HEADER MEMBRANE PROTEIN 09-APR-25 9QTN TITLE HUMAN ALPHA7 NICOTINIC RECEPTOR IN COMPLEX WITH THE F1 NANOBODY COMPND MOL_ID: 1; COMPND 2 MOLECULE: NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7; COMPND 3 CHAIN: A, B, C, D, E; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: NANOBODY F1; COMPND 7 CHAIN: F, G, H, I, J; COMPND 8 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: CHRNA7, NACHRA7; SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: HEK293; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: VICUGNA PACOS; SOURCE 11 ORGANISM_TAXID: 30538; SOURCE 12 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS NICOTINIC RECEPTOR, NANOBODY, MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR N.BARILONE,M.VANGELATOU,F.Z.MAROUF,G.DEJEAN DE LA BATIE,G.AYME, AUTHOR 2 P.LAFAYE,P.-J.CORRINGER,M.S.PREVOST REVDAT 1 18-FEB-26 9QTN 0 JRNL AUTH N.BARILONE,M.VANGELATOU,F.Z.MAROUF,G.DEJEAN DE LA BATIE, JRNL AUTH 2 Q.LI,P.LAFAYE,G.AYME,P.J.CORRINGER,M.S.PREVOST JRNL TITL DISCOVERY AND MECHANISM OF NEGATIVE ALLOSTERIC MODULATION OF JRNL TITL 2 THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR BY NANOBODIES. JRNL REF PROC.NATL.ACAD.SCI.USA V. 123 34123 2026 JRNL REFN ESSN 1091-6490 JRNL PMID 41576092 JRNL DOI 10.1073/PNAS.2514734123 REMARK 2 REMARK 2 RESOLUTION. 2.28 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : PHENIX REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.280 REMARK 3 NUMBER OF PARTICLES : 325670 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9QTN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 09-APR-25. REMARK 100 THE DEPOSITION ID IS D_1292145658. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : HUMAN NICOTINIC ACETYLCHOLINE REMARK 245 RECEPTOR ALPHA7 IN COMPLEX WITH REMARK 245 NANOBODY F1 REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.70 REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.80 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS TITAN THEMIS REMARK 245 DETECTOR TYPE : GATAN K3 BIOQUANTUM (6K X REMARK 245 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 700.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2750.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : OTHER REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 3000.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DECAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J, REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S, REMARK 350 AND CHAINS: T, U, V, W, X, Y REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 TYR A 209 REMARK 465 TYR A 210 REMARK 465 GLY A 211 REMARK 465 LEU A 212 REMARK 465 ASN A 213 REMARK 465 LEU A 214 REMARK 465 LEU A 215 REMARK 465 ILE A 216 REMARK 465 PRO A 217 REMARK 465 CYS A 218 REMARK 465 VAL A 219 REMARK 465 LEU A 220 REMARK 465 ILE A 221 REMARK 465 SER A 222 REMARK 465 ALA A 223 REMARK 465 LEU A 224 REMARK 465 ALA A 225 REMARK 465 LEU A 226 REMARK 465 LEU A 227 REMARK 465 VAL A 228 REMARK 465 PHE A 229 REMARK 465 LEU A 230 REMARK 465 LEU A 231 REMARK 465 PRO A 232 REMARK 465 ALA A 233 REMARK 465 ASP A 234 REMARK 465 SER A 235 REMARK 465 GLY A 236 REMARK 465 GLU A 237 REMARK 465 LYS A 238 REMARK 465 ILE A 239 REMARK 465 SER A 240 REMARK 465 LEU A 241 REMARK 465 GLY A 242 REMARK 465 ILE A 243 REMARK 465 THR A 244 REMARK 465 VAL A 245 REMARK 465 LEU A 246 REMARK 465 LEU A 247 REMARK 465 SER A 248 REMARK 465 LEU A 249 REMARK 465 THR A 250 REMARK 465 VAL A 251 REMARK 465 PHE A 252 REMARK 465 MET A 253 REMARK 465 LEU A 254 REMARK 465 LEU A 255 REMARK 465 VAL A 256 REMARK 465 ALA A 257 REMARK 465 GLU A 258 REMARK 465 ILE A 259 REMARK 465 MET A 260 REMARK 465 PRO A 261 REMARK 465 ALA A 262 REMARK 465 THR A 263 REMARK 465 SER A 264 REMARK 465 ASP A 265 REMARK 465 SER A 266 REMARK 465 VAL A 267 REMARK 465 PRO A 268 REMARK 465 LEU A 269 REMARK 465 ILE A 270 REMARK 465 ALA A 271 REMARK 465 GLN A 272 REMARK 465 TYR A 273 REMARK 465 PHE A 274 REMARK 465 ALA A 275 REMARK 465 SER A 276 REMARK 465 THR A 277 REMARK 465 MET A 278 REMARK 465 ILE A 279 REMARK 465 ILE A 280 REMARK 465 VAL A 281 REMARK 465 GLY A 282 REMARK 465 LEU A 283 REMARK 465 SER A 284 REMARK 465 VAL A 285 REMARK 465 VAL A 286 REMARK 465 VAL A 287 REMARK 465 THR A 288 REMARK 465 VAL A 289 REMARK 465 ILE A 290 REMARK 465 VAL A 291 REMARK 465 LEU A 292 REMARK 465 GLN A 293 REMARK 465 TYR A 294 REMARK 465 HIS A 295 REMARK 465 HIS A 296 REMARK 465 HIS A 297 REMARK 465 ASP A 298 REMARK 465 PRO A 299 REMARK 465 ASP A 300 REMARK 465 GLY A 301 REMARK 465 GLY A 302 REMARK 465 LYS A 303 REMARK 465 MET A 304 REMARK 465 PRO A 305 REMARK 465 LYS A 306 REMARK 465 TRP A 307 REMARK 465 THR A 308 REMARK 465 ARG A 309 REMARK 465 VAL A 310 REMARK 465 ILE A 311 REMARK 465 LEU A 312 REMARK 465 LEU A 313 REMARK 465 ASN A 314 REMARK 465 TRP A 315 REMARK 465 CYS A 316 REMARK 465 ALA A 317 REMARK 465 TRP A 318 REMARK 465 PHE A 319 REMARK 465 LEU A 320 REMARK 465 ARG A 321 REMARK 465 MET A 322 REMARK 465 LYS A 323 REMARK 465 ARG A 324 REMARK 465 PRO A 325 REMARK 465 GLY A 326 REMARK 465 GLU A 327 REMARK 465 ASP A 328 REMARK 465 LYS A 329 REMARK 465 VAL A 330 REMARK 465 ARG A 331 REMARK 465 PRO A 332 REMARK 465 ALA A 333 REMARK 465 CYS A 334 REMARK 465 GLN A 335 REMARK 465 HIS A 336 REMARK 465 LYS A 337 REMARK 465 GLN A 338 REMARK 465 ARG A 339 REMARK 465 ARG A 340 REMARK 465 CYS A 341 REMARK 465 SER A 342 REMARK 465 LEU A 343 REMARK 465 ALA A 344 REMARK 465 SER A 345 REMARK 465 VAL A 346 REMARK 465 GLU A 347 REMARK 465 MET A 348 REMARK 465 SER A 349 REMARK 465 ALA A 350 REMARK 465 VAL A 351 REMARK 465 ALA A 352 REMARK 465 PRO A 353 REMARK 465 PRO A 354 REMARK 465 PRO A 355 REMARK 465 ALA A 356 REMARK 465 SER A 357 REMARK 465 ASN A 358 REMARK 465 GLY A 359 REMARK 465 ASN A 360 REMARK 465 LEU A 361 REMARK 465 LEU A 362 REMARK 465 TYR A 363 REMARK 465 ILE A 364 REMARK 465 GLY A 365 REMARK 465 PHE A 366 REMARK 465 ARG A 367 REMARK 465 GLY A 368 REMARK 465 LEU A 369 REMARK 465 ASP A 370 REMARK 465 GLY A 371 REMARK 465 VAL A 372 REMARK 465 HIS A 373 REMARK 465 CYS A 374 REMARK 465 VAL A 375 REMARK 465 PRO A 376 REMARK 465 THR A 377 REMARK 465 PRO A 378 REMARK 465 ASP A 379 REMARK 465 SER A 380 REMARK 465 GLY A 381 REMARK 465 VAL A 382 REMARK 465 VAL A 383 REMARK 465 CYS A 384 REMARK 465 GLY A 385 REMARK 465 ARG A 386 REMARK 465 MET A 387 REMARK 465 ALA A 388 REMARK 465 CYS A 389 REMARK 465 SER A 390 REMARK 465 PRO A 391 REMARK 465 THR A 392 REMARK 465 HIS A 393 REMARK 465 ASP A 394 REMARK 465 GLU A 395 REMARK 465 HIS A 396 REMARK 465 LEU A 397 REMARK 465 LEU A 398 REMARK 465 HIS A 399 REMARK 465 GLY A 400 REMARK 465 GLY A 401 REMARK 465 GLN A 402 REMARK 465 PRO A 403 REMARK 465 PRO A 404 REMARK 465 GLU A 405 REMARK 465 GLY A 406 REMARK 465 ASP A 407 REMARK 465 PRO A 408 REMARK 465 ASP A 409 REMARK 465 LEU A 410 REMARK 465 ALA A 411 REMARK 465 LYS A 412 REMARK 465 ILE A 413 REMARK 465 LEU A 414 REMARK 465 GLU A 415 REMARK 465 GLU A 416 REMARK 465 VAL A 417 REMARK 465 ARG A 418 REMARK 465 TYR A 419 REMARK 465 ILE A 420 REMARK 465 ALA A 421 REMARK 465 ASN A 422 REMARK 465 ARG A 423 REMARK 465 PHE A 424 REMARK 465 ARG A 425 REMARK 465 CYS A 426 REMARK 465 GLN A 427 REMARK 465 ASP A 428 REMARK 465 GLU A 429 REMARK 465 SER A 430 REMARK 465 GLU A 431 REMARK 465 ALA A 432 REMARK 465 VAL A 433 REMARK 465 CYS A 434 REMARK 465 SER A 435 REMARK 465 GLU A 436 REMARK 465 TRP A 437 REMARK 465 LYS A 438 REMARK 465 PHE A 439 REMARK 465 ALA A 440 REMARK 465 ALA A 441 REMARK 465 CYS A 442 REMARK 465 VAL A 443 REMARK 465 VAL A 444 REMARK 465 ASP A 445 REMARK 465 ARG A 446 REMARK 465 LEU A 447 REMARK 465 CYS A 448 REMARK 465 LEU A 449 REMARK 465 MET A 450 REMARK 465 ALA A 451 REMARK 465 PHE A 452 REMARK 465 SER A 453 REMARK 465 VAL A 454 REMARK 465 PHE A 455 REMARK 465 THR A 456 REMARK 465 ILE A 457 REMARK 465 ILE A 458 REMARK 465 CYS A 459 REMARK 465 THR A 460 REMARK 465 ILE A 461 REMARK 465 GLY A 462 REMARK 465 ILE A 463 REMARK 465 LEU A 464 REMARK 465 MET A 465 REMARK 465 SER A 466 REMARK 465 ALA A 467 REMARK 465 PRO A 468 REMARK 465 ASN A 469 REMARK 465 PHE A 470 REMARK 465 VAL A 471 REMARK 465 GLU A 472 REMARK 465 ALA A 473 REMARK 465 VAL A 474 REMARK 465 SER A 475 REMARK 465 LYS A 476 REMARK 465 ASP A 477 REMARK 465 PHE A 478 REMARK 465 ALA A 479 REMARK 465 TYR B 209 REMARK 465 TYR B 210 REMARK 465 GLY B 211 REMARK 465 LEU B 212 REMARK 465 ASN B 213 REMARK 465 LEU B 214 REMARK 465 LEU B 215 REMARK 465 ILE B 216 REMARK 465 PRO B 217 REMARK 465 CYS B 218 REMARK 465 VAL B 219 REMARK 465 LEU B 220 REMARK 465 ILE B 221 REMARK 465 SER B 222 REMARK 465 ALA B 223 REMARK 465 LEU B 224 REMARK 465 ALA B 225 REMARK 465 LEU B 226 REMARK 465 LEU B 227 REMARK 465 VAL B 228 REMARK 465 PHE B 229 REMARK 465 LEU B 230 REMARK 465 LEU B 231 REMARK 465 PRO B 232 REMARK 465 ALA B 233 REMARK 465 ASP B 234 REMARK 465 SER B 235 REMARK 465 GLY B 236 REMARK 465 GLU B 237 REMARK 465 LYS B 238 REMARK 465 ILE B 239 REMARK 465 SER B 240 REMARK 465 LEU B 241 REMARK 465 GLY B 242 REMARK 465 ILE B 243 REMARK 465 THR B 244 REMARK 465 VAL B 245 REMARK 465 LEU B 246 REMARK 465 LEU B 247 REMARK 465 SER B 248 REMARK 465 LEU B 249 REMARK 465 THR B 250 REMARK 465 VAL B 251 REMARK 465 PHE B 252 REMARK 465 MET B 253 REMARK 465 LEU B 254 REMARK 465 LEU B 255 REMARK 465 VAL B 256 REMARK 465 ALA B 257 REMARK 465 GLU B 258 REMARK 465 ILE B 259 REMARK 465 MET B 260 REMARK 465 PRO B 261 REMARK 465 ALA B 262 REMARK 465 THR B 263 REMARK 465 SER B 264 REMARK 465 ASP B 265 REMARK 465 SER B 266 REMARK 465 VAL B 267 REMARK 465 PRO B 268 REMARK 465 LEU B 269 REMARK 465 ILE B 270 REMARK 465 ALA B 271 REMARK 465 GLN B 272 REMARK 465 TYR B 273 REMARK 465 PHE B 274 REMARK 465 ALA B 275 REMARK 465 SER B 276 REMARK 465 THR B 277 REMARK 465 MET B 278 REMARK 465 ILE B 279 REMARK 465 ILE B 280 REMARK 465 VAL B 281 REMARK 465 GLY B 282 REMARK 465 LEU B 283 REMARK 465 SER B 284 REMARK 465 VAL B 285 REMARK 465 VAL B 286 REMARK 465 VAL B 287 REMARK 465 THR B 288 REMARK 465 VAL B 289 REMARK 465 ILE B 290 REMARK 465 VAL B 291 REMARK 465 LEU B 292 REMARK 465 GLN B 293 REMARK 465 TYR B 294 REMARK 465 HIS B 295 REMARK 465 HIS B 296 REMARK 465 HIS B 297 REMARK 465 ASP B 298 REMARK 465 PRO B 299 REMARK 465 ASP B 300 REMARK 465 GLY B 301 REMARK 465 GLY B 302 REMARK 465 LYS B 303 REMARK 465 MET B 304 REMARK 465 PRO B 305 REMARK 465 LYS B 306 REMARK 465 TRP B 307 REMARK 465 THR B 308 REMARK 465 ARG B 309 REMARK 465 VAL B 310 REMARK 465 ILE B 311 REMARK 465 LEU B 312 REMARK 465 LEU B 313 REMARK 465 ASN B 314 REMARK 465 TRP B 315 REMARK 465 CYS B 316 REMARK 465 ALA B 317 REMARK 465 TRP B 318 REMARK 465 PHE B 319 REMARK 465 LEU B 320 REMARK 465 ARG B 321 REMARK 465 MET B 322 REMARK 465 LYS B 323 REMARK 465 ARG B 324 REMARK 465 PRO B 325 REMARK 465 GLY B 326 REMARK 465 GLU B 327 REMARK 465 ASP B 328 REMARK 465 LYS B 329 REMARK 465 VAL B 330 REMARK 465 ARG B 331 REMARK 465 PRO B 332 REMARK 465 ALA B 333 REMARK 465 CYS B 334 REMARK 465 GLN B 335 REMARK 465 HIS B 336 REMARK 465 LYS B 337 REMARK 465 GLN B 338 REMARK 465 ARG B 339 REMARK 465 ARG B 340 REMARK 465 CYS B 341 REMARK 465 SER B 342 REMARK 465 LEU B 343 REMARK 465 ALA B 344 REMARK 465 SER B 345 REMARK 465 VAL B 346 REMARK 465 GLU B 347 REMARK 465 MET B 348 REMARK 465 SER B 349 REMARK 465 ALA B 350 REMARK 465 VAL B 351 REMARK 465 ALA B 352 REMARK 465 PRO B 353 REMARK 465 PRO B 354 REMARK 465 PRO B 355 REMARK 465 ALA B 356 REMARK 465 SER B 357 REMARK 465 ASN B 358 REMARK 465 GLY B 359 REMARK 465 ASN B 360 REMARK 465 LEU B 361 REMARK 465 LEU B 362 REMARK 465 TYR B 363 REMARK 465 ILE B 364 REMARK 465 GLY B 365 REMARK 465 PHE B 366 REMARK 465 ARG B 367 REMARK 465 GLY B 368 REMARK 465 LEU B 369 REMARK 465 ASP B 370 REMARK 465 GLY B 371 REMARK 465 VAL B 372 REMARK 465 HIS B 373 REMARK 465 CYS B 374 REMARK 465 VAL B 375 REMARK 465 PRO B 376 REMARK 465 THR B 377 REMARK 465 PRO B 378 REMARK 465 ASP B 379 REMARK 465 SER B 380 REMARK 465 GLY B 381 REMARK 465 VAL B 382 REMARK 465 VAL B 383 REMARK 465 CYS B 384 REMARK 465 GLY B 385 REMARK 465 ARG B 386 REMARK 465 MET B 387 REMARK 465 ALA B 388 REMARK 465 CYS B 389 REMARK 465 SER B 390 REMARK 465 PRO B 391 REMARK 465 THR B 392 REMARK 465 HIS B 393 REMARK 465 ASP B 394 REMARK 465 GLU B 395 REMARK 465 HIS B 396 REMARK 465 LEU B 397 REMARK 465 LEU B 398 REMARK 465 HIS B 399 REMARK 465 GLY B 400 REMARK 465 GLY B 401 REMARK 465 GLN B 402 REMARK 465 PRO B 403 REMARK 465 PRO B 404 REMARK 465 GLU B 405 REMARK 465 GLY B 406 REMARK 465 ASP B 407 REMARK 465 PRO B 408 REMARK 465 ASP B 409 REMARK 465 LEU B 410 REMARK 465 ALA B 411 REMARK 465 LYS B 412 REMARK 465 ILE B 413 REMARK 465 LEU B 414 REMARK 465 GLU B 415 REMARK 465 GLU B 416 REMARK 465 VAL B 417 REMARK 465 ARG B 418 REMARK 465 TYR B 419 REMARK 465 ILE B 420 REMARK 465 ALA B 421 REMARK 465 ASN B 422 REMARK 465 ARG B 423 REMARK 465 PHE B 424 REMARK 465 ARG B 425 REMARK 465 CYS B 426 REMARK 465 GLN B 427 REMARK 465 ASP B 428 REMARK 465 GLU B 429 REMARK 465 SER B 430 REMARK 465 GLU B 431 REMARK 465 ALA B 432 REMARK 465 VAL B 433 REMARK 465 CYS B 434 REMARK 465 SER B 435 REMARK 465 GLU B 436 REMARK 465 TRP B 437 REMARK 465 LYS B 438 REMARK 465 PHE B 439 REMARK 465 ALA B 440 REMARK 465 ALA B 441 REMARK 465 CYS B 442 REMARK 465 VAL B 443 REMARK 465 VAL B 444 REMARK 465 ASP B 445 REMARK 465 ARG B 446 REMARK 465 LEU B 447 REMARK 465 CYS B 448 REMARK 465 LEU B 449 REMARK 465 MET B 450 REMARK 465 ALA B 451 REMARK 465 PHE B 452 REMARK 465 SER B 453 REMARK 465 VAL B 454 REMARK 465 PHE B 455 REMARK 465 THR B 456 REMARK 465 ILE B 457 REMARK 465 ILE B 458 REMARK 465 CYS B 459 REMARK 465 THR B 460 REMARK 465 ILE B 461 REMARK 465 GLY B 462 REMARK 465 ILE B 463 REMARK 465 LEU B 464 REMARK 465 MET B 465 REMARK 465 SER B 466 REMARK 465 ALA B 467 REMARK 465 PRO B 468 REMARK 465 ASN B 469 REMARK 465 PHE B 470 REMARK 465 VAL B 471 REMARK 465 GLU B 472 REMARK 465 ALA B 473 REMARK 465 VAL B 474 REMARK 465 SER B 475 REMARK 465 LYS B 476 REMARK 465 ASP B 477 REMARK 465 PHE B 478 REMARK 465 ALA B 479 REMARK 465 TYR C 209 REMARK 465 TYR C 210 REMARK 465 GLY C 211 REMARK 465 LEU C 212 REMARK 465 ASN C 213 REMARK 465 LEU C 214 REMARK 465 LEU C 215 REMARK 465 ILE C 216 REMARK 465 PRO C 217 REMARK 465 CYS C 218 REMARK 465 VAL C 219 REMARK 465 LEU C 220 REMARK 465 ILE C 221 REMARK 465 SER C 222 REMARK 465 ALA C 223 REMARK 465 LEU C 224 REMARK 465 ALA C 225 REMARK 465 LEU C 226 REMARK 465 LEU C 227 REMARK 465 VAL C 228 REMARK 465 PHE C 229 REMARK 465 LEU C 230 REMARK 465 LEU C 231 REMARK 465 PRO C 232 REMARK 465 ALA C 233 REMARK 465 ASP C 234 REMARK 465 SER C 235 REMARK 465 GLY C 236 REMARK 465 GLU C 237 REMARK 465 LYS C 238 REMARK 465 ILE C 239 REMARK 465 SER C 240 REMARK 465 LEU C 241 REMARK 465 GLY C 242 REMARK 465 ILE C 243 REMARK 465 THR C 244 REMARK 465 VAL C 245 REMARK 465 LEU C 246 REMARK 465 LEU C 247 REMARK 465 SER C 248 REMARK 465 LEU C 249 REMARK 465 THR C 250 REMARK 465 VAL C 251 REMARK 465 PHE C 252 REMARK 465 MET C 253 REMARK 465 LEU C 254 REMARK 465 LEU C 255 REMARK 465 VAL C 256 REMARK 465 ALA C 257 REMARK 465 GLU C 258 REMARK 465 ILE C 259 REMARK 465 MET C 260 REMARK 465 PRO C 261 REMARK 465 ALA C 262 REMARK 465 THR C 263 REMARK 465 SER C 264 REMARK 465 ASP C 265 REMARK 465 SER C 266 REMARK 465 VAL C 267 REMARK 465 PRO C 268 REMARK 465 LEU C 269 REMARK 465 ILE C 270 REMARK 465 ALA C 271 REMARK 465 GLN C 272 REMARK 465 TYR C 273 REMARK 465 PHE C 274 REMARK 465 ALA C 275 REMARK 465 SER C 276 REMARK 465 THR C 277 REMARK 465 MET C 278 REMARK 465 ILE C 279 REMARK 465 ILE C 280 REMARK 465 VAL C 281 REMARK 465 GLY C 282 REMARK 465 LEU C 283 REMARK 465 SER C 284 REMARK 465 VAL C 285 REMARK 465 VAL C 286 REMARK 465 VAL C 287 REMARK 465 THR C 288 REMARK 465 VAL C 289 REMARK 465 ILE C 290 REMARK 465 VAL C 291 REMARK 465 LEU C 292 REMARK 465 GLN C 293 REMARK 465 TYR C 294 REMARK 465 HIS C 295 REMARK 465 HIS C 296 REMARK 465 HIS C 297 REMARK 465 ASP C 298 REMARK 465 PRO C 299 REMARK 465 ASP C 300 REMARK 465 GLY C 301 REMARK 465 GLY C 302 REMARK 465 LYS C 303 REMARK 465 MET C 304 REMARK 465 PRO C 305 REMARK 465 LYS C 306 REMARK 465 TRP C 307 REMARK 465 THR C 308 REMARK 465 ARG C 309 REMARK 465 VAL C 310 REMARK 465 ILE C 311 REMARK 465 LEU C 312 REMARK 465 LEU C 313 REMARK 465 ASN C 314 REMARK 465 TRP C 315 REMARK 465 CYS C 316 REMARK 465 ALA C 317 REMARK 465 TRP C 318 REMARK 465 PHE C 319 REMARK 465 LEU C 320 REMARK 465 ARG C 321 REMARK 465 MET C 322 REMARK 465 LYS C 323 REMARK 465 ARG C 324 REMARK 465 PRO C 325 REMARK 465 GLY C 326 REMARK 465 GLU C 327 REMARK 465 ASP C 328 REMARK 465 LYS C 329 REMARK 465 VAL C 330 REMARK 465 ARG C 331 REMARK 465 PRO C 332 REMARK 465 ALA C 333 REMARK 465 CYS C 334 REMARK 465 GLN C 335 REMARK 465 HIS C 336 REMARK 465 LYS C 337 REMARK 465 GLN C 338 REMARK 465 ARG C 339 REMARK 465 ARG C 340 REMARK 465 CYS C 341 REMARK 465 SER C 342 REMARK 465 LEU C 343 REMARK 465 ALA C 344 REMARK 465 SER C 345 REMARK 465 VAL C 346 REMARK 465 GLU C 347 REMARK 465 MET C 348 REMARK 465 SER C 349 REMARK 465 ALA C 350 REMARK 465 VAL C 351 REMARK 465 ALA C 352 REMARK 465 PRO C 353 REMARK 465 PRO C 354 REMARK 465 PRO C 355 REMARK 465 ALA C 356 REMARK 465 SER C 357 REMARK 465 ASN C 358 REMARK 465 GLY C 359 REMARK 465 ASN C 360 REMARK 465 LEU C 361 REMARK 465 LEU C 362 REMARK 465 TYR C 363 REMARK 465 ILE C 364 REMARK 465 GLY C 365 REMARK 465 PHE C 366 REMARK 465 ARG C 367 REMARK 465 GLY C 368 REMARK 465 LEU C 369 REMARK 465 ASP C 370 REMARK 465 GLY C 371 REMARK 465 VAL C 372 REMARK 465 HIS C 373 REMARK 465 CYS C 374 REMARK 465 VAL C 375 REMARK 465 PRO C 376 REMARK 465 THR C 377 REMARK 465 PRO C 378 REMARK 465 ASP C 379 REMARK 465 SER C 380 REMARK 465 GLY C 381 REMARK 465 VAL C 382 REMARK 465 VAL C 383 REMARK 465 CYS C 384 REMARK 465 GLY C 385 REMARK 465 ARG C 386 REMARK 465 MET C 387 REMARK 465 ALA C 388 REMARK 465 CYS C 389 REMARK 465 SER C 390 REMARK 465 PRO C 391 REMARK 465 THR C 392 REMARK 465 HIS C 393 REMARK 465 ASP C 394 REMARK 465 GLU C 395 REMARK 465 HIS C 396 REMARK 465 LEU C 397 REMARK 465 LEU C 398 REMARK 465 HIS C 399 REMARK 465 GLY C 400 REMARK 465 GLY C 401 REMARK 465 GLN C 402 REMARK 465 PRO C 403 REMARK 465 PRO C 404 REMARK 465 GLU C 405 REMARK 465 GLY C 406 REMARK 465 ASP C 407 REMARK 465 PRO C 408 REMARK 465 ASP C 409 REMARK 465 LEU C 410 REMARK 465 ALA C 411 REMARK 465 LYS C 412 REMARK 465 ILE C 413 REMARK 465 LEU C 414 REMARK 465 GLU C 415 REMARK 465 GLU C 416 REMARK 465 VAL C 417 REMARK 465 ARG C 418 REMARK 465 TYR C 419 REMARK 465 ILE C 420 REMARK 465 ALA C 421 REMARK 465 ASN C 422 REMARK 465 ARG C 423 REMARK 465 PHE C 424 REMARK 465 ARG C 425 REMARK 465 CYS C 426 REMARK 465 GLN C 427 REMARK 465 ASP C 428 REMARK 465 GLU C 429 REMARK 465 SER C 430 REMARK 465 GLU C 431 REMARK 465 ALA C 432 REMARK 465 VAL C 433 REMARK 465 CYS C 434 REMARK 465 SER C 435 REMARK 465 GLU C 436 REMARK 465 TRP C 437 REMARK 465 LYS C 438 REMARK 465 PHE C 439 REMARK 465 ALA C 440 REMARK 465 ALA C 441 REMARK 465 CYS C 442 REMARK 465 VAL C 443 REMARK 465 VAL C 444 REMARK 465 ASP C 445 REMARK 465 ARG C 446 REMARK 465 LEU C 447 REMARK 465 CYS C 448 REMARK 465 LEU C 449 REMARK 465 MET C 450 REMARK 465 ALA C 451 REMARK 465 PHE C 452 REMARK 465 SER C 453 REMARK 465 VAL C 454 REMARK 465 PHE C 455 REMARK 465 THR C 456 REMARK 465 ILE C 457 REMARK 465 ILE C 458 REMARK 465 CYS C 459 REMARK 465 THR C 460 REMARK 465 ILE C 461 REMARK 465 GLY C 462 REMARK 465 ILE C 463 REMARK 465 LEU C 464 REMARK 465 MET C 465 REMARK 465 SER C 466 REMARK 465 ALA C 467 REMARK 465 PRO C 468 REMARK 465 ASN C 469 REMARK 465 PHE C 470 REMARK 465 VAL C 471 REMARK 465 GLU C 472 REMARK 465 ALA C 473 REMARK 465 VAL C 474 REMARK 465 SER C 475 REMARK 465 LYS C 476 REMARK 465 ASP C 477 REMARK 465 PHE C 478 REMARK 465 ALA C 479 REMARK 465 TYR D 209 REMARK 465 TYR D 210 REMARK 465 GLY D 211 REMARK 465 LEU D 212 REMARK 465 ASN D 213 REMARK 465 LEU D 214 REMARK 465 LEU D 215 REMARK 465 ILE D 216 REMARK 465 PRO D 217 REMARK 465 CYS D 218 REMARK 465 VAL D 219 REMARK 465 LEU D 220 REMARK 465 ILE D 221 REMARK 465 SER D 222 REMARK 465 ALA D 223 REMARK 465 LEU D 224 REMARK 465 ALA D 225 REMARK 465 LEU D 226 REMARK 465 LEU D 227 REMARK 465 VAL D 228 REMARK 465 PHE D 229 REMARK 465 LEU D 230 REMARK 465 LEU D 231 REMARK 465 PRO D 232 REMARK 465 ALA D 233 REMARK 465 ASP D 234 REMARK 465 SER D 235 REMARK 465 GLY D 236 REMARK 465 GLU D 237 REMARK 465 LYS D 238 REMARK 465 ILE D 239 REMARK 465 SER D 240 REMARK 465 LEU D 241 REMARK 465 GLY D 242 REMARK 465 ILE D 243 REMARK 465 THR D 244 REMARK 465 VAL D 245 REMARK 465 LEU D 246 REMARK 465 LEU D 247 REMARK 465 SER D 248 REMARK 465 LEU D 249 REMARK 465 THR D 250 REMARK 465 VAL D 251 REMARK 465 PHE D 252 REMARK 465 MET D 253 REMARK 465 LEU D 254 REMARK 465 LEU D 255 REMARK 465 VAL D 256 REMARK 465 ALA D 257 REMARK 465 GLU D 258 REMARK 465 ILE D 259 REMARK 465 MET D 260 REMARK 465 PRO D 261 REMARK 465 ALA D 262 REMARK 465 THR D 263 REMARK 465 SER D 264 REMARK 465 ASP D 265 REMARK 465 SER D 266 REMARK 465 VAL D 267 REMARK 465 PRO D 268 REMARK 465 LEU D 269 REMARK 465 ILE D 270 REMARK 465 ALA D 271 REMARK 465 GLN D 272 REMARK 465 TYR D 273 REMARK 465 PHE D 274 REMARK 465 ALA D 275 REMARK 465 SER D 276 REMARK 465 THR D 277 REMARK 465 MET D 278 REMARK 465 ILE D 279 REMARK 465 ILE D 280 REMARK 465 VAL D 281 REMARK 465 GLY D 282 REMARK 465 LEU D 283 REMARK 465 SER D 284 REMARK 465 VAL D 285 REMARK 465 VAL D 286 REMARK 465 VAL D 287 REMARK 465 THR D 288 REMARK 465 VAL D 289 REMARK 465 ILE D 290 REMARK 465 VAL D 291 REMARK 465 LEU D 292 REMARK 465 GLN D 293 REMARK 465 TYR D 294 REMARK 465 HIS D 295 REMARK 465 HIS D 296 REMARK 465 HIS D 297 REMARK 465 ASP D 298 REMARK 465 PRO D 299 REMARK 465 ASP D 300 REMARK 465 GLY D 301 REMARK 465 GLY D 302 REMARK 465 LYS D 303 REMARK 465 MET D 304 REMARK 465 PRO D 305 REMARK 465 LYS D 306 REMARK 465 TRP D 307 REMARK 465 THR D 308 REMARK 465 ARG D 309 REMARK 465 VAL D 310 REMARK 465 ILE D 311 REMARK 465 LEU D 312 REMARK 465 LEU D 313 REMARK 465 ASN D 314 REMARK 465 TRP D 315 REMARK 465 CYS D 316 REMARK 465 ALA D 317 REMARK 465 TRP D 318 REMARK 465 PHE D 319 REMARK 465 LEU D 320 REMARK 465 ARG D 321 REMARK 465 MET D 322 REMARK 465 LYS D 323 REMARK 465 ARG D 324 REMARK 465 PRO D 325 REMARK 465 GLY D 326 REMARK 465 GLU D 327 REMARK 465 ASP D 328 REMARK 465 LYS D 329 REMARK 465 VAL D 330 REMARK 465 ARG D 331 REMARK 465 PRO D 332 REMARK 465 ALA D 333 REMARK 465 CYS D 334 REMARK 465 GLN D 335 REMARK 465 HIS D 336 REMARK 465 LYS D 337 REMARK 465 GLN D 338 REMARK 465 ARG D 339 REMARK 465 ARG D 340 REMARK 465 CYS D 341 REMARK 465 SER D 342 REMARK 465 LEU D 343 REMARK 465 ALA D 344 REMARK 465 SER D 345 REMARK 465 VAL D 346 REMARK 465 GLU D 347 REMARK 465 MET D 348 REMARK 465 SER D 349 REMARK 465 ALA D 350 REMARK 465 VAL D 351 REMARK 465 ALA D 352 REMARK 465 PRO D 353 REMARK 465 PRO D 354 REMARK 465 PRO D 355 REMARK 465 ALA D 356 REMARK 465 SER D 357 REMARK 465 ASN D 358 REMARK 465 GLY D 359 REMARK 465 ASN D 360 REMARK 465 LEU D 361 REMARK 465 LEU D 362 REMARK 465 TYR D 363 REMARK 465 ILE D 364 REMARK 465 GLY D 365 REMARK 465 PHE D 366 REMARK 465 ARG D 367 REMARK 465 GLY D 368 REMARK 465 LEU D 369 REMARK 465 ASP D 370 REMARK 465 GLY D 371 REMARK 465 VAL D 372 REMARK 465 HIS D 373 REMARK 465 CYS D 374 REMARK 465 VAL D 375 REMARK 465 PRO D 376 REMARK 465 THR D 377 REMARK 465 PRO D 378 REMARK 465 ASP D 379 REMARK 465 SER D 380 REMARK 465 GLY D 381 REMARK 465 VAL D 382 REMARK 465 VAL D 383 REMARK 465 CYS D 384 REMARK 465 GLY D 385 REMARK 465 ARG D 386 REMARK 465 MET D 387 REMARK 465 ALA D 388 REMARK 465 CYS D 389 REMARK 465 SER D 390 REMARK 465 PRO D 391 REMARK 465 THR D 392 REMARK 465 HIS D 393 REMARK 465 ASP D 394 REMARK 465 GLU D 395 REMARK 465 HIS D 396 REMARK 465 LEU D 397 REMARK 465 LEU D 398 REMARK 465 HIS D 399 REMARK 465 GLY D 400 REMARK 465 GLY D 401 REMARK 465 GLN D 402 REMARK 465 PRO D 403 REMARK 465 PRO D 404 REMARK 465 GLU D 405 REMARK 465 GLY D 406 REMARK 465 ASP D 407 REMARK 465 PRO D 408 REMARK 465 ASP D 409 REMARK 465 LEU D 410 REMARK 465 ALA D 411 REMARK 465 LYS D 412 REMARK 465 ILE D 413 REMARK 465 LEU D 414 REMARK 465 GLU D 415 REMARK 465 GLU D 416 REMARK 465 VAL D 417 REMARK 465 ARG D 418 REMARK 465 TYR D 419 REMARK 465 ILE D 420 REMARK 465 ALA D 421 REMARK 465 ASN D 422 REMARK 465 ARG D 423 REMARK 465 PHE D 424 REMARK 465 ARG D 425 REMARK 465 CYS D 426 REMARK 465 GLN D 427 REMARK 465 ASP D 428 REMARK 465 GLU D 429 REMARK 465 SER D 430 REMARK 465 GLU D 431 REMARK 465 ALA D 432 REMARK 465 VAL D 433 REMARK 465 CYS D 434 REMARK 465 SER D 435 REMARK 465 GLU D 436 REMARK 465 TRP D 437 REMARK 465 LYS D 438 REMARK 465 PHE D 439 REMARK 465 ALA D 440 REMARK 465 ALA D 441 REMARK 465 CYS D 442 REMARK 465 VAL D 443 REMARK 465 VAL D 444 REMARK 465 ASP D 445 REMARK 465 ARG D 446 REMARK 465 LEU D 447 REMARK 465 CYS D 448 REMARK 465 LEU D 449 REMARK 465 MET D 450 REMARK 465 ALA D 451 REMARK 465 PHE D 452 REMARK 465 SER D 453 REMARK 465 VAL D 454 REMARK 465 PHE D 455 REMARK 465 THR D 456 REMARK 465 ILE D 457 REMARK 465 ILE D 458 REMARK 465 CYS D 459 REMARK 465 THR D 460 REMARK 465 ILE D 461 REMARK 465 GLY D 462 REMARK 465 ILE D 463 REMARK 465 LEU D 464 REMARK 465 MET D 465 REMARK 465 SER D 466 REMARK 465 ALA D 467 REMARK 465 PRO D 468 REMARK 465 ASN D 469 REMARK 465 PHE D 470 REMARK 465 VAL D 471 REMARK 465 GLU D 472 REMARK 465 ALA D 473 REMARK 465 VAL D 474 REMARK 465 SER D 475 REMARK 465 LYS D 476 REMARK 465 ASP D 477 REMARK 465 PHE D 478 REMARK 465 ALA D 479 REMARK 465 TYR E 209 REMARK 465 TYR E 210 REMARK 465 GLY E 211 REMARK 465 LEU E 212 REMARK 465 ASN E 213 REMARK 465 LEU E 214 REMARK 465 LEU E 215 REMARK 465 ILE E 216 REMARK 465 PRO E 217 REMARK 465 CYS E 218 REMARK 465 VAL E 219 REMARK 465 LEU E 220 REMARK 465 ILE E 221 REMARK 465 SER E 222 REMARK 465 ALA E 223 REMARK 465 LEU E 224 REMARK 465 ALA E 225 REMARK 465 LEU E 226 REMARK 465 LEU E 227 REMARK 465 VAL E 228 REMARK 465 PHE E 229 REMARK 465 LEU E 230 REMARK 465 LEU E 231 REMARK 465 PRO E 232 REMARK 465 ALA E 233 REMARK 465 ASP E 234 REMARK 465 SER E 235 REMARK 465 GLY E 236 REMARK 465 GLU E 237 REMARK 465 LYS E 238 REMARK 465 ILE E 239 REMARK 465 SER E 240 REMARK 465 LEU E 241 REMARK 465 GLY E 242 REMARK 465 ILE E 243 REMARK 465 THR E 244 REMARK 465 VAL E 245 REMARK 465 LEU E 246 REMARK 465 LEU E 247 REMARK 465 SER E 248 REMARK 465 LEU E 249 REMARK 465 THR E 250 REMARK 465 VAL E 251 REMARK 465 PHE E 252 REMARK 465 MET E 253 REMARK 465 LEU E 254 REMARK 465 LEU E 255 REMARK 465 VAL E 256 REMARK 465 ALA E 257 REMARK 465 GLU E 258 REMARK 465 ILE E 259 REMARK 465 MET E 260 REMARK 465 PRO E 261 REMARK 465 ALA E 262 REMARK 465 THR E 263 REMARK 465 SER E 264 REMARK 465 ASP E 265 REMARK 465 SER E 266 REMARK 465 VAL E 267 REMARK 465 PRO E 268 REMARK 465 LEU E 269 REMARK 465 ILE E 270 REMARK 465 ALA E 271 REMARK 465 GLN E 272 REMARK 465 TYR E 273 REMARK 465 PHE E 274 REMARK 465 ALA E 275 REMARK 465 SER E 276 REMARK 465 THR E 277 REMARK 465 MET E 278 REMARK 465 ILE E 279 REMARK 465 ILE E 280 REMARK 465 VAL E 281 REMARK 465 GLY E 282 REMARK 465 LEU E 283 REMARK 465 SER E 284 REMARK 465 VAL E 285 REMARK 465 VAL E 286 REMARK 465 VAL E 287 REMARK 465 THR E 288 REMARK 465 VAL E 289 REMARK 465 ILE E 290 REMARK 465 VAL E 291 REMARK 465 LEU E 292 REMARK 465 GLN E 293 REMARK 465 TYR E 294 REMARK 465 HIS E 295 REMARK 465 HIS E 296 REMARK 465 HIS E 297 REMARK 465 ASP E 298 REMARK 465 PRO E 299 REMARK 465 ASP E 300 REMARK 465 GLY E 301 REMARK 465 GLY E 302 REMARK 465 LYS E 303 REMARK 465 MET E 304 REMARK 465 PRO E 305 REMARK 465 LYS E 306 REMARK 465 TRP E 307 REMARK 465 THR E 308 REMARK 465 ARG E 309 REMARK 465 VAL E 310 REMARK 465 ILE E 311 REMARK 465 LEU E 312 REMARK 465 LEU E 313 REMARK 465 ASN E 314 REMARK 465 TRP E 315 REMARK 465 CYS E 316 REMARK 465 ALA E 317 REMARK 465 TRP E 318 REMARK 465 PHE E 319 REMARK 465 LEU E 320 REMARK 465 ARG E 321 REMARK 465 MET E 322 REMARK 465 LYS E 323 REMARK 465 ARG E 324 REMARK 465 PRO E 325 REMARK 465 GLY E 326 REMARK 465 GLU E 327 REMARK 465 ASP E 328 REMARK 465 LYS E 329 REMARK 465 VAL E 330 REMARK 465 ARG E 331 REMARK 465 PRO E 332 REMARK 465 ALA E 333 REMARK 465 CYS E 334 REMARK 465 GLN E 335 REMARK 465 HIS E 336 REMARK 465 LYS E 337 REMARK 465 GLN E 338 REMARK 465 ARG E 339 REMARK 465 ARG E 340 REMARK 465 CYS E 341 REMARK 465 SER E 342 REMARK 465 LEU E 343 REMARK 465 ALA E 344 REMARK 465 SER E 345 REMARK 465 VAL E 346 REMARK 465 GLU E 347 REMARK 465 MET E 348 REMARK 465 SER E 349 REMARK 465 ALA E 350 REMARK 465 VAL E 351 REMARK 465 ALA E 352 REMARK 465 PRO E 353 REMARK 465 PRO E 354 REMARK 465 PRO E 355 REMARK 465 ALA E 356 REMARK 465 SER E 357 REMARK 465 ASN E 358 REMARK 465 GLY E 359 REMARK 465 ASN E 360 REMARK 465 LEU E 361 REMARK 465 LEU E 362 REMARK 465 TYR E 363 REMARK 465 ILE E 364 REMARK 465 GLY E 365 REMARK 465 PHE E 366 REMARK 465 ARG E 367 REMARK 465 GLY E 368 REMARK 465 LEU E 369 REMARK 465 ASP E 370 REMARK 465 GLY E 371 REMARK 465 VAL E 372 REMARK 465 HIS E 373 REMARK 465 CYS E 374 REMARK 465 VAL E 375 REMARK 465 PRO E 376 REMARK 465 THR E 377 REMARK 465 PRO E 378 REMARK 465 ASP E 379 REMARK 465 SER E 380 REMARK 465 GLY E 381 REMARK 465 VAL E 382 REMARK 465 VAL E 383 REMARK 465 CYS E 384 REMARK 465 GLY E 385 REMARK 465 ARG E 386 REMARK 465 MET E 387 REMARK 465 ALA E 388 REMARK 465 CYS E 389 REMARK 465 SER E 390 REMARK 465 PRO E 391 REMARK 465 THR E 392 REMARK 465 HIS E 393 REMARK 465 ASP E 394 REMARK 465 GLU E 395 REMARK 465 HIS E 396 REMARK 465 LEU E 397 REMARK 465 LEU E 398 REMARK 465 HIS E 399 REMARK 465 GLY E 400 REMARK 465 GLY E 401 REMARK 465 GLN E 402 REMARK 465 PRO E 403 REMARK 465 PRO E 404 REMARK 465 GLU E 405 REMARK 465 GLY E 406 REMARK 465 ASP E 407 REMARK 465 PRO E 408 REMARK 465 ASP E 409 REMARK 465 LEU E 410 REMARK 465 ALA E 411 REMARK 465 LYS E 412 REMARK 465 ILE E 413 REMARK 465 LEU E 414 REMARK 465 GLU E 415 REMARK 465 GLU E 416 REMARK 465 VAL E 417 REMARK 465 ARG E 418 REMARK 465 TYR E 419 REMARK 465 ILE E 420 REMARK 465 ALA E 421 REMARK 465 ASN E 422 REMARK 465 ARG E 423 REMARK 465 PHE E 424 REMARK 465 ARG E 425 REMARK 465 CYS E 426 REMARK 465 GLN E 427 REMARK 465 ASP E 428 REMARK 465 GLU E 429 REMARK 465 SER E 430 REMARK 465 GLU E 431 REMARK 465 ALA E 432 REMARK 465 VAL E 433 REMARK 465 CYS E 434 REMARK 465 SER E 435 REMARK 465 GLU E 436 REMARK 465 TRP E 437 REMARK 465 LYS E 438 REMARK 465 PHE E 439 REMARK 465 ALA E 440 REMARK 465 ALA E 441 REMARK 465 CYS E 442 REMARK 465 VAL E 443 REMARK 465 VAL E 444 REMARK 465 ASP E 445 REMARK 465 ARG E 446 REMARK 465 LEU E 447 REMARK 465 CYS E 448 REMARK 465 LEU E 449 REMARK 465 MET E 450 REMARK 465 ALA E 451 REMARK 465 PHE E 452 REMARK 465 SER E 453 REMARK 465 VAL E 454 REMARK 465 PHE E 455 REMARK 465 THR E 456 REMARK 465 ILE E 457 REMARK 465 ILE E 458 REMARK 465 CYS E 459 REMARK 465 THR E 460 REMARK 465 ILE E 461 REMARK 465 GLY E 462 REMARK 465 ILE E 463 REMARK 465 LEU E 464 REMARK 465 MET E 465 REMARK 465 SER E 466 REMARK 465 ALA E 467 REMARK 465 PRO E 468 REMARK 465 ASN E 469 REMARK 465 PHE E 470 REMARK 465 VAL E 471 REMARK 465 GLU E 472 REMARK 465 ALA E 473 REMARK 465 VAL E 474 REMARK 465 SER E 475 REMARK 465 LYS E 476 REMARK 465 ASP E 477 REMARK 465 PHE E 478 REMARK 465 ALA E 479 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 LEU A 64 40.45 -108.96 REMARK 500 PHE A 99 -70.13 63.77 REMARK 500 SER A 111 -7.86 72.79 REMARK 500 TRP A 153 -3.91 65.92 REMARK 500 SER A 154 -50.64 -124.66 REMARK 500 ALA B 22 -9.16 71.16 REMARK 500 ASP B 88 52.73 -91.31 REMARK 500 ASN B 93 52.08 -91.14 REMARK 500 SER B 149 32.19 -140.89 REMARK 500 ILE B 178 67.31 -150.27 REMARK 500 ALA C 22 -5.21 77.69 REMARK 500 LEU C 64 40.09 -109.39 REMARK 500 ASP C 88 52.02 -91.17 REMARK 500 ASN C 93 52.15 -90.65 REMARK 500 SER C 111 -7.04 72.88 REMARK 500 SER C 149 32.73 -140.26 REMARK 500 ALA D 22 -3.58 76.42 REMARK 500 ASP D 24 -7.63 75.00 REMARK 500 LEU D 64 40.34 -109.49 REMARK 500 ASP D 88 56.21 -98.11 REMARK 500 SER D 111 -7.31 72.39 REMARK 500 ALA E 22 -6.33 73.28 REMARK 500 LEU E 64 40.23 -109.97 REMARK 500 VAL F 52 -56.40 -125.20 REMARK 500 VAL G 52 -57.68 -122.18 REMARK 500 ALA H 96 -179.72 -171.87 REMARK 500 VAL I 52 -60.19 -122.13 REMARK 500 GLN J 4 -8.66 74.26 REMARK 500 VAL J 52 -57.02 -125.54 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-53355 RELATED DB: EMDB REMARK 900 HUMAN ALPHA7 NICOTINIC RECEPTOR IN COMPLEX WITH THE F1 NANOBODY DBREF 9QTN A 1 479 UNP P36544 ACHA7_HUMAN 24 502 DBREF 9QTN B 1 479 UNP P36544 ACHA7_HUMAN 24 502 DBREF 9QTN C 1 479 UNP P36544 ACHA7_HUMAN 24 502 DBREF 9QTN D 1 479 UNP P36544 ACHA7_HUMAN 24 502 DBREF 9QTN E 1 479 UNP P36544 ACHA7_HUMAN 24 502 DBREF 9QTN F 2 132 PDB 9QTN 9QTN 2 132 DBREF 9QTN G 2 132 PDB 9QTN 9QTN 2 132 DBREF 9QTN H 2 132 PDB 9QTN 9QTN 2 132 DBREF 9QTN I 2 132 PDB 9QTN 9QTN 2 132 DBREF 9QTN J 2 132 PDB 9QTN 9QTN 2 132 SEQRES 1 A 479 GLU PHE GLN ARG LYS LEU TYR LYS GLU LEU VAL LYS ASN SEQRES 2 A 479 TYR ASN PRO LEU GLU ARG PRO VAL ALA ASN ASP SER GLN SEQRES 3 A 479 PRO LEU THR VAL TYR PHE SER LEU SER LEU LEU GLN ILE SEQRES 4 A 479 MET ASP VAL ASP GLU LYS ASN GLN VAL LEU THR THR ASN SEQRES 5 A 479 ILE TRP LEU GLN MET SER TRP THR ASP HIS TYR LEU GLN SEQRES 6 A 479 TRP ASN VAL SER GLU TYR PRO GLY VAL LYS THR VAL ARG SEQRES 7 A 479 PHE PRO ASP GLY GLN ILE TRP LYS PRO ASP ILE LEU LEU SEQRES 8 A 479 TYR ASN SER ALA ASP GLU ARG PHE ASP ALA THR PHE HIS SEQRES 9 A 479 THR ASN VAL LEU VAL ASN SER SER GLY HIS CYS GLN TYR SEQRES 10 A 479 LEU PRO PRO GLY ILE PHE LYS SER SER CYS TYR ILE ASP SEQRES 11 A 479 VAL ARG TRP PHE PRO PHE ASP VAL GLN HIS CYS LYS LEU SEQRES 12 A 479 LYS PHE GLY SER TRP SER TYR GLY GLY TRP SER LEU ASP SEQRES 13 A 479 LEU GLN MET GLN GLU ALA ASP ILE SER GLY TYR ILE PRO SEQRES 14 A 479 ASN GLY GLU TRP ASP LEU VAL GLY ILE PRO GLY LYS ARG SEQRES 15 A 479 SER GLU ARG PHE TYR GLU CYS CYS LYS GLU PRO TYR PRO SEQRES 16 A 479 ASP VAL THR PHE THR VAL THR MET ARG ARG ARG THR LEU SEQRES 17 A 479 TYR TYR GLY LEU ASN LEU LEU ILE PRO CYS VAL LEU ILE SEQRES 18 A 479 SER ALA LEU ALA LEU LEU VAL PHE LEU LEU PRO ALA ASP SEQRES 19 A 479 SER GLY GLU LYS ILE SER LEU GLY ILE THR VAL LEU LEU SEQRES 20 A 479 SER LEU THR VAL PHE MET LEU LEU VAL ALA GLU ILE MET SEQRES 21 A 479 PRO ALA THR SER ASP SER VAL PRO LEU ILE ALA GLN TYR SEQRES 22 A 479 PHE ALA SER THR MET ILE ILE VAL GLY LEU SER VAL VAL SEQRES 23 A 479 VAL THR VAL ILE VAL LEU GLN TYR HIS HIS HIS ASP PRO SEQRES 24 A 479 ASP GLY GLY LYS MET PRO LYS TRP THR ARG VAL ILE LEU SEQRES 25 A 479 LEU ASN TRP CYS ALA TRP PHE LEU ARG MET LYS ARG PRO SEQRES 26 A 479 GLY GLU ASP LYS VAL ARG PRO ALA CYS GLN HIS LYS GLN SEQRES 27 A 479 ARG ARG CYS SER LEU ALA SER VAL GLU MET SER ALA VAL SEQRES 28 A 479 ALA PRO PRO PRO ALA SER ASN GLY ASN LEU LEU TYR ILE SEQRES 29 A 479 GLY PHE ARG GLY LEU ASP GLY VAL HIS CYS VAL PRO THR SEQRES 30 A 479 PRO ASP SER GLY VAL VAL CYS GLY ARG MET ALA CYS SER SEQRES 31 A 479 PRO THR HIS ASP GLU HIS LEU LEU HIS GLY GLY GLN PRO SEQRES 32 A 479 PRO GLU GLY ASP PRO ASP LEU ALA LYS ILE LEU GLU GLU SEQRES 33 A 479 VAL ARG TYR ILE ALA ASN ARG PHE ARG CYS GLN ASP GLU SEQRES 34 A 479 SER GLU ALA VAL CYS SER GLU TRP LYS PHE ALA ALA CYS SEQRES 35 A 479 VAL VAL ASP ARG LEU CYS LEU MET ALA PHE SER VAL PHE SEQRES 36 A 479 THR ILE ILE CYS THR ILE GLY ILE LEU MET SER ALA PRO SEQRES 37 A 479 ASN PHE VAL GLU ALA VAL SER LYS ASP PHE ALA SEQRES 1 B 479 GLU PHE GLN ARG LYS LEU TYR LYS GLU LEU VAL LYS ASN SEQRES 2 B 479 TYR ASN PRO LEU GLU ARG PRO VAL ALA ASN ASP SER GLN SEQRES 3 B 479 PRO LEU THR VAL TYR PHE SER LEU SER LEU LEU GLN ILE SEQRES 4 B 479 MET ASP VAL ASP GLU LYS ASN GLN VAL LEU THR THR ASN SEQRES 5 B 479 ILE TRP LEU GLN MET SER TRP THR ASP HIS TYR LEU GLN SEQRES 6 B 479 TRP ASN VAL SER GLU TYR PRO GLY VAL LYS THR VAL ARG SEQRES 7 B 479 PHE PRO ASP GLY GLN ILE TRP LYS PRO ASP ILE LEU LEU SEQRES 8 B 479 TYR ASN SER ALA ASP GLU ARG PHE ASP ALA THR PHE HIS SEQRES 9 B 479 THR ASN VAL LEU VAL ASN SER SER GLY HIS CYS GLN TYR SEQRES 10 B 479 LEU PRO PRO GLY ILE PHE LYS SER SER CYS TYR ILE ASP SEQRES 11 B 479 VAL ARG TRP PHE PRO PHE ASP VAL GLN HIS CYS LYS LEU SEQRES 12 B 479 LYS PHE GLY SER TRP SER TYR GLY GLY TRP SER LEU ASP SEQRES 13 B 479 LEU GLN MET GLN GLU ALA ASP ILE SER GLY TYR ILE PRO SEQRES 14 B 479 ASN GLY GLU TRP ASP LEU VAL GLY ILE PRO GLY LYS ARG SEQRES 15 B 479 SER GLU ARG PHE TYR GLU CYS CYS LYS GLU PRO TYR PRO SEQRES 16 B 479 ASP VAL THR PHE THR VAL THR MET ARG ARG ARG THR LEU SEQRES 17 B 479 TYR TYR GLY LEU ASN LEU LEU ILE PRO CYS VAL LEU ILE SEQRES 18 B 479 SER ALA LEU ALA LEU LEU VAL PHE LEU LEU PRO ALA ASP SEQRES 19 B 479 SER GLY GLU LYS ILE SER LEU GLY ILE THR VAL LEU LEU SEQRES 20 B 479 SER LEU THR VAL PHE MET LEU LEU VAL ALA GLU ILE MET SEQRES 21 B 479 PRO ALA THR SER ASP SER VAL PRO LEU ILE ALA GLN TYR SEQRES 22 B 479 PHE ALA SER THR MET ILE ILE VAL GLY LEU SER VAL VAL SEQRES 23 B 479 VAL THR VAL ILE VAL LEU GLN TYR HIS HIS HIS ASP PRO SEQRES 24 B 479 ASP GLY GLY LYS MET PRO LYS TRP THR ARG VAL ILE LEU SEQRES 25 B 479 LEU ASN TRP CYS ALA TRP PHE LEU ARG MET LYS ARG PRO SEQRES 26 B 479 GLY GLU ASP LYS VAL ARG PRO ALA CYS GLN HIS LYS GLN SEQRES 27 B 479 ARG ARG CYS SER LEU ALA SER VAL GLU MET SER ALA VAL SEQRES 28 B 479 ALA PRO PRO PRO ALA SER ASN GLY ASN LEU LEU TYR ILE SEQRES 29 B 479 GLY PHE ARG GLY LEU ASP GLY VAL HIS CYS VAL PRO THR SEQRES 30 B 479 PRO ASP SER GLY VAL VAL CYS GLY ARG MET ALA CYS SER SEQRES 31 B 479 PRO THR HIS ASP GLU HIS LEU LEU HIS GLY GLY GLN PRO SEQRES 32 B 479 PRO GLU GLY ASP PRO ASP LEU ALA LYS ILE LEU GLU GLU SEQRES 33 B 479 VAL ARG TYR ILE ALA ASN ARG PHE ARG CYS GLN ASP GLU SEQRES 34 B 479 SER GLU ALA VAL CYS SER GLU TRP LYS PHE ALA ALA CYS SEQRES 35 B 479 VAL VAL ASP ARG LEU CYS LEU MET ALA PHE SER VAL PHE SEQRES 36 B 479 THR ILE ILE CYS THR ILE GLY ILE LEU MET SER ALA PRO SEQRES 37 B 479 ASN PHE VAL GLU ALA VAL SER LYS ASP PHE ALA SEQRES 1 C 479 GLU PHE GLN ARG LYS LEU TYR LYS GLU LEU VAL LYS ASN SEQRES 2 C 479 TYR ASN PRO LEU GLU ARG PRO VAL ALA ASN ASP SER GLN SEQRES 3 C 479 PRO LEU THR VAL TYR PHE SER LEU SER LEU LEU GLN ILE SEQRES 4 C 479 MET ASP VAL ASP GLU LYS ASN GLN VAL LEU THR THR ASN SEQRES 5 C 479 ILE TRP LEU GLN MET SER TRP THR ASP HIS TYR LEU GLN SEQRES 6 C 479 TRP ASN VAL SER GLU TYR PRO GLY VAL LYS THR VAL ARG SEQRES 7 C 479 PHE PRO ASP GLY GLN ILE TRP LYS PRO ASP ILE LEU LEU SEQRES 8 C 479 TYR ASN SER ALA ASP GLU ARG PHE ASP ALA THR PHE HIS SEQRES 9 C 479 THR ASN VAL LEU VAL ASN SER SER GLY HIS CYS GLN TYR SEQRES 10 C 479 LEU PRO PRO GLY ILE PHE LYS SER SER CYS TYR ILE ASP SEQRES 11 C 479 VAL ARG TRP PHE PRO PHE ASP VAL GLN HIS CYS LYS LEU SEQRES 12 C 479 LYS PHE GLY SER TRP SER TYR GLY GLY TRP SER LEU ASP SEQRES 13 C 479 LEU GLN MET GLN GLU ALA ASP ILE SER GLY TYR ILE PRO SEQRES 14 C 479 ASN GLY GLU TRP ASP LEU VAL GLY ILE PRO GLY LYS ARG SEQRES 15 C 479 SER GLU ARG PHE TYR GLU CYS CYS LYS GLU PRO TYR PRO SEQRES 16 C 479 ASP VAL THR PHE THR VAL THR MET ARG ARG ARG THR LEU SEQRES 17 C 479 TYR TYR GLY LEU ASN LEU LEU ILE PRO CYS VAL LEU ILE SEQRES 18 C 479 SER ALA LEU ALA LEU LEU VAL PHE LEU LEU PRO ALA ASP SEQRES 19 C 479 SER GLY GLU LYS ILE SER LEU GLY ILE THR VAL LEU LEU SEQRES 20 C 479 SER LEU THR VAL PHE MET LEU LEU VAL ALA GLU ILE MET SEQRES 21 C 479 PRO ALA THR SER ASP SER VAL PRO LEU ILE ALA GLN TYR SEQRES 22 C 479 PHE ALA SER THR MET ILE ILE VAL GLY LEU SER VAL VAL SEQRES 23 C 479 VAL THR VAL ILE VAL LEU GLN TYR HIS HIS HIS ASP PRO SEQRES 24 C 479 ASP GLY GLY LYS MET PRO LYS TRP THR ARG VAL ILE LEU SEQRES 25 C 479 LEU ASN TRP CYS ALA TRP PHE LEU ARG MET LYS ARG PRO SEQRES 26 C 479 GLY GLU ASP LYS VAL ARG PRO ALA CYS GLN HIS LYS GLN SEQRES 27 C 479 ARG ARG CYS SER LEU ALA SER VAL GLU MET SER ALA VAL SEQRES 28 C 479 ALA PRO PRO PRO ALA SER ASN GLY ASN LEU LEU TYR ILE SEQRES 29 C 479 GLY PHE ARG GLY LEU ASP GLY VAL HIS CYS VAL PRO THR SEQRES 30 C 479 PRO ASP SER GLY VAL VAL CYS GLY ARG MET ALA CYS SER SEQRES 31 C 479 PRO THR HIS ASP GLU HIS LEU LEU HIS GLY GLY GLN PRO SEQRES 32 C 479 PRO GLU GLY ASP PRO ASP LEU ALA LYS ILE LEU GLU GLU SEQRES 33 C 479 VAL ARG TYR ILE ALA ASN ARG PHE ARG CYS GLN ASP GLU SEQRES 34 C 479 SER GLU ALA VAL CYS SER GLU TRP LYS PHE ALA ALA CYS SEQRES 35 C 479 VAL VAL ASP ARG LEU CYS LEU MET ALA PHE SER VAL PHE SEQRES 36 C 479 THR ILE ILE CYS THR ILE GLY ILE LEU MET SER ALA PRO SEQRES 37 C 479 ASN PHE VAL GLU ALA VAL SER LYS ASP PHE ALA SEQRES 1 D 479 GLU PHE GLN ARG LYS LEU TYR LYS GLU LEU VAL LYS ASN SEQRES 2 D 479 TYR ASN PRO LEU GLU ARG PRO VAL ALA ASN ASP SER GLN SEQRES 3 D 479 PRO LEU THR VAL TYR PHE SER LEU SER LEU LEU GLN ILE SEQRES 4 D 479 MET ASP VAL ASP GLU LYS ASN GLN VAL LEU THR THR ASN SEQRES 5 D 479 ILE TRP LEU GLN MET SER TRP THR ASP HIS TYR LEU GLN SEQRES 6 D 479 TRP ASN VAL SER GLU TYR PRO GLY VAL LYS THR VAL ARG SEQRES 7 D 479 PHE PRO ASP GLY GLN ILE TRP LYS PRO ASP ILE LEU LEU SEQRES 8 D 479 TYR ASN SER ALA ASP GLU ARG PHE ASP ALA THR PHE HIS SEQRES 9 D 479 THR ASN VAL LEU VAL ASN SER SER GLY HIS CYS GLN TYR SEQRES 10 D 479 LEU PRO PRO GLY ILE PHE LYS SER SER CYS TYR ILE ASP SEQRES 11 D 479 VAL ARG TRP PHE PRO PHE ASP VAL GLN HIS CYS LYS LEU SEQRES 12 D 479 LYS PHE GLY SER TRP SER TYR GLY GLY TRP SER LEU ASP SEQRES 13 D 479 LEU GLN MET GLN GLU ALA ASP ILE SER GLY TYR ILE PRO SEQRES 14 D 479 ASN GLY GLU TRP ASP LEU VAL GLY ILE PRO GLY LYS ARG SEQRES 15 D 479 SER GLU ARG PHE TYR GLU CYS CYS LYS GLU PRO TYR PRO SEQRES 16 D 479 ASP VAL THR PHE THR VAL THR MET ARG ARG ARG THR LEU SEQRES 17 D 479 TYR TYR GLY LEU ASN LEU LEU ILE PRO CYS VAL LEU ILE SEQRES 18 D 479 SER ALA LEU ALA LEU LEU VAL PHE LEU LEU PRO ALA ASP SEQRES 19 D 479 SER GLY GLU LYS ILE SER LEU GLY ILE THR VAL LEU LEU SEQRES 20 D 479 SER LEU THR VAL PHE MET LEU LEU VAL ALA GLU ILE MET SEQRES 21 D 479 PRO ALA THR SER ASP SER VAL PRO LEU ILE ALA GLN TYR SEQRES 22 D 479 PHE ALA SER THR MET ILE ILE VAL GLY LEU SER VAL VAL SEQRES 23 D 479 VAL THR VAL ILE VAL LEU GLN TYR HIS HIS HIS ASP PRO SEQRES 24 D 479 ASP GLY GLY LYS MET PRO LYS TRP THR ARG VAL ILE LEU SEQRES 25 D 479 LEU ASN TRP CYS ALA TRP PHE LEU ARG MET LYS ARG PRO SEQRES 26 D 479 GLY GLU ASP LYS VAL ARG PRO ALA CYS GLN HIS LYS GLN SEQRES 27 D 479 ARG ARG CYS SER LEU ALA SER VAL GLU MET SER ALA VAL SEQRES 28 D 479 ALA PRO PRO PRO ALA SER ASN GLY ASN LEU LEU TYR ILE SEQRES 29 D 479 GLY PHE ARG GLY LEU ASP GLY VAL HIS CYS VAL PRO THR SEQRES 30 D 479 PRO ASP SER GLY VAL VAL CYS GLY ARG MET ALA CYS SER SEQRES 31 D 479 PRO THR HIS ASP GLU HIS LEU LEU HIS GLY GLY GLN PRO SEQRES 32 D 479 PRO GLU GLY ASP PRO ASP LEU ALA LYS ILE LEU GLU GLU SEQRES 33 D 479 VAL ARG TYR ILE ALA ASN ARG PHE ARG CYS GLN ASP GLU SEQRES 34 D 479 SER GLU ALA VAL CYS SER GLU TRP LYS PHE ALA ALA CYS SEQRES 35 D 479 VAL VAL ASP ARG LEU CYS LEU MET ALA PHE SER VAL PHE SEQRES 36 D 479 THR ILE ILE CYS THR ILE GLY ILE LEU MET SER ALA PRO SEQRES 37 D 479 ASN PHE VAL GLU ALA VAL SER LYS ASP PHE ALA SEQRES 1 E 479 GLU PHE GLN ARG LYS LEU TYR LYS GLU LEU VAL LYS ASN SEQRES 2 E 479 TYR ASN PRO LEU GLU ARG PRO VAL ALA ASN ASP SER GLN SEQRES 3 E 479 PRO LEU THR VAL TYR PHE SER LEU SER LEU LEU GLN ILE SEQRES 4 E 479 MET ASP VAL ASP GLU LYS ASN GLN VAL LEU THR THR ASN SEQRES 5 E 479 ILE TRP LEU GLN MET SER TRP THR ASP HIS TYR LEU GLN SEQRES 6 E 479 TRP ASN VAL SER GLU TYR PRO GLY VAL LYS THR VAL ARG SEQRES 7 E 479 PHE PRO ASP GLY GLN ILE TRP LYS PRO ASP ILE LEU LEU SEQRES 8 E 479 TYR ASN SER ALA ASP GLU ARG PHE ASP ALA THR PHE HIS SEQRES 9 E 479 THR ASN VAL LEU VAL ASN SER SER GLY HIS CYS GLN TYR SEQRES 10 E 479 LEU PRO PRO GLY ILE PHE LYS SER SER CYS TYR ILE ASP SEQRES 11 E 479 VAL ARG TRP PHE PRO PHE ASP VAL GLN HIS CYS LYS LEU SEQRES 12 E 479 LYS PHE GLY SER TRP SER TYR GLY GLY TRP SER LEU ASP SEQRES 13 E 479 LEU GLN MET GLN GLU ALA ASP ILE SER GLY TYR ILE PRO SEQRES 14 E 479 ASN GLY GLU TRP ASP LEU VAL GLY ILE PRO GLY LYS ARG SEQRES 15 E 479 SER GLU ARG PHE TYR GLU CYS CYS LYS GLU PRO TYR PRO SEQRES 16 E 479 ASP VAL THR PHE THR VAL THR MET ARG ARG ARG THR LEU SEQRES 17 E 479 TYR TYR GLY LEU ASN LEU LEU ILE PRO CYS VAL LEU ILE SEQRES 18 E 479 SER ALA LEU ALA LEU LEU VAL PHE LEU LEU PRO ALA ASP SEQRES 19 E 479 SER GLY GLU LYS ILE SER LEU GLY ILE THR VAL LEU LEU SEQRES 20 E 479 SER LEU THR VAL PHE MET LEU LEU VAL ALA GLU ILE MET SEQRES 21 E 479 PRO ALA THR SER ASP SER VAL PRO LEU ILE ALA GLN TYR SEQRES 22 E 479 PHE ALA SER THR MET ILE ILE VAL GLY LEU SER VAL VAL SEQRES 23 E 479 VAL THR VAL ILE VAL LEU GLN TYR HIS HIS HIS ASP PRO SEQRES 24 E 479 ASP GLY GLY LYS MET PRO LYS TRP THR ARG VAL ILE LEU SEQRES 25 E 479 LEU ASN TRP CYS ALA TRP PHE LEU ARG MET LYS ARG PRO SEQRES 26 E 479 GLY GLU ASP LYS VAL ARG PRO ALA CYS GLN HIS LYS GLN SEQRES 27 E 479 ARG ARG CYS SER LEU ALA SER VAL GLU MET SER ALA VAL SEQRES 28 E 479 ALA PRO PRO PRO ALA SER ASN GLY ASN LEU LEU TYR ILE SEQRES 29 E 479 GLY PHE ARG GLY LEU ASP GLY VAL HIS CYS VAL PRO THR SEQRES 30 E 479 PRO ASP SER GLY VAL VAL CYS GLY ARG MET ALA CYS SER SEQRES 31 E 479 PRO THR HIS ASP GLU HIS LEU LEU HIS GLY GLY GLN PRO SEQRES 32 E 479 PRO GLU GLY ASP PRO ASP LEU ALA LYS ILE LEU GLU GLU SEQRES 33 E 479 VAL ARG TYR ILE ALA ASN ARG PHE ARG CYS GLN ASP GLU SEQRES 34 E 479 SER GLU ALA VAL CYS SER GLU TRP LYS PHE ALA ALA CYS SEQRES 35 E 479 VAL VAL ASP ARG LEU CYS LEU MET ALA PHE SER VAL PHE SEQRES 36 E 479 THR ILE ILE CYS THR ILE GLY ILE LEU MET SER ALA PRO SEQRES 37 E 479 ASN PHE VAL GLU ALA VAL SER LYS ASP PHE ALA SEQRES 1 F 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 F 131 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA PRO GLY SEQRES 3 F 131 ILE THR LEU SER ARG TYR GLY MET TYR GLY MET GLY TRP SEQRES 4 F 131 PHE ARG GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA SEQRES 5 F 131 ALA ILE THR TRP SER GLY GLY GLN THR TYR TYR GLN ASP SEQRES 6 F 131 SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA SEQRES 7 F 131 LYS LYS LEU THR PHE LEU GLN MET ASN SER LEU LYS PRO SEQRES 8 F 131 GLU ASP THR ALA VAL TYR TYR CYS ALA ALA ASP GLY ASP SEQRES 9 F 131 ARG PHE TYR PRO GLU PRO VAL VAL ASP ASP ASN ALA TYR SEQRES 10 F 131 LYS PHE TRP GLY GLN GLY THR GLN VAL THR VAL SER SER SEQRES 11 F 131 ALA SEQRES 1 G 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 G 131 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA PRO GLY SEQRES 3 G 131 ILE THR LEU SER ARG TYR GLY MET TYR GLY MET GLY TRP SEQRES 4 G 131 PHE ARG GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA SEQRES 5 G 131 ALA ILE THR TRP SER GLY GLY GLN THR TYR TYR GLN ASP SEQRES 6 G 131 SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA SEQRES 7 G 131 LYS LYS LEU THR PHE LEU GLN MET ASN SER LEU LYS PRO SEQRES 8 G 131 GLU ASP THR ALA VAL TYR TYR CYS ALA ALA ASP GLY ASP SEQRES 9 G 131 ARG PHE TYR PRO GLU PRO VAL VAL ASP ASP ASN ALA TYR SEQRES 10 G 131 LYS PHE TRP GLY GLN GLY THR GLN VAL THR VAL SER SER SEQRES 11 G 131 ALA SEQRES 1 H 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 H 131 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA PRO GLY SEQRES 3 H 131 ILE THR LEU SER ARG TYR GLY MET TYR GLY MET GLY TRP SEQRES 4 H 131 PHE ARG GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA SEQRES 5 H 131 ALA ILE THR TRP SER GLY GLY GLN THR TYR TYR GLN ASP SEQRES 6 H 131 SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA SEQRES 7 H 131 LYS LYS LEU THR PHE LEU GLN MET ASN SER LEU LYS PRO SEQRES 8 H 131 GLU ASP THR ALA VAL TYR TYR CYS ALA ALA ASP GLY ASP SEQRES 9 H 131 ARG PHE TYR PRO GLU PRO VAL VAL ASP ASP ASN ALA TYR SEQRES 10 H 131 LYS PHE TRP GLY GLN GLY THR GLN VAL THR VAL SER SER SEQRES 11 H 131 ALA SEQRES 1 I 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 I 131 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA PRO GLY SEQRES 3 I 131 ILE THR LEU SER ARG TYR GLY MET TYR GLY MET GLY TRP SEQRES 4 I 131 PHE ARG GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA SEQRES 5 I 131 ALA ILE THR TRP SER GLY GLY GLN THR TYR TYR GLN ASP SEQRES 6 I 131 SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA SEQRES 7 I 131 LYS LYS LEU THR PHE LEU GLN MET ASN SER LEU LYS PRO SEQRES 8 I 131 GLU ASP THR ALA VAL TYR TYR CYS ALA ALA ASP GLY ASP SEQRES 9 I 131 ARG PHE TYR PRO GLU PRO VAL VAL ASP ASP ASN ALA TYR SEQRES 10 I 131 LYS PHE TRP GLY GLN GLY THR GLN VAL THR VAL SER SER SEQRES 11 I 131 ALA SEQRES 1 J 131 GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL GLN SEQRES 2 J 131 ALA GLY GLY SER LEU ARG LEU SER CYS ALA ALA PRO GLY SEQRES 3 J 131 ILE THR LEU SER ARG TYR GLY MET TYR GLY MET GLY TRP SEQRES 4 J 131 PHE ARG GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA SEQRES 5 J 131 ALA ILE THR TRP SER GLY GLY GLN THR TYR TYR GLN ASP SEQRES 6 J 131 SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA SEQRES 7 J 131 LYS LYS LEU THR PHE LEU GLN MET ASN SER LEU LYS PRO SEQRES 8 J 131 GLU ASP THR ALA VAL TYR TYR CYS ALA ALA ASP GLY ASP SEQRES 9 J 131 ARG PHE TYR PRO GLU PRO VAL VAL ASP ASP ASN ALA TYR SEQRES 10 J 131 LYS PHE TRP GLY GLN GLY THR GLN VAL THR VAL SER SER SEQRES 11 J 131 ALA HET NAG K 1 14 HET NAG K 2 14 HET BMA K 3 11 HET MAN K 4 11 HET MAN K 5 11 HET NAG L 1 14 HET NAG L 2 14 HET FUC L 3 10 HET NAG M 1 14 HET NAG M 2 14 HET FUC M 3 10 HET NAG N 1 14 HET NAG N 2 14 HET FUC N 3 10 HET NAG O 1 14 HET NAG O 2 14 HET BMA O 3 11 HET MAN O 4 11 HET FUC O 5 10 HET NAG P 1 14 HET NAG P 2 14 HET BMA P 3 11 HET MAN P 4 11 HET NAG P 5 14 HET NAG Q 1 14 HET NAG Q 2 14 HET BMA Q 3 11 HET MAN Q 4 11 HET MAN Q 5 11 HET NAG R 1 14 HET NAG R 2 14 HET FUC R 3 10 HET NAG S 1 14 HET NAG S 2 14 HET BMA S 3 11 HET NAG T 1 14 HET NAG T 2 14 HET BMA T 3 11 HET MAN T 4 11 HET MAN T 5 11 HET NAG U 1 14 HET NAG U 2 14 HET FUC U 3 10 HET NAG V 1 14 HET NAG V 2 14 HET BMA V 3 11 HET MAN V 4 11 HET NAG W 1 14 HET NAG W 2 14 HET BMA W 3 11 HET MAN W 4 11 HET MAN W 5 11 HET NAG X 1 14 HET NAG X 2 14 HET FUC X 3 10 HET NAG Y 1 14 HET NAG Y 2 14 HET BMA Y 3 11 HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE HETNAM BMA BETA-D-MANNOPYRANOSE HETNAM MAN ALPHA-D-MANNOPYRANOSE HETNAM FUC ALPHA-L-FUCOPYRANOSE HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA- HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO- HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE HETSYN FUC ALPHA-L-FUCOSE; 6-DEOXY-ALPHA-L-GALACTOPYRANOSE; L- HETSYN 2 FUC FUCOSE; FUCOSE FORMUL 11 NAG 31(C8 H15 N O6) FORMUL 11 BMA 9(C6 H12 O6) FORMUL 11 MAN 11(C6 H12 O6) FORMUL 12 FUC 7(C6 H12 O5) FORMUL 26 HOH *103(H2 O) HELIX 1 AA1 GLU A 1 VAL A 11 1 11 HELIX 2 AA2 ASN A 67 TYR A 71 5 5 HELIX 3 AA3 PHE B 2 VAL B 11 1 10 HELIX 4 AA4 PHE C 2 LEU C 10 1 9 HELIX 5 AA5 PHE D 2 LEU D 10 1 9 HELIX 6 AA6 PHE E 2 VAL E 11 1 10 HELIX 7 AA7 THR F 29 GLY F 34 1 6 HELIX 8 AA8 LYS F 91 THR F 95 5 5 HELIX 9 AA9 ASP F 114 ASN F 116 5 3 HELIX 10 AB1 THR G 29 GLY G 34 1 6 HELIX 11 AB2 ASP G 114 TYR G 118 5 5 HELIX 12 AB3 THR H 29 GLY H 34 1 6 HELIX 13 AB4 ASP H 114 TYR H 118 5 5 HELIX 14 AB5 THR I 29 GLY I 34 1 6 HELIX 15 AB6 ASP I 114 TYR I 118 5 5 HELIX 16 AB7 THR J 29 GLY J 34 1 6 HELIX 17 AB8 LYS J 91 THR J 95 5 5 HELIX 18 AB9 ASP J 114 TYR J 118 5 5 SHEET 1 AA1 5 VAL A 77 PHE A 79 0 SHEET 2 AA1 5 VAL A 107 VAL A 109 -1 O VAL A 107 N PHE A 79 SHEET 3 AA1 5 SER A 112 TYR A 117 -1 O GLN A 116 N LEU A 108 SHEET 4 AA1 5 VAL A 48 GLN A 65 -1 N ASP A 61 O GLY A 113 SHEET 5 AA1 5 PRO A 120 SER A 126 -1 O SER A 125 N LEU A 49 SHEET 1 AA2 6 VAL A 77 PHE A 79 0 SHEET 2 AA2 6 VAL A 107 VAL A 109 -1 O VAL A 107 N PHE A 79 SHEET 3 AA2 6 SER A 112 TYR A 117 -1 O GLN A 116 N LEU A 108 SHEET 4 AA2 6 VAL A 48 GLN A 65 -1 N ASP A 61 O GLY A 113 SHEET 5 AA2 6 LEU A 28 ASP A 43 -1 N GLN A 38 O ASN A 52 SHEET 6 AA2 6 LEU A 155 MET A 159 1 O GLN A 158 N PHE A 32 SHEET 1 AA3 4 ILE A 89 LEU A 91 0 SHEET 2 AA3 4 VAL A 138 SER A 147 -1 O GLY A 146 N LEU A 90 SHEET 3 AA3 4 PRO A 193 ARG A 205 -1 O VAL A 197 N PHE A 145 SHEET 4 AA3 4 TRP A 173 GLY A 177 -1 N ASP A 174 O ARG A 204 SHEET 1 AA4 4 ILE A 89 LEU A 91 0 SHEET 2 AA4 4 VAL A 138 SER A 147 -1 O GLY A 146 N LEU A 90 SHEET 3 AA4 4 PRO A 193 ARG A 205 -1 O VAL A 197 N PHE A 145 SHEET 4 AA4 4 GLY A 180 PHE A 186 -1 N LYS A 181 O THR A 198 SHEET 1 AA5 5 THR B 76 PHE B 79 0 SHEET 2 AA5 5 VAL B 107 ASN B 110 -1 O VAL B 109 N VAL B 77 SHEET 3 AA5 5 SER B 112 TYR B 117 -1 O GLN B 116 N LEU B 108 SHEET 4 AA5 5 VAL B 48 GLN B 65 -1 N ASP B 61 O GLY B 113 SHEET 5 AA5 5 PRO B 120 SER B 126 -1 O GLY B 121 N ILE B 53 SHEET 1 AA6 6 THR B 76 PHE B 79 0 SHEET 2 AA6 6 VAL B 107 ASN B 110 -1 O VAL B 109 N VAL B 77 SHEET 3 AA6 6 SER B 112 TYR B 117 -1 O GLN B 116 N LEU B 108 SHEET 4 AA6 6 VAL B 48 GLN B 65 -1 N ASP B 61 O GLY B 113 SHEET 5 AA6 6 LEU B 28 ASP B 43 -1 N GLN B 38 O ASN B 52 SHEET 6 AA6 6 LEU B 155 MET B 159 1 O GLN B 158 N VAL B 30 SHEET 1 AA7 4 ILE B 89 LEU B 91 0 SHEET 2 AA7 4 VAL B 138 SER B 147 -1 O GLY B 146 N LEU B 90 SHEET 3 AA7 4 PRO B 193 ARG B 205 -1 O VAL B 197 N PHE B 145 SHEET 4 AA7 4 TRP B 173 GLY B 177 -1 N ASP B 174 O ARG B 204 SHEET 1 AA8 4 ILE B 89 LEU B 91 0 SHEET 2 AA8 4 VAL B 138 SER B 147 -1 O GLY B 146 N LEU B 90 SHEET 3 AA8 4 PRO B 193 ARG B 205 -1 O VAL B 197 N PHE B 145 SHEET 4 AA8 4 GLY B 180 PHE B 186 -1 N LYS B 181 O THR B 198 SHEET 1 AA9 6 VAL C 77 PHE C 79 0 SHEET 2 AA9 6 VAL C 107 VAL C 109 -1 O VAL C 107 N PHE C 79 SHEET 3 AA9 6 SER C 112 TYR C 117 -1 O GLN C 116 N LEU C 108 SHEET 4 AA9 6 GLN C 56 GLN C 65 -1 N ASP C 61 O GLY C 113 SHEET 5 AA9 6 LEU C 28 SER C 33 -1 N TYR C 31 O SER C 58 SHEET 6 AA9 6 LEU C 155 MET C 159 1 O GLN C 158 N VAL C 30 SHEET 1 AB1 3 LEU C 36 ASP C 43 0 SHEET 2 AB1 3 VAL C 48 TRP C 54 -1 O ASN C 52 N GLN C 38 SHEET 3 AB1 3 PRO C 120 SER C 126 -1 O SER C 125 N LEU C 49 SHEET 1 AB2 4 ILE C 89 LEU C 91 0 SHEET 2 AB2 4 VAL C 138 SER C 147 -1 O GLY C 146 N LEU C 90 SHEET 3 AB2 4 PRO C 193 ARG C 205 -1 O VAL C 197 N PHE C 145 SHEET 4 AB2 4 TRP C 173 GLY C 177 -1 N ASP C 174 O ARG C 204 SHEET 1 AB3 4 ILE C 89 LEU C 91 0 SHEET 2 AB3 4 VAL C 138 SER C 147 -1 O GLY C 146 N LEU C 90 SHEET 3 AB3 4 PRO C 193 ARG C 205 -1 O VAL C 197 N PHE C 145 SHEET 4 AB3 4 GLY C 180 PHE C 186 -1 N LYS C 181 O THR C 198 SHEET 1 AB4 5 VAL D 77 PHE D 79 0 SHEET 2 AB4 5 VAL D 107 VAL D 109 -1 O VAL D 107 N PHE D 79 SHEET 3 AB4 5 SER D 112 TYR D 117 -1 O GLN D 116 N LEU D 108 SHEET 4 AB4 5 VAL D 48 GLN D 65 -1 N ASP D 61 O GLY D 113 SHEET 5 AB4 5 PRO D 120 SER D 126 -1 O GLY D 121 N ILE D 53 SHEET 1 AB5 6 VAL D 77 PHE D 79 0 SHEET 2 AB5 6 VAL D 107 VAL D 109 -1 O VAL D 107 N PHE D 79 SHEET 3 AB5 6 SER D 112 TYR D 117 -1 O GLN D 116 N LEU D 108 SHEET 4 AB5 6 VAL D 48 GLN D 65 -1 N ASP D 61 O GLY D 113 SHEET 5 AB5 6 LEU D 28 ASP D 43 -1 N GLN D 38 O ASN D 52 SHEET 6 AB5 6 LEU D 155 MET D 159 1 O ASP D 156 N VAL D 30 SHEET 1 AB6 4 ILE D 89 LEU D 91 0 SHEET 2 AB6 4 VAL D 138 SER D 147 -1 O GLY D 146 N LEU D 90 SHEET 3 AB6 4 PRO D 193 ARG D 205 -1 O VAL D 197 N PHE D 145 SHEET 4 AB6 4 TRP D 173 GLY D 177 -1 N ASP D 174 O ARG D 204 SHEET 1 AB7 4 ILE D 89 LEU D 91 0 SHEET 2 AB7 4 VAL D 138 SER D 147 -1 O GLY D 146 N LEU D 90 SHEET 3 AB7 4 PRO D 193 ARG D 205 -1 O VAL D 197 N PHE D 145 SHEET 4 AB7 4 GLY D 180 PHE D 186 -1 N LYS D 181 O THR D 198 SHEET 1 AB8 5 THR E 76 PHE E 79 0 SHEET 2 AB8 5 VAL E 107 ASN E 110 -1 O VAL E 107 N PHE E 79 SHEET 3 AB8 5 SER E 112 TYR E 117 -1 O GLN E 116 N LEU E 108 SHEET 4 AB8 5 VAL E 48 GLN E 65 -1 N ASP E 61 O GLY E 113 SHEET 5 AB8 5 PRO E 120 SER E 126 -1 O GLY E 121 N ILE E 53 SHEET 1 AB9 6 THR E 76 PHE E 79 0 SHEET 2 AB9 6 VAL E 107 ASN E 110 -1 O VAL E 107 N PHE E 79 SHEET 3 AB9 6 SER E 112 TYR E 117 -1 O GLN E 116 N LEU E 108 SHEET 4 AB9 6 VAL E 48 GLN E 65 -1 N ASP E 61 O GLY E 113 SHEET 5 AB9 6 LEU E 28 ASP E 43 -1 N GLN E 38 O ASN E 52 SHEET 6 AB9 6 LEU E 155 MET E 159 1 O GLN E 158 N VAL E 30 SHEET 1 AC1 4 ILE E 89 LEU E 91 0 SHEET 2 AC1 4 VAL E 138 SER E 147 -1 O GLY E 146 N LEU E 90 SHEET 3 AC1 4 PRO E 193 ARG E 205 -1 O VAL E 197 N PHE E 145 SHEET 4 AC1 4 TRP E 173 GLY E 177 -1 N ASP E 174 O ARG E 204 SHEET 1 AC2 4 ILE E 89 LEU E 91 0 SHEET 2 AC2 4 VAL E 138 SER E 147 -1 O GLY E 146 N LEU E 90 SHEET 3 AC2 4 PRO E 193 ARG E 205 -1 O VAL E 197 N PHE E 145 SHEET 4 AC2 4 GLY E 180 PHE E 186 -1 N LYS E 181 O THR E 198 SHEET 1 AC3 4 VAL F 6 SER F 8 0 SHEET 2 AC3 4 SER F 18 ALA F 24 -1 O ALA F 24 N VAL F 6 SHEET 3 AC3 4 LEU F 82 ASN F 88 -1 O LEU F 85 N LEU F 21 SHEET 4 AC3 4 PHE F 72 ASP F 77 -1 N THR F 73 O GLN F 86 SHEET 1 AC4 6 LEU F 12 VAL F 13 0 SHEET 2 AC4 6 THR F 125 VAL F 129 1 O THR F 128 N VAL F 13 SHEET 3 AC4 6 ALA F 96 ASP F 103 -1 N TYR F 98 O THR F 125 SHEET 4 AC4 6 MET F 38 GLN F 43 -1 N GLY F 39 O ALA F 101 SHEET 5 AC4 6 ARG F 49 ILE F 55 -1 O ALA F 53 N TRP F 40 SHEET 6 AC4 6 THR F 62 TYR F 64 -1 O TYR F 63 N ALA F 54 SHEET 1 AC5 4 LEU F 12 VAL F 13 0 SHEET 2 AC5 4 THR F 125 VAL F 129 1 O THR F 128 N VAL F 13 SHEET 3 AC5 4 ALA F 96 ASP F 103 -1 N TYR F 98 O THR F 125 SHEET 4 AC5 4 TYR F 118 TRP F 121 -1 O PHE F 120 N ALA F 102 SHEET 1 AC6 4 VAL G 6 SER G 8 0 SHEET 2 AC6 4 SER G 18 ALA G 24 -1 O SER G 22 N SER G 8 SHEET 3 AC6 4 LEU G 82 ASN G 88 -1 O LEU G 85 N LEU G 21 SHEET 4 AC6 4 PHE G 72 ASP G 77 -1 N THR G 73 O GLN G 86 SHEET 1 AC7 6 GLY G 11 GLN G 14 0 SHEET 2 AC7 6 THR G 125 SER G 130 1 O THR G 128 N GLY G 11 SHEET 3 AC7 6 ALA G 96 ALA G 102 -1 N TYR G 98 O THR G 125 SHEET 4 AC7 6 MET G 38 GLN G 43 -1 N GLN G 43 O VAL G 97 SHEET 5 AC7 6 GLU G 50 ILE G 55 -1 O ALA G 53 N TRP G 40 SHEET 6 AC7 6 THR G 62 TYR G 64 -1 O TYR G 63 N ALA G 54 SHEET 1 AC8 4 GLY G 11 GLN G 14 0 SHEET 2 AC8 4 THR G 125 SER G 130 1 O THR G 128 N GLY G 11 SHEET 3 AC8 4 ALA G 96 ALA G 102 -1 N TYR G 98 O THR G 125 SHEET 4 AC8 4 PHE G 120 TRP G 121 -1 O PHE G 120 N ALA G 102 SHEET 1 AC9 4 VAL H 6 SER H 8 0 SHEET 2 AC9 4 SER H 18 ALA H 24 -1 O ALA H 24 N VAL H 6 SHEET 3 AC9 4 LEU H 82 ASN H 88 -1 O MET H 87 N LEU H 19 SHEET 4 AC9 4 PHE H 72 ASP H 77 -1 N THR H 73 O GLN H 86 SHEET 1 AD1 6 GLY H 11 VAL H 13 0 SHEET 2 AD1 6 THR H 125 VAL H 129 1 O THR H 128 N GLY H 11 SHEET 3 AD1 6 ALA H 96 ALA H 102 -1 N TYR H 98 O THR H 125 SHEET 4 AD1 6 MET H 38 GLN H 43 -1 N GLY H 39 O ALA H 101 SHEET 5 AD1 6 ARG H 49 ILE H 55 -1 O GLU H 50 N ARG H 42 SHEET 6 AD1 6 THR H 62 TYR H 64 -1 O TYR H 63 N ALA H 54 SHEET 1 AD2 4 GLY H 11 VAL H 13 0 SHEET 2 AD2 4 THR H 125 VAL H 129 1 O THR H 128 N GLY H 11 SHEET 3 AD2 4 ALA H 96 ALA H 102 -1 N TYR H 98 O THR H 125 SHEET 4 AD2 4 PHE H 120 TRP H 121 -1 O PHE H 120 N ALA H 102 SHEET 1 AD3 4 VAL I 6 GLU I 7 0 SHEET 2 AD3 4 SER I 18 ALA I 24 -1 O ALA I 24 N VAL I 6 SHEET 3 AD3 4 LEU I 82 ASN I 88 -1 O LEU I 85 N LEU I 21 SHEET 4 AD3 4 PHE I 72 ASP I 77 -1 N ASP I 77 O LEU I 82 SHEET 1 AD4 2 VAL I 13 GLN I 14 0 SHEET 2 AD4 2 VAL I 129 SER I 130 1 O SER I 130 N VAL I 13 SHEET 1 AD5 5 THR I 62 TYR I 64 0 SHEET 2 AD5 5 GLU I 50 ILE I 55 -1 N ALA I 54 O TYR I 63 SHEET 3 AD5 5 MET I 38 GLN I 43 -1 N ARG I 42 O GLU I 50 SHEET 4 AD5 5 ALA I 96 ALA I 102 -1 O ALA I 101 N GLY I 39 SHEET 5 AD5 5 PHE I 120 TRP I 121 -1 O PHE I 120 N ALA I 102 SHEET 1 AD6 5 THR I 62 TYR I 64 0 SHEET 2 AD6 5 GLU I 50 ILE I 55 -1 N ALA I 54 O TYR I 63 SHEET 3 AD6 5 MET I 38 GLN I 43 -1 N ARG I 42 O GLU I 50 SHEET 4 AD6 5 ALA I 96 ALA I 102 -1 O ALA I 101 N GLY I 39 SHEET 5 AD6 5 THR I 125 VAL I 127 -1 O THR I 125 N TYR I 98 SHEET 1 AD7 4 VAL J 6 SER J 8 0 SHEET 2 AD7 4 SER J 18 ALA J 24 -1 O ALA J 24 N VAL J 6 SHEET 3 AD7 4 LEU J 82 ASN J 88 -1 O MET J 87 N LEU J 19 SHEET 4 AD7 4 PHE J 72 ASP J 77 -1 N ASP J 77 O LEU J 82 SHEET 1 AD8 6 LEU J 12 GLN J 14 0 SHEET 2 AD8 6 THR J 125 SER J 130 1 O SER J 130 N VAL J 13 SHEET 3 AD8 6 ALA J 96 ALA J 102 -1 N TYR J 98 O THR J 125 SHEET 4 AD8 6 MET J 38 GLN J 43 -1 N GLY J 39 O ALA J 101 SHEET 5 AD8 6 GLU J 50 ILE J 55 -1 O ILE J 55 N MET J 38 SHEET 6 AD8 6 THR J 62 TYR J 64 -1 O TYR J 63 N ALA J 54 SHEET 1 AD9 4 LEU J 12 GLN J 14 0 SHEET 2 AD9 4 THR J 125 SER J 130 1 O SER J 130 N VAL J 13 SHEET 3 AD9 4 ALA J 96 ALA J 102 -1 N TYR J 98 O THR J 125 SHEET 4 AD9 4 PHE J 120 TRP J 121 -1 O PHE J 120 N ALA J 102 SSBOND 1 CYS A 127 CYS A 141 1555 1555 2.04 SSBOND 2 CYS B 127 CYS B 141 1555 1555 2.04 SSBOND 3 CYS C 127 CYS C 141 1555 1555 2.03 SSBOND 4 CYS D 127 CYS D 141 1555 1555 2.04 SSBOND 5 CYS E 127 CYS E 141 1555 1555 2.04 SSBOND 6 CYS F 23 CYS F 100 1555 1555 2.03 SSBOND 7 CYS G 23 CYS G 100 1555 1555 2.03 SSBOND 8 CYS H 23 CYS H 100 1555 1555 2.03 SSBOND 9 CYS I 23 CYS I 100 1555 1555 2.03 SSBOND 10 CYS J 23 CYS J 100 1555 1555 2.03 LINK ND2 ASN A 23 C1 NAG M 1 1555 1555 1.44 LINK ND2 ASN A 67 C1 NAG L 1 1555 1555 1.44 LINK ND2 ASN A 110 C1 NAG K 1 1555 1555 1.43 LINK ND2 ASN B 23 C1 NAG O 1 1555 1555 1.45 LINK ND2 ASN B 67 C1 NAG N 1 1555 1555 1.44 LINK ND2 ASN B 110 C1 NAG P 1 1555 1555 1.44 LINK ND2 ASN C 23 C1 NAG S 1 1555 1555 1.47 LINK ND2 ASN C 67 C1 NAG R 1 1555 1555 1.44 LINK ND2 ASN C 110 C1 NAG Q 1 1555 1555 1.44 LINK ND2 ASN D 23 C1 NAG V 1 1555 1555 1.44 LINK ND2 ASN D 67 C1 NAG U 1 1555 1555 1.44 LINK ND2 ASN D 110 C1 NAG T 1 1555 1555 1.43 LINK ND2 ASN E 23 C1 NAG Y 1 1555 1555 1.45 LINK ND2 ASN E 67 C1 NAG X 1 1555 1555 1.44 LINK ND2 ASN E 110 C1 NAG W 1 1555 1555 1.44 LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.44 LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.44 LINK O3 BMA K 3 C1 MAN K 4 1555 1555 1.45 LINK O6 BMA K 3 C1 MAN K 5 1555 1555 1.44 LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.44 LINK O6 NAG L 1 C1 FUC L 3 1555 1555 1.44 LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.44 LINK O6 NAG M 1 C1 FUC M 3 1555 1555 1.45 LINK O4 NAG N 1 C1 NAG N 2 1555 1555 1.44 LINK O6 NAG N 1 C1 FUC N 3 1555 1555 1.44 LINK O4 NAG O 1 C1 NAG O 2 1555 1555 1.44 LINK O6 NAG O 1 C1 FUC O 5 1555 1555 1.45 LINK O4 NAG O 2 C1 BMA O 3 1555 1555 1.45 LINK O6 BMA O 3 C1 MAN O 4 1555 1555 1.46 LINK O4 NAG P 1 C1 NAG P 2 1555 1555 1.45 LINK O4 NAG P 2 C1 BMA P 3 1555 1555 1.45 LINK O3 BMA P 3 C1 MAN P 4 1555 1555 1.45 LINK O2 MAN P 4 C1 NAG P 5 1555 1555 1.46 LINK O4 NAG Q 1 C1 NAG Q 2 1555 1555 1.44 LINK O4 NAG Q 2 C1 BMA Q 3 1555 1555 1.44 LINK O3 BMA Q 3 C1 MAN Q 4 1555 1555 1.45 LINK O6 BMA Q 3 C1 MAN Q 5 1555 1555 1.44 LINK O4 NAG R 1 C1 NAG R 2 1555 1555 1.44 LINK O6 NAG R 1 C1 FUC R 3 1555 1555 1.44 LINK O4 NAG S 1 C1 NAG S 2 1555 1555 1.48 LINK O4 NAG S 2 C1 BMA S 3 1555 1555 1.45 LINK O4 NAG T 1 C1 NAG T 2 1555 1555 1.44 LINK O4 NAG T 2 C1 BMA T 3 1555 1555 1.45 LINK O3 BMA T 3 C1 MAN T 4 1555 1555 1.45 LINK O6 BMA T 3 C1 MAN T 5 1555 1555 1.44 LINK O4 NAG U 1 C1 NAG U 2 1555 1555 1.44 LINK O6 NAG U 1 C1 FUC U 3 1555 1555 1.44 LINK O4 NAG V 1 C1 NAG V 2 1555 1555 1.44 LINK O4 NAG V 2 C1 BMA V 3 1555 1555 1.45 LINK O3 BMA V 3 C1 MAN V 4 1555 1555 1.45 LINK O4 NAG W 1 C1 NAG W 2 1555 1555 1.45 LINK O4 NAG W 2 C1 BMA W 3 1555 1555 1.45 LINK O3 BMA W 3 C1 MAN W 4 1555 1555 1.45 LINK O6 BMA W 3 C1 MAN W 5 1555 1555 1.44 LINK O4 NAG X 1 C1 NAG X 2 1555 1555 1.44 LINK O6 NAG X 1 C1 FUC X 3 1555 1555 1.44 LINK O4 NAG Y 1 C1 NAG Y 2 1555 1555 1.45 LINK O4 NAG Y 2 C1 BMA Y 3 1555 1555 1.45 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000