HEADER MEMBRANE PROTEIN 25-APR-25 9UOK TITLE STRUCTURE OF THE COMPLEX OF LGR4_ECD WITH NORRIN COMPND MOL_ID: 1; COMPND 2 MOLECULE: MB52; COMPND 3 CHAIN: A; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR COMPND 7 4; COMPND 8 CHAIN: C; COMPND 9 SYNONYM: G-PROTEIN COUPLED RECEPTOR 48; COMPND 10 ENGINEERED: YES; COMPND 11 MOL_ID: 3; COMPND 12 MOLECULE: NORRIN,IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN; COMPND 13 CHAIN: E, F; COMPND 14 SYNONYM: NORRIE DISEASE PROTEIN,X-LINKED EXUDATIVE VITREORETINOPATHY COMPND 15 2 PROTEIN,IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN NIE; COMPND 16 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: CAMELUS FERUS; SOURCE 3 ORGANISM_TAXID: 419612; SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 5 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 8 ORGANISM_COMMON: HUMAN; SOURCE 9 ORGANISM_TAXID: 9606; SOURCE 10 GENE: LGR4, GPR48; SOURCE 11 EXPRESSION_SYSTEM: HOMO SAPIENS; SOURCE 12 EXPRESSION_SYSTEM_TAXID: 9606; SOURCE 13 MOL_ID: 3; SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 15 ORGANISM_COMMON: HUMAN; SOURCE 16 ORGANISM_TAXID: 9606; SOURCE 17 GENE: NDP, EVR2; SOURCE 18 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 7108 KEYWDS LGR4 NORRIN, MEMBRANE PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR Y.GENG,F.Z.HU,H.R.QIAO REVDAT 1 16-JUL-25 9UOK 0 JRNL AUTH Y.GENG,F.Z.HU,H.R.QIAO JRNL TITL STRUCTURE OF THE COMPLEX OF LGR4_ECD WITH NORRIN JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 3.05 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : NULL REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.050 REMARK 3 NUMBER OF PARTICLES : 119661 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING ONLY REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9UOK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 28-APR-25. REMARK 100 THE DEPOSITION ID IS D_1300058849. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : STRUCTURE OF THE COMPLEX OF REMARK 245 LGR4_ECD WITH NORRIN REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : FEI TALOS ARCTICA REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 7000.00 REMARK 245 ILLUMINATION MODE : OTHER REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC REMARK 350 SOFTWARE USED: PISA REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, F REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A -18 REMARK 465 LYS A -17 REMARK 465 LYS A -16 REMARK 465 ILE A -15 REMARK 465 TRP A -14 REMARK 465 LEU A -13 REMARK 465 ALA A -12 REMARK 465 LEU A -11 REMARK 465 ALA A -10 REMARK 465 GLY A -9 REMARK 465 LEU A -8 REMARK 465 VAL A -7 REMARK 465 LEU A -6 REMARK 465 ALA A -5 REMARK 465 PHE A -4 REMARK 465 SER A -3 REMARK 465 ALA A -2 REMARK 465 SER A -1 REMARK 465 ALA A 0 REMARK 465 GLN A 1 REMARK 465 VAL A 2 REMARK 465 GLN A 3 REMARK 465 LEU A 4 REMARK 465 VAL A 5 REMARK 465 GLU A 6 REMARK 465 SER A 7 REMARK 465 GLY A 8 REMARK 465 GLY A 9 REMARK 465 GLY A 10 REMARK 465 LEU A 11 REMARK 465 VAL A 12 REMARK 465 GLN A 13 REMARK 465 THR A 14 REMARK 465 LYS A 15 REMARK 465 THR A 16 REMARK 465 THR A 17 REMARK 465 THR A 18 REMARK 465 SER A 19 REMARK 465 VAL A 20 REMARK 465 ILE A 21 REMARK 465 ASP A 22 REMARK 465 THR A 23 REMARK 465 THR A 24 REMARK 465 ASN A 25 REMARK 465 ASP A 26 REMARK 465 ALA A 27 REMARK 465 GLN A 28 REMARK 465 ASN A 29 REMARK 465 LEU A 30 REMARK 465 LEU A 31 REMARK 465 THR A 32 REMARK 465 GLN A 33 REMARK 465 ALA A 34 REMARK 465 GLN A 35 REMARK 465 THR A 36 REMARK 465 ILE A 37 REMARK 465 VAL A 38 REMARK 465 ASN A 39 REMARK 465 THR A 40 REMARK 465 LEU A 41 REMARK 465 LYS A 42 REMARK 465 ASP A 43 REMARK 465 TYR A 44 REMARK 465 CYS A 45 REMARK 465 PRO A 46 REMARK 465 ILE A 47 REMARK 465 LEU A 48 REMARK 465 ILE A 49 REMARK 465 ALA A 50 REMARK 465 LYS A 51 REMARK 465 SER A 52 REMARK 465 SER A 53 REMARK 465 SER A 54 REMARK 465 SER A 55 REMARK 465 ASN A 56 REMARK 465 GLY A 57 REMARK 465 GLY A 58 REMARK 465 THR A 59 REMARK 465 ASN A 60 REMARK 465 ASN A 61 REMARK 465 ALA A 62 REMARK 465 ASN A 63 REMARK 465 THR A 64 REMARK 465 PRO A 65 REMARK 465 SER A 66 REMARK 465 TRP A 67 REMARK 465 GLN A 68 REMARK 465 THR A 69 REMARK 465 ALA A 70 REMARK 465 GLY A 71 REMARK 465 GLY A 72 REMARK 465 GLY A 73 REMARK 465 LYS A 74 REMARK 465 ASN A 75 REMARK 465 SER A 76 REMARK 465 CYS A 77 REMARK 465 ALA A 78 REMARK 465 THR A 79 REMARK 465 PHE A 80 REMARK 465 GLY A 81 REMARK 465 ALA A 82 REMARK 465 GLU A 83 REMARK 465 PHE A 84 REMARK 465 SER A 85 REMARK 465 ALA A 86 REMARK 465 ALA A 87 REMARK 465 SER A 88 REMARK 465 ASP A 89 REMARK 465 MET A 90 REMARK 465 ILE A 91 REMARK 465 ASN A 92 REMARK 465 ASN A 93 REMARK 465 ALA A 94 REMARK 465 GLN A 95 REMARK 465 LYS A 96 REMARK 465 ILE A 97 REMARK 465 VAL A 98 REMARK 465 GLN A 99 REMARK 465 GLU A 100 REMARK 465 THR A 101 REMARK 465 GLN A 102 REMARK 465 GLN A 103 REMARK 465 LEU A 104 REMARK 465 SER A 105 REMARK 465 ALA A 106 REMARK 465 ASN A 107 REMARK 465 GLN A 108 REMARK 465 PRO A 109 REMARK 465 LYS A 110 REMARK 465 ASN A 111 REMARK 465 ILE A 112 REMARK 465 THR A 113 REMARK 465 GLN A 114 REMARK 465 PRO A 115 REMARK 465 HIS A 116 REMARK 465 ASN A 117 REMARK 465 LEU A 118 REMARK 465 ASN A 119 REMARK 465 LEU A 120 REMARK 465 ASN A 121 REMARK 465 SER A 122 REMARK 465 PRO A 123 REMARK 465 SER A 124 REMARK 465 SER A 125 REMARK 465 LEU A 126 REMARK 465 THR A 127 REMARK 465 ALA A 128 REMARK 465 LEU A 129 REMARK 465 ALA A 130 REMARK 465 GLN A 131 REMARK 465 LYS A 132 REMARK 465 MET A 133 REMARK 465 LEU A 134 REMARK 465 LYS A 135 REMARK 465 ASN A 136 REMARK 465 ALA A 137 REMARK 465 GLN A 138 REMARK 465 SER A 139 REMARK 465 GLN A 140 REMARK 465 ALA A 141 REMARK 465 GLU A 142 REMARK 465 ILE A 143 REMARK 465 LEU A 144 REMARK 465 LYS A 145 REMARK 465 LEU A 146 REMARK 465 ALA A 147 REMARK 465 ASN A 148 REMARK 465 GLN A 149 REMARK 465 VAL A 150 REMARK 465 GLU A 151 REMARK 465 SER A 152 REMARK 465 ASP A 153 REMARK 465 PHE A 154 REMARK 465 ASN A 155 REMARK 465 LYS A 156 REMARK 465 LEU A 157 REMARK 465 SER A 158 REMARK 465 SER A 159 REMARK 465 GLY A 160 REMARK 465 HIS A 161 REMARK 465 LEU A 162 REMARK 465 LYS A 163 REMARK 465 ASP A 164 REMARK 465 TYR A 165 REMARK 465 ILE A 166 REMARK 465 GLY A 167 REMARK 465 LYS A 168 REMARK 465 CYS A 169 REMARK 465 ASP A 170 REMARK 465 ALA A 171 REMARK 465 SER A 172 REMARK 465 ALA A 173 REMARK 465 ILE A 174 REMARK 465 SER A 175 REMARK 465 SER A 176 REMARK 465 ALA A 177 REMARK 465 ASN A 178 REMARK 465 MET A 179 REMARK 465 THR A 180 REMARK 465 MET A 181 REMARK 465 GLN A 182 REMARK 465 ASN A 183 REMARK 465 GLN A 184 REMARK 465 LYS A 185 REMARK 465 ASN A 186 REMARK 465 ASN A 187 REMARK 465 TRP A 188 REMARK 465 GLY A 189 REMARK 465 ASN A 190 REMARK 465 GLY A 191 REMARK 465 CYS A 192 REMARK 465 ALA A 193 REMARK 465 GLY A 194 REMARK 465 VAL A 195 REMARK 465 GLU A 196 REMARK 465 GLU A 197 REMARK 465 THR A 198 REMARK 465 GLN A 199 REMARK 465 SER A 200 REMARK 465 LEU A 201 REMARK 465 LEU A 202 REMARK 465 LYS A 203 REMARK 465 THR A 204 REMARK 465 SER A 205 REMARK 465 ALA A 206 REMARK 465 ALA A 207 REMARK 465 ASP A 208 REMARK 465 PHE A 209 REMARK 465 ASN A 210 REMARK 465 ASN A 211 REMARK 465 GLN A 212 REMARK 465 THR A 213 REMARK 465 PRO A 214 REMARK 465 GLN A 215 REMARK 465 ILE A 216 REMARK 465 ASN A 217 REMARK 465 GLN A 218 REMARK 465 ALA A 219 REMARK 465 GLN A 220 REMARK 465 ASN A 221 REMARK 465 LEU A 222 REMARK 465 ALA A 223 REMARK 465 ASN A 224 REMARK 465 THR A 225 REMARK 465 LEU A 226 REMARK 465 ILE A 227 REMARK 465 GLN A 228 REMARK 465 GLU A 229 REMARK 465 LEU A 230 REMARK 465 GLY A 231 REMARK 465 ASN A 232 REMARK 465 ASN A 233 REMARK 465 PRO A 234 REMARK 465 PHE A 235 REMARK 465 ARG A 236 REMARK 465 ALA A 237 REMARK 465 SER A 238 REMARK 465 GLY A 239 REMARK 465 GLY A 240 REMARK 465 GLY A 241 REMARK 465 SER A 242 REMARK 465 GLY A 243 REMARK 465 GLY A 244 REMARK 465 GLY A 245 REMARK 465 GLY A 246 REMARK 465 SER A 247 REMARK 465 GLY A 248 REMARK 465 LYS A 249 REMARK 465 LEU A 250 REMARK 465 SER A 251 REMARK 465 ASP A 252 REMARK 465 THR A 253 REMARK 465 TYR A 254 REMARK 465 GLU A 255 REMARK 465 GLN A 256 REMARK 465 LEU A 257 REMARK 465 SER A 258 REMARK 465 ARG A 259 REMARK 465 LEU A 260 REMARK 465 LEU A 261 REMARK 465 THR A 262 REMARK 465 ASN A 263 REMARK 465 ASP A 264 REMARK 465 ASN A 265 REMARK 465 GLY A 266 REMARK 465 THR A 267 REMARK 465 ASN A 268 REMARK 465 SER A 269 REMARK 465 LYS A 270 REMARK 465 THR A 271 REMARK 465 SER A 272 REMARK 465 ALA A 273 REMARK 465 GLN A 274 REMARK 465 ALA A 275 REMARK 465 ILE A 276 REMARK 465 ASN A 277 REMARK 465 GLN A 278 REMARK 465 ALA A 279 REMARK 465 VAL A 280 REMARK 465 ASN A 281 REMARK 465 ASN A 282 REMARK 465 LEU A 283 REMARK 465 ASN A 284 REMARK 465 GLU A 285 REMARK 465 ARG A 286 REMARK 465 ALA A 287 REMARK 465 LYS A 288 REMARK 465 THR A 289 REMARK 465 LEU A 290 REMARK 465 ALA A 291 REMARK 465 GLY A 292 REMARK 465 GLY A 293 REMARK 465 THR A 294 REMARK 465 THR A 295 REMARK 465 ASN A 296 REMARK 465 SER A 297 REMARK 465 PRO A 298 REMARK 465 ALA A 299 REMARK 465 TYR A 300 REMARK 465 GLN A 301 REMARK 465 ALA A 302 REMARK 465 THR A 303 REMARK 465 LEU A 304 REMARK 465 LEU A 305 REMARK 465 ALA A 306 REMARK 465 LEU A 307 REMARK 465 ARG A 308 REMARK 465 SER A 309 REMARK 465 VAL A 310 REMARK 465 LEU A 311 REMARK 465 GLY A 312 REMARK 465 LEU A 313 REMARK 465 TRP A 314 REMARK 465 ASN A 315 REMARK 465 SER A 316 REMARK 465 MET A 317 REMARK 465 GLY A 318 REMARK 465 TYR A 319 REMARK 465 ALA A 320 REMARK 465 VAL A 321 REMARK 465 ILE A 322 REMARK 465 CYS A 323 REMARK 465 GLY A 324 REMARK 465 GLY A 325 REMARK 465 TYR A 326 REMARK 465 THR A 327 REMARK 465 LYS A 328 REMARK 465 SER A 329 REMARK 465 PRO A 330 REMARK 465 GLY A 331 REMARK 465 GLU A 332 REMARK 465 ASN A 333 REMARK 465 ASN A 334 REMARK 465 GLN A 335 REMARK 465 LYS A 336 REMARK 465 ASP A 337 REMARK 465 PHE A 338 REMARK 465 HIS A 339 REMARK 465 TYR A 340 REMARK 465 THR A 341 REMARK 465 ASP A 342 REMARK 465 GLU A 343 REMARK 465 ASN A 344 REMARK 465 GLY A 345 REMARK 465 ASN A 346 REMARK 465 GLY A 347 REMARK 465 THR A 348 REMARK 465 THR A 349 REMARK 465 ILE A 350 REMARK 465 ASN A 351 REMARK 465 CYS A 352 REMARK 465 GLY A 353 REMARK 465 GLY A 354 REMARK 465 SER A 355 REMARK 465 THR A 356 REMARK 465 ASN A 357 REMARK 465 SER A 358 REMARK 465 ASN A 359 REMARK 465 GLY A 360 REMARK 465 THR A 361 REMARK 465 HIS A 362 REMARK 465 SER A 363 REMARK 465 TYR A 364 REMARK 465 ASN A 365 REMARK 465 GLY A 366 REMARK 465 THR A 367 REMARK 465 ASN A 368 REMARK 465 THR A 369 REMARK 465 LEU A 370 REMARK 465 LYS A 371 REMARK 465 ALA A 372 REMARK 465 ASP A 373 REMARK 465 LYS A 374 REMARK 465 ASN A 375 REMARK 465 VAL A 376 REMARK 465 SER A 377 REMARK 465 LEU A 378 REMARK 465 SER A 379 REMARK 465 ILE A 380 REMARK 465 GLU A 381 REMARK 465 GLN A 382 REMARK 465 TYR A 383 REMARK 465 GLU A 384 REMARK 465 LYS A 385 REMARK 465 ILE A 386 REMARK 465 HIS A 387 REMARK 465 GLU A 388 REMARK 465 ALA A 389 REMARK 465 TYR A 390 REMARK 465 GLN A 391 REMARK 465 ILE A 392 REMARK 465 LEU A 393 REMARK 465 SER A 394 REMARK 465 LYS A 395 REMARK 465 ALA A 396 REMARK 465 LEU A 397 REMARK 465 LYS A 398 REMARK 465 GLN A 399 REMARK 465 ALA A 400 REMARK 465 GLY A 401 REMARK 465 LEU A 402 REMARK 465 ALA A 403 REMARK 465 PRO A 404 REMARK 465 LEU A 405 REMARK 465 ASN A 406 REMARK 465 SER A 407 REMARK 465 LYS A 408 REMARK 465 GLY A 409 REMARK 465 GLU A 410 REMARK 465 LYS A 411 REMARK 465 LEU A 412 REMARK 465 GLU A 413 REMARK 465 ALA A 414 REMARK 465 HIS A 415 REMARK 465 VAL A 416 REMARK 465 THR A 417 REMARK 465 THR A 418 REMARK 465 SER A 419 REMARK 465 LYS A 420 REMARK 465 TYR A 421 REMARK 465 HIS A 532 REMARK 465 HIS A 533 REMARK 465 HIS A 534 REMARK 465 HIS A 535 REMARK 465 HIS A 536 REMARK 465 HIS A 537 REMARK 465 MET C 9 REMARK 465 LYS C 10 REMARK 465 THR C 11 REMARK 465 ILE C 12 REMARK 465 ILE C 13 REMARK 465 ALA C 14 REMARK 465 LEU C 15 REMARK 465 SER C 16 REMARK 465 TYR C 17 REMARK 465 ILE C 18 REMARK 465 PHE C 19 REMARK 465 CYS C 20 REMARK 465 LEU C 21 REMARK 465 VAL C 22 REMARK 465 PHE C 23 REMARK 465 ALA C 24 REMARK 465 ALA C 25 REMARK 465 PRO C 26 REMARK 465 PRO C 27 REMARK 465 LEU C 28 REMARK 465 CYS C 29 REMARK 465 TRP C 474 REMARK 465 GLY C 475 REMARK 465 CYS C 476 REMARK 465 ASP C 477 REMARK 465 SER C 478 REMARK 465 TYR C 479 REMARK 465 ALA C 480 REMARK 465 ASN C 481 REMARK 465 LEU C 482 REMARK 465 ASN C 483 REMARK 465 THR C 484 REMARK 465 GLU C 485 REMARK 465 ASP C 486 REMARK 465 ASN C 487 REMARK 465 SER C 488 REMARK 465 LEU C 489 REMARK 465 GLN C 490 REMARK 465 ASP C 491 REMARK 465 HIS C 492 REMARK 465 SER C 493 REMARK 465 VAL C 494 REMARK 465 ALA C 495 REMARK 465 GLN C 496 REMARK 465 GLU C 497 REMARK 465 LYS C 498 REMARK 465 GLY C 499 REMARK 465 THR C 500 REMARK 465 ALA C 501 REMARK 465 ASP C 502 REMARK 465 ALA C 503 REMARK 465 ALA C 504 REMARK 465 ASN C 505 REMARK 465 VAL C 506 REMARK 465 THR C 507 REMARK 465 SER C 508 REMARK 465 THR C 509 REMARK 465 LEU C 510 REMARK 465 GLU C 511 REMARK 465 ASN C 512 REMARK 465 GLU C 513 REMARK 465 GLU C 514 REMARK 465 HIS C 515 REMARK 465 SER C 516 REMARK 465 GLN C 517 REMARK 465 ILE C 518 REMARK 465 ILE C 519 REMARK 465 ILE C 520 REMARK 465 HIS C 521 REMARK 465 CYS C 522 REMARK 465 THR C 523 REMARK 465 PRO C 524 REMARK 465 SER C 525 REMARK 465 THR C 526 REMARK 465 GLY C 527 REMARK 465 ALA C 528 REMARK 465 PHE C 529 REMARK 465 LYS C 530 REMARK 465 PRO C 531 REMARK 465 CYS C 532 REMARK 465 GLU C 533 REMARK 465 TYR C 534 REMARK 465 LEU C 535 REMARK 465 LEU C 536 REMARK 465 GLY C 537 REMARK 465 SER C 538 REMARK 465 TRP C 539 REMARK 465 MET C 540 REMARK 465 ILE C 541 REMARK 465 ARG C 542 REMARK 465 LEU C 543 REMARK 465 THR C 544 REMARK 465 VAL C 545 REMARK 465 TRP C 546 REMARK 465 PHE C 547 REMARK 465 ILE C 548 REMARK 465 PHE C 549 REMARK 465 LEU C 550 REMARK 465 VAL C 551 REMARK 465 ALA C 552 REMARK 465 LEU C 553 REMARK 465 PHE C 554 REMARK 465 PHE C 555 REMARK 465 ASN C 556 REMARK 465 LEU C 557 REMARK 465 LEU C 558 REMARK 465 VAL C 559 REMARK 465 ILE C 560 REMARK 465 LEU C 561 REMARK 465 THR C 562 REMARK 465 THR C 563 REMARK 465 PHE C 564 REMARK 465 ALA C 565 REMARK 465 SER C 566 REMARK 465 CYS C 567 REMARK 465 THR C 568 REMARK 465 SER C 569 REMARK 465 LEU C 570 REMARK 465 PRO C 571 REMARK 465 SER C 572 REMARK 465 SER C 573 REMARK 465 LYS C 574 REMARK 465 LEU C 575 REMARK 465 PHE C 576 REMARK 465 ILE C 577 REMARK 465 GLY C 578 REMARK 465 LEU C 579 REMARK 465 ILE C 580 REMARK 465 SER C 581 REMARK 465 VAL C 582 REMARK 465 SER C 583 REMARK 465 ASN C 584 REMARK 465 LEU C 585 REMARK 465 PHE C 586 REMARK 465 MET C 587 REMARK 465 GLY C 588 REMARK 465 ILE C 589 REMARK 465 TYR C 590 REMARK 465 THR C 591 REMARK 465 GLY C 592 REMARK 465 ILE C 593 REMARK 465 LEU C 594 REMARK 465 THR C 595 REMARK 465 PHE C 596 REMARK 465 LEU C 597 REMARK 465 ASP C 598 REMARK 465 ALA C 599 REMARK 465 VAL C 600 REMARK 465 SER C 601 REMARK 465 TRP C 602 REMARK 465 GLY C 603 REMARK 465 ARG C 604 REMARK 465 PHE C 605 REMARK 465 ALA C 606 REMARK 465 GLU C 607 REMARK 465 PHE C 608 REMARK 465 GLY C 609 REMARK 465 ILE C 610 REMARK 465 TRP C 611 REMARK 465 TRP C 612 REMARK 465 GLU C 613 REMARK 465 THR C 614 REMARK 465 GLY C 615 REMARK 465 SER C 616 REMARK 465 GLY C 617 REMARK 465 CYS C 618 REMARK 465 LYS C 619 REMARK 465 VAL C 620 REMARK 465 ALA C 621 REMARK 465 GLY C 622 REMARK 465 PHE C 623 REMARK 465 LEU C 624 REMARK 465 ALA C 625 REMARK 465 VAL C 626 REMARK 465 PHE C 627 REMARK 465 SER C 628 REMARK 465 SER C 629 REMARK 465 GLU C 630 REMARK 465 SER C 631 REMARK 465 ALA C 632 REMARK 465 ILE C 633 REMARK 465 PHE C 634 REMARK 465 LEU C 635 REMARK 465 LEU C 636 REMARK 465 MET C 637 REMARK 465 LEU C 638 REMARK 465 ALA C 639 REMARK 465 THR C 640 REMARK 465 VAL C 641 REMARK 465 GLU C 642 REMARK 465 ARG C 643 REMARK 465 SER C 644 REMARK 465 LEU C 645 REMARK 465 SER C 646 REMARK 465 ALA C 647 REMARK 465 LYS C 648 REMARK 465 ASP C 649 REMARK 465 ILE C 650 REMARK 465 MET C 651 REMARK 465 LYS C 652 REMARK 465 ASN C 653 REMARK 465 GLY C 654 REMARK 465 LYS C 655 REMARK 465 SER C 656 REMARK 465 ASN C 657 REMARK 465 HIS C 658 REMARK 465 LEU C 659 REMARK 465 LYS C 660 REMARK 465 GLN C 661 REMARK 465 PHE C 662 REMARK 465 ARG C 663 REMARK 465 VAL C 664 REMARK 465 ALA C 665 REMARK 465 ALA C 666 REMARK 465 LEU C 667 REMARK 465 LEU C 668 REMARK 465 ALA C 669 REMARK 465 PHE C 670 REMARK 465 LEU C 671 REMARK 465 GLY C 672 REMARK 465 ALA C 673 REMARK 465 THR C 674 REMARK 465 VAL C 675 REMARK 465 ALA C 676 REMARK 465 GLY C 677 REMARK 465 CYS C 678 REMARK 465 PHE C 679 REMARK 465 PRO C 680 REMARK 465 LEU C 681 REMARK 465 PHE C 682 REMARK 465 HIS C 683 REMARK 465 ARG C 684 REMARK 465 GLY C 685 REMARK 465 GLU C 686 REMARK 465 TYR C 687 REMARK 465 SER C 688 REMARK 465 ALA C 689 REMARK 465 SER C 690 REMARK 465 PRO C 691 REMARK 465 LEU C 692 REMARK 465 CYS C 693 REMARK 465 LEU C 694 REMARK 465 PRO C 695 REMARK 465 PHE C 696 REMARK 465 PRO C 697 REMARK 465 THR C 698 REMARK 465 GLY C 699 REMARK 465 GLU C 700 REMARK 465 THR C 701 REMARK 465 PRO C 702 REMARK 465 SER C 703 REMARK 465 LEU C 704 REMARK 465 GLY C 705 REMARK 465 PHE C 706 REMARK 465 THR C 707 REMARK 465 VAL C 708 REMARK 465 THR C 709 REMARK 465 LEU C 710 REMARK 465 VAL C 711 REMARK 465 LEU C 712 REMARK 465 LEU C 713 REMARK 465 ASN C 714 REMARK 465 SER C 715 REMARK 465 LEU C 716 REMARK 465 ALA C 717 REMARK 465 PHE C 718 REMARK 465 LEU C 719 REMARK 465 LEU C 720 REMARK 465 MET C 721 REMARK 465 ALA C 722 REMARK 465 VAL C 723 REMARK 465 ILE C 724 REMARK 465 TYR C 725 REMARK 465 THR C 726 REMARK 465 LYS C 727 REMARK 465 LEU C 728 REMARK 465 TYR C 729 REMARK 465 CYS C 730 REMARK 465 ASN C 731 REMARK 465 LEU C 732 REMARK 465 GLU C 733 REMARK 465 LYS C 734 REMARK 465 GLU C 735 REMARK 465 ASP C 736 REMARK 465 LEU C 737 REMARK 465 SER C 738 REMARK 465 GLU C 739 REMARK 465 ASN C 740 REMARK 465 SER C 741 REMARK 465 GLN C 742 REMARK 465 SER C 743 REMARK 465 SER C 744 REMARK 465 MET C 745 REMARK 465 ILE C 746 REMARK 465 LYS C 747 REMARK 465 HIS C 748 REMARK 465 VAL C 749 REMARK 465 ALA C 750 REMARK 465 TRP C 751 REMARK 465 LEU C 752 REMARK 465 ILE C 753 REMARK 465 PHE C 754 REMARK 465 THR C 755 REMARK 465 ASN C 756 REMARK 465 CYS C 757 REMARK 465 ILE C 758 REMARK 465 PHE C 759 REMARK 465 PHE C 760 REMARK 465 CYS C 761 REMARK 465 PRO C 762 REMARK 465 VAL C 763 REMARK 465 ALA C 764 REMARK 465 PHE C 765 REMARK 465 PHE C 766 REMARK 465 SER C 767 REMARK 465 PHE C 768 REMARK 465 ALA C 769 REMARK 465 PRO C 770 REMARK 465 LEU C 771 REMARK 465 ILE C 772 REMARK 465 THR C 773 REMARK 465 ALA C 774 REMARK 465 ILE C 775 REMARK 465 SER C 776 REMARK 465 ILE C 777 REMARK 465 SER C 778 REMARK 465 PRO C 779 REMARK 465 GLU C 780 REMARK 465 ILE C 781 REMARK 465 MET C 782 REMARK 465 LYS C 783 REMARK 465 SER C 784 REMARK 465 VAL C 785 REMARK 465 THR C 786 REMARK 465 LEU C 787 REMARK 465 ILE C 788 REMARK 465 PHE C 789 REMARK 465 PHE C 790 REMARK 465 PRO C 791 REMARK 465 LEU C 792 REMARK 465 PRO C 793 REMARK 465 ALA C 794 REMARK 465 CYS C 795 REMARK 465 LEU C 796 REMARK 465 ASN C 797 REMARK 465 PRO C 798 REMARK 465 VAL C 799 REMARK 465 LEU C 800 REMARK 465 TYR C 801 REMARK 465 VAL C 802 REMARK 465 PHE C 803 REMARK 465 PHE C 804 REMARK 465 ASN C 805 REMARK 465 PRO C 806 REMARK 465 LYS C 807 REMARK 465 PHE C 808 REMARK 465 LYS C 809 REMARK 465 GLU C 810 REMARK 465 ASP C 811 REMARK 465 TRP C 812 REMARK 465 LYS C 813 REMARK 465 LEU C 814 REMARK 465 LEU C 815 REMARK 465 LYS C 816 REMARK 465 ARG C 817 REMARK 465 ARG C 818 REMARK 465 VAL C 819 REMARK 465 THR C 820 REMARK 465 LYS C 821 REMARK 465 LYS C 822 REMARK 465 SER C 823 REMARK 465 GLY C 824 REMARK 465 SER C 825 REMARK 465 VAL C 826 REMARK 465 SER C 827 REMARK 465 VAL C 828 REMARK 465 SER C 829 REMARK 465 ILE C 830 REMARK 465 SER C 831 REMARK 465 SER C 832 REMARK 465 GLN C 833 REMARK 465 GLY C 834 REMARK 465 GLY C 835 REMARK 465 CYS C 836 REMARK 465 LEU C 837 REMARK 465 GLU C 838 REMARK 465 GLN C 839 REMARK 465 ASP C 840 REMARK 465 PHE C 841 REMARK 465 TYR C 842 REMARK 465 TYR C 843 REMARK 465 ASP C 844 REMARK 465 CYS C 845 REMARK 465 GLY C 846 REMARK 465 MET C 847 REMARK 465 TYR C 848 REMARK 465 SER C 849 REMARK 465 HIS C 850 REMARK 465 LEU C 851 REMARK 465 GLN C 852 REMARK 465 GLY C 853 REMARK 465 ASN C 854 REMARK 465 LEU C 855 REMARK 465 THR C 856 REMARK 465 VAL C 857 REMARK 465 CYS C 858 REMARK 465 ASP C 859 REMARK 465 CYS C 860 REMARK 465 CYS C 861 REMARK 465 GLU C 862 REMARK 465 SER C 863 REMARK 465 PHE C 864 REMARK 465 LEU C 865 REMARK 465 LEU C 866 REMARK 465 THR C 867 REMARK 465 LYS C 868 REMARK 465 PRO C 869 REMARK 465 VAL C 870 REMARK 465 SER C 871 REMARK 465 CYS C 872 REMARK 465 LYS C 873 REMARK 465 HIS C 874 REMARK 465 LEU C 875 REMARK 465 ILE C 876 REMARK 465 LYS C 877 REMARK 465 SER C 878 REMARK 465 HIS C 879 REMARK 465 SER C 880 REMARK 465 CYS C 881 REMARK 465 PRO C 882 REMARK 465 ALA C 883 REMARK 465 LEU C 884 REMARK 465 ALA C 885 REMARK 465 VAL C 886 REMARK 465 ALA C 887 REMARK 465 SER C 888 REMARK 465 CYS C 889 REMARK 465 GLN C 890 REMARK 465 ARG C 891 REMARK 465 PRO C 892 REMARK 465 GLU C 893 REMARK 465 GLY C 894 REMARK 465 TYR C 895 REMARK 465 TRP C 896 REMARK 465 SER C 897 REMARK 465 ASP C 898 REMARK 465 CYS C 899 REMARK 465 GLY C 900 REMARK 465 THR C 901 REMARK 465 GLN C 902 REMARK 465 SER C 903 REMARK 465 ALA C 904 REMARK 465 HIS C 905 REMARK 465 SER C 906 REMARK 465 ASP C 907 REMARK 465 TYR C 908 REMARK 465 ALA C 909 REMARK 465 ASP C 910 REMARK 465 GLU C 911 REMARK 465 GLU C 912 REMARK 465 ASP C 913 REMARK 465 SER C 914 REMARK 465 PHE C 915 REMARK 465 VAL C 916 REMARK 465 SER C 917 REMARK 465 ASP C 918 REMARK 465 SER C 919 REMARK 465 SER C 920 REMARK 465 ASP C 921 REMARK 465 GLN C 922 REMARK 465 VAL C 923 REMARK 465 GLN C 924 REMARK 465 ALA C 925 REMARK 465 CYS C 926 REMARK 465 GLY C 927 REMARK 465 ARG C 928 REMARK 465 ALA C 929 REMARK 465 CYS C 930 REMARK 465 PHE C 931 REMARK 465 TYR C 932 REMARK 465 GLN C 933 REMARK 465 SER C 934 REMARK 465 ARG C 935 REMARK 465 GLY C 936 REMARK 465 PHE C 937 REMARK 465 PRO C 938 REMARK 465 LEU C 939 REMARK 465 VAL C 940 REMARK 465 ARG C 941 REMARK 465 TYR C 942 REMARK 465 ALA C 943 REMARK 465 TYR C 944 REMARK 465 ASN C 945 REMARK 465 LEU C 946 REMARK 465 PRO C 947 REMARK 465 ARG C 948 REMARK 465 VAL C 949 REMARK 465 LYS C 950 REMARK 465 ASP C 951 REMARK 465 ALA C 952 REMARK 465 ALA C 953 REMARK 465 ALA C 954 REMARK 465 ASP C 955 REMARK 465 TYR C 956 REMARK 465 LYS C 957 REMARK 465 ASP C 958 REMARK 465 ASP C 959 REMARK 465 ASP C 960 REMARK 465 ASP C 961 REMARK 465 LYS C 962 REMARK 465 MET E -13 REMARK 465 LEU E -12 REMARK 465 LEU E -11 REMARK 465 VAL E -10 REMARK 465 ASN E -9 REMARK 465 GLN E -8 REMARK 465 SER E -7 REMARK 465 HIS E -6 REMARK 465 GLN E -5 REMARK 465 GLY E -4 REMARK 465 PHE E -3 REMARK 465 ASN E -2 REMARK 465 LYS E -1 REMARK 465 GLU E 0 REMARK 465 HIS E 1 REMARK 465 THR E 2 REMARK 465 SER E 3 REMARK 465 LYS E 4 REMARK 465 MET E 5 REMARK 465 VAL E 6 REMARK 465 SER E 7 REMARK 465 ALA E 8 REMARK 465 ILE E 9 REMARK 465 VAL E 10 REMARK 465 LEU E 11 REMARK 465 TYR E 12 REMARK 465 VAL E 13 REMARK 465 LEU E 14 REMARK 465 LEU E 15 REMARK 465 ALA E 16 REMARK 465 ALA E 17 REMARK 465 ALA E 18 REMARK 465 ALA E 19 REMARK 465 HIS E 20 REMARK 465 SER E 21 REMARK 465 ALA E 22 REMARK 465 PHE E 23 REMARK 465 ALA E 24 REMARK 465 LYS E 25 REMARK 465 THR E 26 REMARK 465 ASP E 27 REMARK 465 SER E 28 REMARK 465 SER E 29 REMARK 465 PHE E 30 REMARK 465 ILE E 31 REMARK 465 MET E 32 REMARK 465 ASP E 33 REMARK 465 GLY E 112 REMARK 465 GLY E 134 REMARK 465 GLY E 135 REMARK 465 SER E 136 REMARK 465 GLY E 137 REMARK 465 GLY E 138 REMARK 465 SER E 139 REMARK 465 GLY E 140 REMARK 465 GLY E 141 REMARK 465 LEU E 142 REMARK 465 GLU E 143 REMARK 465 VAL E 144 REMARK 465 LEU E 145 REMARK 465 PHE E 146 REMARK 465 GLN E 147 REMARK 465 GLY E 148 REMARK 465 PRO E 149 REMARK 465 GLY E 150 REMARK 465 GLY E 151 REMARK 465 SER E 152 REMARK 465 GLY E 153 REMARK 465 GLY E 154 REMARK 465 SER E 155 REMARK 465 GLY E 156 REMARK 465 GLY E 157 REMARK 465 LYS E 158 REMARK 465 SER E 159 REMARK 465 CYS E 160 REMARK 465 ASP E 161 REMARK 465 LYS E 162 REMARK 465 THR E 163 REMARK 465 HIS E 164 REMARK 465 THR E 165 REMARK 465 CYS E 166 REMARK 465 PRO E 167 REMARK 465 PRO E 168 REMARK 465 CYS E 169 REMARK 465 PRO E 170 REMARK 465 ALA E 171 REMARK 465 PRO E 172 REMARK 465 GLU E 173 REMARK 465 LEU E 174 REMARK 465 LEU E 175 REMARK 465 GLY E 176 REMARK 465 GLY E 177 REMARK 465 PRO E 178 REMARK 465 SER E 179 REMARK 465 VAL E 180 REMARK 465 PHE E 181 REMARK 465 LEU E 182 REMARK 465 PHE E 183 REMARK 465 PRO E 184 REMARK 465 PRO E 185 REMARK 465 LYS E 186 REMARK 465 PRO E 187 REMARK 465 LYS E 188 REMARK 465 ASP E 189 REMARK 465 THR E 190 REMARK 465 LEU E 191 REMARK 465 MET E 192 REMARK 465 ILE E 193 REMARK 465 SER E 194 REMARK 465 ARG E 195 REMARK 465 THR E 196 REMARK 465 PRO E 197 REMARK 465 GLU E 198 REMARK 465 VAL E 199 REMARK 465 THR E 200 REMARK 465 CYS E 201 REMARK 465 VAL E 202 REMARK 465 VAL E 203 REMARK 465 VAL E 204 REMARK 465 ASP E 205 REMARK 465 VAL E 206 REMARK 465 SER E 207 REMARK 465 HIS E 208 REMARK 465 GLU E 209 REMARK 465 ASP E 210 REMARK 465 PRO E 211 REMARK 465 GLU E 212 REMARK 465 VAL E 213 REMARK 465 LYS E 214 REMARK 465 PHE E 215 REMARK 465 ASN E 216 REMARK 465 TRP E 217 REMARK 465 TYR E 218 REMARK 465 VAL E 219 REMARK 465 ASP E 220 REMARK 465 GLY E 221 REMARK 465 VAL E 222 REMARK 465 GLU E 223 REMARK 465 VAL E 224 REMARK 465 HIS E 225 REMARK 465 ASN E 226 REMARK 465 ALA E 227 REMARK 465 LYS E 228 REMARK 465 THR E 229 REMARK 465 LYS E 230 REMARK 465 PRO E 231 REMARK 465 ARG E 232 REMARK 465 GLU E 233 REMARK 465 GLU E 234 REMARK 465 GLN E 235 REMARK 465 TYR E 236 REMARK 465 ASN E 237 REMARK 465 SER E 238 REMARK 465 THR E 239 REMARK 465 TYR E 240 REMARK 465 ARG E 241 REMARK 465 VAL E 242 REMARK 465 VAL E 243 REMARK 465 SER E 244 REMARK 465 VAL E 245 REMARK 465 LEU E 246 REMARK 465 THR E 247 REMARK 465 VAL E 248 REMARK 465 LEU E 249 REMARK 465 HIS E 250 REMARK 465 GLN E 251 REMARK 465 ASP E 252 REMARK 465 TRP E 253 REMARK 465 LEU E 254 REMARK 465 ASN E 255 REMARK 465 GLY E 256 REMARK 465 LYS E 257 REMARK 465 GLU E 258 REMARK 465 TYR E 259 REMARK 465 LYS E 260 REMARK 465 CYS E 261 REMARK 465 LYS E 262 REMARK 465 VAL E 263 REMARK 465 SER E 264 REMARK 465 ASN E 265 REMARK 465 LYS E 266 REMARK 465 ALA E 267 REMARK 465 LEU E 268 REMARK 465 PRO E 269 REMARK 465 ALA E 270 REMARK 465 PRO E 271 REMARK 465 ILE E 272 REMARK 465 GLU E 273 REMARK 465 LYS E 274 REMARK 465 THR E 275 REMARK 465 ILE E 276 REMARK 465 SER E 277 REMARK 465 LYS E 278 REMARK 465 ALA E 279 REMARK 465 LYS E 280 REMARK 465 GLY E 281 REMARK 465 GLN E 282 REMARK 465 PRO E 283 REMARK 465 ARG E 284 REMARK 465 GLU E 285 REMARK 465 PRO E 286 REMARK 465 GLN E 287 REMARK 465 VAL E 288 REMARK 465 TYR E 289 REMARK 465 THR E 290 REMARK 465 LEU E 291 REMARK 465 PRO E 292 REMARK 465 PRO E 293 REMARK 465 SER E 294 REMARK 465 ARG E 295 REMARK 465 ASP E 296 REMARK 465 GLU E 297 REMARK 465 LEU E 298 REMARK 465 THR E 299 REMARK 465 LYS E 300 REMARK 465 ASN E 301 REMARK 465 GLN E 302 REMARK 465 VAL E 303 REMARK 465 SER E 304 REMARK 465 LEU E 305 REMARK 465 THR E 306 REMARK 465 CYS E 307 REMARK 465 LEU E 308 REMARK 465 VAL E 309 REMARK 465 LYS E 310 REMARK 465 GLY E 311 REMARK 465 PHE E 312 REMARK 465 TYR E 313 REMARK 465 PRO E 314 REMARK 465 SER E 315 REMARK 465 ASP E 316 REMARK 465 ILE E 317 REMARK 465 ALA E 318 REMARK 465 VAL E 319 REMARK 465 GLU E 320 REMARK 465 TRP E 321 REMARK 465 GLU E 322 REMARK 465 SER E 323 REMARK 465 ASN E 324 REMARK 465 GLY E 325 REMARK 465 GLN E 326 REMARK 465 PRO E 327 REMARK 465 GLU E 328 REMARK 465 ASN E 329 REMARK 465 ASN E 330 REMARK 465 TYR E 331 REMARK 465 LYS E 332 REMARK 465 ALA E 333 REMARK 465 THR E 334 REMARK 465 PRO E 335 REMARK 465 PRO E 336 REMARK 465 VAL E 337 REMARK 465 LEU E 338 REMARK 465 ASP E 339 REMARK 465 SER E 340 REMARK 465 ASP E 341 REMARK 465 GLY E 342 REMARK 465 SER E 343 REMARK 465 PHE E 344 REMARK 465 PHE E 345 REMARK 465 LEU E 346 REMARK 465 TYR E 347 REMARK 465 SER E 348 REMARK 465 LYS E 349 REMARK 465 LEU E 350 REMARK 465 THR E 351 REMARK 465 VAL E 352 REMARK 465 ASP E 353 REMARK 465 LYS E 354 REMARK 465 SER E 355 REMARK 465 ARG E 356 REMARK 465 TRP E 357 REMARK 465 GLN E 358 REMARK 465 GLN E 359 REMARK 465 GLY E 360 REMARK 465 ASN E 361 REMARK 465 VAL E 362 REMARK 465 PHE E 363 REMARK 465 SER E 364 REMARK 465 CYS E 365 REMARK 465 SER E 366 REMARK 465 VAL E 367 REMARK 465 MET E 368 REMARK 465 HIS E 369 REMARK 465 GLU E 370 REMARK 465 ALA E 371 REMARK 465 LEU E 372 REMARK 465 HIS E 373 REMARK 465 ASN E 374 REMARK 465 HIS E 375 REMARK 465 TYR E 376 REMARK 465 THR E 377 REMARK 465 GLN E 378 REMARK 465 LYS E 379 REMARK 465 SER E 380 REMARK 465 LEU E 381 REMARK 465 SER E 382 REMARK 465 LEU E 383 REMARK 465 SER E 384 REMARK 465 PRO E 385 REMARK 465 GLY E 386 REMARK 465 LYS E 387 REMARK 465 ASP E 388 REMARK 465 TYR E 389 REMARK 465 LYS E 390 REMARK 465 ASP E 391 REMARK 465 ASP E 392 REMARK 465 ASP E 393 REMARK 465 ASP E 394 REMARK 465 LYS E 395 REMARK 465 MET F -13 REMARK 465 LEU F -12 REMARK 465 LEU F -11 REMARK 465 VAL F -10 REMARK 465 ASN F -9 REMARK 465 GLN F -8 REMARK 465 SER F -7 REMARK 465 HIS F -6 REMARK 465 GLN F -5 REMARK 465 GLY F -4 REMARK 465 PHE F -3 REMARK 465 ASN F -2 REMARK 465 LYS F -1 REMARK 465 GLU F 0 REMARK 465 HIS F 1 REMARK 465 THR F 2 REMARK 465 SER F 3 REMARK 465 LYS F 4 REMARK 465 MET F 5 REMARK 465 VAL F 6 REMARK 465 SER F 7 REMARK 465 ALA F 8 REMARK 465 ILE F 9 REMARK 465 VAL F 10 REMARK 465 LEU F 11 REMARK 465 TYR F 12 REMARK 465 VAL F 13 REMARK 465 LEU F 14 REMARK 465 LEU F 15 REMARK 465 ALA F 16 REMARK 465 ALA F 17 REMARK 465 ALA F 18 REMARK 465 ALA F 19 REMARK 465 HIS F 20 REMARK 465 SER F 21 REMARK 465 ALA F 22 REMARK 465 PHE F 23 REMARK 465 ALA F 24 REMARK 465 LYS F 25 REMARK 465 THR F 26 REMARK 465 ASP F 27 REMARK 465 SER F 28 REMARK 465 SER F 29 REMARK 465 PHE F 30 REMARK 465 ILE F 31 REMARK 465 MET F 32 REMARK 465 ASP F 33 REMARK 465 SER F 34 REMARK 465 GLY F 134 REMARK 465 GLY F 135 REMARK 465 SER F 136 REMARK 465 GLY F 137 REMARK 465 GLY F 138 REMARK 465 SER F 139 REMARK 465 GLY F 140 REMARK 465 GLY F 141 REMARK 465 LEU F 142 REMARK 465 GLU F 143 REMARK 465 VAL F 144 REMARK 465 LEU F 145 REMARK 465 PHE F 146 REMARK 465 GLN F 147 REMARK 465 GLY F 148 REMARK 465 PRO F 149 REMARK 465 GLY F 150 REMARK 465 GLY F 151 REMARK 465 SER F 152 REMARK 465 GLY F 153 REMARK 465 GLY F 154 REMARK 465 SER F 155 REMARK 465 GLY F 156 REMARK 465 GLY F 157 REMARK 465 LYS F 158 REMARK 465 SER F 159 REMARK 465 CYS F 160 REMARK 465 ASP F 161 REMARK 465 LYS F 162 REMARK 465 THR F 163 REMARK 465 HIS F 164 REMARK 465 THR F 165 REMARK 465 CYS F 166 REMARK 465 PRO F 167 REMARK 465 PRO F 168 REMARK 465 CYS F 169 REMARK 465 PRO F 170 REMARK 465 ALA F 171 REMARK 465 PRO F 172 REMARK 465 GLU F 173 REMARK 465 LEU F 174 REMARK 465 LEU F 175 REMARK 465 GLY F 176 REMARK 465 GLY F 177 REMARK 465 PRO F 178 REMARK 465 SER F 179 REMARK 465 VAL F 180 REMARK 465 PHE F 181 REMARK 465 LEU F 182 REMARK 465 PHE F 183 REMARK 465 PRO F 184 REMARK 465 PRO F 185 REMARK 465 LYS F 186 REMARK 465 PRO F 187 REMARK 465 LYS F 188 REMARK 465 ASP F 189 REMARK 465 THR F 190 REMARK 465 LEU F 191 REMARK 465 MET F 192 REMARK 465 ILE F 193 REMARK 465 SER F 194 REMARK 465 ARG F 195 REMARK 465 THR F 196 REMARK 465 PRO F 197 REMARK 465 GLU F 198 REMARK 465 VAL F 199 REMARK 465 THR F 200 REMARK 465 CYS F 201 REMARK 465 VAL F 202 REMARK 465 VAL F 203 REMARK 465 VAL F 204 REMARK 465 ASP F 205 REMARK 465 VAL F 206 REMARK 465 SER F 207 REMARK 465 HIS F 208 REMARK 465 GLU F 209 REMARK 465 ASP F 210 REMARK 465 PRO F 211 REMARK 465 GLU F 212 REMARK 465 VAL F 213 REMARK 465 LYS F 214 REMARK 465 PHE F 215 REMARK 465 ASN F 216 REMARK 465 TRP F 217 REMARK 465 TYR F 218 REMARK 465 VAL F 219 REMARK 465 ASP F 220 REMARK 465 GLY F 221 REMARK 465 VAL F 222 REMARK 465 GLU F 223 REMARK 465 VAL F 224 REMARK 465 HIS F 225 REMARK 465 ASN F 226 REMARK 465 ALA F 227 REMARK 465 LYS F 228 REMARK 465 THR F 229 REMARK 465 LYS F 230 REMARK 465 PRO F 231 REMARK 465 ARG F 232 REMARK 465 GLU F 233 REMARK 465 GLU F 234 REMARK 465 GLN F 235 REMARK 465 TYR F 236 REMARK 465 ASN F 237 REMARK 465 SER F 238 REMARK 465 THR F 239 REMARK 465 TYR F 240 REMARK 465 ARG F 241 REMARK 465 VAL F 242 REMARK 465 VAL F 243 REMARK 465 SER F 244 REMARK 465 VAL F 245 REMARK 465 LEU F 246 REMARK 465 THR F 247 REMARK 465 VAL F 248 REMARK 465 LEU F 249 REMARK 465 HIS F 250 REMARK 465 GLN F 251 REMARK 465 ASP F 252 REMARK 465 TRP F 253 REMARK 465 LEU F 254 REMARK 465 ASN F 255 REMARK 465 GLY F 256 REMARK 465 LYS F 257 REMARK 465 GLU F 258 REMARK 465 TYR F 259 REMARK 465 LYS F 260 REMARK 465 CYS F 261 REMARK 465 LYS F 262 REMARK 465 VAL F 263 REMARK 465 SER F 264 REMARK 465 ASN F 265 REMARK 465 LYS F 266 REMARK 465 ALA F 267 REMARK 465 LEU F 268 REMARK 465 PRO F 269 REMARK 465 ALA F 270 REMARK 465 PRO F 271 REMARK 465 ILE F 272 REMARK 465 GLU F 273 REMARK 465 LYS F 274 REMARK 465 THR F 275 REMARK 465 ILE F 276 REMARK 465 SER F 277 REMARK 465 LYS F 278 REMARK 465 ALA F 279 REMARK 465 LYS F 280 REMARK 465 GLY F 281 REMARK 465 GLN F 282 REMARK 465 PRO F 283 REMARK 465 ARG F 284 REMARK 465 GLU F 285 REMARK 465 PRO F 286 REMARK 465 GLN F 287 REMARK 465 VAL F 288 REMARK 465 TYR F 289 REMARK 465 THR F 290 REMARK 465 LEU F 291 REMARK 465 PRO F 292 REMARK 465 PRO F 293 REMARK 465 SER F 294 REMARK 465 ARG F 295 REMARK 465 ASP F 296 REMARK 465 GLU F 297 REMARK 465 LEU F 298 REMARK 465 THR F 299 REMARK 465 LYS F 300 REMARK 465 ASN F 301 REMARK 465 GLN F 302 REMARK 465 VAL F 303 REMARK 465 SER F 304 REMARK 465 LEU F 305 REMARK 465 THR F 306 REMARK 465 CYS F 307 REMARK 465 LEU F 308 REMARK 465 VAL F 309 REMARK 465 LYS F 310 REMARK 465 GLY F 311 REMARK 465 PHE F 312 REMARK 465 TYR F 313 REMARK 465 PRO F 314 REMARK 465 SER F 315 REMARK 465 ASP F 316 REMARK 465 ILE F 317 REMARK 465 ALA F 318 REMARK 465 VAL F 319 REMARK 465 GLU F 320 REMARK 465 TRP F 321 REMARK 465 GLU F 322 REMARK 465 SER F 323 REMARK 465 ASN F 324 REMARK 465 GLY F 325 REMARK 465 GLN F 326 REMARK 465 PRO F 327 REMARK 465 GLU F 328 REMARK 465 ASN F 329 REMARK 465 ASN F 330 REMARK 465 TYR F 331 REMARK 465 LYS F 332 REMARK 465 ALA F 333 REMARK 465 THR F 334 REMARK 465 PRO F 335 REMARK 465 PRO F 336 REMARK 465 VAL F 337 REMARK 465 LEU F 338 REMARK 465 ASP F 339 REMARK 465 SER F 340 REMARK 465 ASP F 341 REMARK 465 GLY F 342 REMARK 465 SER F 343 REMARK 465 PHE F 344 REMARK 465 PHE F 345 REMARK 465 LEU F 346 REMARK 465 TYR F 347 REMARK 465 SER F 348 REMARK 465 LYS F 349 REMARK 465 LEU F 350 REMARK 465 THR F 351 REMARK 465 VAL F 352 REMARK 465 ASP F 353 REMARK 465 LYS F 354 REMARK 465 SER F 355 REMARK 465 ARG F 356 REMARK 465 TRP F 357 REMARK 465 GLN F 358 REMARK 465 GLN F 359 REMARK 465 GLY F 360 REMARK 465 ASN F 361 REMARK 465 VAL F 362 REMARK 465 PHE F 363 REMARK 465 SER F 364 REMARK 465 CYS F 365 REMARK 465 SER F 366 REMARK 465 VAL F 367 REMARK 465 MET F 368 REMARK 465 HIS F 369 REMARK 465 GLU F 370 REMARK 465 ALA F 371 REMARK 465 LEU F 372 REMARK 465 HIS F 373 REMARK 465 ASN F 374 REMARK 465 HIS F 375 REMARK 465 TYR F 376 REMARK 465 THR F 377 REMARK 465 GLN F 378 REMARK 465 LYS F 379 REMARK 465 SER F 380 REMARK 465 LEU F 381 REMARK 465 SER F 382 REMARK 465 LEU F 383 REMARK 465 SER F 384 REMARK 465 PRO F 385 REMARK 465 GLY F 386 REMARK 465 LYS F 387 REMARK 465 ASP F 388 REMARK 465 TYR F 389 REMARK 465 LYS F 390 REMARK 465 ASP F 391 REMARK 465 ASP F 392 REMARK 465 ASP F 393 REMARK 465 ASP F 394 REMARK 465 LYS F 395 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 MET C 66 38.22 -95.52 REMARK 500 LEU C 104 59.31 -90.41 REMARK 500 LEU C 160 33.36 -140.49 REMARK 500 LEU C 200 59.02 -93.13 REMARK 500 ASP C 265 135.62 -173.39 REMARK 500 LEU C 279 24.86 -141.22 REMARK 500 PRO C 283 49.05 -78.19 REMARK 500 LEU C 315 51.48 -92.76 REMARK 500 TYR C 352 -145.59 55.14 REMARK 500 ASN C 353 -174.74 63.50 REMARK 500 ILE C 389 -60.05 -107.61 REMARK 500 ARG C 392 -37.00 -130.08 REMARK 500 ARG C 398 16.55 57.78 REMARK 500 GLU C 424 66.67 -100.75 REMARK 500 ARG C 460 29.12 -140.45 REMARK 500 TYR C 466 -148.99 59.04 REMARK 500 GLN E 87 74.86 53.92 REMARK 500 CYS F 96 98.01 -69.77 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-64380 RELATED DB: EMDB REMARK 900 STRUCTURE OF THE COMPLEX OF LGR4_ECD WITH NORRIN DBREF 9UOK A -18 537 PDB 9UOK 9UOK -18 537 DBREF 9UOK C 24 951 UNP Q9BXB1 LGR4_HUMAN 24 951 DBREF 9UOK E 25 133 UNP Q00604 NDP_HUMAN 25 133 DBREF 9UOK E 158 387 UNP P0DOX5 IGG1_HUMAN 220 449 DBREF 9UOK F 25 133 UNP Q00604 NDP_HUMAN 25 133 DBREF 9UOK F 158 387 UNP P0DOX5 IGG1_HUMAN 220 449 SEQADV 9UOK MET C 9 UNP Q9BXB1 INITIATING METHIONINE SEQADV 9UOK LYS C 10 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK THR C 11 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ILE C 12 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ILE C 13 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ALA C 14 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK LEU C 15 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK SER C 16 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK TYR C 17 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ILE C 18 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK PHE C 19 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK CYS C 20 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK LEU C 21 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK VAL C 22 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK PHE C 23 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ALA C 952 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ALA C 953 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ALA C 954 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ASP C 955 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK TYR C 956 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK LYS C 957 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ASP C 958 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ASP C 959 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ASP C 960 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK ASP C 961 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK LYS C 962 UNP Q9BXB1 EXPRESSION TAG SEQADV 9UOK MET E -13 UNP Q00604 INITIATING METHIONINE SEQADV 9UOK LEU E -12 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU E -11 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL E -10 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ASN E -9 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLN E -8 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER E -7 UNP Q00604 EXPRESSION TAG SEQADV 9UOK HIS E -6 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLN E -5 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLY E -4 UNP Q00604 EXPRESSION TAG SEQADV 9UOK PHE E -3 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ASN E -2 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LYS E -1 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLU E 0 UNP Q00604 EXPRESSION TAG SEQADV 9UOK HIS E 1 UNP Q00604 EXPRESSION TAG SEQADV 9UOK THR E 2 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER E 3 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LYS E 4 UNP Q00604 EXPRESSION TAG SEQADV 9UOK MET E 5 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL E 6 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER E 7 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA E 8 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ILE E 9 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL E 10 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU E 11 UNP Q00604 EXPRESSION TAG SEQADV 9UOK TYR E 12 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL E 13 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU E 14 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU E 15 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA E 16 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA E 17 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA E 18 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA E 19 UNP Q00604 EXPRESSION TAG SEQADV 9UOK HIS E 20 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER E 21 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA E 22 UNP Q00604 EXPRESSION TAG SEQADV 9UOK PHE E 23 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA E 24 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLY E 134 UNP Q00604 LINKER SEQADV 9UOK GLY E 135 UNP Q00604 LINKER SEQADV 9UOK SER E 136 UNP Q00604 LINKER SEQADV 9UOK GLY E 137 UNP Q00604 LINKER SEQADV 9UOK GLY E 138 UNP Q00604 LINKER SEQADV 9UOK SER E 139 UNP Q00604 LINKER SEQADV 9UOK GLY E 140 UNP Q00604 LINKER SEQADV 9UOK GLY E 141 UNP Q00604 LINKER SEQADV 9UOK LEU E 142 UNP Q00604 LINKER SEQADV 9UOK GLU E 143 UNP Q00604 LINKER SEQADV 9UOK VAL E 144 UNP Q00604 LINKER SEQADV 9UOK LEU E 145 UNP Q00604 LINKER SEQADV 9UOK PHE E 146 UNP Q00604 LINKER SEQADV 9UOK GLN E 147 UNP Q00604 LINKER SEQADV 9UOK GLY E 148 UNP Q00604 LINKER SEQADV 9UOK PRO E 149 UNP Q00604 LINKER SEQADV 9UOK GLY E 150 UNP Q00604 LINKER SEQADV 9UOK GLY E 151 UNP Q00604 LINKER SEQADV 9UOK SER E 152 UNP Q00604 LINKER SEQADV 9UOK GLY E 153 UNP Q00604 LINKER SEQADV 9UOK GLY E 154 UNP Q00604 LINKER SEQADV 9UOK SER E 155 UNP Q00604 LINKER SEQADV 9UOK GLY E 156 UNP Q00604 LINKER SEQADV 9UOK GLY E 157 UNP Q00604 LINKER SEQADV 9UOK ALA E 333 UNP P0DOX5 THR 395 CONFLICT SEQADV 9UOK ASP E 388 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK TYR E 389 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK LYS E 390 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP E 391 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP E 392 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP E 393 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP E 394 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK LYS E 395 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK MET F -13 UNP Q00604 INITIATING METHIONINE SEQADV 9UOK LEU F -12 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU F -11 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL F -10 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ASN F -9 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLN F -8 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER F -7 UNP Q00604 EXPRESSION TAG SEQADV 9UOK HIS F -6 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLN F -5 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLY F -4 UNP Q00604 EXPRESSION TAG SEQADV 9UOK PHE F -3 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ASN F -2 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LYS F -1 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLU F 0 UNP Q00604 EXPRESSION TAG SEQADV 9UOK HIS F 1 UNP Q00604 EXPRESSION TAG SEQADV 9UOK THR F 2 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER F 3 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LYS F 4 UNP Q00604 EXPRESSION TAG SEQADV 9UOK MET F 5 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL F 6 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER F 7 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA F 8 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ILE F 9 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL F 10 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU F 11 UNP Q00604 EXPRESSION TAG SEQADV 9UOK TYR F 12 UNP Q00604 EXPRESSION TAG SEQADV 9UOK VAL F 13 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU F 14 UNP Q00604 EXPRESSION TAG SEQADV 9UOK LEU F 15 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA F 16 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA F 17 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA F 18 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA F 19 UNP Q00604 EXPRESSION TAG SEQADV 9UOK HIS F 20 UNP Q00604 EXPRESSION TAG SEQADV 9UOK SER F 21 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA F 22 UNP Q00604 EXPRESSION TAG SEQADV 9UOK PHE F 23 UNP Q00604 EXPRESSION TAG SEQADV 9UOK ALA F 24 UNP Q00604 EXPRESSION TAG SEQADV 9UOK GLY F 134 UNP Q00604 LINKER SEQADV 9UOK GLY F 135 UNP Q00604 LINKER SEQADV 9UOK SER F 136 UNP Q00604 LINKER SEQADV 9UOK GLY F 137 UNP Q00604 LINKER SEQADV 9UOK GLY F 138 UNP Q00604 LINKER SEQADV 9UOK SER F 139 UNP Q00604 LINKER SEQADV 9UOK GLY F 140 UNP Q00604 LINKER SEQADV 9UOK GLY F 141 UNP Q00604 LINKER SEQADV 9UOK LEU F 142 UNP Q00604 LINKER SEQADV 9UOK GLU F 143 UNP Q00604 LINKER SEQADV 9UOK VAL F 144 UNP Q00604 LINKER SEQADV 9UOK LEU F 145 UNP Q00604 LINKER SEQADV 9UOK PHE F 146 UNP Q00604 LINKER SEQADV 9UOK GLN F 147 UNP Q00604 LINKER SEQADV 9UOK GLY F 148 UNP Q00604 LINKER SEQADV 9UOK PRO F 149 UNP Q00604 LINKER SEQADV 9UOK GLY F 150 UNP Q00604 LINKER SEQADV 9UOK GLY F 151 UNP Q00604 LINKER SEQADV 9UOK SER F 152 UNP Q00604 LINKER SEQADV 9UOK GLY F 153 UNP Q00604 LINKER SEQADV 9UOK GLY F 154 UNP Q00604 LINKER SEQADV 9UOK SER F 155 UNP Q00604 LINKER SEQADV 9UOK GLY F 156 UNP Q00604 LINKER SEQADV 9UOK GLY F 157 UNP Q00604 LINKER SEQADV 9UOK ALA F 333 UNP P0DOX5 THR 395 CONFLICT SEQADV 9UOK ASP F 388 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK TYR F 389 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK LYS F 390 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP F 391 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP F 392 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP F 393 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK ASP F 394 UNP P0DOX5 EXPRESSION TAG SEQADV 9UOK LYS F 395 UNP P0DOX5 EXPRESSION TAG SEQRES 1 A 556 MET LYS LYS ILE TRP LEU ALA LEU ALA GLY LEU VAL LEU SEQRES 2 A 556 ALA PHE SER ALA SER ALA GLN VAL GLN LEU VAL GLU SER SEQRES 3 A 556 GLY GLY GLY LEU VAL GLN THR LYS THR THR THR SER VAL SEQRES 4 A 556 ILE ASP THR THR ASN ASP ALA GLN ASN LEU LEU THR GLN SEQRES 5 A 556 ALA GLN THR ILE VAL ASN THR LEU LYS ASP TYR CYS PRO SEQRES 6 A 556 ILE LEU ILE ALA LYS SER SER SER SER ASN GLY GLY THR SEQRES 7 A 556 ASN ASN ALA ASN THR PRO SER TRP GLN THR ALA GLY GLY SEQRES 8 A 556 GLY LYS ASN SER CYS ALA THR PHE GLY ALA GLU PHE SER SEQRES 9 A 556 ALA ALA SER ASP MET ILE ASN ASN ALA GLN LYS ILE VAL SEQRES 10 A 556 GLN GLU THR GLN GLN LEU SER ALA ASN GLN PRO LYS ASN SEQRES 11 A 556 ILE THR GLN PRO HIS ASN LEU ASN LEU ASN SER PRO SER SEQRES 12 A 556 SER LEU THR ALA LEU ALA GLN LYS MET LEU LYS ASN ALA SEQRES 13 A 556 GLN SER GLN ALA GLU ILE LEU LYS LEU ALA ASN GLN VAL SEQRES 14 A 556 GLU SER ASP PHE ASN LYS LEU SER SER GLY HIS LEU LYS SEQRES 15 A 556 ASP TYR ILE GLY LYS CYS ASP ALA SER ALA ILE SER SER SEQRES 16 A 556 ALA ASN MET THR MET GLN ASN GLN LYS ASN ASN TRP GLY SEQRES 17 A 556 ASN GLY CYS ALA GLY VAL GLU GLU THR GLN SER LEU LEU SEQRES 18 A 556 LYS THR SER ALA ALA ASP PHE ASN ASN GLN THR PRO GLN SEQRES 19 A 556 ILE ASN GLN ALA GLN ASN LEU ALA ASN THR LEU ILE GLN SEQRES 20 A 556 GLU LEU GLY ASN ASN PRO PHE ARG ALA SER GLY GLY GLY SEQRES 21 A 556 SER GLY GLY GLY GLY SER GLY LYS LEU SER ASP THR TYR SEQRES 22 A 556 GLU GLN LEU SER ARG LEU LEU THR ASN ASP ASN GLY THR SEQRES 23 A 556 ASN SER LYS THR SER ALA GLN ALA ILE ASN GLN ALA VAL SEQRES 24 A 556 ASN ASN LEU ASN GLU ARG ALA LYS THR LEU ALA GLY GLY SEQRES 25 A 556 THR THR ASN SER PRO ALA TYR GLN ALA THR LEU LEU ALA SEQRES 26 A 556 LEU ARG SER VAL LEU GLY LEU TRP ASN SER MET GLY TYR SEQRES 27 A 556 ALA VAL ILE CYS GLY GLY TYR THR LYS SER PRO GLY GLU SEQRES 28 A 556 ASN ASN GLN LYS ASP PHE HIS TYR THR ASP GLU ASN GLY SEQRES 29 A 556 ASN GLY THR THR ILE ASN CYS GLY GLY SER THR ASN SER SEQRES 30 A 556 ASN GLY THR HIS SER TYR ASN GLY THR ASN THR LEU LYS SEQRES 31 A 556 ALA ASP LYS ASN VAL SER LEU SER ILE GLU GLN TYR GLU SEQRES 32 A 556 LYS ILE HIS GLU ALA TYR GLN ILE LEU SER LYS ALA LEU SEQRES 33 A 556 LYS GLN ALA GLY LEU ALA PRO LEU ASN SER LYS GLY GLU SEQRES 34 A 556 LYS LEU GLU ALA HIS VAL THR THR SER LYS TYR GLY SER SEQRES 35 A 556 LEU ARG LEU SER CYS ALA ALA SER GLY TYR THR TYR SER SEQRES 36 A 556 PRO TYR CYS MET GLY TRP PHE ARG GLN ALA PRO GLY LYS SEQRES 37 A 556 ALA ARG GLU GLY VAL ALA THR VAL ASP LEU ASP GLY SER SEQRES 38 A 556 THR ILE TYR ALA ASP SER VAL LYS GLY ARG PHE THR ILE SEQRES 39 A 556 SER GLN ASP ASN ALA LYS ASN THR LEU TYR LEU GLN MET SEQRES 40 A 556 ASN SER LEU LYS PRO GLU ASP THR ALA MET TYR TYR CYS SEQRES 41 A 556 ALA SER ARG THR ARG ALA GLY VAL THR CYS GLY LEU ASN SEQRES 42 A 556 TRP ALA ILE PHE SER TYR TRP GLY GLN GLY THR GLN VAL SEQRES 43 A 556 THR VAL SER SER HIS HIS HIS HIS HIS HIS SEQRES 1 C 954 MET LYS THR ILE ILE ALA LEU SER TYR ILE PHE CYS LEU SEQRES 2 C 954 VAL PHE ALA ALA PRO PRO LEU CYS ALA ALA PRO CYS SER SEQRES 3 C 954 CYS ASP GLY ASP ARG ARG VAL ASP CYS SER GLY LYS GLY SEQRES 4 C 954 LEU THR ALA VAL PRO GLU GLY LEU SER ALA PHE THR GLN SEQRES 5 C 954 ALA LEU ASP ILE SER MET ASN ASN ILE THR GLN LEU PRO SEQRES 6 C 954 GLU ASP ALA PHE LYS ASN PHE PRO PHE LEU GLU GLU LEU SEQRES 7 C 954 GLN LEU ALA GLY ASN ASP LEU SER PHE ILE HIS PRO LYS SEQRES 8 C 954 ALA LEU SER GLY LEU LYS GLU LEU LYS VAL LEU THR LEU SEQRES 9 C 954 GLN ASN ASN GLN LEU LYS THR VAL PRO SER GLU ALA ILE SEQRES 10 C 954 ARG GLY LEU SER ALA LEU GLN SER LEU ARG LEU ASP ALA SEQRES 11 C 954 ASN HIS ILE THR SER VAL PRO GLU ASP SER PHE GLU GLY SEQRES 12 C 954 LEU VAL GLN LEU ARG HIS LEU TRP LEU ASP ASP ASN SER SEQRES 13 C 954 LEU THR GLU VAL PRO VAL HIS PRO LEU SER ASN LEU PRO SEQRES 14 C 954 THR LEU GLN ALA LEU THR LEU ALA LEU ASN LYS ILE SER SEQRES 15 C 954 SER ILE PRO ASP PHE ALA PHE THR ASN LEU SER SER LEU SEQRES 16 C 954 VAL VAL LEU HIS LEU HIS ASN ASN LYS ILE ARG SER LEU SEQRES 17 C 954 SER GLN HIS CYS PHE ASP GLY LEU ASP ASN LEU GLU THR SEQRES 18 C 954 LEU ASP LEU ASN TYR ASN ASN LEU GLY GLU PHE PRO GLN SEQRES 19 C 954 ALA ILE LYS ALA LEU PRO SER LEU LYS GLU LEU GLY PHE SEQRES 20 C 954 HIS SER ASN SER ILE SER VAL ILE PRO ASP GLY ALA PHE SEQRES 21 C 954 ASP GLY ASN PRO LEU LEU ARG THR ILE HIS LEU TYR ASP SEQRES 22 C 954 ASN PRO LEU SER PHE VAL GLY ASN SER ALA PHE HIS ASN SEQRES 23 C 954 LEU SER ASP LEU HIS SER LEU VAL ILE ARG GLY ALA SER SEQRES 24 C 954 MET VAL GLN GLN PHE PRO ASN LEU THR GLY THR VAL HIS SEQRES 25 C 954 LEU GLU SER LEU THR LEU THR GLY THR LYS ILE SER SER SEQRES 26 C 954 ILE PRO ASN ASN LEU CYS GLN GLU GLN LYS MET LEU ARG SEQRES 27 C 954 THR LEU ASP LEU SER TYR ASN ASN ILE ARG ASP LEU PRO SEQRES 28 C 954 SER PHE ASN GLY CYS HIS ALA LEU GLU GLU ILE SER LEU SEQRES 29 C 954 GLN ARG ASN GLN ILE TYR GLN ILE LYS GLU GLY THR PHE SEQRES 30 C 954 GLN GLY LEU ILE SER LEU ARG ILE LEU ASP LEU SER ARG SEQRES 31 C 954 ASN LEU ILE HIS GLU ILE HIS SER ARG ALA PHE ALA THR SEQRES 32 C 954 LEU GLY PRO ILE THR ASN LEU ASP VAL SER PHE ASN GLU SEQRES 33 C 954 LEU THR SER PHE PRO THR GLU GLY LEU ASN GLY LEU ASN SEQRES 34 C 954 GLN LEU LYS LEU VAL GLY ASN PHE LYS LEU LYS GLU ALA SEQRES 35 C 954 LEU ALA ALA LYS ASP PHE VAL ASN LEU ARG SER LEU SER SEQRES 36 C 954 VAL PRO TYR ALA TYR GLN CYS CYS ALA PHE TRP GLY CYS SEQRES 37 C 954 ASP SER TYR ALA ASN LEU ASN THR GLU ASP ASN SER LEU SEQRES 38 C 954 GLN ASP HIS SER VAL ALA GLN GLU LYS GLY THR ALA ASP SEQRES 39 C 954 ALA ALA ASN VAL THR SER THR LEU GLU ASN GLU GLU HIS SEQRES 40 C 954 SER GLN ILE ILE ILE HIS CYS THR PRO SER THR GLY ALA SEQRES 41 C 954 PHE LYS PRO CYS GLU TYR LEU LEU GLY SER TRP MET ILE SEQRES 42 C 954 ARG LEU THR VAL TRP PHE ILE PHE LEU VAL ALA LEU PHE SEQRES 43 C 954 PHE ASN LEU LEU VAL ILE LEU THR THR PHE ALA SER CYS SEQRES 44 C 954 THR SER LEU PRO SER SER LYS LEU PHE ILE GLY LEU ILE SEQRES 45 C 954 SER VAL SER ASN LEU PHE MET GLY ILE TYR THR GLY ILE SEQRES 46 C 954 LEU THR PHE LEU ASP ALA VAL SER TRP GLY ARG PHE ALA SEQRES 47 C 954 GLU PHE GLY ILE TRP TRP GLU THR GLY SER GLY CYS LYS SEQRES 48 C 954 VAL ALA GLY PHE LEU ALA VAL PHE SER SER GLU SER ALA SEQRES 49 C 954 ILE PHE LEU LEU MET LEU ALA THR VAL GLU ARG SER LEU SEQRES 50 C 954 SER ALA LYS ASP ILE MET LYS ASN GLY LYS SER ASN HIS SEQRES 51 C 954 LEU LYS GLN PHE ARG VAL ALA ALA LEU LEU ALA PHE LEU SEQRES 52 C 954 GLY ALA THR VAL ALA GLY CYS PHE PRO LEU PHE HIS ARG SEQRES 53 C 954 GLY GLU TYR SER ALA SER PRO LEU CYS LEU PRO PHE PRO SEQRES 54 C 954 THR GLY GLU THR PRO SER LEU GLY PHE THR VAL THR LEU SEQRES 55 C 954 VAL LEU LEU ASN SER LEU ALA PHE LEU LEU MET ALA VAL SEQRES 56 C 954 ILE TYR THR LYS LEU TYR CYS ASN LEU GLU LYS GLU ASP SEQRES 57 C 954 LEU SER GLU ASN SER GLN SER SER MET ILE LYS HIS VAL SEQRES 58 C 954 ALA TRP LEU ILE PHE THR ASN CYS ILE PHE PHE CYS PRO SEQRES 59 C 954 VAL ALA PHE PHE SER PHE ALA PRO LEU ILE THR ALA ILE SEQRES 60 C 954 SER ILE SER PRO GLU ILE MET LYS SER VAL THR LEU ILE SEQRES 61 C 954 PHE PHE PRO LEU PRO ALA CYS LEU ASN PRO VAL LEU TYR SEQRES 62 C 954 VAL PHE PHE ASN PRO LYS PHE LYS GLU ASP TRP LYS LEU SEQRES 63 C 954 LEU LYS ARG ARG VAL THR LYS LYS SER GLY SER VAL SER SEQRES 64 C 954 VAL SER ILE SER SER GLN GLY GLY CYS LEU GLU GLN ASP SEQRES 65 C 954 PHE TYR TYR ASP CYS GLY MET TYR SER HIS LEU GLN GLY SEQRES 66 C 954 ASN LEU THR VAL CYS ASP CYS CYS GLU SER PHE LEU LEU SEQRES 67 C 954 THR LYS PRO VAL SER CYS LYS HIS LEU ILE LYS SER HIS SEQRES 68 C 954 SER CYS PRO ALA LEU ALA VAL ALA SER CYS GLN ARG PRO SEQRES 69 C 954 GLU GLY TYR TRP SER ASP CYS GLY THR GLN SER ALA HIS SEQRES 70 C 954 SER ASP TYR ALA ASP GLU GLU ASP SER PHE VAL SER ASP SEQRES 71 C 954 SER SER ASP GLN VAL GLN ALA CYS GLY ARG ALA CYS PHE SEQRES 72 C 954 TYR GLN SER ARG GLY PHE PRO LEU VAL ARG TYR ALA TYR SEQRES 73 C 954 ASN LEU PRO ARG VAL LYS ASP ALA ALA ALA ASP TYR LYS SEQRES 74 C 954 ASP ASP ASP ASP LYS SEQRES 1 E 409 MET LEU LEU VAL ASN GLN SER HIS GLN GLY PHE ASN LYS SEQRES 2 E 409 GLU HIS THR SER LYS MET VAL SER ALA ILE VAL LEU TYR SEQRES 3 E 409 VAL LEU LEU ALA ALA ALA ALA HIS SER ALA PHE ALA LYS SEQRES 4 E 409 THR ASP SER SER PHE ILE MET ASP SER ASP PRO ARG ARG SEQRES 5 E 409 CYS MET ARG HIS HIS TYR VAL ASP SER ILE SER HIS PRO SEQRES 6 E 409 LEU TYR LYS CYS SER SER LYS MET VAL LEU LEU ALA ARG SEQRES 7 E 409 CYS GLU GLY HIS CYS SER GLN ALA SER ARG SER GLU PRO SEQRES 8 E 409 LEU VAL SER PHE SER THR VAL LEU LYS GLN PRO PHE ARG SEQRES 9 E 409 SER SER CYS HIS CYS CYS ARG PRO GLN THR SER LYS LEU SEQRES 10 E 409 LYS ALA LEU ARG LEU ARG CYS SER GLY GLY MET ARG LEU SEQRES 11 E 409 THR ALA THR TYR ARG TYR ILE LEU SER CYS HIS CYS GLU SEQRES 12 E 409 GLU CYS ASN SER GLY GLY SER GLY GLY SER GLY GLY LEU SEQRES 13 E 409 GLU VAL LEU PHE GLN GLY PRO GLY GLY SER GLY GLY SER SEQRES 14 E 409 GLY GLY LYS SER CYS ASP LYS THR HIS THR CYS PRO PRO SEQRES 15 E 409 CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL PHE SEQRES 16 E 409 LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SER SEQRES 17 E 409 ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SER SEQRES 18 E 409 HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL ASP SEQRES 19 E 409 GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG GLU SEQRES 20 E 409 GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL LEU SEQRES 21 E 409 THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU TYR SEQRES 22 E 409 LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO ILE SEQRES 23 E 409 GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG GLU SEQRES 24 E 409 PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU LEU SEQRES 25 E 409 THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS GLY SEQRES 26 E 409 PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER ASN SEQRES 27 E 409 GLY GLN PRO GLU ASN ASN TYR LYS ALA THR PRO PRO VAL SEQRES 28 E 409 LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS LEU SEQRES 29 E 409 THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL PHE SEQRES 30 E 409 SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS TYR SEQRES 31 E 409 THR GLN LYS SER LEU SER LEU SER PRO GLY LYS ASP TYR SEQRES 32 E 409 LYS ASP ASP ASP ASP LYS SEQRES 1 F 409 MET LEU LEU VAL ASN GLN SER HIS GLN GLY PHE ASN LYS SEQRES 2 F 409 GLU HIS THR SER LYS MET VAL SER ALA ILE VAL LEU TYR SEQRES 3 F 409 VAL LEU LEU ALA ALA ALA ALA HIS SER ALA PHE ALA LYS SEQRES 4 F 409 THR ASP SER SER PHE ILE MET ASP SER ASP PRO ARG ARG SEQRES 5 F 409 CYS MET ARG HIS HIS TYR VAL ASP SER ILE SER HIS PRO SEQRES 6 F 409 LEU TYR LYS CYS SER SER LYS MET VAL LEU LEU ALA ARG SEQRES 7 F 409 CYS GLU GLY HIS CYS SER GLN ALA SER ARG SER GLU PRO SEQRES 8 F 409 LEU VAL SER PHE SER THR VAL LEU LYS GLN PRO PHE ARG SEQRES 9 F 409 SER SER CYS HIS CYS CYS ARG PRO GLN THR SER LYS LEU SEQRES 10 F 409 LYS ALA LEU ARG LEU ARG CYS SER GLY GLY MET ARG LEU SEQRES 11 F 409 THR ALA THR TYR ARG TYR ILE LEU SER CYS HIS CYS GLU SEQRES 12 F 409 GLU CYS ASN SER GLY GLY SER GLY GLY SER GLY GLY LEU SEQRES 13 F 409 GLU VAL LEU PHE GLN GLY PRO GLY GLY SER GLY GLY SER SEQRES 14 F 409 GLY GLY LYS SER CYS ASP LYS THR HIS THR CYS PRO PRO SEQRES 15 F 409 CYS PRO ALA PRO GLU LEU LEU GLY GLY PRO SER VAL PHE SEQRES 16 F 409 LEU PHE PRO PRO LYS PRO LYS ASP THR LEU MET ILE SER SEQRES 17 F 409 ARG THR PRO GLU VAL THR CYS VAL VAL VAL ASP VAL SER SEQRES 18 F 409 HIS GLU ASP PRO GLU VAL LYS PHE ASN TRP TYR VAL ASP SEQRES 19 F 409 GLY VAL GLU VAL HIS ASN ALA LYS THR LYS PRO ARG GLU SEQRES 20 F 409 GLU GLN TYR ASN SER THR TYR ARG VAL VAL SER VAL LEU SEQRES 21 F 409 THR VAL LEU HIS GLN ASP TRP LEU ASN GLY LYS GLU TYR SEQRES 22 F 409 LYS CYS LYS VAL SER ASN LYS ALA LEU PRO ALA PRO ILE SEQRES 23 F 409 GLU LYS THR ILE SER LYS ALA LYS GLY GLN PRO ARG GLU SEQRES 24 F 409 PRO GLN VAL TYR THR LEU PRO PRO SER ARG ASP GLU LEU SEQRES 25 F 409 THR LYS ASN GLN VAL SER LEU THR CYS LEU VAL LYS GLY SEQRES 26 F 409 PHE TYR PRO SER ASP ILE ALA VAL GLU TRP GLU SER ASN SEQRES 27 F 409 GLY GLN PRO GLU ASN ASN TYR LYS ALA THR PRO PRO VAL SEQRES 28 F 409 LEU ASP SER ASP GLY SER PHE PHE LEU TYR SER LYS LEU SEQRES 29 F 409 THR VAL ASP LYS SER ARG TRP GLN GLN GLY ASN VAL PHE SEQRES 30 F 409 SER CYS SER VAL MET HIS GLU ALA LEU HIS ASN HIS TYR SEQRES 31 F 409 THR GLN LYS SER LEU SER LEU SER PRO GLY LYS ASP TYR SEQRES 32 F 409 LYS ASP ASP ASP ASP LYS HELIX 1 AA1 ASP A 467 LYS A 470 5 4 HELIX 2 AA2 LYS A 492 THR A 496 5 5 HELIX 3 AA3 PRO C 121 ARG C 126 1 6 HELIX 4 AA4 PRO C 169 ASN C 175 1 7 HELIX 5 AA5 PRO C 241 LEU C 247 5 7 HELIX 6 AA6 ASN C 337 GLN C 342 1 6 HELIX 7 AA7 HIS C 405 ALA C 410 5 6 HELIX 8 AA8 SER F 111 GLY F 113 5 3 SHEET 1 AA1 3 LEU A 424 LEU A 426 0 SHEET 2 AA1 3 LEU A 486 MET A 488 -1 O LEU A 486 N LEU A 426 SHEET 3 AA1 3 PHE A 473 ILE A 475 -1 N THR A 474 O GLN A 487 SHEET 1 AA2 5 THR A 463 TYR A 465 0 SHEET 2 AA2 5 ARG A 451 ASP A 458 -1 N THR A 456 O ILE A 464 SHEET 3 AA2 5 CYS A 439 GLN A 445 -1 N MET A 440 O VAL A 457 SHEET 4 AA2 5 ALA A 497 ARG A 504 -1 O ALA A 502 N GLY A 441 SHEET 5 AA2 5 TYR A 520 TRP A 521 -1 O TYR A 520 N SER A 503 SHEET 1 AA3 5 THR A 463 TYR A 465 0 SHEET 2 AA3 5 ARG A 451 ASP A 458 -1 N THR A 456 O ILE A 464 SHEET 3 AA3 5 CYS A 439 GLN A 445 -1 N MET A 440 O VAL A 457 SHEET 4 AA3 5 ALA A 497 ARG A 504 -1 O ALA A 502 N GLY A 441 SHEET 5 AA3 5 THR A 525 VAL A 527 -1 O VAL A 527 N ALA A 497 SHEET 1 AA411 ARG C 40 ASP C 42 0 SHEET 2 AA411 ALA C 61 ASP C 63 1 O ALA C 61 N VAL C 41 SHEET 3 AA411 GLU C 85 GLN C 87 1 O GLU C 85 N LEU C 62 SHEET 4 AA411 VAL C 109 THR C 111 1 O VAL C 109 N LEU C 86 SHEET 5 AA411 SER C 133 ARG C 135 1 O ARG C 135 N LEU C 110 SHEET 6 AA411 HIS C 157 TRP C 159 1 O TRP C 159 N LEU C 134 SHEET 7 AA411 ALA C 181 THR C 183 1 O ALA C 181 N LEU C 158 SHEET 8 AA411 VAL C 205 HIS C 207 1 O VAL C 205 N LEU C 182 SHEET 9 AA411 THR C 229 ASP C 231 1 O ASP C 231 N LEU C 206 SHEET 10 AA411 GLU C 252 GLY C 254 1 O GLU C 252 N LEU C 230 SHEET 11 AA411 THR C 276 HIS C 278 1 O THR C 276 N LEU C 253 SHEET 1 AA5 2 GLN C 71 LEU C 72 0 SHEET 2 AA5 2 PHE C 95 ILE C 96 1 O PHE C 95 N LEU C 72 SHEET 1 AA6 2 SER C 191 ILE C 192 0 SHEET 2 AA6 2 SER C 215 LEU C 216 1 O SER C 215 N ILE C 192 SHEET 1 AA7 2 VAL C 262 ILE C 263 0 SHEET 2 AA7 2 PHE C 286 VAL C 287 1 O PHE C 286 N ILE C 263 SHEET 1 AA8 8 SER C 300 ARG C 304 0 SHEET 2 AA8 8 SER C 323 THR C 327 1 O THR C 325 N ILE C 303 SHEET 3 AA8 8 THR C 347 ASP C 349 1 O ASP C 349 N LEU C 326 SHEET 4 AA8 8 GLU C 369 SER C 371 1 O SER C 371 N LEU C 348 SHEET 5 AA8 8 ILE C 393 ASP C 395 1 O ILE C 393 N ILE C 370 SHEET 6 AA8 8 ASN C 417 ASP C 419 1 O ASN C 417 N LEU C 394 SHEET 7 AA8 8 GLN C 438 LYS C 440 1 O LYS C 440 N LEU C 418 SHEET 8 AA8 8 SER C 461 SER C 463 1 O SER C 461 N LEU C 439 SHEET 1 AA9 4 MET E 40 ASP E 46 0 SHEET 2 AA9 4 VAL E 60 GLY E 67 -1 O LEU E 62 N TYR E 44 SHEET 3 AA9 4 SER F 73 PRO F 77 -1 O SER F 75 N CYS E 65 SHEET 4 AA9 4 PHE F 89 SER F 92 -1 O ARG F 90 N GLU F 76 SHEET 1 AB1 4 PHE E 89 SER E 92 0 SHEET 2 AB1 4 SER E 73 PRO E 77 -1 N ARG E 74 O SER E 92 SHEET 3 AB1 4 LYS F 58 GLY F 67 -1 O GLY F 67 N SER E 73 SHEET 4 AB1 4 MET F 40 ILE F 48 -1 N TYR F 44 O LEU F 62 SHEET 1 AB2 2 HIS E 94 ARG E 97 0 SHEET 2 AB2 2 HIS E 127 GLU E 130 -1 O GLU E 129 N CYS E 95 SHEET 1 AB3 3 SER E 101 ARG E 109 0 SHEET 2 AB3 3 ARG E 115 ILE E 123 -1 O TYR E 120 N LYS E 104 SHEET 3 AB3 3 VAL F 79 SER F 80 -1 O SER F 80 N THR E 119 SHEET 1 AB4 2 HIS F 94 ARG F 109 0 SHEET 2 AB4 2 ARG F 115 GLU F 130 -1 O TYR F 120 N LYS F 104 SSBOND 1 CYS A 428 CYS A 501 1555 1555 2.04 SSBOND 2 CYS C 33 CYS C 43 1555 1555 2.03 SSBOND 3 CYS C 339 CYS C 364 1555 1555 2.03 SSBOND 4 CYS E 39 CYS E 96 1555 1555 2.03 SSBOND 5 CYS E 55 CYS E 110 1555 1555 2.03 SSBOND 6 CYS E 65 CYS E 126 1555 1555 2.03 SSBOND 7 CYS E 69 CYS E 128 1555 1555 2.03 SSBOND 8 CYS E 93 CYS F 95 1555 1555 2.04 SSBOND 9 CYS E 95 CYS F 93 1555 1555 2.03 SSBOND 10 CYS E 131 CYS F 131 1555 1555 2.03 SSBOND 11 CYS F 39 CYS F 96 1555 1555 2.03 SSBOND 12 CYS F 55 CYS F 110 1555 1555 2.03 SSBOND 13 CYS F 65 CYS F 126 1555 1555 2.03 SSBOND 14 CYS F 69 CYS F 128 1555 1555 2.03 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000