HEADER STRUCTURAL PROTEIN 15-NOV-25 9XOU TITLE CRYOEM STRUCTURE OF LACY WITH TRIMBODY COMPND MOL_ID: 1; COMPND 2 MOLECULE: H3-PRAC-5350A,2-DEHYDRO-3-DEOXYPHOSPHOGLUCONATE ALDOLASE/4- COMPND 3 HYDROXY-2-OXOGLUTARATE ALDOLASE; COMPND 4 CHAIN: A, B, C; COMPND 5 ENGINEERED: YES; COMPND 6 MOL_ID: 2; COMPND 7 MOLECULE: LACY-NANOBODY-TAIL; COMPND 8 CHAIN: D, E, F; COMPND 9 ENGINEERED: YES; COMPND 10 MOL_ID: 3; COMPND 11 MOLECULE: LACTOSE PERMEASE; COMPND 12 CHAIN: G, H, I; COMPND 13 SYNONYM: LACTOSE-PROTON SYMPORT; COMPND 14 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT, THERMOTOGA MARITIMA SOURCE 3 (STRAIN ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8); SOURCE 4 ORGANISM_TAXID: 32630, 243274; SOURCE 5 STRAIN: ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8; SOURCE 6 GENE: TM_0066; SOURCE 7 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 8 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 9 MOL_ID: 2; SOURCE 10 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT; SOURCE 11 ORGANISM_TAXID: 32630; SOURCE 12 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 13 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 14 MOL_ID: 3; SOURCE 15 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI K-12; SOURCE 16 ORGANISM_TAXID: 83333; SOURCE 17 GENE: LACY, B0343, JW0334; SOURCE 18 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 19 EXPRESSION_SYSTEM_TAXID: 562 KEYWDS STRUCTURAL PROTEIN EXPDTA ELECTRON MICROSCOPY AUTHOR J.Y.SONG,W.WANG REVDAT 1 11-FEB-26 9XOU 0 JRNL AUTH J.Y.SONG,W.WANG JRNL TITL CRYOEM STRUCTURE OF LACY WITH TRIMBODY JRNL REF TO BE PUBLISHED JRNL REFN REMARK 2 REMARK 2 RESOLUTION. 2.50 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 SOFTWARE PACKAGES : CRYOSPARC, CRYOSPARC REMARK 3 RECONSTRUCTION SCHEMA : NULL REMARK 3 REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT REMARK 3 PDB ENTRY : NULL REMARK 3 REFINEMENT SPACE : NULL REMARK 3 REFINEMENT PROTOCOL : NULL REMARK 3 REFINEMENT TARGET : NULL REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL REMARK 3 REMARK 3 FITTING PROCEDURE : NULL REMARK 3 REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 2.500 REMARK 3 NUMBER OF PARTICLES : 371100 REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE REMARK 3 CORRECTION REMARK 3 REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL REMARK 3 REMARK 3 OTHER DETAILS: NULL REMARK 4 REMARK 4 9XOU COMPLIES WITH FORMAT V. 3.30, 13-JUL-11 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 19-NOV-25. REMARK 100 THE DEPOSITION ID IS D_1300065675. REMARK 245 REMARK 245 EXPERIMENTAL DETAILS REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE REMARK 245 SPECIMEN TYPE : NULL REMARK 245 REMARK 245 ELECTRON MICROSCOPE SAMPLE REMARK 245 SAMPLE TYPE : PARTICLE REMARK 245 PARTICLE TYPE : POINT REMARK 245 NAME OF SAMPLE : CRYOEM STRUCTURE OF LACY WITH REMARK 245 TRIMBODY REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL REMARK 245 SAMPLE SUPPORT DETAILS : NULL REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL REMARK 245 SAMPLE BUFFER : NULL REMARK 245 PH : 7.40 REMARK 245 SAMPLE DETAILS : NULL REMARK 245 REMARK 245 DATA ACQUISITION REMARK 245 DATE OF EXPERIMENT : NULL REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL REMARK 245 TEMPERATURE (KELVIN) : NULL REMARK 245 MICROSCOPE MODEL : TFS KRIOS REMARK 245 DETECTOR TYPE : FEI FALCON IV (4K X 4K) REMARK 245 MINIMUM DEFOCUS (NM) : 1000.00 REMARK 245 MAXIMUM DEFOCUS (NM) : 2500.00 REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL REMARK 245 NOMINAL CS : NULL REMARK 245 IMAGING MODE : BRIGHT FIELD REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6000.00 REMARK 245 ILLUMINATION MODE : FLOOD BEAM REMARK 245 NOMINAL MAGNIFICATION : NULL REMARK 245 CALIBRATED MAGNIFICATION : NULL REMARK 245 SOURCE : FIELD EMISSION GUN REMARK 245 ACCELERATION VOLTAGE (KV) : 300 REMARK 245 IMAGING DETAILS : NULL REMARK 247 REMARK 247 ELECTRON MICROSCOPY REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION REMARK 247 OF THE STRUCTURE FACTORS. REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 GLU A 321 REMARK 465 ALA A 322 REMARK 465 ALA A 323 REMARK 465 ALA A 324 REMARK 465 LEU A 325 REMARK 465 GLU A 326 REMARK 465 HIS A 327 REMARK 465 HIS A 328 REMARK 465 HIS A 329 REMARK 465 HIS A 330 REMARK 465 HIS A 331 REMARK 465 HIS A 332 REMARK 465 MET B 1 REMARK 465 THR B 320 REMARK 465 GLU B 321 REMARK 465 ALA B 322 REMARK 465 ALA B 323 REMARK 465 ALA B 324 REMARK 465 LEU B 325 REMARK 465 GLU B 326 REMARK 465 HIS B 327 REMARK 465 HIS B 328 REMARK 465 HIS B 329 REMARK 465 HIS B 330 REMARK 465 HIS B 331 REMARK 465 HIS B 332 REMARK 465 MET C 1 REMARK 465 GLU C 321 REMARK 465 ALA C 322 REMARK 465 ALA C 323 REMARK 465 ALA C 324 REMARK 465 LEU C 325 REMARK 465 GLU C 326 REMARK 465 HIS C 327 REMARK 465 HIS C 328 REMARK 465 HIS C 329 REMARK 465 HIS C 330 REMARK 465 HIS C 331 REMARK 465 HIS C 332 REMARK 465 MET D 1 REMARK 465 SER D 250 REMARK 465 HIS D 251 REMARK 465 PRO D 252 REMARK 465 GLN D 253 REMARK 465 PHE D 254 REMARK 465 GLU D 255 REMARK 465 LYS D 256 REMARK 465 MET E 1 REMARK 465 SER E 250 REMARK 465 HIS E 251 REMARK 465 PRO E 252 REMARK 465 GLN E 253 REMARK 465 PHE E 254 REMARK 465 GLU E 255 REMARK 465 LYS E 256 REMARK 465 MET F 1 REMARK 465 SER F 250 REMARK 465 HIS F 251 REMARK 465 PRO F 252 REMARK 465 GLN F 253 REMARK 465 PHE F 254 REMARK 465 GLU F 255 REMARK 465 LYS F 256 REMARK 465 ALA G 191 REMARK 465 PRO G 192 REMARK 465 SER G 193 REMARK 465 SER G 194 REMARK 465 ALA G 195 REMARK 465 THR G 196 REMARK 465 VAL G 197 REMARK 465 ALA G 198 REMARK 465 ASN G 199 REMARK 465 ALA G 200 REMARK 465 VAL G 201 REMARK 465 GLY G 202 REMARK 465 ALA G 203 REMARK 465 ASN G 204 REMARK 465 HIS G 205 REMARK 465 LEU G 406 REMARK 465 SER G 407 REMARK 465 LEU G 408 REMARK 465 LEU G 409 REMARK 465 ARG G 410 REMARK 465 ARG G 411 REMARK 465 GLN G 412 REMARK 465 VAL G 413 REMARK 465 ASN G 414 REMARK 465 GLU G 415 REMARK 465 VAL G 416 REMARK 465 ALA G 417 REMARK 465 TRP G 418 REMARK 465 SER G 419 REMARK 465 HIS G 420 REMARK 465 PRO G 421 REMARK 465 GLN G 422 REMARK 465 PHE G 423 REMARK 465 GLU G 424 REMARK 465 LYS G 425 REMARK 465 GLY G 426 REMARK 465 SER G 427 REMARK 465 HIS G 428 REMARK 465 HIS G 429 REMARK 465 HIS G 430 REMARK 465 HIS G 431 REMARK 465 HIS G 432 REMARK 465 HIS G 433 REMARK 465 HIS G 434 REMARK 465 HIS G 435 REMARK 465 HIS G 436 REMARK 465 HIS G 437 REMARK 465 ALA H 191 REMARK 465 PRO H 192 REMARK 465 SER H 193 REMARK 465 SER H 194 REMARK 465 ALA H 195 REMARK 465 THR H 196 REMARK 465 VAL H 197 REMARK 465 ALA H 198 REMARK 465 ASN H 199 REMARK 465 ALA H 200 REMARK 465 VAL H 201 REMARK 465 GLY H 202 REMARK 465 ALA H 203 REMARK 465 ASN H 204 REMARK 465 HIS H 205 REMARK 465 LEU H 406 REMARK 465 SER H 407 REMARK 465 LEU H 408 REMARK 465 LEU H 409 REMARK 465 ARG H 410 REMARK 465 ARG H 411 REMARK 465 GLN H 412 REMARK 465 VAL H 413 REMARK 465 ASN H 414 REMARK 465 GLU H 415 REMARK 465 VAL H 416 REMARK 465 ALA H 417 REMARK 465 TRP H 418 REMARK 465 SER H 419 REMARK 465 HIS H 420 REMARK 465 PRO H 421 REMARK 465 GLN H 422 REMARK 465 PHE H 423 REMARK 465 GLU H 424 REMARK 465 LYS H 425 REMARK 465 GLY H 426 REMARK 465 SER H 427 REMARK 465 HIS H 428 REMARK 465 HIS H 429 REMARK 465 HIS H 430 REMARK 465 HIS H 431 REMARK 465 HIS H 432 REMARK 465 HIS H 433 REMARK 465 HIS H 434 REMARK 465 HIS H 435 REMARK 465 HIS H 436 REMARK 465 HIS H 437 REMARK 465 ALA I 191 REMARK 465 PRO I 192 REMARK 465 SER I 193 REMARK 465 SER I 194 REMARK 465 ALA I 195 REMARK 465 THR I 196 REMARK 465 VAL I 197 REMARK 465 ALA I 198 REMARK 465 ASN I 199 REMARK 465 ALA I 200 REMARK 465 VAL I 201 REMARK 465 GLY I 202 REMARK 465 ALA I 203 REMARK 465 ASN I 204 REMARK 465 HIS I 205 REMARK 465 LEU I 406 REMARK 465 SER I 407 REMARK 465 LEU I 408 REMARK 465 LEU I 409 REMARK 465 ARG I 410 REMARK 465 ARG I 411 REMARK 465 GLN I 412 REMARK 465 VAL I 413 REMARK 465 ASN I 414 REMARK 465 GLU I 415 REMARK 465 VAL I 416 REMARK 465 ALA I 417 REMARK 465 TRP I 418 REMARK 465 SER I 419 REMARK 465 HIS I 420 REMARK 465 PRO I 421 REMARK 465 GLN I 422 REMARK 465 PHE I 423 REMARK 465 GLU I 424 REMARK 465 LYS I 425 REMARK 465 GLY I 426 REMARK 465 SER I 427 REMARK 465 HIS I 428 REMARK 465 HIS I 429 REMARK 465 HIS I 430 REMARK 465 HIS I 431 REMARK 465 HIS I 432 REMARK 465 HIS I 433 REMARK 465 HIS I 434 REMARK 465 HIS I 435 REMARK 465 HIS I 436 REMARK 465 HIS I 437 REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 ASN B 74 58.77 -96.06 REMARK 500 PRO B 265 38.53 -87.22 REMARK 500 ALA D 101 -41.85 -131.70 REMARK 500 TYR D 105 47.74 -83.33 REMARK 500 LEU D 146 -146.11 58.17 REMARK 500 ALA E 101 -41.86 -131.66 REMARK 500 TYR E 105 47.68 -83.32 REMARK 500 LEU E 146 -146.11 58.21 REMARK 500 ALA F 101 -41.85 -131.65 REMARK 500 TYR F 105 47.67 -83.30 REMARK 500 LEU F 146 -146.12 58.23 REMARK 500 ASP G 36 -62.15 -99.49 REMARK 500 ASN G 102 82.23 58.80 REMARK 500 ASN G 165 130.03 -35.00 REMARK 500 VAL G 232 -54.97 -124.27 REMARK 500 PHE G 345 31.18 -98.77 REMARK 500 ASP H 36 -62.20 -99.43 REMARK 500 ASN H 102 82.22 58.78 REMARK 500 ASN H 165 130.03 -35.03 REMARK 500 VAL H 232 -54.94 -124.23 REMARK 500 PHE H 345 31.23 -98.80 REMARK 500 ASN I 102 82.26 58.82 REMARK 500 ASN I 165 130.11 -35.07 REMARK 500 VAL I 232 -54.95 -124.31 REMARK 500 PHE I 345 31.15 -98.79 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: EMD-67088 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-67089 RELATED DB: EMDB REMARK 900 RELATED ID: EMD-67094 RELATED DB: EMDB REMARK 900 CRYOEM STRUCTURE OF LACY WITH TRIMBODY DBREF 9XOU A 1 117 PDB 9XOU 9XOU 1 117 DBREF 9XOU A 118 321 UNP Q9WXS1 Q9WXS1_THEMA 2 205 DBREF 9XOU B 1 117 PDB 9XOU 9XOU 1 117 DBREF 9XOU B 118 321 UNP Q9WXS1 Q9WXS1_THEMA 2 205 DBREF 9XOU C 1 117 PDB 9XOU 9XOU 1 117 DBREF 9XOU C 118 321 UNP Q9WXS1 Q9WXS1_THEMA 2 205 DBREF 9XOU D 1 256 PDB 9XOU 9XOU 1 256 DBREF 9XOU E 1 256 PDB 9XOU 9XOU 1 256 DBREF 9XOU F 1 256 PDB 9XOU 9XOU 1 256 DBREF 9XOU G 1 417 UNP P02920 LACY_ECOLI 1 417 DBREF 9XOU H 1 417 UNP P02920 LACY_ECOLI 1 417 DBREF 9XOU I 1 417 UNP P02920 LACY_ECOLI 1 417 SEQADV 9XOU ILE A 141 UNP Q9WXS1 LYS 25 CONFLICT SEQADV 9XOU VAL A 145 UNP Q9WXS1 LEU 29 CONFLICT SEQADV 9XOU ALA A 149 UNP Q9WXS1 GLU 33 CONFLICT SEQADV 9XOU ALA A 170 UNP Q9WXS1 GLU 54 CONFLICT SEQADV 9XOU VAL A 173 UNP Q9WXS1 PHE 57 CONFLICT SEQADV 9XOU ALA A 322 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ALA A 323 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ALA A 324 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU LEU A 325 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU GLU A 326 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS A 327 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS A 328 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS A 329 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS A 330 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS A 331 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS A 332 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ILE B 141 UNP Q9WXS1 LYS 25 CONFLICT SEQADV 9XOU VAL B 145 UNP Q9WXS1 LEU 29 CONFLICT SEQADV 9XOU ALA B 149 UNP Q9WXS1 GLU 33 CONFLICT SEQADV 9XOU ALA B 170 UNP Q9WXS1 GLU 54 CONFLICT SEQADV 9XOU VAL B 173 UNP Q9WXS1 PHE 57 CONFLICT SEQADV 9XOU ALA B 322 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ALA B 323 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ALA B 324 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU LEU B 325 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU GLU B 326 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS B 327 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS B 328 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS B 329 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS B 330 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS B 331 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS B 332 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ILE C 141 UNP Q9WXS1 LYS 25 CONFLICT SEQADV 9XOU VAL C 145 UNP Q9WXS1 LEU 29 CONFLICT SEQADV 9XOU ALA C 149 UNP Q9WXS1 GLU 33 CONFLICT SEQADV 9XOU ALA C 170 UNP Q9WXS1 GLU 54 CONFLICT SEQADV 9XOU VAL C 173 UNP Q9WXS1 PHE 57 CONFLICT SEQADV 9XOU ALA C 322 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ALA C 323 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU ALA C 324 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU LEU C 325 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU GLU C 326 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS C 327 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS C 328 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS C 329 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS C 330 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS C 331 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU HIS C 332 UNP Q9WXS1 EXPRESSION TAG SEQADV 9XOU TRP G 46 UNP P02920 GLY 46 CONFLICT SEQADV 9XOU SER G 117 UNP P02920 CYS 117 CONFLICT SEQADV 9XOU ALA G 148 UNP P02920 CYS 148 CONFLICT SEQADV 9XOU VAL G 154 UNP P02920 CYS 154 CONFLICT SEQADV 9XOU MET G 176 UNP P02920 CYS 176 CONFLICT SEQADV 9XOU SER G 234 UNP P02920 CYS 234 CONFLICT SEQADV 9XOU TRP G 262 UNP P02920 GLY 262 CONFLICT SEQADV 9XOU SER G 333 UNP P02920 CYS 333 CONFLICT SEQADV 9XOU ALA G 353 UNP P02920 CYS 353 CONFLICT SEQADV 9XOU ALA G 355 UNP P02920 CYS 355 CONFLICT SEQADV 9XOU TRP G 418 UNP P02920 EXPRESSION TAG SEQADV 9XOU SER G 419 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 420 UNP P02920 EXPRESSION TAG SEQADV 9XOU PRO G 421 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLN G 422 UNP P02920 EXPRESSION TAG SEQADV 9XOU PHE G 423 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLU G 424 UNP P02920 EXPRESSION TAG SEQADV 9XOU LYS G 425 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLY G 426 UNP P02920 EXPRESSION TAG SEQADV 9XOU SER G 427 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 428 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 429 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 430 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 431 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 432 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 433 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 434 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 435 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 436 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS G 437 UNP P02920 EXPRESSION TAG SEQADV 9XOU TRP H 46 UNP P02920 GLY 46 CONFLICT SEQADV 9XOU SER H 117 UNP P02920 CYS 117 CONFLICT SEQADV 9XOU ALA H 148 UNP P02920 CYS 148 CONFLICT SEQADV 9XOU VAL H 154 UNP P02920 CYS 154 CONFLICT SEQADV 9XOU MET H 176 UNP P02920 CYS 176 CONFLICT SEQADV 9XOU SER H 234 UNP P02920 CYS 234 CONFLICT SEQADV 9XOU TRP H 262 UNP P02920 GLY 262 CONFLICT SEQADV 9XOU SER H 333 UNP P02920 CYS 333 CONFLICT SEQADV 9XOU ALA H 353 UNP P02920 CYS 353 CONFLICT SEQADV 9XOU ALA H 355 UNP P02920 CYS 355 CONFLICT SEQADV 9XOU TRP H 418 UNP P02920 EXPRESSION TAG SEQADV 9XOU SER H 419 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 420 UNP P02920 EXPRESSION TAG SEQADV 9XOU PRO H 421 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLN H 422 UNP P02920 EXPRESSION TAG SEQADV 9XOU PHE H 423 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLU H 424 UNP P02920 EXPRESSION TAG SEQADV 9XOU LYS H 425 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLY H 426 UNP P02920 EXPRESSION TAG SEQADV 9XOU SER H 427 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 428 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 429 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 430 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 431 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 432 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 433 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 434 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 435 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 436 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS H 437 UNP P02920 EXPRESSION TAG SEQADV 9XOU TRP I 46 UNP P02920 GLY 46 CONFLICT SEQADV 9XOU SER I 117 UNP P02920 CYS 117 CONFLICT SEQADV 9XOU ALA I 148 UNP P02920 CYS 148 CONFLICT SEQADV 9XOU VAL I 154 UNP P02920 CYS 154 CONFLICT SEQADV 9XOU MET I 176 UNP P02920 CYS 176 CONFLICT SEQADV 9XOU SER I 234 UNP P02920 CYS 234 CONFLICT SEQADV 9XOU TRP I 262 UNP P02920 GLY 262 CONFLICT SEQADV 9XOU SER I 333 UNP P02920 CYS 333 CONFLICT SEQADV 9XOU ALA I 353 UNP P02920 CYS 353 CONFLICT SEQADV 9XOU ALA I 355 UNP P02920 CYS 355 CONFLICT SEQADV 9XOU TRP I 418 UNP P02920 EXPRESSION TAG SEQADV 9XOU SER I 419 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 420 UNP P02920 EXPRESSION TAG SEQADV 9XOU PRO I 421 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLN I 422 UNP P02920 EXPRESSION TAG SEQADV 9XOU PHE I 423 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLU I 424 UNP P02920 EXPRESSION TAG SEQADV 9XOU LYS I 425 UNP P02920 EXPRESSION TAG SEQADV 9XOU GLY I 426 UNP P02920 EXPRESSION TAG SEQADV 9XOU SER I 427 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 428 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 429 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 430 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 431 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 432 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 433 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 434 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 435 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 436 UNP P02920 EXPRESSION TAG SEQADV 9XOU HIS I 437 UNP P02920 EXPRESSION TAG SEQRES 1 A 332 MET LYS GLU ILE ALA LYS ILE VAL ALA GLU LEU LEU ARG SEQRES 2 A 332 GLY ILE ALA ARG ILE ILE ASP ASP ILE LYS GLY ARG ASP SEQRES 3 A 332 ARG GLU GLU GLU VAL GLU ILE LEU ALA LYS ALA VAL GLU SEQRES 4 A 332 LYS THR GLY LYS PRO GLU ASP VAL ARG LEU ALA LEU GLU SEQRES 5 A 332 ALA ALA GLU ARG GLY VAL THR LEU ASP GLN ALA LYS ALA SEQRES 6 A 332 ILE ALA GLN ILE LEU SER MET PRO ASN LEU THR ASP GLU SEQRES 7 A 332 GLN LYS ARG GLY PHE VAL GLN SER LEU LEU ASP ASP PRO SEQRES 8 A 332 SER VAL SER LYS GLU ILE LEU ALA GLU ALA LYS LYS LEU SEQRES 9 A 332 ASN GLU HIS GLN ALA ALA LYS ALA GLU GLU ALA ALA ARG SEQRES 10 A 332 LYS MET GLU GLU LEU PHE LYS LYS HIS LYS ILE VAL ALA SEQRES 11 A 332 VAL LEU ARG ALA ASN SER VAL GLU GLU ALA ILE GLU LYS SEQRES 12 A 332 ALA VAL ALA VAL PHE ALA GLY GLY VAL HIS LEU ILE GLU SEQRES 13 A 332 ILE THR PHE THR VAL PRO ASP ALA ASP THR VAL ILE LYS SEQRES 14 A 332 ALA LEU SER VAL LEU LYS GLU LYS GLY ALA ILE ILE GLY SEQRES 15 A 332 ALA GLY THR VAL THR SER VAL GLU GLN CYS ARG LYS ALA SEQRES 16 A 332 VAL GLU SER GLY ALA GLU PHE ILE VAL SER PRO HIS LEU SEQRES 17 A 332 ASP GLU GLU ILE SER GLN PHE CYS LYS GLU LYS GLY VAL SEQRES 18 A 332 PHE TYR MET PRO GLY VAL MET THR PRO THR GLU LEU VAL SEQRES 19 A 332 LYS ALA MET LYS LEU GLY HIS THR ILE LEU LYS LEU PHE SEQRES 20 A 332 PRO GLY GLU VAL VAL GLY PRO GLN PHE VAL LYS ALA MET SEQRES 21 A 332 LYS GLY PRO PHE PRO ASN VAL LYS PHE VAL PRO THR GLY SEQRES 22 A 332 GLY VAL ASN LEU ASP ASN VAL CYS GLU TRP PHE LYS ALA SEQRES 23 A 332 GLY VAL LEU ALA VAL GLY VAL GLY SER ALA LEU VAL LYS SEQRES 24 A 332 GLY THR PRO ASP GLU VAL ARG GLU LYS ALA LYS ALA PHE SEQRES 25 A 332 VAL GLU LYS ILE ARG GLY CYS THR GLU ALA ALA ALA LEU SEQRES 26 A 332 GLU HIS HIS HIS HIS HIS HIS SEQRES 1 B 332 MET LYS GLU ILE ALA LYS ILE VAL ALA GLU LEU LEU ARG SEQRES 2 B 332 GLY ILE ALA ARG ILE ILE ASP ASP ILE LYS GLY ARG ASP SEQRES 3 B 332 ARG GLU GLU GLU VAL GLU ILE LEU ALA LYS ALA VAL GLU SEQRES 4 B 332 LYS THR GLY LYS PRO GLU ASP VAL ARG LEU ALA LEU GLU SEQRES 5 B 332 ALA ALA GLU ARG GLY VAL THR LEU ASP GLN ALA LYS ALA SEQRES 6 B 332 ILE ALA GLN ILE LEU SER MET PRO ASN LEU THR ASP GLU SEQRES 7 B 332 GLN LYS ARG GLY PHE VAL GLN SER LEU LEU ASP ASP PRO SEQRES 8 B 332 SER VAL SER LYS GLU ILE LEU ALA GLU ALA LYS LYS LEU SEQRES 9 B 332 ASN GLU HIS GLN ALA ALA LYS ALA GLU GLU ALA ALA ARG SEQRES 10 B 332 LYS MET GLU GLU LEU PHE LYS LYS HIS LYS ILE VAL ALA SEQRES 11 B 332 VAL LEU ARG ALA ASN SER VAL GLU GLU ALA ILE GLU LYS SEQRES 12 B 332 ALA VAL ALA VAL PHE ALA GLY GLY VAL HIS LEU ILE GLU SEQRES 13 B 332 ILE THR PHE THR VAL PRO ASP ALA ASP THR VAL ILE LYS SEQRES 14 B 332 ALA LEU SER VAL LEU LYS GLU LYS GLY ALA ILE ILE GLY SEQRES 15 B 332 ALA GLY THR VAL THR SER VAL GLU GLN CYS ARG LYS ALA SEQRES 16 B 332 VAL GLU SER GLY ALA GLU PHE ILE VAL SER PRO HIS LEU SEQRES 17 B 332 ASP GLU GLU ILE SER GLN PHE CYS LYS GLU LYS GLY VAL SEQRES 18 B 332 PHE TYR MET PRO GLY VAL MET THR PRO THR GLU LEU VAL SEQRES 19 B 332 LYS ALA MET LYS LEU GLY HIS THR ILE LEU LYS LEU PHE SEQRES 20 B 332 PRO GLY GLU VAL VAL GLY PRO GLN PHE VAL LYS ALA MET SEQRES 21 B 332 LYS GLY PRO PHE PRO ASN VAL LYS PHE VAL PRO THR GLY SEQRES 22 B 332 GLY VAL ASN LEU ASP ASN VAL CYS GLU TRP PHE LYS ALA SEQRES 23 B 332 GLY VAL LEU ALA VAL GLY VAL GLY SER ALA LEU VAL LYS SEQRES 24 B 332 GLY THR PRO ASP GLU VAL ARG GLU LYS ALA LYS ALA PHE SEQRES 25 B 332 VAL GLU LYS ILE ARG GLY CYS THR GLU ALA ALA ALA LEU SEQRES 26 B 332 GLU HIS HIS HIS HIS HIS HIS SEQRES 1 C 332 MET LYS GLU ILE ALA LYS ILE VAL ALA GLU LEU LEU ARG SEQRES 2 C 332 GLY ILE ALA ARG ILE ILE ASP ASP ILE LYS GLY ARG ASP SEQRES 3 C 332 ARG GLU GLU GLU VAL GLU ILE LEU ALA LYS ALA VAL GLU SEQRES 4 C 332 LYS THR GLY LYS PRO GLU ASP VAL ARG LEU ALA LEU GLU SEQRES 5 C 332 ALA ALA GLU ARG GLY VAL THR LEU ASP GLN ALA LYS ALA SEQRES 6 C 332 ILE ALA GLN ILE LEU SER MET PRO ASN LEU THR ASP GLU SEQRES 7 C 332 GLN LYS ARG GLY PHE VAL GLN SER LEU LEU ASP ASP PRO SEQRES 8 C 332 SER VAL SER LYS GLU ILE LEU ALA GLU ALA LYS LYS LEU SEQRES 9 C 332 ASN GLU HIS GLN ALA ALA LYS ALA GLU GLU ALA ALA ARG SEQRES 10 C 332 LYS MET GLU GLU LEU PHE LYS LYS HIS LYS ILE VAL ALA SEQRES 11 C 332 VAL LEU ARG ALA ASN SER VAL GLU GLU ALA ILE GLU LYS SEQRES 12 C 332 ALA VAL ALA VAL PHE ALA GLY GLY VAL HIS LEU ILE GLU SEQRES 13 C 332 ILE THR PHE THR VAL PRO ASP ALA ASP THR VAL ILE LYS SEQRES 14 C 332 ALA LEU SER VAL LEU LYS GLU LYS GLY ALA ILE ILE GLY SEQRES 15 C 332 ALA GLY THR VAL THR SER VAL GLU GLN CYS ARG LYS ALA SEQRES 16 C 332 VAL GLU SER GLY ALA GLU PHE ILE VAL SER PRO HIS LEU SEQRES 17 C 332 ASP GLU GLU ILE SER GLN PHE CYS LYS GLU LYS GLY VAL SEQRES 18 C 332 PHE TYR MET PRO GLY VAL MET THR PRO THR GLU LEU VAL SEQRES 19 C 332 LYS ALA MET LYS LEU GLY HIS THR ILE LEU LYS LEU PHE SEQRES 20 C 332 PRO GLY GLU VAL VAL GLY PRO GLN PHE VAL LYS ALA MET SEQRES 21 C 332 LYS GLY PRO PHE PRO ASN VAL LYS PHE VAL PRO THR GLY SEQRES 22 C 332 GLY VAL ASN LEU ASP ASN VAL CYS GLU TRP PHE LYS ALA SEQRES 23 C 332 GLY VAL LEU ALA VAL GLY VAL GLY SER ALA LEU VAL LYS SEQRES 24 C 332 GLY THR PRO ASP GLU VAL ARG GLU LYS ALA LYS ALA PHE SEQRES 25 C 332 VAL GLU LYS ILE ARG GLY CYS THR GLU ALA ALA ALA LEU SEQRES 26 C 332 GLU HIS HIS HIS HIS HIS HIS SEQRES 1 D 256 MET GLN VAL GLN LEU VAL GLU SER GLY GLY ARG LEU VAL SEQRES 2 D 256 GLN ALA GLY ASP SER LEU ARG LEU SER CYS ALA ALA SER SEQRES 3 D 256 GLY ARG THR PHE THR THR TYR LEU MET GLY TRP PHE ARG SEQRES 4 D 256 GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA ALA ILE SEQRES 5 D 256 ARG TRP SER GLY GLY SER THR TYR TYR ALA ASP SER VAL SEQRES 6 D 256 LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SEQRES 7 D 256 THR VAL TYR LEU GLN MET ASN SER LEU LYS LEU GLU ASP SEQRES 8 D 256 THR ALA VAL TYR TYR CYS ALA ALA ALA ALA ARG PRO SER SEQRES 9 D 256 TYR SER GLY ASP TYR GLY TYR THR GLU ALA LEU ARG TYR SEQRES 10 D 256 ASP TYR TRP GLY GLN GLY THR LEU VAL ALA VAL VAL LYS SEQRES 11 D 256 THR VAL GLU ASP ALA PHE LEU ALA LEU LEU ALA LEU GLU SEQRES 12 D 256 GLN HIS LEU GLY VAL GLN PRO ALA ASP LEU ALA ALA LEU SEQRES 13 D 256 ALA GLU LYS LEU ASN LEU SER GLN LEU LEU GLU LEU GLY SEQRES 14 D 256 GLU LEU LEU LYS ALA ALA GLY HIS PRO LEU ALA PRO GLN SEQRES 15 D 256 VAL GLU ALA LEU LEU LYS GLU LYS LEU LYS ALA ALA SER SEQRES 16 D 256 ALA ALA GLU ALA ALA GLY VAL ILE PHE GLN ALA LEU VAL SEQRES 17 D 256 LYS ASP GLU GLU LEU GLY LYS LYS ILE LEU GLU TRP ALA SEQRES 18 D 256 LYS GLU PHE GLY THR GLU GLU ALA LYS LYS ALA ILE GLU SEQRES 19 D 256 ILE ALA GLU LYS ALA TYR GLU LEU TYR LYS LYS TYR GLY SEQRES 20 D 256 SER TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 E 256 MET GLN VAL GLN LEU VAL GLU SER GLY GLY ARG LEU VAL SEQRES 2 E 256 GLN ALA GLY ASP SER LEU ARG LEU SER CYS ALA ALA SER SEQRES 3 E 256 GLY ARG THR PHE THR THR TYR LEU MET GLY TRP PHE ARG SEQRES 4 E 256 GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA ALA ILE SEQRES 5 E 256 ARG TRP SER GLY GLY SER THR TYR TYR ALA ASP SER VAL SEQRES 6 E 256 LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SEQRES 7 E 256 THR VAL TYR LEU GLN MET ASN SER LEU LYS LEU GLU ASP SEQRES 8 E 256 THR ALA VAL TYR TYR CYS ALA ALA ALA ALA ARG PRO SER SEQRES 9 E 256 TYR SER GLY ASP TYR GLY TYR THR GLU ALA LEU ARG TYR SEQRES 10 E 256 ASP TYR TRP GLY GLN GLY THR LEU VAL ALA VAL VAL LYS SEQRES 11 E 256 THR VAL GLU ASP ALA PHE LEU ALA LEU LEU ALA LEU GLU SEQRES 12 E 256 GLN HIS LEU GLY VAL GLN PRO ALA ASP LEU ALA ALA LEU SEQRES 13 E 256 ALA GLU LYS LEU ASN LEU SER GLN LEU LEU GLU LEU GLY SEQRES 14 E 256 GLU LEU LEU LYS ALA ALA GLY HIS PRO LEU ALA PRO GLN SEQRES 15 E 256 VAL GLU ALA LEU LEU LYS GLU LYS LEU LYS ALA ALA SER SEQRES 16 E 256 ALA ALA GLU ALA ALA GLY VAL ILE PHE GLN ALA LEU VAL SEQRES 17 E 256 LYS ASP GLU GLU LEU GLY LYS LYS ILE LEU GLU TRP ALA SEQRES 18 E 256 LYS GLU PHE GLY THR GLU GLU ALA LYS LYS ALA ILE GLU SEQRES 19 E 256 ILE ALA GLU LYS ALA TYR GLU LEU TYR LYS LYS TYR GLY SEQRES 20 E 256 SER TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 F 256 MET GLN VAL GLN LEU VAL GLU SER GLY GLY ARG LEU VAL SEQRES 2 F 256 GLN ALA GLY ASP SER LEU ARG LEU SER CYS ALA ALA SER SEQRES 3 F 256 GLY ARG THR PHE THR THR TYR LEU MET GLY TRP PHE ARG SEQRES 4 F 256 GLN ALA PRO GLY LYS GLU ARG GLU PHE VAL ALA ALA ILE SEQRES 5 F 256 ARG TRP SER GLY GLY SER THR TYR TYR ALA ASP SER VAL SEQRES 6 F 256 LYS GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SEQRES 7 F 256 THR VAL TYR LEU GLN MET ASN SER LEU LYS LEU GLU ASP SEQRES 8 F 256 THR ALA VAL TYR TYR CYS ALA ALA ALA ALA ARG PRO SER SEQRES 9 F 256 TYR SER GLY ASP TYR GLY TYR THR GLU ALA LEU ARG TYR SEQRES 10 F 256 ASP TYR TRP GLY GLN GLY THR LEU VAL ALA VAL VAL LYS SEQRES 11 F 256 THR VAL GLU ASP ALA PHE LEU ALA LEU LEU ALA LEU GLU SEQRES 12 F 256 GLN HIS LEU GLY VAL GLN PRO ALA ASP LEU ALA ALA LEU SEQRES 13 F 256 ALA GLU LYS LEU ASN LEU SER GLN LEU LEU GLU LEU GLY SEQRES 14 F 256 GLU LEU LEU LYS ALA ALA GLY HIS PRO LEU ALA PRO GLN SEQRES 15 F 256 VAL GLU ALA LEU LEU LYS GLU LYS LEU LYS ALA ALA SER SEQRES 16 F 256 ALA ALA GLU ALA ALA GLY VAL ILE PHE GLN ALA LEU VAL SEQRES 17 F 256 LYS ASP GLU GLU LEU GLY LYS LYS ILE LEU GLU TRP ALA SEQRES 18 F 256 LYS GLU PHE GLY THR GLU GLU ALA LYS LYS ALA ILE GLU SEQRES 19 F 256 ILE ALA GLU LYS ALA TYR GLU LEU TYR LYS LYS TYR GLY SEQRES 20 F 256 SER TRP SER HIS PRO GLN PHE GLU LYS SEQRES 1 G 437 MET TYR TYR LEU LYS ASN THR ASN PHE TRP MET PHE GLY SEQRES 2 G 437 LEU PHE PHE PHE PHE TYR PHE PHE ILE MET GLY ALA TYR SEQRES 3 G 437 PHE PRO PHE PHE PRO ILE TRP LEU HIS ASP ILE ASN HIS SEQRES 4 G 437 ILE SER LYS SER ASP THR TRP ILE ILE PHE ALA ALA ILE SEQRES 5 G 437 SER LEU PHE SER LEU LEU PHE GLN PRO LEU PHE GLY LEU SEQRES 6 G 437 LEU SER ASP LYS LEU GLY LEU ARG LYS TYR LEU LEU TRP SEQRES 7 G 437 ILE ILE THR GLY MET LEU VAL MET PHE ALA PRO PHE PHE SEQRES 8 G 437 ILE PHE ILE PHE GLY PRO LEU LEU GLN TYR ASN ILE LEU SEQRES 9 G 437 VAL GLY SER ILE VAL GLY GLY ILE TYR LEU GLY PHE SER SEQRES 10 G 437 PHE ASN ALA GLY ALA PRO ALA VAL GLU ALA PHE ILE GLU SEQRES 11 G 437 LYS VAL SER ARG ARG SER ASN PHE GLU PHE GLY ARG ALA SEQRES 12 G 437 ARG MET PHE GLY ALA VAL GLY TRP ALA LEU VAL ALA SER SEQRES 13 G 437 ILE VAL GLY ILE MET PHE THR ILE ASN ASN GLN PHE VAL SEQRES 14 G 437 PHE TRP LEU GLY SER GLY MET ALA LEU ILE LEU ALA VAL SEQRES 15 G 437 LEU LEU PHE PHE ALA LYS THR ASP ALA PRO SER SER ALA SEQRES 16 G 437 THR VAL ALA ASN ALA VAL GLY ALA ASN HIS SER ALA PHE SEQRES 17 G 437 SER LEU LYS LEU ALA LEU GLU LEU PHE ARG GLN PRO LYS SEQRES 18 G 437 LEU TRP PHE LEU SER LEU TYR VAL ILE GLY VAL SER SER SEQRES 19 G 437 THR TYR ASP VAL PHE ASP GLN GLN PHE ALA ASN PHE PHE SEQRES 20 G 437 THR SER PHE PHE ALA THR GLY GLU GLN GLY THR ARG VAL SEQRES 21 G 437 PHE TRP TYR VAL THR THR MET GLY GLU LEU LEU ASN ALA SEQRES 22 G 437 SER ILE MET PHE PHE ALA PRO LEU ILE ILE ASN ARG ILE SEQRES 23 G 437 GLY GLY LYS ASN ALA LEU LEU LEU ALA GLY THR ILE MET SEQRES 24 G 437 SER VAL ARG ILE ILE GLY SER SER PHE ALA THR SER ALA SEQRES 25 G 437 LEU GLU VAL VAL ILE LEU LYS THR LEU HIS MET PHE GLU SEQRES 26 G 437 VAL PRO PHE LEU LEU VAL GLY SER PHE LYS TYR ILE THR SEQRES 27 G 437 SER GLN PHE GLU VAL ARG PHE SER ALA THR ILE TYR LEU SEQRES 28 G 437 VAL ALA PHE ALA PHE PHE LYS GLN LEU ALA MET ILE PHE SEQRES 29 G 437 MET SER VAL LEU ALA GLY ASN MET TYR GLU SER ILE GLY SEQRES 30 G 437 PHE GLN GLY ALA TYR LEU VAL LEU GLY LEU VAL ALA LEU SEQRES 31 G 437 GLY PHE THR LEU ILE SER VAL PHE THR LEU SER GLY PRO SEQRES 32 G 437 GLY PRO LEU SER LEU LEU ARG ARG GLN VAL ASN GLU VAL SEQRES 33 G 437 ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SER HIS HIS SEQRES 34 G 437 HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 H 437 MET TYR TYR LEU LYS ASN THR ASN PHE TRP MET PHE GLY SEQRES 2 H 437 LEU PHE PHE PHE PHE TYR PHE PHE ILE MET GLY ALA TYR SEQRES 3 H 437 PHE PRO PHE PHE PRO ILE TRP LEU HIS ASP ILE ASN HIS SEQRES 4 H 437 ILE SER LYS SER ASP THR TRP ILE ILE PHE ALA ALA ILE SEQRES 5 H 437 SER LEU PHE SER LEU LEU PHE GLN PRO LEU PHE GLY LEU SEQRES 6 H 437 LEU SER ASP LYS LEU GLY LEU ARG LYS TYR LEU LEU TRP SEQRES 7 H 437 ILE ILE THR GLY MET LEU VAL MET PHE ALA PRO PHE PHE SEQRES 8 H 437 ILE PHE ILE PHE GLY PRO LEU LEU GLN TYR ASN ILE LEU SEQRES 9 H 437 VAL GLY SER ILE VAL GLY GLY ILE TYR LEU GLY PHE SER SEQRES 10 H 437 PHE ASN ALA GLY ALA PRO ALA VAL GLU ALA PHE ILE GLU SEQRES 11 H 437 LYS VAL SER ARG ARG SER ASN PHE GLU PHE GLY ARG ALA SEQRES 12 H 437 ARG MET PHE GLY ALA VAL GLY TRP ALA LEU VAL ALA SER SEQRES 13 H 437 ILE VAL GLY ILE MET PHE THR ILE ASN ASN GLN PHE VAL SEQRES 14 H 437 PHE TRP LEU GLY SER GLY MET ALA LEU ILE LEU ALA VAL SEQRES 15 H 437 LEU LEU PHE PHE ALA LYS THR ASP ALA PRO SER SER ALA SEQRES 16 H 437 THR VAL ALA ASN ALA VAL GLY ALA ASN HIS SER ALA PHE SEQRES 17 H 437 SER LEU LYS LEU ALA LEU GLU LEU PHE ARG GLN PRO LYS SEQRES 18 H 437 LEU TRP PHE LEU SER LEU TYR VAL ILE GLY VAL SER SER SEQRES 19 H 437 THR TYR ASP VAL PHE ASP GLN GLN PHE ALA ASN PHE PHE SEQRES 20 H 437 THR SER PHE PHE ALA THR GLY GLU GLN GLY THR ARG VAL SEQRES 21 H 437 PHE TRP TYR VAL THR THR MET GLY GLU LEU LEU ASN ALA SEQRES 22 H 437 SER ILE MET PHE PHE ALA PRO LEU ILE ILE ASN ARG ILE SEQRES 23 H 437 GLY GLY LYS ASN ALA LEU LEU LEU ALA GLY THR ILE MET SEQRES 24 H 437 SER VAL ARG ILE ILE GLY SER SER PHE ALA THR SER ALA SEQRES 25 H 437 LEU GLU VAL VAL ILE LEU LYS THR LEU HIS MET PHE GLU SEQRES 26 H 437 VAL PRO PHE LEU LEU VAL GLY SER PHE LYS TYR ILE THR SEQRES 27 H 437 SER GLN PHE GLU VAL ARG PHE SER ALA THR ILE TYR LEU SEQRES 28 H 437 VAL ALA PHE ALA PHE PHE LYS GLN LEU ALA MET ILE PHE SEQRES 29 H 437 MET SER VAL LEU ALA GLY ASN MET TYR GLU SER ILE GLY SEQRES 30 H 437 PHE GLN GLY ALA TYR LEU VAL LEU GLY LEU VAL ALA LEU SEQRES 31 H 437 GLY PHE THR LEU ILE SER VAL PHE THR LEU SER GLY PRO SEQRES 32 H 437 GLY PRO LEU SER LEU LEU ARG ARG GLN VAL ASN GLU VAL SEQRES 33 H 437 ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SER HIS HIS SEQRES 34 H 437 HIS HIS HIS HIS HIS HIS HIS HIS SEQRES 1 I 437 MET TYR TYR LEU LYS ASN THR ASN PHE TRP MET PHE GLY SEQRES 2 I 437 LEU PHE PHE PHE PHE TYR PHE PHE ILE MET GLY ALA TYR SEQRES 3 I 437 PHE PRO PHE PHE PRO ILE TRP LEU HIS ASP ILE ASN HIS SEQRES 4 I 437 ILE SER LYS SER ASP THR TRP ILE ILE PHE ALA ALA ILE SEQRES 5 I 437 SER LEU PHE SER LEU LEU PHE GLN PRO LEU PHE GLY LEU SEQRES 6 I 437 LEU SER ASP LYS LEU GLY LEU ARG LYS TYR LEU LEU TRP SEQRES 7 I 437 ILE ILE THR GLY MET LEU VAL MET PHE ALA PRO PHE PHE SEQRES 8 I 437 ILE PHE ILE PHE GLY PRO LEU LEU GLN TYR ASN ILE LEU SEQRES 9 I 437 VAL GLY SER ILE VAL GLY GLY ILE TYR LEU GLY PHE SER SEQRES 10 I 437 PHE ASN ALA GLY ALA PRO ALA VAL GLU ALA PHE ILE GLU SEQRES 11 I 437 LYS VAL SER ARG ARG SER ASN PHE GLU PHE GLY ARG ALA SEQRES 12 I 437 ARG MET PHE GLY ALA VAL GLY TRP ALA LEU VAL ALA SER SEQRES 13 I 437 ILE VAL GLY ILE MET PHE THR ILE ASN ASN GLN PHE VAL SEQRES 14 I 437 PHE TRP LEU GLY SER GLY MET ALA LEU ILE LEU ALA VAL SEQRES 15 I 437 LEU LEU PHE PHE ALA LYS THR ASP ALA PRO SER SER ALA SEQRES 16 I 437 THR VAL ALA ASN ALA VAL GLY ALA ASN HIS SER ALA PHE SEQRES 17 I 437 SER LEU LYS LEU ALA LEU GLU LEU PHE ARG GLN PRO LYS SEQRES 18 I 437 LEU TRP PHE LEU SER LEU TYR VAL ILE GLY VAL SER SER SEQRES 19 I 437 THR TYR ASP VAL PHE ASP GLN GLN PHE ALA ASN PHE PHE SEQRES 20 I 437 THR SER PHE PHE ALA THR GLY GLU GLN GLY THR ARG VAL SEQRES 21 I 437 PHE TRP TYR VAL THR THR MET GLY GLU LEU LEU ASN ALA SEQRES 22 I 437 SER ILE MET PHE PHE ALA PRO LEU ILE ILE ASN ARG ILE SEQRES 23 I 437 GLY GLY LYS ASN ALA LEU LEU LEU ALA GLY THR ILE MET SEQRES 24 I 437 SER VAL ARG ILE ILE GLY SER SER PHE ALA THR SER ALA SEQRES 25 I 437 LEU GLU VAL VAL ILE LEU LYS THR LEU HIS MET PHE GLU SEQRES 26 I 437 VAL PRO PHE LEU LEU VAL GLY SER PHE LYS TYR ILE THR SEQRES 27 I 437 SER GLN PHE GLU VAL ARG PHE SER ALA THR ILE TYR LEU SEQRES 28 I 437 VAL ALA PHE ALA PHE PHE LYS GLN LEU ALA MET ILE PHE SEQRES 29 I 437 MET SER VAL LEU ALA GLY ASN MET TYR GLU SER ILE GLY SEQRES 30 I 437 PHE GLN GLY ALA TYR LEU VAL LEU GLY LEU VAL ALA LEU SEQRES 31 I 437 GLY PHE THR LEU ILE SER VAL PHE THR LEU SER GLY PRO SEQRES 32 I 437 GLY PRO LEU SER LEU LEU ARG ARG GLN VAL ASN GLU VAL SEQRES 33 I 437 ALA TRP SER HIS PRO GLN PHE GLU LYS GLY SER HIS HIS SEQRES 34 I 437 HIS HIS HIS HIS HIS HIS HIS HIS HELIX 1 AA1 LYS A 2 GLY A 24 1 23 HELIX 2 AA2 GLU A 28 GLY A 42 1 15 HELIX 3 AA3 LYS A 43 GLY A 57 1 15 HELIX 4 AA4 THR A 59 MET A 72 1 14 HELIX 5 AA5 THR A 76 ASP A 90 1 15 HELIX 6 AA6 VAL A 93 LYS A 127 1 35 HELIX 7 AA7 SER A 136 GLY A 151 1 16 HELIX 8 AA8 ASP A 163 SER A 172 1 10 HELIX 9 AA9 VAL A 173 LYS A 175 5 3 HELIX 10 AB1 SER A 188 SER A 198 1 11 HELIX 11 AB2 ASP A 209 GLY A 220 1 12 HELIX 12 AB3 THR A 229 LEU A 239 1 11 HELIX 13 AB4 PRO A 248 GLY A 253 1 6 HELIX 14 AB5 GLY A 253 LYS A 261 1 9 HELIX 15 AB6 ASN A 279 GLY A 287 1 9 HELIX 16 AB7 GLY A 294 LYS A 299 1 6 HELIX 17 AB8 THR A 301 THR A 320 1 20 HELIX 18 AB9 GLU B 3 GLY B 24 1 22 HELIX 19 AC1 GLU B 28 GLY B 42 1 15 HELIX 20 AC2 LYS B 43 GLY B 57 1 15 HELIX 21 AC3 THR B 59 SER B 71 1 13 HELIX 22 AC4 THR B 76 ASP B 90 1 15 HELIX 23 AC5 VAL B 93 LYS B 127 1 35 HELIX 24 AC6 SER B 136 GLY B 151 1 16 HELIX 25 AC7 ASP B 163 SER B 172 1 10 HELIX 26 AC8 VAL B 173 GLY B 178 5 6 HELIX 27 AC9 SER B 188 SER B 198 1 11 HELIX 28 AD1 ASP B 209 GLY B 220 1 12 HELIX 29 AD2 THR B 229 LEU B 239 1 11 HELIX 30 AD3 PRO B 248 GLY B 253 1 6 HELIX 31 AD4 GLY B 253 LYS B 261 1 9 HELIX 32 AD5 ASN B 279 GLY B 287 1 9 HELIX 33 AD6 THR B 301 CYS B 319 1 19 HELIX 34 AD7 GLU C 3 GLY C 24 1 22 HELIX 35 AD8 GLU C 28 GLY C 42 1 15 HELIX 36 AD9 LYS C 43 GLY C 57 1 15 HELIX 37 AE1 THR C 59 SER C 71 1 13 HELIX 38 AE2 THR C 76 ASP C 90 1 15 HELIX 39 AE3 SER C 94 LYS C 127 1 34 HELIX 40 AE4 SER C 136 GLY C 151 1 16 HELIX 41 AE5 ASP C 163 SER C 172 1 10 HELIX 42 AE6 VAL C 173 LYS C 175 5 3 HELIX 43 AE7 SER C 188 SER C 198 1 11 HELIX 44 AE8 ASP C 209 GLY C 220 1 12 HELIX 45 AE9 THR C 229 LEU C 239 1 11 HELIX 46 AF1 PRO C 248 GLY C 253 1 6 HELIX 47 AF2 GLY C 253 MET C 260 1 8 HELIX 48 AF3 ASN C 279 GLY C 287 1 9 HELIX 49 AF4 THR C 301 THR C 320 1 20 HELIX 50 AF5 LYS D 88 THR D 92 5 5 HELIX 51 AF6 THR D 131 HIS D 145 1 15 HELIX 52 AF7 GLN D 149 ALA D 157 1 9 HELIX 53 AF8 ASN D 161 ALA D 174 1 14 HELIX 54 AF9 LEU D 179 ALA D 194 1 16 HELIX 55 AG1 SER D 195 ASP D 210 1 16 HELIX 56 AG2 ASP D 210 GLY D 225 1 16 HELIX 57 AG3 THR D 226 TRP D 249 1 24 HELIX 58 AG4 LYS E 88 THR E 92 5 5 HELIX 59 AG5 THR E 131 HIS E 145 1 15 HELIX 60 AG6 GLN E 149 ALA E 157 1 9 HELIX 61 AG7 ASN E 161 ALA E 174 1 14 HELIX 62 AG8 LEU E 179 ALA E 194 1 16 HELIX 63 AG9 SER E 195 ASP E 210 1 16 HELIX 64 AH1 ASP E 210 GLY E 225 1 16 HELIX 65 AH2 THR E 226 TRP E 249 1 24 HELIX 66 AH3 LYS F 88 THR F 92 5 5 HELIX 67 AH4 THR F 131 HIS F 145 1 15 HELIX 68 AH5 GLN F 149 ALA F 157 1 9 HELIX 69 AH6 ASN F 161 ALA F 174 1 14 HELIX 70 AH7 LEU F 179 ALA F 194 1 16 HELIX 71 AH8 SER F 195 ASP F 210 1 16 HELIX 72 AH9 ASP F 210 GLY F 225 1 16 HELIX 73 AI1 THR F 226 TRP F 249 1 24 HELIX 74 AI2 ASN G 6 ILE G 37 1 32 HELIX 75 AI3 SER G 41 ASP G 44 5 4 HELIX 76 AI4 THR G 45 GLY G 71 1 27 HELIX 77 AI5 TYR G 75 MET G 86 1 12 HELIX 78 AI6 MET G 86 ILE G 94 1 9 HELIX 79 AI7 PHE G 95 TYR G 101 1 7 HELIX 80 AI8 ASN G 102 PHE G 118 1 17 HELIX 81 AI9 ALA G 120 ASN G 137 1 18 HELIX 82 AJ1 ALA G 143 THR G 163 1 21 HELIX 83 AJ2 GLN G 167 PHE G 185 1 19 HELIX 84 AJ3 SER G 209 GLU G 215 1 7 HELIX 85 AJ4 LEU G 216 ARG G 218 5 3 HELIX 86 AJ5 GLN G 219 VAL G 232 1 14 HELIX 87 AJ6 VAL G 232 GLN G 241 1 10 HELIX 88 AJ7 GLN G 242 THR G 248 1 7 HELIX 89 AJ8 SER G 249 PHE G 251 5 3 HELIX 90 AJ9 THR G 253 PHE G 278 1 26 HELIX 91 AK1 PHE G 278 GLY G 287 1 10 HELIX 92 AK2 GLY G 287 ALA G 309 1 23 HELIX 93 AK3 SER G 311 LEU G 321 1 11 HELIX 94 AK4 GLU G 325 PHE G 341 1 17 HELIX 95 AK5 GLU G 342 ARG G 344 5 3 HELIX 96 AK6 PHE G 345 PHE G 354 1 10 HELIX 97 AK7 ALA G 355 ILE G 376 1 22 HELIX 98 AK8 ILE G 376 LEU G 400 1 25 HELIX 99 AK9 ASN H 6 ILE H 37 1 32 HELIX 100 AL1 SER H 41 ASP H 44 5 4 HELIX 101 AL2 THR H 45 GLY H 71 1 27 HELIX 102 AL3 TYR H 75 MET H 86 1 12 HELIX 103 AL4 MET H 86 ILE H 94 1 9 HELIX 104 AL5 PHE H 95 TYR H 101 1 7 HELIX 105 AL6 ASN H 102 PHE H 118 1 17 HELIX 106 AL7 ALA H 120 ASN H 137 1 18 HELIX 107 AL8 ALA H 143 THR H 163 1 21 HELIX 108 AL9 GLN H 167 PHE H 185 1 19 HELIX 109 AM1 SER H 209 GLU H 215 1 7 HELIX 110 AM2 LEU H 216 ARG H 218 5 3 HELIX 111 AM3 GLN H 219 VAL H 232 1 14 HELIX 112 AM4 VAL H 232 GLN H 241 1 10 HELIX 113 AM5 GLN H 242 THR H 248 1 7 HELIX 114 AM6 SER H 249 PHE H 251 5 3 HELIX 115 AM7 THR H 253 PHE H 278 1 26 HELIX 116 AM8 PHE H 278 GLY H 287 1 10 HELIX 117 AM9 GLY H 287 ALA H 309 1 23 HELIX 118 AN1 SER H 311 LEU H 321 1 11 HELIX 119 AN2 GLU H 325 PHE H 341 1 17 HELIX 120 AN3 GLU H 342 ARG H 344 5 3 HELIX 121 AN4 PHE H 345 PHE H 354 1 10 HELIX 122 AN5 ALA H 355 ILE H 376 1 22 HELIX 123 AN6 ILE H 376 LEU H 400 1 25 HELIX 124 AN7 ASN I 6 ILE I 37 1 32 HELIX 125 AN8 SER I 41 ASP I 44 5 4 HELIX 126 AN9 THR I 45 GLY I 71 1 27 HELIX 127 AO1 TYR I 75 MET I 86 1 12 HELIX 128 AO2 MET I 86 ILE I 94 1 9 HELIX 129 AO3 PHE I 95 TYR I 101 1 7 HELIX 130 AO4 ASN I 102 PHE I 118 1 17 HELIX 131 AO5 ALA I 120 ASN I 137 1 18 HELIX 132 AO6 ALA I 143 THR I 163 1 21 HELIX 133 AO7 GLN I 167 PHE I 185 1 19 HELIX 134 AO8 SER I 209 GLU I 215 1 7 HELIX 135 AO9 LEU I 216 ARG I 218 5 3 HELIX 136 AP1 GLN I 219 VAL I 232 1 14 HELIX 137 AP2 VAL I 232 GLN I 241 1 10 HELIX 138 AP3 GLN I 242 THR I 248 1 7 HELIX 139 AP4 SER I 249 PHE I 251 5 3 HELIX 140 AP5 THR I 253 PHE I 278 1 26 HELIX 141 AP6 PHE I 278 GLY I 287 1 10 HELIX 142 AP7 GLY I 287 ALA I 309 1 23 HELIX 143 AP8 SER I 311 LEU I 321 1 11 HELIX 144 AP9 GLU I 325 PHE I 341 1 17 HELIX 145 AQ1 GLU I 342 ARG I 344 5 3 HELIX 146 AQ2 PHE I 345 PHE I 354 1 10 HELIX 147 AQ3 ALA I 355 ILE I 376 1 22 HELIX 148 AQ4 ILE I 376 LEU I 400 1 25 SHEET 1 AA1 4 ILE A 180 GLY A 184 0 SHEET 2 AA1 4 LEU A 154 THR A 158 1 N ILE A 155 O ILE A 180 SHEET 3 AA1 4 ILE A 128 ALA A 130 1 N ALA A 130 O GLU A 156 SHEET 4 AA1 4 VAL A 291 VAL A 293 1 O VAL A 293 N VAL A 129 SHEET 1 AA2 2 PHE A 202 VAL A 204 0 SHEET 2 AA2 2 PHE A 222 MET A 224 1 O MET A 224 N ILE A 203 SHEET 1 AA3 3 GLY A 226 VAL A 227 0 SHEET 2 AA3 3 ILE A 243 LEU A 246 1 O LYS A 245 N VAL A 227 SHEET 3 AA3 3 LYS A 268 PHE A 269 1 O LYS A 268 N LEU A 244 SHEET 1 AA4 4 ILE B 180 GLY B 184 0 SHEET 2 AA4 4 LEU B 154 THR B 158 1 N ILE B 157 O GLY B 182 SHEET 3 AA4 4 VAL B 129 LEU B 132 1 N LEU B 132 O GLU B 156 SHEET 4 AA4 4 GLY B 292 VAL B 293 1 O VAL B 293 N VAL B 131 SHEET 1 AA5 2 PHE B 202 VAL B 204 0 SHEET 2 AA5 2 PHE B 222 MET B 224 1 O MET B 224 N ILE B 203 SHEET 1 AA6 3 GLY B 226 VAL B 227 0 SHEET 2 AA6 3 ILE B 243 LEU B 246 1 O LYS B 245 N VAL B 227 SHEET 3 AA6 3 LYS B 268 PHE B 269 1 O LYS B 268 N LEU B 244 SHEET 1 AA7 4 ILE C 180 GLY C 184 0 SHEET 2 AA7 4 LEU C 154 THR C 158 1 N ILE C 155 O ILE C 180 SHEET 3 AA7 4 VAL C 129 LEU C 132 1 N ALA C 130 O GLU C 156 SHEET 4 AA7 4 GLY C 292 VAL C 293 1 O VAL C 293 N VAL C 131 SHEET 1 AA8 2 PHE C 202 VAL C 204 0 SHEET 2 AA8 2 PHE C 222 MET C 224 1 O MET C 224 N ILE C 203 SHEET 1 AA9 3 GLY C 226 VAL C 227 0 SHEET 2 AA9 3 ILE C 243 LEU C 246 1 O LYS C 245 N VAL C 227 SHEET 3 AA9 3 LYS C 268 PRO C 271 1 O LYS C 268 N LEU C 244 SHEET 1 AB1 4 VAL D 3 SER D 8 0 SHEET 2 AB1 4 LEU D 19 GLY D 27 -1 O SER D 26 N GLN D 4 SHEET 3 AB1 4 THR D 79 MET D 84 -1 O LEU D 82 N LEU D 21 SHEET 4 AB1 4 PHE D 69 ARG D 73 -1 N THR D 70 O GLN D 83 SHEET 1 AB2 6 LEU D 12 VAL D 13 0 SHEET 2 AB2 6 THR D 124 VAL D 128 1 O ALA D 127 N VAL D 13 SHEET 3 AB2 6 ALA D 93 ALA D 100 -1 N TYR D 95 O THR D 124 SHEET 4 AB2 6 LEU D 34 GLN D 40 -1 N PHE D 38 O TYR D 96 SHEET 5 AB2 6 GLU D 47 ARG D 53 -1 O ALA D 50 N TRP D 37 SHEET 6 AB2 6 THR D 59 TYR D 61 -1 O TYR D 60 N ALA D 51 SHEET 1 AB3 4 LEU D 12 VAL D 13 0 SHEET 2 AB3 4 THR D 124 VAL D 128 1 O ALA D 127 N VAL D 13 SHEET 3 AB3 4 ALA D 93 ALA D 100 -1 N TYR D 95 O THR D 124 SHEET 4 AB3 4 TYR D 119 TRP D 120 -1 O TYR D 119 N ALA D 99 SHEET 1 AB4 4 VAL E 3 SER E 8 0 SHEET 2 AB4 4 LEU E 19 GLY E 27 -1 O SER E 26 N GLN E 4 SHEET 3 AB4 4 THR E 79 MET E 84 -1 O LEU E 82 N LEU E 21 SHEET 4 AB4 4 PHE E 69 ARG E 73 -1 N THR E 70 O GLN E 83 SHEET 1 AB5 6 LEU E 12 VAL E 13 0 SHEET 2 AB5 6 THR E 124 VAL E 128 1 O ALA E 127 N VAL E 13 SHEET 3 AB5 6 ALA E 93 ALA E 100 -1 N TYR E 95 O THR E 124 SHEET 4 AB5 6 LEU E 34 GLN E 40 -1 N PHE E 38 O TYR E 96 SHEET 5 AB5 6 GLU E 47 ARG E 53 -1 O ALA E 50 N TRP E 37 SHEET 6 AB5 6 THR E 59 TYR E 61 -1 O TYR E 60 N ALA E 51 SHEET 1 AB6 4 LEU E 12 VAL E 13 0 SHEET 2 AB6 4 THR E 124 VAL E 128 1 O ALA E 127 N VAL E 13 SHEET 3 AB6 4 ALA E 93 ALA E 100 -1 N TYR E 95 O THR E 124 SHEET 4 AB6 4 TYR E 119 TRP E 120 -1 O TYR E 119 N ALA E 99 SHEET 1 AB7 4 VAL F 3 SER F 8 0 SHEET 2 AB7 4 LEU F 19 GLY F 27 -1 O SER F 26 N GLN F 4 SHEET 3 AB7 4 THR F 79 MET F 84 -1 O LEU F 82 N LEU F 21 SHEET 4 AB7 4 PHE F 69 ARG F 73 -1 N THR F 70 O GLN F 83 SHEET 1 AB8 6 LEU F 12 VAL F 13 0 SHEET 2 AB8 6 THR F 124 VAL F 128 1 O ALA F 127 N VAL F 13 SHEET 3 AB8 6 ALA F 93 ALA F 100 -1 N TYR F 95 O THR F 124 SHEET 4 AB8 6 LEU F 34 GLN F 40 -1 N PHE F 38 O TYR F 96 SHEET 5 AB8 6 GLU F 47 ARG F 53 -1 O ALA F 50 N TRP F 37 SHEET 6 AB8 6 THR F 59 TYR F 61 -1 O TYR F 60 N ALA F 51 SHEET 1 AB9 4 LEU F 12 VAL F 13 0 SHEET 2 AB9 4 THR F 124 VAL F 128 1 O ALA F 127 N VAL F 13 SHEET 3 AB9 4 ALA F 93 ALA F 100 -1 N TYR F 95 O THR F 124 SHEET 4 AB9 4 TYR F 119 TRP F 120 -1 O TYR F 119 N ALA F 99 SSBOND 1 CYS A 281 CYS A 319 1555 1555 2.03 SSBOND 2 CYS B 281 CYS B 319 1555 1555 2.03 SSBOND 3 CYS C 281 CYS C 319 1555 1555 2.03 SSBOND 4 CYS D 23 CYS D 97 1555 1555 2.03 SSBOND 5 CYS E 23 CYS E 97 1555 1555 2.03 SSBOND 6 CYS F 23 CYS F 97 1555 1555 2.03 CISPEP 1 PHE A 247 PRO A 248 0 -3.92 CISPEP 2 PHE B 247 PRO B 248 0 -3.58 CISPEP 3 PHE C 247 PRO C 248 0 -4.13 CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 1.000000 0.000000 0.000000 0.00000 SCALE2 0.000000 1.000000 0.000000 0.00000 SCALE3 0.000000 0.000000 1.000000 0.00000