465 ALA A 490 REMARK 465 GLY A 491 REMARK 465 LEU A 492 REMARK 465 ILE A 493 REMARK 465 THR A 494 REMARK 465 GLY A 495 REMARK 465 GLY A 496 REMARK 465 ARG A 497 REMARK 465 ARG A 498 REMARK 465 THR A 499 REMARK 465 ARG A 500 REMARK 465 ARG A 501 REMARK 465 GLU A 502 REMARK 465 ASP A 614 REMARK 465 TRP A 615 REMARK 465 THR A 616 REMARK 465 LYS A 617 REMARK 465 ASN A 618 REMARK 465 ILE A 619 REMARK 465 THR A 620 REMARK 465 ASP A 621 REMARK 465 LYS A 622 REMARK 465 ILE A 623 REMARK 465 ASP A 624 REMARK 465 GLN A 625 REMARK 465 ILE A 626 REMARK 465 ILE A 627 REMARK 465 HIS A 628 REMARK 465 ASP A 629 REMARK 465 PHE A 630 REMARK 465 VAL A 631 REMARK 465 ASP A 632 REMARK 465 GLY A 633 REMARK 465 SER A 634 REMARK 465 GLY A 635 REMARK 465 TYR A 636 REMARK 465 ILE A 637 REMARK 465 PRO A 638 REMARK 465 GLU A 639 REMARK 465 ALA A 640 REMARK 465 PRO A 641 REMARK 465 ARG A 642 REMARK 465 ASP A 643 REMARK 465 GLY A 644 REMARK 465 GLN A 645 REMARK 465 ALA A 646 REMARK 465 TYR A 647 REMARK 465 VAL A 648 REMARK 465 ARG A 649 REMARK 465 LYS A 650 REMARK 465 ASP A 651 REMARK 465 GLY A 652 REMARK 465 GLU A 653 REMARK 465 TRP A 654 REMARK 465 VAL A 655 REMARK 465 LEU A 656 REMARK 465 LEU A 657 REMARK 465 SER A 658 REMARK 465 THR A 659 REMARK 465 PHE A 660 REMARK 465 LEU A 661 REMARK 465 GLY A 662 REMARK 465 HIS A 663 REMARK 465 HIS A 664 REMARK 465 HIS A 665 REMARK 465 HIS A 666 REMARK 465 HIS A 667 REMARK 465 HIS A 668 REMARK 465 MET B 9 REMARK 465 ASP B 10 REMARK 465 ALA B 11 REMARK 465 MET B 12 REMARK 465 LYS B 13 REMARK 465 ARG B 14 REMARK 465 GLY B 15 REMARK 465 LEU B 16 REMARK 465 CYS B 17 REMARK 465 CYS B 18 REMARK 465 VAL B 19 REMARK 465 LEU B 20 REMARK 465 LEU B 21 REMARK 465 LEU B 22 REMARK 465 CYS B 23 REMARK 465 GLY B 24 REMARK 465 ALA B 25 REMARK 465 VAL B 26 REMARK 465 PHE B 27 REMARK 465 VAL B 28 REMARK 465 SER B 29 REMARK 465 ALA B 30 REMARK 465 SER B 31 REMARK 465 LEU B 199 REMARK 465 ARG B 200 REMARK 465 GLU B 201 REMARK 465 PRO B 202 REMARK 465 VAL B 203 REMARK 465 ASN B 204 REMARK 465 ALA B 205 REMARK 465 THR B 206 REMARK 465 GLU B 207 REMARK 465 ASP B 208 REMARK 465 PRO B 209 REMARK 465 SER B 210 REMARK 465 SER B 211 REMARK 465 ILE B 436 REMARK 465 GLY B 437 REMARK 465 GLU B 438 REMARK 465 TRP B 439 REMARK 465 ALA B 440 REMARK 465 PHE B 441 REMARK 465 TRP B 442 REMARK 465 GLU B 443 REMARK 465 THR B 444 REMARK 465 LYS B 445 REMARK 465 LYS B 446 REMARK 465 ASN B 447 REMARK 465 LEU B 448 REMARK 465 THR B 449 REMARK 465 ARG B 450 REMARK 465 LYS B 451 REMARK 465 ILE B 452 REMARK 465 ARG B 453 REMARK 465 SER B 454 REMARK 465 GLU B 455 REMARK 465 GLU B 456 REMARK 465 LEU B 457 REMARK 465 SER B 458 REMARK 465 PHE B 459 REMARK 465 THR B 460 REMARK 465 VAL B 461 REMARK 465 VAL B 462 REMARK 465 SER B 463 REMARK 465 THR B 464 REMARK 465 HIS B 465 REMARK 465 HIS B 466 REMARK 465 GLN B 467 REMARK 465 ASP B 468 REMARK 465 THR B 469 REMARK 465 GLY B 470 REMARK 465 GLU B 471 REMARK 465 GLU B 472 REMARK 465 SER B 473 REMARK 465 ALA B 474 REMARK 465 SER B 475 REMARK 465 SER B 476 REMARK 465 GLY B 477 REMARK 465 LYS B 478 REMARK 465 LEU B 479 REMARK 465 GLY B 480 REMARK 465 LEU B 481 REMARK 465 ILE B 482 REMARK 465 THR B 483 REMARK 465 ASN B 484 REMARK 465 THR B 485 REMARK 465 ILE B 486 REMARK 465 ALA B 487 REMARK 465 GLY B 488 REMARK 465 VAL B 489 REMARK 465 ALA B 490 REMARK 465 GLY B 491 REMARK 465 LEU B 492 REMARK 465 ILE B 493 REMARK 465 THR B 494 REMARK 465 GLY B 495 REMARK 465 GLY B 496 REMARK 465 ARG B 497 REMARK 465 ARG B 498 REMARK 465 THR B 499 REMARK 465 ARG B 500 REMARK 465 ARG B 501 REMARK 465 GLU B 502 REMARK 465 ASP B 614 REMARK 465 TRP B 615 REMARK 465 THR B 616 REMARK 465 LYS B 617 REMARK 465 ASN B 618 REMARK 465 ILE B 619 REMARK 465 THR B 620 REMARK 465 ASP B 621 REMARK 465 LYS B 622 REMARK 465 ILE B 623 REMARK 465 ASP B 624 REMARK 465 GLN B 625 REMARK 465 ILE B 626 REMARK 465 ILE B 627 REMARK 465 HIS B 628 REMARK 465 ASP B 629 REMARK 465 PHE B 630 REMARK 465 VAL B 631 REMARK 465 ASP B 632 REMARK 465 GLY B 633 REMARK 465 SER B 634 REMARK 465 GLY B 635 REMARK 465 TYR B 636 REMARK 465 ILE B 637 REMARK 465 PRO B 638 REMARK 465 GLU B 639 REMARK 465 ALA B 640 REMARK 465 PRO B 641 REMARK 465 ARG B 642 REMARK 465 ASP B 643 REMARK 465 GLY B 644 REMARK 465 GLN B 645 REMARK 465 ALA B 646 REMARK 465 TYR B 647 REMARK 465 VAL B 648 REMARK 465 ARG B 649 REMARK 465 LYS B 650 REMARK 465 ASP B 651 REMARK 465 GLY B 652 REMARK 465 GLU B 653 REMARK 465 TRP B 654 REMARK 465 VAL B 655 REMARK 465 LEU B 656 REMARK 465 LEU B 657 REMARK 465 SER B 658 REMARK 465 THR B 659 REMARK 465 PHE B 660 REMARK 465 LEU B 661 REMARK 465 GLY B 662 REMARK 465 HIS B 663 REMARK 465 HIS B 664 REMARK 465 HIS B 665 REMARK 465 HIS B 666 REMARK 465 HIS B 667 REMARK 465 HIS B 668 REMARK 465 MET C 9 REMARK 465 ASP C 10 REMARK 465 ALA C 11 REMARK 465 MET C 12 REMARK 465 LYS C 13 REMARK 465 ARG C 14 REMARK 465 GLY C 15 REMARK 465 LEU C 16 REMARK 465 CYS C 17 REMARK 465 CYS C 18 REMARK 465 VAL C 19 REMARK 465 LEU C 20 REMARK 465 LEU C 21 REMARK 465 LEU C 22 REMARK 465 CYS C 23 REMARK 465 GLY C 24 REMARK 465 ALA C 25 REMARK 465 VAL C 26 REMARK 465 PHE C 27 REMARK 465 VAL C 28 REMARK 465 SER C 29 REMARK 465 ALA C 30 REMARK 465 SER C 31 REMARK 465 LEU C 199 REMARK 465 ARG C 200 REMARK 465 GLU C 201 REMARK 465 PRO C 202 REMARK 465 VAL C 203 REMARK 465 ASN C 204 REMARK 465 ALA C 205 REMARK 465 THR C 206 REMARK 465 GLU C 207 REMARK 465 ASP C 208 REMARK 465 PRO C 209 REMARK 465 SER C 210 REMARK 465 SER C 211 REMARK 465 SER C 263 REMARK 465 GLY C 264 REMARK 465 LYS C 265 REMARK 465 ARG C 266 REMARK 465 SER C 267 REMARK 465 ASN C 268 REMARK 465 THR C 269 REMARK 465 THR C 270 REMARK 465 GLU C 431 REMARK 465 ILE C 432 REMARK 465 ASP C 433 REMARK 465 THR C 434 REMARK 465 THR C 435 REMARK 465 ILE C 436 REMARK 465 GLY C 437 REMARK 465 GLU C 438 REMARK 465 TRP C 439 REMARK 465 ALA C 440 REMARK 465 PHE C 441 REMARK 465 TRP C 442 REMARK 465 GLU C 443 REMARK 465 THR C 444 REMARK 465 LYS C 445 REMARK 465 LYS C 446 REMARK 465 ASN C 447 REMARK 465 LEU C 448 REMARK 465 THR C 449 REMARK 465 ARG C 450 REMARK 465 LYS C 451 REMARK 465 ILE C 452 REMARK 465 ARG C 453 REMARK 465 SER C 454 REMARK 465 GLU C 455 REMARK 465 GLU C 456 REMARK 465 LEU C 457 REMARK 465 SER C 458 REMARK 465 PHE C 459 REMARK 465 THR C 460 REMARK 465 VAL C 461 REMARK 465 VAL C 462 REMARK 465 SER C 463 REMARK 465 THR C 464 REMARK 465 HIS C 465 REMARK 465 HIS C 466 REMARK 465 GLN C 467 REMARK 465 ASP C 468 REMARK 465 THR C 469 REMARK 465 GLY C 470 REMARK 465 GLU C 471 REMARK 465 GLU C 472 REMARK 465 SER C 473 REMARK 465 ALA C 474 REMARK 465 SER C 475 REMARK 465 SER C 476 REMARK 465 GLY C 477 REMARK 465 LYS C 478 REMARK 465 LEU C 479 REMARK 465 GLY C 480 REMARK 465 LEU C 481 REMARK 465 ILE C 482 REMARK 465 THR C 483 REMARK 465 ASN C 484 REMARK 465 THR C 485 REMARK 465 ILE C 486 REMARK 465 ALA C 487 REMARK 465 GLY C 488 REMARK 465 VAL C 489 REMARK 465 ALA C 490 REMARK 465 GLY C 491 REMARK 465 LEU C 492 REMARK 465 ILE C 493 REMARK 465 THR C 494 REMARK 465 GLY C 495 REMARK 465 GLY C 496 REMARK 465 ARG C 497 REMARK 465 ARG C 498 REMARK 465 THR C 499 REMARK 465 ARG C 500 REMARK 465 ARG C 501 REMARK 465 GLU C 502 REMARK 465 ASP C 614 REMARK 465 TRP C 615 REMARK 465 THR C 616 REMARK 465 LYS C 617 REMARK 465 ASN C 618 REMARK 465 ILE C 619 REMARK 465 THR C 620 REMARK 465 ASP C 621 REMARK 465 LYS C 622 REMARK 465 ILE C 623 REMARK 465 ASP C 624 REMARK 465 GLN C 625 REMARK 465 ILE C 626 REMARK 465 ILE C 627 REMARK 465 HIS C 628 REMARK 465 ASP C 629 REMARK 465 PHE C 630 REMARK 465 VAL C 631 REMARK 465 ASP C 632 REMARK 465 GLY C 633 REMARK 465 SER C 634 REMARK 465 GLY C 635 REMARK 465 TYR C 636 REMARK 465 ILE C 637 REMARK 465 PRO C 638 REMARK 465 GLU C 639 REMARK 465 ALA C 640 REMARK 465 PRO C 641 REMARK 465 ARG C 642 REMARK 465 ASP C 643 REMARK 465 GLY C 644 REMARK 465 GLN C 645 REMARK 465 ALA C 646 REMARK 465 TYR C 647 REMARK 465 VAL C 648 REMARK 465 ARG C 649 REMARK 465 LYS C 650 REMARK 465 ASP C 651 REMARK 465 GLY C 652 REMARK 465 GLU C 653 REMARK 465 TRP C 654 REMARK 465 VAL C 655 REMARK 465 LEU C 656 REMARK 465 LEU C 657 REMARK 465 SER C 658 REMARK 465 THR C 659 REMARK 465 PHE C 660 REMARK 465 LEU C 661 REMARK 465 GLY C 662 REMARK 465 HIS C 663 REMARK 465 HIS C 664 REMARK 465 HIS C 665 REMARK 465 HIS C 666 REMARK 465 HIS C 667 REMARK 465 HIS C 668 REMARK 465 GLY D 123 REMARK 465 GLY D 124 REMARK 465 GLN D 125 REMARK 465 HIS D 126 REMARK 465 HIS D 127 REMARK 465 HIS D 128 REMARK 465 HIS D 129 REMARK 465 HIS D 130 REMARK 465 HIS D 131 REMARK 465 GLY D 132 REMARK 465 ALA D 133 REMARK 465 TYR D 134 REMARK 465 PRO D 135 REMARK 465 TYR D 136 REMARK 465 ASP D 137 REMARK 465 VAL D 138 REMARK 465 PRO D 139 REMARK 465 ASP D 140 REMARK 465 TYR D 141 REMARK 465 ALA D 142 REMARK 465 SER D 143 REMARK 465 GLY E 123 REMARK 465 GLY E 124 REMARK 465 GLN E 125 REMARK 465 HIS E 126 REMARK 465 HIS E 127 REMARK 465 HIS E 128 REMARK 465 HIS E 129 REMARK 465 HIS E 130 REMARK 465 HIS E 131 REMARK 465 GLY E 132 REMARK 465 ALA E 133 REMARK 465 TYR E 134 REMARK 465 PRO E 135 REMARK 465 TYR E 136 REMARK 465 ASP E 137 REMARK 465 VAL E 138 REMARK 465 PRO E 139 REMARK 465 ASP E 140 REMARK 465 TYR E 141 REMARK 465 ALA E 142 REMARK 465 SER E 143 REMARK 465 GLY F 123 REMARK 465 GLY F 124 REMARK 465 GLN F 125 REMARK 465 HIS F 126 REMARK 465 HIS F 127 REMARK 465 HIS F 128 REMARK 465 HIS F 129 REMARK 465 HIS F 130 REMARK 465 HIS F 131 REMARK 465 GLY F 132 REMARK 465 ALA F 133 REMARK 465 TYR F 134 REMARK 465 PRO F 135 REMARK 465 TYR F 136 REMARK 465 ASP F 137 REMARK 465 VAL F 138 REMARK 465 PRO F 139 REMARK 465 ASP F 140 REMARK 465 TYR F 141 REMARK 465 ALA F 142 REMARK 465 SER F 143 REMARK 465 GLY G 124 REMARK 465 GLY G 125 REMARK 465 GLN G 126 REMARK 465 HIS G 127 REMARK 465 HIS G 128 REMARK 465 HIS G 129 REMARK 465 HIS G 130 REMARK 465 HIS G 131 REMARK 465 HIS G 132 REMARK 465 GLY G 133 REMARK 465 ALA G 134 REMARK 465 TYR G 135 REMARK 465 PRO G 136 REMARK 465 TYR G 137 REMARK 465 ASP G 138 REMARK 465 VAL G 139 REMARK 465 PRO G 140 REMARK 465 ASP G 141 REMARK 465 TYR G 142 REMARK 465 ALA G 143 REMARK 465 SER G 144 REMARK 465 GLY H 124 REMARK 465 GLY H 125 REMARK 465 GLN H 126 REMARK 465 HIS H 127 REMARK 465 HIS H 128 REMARK 465 HIS H 129 REMARK 465 HIS H 130 REMARK 465 HIS H 131 REMARK 465 HIS H 132 REMARK 465 GLY H 133 REMARK 465 ALA H 134 REMARK 465 TYR H 135 REMARK 465 PRO H 136 REMARK 465 TYR H 137 REMARK 465 ASP H 138 REMARK 465 VAL H 139 REMARK 465 PRO H 140 REMARK 465 ASP H 141 REMARK 465 TYR H 142 REMARK 465 ALA H 143 REMARK 465 SER H 144 REMARK 465 GLY I 124 REMARK 465 GLY I 125 REMARK 465 GLN I 126 REMARK 465 HIS I 127 REMARK 465 HIS I 128 REMARK 465 HIS I 129 REMARK 465 HIS I 130 REMARK 465 HIS I 131 REMARK 465 HIS I 132 REMARK 465 GLY I 133 REMARK 465 ALA I 134 REMARK 465 TYR I 135 REMARK 465 PRO I 136 REMARK 465 TYR I 137 REMARK 465 ASP I 138 REMARK 465 VAL I 139 REMARK 465 PRO I 140 REMARK 465 ASP I 141 REMARK 465 TYR I 142 REMARK 465 ALA I 143 REMARK 465 SER I 144 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASP A 163 70.38 57.47 REMARK 500 ASP A 192 -36.34 -131.47 REMARK 500 SER A 195 -166.14 -119.44 REMARK 500 HIS A 197 106.69 -34.41 REMARK 500 ASP A 237 -159.50 -147.37 REMARK 500 SER A 263 -37.21 -131.68 REMARK 500 LYS A 265 -10.66 73.30 REMARK 500 THR A 270 70.85 59.25 REMARK 500 ILE A 281 -107.07 54.69 REMARK 500 CYS A 601 85.24 -165.32 REMARK 500 ILE A 603 -61.46 -160.02 REMARK 500 ASN B 40 53.65 38.56 REMARK 500 LYS B 50 -6.78 73.24 REMARK 500 ASP B 163 70.72 58.13 REMARK 500 SER B 196 -119.97 31.53 REMARK 500 GLU B 523 -169.49 -129.68 REMARK 500 ALA B 525 15.57 59.99 REMARK 500 PHE B 535 51.58 -96.99 REMARK 500 ALA B 538 -168.65 -78.94 REMARK 500 ASN B 550 -0.66 67.01 REMARK 500 ARG C 134 61.17 63.40 REMARK 500 ASP C 163 70.02 55.20 REMARK 500 SER C 196 -167.95 62.63 REMARK 500 ILE C 527 132.42 73.25 REMARK 500 PHE C 535 52.43 -96.89 REMARK 500 ASN C 550 -66.20 61.88 REMARK 500 THR D 28 28.01 43.02 REMARK 500 VAL D 55 78.35 57.41 REMARK 500 ASN D 74 -70.90 64.35 REMARK 500 TYR D 109 -2.66 64.22 REMARK 500 TYR E 32 -61.01 -93.86 REMARK 500 VAL E 55 76.44 56.95 REMARK 500 PRO E 88 0.15 -69.77 REMARK 500 TYR E 107 81.88 60.45 REMARK 500 TYR E 109 -1.85 65.99 REMARK 500 VAL F 48 -62.79 -122.81 REMARK 500 VAL F 55 75.91 57.14 REMARK 500 ASN F 74 -72.20 63.51 REMARK 500 TYR F 109 -11.19 70.44 REMARK 500 TRP G 101 -38.02 -133.45 REMARK 500 ALA H 48 -52.88 -120.04 REMARK 500 LEU H 86 96.76 -66.86 REMARK 500 TRP H 101 107.33 -47.13 REMARK 500 SER H 102 -172.52 176.99 REMARK 500 TRP I 101 -71.62 65.86 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-71328 RELATED DB: EMDB REMARK 900 STRUCTURE OF EBOV GLYCOPROTEIN IN COMPLEX WITH NANOSOTA-EB1 AND EB2 DBREF 9P6X A 32 463 UNP Q05320 VGP_EBOZM 32 312 DBREF 9P6X A 464 632 UNP Q05320 VGP_EBOZM 464 632 DBREF 9P6X B 32 463 UNP Q05320 VGP_EBOZM 32 312 DBREF 9P6X B 464 632 UNP Q05320 VGP_EBOZM 464 632 DBREF 9P6X C 32 463 UNP Q05320 VGP_EBOZM 32 312 DBREF 9P6X C 464 632 UNP Q05320 VGP_EBOZM 464 632 DBREF 9P6X D 1 143 PDB 9P6X 9P6X 1 143 DBREF 9P6X E 1 143 PDB 9P6X 9P6X 1 143 DBREF 9P6X F 1 143 PDB 9P6X 9P6X 1 143 DBREF 9P6X G 2 144 PDB 9P6X 9P6X 2 144 DBREF 9P6X H 2 144 PDB 9P6X 9P6X 2 144 DBREF 9P6X I 2 144 PDB 9P6X 9P6X 2 144 SEQADV 9P6X MET A 9 UNP Q05320 INITIATING METHIONINE SEQADV 9P6X ASP A 10 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA A 11 UNP Q05320 EXPRESSION TAG SEQADV 9P6X MET A 12 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LYS A 13 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG A 14 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY A 15 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU A 16 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS A 17 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS A 18 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL A 19 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU A 20 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU A 21 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU A 22 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS A 23 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY A 24 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA A 25 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL A 26 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PHE A 27 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL A 28 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER A 29 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA A 30 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER A 31 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY A 633 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER A 634 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY A 635 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TYR A 636 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ILE A 637 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PRO A 638 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLU A 639 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA A 640 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PRO A 641 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG A 642 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ASP A 643 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY A 644 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLN A 645 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA A 646 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TYR A 647 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL A 648 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG A 649 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LYS A 650 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ASP A 651 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY A 652 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLU A 653 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TRP A 654 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL A 655 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU A 656 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU A 657 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER A 658 UNP Q05320 EXPRESSION TAG SEQADV 9P6X THR A 659 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PHE A 660 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU A 661 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY A 662 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS A 663 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS A 664 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS A 665 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS A 666 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS A 667 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS A 668 UNP Q05320 EXPRESSION TAG SEQADV 9P6X MET B 9 UNP Q05320 INITIATING METHIONINE SEQADV 9P6X ASP B 10 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA B 11 UNP Q05320 EXPRESSION TAG SEQADV 9P6X MET B 12 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LYS B 13 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG B 14 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY B 15 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU B 16 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS B 17 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS B 18 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL B 19 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU B 20 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU B 21 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU B 22 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS B 23 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY B 24 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA B 25 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL B 26 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PHE B 27 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL B 28 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER B 29 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA B 30 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER B 31 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY B 633 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER B 634 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY B 635 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TYR B 636 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ILE B 637 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PRO B 638 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLU B 639 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA B 640 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PRO B 641 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG B 642 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ASP B 643 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY B 644 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLN B 645 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA B 646 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TYR B 647 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL B 648 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG B 649 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LYS B 650 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ASP B 651 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY B 652 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLU B 653 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TRP B 654 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL B 655 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU B 656 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU B 657 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER B 658 UNP Q05320 EXPRESSION TAG SEQADV 9P6X THR B 659 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PHE B 660 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU B 661 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY B 662 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS B 663 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS B 664 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS B 665 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS B 666 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS B 667 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS B 668 UNP Q05320 EXPRESSION TAG SEQADV 9P6X MET C 9 UNP Q05320 INITIATING METHIONINE SEQADV 9P6X ASP C 10 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA C 11 UNP Q05320 EXPRESSION TAG SEQADV 9P6X MET C 12 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LYS C 13 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG C 14 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY C 15 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU C 16 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS C 17 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS C 18 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL C 19 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU C 20 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU C 21 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU C 22 UNP Q05320 EXPRESSION TAG SEQADV 9P6X CYS C 23 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY C 24 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA C 25 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL C 26 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PHE C 27 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL C 28 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER C 29 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA C 30 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER C 31 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY C 633 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER C 634 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY C 635 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TYR C 636 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ILE C 637 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PRO C 638 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLU C 639 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA C 640 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PRO C 641 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG C 642 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ASP C 643 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY C 644 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLN C 645 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ALA C 646 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TYR C 647 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL C 648 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ARG C 649 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LYS C 650 UNP Q05320 EXPRESSION TAG SEQADV 9P6X ASP C 651 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY C 652 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLU C 653 UNP Q05320 EXPRESSION TAG SEQADV 9P6X TRP C 654 UNP Q05320 EXPRESSION TAG SEQADV 9P6X VAL C 655 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU C 656 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU C 657 UNP Q05320 EXPRESSION TAG SEQADV 9P6X SER C 658 UNP Q05320 EXPRESSION TAG SEQADV 9P6X THR C 659 UNP Q05320 EXPRESSION TAG SEQADV 9P6X PHE C 660 UNP Q05320 EXPRESSION TAG SEQADV 9P6X LEU C 661 UNP Q05320 EXPRESSION TAG SEQADV 9P6X GLY C 662 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS C 663 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS C 664 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS C 665 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS C 666 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS C 667 UNP Q05320 EXPRESSION TAG SEQADV 9P6X HIS C 668 UNP Q05320 EXPRESSION TAG SEQRES 1 A 509 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 A 509 LEU CYS GLY ALA VAL PHE VAL SER ALA SER SER ILE PRO SEQRES 3 A 509 LEU GLY VAL ILE HIS ASN SER THR LEU GLN VAL SER ASP SEQRES 4 A 509 VAL ASP LYS LEU VAL CYS ARG ASP LYS LEU SER SER THR SEQRES 5 A 509 ASN GLN LEU ARG SER VAL GLY LEU ASN LEU GLU GLY ASN SEQRES 6 A 509 GLY VAL ALA THR ASP VAL PRO SER ALA THR LYS ARG TRP SEQRES 7 A 509 GLY PHE ARG SER GLY VAL PRO PRO LYS VAL VAL ASN TYR SEQRES 8 A 509 GLU ALA GLY GLU TRP ALA GLU ASN CYS TYR ASN LEU GLU SEQRES 9 A 509 ILE LYS LYS PRO ASP GLY SER GLU CYS LEU PRO ALA ALA SEQRES 10 A 509 PRO ASP GLY ILE ARG GLY PHE PRO ARG CYS ARG TYR VAL SEQRES 11 A 509 HIS LYS VAL SER GLY THR GLY PRO CYS ALA GLY ASP PHE SEQRES 12 A 509 ALA PHE HIS LYS GLU GLY ALA PHE PHE LEU TYR ASP ARG SEQRES 13 A 509 LEU ALA SER THR VAL ILE TYR ARG GLY THR THR PHE ALA SEQRES 14 A 509 GLU GLY VAL VAL ALA PHE LEU ILE LEU PRO GLN ALA LYS SEQRES 15 A 509 LYS ASP PHE PHE SER SER HIS PRO LEU ARG GLU PRO VAL SEQRES 16 A 509 ASN ALA THR GLU ASP PRO SER SER GLY TYR TYR SER THR SEQRES 17 A 509 THR ILE ARG TYR GLN ALA THR GLY PHE GLY THR ASN GLU SEQRES 18 A 509 THR GLU TYR LEU PHE GLU VAL ASP ASN LEU THR TYR VAL SEQRES 19 A 509 GLN LEU GLU SER ARG PHE THR PRO GLN PHE LEU LEU GLN SEQRES 20 A 509 LEU ASN GLU THR ILE TYR THR SER GLY LYS ARG SER ASN SEQRES 21 A 509 THR THR GLY LYS LEU ILE TRP LYS VAL ASN PRO GLU ILE SEQRES 22 A 509 ASP THR THR ILE GLY GLU TRP ALA PHE TRP GLU THR LYS SEQRES 23 A 509 LYS ASN LEU THR ARG LYS ILE ARG SER GLU GLU LEU SER SEQRES 24 A 509 PHE THR VAL VAL SER THR HIS HIS GLN ASP THR GLY GLU SEQRES 25 A 509 GLU SER ALA SER SER GLY LYS LEU GLY LEU ILE THR ASN SEQRES 26 A 509 THR ILE ALA GLY VAL ALA GLY LEU ILE THR GLY GLY ARG SEQRES 27 A 509 ARG THR ARG ARG GLU ALA ILE VAL ASN ALA GLN PRO LYS SEQRES 28 A 509 CYS ASN PRO ASN LEU HIS TYR TRP THR THR GLN ASP GLU SEQRES 29 A 509 GLY ALA ALA ILE GLY LEU ALA TRP ILE PRO TYR PHE GLY SEQRES 30 A 509 PRO ALA ALA GLU GLY ILE TYR ILE GLU GLY LEU MET HIS SEQRES 31 A 509 ASN GLN ASP GLY LEU ILE CYS GLY LEU ARG GLN LEU ALA SEQRES 32 A 509 ASN GLU THR THR GLN ALA LEU GLN LEU PHE LEU ARG ALA SEQRES 33 A 509 THR THR GLU LEU ARG THR PHE SER ILE LEU ASN ARG LYS SEQRES 34 A 509 ALA ILE ASP PHE LEU LEU GLN ARG TRP GLY GLY THR CYS SEQRES 35 A 509 HIS ILE LEU GLY PRO ASP CYS CYS ILE GLU PRO HIS ASP SEQRES 36 A 509 TRP THR LYS ASN ILE THR ASP LYS ILE ASP GLN ILE ILE SEQRES 37 A 509 HIS ASP PHE VAL ASP GLY SER GLY TYR ILE PRO GLU ALA SEQRES 38 A 509 PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU SEQRES 39 A 509 TRP VAL LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS SEQRES 40 A 509 HIS HIS SEQRES 1 B 509 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 B 509 LEU CYS GLY ALA VAL PHE VAL SER ALA SER SER ILE PRO SEQRES 3 B 509 LEU GLY VAL ILE HIS ASN SER THR LEU GLN VAL SER ASP SEQRES 4 B 509 VAL ASP LYS LEU VAL CYS ARG ASP LYS LEU SER SER THR SEQRES 5 B 509 ASN GLN LEU ARG SER VAL GLY LEU ASN LEU GLU GLY ASN SEQRES 6 B 509 GLY VAL ALA THR ASP VAL PRO SER ALA THR LYS ARG TRP SEQRES 7 B 509 GLY PHE ARG SER GLY VAL PRO PRO LYS VAL VAL ASN TYR SEQRES 8 B 509 GLU ALA GLY GLU TRP ALA GLU ASN CYS TYR ASN LEU GLU SEQRES 9 B 509 ILE LYS LYS PRO ASP GLY SER GLU CYS LEU PRO ALA ALA SEQRES 10 B 509 PRO ASP GLY ILE ARG GLY PHE PRO ARG CYS ARG TYR VAL SEQRES 11 B 509 HIS LYS VAL SER GLY THR GLY PRO CYS ALA GLY ASP PHE SEQRES 12 B 509 ALA PHE HIS LYS GLU GLY ALA PHE PHE LEU TYR ASP ARG SEQRES 13 B 509 LEU ALA SER THR VAL ILE TYR ARG GLY THR THR PHE ALA SEQRES 14 B 509 GLU GLY VAL VAL ALA PHE LEU ILE LEU PRO GLN ALA LYS SEQRES 15 B 509 LYS ASP PHE PHE SER SER HIS PRO LEU ARG GLU PRO VAL SEQRES 16 B 509 ASN ALA THR GLU ASP PRO SER SER GLY TYR TYR SER THR SEQRES 17 B 509 THR ILE ARG TYR GLN ALA THR GLY PHE GLY THR ASN GLU SEQRES 18 B 509 THR GLU TYR LEU PHE GLU VAL ASP ASN LEU THR TYR VAL SEQRES 19 B 509 GLN LEU GLU SER ARG PHE THR PRO GLN PHE LEU LEU GLN SEQRES 20 B 509 LEU ASN GLU THR ILE TYR THR SER GLY LYS ARG SER ASN SEQRES 21 B 509 THR THR GLY LYS LEU ILE TRP LYS VAL ASN PRO GLU ILE SEQRES 22 B 509 ASP THR THR ILE GLY GLU TRP ALA PHE TRP GLU THR LYS SEQRES 23 B 509 LYS ASN LEU THR ARG LYS ILE ARG SER GLU GLU LEU SER SEQRES 24 B 509 PHE THR VAL VAL SER THR HIS HIS GLN ASP THR GLY GLU SEQRES 25 B 509 GLU SER ALA SER SER GLY LYS LEU GLY LEU ILE THR ASN SEQRES 26 B 509 THR ILE ALA GLY VAL ALA GLY LEU ILE THR GLY GLY ARG SEQRES 27 B 509 ARG THR ARG ARG GLU ALA ILE VAL ASN ALA GLN PRO LYS SEQRES 28 B 509 CYS ASN PRO ASN LEU HIS TYR TRP THR THR GLN ASP GLU SEQRES 29 B 509 GLY ALA ALA ILE GLY LEU ALA TRP ILE PRO TYR PHE GLY SEQRES 30 B 509 PRO ALA ALA GLU GLY ILE TYR ILE GLU GLY LEU MET HIS SEQRES 31 B 509 ASN GLN ASP GLY LEU ILE CYS GLY LEU ARG GLN LEU ALA SEQRES 32 B 509 ASN GLU THR THR GLN ALA LEU GLN LEU PHE LEU ARG ALA SEQRES 33 B 509 THR THR GLU LEU ARG THR PHE SER ILE LEU ASN ARG LYS SEQRES 34 B 509 ALA ILE ASP PHE LEU LEU GLN ARG TRP GLY GLY THR CYS SEQRES 35 B 509 HIS ILE LEU GLY PRO ASP CYS CYS ILE GLU PRO HIS ASP SEQRES 36 B 509 TRP THR LYS ASN ILE THR ASP LYS ILE ASP GLN ILE ILE SEQRES 37 B 509 HIS ASP PHE VAL ASP GLY SER GLY TYR ILE PRO GLU ALA SEQRES 38 B 509 PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU SEQRES 39 B 509 TRP VAL LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS SEQRES 40 B 509 HIS HIS SEQRES 1 C 509 MET ASP ALA MET LYS ARG GLY LEU CYS CYS VAL LEU LEU SEQRES 2 C 509 LEU CYS GLY ALA VAL PHE VAL SER ALA SER SER ILE PRO SEQRES 3 C 509 LEU GLY VAL ILE HIS ASN SER THR LEU GLN VAL SER ASP SEQRES 4 C 509 VAL ASP LYS LEU VAL CYS ARG ASP LYS LEU SER SER THR SEQRES 5 C 509 ASN GLN LEU ARG SER VAL GLY LEU ASN LEU GLU GLY ASN SEQRES 6 C 509 GLY VAL ALA THR ASP VAL PRO SER ALA THR LYS ARG TRP SEQRES 7 C 509 GLY PHE ARG SER GLY VAL PRO PRO LYS VAL VAL ASN TYR SEQRES 8 C 509 GLU ALA GLY GLU TRP ALA GLU ASN CYS TYR ASN LEU GLU SEQRES 9 C 509 ILE LYS LYS PRO ASP GLY SER GLU CYS LEU PRO ALA ALA SEQRES 10 C 509 PRO ASP GLY ILE ARG GLY PHE PRO ARG CYS ARG TYR VAL SEQRES 11 C 509 HIS LYS VAL SER GLY THR GLY PRO CYS ALA GLY ASP PHE SEQRES 12 C 509 ALA PHE HIS LYS GLU GLY ALA PHE PHE LEU TYR ASP ARG SEQRES 13 C 509 LEU ALA SER THR VAL ILE TYR ARG GLY THR THR PHE ALA SEQRES 14 C 509 GLU GLY VAL VAL ALA PHE LEU ILE LEU PRO GLN ALA LYS SEQRES 15 C 509 LYS ASP PHE PHE SER SER HIS PRO LEU ARG GLU PRO VAL SEQRES 16 C 509 ASN ALA THR GLU ASP PRO SER SER GLY TYR TYR SER THR SEQRES 17 C 509 THR ILE ARG TYR GLN ALA THR GLY PHE GLY THR ASN GLU SEQRES 18 C 509 THR GLU TYR LEU PHE GLU VAL ASP ASN LEU THR TYR VAL SEQRES 19 C 509 GLN LEU GLU SER ARG PHE THR PRO GLN PHE LEU LEU GLN SEQRES 20 C 509 LEU ASN GLU THR ILE TYR THR SER GLY LYS ARG SER ASN SEQRES 21 C 509 THR THR GLY LYS LEU ILE TRP LYS VAL ASN PRO GLU ILE SEQRES 22 C 509 ASP THR THR ILE GLY GLU TRP ALA PHE TRP GLU THR LYS SEQRES 23 C 509 LYS ASN LEU THR ARG LYS ILE ARG SER GLU GLU LEU SER SEQRES 24 C 509 PHE THR VAL VAL SER THR HIS HIS GLN ASP THR GLY GLU SEQRES 25 C 509 GLU SER ALA SER SER GLY LYS LEU GLY LEU ILE THR ASN SEQRES 26 C 509 THR ILE ALA GLY VAL ALA GLY LEU ILE THR GLY GLY ARG SEQRES 27 C 509 ARG THR ARG ARG GLU ALA ILE VAL ASN ALA GLN PRO LYS SEQRES 28 C 509 CYS ASN PRO ASN LEU HIS TYR TRP THR THR GLN ASP GLU SEQRES 29 C 509 GLY ALA ALA ILE GLY LEU ALA TRP ILE PRO TYR PHE GLY SEQRES 30 C 509 PRO ALA ALA GLU GLY ILE TYR ILE GLU GLY LEU MET HIS SEQRES 31 C 509 ASN GLN ASP GLY LEU ILE CYS GLY LEU ARG GLN LEU ALA SEQRES 32 C 509 ASN GLU THR THR GLN ALA LEU GLN LEU PHE LEU ARG ALA SEQRES 33 C 509 THR THR GLU LEU ARG THR PHE SER ILE LEU ASN ARG LYS SEQRES 34 C 509 ALA ILE ASP PHE LEU LEU GLN ARG TRP GLY GLY THR CYS SEQRES 35 C 509 HIS ILE LEU GLY PRO ASP CYS CYS ILE GLU PRO HIS ASP SEQRES 36 C 509 TRP THR LYS ASN ILE THR ASP LYS ILE ASP GLN ILE ILE SEQRES 37 C 509 HIS ASP PHE VAL ASP GLY SER GLY TYR ILE PRO GLU ALA SEQRES 38 C 509 PRO ARG ASP GLY GLN ALA TYR VAL ARG LYS ASP GLY GLU SEQRES 39 C 509 TRP VAL LEU LEU SER THR PHE LEU GLY HIS HIS HIS HIS SEQRES 40 C 509 HIS HIS SEQRES 1 D 143 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY GLN VAL GLN SEQRES 2 D 143 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 D 143 SER THR SER VAL ILE TYR ALA MET GLY TRP TYR ARG GLN SEQRES 4 D 143 ALA PRO GLY LYS GLN ARG GLU LEU VAL ALA ALA ILE THR SEQRES 5 D 143 ARG GLY VAL GLY SER THR ASN TYR ALA ASP SER VAL LYS SEQRES 6 D 143 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN THR SEQRES 7 D 143 MET TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP THR SEQRES 8 D 143 ALA VAL TYR TYR CYS ASN ALA ARG LEU LEU VAL ALA PRO SEQRES 9 D 143 PRO PRO TYR GLU TYR ASP TYR TRP GLY GLN GLY THR GLN SEQRES 10 D 143 VAL THR VAL SER SER GLY GLY GLN HIS HIS HIS HIS HIS SEQRES 11 D 143 HIS GLY ALA TYR PRO TYR ASP VAL PRO ASP TYR ALA SER SEQRES 1 E 143 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY GLN VAL GLN SEQRES 2 E 143 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 E 143 SER THR SER VAL ILE TYR ALA MET GLY TRP TYR ARG GLN SEQRES 4 E 143 ALA PRO GLY LYS GLN ARG GLU LEU VAL ALA ALA ILE THR SEQRES 5 E 143 ARG GLY VAL GLY SER THR ASN TYR ALA ASP SER VAL LYS SEQRES 6 E 143 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN THR SEQRES 7 E 143 MET TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP THR SEQRES 8 E 143 ALA VAL TYR TYR CYS ASN ALA ARG LEU LEU VAL ALA PRO SEQRES 9 E 143 PRO PRO TYR GLU TYR ASP TYR TRP GLY GLN GLY THR GLN SEQRES 10 E 143 VAL THR VAL SER SER GLY GLY GLN HIS HIS HIS HIS HIS SEQRES 11 E 143 HIS GLY ALA TYR PRO TYR ASP VAL PRO ASP TYR ALA SER SEQRES 1 F 143 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY GLN VAL GLN SEQRES 2 F 143 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY SEQRES 3 F 143 SER THR SER VAL ILE TYR ALA MET GLY TRP TYR ARG GLN SEQRES 4 F 143 ALA PRO GLY LYS GLN ARG GLU LEU VAL ALA ALA ILE THR SEQRES 5 F 143 ARG GLY VAL GLY SER THR ASN TYR ALA ASP SER VAL LYS SEQRES 6 F 143 GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN THR SEQRES 7 F 143 MET TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP THR SEQRES 8 F 143 ALA VAL TYR TYR CYS ASN ALA ARG LEU LEU VAL ALA PRO SEQRES 9 F 143 PRO PRO TYR GLU TYR ASP TYR TRP GLY GLN GLY THR GLN SEQRES 10 F 143 VAL THR VAL SER SER GLY GLY GLN HIS HIS HIS HIS HIS SEQRES 11 F 143 HIS GLY ALA TYR PRO TYR ASP VAL PRO ASP TYR ALA SER SEQRES 1 G 143 VAL GLN LEU GLN GLU SER GLY GLY GLY VAL VAL GLN ALA SEQRES 2 G 143 GLY GLY SER LEU ARG LEU SER CYS SER ALA SER GLY ARG SEQRES 3 G 143 THR PHE SER ASN TYR ALA MET ALA TRP PHE ARG GLN ALA SEQRES 4 G 143 PRO GLY LYS ASP ARG GLU PHE ALA ALA GLY ILE ASN TYR SEQRES 5 G 143 ASN GLY GLU ARG THR ALA TYR ALA ASP SER VAL LYS GLY SEQRES 6 G 143 ARG PHE THR ILE SER ARG ASP ASP ALA LYS ASN THR VAL SEQRES 7 G 143 TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP THR ALA SEQRES 8 G 143 VAL TYR SER CYS ALA ALA ARG PRO TRP SER ILE ALA ASN SEQRES 9 G 143 LEU ALA TYR THR TYR ASP SER TRP GLY GLN GLY THR GLN SEQRES 10 G 143 VAL THR VAL SER SER GLY GLY GLN HIS HIS HIS HIS HIS SEQRES 11 G 143 HIS GLY ALA TYR PRO TYR ASP VAL PRO ASP TYR ALA SER SEQRES 1 H 143 VAL GLN LEU GLN GLU SER GLY GLY GLY VAL VAL GLN ALA SEQRES 2 H 143 GLY GLY SER LEU ARG LEU SER CYS SER ALA SER GLY ARG SEQRES 3 H 143 THR PHE SER ASN TYR ALA MET ALA TRP PHE ARG GLN ALA SEQRES 4 H 143 PRO GLY LYS ASP ARG GLU PHE ALA ALA GLY ILE ASN TYR SEQRES 5 H 143 ASN GLY GLU ARG THR ALA TYR ALA ASP SER VAL LYS GLY SEQRES 6 H 143 ARG PHE THR ILE SER ARG ASP ASP ALA LYS ASN THR VAL SEQRES 7 H 143 TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP THR ALA SEQRES 8 H 143 VAL TYR SER CYS ALA ALA ARG PRO TRP SER ILE ALA ASN SEQRES 9 H 143 LEU ALA TYR THR TYR ASP SER TRP GLY GLN GLY THR GLN SEQRES 10 H 143 VAL THR VAL SER SER GLY GLY GLN HIS HIS HIS HIS HIS SEQRES 11 H 143 HIS GLY ALA TYR PRO TYR ASP VAL PRO ASP TYR ALA SER SEQRES 1 I 143 VAL GLN LEU GLN GLU SER GLY GLY GLY VAL VAL GLN ALA SEQRES 2 I 143 GLY GLY SER LEU ARG LEU SER CYS SER ALA SER GLY ARG SEQRES 3 I 143 THR PHE SER ASN TYR ALA MET ALA TRP PHE ARG GLN ALA SEQRES 4 I 143 PRO GLY LYS ASP ARG GLU PHE ALA ALA GLY ILE ASN TYR SEQRES 5 I 143 ASN GLY GLU ARG THR ALA TYR ALA ASP SER VAL LYS GLY SEQRES 6 I 143 ARG PHE THR ILE SER ARG ASP ASP ALA LYS ASN THR VAL SEQRES 7 I 143 TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP THR ALA SEQRES 8 I 143 VAL TYR SER CYS ALA ALA ARG PRO TRP SER ILE ALA ASN SEQRES 9 I 143 LEU ALA TYR THR TYR ASP SER TRP GLY GLN GLY THR GLN SEQRES 10 I 143 VAL THR VAL SER SER GLY GLY GLN HIS HIS HIS HIS HIS SEQRES 11 I 143 HIS GLY ALA TYR PRO TYR ASP VAL PRO ASP TYR ALA SER HET NAG J 1 14 HET NAG J 2 14 HET BMA J 3 11 HET MAN J 4 11 HET MAN J 5 11 HET MAN J 6 11 HET NAG K 1 14 HET NAG K 2 14 HET BMA K 3 11 HET MAN K 4 11 HET MAN K 5 11 HET MAN K 6 11 HET NAG L 1 14 HET NAG L 2 14 HET BMA L 3 11 HET MAN L 4 11 HET MAN L 5 11 HET NAG A 701 14 HET NAG B 701 14 HET NAG C 701 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE FORMUL 10 NAG 9(C8 H15 N O6) FORMUL 10 BMA 3(C6 H12 O6) FORMUL 10 MAN 8(C6 H12 O6) HELIX 1 AA1 SER A 59 ASN A 61 5 3 HELIX 2 AA2 GLU A 71 ASN A 73 5 3 HELIX 3 AA3 ASP A 78 THR A 83 1 6 HELIX 4 AA4 THR A 249 GLY A 264 1 16 HELIX 5 AA5 ASP A 552 THR A 576 1 25 HELIX 6 AA6 SER A 583 ARG A 596 1 14 HELIX 7 AA7 SER B 59 ASN B 61 5 3 HELIX 8 AA8 ASN B 69 GLY B 74 5 6 HELIX 9 AA9 ASP B 78 THR B 83 1 6 HELIX 10 AB1 THR B 249 GLY B 264 1 16 HELIX 11 AB2 ASP B 552 THR B 565 1 14 HELIX 12 AB3 THR B 565 THR B 576 1 12 HELIX 13 AB4 SER B 583 TRP B 597 1 15 HELIX 14 AB5 VAL C 52 LYS C 56 5 5 HELIX 15 AB6 GLU C 71 GLY C 74 5 4 HELIX 16 AB7 ASP C 78 THR C 83 1 6 HELIX 17 AB8 THR C 249 TYR C 261 1 13 HELIX 18 AB9 ASP C 552 THR C 565 1 14 HELIX 19 AC1 THR C 565 THR C 576 1 12 HELIX 20 AC2 SER C 583 TRP C 597 1 15 HELIX 21 AC3 ASP D 62 LYS D 65 5 4 HELIX 22 AC4 ASN D 74 ASN D 77 5 4 HELIX 23 AC5 LYS D 87 THR D 91 5 5 HELIX 24 AC6 LYS E 87 THR E 91 5 5 HELIX 25 AC7 ASP F 62 LYS F 65 5 4 HELIX 26 AC8 LYS F 87 THR F 91 5 5 HELIX 27 AC9 LYS G 87 THR G 91 5 5 HELIX 28 AD1 LEU G 106 TYR G 110 5 5 HELIX 29 AD2 LYS H 87 THR H 91 5 5 HELIX 30 AD3 LEU H 106 TYR H 110 5 5 HELIX 31 AD4 LYS I 87 THR I 91 5 5 HELIX 32 AD5 LEU I 106 TYR I 110 5 5 SHEET 1 AA1 4 THR A 42 VAL A 45 0 SHEET 2 AA1 4 GLY A 36 HIS A 39 -1 N VAL A 37 O GLN A 44 SHEET 3 AA1 4 ALA A 177 ILE A 185 1 O ILE A 185 N GLY A 36 SHEET 4 AA1 4 LEU A 63 ASN A 69 -1 N VAL A 66 O ALA A 182 SHEET 1 AA2 7 THR A 42 VAL A 45 0 SHEET 2 AA2 7 GLY A 36 HIS A 39 -1 N VAL A 37 O GLN A 44 SHEET 3 AA2 7 ALA A 177 ILE A 185 1 O ILE A 185 N GLY A 36 SHEET 4 AA2 7 PHE A 159 LEU A 161 -1 N PHE A 159 O GLY A 179 SHEET 5 AA2 7 LEU A 165 SER A 167 -1 O SER A 167 N PHE A 160 SHEET 6 AA2 7 VAL A 96 ASN A 98 -1 N VAL A 97 O ALA A 166 SHEET 7 AA2 7 ARG A 580 THR A 581 1 O THR A 581 N ASN A 98 SHEET 1 AA3 2 TRP A 86 ARG A 89 0 SHEET 2 AA3 2 PHE A 151 HIS A 154 -1 O PHE A 153 N GLY A 87 SHEET 1 AA4 7 ALA A 105 LYS A 114 0 SHEET 2 AA4 7 CYS A 135 THR A 144 1 O HIS A 139 N CYS A 108 SHEET 3 AA4 7 THR A 216 THR A 223 1 O TYR A 220 N LYS A 140 SHEET 4 AA4 7 GLU A 231 GLU A 235 -1 O GLU A 235 N ARG A 219 SHEET 5 AA4 7 THR A 240 GLN A 243 -1 O VAL A 242 N PHE A 234 SHEET 6 AA4 7 LEU A 273 VAL A 277 1 O TRP A 275 N GLN A 243 SHEET 7 AA4 7 VAL E 102 ALA E 103 -1 O ALA E 103 N LYS A 276 SHEET 1 AA5 2 TRP A 518 THR A 519 0 SHEET 2 AA5 2 ILE A 544 GLU A 545 -1 O ILE A 544 N THR A 519 SHEET 1 AA6 4 THR B 42 VAL B 45 0 SHEET 2 AA6 4 GLY B 36 HIS B 39 -1 N VAL B 37 O GLN B 44 SHEET 3 AA6 4 ALA B 182 ILE B 185 1 O ILE B 185 N GLY B 36 SHEET 4 AA6 4 LEU B 63 VAL B 66 -1 N ARG B 64 O LEU B 184 SHEET 1 AA7 2 TRP B 86 ARG B 89 0 SHEET 2 AA7 2 PHE B 151 HIS B 154 -1 O PHE B 153 N GLY B 87 SHEET 1 AA8 5 ALA B 177 GLY B 179 0 SHEET 2 AA8 5 PHE B 159 LEU B 161 -1 N LEU B 161 O ALA B 177 SHEET 3 AA8 5 LEU B 165 SER B 167 -1 O SER B 167 N PHE B 160 SHEET 4 AA8 5 VAL B 96 ASN B 98 -1 N VAL B 97 O ALA B 166 SHEET 5 AA8 5 ARG B 580 THR B 581 1 O THR B 581 N VAL B 96 SHEET 1 AA9 7 ALA B 105 LYS B 114 0 SHEET 2 AA9 7 CYS B 135 THR B 144 1 O HIS B 139 N CYS B 108 SHEET 3 AA9 7 THR B 216 THR B 223 1 O ALA B 222 N SER B 142 SHEET 4 AA9 7 GLU B 231 ASP B 237 -1 O GLU B 235 N ARG B 219 SHEET 5 AA9 7 THR B 240 GLN B 243 -1 O VAL B 242 N PHE B 234 SHEET 6 AA9 7 LEU B 273 VAL B 277 1 O TRP B 275 N GLN B 243 SHEET 7 AA9 7 VAL D 102 ALA D 103 -1 O ALA D 103 N LYS B 276 SHEET 1 AB1 2 TRP B 518 THR B 519 0 SHEET 2 AB1 2 ILE B 544 GLU B 545 -1 O ILE B 544 N THR B 519 SHEET 1 AB2 4 THR C 42 SER C 46 0 SHEET 2 AB2 4 LEU C 35 HIS C 39 -1 N VAL C 37 O GLN C 44 SHEET 3 AB2 4 ALA C 177 ILE C 185 1 O ILE C 185 N GLY C 36 SHEET 4 AB2 4 LEU C 63 ASN C 69 -1 N VAL C 66 O ALA C 182 SHEET 1 AB3 7 THR C 42 SER C 46 0 SHEET 2 AB3 7 LEU C 35 HIS C 39 -1 N VAL C 37 O GLN C 44 SHEET 3 AB3 7 ALA C 177 ILE C 185 1 O ILE C 185 N GLY C 36 SHEET 4 AB3 7 PHE C 159 LEU C 161 -1 N LEU C 161 O ALA C 177 SHEET 5 AB3 7 LEU C 165 SER C 167 -1 O SER C 167 N PHE C 160 SHEET 6 AB3 7 VAL C 96 ASN C 98 -1 N VAL C 97 O ALA C 166 SHEET 7 AB3 7 ARG C 580 THR C 581 1 O THR C 581 N VAL C 96 SHEET 1 AB4 2 TRP C 86 ARG C 89 0 SHEET 2 AB4 2 PHE C 151 HIS C 154 -1 O PHE C 153 N GLY C 87 SHEET 1 AB5 3 ALA C 101 GLU C 103 0 SHEET 2 AB5 3 TYR C 517 THR C 519 -1 O TRP C 518 N GLY C 102 SHEET 3 AB5 3 ILE C 544 GLU C 545 -1 O ILE C 544 N THR C 519 SHEET 1 AB6 7 ALA C 105 LYS C 114 0 SHEET 2 AB6 7 CYS C 135 THR C 144 1 O HIS C 139 N CYS C 108 SHEET 3 AB6 7 THR C 216 THR C 223 1 O TYR C 220 N LYS C 140 SHEET 4 AB6 7 GLU C 231 GLU C 235 -1 O LEU C 233 N GLN C 221 SHEET 5 AB6 7 THR C 240 GLN C 243 -1 O VAL C 242 N PHE C 234 SHEET 6 AB6 7 LEU C 273 VAL C 277 1 O LEU C 273 N TYR C 241 SHEET 7 AB6 7 VAL F 102 ALA F 103 -1 O ALA F 103 N LYS C 276 SHEET 1 AB7 4 LEU D 4 SER D 7 0 SHEET 2 AB7 4 LEU D 18 ALA D 24 -1 O ALA D 23 N GLN D 5 SHEET 3 AB7 4 MET D 79 MET D 83 -1 O LEU D 81 N LEU D 20 SHEET 4 AB7 4 PHE D 68 ARG D 72 -1 N THR D 69 O GLN D 82 SHEET 1 AB8 6 GLN D 11 GLN D 13 0 SHEET 2 AB8 6 THR D 116 SER D 121 1 O THR D 119 N VAL D 12 SHEET 3 AB8 6 ALA D 92 LEU D 100 -1 N ALA D 92 O VAL D 118 SHEET 4 AB8 6 ILE D 31 GLN D 39 -1 N TYR D 37 O TYR D 95 SHEET 5 AB8 6 ARG D 45 THR D 52 -1 O ILE D 51 N MET D 34 SHEET 6 AB8 6 THR D 58 TYR D 60 -1 O ASN D 59 N ALA D 50 SHEET 1 AB9 4 GLN E 5 SER E 7 0 SHEET 2 AB9 4 LEU E 18 ALA E 23 -1 O ALA E 23 N GLN E 5 SHEET 3 AB9 4 THR E 78 MET E 83 -1 O LEU E 81 N LEU E 20 SHEET 4 AB9 4 PHE E 68 ASP E 73 -1 N THR E 69 O GLN E 82 SHEET 1 AC1 6 GLN E 11 GLN E 13 0 SHEET 2 AC1 6 THR E 116 SER E 121 1 O THR E 119 N VAL E 12 SHEET 3 AC1 6 ALA E 92 LEU E 100 -1 N TYR E 94 O THR E 116 SHEET 4 AC1 6 ILE E 31 GLN E 39 -1 N TYR E 37 O TYR E 95 SHEET 5 AC1 6 GLU E 46 THR E 52 -1 O ALA E 49 N TRP E 36 SHEET 6 AC1 6 THR E 58 TYR E 60 -1 O ASN E 59 N ALA E 50 SHEET 1 AC2 4 GLN E 11 GLN E 13 0 SHEET 2 AC2 4 THR E 116 SER E 121 1 O THR E 119 N VAL E 12 SHEET 3 AC2 4 ALA E 92 LEU E 100 -1 N TYR E 94 O THR E 116 SHEET 4 AC2 4 ASP E 110 TYR E 111 -1 O TYR E 111 N ALA E 98 SHEET 1 AC3 4 VAL F 2 SER F 7 0 SHEET 2 AC3 4 LEU F 18 GLY F 26 -1 O ALA F 23 N GLN F 5 SHEET 3 AC3 4 MET F 79 MET F 83 -1 O MET F 83 N LEU F 18 SHEET 4 AC3 4 PHE F 68 ARG F 72 -1 N SER F 71 O TYR F 80 SHEET 1 AC4 6 GLY F 10 GLN F 13 0 SHEET 2 AC4 6 THR F 116 SER F 121 1 O THR F 119 N GLY F 10 SHEET 3 AC4 6 ALA F 92 LEU F 100 -1 N ALA F 92 O VAL F 118 SHEET 4 AC4 6 ILE F 31 GLN F 39 -1 N TYR F 37 O TYR F 95 SHEET 5 AC4 6 GLU F 46 THR F 52 -1 O ILE F 51 N MET F 34 SHEET 6 AC4 6 THR F 58 TYR F 60 -1 O ASN F 59 N ALA F 50 SHEET 1 AC5 4 LEU G 4 SER G 7 0 SHEET 2 AC5 4 LEU G 18 ALA G 24 -1 O SER G 21 N SER G 7 SHEET 3 AC5 4 THR G 78 MET G 83 -1 O MET G 83 N LEU G 18 SHEET 4 AC5 4 PHE G 68 ASP G 73 -1 N SER G 71 O TYR G 80 SHEET 1 AC6 2 VAL G 11 GLN G 13 0 SHEET 2 AC6 2 THR G 120 SER G 122 1 O THR G 120 N VAL G 12 SHEET 1 AC7 5 THR G 58 TYR G 60 0 SHEET 2 AC7 5 ARG G 45 ILE G 51 -1 N GLY G 50 O ALA G 59 SHEET 3 AC7 5 ALA G 33 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 4 AC7 5 VAL G 93 ARG G 99 -1 O SER G 95 N PHE G 37 SHEET 5 AC7 5 SER G 112 TRP G 113 -1 O SER G 112 N ALA G 98 SHEET 1 AC8 5 THR G 58 TYR G 60 0 SHEET 2 AC8 5 ARG G 45 ILE G 51 -1 N GLY G 50 O ALA G 59 SHEET 3 AC8 5 ALA G 33 GLN G 39 -1 N ARG G 38 O GLU G 46 SHEET 4 AC8 5 VAL G 93 ARG G 99 -1 O SER G 95 N PHE G 37 SHEET 5 AC8 5 THR G 117 GLN G 118 -1 O THR G 117 N TYR G 94 SHEET 1 AC9 4 GLN H 3 SER H 7 0 SHEET 2 AC9 4 SER H 17 SER H 25 -1 O SER H 25 N GLN H 3 SHEET 3 AC9 4 THR H 78 ASN H 84 -1 O MET H 83 N LEU H 18 SHEET 4 AC9 4 THR H 69 ASP H 73 -1 N THR H 69 O GLN H 82 SHEET 1 AD1 2 VAL H 11 GLN H 13 0 SHEET 2 AD1 2 THR H 120 SER H 122 1 O SER H 122 N VAL H 12 SHEET 1 AD2 5 THR H 58 TYR H 60 0 SHEET 2 AD2 5 ARG H 45 ILE H 51 -1 N GLY H 50 O ALA H 59 SHEET 3 AD2 5 TYR H 32 GLN H 39 -1 N ARG H 38 O GLU H 46 SHEET 4 AD2 5 VAL H 93 PRO H 100 -1 O ARG H 99 N ALA H 33 SHEET 5 AD2 5 SER H 112 TRP H 113 -1 O SER H 112 N ALA H 98 SHEET 1 AD3 5 THR H 58 TYR H 60 0 SHEET 2 AD3 5 ARG H 45 ILE H 51 -1 N GLY H 50 O ALA H 59 SHEET 3 AD3 5 TYR H 32 GLN H 39 -1 N ARG H 38 O GLU H 46 SHEET 4 AD3 5 VAL H 93 PRO H 100 -1 O ARG H 99 N ALA H 33 SHEET 5 AD3 5 THR H 117 GLN H 118 -1 O THR H 117 N TYR H 94 SHEET 1 AD4 4 GLN I 3 SER I 7 0 SHEET 2 AD4 4 LEU I 18 SER I 25 -1 O SER I 25 N GLN I 3 SHEET 3 AD4 4 THR I 78 MET I 83 -1 O MET I 83 N LEU I 18 SHEET 4 AD4 4 PHE I 68 ASP I 73 -1 N THR I 69 O GLN I 82 SHEET 1 AD5 2 VAL I 11 GLN I 13 0 SHEET 2 AD5 2 THR I 120 SER I 122 1 O SER I 122 N VAL I 12 SHEET 1 AD6 5 ALA I 59 TYR I 60 0 SHEET 2 AD6 5 ARG I 45 GLY I 50 -1 N GLY I 50 O ALA I 59 SHEET 3 AD6 5 TYR I 32 GLN I 39 -1 N ARG I 38 O GLU I 46 SHEET 4 AD6 5 VAL I 93 PRO I 100 -1 O ARG I 99 N ALA I 33 SHEET 5 AD6 5 SER I 112 TRP I 113 -1 O SER I 112 N ALA I 98 SHEET 1 AD7 5 ALA I 59 TYR I 60 0 SHEET 2 AD7 5 ARG I 45 GLY I 50 -1 N GLY I 50 O ALA I 59 SHEET 3 AD7 5 TYR I 32 GLN I 39 -1 N ARG I 38 O GLU I 46 SHEET 4 AD7 5 VAL I 93 PRO I 100 -1 O ARG I 99 N ALA I 33 SHEET 5 AD7 5 THR I 117 GLN I 118 -1 O THR I 117 N TYR I 94 SSBOND 1 CYS A 53 CYS A 609 1555 1555 2.03 SSBOND 2 CYS A 108 CYS A 135 1555 1555 2.03 SSBOND 3 CYS A 121 CYS A 147 1555 1555 2.03 SSBOND 4 CYS A 511 CYS A 556 1555 1555 2.04 SSBOND 5 CYS A 601 CYS A 608 1555 1555 2.04 SSBOND 6 CYS B 53 CYS B 609 1555 1555 2.03 SSBOND 7 CYS B 108 CYS B 135 1555 1555 2.03 SSBOND 8 CYS B 121 CYS B 147 1555 1555 2.03 SSBOND 9 CYS B 511 CYS B 556 1555 1555 2.04 SSBOND 10 CYS B 601 CYS B 608 1555 1555 2.04 SSBOND 11 CYS C 53 CYS C 609 1555 1555 2.02 SSBOND 12 CYS C 108 CYS C 135 1555 1555 2.03 SSBOND 13 CYS C 121 CYS C 147 1555 1555 2.03 SSBOND 14 CYS C 511 CYS C 556 1555 1555 2.04 SSBOND 15 CYS C 601 CYS C 608 1555 1555 2.03 SSBOND 16 CYS D 22 CYS D 96 1555 1555 2.04 SSBOND 17 CYS E 22 CYS E 96 1555 1555 2.03 SSBOND 18 CYS F 22 CYS F 96 1555 1555 2.04 SSBOND 19 CYS G 22 CYS G 96 1555 1555 2.03 SSBOND 20 CYS H 22 CYS H 96 1555 1555 2.03 SSBOND 21 CYS I 22 CYS I 96 1555 1555 2.03 LINK ND2 ASN A 257 C1 NAG A 701 1555 1555 1.45 LINK ND2 ASN A 563 C1 NAG J 1 1555 1555 1.45 LINK ND2 ASN B 257 C1 NAG B 701 1555 1555 1.46 LINK ND2 ASN B 563 C1 NAG L 1 1555 1555 1.46 LINK ND2 ASN C 257 C1 NAG C 701 1555 1555 1.46 LINK ND2 ASN C 563 C1 NAG K 1 1555 1555 1.46 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.44 LINK O4 NAG J 2 C1 BMA J 3 1555 1555 1.45 LINK O6 BMA J 3 C1 MAN J 4 1555 1555 1.45 LINK O3 BMA J 3 C1 MAN J 6 1555 1555 1.45 LINK O6 MAN J 4 C1 MAN J 5 1555 1555 1.45 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.44 LINK O6 BMA K 3 C1 MAN K 4 1555 1555 1.44 LINK O3 BMA K 3 C1 MAN K 6 1555 1555 1.44 LINK O6 MAN K 4 C1 MAN K 5 1555 1555 1.44 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.43 LINK O4 NAG L 2 C1 BMA L 3 1555 1555 1.44 LINK O3 BMA L 3 C1 MAN L 4 1555 1555 1.44 LINK O6 BMA L 3 C1 MAN L 5 1555 1555 1.43 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000