HEADER TRANSFERASE/IMMUNE SYSTEM 25-JUN-25 9PAV TITLE ANTIBODY (1B2) BOUND RIFAMYCIN SYNTHETASE MODULE 1 IN THE ELONGATION TITLE 2 MODE COMPND MOL_ID: 1; COMPND 2 MOLECULE: ANTIBODY FRAGMENT 1B2 HEAVY CHAIN; COMPND 3 CHAIN: H, G; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: ANTIBODY FRAGMENT 1B2 LIGHT CHAIN; COMPND 7 CHAIN: L, I; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 3; COMPND 10 MOLECULE: 6-DEOXYERYTHRONOLIDE-B SYNTHASE; COMPND 11 CHAIN: A, B; COMPND 12 EC: 2.3.1.94; COMPND 13 ENGINEERED: YES; COMPND 14 MOL_ID: 4; COMPND 15 MOLECULE: 6-DEOXYERYTHRONOLIDE-B SYNTHASE; COMPND 16 CHAIN: C; COMPND 17 EC: 2.3.1.94; COMPND 18 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_TAXID: 9606; SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 5 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_TAXID: 9606; SOURCE 9 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 10 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 11 MOL_ID: 3; SOURCE 12 ORGANISM_SCIENTIFIC: AMYCOLATOPSIS MEDITERRANEI; SOURCE 13 ORGANISM_TAXID: 33910; SOURCE 14 STRAIN: NRRL B-3240; SOURCE 15 ATCC: 13685; SOURCE 16 GENE: RIFA; SOURCE 17 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 18 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 19 EXPRESSION_SYSTEM_STRAIN: BAP1; SOURCE 20 EXPRESSION_SYSTEM_VECTOR_TYPE: PET21; SOURCE 21 EXPRESSION_SYSTEM_PLASMID: PDC43; SOURCE 22 MOL_ID: 4; SOURCE 23 ORGANISM_SCIENTIFIC: AMYCOLATOPSIS MEDITERRANEI; SOURCE 24 ORGANISM_TAXID: 33910; SOURCE 25 GENE: RIFA; SOURCE 26 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 27 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 28 EXPRESSION_SYSTEM_STRAIN: BAP1; SOURCE 29 EXPRESSION_SYSTEM_VECTOR_TYPE: PET21; SOURCE 30 EXPRESSION_SYSTEM_PLASMID: PDC43 KEYWDS POLYKETIDE SYNTHASE MODULE, ANTIBODY (FAB), TRANSFERASE-IMMUNE SYSTEM KEYWDS 2 COMPLEX EXPDTA ELECTRON MICROSCOPY AUTHOR D.P.COGAN,C.LIU,R.C.WEST,M.CHEN REVDAT 1 23-JUL-25 9PAV 0 JRNL AUTH C.LIU,R.C.WEST,M.CHEN,W.COHN,G.WANG,A.M.MANDOT,S.KIM, JRNL AUTH 2 D.P.COGAN JRNL TITL MOLECULAR BASIS FOR ASYNCHRONOUS CHAIN ELONGATION DURING JRNL TITL 2 RIFAMYCIN ANTIBIOTIC BIOSYNTHESIS. JRNL REF BIORXIV 2025 JRNL REFN ISSN 2692-8205 JRNL PMID 40631255 JRNL DOI 10.1101/2025.07.05.663307 REMARK 2 REMARK 2 RESOLUTION. 3.22 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, CRYOSPARC, UCSF CHIMERAX, REMARK 3 CRYOSPARC, CRYOSPARC, RELION, CRYOSPARC, REMARK 3 PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.220 REMARK 3 NUMBER OF PARTICLES : 177509 REMARK 3 CTF CORRECTION METHOD : NONE REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9PAV COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 30-JUN-25. REMARK 100 THE DEPOSITION ID IS D_1000296166. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : TWO ANTIBODY FRAGMENTS (FABS) REMARK 245 IN COMPLEX WITH HOMODIMERIC REMARK 245 POLYKETIDE SYNTHASE MODULE 1 OF REMARK 245 THE RIFAMYCIN SYNTHETASE REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 10.00 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.20 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 10005 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1188.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3988.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEPTAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEPTAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, G, I, A, B, C REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET H 1 REMARK 465 ALA H 2 REMARK 465 LYS H 136 REMARK 465 SER H 137 REMARK 465 THR H 138 REMARK 465 SER H 139 REMARK 465 GLY H 140 REMARK 465 GLY H 141 REMARK 465 THR H 142 REMARK 465 SER H 194 REMARK 465 SER H 195 REMARK 465 LEU H 196 REMARK 465 GLY H 197 REMARK 465 THR H 198 REMARK 465 GLN H 199 REMARK 465 LYS H 221 REMARK 465 SER H 222 REMARK 465 CYS H 223 REMARK 465 ALA H 224 REMARK 465 ALA H 225 REMARK 465 LEU H 226 REMARK 465 VAL H 227 REMARK 465 PRO H 228 REMARK 465 ARG H 229 REMARK 465 GLY H 230 REMARK 465 SER H 231 REMARK 465 ALA H 232 REMARK 465 HIS H 233 REMARK 465 HIS H 234 REMARK 465 HIS H 235 REMARK 465 HIS H 236 REMARK 465 HIS H 237 REMARK 465 HIS H 238 REMARK 465 ALA H 239 REMARK 465 ALA H 240 REMARK 465 ASP H 241 REMARK 465 TYR H 242 REMARK 465 LYS H 243 REMARK 465 ASP H 244 REMARK 465 ASP H 245 REMARK 465 ASP H 246 REMARK 465 ASP H 247 REMARK 465 LYS H 248 REMARK 465 ALA H 249 REMARK 465 LEU L 1 REMARK 465 PHE L 2 REMARK 465 ALA L 3 REMARK 465 ILE L 4 REMARK 465 PRO L 5 REMARK 465 LEU L 6 REMARK 465 VAL L 7 REMARK 465 VAL L 8 REMARK 465 PRO L 9 REMARK 465 PHE L 10 REMARK 465 TYR L 11 REMARK 465 SER L 12 REMARK 465 HIS L 13 REMARK 465 SER L 14 REMARK 465 ALA L 15 REMARK 465 LEU L 16 REMARK 465 ASP L 173 REMARK 465 ASN L 174 REMARK 465 ALA L 175 REMARK 465 LEU L 176 REMARK 465 VAL L 213 REMARK 465 TYR L 214 REMARK 465 ASN L 232 REMARK 465 ARG L 233 REMARK 465 GLY L 234 REMARK 465 GLU L 235 REMARK 465 CYS L 236 REMARK 465 MET G 1 REMARK 465 ALA G 2 REMARK 465 LYS G 136 REMARK 465 SER G 137 REMARK 465 THR G 138 REMARK 465 SER G 139 REMARK 465 GLY G 140 REMARK 465 GLY G 141 REMARK 465 THR G 142 REMARK 465 SER G 194 REMARK 465 SER G 195 REMARK 465 LEU G 196 REMARK 465 GLY G 197 REMARK 465 THR G 198 REMARK 465 GLN G 199 REMARK 465 LYS G 221 REMARK 465 SER G 222 REMARK 465 CYS G 223 REMARK 465 ALA G 224 REMARK 465 ALA G 225 REMARK 465 LEU G 226 REMARK 465 VAL G 227 REMARK 465 PRO G 228 REMARK 465 ARG G 229 REMARK 465 GLY G 230 REMARK 465 SER G 231 REMARK 465 ALA G 232 REMARK 465 HIS G 233 REMARK 465 HIS G 234 REMARK 465 HIS G 235 REMARK 465 HIS G 236 REMARK 465 HIS G 237 REMARK 465 HIS G 238 REMARK 465 ALA G 239 REMARK 465 ALA G 240 REMARK 465 ASP G 241 REMARK 465 TYR G 242 REMARK 465 LYS G 243 REMARK 465 ASP G 244 REMARK 465 ASP G 245 REMARK 465 ASP G 246 REMARK 465 ASP G 247 REMARK 465 LYS G 248 REMARK 465 ALA G 249 REMARK 465 LEU I 1 REMARK 465 PHE I 2 REMARK 465 ALA I 3 REMARK 465 ILE I 4 REMARK 465 PRO I 5 REMARK 465 LEU I 6 REMARK 465 VAL I 7 REMARK 465 VAL I 8 REMARK 465 PRO I 9 REMARK 465 PHE I 10 REMARK 465 TYR I 11 REMARK 465 SER I 12 REMARK 465 HIS I 13 REMARK 465 SER I 14 REMARK 465 ALA I 15 REMARK 465 LEU I 16 REMARK 465 ASP I 173 REMARK 465 ASN I 174 REMARK 465 ALA I 175 REMARK 465 LEU I 176 REMARK 465 VAL I 213 REMARK 465 TYR I 214 REMARK 465 ASN I 232 REMARK 465 ARG I 233 REMARK 465 GLY I 234 REMARK 465 GLU I 235 REMARK 465 CYS I 236 REMARK 465 GLU A 884 REMARK 465 PRO A 885 REMARK 465 ALA A 886 REMARK 465 SER A 887 REMARK 465 ALA A 888 REMARK 465 GLY A 889 REMARK 465 PRO A 1479 REMARK 465 ARG A 1480 REMARK 465 ARG A 1481 REMARK 465 ALA A 1482 REMARK 465 ALA A 1483 REMARK 465 ALA A 1484 REMARK 465 LYS A 1485 REMARK 465 THR A 1486 REMARK 465 ALA A 1487 REMARK 465 SER A 1488 REMARK 465 LEU A 1489 REMARK 465 THR A 1490 REMARK 465 GLU A 1491 REMARK 465 ARG A 1492 REMARK 465 LEU A 1493 REMARK 465 ALA A 1494 REMARK 465 GLY A 1495 REMARK 465 LEU A 1496 REMARK 465 ALA A 1497 REMARK 465 GLU A 1498 REMARK 465 THR A 1499 REMARK 465 GLU A 1500 REMARK 465 GLN A 1501 REMARK 465 ALA A 1502 REMARK 465 ALA A 1503 REMARK 465 ALA A 1504 REMARK 465 LEU A 1505 REMARK 465 LEU A 1506 REMARK 465 ASP A 1507 REMARK 465 LEU A 1508 REMARK 465 VAL A 1509 REMARK 465 ARG A 1510 REMARK 465 ARG A 1511 REMARK 465 HIS A 1512 REMARK 465 ALA A 1513 REMARK 465 ALA A 1514 REMARK 465 GLU A 1515 REMARK 465 VAL A 1516 REMARK 465 LEU A 1517 REMARK 465 GLY A 1518 REMARK 465 HIS A 1519 REMARK 465 SER A 1520 REMARK 465 GLY A 1521 REMARK 465 ALA A 1522 REMARK 465 GLU A 1523 REMARK 465 SER A 1524 REMARK 465 VAL A 1525 REMARK 465 HIS A 1526 REMARK 465 SER A 1527 REMARK 465 GLY A 1528 REMARK 465 ARG A 1529 REMARK 465 THR A 1530 REMARK 465 PHE A 1531 REMARK 465 LYS A 1532 REMARK 465 ASP A 1533 REMARK 465 ALA A 1534 REMARK 465 GLY A 1535 REMARK 465 PHE A 1536 REMARK 465 ASP A 1537 REMARK 465 SER A 1538 REMARK 465 LEU A 1539 REMARK 465 THR A 1540 REMARK 465 ALA A 1541 REMARK 465 VAL A 1542 REMARK 465 GLU A 1543 REMARK 465 LEU A 1544 REMARK 465 ARG A 1545 REMARK 465 ASN A 1546 REMARK 465 ARG A 1547 REMARK 465 LEU A 1548 REMARK 465 ALA A 1549 REMARK 465 ALA A 1550 REMARK 465 ALA A 1551 REMARK 465 THR A 1552 REMARK 465 GLY A 1553 REMARK 465 LEU A 1554 REMARK 465 THR A 1555 REMARK 465 LEU A 1556 REMARK 465 SER A 1557 REMARK 465 PRO A 1558 REMARK 465 ALA A 1559 REMARK 465 MET A 1560 REMARK 465 ILE A 1561 REMARK 465 PHE A 1562 REMARK 465 ASP A 1563 REMARK 465 TYR A 1564 REMARK 465 PRO A 1565 REMARK 465 LYS A 1566 REMARK 465 PRO A 1567 REMARK 465 PRO A 1568 REMARK 465 ALA A 1569 REMARK 465 LEU A 1570 REMARK 465 ALA A 1571 REMARK 465 ASP A 1572 REMARK 465 HIS A 1573 REMARK 465 LEU A 1574 REMARK 465 ARG A 1575 REMARK 465 ALA A 1576 REMARK 465 LYS A 1577 REMARK 465 LEU A 1578 REMARK 465 PHE A 1579 REMARK 465 GLY A 1580 REMARK 465 THR A 1581 REMARK 465 GLU A 1582 REMARK 465 VAL A 1583 REMARK 465 ARG A 1584 REMARK 465 GLY A 1585 REMARK 465 GLU A 1586 REMARK 465 ALA A 1587 REMARK 465 PRO A 1588 REMARK 465 SER A 1589 REMARK 465 ALA A 1590 REMARK 465 LEU A 1591 REMARK 465 ALA A 1592 REMARK 465 GLY A 1593 REMARK 465 LEU A 1594 REMARK 465 ASP A 1595 REMARK 465 ALA A 1596 REMARK 465 LEU A 1597 REMARK 465 GLU A 1598 REMARK 465 ALA A 1599 REMARK 465 ALA A 1600 REMARK 465 LEU A 1601 REMARK 465 PRO A 1602 REMARK 465 GLU A 1603 REMARK 465 VAL A 1604 REMARK 465 PRO A 1605 REMARK 465 ALA A 1606 REMARK 465 THR A 1607 REMARK 465 GLU A 1608 REMARK 465 ARG A 1609 REMARK 465 GLU A 1610 REMARK 465 GLU A 1611 REMARK 465 LEU A 1612 REMARK 465 VAL A 1613 REMARK 465 GLN A 1614 REMARK 465 ARG A 1615 REMARK 465 LEU A 1616 REMARK 465 GLU A 1617 REMARK 465 ARG A 1618 REMARK 465 MET A 1619 REMARK 465 LEU A 1620 REMARK 465 ALA A 1621 REMARK 465 ALA A 1622 REMARK 465 LEU A 1623 REMARK 465 ARG A 1624 REMARK 465 PRO A 1625 REMARK 465 VAL A 1626 REMARK 465 ALA A 1627 REMARK 465 GLN A 1628 REMARK 465 ALA A 1629 REMARK 465 ALA A 1630 REMARK 465 ASP A 1631 REMARK 465 ALA A 1632 REMARK 465 SER A 1633 REMARK 465 GLY A 1634 REMARK 465 THR A 1635 REMARK 465 GLY A 1636 REMARK 465 ALA A 1637 REMARK 465 ASN A 1638 REMARK 465 PRO A 1639 REMARK 465 SER A 1640 REMARK 465 GLY A 1641 REMARK 465 ASP A 1642 REMARK 465 ASP A 1643 REMARK 465 LEU A 1644 REMARK 465 GLY A 1645 REMARK 465 GLU A 1646 REMARK 465 ALA A 1647 REMARK 465 GLY A 1648 REMARK 465 VAL A 1649 REMARK 465 ASP A 1650 REMARK 465 GLU A 1651 REMARK 465 LEU A 1652 REMARK 465 LEU A 1653 REMARK 465 GLU A 1654 REMARK 465 ALA A 1655 REMARK 465 LEU A 1656 REMARK 465 GLY A 1657 REMARK 465 ARG A 1658 REMARK 465 GLU A 1659 REMARK 465 LEU A 1660 REMARK 465 ASP A 1661 REMARK 465 GLY A 1662 REMARK 465 ASP A 1663 REMARK 465 GLY A 1664 REMARK 465 ASN A 1665 REMARK 465 SER A 1666 REMARK 465 SER A 1667 REMARK 465 SER A 1668 REMARK 465 VAL A 1669 REMARK 465 ASP A 1670 REMARK 465 LYS A 1671 REMARK 465 LEU A 1672 REMARK 465 ALA A 1673 REMARK 465 ALA A 1674 REMARK 465 ALA A 1675 REMARK 465 LEU A 1676 REMARK 465 GLU A 1677 REMARK 465 HIS A 1678 REMARK 465 HIS A 1679 REMARK 465 HIS A 1680 REMARK 465 HIS A 1681 REMARK 465 HIS A 1682 REMARK 465 HIS A 1683 REMARK 465 GLU B 884 REMARK 465 PRO B 885 REMARK 465 ALA B 886 REMARK 465 SER B 887 REMARK 465 ALA B 888 REMARK 465 GLY B 889 REMARK 465 ALA B 1097 REMARK 465 GLU B 1098 REMARK 465 GLN B 1099 REMARK 465 GLY B 1100 REMARK 465 THR B 1101 REMARK 465 THR B 1102 REMARK 465 ASP B 1103 REMARK 465 ALA B 1104 REMARK 465 LEU B 1105 REMARK 465 PHE B 1106 REMARK 465 ARG B 1107 REMARK 465 VAL B 1108 REMARK 465 ASP B 1109 REMARK 465 TRP B 1110 REMARK 465 PRO B 1111 REMARK 465 GLU B 1112 REMARK 465 ILE B 1113 REMARK 465 PRO B 1114 REMARK 465 LEU B 1115 REMARK 465 PRO B 1116 REMARK 465 THR B 1117 REMARK 465 ALA B 1118 REMARK 465 GLU B 1119 REMARK 465 THR B 1120 REMARK 465 ALA B 1121 REMARK 465 ASP B 1122 REMARK 465 PHE B 1123 REMARK 465 LEU B 1124 REMARK 465 PRO B 1125 REMARK 465 TYR B 1126 REMARK 465 GLU B 1127 REMARK 465 ALA B 1128 REMARK 465 THR B 1129 REMARK 465 SER B 1130 REMARK 465 ALA B 1131 REMARK 465 GLU B 1132 REMARK 465 ALA B 1133 REMARK 465 THR B 1134 REMARK 465 LEU B 1135 REMARK 465 SER B 1136 REMARK 465 ALA B 1137 REMARK 465 LEU B 1138 REMARK 465 GLN B 1139 REMARK 465 ALA B 1140 REMARK 465 TRP B 1141 REMARK 465 LEU B 1142 REMARK 465 ALA B 1143 REMARK 465 ASP B 1144 REMARK 465 PRO B 1145 REMARK 465 ALA B 1146 REMARK 465 GLU B 1147 REMARK 465 THR B 1148 REMARK 465 ARG B 1149 REMARK 465 LEU B 1150 REMARK 465 ALA B 1151 REMARK 465 VAL B 1152 REMARK 465 VAL B 1153 REMARK 465 THR B 1154 REMARK 465 GLY B 1155 REMARK 465 ASP B 1156 REMARK 465 CYS B 1157 REMARK 465 THR B 1158 REMARK 465 GLU B 1159 REMARK 465 PRO B 1160 REMARK 465 GLY B 1161 REMARK 465 ALA B 1162 REMARK 465 ALA B 1163 REMARK 465 ALA B 1164 REMARK 465 ILE B 1165 REMARK 465 TRP B 1166 REMARK 465 GLY B 1167 REMARK 465 LEU B 1168 REMARK 465 VAL B 1169 REMARK 465 ARG B 1170 REMARK 465 SER B 1171 REMARK 465 ALA B 1172 REMARK 465 GLN B 1173 REMARK 465 SER B 1174 REMARK 465 GLU B 1175 REMARK 465 HIS B 1176 REMARK 465 PRO B 1177 REMARK 465 GLY B 1178 REMARK 465 ARG B 1179 REMARK 465 ILE B 1180 REMARK 465 VAL B 1181 REMARK 465 LEU B 1182 REMARK 465 ALA B 1183 REMARK 465 ASP B 1184 REMARK 465 LEU B 1185 REMARK 465 ASP B 1186 REMARK 465 ASP B 1187 REMARK 465 PRO B 1188 REMARK 465 ALA B 1189 REMARK 465 VAL B 1190 REMARK 465 LEU B 1191 REMARK 465 PRO B 1192 REMARK 465 ALA B 1193 REMARK 465 VAL B 1194 REMARK 465 VAL B 1195 REMARK 465 ALA B 1196 REMARK 465 SER B 1197 REMARK 465 GLY B 1198 REMARK 465 GLU B 1199 REMARK 465 PRO B 1200 REMARK 465 GLN B 1201 REMARK 465 VAL B 1202 REMARK 465 ARG B 1203 REMARK 465 VAL B 1204 REMARK 465 ARG B 1205 REMARK 465 ASN B 1206 REMARK 465 GLY B 1207 REMARK 465 VAL B 1208 REMARK 465 ALA B 1209 REMARK 465 SER B 1210 REMARK 465 VAL B 1211 REMARK 465 PRO B 1212 REMARK 465 ARG B 1213 REMARK 465 LEU B 1214 REMARK 465 THR B 1215 REMARK 465 ARG B 1216 REMARK 465 VAL B 1217 REMARK 465 THR B 1218 REMARK 465 PRO B 1219 REMARK 465 ARG B 1220 REMARK 465 GLN B 1221 REMARK 465 ASP B 1222 REMARK 465 ALA B 1223 REMARK 465 ARG B 1224 REMARK 465 PRO B 1225 REMARK 465 LEU B 1226 REMARK 465 ASP B 1227 REMARK 465 PRO B 1228 REMARK 465 GLU B 1229 REMARK 465 GLY B 1230 REMARK 465 THR B 1231 REMARK 465 VAL B 1232 REMARK 465 LEU B 1233 REMARK 465 ILE B 1234 REMARK 465 THR B 1235 REMARK 465 GLY B 1236 REMARK 465 GLY B 1237 REMARK 465 THR B 1238 REMARK 465 GLY B 1239 REMARK 465 THR B 1240 REMARK 465 LEU B 1241 REMARK 465 GLY B 1242 REMARK 465 ALA B 1243 REMARK 465 LEU B 1244 REMARK 465 THR B 1245 REMARK 465 ALA B 1246 REMARK 465 ARG B 1247 REMARK 465 HIS B 1248 REMARK 465 LEU B 1249 REMARK 465 VAL B 1250 REMARK 465 THR B 1251 REMARK 465 ALA B 1252 REMARK 465 HIS B 1253 REMARK 465 GLY B 1254 REMARK 465 VAL B 1255 REMARK 465 ARG B 1256 REMARK 465 HIS B 1257 REMARK 465 LEU B 1258 REMARK 465 VAL B 1259 REMARK 465 LEU B 1260 REMARK 465 VAL B 1261 REMARK 465 SER B 1262 REMARK 465 ARG B 1263 REMARK 465 ARG B 1264 REMARK 465 GLY B 1265 REMARK 465 GLU B 1266 REMARK 465 ALA B 1267 REMARK 465 PRO B 1268 REMARK 465 GLU B 1269 REMARK 465 LEU B 1270 REMARK 465 GLN B 1271 REMARK 465 GLU B 1272 REMARK 465 GLU B 1273 REMARK 465 LEU B 1274 REMARK 465 THR B 1275 REMARK 465 ALA B 1276 REMARK 465 LEU B 1277 REMARK 465 GLY B 1278 REMARK 465 ALA B 1279 REMARK 465 SER B 1280 REMARK 465 VAL B 1281 REMARK 465 ALA B 1282 REMARK 465 ILE B 1283 REMARK 465 ALA B 1284 REMARK 465 ALA B 1285 REMARK 465 CYS B 1286 REMARK 465 ASP B 1287 REMARK 465 VAL B 1288 REMARK 465 ALA B 1289 REMARK 465 ASP B 1290 REMARK 465 ARG B 1291 REMARK 465 ALA B 1292 REMARK 465 GLN B 1293 REMARK 465 LEU B 1294 REMARK 465 GLU B 1295 REMARK 465 ALA B 1296 REMARK 465 VAL B 1297 REMARK 465 LEU B 1298 REMARK 465 ARG B 1299 REMARK 465 ALA B 1300 REMARK 465 ILE B 1301 REMARK 465 PRO B 1302 REMARK 465 ALA B 1303 REMARK 465 GLU B 1304 REMARK 465 HIS B 1305 REMARK 465 PRO B 1306 REMARK 465 LEU B 1307 REMARK 465 THR B 1308 REMARK 465 ALA B 1309 REMARK 465 VAL B 1310 REMARK 465 ILE B 1311 REMARK 465 HIS B 1312 REMARK 465 THR B 1313 REMARK 465 ALA B 1314 REMARK 465 GLY B 1315 REMARK 465 VAL B 1316 REMARK 465 LEU B 1317 REMARK 465 ASP B 1318 REMARK 465 ASP B 1319 REMARK 465 GLY B 1320 REMARK 465 VAL B 1321 REMARK 465 VAL B 1322 REMARK 465 THR B 1323 REMARK 465 GLU B 1324 REMARK 465 LEU B 1325 REMARK 465 THR B 1326 REMARK 465 PRO B 1327 REMARK 465 ASP B 1328 REMARK 465 ARG B 1329 REMARK 465 LEU B 1330 REMARK 465 ALA B 1331 REMARK 465 THR B 1332 REMARK 465 VAL B 1333 REMARK 465 ARG B 1334 REMARK 465 ARG B 1335 REMARK 465 PRO B 1336 REMARK 465 LYS B 1337 REMARK 465 VAL B 1338 REMARK 465 ASP B 1339 REMARK 465 ALA B 1340 REMARK 465 ALA B 1341 REMARK 465 ARG B 1342 REMARK 465 LEU B 1343 REMARK 465 LEU B 1344 REMARK 465 ASP B 1345 REMARK 465 GLU B 1346 REMARK 465 LEU B 1347 REMARK 465 THR B 1348 REMARK 465 ARG B 1349 REMARK 465 GLU B 1350 REMARK 465 ALA B 1351 REMARK 465 ASP B 1352 REMARK 465 LEU B 1353 REMARK 465 ALA B 1354 REMARK 465 ALA B 1355 REMARK 465 PHE B 1356 REMARK 465 VAL B 1357 REMARK 465 LEU B 1358 REMARK 465 PHE B 1359 REMARK 465 SER B 1360 REMARK 465 SER B 1361 REMARK 465 ALA B 1362 REMARK 465 ALA B 1363 REMARK 465 GLY B 1364 REMARK 465 VAL B 1365 REMARK 465 LEU B 1366 REMARK 465 GLY B 1367 REMARK 465 ASN B 1368 REMARK 465 PRO B 1369 REMARK 465 GLY B 1370 REMARK 465 GLN B 1371 REMARK 465 ALA B 1372 REMARK 465 GLY B 1373 REMARK 465 TYR B 1374 REMARK 465 ALA B 1375 REMARK 465 ALA B 1376 REMARK 465 ALA B 1377 REMARK 465 ASN B 1378 REMARK 465 ALA B 1379 REMARK 465 GLU B 1380 REMARK 465 LEU B 1381 REMARK 465 ASP B 1382 REMARK 465 ALA B 1383 REMARK 465 LEU B 1384 REMARK 465 ALA B 1385 REMARK 465 ARG B 1386 REMARK 465 GLN B 1387 REMARK 465 ARG B 1388 REMARK 465 ASN B 1389 REMARK 465 SER B 1390 REMARK 465 LEU B 1391 REMARK 465 ASP B 1392 REMARK 465 LEU B 1393 REMARK 465 PRO B 1394 REMARK 465 ALA B 1395 REMARK 465 VAL B 1396 REMARK 465 SER B 1397 REMARK 465 ILE B 1398 REMARK 465 ALA B 1399 REMARK 465 TRP B 1400 REMARK 465 GLY B 1401 REMARK 465 TYR B 1402 REMARK 465 TRP B 1403 REMARK 465 ALA B 1404 REMARK 465 THR B 1405 REMARK 465 VAL B 1406 REMARK 465 SER B 1407 REMARK 465 GLY B 1408 REMARK 465 MET B 1409 REMARK 465 THR B 1410 REMARK 465 GLU B 1411 REMARK 465 HIS B 1412 REMARK 465 LEU B 1413 REMARK 465 GLY B 1414 REMARK 465 ASP B 1415 REMARK 465 ALA B 1416 REMARK 465 ASP B 1417 REMARK 465 LEU B 1418 REMARK 465 ARG B 1419 REMARK 465 ARG B 1420 REMARK 465 ASN B 1421 REMARK 465 GLN B 1422 REMARK 465 ARG B 1423 REMARK 465 ILE B 1424 REMARK 465 GLY B 1425 REMARK 465 MET B 1426 REMARK 465 SER B 1427 REMARK 465 GLY B 1428 REMARK 465 LEU B 1429 REMARK 465 PRO B 1430 REMARK 465 ALA B 1431 REMARK 465 ASP B 1432 REMARK 465 GLU B 1433 REMARK 465 GLY B 1434 REMARK 465 MET B 1435 REMARK 465 ALA B 1436 REMARK 465 LEU B 1437 REMARK 465 LEU B 1438 REMARK 465 ASP B 1439 REMARK 465 ALA B 1440 REMARK 465 ALA B 1441 REMARK 465 ILE B 1442 REMARK 465 ALA B 1443 REMARK 465 THR B 1444 REMARK 465 GLY B 1445 REMARK 465 GLY B 1446 REMARK 465 THR B 1447 REMARK 465 LEU B 1448 REMARK 465 VAL B 1449 REMARK 465 ALA B 1450 REMARK 465 ALA B 1451 REMARK 465 LYS B 1452 REMARK 465 PHE B 1453 REMARK 465 ASP B 1454 REMARK 465 VAL B 1455 REMARK 465 ALA B 1456 REMARK 465 ALA B 1457 REMARK 465 LEU B 1458 REMARK 465 ARG B 1459 REMARK 465 ALA B 1460 REMARK 465 THR B 1461 REMARK 465 ALA B 1462 REMARK 465 LYS B 1463 REMARK 465 ALA B 1464 REMARK 465 GLY B 1465 REMARK 465 GLY B 1466 REMARK 465 PRO B 1467 REMARK 465 VAL B 1468 REMARK 465 PRO B 1469 REMARK 465 PRO B 1470 REMARK 465 LEU B 1471 REMARK 465 LEU B 1472 REMARK 465 ARG B 1473 REMARK 465 GLY B 1474 REMARK 465 LEU B 1475 REMARK 465 ALA B 1476 REMARK 465 PRO B 1477 REMARK 465 LEU B 1478 REMARK 465 PRO B 1479 REMARK 465 ARG B 1480 REMARK 465 ARG B 1481 REMARK 465 ALA B 1482 REMARK 465 ALA B 1483 REMARK 465 ALA B 1484 REMARK 465 LYS B 1485 REMARK 465 THR B 1486 REMARK 465 ALA B 1487 REMARK 465 SER B 1488 REMARK 465 LEU B 1489 REMARK 465 THR B 1490 REMARK 465 GLU B 1491 REMARK 465 ARG B 1492 REMARK 465 LEU B 1493 REMARK 465 ALA B 1494 REMARK 465 GLY B 1495 REMARK 465 LEU B 1496 REMARK 465 ALA B 1497 REMARK 465 GLU B 1498 REMARK 465 THR B 1499 REMARK 465 GLU B 1500 REMARK 465 GLN B 1501 REMARK 465 ALA B 1502 REMARK 465 ALA B 1503 REMARK 465 ALA B 1504 REMARK 465 LEU B 1505 REMARK 465 LEU B 1506 REMARK 465 ASP B 1507 REMARK 465 LEU B 1508 REMARK 465 VAL B 1509 REMARK 465 ARG B 1510 REMARK 465 ARG B 1511 REMARK 465 HIS B 1512 REMARK 465 ALA B 1513 REMARK 465 ALA B 1514 REMARK 465 GLU B 1515 REMARK 465 VAL B 1516 REMARK 465 LEU B 1517 REMARK 465 GLY B 1518 REMARK 465 HIS B 1519 REMARK 465 SER B 1520 REMARK 465 GLY B 1521 REMARK 465 ALA B 1522 REMARK 465 GLU B 1523 REMARK 465 SER B 1524 REMARK 465 VAL B 1525 REMARK 465 HIS B 1526 REMARK 465 SER B 1527 REMARK 465 GLY B 1528 REMARK 465 ARG B 1529 REMARK 465 THR B 1530 REMARK 465 PHE B 1531 REMARK 465 LYS B 1532 REMARK 465 ASP B 1533 REMARK 465 ALA B 1534 REMARK 465 GLY B 1535 REMARK 465 PHE B 1536 REMARK 465 ASP B 1537 REMARK 465 SER B 1538 REMARK 465 LEU B 1539 REMARK 465 THR B 1540 REMARK 465 ALA B 1541 REMARK 465 VAL B 1542 REMARK 465 GLU B 1543 REMARK 465 LEU B 1544 REMARK 465 ARG B 1545 REMARK 465 ASN B 1546 REMARK 465 ARG B 1547 REMARK 465 LEU B 1548 REMARK 465 ALA B 1549 REMARK 465 ALA B 1550 REMARK 465 ALA B 1551 REMARK 465 THR B 1552 REMARK 465 GLY B 1553 REMARK 465 LEU B 1554 REMARK 465 THR B 1555 REMARK 465 LEU B 1556 REMARK 465 SER B 1557 REMARK 465 PRO B 1558 REMARK 465 ALA B 1559 REMARK 465 MET B 1560 REMARK 465 ILE B 1561 REMARK 465 PHE B 1562 REMARK 465 ASP B 1563 REMARK 465 TYR B 1564 REMARK 465 PRO B 1565 REMARK 465 LYS B 1566 REMARK 465 PRO B 1567 REMARK 465 PRO B 1568 REMARK 465 ALA B 1569 REMARK 465 LEU B 1570 REMARK 465 ALA B 1571 REMARK 465 ASP B 1572 REMARK 465 HIS B 1573 REMARK 465 LEU B 1574 REMARK 465 ARG B 1575 REMARK 465 ALA B 1576 REMARK 465 LYS B 1577 REMARK 465 LEU B 1578 REMARK 465 PHE B 1579 REMARK 465 GLY B 1580 REMARK 465 THR B 1581 REMARK 465 GLU B 1582 REMARK 465 VAL B 1583 REMARK 465 ARG B 1584 REMARK 465 GLY B 1585 REMARK 465 GLU B 1586 REMARK 465 ALA B 1587 REMARK 465 PRO B 1588 REMARK 465 SER B 1589 REMARK 465 ALA B 1590 REMARK 465 LEU B 1591 REMARK 465 ALA B 1592 REMARK 465 GLY B 1593 REMARK 465 LEU B 1594 REMARK 465 ASP B 1595 REMARK 465 ALA B 1596 REMARK 465 LEU B 1597 REMARK 465 GLU B 1598 REMARK 465 ALA B 1599 REMARK 465 ALA B 1600 REMARK 465 LEU B 1601 REMARK 465 PRO B 1602 REMARK 465 GLU B 1603 REMARK 465 VAL B 1604 REMARK 465 PRO B 1605 REMARK 465 ALA B 1606 REMARK 465 THR B 1607 REMARK 465 GLU B 1608 REMARK 465 ARG B 1609 REMARK 465 GLU B 1610 REMARK 465 GLU B 1611 REMARK 465 LEU B 1612 REMARK 465 VAL B 1613 REMARK 465 GLN B 1614 REMARK 465 ARG B 1615 REMARK 465 LEU B 1616 REMARK 465 GLU B 1617 REMARK 465 ARG B 1618 REMARK 465 MET B 1619 REMARK 465 LEU B 1620 REMARK 465 ALA B 1621 REMARK 465 ALA B 1622 REMARK 465 LEU B 1623 REMARK 465 ARG B 1624 REMARK 465 PRO B 1625 REMARK 465 VAL B 1626 REMARK 465 ALA B 1627 REMARK 465 GLN B 1628 REMARK 465 ALA B 1629 REMARK 465 ALA B 1630 REMARK 465 ASP B 1631 REMARK 465 ALA B 1632 REMARK 465 SER B 1633 REMARK 465 GLY B 1634 REMARK 465 THR B 1635 REMARK 465 GLY B 1636 REMARK 465 ALA B 1637 REMARK 465 ASN B 1638 REMARK 465 PRO B 1639 REMARK 465 SER B 1640 REMARK 465 GLY B 1641 REMARK 465 ASP B 1642 REMARK 465 ASP B 1643 REMARK 465 LEU B 1644 REMARK 465 GLY B 1645 REMARK 465 GLU B 1646 REMARK 465 ALA B 1647 REMARK 465 GLY B 1648 REMARK 465 VAL B 1649 REMARK 465 ASP B 1650 REMARK 465 GLU B 1651 REMARK 465 LEU B 1652 REMARK 465 LEU B 1653 REMARK 465 GLU B 1654 REMARK 465 ALA B 1655 REMARK 465 LEU B 1656 REMARK 465 GLY B 1657 REMARK 465 ARG B 1658 REMARK 465 GLU B 1659 REMARK 465 LEU B 1660 REMARK 465 ASP B 1661 REMARK 465 GLY B 1662 REMARK 465 ASP B 1663 REMARK 465 GLY B 1664 REMARK 465 ASN B 1665 REMARK 465 SER B 1666 REMARK 465 SER B 1667 REMARK 465 SER B 1668 REMARK 465 VAL B 1669 REMARK 465 ASP B 1670 REMARK 465 LYS B 1671 REMARK 465 LEU B 1672 REMARK 465 ALA B 1673 REMARK 465 ALA B 1674 REMARK 465 ALA B 1675 REMARK 465 LEU B 1676 REMARK 465 GLU B 1677 REMARK 465 HIS B 1678 REMARK 465 HIS B 1679 REMARK 465 HIS B 1680 REMARK 465 HIS B 1681 REMARK 465 HIS B 1682 REMARK 465 HIS B 1683 REMARK 465 MET C 1 REMARK 465 ALA C 2 REMARK 465 SER C 3 REMARK 465 THR C 4 REMARK 465 ASP C 5 REMARK 465 SER C 6 REMARK 465 GLU C 7 REMARK 465 LYS C 8 REMARK 465 VAL C 9 REMARK 465 ALA C 10 REMARK 465 GLU C 11 REMARK 465 TYR C 12 REMARK 465 LEU C 13 REMARK 465 ARG C 14 REMARK 465 ARG C 15 REMARK 465 ALA C 16 REMARK 465 THR C 17 REMARK 465 LEU C 18 REMARK 465 ASP C 19 REMARK 465 LEU C 20 REMARK 465 ARG C 21 REMARK 465 ALA C 22 REMARK 465 ALA C 23 REMARK 465 ARG C 24 REMARK 465 GLN C 25 REMARK 465 ARG C 26 REMARK 465 ILE C 27 REMARK 465 ARG C 28 REMARK 465 GLU C 29 REMARK 465 LEU C 30 REMARK 465 GLU C 31 REMARK 465 GLY C 32 REMARK 465 GLU C 33 REMARK 465 PRO C 34 REMARK 465 ILE C 35 REMARK 465 ALA C 36 REMARK 465 ILE C 37 REMARK 465 VAL C 38 REMARK 465 GLY C 39 REMARK 465 MET C 40 REMARK 465 ALA C 41 REMARK 465 CYS C 42 REMARK 465 ARG C 43 REMARK 465 LEU C 44 REMARK 465 PRO C 45 REMARK 465 GLY C 46 REMARK 465 GLY C 47 REMARK 465 VAL C 48 REMARK 465 ALA C 49 REMARK 465 SER C 50 REMARK 465 PRO C 51 REMARK 465 GLU C 52 REMARK 465 ASP C 53 REMARK 465 LEU C 54 REMARK 465 TRP C 55 REMARK 465 ARG C 56 REMARK 465 LEU C 57 REMARK 465 VAL C 58 REMARK 465 ALA C 59 REMARK 465 GLU C 60 REMARK 465 ARG C 61 REMARK 465 VAL C 62 REMARK 465 ASP C 63 REMARK 465 ALA C 64 REMARK 465 VAL C 65 REMARK 465 SER C 66 REMARK 465 GLU C 67 REMARK 465 PHE C 68 REMARK 465 PRO C 69 REMARK 465 GLY C 70 REMARK 465 ASP C 71 REMARK 465 ARG C 72 REMARK 465 GLY C 73 REMARK 465 TRP C 74 REMARK 465 ASP C 75 REMARK 465 LEU C 76 REMARK 465 ASP C 77 REMARK 465 SER C 78 REMARK 465 LEU C 79 REMARK 465 ILE C 80 REMARK 465 ASP C 81 REMARK 465 PRO C 82 REMARK 465 ASP C 83 REMARK 465 ARG C 84 REMARK 465 GLU C 85 REMARK 465 ARG C 86 REMARK 465 ALA C 87 REMARK 465 GLY C 88 REMARK 465 THR C 89 REMARK 465 SER C 90 REMARK 465 TYR C 91 REMARK 465 VAL C 92 REMARK 465 GLY C 93 REMARK 465 GLN C 94 REMARK 465 GLY C 95 REMARK 465 GLY C 96 REMARK 465 PHE C 97 REMARK 465 LEU C 98 REMARK 465 HIS C 99 REMARK 465 ASP C 100 REMARK 465 ALA C 101 REMARK 465 GLY C 102 REMARK 465 GLU C 103 REMARK 465 PHE C 104 REMARK 465 ASP C 105 REMARK 465 ALA C 106 REMARK 465 GLY C 107 REMARK 465 PHE C 108 REMARK 465 PHE C 109 REMARK 465 GLY C 110 REMARK 465 ILE C 111 REMARK 465 SER C 112 REMARK 465 PRO C 113 REMARK 465 ARG C 114 REMARK 465 GLU C 115 REMARK 465 ALA C 116 REMARK 465 VAL C 117 REMARK 465 ALA C 118 REMARK 465 MET C 119 REMARK 465 ASP C 120 REMARK 465 PRO C 121 REMARK 465 GLN C 122 REMARK 465 GLN C 123 REMARK 465 ARG C 124 REMARK 465 LEU C 125 REMARK 465 LEU C 126 REMARK 465 LEU C 127 REMARK 465 GLU C 128 REMARK 465 THR C 129 REMARK 465 SER C 130 REMARK 465 TRP C 131 REMARK 465 GLU C 132 REMARK 465 ALA C 133 REMARK 465 LEU C 134 REMARK 465 GLU C 135 REMARK 465 ASN C 136 REMARK 465 ALA C 137 REMARK 465 GLY C 138 REMARK 465 VAL C 139 REMARK 465 ASP C 140 REMARK 465 PRO C 141 REMARK 465 ILE C 142 REMARK 465 ALA C 143 REMARK 465 LEU C 144 REMARK 465 LYS C 145 REMARK 465 GLY C 146 REMARK 465 THR C 147 REMARK 465 ASP C 148 REMARK 465 THR C 149 REMARK 465 GLY C 150 REMARK 465 VAL C 151 REMARK 465 PHE C 152 REMARK 465 SER C 153 REMARK 465 GLY C 154 REMARK 465 LEU C 155 REMARK 465 MET C 156 REMARK 465 GLY C 157 REMARK 465 GLN C 158 REMARK 465 GLY C 159 REMARK 465 TYR C 160 REMARK 465 GLY C 161 REMARK 465 SER C 162 REMARK 465 GLY C 163 REMARK 465 ALA C 164 REMARK 465 VAL C 165 REMARK 465 ALA C 166 REMARK 465 PRO C 167 REMARK 465 GLU C 168 REMARK 465 LEU C 169 REMARK 465 GLU C 170 REMARK 465 GLY C 171 REMARK 465 PHE C 172 REMARK 465 VAL C 173 REMARK 465 THR C 174 REMARK 465 THR C 175 REMARK 465 GLY C 176 REMARK 465 VAL C 177 REMARK 465 ALA C 178 REMARK 465 SER C 179 REMARK 465 SER C 180 REMARK 465 VAL C 181 REMARK 465 ALA C 182 REMARK 465 SER C 183 REMARK 465 GLY C 184 REMARK 465 ARG C 185 REMARK 465 VAL C 186 REMARK 465 SER C 187 REMARK 465 TYR C 188 REMARK 465 VAL C 189 REMARK 465 LEU C 190 REMARK 465 GLY C 191 REMARK 465 LEU C 192 REMARK 465 GLU C 193 REMARK 465 GLY C 194 REMARK 465 PRO C 195 REMARK 465 ALA C 196 REMARK 465 VAL C 197 REMARK 465 THR C 198 REMARK 465 VAL C 199 REMARK 465 ASP C 200 REMARK 465 THR C 201 REMARK 465 ALA C 202 REMARK 465 CYS C 203 REMARK 465 SER C 204 REMARK 465 SER C 205 REMARK 465 SER C 206 REMARK 465 LEU C 207 REMARK 465 VAL C 208 REMARK 465 ALA C 209 REMARK 465 MET C 210 REMARK 465 HIS C 211 REMARK 465 LEU C 212 REMARK 465 ALA C 213 REMARK 465 ALA C 214 REMARK 465 GLN C 215 REMARK 465 ALA C 216 REMARK 465 LEU C 217 REMARK 465 ARG C 218 REMARK 465 GLN C 219 REMARK 465 GLY C 220 REMARK 465 GLU C 221 REMARK 465 CYS C 222 REMARK 465 SER C 223 REMARK 465 MET C 224 REMARK 465 ALA C 225 REMARK 465 LEU C 226 REMARK 465 ALA C 227 REMARK 465 GLY C 228 REMARK 465 GLY C 229 REMARK 465 VAL C 230 REMARK 465 THR C 231 REMARK 465 VAL C 232 REMARK 465 MET C 233 REMARK 465 ALA C 234 REMARK 465 THR C 235 REMARK 465 PRO C 236 REMARK 465 GLY C 237 REMARK 465 SER C 238 REMARK 465 PHE C 239 REMARK 465 VAL C 240 REMARK 465 GLU C 241 REMARK 465 PHE C 242 REMARK 465 SER C 243 REMARK 465 ARG C 244 REMARK 465 GLN C 245 REMARK 465 ARG C 246 REMARK 465 ALA C 247 REMARK 465 LEU C 248 REMARK 465 ALA C 249 REMARK 465 PRO C 250 REMARK 465 ASP C 251 REMARK 465 GLY C 252 REMARK 465 ARG C 253 REMARK 465 CYS C 254 REMARK 465 LYS C 255 REMARK 465 ALA C 256 REMARK 465 PHE C 257 REMARK 465 ALA C 258 REMARK 465 ALA C 259 REMARK 465 ALA C 260 REMARK 465 ALA C 261 REMARK 465 ASP C 262 REMARK 465 GLY C 263 REMARK 465 THR C 264 REMARK 465 GLY C 265 REMARK 465 TRP C 266 REMARK 465 SER C 267 REMARK 465 GLU C 268 REMARK 465 GLY C 269 REMARK 465 VAL C 270 REMARK 465 GLY C 271 REMARK 465 VAL C 272 REMARK 465 VAL C 273 REMARK 465 VAL C 274 REMARK 465 LEU C 275 REMARK 465 GLU C 276 REMARK 465 ARG C 277 REMARK 465 LEU C 278 REMARK 465 SER C 279 REMARK 465 VAL C 280 REMARK 465 ALA C 281 REMARK 465 ARG C 282 REMARK 465 GLU C 283 REMARK 465 ARG C 284 REMARK 465 GLY C 285 REMARK 465 HIS C 286 REMARK 465 ARG C 287 REMARK 465 ILE C 288 REMARK 465 LEU C 289 REMARK 465 ALA C 290 REMARK 465 VAL C 291 REMARK 465 LEU C 292 REMARK 465 ARG C 293 REMARK 465 GLY C 294 REMARK 465 SER C 295 REMARK 465 ALA C 296 REMARK 465 VAL C 297 REMARK 465 ASN C 298 REMARK 465 GLN C 299 REMARK 465 ASP C 300 REMARK 465 GLY C 301 REMARK 465 ALA C 302 REMARK 465 SER C 303 REMARK 465 ASN C 304 REMARK 465 GLY C 305 REMARK 465 LEU C 306 REMARK 465 THR C 307 REMARK 465 ALA C 308 REMARK 465 PRO C 309 REMARK 465 ASN C 310 REMARK 465 GLY C 311 REMARK 465 LEU C 312 REMARK 465 SER C 313 REMARK 465 GLN C 314 REMARK 465 GLN C 315 REMARK 465 ARG C 316 REMARK 465 VAL C 317 REMARK 465 ILE C 318 REMARK 465 ARG C 319 REMARK 465 ARG C 320 REMARK 465 ALA C 321 REMARK 465 LEU C 322 REMARK 465 ALA C 323 REMARK 465 ALA C 324 REMARK 465 ALA C 325 REMARK 465 GLY C 326 REMARK 465 LEU C 327 REMARK 465 ALA C 328 REMARK 465 PRO C 329 REMARK 465 SER C 330 REMARK 465 ASP C 331 REMARK 465 VAL C 332 REMARK 465 ASP C 333 REMARK 465 VAL C 334 REMARK 465 VAL C 335 REMARK 465 GLU C 336 REMARK 465 ALA C 337 REMARK 465 HIS C 338 REMARK 465 GLY C 339 REMARK 465 THR C 340 REMARK 465 GLY C 341 REMARK 465 THR C 342 REMARK 465 THR C 343 REMARK 465 LEU C 344 REMARK 465 GLY C 345 REMARK 465 ASP C 346 REMARK 465 PRO C 347 REMARK 465 ILE C 348 REMARK 465 GLU C 349 REMARK 465 ALA C 350 REMARK 465 GLN C 351 REMARK 465 ALA C 352 REMARK 465 LEU C 353 REMARK 465 LEU C 354 REMARK 465 ALA C 355 REMARK 465 THR C 356 REMARK 465 TYR C 357 REMARK 465 GLY C 358 REMARK 465 GLN C 359 REMARK 465 GLU C 360 REMARK 465 ARG C 361 REMARK 465 LYS C 362 REMARK 465 GLN C 363 REMARK 465 PRO C 364 REMARK 465 LEU C 365 REMARK 465 TRP C 366 REMARK 465 LEU C 367 REMARK 465 GLY C 368 REMARK 465 SER C 369 REMARK 465 LEU C 370 REMARK 465 LYS C 371 REMARK 465 SER C 372 REMARK 465 ASN C 373 REMARK 465 ILE C 374 REMARK 465 GLY C 375 REMARK 465 HIS C 376 REMARK 465 ALA C 377 REMARK 465 GLN C 378 REMARK 465 ALA C 379 REMARK 465 ALA C 380 REMARK 465 ALA C 381 REMARK 465 GLY C 382 REMARK 465 VAL C 383 REMARK 465 ALA C 384 REMARK 465 GLY C 385 REMARK 465 VAL C 386 REMARK 465 ILE C 387 REMARK 465 LYS C 388 REMARK 465 MET C 389 REMARK 465 VAL C 390 REMARK 465 GLN C 391 REMARK 465 ALA C 392 REMARK 465 LEU C 393 REMARK 465 ARG C 394 REMARK 465 HIS C 395 REMARK 465 GLU C 396 REMARK 465 THR C 397 REMARK 465 LEU C 398 REMARK 465 PRO C 399 REMARK 465 PRO C 400 REMARK 465 THR C 401 REMARK 465 LEU C 402 REMARK 465 HIS C 403 REMARK 465 VAL C 404 REMARK 465 ASP C 405 REMARK 465 LYS C 406 REMARK 465 PRO C 407 REMARK 465 THR C 408 REMARK 465 LEU C 409 REMARK 465 GLU C 410 REMARK 465 VAL C 411 REMARK 465 ASP C 412 REMARK 465 TRP C 413 REMARK 465 SER C 414 REMARK 465 ALA C 415 REMARK 465 GLY C 416 REMARK 465 ALA C 417 REMARK 465 ILE C 418 REMARK 465 GLU C 419 REMARK 465 LEU C 420 REMARK 465 LEU C 421 REMARK 465 THR C 422 REMARK 465 GLU C 423 REMARK 465 ALA C 424 REMARK 465 ARG C 425 REMARK 465 ALA C 426 REMARK 465 TRP C 427 REMARK 465 PRO C 428 REMARK 465 ARG C 429 REMARK 465 ASN C 430 REMARK 465 GLY C 431 REMARK 465 ARG C 432 REMARK 465 PRO C 433 REMARK 465 ARG C 434 REMARK 465 ARG C 435 REMARK 465 ALA C 436 REMARK 465 GLY C 437 REMARK 465 VAL C 438 REMARK 465 SER C 439 REMARK 465 SER C 440 REMARK 465 PHE C 441 REMARK 465 GLY C 442 REMARK 465 VAL C 443 REMARK 465 SER C 444 REMARK 465 GLY C 445 REMARK 465 THR C 446 REMARK 465 ASN C 447 REMARK 465 ALA C 448 REMARK 465 HIS C 449 REMARK 465 LEU C 450 REMARK 465 ILE C 451 REMARK 465 LEU C 452 REMARK 465 GLU C 453 REMARK 465 GLU C 454 REMARK 465 ALA C 455 REMARK 465 PRO C 456 REMARK 465 ALA C 457 REMARK 465 GLU C 458 REMARK 465 GLU C 459 REMARK 465 PRO C 460 REMARK 465 VAL C 461 REMARK 465 ALA C 462 REMARK 465 ALA C 463 REMARK 465 PRO C 464 REMARK 465 GLU C 465 REMARK 465 LEU C 466 REMARK 465 PRO C 467 REMARK 465 VAL C 468 REMARK 465 VAL C 469 REMARK 465 PRO C 470 REMARK 465 LEU C 471 REMARK 465 VAL C 472 REMARK 465 VAL C 473 REMARK 465 SER C 474 REMARK 465 ALA C 475 REMARK 465 ARG C 476 REMARK 465 SER C 477 REMARK 465 THR C 478 REMARK 465 GLU C 479 REMARK 465 SER C 480 REMARK 465 LEU C 481 REMARK 465 SER C 482 REMARK 465 GLY C 483 REMARK 465 GLN C 484 REMARK 465 ALA C 485 REMARK 465 GLU C 486 REMARK 465 ARG C 487 REMARK 465 LEU C 488 REMARK 465 ALA C 489 REMARK 465 SER C 490 REMARK 465 LEU C 491 REMARK 465 LEU C 492 REMARK 465 GLU C 493 REMARK 465 GLY C 494 REMARK 465 ASP C 495 REMARK 465 VAL C 496 REMARK 465 SER C 497 REMARK 465 LEU C 498 REMARK 465 THR C 499 REMARK 465 GLU C 500 REMARK 465 VAL C 501 REMARK 465 ALA C 502 REMARK 465 GLY C 503 REMARK 465 ALA C 504 REMARK 465 LEU C 505 REMARK 465 VAL C 506 REMARK 465 SER C 507 REMARK 465 ARG C 508 REMARK 465 ARG C 509 REMARK 465 ALA C 510 REMARK 465 VAL C 511 REMARK 465 LEU C 512 REMARK 465 ASP C 513 REMARK 465 GLU C 514 REMARK 465 ARG C 515 REMARK 465 ALA C 516 REMARK 465 VAL C 517 REMARK 465 VAL C 518 REMARK 465 VAL C 519 REMARK 465 ALA C 520 REMARK 465 GLY C 521 REMARK 465 SER C 522 REMARK 465 ARG C 523 REMARK 465 GLU C 524 REMARK 465 GLU C 525 REMARK 465 ALA C 526 REMARK 465 VAL C 527 REMARK 465 THR C 528 REMARK 465 GLY C 529 REMARK 465 LEU C 530 REMARK 465 ARG C 531 REMARK 465 ALA C 532 REMARK 465 LEU C 533 REMARK 465 ASN C 534 REMARK 465 THR C 535 REMARK 465 ALA C 536 REMARK 465 GLY C 537 REMARK 465 SER C 538 REMARK 465 GLY C 539 REMARK 465 THR C 540 REMARK 465 PRO C 541 REMARK 465 GLY C 542 REMARK 465 LYS C 543 REMARK 465 VAL C 544 REMARK 465 VAL C 545 REMARK 465 TRP C 546 REMARK 465 VAL C 547 REMARK 465 PHE C 548 REMARK 465 PRO C 549 REMARK 465 GLY C 550 REMARK 465 GLN C 551 REMARK 465 GLY C 552 REMARK 465 THR C 553 REMARK 465 GLN C 554 REMARK 465 TRP C 555 REMARK 465 ALA C 556 REMARK 465 GLY C 557 REMARK 465 MET C 558 REMARK 465 GLY C 559 REMARK 465 ARG C 560 REMARK 465 GLU C 561 REMARK 465 LEU C 562 REMARK 465 LEU C 563 REMARK 465 ALA C 564 REMARK 465 GLU C 565 REMARK 465 SER C 566 REMARK 465 PRO C 567 REMARK 465 VAL C 568 REMARK 465 PHE C 569 REMARK 465 ALA C 570 REMARK 465 GLU C 571 REMARK 465 ARG C 572 REMARK 465 ILE C 573 REMARK 465 ALA C 574 REMARK 465 GLU C 575 REMARK 465 CYS C 576 REMARK 465 ALA C 577 REMARK 465 ALA C 578 REMARK 465 ALA C 579 REMARK 465 LEU C 580 REMARK 465 ALA C 581 REMARK 465 PRO C 582 REMARK 465 TRP C 583 REMARK 465 ILE C 584 REMARK 465 ASP C 585 REMARK 465 TRP C 586 REMARK 465 SER C 587 REMARK 465 LEU C 588 REMARK 465 VAL C 589 REMARK 465 ASP C 590 REMARK 465 VAL C 591 REMARK 465 LEU C 592 REMARK 465 ARG C 593 REMARK 465 GLY C 594 REMARK 465 GLU C 595 REMARK 465 GLY C 596 REMARK 465 ASP C 597 REMARK 465 LEU C 598 REMARK 465 GLY C 599 REMARK 465 ARG C 600 REMARK 465 VAL C 601 REMARK 465 ASP C 602 REMARK 465 VAL C 603 REMARK 465 LEU C 604 REMARK 465 GLN C 605 REMARK 465 PRO C 606 REMARK 465 ALA C 607 REMARK 465 CYS C 608 REMARK 465 PHE C 609 REMARK 465 ALA C 610 REMARK 465 VAL C 611 REMARK 465 MET C 612 REMARK 465 VAL C 613 REMARK 465 GLY C 614 REMARK 465 LEU C 615 REMARK 465 ALA C 616 REMARK 465 ALA C 617 REMARK 465 VAL C 618 REMARK 465 TRP C 619 REMARK 465 GLU C 620 REMARK 465 SER C 621 REMARK 465 VAL C 622 REMARK 465 GLY C 623 REMARK 465 VAL C 624 REMARK 465 ARG C 625 REMARK 465 PRO C 626 REMARK 465 ASP C 627 REMARK 465 ALA C 628 REMARK 465 VAL C 629 REMARK 465 VAL C 630 REMARK 465 GLY C 631 REMARK 465 HIS C 632 REMARK 465 SER C 633 REMARK 465 GLN C 634 REMARK 465 GLY C 635 REMARK 465 GLU C 636 REMARK 465 ILE C 637 REMARK 465 ALA C 638 REMARK 465 ALA C 639 REMARK 465 ALA C 640 REMARK 465 CYS C 641 REMARK 465 VAL C 642 REMARK 465 SER C 643 REMARK 465 GLY C 644 REMARK 465 ALA C 645 REMARK 465 LEU C 646 REMARK 465 SER C 647 REMARK 465 LEU C 648 REMARK 465 GLU C 649 REMARK 465 ASP C 650 REMARK 465 ALA C 651 REMARK 465 ALA C 652 REMARK 465 LYS C 653 REMARK 465 VAL C 654 REMARK 465 VAL C 655 REMARK 465 ALA C 656 REMARK 465 LEU C 657 REMARK 465 ARG C 658 REMARK 465 SER C 659 REMARK 465 GLN C 660 REMARK 465 ALA C 661 REMARK 465 ILE C 662 REMARK 465 ALA C 663 REMARK 465 ALA C 664 REMARK 465 GLU C 665 REMARK 465 LEU C 666 REMARK 465 SER C 667 REMARK 465 GLY C 668 REMARK 465 ARG C 669 REMARK 465 GLY C 670 REMARK 465 GLY C 671 REMARK 465 MET C 672 REMARK 465 ALA C 673 REMARK 465 SER C 674 REMARK 465 VAL C 675 REMARK 465 ALA C 676 REMARK 465 LEU C 677 REMARK 465 GLY C 678 REMARK 465 GLU C 679 REMARK 465 ASP C 680 REMARK 465 ASP C 681 REMARK 465 VAL C 682 REMARK 465 VAL C 683 REMARK 465 SER C 684 REMARK 465 ARG C 685 REMARK 465 LEU C 686 REMARK 465 VAL C 687 REMARK 465 ASP C 688 REMARK 465 GLY C 689 REMARK 465 VAL C 690 REMARK 465 GLU C 691 REMARK 465 VAL C 692 REMARK 465 ALA C 693 REMARK 465 ALA C 694 REMARK 465 VAL C 695 REMARK 465 ASN C 696 REMARK 465 GLY C 697 REMARK 465 PRO C 698 REMARK 465 SER C 699 REMARK 465 SER C 700 REMARK 465 VAL C 701 REMARK 465 VAL C 702 REMARK 465 ILE C 703 REMARK 465 ALA C 704 REMARK 465 GLY C 705 REMARK 465 ASP C 706 REMARK 465 ALA C 707 REMARK 465 HIS C 708 REMARK 465 ALA C 709 REMARK 465 LEU C 710 REMARK 465 ASP C 711 REMARK 465 ALA C 712 REMARK 465 THR C 713 REMARK 465 LEU C 714 REMARK 465 GLU C 715 REMARK 465 ILE C 716 REMARK 465 LEU C 717 REMARK 465 SER C 718 REMARK 465 GLY C 719 REMARK 465 GLU C 720 REMARK 465 GLY C 721 REMARK 465 ILE C 722 REMARK 465 ARG C 723 REMARK 465 VAL C 724 REMARK 465 ARG C 725 REMARK 465 ARG C 726 REMARK 465 VAL C 727 REMARK 465 ALA C 728 REMARK 465 VAL C 729 REMARK 465 ASP C 730 REMARK 465 TYR C 731 REMARK 465 ALA C 732 REMARK 465 SER C 733 REMARK 465 HIS C 734 REMARK 465 THR C 735 REMARK 465 ARG C 736 REMARK 465 HIS C 737 REMARK 465 VAL C 738 REMARK 465 GLU C 739 REMARK 465 ASP C 740 REMARK 465 ILE C 741 REMARK 465 ARG C 742 REMARK 465 ASP C 743 REMARK 465 THR C 744 REMARK 465 LEU C 745 REMARK 465 ALA C 746 REMARK 465 GLU C 747 REMARK 465 THR C 748 REMARK 465 LEU C 749 REMARK 465 ALA C 750 REMARK 465 GLY C 751 REMARK 465 ILE C 752 REMARK 465 SER C 753 REMARK 465 ALA C 754 REMARK 465 GLN C 755 REMARK 465 ALA C 756 REMARK 465 PRO C 757 REMARK 465 ALA C 758 REMARK 465 VAL C 759 REMARK 465 PRO C 760 REMARK 465 PHE C 761 REMARK 465 TYR C 762 REMARK 465 SER C 763 REMARK 465 THR C 764 REMARK 465 VAL C 765 REMARK 465 THR C 766 REMARK 465 SER C 767 REMARK 465 GLU C 768 REMARK 465 TRP C 769 REMARK 465 VAL C 770 REMARK 465 ARG C 771 REMARK 465 ASP C 772 REMARK 465 ALA C 773 REMARK 465 GLY C 774 REMARK 465 VAL C 775 REMARK 465 LEU C 776 REMARK 465 ASP C 777 REMARK 465 GLY C 778 REMARK 465 GLY C 779 REMARK 465 TYR C 780 REMARK 465 TRP C 781 REMARK 465 TYR C 782 REMARK 465 ARG C 783 REMARK 465 ASN C 784 REMARK 465 LEU C 785 REMARK 465 ARG C 786 REMARK 465 ASN C 787 REMARK 465 GLN C 788 REMARK 465 VAL C 789 REMARK 465 ARG C 790 REMARK 465 PHE C 791 REMARK 465 GLY C 792 REMARK 465 ALA C 793 REMARK 465 ALA C 794 REMARK 465 ALA C 795 REMARK 465 THR C 796 REMARK 465 ALA C 797 REMARK 465 LEU C 798 REMARK 465 LEU C 799 REMARK 465 GLU C 800 REMARK 465 GLN C 801 REMARK 465 GLY C 802 REMARK 465 HIS C 803 REMARK 465 THR C 804 REMARK 465 VAL C 805 REMARK 465 PHE C 806 REMARK 465 VAL C 807 REMARK 465 GLU C 808 REMARK 465 VAL C 809 REMARK 465 SER C 810 REMARK 465 ALA C 811 REMARK 465 HIS C 812 REMARK 465 PRO C 813 REMARK 465 VAL C 814 REMARK 465 THR C 815 REMARK 465 VAL C 816 REMARK 465 GLN C 817 REMARK 465 PRO C 818 REMARK 465 LEU C 819 REMARK 465 SER C 820 REMARK 465 GLU C 821 REMARK 465 LEU C 822 REMARK 465 THR C 823 REMARK 465 GLY C 824 REMARK 465 ASP C 825 REMARK 465 ALA C 826 REMARK 465 ILE C 827 REMARK 465 GLY C 828 REMARK 465 THR C 829 REMARK 465 LEU C 830 REMARK 465 ARG C 831 REMARK 465 ARG C 832 REMARK 465 GLU C 833 REMARK 465 ASP C 834 REMARK 465 GLY C 835 REMARK 465 GLY C 836 REMARK 465 LEU C 837 REMARK 465 ARG C 838 REMARK 465 ARG C 839 REMARK 465 LEU C 840 REMARK 465 LEU C 841 REMARK 465 ALA C 842 REMARK 465 SER C 843 REMARK 465 MET C 844 REMARK 465 GLY C 845 REMARK 465 GLU C 846 REMARK 465 LEU C 847 REMARK 465 PHE C 848 REMARK 465 VAL C 849 REMARK 465 ARG C 850 REMARK 465 GLY C 851 REMARK 465 ILE C 852 REMARK 465 ASP C 853 REMARK 465 VAL C 854 REMARK 465 ASP C 855 REMARK 465 TRP C 856 REMARK 465 THR C 857 REMARK 465 ALA C 858 REMARK 465 MET C 859 REMARK 465 VAL C 860 REMARK 465 PRO C 861 REMARK 465 ALA C 862 REMARK 465 ALA C 863 REMARK 465 GLY C 864 REMARK 465 TRP C 865 REMARK 465 VAL C 866 REMARK 465 ASP C 867 REMARK 465 LEU C 868 REMARK 465 PRO C 869 REMARK 465 THR C 870 REMARK 465 TYR C 871 REMARK 465 ALA C 872 REMARK 465 PHE C 873 REMARK 465 GLU C 874 REMARK 465 HIS C 875 REMARK 465 ARG C 876 REMARK 465 HIS C 877 REMARK 465 TYR C 878 REMARK 465 TRP C 879 REMARK 465 LEU C 880 REMARK 465 GLU C 881 REMARK 465 PRO C 882 REMARK 465 ALA C 883 REMARK 465 GLU C 884 REMARK 465 PRO C 885 REMARK 465 ALA C 886 REMARK 465 SER C 887 REMARK 465 ALA C 888 REMARK 465 GLY C 889 REMARK 465 ASP C 890 REMARK 465 PRO C 891 REMARK 465 LEU C 892 REMARK 465 LEU C 893 REMARK 465 GLY C 894 REMARK 465 THR C 895 REMARK 465 VAL C 896 REMARK 465 VAL C 897 REMARK 465 SER C 898 REMARK 465 THR C 899 REMARK 465 PRO C 900 REMARK 465 GLY C 901 REMARK 465 SER C 902 REMARK 465 ASP C 903 REMARK 465 ARG C 904 REMARK 465 LEU C 905 REMARK 465 THR C 906 REMARK 465 ALA C 907 REMARK 465 VAL C 908 REMARK 465 ALA C 909 REMARK 465 GLN C 910 REMARK 465 TRP C 911 REMARK 465 SER C 912 REMARK 465 ARG C 913 REMARK 465 ARG C 914 REMARK 465 ALA C 915 REMARK 465 GLN C 916 REMARK 465 PRO C 917 REMARK 465 TRP C 918 REMARK 465 ALA C 919 REMARK 465 VAL C 920 REMARK 465 ASP C 921 REMARK 465 GLY C 922 REMARK 465 LEU C 923 REMARK 465 VAL C 924 REMARK 465 PRO C 925 REMARK 465 ASN C 926 REMARK 465 ALA C 927 REMARK 465 ALA C 928 REMARK 465 LEU C 929 REMARK 465 VAL C 930 REMARK 465 GLU C 931 REMARK 465 ALA C 932 REMARK 465 ALA C 933 REMARK 465 ILE C 934 REMARK 465 ARG C 935 REMARK 465 LEU C 936 REMARK 465 GLY C 937 REMARK 465 ASP C 938 REMARK 465 LEU C 939 REMARK 465 ALA C 940 REMARK 465 GLY C 941 REMARK 465 THR C 942 REMARK 465 PRO C 943 REMARK 465 VAL C 944 REMARK 465 VAL C 945 REMARK 465 GLY C 946 REMARK 465 GLU C 947 REMARK 465 LEU C 948 REMARK 465 VAL C 949 REMARK 465 VAL C 950 REMARK 465 ASP C 951 REMARK 465 ALA C 952 REMARK 465 PRO C 953 REMARK 465 VAL C 954 REMARK 465 VAL C 955 REMARK 465 LEU C 956 REMARK 465 PRO C 957 REMARK 465 ARG C 958 REMARK 465 ARG C 959 REMARK 465 GLY C 960 REMARK 465 SER C 961 REMARK 465 ARG C 962 REMARK 465 GLU C 963 REMARK 465 VAL C 964 REMARK 465 GLN C 965 REMARK 465 LEU C 966 REMARK 465 ILE C 967 REMARK 465 VAL C 968 REMARK 465 GLY C 969 REMARK 465 GLU C 970 REMARK 465 PRO C 971 REMARK 465 GLY C 972 REMARK 465 GLU C 973 REMARK 465 GLN C 974 REMARK 465 ARG C 975 REMARK 465 ARG C 976 REMARK 465 ARG C 977 REMARK 465 PRO C 978 REMARK 465 ILE C 979 REMARK 465 GLU C 980 REMARK 465 VAL C 981 REMARK 465 PHE C 982 REMARK 465 SER C 983 REMARK 465 ARG C 984 REMARK 465 GLU C 985 REMARK 465 ALA C 986 REMARK 465 ASP C 987 REMARK 465 GLU C 988 REMARK 465 PRO C 989 REMARK 465 TRP C 990 REMARK 465 THR C 991 REMARK 465 ARG C 992 REMARK 465 HIS C 993 REMARK 465 ALA C 994 REMARK 465 HIS C 995 REMARK 465 GLY C 996 REMARK 465 THR C 997 REMARK 465 LEU C 998 REMARK 465 ALA C 999 REMARK 465 PRO C 1000 REMARK 465 ALA C 1001 REMARK 465 ALA C 1002 REMARK 465 ALA C 1003 REMARK 465 ALA C 1004 REMARK 465 VAL C 1005 REMARK 465 PRO C 1006 REMARK 465 GLU C 1007 REMARK 465 PRO C 1008 REMARK 465 ALA C 1009 REMARK 465 ALA C 1010 REMARK 465 ALA C 1011 REMARK 465 GLY C 1012 REMARK 465 ASP C 1013 REMARK 465 ALA C 1014 REMARK 465 THR C 1015 REMARK 465 ASP C 1016 REMARK 465 VAL C 1017 REMARK 465 THR C 1018 REMARK 465 VAL C 1019 REMARK 465 ALA C 1020 REMARK 465 GLY C 1021 REMARK 465 LEU C 1022 REMARK 465 ARG C 1023 REMARK 465 ASP C 1024 REMARK 465 ALA C 1025 REMARK 465 ASP C 1026 REMARK 465 ARG C 1027 REMARK 465 TYR C 1028 REMARK 465 GLY C 1029 REMARK 465 ILE C 1030 REMARK 465 HIS C 1031 REMARK 465 PRO C 1032 REMARK 465 ALA C 1033 REMARK 465 LEU C 1034 REMARK 465 LEU C 1035 REMARK 465 ASP C 1036 REMARK 465 ALA C 1037 REMARK 465 ALA C 1038 REMARK 465 VAL C 1039 REMARK 465 ARG C 1040 REMARK 465 THR C 1041 REMARK 465 VAL C 1042 REMARK 465 VAL C 1043 REMARK 465 GLY C 1044 REMARK 465 ASP C 1045 REMARK 465 ASP C 1046 REMARK 465 LEU C 1047 REMARK 465 LEU C 1048 REMARK 465 PRO C 1049 REMARK 465 SER C 1050 REMARK 465 VAL C 1051 REMARK 465 TRP C 1052 REMARK 465 THR C 1053 REMARK 465 GLY C 1054 REMARK 465 VAL C 1055 REMARK 465 SER C 1056 REMARK 465 LEU C 1057 REMARK 465 LEU C 1058 REMARK 465 ALA C 1059 REMARK 465 SER C 1060 REMARK 465 GLY C 1061 REMARK 465 ALA C 1062 REMARK 465 THR C 1063 REMARK 465 ALA C 1064 REMARK 465 VAL C 1065 REMARK 465 THR C 1066 REMARK 465 VAL C 1067 REMARK 465 THR C 1068 REMARK 465 PRO C 1069 REMARK 465 THR C 1070 REMARK 465 ALA C 1071 REMARK 465 THR C 1072 REMARK 465 GLY C 1073 REMARK 465 LEU C 1074 REMARK 465 ARG C 1075 REMARK 465 LEU C 1076 REMARK 465 THR C 1077 REMARK 465 ASP C 1078 REMARK 465 PRO C 1079 REMARK 465 ALA C 1080 REMARK 465 GLY C 1081 REMARK 465 GLN C 1082 REMARK 465 PRO C 1083 REMARK 465 VAL C 1084 REMARK 465 LEU C 1085 REMARK 465 THR C 1086 REMARK 465 VAL C 1087 REMARK 465 GLU C 1088 REMARK 465 SER C 1089 REMARK 465 VAL C 1090 REMARK 465 ARG C 1091 REMARK 465 GLY C 1092 REMARK 465 THR C 1093 REMARK 465 PRO C 1094 REMARK 465 PHE C 1095 REMARK 465 VAL C 1096 REMARK 465 ALA C 1097 REMARK 465 GLU C 1098 REMARK 465 GLN C 1099 REMARK 465 GLY C 1100 REMARK 465 THR C 1101 REMARK 465 THR C 1102 REMARK 465 ASP C 1103 REMARK 465 ALA C 1104 REMARK 465 LEU C 1105 REMARK 465 PHE C 1106 REMARK 465 ARG C 1107 REMARK 465 VAL C 1108 REMARK 465 ASP C 1109 REMARK 465 TRP C 1110 REMARK 465 PRO C 1111 REMARK 465 GLU C 1112 REMARK 465 ILE C 1113 REMARK 465 PRO C 1114 REMARK 465 LEU C 1115 REMARK 465 PRO C 1116 REMARK 465 THR C 1117 REMARK 465 ALA C 1118 REMARK 465 GLU C 1119 REMARK 465 THR C 1120 REMARK 465 ALA C 1121 REMARK 465 ASP C 1122 REMARK 465 PHE C 1123 REMARK 465 LEU C 1124 REMARK 465 PRO C 1125 REMARK 465 TYR C 1126 REMARK 465 GLU C 1127 REMARK 465 ALA C 1128 REMARK 465 THR C 1129 REMARK 465 SER C 1130 REMARK 465 ALA C 1131 REMARK 465 GLU C 1132 REMARK 465 ALA C 1133 REMARK 465 THR C 1134 REMARK 465 LEU C 1135 REMARK 465 SER C 1136 REMARK 465 ALA C 1137 REMARK 465 LEU C 1138 REMARK 465 GLN C 1139 REMARK 465 ALA C 1140 REMARK 465 TRP C 1141 REMARK 465 LEU C 1142 REMARK 465 ALA C 1143 REMARK 465 ASP C 1144 REMARK 465 PRO C 1145 REMARK 465 ALA C 1146 REMARK 465 GLU C 1147 REMARK 465 THR C 1148 REMARK 465 ARG C 1149 REMARK 465 LEU C 1150 REMARK 465 ALA C 1151 REMARK 465 VAL C 1152 REMARK 465 VAL C 1153 REMARK 465 THR C 1154 REMARK 465 GLY C 1155 REMARK 465 ASP C 1156 REMARK 465 CYS C 1157 REMARK 465 THR C 1158 REMARK 465 GLU C 1159 REMARK 465 PRO C 1160 REMARK 465 GLY C 1161 REMARK 465 ALA C 1162 REMARK 465 ALA C 1163 REMARK 465 ALA C 1164 REMARK 465 ILE C 1165 REMARK 465 TRP C 1166 REMARK 465 GLY C 1167 REMARK 465 LEU C 1168 REMARK 465 VAL C 1169 REMARK 465 ARG C 1170 REMARK 465 SER C 1171 REMARK 465 ALA C 1172 REMARK 465 GLN C 1173 REMARK 465 SER C 1174 REMARK 465 GLU C 1175 REMARK 465 HIS C 1176 REMARK 465 PRO C 1177 REMARK 465 GLY C 1178 REMARK 465 ARG C 1179 REMARK 465 ILE C 1180 REMARK 465 VAL C 1181 REMARK 465 LEU C 1182 REMARK 465 ALA C 1183 REMARK 465 ASP C 1184 REMARK 465 LEU C 1185 REMARK 465 ASP C 1186 REMARK 465 ASP C 1187 REMARK 465 PRO C 1188 REMARK 465 ALA C 1189 REMARK 465 VAL C 1190 REMARK 465 LEU C 1191 REMARK 465 PRO C 1192 REMARK 465 ALA C 1193 REMARK 465 VAL C 1194 REMARK 465 VAL C 1195 REMARK 465 ALA C 1196 REMARK 465 SER C 1197 REMARK 465 GLY C 1198 REMARK 465 GLU C 1199 REMARK 465 PRO C 1200 REMARK 465 GLN C 1201 REMARK 465 VAL C 1202 REMARK 465 ARG C 1203 REMARK 465 VAL C 1204 REMARK 465 ARG C 1205 REMARK 465 ASN C 1206 REMARK 465 GLY C 1207 REMARK 465 VAL C 1208 REMARK 465 ALA C 1209 REMARK 465 SER C 1210 REMARK 465 VAL C 1211 REMARK 465 PRO C 1212 REMARK 465 ARG C 1213 REMARK 465 LEU C 1214 REMARK 465 THR C 1215 REMARK 465 ARG C 1216 REMARK 465 VAL C 1217 REMARK 465 THR C 1218 REMARK 465 PRO C 1219 REMARK 465 ARG C 1220 REMARK 465 GLN C 1221 REMARK 465 ASP C 1222 REMARK 465 ALA C 1223 REMARK 465 ARG C 1224 REMARK 465 PRO C 1225 REMARK 465 LEU C 1226 REMARK 465 ASP C 1227 REMARK 465 PRO C 1228 REMARK 465 GLU C 1229 REMARK 465 GLY C 1230 REMARK 465 THR C 1231 REMARK 465 VAL C 1232 REMARK 465 LEU C 1233 REMARK 465 ILE C 1234 REMARK 465 THR C 1235 REMARK 465 GLY C 1236 REMARK 465 GLY C 1237 REMARK 465 THR C 1238 REMARK 465 GLY C 1239 REMARK 465 THR C 1240 REMARK 465 LEU C 1241 REMARK 465 GLY C 1242 REMARK 465 ALA C 1243 REMARK 465 LEU C 1244 REMARK 465 THR C 1245 REMARK 465 ALA C 1246 REMARK 465 ARG C 1247 REMARK 465 HIS C 1248 REMARK 465 LEU C 1249 REMARK 465 VAL C 1250 REMARK 465 THR C 1251 REMARK 465 ALA C 1252 REMARK 465 HIS C 1253 REMARK 465 GLY C 1254 REMARK 465 VAL C 1255 REMARK 465 ARG C 1256 REMARK 465 HIS C 1257 REMARK 465 LEU C 1258 REMARK 465 VAL C 1259 REMARK 465 LEU C 1260 REMARK 465 VAL C 1261 REMARK 465 SER C 1262 REMARK 465 ARG C 1263 REMARK 465 ARG C 1264 REMARK 465 GLY C 1265 REMARK 465 GLU C 1266 REMARK 465 ALA C 1267 REMARK 465 PRO C 1268 REMARK 465 GLU C 1269 REMARK 465 LEU C 1270 REMARK 465 GLN C 1271 REMARK 465 GLU C 1272 REMARK 465 GLU C 1273 REMARK 465 LEU C 1274 REMARK 465 THR C 1275 REMARK 465 ALA C 1276 REMARK 465 LEU C 1277 REMARK 465 GLY C 1278 REMARK 465 ALA C 1279 REMARK 465 SER C 1280 REMARK 465 VAL C 1281 REMARK 465 ALA C 1282 REMARK 465 ILE C 1283 REMARK 465 ALA C 1284 REMARK 465 ALA C 1285 REMARK 465 CYS C 1286 REMARK 465 ASP C 1287 REMARK 465 VAL C 1288 REMARK 465 ALA C 1289 REMARK 465 ASP C 1290 REMARK 465 ARG C 1291 REMARK 465 ALA C 1292 REMARK 465 GLN C 1293 REMARK 465 LEU C 1294 REMARK 465 GLU C 1295 REMARK 465 ALA C 1296 REMARK 465 VAL C 1297 REMARK 465 LEU C 1298 REMARK 465 ARG C 1299 REMARK 465 ALA C 1300 REMARK 465 ILE C 1301 REMARK 465 PRO C 1302 REMARK 465 ALA C 1303 REMARK 465 GLU C 1304 REMARK 465 HIS C 1305 REMARK 465 PRO C 1306 REMARK 465 LEU C 1307 REMARK 465 THR C 1308 REMARK 465 ALA C 1309 REMARK 465 VAL C 1310 REMARK 465 ILE C 1311 REMARK 465 HIS C 1312 REMARK 465 THR C 1313 REMARK 465 ALA C 1314 REMARK 465 GLY C 1315 REMARK 465 VAL C 1316 REMARK 465 LEU C 1317 REMARK 465 ASP C 1318 REMARK 465 ASP C 1319 REMARK 465 GLY C 1320 REMARK 465 VAL C 1321 REMARK 465 VAL C 1322 REMARK 465 THR C 1323 REMARK 465 GLU C 1324 REMARK 465 LEU C 1325 REMARK 465 THR C 1326 REMARK 465 PRO C 1327 REMARK 465 ASP C 1328 REMARK 465 ARG C 1329 REMARK 465 LEU C 1330 REMARK 465 ALA C 1331 REMARK 465 THR C 1332 REMARK 465 VAL C 1333 REMARK 465 ARG C 1334 REMARK 465 ARG C 1335 REMARK 465 PRO C 1336 REMARK 465 LYS C 1337 REMARK 465 VAL C 1338 REMARK 465 ASP C 1339 REMARK 465 ALA C 1340 REMARK 465 ALA C 1341 REMARK 465 ARG C 1342 REMARK 465 LEU C 1343 REMARK 465 LEU C 1344 REMARK 465 ASP C 1345 REMARK 465 GLU C 1346 REMARK 465 LEU C 1347 REMARK 465 THR C 1348 REMARK 465 ARG C 1349 REMARK 465 GLU C 1350 REMARK 465 ALA C 1351 REMARK 465 ASP C 1352 REMARK 465 LEU C 1353 REMARK 465 ALA C 1354 REMARK 465 ALA C 1355 REMARK 465 PHE C 1356 REMARK 465 VAL C 1357 REMARK 465 LEU C 1358 REMARK 465 PHE C 1359 REMARK 465 SER C 1360 REMARK 465 SER C 1361 REMARK 465 ALA C 1362 REMARK 465 ALA C 1363 REMARK 465 GLY C 1364 REMARK 465 VAL C 1365 REMARK 465 LEU C 1366 REMARK 465 GLY C 1367 REMARK 465 ASN C 1368 REMARK 465 PRO C 1369 REMARK 465 GLY C 1370 REMARK 465 GLN C 1371 REMARK 465 ALA C 1372 REMARK 465 GLY C 1373 REMARK 465 TYR C 1374 REMARK 465 ALA C 1375 REMARK 465 ALA C 1376 REMARK 465 ALA C 1377 REMARK 465 ASN C 1378 REMARK 465 ALA C 1379 REMARK 465 GLU C 1380 REMARK 465 LEU C 1381 REMARK 465 ASP C 1382 REMARK 465 ALA C 1383 REMARK 465 LEU C 1384 REMARK 465 ALA C 1385 REMARK 465 ARG C 1386 REMARK 465 GLN C 1387 REMARK 465 ARG C 1388 REMARK 465 ASN C 1389 REMARK 465 SER C 1390 REMARK 465 LEU C 1391 REMARK 465 ASP C 1392 REMARK 465 LEU C 1393 REMARK 465 PRO C 1394 REMARK 465 ALA C 1395 REMARK 465 VAL C 1396 REMARK 465 SER C 1397 REMARK 465 ILE C 1398 REMARK 465 ALA C 1399 REMARK 465 TRP C 1400 REMARK 465 GLY C 1401 REMARK 465 TYR C 1402 REMARK 465 TRP C 1403 REMARK 465 ALA C 1404 REMARK 465 THR C 1405 REMARK 465 VAL C 1406 REMARK 465 SER C 1407 REMARK 465 GLY C 1408 REMARK 465 MET C 1409 REMARK 465 THR C 1410 REMARK 465 GLU C 1411 REMARK 465 HIS C 1412 REMARK 465 LEU C 1413 REMARK 465 GLY C 1414 REMARK 465 ASP C 1415 REMARK 465 ALA C 1416 REMARK 465 ASP C 1417 REMARK 465 LEU C 1418 REMARK 465 ARG C 1419 REMARK 465 ARG C 1420 REMARK 465 ASN C 1421 REMARK 465 GLN C 1422 REMARK 465 ARG C 1423 REMARK 465 ILE C 1424 REMARK 465 GLY C 1425 REMARK 465 MET C 1426 REMARK 465 SER C 1427 REMARK 465 GLY C 1428 REMARK 465 LEU C 1429 REMARK 465 PRO C 1430 REMARK 465 ALA C 1431 REMARK 465 ASP C 1432 REMARK 465 GLU C 1433 REMARK 465 GLY C 1434 REMARK 465 MET C 1435 REMARK 465 ALA C 1436 REMARK 465 LEU C 1437 REMARK 465 LEU C 1438 REMARK 465 ASP C 1439 REMARK 465 ALA C 1440 REMARK 465 ALA C 1441 REMARK 465 ILE C 1442 REMARK 465 ALA C 1443 REMARK 465 THR C 1444 REMARK 465 GLY C 1445 REMARK 465 GLY C 1446 REMARK 465 THR C 1447 REMARK 465 LEU C 1448 REMARK 465 VAL C 1449 REMARK 465 ALA C 1450 REMARK 465 ALA C 1451 REMARK 465 LYS C 1452 REMARK 465 PHE C 1453 REMARK 465 ASP C 1454 REMARK 465 VAL C 1455 REMARK 465 ALA C 1456 REMARK 465 ALA C 1457 REMARK 465 LEU C 1458 REMARK 465 ARG C 1459 REMARK 465 ALA C 1460 REMARK 465 THR C 1461 REMARK 465 ALA C 1462 REMARK 465 LYS C 1463 REMARK 465 ALA C 1464 REMARK 465 GLY C 1465 REMARK 465 GLY C 1466 REMARK 465 PRO C 1467 REMARK 465 VAL C 1468 REMARK 465 PRO C 1469 REMARK 465 PRO C 1470 REMARK 465 LEU C 1471 REMARK 465 LEU C 1472 REMARK 465 ARG C 1473 REMARK 465 GLY C 1474 REMARK 465 LEU C 1475 REMARK 465 ALA C 1476 REMARK 465 PRO C 1477 REMARK 465 LEU C 1478 REMARK 465 PRO C 1479 REMARK 465 ARG C 1480 REMARK 465 ARG C 1481 REMARK 465 ALA C 1482 REMARK 465 ALA C 1483 REMARK 465 ALA C 1484 REMARK 465 LYS C 1485 REMARK 465 THR C 1486 REMARK 465 ALA C 1487 REMARK 465 SER C 1488 REMARK 465 LEU C 1489 REMARK 465 THR C 1490 REMARK 465 GLU C 1491 REMARK 465 ARG C 1492 REMARK 465 LEU C 1493 REMARK 465 ALA C 1494 REMARK 465 GLY C 1495 REMARK 465 LEU C 1496 REMARK 465 ALA C 1497 REMARK 465 GLU C 1498 REMARK 465 THR C 1499 REMARK 465 GLU C 1500 REMARK 465 GLN C 1501 REMARK 465 LYS C 1577 REMARK 465 LEU C 1578 REMARK 465 PHE C 1579 REMARK 465 GLY C 1580 REMARK 465 THR C 1581 REMARK 465 GLU C 1582 REMARK 465 VAL C 1583 REMARK 465 ARG C 1584 REMARK 465 GLY C 1585 REMARK 465 GLU C 1586 REMARK 465 ALA C 1587 REMARK 465 PRO C 1588 REMARK 465 SER C 1589 REMARK 465 ALA C 1590 REMARK 465 LEU C 1591 REMARK 465 ALA C 1592 REMARK 465 GLY C 1593 REMARK 465 LEU C 1594 REMARK 465 ASP C 1595 REMARK 465 ALA C 1596 REMARK 465 LEU C 1597 REMARK 465 GLU C 1598 REMARK 465 ALA C 1599 REMARK 465 ALA C 1600 REMARK 465 LEU C 1601 REMARK 465 PRO C 1602 REMARK 465 GLU C 1603 REMARK 465 VAL C 1604 REMARK 465 PRO C 1605 REMARK 465 ALA C 1606 REMARK 465 THR C 1607 REMARK 465 GLU C 1608 REMARK 465 ARG C 1609 REMARK 465 GLU C 1610 REMARK 465 GLU C 1611 REMARK 465 LEU C 1612 REMARK 465 VAL C 1613 REMARK 465 GLN C 1614 REMARK 465 ARG C 1615 REMARK 465 LEU C 1616 REMARK 465 GLU C 1617 REMARK 465 ARG C 1618 REMARK 465 MET C 1619 REMARK 465 LEU C 1620 REMARK 465 ALA C 1621 REMARK 465 ALA C 1622 REMARK 465 LEU C 1623 REMARK 465 ARG C 1624 REMARK 465 PRO C 1625 REMARK 465 VAL C 1626 REMARK 465 ALA C 1627 REMARK 465 GLN C 1628 REMARK 465 ALA C 1629 REMARK 465 ALA C 1630 REMARK 465 ASP C 1631 REMARK 465 ALA C 1632 REMARK 465 SER C 1633 REMARK 465 GLY C 1634 REMARK 465 THR C 1635 REMARK 465 GLY C 1636 REMARK 465 ALA C 1637 REMARK 465 ASN C 1638 REMARK 465 PRO C 1639 REMARK 465 SER C 1640 REMARK 465 GLY C 1641 REMARK 465 ASP C 1642 REMARK 465 ASP C 1643 REMARK 465 LEU C 1644 REMARK 465 GLY C 1645 REMARK 465 GLU C 1646 REMARK 465 ALA C 1647 REMARK 465 GLY C 1648 REMARK 465 VAL C 1649 REMARK 465 ASP C 1650 REMARK 465 GLU C 1651 REMARK 465 LEU C 1652 REMARK 465 LEU C 1653 REMARK 465 GLU C 1654 REMARK 465 ALA C 1655 REMARK 465 LEU C 1656 REMARK 465 GLY C 1657 REMARK 465 ARG C 1658 REMARK 465 GLU C 1659 REMARK 465 LEU C 1660 REMARK 465 ASP C 1661 REMARK 465 GLY C 1662 REMARK 465 ASP C 1663 REMARK 465 GLY C 1664 REMARK 465 ASN C 1665 REMARK 465 SER C 1666 REMARK 465 SER C 1667 REMARK 465 SER C 1668 REMARK 465 VAL C 1669 REMARK 465 ASP C 1670 REMARK 465 LYS C 1671 REMARK 465 LEU C 1672 REMARK 465 ALA C 1673 REMARK 465 ALA C 1674 REMARK 465 ALA C 1675 REMARK 465 LEU C 1676 REMARK 465 GLU C 1677 REMARK 465 HIS C 1678 REMARK 465 HIS C 1679 REMARK 465 HIS C 1680 REMARK 465 HIS C 1681 REMARK 465 HIS C 1682 REMARK 465 HIS C 1683 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 ARG B 658 CG CD NE CZ NH1 NH2 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LEU G 145 -179.53 -172.28 REMARK 500 ASP G 151 64.55 60.18 REMARK 500 LEU I 27 79.67 -151.61 REMARK 500 ALA A 202 -127.95 64.74 REMARK 500 SER A 303 -169.64 -127.02 REMARK 500 GLN A 378 -126.92 58.04 REMARK 500 TRP A 427 73.64 -160.80 REMARK 500 SER A 633 -106.76 50.03 REMARK 500 ARG A 669 28.10 -141.10 REMARK 500 VAL A 814 -32.38 -131.60 REMARK 500 ALA A 986 -99.78 55.59 REMARK 500 ALA A1267 75.45 -159.36 REMARK 500 VAL A1365 -62.26 -104.61 REMARK 500 ASP A1392 -1.58 79.81 REMARK 500 ALA B 202 -135.96 63.66 REMARK 500 PHE B 257 17.94 58.23 REMARK 500 GLN B 378 -124.65 57.78 REMARK 500 SER B 633 -113.16 48.78 REMARK 500 ALA B 986 -104.74 53.82 REMARK 500 ASP C1537 -153.70 -128.21 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-71446 RELATED DB: EMDB REMARK 900 ANTIBODY (1B2) BOUND RIFAMYCIN SYNTHETASE MODULE 1 IN THE REMARK 900 ELONGATION MODE DBREF 9PAV H 1 249 PDB 9PAV 9PAV 1 249 DBREF 9PAV L 1 236 PDB 9PAV 9PAV 1 236 DBREF 9PAV G 1 249 PDB 9PAV 9PAV 1 249 DBREF 9PAV I 1 236 PDB 9PAV 9PAV 1 236 DBREF 9PAV A 32 1580 UNP O54666 O54666_AMYMD 631 2179 DBREF 9PAV B 32 1580 UNP O54666 O54666_AMYMD 631 2179 DBREF 9PAV C 32 1580 UNP O54666 O54666_AMYMD 631 2179 SEQADV 9PAV MET A 1 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 2 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 3 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR A 4 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 5 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 6 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 7 UNP O54666 EXPRESSION TAG SEQADV 9PAV LYS A 8 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL A 9 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 10 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 11 UNP O54666 EXPRESSION TAG SEQADV 9PAV TYR A 12 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 13 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 14 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 15 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 16 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR A 17 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 18 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 19 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 20 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 21 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 22 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 23 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 24 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN A 25 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 26 UNP O54666 EXPRESSION TAG SEQADV 9PAV ILE A 27 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 28 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 29 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 30 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 31 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR A 1581 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1582 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL A 1583 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 1584 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1585 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1586 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1587 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO A 1588 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 1589 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1590 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1591 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1592 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1593 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1594 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1595 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1596 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1597 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1598 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1599 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1600 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1601 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO A 1602 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1603 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL A 1604 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO A 1605 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1606 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR A 1607 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1608 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 1609 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1610 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1611 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1612 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL A 1613 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN A 1614 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 1615 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1616 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1617 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 1618 UNP O54666 EXPRESSION TAG SEQADV 9PAV MET A 1619 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1620 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1621 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1622 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1623 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 1624 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO A 1625 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL A 1626 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1627 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN A 1628 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1629 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1630 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1631 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1632 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 1633 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1634 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR A 1635 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1636 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1637 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASN A 1638 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO A 1639 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 1640 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1641 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1642 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1643 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1644 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1645 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1646 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1647 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1648 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL A 1649 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1650 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1651 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1652 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1653 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1654 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1655 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1656 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1657 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG A 1658 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1659 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1660 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1661 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1662 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1663 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY A 1664 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASN A 1665 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 1666 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 1667 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER A 1668 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL A 1669 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP A 1670 UNP O54666 EXPRESSION TAG SEQADV 9PAV LYS A 1671 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1672 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1673 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1674 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA A 1675 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU A 1676 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU A 1677 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS A 1678 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS A 1679 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS A 1680 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS A 1681 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS A 1682 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS A 1683 UNP O54666 EXPRESSION TAG SEQADV 9PAV MET B 1 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 2 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 3 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR B 4 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 5 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 6 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 7 UNP O54666 EXPRESSION TAG SEQADV 9PAV LYS B 8 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL B 9 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 10 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 11 UNP O54666 EXPRESSION TAG SEQADV 9PAV TYR B 12 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 13 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 14 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 15 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 16 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR B 17 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 18 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 19 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 20 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 21 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 22 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 23 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 24 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN B 25 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 26 UNP O54666 EXPRESSION TAG SEQADV 9PAV ILE B 27 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 28 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 29 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 30 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 31 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR B 1581 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1582 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL B 1583 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 1584 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1585 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1586 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1587 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO B 1588 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 1589 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1590 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1591 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1592 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1593 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1594 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1595 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1596 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1597 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1598 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1599 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1600 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1601 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO B 1602 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1603 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL B 1604 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO B 1605 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1606 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR B 1607 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1608 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 1609 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1610 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1611 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1612 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL B 1613 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN B 1614 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 1615 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1616 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1617 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 1618 UNP O54666 EXPRESSION TAG SEQADV 9PAV MET B 1619 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1620 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1621 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1622 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1623 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 1624 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO B 1625 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL B 1626 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1627 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN B 1628 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1629 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1630 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1631 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1632 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 1633 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1634 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR B 1635 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1636 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1637 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASN B 1638 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO B 1639 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 1640 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1641 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1642 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1643 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1644 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1645 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1646 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1647 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1648 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL B 1649 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1650 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1651 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1652 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1653 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1654 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1655 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1656 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1657 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG B 1658 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1659 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1660 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1661 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1662 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1663 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY B 1664 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASN B 1665 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 1666 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 1667 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER B 1668 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL B 1669 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP B 1670 UNP O54666 EXPRESSION TAG SEQADV 9PAV LYS B 1671 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1672 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1673 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1674 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA B 1675 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU B 1676 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU B 1677 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS B 1678 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS B 1679 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS B 1680 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS B 1681 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS B 1682 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS B 1683 UNP O54666 EXPRESSION TAG SEQADV 9PAV MET C 1 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 2 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 3 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR C 4 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 5 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 6 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 7 UNP O54666 EXPRESSION TAG SEQADV 9PAV LYS C 8 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL C 9 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 10 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 11 UNP O54666 EXPRESSION TAG SEQADV 9PAV TYR C 12 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 13 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 14 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 15 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 16 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR C 17 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 18 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 19 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 20 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 21 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 22 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 23 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 24 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN C 25 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 26 UNP O54666 EXPRESSION TAG SEQADV 9PAV ILE C 27 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 28 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 29 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 30 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 31 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR C 1581 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1582 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL C 1583 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 1584 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1585 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1586 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1587 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO C 1588 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 1589 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1590 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1591 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1592 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1593 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1594 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1595 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1596 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1597 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1598 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1599 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1600 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1601 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO C 1602 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1603 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL C 1604 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO C 1605 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1606 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR C 1607 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1608 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 1609 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1610 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1611 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1612 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL C 1613 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN C 1614 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 1615 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1616 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1617 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 1618 UNP O54666 EXPRESSION TAG SEQADV 9PAV MET C 1619 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1620 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1621 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1622 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1623 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 1624 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO C 1625 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL C 1626 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1627 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLN C 1628 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1629 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1630 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1631 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1632 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 1633 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1634 UNP O54666 EXPRESSION TAG SEQADV 9PAV THR C 1635 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1636 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1637 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASN C 1638 UNP O54666 EXPRESSION TAG SEQADV 9PAV PRO C 1639 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 1640 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1641 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1642 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1643 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1644 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1645 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1646 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1647 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1648 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL C 1649 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1650 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1651 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1652 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1653 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1654 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1655 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1656 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1657 UNP O54666 EXPRESSION TAG SEQADV 9PAV ARG C 1658 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1659 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1660 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1661 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1662 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1663 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLY C 1664 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASN C 1665 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 1666 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 1667 UNP O54666 EXPRESSION TAG SEQADV 9PAV SER C 1668 UNP O54666 EXPRESSION TAG SEQADV 9PAV VAL C 1669 UNP O54666 EXPRESSION TAG SEQADV 9PAV ASP C 1670 UNP O54666 EXPRESSION TAG SEQADV 9PAV LYS C 1671 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1672 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1673 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1674 UNP O54666 EXPRESSION TAG SEQADV 9PAV ALA C 1675 UNP O54666 EXPRESSION TAG SEQADV 9PAV LEU C 1676 UNP O54666 EXPRESSION TAG SEQADV 9PAV GLU C 1677 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS C 1678 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS C 1679 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS C 1680 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS C 1681 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS C 1682 UNP O54666 EXPRESSION TAG SEQADV 9PAV HIS C 1683 UNP O54666 EXPRESSION TAG SEQRES 1 H 249 MET ALA GLU VAL GLN LEU VAL GLN SER GLY GLY GLY LEU SEQRES 2 H 249 VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS THR ALA SEQRES 3 H 249 SER GLY PHE THR PHE GLY ASP TYR ALA MET SER TRP VAL SEQRES 4 H 249 ARG GLN ALA PRO GLY LYS GLY LEU GLU TRP VAL GLY PHE SEQRES 5 H 249 ILE ARG SER LYS ALA TYR GLY GLY THR THR GLU TYR ALA SEQRES 6 H 249 ALA SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASP SEQRES 7 H 249 SER LYS SER ILE ALA TYR LEU GLN MET ASN SER LEU LYS SEQRES 8 H 249 THR GLU ASP THR ALA VAL TYR TYR CYS THR ARG GLY GLY SEQRES 9 H 249 THR LEU PHE ASP TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 H 249 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 H 249 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 H 249 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 H 249 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 H 249 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 H 249 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 H 249 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 H 249 PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SEQRES 18 H 249 SER CYS ALA ALA LEU VAL PRO ARG GLY SER ALA HIS HIS SEQRES 19 H 249 HIS HIS HIS HIS ALA ALA ASP TYR LYS ASP ASP ASP ASP SEQRES 20 H 249 LYS ALA SEQRES 1 L 236 LEU PHE ALA ILE PRO LEU VAL VAL PRO PHE TYR SER HIS SEQRES 2 L 236 SER ALA LEU ASP VAL VAL MET THR GLN SER PRO LEU SER SEQRES 3 L 236 LEU PRO VAL THR PRO GLY GLU PRO ALA SER ILE SER CYS SEQRES 4 L 236 ARG SER SER GLN SER LEU LEU HIS SER ASN GLY TYR ASN SEQRES 5 L 236 TYR LEU ASP TRP TYR LEU GLN LYS PRO GLY GLN SER PRO SEQRES 6 L 236 GLN LEU LEU ILE TYR LEU GLY SER ASN ARG ALA SER GLY SEQRES 7 L 236 VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY THR ASP SEQRES 8 L 236 PHE THR LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL SEQRES 9 L 236 GLY VAL TYR TYR CYS MET GLN SER LEU GLN THR PRO ARG SEQRES 10 L 236 LEU THR PHE GLY PRO GLY THR LYS VAL ASP ILE LYS ARG SEQRES 11 L 236 THR VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER SEQRES 12 L 236 ASP GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS SEQRES 13 L 236 LEU LEU ASN ASN PHE TYR PRO ARG GLY ALA LYS VAL GLN SEQRES 14 L 236 TRP LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN SEQRES 15 L 236 GLU SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SEQRES 16 L 236 SER LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR SEQRES 17 L 236 GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN SEQRES 18 L 236 GLY LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY SEQRES 19 L 236 GLU CYS SEQRES 1 G 249 MET ALA GLU VAL GLN LEU VAL GLN SER GLY GLY GLY LEU SEQRES 2 G 249 VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS THR ALA SEQRES 3 G 249 SER GLY PHE THR PHE GLY ASP TYR ALA MET SER TRP VAL SEQRES 4 G 249 ARG GLN ALA PRO GLY LYS GLY LEU GLU TRP VAL GLY PHE SEQRES 5 G 249 ILE ARG SER LYS ALA TYR GLY GLY THR THR GLU TYR ALA SEQRES 6 G 249 ALA SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASP SEQRES 7 G 249 SER LYS SER ILE ALA TYR LEU GLN MET ASN SER LEU LYS SEQRES 8 G 249 THR GLU ASP THR ALA VAL TYR TYR CYS THR ARG GLY GLY SEQRES 9 G 249 THR LEU PHE ASP TYR TRP GLY GLN GLY THR LEU VAL THR SEQRES 10 G 249 VAL SER SER ALA SER THR LYS GLY PRO SER VAL PHE PRO SEQRES 11 G 249 LEU ALA PRO SER SER LYS SER THR SER GLY GLY THR ALA SEQRES 12 G 249 ALA LEU GLY CYS LEU VAL LYS ASP TYR PHE PRO GLU PRO SEQRES 13 G 249 VAL THR VAL SER TRP ASN SER GLY ALA LEU THR SER GLY SEQRES 14 G 249 VAL HIS THR PHE PRO ALA VAL LEU GLN SER SER GLY LEU SEQRES 15 G 249 TYR SER LEU SER SER VAL VAL THR VAL PRO SER SER SER SEQRES 16 G 249 LEU GLY THR GLN THR TYR ILE CYS ASN VAL ASN HIS LYS SEQRES 17 G 249 PRO SER ASN THR LYS VAL ASP LYS LYS VAL GLU PRO LYS SEQRES 18 G 249 SER CYS ALA ALA LEU VAL PRO ARG GLY SER ALA HIS HIS SEQRES 19 G 249 HIS HIS HIS HIS ALA ALA ASP TYR LYS ASP ASP ASP ASP SEQRES 20 G 249 LYS ALA SEQRES 1 I 236 LEU PHE ALA ILE PRO LEU VAL VAL PRO PHE TYR SER HIS SEQRES 2 I 236 SER ALA LEU ASP VAL VAL MET THR GLN SER PRO LEU SER SEQRES 3 I 236 LEU PRO VAL THR PRO GLY GLU PRO ALA SER ILE SER CYS SEQRES 4 I 236 ARG SER SER GLN SER LEU LEU HIS SER ASN GLY TYR ASN SEQRES 5 I 236 TYR LEU ASP TRP TYR LEU GLN LYS PRO GLY GLN SER PRO SEQRES 6 I 236 GLN LEU LEU ILE TYR LEU GLY SER ASN ARG ALA SER GLY SEQRES 7 I 236 VAL PRO ASP ARG PHE SER GLY SER GLY SER GLY THR ASP SEQRES 8 I 236 PHE THR LEU LYS ILE SER ARG VAL GLU ALA GLU ASP VAL SEQRES 9 I 236 GLY VAL TYR TYR CYS MET GLN SER LEU GLN THR PRO ARG SEQRES 10 I 236 LEU THR PHE GLY PRO GLY THR LYS VAL ASP ILE LYS ARG SEQRES 11 I 236 THR VAL ALA ALA PRO SER VAL PHE ILE PHE PRO PRO SER SEQRES 12 I 236 ASP GLU GLN LEU LYS SER GLY THR ALA SER VAL VAL CYS SEQRES 13 I 236 LEU LEU ASN ASN PHE TYR PRO ARG GLY ALA LYS VAL GLN SEQRES 14 I 236 TRP LYS VAL ASP ASN ALA LEU GLN SER GLY ASN SER GLN SEQRES 15 I 236 GLU SER VAL THR GLU GLN ASP SER LYS ASP SER THR TYR SEQRES 16 I 236 SER LEU SER SER THR LEU THR LEU SER LYS ALA ASP TYR SEQRES 17 I 236 GLU LYS HIS LYS VAL TYR ALA CYS GLU VAL THR HIS GLN SEQRES 18 I 236 GLY LEU SER SER PRO VAL THR LYS SER PHE ASN ARG GLY SEQRES 19 I 236 GLU CYS SEQRES 1 A 1683 MET ALA SER THR ASP SER GLU LYS VAL ALA GLU TYR LEU SEQRES 2 A 1683 ARG ARG ALA THR LEU ASP LEU ARG ALA ALA ARG GLN ARG SEQRES 3 A 1683 ILE ARG GLU LEU GLU GLY GLU PRO ILE ALA ILE VAL GLY SEQRES 4 A 1683 MET ALA CYS ARG LEU PRO GLY GLY VAL ALA SER PRO GLU SEQRES 5 A 1683 ASP LEU TRP ARG LEU VAL ALA GLU ARG VAL ASP ALA VAL SEQRES 6 A 1683 SER GLU PHE PRO GLY ASP ARG GLY TRP ASP LEU ASP SER SEQRES 7 A 1683 LEU ILE ASP PRO ASP ARG GLU ARG ALA GLY THR SER TYR SEQRES 8 A 1683 VAL GLY GLN GLY GLY PHE LEU HIS ASP ALA GLY GLU PHE SEQRES 9 A 1683 ASP ALA GLY PHE PHE GLY ILE SER PRO ARG GLU ALA VAL SEQRES 10 A 1683 ALA MET ASP PRO GLN GLN ARG LEU LEU LEU GLU THR SER SEQRES 11 A 1683 TRP GLU ALA LEU GLU ASN ALA GLY VAL ASP PRO ILE ALA SEQRES 12 A 1683 LEU LYS GLY THR ASP THR GLY VAL PHE SER GLY LEU MET SEQRES 13 A 1683 GLY GLN GLY TYR GLY SER GLY ALA VAL ALA PRO GLU LEU SEQRES 14 A 1683 GLU GLY PHE VAL THR THR GLY VAL ALA SER SER VAL ALA SEQRES 15 A 1683 SER GLY ARG VAL SER TYR VAL LEU GLY LEU GLU GLY PRO SEQRES 16 A 1683 ALA VAL THR VAL ASP THR ALA CYS SER SER SER LEU VAL SEQRES 17 A 1683 ALA MET HIS LEU ALA ALA GLN ALA LEU ARG GLN GLY GLU SEQRES 18 A 1683 CYS SER MET ALA LEU ALA GLY GLY VAL THR VAL MET ALA SEQRES 19 A 1683 THR PRO GLY SER PHE VAL GLU PHE SER ARG GLN ARG ALA SEQRES 20 A 1683 LEU ALA PRO ASP GLY ARG CYS LYS ALA PHE ALA ALA ALA SEQRES 21 A 1683 ALA ASP GLY THR GLY TRP SER GLU GLY VAL GLY VAL VAL SEQRES 22 A 1683 VAL LEU GLU ARG LEU SER VAL ALA ARG GLU ARG GLY HIS SEQRES 23 A 1683 ARG ILE LEU ALA VAL LEU ARG GLY SER ALA VAL ASN GLN SEQRES 24 A 1683 ASP GLY ALA SER ASN GLY LEU THR ALA PRO ASN GLY LEU SEQRES 25 A 1683 SER GLN GLN ARG VAL ILE ARG ARG ALA LEU ALA ALA ALA SEQRES 26 A 1683 GLY LEU ALA PRO SER ASP VAL ASP VAL VAL GLU ALA HIS SEQRES 27 A 1683 GLY THR GLY THR THR LEU GLY ASP PRO ILE GLU ALA GLN SEQRES 28 A 1683 ALA LEU LEU ALA THR TYR GLY GLN GLU ARG LYS GLN PRO SEQRES 29 A 1683 LEU TRP LEU GLY SER LEU LYS SER ASN ILE GLY HIS ALA SEQRES 30 A 1683 GLN ALA ALA ALA GLY VAL ALA GLY VAL ILE LYS MET VAL SEQRES 31 A 1683 GLN ALA LEU ARG HIS GLU THR LEU PRO PRO THR LEU HIS SEQRES 32 A 1683 VAL ASP LYS PRO THR LEU GLU VAL ASP TRP SER ALA GLY SEQRES 33 A 1683 ALA ILE GLU LEU LEU THR GLU ALA ARG ALA TRP PRO ARG SEQRES 34 A 1683 ASN GLY ARG PRO ARG ARG ALA GLY VAL SER SER PHE GLY SEQRES 35 A 1683 VAL SER GLY THR ASN ALA HIS LEU ILE LEU GLU GLU ALA SEQRES 36 A 1683 PRO ALA GLU GLU PRO VAL ALA ALA PRO GLU LEU PRO VAL SEQRES 37 A 1683 VAL PRO LEU VAL VAL SER ALA ARG SER THR GLU SER LEU SEQRES 38 A 1683 SER GLY GLN ALA GLU ARG LEU ALA SER LEU LEU GLU GLY SEQRES 39 A 1683 ASP VAL SER LEU THR GLU VAL ALA GLY ALA LEU VAL SER SEQRES 40 A 1683 ARG ARG ALA VAL LEU ASP GLU ARG ALA VAL VAL VAL ALA SEQRES 41 A 1683 GLY SER ARG GLU GLU ALA VAL THR GLY LEU ARG ALA LEU SEQRES 42 A 1683 ASN THR ALA GLY SER GLY THR PRO GLY LYS VAL VAL TRP SEQRES 43 A 1683 VAL PHE PRO GLY GLN GLY THR GLN TRP ALA GLY MET GLY SEQRES 44 A 1683 ARG GLU LEU LEU ALA GLU SER PRO VAL PHE ALA GLU ARG SEQRES 45 A 1683 ILE ALA GLU CYS ALA ALA ALA LEU ALA PRO TRP ILE ASP SEQRES 46 A 1683 TRP SER LEU VAL ASP VAL LEU ARG GLY GLU GLY ASP LEU SEQRES 47 A 1683 GLY ARG VAL ASP VAL LEU GLN PRO ALA CYS PHE ALA VAL SEQRES 48 A 1683 MET VAL GLY LEU ALA ALA VAL TRP GLU SER VAL GLY VAL SEQRES 49 A 1683 ARG PRO ASP ALA VAL VAL GLY HIS SER GLN GLY GLU ILE SEQRES 50 A 1683 ALA ALA ALA CYS VAL SER GLY ALA LEU SER LEU GLU ASP SEQRES 51 A 1683 ALA ALA LYS VAL VAL ALA LEU ARG SER GLN ALA ILE ALA SEQRES 52 A 1683 ALA GLU LEU SER GLY ARG GLY GLY MET ALA SER VAL ALA SEQRES 53 A 1683 LEU GLY GLU ASP ASP VAL VAL SER ARG LEU VAL ASP GLY SEQRES 54 A 1683 VAL GLU VAL ALA ALA VAL ASN GLY PRO SER SER VAL VAL SEQRES 55 A 1683 ILE ALA GLY ASP ALA HIS ALA LEU ASP ALA THR LEU GLU SEQRES 56 A 1683 ILE LEU SER GLY GLU GLY ILE ARG VAL ARG ARG VAL ALA SEQRES 57 A 1683 VAL ASP TYR ALA SER HIS THR ARG HIS VAL GLU ASP ILE SEQRES 58 A 1683 ARG ASP THR LEU ALA GLU THR LEU ALA GLY ILE SER ALA SEQRES 59 A 1683 GLN ALA PRO ALA VAL PRO PHE TYR SER THR VAL THR SER SEQRES 60 A 1683 GLU TRP VAL ARG ASP ALA GLY VAL LEU ASP GLY GLY TYR SEQRES 61 A 1683 TRP TYR ARG ASN LEU ARG ASN GLN VAL ARG PHE GLY ALA SEQRES 62 A 1683 ALA ALA THR ALA LEU LEU GLU GLN GLY HIS THR VAL PHE SEQRES 63 A 1683 VAL GLU VAL SER ALA HIS PRO VAL THR VAL GLN PRO LEU SEQRES 64 A 1683 SER GLU LEU THR GLY ASP ALA ILE GLY THR LEU ARG ARG SEQRES 65 A 1683 GLU ASP GLY GLY LEU ARG ARG LEU LEU ALA SER MET GLY SEQRES 66 A 1683 GLU LEU PHE VAL ARG GLY ILE ASP VAL ASP TRP THR ALA SEQRES 67 A 1683 MET VAL PRO ALA ALA GLY TRP VAL ASP LEU PRO THR TYR SEQRES 68 A 1683 ALA PHE GLU HIS ARG HIS TYR TRP LEU GLU PRO ALA GLU SEQRES 69 A 1683 PRO ALA SER ALA GLY ASP PRO LEU LEU GLY THR VAL VAL SEQRES 70 A 1683 SER THR PRO GLY SER ASP ARG LEU THR ALA VAL ALA GLN SEQRES 71 A 1683 TRP SER ARG ARG ALA GLN PRO TRP ALA VAL ASP GLY LEU SEQRES 72 A 1683 VAL PRO ASN ALA ALA LEU VAL GLU ALA ALA ILE ARG LEU SEQRES 73 A 1683 GLY ASP LEU ALA GLY THR PRO VAL VAL GLY GLU LEU VAL SEQRES 74 A 1683 VAL ASP ALA PRO VAL VAL LEU PRO ARG ARG GLY SER ARG SEQRES 75 A 1683 GLU VAL GLN LEU ILE VAL GLY GLU PRO GLY GLU GLN ARG SEQRES 76 A 1683 ARG ARG PRO ILE GLU VAL PHE SER ARG GLU ALA ASP GLU SEQRES 77 A 1683 PRO TRP THR ARG HIS ALA HIS GLY THR LEU ALA PRO ALA SEQRES 78 A 1683 ALA ALA ALA VAL PRO GLU PRO ALA ALA ALA GLY ASP ALA SEQRES 79 A 1683 THR ASP VAL THR VAL ALA GLY LEU ARG ASP ALA ASP ARG SEQRES 80 A 1683 TYR GLY ILE HIS PRO ALA LEU LEU ASP ALA ALA VAL ARG SEQRES 81 A 1683 THR VAL VAL GLY ASP ASP LEU LEU PRO SER VAL TRP THR SEQRES 82 A 1683 GLY VAL SER LEU LEU ALA SER GLY ALA THR ALA VAL THR SEQRES 83 A 1683 VAL THR PRO THR ALA THR GLY LEU ARG LEU THR ASP PRO SEQRES 84 A 1683 ALA GLY GLN PRO VAL LEU THR VAL GLU SER VAL ARG GLY SEQRES 85 A 1683 THR PRO PHE VAL ALA GLU GLN GLY THR THR ASP ALA LEU SEQRES 86 A 1683 PHE ARG VAL ASP TRP PRO GLU ILE PRO LEU PRO THR ALA SEQRES 87 A 1683 GLU THR ALA ASP PHE LEU PRO TYR GLU ALA THR SER ALA SEQRES 88 A 1683 GLU ALA THR LEU SER ALA LEU GLN ALA TRP LEU ALA ASP SEQRES 89 A 1683 PRO ALA GLU THR ARG LEU ALA VAL VAL THR GLY ASP CYS SEQRES 90 A 1683 THR GLU PRO GLY ALA ALA ALA ILE TRP GLY LEU VAL ARG SEQRES 91 A 1683 SER ALA GLN SER GLU HIS PRO GLY ARG ILE VAL LEU ALA SEQRES 92 A 1683 ASP LEU ASP ASP PRO ALA VAL LEU PRO ALA VAL VAL ALA SEQRES 93 A 1683 SER GLY GLU PRO GLN VAL ARG VAL ARG ASN GLY VAL ALA SEQRES 94 A 1683 SER VAL PRO ARG LEU THR ARG VAL THR PRO ARG GLN ASP SEQRES 95 A 1683 ALA ARG PRO LEU ASP PRO GLU GLY THR VAL LEU ILE THR SEQRES 96 A 1683 GLY GLY THR GLY THR LEU GLY ALA LEU THR ALA ARG HIS SEQRES 97 A 1683 LEU VAL THR ALA HIS GLY VAL ARG HIS LEU VAL LEU VAL SEQRES 98 A 1683 SER ARG ARG GLY GLU ALA PRO GLU LEU GLN GLU GLU LEU SEQRES 99 A 1683 THR ALA LEU GLY ALA SER VAL ALA ILE ALA ALA CYS ASP SEQRES 100 A 1683 VAL ALA ASP ARG ALA GLN LEU GLU ALA VAL LEU ARG ALA SEQRES 101 A 1683 ILE PRO ALA GLU HIS PRO LEU THR ALA VAL ILE HIS THR SEQRES 102 A 1683 ALA GLY VAL LEU ASP ASP GLY VAL VAL THR GLU LEU THR SEQRES 103 A 1683 PRO ASP ARG LEU ALA THR VAL ARG ARG PRO LYS VAL ASP SEQRES 104 A 1683 ALA ALA ARG LEU LEU ASP GLU LEU THR ARG GLU ALA ASP SEQRES 105 A 1683 LEU ALA ALA PHE VAL LEU PHE SER SER ALA ALA GLY VAL SEQRES 106 A 1683 LEU GLY ASN PRO GLY GLN ALA GLY TYR ALA ALA ALA ASN SEQRES 107 A 1683 ALA GLU LEU ASP ALA LEU ALA ARG GLN ARG ASN SER LEU SEQRES 108 A 1683 ASP LEU PRO ALA VAL SER ILE ALA TRP GLY TYR TRP ALA SEQRES 109 A 1683 THR VAL SER GLY MET THR GLU HIS LEU GLY ASP ALA ASP SEQRES 110 A 1683 LEU ARG ARG ASN GLN ARG ILE GLY MET SER GLY LEU PRO SEQRES 111 A 1683 ALA ASP GLU GLY MET ALA LEU LEU ASP ALA ALA ILE ALA SEQRES 112 A 1683 THR GLY GLY THR LEU VAL ALA ALA LYS PHE ASP VAL ALA SEQRES 113 A 1683 ALA LEU ARG ALA THR ALA LYS ALA GLY GLY PRO VAL PRO SEQRES 114 A 1683 PRO LEU LEU ARG GLY LEU ALA PRO LEU PRO ARG ARG ALA SEQRES 115 A 1683 ALA ALA LYS THR ALA SER LEU THR GLU ARG LEU ALA GLY SEQRES 116 A 1683 LEU ALA GLU THR GLU GLN ALA ALA ALA LEU LEU ASP LEU SEQRES 117 A 1683 VAL ARG ARG HIS ALA ALA GLU VAL LEU GLY HIS SER GLY SEQRES 118 A 1683 ALA GLU SER VAL HIS SER GLY ARG THR PHE LYS ASP ALA SEQRES 119 A 1683 GLY PHE ASP SER LEU THR ALA VAL GLU LEU ARG ASN ARG SEQRES 120 A 1683 LEU ALA ALA ALA THR GLY LEU THR LEU SER PRO ALA MET SEQRES 121 A 1683 ILE PHE ASP TYR PRO LYS PRO PRO ALA LEU ALA ASP HIS SEQRES 122 A 1683 LEU ARG ALA LYS LEU PHE GLY THR GLU VAL ARG GLY GLU SEQRES 123 A 1683 ALA PRO SER ALA LEU ALA GLY LEU ASP ALA LEU GLU ALA SEQRES 124 A 1683 ALA LEU PRO GLU VAL PRO ALA THR GLU ARG GLU GLU LEU SEQRES 125 A 1683 VAL GLN ARG LEU GLU ARG MET LEU ALA ALA LEU ARG PRO SEQRES 126 A 1683 VAL ALA GLN ALA ALA ASP ALA SER GLY THR GLY ALA ASN SEQRES 127 A 1683 PRO SER GLY ASP ASP LEU GLY GLU ALA GLY VAL ASP GLU SEQRES 128 A 1683 LEU LEU GLU ALA LEU GLY ARG GLU LEU ASP GLY ASP GLY SEQRES 129 A 1683 ASN SER SER SER VAL ASP LYS LEU ALA ALA ALA LEU GLU SEQRES 130 A 1683 HIS HIS HIS HIS HIS HIS SEQRES 1 B 1683 MET ALA SER THR ASP SER GLU LYS VAL ALA GLU TYR LEU SEQRES 2 B 1683 ARG ARG ALA THR LEU ASP LEU ARG ALA ALA ARG GLN ARG SEQRES 3 B 1683 ILE ARG GLU LEU GLU GLY GLU PRO ILE ALA ILE VAL GLY SEQRES 4 B 1683 MET ALA CYS ARG LEU PRO GLY GLY VAL ALA SER PRO GLU SEQRES 5 B 1683 ASP LEU TRP ARG LEU VAL ALA GLU ARG VAL ASP ALA VAL SEQRES 6 B 1683 SER GLU PHE PRO GLY ASP ARG GLY TRP ASP LEU ASP SER SEQRES 7 B 1683 LEU ILE ASP PRO ASP ARG GLU ARG ALA GLY THR SER TYR SEQRES 8 B 1683 VAL GLY GLN GLY GLY PHE LEU HIS ASP ALA GLY GLU PHE SEQRES 9 B 1683 ASP ALA GLY PHE PHE GLY ILE SER PRO ARG GLU ALA VAL SEQRES 10 B 1683 ALA MET ASP PRO GLN GLN ARG LEU LEU LEU GLU THR SER SEQRES 11 B 1683 TRP GLU ALA LEU GLU ASN ALA GLY VAL ASP PRO ILE ALA SEQRES 12 B 1683 LEU LYS GLY THR ASP THR GLY VAL PHE SER GLY LEU MET SEQRES 13 B 1683 GLY GLN GLY TYR GLY SER GLY ALA VAL ALA PRO GLU LEU SEQRES 14 B 1683 GLU GLY PHE VAL THR THR GLY VAL ALA SER SER VAL ALA SEQRES 15 B 1683 SER GLY ARG VAL SER TYR VAL LEU GLY LEU GLU GLY PRO SEQRES 16 B 1683 ALA VAL THR VAL ASP THR ALA CYS SER SER SER LEU VAL SEQRES 17 B 1683 ALA MET HIS LEU ALA ALA GLN ALA LEU ARG GLN GLY GLU SEQRES 18 B 1683 CYS SER MET ALA LEU ALA GLY GLY VAL THR VAL MET ALA SEQRES 19 B 1683 THR PRO GLY SER PHE VAL GLU PHE SER ARG GLN ARG ALA SEQRES 20 B 1683 LEU ALA PRO ASP GLY ARG CYS LYS ALA PHE ALA ALA ALA SEQRES 21 B 1683 ALA ASP GLY THR GLY TRP SER GLU GLY VAL GLY VAL VAL SEQRES 22 B 1683 VAL LEU GLU ARG LEU SER VAL ALA ARG GLU ARG GLY HIS SEQRES 23 B 1683 ARG ILE LEU ALA VAL LEU ARG GLY SER ALA VAL ASN GLN SEQRES 24 B 1683 ASP GLY ALA SER ASN GLY LEU THR ALA PRO ASN GLY LEU SEQRES 25 B 1683 SER GLN GLN ARG VAL ILE ARG ARG ALA LEU ALA ALA ALA SEQRES 26 B 1683 GLY LEU ALA PRO SER ASP VAL ASP VAL VAL GLU ALA HIS SEQRES 27 B 1683 GLY THR GLY THR THR LEU GLY ASP PRO ILE GLU ALA GLN SEQRES 28 B 1683 ALA LEU LEU ALA THR TYR GLY GLN GLU ARG LYS GLN PRO SEQRES 29 B 1683 LEU TRP LEU GLY SER LEU LYS SER ASN ILE GLY HIS ALA SEQRES 30 B 1683 GLN ALA ALA ALA GLY VAL ALA GLY VAL ILE LYS MET VAL SEQRES 31 B 1683 GLN ALA LEU ARG HIS GLU THR LEU PRO PRO THR LEU HIS SEQRES 32 B 1683 VAL ASP LYS PRO THR LEU GLU VAL ASP TRP SER ALA GLY SEQRES 33 B 1683 ALA ILE GLU LEU LEU THR GLU ALA ARG ALA TRP PRO ARG SEQRES 34 B 1683 ASN GLY ARG PRO ARG ARG ALA GLY VAL SER SER PHE GLY SEQRES 35 B 1683 VAL SER GLY THR ASN ALA HIS LEU ILE LEU GLU GLU ALA SEQRES 36 B 1683 PRO ALA GLU GLU PRO VAL ALA ALA PRO GLU LEU PRO VAL SEQRES 37 B 1683 VAL PRO LEU VAL VAL SER ALA ARG SER THR GLU SER LEU SEQRES 38 B 1683 SER GLY GLN ALA GLU ARG LEU ALA SER LEU LEU GLU GLY SEQRES 39 B 1683 ASP VAL SER LEU THR GLU VAL ALA GLY ALA LEU VAL SER SEQRES 40 B 1683 ARG ARG ALA VAL LEU ASP GLU ARG ALA VAL VAL VAL ALA SEQRES 41 B 1683 GLY SER ARG GLU GLU ALA VAL THR GLY LEU ARG ALA LEU SEQRES 42 B 1683 ASN THR ALA GLY SER GLY THR PRO GLY LYS VAL VAL TRP SEQRES 43 B 1683 VAL PHE PRO GLY GLN GLY THR GLN TRP ALA GLY MET GLY SEQRES 44 B 1683 ARG GLU LEU LEU ALA GLU SER PRO VAL PHE ALA GLU ARG SEQRES 45 B 1683 ILE ALA GLU CYS ALA ALA ALA LEU ALA PRO TRP ILE ASP SEQRES 46 B 1683 TRP SER LEU VAL ASP VAL LEU ARG GLY GLU GLY ASP LEU SEQRES 47 B 1683 GLY ARG VAL ASP VAL LEU GLN PRO ALA CYS PHE ALA VAL SEQRES 48 B 1683 MET VAL GLY LEU ALA ALA VAL TRP GLU SER VAL GLY VAL SEQRES 49 B 1683 ARG PRO ASP ALA VAL VAL GLY HIS SER GLN GLY GLU ILE SEQRES 50 B 1683 ALA ALA ALA CYS VAL SER GLY ALA LEU SER LEU GLU ASP SEQRES 51 B 1683 ALA ALA LYS VAL VAL ALA LEU ARG SER GLN ALA ILE ALA SEQRES 52 B 1683 ALA GLU LEU SER GLY ARG GLY GLY MET ALA SER VAL ALA SEQRES 53 B 1683 LEU GLY GLU ASP ASP VAL VAL SER ARG LEU VAL ASP GLY SEQRES 54 B 1683 VAL GLU VAL ALA ALA VAL ASN GLY PRO SER SER VAL VAL SEQRES 55 B 1683 ILE ALA GLY ASP ALA HIS ALA LEU ASP ALA THR LEU GLU SEQRES 56 B 1683 ILE LEU SER GLY GLU GLY ILE ARG VAL ARG ARG VAL ALA SEQRES 57 B 1683 VAL ASP TYR ALA SER HIS THR ARG HIS VAL GLU ASP ILE SEQRES 58 B 1683 ARG ASP THR LEU ALA GLU THR LEU ALA GLY ILE SER ALA SEQRES 59 B 1683 GLN ALA PRO ALA VAL PRO PHE TYR SER THR VAL THR SER SEQRES 60 B 1683 GLU TRP VAL ARG ASP ALA GLY VAL LEU ASP GLY GLY TYR SEQRES 61 B 1683 TRP TYR ARG ASN LEU ARG ASN GLN VAL ARG PHE GLY ALA SEQRES 62 B 1683 ALA ALA THR ALA LEU LEU GLU GLN GLY HIS THR VAL PHE SEQRES 63 B 1683 VAL GLU VAL SER ALA HIS PRO VAL THR VAL GLN PRO LEU SEQRES 64 B 1683 SER GLU LEU THR GLY ASP ALA ILE GLY THR LEU ARG ARG SEQRES 65 B 1683 GLU ASP GLY GLY LEU ARG ARG LEU LEU ALA SER MET GLY SEQRES 66 B 1683 GLU LEU PHE VAL ARG GLY ILE ASP VAL ASP TRP THR ALA SEQRES 67 B 1683 MET VAL PRO ALA ALA GLY TRP VAL ASP LEU PRO THR TYR SEQRES 68 B 1683 ALA PHE GLU HIS ARG HIS TYR TRP LEU GLU PRO ALA GLU SEQRES 69 B 1683 PRO ALA SER ALA GLY ASP PRO LEU LEU GLY THR VAL VAL SEQRES 70 B 1683 SER THR PRO GLY SER ASP ARG LEU THR ALA VAL ALA GLN SEQRES 71 B 1683 TRP SER ARG ARG ALA GLN PRO TRP ALA VAL ASP GLY LEU SEQRES 72 B 1683 VAL PRO ASN ALA ALA LEU VAL GLU ALA ALA ILE ARG LEU SEQRES 73 B 1683 GLY ASP LEU ALA GLY THR PRO VAL VAL GLY GLU LEU VAL SEQRES 74 B 1683 VAL ASP ALA PRO VAL VAL LEU PRO ARG ARG GLY SER ARG SEQRES 75 B 1683 GLU VAL GLN LEU ILE VAL GLY GLU PRO GLY GLU GLN ARG SEQRES 76 B 1683 ARG ARG PRO ILE GLU VAL PHE SER ARG GLU ALA ASP GLU SEQRES 77 B 1683 PRO TRP THR ARG HIS ALA HIS GLY THR LEU ALA PRO ALA SEQRES 78 B 1683 ALA ALA ALA VAL PRO GLU PRO ALA ALA ALA GLY ASP ALA SEQRES 79 B 1683 THR ASP VAL THR VAL ALA GLY LEU ARG ASP ALA ASP ARG SEQRES 80 B 1683 TYR GLY ILE HIS PRO ALA LEU LEU ASP ALA ALA VAL ARG SEQRES 81 B 1683 THR VAL VAL GLY ASP ASP LEU LEU PRO SER VAL TRP THR SEQRES 82 B 1683 GLY VAL SER LEU LEU ALA SER GLY ALA THR ALA VAL THR SEQRES 83 B 1683 VAL THR PRO THR ALA THR GLY LEU ARG LEU THR ASP PRO SEQRES 84 B 1683 ALA GLY GLN PRO VAL LEU THR VAL GLU SER VAL ARG GLY SEQRES 85 B 1683 THR PRO PHE VAL ALA GLU GLN GLY THR THR ASP ALA LEU SEQRES 86 B 1683 PHE ARG VAL ASP TRP PRO GLU ILE PRO LEU PRO THR ALA SEQRES 87 B 1683 GLU THR ALA ASP PHE LEU PRO TYR GLU ALA THR SER ALA SEQRES 88 B 1683 GLU ALA THR LEU SER ALA LEU GLN ALA TRP LEU ALA ASP SEQRES 89 B 1683 PRO ALA GLU THR ARG LEU ALA VAL VAL THR GLY ASP CYS SEQRES 90 B 1683 THR GLU PRO GLY ALA ALA ALA ILE TRP GLY LEU VAL ARG SEQRES 91 B 1683 SER ALA GLN SER GLU HIS PRO GLY ARG ILE VAL LEU ALA SEQRES 92 B 1683 ASP LEU ASP ASP PRO ALA VAL LEU PRO ALA VAL VAL ALA SEQRES 93 B 1683 SER GLY GLU PRO GLN VAL ARG VAL ARG ASN GLY VAL ALA SEQRES 94 B 1683 SER VAL PRO ARG LEU THR ARG VAL THR PRO ARG GLN ASP SEQRES 95 B 1683 ALA ARG PRO LEU ASP PRO GLU GLY THR VAL LEU ILE THR SEQRES 96 B 1683 GLY GLY THR GLY THR LEU GLY ALA LEU THR ALA ARG HIS SEQRES 97 B 1683 LEU VAL THR ALA HIS GLY VAL ARG HIS LEU VAL LEU VAL SEQRES 98 B 1683 SER ARG ARG GLY GLU ALA PRO GLU LEU GLN GLU GLU LEU SEQRES 99 B 1683 THR ALA LEU GLY ALA SER VAL ALA ILE ALA ALA CYS ASP SEQRES 100 B 1683 VAL ALA ASP ARG ALA GLN LEU GLU ALA VAL LEU ARG ALA SEQRES 101 B 1683 ILE PRO ALA GLU HIS PRO LEU THR ALA VAL ILE HIS THR SEQRES 102 B 1683 ALA GLY VAL LEU ASP ASP GLY VAL VAL THR GLU LEU THR SEQRES 103 B 1683 PRO ASP ARG LEU ALA THR VAL ARG ARG PRO LYS VAL ASP SEQRES 104 B 1683 ALA ALA ARG LEU LEU ASP GLU LEU THR ARG GLU ALA ASP SEQRES 105 B 1683 LEU ALA ALA PHE VAL LEU PHE SER SER ALA ALA GLY VAL SEQRES 106 B 1683 LEU GLY ASN PRO GLY GLN ALA GLY TYR ALA ALA ALA ASN SEQRES 107 B 1683 ALA GLU LEU ASP ALA LEU ALA ARG GLN ARG ASN SER LEU SEQRES 108 B 1683 ASP LEU PRO ALA VAL SER ILE ALA TRP GLY TYR TRP ALA SEQRES 109 B 1683 THR VAL SER GLY MET THR GLU HIS LEU GLY ASP ALA ASP SEQRES 110 B 1683 LEU ARG ARG ASN GLN ARG ILE GLY MET SER GLY LEU PRO SEQRES 111 B 1683 ALA ASP GLU GLY MET ALA LEU LEU ASP ALA ALA ILE ALA SEQRES 112 B 1683 THR GLY GLY THR LEU VAL ALA ALA LYS PHE ASP VAL ALA SEQRES 113 B 1683 ALA LEU ARG ALA THR ALA LYS ALA GLY GLY PRO VAL PRO SEQRES 114 B 1683 PRO LEU LEU ARG GLY LEU ALA PRO LEU PRO ARG ARG ALA SEQRES 115 B 1683 ALA ALA LYS THR ALA SER LEU THR GLU ARG LEU ALA GLY SEQRES 116 B 1683 LEU ALA GLU THR GLU GLN ALA ALA ALA LEU LEU ASP LEU SEQRES 117 B 1683 VAL ARG ARG HIS ALA ALA GLU VAL LEU GLY HIS SER GLY SEQRES 118 B 1683 ALA GLU SER VAL HIS SER GLY ARG THR PHE LYS ASP ALA SEQRES 119 B 1683 GLY PHE ASP SER LEU THR ALA VAL GLU LEU ARG ASN ARG SEQRES 120 B 1683 LEU ALA ALA ALA THR GLY LEU THR LEU SER PRO ALA MET SEQRES 121 B 1683 ILE PHE ASP TYR PRO LYS PRO PRO ALA LEU ALA ASP HIS SEQRES 122 B 1683 LEU ARG ALA LYS LEU PHE GLY THR GLU VAL ARG GLY GLU SEQRES 123 B 1683 ALA PRO SER ALA LEU ALA GLY LEU ASP ALA LEU GLU ALA SEQRES 124 B 1683 ALA LEU PRO GLU VAL PRO ALA THR GLU ARG GLU GLU LEU SEQRES 125 B 1683 VAL GLN ARG LEU GLU ARG MET LEU ALA ALA LEU ARG PRO SEQRES 126 B 1683 VAL ALA GLN ALA ALA ASP ALA SER GLY THR GLY ALA ASN SEQRES 127 B 1683 PRO SER GLY ASP ASP LEU GLY GLU ALA GLY VAL ASP GLU SEQRES 128 B 1683 LEU LEU GLU ALA LEU GLY ARG GLU LEU ASP GLY ASP GLY SEQRES 129 B 1683 ASN SER SER SER VAL ASP LYS LEU ALA ALA ALA LEU GLU SEQRES 130 B 1683 HIS HIS HIS HIS HIS HIS SEQRES 1 C 1683 MET ALA SER THR ASP SER GLU LYS VAL ALA GLU TYR LEU SEQRES 2 C 1683 ARG ARG ALA THR LEU ASP LEU ARG ALA ALA ARG GLN ARG SEQRES 3 C 1683 ILE ARG GLU LEU GLU GLY GLU PRO ILE ALA ILE VAL GLY SEQRES 4 C 1683 MET ALA CYS ARG LEU PRO GLY GLY VAL ALA SER PRO GLU SEQRES 5 C 1683 ASP LEU TRP ARG LEU VAL ALA GLU ARG VAL ASP ALA VAL SEQRES 6 C 1683 SER GLU PHE PRO GLY ASP ARG GLY TRP ASP LEU ASP SER SEQRES 7 C 1683 LEU ILE ASP PRO ASP ARG GLU ARG ALA GLY THR SER TYR SEQRES 8 C 1683 VAL GLY GLN GLY GLY PHE LEU HIS ASP ALA GLY GLU PHE SEQRES 9 C 1683 ASP ALA GLY PHE PHE GLY ILE SER PRO ARG GLU ALA VAL SEQRES 10 C 1683 ALA MET ASP PRO GLN GLN ARG LEU LEU LEU GLU THR SER SEQRES 11 C 1683 TRP GLU ALA LEU GLU ASN ALA GLY VAL ASP PRO ILE ALA SEQRES 12 C 1683 LEU LYS GLY THR ASP THR GLY VAL PHE SER GLY LEU MET SEQRES 13 C 1683 GLY GLN GLY TYR GLY SER GLY ALA VAL ALA PRO GLU LEU SEQRES 14 C 1683 GLU GLY PHE VAL THR THR GLY VAL ALA SER SER VAL ALA SEQRES 15 C 1683 SER GLY ARG VAL SER TYR VAL LEU GLY LEU GLU GLY PRO SEQRES 16 C 1683 ALA VAL THR VAL ASP THR ALA CYS SER SER SER LEU VAL SEQRES 17 C 1683 ALA MET HIS LEU ALA ALA GLN ALA LEU ARG GLN GLY GLU SEQRES 18 C 1683 CYS SER MET ALA LEU ALA GLY GLY VAL THR VAL MET ALA SEQRES 19 C 1683 THR PRO GLY SER PHE VAL GLU PHE SER ARG GLN ARG ALA SEQRES 20 C 1683 LEU ALA PRO ASP GLY ARG CYS LYS ALA PHE ALA ALA ALA SEQRES 21 C 1683 ALA ASP GLY THR GLY TRP SER GLU GLY VAL GLY VAL VAL SEQRES 22 C 1683 VAL LEU GLU ARG LEU SER VAL ALA ARG GLU ARG GLY HIS SEQRES 23 C 1683 ARG ILE LEU ALA VAL LEU ARG GLY SER ALA VAL ASN GLN SEQRES 24 C 1683 ASP GLY ALA SER ASN GLY LEU THR ALA PRO ASN GLY LEU SEQRES 25 C 1683 SER GLN GLN ARG VAL ILE ARG ARG ALA LEU ALA ALA ALA SEQRES 26 C 1683 GLY LEU ALA PRO SER ASP VAL ASP VAL VAL GLU ALA HIS SEQRES 27 C 1683 GLY THR GLY THR THR LEU GLY ASP PRO ILE GLU ALA GLN SEQRES 28 C 1683 ALA LEU LEU ALA THR TYR GLY GLN GLU ARG LYS GLN PRO SEQRES 29 C 1683 LEU TRP LEU GLY SER LEU LYS SER ASN ILE GLY HIS ALA SEQRES 30 C 1683 GLN ALA ALA ALA GLY VAL ALA GLY VAL ILE LYS MET VAL SEQRES 31 C 1683 GLN ALA LEU ARG HIS GLU THR LEU PRO PRO THR LEU HIS SEQRES 32 C 1683 VAL ASP LYS PRO THR LEU GLU VAL ASP TRP SER ALA GLY SEQRES 33 C 1683 ALA ILE GLU LEU LEU THR GLU ALA ARG ALA TRP PRO ARG SEQRES 34 C 1683 ASN GLY ARG PRO ARG ARG ALA GLY VAL SER SER PHE GLY SEQRES 35 C 1683 VAL SER GLY THR ASN ALA HIS LEU ILE LEU GLU GLU ALA SEQRES 36 C 1683 PRO ALA GLU GLU PRO VAL ALA ALA PRO GLU LEU PRO VAL SEQRES 37 C 1683 VAL PRO LEU VAL VAL SER ALA ARG SER THR GLU SER LEU SEQRES 38 C 1683 SER GLY GLN ALA GLU ARG LEU ALA SER LEU LEU GLU GLY SEQRES 39 C 1683 ASP VAL SER LEU THR GLU VAL ALA GLY ALA LEU VAL SER SEQRES 40 C 1683 ARG ARG ALA VAL LEU ASP GLU ARG ALA VAL VAL VAL ALA SEQRES 41 C 1683 GLY SER ARG GLU GLU ALA VAL THR GLY LEU ARG ALA LEU SEQRES 42 C 1683 ASN THR ALA GLY SER GLY THR PRO GLY LYS VAL VAL TRP SEQRES 43 C 1683 VAL PHE PRO GLY GLN GLY THR GLN TRP ALA GLY MET GLY SEQRES 44 C 1683 ARG GLU LEU LEU ALA GLU SER PRO VAL PHE ALA GLU ARG SEQRES 45 C 1683 ILE ALA GLU CYS ALA ALA ALA LEU ALA PRO TRP ILE ASP SEQRES 46 C 1683 TRP SER LEU VAL ASP VAL LEU ARG GLY GLU GLY ASP LEU SEQRES 47 C 1683 GLY ARG VAL ASP VAL LEU GLN PRO ALA CYS PHE ALA VAL SEQRES 48 C 1683 MET VAL GLY LEU ALA ALA VAL TRP GLU SER VAL GLY VAL SEQRES 49 C 1683 ARG PRO ASP ALA VAL VAL GLY HIS SER GLN GLY GLU ILE SEQRES 50 C 1683 ALA ALA ALA CYS VAL SER GLY ALA LEU SER LEU GLU ASP SEQRES 51 C 1683 ALA ALA LYS VAL VAL ALA LEU ARG SER GLN ALA ILE ALA SEQRES 52 C 1683 ALA GLU LEU SER GLY ARG GLY GLY MET ALA SER VAL ALA SEQRES 53 C 1683 LEU GLY GLU ASP ASP VAL VAL SER ARG LEU VAL ASP GLY SEQRES 54 C 1683 VAL GLU VAL ALA ALA VAL ASN GLY PRO SER SER VAL VAL SEQRES 55 C 1683 ILE ALA GLY ASP ALA HIS ALA LEU ASP ALA THR LEU GLU SEQRES 56 C 1683 ILE LEU SER GLY GLU GLY ILE ARG VAL ARG ARG VAL ALA SEQRES 57 C 1683 VAL ASP TYR ALA SER HIS THR ARG HIS VAL GLU ASP ILE SEQRES 58 C 1683 ARG ASP THR LEU ALA GLU THR LEU ALA GLY ILE SER ALA SEQRES 59 C 1683 GLN ALA PRO ALA VAL PRO PHE TYR SER THR VAL THR SER SEQRES 60 C 1683 GLU TRP VAL ARG ASP ALA GLY VAL LEU ASP GLY GLY TYR SEQRES 61 C 1683 TRP TYR ARG ASN LEU ARG ASN GLN VAL ARG PHE GLY ALA SEQRES 62 C 1683 ALA ALA THR ALA LEU LEU GLU GLN GLY HIS THR VAL PHE SEQRES 63 C 1683 VAL GLU VAL SER ALA HIS PRO VAL THR VAL GLN PRO LEU SEQRES 64 C 1683 SER GLU LEU THR GLY ASP ALA ILE GLY THR LEU ARG ARG SEQRES 65 C 1683 GLU ASP GLY GLY LEU ARG ARG LEU LEU ALA SER MET GLY SEQRES 66 C 1683 GLU LEU PHE VAL ARG GLY ILE ASP VAL ASP TRP THR ALA SEQRES 67 C 1683 MET VAL PRO ALA ALA GLY TRP VAL ASP LEU PRO THR TYR SEQRES 68 C 1683 ALA PHE GLU HIS ARG HIS TYR TRP LEU GLU PRO ALA GLU SEQRES 69 C 1683 PRO ALA SER ALA GLY ASP PRO LEU LEU GLY THR VAL VAL SEQRES 70 C 1683 SER THR PRO GLY SER ASP ARG LEU THR ALA VAL ALA GLN SEQRES 71 C 1683 TRP SER ARG ARG ALA GLN PRO TRP ALA VAL ASP GLY LEU SEQRES 72 C 1683 VAL PRO ASN ALA ALA LEU VAL GLU ALA ALA ILE ARG LEU SEQRES 73 C 1683 GLY ASP LEU ALA GLY THR PRO VAL VAL GLY GLU LEU VAL SEQRES 74 C 1683 VAL ASP ALA PRO VAL VAL LEU PRO ARG ARG GLY SER ARG SEQRES 75 C 1683 GLU VAL GLN LEU ILE VAL GLY GLU PRO GLY GLU GLN ARG SEQRES 76 C 1683 ARG ARG PRO ILE GLU VAL PHE SER ARG GLU ALA ASP GLU SEQRES 77 C 1683 PRO TRP THR ARG HIS ALA HIS GLY THR LEU ALA PRO ALA SEQRES 78 C 1683 ALA ALA ALA VAL PRO GLU PRO ALA ALA ALA GLY ASP ALA SEQRES 79 C 1683 THR ASP VAL THR VAL ALA GLY LEU ARG ASP ALA ASP ARG SEQRES 80 C 1683 TYR GLY ILE HIS PRO ALA LEU LEU ASP ALA ALA VAL ARG SEQRES 81 C 1683 THR VAL VAL GLY ASP ASP LEU LEU PRO SER VAL TRP THR SEQRES 82 C 1683 GLY VAL SER LEU LEU ALA SER GLY ALA THR ALA VAL THR SEQRES 83 C 1683 VAL THR PRO THR ALA THR GLY LEU ARG LEU THR ASP PRO SEQRES 84 C 1683 ALA GLY GLN PRO VAL LEU THR VAL GLU SER VAL ARG GLY SEQRES 85 C 1683 THR PRO PHE VAL ALA GLU GLN GLY THR THR ASP ALA LEU SEQRES 86 C 1683 PHE ARG VAL ASP TRP PRO GLU ILE PRO LEU PRO THR ALA SEQRES 87 C 1683 GLU THR ALA ASP PHE LEU PRO TYR GLU ALA THR SER ALA SEQRES 88 C 1683 GLU ALA THR LEU SER ALA LEU GLN ALA TRP LEU ALA ASP SEQRES 89 C 1683 PRO ALA GLU THR ARG LEU ALA VAL VAL THR GLY ASP CYS SEQRES 90 C 1683 THR GLU PRO GLY ALA ALA ALA ILE TRP GLY LEU VAL ARG SEQRES 91 C 1683 SER ALA GLN SER GLU HIS PRO GLY ARG ILE VAL LEU ALA SEQRES 92 C 1683 ASP LEU ASP ASP PRO ALA VAL LEU PRO ALA VAL VAL ALA SEQRES 93 C 1683 SER GLY GLU PRO GLN VAL ARG VAL ARG ASN GLY VAL ALA SEQRES 94 C 1683 SER VAL PRO ARG LEU THR ARG VAL THR PRO ARG GLN ASP SEQRES 95 C 1683 ALA ARG PRO LEU ASP PRO GLU GLY THR VAL LEU ILE THR SEQRES 96 C 1683 GLY GLY THR GLY THR LEU GLY ALA LEU THR ALA ARG HIS SEQRES 97 C 1683 LEU VAL THR ALA HIS GLY VAL ARG HIS LEU VAL LEU VAL SEQRES 98 C 1683 SER ARG ARG GLY GLU ALA PRO GLU LEU GLN GLU GLU LEU SEQRES 99 C 1683 THR ALA LEU GLY ALA SER VAL ALA ILE ALA ALA CYS ASP SEQRES 100 C 1683 VAL ALA ASP ARG ALA GLN LEU GLU ALA VAL LEU ARG ALA SEQRES 101 C 1683 ILE PRO ALA GLU HIS PRO LEU THR ALA VAL ILE HIS THR SEQRES 102 C 1683 ALA GLY VAL LEU ASP ASP GLY VAL VAL THR GLU LEU THR SEQRES 103 C 1683 PRO ASP ARG LEU ALA THR VAL ARG ARG PRO LYS VAL ASP SEQRES 104 C 1683 ALA ALA ARG LEU LEU ASP GLU LEU THR ARG GLU ALA ASP SEQRES 105 C 1683 LEU ALA ALA PHE VAL LEU PHE SER SER ALA ALA GLY VAL SEQRES 106 C 1683 LEU GLY ASN PRO GLY GLN ALA GLY TYR ALA ALA ALA ASN SEQRES 107 C 1683 ALA GLU LEU ASP ALA LEU ALA ARG GLN ARG ASN SER LEU SEQRES 108 C 1683 ASP LEU PRO ALA VAL SER ILE ALA TRP GLY TYR TRP ALA SEQRES 109 C 1683 THR VAL SER GLY MET THR GLU HIS LEU GLY ASP ALA ASP SEQRES 110 C 1683 LEU ARG ARG ASN GLN ARG ILE GLY MET SER GLY LEU PRO SEQRES 111 C 1683 ALA ASP GLU GLY MET ALA LEU LEU ASP ALA ALA ILE ALA SEQRES 112 C 1683 THR GLY GLY THR LEU VAL ALA ALA LYS PHE ASP VAL ALA SEQRES 113 C 1683 ALA LEU ARG ALA THR ALA LYS ALA GLY GLY PRO VAL PRO SEQRES 114 C 1683 PRO LEU LEU ARG GLY LEU ALA PRO LEU PRO ARG ARG ALA SEQRES 115 C 1683 ALA ALA LYS THR ALA SER LEU THR GLU ARG LEU ALA GLY SEQRES 116 C 1683 LEU ALA GLU THR GLU GLN ALA ALA ALA LEU LEU ASP LEU SEQRES 117 C 1683 VAL ARG ARG HIS ALA ALA GLU VAL LEU GLY HIS SER GLY SEQRES 118 C 1683 ALA GLU SER VAL HIS SER GLY ARG THR PHE LYS ASP ALA SEQRES 119 C 1683 GLY PHE ASP 4HH LEU THR ALA VAL GLU LEU ARG ASN ARG SEQRES 120 C 1683 LEU ALA ALA ALA THR GLY LEU THR LEU SER PRO ALA MET SEQRES 121 C 1683 ILE PHE ASP TYR PRO LYS PRO PRO ALA LEU ALA ASP HIS SEQRES 122 C 1683 LEU ARG ALA LYS LEU PHE GLY THR GLU VAL ARG GLY GLU SEQRES 123 C 1683 ALA PRO SER ALA LEU ALA GLY LEU ASP ALA LEU GLU ALA SEQRES 124 C 1683 ALA LEU PRO GLU VAL PRO ALA THR GLU ARG GLU GLU LEU SEQRES 125 C 1683 VAL GLN ARG LEU GLU ARG MET LEU ALA ALA LEU ARG PRO SEQRES 126 C 1683 VAL ALA GLN ALA ALA ASP ALA SER GLY THR GLY ALA ASN SEQRES 127 C 1683 PRO SER GLY ASP ASP LEU GLY GLU ALA GLY VAL ASP GLU SEQRES 128 C 1683 LEU LEU GLU ALA LEU GLY ARG GLU LEU ASP GLY ASP GLY SEQRES 129 C 1683 ASN SER SER SER VAL ASP LYS LEU ALA ALA ALA LEU GLU SEQRES 130 C 1683 HIS HIS HIS HIS HIS HIS MODRES 9PAV 4HH C 1538 SER MODIFIED RESIDUE HET 4HH C1538 27 HETNAM 4HH 4'-PHOSPHOPANTHETHEINE-SERINE HETSYN 4HH O-[(S)-HYDROXY{[(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4- HETSYN 2 4HH ({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO) HETSYN 3 4HH BUTYL]OXY}PHOSPHORYL]-L-SERINE FORMUL 7 4HH C14 H28 N3 O9 P S HELIX 1 AA1 SER H 55 GLY H 59 5 5 HELIX 2 AA2 LYS H 91 THR H 95 5 5 HELIX 3 AA3 SER H 163 ALA H 165 5 3 HELIX 4 AA4 GLU L 100 VAL L 104 5 5 HELIX 5 AA5 SER L 143 GLY L 150 1 8 HELIX 6 AA6 LYS L 205 HIS L 211 1 7 HELIX 7 AA7 THR G 30 TYR G 34 5 5 HELIX 8 AA8 SER G 55 GLY G 59 5 5 HELIX 9 AA9 SER G 163 ALA G 165 5 3 HELIX 10 AB1 GLU I 100 VAL I 104 5 5 HELIX 11 AB2 SER I 143 GLY I 150 1 8 HELIX 12 AB3 LYS I 205 HIS I 211 1 7 HELIX 13 AB4 THR A 4 GLU A 33 1 30 HELIX 14 AB5 SER A 50 ALA A 59 1 10 HELIX 15 AB6 LEU A 76 ILE A 80 5 5 HELIX 16 AB7 SER A 112 MET A 119 1 8 HELIX 17 AB8 ASP A 120 ALA A 137 1 18 HELIX 18 AB9 PRO A 141 LYS A 145 5 5 HELIX 19 AC1 ALA A 166 GLU A 170 5 5 HELIX 20 AC2 PHE A 172 ALA A 178 1 7 HELIX 21 AC3 SER A 180 GLY A 191 1 12 HELIX 22 AC4 THR A 201 CYS A 203 5 3 HELIX 23 AC5 SER A 204 GLY A 220 1 17 HELIX 24 AC6 PRO A 236 ARG A 246 1 11 HELIX 25 AC7 LEU A 278 GLY A 285 1 8 HELIX 26 AC8 ASN A 310 GLY A 326 1 17 HELIX 27 AC9 LEU A 344 GLY A 358 1 15 HELIX 28 AD1 SER A 369 ASN A 373 5 5 HELIX 29 AD2 ALA A 377 ALA A 379 5 3 HELIX 30 AD3 ALA A 380 GLU A 396 1 17 HELIX 31 AD4 SER A 477 GLY A 494 1 18 HELIX 32 AD5 LEU A 498 ARG A 508 1 11 HELIX 33 AD6 SER A 522 ALA A 532 1 11 HELIX 34 AD7 GLY A 559 SER A 566 1 8 HELIX 35 AD8 SER A 566 ALA A 581 1 16 HELIX 36 AD9 SER A 587 ARG A 593 1 7 HELIX 37 AE1 ARG A 600 VAL A 622 1 23 HELIX 38 AE2 SER A 633 GLU A 636 5 4 HELIX 39 AE3 ILE A 637 VAL A 642 1 6 HELIX 40 AE4 SER A 647 GLU A 665 1 19 HELIX 41 AE5 GLY A 678 ARG A 685 1 8 HELIX 42 AE6 ASP A 706 GLY A 721 1 16 HELIX 43 AE7 THR A 735 ASP A 740 5 6 HELIX 44 AE8 ILE A 741 LEU A 749 1 9 HELIX 45 AE9 ASP A 777 ASN A 787 1 11 HELIX 46 AF1 ARG A 790 GLN A 801 1 12 HELIX 47 AF2 THR A 815 GLY A 824 1 10 HELIX 48 AF3 GLY A 836 GLY A 851 1 16 HELIX 49 AF4 ASP A 855 MET A 859 5 5 HELIX 50 AF5 ALA A 919 ASP A 921 5 3 HELIX 51 AF6 PRO A 925 GLY A 941 1 17 HELIX 52 AF7 GLY A 972 ARG A 976 5 5 HELIX 53 AF8 HIS A 1031 GLY A 1044 1 14 HELIX 54 AF9 THR A 1101 ASP A 1103 5 3 HELIX 55 AG1 SER A 1130 ASP A 1144 1 15 HELIX 56 AG2 GLU A 1159 HIS A 1176 1 18 HELIX 57 AG3 ASP A 1187 ALA A 1189 5 3 HELIX 58 AG4 VAL A 1190 GLY A 1198 1 9 HELIX 59 AG5 GLY A 1239 ALA A 1252 1 14 HELIX 60 AG6 ALA A 1267 LEU A 1277 1 11 HELIX 61 AG7 ASP A 1290 ALA A 1300 1 11 HELIX 62 AG8 VAL A 1321 LEU A 1325 5 5 HELIX 63 AG9 THR A 1326 ARG A 1335 1 10 HELIX 64 AH1 LYS A 1337 THR A 1348 1 12 HELIX 65 AH2 ALA A 1362 LEU A 1366 1 5 HELIX 66 AH3 GLN A 1371 LEU A 1391 1 21 HELIX 67 AH4 GLY A 1408 HIS A 1412 5 5 HELIX 68 AH5 GLY A 1414 ILE A 1424 1 11 HELIX 69 AH6 PRO A 1430 GLY A 1445 1 16 HELIX 70 AH7 ASP A 1454 GLY A 1465 1 12 HELIX 71 AH8 PRO A 1470 GLY A 1474 5 5 HELIX 72 AH9 ASP B 5 GLU B 33 1 29 HELIX 73 AI1 SER B 50 GLU B 60 1 11 HELIX 74 AI2 ASP B 75 ILE B 80 1 6 HELIX 75 AI3 SER B 112 MET B 119 1 8 HELIX 76 AI4 ASP B 120 ALA B 137 1 18 HELIX 77 AI5 SER B 180 GLY B 191 1 12 HELIX 78 AI6 THR B 201 CYS B 203 5 3 HELIX 79 AI7 SER B 204 GLY B 220 1 17 HELIX 80 AI8 PRO B 236 GLN B 245 1 10 HELIX 81 AI9 LEU B 278 GLY B 285 1 8 HELIX 82 AJ1 ASN B 310 GLY B 326 1 17 HELIX 83 AJ2 LEU B 344 TYR B 357 1 14 HELIX 84 AJ3 SER B 369 ASN B 373 5 5 HELIX 85 AJ4 ALA B 377 ALA B 379 5 3 HELIX 86 AJ5 ALA B 380 GLU B 396 1 17 HELIX 87 AJ6 ASP B 412 GLY B 416 5 5 HELIX 88 AJ7 SER B 477 GLU B 493 1 17 HELIX 89 AJ8 SER B 497 ARG B 508 1 12 HELIX 90 AJ9 SER B 522 LEU B 533 1 12 HELIX 91 AK1 GLY B 559 SER B 566 1 8 HELIX 92 AK2 SER B 566 ALA B 581 1 16 HELIX 93 AK3 PRO B 582 ILE B 584 5 3 HELIX 94 AK4 SER B 587 GLY B 594 1 8 HELIX 95 AK5 ARG B 600 GLY B 623 1 24 HELIX 96 AK6 SER B 633 GLY B 644 1 12 HELIX 97 AK7 SER B 647 LEU B 666 1 20 HELIX 98 AK8 GLY B 678 ARG B 685 1 8 HELIX 99 AK9 ASP B 706 GLY B 719 1 14 HELIX 100 AL1 THR B 735 ASP B 740 5 6 HELIX 101 AL2 ILE B 741 LEU B 749 1 9 HELIX 102 AL3 ASP B 777 ASN B 787 1 11 HELIX 103 AL4 ARG B 790 GLY B 802 1 13 HELIX 104 AL5 THR B 815 GLY B 824 1 10 HELIX 105 AL6 GLY B 836 ARG B 850 1 15 HELIX 106 AL7 ASP B 855 MET B 859 5 5 HELIX 107 AL8 ALA B 919 LEU B 923 5 5 HELIX 108 AL9 PRO B 925 ALA B 940 1 16 HELIX 109 AM1 GLY B 972 ARG B 976 5 5 HELIX 110 AM2 HIS B 1031 GLY B 1044 1 14 HELIX 111 AM3 ALA C 1503 GLY C 1518 1 16 HELIX 112 AM4 THR C 1530 GLY C 1535 1 6 HELIX 113 AM5 ASP C 1537 GLY C 1553 1 17 HELIX 114 AM6 ALA C 1559 TYR C 1564 1 6 HELIX 115 AM7 LYS C 1566 ALA C 1576 1 11 SHEET 1 AA1 4 GLN H 5 SER H 9 0 SHEET 2 AA1 4 SER H 19 SER H 27 -1 O SER H 27 N GLN H 5 SHEET 3 AA1 4 ILE H 82 ASN H 88 -1 O LEU H 85 N LEU H 22 SHEET 4 AA1 4 THR H 73 ASP H 77 -1 N SER H 75 O TYR H 84 SHEET 1 AA2 6 GLY H 12 VAL H 14 0 SHEET 2 AA2 6 THR H 114 VAL H 118 1 O THR H 117 N VAL H 14 SHEET 3 AA2 6 ALA H 96 ARG H 102 -1 N TYR H 98 O THR H 114 SHEET 4 AA2 6 MET H 36 GLN H 41 -1 N SER H 37 O THR H 101 SHEET 5 AA2 6 LEU H 47 ILE H 53 -1 O GLY H 51 N TRP H 38 SHEET 6 AA2 6 THR H 62 TYR H 64 -1 O GLU H 63 N PHE H 52 SHEET 1 AA3 4 GLY H 12 VAL H 14 0 SHEET 2 AA3 4 THR H 114 VAL H 118 1 O THR H 117 N VAL H 14 SHEET 3 AA3 4 ALA H 96 ARG H 102 -1 N TYR H 98 O THR H 114 SHEET 4 AA3 4 TYR H 109 TRP H 110 -1 O TYR H 109 N ARG H 102 SHEET 1 AA4 4 SER H 127 LEU H 131 0 SHEET 2 AA4 4 ALA H 144 TYR H 152 -1 O LEU H 148 N PHE H 129 SHEET 3 AA4 4 TYR H 183 THR H 190 -1 O LEU H 185 N VAL H 149 SHEET 4 AA4 4 VAL H 170 THR H 172 -1 N HIS H 171 O VAL H 188 SHEET 1 AA5 4 SER H 127 LEU H 131 0 SHEET 2 AA5 4 ALA H 144 TYR H 152 -1 O LEU H 148 N PHE H 129 SHEET 3 AA5 4 TYR H 183 THR H 190 -1 O LEU H 185 N VAL H 149 SHEET 4 AA5 4 VAL H 176 LEU H 177 -1 N VAL H 176 O SER H 184 SHEET 1 AA6 3 THR H 158 TRP H 161 0 SHEET 2 AA6 3 ILE H 202 HIS H 207 -1 O ASN H 204 N SER H 160 SHEET 3 AA6 3 THR H 212 LYS H 217 -1 O VAL H 214 N VAL H 205 SHEET 1 AA7 3 ALA L 35 CYS L 39 0 SHEET 2 AA7 3 ASP L 91 ILE L 96 -1 O LEU L 94 N ILE L 37 SHEET 3 AA7 3 PHE L 83 SER L 88 -1 N SER L 86 O THR L 93 SHEET 1 AA8 5 ASN L 74 ARG L 75 0 SHEET 2 AA8 5 PRO L 65 TYR L 70 -1 N TYR L 70 O ASN L 74 SHEET 3 AA8 5 LEU L 54 GLN L 59 -1 N LEU L 58 O GLN L 66 SHEET 4 AA8 5 GLY L 105 GLN L 111 -1 O VAL L 106 N GLN L 59 SHEET 5 AA8 5 THR L 124 VAL L 126 -1 O THR L 124 N TYR L 107 SHEET 1 AA9 4 PHE L 138 PHE L 140 0 SHEET 2 AA9 4 THR L 151 PHE L 161 -1 O LEU L 157 N PHE L 138 SHEET 3 AA9 4 TYR L 195 SER L 204 -1 O TYR L 195 N PHE L 161 SHEET 4 AA9 4 SER L 181 VAL L 185 -1 N GLN L 182 O THR L 200 SHEET 1 AB1 3 LYS L 167 TRP L 170 0 SHEET 2 AB1 3 CYS L 216 THR L 219 -1 O THR L 219 N LYS L 167 SHEET 3 AB1 3 VAL L 227 LYS L 229 -1 O LYS L 229 N CYS L 216 SHEET 1 AB2 4 GLN G 5 SER G 9 0 SHEET 2 AB2 4 SER G 19 SER G 27 -1 O SER G 27 N GLN G 5 SHEET 3 AB2 4 ILE G 82 ASN G 88 -1 O LEU G 85 N LEU G 22 SHEET 4 AB2 4 THR G 73 ASP G 77 -1 N SER G 75 O TYR G 84 SHEET 1 AB3 2 LEU G 13 VAL G 14 0 SHEET 2 AB3 2 THR G 117 VAL G 118 1 O THR G 117 N VAL G 14 SHEET 1 AB4 5 THR G 62 TYR G 64 0 SHEET 2 AB4 5 LEU G 47 ILE G 53 -1 N PHE G 52 O GLU G 63 SHEET 3 AB4 5 MET G 36 GLN G 41 -1 N ARG G 40 O GLU G 48 SHEET 4 AB4 5 VAL G 97 ARG G 102 -1 O THR G 101 N SER G 37 SHEET 5 AB4 5 TYR G 109 TRP G 110 -1 O TYR G 109 N ARG G 102 SHEET 1 AB5 5 THR G 62 TYR G 64 0 SHEET 2 AB5 5 LEU G 47 ILE G 53 -1 N PHE G 52 O GLU G 63 SHEET 3 AB5 5 MET G 36 GLN G 41 -1 N ARG G 40 O GLU G 48 SHEET 4 AB5 5 VAL G 97 ARG G 102 -1 O THR G 101 N SER G 37 SHEET 5 AB5 5 THR G 114 LEU G 115 -1 O THR G 114 N TYR G 98 SHEET 1 AB6 4 SER G 127 LEU G 131 0 SHEET 2 AB6 4 ALA G 144 TYR G 152 -1 O LYS G 150 N SER G 127 SHEET 3 AB6 4 TYR G 183 THR G 190 -1 O TYR G 183 N TYR G 152 SHEET 4 AB6 4 HIS G 171 LEU G 177 -1 N HIS G 171 O VAL G 188 SHEET 1 AB7 3 VAL G 157 TRP G 161 0 SHEET 2 AB7 3 ILE G 202 HIS G 207 -1 O ASN G 206 N THR G 158 SHEET 3 AB7 3 THR G 212 LYS G 217 -1 O VAL G 214 N VAL G 205 SHEET 1 AB8 4 THR I 21 GLN I 22 0 SHEET 2 AB8 4 ALA I 35 SER I 41 -1 O ARG I 40 N GLN I 22 SHEET 3 AB8 4 ASP I 91 ILE I 96 -1 O LEU I 94 N ILE I 37 SHEET 4 AB8 4 PHE I 83 SER I 88 -1 N SER I 86 O THR I 93 SHEET 1 AB9 4 GLN I 66 TYR I 70 0 SHEET 2 AB9 4 LEU I 54 GLN I 59 -1 N LEU I 58 O GLN I 66 SHEET 3 AB9 4 GLY I 105 GLN I 111 -1 O MET I 110 N ASP I 55 SHEET 4 AB9 4 THR I 124 VAL I 126 -1 O THR I 124 N TYR I 107 SHEET 1 AC1 4 SER I 136 ILE I 139 0 SHEET 2 AC1 4 THR I 151 PHE I 161 -1 O LEU I 157 N PHE I 138 SHEET 3 AC1 4 TYR I 195 SER I 204 -1 O TYR I 195 N PHE I 161 SHEET 4 AC1 4 SER I 181 VAL I 185 -1 N SER I 184 O SER I 198 SHEET 1 AC2 3 LYS I 167 TRP I 170 0 SHEET 2 AC2 3 CYS I 216 THR I 219 -1 O THR I 219 N LYS I 167 SHEET 3 AC2 3 VAL I 227 LYS I 229 -1 O LYS I 229 N CYS I 216 SHEET 1 AC321 ILE A 418 LEU A 420 0 SHEET 2 AC321 LEU A 365 GLY A 368 1 N LEU A 365 O GLU A 419 SHEET 3 AC321 VAL A 334 GLU A 336 1 N VAL A 335 O TRP A 366 SHEET 4 AC321 ARG A 435 PHE A 441 1 O GLY A 437 N GLU A 336 SHEET 5 AC321 THR A 446 GLU A 454 -1 O LEU A 452 N ALA A 436 SHEET 6 AC321 ALA A 290 GLN A 299 -1 N VAL A 291 O GLU A 453 SHEET 7 AC321 ILE A 35 ARG A 43 -1 N ILE A 37 O ALA A 290 SHEET 8 AC321 GLY A 269 ARG A 277 -1 O GLU A 276 N ALA A 36 SHEET 9 AC321 ALA A 225 THR A 231 -1 N GLY A 229 O GLY A 271 SHEET 10 AC321 GLY A 150 GLY A 154 1 N GLY A 154 O GLY A 228 SHEET 11 AC321 ALA A 196 ASP A 200 1 O VAL A 199 N SER A 153 SHEET 12 AC321 ALA B 196 VAL B 199 -1 O THR B 198 N ASP A 200 SHEET 13 AC321 GLY B 150 GLY B 154 1 N SER B 153 O VAL B 199 SHEET 14 AC321 ALA B 225 THR B 231 1 O VAL B 230 N GLY B 154 SHEET 15 AC321 GLY B 269 ARG B 277 -1 O VAL B 273 N ALA B 227 SHEET 16 AC321 ILE B 35 ARG B 43 -1 N ALA B 36 O GLU B 276 SHEET 17 AC321 ALA B 290 ASN B 298 -1 O LEU B 292 N ILE B 35 SHEET 18 AC321 ASN B 447 GLU B 454 -1 O GLU B 453 N VAL B 291 SHEET 19 AC321 ARG B 435 PHE B 441 -1 N ALA B 436 O LEU B 452 SHEET 20 AC321 VAL B 334 GLU B 336 1 N GLU B 336 O GLY B 437 SHEET 21 AC321 TRP B 366 GLY B 368 1 O TRP B 366 N VAL B 335 SHEET 1 AC4 2 SER A 66 GLU A 67 0 SHEET 2 AC4 2 GLN A 94 GLY A 95 -1 O GLY A 95 N SER A 66 SHEET 1 AC5 2 GLU A 103 PHE A 104 0 SHEET 2 AC5 2 ARG A 876 HIS A 877 -1 O ARG A 876 N PHE A 104 SHEET 1 AC6 2 THR A 397 LEU A 398 0 SHEET 2 AC6 2 ARG A 425 ALA A 426 -1 O ARG A 425 N LEU A 398 SHEET 1 AC7 2 VAL A 469 ALA A 475 0 SHEET 2 AC7 2 GLU A 514 ALA A 520 -1 O VAL A 518 N LEU A 471 SHEET 1 AC8 4 ALA A 628 GLY A 631 0 SHEET 2 AC8 4 VAL A 544 PHE A 548 1 N TRP A 546 O VAL A 630 SHEET 3 AC8 4 VAL A 805 GLU A 808 1 O VAL A 807 N VAL A 547 SHEET 4 AC8 4 ALA A 826 GLY A 828 1 O ILE A 827 N GLU A 808 SHEET 1 AC9 4 VAL A 690 VAL A 692 0 SHEET 2 AC9 4 VAL A 701 GLY A 705 -1 O ALA A 704 N GLU A 691 SHEET 3 AC9 4 GLY A 671 VAL A 675 -1 N ALA A 673 O ILE A 703 SHEET 4 AC9 4 VAL A 724 VAL A 727 -1 O ARG A 725 N SER A 674 SHEET 1 AD111 THR A 895 SER A 898 0 SHEET 2 AD111 LEU A 905 TRP A 911 -1 O THR A 906 N VAL A 897 SHEET 3 AD111 ARG A 962 VAL A 968 -1 O VAL A 968 N LEU A 905 SHEET 4 AD111 ARG A 977 ARG A 984 -1 O ARG A 984 N GLU A 963 SHEET 5 AD111 THR A 991 ALA A 999 -1 O HIS A 993 N VAL A 981 SHEET 6 AD111 VAL A 944 VAL A 949 -1 N VAL A 949 O HIS A 995 SHEET 7 AD111 LEU A1048 LEU A1057 -1 O TRP A1052 N LEU A 948 SHEET 8 AD111 PRO A1083 THR A1093 -1 O THR A1093 N LEU A1048 SHEET 9 AD111 LEU A1074 THR A1077 -1 N LEU A1076 O LEU A1085 SHEET 10 AD111 VAL A1065 PRO A1069 -1 N THR A1068 O ARG A1075 SHEET 11 AD111 THR A1015 VAL A1017 -1 N THR A1015 O VAL A1067 SHEET 1 AD2 2 LEU A 923 VAL A 924 0 SHEET 2 AD2 2 VAL A 954 VAL A 955 -1 O VAL A 954 N VAL A 924 SHEET 1 AD3 9 ARG A1213 ARG A1216 0 SHEET 2 AD3 9 LEU A1105 ASP A1109 -1 N ASP A1109 O ARG A1213 SHEET 3 AD3 9 GLY A1446 ALA A1450 -1 O VAL A1449 N PHE A1106 SHEET 4 AD3 9 VAL A1396 TRP A1400 1 N ALA A1399 O LEU A1448 SHEET 5 AD3 9 PHE A1356 SER A1361 1 N PHE A1356 O VAL A1396 SHEET 6 AD3 9 LEU A1307 HIS A1312 1 N HIS A1312 O PHE A1359 SHEET 7 AD3 9 THR A1231 THR A1235 1 N THR A1231 O THR A1308 SHEET 8 AD3 9 HIS A1257 SER A1262 1 O VAL A1259 N ILE A1234 SHEET 9 AD3 9 SER A1280 ALA A1285 1 O ALA A1282 N LEU A1258 SHEET 1 AD4 6 GLU A1112 ILE A1113 0 SHEET 2 AD4 6 VAL A1208 SER A1210 -1 O ALA A1209 N ILE A1113 SHEET 3 AD4 6 GLN A1201 ARG A1205 -1 N ARG A1205 O VAL A1208 SHEET 4 AD4 6 ILE A1180 LEU A1185 1 N LEU A1182 O VAL A1202 SHEET 5 AD4 6 LEU A1150 THR A1154 1 N VAL A1152 O VAL A1181 SHEET 6 AD4 6 LEU A1124 GLU A1127 1 N LEU A1124 O ALA A1151 SHEET 1 AD5 2 SER B 66 GLU B 67 0 SHEET 2 AD5 2 GLN B 94 GLY B 95 -1 O GLY B 95 N SER B 66 SHEET 1 AD6 2 GLU B 103 PHE B 104 0 SHEET 2 AD6 2 ARG B 876 HIS B 877 -1 O ARG B 876 N PHE B 104 SHEET 1 AD7 2 THR B 397 LEU B 398 0 SHEET 2 AD7 2 ARG B 425 ALA B 426 -1 O ARG B 425 N LEU B 398 SHEET 1 AD8 2 VAL B 469 ALA B 475 0 SHEET 2 AD8 2 GLU B 514 ALA B 520 -1 O ALA B 516 N VAL B 473 SHEET 1 AD9 4 ALA B 628 GLY B 631 0 SHEET 2 AD9 4 VAL B 544 PHE B 548 1 N TRP B 546 O ALA B 628 SHEET 3 AD9 4 VAL B 805 GLU B 808 1 O VAL B 807 N VAL B 545 SHEET 4 AD9 4 ALA B 826 GLY B 828 1 O ILE B 827 N GLU B 808 SHEET 1 AE1 4 VAL B 690 VAL B 692 0 SHEET 2 AE1 4 ILE B 703 GLY B 705 -1 N ALA B 704 O GLU B 691 SHEET 3 AE1 4 GLY B 671 VAL B 675 -1 N ALA B 673 O ILE B 703 SHEET 4 AE1 4 VAL B 724 ARG B 726 -1 O ARG B 725 N SER B 674 SHEET 1 AE2 2 PHE B 761 SER B 763 0 SHEET 2 AE2 2 GLU B 768 VAL B 770 -1 O VAL B 770 N PHE B 761 SHEET 1 AE3 8 THR B 895 SER B 898 0 SHEET 2 AE3 8 LEU B 905 TRP B 911 -1 O VAL B 908 N THR B 895 SHEET 3 AE3 8 ARG B 962 VAL B 968 -1 O LEU B 966 N ALA B 907 SHEET 4 AE3 8 ARG B 977 ARG B 984 -1 O PHE B 982 N GLN B 965 SHEET 5 AE3 8 ALA B 994 LEU B 998 -1 O GLY B 996 N ILE B 979 SHEET 6 AE3 8 VAL B 945 VAL B 950 -1 N VAL B 949 O HIS B 995 SHEET 7 AE3 8 LEU B1048 THR B1053 -1 O TRP B1052 N LEU B 948 SHEET 8 AE3 8 SER B1089 THR B1093 -1 O ARG B1091 N VAL B1051 SHEET 1 AE4 5 THR B1015 VAL B1017 0 SHEET 2 AE4 5 VAL B1065 PRO B1069 -1 O VAL B1065 N VAL B1017 SHEET 3 AE4 5 LEU B1074 THR B1077 -1 O ARG B1075 N THR B1068 SHEET 4 AE4 5 PRO B1083 THR B1086 -1 O VAL B1084 N LEU B1076 SHEET 5 AE4 5 SER B1056 LEU B1057 -1 N SER B1056 O THR B1086 SSBOND 1 CYS H 147 CYS H 203 1555 1555 2.03 SSBOND 2 CYS L 39 CYS L 109 1555 1555 2.04 SSBOND 3 CYS L 156 CYS L 216 1555 1555 2.03 SSBOND 4 CYS G 147 CYS G 203 1555 1555 2.03 SSBOND 5 CYS I 39 CYS I 109 1555 1555 2.04 SSBOND 6 CYS I 156 CYS I 216 1555 1555 2.03 LINK C ASP C1537 N 4HH C1538 1555 1555 1.33 LINK C 4HH C1538 N LEU C1539 1555 1555 1.33 CISPEP 1 PHE H 153 PRO H 154 0 -5.76 CISPEP 2 GLU H 155 PRO H 156 0 -1.54 CISPEP 3 THR L 115 PRO L 116 0 -1.04 CISPEP 4 TYR L 162 PRO L 163 0 -6.20 CISPEP 5 PHE G 153 PRO G 154 0 -4.38 CISPEP 6 GLU G 155 PRO G 156 0 -3.60 CISPEP 7 THR I 115 PRO I 116 0 -1.63 CISPEP 8 TYR I 162 PRO I 163 0 -3.26 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000