HEADER VIRAL PROTEIN 26-FEB-25 9Q9N TITLE HSV-1 PREFUSION GLYCOPROTEIN B BOUND BY NB1_GBHSV COMPND MOL_ID: 1; COMPND 2 MOLECULE: GLYCOPROTEIN B; COMPND 3 CHAIN: A, B, C; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: NB1_GBHSV; COMPND 7 CHAIN: d, e, f; COMPND 8 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HUMAN ALPHAHERPESVIRUS 1 STRAIN 17; SOURCE 3 ORGANISM_TAXID: 10299; SOURCE 4 GENE: UL27, HHV1GP041; SOURCE 5 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 6 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 7 EXPRESSION_SYSTEM_CELL_LINE: HEK-293T; SOURCE 8 EXPRESSION_SYSTEM_ATCC_NUMBER: CRL-3216; SOURCE 9 EXPRESSION_SYSTEM_ORGAN: KIDNEY; SOURCE 10 EXPRESSION_SYSTEM_VECTOR_TYPE: LENTI; SOURCE 11 EXPRESSION_SYSTEM_PLASMID: PHR-CAG; SOURCE 12 MOL_ID: 2; SOURCE 13 ORGANISM_SCIENTIFIC: VICUGNA PACOS; SOURCE 14 ORGANISM_TAXID: 30538; SOURCE 15 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 16 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 17 EXPRESSION_SYSTEM_STRAIN: C3029; SOURCE 18 EXPRESSION_SYSTEM_VARIANT: SHUFFLE; SOURCE 19 EXPRESSION_SYSTEM_PLASMID: PQE80 DERIVATIVE KEYWDS GLYCOPROTEIN B, VIRAL MEMBRANE FUSION PROTEIN, HERPES SIMPLEX VIRUS KEYWDS 2 1, NANOBODY, VIRAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR B.VOLLMER,T.MULVANEY,H.EBEL,J.NENTWIG,K.GRUENEWALD REVDAT 1 03-SEP-25 9Q9N 0 JRNL AUTH B.VOLLMER,H.EBEL,R.REES,J.NENTWIG,T.MULVANEY,J.SCHUENEMANN, JRNL AUTH 2 J.KRULL,M.TOPF,D.GOERLICH,K.GRUENEWALD JRNL TITL A NANOBODY SPECIFIC TO PREFUSION GLYCOPROTEIN B NEUTRALIZES JRNL TITL 2 HSV-1 AND HSV-2 JRNL REF NATURE 2025 JRNL REFN ESSN 1476-4687 JRNL DOI 10.1038/S41586-025-09438-5 REMARK 2 REMARK 2 RESOLUTION. 3.00 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : WARP, SERIALEM, CRYOSPARC, ISOLDE, REMARK 3 CRYOSPARC, CRYOSPARC, CRYOSPARC, PHENIX REMARK 3 RECONSTRUCTION SCHEMA : BACK PROJECTION REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : REAL REMARK 3 REFINEMENT PROTOCOL : AB INITIO MODEL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : 59.590 REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.000 REMARK 3 NUMBER OF PARTICLES : 394394 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9Q9N COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 26-FEB-25. REMARK 100 THE DEPOSITION ID IS D_1292145762. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : GLYCOPROTEIN B BOUND BY REMARK 245 NB1_GBHSV; NB1_GBHSV; REMARK 245 GLYCOPROTEIN B REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.10 REMARK 245 SAMPLE SUPPORT DETAILS : GRID WAS OVERLAYED WITH 2 NM REMARK 245 CARBON REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.80 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 3066 REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : 2.70 REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 4583.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : 130000 REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, d, e, f, D, E, F, G, REMARK 350 AND CHAINS: H, I, J, K, L, M, N, O REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 HIS A 2 REMARK 465 GLN A 3 REMARK 465 GLY A 4 REMARK 465 ALA A 5 REMARK 465 PRO A 6 REMARK 465 SER A 7 REMARK 465 TRP A 8 REMARK 465 GLY A 9 REMARK 465 ARG A 10 REMARK 465 ARG A 11 REMARK 465 TRP A 12 REMARK 465 PHE A 13 REMARK 465 VAL A 14 REMARK 465 VAL A 15 REMARK 465 TRP A 16 REMARK 465 ALA A 17 REMARK 465 LEU A 18 REMARK 465 LEU A 19 REMARK 465 GLY A 20 REMARK 465 LEU A 21 REMARK 465 THR A 22 REMARK 465 LEU A 23 REMARK 465 GLY A 24 REMARK 465 VAL A 25 REMARK 465 LEU A 26 REMARK 465 VAL A 27 REMARK 465 ALA A 28 REMARK 465 SER A 29 REMARK 465 ALA A 30 REMARK 465 ALA A 31 REMARK 465 PRO A 32 REMARK 465 SER A 33 REMARK 465 SER A 34 REMARK 465 PRO A 35 REMARK 465 GLY A 36 REMARK 465 THR A 37 REMARK 465 PRO A 38 REMARK 465 GLY A 39 REMARK 465 VAL A 40 REMARK 465 ALA A 41 REMARK 465 ALA A 42 REMARK 465 ALA A 43 REMARK 465 THR A 44 REMARK 465 GLN A 45 REMARK 465 ALA A 46 REMARK 465 ALA A 47 REMARK 465 ASN A 48 REMARK 465 GLY A 49 REMARK 465 GLY A 50 REMARK 465 PRO A 51 REMARK 465 ALA A 52 REMARK 465 THR A 53 REMARK 465 PRO A 54 REMARK 465 ALA A 55 REMARK 465 PRO A 56 REMARK 465 PRO A 57 REMARK 465 ALA A 58 REMARK 465 LEU A 59 REMARK 465 GLY A 60 REMARK 465 ALA A 61 REMARK 465 ALA A 62 REMARK 465 PRO A 63 REMARK 465 THR A 64 REMARK 465 GLY A 65 REMARK 465 ASP A 66 REMARK 465 PRO A 67 REMARK 465 LYS A 68 REMARK 465 PRO A 69 REMARK 465 LYS A 70 REMARK 465 LYS A 71 REMARK 465 ASN A 72 REMARK 465 LYS A 73 REMARK 465 LYS A 74 REMARK 465 PRO A 75 REMARK 465 LYS A 76 REMARK 465 ASN A 77 REMARK 465 PRO A 78 REMARK 465 THR A 79 REMARK 465 PRO A 80 REMARK 465 PRO A 81 REMARK 465 ARG A 82 REMARK 465 PRO A 83 REMARK 465 ALA A 84 REMARK 465 GLY A 85 REMARK 465 ASP A 86 REMARK 465 ASN A 87 REMARK 465 ALA A 88 REMARK 465 THR A 89 REMARK 465 LYS A 475 REMARK 465 PRO A 476 REMARK 465 PRO A 477 REMARK 465 ASN A 478 REMARK 465 PRO A 479 REMARK 465 THR A 480 REMARK 465 PRO A 481 REMARK 465 PRO A 482 REMARK 465 PRO A 483 REMARK 465 PRO A 484 REMARK 465 GLY A 485 REMARK 465 ALA A 486 REMARK 465 SER A 487 REMARK 465 ALA A 488 REMARK 465 ASN A 489 REMARK 465 ALA A 490 REMARK 465 SER A 491 REMARK 465 VAL A 492 REMARK 465 GLU A 493 REMARK 465 ARG A 494 REMARK 465 ILE A 495 REMARK 465 LYS A 496 REMARK 465 THR A 497 REMARK 465 THR A 498 REMARK 465 SER A 499 REMARK 465 SER A 500 REMARK 465 LEU A 809 REMARK 465 TYR A 810 REMARK 465 PRO A 811 REMARK 465 LEU A 812 REMARK 465 THR A 813 REMARK 465 THR A 814 REMARK 465 LYS A 815 REMARK 465 GLU A 816 REMARK 465 LEU A 817 REMARK 465 LYS A 818 REMARK 465 ASN A 819 REMARK 465 PRO A 820 REMARK 465 THR A 821 REMARK 465 ASN A 822 REMARK 465 PRO A 823 REMARK 465 ASP A 824 REMARK 465 ALA A 825 REMARK 465 SER A 826 REMARK 465 GLY A 827 REMARK 465 GLU A 828 REMARK 465 GLY A 829 REMARK 465 GLU A 830 REMARK 465 GLU A 831 REMARK 465 GLY A 832 REMARK 465 GLY A 833 REMARK 465 ASP A 834 REMARK 465 PHE A 835 REMARK 465 ASP A 836 REMARK 465 GLU A 837 REMARK 465 ALA A 838 REMARK 465 LYS A 839 REMARK 465 LEU A 840 REMARK 465 ALA A 841 REMARK 465 GLU A 842 REMARK 465 ALA A 843 REMARK 465 ARG A 844 REMARK 465 GLU A 845 REMARK 465 MET A 846 REMARK 465 ILE A 847 REMARK 465 ARG A 848 REMARK 465 TYR A 849 REMARK 465 MET A 850 REMARK 465 ALA A 851 REMARK 465 LEU A 852 REMARK 465 VAL A 853 REMARK 465 SER A 854 REMARK 465 ALA A 855 REMARK 465 MET A 856 REMARK 465 GLU A 857 REMARK 465 ARG A 858 REMARK 465 THR A 859 REMARK 465 GLU A 860 REMARK 465 HIS A 861 REMARK 465 LYS A 862 REMARK 465 ALA A 863 REMARK 465 LYS A 864 REMARK 465 LYS A 865 REMARK 465 LYS A 866 REMARK 465 GLY A 867 REMARK 465 THR A 868 REMARK 465 SER A 869 REMARK 465 ALA A 870 REMARK 465 LEU A 871 REMARK 465 LEU A 872 REMARK 465 SER A 873 REMARK 465 ALA A 874 REMARK 465 LYS A 875 REMARK 465 VAL A 876 REMARK 465 THR A 877 REMARK 465 ASP A 878 REMARK 465 MET A 879 REMARK 465 VAL A 880 REMARK 465 MET A 881 REMARK 465 ARG A 882 REMARK 465 LYS A 883 REMARK 465 ARG A 884 REMARK 465 ARG A 885 REMARK 465 ASN A 886 REMARK 465 THR A 887 REMARK 465 ASN A 888 REMARK 465 ALA A 889 REMARK 465 THR A 890 REMARK 465 GLN A 891 REMARK 465 VAL A 892 REMARK 465 PRO A 893 REMARK 465 ASN A 894 REMARK 465 LYS A 895 REMARK 465 ASP A 896 REMARK 465 GLY A 897 REMARK 465 ASP A 898 REMARK 465 ALA A 899 REMARK 465 ASP A 900 REMARK 465 GLU A 901 REMARK 465 ASP A 902 REMARK 465 ASP A 903 REMARK 465 LEU A 904 REMARK 465 GLN A 905 REMARK 465 LEU A 906 REMARK 465 GLY A 907 REMARK 465 SER A 908 REMARK 465 GLY A 909 REMARK 465 SER A 910 REMARK 465 GLY A 911 REMARK 465 THR A 912 REMARK 465 LEU A 913 REMARK 465 GLU A 914 REMARK 465 VAL A 915 REMARK 465 LEU A 916 REMARK 465 PHE A 917 REMARK 465 GLN A 918 REMARK 465 GLY A 919 REMARK 465 PRO A 920 REMARK 465 GLY A 921 REMARK 465 GLY A 922 REMARK 465 SER A 923 REMARK 465 GLY A 924 REMARK 465 SER A 925 REMARK 465 ALA A 926 REMARK 465 TRP A 927 REMARK 465 SER A 928 REMARK 465 HIS A 929 REMARK 465 PRO A 930 REMARK 465 GLN A 931 REMARK 465 PHE A 932 REMARK 465 GLU A 933 REMARK 465 LYS A 934 REMARK 465 GLY A 935 REMARK 465 GLY A 936 REMARK 465 GLY A 937 REMARK 465 SER A 938 REMARK 465 GLY A 939 REMARK 465 GLY A 940 REMARK 465 GLY A 941 REMARK 465 SER A 942 REMARK 465 GLY A 943 REMARK 465 GLY A 944 REMARK 465 SER A 945 REMARK 465 ALA A 946 REMARK 465 TRP A 947 REMARK 465 SER A 948 REMARK 465 HIS A 949 REMARK 465 PRO A 950 REMARK 465 GLN A 951 REMARK 465 PHE A 952 REMARK 465 GLU A 953 REMARK 465 LYS A 954 REMARK 465 MET B 1 REMARK 465 HIS B 2 REMARK 465 GLN B 3 REMARK 465 GLY B 4 REMARK 465 ALA B 5 REMARK 465 PRO B 6 REMARK 465 SER B 7 REMARK 465 TRP B 8 REMARK 465 GLY B 9 REMARK 465 ARG B 10 REMARK 465 ARG B 11 REMARK 465 TRP B 12 REMARK 465 PHE B 13 REMARK 465 VAL B 14 REMARK 465 VAL B 15 REMARK 465 TRP B 16 REMARK 465 ALA B 17 REMARK 465 LEU B 18 REMARK 465 LEU B 19 REMARK 465 GLY B 20 REMARK 465 LEU B 21 REMARK 465 THR B 22 REMARK 465 LEU B 23 REMARK 465 GLY B 24 REMARK 465 VAL B 25 REMARK 465 LEU B 26 REMARK 465 VAL B 27 REMARK 465 ALA B 28 REMARK 465 SER B 29 REMARK 465 ALA B 30 REMARK 465 ALA B 31 REMARK 465 PRO B 32 REMARK 465 SER B 33 REMARK 465 SER B 34 REMARK 465 PRO B 35 REMARK 465 GLY B 36 REMARK 465 THR B 37 REMARK 465 PRO B 38 REMARK 465 GLY B 39 REMARK 465 VAL B 40 REMARK 465 ALA B 41 REMARK 465 ALA B 42 REMARK 465 ALA B 43 REMARK 465 THR B 44 REMARK 465 GLN B 45 REMARK 465 ALA B 46 REMARK 465 ALA B 47 REMARK 465 ASN B 48 REMARK 465 GLY B 49 REMARK 465 GLY B 50 REMARK 465 PRO B 51 REMARK 465 ALA B 52 REMARK 465 THR B 53 REMARK 465 PRO B 54 REMARK 465 ALA B 55 REMARK 465 PRO B 56 REMARK 465 PRO B 57 REMARK 465 ALA B 58 REMARK 465 LEU B 59 REMARK 465 GLY B 60 REMARK 465 ALA B 61 REMARK 465 ALA B 62 REMARK 465 PRO B 63 REMARK 465 THR B 64 REMARK 465 GLY B 65 REMARK 465 ASP B 66 REMARK 465 PRO B 67 REMARK 465 LYS B 68 REMARK 465 PRO B 69 REMARK 465 LYS B 70 REMARK 465 LYS B 71 REMARK 465 ASN B 72 REMARK 465 LYS B 73 REMARK 465 LYS B 74 REMARK 465 PRO B 75 REMARK 465 LYS B 76 REMARK 465 ASN B 77 REMARK 465 PRO B 78 REMARK 465 THR B 79 REMARK 465 PRO B 80 REMARK 465 PRO B 81 REMARK 465 ARG B 82 REMARK 465 PRO B 83 REMARK 465 ALA B 84 REMARK 465 GLY B 85 REMARK 465 ASP B 86 REMARK 465 ASN B 87 REMARK 465 ALA B 88 REMARK 465 THR B 89 REMARK 465 LYS B 475 REMARK 465 PRO B 476 REMARK 465 PRO B 477 REMARK 465 ASN B 478 REMARK 465 PRO B 479 REMARK 465 THR B 480 REMARK 465 PRO B 481 REMARK 465 PRO B 482 REMARK 465 PRO B 483 REMARK 465 PRO B 484 REMARK 465 GLY B 485 REMARK 465 ALA B 486 REMARK 465 SER B 487 REMARK 465 ALA B 488 REMARK 465 ASN B 489 REMARK 465 ALA B 490 REMARK 465 SER B 491 REMARK 465 VAL B 492 REMARK 465 GLU B 493 REMARK 465 ARG B 494 REMARK 465 ILE B 495 REMARK 465 LYS B 496 REMARK 465 THR B 497 REMARK 465 THR B 498 REMARK 465 SER B 499 REMARK 465 SER B 500 REMARK 465 LEU B 809 REMARK 465 TYR B 810 REMARK 465 PRO B 811 REMARK 465 LEU B 812 REMARK 465 THR B 813 REMARK 465 THR B 814 REMARK 465 LYS B 815 REMARK 465 GLU B 816 REMARK 465 LEU B 817 REMARK 465 LYS B 818 REMARK 465 ASN B 819 REMARK 465 PRO B 820 REMARK 465 THR B 821 REMARK 465 ASN B 822 REMARK 465 PRO B 823 REMARK 465 ASP B 824 REMARK 465 ALA B 825 REMARK 465 SER B 826 REMARK 465 GLY B 827 REMARK 465 GLU B 828 REMARK 465 GLY B 829 REMARK 465 GLU B 830 REMARK 465 GLU B 831 REMARK 465 GLY B 832 REMARK 465 GLY B 833 REMARK 465 ASP B 834 REMARK 465 PHE B 835 REMARK 465 ASP B 836 REMARK 465 GLU B 837 REMARK 465 ALA B 838 REMARK 465 LYS B 839 REMARK 465 LEU B 840 REMARK 465 ALA B 841 REMARK 465 GLU B 842 REMARK 465 ALA B 843 REMARK 465 ARG B 844 REMARK 465 GLU B 845 REMARK 465 MET B 846 REMARK 465 ILE B 847 REMARK 465 ARG B 848 REMARK 465 TYR B 849 REMARK 465 MET B 850 REMARK 465 ALA B 851 REMARK 465 LEU B 852 REMARK 465 VAL B 853 REMARK 465 SER B 854 REMARK 465 ALA B 855 REMARK 465 MET B 856 REMARK 465 GLU B 857 REMARK 465 ARG B 858 REMARK 465 THR B 859 REMARK 465 GLU B 860 REMARK 465 HIS B 861 REMARK 465 LYS B 862 REMARK 465 ALA B 863 REMARK 465 LYS B 864 REMARK 465 LYS B 865 REMARK 465 LYS B 866 REMARK 465 GLY B 867 REMARK 465 THR B 868 REMARK 465 SER B 869 REMARK 465 ALA B 870 REMARK 465 LEU B 871 REMARK 465 LEU B 872 REMARK 465 SER B 873 REMARK 465 ALA B 874 REMARK 465 LYS B 875 REMARK 465 VAL B 876 REMARK 465 THR B 877 REMARK 465 ASP B 878 REMARK 465 MET B 879 REMARK 465 VAL B 880 REMARK 465 MET B 881 REMARK 465 ARG B 882 REMARK 465 LYS B 883 REMARK 465 ARG B 884 REMARK 465 ARG B 885 REMARK 465 ASN B 886 REMARK 465 THR B 887 REMARK 465 ASN B 888 REMARK 465 ALA B 889 REMARK 465 THR B 890 REMARK 465 GLN B 891 REMARK 465 VAL B 892 REMARK 465 PRO B 893 REMARK 465 ASN B 894 REMARK 465 LYS B 895 REMARK 465 ASP B 896 REMARK 465 GLY B 897 REMARK 465 ASP B 898 REMARK 465 ALA B 899 REMARK 465 ASP B 900 REMARK 465 GLU B 901 REMARK 465 ASP B 902 REMARK 465 ASP B 903 REMARK 465 LEU B 904 REMARK 465 GLN B 905 REMARK 465 LEU B 906 REMARK 465 GLY B 907 REMARK 465 SER B 908 REMARK 465 GLY B 909 REMARK 465 SER B 910 REMARK 465 GLY B 911 REMARK 465 THR B 912 REMARK 465 LEU B 913 REMARK 465 GLU B 914 REMARK 465 VAL B 915 REMARK 465 LEU B 916 REMARK 465 PHE B 917 REMARK 465 GLN B 918 REMARK 465 GLY B 919 REMARK 465 PRO B 920 REMARK 465 GLY B 921 REMARK 465 GLY B 922 REMARK 465 SER B 923 REMARK 465 GLY B 924 REMARK 465 SER B 925 REMARK 465 ALA B 926 REMARK 465 TRP B 927 REMARK 465 SER B 928 REMARK 465 HIS B 929 REMARK 465 PRO B 930 REMARK 465 GLN B 931 REMARK 465 PHE B 932 REMARK 465 GLU B 933 REMARK 465 LYS B 934 REMARK 465 GLY B 935 REMARK 465 GLY B 936 REMARK 465 GLY B 937 REMARK 465 SER B 938 REMARK 465 GLY B 939 REMARK 465 GLY B 940 REMARK 465 GLY B 941 REMARK 465 SER B 942 REMARK 465 GLY B 943 REMARK 465 GLY B 944 REMARK 465 SER B 945 REMARK 465 ALA B 946 REMARK 465 TRP B 947 REMARK 465 SER B 948 REMARK 465 HIS B 949 REMARK 465 PRO B 950 REMARK 465 GLN B 951 REMARK 465 PHE B 952 REMARK 465 GLU B 953 REMARK 465 LYS B 954 REMARK 465 MET C 1 REMARK 465 HIS C 2 REMARK 465 GLN C 3 REMARK 465 GLY C 4 REMARK 465 ALA C 5 REMARK 465 PRO C 6 REMARK 465 SER C 7 REMARK 465 TRP C 8 REMARK 465 GLY C 9 REMARK 465 ARG C 10 REMARK 465 ARG C 11 REMARK 465 TRP C 12 REMARK 465 PHE C 13 REMARK 465 VAL C 14 REMARK 465 VAL C 15 REMARK 465 TRP C 16 REMARK 465 ALA C 17 REMARK 465 LEU C 18 REMARK 465 LEU C 19 REMARK 465 GLY C 20 REMARK 465 LEU C 21 REMARK 465 THR C 22 REMARK 465 LEU C 23 REMARK 465 GLY C 24 REMARK 465 VAL C 25 REMARK 465 LEU C 26 REMARK 465 VAL C 27 REMARK 465 ALA C 28 REMARK 465 SER C 29 REMARK 465 ALA C 30 REMARK 465 ALA C 31 REMARK 465 PRO C 32 REMARK 465 SER C 33 REMARK 465 SER C 34 REMARK 465 PRO C 35 REMARK 465 GLY C 36 REMARK 465 THR C 37 REMARK 465 PRO C 38 REMARK 465 GLY C 39 REMARK 465 VAL C 40 REMARK 465 ALA C 41 REMARK 465 ALA C 42 REMARK 465 ALA C 43 REMARK 465 THR C 44 REMARK 465 GLN C 45 REMARK 465 ALA C 46 REMARK 465 ALA C 47 REMARK 465 ASN C 48 REMARK 465 GLY C 49 REMARK 465 GLY C 50 REMARK 465 PRO C 51 REMARK 465 ALA C 52 REMARK 465 THR C 53 REMARK 465 PRO C 54 REMARK 465 ALA C 55 REMARK 465 PRO C 56 REMARK 465 PRO C 57 REMARK 465 ALA C 58 REMARK 465 LEU C 59 REMARK 465 GLY C 60 REMARK 465 ALA C 61 REMARK 465 ALA C 62 REMARK 465 PRO C 63 REMARK 465 THR C 64 REMARK 465 GLY C 65 REMARK 465 ASP C 66 REMARK 465 PRO C 67 REMARK 465 LYS C 68 REMARK 465 PRO C 69 REMARK 465 LYS C 70 REMARK 465 LYS C 71 REMARK 465 ASN C 72 REMARK 465 LYS C 73 REMARK 465 LYS C 74 REMARK 465 PRO C 75 REMARK 465 LYS C 76 REMARK 465 ASN C 77 REMARK 465 PRO C 78 REMARK 465 THR C 79 REMARK 465 PRO C 80 REMARK 465 PRO C 81 REMARK 465 ARG C 82 REMARK 465 PRO C 83 REMARK 465 ALA C 84 REMARK 465 GLY C 85 REMARK 465 ASP C 86 REMARK 465 ASN C 87 REMARK 465 ALA C 88 REMARK 465 THR C 89 REMARK 465 LYS C 475 REMARK 465 PRO C 476 REMARK 465 PRO C 477 REMARK 465 ASN C 478 REMARK 465 PRO C 479 REMARK 465 THR C 480 REMARK 465 PRO C 481 REMARK 465 PRO C 482 REMARK 465 PRO C 483 REMARK 465 PRO C 484 REMARK 465 GLY C 485 REMARK 465 ALA C 486 REMARK 465 SER C 487 REMARK 465 ALA C 488 REMARK 465 ASN C 489 REMARK 465 ALA C 490 REMARK 465 SER C 491 REMARK 465 VAL C 492 REMARK 465 GLU C 493 REMARK 465 ARG C 494 REMARK 465 ILE C 495 REMARK 465 LYS C 496 REMARK 465 THR C 497 REMARK 465 THR C 498 REMARK 465 SER C 499 REMARK 465 SER C 500 REMARK 465 LEU C 809 REMARK 465 TYR C 810 REMARK 465 PRO C 811 REMARK 465 LEU C 812 REMARK 465 THR C 813 REMARK 465 THR C 814 REMARK 465 LYS C 815 REMARK 465 GLU C 816 REMARK 465 LEU C 817 REMARK 465 LYS C 818 REMARK 465 ASN C 819 REMARK 465 PRO C 820 REMARK 465 THR C 821 REMARK 465 ASN C 822 REMARK 465 PRO C 823 REMARK 465 ASP C 824 REMARK 465 ALA C 825 REMARK 465 SER C 826 REMARK 465 GLY C 827 REMARK 465 GLU C 828 REMARK 465 GLY C 829 REMARK 465 GLU C 830 REMARK 465 GLU C 831 REMARK 465 GLY C 832 REMARK 465 GLY C 833 REMARK 465 ASP C 834 REMARK 465 PHE C 835 REMARK 465 ASP C 836 REMARK 465 GLU C 837 REMARK 465 ALA C 838 REMARK 465 LYS C 839 REMARK 465 LEU C 840 REMARK 465 ALA C 841 REMARK 465 GLU C 842 REMARK 465 ALA C 843 REMARK 465 ARG C 844 REMARK 465 GLU C 845 REMARK 465 MET C 846 REMARK 465 ILE C 847 REMARK 465 ARG C 848 REMARK 465 TYR C 849 REMARK 465 MET C 850 REMARK 465 ALA C 851 REMARK 465 LEU C 852 REMARK 465 VAL C 853 REMARK 465 SER C 854 REMARK 465 ALA C 855 REMARK 465 MET C 856 REMARK 465 GLU C 857 REMARK 465 ARG C 858 REMARK 465 THR C 859 REMARK 465 GLU C 860 REMARK 465 HIS C 861 REMARK 465 LYS C 862 REMARK 465 ALA C 863 REMARK 465 LYS C 864 REMARK 465 LYS C 865 REMARK 465 LYS C 866 REMARK 465 GLY C 867 REMARK 465 THR C 868 REMARK 465 SER C 869 REMARK 465 ALA C 870 REMARK 465 LEU C 871 REMARK 465 LEU C 872 REMARK 465 SER C 873 REMARK 465 ALA C 874 REMARK 465 LYS C 875 REMARK 465 VAL C 876 REMARK 465 THR C 877 REMARK 465 ASP C 878 REMARK 465 MET C 879 REMARK 465 VAL C 880 REMARK 465 MET C 881 REMARK 465 ARG C 882 REMARK 465 LYS C 883 REMARK 465 ARG C 884 REMARK 465 ARG C 885 REMARK 465 ASN C 886 REMARK 465 THR C 887 REMARK 465 ASN C 888 REMARK 465 ALA C 889 REMARK 465 THR C 890 REMARK 465 GLN C 891 REMARK 465 VAL C 892 REMARK 465 PRO C 893 REMARK 465 ASN C 894 REMARK 465 LYS C 895 REMARK 465 ASP C 896 REMARK 465 GLY C 897 REMARK 465 ASP C 898 REMARK 465 ALA C 899 REMARK 465 ASP C 900 REMARK 465 GLU C 901 REMARK 465 ASP C 902 REMARK 465 ASP C 903 REMARK 465 LEU C 904 REMARK 465 GLN C 905 REMARK 465 LEU C 906 REMARK 465 GLY C 907 REMARK 465 SER C 908 REMARK 465 GLY C 909 REMARK 465 SER C 910 REMARK 465 GLY C 911 REMARK 465 THR C 912 REMARK 465 LEU C 913 REMARK 465 GLU C 914 REMARK 465 VAL C 915 REMARK 465 LEU C 916 REMARK 465 PHE C 917 REMARK 465 GLN C 918 REMARK 465 GLY C 919 REMARK 465 PRO C 920 REMARK 465 GLY C 921 REMARK 465 GLY C 922 REMARK 465 SER C 923 REMARK 465 GLY C 924 REMARK 465 SER C 925 REMARK 465 ALA C 926 REMARK 465 TRP C 927 REMARK 465 SER C 928 REMARK 465 HIS C 929 REMARK 465 PRO C 930 REMARK 465 GLN C 931 REMARK 465 PHE C 932 REMARK 465 GLU C 933 REMARK 465 LYS C 934 REMARK 465 GLY C 935 REMARK 465 GLY C 936 REMARK 465 GLY C 937 REMARK 465 SER C 938 REMARK 465 GLY C 939 REMARK 465 GLY C 940 REMARK 465 GLY C 941 REMARK 465 SER C 942 REMARK 465 GLY C 943 REMARK 465 GLY C 944 REMARK 465 SER C 945 REMARK 465 ALA C 946 REMARK 465 TRP C 947 REMARK 465 SER C 948 REMARK 465 HIS C 949 REMARK 465 PRO C 950 REMARK 465 GLN C 951 REMARK 465 PHE C 952 REMARK 465 GLU C 953 REMARK 465 LYS C 954 REMARK 465 VAL d 42 REMARK 465 GLN d 43 REMARK 465 GLY d 44 REMARK 465 LYS d 45 REMARK 465 SER d 46 REMARK 465 SER d 116 REMARK 465 SER d 117 REMARK 465 THR d 118 REMARK 465 SER d 119 REMARK 465 VAL e 42 REMARK 465 GLN e 43 REMARK 465 GLY e 44 REMARK 465 LYS e 45 REMARK 465 SER e 46 REMARK 465 SER e 116 REMARK 465 SER e 117 REMARK 465 THR e 118 REMARK 465 SER e 119 REMARK 465 VAL f 42 REMARK 465 GLN f 43 REMARK 465 GLY f 44 REMARK 465 LYS f 45 REMARK 465 SER f 46 REMARK 465 SER f 116 REMARK 465 SER f 117 REMARK 465 THR f 118 REMARK 465 SER f 119 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: COVALENT BOND ANGLES REMARK 500 REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1) REMARK 500 REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999 REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996 REMARK 500 REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3 REMARK 500 ARG A 98 NE - CZ - NH2 ANGL. DEV. = 3.6 DEGREES REMARK 500 ARG A 245 NE - CZ - NH2 ANGL. DEV. = 3.5 DEGREES REMARK 500 ARG A 258 NE - CZ - NH2 ANGL. DEV. = 3.7 DEGREES REMARK 500 ARG A 279 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG A 342 NE - CZ - NH2 ANGL. DEV. = 4.0 DEGREES REMARK 500 ARG A 418 NE - CZ - NH2 ANGL. DEV. = 3.4 DEGREES REMARK 500 ARG A 505 NE - CZ - NH2 ANGL. DEV. = 3.0 DEGREES REMARK 500 ARG A 515 NE - CZ - NH2 ANGL. DEV. = 3.0 DEGREES REMARK 500 ARG A 558 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG A 624 NE - CZ - NH2 ANGL. DEV. = 3.4 DEGREES REMARK 500 ARG A 691 NE - CZ - NH2 ANGL. DEV. = 3.4 DEGREES REMARK 500 ARG A 707 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG A 708 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG A 747 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 ARG B 98 NE - CZ - NH2 ANGL. DEV. = 3.5 DEGREES REMARK 500 ARG B 102 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG B 208 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 ARG B 245 NE - CZ - NH2 ANGL. DEV. = 3.6 DEGREES REMARK 500 ARG B 279 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG B 335 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 ARG B 418 NE - CZ - NH2 ANGL. DEV. = 3.3 DEGREES REMARK 500 ARG B 515 NE - CZ - NH2 ANGL. DEV. = 3.0 DEGREES REMARK 500 ARG B 543 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 ARG B 558 NE - CZ - NH2 ANGL. DEV. = 3.6 DEGREES REMARK 500 ARG B 624 NE - CZ - NH2 ANGL. DEV. = 3.4 DEGREES REMARK 500 ARG B 691 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG B 707 NE - CZ - NH2 ANGL. DEV. = 3.5 DEGREES REMARK 500 ARG B 708 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG C 98 NE - CZ - NH2 ANGL. DEV. = 3.6 DEGREES REMARK 500 ARG C 136 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 ARG C 189 NE - CZ - NH2 ANGL. DEV. = 3.0 DEGREES REMARK 500 ARG C 258 NE - CZ - NH2 ANGL. DEV. = 3.3 DEGREES REMARK 500 ARG C 279 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 ARG C 418 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG C 543 NE - CZ - NH2 ANGL. DEV. = 3.3 DEGREES REMARK 500 ARG C 558 NE - CZ - NH2 ANGL. DEV. = 3.3 DEGREES REMARK 500 ARG C 624 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG C 691 NE - CZ - NH2 ANGL. DEV. = 3.5 DEGREES REMARK 500 ARG C 707 NE - CZ - NH2 ANGL. DEV. = 3.3 DEGREES REMARK 500 ARG C 708 NE - CZ - NH2 ANGL. DEV. = 3.5 DEGREES REMARK 500 ARG C 747 NE - CZ - NH2 ANGL. DEV. = 3.5 DEGREES REMARK 500 ARG d 56 NE - CZ - NH2 ANGL. DEV. = 3.3 DEGREES REMARK 500 ARG d 68 NE - CZ - NH2 ANGL. DEV. = 3.9 DEGREES REMARK 500 ARG d 100 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG d 102 NE - CZ - NH2 ANGL. DEV. = 3.2 DEGREES REMARK 500 ARG e 19 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 ARG e 56 NE - CZ - NH2 ANGL. DEV. = 3.6 DEGREES REMARK 500 ARG e 68 NE - CZ - NH2 ANGL. DEV. = 4.2 DEGREES REMARK 500 CYS e 97 CA - CB - SG ANGL. DEV. = 7.0 DEGREES REMARK 500 ARG e 100 NE - CZ - NH2 ANGL. DEV. = 3.1 DEGREES REMARK 500 REMARK 500 THIS ENTRY HAS 55 ANGLE DEVIATIONS. REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LEU A 252 -38.98 -141.61 REMARK 500 CYS A 392 48.95 -82.24 REMARK 500 ARG A 428 -53.88 -127.04 REMARK 500 GLN A 507 -79.29 -26.13 REMARK 500 LEU A 564 54.73 -93.89 REMARK 500 THR A 669 -70.23 -25.23 REMARK 500 ASN A 674 16.47 58.15 REMARK 500 THR A 690 -74.43 -79.53 REMARK 500 ASN A 804 72.51 -158.04 REMARK 500 LYS B 200 -54.47 -120.61 REMARK 500 LYS B 204 -12.38 -140.99 REMARK 500 GLN B 507 -73.16 -58.33 REMARK 500 LEU B 564 57.35 -93.55 REMARK 500 SER B 656 -63.58 -109.96 REMARK 500 THR B 690 -59.55 -121.03 REMARK 500 ASN B 804 69.67 -155.81 REMARK 500 LYS C 200 -55.17 -121.15 REMARK 500 LYS C 204 -32.53 -138.80 REMARK 500 LYS C 333 85.93 -61.33 REMARK 500 LEU C 564 56.08 -92.39 REMARK 500 SER C 656 -64.32 -107.88 REMARK 500 ASN C 804 72.31 -157.54 REMARK 500 VAL d 50 -54.83 -121.63 REMARK 500 ARG d 56 -18.77 -49.46 REMARK 500 VAL e 50 -55.33 -122.97 REMARK 500 REMARK 500 REMARK: NULL REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: PLANAR GROUPS REMARK 500 REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS REMARK 500 AN RMSD GREATER THAN THIS VALUE REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 M RES CSSEQI RMS TYPE REMARK 500 ARG A 423 0.09 SIDE CHAIN REMARK 500 ARG A 599 0.12 SIDE CHAIN REMARK 500 ARG B 328 0.09 SIDE CHAIN REMARK 500 ARG B 423 0.09 SIDE CHAIN REMARK 500 ARG C 423 0.10 SIDE CHAIN REMARK 500 ARG C 599 0.11 SIDE CHAIN REMARK 500 ARG f 68 0.09 SIDE CHAIN REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 9IH8 RELATED DB: PDB REMARK 900 RELATED ID: EMD-52863 RELATED DB: EMDB REMARK 900 RELATED ID: 9Q9L RELATED DB: PDB REMARK 900 RELATED ID: EMD-52963 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-52965 RELATED DB: EMDB REMARK 900 HSV-1 PREFUSION GLYCOPROTEIN B BOUND BY NB1_GBHSV DBREF 9Q9N A 1 904 UNP A1Z0P7 A1Z0P7_HHV1 1 904 DBREF 9Q9N B 1 904 UNP A1Z0P7 A1Z0P7_HHV1 1 904 DBREF 9Q9N C 1 904 UNP A1Z0P7 A1Z0P7_HHV1 1 904 DBREF 9Q9N d 1 119 PDB 9Q9N 9Q9N 1 119 DBREF 9Q9N e 1 119 PDB 9Q9N 9Q9N 1 119 DBREF 9Q9N f 1 119 PDB 9Q9N 9Q9N 1 119 SEQADV 9Q9N CYS A 392 UNP A1Z0P7 SER 392 ENGINEERED MUTATION SEQADV 9Q9N PRO A 516 UNP A1Z0P7 HIS 516 ENGINEERED MUTATION SEQADV 9Q9N CYS A 532 UNP A1Z0P7 GLN 532 ENGINEERED MUTATION SEQADV 9Q9N VAL A 709 UNP A1Z0P7 ASN 709 ENGINEERED MUTATION SEQADV 9Q9N ALA A 889 UNP A1Z0P7 TYR 889 ENGINEERED MUTATION SEQADV 9Q9N GLN A 905 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU A 906 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 907 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 908 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 909 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 910 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 911 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N THR A 912 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU A 913 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU A 914 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N VAL A 915 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU A 916 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE A 917 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN A 918 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 919 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO A 920 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 921 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 922 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 923 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 924 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 925 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N ALA A 926 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N TRP A 927 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 928 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N HIS A 929 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO A 930 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN A 931 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE A 932 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU A 933 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LYS A 934 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 935 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 936 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 937 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 938 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 939 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 940 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 941 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 942 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 943 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY A 944 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 945 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N ALA A 946 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N TRP A 947 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER A 948 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N HIS A 949 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO A 950 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN A 951 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE A 952 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU A 953 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LYS A 954 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N CYS B 392 UNP A1Z0P7 SER 392 ENGINEERED MUTATION SEQADV 9Q9N PRO B 516 UNP A1Z0P7 HIS 516 ENGINEERED MUTATION SEQADV 9Q9N CYS B 532 UNP A1Z0P7 GLN 532 ENGINEERED MUTATION SEQADV 9Q9N VAL B 709 UNP A1Z0P7 ASN 709 ENGINEERED MUTATION SEQADV 9Q9N ALA B 889 UNP A1Z0P7 TYR 889 ENGINEERED MUTATION SEQADV 9Q9N GLN B 905 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU B 906 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 907 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 908 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 909 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 910 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 911 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N THR B 912 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU B 913 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU B 914 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N VAL B 915 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU B 916 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE B 917 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN B 918 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 919 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO B 920 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 921 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 922 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 923 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 924 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 925 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N ALA B 926 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N TRP B 927 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 928 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N HIS B 929 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO B 930 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN B 931 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE B 932 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU B 933 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LYS B 934 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 935 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 936 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 937 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 938 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 939 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 940 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 941 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 942 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 943 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY B 944 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 945 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N ALA B 946 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N TRP B 947 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER B 948 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N HIS B 949 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO B 950 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN B 951 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE B 952 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU B 953 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LYS B 954 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N CYS C 392 UNP A1Z0P7 SER 392 ENGINEERED MUTATION SEQADV 9Q9N PRO C 516 UNP A1Z0P7 HIS 516 ENGINEERED MUTATION SEQADV 9Q9N CYS C 532 UNP A1Z0P7 GLN 532 ENGINEERED MUTATION SEQADV 9Q9N VAL C 709 UNP A1Z0P7 ASN 709 ENGINEERED MUTATION SEQADV 9Q9N ALA C 889 UNP A1Z0P7 TYR 889 ENGINEERED MUTATION SEQADV 9Q9N GLN C 905 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU C 906 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 907 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 908 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 909 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 910 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 911 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N THR C 912 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU C 913 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU C 914 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N VAL C 915 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LEU C 916 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE C 917 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN C 918 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 919 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO C 920 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 921 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 922 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 923 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 924 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 925 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N ALA C 926 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N TRP C 927 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 928 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N HIS C 929 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO C 930 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN C 931 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE C 932 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU C 933 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LYS C 934 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 935 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 936 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 937 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 938 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 939 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 940 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 941 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 942 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 943 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLY C 944 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 945 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N ALA C 946 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N TRP C 947 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N SER C 948 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N HIS C 949 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PRO C 950 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLN C 951 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N PHE C 952 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N GLU C 953 UNP A1Z0P7 EXPRESSION TAG SEQADV 9Q9N LYS C 954 UNP A1Z0P7 EXPRESSION TAG SEQRES 1 A 954 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 A 954 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 A 954 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 A 954 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 A 954 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 A 954 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 A 954 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 A 954 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 A 954 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 A 954 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 A 954 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 A 954 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 A 954 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 A 954 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 A 954 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 A 954 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 A 954 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 A 954 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 A 954 LYS PRO ALA ASN ALA ALA THR ARG THR SER ARG GLY TRP SEQRES 20 A 954 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 A 954 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 A 954 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 A 954 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 A 954 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 A 954 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 A 954 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 A 954 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 A 954 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 A 954 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 A 954 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 A 954 ILE CYS THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 A 954 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 A 954 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 A 954 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 A 954 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 A 954 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 A 954 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 A 954 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 A 954 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 A 954 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 A 954 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU LEU CYS ASN SEQRES 42 A 954 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 A 954 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 A 954 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 A 954 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 A 954 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 A 954 ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY PRO SEQRES 48 A 954 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 A 954 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 A 954 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 A 954 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 A 954 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 A 954 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 A 954 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 A 954 THR GLU VAL GLN ARG ARG VAL GLN LEU HIS ASP LEU ARG SEQRES 56 A 954 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 A 954 ALA ALA MET PHE ALA GLY LEU GLY ALA PHE PHE GLU GLY SEQRES 58 A 954 MET GLY ASP LEU GLY ARG ALA VAL GLY LYS VAL VAL MET SEQRES 59 A 954 GLY ILE VAL GLY GLY VAL VAL SER ALA VAL SER GLY VAL SEQRES 60 A 954 SER SER PHE MET SER ASN PRO PHE GLY ALA LEU ALA VAL SEQRES 61 A 954 GLY LEU LEU VAL LEU ALA GLY LEU ALA ALA ALA PHE PHE SEQRES 62 A 954 ALA PHE ARG TYR VAL MET ARG LEU GLN SER ASN PRO MET SEQRES 63 A 954 LYS ALA LEU TYR PRO LEU THR THR LYS GLU LEU LYS ASN SEQRES 64 A 954 PRO THR ASN PRO ASP ALA SER GLY GLU GLY GLU GLU GLY SEQRES 65 A 954 GLY ASP PHE ASP GLU ALA LYS LEU ALA GLU ALA ARG GLU SEQRES 66 A 954 MET ILE ARG TYR MET ALA LEU VAL SER ALA MET GLU ARG SEQRES 67 A 954 THR GLU HIS LYS ALA LYS LYS LYS GLY THR SER ALA LEU SEQRES 68 A 954 LEU SER ALA LYS VAL THR ASP MET VAL MET ARG LYS ARG SEQRES 69 A 954 ARG ASN THR ASN ALA THR GLN VAL PRO ASN LYS ASP GLY SEQRES 70 A 954 ASP ALA ASP GLU ASP ASP LEU GLN LEU GLY SER GLY SER SEQRES 71 A 954 GLY THR LEU GLU VAL LEU PHE GLN GLY PRO GLY GLY SER SEQRES 72 A 954 GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SEQRES 73 A 954 GLY SER GLY GLY GLY SER GLY GLY SER ALA TRP SER HIS SEQRES 74 A 954 PRO GLN PHE GLU LYS SEQRES 1 B 954 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 B 954 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 B 954 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 B 954 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 B 954 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 B 954 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 B 954 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 B 954 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 B 954 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 B 954 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 B 954 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 B 954 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 B 954 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 B 954 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 B 954 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 B 954 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 B 954 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 B 954 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 B 954 LYS PRO ALA ASN ALA ALA THR ARG THR SER ARG GLY TRP SEQRES 20 B 954 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 B 954 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 B 954 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 B 954 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 B 954 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 B 954 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 B 954 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 B 954 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 B 954 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 B 954 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 B 954 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 B 954 ILE CYS THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 B 954 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 B 954 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 B 954 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 B 954 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 B 954 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 B 954 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 B 954 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 B 954 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 B 954 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 B 954 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU LEU CYS ASN SEQRES 42 B 954 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 B 954 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 B 954 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 B 954 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 B 954 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 B 954 ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY PRO SEQRES 48 B 954 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 B 954 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 B 954 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 B 954 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 B 954 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 B 954 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 B 954 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 B 954 THR GLU VAL GLN ARG ARG VAL GLN LEU HIS ASP LEU ARG SEQRES 56 B 954 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 B 954 ALA ALA MET PHE ALA GLY LEU GLY ALA PHE PHE GLU GLY SEQRES 58 B 954 MET GLY ASP LEU GLY ARG ALA VAL GLY LYS VAL VAL MET SEQRES 59 B 954 GLY ILE VAL GLY GLY VAL VAL SER ALA VAL SER GLY VAL SEQRES 60 B 954 SER SER PHE MET SER ASN PRO PHE GLY ALA LEU ALA VAL SEQRES 61 B 954 GLY LEU LEU VAL LEU ALA GLY LEU ALA ALA ALA PHE PHE SEQRES 62 B 954 ALA PHE ARG TYR VAL MET ARG LEU GLN SER ASN PRO MET SEQRES 63 B 954 LYS ALA LEU TYR PRO LEU THR THR LYS GLU LEU LYS ASN SEQRES 64 B 954 PRO THR ASN PRO ASP ALA SER GLY GLU GLY GLU GLU GLY SEQRES 65 B 954 GLY ASP PHE ASP GLU ALA LYS LEU ALA GLU ALA ARG GLU SEQRES 66 B 954 MET ILE ARG TYR MET ALA LEU VAL SER ALA MET GLU ARG SEQRES 67 B 954 THR GLU HIS LYS ALA LYS LYS LYS GLY THR SER ALA LEU SEQRES 68 B 954 LEU SER ALA LYS VAL THR ASP MET VAL MET ARG LYS ARG SEQRES 69 B 954 ARG ASN THR ASN ALA THR GLN VAL PRO ASN LYS ASP GLY SEQRES 70 B 954 ASP ALA ASP GLU ASP ASP LEU GLN LEU GLY SER GLY SER SEQRES 71 B 954 GLY THR LEU GLU VAL LEU PHE GLN GLY PRO GLY GLY SER SEQRES 72 B 954 GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SEQRES 73 B 954 GLY SER GLY GLY GLY SER GLY GLY SER ALA TRP SER HIS SEQRES 74 B 954 PRO GLN PHE GLU LYS SEQRES 1 C 954 MET HIS GLN GLY ALA PRO SER TRP GLY ARG ARG TRP PHE SEQRES 2 C 954 VAL VAL TRP ALA LEU LEU GLY LEU THR LEU GLY VAL LEU SEQRES 3 C 954 VAL ALA SER ALA ALA PRO SER SER PRO GLY THR PRO GLY SEQRES 4 C 954 VAL ALA ALA ALA THR GLN ALA ALA ASN GLY GLY PRO ALA SEQRES 5 C 954 THR PRO ALA PRO PRO ALA LEU GLY ALA ALA PRO THR GLY SEQRES 6 C 954 ASP PRO LYS PRO LYS LYS ASN LYS LYS PRO LYS ASN PRO SEQRES 7 C 954 THR PRO PRO ARG PRO ALA GLY ASP ASN ALA THR VAL ALA SEQRES 8 C 954 ALA GLY HIS ALA THR LEU ARG GLU HIS LEU ARG ASP ILE SEQRES 9 C 954 LYS ALA GLU ASN THR ASP ALA ASN PHE TYR VAL CYS PRO SEQRES 10 C 954 PRO PRO THR GLY ALA THR VAL VAL GLN PHE GLU GLN PRO SEQRES 11 C 954 ARG ARG CYS PRO THR ARG PRO GLU GLY GLN ASN TYR THR SEQRES 12 C 954 GLU GLY ILE ALA VAL VAL PHE LYS GLU ASN ILE ALA PRO SEQRES 13 C 954 TYR LYS PHE LYS ALA THR MET TYR TYR LYS ASP VAL THR SEQRES 14 C 954 VAL SER GLN VAL TRP PHE GLY HIS ARG TYR SER GLN PHE SEQRES 15 C 954 MET GLY ILE PHE GLU ASP ARG ALA PRO VAL PRO PHE GLU SEQRES 16 C 954 GLU VAL ILE ASP LYS ILE ASN ALA LYS GLY VAL CYS ARG SEQRES 17 C 954 SER THR ALA LYS TYR VAL ARG ASN ASN LEU GLU THR THR SEQRES 18 C 954 ALA PHE HIS ARG ASP ASP HIS GLU THR ASP MET GLU LEU SEQRES 19 C 954 LYS PRO ALA ASN ALA ALA THR ARG THR SER ARG GLY TRP SEQRES 20 C 954 HIS THR THR ASP LEU LYS TYR ASN PRO SER ARG VAL GLU SEQRES 21 C 954 ALA PHE HIS ARG TYR GLY THR THR VAL ASN CYS ILE VAL SEQRES 22 C 954 GLU GLU VAL ASP ALA ARG SER VAL TYR PRO TYR ASP GLU SEQRES 23 C 954 PHE VAL LEU ALA THR GLY ASP PHE VAL TYR MET SER PRO SEQRES 24 C 954 PHE TYR GLY TYR ARG GLU GLY SER HIS THR GLU HIS THR SEQRES 25 C 954 SER TYR ALA ALA ASP ARG PHE LYS GLN VAL ASP GLY PHE SEQRES 26 C 954 TYR ALA ARG ASP LEU THR THR LYS ALA ARG ALA THR ALA SEQRES 27 C 954 PRO THR THR ARG ASN LEU LEU THR THR PRO LYS PHE THR SEQRES 28 C 954 VAL ALA TRP ASP TRP VAL PRO LYS ARG PRO SER VAL CYS SEQRES 29 C 954 THR MET THR LYS TRP GLN GLU VAL ASP GLU MET LEU ARG SEQRES 30 C 954 SER GLU TYR GLY GLY SER PHE ARG PHE SER SER ASP ALA SEQRES 31 C 954 ILE CYS THR THR PHE THR THR ASN LEU THR GLU TYR PRO SEQRES 32 C 954 LEU SER ARG VAL ASP LEU GLY ASP CYS ILE GLY LYS ASP SEQRES 33 C 954 ALA ARG ASP ALA MET ASP ARG ILE PHE ALA ARG ARG TYR SEQRES 34 C 954 ASN ALA THR HIS ILE LYS VAL GLY GLN PRO GLN TYR TYR SEQRES 35 C 954 LEU ALA ASN GLY GLY PHE LEU ILE ALA TYR GLN PRO LEU SEQRES 36 C 954 LEU SER ASN THR LEU ALA GLU LEU TYR VAL ARG GLU HIS SEQRES 37 C 954 LEU ARG GLU GLN SER ARG LYS PRO PRO ASN PRO THR PRO SEQRES 38 C 954 PRO PRO PRO GLY ALA SER ALA ASN ALA SER VAL GLU ARG SEQRES 39 C 954 ILE LYS THR THR SER SER ILE GLU PHE ALA ARG LEU GLN SEQRES 40 C 954 PHE THR TYR ASN HIS ILE GLN ARG PRO VAL ASN ASP MET SEQRES 41 C 954 LEU GLY ARG VAL ALA ILE ALA TRP CYS GLU LEU CYS ASN SEQRES 42 C 954 HIS GLU LEU THR LEU TRP ASN GLU ALA ARG LYS LEU ASN SEQRES 43 C 954 PRO ASN ALA ILE ALA SER VAL THR VAL GLY ARG ARG VAL SEQRES 44 C 954 SER ALA ARG MET LEU GLY ASP VAL MET ALA VAL SER THR SEQRES 45 C 954 CYS VAL PRO VAL ALA ALA ASP ASN VAL ILE VAL GLN ASN SEQRES 46 C 954 SER MET ARG ILE SER SER ARG PRO GLY ALA CYS TYR SER SEQRES 47 C 954 ARG PRO LEU VAL SER PHE ARG TYR GLU ASP GLN GLY PRO SEQRES 48 C 954 LEU VAL GLU GLY GLN LEU GLY GLU ASN ASN GLU LEU ARG SEQRES 49 C 954 LEU THR ARG ASP ALA ILE GLU PRO CYS THR VAL GLY HIS SEQRES 50 C 954 ARG ARG TYR PHE THR PHE GLY GLY GLY TYR VAL TYR PHE SEQRES 51 C 954 GLU GLU TYR ALA TYR SER HIS GLN LEU SER ARG ALA ASP SEQRES 52 C 954 ILE THR THR VAL SER THR PHE ILE ASP LEU ASN ILE THR SEQRES 53 C 954 MET LEU GLU ASP HIS GLU PHE VAL PRO LEU GLU VAL TYR SEQRES 54 C 954 THR ARG HIS GLU ILE LYS ASP SER GLY LEU LEU ASP TYR SEQRES 55 C 954 THR GLU VAL GLN ARG ARG VAL GLN LEU HIS ASP LEU ARG SEQRES 56 C 954 PHE ALA ASP ILE ASP THR VAL ILE HIS ALA ASP ALA ASN SEQRES 57 C 954 ALA ALA MET PHE ALA GLY LEU GLY ALA PHE PHE GLU GLY SEQRES 58 C 954 MET GLY ASP LEU GLY ARG ALA VAL GLY LYS VAL VAL MET SEQRES 59 C 954 GLY ILE VAL GLY GLY VAL VAL SER ALA VAL SER GLY VAL SEQRES 60 C 954 SER SER PHE MET SER ASN PRO PHE GLY ALA LEU ALA VAL SEQRES 61 C 954 GLY LEU LEU VAL LEU ALA GLY LEU ALA ALA ALA PHE PHE SEQRES 62 C 954 ALA PHE ARG TYR VAL MET ARG LEU GLN SER ASN PRO MET SEQRES 63 C 954 LYS ALA LEU TYR PRO LEU THR THR LYS GLU LEU LYS ASN SEQRES 64 C 954 PRO THR ASN PRO ASP ALA SER GLY GLU GLY GLU GLU GLY SEQRES 65 C 954 GLY ASP PHE ASP GLU ALA LYS LEU ALA GLU ALA ARG GLU SEQRES 66 C 954 MET ILE ARG TYR MET ALA LEU VAL SER ALA MET GLU ARG SEQRES 67 C 954 THR GLU HIS LYS ALA LYS LYS LYS GLY THR SER ALA LEU SEQRES 68 C 954 LEU SER ALA LYS VAL THR ASP MET VAL MET ARG LYS ARG SEQRES 69 C 954 ARG ASN THR ASN ALA THR GLN VAL PRO ASN LYS ASP GLY SEQRES 70 C 954 ASP ALA ASP GLU ASP ASP LEU GLN LEU GLY SER GLY SER SEQRES 71 C 954 GLY THR LEU GLU VAL LEU PHE GLN GLY PRO GLY GLY SER SEQRES 72 C 954 GLY SER ALA TRP SER HIS PRO GLN PHE GLU LYS GLY GLY SEQRES 73 C 954 GLY SER GLY GLY GLY SER GLY GLY SER ALA TRP SER HIS SEQRES 74 C 954 PRO GLN PHE GLU LYS SEQRES 1 d 119 GLN VAL GLN LEU VAL GLU SER GLY GLY GLY SER VAL GLN SEQRES 2 d 119 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER ALA SEQRES 3 d 119 SER GLY ARG LEU SER MET SER GLY ALA LEU GLY TRP TYR SEQRES 4 d 119 ARG GLN VAL GLN GLY LYS SER ARG GLU LEU VAL ALA THR SEQRES 5 d 119 ILE THR ASP ARG SER SER THR ASN TYR ALA ASP SER VAL SEQRES 6 d 119 LYS GLY ARG PHE THR ILE SER ILE ASP ASP ALA GLU ASN SEQRES 7 d 119 THR MET TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP SEQRES 8 d 119 THR GLY VAL TYR TYR CYS ASN ALA ARG TRP ARG GLY MET SEQRES 9 d 119 ASN VAL TRP GLY LYS GLY THR ARG VAL THR VAL SER SER SEQRES 10 d 119 THR SER SEQRES 1 e 119 GLN VAL GLN LEU VAL GLU SER GLY GLY GLY SER VAL GLN SEQRES 2 e 119 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER ALA SEQRES 3 e 119 SER GLY ARG LEU SER MET SER GLY ALA LEU GLY TRP TYR SEQRES 4 e 119 ARG GLN VAL GLN GLY LYS SER ARG GLU LEU VAL ALA THR SEQRES 5 e 119 ILE THR ASP ARG SER SER THR ASN TYR ALA ASP SER VAL SEQRES 6 e 119 LYS GLY ARG PHE THR ILE SER ILE ASP ASP ALA GLU ASN SEQRES 7 e 119 THR MET TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP SEQRES 8 e 119 THR GLY VAL TYR TYR CYS ASN ALA ARG TRP ARG GLY MET SEQRES 9 e 119 ASN VAL TRP GLY LYS GLY THR ARG VAL THR VAL SER SER SEQRES 10 e 119 THR SER SEQRES 1 f 119 GLN VAL GLN LEU VAL GLU SER GLY GLY GLY SER VAL GLN SEQRES 2 f 119 PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER ALA SEQRES 3 f 119 SER GLY ARG LEU SER MET SER GLY ALA LEU GLY TRP TYR SEQRES 4 f 119 ARG GLN VAL GLN GLY LYS SER ARG GLU LEU VAL ALA THR SEQRES 5 f 119 ILE THR ASP ARG SER SER THR ASN TYR ALA ASP SER VAL SEQRES 6 f 119 LYS GLY ARG PHE THR ILE SER ILE ASP ASP ALA GLU ASN SEQRES 7 f 119 THR MET TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP SEQRES 8 f 119 THR GLY VAL TYR TYR CYS ASN ALA ARG TRP ARG GLY MET SEQRES 9 f 119 ASN VAL TRP GLY LYS GLY THR ARG VAL THR VAL SER SER SEQRES 10 f 119 THR SER HET NAG D 1 14 HET NAG D 2 14 HET NAG E 1 14 HET NAG E 2 14 HET NAG F 1 14 HET NAG F 2 14 HET NAG G 1 14 HET NAG G 2 14 HET NAG H 1 14 HET NAG H 2 14 HET NAG I 1 14 HET NAG I 2 14 HET NAG J 1 14 HET NAG J 2 14 HET NAG K 1 14 HET NAG K 2 14 HET NAG L 1 14 HET NAG L 2 14 HET NAG M 1 14 HET NAG M 2 14 HET NAG N 1 14 HET NAG N 2 14 HET NAG O 1 14 HET NAG O 2 14 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE FORMUL 7 NAG 24(C8 H15 N O6) HELIX 1 AA1 ALA A 91 GLU A 107 1 17 HELIX 2 AA2 GLN A 172 PHE A 175 5 4 HELIX 3 AA3 GLY A 176 GLN A 181 1 6 HELIX 4 AA4 PHE A 182 GLY A 184 5 3 HELIX 5 AA5 PRO A 193 LYS A 200 1 8 HELIX 6 AA6 LYS A 200 GLY A 205 1 6 HELIX 7 AA7 ARG A 225 ASP A 227 5 3 HELIX 8 AA8 SER A 257 HIS A 263 1 7 HELIX 9 AA9 ALA A 315 ASP A 317 5 3 HELIX 10 AB1 PRO A 403 VAL A 407 5 5 HELIX 11 AB2 ILE A 413 ARG A 428 1 16 HELIX 12 AB3 TYR A 429 ALA A 431 5 3 HELIX 13 AB4 ASN A 458 SER A 473 1 16 HELIX 14 AB5 GLU A 502 GLN A 507 1 6 HELIX 15 AB6 TYR A 510 ASN A 546 1 37 HELIX 16 AB7 ASN A 546 GLY A 556 1 11 HELIX 17 AB8 ALA A 577 ASP A 579 5 3 HELIX 18 AB9 ALA A 662 ILE A 664 5 3 HELIX 19 AC1 PRO A 685 TYR A 689 5 5 HELIX 20 AC2 ASP A 701 ALA A 725 1 25 HELIX 21 AC3 ASP A 726 GLY A 741 1 16 HELIX 22 AC4 MET A 742 ASN A 773 1 32 HELIX 23 AC5 ASN A 773 SER A 803 1 31 HELIX 24 AC6 ALA B 91 LYS B 105 1 15 HELIX 25 AC7 VAL B 173 PHE B 175 5 3 HELIX 26 AC8 GLY B 176 GLN B 181 1 6 HELIX 27 AC9 PRO B 193 LYS B 200 1 8 HELIX 28 AD1 LYS B 200 GLY B 205 1 6 HELIX 29 AD2 ARG B 225 ASP B 227 5 3 HELIX 30 AD3 ASP B 251 ASN B 255 5 5 HELIX 31 AD4 SER B 257 ARG B 264 1 8 HELIX 32 AD5 ALA B 315 ASP B 317 5 3 HELIX 33 AD6 PRO B 403 VAL B 407 5 5 HELIX 34 AD7 ASP B 411 TYR B 429 1 19 HELIX 35 AD8 ASN B 458 ARG B 474 1 17 HELIX 36 AD9 GLU B 502 GLN B 507 1 6 HELIX 37 AE1 TYR B 510 ASN B 546 1 37 HELIX 38 AE2 ASN B 546 GLY B 556 1 11 HELIX 39 AE3 ALA B 577 ASP B 579 5 3 HELIX 40 AE4 ALA B 662 ILE B 664 5 3 HELIX 41 AE5 PRO B 685 THR B 690 5 6 HELIX 42 AE6 ASP B 701 ALA B 725 1 25 HELIX 43 AE7 ASP B 726 GLY B 741 1 16 HELIX 44 AE8 MET B 742 ASN B 773 1 32 HELIX 45 AE9 ASN B 773 SER B 803 1 31 HELIX 46 AF1 ALA C 91 ALA C 106 1 16 HELIX 47 AF2 VAL C 173 PHE C 175 5 3 HELIX 48 AF3 GLY C 176 GLN C 181 1 6 HELIX 49 AF4 PRO C 193 LYS C 200 1 8 HELIX 50 AF5 ARG C 225 ASP C 227 5 3 HELIX 51 AF6 SER C 257 ARG C 264 1 8 HELIX 52 AF7 ALA C 315 ASP C 317 5 3 HELIX 53 AF8 PRO C 403 VAL C 407 5 5 HELIX 54 AF9 ASP C 411 TYR C 429 1 19 HELIX 55 AG1 ASN C 458 SER C 473 1 16 HELIX 56 AG2 GLU C 502 GLN C 507 1 6 HELIX 57 AG3 TYR C 510 ASN C 546 1 37 HELIX 58 AG4 ASN C 546 GLY C 556 1 11 HELIX 59 AG5 ALA C 577 ASP C 579 5 3 HELIX 60 AG6 ALA C 662 ILE C 664 5 3 HELIX 61 AG7 LEU C 686 HIS C 692 1 7 HELIX 62 AG8 ASP C 701 ALA C 725 1 25 HELIX 63 AG9 ASP C 726 GLY C 743 1 18 HELIX 64 AH1 GLY C 743 SER C 772 1 30 HELIX 65 AH2 ASN C 773 SER C 803 1 31 HELIX 66 AH3 ARG d 29 SER d 33 5 5 HELIX 67 AH4 LYS d 88 THR d 92 5 5 HELIX 68 AH5 ARG e 29 SER e 33 5 5 HELIX 69 AH6 LYS e 88 THR e 92 5 5 HELIX 70 AH7 ARG f 29 SER f 33 5 5 HELIX 71 AH8 LYS f 88 THR f 92 5 5 SHEET 1 AA1 6 VAL A 574 VAL A 576 0 SHEET 2 AA1 6 PHE A 113 VAL A 115 -1 N PHE A 113 O VAL A 576 SHEET 3 AA1 6 GLU A 622 ARG A 624 1 O LEU A 623 N TYR A 114 SHEET 4 AA1 6 VAL A 613 LEU A 617 -1 N GLN A 616 O ARG A 624 SHEET 5 AA1 6 LEU A 601 PHE A 604 -1 N PHE A 604 O VAL A 613 SHEET 6 AA1 6 VAL A 581 VAL A 583 -1 N ILE A 582 O SER A 603 SHEET 1 AA2 4 VAL A 559 MET A 563 0 SHEET 2 AA2 4 MET A 568 THR A 572 -1 O ALA A 569 N ARG A 562 SHEET 3 AA2 4 VAL A 124 GLN A 126 -1 N VAL A 125 O MET A 568 SHEET 4 AA2 4 THR B 665 THR B 666 1 O THR B 665 N GLN A 126 SHEET 1 AA3 4 MET A 366 VAL A 372 0 SHEET 2 AA3 4 GLN A 140 GLU A 152 -1 N VAL A 149 O TRP A 369 SHEET 3 AA3 4 PHE A 448 SER A 457 -1 O LEU A 449 N PHE A 150 SHEET 4 AA3 4 HIS A 433 LYS A 435 -1 N ILE A 434 O LEU A 456 SHEET 1 AA4 6 PHE A 395 ASN A 398 0 SHEET 2 AA4 6 SER A 383 SER A 387 -1 N PHE A 384 O THR A 397 SHEET 3 AA4 6 LEU A 376 TYR A 380 -1 N TYR A 380 O SER A 383 SHEET 4 AA4 6 GLN A 140 GLU A 152 -1 N GLN A 140 O GLU A 379 SHEET 5 AA4 6 PHE A 448 SER A 457 -1 O LEU A 449 N PHE A 150 SHEET 6 AA4 6 GLN A 440 ALA A 444 -1 N GLN A 440 O TYR A 452 SHEET 1 AA5 5 PHE A 186 PRO A 191 0 SHEET 2 AA5 5 TYR A 157 VAL A 170 -1 N VAL A 168 O ASP A 188 SHEET 3 AA5 5 THR A 267 SER A 280 -1 O VAL A 276 N ALA A 161 SHEET 4 AA5 5 PHE A 287 LEU A 289 -1 O VAL A 288 N ARG A 279 SHEET 5 AA5 5 PHE A 294 VAL A 295 -1 O VAL A 295 N PHE A 287 SHEET 1 AA6 7 LYS A 235 PRO A 236 0 SHEET 2 AA6 7 GLY A 246 HIS A 248 -1 O HIS A 248 N LYS A 235 SHEET 3 AA6 7 THR A 267 SER A 280 -1 O VAL A 273 N TRP A 247 SHEET 4 AA6 7 TYR A 157 VAL A 170 -1 N ALA A 161 O VAL A 276 SHEET 5 AA6 7 PHE A 350 ASP A 355 -1 O ALA A 353 N THR A 162 SHEET 6 AA6 7 THR A 340 THR A 347 -1 N LEU A 345 O VAL A 352 SHEET 7 AA6 7 PHE A 319 PHE A 325 -1 N VAL A 322 O ARG A 342 SHEET 1 AA7 2 VAL A 206 CYS A 207 0 SHEET 2 AA7 2 MET A 232 GLU A 233 -1 O MET A 232 N CYS A 207 SHEET 1 AA8 2 THR A 210 ARG A 215 0 SHEET 2 AA8 2 LEU A 218 PHE A 223 -1 O THR A 220 N TYR A 213 SHEET 1 AA9 2 ALA A 595 TYR A 597 0 SHEET 2 AA9 2 ILE A 630 PRO A 632 -1 O GLU A 631 N CYS A 596 SHEET 1 AB1 3 ARG A 638 THR A 642 0 SHEET 2 AB1 3 GLY A 646 GLU A 651 -1 O PHE A 650 N ARG A 639 SHEET 3 AB1 3 ALA A 654 SER A 660 -1 O HIS A 657 N TYR A 649 SHEET 1 AB2 4 THR A 665 THR A 666 0 SHEET 2 AB2 4 VAL C 124 GLN C 126 1 O GLN C 126 N THR A 665 SHEET 3 AB2 4 MET C 568 THR C 572 -1 O MET C 568 N VAL C 125 SHEET 4 AB2 4 VAL C 559 MET C 563 -1 N ARG C 562 O ALA C 569 SHEET 1 AB3 6 VAL B 574 VAL B 576 0 SHEET 2 AB3 6 PHE B 113 VAL B 115 -1 N PHE B 113 O VAL B 576 SHEET 3 AB3 6 GLU B 622 ARG B 624 1 O LEU B 623 N TYR B 114 SHEET 4 AB3 6 VAL B 613 LEU B 617 -1 N GLN B 616 O ARG B 624 SHEET 5 AB3 6 LEU B 601 PHE B 604 -1 N PHE B 604 O VAL B 613 SHEET 6 AB3 6 VAL B 581 VAL B 583 -1 N ILE B 582 O SER B 603 SHEET 1 AB4 4 VAL B 559 MET B 563 0 SHEET 2 AB4 4 MET B 568 THR B 572 -1 O ALA B 569 N ARG B 562 SHEET 3 AB4 4 VAL B 124 PHE B 127 -1 N VAL B 125 O MET B 568 SHEET 4 AB4 4 THR C 665 VAL C 667 1 O VAL C 667 N GLN B 126 SHEET 1 AB5 4 MET B 366 VAL B 372 0 SHEET 2 AB5 4 GLN B 140 GLU B 152 -1 N ALA B 147 O VAL B 372 SHEET 3 AB5 4 PHE B 448 SER B 457 -1 O LEU B 455 N GLU B 144 SHEET 4 AB5 4 HIS B 433 LYS B 435 -1 N ILE B 434 O LEU B 456 SHEET 1 AB6 6 PHE B 395 ASN B 398 0 SHEET 2 AB6 6 SER B 383 SER B 387 -1 N PHE B 384 O THR B 397 SHEET 3 AB6 6 LEU B 376 TYR B 380 -1 N TYR B 380 O SER B 383 SHEET 4 AB6 6 GLN B 140 GLU B 152 -1 N GLN B 140 O GLU B 379 SHEET 5 AB6 6 PHE B 448 SER B 457 -1 O LEU B 455 N GLU B 144 SHEET 6 AB6 6 GLN B 440 ALA B 444 -1 N GLN B 440 O TYR B 452 SHEET 1 AB7 5 ILE B 185 PRO B 191 0 SHEET 2 AB7 5 TYR B 157 SER B 171 -1 N VAL B 168 O ASP B 188 SHEET 3 AB7 5 THR B 267 SER B 280 -1 O SER B 280 N TYR B 157 SHEET 4 AB7 5 PHE B 287 LEU B 289 -1 O VAL B 288 N ARG B 279 SHEET 5 AB7 5 PHE B 294 VAL B 295 -1 O VAL B 295 N PHE B 287 SHEET 1 AB8 7 LYS B 235 PRO B 236 0 SHEET 2 AB8 7 GLY B 246 HIS B 248 -1 O HIS B 248 N LYS B 235 SHEET 3 AB8 7 THR B 267 SER B 280 -1 O VAL B 273 N TRP B 247 SHEET 4 AB8 7 TYR B 157 SER B 171 -1 N TYR B 157 O SER B 280 SHEET 5 AB8 7 THR B 351 ASP B 355 -1 O THR B 351 N TYR B 164 SHEET 6 AB8 7 THR B 340 THR B 346 -1 N LEU B 345 O VAL B 352 SHEET 7 AB8 7 PHE B 319 PHE B 325 -1 N VAL B 322 O ARG B 342 SHEET 1 AB9 2 VAL B 206 CYS B 207 0 SHEET 2 AB9 2 MET B 232 GLU B 233 -1 O MET B 232 N CYS B 207 SHEET 1 AC1 2 THR B 210 ARG B 215 0 SHEET 2 AC1 2 LEU B 218 PHE B 223 -1 O THR B 220 N TYR B 213 SHEET 1 AC2 2 ALA B 595 TYR B 597 0 SHEET 2 AC2 2 ILE B 630 PRO B 632 -1 O GLU B 631 N CYS B 596 SHEET 1 AC3 3 ARG B 638 THR B 642 0 SHEET 2 AC3 3 GLY B 646 GLU B 651 -1 O PHE B 650 N ARG B 639 SHEET 3 AC3 3 ALA B 654 SER B 660 -1 O HIS B 657 N TYR B 649 SHEET 1 AC4 6 VAL C 574 VAL C 576 0 SHEET 2 AC4 6 PHE C 113 VAL C 115 -1 N PHE C 113 O VAL C 576 SHEET 3 AC4 6 GLU C 622 ARG C 624 1 O LEU C 623 N TYR C 114 SHEET 4 AC4 6 VAL C 613 LEU C 617 -1 N GLN C 616 O ARG C 624 SHEET 5 AC4 6 LEU C 601 PHE C 604 -1 N PHE C 604 O VAL C 613 SHEET 6 AC4 6 VAL C 581 VAL C 583 -1 N ILE C 582 O SER C 603 SHEET 1 AC5 4 MET C 366 VAL C 372 0 SHEET 2 AC5 4 GLN C 140 GLU C 152 -1 N ALA C 147 O VAL C 372 SHEET 3 AC5 4 PHE C 448 SER C 457 -1 O LEU C 449 N PHE C 150 SHEET 4 AC5 4 HIS C 433 LYS C 435 -1 N ILE C 434 O LEU C 456 SHEET 1 AC6 6 PHE C 395 ASN C 398 0 SHEET 2 AC6 6 SER C 383 SER C 387 -1 N PHE C 384 O THR C 397 SHEET 3 AC6 6 LEU C 376 TYR C 380 -1 N TYR C 380 O SER C 383 SHEET 4 AC6 6 GLN C 140 GLU C 152 -1 N GLN C 140 O GLU C 379 SHEET 5 AC6 6 PHE C 448 SER C 457 -1 O LEU C 449 N PHE C 150 SHEET 6 AC6 6 GLN C 440 ALA C 444 -1 N GLN C 440 O TYR C 452 SHEET 1 AC7 5 ILE C 185 PRO C 191 0 SHEET 2 AC7 5 TYR C 157 SER C 171 -1 N VAL C 168 O ASP C 188 SHEET 3 AC7 5 THR C 267 SER C 280 -1 O ILE C 272 N TYR C 165 SHEET 4 AC7 5 PHE C 287 LEU C 289 -1 O VAL C 288 N ARG C 279 SHEET 5 AC7 5 PHE C 294 VAL C 295 -1 O VAL C 295 N PHE C 287 SHEET 1 AC8 7 LYS C 235 PRO C 236 0 SHEET 2 AC8 7 GLY C 246 HIS C 248 -1 O HIS C 248 N LYS C 235 SHEET 3 AC8 7 THR C 267 SER C 280 -1 O VAL C 273 N TRP C 247 SHEET 4 AC8 7 TYR C 157 SER C 171 -1 N TYR C 165 O ILE C 272 SHEET 5 AC8 7 THR C 351 ASP C 355 -1 O THR C 351 N TYR C 164 SHEET 6 AC8 7 THR C 340 THR C 346 -1 N LEU C 345 O VAL C 352 SHEET 7 AC8 7 PHE C 319 PHE C 325 -1 N VAL C 322 O ARG C 342 SHEET 1 AC9 2 VAL C 206 CYS C 207 0 SHEET 2 AC9 2 MET C 232 GLU C 233 -1 O MET C 232 N CYS C 207 SHEET 1 AD1 2 THR C 210 ARG C 215 0 SHEET 2 AD1 2 LEU C 218 PHE C 223 -1 O ALA C 222 N ALA C 211 SHEET 1 AD2 2 ALA C 595 TYR C 597 0 SHEET 2 AD2 2 ILE C 630 PRO C 632 -1 O GLU C 631 N CYS C 596 SHEET 1 AD3 3 ARG C 638 THR C 642 0 SHEET 2 AD3 3 GLY C 646 GLU C 651 -1 O PHE C 650 N ARG C 639 SHEET 3 AD3 3 ALA C 654 SER C 660 -1 O HIS C 657 N TYR C 649 SHEET 1 AD4 4 LEU d 4 SER d 7 0 SHEET 2 AD4 4 LEU d 18 ALA d 24 -1 O ALA d 23 N VAL d 5 SHEET 3 AD4 4 THR d 79 MET d 84 -1 O MET d 84 N LEU d 18 SHEET 4 AD4 4 PHE d 69 ASP d 74 -1 N THR d 70 O GLN d 83 SHEET 1 AD5 6 GLY d 10 SER d 11 0 SHEET 2 AD5 6 THR d 111 THR d 114 1 O THR d 114 N GLY d 10 SHEET 3 AD5 6 GLY d 93 TRP d 101 -1 N TYR d 95 O THR d 111 SHEET 4 AD5 6 ALA d 35 ARG d 40 -1 N TYR d 39 O TYR d 96 SHEET 5 AD5 6 GLU d 48 ASP d 55 -1 O GLU d 48 N ARG d 40 SHEET 6 AD5 6 SER d 58 TYR d 61 -1 O ASN d 60 N THR d 52 SHEET 1 AD6 4 GLY d 10 SER d 11 0 SHEET 2 AD6 4 THR d 111 THR d 114 1 O THR d 114 N GLY d 10 SHEET 3 AD6 4 GLY d 93 TRP d 101 -1 N TYR d 95 O THR d 111 SHEET 4 AD6 4 MET d 104 TRP d 107 -1 O MET d 104 N TRP d 101 SHEET 1 AD7 4 LEU e 4 SER e 7 0 SHEET 2 AD7 4 LEU e 18 ALA e 24 -1 O ALA e 23 N VAL e 5 SHEET 3 AD7 4 THR e 79 MET e 84 -1 O MET e 84 N LEU e 18 SHEET 4 AD7 4 PHE e 69 ASP e 74 -1 N THR e 70 O GLN e 83 SHEET 1 AD8 6 GLY e 10 SER e 11 0 SHEET 2 AD8 6 THR e 111 THR e 114 1 O THR e 114 N GLY e 10 SHEET 3 AD8 6 GLY e 93 TRP e 101 -1 N TYR e 95 O THR e 111 SHEET 4 AD8 6 ALA e 35 ARG e 40 -1 N TYR e 39 O TYR e 96 SHEET 5 AD8 6 GLU e 48 ASP e 55 -1 O GLU e 48 N ARG e 40 SHEET 6 AD8 6 SER e 58 TYR e 61 -1 O ASN e 60 N THR e 52 SHEET 1 AD9 4 GLY e 10 SER e 11 0 SHEET 2 AD9 4 THR e 111 THR e 114 1 O THR e 114 N GLY e 10 SHEET 3 AD9 4 GLY e 93 TRP e 101 -1 N TYR e 95 O THR e 111 SHEET 4 AD9 4 MET e 104 TRP e 107 -1 O MET e 104 N TRP e 101 SHEET 1 AE1 4 LEU f 4 SER f 7 0 SHEET 2 AE1 4 LEU f 18 ALA f 24 -1 O ALA f 23 N VAL f 5 SHEET 3 AE1 4 THR f 79 MET f 84 -1 O MET f 84 N LEU f 18 SHEET 4 AE1 4 PHE f 69 ASP f 74 -1 N ASP f 74 O THR f 79 SHEET 1 AE2 6 GLY f 10 SER f 11 0 SHEET 2 AE2 6 THR f 111 THR f 114 1 O THR f 114 N GLY f 10 SHEET 3 AE2 6 GLY f 93 TRP f 101 -1 N TYR f 95 O THR f 111 SHEET 4 AE2 6 ALA f 35 ARG f 40 -1 N TYR f 39 O TYR f 96 SHEET 5 AE2 6 GLU f 48 ASP f 55 -1 O GLU f 48 N ARG f 40 SHEET 6 AE2 6 SER f 58 TYR f 61 -1 O SER f 58 N ASP f 55 SHEET 1 AE3 4 GLY f 10 SER f 11 0 SHEET 2 AE3 4 THR f 111 THR f 114 1 O THR f 114 N GLY f 10 SHEET 3 AE3 4 GLY f 93 TRP f 101 -1 N TYR f 95 O THR f 111 SHEET 4 AE3 4 MET f 104 TRP f 107 -1 O MET f 104 N TRP f 101 SSBOND 1 CYS A 116 CYS A 573 1555 1555 2.06 SSBOND 2 CYS A 133 CYS A 529 1555 1555 2.04 SSBOND 3 CYS A 207 CYS A 271 1555 1555 2.05 SSBOND 4 CYS A 364 CYS A 412 1555 1555 2.06 SSBOND 5 CYS A 392 CYS A 532 1555 1555 2.06 SSBOND 6 CYS A 596 CYS A 633 1555 1555 2.06 SSBOND 7 CYS B 116 CYS B 573 1555 1555 2.06 SSBOND 8 CYS B 133 CYS B 529 1555 1555 2.04 SSBOND 9 CYS B 207 CYS B 271 1555 1555 2.05 SSBOND 10 CYS B 364 CYS B 412 1555 1555 2.05 SSBOND 11 CYS B 392 CYS B 532 1555 1555 2.06 SSBOND 12 CYS B 596 CYS B 633 1555 1555 2.05 SSBOND 13 CYS C 116 CYS C 573 1555 1555 2.06 SSBOND 14 CYS C 133 CYS C 529 1555 1555 2.04 SSBOND 15 CYS C 207 CYS C 271 1555 1555 2.05 SSBOND 16 CYS C 364 CYS C 412 1555 1555 2.04 SSBOND 17 CYS C 392 CYS C 532 1555 1555 2.05 SSBOND 18 CYS C 596 CYS C 633 1555 1555 2.05 SSBOND 19 CYS d 22 CYS d 97 1555 1555 2.06 SSBOND 20 CYS e 22 CYS e 97 1555 1555 2.08 SSBOND 21 CYS f 22 CYS f 97 1555 1555 2.06 LINK ND2 ASN A 141 C1 NAG F 1 1555 1555 1.45 LINK ND2 ASN A 398 C1 NAG D 1 1555 1555 1.46 LINK ND2 ASN A 430 C1 NAG K 1 1555 1555 1.46 LINK ND2 ASN A 674 C1 NAG M 1 1555 1555 1.46 LINK ND2 ASN B 141 C1 NAG G 1 1555 1555 1.45 LINK ND2 ASN B 398 C1 NAG L 1 1555 1555 1.46 LINK ND2 ASN B 430 C1 NAG J 1 1555 1555 1.46 LINK ND2 ASN B 674 C1 NAG N 1 1555 1555 1.46 LINK ND2 ASN C 141 C1 NAG H 1 1555 1555 1.45 LINK ND2 ASN C 398 C1 NAG E 1 1555 1555 1.46 LINK ND2 ASN C 430 C1 NAG I 1 1555 1555 1.46 LINK ND2 ASN C 674 C1 NAG O 1 1555 1555 1.46 LINK O4 NAG D 1 C1 NAG D 2 1555 1555 1.48 LINK O4 NAG E 1 C1 NAG E 2 1555 1555 1.48 LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.48 LINK O4 NAG G 1 C1 NAG G 2 1555 1555 1.48 LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.48 LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.48 LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.48 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.48 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.48 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.48 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.48 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.48 CISPEP 1 TYR A 282 PRO A 283 0 3.58 CISPEP 2 TYR B 282 PRO B 283 0 3.25 CISPEP 3 TYR C 282 PRO C 283 0 2.95 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000