pdb Hchain Lchain model antigen_chain antigen_type antigen_het_name antigen_name short_header date compound organism heavy_species light_species antigen_species authors resolution method r_free r_factor scfv engineered heavy_subclass light_subclass light_ctype affinity delta_g affinity_method temperature pmid 9jy3 P O 0 e protein NA unknown IMMUNE SYSTEM 04/15/26 delta epsilon/gamma epsilon Fab-TCR tetramer Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9jy3 R Q 0 F protein NA t-cell surface glycoprotein cd3 epsilon chain IMMUNE SYSTEM 04/15/26 delta epsilon/gamma epsilon Fab-TCR tetramer Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9jy4 P O 0 f protein NA unknown IMMUNE SYSTEM 04/15/26 gamma epsilon/gamma epsilon Fab-TCR tetramer Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9jy4 R Q 0 F protein NA t-cell surface glycoprotein cd3 epsilon chain IMMUNE SYSTEM 04/15/26 gamma epsilon/gamma epsilon Fab-TCR tetramer Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9q7b G I 0 F | A protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles Virus Fusion Glycoprotein Ectodomain in Prefusion Conformation Bound to Neutralizing Antibody H8 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9q7b J K 0 B | C protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles Virus Fusion Glycoprotein Ectodomain in Prefusion Conformation Bound to Neutralizing Antibody H8 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9q7b L M 0 D | E protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles Virus Fusion Glycoprotein Ectodomain in Prefusion Conformation Bound to Neutralizing Antibody H8 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9q71 G H 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles Virus Fusion Glycoprotein Ectodomain in Postfusion Conformation Bound to Neutralizing Antibody H8 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9q71 I J 0 F protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles Virus Fusion Glycoprotein Ectodomain in Postfusion Conformation Bound to Neutralizing Antibody H8 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9q71 K L 0 D protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles Virus Fusion Glycoprotein Ectodomain in Postfusion Conformation Bound to Neutralizing Antibody H8 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9q5v I G 0 D protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles virus Fusion glycoprotein ectodomain in complex with two neutralizing antibodies mAb77 and Y10F Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9q5v K J 0 F | B | E protein | protein | protein NA | NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles virus Fusion glycoprotein ectodomain in complex with two neutralizing antibodies mAb77 and Y10F Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus | measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV16 Kappa None None None None None 11sz C D 0 B protein NA 6-deoxyerythronolide-b synthase, erythronolide synthaseerya2 BIOSYNTHETIC PROTEIN/Immune System 04/15/26 Antibody (1B2) Bound Rifamycin Synthetase Module 2 Amycolatopsis mediterranei; Homo sapiens homo sapiens homo sapiens amycolatopsis mediterranei Cogan, D.P. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 11sz H L 0 A protein NA 6-deoxyerythronolide-b synthase, erythronolide synthaseerya2 BIOSYNTHETIC PROTEIN/Immune System 04/15/26 Antibody (1B2) Bound Rifamycin Synthetase Module 2 Amycolatopsis mediterranei; Homo sapiens homo sapiens homo sapiens amycolatopsis mediterranei Cogan, D.P. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 22gi D A 0 F peptide NA ala-val-val-asn-gln-asn VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 3D1 Fab in complex with pepAVVNQN Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens coroavirus Lei, Y. 2.64 X-RAY DIFFRACTION 0.296 0.212 False True IGHV7 IGLV2 Lambda None None None None None 22gi C B 0 E peptide NA ala-val-val-asn-gln-asn VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 3D1 Fab in complex with pepAVVNQN Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens coroavirus Lei, Y. 2.64 X-RAY DIFFRACTION 0.296 0.212 False True IGHV7 IGLV2 Lambda None None None None None 22gi H G 0 I peptide NA ala-val-val-asn-gln-asn VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 3D1 Fab in complex with pepAVVNQN Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens coroavirus Lei, Y. 2.64 X-RAY DIFFRACTION 0.296 0.212 False True IGHV7 IGLV2 Lambda None None None None None 22gi K J 0 L peptide NA ala-val-val-asn-gln-asn VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 3D1 Fab in complex with pepAVVNQN Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens coroavirus Lei, Y. 2.64 X-RAY DIFFRACTION 0.296 0.212 False True IGHV7 IGLV2 Lambda None None None None None 9q5m I G 0 F | E | D | C | B protein | protein | protein | protein | protein NA | NA | NA | NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 | fusion glycoprotein f0 | fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Structure of the Measles virus Fusion glycoprotein ectodomain in complex with neutralizing antibody Y10F Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus | measles morbillivirus | measles morbillivirus | measles morbillivirus Zyla, D., Niemeyer, G., Porotto, M., Saphire, E.O. 2.59 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9qqe H L 0 A | P protein | peptide NA | NA mhc class i antigen | peptide vlhddllea IMMUNE SYSTEM 04/15/26 Cryo-EM structure of the SN230G6 Fab - HLA-A*02:01 human alloantibody-HLA complex Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Zampieri, V., Priddey, A., Schneider, S., Heidt, S., Kosmoliaptsis, V., Marquez, J.A. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9qqf H L 0 A protein NA mhc class i antigen IMMUNE SYSTEM 04/15/26 Cryo-EM structure of the WIM8E5 Fab - HLA-A*11:01 human alloantibody-HLA complex Homo sapiens homo sapiens homo sapiens homo sapiens Zampieri, V., Priddey, A., Humm, A.S., Pellegrini, E., Heidt, S., Kosmoliaptsis, V., Marquez, J.A. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9udq F A 0 J protein NA protein opg161 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Crystal structure of MPXV A35R in complex with a neutralizing antibody MA42 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Sun, D., Zhang, N., Guo, Y. 2.82 X-RAY DIFFRACTION 0.275 0.212 False True IGHV3 IGKV1 Kappa None None None None None 9udq I C 0 B protein NA protein opg161 VIRAL PROTEIN/IMMUNE SYSTEM 04/15/26 Crystal structure of MPXV A35R in complex with a neutralizing antibody MA42 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Sun, D., Zhang, N., Guo, Y. 2.82 X-RAY DIFFRACTION 0.275 0.212 False True IGHV3 IGKV1 Kappa None None None None None 9x3z S s 0 A | B protein | protein NA | NA chimeric gi protein | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PEPTIDE BINDING PROTEIN 04/15/26 NPFF bound Mas1 Receptor Complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Zhang, Y.M., Liu, H., Xu, H.E. 2.54 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9xyb H L 0 E protein NA envelope protein e VIRAL PROTEIN 04/15/26 Crystal structure of a ZIKV E glycoprotein DI-DIII vaccine candidate in complex with human neutralizing antibody MZ4 Homo sapiens; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Jensen, J.L., Joyce, M.G. 2.85 X-RAY DIFFRACTION 0.316 0.235 False True IGHV4 IGLV1 Lambda None None None None None 11ol H L 0 A protein NA sars-cov-2 omicron ba.4 spike protein IMMUNE SYSTEM/Viral Protein 04/08/26 SARS-CoV-2 Omicron BA.4 RBD in complex with Omi32 Fab and LC-Kappa VHH Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 11ol K NA 0 NA NA NA NA IMMUNE SYSTEM/Viral Protein 04/08/26 SARS-CoV-2 Omicron BA.4 RBD in complex with Omi32 Fab and LC-Kappa VHH Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus lama glama Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 11oo H L 0 A protein NA sars-cov-2 omicron ba.4 spike protein IMMUNE SYSTEM/Viral Protein 04/08/26 SARS-CoV-2 Omicron BA.4 RBD in complex with Omi32 germline Fab and LC-Kappa VHH Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 11oo K NA 0 NA NA NA NA IMMUNE SYSTEM/Viral Protein 04/08/26 SARS-CoV-2 Omicron BA.4 RBD in complex with Omi32 germline Fab and LC-Kappa VHH Homo sapiens; Lama glama lama glama Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 11oq H L 0 A protein NA sars-cov-2 omicron ba.1 spike protein IMMUNE SYSTEM/Viral Protein 04/08/26 SARS-CoV-2 Omicron BA.1 RBD in complex with Omi32 germline Fab and LC-Kappa VHH Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 11oq K NA 0 NA NA NA NA IMMUNE SYSTEM/Viral Protein 04/08/26 SARS-CoV-2 Omicron BA.1 RBD in complex with Omi32 germline Fab and LC-Kappa VHH Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 11or H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Omi32 Fab in complex with LC-Kappa VHH Homo sapiens; Lama glama homo sapiens homo sapiens Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 11or K NA 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Omi32 Fab in complex with LC-Kappa VHH Homo sapiens; Lama glama lama glama Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 11ou H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Omi32 germline Fab in complex with LC-Kappa VHH Homo sapiens; Lama glama homo sapiens homo sapiens Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 11ou K NA 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Omi32 germline Fab in complex with LC-Kappa VHH Homo sapiens; Lama glama lama glama Kang, G., Phillips, A.M., Catalano, C., Scapin, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9dsg H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 04/08/26 Crystal structure of the SARS-CoV-2 RBD in complex with the cow antibody P2 Bos taurus; Severe acute respiratory syndrome coronavirus 2 bos taurus bos taurus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.4 X-RAY DIFFRACTION 0.263 0.222 False True IGHV1 IGLV1 Lambda None None None None None 9dsh H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Crystal structure of the cow antibody P7 Bos taurus bos taurus bos taurus Fan, C., Bjorkman, P.J. 1.7 X-RAY DIFFRACTION 0.223 0.181 False True IGHV1 IGLV1 Lambda None None None None None 9dsi H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Crystal structure of the cow antibody 99 Bos taurus bos taurus bos taurus Fan, C., Bjorkman, P.J. 2.8 X-RAY DIFFRACTION 0.267 0.229 False True IGHV1 IGLV1 Lambda None None None None None 9dsj H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Crystal structure of the cow antibody 105 Bos taurus bos taurus bos taurus Fan, C., Bjorkman, P.J. 1.65 X-RAY DIFFRACTION 0.211 0.167 False True IGHV1 IGLV1 Lambda None None None None None 9dsk H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 Crystal structure of the cow antibody 115 Bos taurus bos taurus bos taurus Fan, C., Bjorkman, P.J. 1.7 X-RAY DIFFRACTION 0.228 0.169 False True IGHV1 IGLV1 Lambda None None None None None 9dsl H L 0 C | B protein | protein NA | NA spike glycoprotein | spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 04/08/26 Structure of the SARS-CoV-2 S 6P trimer in complex with the cow antibody 99 Fab Bos taurus; Severe acute respiratory syndrome coronavirus 2 bos taurus bos taurus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9nzf H L 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 04/08/26 Crystal structure of Fab MAM01 in complex with minor repeat region peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 1.84 X-RAY DIFFRACTION 0.230 0.190 False True IGHV3 IGLV1 Lambda None None None None None 9rye C NA 0 B protein NA multidrug resistance abc transporter atp-binding andpermease protein MEMBRANE PROTEIN 04/08/26 Heterodimeric ABC exporter TmrAB (EQ mutant) in ATP-bound outward-facing occluded conformation in the absence of Mg2+ Thermus thermophilus; Vicugna pacos vicugna pacos thermus thermophilus Susac, L., Nocker, C., Tampe, R. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ryf C NA 0 B protein NA multidrug resistance abc transporter atp-binding andpermease protein MEMBRANE PROTEIN 04/08/26 Heterodimeric ABC exporter TmrAB (wild type) in ATP-bound outward-facing occluded conformation in the absence of Mg2+ Thermus thermophilus; Vicugna pacos vicugna pacos thermus thermophilus Susac, L., Nocker, C., Tampe, R. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9u35 K M 0 B | A protein | protein NA | NA envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 Helical Reconstruction of DENV2 THSTI/TRC/01 tubular particles bound with D14.F25.S02 fab dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 | dengue virus type 2 Chatterjee, A., Prasad, V.M. 17.37 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9uax A B 0 L protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and AS4C_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9uax C D 0 K protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and AS4C_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9uax E F 0 I protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and AS4C_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9uax G H 0 J protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and AS4C_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ub1 E F 0 C protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and M6B12_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ub1 G H 0 D protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and M6B12_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ub1 I J 0 B protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and M6B12_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ub1 K L 0 A protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/08/26 The structure of Myanmar_N2 and M6B12_Fab complex Homo sapiens; Influenza A virus (A/California/VRDL364/2009(mixed)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/vrdl364/2009(mixed)) Sun, J.Q., Yang, H. 2.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ucg A B 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 A Fab structure with a covalent bond Homo sapiens homo sapiens homo sapiens Makabe, K., Nakanishi, T. 2.65 X-RAY DIFFRACTION 0.281 0.220 False True IGHV4 IGKV3 Kappa None None None None None 9ucg C D 0 NA NA NA NA IMMUNE SYSTEM 04/08/26 A Fab structure with a covalent bond Homo sapiens homo sapiens homo sapiens Makabe, K., Nakanishi, T. 2.65 X-RAY DIFFRACTION 0.281 0.220 False True IGHV4 IGKV3 Kappa None None None None None 9mav H L 0 C protein NA envelope glycoprotein e VIRUS 04/01/26 Cryo-EM structure of Dengue virus serotype2 US/BID-V594/2006 strain bound with J9 fab. dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Roy, A., Prasad, V.M. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mav K M 0 A | E protein | protein NA | NA envelope glycoprotein e | envelope glycoprotein e VIRUS 04/01/26 Cryo-EM structure of Dengue virus serotype2 US/BID-V594/2006 strain bound with J9 fab. dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 | dengue virus type 2 Roy, A., Prasad, V.M. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mb0 H L 0 A protein NA envelope glycoprotein VIRUS 04/01/26 Cryo-EM structure of Dengue virus serotype2 THSTI/TRC/01 strain bound with J9 fab dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Roy, A., Prasad, V.M. 7.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mb0 K M 0 C | E protein | protein NA | NA envelope glycoprotein | envelope glycoprotein VIRUS 04/01/26 Cryo-EM structure of Dengue virus serotype2 THSTI/TRC/01 strain bound with J9 fab dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 | dengue virus type 2 Roy, A., Prasad, V.M. 7.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 11td H L 0 R protein NA c-c chemokine receptor type 4,soluble cytochrome b562 MEMBRANE PROTEIN 04/01/26 Structure of human CCR4 in apo state Escherichia coli; Homo sapiens homo sapiens homo sapiens homo sapiens, escherichia coli Qi, X., Zhou, N., Wang, R. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9maz H L 0 A protein NA envelope glycoprotein e VIRAL PROTEIN/IMMUNE SYSTEM 04/01/26 Helical Reconstruction of DENV2 US/BID-V594/2006 tubular particles bound with J9 fab dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Roy, A., Prasad, V.M. 38.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9maz K M 0 C protein NA envelope glycoprotein e VIRAL PROTEIN/IMMUNE SYSTEM 04/01/26 Helical Reconstruction of DENV2 US/BID-V594/2006 tubular particles bound with J9 fab dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Roy, A., Prasad, V.M. 38.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9np0 B C 0 A protein NA annexin a1 PROTEIN BINDING/IMMUNE SYSTEM 04/01/26 Structure of human annexin A1 in complex with 2C1 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Nadezhdin, K.D., Sobolevsky, A.I. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV6 Kappa None None None None None 9nvw H L 0 f | d | b protein | protein | protein NA | NA | NA unknown | unknown | unknown VIRAL PROTEIN/IMMUNE SYSTEM 04/01/26 Cryo-EM structure of rhesus antibody CH35-Apex1.08 in complex with HIV Env trimer Q23-APEX-GT2 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9nvx H L 0 d | b | f protein | protein | protein NA | NA | NA unknown | unknown | unknown VIRAL PROTEIN/IMMUNE SYSTEM 04/01/26 Cryo-EM structure of rhesus antibody CI91-Apex1.01 in complex with HIV Env trimer Q23-APEX-GT2 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9nvz H L 0 f | d | b protein | protein | protein NA | NA | NA unknown | unknown | unknown VIRAL PROTEIN/IMMUNE SYSTEM 04/01/26 Cryo-EM structure of rhesus antibody CH70-Apex1.01 in complex with HIV Env trimer Q23-APEX-GT2 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9nw0 H L 0 f | d | b protein | protein | protein NA | NA | NA unknown | unknown | unknown VIRAL PROTEIN/IMMUNE SYSTEM 04/01/26 Cryo-EM structure of rhesus antibody CH42-Apex1.01 in complex with HIV Env trimer Q23-APEX-GT2 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 9q7y D C 0 B protein NA disintegrin and metalloproteinase domain-containing protein17 MEMBRANE PROTEIN 04/01/26 Zymogen ADAM17- iRhom1 Cytoplasmic Deletion (365) Complex Bound by the MEDI3622 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Seegar, T.M., Maciag, J.J., Ungvary, J.N. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9xy4 D C 0 B protein NA disintegrin and metalloproteinase domain-containing protein17 SIGNALING PROTEIN 04/01/26 Zymogen ADAM17- iRhom1 Cytoplasmic Deletion (370) Complex Bound by the MEDI3622 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ungvary, J.N., Maciag, J.J., Seegar, T.C.M. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 10en F E 0 C | D protein | protein NA | NA isoform 4 of glutamate receptor ionotropic, nmda 1 | glutamate receptor SIGNALING PROTEIN/Immune System 03/25/26 SK3D-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 10en J I 0 A | B protein | protein NA | NA isoform 4 of glutamate receptor ionotropic, nmda 1 | glutamate receptor SIGNALING PROTEIN/Immune System 03/25/26 SK3D-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 10ex F E 0 D | C protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | isoform 4 of glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 SK5A-Matured apo state in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 4.08 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV9 Kappa None None None None None 10ex J I 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | isoform 4 of glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 SK5A-Matured apo state in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 4.08 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV9 Kappa None None None None None 10ez F E 0 A | B protein | protein NA | NA glutamate receptor ionotropic, nmda 1 | glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/Immune System 03/25/26 SK3D-Germline in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 10ez J I 0 C | D protein | protein NA | NA glutamate receptor ionotropic, nmda 1 | glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/Immune System 03/25/26 SK3D-Germline in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 10ff F E 0 D | C protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 SK5A-Matured glycine/glutamate in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 4.06 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV9 Kappa None None None None None 10ff J I 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 SK5A-Matured glycine/glutamate in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 4.06 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV9 Kappa None None None None None 10fn F E 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 SK5A-Germline in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 4.52 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV9 Kappa None None None None None 10fn J I 0 D | C protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 SK5A-Germline in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kleeman, S.O., Furukawa, H.F. 4.52 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV9 Kappa None None None None None 9nw5 H L 0 NA NA NA NA IMMUNE SYSTEM 03/25/26 3H4v31 anti-HLA-E-VL9 Fab Mus musculus mus musculus mus musculus Wrapp, D., Hwang, J.K., Marston, D.J., Haynes, B.F., Azoitei, M.L. 2.05 X-RAY DIFFRACTION 0.244 0.215 False True IGHV1 IGKV14 Kappa None None None None None 9nw6 E I 0 C | F protein | peptide NA | NA hla class i histocompatibility antigen, alpha chain e | vl9 peptide IMMUNE SYSTEM 03/25/26 CA147v24 Fab bound to HLA-E-VL9 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Wrapp, D., Hwang, J.K., Marston, D.J., Haynes, B.F., Azoitei, M.L. 3.1 X-RAY DIFFRACTION 0.258 0.239 False True IGHV3 IGKV3 Kappa None None None None None 9nw6 G H 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen, alpha chain e | vl9 peptide IMMUNE SYSTEM 03/25/26 CA147v24 Fab bound to HLA-E-VL9 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Wrapp, D., Hwang, J.K., Marston, D.J., Haynes, B.F., Azoitei, M.L. 3.1 X-RAY DIFFRACTION 0.258 0.239 False True IGHV3 IGKV3 Kappa None None None None None 9nw7 H L 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen, alpha chain e | vl9 peptide IMMUNE SYSTEM 03/25/26 CA117v2v8 Fab bound to HLA-E-VL9 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Wrapp, D., Hwang, J.K., Marston, D.J., Haynes, B.F., Azoitei, M.L. 2.1 X-RAY DIFFRACTION 0.233 0.189 False True IGHV4 IGLV2 Lambda None None None None None 9nw8 H L 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen, alpha chain e | mtb44 peptide IMMUNE SYSTEM 03/25/26 CA117v2v8 Fab bound to HLA-E-Mtb44 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | mycobacterium tuberculosis Wrapp, D., Hwang, J.K., Marston, D.J., Haynes, B.F., Azoitei, M.L. 2.3 X-RAY DIFFRACTION 0.246 0.196 False True IGHV4 IGLV2 Lambda None None None None None 9nw9 H L 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen, alpha chain e | rl9hiv peptide IMMUNE SYSTEM 03/25/26 CA117v2v8 Fab bound to HLA-E-RL9HIV Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | human immunodeficiency virus 1 Wrapp, D., Hwang, J.K., Marston, D.J., Haynes, B.F., Azoitei, M.L. 2.3 X-RAY DIFFRACTION 0.239 0.191 False True IGHV4 IGLV2 Lambda None None None None None 9u5p B C 0 A | R protein | nucleic-acid NA | NA protease 3c | rna (83-mer) RNA BINDING PROTEIN/RNA 03/25/26 HRV14 3C in complex with single chain antibody YDF and cloverleafRNA-dimer conformation Homo sapiens; rhinovirus B14; SYNTHETIC CONSTRUCT homo sapiens homo sapiens rhinovirus b14 | rhinovirus b14 Yang, B., Wang, Q., Sun, S.W., Zhang, X. 2.96 ELECTRON MICROSCOPY NA NA True True IGHV3 IGLV3 Lambda None None None None None 9u5p P Q 0 O protein NA protease 3c RNA BINDING PROTEIN/RNA 03/25/26 HRV14 3C in complex with single chain antibody YDF and cloverleafRNA-dimer conformation Homo sapiens; rhinovirus B14; SYNTHETIC CONSTRUCT homo sapiens homo sapiens rhinovirus b14 Yang, B., Wang, Q., Sun, S.W., Zhang, X. 2.96 ELECTRON MICROSCOPY NA NA True True IGHV3 IGLV3 Lambda None None None None None 9zqa J j 0 A | F | C protein | protein | protein NA | NA | NA histone h2a | histone h3 | histone h2b DNA BINDING PROTEIN/DNA 03/25/26 Nucleosome with an SSB at SHL -2.8 in complex with the WGR domain of human PARP2, Class 2 Drosophila melanogaster; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Kim, T.H., Jayathilake, C., Virk, R.K., Gregory-Lott, E.R. 3.28 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9zqa I i 0 B | E | D protein | protein | protein NA | NA | NA histone h2a | histone h3 | histone h2b DNA BINDING PROTEIN/DNA 03/25/26 Nucleosome with an SSB at SHL -2.8 in complex with the WGR domain of human PARP2, Class 2 Drosophila melanogaster; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Kim, T.H., Jayathilake, C., Virk, R.K., Gregory-Lott, E.R. 3.28 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9zqb I i 0 B | E | D | G protein | protein | protein | protein NA | NA | NA | NA histone h2a | histone h3 | histone h2b | histone h4 DNA BINDING PROTEIN/DNA 03/25/26 Nucleosome with an SSB at SHL -2.8 in complex with human PARP2 and HPF1, Class 1 Drosophila melanogaster; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Kim, T.H., Jayathilake, C., Virk, R.K., Gregory-Lott, E.R. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9zqb J j 0 A | F | H | C protein | protein | protein | protein NA | NA | NA | NA histone h2a | histone h3 | histone h4 | histone h2b DNA BINDING PROTEIN/DNA 03/25/26 Nucleosome with an SSB at SHL -2.8 in complex with human PARP2 and HPF1, Class 1 Drosophila melanogaster; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Kim, T.H., Jayathilake, C., Virk, R.K., Gregory-Lott, E.R. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9zqc I i 0 B | E | D | G protein | protein | protein | protein NA | NA | NA | NA histone h2a | histone h3 | histone h2b | histone h4 DNA BINDING PROTEIN/DNA 03/25/26 Nucleosome with an SSB at SHL -2.8 in complex with human PARP2 and HPF1, Class 2 Drosophila melanogaster; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Kim, T.H., Jayathilake, C., Virk, R.K., Gregory-Lott, E.R. 2.37 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9zqc J j 0 A | F | C protein | protein | protein NA | NA | NA histone h2a | histone h3 | histone h2b DNA BINDING PROTEIN/DNA 03/25/26 Nucleosome with an SSB at SHL -2.8 in complex with human PARP2 and HPF1, Class 2 Drosophila melanogaster; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Kim, T.H., Jayathilake, C., Virk, R.K., Gregory-Lott, E.R. 2.37 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 10ev F G 0 A protein NA isoform 4 of glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 OX1-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens homo sapiens homo sapiens homo sapiens Kleeman, S.O., Furukawa, H.F. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 10ev H I 0 C protein NA isoform 4 of glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 OX1-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens homo sapiens homo sapiens homo sapiens Kleeman, S.O., Furukawa, H.F. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 10ey F E 0 C protein NA glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Imuune System 03/25/26 SK5B-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kleeman, S.O., Furukawa, H.F. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV3 Kappa None None None None None 10ey J I 0 A protein NA glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Imuune System 03/25/26 SK5B-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kleeman, S.O., Furukawa, H.F. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV3 Kappa None None None None None 10fd F E 0 D protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/Immune System 03/25/26 SK5G-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kleeman, S.O., Furukawa, H.F. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 10fd J I 0 B protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/Immune System 03/25/26 SK5G-Matured in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kleeman, S.O., Furukawa, H.F. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 10fe F G 0 C protein NA glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 OX1-Germline in complex with GluN1-GluN2B, full refinement Homo sapiens homo sapiens homo sapiens homo sapiens Kleeman, S.O., Furukawa, H.F. 4.55 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 10fe H I 0 A protein NA glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/Immune System 03/25/26 OX1-Germline in complex with GluN1-GluN2B, full refinement Homo sapiens homo sapiens homo sapiens homo sapiens Kleeman, S.O., Furukawa, H.F. 4.55 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 10fl F E 0 D protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/Immune System 03/25/26 SK5G-Germline Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kleeman, S.O., Furukawa, H.F. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 10fo F E 0 D protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/Immune System 03/25/26 SK5B-Germline in complex with GluN1-GluN2B, full refinement Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kleeman, S.O., Furukawa, H.F. 4.46 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV3 Kappa None None None None None 10zo A NA 0 B protein NA nucleoprotein IMMUNE SYSTEM/VIRAL PROTEIN 03/25/26 Crystal structure of Mengla virus nucleoprotein bound by a cross-reactive anti-Marburg virus nanobody Dianlovirus menglaense; Lama glama lama glama dianlovirus menglaense Taylor, A.B., Olsen, S.K. 1.65 X-RAY DIFFRACTION 0.214 0.163 False True unknown unknown unknown None None None None None 10zo C NA 0 D protein NA nucleoprotein IMMUNE SYSTEM/VIRAL PROTEIN 03/25/26 Crystal structure of Mengla virus nucleoprotein bound by a cross-reactive anti-Marburg virus nanobody Dianlovirus menglaense; Lama glama lama glama dianlovirus menglaense Taylor, A.B., Olsen, S.K. 1.65 X-RAY DIFFRACTION 0.214 0.163 False True unknown unknown unknown None None None None None 9jkr A B 0 I protein NA granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 03/25/26 human GM-CSF with Fabs from autoantibodies, F1 and C. Homo sapiens homo sapiens homo sapiens homo sapiens Kishikawa, J., Kato, T., Kurosaki, T., Inoue, T. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9jkr C D 0 I protein NA granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 03/25/26 human GM-CSF with Fabs from autoantibodies, F1 and C. Homo sapiens homo sapiens homo sapiens homo sapiens Kishikawa, J., Kato, T., Kurosaki, T., Inoue, T. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9nw4 A B 0 C peptide NA pvcspvk210 peptide from circumsporozoite protein IMMUNE SYSTEM 03/25/26 Structure of CISV1 antibody bound to PvCSP repeat peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium vivax Hurlburt, N.K., Pancera, M. 1.82 X-RAY DIFFRACTION 0.215 0.183 False True IGHV3 IGKV4 Kappa None None None None None 9nw4 H L 0 P peptide NA pvcspvk210 peptide from circumsporozoite protein IMMUNE SYSTEM 03/25/26 Structure of CISV1 antibody bound to PvCSP repeat peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium vivax Hurlburt, N.K., Pancera, M. 1.82 X-RAY DIFFRACTION 0.215 0.183 False True IGHV3 IGKV4 Kappa None None None None None 9q6h B NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb33, nb77, nb125 & N42 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6h C NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb33, nb77, nb125 & N42 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6h D NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb33, nb77, nb125 & N42 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6h E NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb33, nb77, nb125 & N42 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6n B NA 0 A protein NA albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb118, nb68, N30 & N23 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6n C NA 0 A protein NA albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb118, nb68, N30 & N23 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6n D NA 0 A protein NA albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb118, nb68, N30 & N23 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6n E NA 0 A protein NA albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: nb118, nb68, N30 & N23 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6y B NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: N33, nb139 & nb104 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6y C NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: N33, nb139 & nb104 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6y E NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: N33, nb139 & nb104 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6z B NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: N33, nb139, nb39 & nb104 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6z C NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: N33, nb139, nb39 & nb104 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6z D NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: N33, nb139, nb39 & nb104 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q6z E NA 0 A protein NA serum albumin IMMUNE SYSTEM 03/25/26 Human Serum Albumin in complex with four nanobodies: N33, nb139, nb39 & nb104 Homo sapiens; Lama glama lama glama homo sapiens Hang, W., Sang, Z., Xiang, Y.F., Taylor, D.J., Shi, Y. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9t5z H L 0 B protein NA integrin beta-2 IMMUNE SYSTEM 03/25/26 Cryo-EM structure of alphaM/beta2:MEM148-Fab headpiece complex (without alphaM I-domain) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lorentzen, J., Andersen, G.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV14 Kappa None None None None None 9tmp H L 0 A protein NA soluble cytochrome b562 PROTEIN BINDING 03/25/26 Crystal Structure of Native Cytochrome b562 in complex with the synthetic anti-BRIL antibody BAG2. Escherichia coli BL21; synthetic construct synthetic construct synthetic construct escherichia coli bl21 Cooper, B.F., Isom, G.L. 2.65 X-RAY DIFFRACTION 0.238 0.207 False True IGHV3 IGKV1 Kappa None None None None None 9u5q B C 0 A | R protein | nucleic-acid NA | NA protease 3c | rna (83-mer) RNA BINDING PROTEIN/IMMUNE SYSTEM/RNA 03/25/26 HRV14 3C in complex with single chain antibody YDF and cloverleafRNA-conformation1 Homo sapiens; rhinovirus B14; SYNTHETIC CONSTRUCT homo sapiens homo sapiens rhinovirus b14 | rhinovirus b14 Yang, B., Wang, Q., Sun, S.W., Zhang, X. 3.35 ELECTRON MICROSCOPY NA NA True True IGHV3 IGLV3 Lambda None None None None None 9u5r P Q 0 O protein NA protease 3c RNA BINDING PROTEIN/IMMUNE SYSTEM/RNA 03/25/26 HRV14 3C in complex with single chain antibody YDF and cloverleafRNA-conformation 2 Homo sapiens; rhinovirus B14; SYNTHETIC CONSTRUCT homo sapiens homo sapiens rhinovirus b14 Yang, B., Wang, Q., Sun, S.W., Zhang, X. 3.59 ELECTRON MICROSCOPY NA NA True True IGHV3 IGLV3 Lambda None None None None None 9ulp C NA 0 A protein NA iron-hydroxamate abc transporter substrate-binding protein IMMUNE SYSTEM 03/25/26 Crystal structure of FtsB from Streptococcus pyogenes in complex with Nb1 nanobody Streptococcus pyogenes; Vicugna pacos vicugna pacos streptococcus pyogenes Fernandez-Perez, J., Caaveiro, J.M.M., Tsumoto, K. 2.55 X-RAY DIFFRACTION 0.307 0.253 False True IGHV1 NA NA None None None None None 9ulp D NA 0 B protein NA iron-hydroxamate abc transporter substrate-binding protein IMMUNE SYSTEM 03/25/26 Crystal structure of FtsB from Streptococcus pyogenes in complex with Nb1 nanobody Streptococcus pyogenes; Vicugna pacos vicugna pacos streptococcus pyogenes Fernandez-Perez, J., Caaveiro, J.M.M., Tsumoto, K. 2.55 X-RAY DIFFRACTION 0.307 0.253 False True IGHV1 NA NA None None None None None 9wb3 B C 0 A | R protein | nucleic-acid NA | NA protease 3c | rna (83-mer) RNA BINDING PROTEIN/RNA/IMMUNE SYSTEM 03/25/26 HRV14 3C in complex with single chain antibody YDF and cloverleafRNA-conformation1-composite-1 Homo sapiens; rhinovirus B14; SYNTHETIC CONSTRUCT homo sapiens homo sapiens rhinovirus b14 | rhinovirus b14 Wang, Q. 3.17 ELECTRON MICROSCOPY NA NA True True IGHV3 IGLV3 Lambda None None None None None 9wb4 B C 0 A | R protein | nucleic-acid NA | NA protease 3c | rna (83-mer) RNA BINDING PROTEIN/RNA/IMMUNE SYSTEM 03/25/26 HRV14 3C in complex with single chain antibody YDF and cloverleafRNA-conformation1-composite-2 Homo sapiens; rhinovirus B14; SYNTHETIC CONSTRUCT homo sapiens homo sapiens rhinovirus b14 | rhinovirus b14 Wang, Q. 3.32 ELECTRON MICROSCOPY NA NA True True IGHV3 IGLV3 Lambda None None None None None 10op G H 0 A protein NA envelope glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV5 Lambda None None None None None 10op I J 0 E protein NA envelope glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV5 Lambda None None None None None 10op K L 0 C protein NA envelope glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV5 Lambda None None None None None 10op M N 0 B protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 10op O P 0 F protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 10op Q R 0 D protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 10op S T 0 B protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 10op U V 0 F protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 10op W X 0 D protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 545S, 523S and 294S Homo sapiens; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 10or G H 0 A protein NA envelope glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus macaca mulatta macaca mulatta sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 10or I J 0 E protein NA envelope glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus macaca mulatta macaca mulatta sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 10or K L 0 C protein NA envelope glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus macaca mulatta macaca mulatta sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 10or M N 0 B protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 10or O P 0 F protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 10or Q R 0 D protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 10or S T 0 B protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 10or U V 0 F protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 10or W X 0 D protein NA envelope glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of Sudan Ebolavirus GP bound by three neutralizing antibodies 316L, 523S and 294S Homo sapiens; Macaca mulatta; Sudan ebolavirus homo sapiens homo sapiens sudan ebolavirus Cheng, J., Zhao, B., Misasi, J., Pierson, T.C., Sullivan, N.J., Zhou, T., Kwong, P.D. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vzw H L 0 NA NA NA NA IMMUNE SYSTEM 03/18/26 Structure of humanized MS-Hu6 Fab fragment Homo sapiens homo sapiens homo sapiens Misra, A., Schuermann, J., Gupta, Y.K., Yuen, T., Zaidi, M. 2.5 X-RAY DIFFRACTION 0.258 0.221 False True IGHV4 IGKV1 Kappa None None None None None 9d3j A B 0 C protein NA pfcsp_res5-y_mc2 scaffold IMMUNE SYSTEM 03/18/26 Structure of L9 Fab in complex with CSP_Res5-Y_mC2 Scaffold Homo sapiens; Plasmodium (Plasmodium) homo sapiens homo sapiens plasmodium (plasmodium) Jain, M., Agrawal, S., WIlson, I.A. 3.5 X-RAY DIFFRACTION 0.323 0.272 False True IGHV3 IGKV1 Kappa None None None None None 9d3j E F 0 D protein NA pfcsp_res5-y_mc2 scaffold IMMUNE SYSTEM 03/18/26 Structure of L9 Fab in complex with CSP_Res5-Y_mC2 Scaffold Homo sapiens; Plasmodium (Plasmodium) homo sapiens homo sapiens plasmodium (plasmodium) Jain, M., Agrawal, S., WIlson, I.A. 3.5 X-RAY DIFFRACTION 0.323 0.272 False True IGHV3 IGKV1 Kappa None None None None None 9kwy C B 0 G | A protein | protein NA | NA spike protein s1 | processed angiotensin-converting enzyme 2 VIRAL PROTEIN/HYDROLASE 03/18/26 Cryo-EM structure of SARS-CoV-2 RBD in complex with ACE2 and mAb 1C4 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 | homo sapiens Sun, H., Jiang, Y., Li, S., Zheng, Q. 2.82 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 9lz0 H L 0 A | R protein | protein NA | NA beta-arrestin-1 | parathyroid hormone/parathyroid hormone-related peptidereceptor MEMBRANE PROTEIN 03/18/26 Cryo-EM structure of PTH1R-beta-arrestin1 complex in state 1 Bos taurus; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Zhai, X., Guo, J., Shen, Q., Chen, L., Wang, G., Shen, D., Zhang, C., Xu, X., Mao, C., Zhang, Y., Liu, Z. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9m72 A B 0 C protein NA p15 VIRAL PROTEIN 03/18/26 ASFV p15 in complex with Fab 4E2 African swine fever virus (strain Badajoz 1971 Vero-adapted); Sus scrofa sus scrofa sus scrofa african swine fever virus (strain badajoz 1971vero-adapted) Wang, X., Yu, Q., Fu, W. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9m72 D F 0 H protein NA p15 VIRAL PROTEIN 03/18/26 ASFV p15 in complex with Fab 4E2 African swine fever virus (strain Badajoz 1971 Vero-adapted); Sus scrofa sus scrofa sus scrofa african swine fever virus (strain badajoz 1971vero-adapted) Wang, X., Yu, Q., Fu, W. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9m72 E G 0 I protein NA p15 VIRAL PROTEIN 03/18/26 ASFV p15 in complex with Fab 4E2 African swine fever virus (strain Badajoz 1971 Vero-adapted); Sus scrofa sus scrofa sus scrofa african swine fever virus (strain badajoz 1971vero-adapted) Wang, X., Yu, Q., Fu, W. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9m8k N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-3 MEMBRANE PROTEIN 03/18/26 cryo-EM structure of human TAS2R4 with oligopeptide Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Tan, M., Wu, J. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9m8l N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-3 MEMBRANE PROTEIN/IMMUNE SYSTEM 03/18/26 cryo-EM structure of human TAS2R4 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Tan, M., Wu, J. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ma0 B C 0 A protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of EBV gp350 D123 in complex with neutralizing antibody 4A11 Homo sapiens; Human herpesvirus 4 strain B95-8 homo sapiens homo sapiens human herpesvirus 4 strain b95-8 Ma, H.Y., Sun, C. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9ma7 B C 0 A protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of EBV gp350 D123 in complex with neutralizing antibody 1A12 and 1H5 and non-neutralizing antibody 2E9 Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Ma, H.Y., Sun, C. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9ma7 D E 0 A protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of EBV gp350 D123 in complex with neutralizing antibody 1A12 and 1H5 and non-neutralizing antibody 2E9 Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Ma, H.Y., Sun, C. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9ma7 F G 0 A protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of EBV gp350 D123 in complex with neutralizing antibody 1A12 and 1H5 and non-neutralizing antibody 2E9 Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Ma, H.Y., Sun, C. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9noa A B 0 NA NA NA NA IMMUNE SYSTEM 03/18/26 Crystal structure of unliganded Fab MS-1805 Homo sapiens homo sapiens homo sapiens Jain, M., Wilson, I.A. 1.77 X-RAY DIFFRACTION 0.231 0.204 False True IGHV3 IGKV1 Kappa None None None None None 9noa C D 0 NA NA NA NA IMMUNE SYSTEM 03/18/26 Crystal structure of unliganded Fab MS-1805 Homo sapiens homo sapiens homo sapiens Jain, M., Wilson, I.A. 1.77 X-RAY DIFFRACTION 0.231 0.204 False True IGHV3 IGKV1 Kappa None None None None None 9nob H L 0 NA NA NA NA IMMUNE SYSTEM 03/18/26 Crystal Structutre of unliganded Fab 224 Homo sapiens homo sapiens homo sapiens Jain, M., Wilson, I.A. 1.69 X-RAY DIFFRACTION 0.230 0.199 False True IGHV3 IGLV1 Lambda None None None None None 9rl5 P NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein | gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 03/18/26 a5b3 GABAAR bound to Topiramate, GABA, and Mb25 in a desensitized state in saposin nanodiscs Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens, aequorea victoria | homo sapiens, aequorea victoria Cowgirl, J., Lindahl, E., Howard, R.J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9rpb P NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein | gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 03/18/26 a5b3 GABAAR bound to GABA, and Mb25 in a desensitized state in saposin nanodiscs, topiramate-free Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens, aequorea victoria | homo sapiens, aequorea victoria Cowgill, J., Lindahl, E., Howard, R.J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9sat H L 0 R protein NA spike protein s1 VIRAL PROTEIN 03/18/26 Monoclonal Antibodies from COVID-19 Convalescent Patients Target Cryptic Epitopes for Universal SARS-CoV-2 Neutralization Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dessau, M., Harit, A. 2.56 X-RAY DIFFRACTION 0.275 0.231 False True IGHV1 IGKV3 Kappa None None None None None 9sbb H L 0 R protein NA spike protein s1 VIRAL PROTEIN 03/18/26 Monoclonal Antibodies from COVID-19 Convalescent Patients Target Cryptic Epitopes for Universal SARS-CoV-2 Neutralization Homo sapiens homo sapiens homo sapiens homo sapiens Dessau, M., Harit, A. 2.12 X-RAY DIFFRACTION 0.230 0.197 False True IGHV3 IGLV2 Lambda None None None None None 9uam E e 0 B | C protein | protein NA | NA minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 BINDING PROTEIN/IMMUNE SYSTEM 03/18/26 CysLTR2-LTC4-miniGq complex Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Wang, C., Liu, H. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9uan E e 0 B | C protein | protein NA | NA minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 LIPID BINDING PROTEIN/IMMUNE SYSTEM 03/18/26 CysLTR2-LTD4-miniGq complex Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Wang, C., Liu, H. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9vmn S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of the a-KG-OXGR1-Gq complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Tang, X.J., Sun, J.P., Guo, L.L., Li, J., Deng, Z.L., Xiao, W.Q., Zhu, Y., Zhu, K.K. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9vmo S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of the ITA-OXGR1-Gq complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Tang, X.J., Sun, J.P., Guo, L.L., Li, J., Deng, Z.L., Xiao, W.Q., Zhu, Y., Zhu, K.K. 2.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9vo2 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 03/18/26 Cryo-EM structure of the OXGR1(CA)-Gq complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Tang, X.J., Sun, J.P., Guo, L.L., Li, J., Deng, Z.L., Xiao, W.Q., Zhu, Y., Zhu, K.K. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9w14 C B 0 G protein NA spike protein s1 VIRAL PROTEIN 03/18/26 Cryo-EM structure of SARS-CoV-2 WT spike protein in complex with nAb 1C4 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 2.33 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 9wwh H L 0 D protein NA interleukin-33 (109-270) CYTOKINE/IMMUNE SYSTEM 03/18/26 Crystal structure of IL-33 and antibody Tozorakimab fab binary complex Homo sapiens homo sapiens homo sapiens homo sapiens Wang, X.Q., Chen, J., Wang, Y. 3.51 X-RAY DIFFRACTION 0.259 0.230 False True IGHV3 IGLV3 Lambda None None None None None 9wwh A B 0 C protein NA interleukin-33 (109-270) CYTOKINE/IMMUNE SYSTEM 03/18/26 Crystal structure of IL-33 and antibody Tozorakimab fab binary complex Homo sapiens homo sapiens homo sapiens homo sapiens Wang, X.Q., Chen, J., Wang, Y. 3.51 X-RAY DIFFRACTION 0.259 0.230 False True IGHV3 IGLV3 Lambda None None None None None 9x05 B E 0 A protein NA interleukin-33 (109-270) CYTOKINE/IMMUNE SYSTEM 03/18/26 IL-33 and Itepekimab fab and Tozorakimab fab ternary complex structure Homo sapiens homo sapiens homo sapiens homo sapiens Wang, X.Q., Wang, Y. 3.64 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9x05 D C 0 A protein NA interleukin-33 (109-270) CYTOKINE/IMMUNE SYSTEM 03/18/26 IL-33 and Itepekimab fab and Tozorakimab fab ternary complex structure Homo sapiens homo sapiens homo sapiens homo sapiens Wang, X.Q., Wang, Y. 3.64 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9x0j F C 0 A protein NA interleukin-33 (109-270) CYTOKINE/IMMUNE SYSTEM 03/18/26 IL-33 and Etokimab fab and Tozorakimab fab ternary complex structure Homo sapiens homo sapiens homo sapiens homo sapiens Wang, X.Q., Wang, Y. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9x0j E B 0 A protein NA interleukin-33 (109-270) CYTOKINE/IMMUNE SYSTEM 03/18/26 IL-33 and Etokimab fab and Tozorakimab fab ternary complex structure Homo sapiens homo sapiens homo sapiens homo sapiens Wang, X.Q., Wang, Y. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ynr D E 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 03/18/26 Local refinement of Fab-14/SARS-CoV-2 D614G spike complex, Mode I Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9ynx D E 0 B protein NA spike protein s1 VIRAL PROTEIN 03/18/26 Local refinement of Fab-14/SARS-CoV-2 D614G spike complex, Mode I, Subgroup I conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9ynx F G 0 A protein NA spike protein s1 VIRAL PROTEIN 03/18/26 Local refinement of Fab-14/SARS-CoV-2 D614G spike complex, Mode I, Subgroup I conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9yok D E 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 03/18/26 Fab-14/SARS-CoV-2 D614G spike complex, Mode I conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 3.56 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9ypb D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/18/26 Fab-14/SARS-CoV-2 D614G spike complex, Mode IV, subgroup II conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9ypb F G 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/18/26 Fab-14/SARS-CoV-2 D614G spike complex, Mode IV, subgroup II conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9ypr D E 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/18/26 Fab-14/SARS-CoV-2 D614G spike complex, Mode IV, subgroup II conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9ypr G F 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/18/26 Fab-14/SARS-CoV-2 D614G spike complex, Mode IV, subgroup II conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Hu, Y., Leiman, P., Xie, X. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9nj3 H L 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibodies #46 and #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9nj3 J K 0 C | B protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibodies #46 and #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus | influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9nj3 Q P 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibodies #46 and #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 9nj9 H L 0 A | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibodies #46 and #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus | influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9nj9 Q P 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibodies #46 and #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 9nj9 J K 0 B protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibodies #46 and #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 9yxd D C 0 A | B protein | protein NA | NA glycoprotein hormones alpha chain | follitropin subunit beta HORMONE 03/11/26 Crystal structure of recombinant human follicle stimulating hormone in complex with an anti-FSH alpha Fab Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Joseph, J.S., Kalson, D., Bakshi, S. 2.29 X-RAY DIFFRACTION 0.235 0.201 False True IGHV1 IGKV3 Kappa None None None None None 9yxd K NA 0 NA NA NA NA HORMONE 03/11/26 Crystal structure of recombinant human follicle stimulating hormone in complex with an anti-FSH alpha Fab Homo sapiens; Lama glama; Mus musculus lama glama Joseph, J.S., Kalson, D., Bakshi, S. 2.29 X-RAY DIFFRACTION 0.235 0.201 False True IGHV1 NA NA None None None None None 9lz1 H L 0 A | R protein | protein NA | NA beta-arrestin-1 | parathyroid hormone/parathyroid hormone-related peptidereceptor MEMBRANE PROTEIN 03/11/26 Cryo-EM structure of PTH1R-beta-arrestin1 complex in state 2 Bos taurus; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Zhai, X., Guo, J., Shen, Q., Chen, L., Wang, G., Shen, D., Zhang, C., Xu, X., Mao, C., Zhang, Y., Liu, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9lz2 H L 0 A | R protein | protein NA | NA beta-arrestin-1 | parathyroid hormone/parathyroid hormone-related peptidereceptor,vasopressin v2 receptor MEMBRANE PROTEIN 03/11/26 Cryo-EM structure of PTH1R(V2RC)-beta-arrestin1 complex Bos taurus; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Zhai, X., Guo, J., Shen, Q., Chen, L., Wang, G., Shen, D., Zhang, C., Xu, X., Mao, C., Zhang, Y., Liu, Z. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9m3q N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/11/26 Cryo-EM structure of the spermidine-bound zTAAR13c-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.74 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m3s N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/11/26 Cryo-EM structure of the histamine-bound zTAAR13a-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m40 N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/11/26 Cryo-EM structure of the agmatine-bound zTAAR13e-Gs complex Danio rerio; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ncy H L 0 A protein NA circumsporozoite protein IMMUNE SYSTEM 03/11/26 Fab1392 in complex with the C-terminal alpha-TSR domain of the P. falciparum circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Moskovitz, R., Wilson, I.A. 1.63 X-RAY DIFFRACTION 0.194 0.174 False True IGHV4 IGKV1 Kappa None None None None None 9nj2 H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 03/11/26 N1 neuraminidase of influenza A/Vietnam/1203/2004 H5N1 in complex with four FNI9 Fab molecules Homo sapiens; Influenza A virus (A/Viet Nam/1203/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) Errico, J.M., Dang, H.V., Snell, G. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nj2 I M 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 03/11/26 N1 neuraminidase of influenza A/Vietnam/1203/2004 H5N1 in complex with four FNI9 Fab molecules Homo sapiens; Influenza A virus (A/Viet Nam/1203/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) Errico, J.M., Dang, H.V., Snell, G. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nj2 J N 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 03/11/26 N1 neuraminidase of influenza A/Vietnam/1203/2004 H5N1 in complex with four FNI9 Fab molecules Homo sapiens; Influenza A virus (A/Viet Nam/1203/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) Errico, J.M., Dang, H.V., Snell, G. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nj2 K O 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 03/11/26 N1 neuraminidase of influenza A/Vietnam/1203/2004 H5N1 in complex with four FNI9 Fab molecules Homo sapiens; Influenza A virus (A/Viet Nam/1203/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) Errico, J.M., Dang, H.V., Snell, G. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nj6 H L 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibody #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9nj6 J K 0 B protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibody #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9nj6 Q P 0 C protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibody #3978 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9nja H L 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibody #46 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 9nja J K 0 B protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibody #46 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 9nja Q P 0 C protein NA hemagglutinin VIRAL PROTEIN/Immune System 03/11/26 Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibody #46 Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dzimianski, J.V., Kunkel, I., Balasco Serrao, V.H., DuBois, R.M. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 9t3r H L 0 A protein NA receptor tyrosine-protein kinase erbb-2 ANTITUMOR PROTEIN 03/11/26 Structure of human HER2 in complex with EPS232 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Birtley, J., Johnson, R.M., Regan, L., Soni, K., Pye, V.E., Fitzgerald, K. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9t3s H L 0 A protein NA receptor tyrosine-protein kinase erbb-2 ANTITUMOR PROTEIN 03/11/26 Structure of human HER2 in complex with EPS226 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Birtley, J., Regan, L., Johnson, R.M., Soni, K., Pye, V.E., Fitzgerald, K. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9zt7 A B 0 C protein NA spike protein s2 VIRAL PROTEIN/Immune System 03/11/26 SARS-CoV-2 S2 in complex with COV2-2509 Homo sapiens homo sapiens homo sapiens homo sapiens Park, S., Ward, A.B. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9pit H L 0 B protein NA envelope glycoprotein gp160 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9pit J G 0 B | D protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp41 - bg505 md39 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9pit M Q 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9pit O I 0 E | A protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp41 - bg505 md39 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9pit N R 0 F protein NA envelope glycoprotein gp160 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9pit P K 0 F | C protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp41 - bg505 md39 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9piv J G 0 B | D protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp41 - bg505 md39 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9piv H L 0 B protein NA envelope glycoprotein gp160 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9piv O I 0 E | A protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp41 - bg505 md39 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9piv M Q 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9piv P K 0 F | C protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp41 - bg505 md39 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9piv N R 0 F protein NA envelope glycoprotein gp160 VIRAL PROTEIN 03/04/26 HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Ozorowski, G., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9zen L NA 0 D | C protein | protein NA | NA histone h2b type 1-k | histone h2a type 1-b/e DE NOVO PROTEIN 03/04/26 Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1B2 artificial sequences; Homo sapiens artificial sequences homo sapiens | homo sapiens Chakraborty, U., Saccone, E.C., Becerra, G.C., Khan, L.F., Arslanovic, N., Aguilar, R., Gloor, S.L., Hunt, S.R., Folkwein, H.J., Husby, N.L., Maier, K.E., Marunde, M.R., Schomburg, N.K., Vaidya, A., Cowles, M.W., Venters, B.J., Kassavetis, G., Sun, Z.-W., Kadonaga, J.T., Armache, J.-P., Keogh, M.-C., Tyler, J.K. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9zen K NA 0 H | G protein | protein NA | NA histone h2b type 1-k | histone h2a type 1-b/e DE NOVO PROTEIN 03/04/26 Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1B2 artificial sequences; Homo sapiens artificial sequences homo sapiens | homo sapiens Chakraborty, U., Saccone, E.C., Becerra, G.C., Khan, L.F., Arslanovic, N., Aguilar, R., Gloor, S.L., Hunt, S.R., Folkwein, H.J., Husby, N.L., Maier, K.E., Marunde, M.R., Schomburg, N.K., Vaidya, A., Cowles, M.W., Venters, B.J., Kassavetis, G., Sun, Z.-W., Kadonaga, J.T., Armache, J.-P., Keogh, M.-C., Tyler, J.K. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9gfr H L 0 G | F | E protein | protein | protein NA | NA | NA recombinant collagen triple helical peptide (thp59)covalently linked to foldon trimerization domain | recombinant collagen triple helical peptide (thp59)covalently linked to foldon trimerization domain | recombinant collagen triple helical peptide (thp59)covalently linked to foldon trimerization domain IMMUNE SYSTEM 03/04/26 Crystal structure of anti-collagen type II antibody Fab (PC12) complexed with collagen triple helical peptide (THP59) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Ge, C., Dobritzsch, D., Holmdahl, R. 2.06 X-RAY DIFFRACTION 0.247 0.204 False False IGHV1 IGKV6 Kappa None None None None None 9iar C NA 0 A protein NA sodium-independent sulfate anion transporter MEMBRANE PROTEIN 03/04/26 Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb11 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Rasmussen, T., Kuhn, B.T., Bottcher, B., Geertsma, E.R. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9iar D NA 0 B protein NA sodium-independent sulfate anion transporter MEMBRANE PROTEIN 03/04/26 Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb11 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Rasmussen, T., Kuhn, B.T., Bottcher, B., Geertsma, E.R. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ias C NA 0 B protein NA sodium-independent sulfate anion transporter MEMBRANE PROTEIN 03/04/26 Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb4 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Rasmussen, T., Kuhn, B.T., Bottcher, B., Geertsma, E.R. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ias D NA 0 A protein NA sodium-independent sulfate anion transporter MEMBRANE PROTEIN 03/04/26 Sulfate transporter SLC26A11 in nanodiscs with nanobody Nb4 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Rasmussen, T., Kuhn, B.T., Bottcher, B., Geertsma, E.R. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ib1 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/04/26 Cryo-EM focus map of prefusion SARS-CoV-2 spike (RBDs: 1 up & 2 down) bound to RBD-targeting MO176-117 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Schulte, T., Wallden, W., Andrell, J., Ohlin, M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ib3 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/04/26 Cryo-EM focus map of prefusion SARS-CoV-2 spike (RBDs: 2 up & 1 down) bound to RBD-targeting MO176-117 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Schulte, T., Wallden, W., Andrell, J., Ohlin, M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9j93 C c 0 A protein NA glutamate receptor MEMBRANE PROTEIN 03/04/26 Native GluA1/GluA4 ATD dimer binding with 1D8 and 11B8 Mus musculus; Sus scrofa mus musculus sus scrofa Li, X., Li, R., Wei, Y., Zhao, Y. 3.54 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lle N NA 0 D | B | C protein | protein | protein NA | NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 03/04/26 Cryo-EM structure of D1R-Gs in complex with de novo designed GEM targeting TM1/2/4 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Guo, J., Zhou, Y., Cheng, S., Zhang, Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9llf N NA 0 A | C | B protein | protein | protein NA | NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/04/26 Cryo-EM structure of D1R-Gs in complex with de novo designed GEM targeting TM3/4/5 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Guo, J., Zhou, Y., Cheng, S., Zhang, Y. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9llh N NA 0 A | C | B protein | protein | protein NA | NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/04/26 Cryo-EM structure of D1R-Gs in complex with de novo designed agonist-positive allosteric GEM targeting TM5/6/7 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Guo, J., Zhou, Y., Cheng, S., Zhang, Y. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9llj N NA 0 A | C | B protein | protein | protein NA | NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/04/26 Cryo-EM structure of D1R-Gs in complex with de novo designed GEM targetingTM1/2/4 and GEM targeting TM3/4/5, and agonist-positive allosteric GEM targeting TM5/6/7 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Guo, J., Zhou, Y., Cheng, S., Zhang, Y. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9lxp C E 0 B | R protein | protein NA | NA beta-arrestin-1 | parathyroid hormone/parathyroid hormone-related peptidereceptor MEMBRANE PROTEIN 03/04/26 A Cryo-EM structure of LA-PTH-PTH1R-B-arrestin1 complex (state 2 conformation) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Zhao, L., Yuan, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ly2 C E 0 B | R protein | protein NA | NA beta-arrestin-1 | parathyroid hormone/parathyroid hormone-related peptidereceptor,vasopressin v2 receptor MEMBRANE PROTEIN 03/04/26 A Cryo-EM structure of LA-PTH-PTH1R-V2RT-Beta-arrestin1 complex (state 1 conformation) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Zhao, L., Yuan, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ly3 C E 0 B | R protein | protein NA | NA beta-arrestin-1 | parathyroid hormone/parathyroid hormone-related peptidereceptor,vasopressin v2 receptor MEMBRANE PROTEIN 03/04/26 A Cryo-EM structure of LA-PTH-PTH1R-V2R-Beta-arrestin1 complex (state 2 conformation) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Zhao, L., Yuan, Q. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ly5 A B 0 C protein NA cd276 antigen ANTITUMOR PROTEIN/IMMUNE SYSTEM 03/04/26 antibody 20G5 Fab in complex with human B7-H3 (IgC) Homo sapiens homo sapiens homo sapiens homo sapiens Bin, L., Shuaixiang, Z., kaijie, H. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ly6 B C 0 A protein NA cd276 antigen ANTITUMOR PROTEIN/IMMUNE SYSTEM 03/04/26 antibody 20G5 (Fab')2 in complex with human B7-H3 Homo sapiens homo sapiens homo sapiens homo sapiens Li, B., Zhou, S., He, K. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ly6 D E 0 A protein NA cd276 antigen ANTITUMOR PROTEIN/IMMUNE SYSTEM 03/04/26 antibody 20G5 (Fab')2 in complex with human B7-H3 Homo sapiens homo sapiens homo sapiens homo sapiens Li, B., Zhou, S., He, K. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9m0j N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 03/04/26 Cryo-EM structure of Bombesin receptor type-3 bound to oridonin Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Li, C., Xu, Y., Yin, W., Xu, H. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m0x N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/04/26 Cryo-EM structure of the agmatine-bound zTAAR13d-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m0z N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/04/26 Cryo-EM structure of the cadaverine-bound zTAAR13d-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.74 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m1p N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/04/26 Cryo-EM structure of the histamine-bound zTAAR13d-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m2o N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/04/26 Cryo-EM structure of the putrescine-bound zTAAR13d-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.59 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m2s N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/04/26 Cryo-EM structure of the cadaverine-bound zTAAR13c-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zheng, Y., Zhao, S.W. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9nky H L 0 NA NA NA NA IMMUNE SYSTEM 03/04/26 Crystal structure of unliganded Fab MAM01 Homo sapiens homo sapiens homo sapiens Jain, M., Wilson, I.A. 2.08 X-RAY DIFFRACTION 0.279 0.233 False True IGHV3 IGLV1 Lambda None None None None None 9nkz H L 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 03/04/26 Crystal structure of Fab MAM01 in complex with NANP6 peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 1.48 X-RAY DIFFRACTION 0.210 0.191 False True IGHV3 IGLV1 Lambda None None None None None 9nl0 H L 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 03/04/26 Crystal structure of Fab MAM01 in complex with NPNA3 peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 1.54 X-RAY DIFFRACTION 0.202 0.176 False True IGHV3 IGLV1 Lambda None None None None None 9nl1 H L 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 03/04/26 Crystal structure of Fab MAM01 in complex with junctional region peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 2.71 X-RAY DIFFRACTION 0.313 0.255 False True IGHV3 IGLV1 Lambda None None None None None 9owe C D 0 B protein NA genome polyprotein IMMUNE SYSTEM 03/04/26 CryoEM structure of stabilized dengue 3 virus envelope glycoprotein in complex with Fab of F25.S02 dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 Hurlburt, N.K., Pancera, M. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9owe H L 0 A protein NA genome polyprotein IMMUNE SYSTEM 03/04/26 CryoEM structure of stabilized dengue 3 virus envelope glycoprotein in complex with Fab of F25.S02 dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 Hurlburt, N.K., Pancera, M. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9owf C D 0 B protein NA genome polyprotein IMMUNE SYSTEM 03/04/26 X-ray crystal structure of Zika virus envelope glycoprotein in complex with Fab of F25.S02 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Hurlburt, N.K., Pancera, M. 2.3 X-RAY DIFFRACTION 0.274 0.225 False True IGHV1 IGLV2 Lambda None None None None None 9owf H L 0 A protein NA genome polyprotein IMMUNE SYSTEM 03/04/26 X-ray crystal structure of Zika virus envelope glycoprotein in complex with Fab of F25.S02 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Hurlburt, N.K., Pancera, M. 2.3 X-RAY DIFFRACTION 0.274 0.225 False True IGHV1 IGLV2 Lambda None None None None None 9ppw E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/04/26 CryoEM structure of delta opioid receptor bound to G proteins and Naltrindole Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Fay, J.F., Che, T. 3.32 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ppy E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/04/26 CryoEM structure of delta opioid receptor bound to G proteins and met-enkephalin Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Fay, J.F., Che, T. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9wai E F 0 D | B protein | protein NA | NA capsid protein vp1 | capsid protein vp2 VIRUS LIKE PARTICLE/IMMUNE SYSTEM 03/04/26 Yeast-expressed polio type 1 stablized virus-like particles with 3G10 Fab Mus musculus; Poliovirus 1 mus musculus mus musculus poliovirus 1 | poliovirus 1 Hong, Q., Cong, Y. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV6 Kappa None None None None None 9zeo K NA 0 H | G protein | protein NA | NA histone h2b type 1-k | histone h2a type 1-b/e DE NOVO PROTEIN 03/04/26 Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1G1 artificial sequences; Homo sapiens homo sapiens homo sapiens | homo sapiens Chakraborty, U., Saccone, E.C., Becerra, G.C., Khan, L.F., Arslanovic, N., Aguilar, R., Gloor, S.L., Hunt, S.R., Folkwein, H.J., Husby, N.L., Maier, K.E., Marunde, M.R., Schomburg, N.K., Vaidya, A., Cowles, M.W., Venters, B.J., Kassavetis, G., Sun, Z.-W., Kadonaga, J.T., Armache, J.-P., Keogh, M.-C., Tyler, J.K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 10gh C B 0 A protein NA proto-oncogene tyrosine-protein kinase ros TRANSFERASE/IMMUNE SYSTEM 02/25/26 Cryo-EM structure of Receptor Tyrosine Kinase ROS1 in complex with Fab-RX5 Homo sapiens; Mus musculus homo sapiens homo sapiens mus musculus Li, H., Klein, D. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dz4 C B 0 A protein NA proto-oncogene tyrosine-protein kinase ros TRANSFERASE/IMMUNE SYSTEM 02/25/26 Cryo-EM Structure of Receptor Tyrosine Kinase ROS1 in Complex with Fab-CT4 Homo sapiens; Mus musculus homo sapiens homo sapiens mus musculus Li, H., Klein, D. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9i5n B A 0 C protein NA cd40 ligand, soluble form IMMUNE SYSTEM 02/25/26 Single particle cryo electron microscopy of a Fab fragment bound to recombinant human CD40 ligand Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kristoffersen, E.L., Schinkel, T., Andersen, E.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV17 Kappa None None None None None 9j87 E e 0 B | C protein | protein NA | NA g protein subunit q (gi2-mini-gq chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/25/26 Structure of Receptor Homo sapiens homo sapiens homo sapiens | homo sapiens Min, H., Kim, K. 2.84 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9nvg H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Structure of SARS-CoV-2 BA.1 spike RBD bound to COV2-3835 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ramamohan, A.R., Johnson, N.V., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 9psn J K 0 E protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-105 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.54 X-RAY DIFFRACTION 0.254 0.202 False True IGHV3 IGKV3 Kappa None None None None None 9psn M N 0 T protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-105 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.54 X-RAY DIFFRACTION 0.254 0.202 False True IGHV3 IGKV3 Kappa None None None None None 9psn O P 0 E protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-105 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.54 X-RAY DIFFRACTION 0.254 0.202 False True IGHV5 IGKV8 Kappa None None None None None 9psn Q R 0 T protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-105 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.54 X-RAY DIFFRACTION 0.254 0.202 False True IGHV5 IGKV8 Kappa None None None None None 9pso F G 0 E protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-622 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.62 X-RAY DIFFRACTION 0.258 0.206 False True IGHV3 IGKV3 Kappa None None None None None 9pso H L 0 E protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-622 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.62 X-RAY DIFFRACTION 0.258 0.206 False True IGHV5 IGKV8 Kappa None None None None None 9psp K W 0 T protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-1173 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.247 0.195 False True IGHV3 IGKV3 Kappa None None None None None 9psp M N 0 U protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-1173 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.247 0.195 False True IGHV3 IGKV3 Kappa None None None None None 9psp H L 0 T protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-1173 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.247 0.195 False True IGHV5 IGKV8 Kappa None None None None None 9psp A B 0 U protein NA spike protein s1 receptor binding domain VIRAL PROTEIN/IMMUNE SYSTEM 02/25/26 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies BoWLB-1173 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.247 0.195 False True IGHV5 IGKV8 Kappa None None None None None 9wey N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, hibit fusion MEMBRANE PROTEIN 02/25/26 Structure of HCMV UL33 in complex with human Gs protein Homo sapiens; Human betaherpesvirus 5; Lama glama lama glama homo sapiens | homo sapiens Tsutsumi, N., Suzuki, S., Nishikawa, K., Fujiyoshi, Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9j5l C B 0 2 protein NA designed influenza hemagglutinin stem #219 ha2 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 Complex structure of influenza hemagglutinin HA stem with CR9114 Fab and FISW84 Fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Ru, Y.X., Liu, D.J., Deng, L., Li, Y.W. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9j5l E D 0 2 | 1 protein | peptide NA | NA designed influenza hemagglutinin stem #219 ha2 | designed influenza hemagglutinin stem #219 ha1 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 Complex structure of influenza hemagglutinin HA stem with CR9114 Fab and FISW84 Fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct | synthetic construct Ru, Y.X., Liu, D.J., Deng, L., Li, Y.W. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9lsy E C 0 D protein NA tra@ protein IMMUNE SYSTEM 02/18/26 Structure of the gdTCR-Fab complex Homo sapiens homo sapiens homo sapiens homo sapiens Bai, Y., Zhu, Y., Huang, Z. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV10 Kappa None None None None None 9lsy H F 0 A protein NA tra@ protein IMMUNE SYSTEM 02/18/26 Structure of the gdTCR-Fab complex Homo sapiens homo sapiens homo sapiens homo sapiens Bai, Y., Zhu, Y., Huang, Z. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV10 Kappa None None None None None 9lw5 S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 02/18/26 Cryo-EM structure of dopamine bound mut-beta2-Adrenergic Receptor beta2R-M16-miniGs-Gbeta1gamma2-Nb35-scFv16 complex Homo sapiens; Vicugna pacos homo sapiens homo sapiens Zhang, X., Gao, K., Liu, X. 2.87 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lw5 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/18/26 Cryo-EM structure of dopamine bound mut-beta2-Adrenergic Receptor beta2R-M16-miniGs-Gbeta1gamma2-Nb35-scFv16 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Zhang, X., Gao, K., Liu, X. 2.87 ELECTRON MICROSCOPY NA NA True True IGHV3 NA NA None None None None None 9n7q H L 0 a | A protein | protein NA | NA unknown | h1 ha2 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H1 hemagglutinin (A/Michigan/45/2015) in complex with anchor-targeting Fab ST15 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9n7q E G 0 b | B protein | protein NA | NA unknown | h1 ha2 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H1 hemagglutinin (A/Michigan/45/2015) in complex with anchor-targeting Fab ST15 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9n7q D F 0 c | C protein | protein NA | NA unknown | h1 ha2 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H1 hemagglutinin (A/Michigan/45/2015) in complex with anchor-targeting Fab ST15 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9n7t H L 0 a | A protein | protein NA | NA unknown | h5 ha2 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H5 hemagglutinin (A/Jiangsu/NJ210/2023) in complex with central stem-targeting Fab ST14 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9n7t D F 0 I | B protein | protein NA | NA h5 ha2 | h5 ha1 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H5 hemagglutinin (A/Jiangsu/NJ210/2023) in complex with central stem-targeting Fab ST14 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9n7t E G 0 J | C protein | protein NA | NA h5 ha2 | h5 ha1 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H5 hemagglutinin (A/Jiangsu/NJ210/2023) in complex with central stem-targeting Fab ST14 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9n8f H L 0 D | A protein | protein NA | NA sudv gulu - gp2 | sudv gulu - gp1 VIRAL PROTEIN 02/18/26 Cryo-EM structure of SUDV glycoprotein with modified HR1c (L579P) and HR2 stalk bound to CA45 Fab Homo sapiens; Sudan ebolavirus (strain Human/Uganda/Gulu/2000) homo sapiens homo sapiens sudan ebolavirus (strainhuman/uganda/gulu/2000) | sudan ebolavirus (strainhuman/uganda/gulu/2000) Lee, Y.Z., Ward, A.B., Zhu, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9n8f I M 0 E | B protein | protein NA | NA sudv gulu - gp2 | sudv gulu - gp1 VIRAL PROTEIN 02/18/26 Cryo-EM structure of SUDV glycoprotein with modified HR1c (L579P) and HR2 stalk bound to CA45 Fab Homo sapiens; Sudan ebolavirus (strain Human/Uganda/Gulu/2000) homo sapiens homo sapiens sudan ebolavirus (strainhuman/uganda/gulu/2000) | sudan ebolavirus (strainhuman/uganda/gulu/2000) Lee, Y.Z., Ward, A.B., Zhu, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9n8f J N 0 F | C protein | protein NA | NA sudv gulu - gp2 | sudv gulu - gp1 VIRAL PROTEIN 02/18/26 Cryo-EM structure of SUDV glycoprotein with modified HR1c (L579P) and HR2 stalk bound to CA45 Fab Homo sapiens; Sudan ebolavirus (strain Human/Uganda/Gulu/2000) homo sapiens homo sapiens sudan ebolavirus (strainhuman/uganda/gulu/2000) | sudan ebolavirus (strainhuman/uganda/gulu/2000) Lee, Y.Z., Ward, A.B., Zhu, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9zz6 K NA 0 H | C | E | B protein | protein | protein | protein NA | NA | NA | NA er membrane protein complex subunit 8 | er membrane protein complex subunit 3 | membrane magnesium transporter 1 | er membrane protein complex subunit 2 CHAPERONE/IMMUNE SYSTEM 02/18/26 The ER membrane protein complex acts as a chaperone to promote voltage-gated calcium channel assembly Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens | homo sapiens Singal, B., Biswal, M., Pleiner, T. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9zz6 L NA 0 A protein NA er membrane protein complex subunit 1 CHAPERONE/IMMUNE SYSTEM 02/18/26 The ER membrane protein complex acts as a chaperone to promote voltage-gated calcium channel assembly Homo sapiens; Lama glama lama glama homo sapiens Singal, B., Biswal, M., Pleiner, T. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9i6q H L 0 NA NA NA NA IMMUNE SYSTEM 02/18/26 Structure of Fab-Fragment GB11 agains tumour associated carbohydrate antigens. Mus musculus mus musculus mus musculus Freitag, A., Khilji, S.K., Nedielkov, R., Kumar, S.M., Krummhaar, M., Luehle, J., Goerdeler, F., Arndt, J., Kamphues, C., Mroginski, M.A., Roth, C., Seeberger, P.H., Moeller, H.M., Moscovitz, O. 1.86 X-RAY DIFFRACTION 0.239 0.200 False False IGHV6 IGKV14 Kappa None None None None None 9i9h A B 0 T carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/18/26 Structure of FAB-fragment GB11 in complex with Sialyl Lewis A Mus musculus mus musculus mus musculus Freitag, A., Khan-Kilji, S., Nedielkov, R., Murali Kumar, S., Krummhaar, M., Luehle, J., Goerdeler, F., Arndt, J., Kamphues, C., Mroginski, M.A., Roth, C., Seeberger, P.H., Moeller, H.M., Moscovitz, O. 2.96 X-RAY DIFFRACTION 0.248 0.210 False False IGHV6 IGKV14 Kappa None None None None None 9i9h H L 0 S carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/18/26 Structure of FAB-fragment GB11 in complex with Sialyl Lewis A Mus musculus mus musculus mus musculus Freitag, A., Khan-Kilji, S., Nedielkov, R., Murali Kumar, S., Krummhaar, M., Luehle, J., Goerdeler, F., Arndt, J., Kamphues, C., Mroginski, M.A., Roth, C., Seeberger, P.H., Moeller, H.M., Moscovitz, O. 2.96 X-RAY DIFFRACTION 0.248 0.210 False False IGHV6 IGKV14 Kappa None None None None None 9i9h C D 0 U carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/18/26 Structure of FAB-fragment GB11 in complex with Sialyl Lewis A Mus musculus mus musculus mus musculus Freitag, A., Khan-Kilji, S., Nedielkov, R., Murali Kumar, S., Krummhaar, M., Luehle, J., Goerdeler, F., Arndt, J., Kamphues, C., Mroginski, M.A., Roth, C., Seeberger, P.H., Moeller, H.M., Moscovitz, O. 2.96 X-RAY DIFFRACTION 0.248 0.210 False False IGHV6 IGKV14 Kappa None None None None None 9i9h E F 0 V carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/18/26 Structure of FAB-fragment GB11 in complex with Sialyl Lewis A Mus musculus mus musculus mus musculus Freitag, A., Khan-Kilji, S., Nedielkov, R., Murali Kumar, S., Krummhaar, M., Luehle, J., Goerdeler, F., Arndt, J., Kamphues, C., Mroginski, M.A., Roth, C., Seeberger, P.H., Moeller, H.M., Moscovitz, O. 2.96 X-RAY DIFFRACTION 0.248 0.210 False False IGHV6 IGKV14 Kappa None None None None None 9jno D B 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 The complex structure of antibody CH76 bound to the hemagglutinin of influenza B virus Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Ge, J.W., Fan, M., Zhao, M. 1.95 X-RAY DIFFRACTION 0.278 0.226 False True IGHV1 IGKV1 Kappa None None None None None 9l1l C D 0 P | B | A peptide | protein | protein NA | NA | NA lysozyme c | h-2 class ii histocompatibility antigen, a-k beta chain | h-2 class ii histocompatibility antigen, a-k alpha chain PROTEIN BINDING 02/18/26 Structure of anti-HEL AiTab Gallus gallus; Mus musculus mus musculus mus musculus gallus gallus | mus musculus | mus musculus Kawakami, K., Yonekura, K. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 9l8z C B 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 The complex structure of antibody CF22 bound to the hemagglutinin of influenza B virus Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Ge, J.W., Fan, M., Zhao, M. 3.448 X-RAY DIFFRACTION unknown 0.262 False True IGHV4 IGLV3 Lambda None None None None None 9l8z F E 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 The complex structure of antibody CF22 bound to the hemagglutinin of influenza B virus Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Ge, J.W., Fan, M., Zhao, M. 3.448 X-RAY DIFFRACTION unknown 0.262 False True IGHV4 IGLV3 Lambda None None None None None 9l9o B C 0 A protein NA melatonin-related receptor,soluble cytochrome b562 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/18/26 Cryo-EM structure of apo GPR50 with BRIL fusion, anti-BRIL Fab, and anti-Fab Nb complex Escherichia coli; Homo sapiens; synthetic construct homo sapiens homo sapiens homo sapiens, escherichia coli Shin, J., Cho, Y. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9l9o D NA 0 NA NA NA NA MEMBRANE PROTEIN/IMMUNE SYSTEM 02/18/26 Cryo-EM structure of apo GPR50 with BRIL fusion, anti-BRIL Fab, and anti-Fab Nb complex Escherichia coli; Homo sapiens; synthetic construct synthetic construct Shin, J., Cho, Y. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lsz H L 0 A protein NA sodium-dependent neutral amino acid transporter b(0)at1 TRANSPORT PROTEIN 02/18/26 Inward-open Structure of human B0AT1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Imazu, T., Miyaguchi, I., Hiraizumi, M. 3.11 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 9lwc N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/18/26 Cryo-EM structure of epinephrine bound dopamine receptor 1 D1R-M74-miniGs-Gbeta1gamma2-Nb35 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Zhang, X., Gao, K., Liu, X. 2.9 ELECTRON MICROSCOPY NA NA True True IGHV3 NA NA None None None None None 9n7s H L 0 a | B | A protein | protein | protein NA | NA | NA unknown | h1 ha1 | h1 ha1 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H1 hemagglutinin (A/California/04/2009) with E47K mutation in HA2 in complex with central stem-targeting Fab ST10 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV4 Kappa None None None None None 9n7v H L 0 a | A protein | protein NA | NA unknown | h1 ha2 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 H1 hemagglutinin (A/Michigan/45/2015) in complex with anchor-targeting Fab ST4 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Brouwer, P.J.M., Loeffler, J.R., Ferguson, J.A., Rodriguez, A.J., Han, J., Ward, A.B. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9ncd H L 0 A protein NA non-specific lipid-transfer protein ALLERGEN 02/18/26 Crystal structure of the peanut allergen Ara h 9 with bound Fab IGX-3103 and antiFab nanobody Arachis hypogaea; Homo sapiens; Lama glama homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A. 1.6 X-RAY DIFFRACTION 0.195 0.169 False True IGHV3 IGKV1 Kappa None None None None None 9ncd K NA 0 B carbohydrate NAG N-ACETYL-D-GLUCOSAMINE ALLERGEN 02/18/26 Crystal structure of the peanut allergen Ara h 9 with bound Fab IGX-3103 and antiFab nanobody Arachis hypogaea; Homo sapiens; Lama glama lama glama Pedersen, L.C., Mueller, G.A. 1.6 X-RAY DIFFRACTION 0.195 0.169 False True IGHV1 NA NA None None None None None 9nln A B 0 C nucleic-acid NA rna (cvb3 ires domain v) RNA/IMMUNE SYSTEM 02/18/26 Crystal Structure of Coxakievirus B3 IRES Domain V in Complex with a Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens coxsackievirus b3 (strain nancy) Das, N.K., Banna, H.A., Koirala, D. 3 X-RAY DIFFRACTION 0.264 0.216 False True IGHV3 IGKV1 Kappa None None None None None 9nln H L 0 R nucleic-acid NA rna (cvb3 ires domain v) RNA/IMMUNE SYSTEM 02/18/26 Crystal Structure of Coxakievirus B3 IRES Domain V in Complex with a Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens coxsackievirus b3 (strain nancy) Das, N.K., Banna, H.A., Koirala, D. 3 X-RAY DIFFRACTION 0.264 0.216 False True IGHV3 IGKV1 Kappa None None None None None 9nnz A NA 0 B protein NA rhodopsin MEMBRANE PROTEIN 02/18/26 Structure of rod opsin in complex with a megabody Bos taurus; synthetic construct synthetic construct bos taurus Suder, D.S., Gonen, S. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9noz A NA 0 C protein NA rhodopsin MEMBRANE PROTEIN 02/18/26 Structure of photoactivated rhodopsin in complex with a megabody Bos taurus; synthetic construct synthetic construct bos taurus Suder, D.S., Gonen, S. 3.48 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9noz B NA 0 D protein NA rhodopsin MEMBRANE PROTEIN 02/18/26 Structure of photoactivated rhodopsin in complex with a megabody Bos taurus; synthetic construct synthetic construct bos taurus Suder, D.S., Gonen, S. 3.48 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9oup H L 0 A protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 02/18/26 Native GABA-A receptor from rat cerebella, beta2-alpha1-beta1-alpha6-gamma2 subtype, in complex with GABA Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Sun, C., Gouaux, E. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9qtn F NA 0 A protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the F1 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qtn G NA 0 B protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the F1 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qtn H NA 0 C protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the F1 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qtn I NA 0 D protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the F1 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qtn J NA 0 E protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the F1 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qto F NA 0 A protein NA neuronal acetylcholine receptor subunit alpha-7,chrna7(exons 5-10) and fam7a (exons a-e) fusion MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the E6 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qto G NA 0 B protein NA neuronal acetylcholine receptor subunit alpha-7,chrna7(exons 5-10) and fam7a (exons a-e) fusion MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the E6 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qto H NA 0 C protein NA neuronal acetylcholine receptor subunit alpha-7,chrna7(exons 5-10) and fam7a (exons a-e) fusion MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the E6 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qto I NA 0 D protein NA neuronal acetylcholine receptor subunit alpha-7,chrna7(exons 5-10) and fam7a (exons a-e) fusion MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the E6 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qto J NA 0 E protein NA neuronal acetylcholine receptor subunit alpha-7,chrna7(exons 5-10) and fam7a (exons a-e) fusion MEMBRANE PROTEIN 02/18/26 Human alpha7 nicotinic receptor in complex with the E6 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Barilone, N., Vangelatou, M., Marouf, F.Z., Dejean de la Batie, G., Ayme, G., Lafaye, P., Corringer, P.-J., Prevost, M.S. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ssm H K 0 R protein NA spike glycoprotein ANTIVIRAL PROTEIN 02/18/26 Crystal structure of 084-7D Fab bound to SARS-CoV-2 Beta RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ayres, F., Moyo-Gwete, T., Wibmer, C.K. 2.7 X-RAY DIFFRACTION 0.269 0.223 False True IGHV3 IGKV1 Kappa None None None None None 9ugo B A 0 C protein NA middle s protein VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 Cryo-EM structure of the HBsAg dimer and Complex with Fab hepatitis B virus genotype A; Homo sapiens homo sapiens homo sapiens hepatitis b virus genotype a Liu, Y., Liao, M., Liu, Z., Ju, B., Zhang, Z. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9ugo F D 0 E protein NA middle s protein VIRAL PROTEIN/IMMUNE SYSTEM 02/18/26 Cryo-EM structure of the HBsAg dimer and Complex with Fab hepatitis B virus genotype A; Homo sapiens homo sapiens homo sapiens hepatitis b virus genotype a Liu, Y., Liao, M., Liu, Z., Ju, B., Zhang, Z. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9wrn H L 0 NA NA NA NA IMMUNE SYSTEM 02/18/26 Crystal structure of chimeric anti-Z-DNA Fab cZ22-Fab Mus musculus mus musculus mus musculus Lee, C.C., Hsu, S.F., Wang, A.H.J. 2.15 X-RAY DIFFRACTION 0.238 0.192 False True IGHV10 IGKV10 Kappa None None None None None 9wrn I M 0 NA NA NA NA IMMUNE SYSTEM 02/18/26 Crystal structure of chimeric anti-Z-DNA Fab cZ22-Fab Mus musculus mus musculus mus musculus Lee, C.C., Hsu, S.F., Wang, A.H.J. 2.15 X-RAY DIFFRACTION 0.238 0.192 False True IGHV10 IGKV10 Kappa None None None None None 9wrn J N 0 NA NA NA NA IMMUNE SYSTEM 02/18/26 Crystal structure of chimeric anti-Z-DNA Fab cZ22-Fab Mus musculus mus musculus mus musculus Lee, C.C., Hsu, S.F., Wang, A.H.J. 2.15 X-RAY DIFFRACTION 0.238 0.192 False True IGHV10 IGKV10 Kappa None None None None None 9wrn K O 0 NA NA NA NA IMMUNE SYSTEM 02/18/26 Crystal structure of chimeric anti-Z-DNA Fab cZ22-Fab Mus musculus mus musculus mus musculus Lee, C.C., Hsu, S.F., Wang, A.H.J. 2.15 X-RAY DIFFRACTION 0.238 0.192 False True IGHV10 IGKV10 Kappa None None None None None 9ws0 A B 0 N nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed d(CG)6 DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 3.27 X-RAY DIFFRACTION 0.239 0.199 False True IGHV10 IGKV10 Kappa None None None None None 9ws0 H L 0 N nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed d(CG)6 DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 3.27 X-RAY DIFFRACTION 0.239 0.199 False True IGHV10 IGKV10 Kappa None None None None None 9wu2 A B 0 F nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*c)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed dC(GC)3 DNA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 2.35 X-RAY DIFFRACTION 0.210 0.169 False True IGHV10 IGKV10 Kappa None None None None None 9wu2 C D 0 E nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*c)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed dC(GC)3 DNA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 2.35 X-RAY DIFFRACTION 0.210 0.169 False True IGHV10 IGKV10 Kappa None None None None None 9wu2 G H 0 L nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*c)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed dC(GC)3 DNA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 2.35 X-RAY DIFFRACTION 0.210 0.169 False True IGHV10 IGKV10 Kappa None None None None None 9wu2 I J 0 K nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*c)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed dC(GC)3 DNA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 2.35 X-RAY DIFFRACTION 0.210 0.169 False True IGHV10 IGKV10 Kappa None None None None None 9wu2 M N 0 R nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*c)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed dC(GC)3 DNA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 2.35 X-RAY DIFFRACTION 0.210 0.169 False True IGHV10 IGKV10 Kappa None None None None None 9wu2 O P 0 Q nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*c)-3') IMMUNE SYSTEM 02/18/26 Crystal structure of cZ22-Fab in complex with left-handed dC(GC)3 DNA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, C.C., Hsu, S.F., Ko, T.P., Wang, A.H.J. 2.35 X-RAY DIFFRACTION 0.210 0.169 False True IGHV10 IGKV10 Kappa None None None None None 9xsx B C 0 A protein NA hemagglutinin VIRAL PROTEIN 02/18/26 the complex structure of antibody CF22 bound to the hemagglutinin of influenza B virus (HA_B/Guangdong-Yuexiu/120/2022). Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Ge, J.W., Fan, M. 2.98 X-RAY DIFFRACTION 0.243 0.210 False True IGHV4 IGLV3 Lambda None None None None None 9xth B C 0 A protein NA hemagglutinin VIRAL PROTEIN 02/18/26 The complex structure of antibody CAV-CH76 bound to the hemagglutinin of influenza B virus (HA_B/Guangdong-Yuexiu/120/2022) Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Ge, J.W., Fan, M. 3.01 X-RAY DIFFRACTION 0.244 0.197 False True IGHV1 IGKV1 Kappa None None None None None 9d74 H L 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen b alpha chain (hla- | mhc class ii antigen peptide IMMUNE SYSTEM 02/11/26 CryoEM structure of anti-MHC-I Fab B1.23.2 complex with HLA-B44:05 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | synthetic construct Jiang, J., Natarajan, K., Margulies, D.H., Lei, H., Huang, R. 3.31 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV14 Kappa None None None None None 9uaq D NA 0 G | A protein | protein NA | NA green fluorescent protein | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of GFP-like protein from Aequorea coerulescens with Trimbody Aequorea coerulescens; synthetic construct; Thermotoga maritima MSB8 synthetic construct aequorea coerulescens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uaq E NA 0 H | B protein | protein NA | NA green fluorescent protein | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of GFP-like protein from Aequorea coerulescens with Trimbody Aequorea coerulescens; synthetic construct; Thermotoga maritima MSB8 synthetic construct aequorea coerulescens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uaq F NA 0 I | C protein | protein NA | NA green fluorescent protein | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of GFP-like protein from Aequorea coerulescens with Trimbody Aequorea coerulescens; synthetic construct; Thermotoga maritima MSB8 synthetic construct aequorea coerulescens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ubr G NA 0 M | A protein | protein NA | NA galectin-10 | prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of human Galectin-10 with iTrimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ubr H NA 0 N | B protein | protein NA | NA galectin-10 | prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of human Galectin-10 with iTrimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ubr I NA 0 O | C protein | protein NA | NA galectin-10 | prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of human Galectin-10 with iTrimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ubr J NA 0 P | D protein | protein NA | NA galectin-10 | prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of human Galectin-10 with iTrimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ubr K NA 0 Q | E protein | protein NA | NA galectin-10 | prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of human Galectin-10 with iTrimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ubr L NA 0 R | F protein | protein NA | NA galectin-10 | prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of human Galectin-10 with iTrimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ucl D NA 0 G | A protein | protein NA | NA nectin-4 | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of IgV domain of human Nectin-4 with Trimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.43 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ucl E NA 0 H | B protein | protein NA | NA nectin-4 | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of IgV domain of human Nectin-4 with Trimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.43 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ucl F NA 0 I | C protein | protein NA | NA nectin-4 | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of IgV domain of human Nectin-4 with Trimbody Homo sapiens; synthetic construct; Thermotoga maritima MSB8 synthetic construct homo sapiens | synthetic construct, thermotoga maritima msb8 Song, J.Y., Wang, W. 2.43 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9xou D NA 0 G | A protein | protein NA | NA lactose permease | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of LacY with Trimbody Escherichia coli K-12; synthetic construct; Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) synthetic construct escherichia coli k-12 | synthetic construct, thermotoga maritima(strain atcc 43589 / dsm 3109 / jcm 10099 / nbrc 100826 / msb8) Song, J.Y., Wang, W. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9xou E NA 0 H | B protein | protein NA | NA lactose permease | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of LacY with Trimbody Escherichia coli K-12; synthetic construct; Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) synthetic construct escherichia coli k-12 | synthetic construct, thermotoga maritima(strain atcc 43589 / dsm 3109 / jcm 10099 / nbrc 100826 / msb8) Song, J.Y., Wang, W. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9xou F NA 0 I | C protein | protein NA | NA lactose permease | h3-prac-5350a,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase STRUCTURAL PROTEIN 02/11/26 CryoEM structure of LacY with Trimbody Escherichia coli K-12; synthetic construct; Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) synthetic construct escherichia coli k-12 | synthetic construct, thermotoga maritima(strain atcc 43589 / dsm 3109 / jcm 10099 / nbrc 100826 / msb8) Song, J.Y., Wang, W. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 21du N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/11/26 Cryo-EM structure of the apomorphine bound ADGRG6-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Han, S., Wu, B., Zhao, Q. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9gei B b 0 A protein NA galactose/n-acetyl-d-galactosamine lectin heavy subunit 1 CELL ADHESION 02/11/26 Entamoeba histolytica Gal/GalNAc lectin heavy chain residues 808-992 in the presence of monoclonal antibody CP33-H/L-LA22 Entamoeba histolytica; Homo sapiens homo sapiens entamoeba histolytica Gerard, S.F., Higgins, M.K. 3.034 X-RAY DIFFRACTION 0.277 0.242 True True unknown unknown unknown None None None None None 9gei D d 0 C protein NA galactose/n-acetyl-d-galactosamine lectin heavy subunit 1 CELL ADHESION 02/11/26 Entamoeba histolytica Gal/GalNAc lectin heavy chain residues 808-992 in the presence of monoclonal antibody CP33-H/L-LA22 Entamoeba histolytica; Homo sapiens homo sapiens entamoeba histolytica Gerard, S.F., Higgins, M.K. 3.034 X-RAY DIFFRACTION 0.277 0.242 True True unknown unknown unknown None None None None None 9gjg A a 0 H protein NA galactose/n-acetyl-d-galactosamine lectin heavy subunit 1 CELL ADHESION 02/11/26 Entamoeba histolytica Gal/GalNAc lectin bound to monoclonal antibody CP33-H/L-LA22 Entamoeba histolytica HM-1:IMSS; Homo sapiens homo sapiens entamoeba histolytica hm-1 Gerard, S.F., Higgins, M.K. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9n7m H L 0 NA NA NA NA IMMUNE SYSTEM 02/11/26 Designed anti-OSM Fab Rattus norvegicus rattus norvegicus rattus norvegicus Kiefer, J.R., Alberstein, R.G., Hofmann, J.L., Watkins, A.M., Seeger, F., Dou, Y., Zhang, X. 2.15 X-RAY DIFFRACTION 0.242 0.210 False True IGHV3 IGKV3 Kappa None None None None None 9n7m A B 0 NA NA NA NA IMMUNE SYSTEM 02/11/26 Designed anti-OSM Fab Rattus norvegicus rattus norvegicus rattus norvegicus Kiefer, J.R., Alberstein, R.G., Hofmann, J.L., Watkins, A.M., Seeger, F., Dou, Y., Zhang, X. 2.15 X-RAY DIFFRACTION 0.242 0.210 False True IGHV3 IGKV3 Kappa None None None None None 9n7o H L 0 NA NA NA NA IMMUNE SYSTEM 02/11/26 Designed anti-OSM Fab Rattus norvegicus rattus norvegicus rattus norvegicus Kiefer, J.R., Alberstein, R.G., Hofmann, J.L., Watkins, A.M., Seeger, F., Dou, Y., Zhang, X. 1.48 X-RAY DIFFRACTION 0.205 0.172 False True IGHV3 IGKV3 Kappa None None None None None 9qrv H L 0 D protein NA von willebrand factor BLOOD CLOTTING 02/11/26 Crystal Structure of an anti-VWF CK Domain Fab in Complex with the C-Terminal CK Domain of Cynomolgus Monkey von Willebrand Factor. Macaca fascicularis; synthetic construct synthetic construct synthetic construct macaca fascicularis Bak-Thomsen, T., Hager, M., Carnbring Deemand, A., Gluver Norgaard, H., Kempf-Amkaer, L., Anthonsen, A., Nielsen, R., Naretto, A., Kelpsas, V., Sabljic, I., Rose, N., Ostergaard, H., Gandhi, P., Walse, B. 2.5 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 IGKV1 Kappa None None None None None 9th6 B NA 0 A protein NA guanine-n7 methyltransferase nsp14 VIRAL PROTEIN 02/11/26 nsp14 of SARS-CoV-2 in complex with a camelid nanobody Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Gauffre, P., Ferron, F., Canard, B. 2.267 X-RAY DIFFRACTION 0.290 0.233 False True IGHV1 NA NA None None None None None 9vz8 H L 0 E | D | C protein | protein | protein NA | NA | NA major capsid protein l1 | major capsid protein l1 | major capsid protein l1 VIRUS LIKE PARTICLE 02/11/26 Local refinement region of HPV45 in complex with antibody 10G2 human papillomavirus 45; Mus musculus mus musculus mus musculus human papillomavirus 45 | human papillomavirus 45 | human papillomavirus 45 Jiang, Y., Sun, H., Zheng, Q., Li, S. 3.81 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 9y0a A B 0 C protein NA major pollen allergen bet v 1-a ALLERGEN/IMMUNE SYSTEM 02/11/26 Crystal structure of Bet v 1.0101 in complex with human IgE Fab 2H22 Betula pendula; Homo sapiens homo sapiens homo sapiens betula pendula O'Malley, A., Borders, B.T., Smith, S.A., Chruszcz, M. 2.12 X-RAY DIFFRACTION 0.218 0.171 False True IGHV4 IGLV1 Lambda None None None None None 9y0d A B 0 NA NA NA NA IMMUNE SYSTEM 02/11/26 Crystal structure of human IgE Fab 2H22 Homo sapiens homo sapiens homo sapiens O'Malley, A., Borders, B.T., Smith, S.A., Chruszcz, M. 2.27 X-RAY DIFFRACTION 0.244 0.187 False True IGHV4 IGLV1 Lambda None None None None None 9y0e A B 0 C protein NA major pollen allergen bet v 1-a ALLERGEN/IMMUNE SYSTEM 02/11/26 Crystal structure of Bet v 1.0101 in complex with human IgE Fab 2H22 Betula pendula; Homo sapiens homo sapiens homo sapiens betula pendula O'Malley, A., Borders, B.T., Smith, S.A., Chruszcz, M. 2.9 X-RAY DIFFRACTION 0.257 0.196 False True IGHV4 IGLV1 Lambda None None None None None 9yy0 H L 0 NA NA NA NA IMMUNE SYSTEM 02/11/26 IGHV4-34 germline-reverted antibody pre166 Homo sapiens homo sapiens homo sapiens Langley, D.B., Christ, D. 1.34 X-RAY DIFFRACTION 0.253 0.224 False True IGHV4 IGKV3 Kappa None None None None None 9d72 H L 0 B | A protein | protein NA | NA beta-2-microglobulin | h-2 class i histocompatibility antigen, d-d alpha chain ANTITUMOR PROTEIN/Immune System 02/04/26 CryoEM structure of anti-MHC-I Fab M1/42 complex with H2-Dd Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus mus musculus | mus musculus Jiang, J., Natarajan, K., Margulies, D.H., Lei, H., Huang, R. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV14 Kappa None None None None None 9d73 H L 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen b alpha chain (hla- | mhc class ii antigen peptide ANTITUMOR PROTEIN/Immune System 02/04/26 CryoEM structure of anti-MHC-I mAb B1.23.2 complex with HLA-B44:05 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | synthetic construct Jiang, J., Natarajan, K., Lei, H., Huang, R., Margulies, D.H. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV14 Kappa None None None None None 9lr1 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound APLNR monomer-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lr1 C NA 0 R protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound APLNR monomer-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lr2 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound APLNR dimer-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lr2 D NA 0 Q protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound APLNR dimer-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lr2 C NA 0 R protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound APLNR dimer-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9o8q H L 0 B | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2) Homo sapiens; Influenza A virus (A/Hong Kong/485197/2014(H3N2)) homo sapiens homo sapiens influenza a virus (a/hongkong/485197/2014(h3n2)) | influenza a virus (a/hongkong/485197/2014(h3n2)) Jo, G., Ward, A.B. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9o8q G J 0 E | D protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2) Homo sapiens; Influenza A virus (A/Hong Kong/485197/2014(H3N2)) homo sapiens homo sapiens influenza a virus (a/hongkong/485197/2014(h3n2)) | influenza a virus (a/hongkong/485197/2014(h3n2)) Jo, G., Ward, A.B. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9o8q I K 0 F | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2) Homo sapiens; Influenza A virus (A/Hong Kong/485197/2014(H3N2)) homo sapiens homo sapiens influenza a virus (a/hongkong/485197/2014(h3n2)) | influenza a virus (a/hongkong/485197/2014(h3n2)) Jo, G., Ward, A.B. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9o8r H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin Viral protein/Immune System 02/04/26 Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1) Homo sapiens; Influenza A virus (A/Michigan/45/2015(H1N1)) homo sapiens homo sapiens influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Jo, G., Ward, A.B. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9o8r G J 0 E | C protein | protein NA | NA hemagglutinin | hemagglutinin Viral protein/Immune System 02/04/26 Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1) Homo sapiens; Influenza A virus (A/Michigan/45/2015(H1N1)) homo sapiens homo sapiens influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Jo, G., Ward, A.B. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9o8r I K 0 F | D protein | protein NA | NA hemagglutinin | hemagglutinin Viral protein/Immune System 02/04/26 Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1) Homo sapiens; Influenza A virus (A/Michigan/45/2015(H1N1)) homo sapiens homo sapiens influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Jo, G., Ward, A.B. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9o8s H L 0 B | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2) Homo sapiens; Influenza A virus (A/Hong Kong/485197/2014(H3N2)) homo sapiens homo sapiens influenza a virus (a/hongkong/485197/2014(h3n2)) | influenza a virus (a/hongkong/485197/2014(h3n2)) Jo, G., Ward, A.B. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o8s G J 0 E | D protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2) Homo sapiens; Influenza A virus (A/Hong Kong/485197/2014(H3N2)) homo sapiens homo sapiens influenza a virus (a/hongkong/485197/2014(h3n2)) | influenza a virus (a/hongkong/485197/2014(h3n2)) Jo, G., Ward, A.B. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o8s I K 0 F | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2) Homo sapiens; Influenza A virus (A/Hong Kong/485197/2014(H3N2)) homo sapiens homo sapiens influenza a virus (a/hongkong/485197/2014(h3n2)) | influenza a virus (a/hongkong/485197/2014(h3n2)) Jo, G., Ward, A.B. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o8t H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1) Homo sapiens; Influenza A virus (A/Michigan/45/2015(H1N1)) homo sapiens homo sapiens influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Jo, G., Ward, A.B. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o8t G J 0 E | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1) Homo sapiens; Influenza A virus (A/Michigan/45/2015(H1N1)) homo sapiens homo sapiens influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Jo, G., Ward, A.B. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o8t I K 0 F | D protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 Viral protein/Immune System 02/04/26 Cryo-EM structure of NI04359_d30_240 Fab in complex with influenza virus hemagglutinin from A/Michigan/45/2015 (H1N1) Homo sapiens; Influenza A virus (A/Michigan/45/2015(H1N1)) homo sapiens homo sapiens influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Jo, G., Ward, A.B. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oi2 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/26 Structure of human Fab 245 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Pholcharee, T., Lv, H. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9oi2 I J 0 F | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/26 Structure of human Fab 245 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Pholcharee, T., Lv, H. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9oi3 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/26 Structure of human Fab 604 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Pholcharee, T., Lv, H. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9oi3 I J 0 F | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/26 Structure of human Fab 604 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Pholcharee, T., Lv, H. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9oi3 M N 0 D | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/26 Structure of human Fab 604 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Pholcharee, T., Lv, H. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 22ps A B 0 C protein NA ige-fc IMMUNE SYSTEM 02/04/26 Structure of ozureprubart Fab in complex with human IgE-Fc Homo sapiens homo sapiens homo sapiens homo sapiens Zhou, F., Liu, P.P. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 22ps D E 0 F protein NA ige-fc IMMUNE SYSTEM 02/04/26 Structure of ozureprubart Fab in complex with human IgE-Fc Homo sapiens homo sapiens homo sapiens homo sapiens Zhou, F., Liu, P.P. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9i3w H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-8C Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.14 X-RAY DIFFRACTION 0.194 0.166 False True IGHV4 IGLV1 Lambda None None None None None 9i3x H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-11B Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.57 X-RAY DIFFRACTION 0.255 0.209 False True IGHV1 IGLV2 Lambda None None None None None 9i3x B A 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-11B Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.57 X-RAY DIFFRACTION 0.255 0.209 False True IGHV1 IGLV2 Lambda None None None None None 9i3z H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-12D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 3.06 X-RAY DIFFRACTION 0.256 0.210 False True IGHV4 IGLV1 Lambda None None None None None 9i3z A B 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-12D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 3.06 X-RAY DIFFRACTION 0.256 0.210 False True IGHV4 IGLV1 Lambda None None None None None 9i40 H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-3-4D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.78 X-RAY DIFFRACTION 0.277 0.241 False True IGHV4 IGLV1 Lambda None None None None None 9i40 B A 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-3-4D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.78 X-RAY DIFFRACTION 0.277 0.241 False True IGHV4 IGLV1 Lambda None None None None None 9i41 H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-3-3C Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.32 X-RAY DIFFRACTION 0.174 0.143 False True IGHV3 IGLV2 Lambda None None None None None 9i42 H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-2D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.92 X-RAY DIFFRACTION 0.192 0.164 False True IGHV1 IGLV1 Lambda None None None None None 9i42 B A 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-2D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.92 X-RAY DIFFRACTION 0.192 0.164 False True IGHV1 IGLV1 Lambda None None None None None 9i43 H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-2-9D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.18 X-RAY DIFFRACTION 0.176 0.145 False True IGHV4 IGLV1 Lambda None None None None None 9i45 H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 16-3-10B Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.12 X-RAY DIFFRACTION 0.236 0.204 False True IGHV7 IGLV2 Lambda None None None None None 9i4b H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 17-2-12A Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.68 X-RAY DIFFRACTION 0.253 0.208 False True IGHV3 IGLV7 Lambda None None None None None 9i4b A B 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 17-2-12A Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.68 X-RAY DIFFRACTION 0.253 0.208 False True IGHV3 IGLV7 Lambda None None None None None 9i4c H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 17-1-12A Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.83 X-RAY DIFFRACTION 0.267 0.223 False True IGHV3 IGKV2 Kappa None None None None None 9i4d H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 17-2-2B Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.56 X-RAY DIFFRACTION 0.243 0.194 False True IGHV4 IGLV2 Lambda None None None None None 9i4d A B 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 17-2-2B Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 2.56 X-RAY DIFFRACTION 0.243 0.194 False True IGHV4 IGLV2 Lambda None None None None None 9i4e H L 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 34-1-6D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.63 X-RAY DIFFRACTION 0.209 0.158 False True IGHV7 IGKV1 Kappa None None None None None 9i4e A B 0 NA NA NA NA ANTIVIRAL PROTEIN 02/04/26 Structure of anti-EV71 human monoclonal antibody 34-1-6D Fab Homo sapiens homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.63 X-RAY DIFFRACTION 0.209 0.158 False True IGHV7 IGKV1 Kappa None None None None None 9lqu D NA 0 B protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound state 1a of APLNR homodimer Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lqu C NA 0 A protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound state 1a of APLNR homodimer Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lqw C NA 0 A protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound state 1b of APLNR homodimer Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lqw D NA 0 B protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound state 1b of APLNR homodimer Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lqx D NA 0 B protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound state 1c of APLNR homodimer Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lqx C NA 0 A protein NA apelin receptor STRUCTURAL PROTEIN 02/04/26 Cryo-EM structure of the JN241-9-bound state 1c of APLNR homodimer Homo sapiens; synthetic construct synthetic construct homo sapiens Ji, S., Wang, W., Yang, Y., Shen, Q., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9n2v H L 0 NA NA NA NA IMMUNE SYSTEM 02/04/26 Designed anti-OSM Fab Rattus norvegicus rattus norvegicus rattus norvegicus Kiefer, J.R., Alberstein, R.G., Watkins, A.M., Seeger, F., Frey, N.C., Bonneau, R., Regev, A., Hofmann, J.L., Gligorijevic, V. 1.97 X-RAY DIFFRACTION 0.202 0.174 False True IGHV3 IGKV3 Kappa None None None None None 9n2v A B 0 NA NA NA NA IMMUNE SYSTEM 02/04/26 Designed anti-OSM Fab Rattus norvegicus rattus norvegicus rattus norvegicus Kiefer, J.R., Alberstein, R.G., Watkins, A.M., Seeger, F., Frey, N.C., Bonneau, R., Regev, A., Hofmann, J.L., Gligorijevic, V. 1.97 X-RAY DIFFRACTION 0.202 0.174 False True IGHV3 IGKV3 Kappa None None None None None 9n38 H L 0 A protein NA leukocidin-like protein 1 IMMUNE SYSTEM/Toxin 02/04/26 Cryo EM structure of LukAB (LukGH) toxin from Staphylococcus aureus in complex with neutralizing Fab STAU-15 Homo sapiens; Staphylococcus aureus homo sapiens homo sapiens staphylococcus aureus Binshtein, E., Crowe, J.E. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9n8i A B 0 E protein NA gametocyte surface protein p230 IMMUNE SYSTEM 02/04/26 Pfs230 domain 1 bound by RUPA-39 Fab Homo sapiens; Lama glama; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Ivanochko, D., Semesi, A., Julien, J.P. 1.85 X-RAY DIFFRACTION 0.233 0.188 False True IGHV3 IGKV3 Kappa None None None None None 9n8i F NA 0 NA NA NA NA IMMUNE SYSTEM 02/04/26 Pfs230 domain 1 bound by RUPA-39 Fab Homo sapiens; Lama glama; Plasmodium falciparum 3D7 lama glama Ivanochko, D., Semesi, A., Julien, J.P. 1.85 X-RAY DIFFRACTION 0.233 0.188 False True IGHV1 NA NA None None None None None 9n8j B C 0 X protein NA gametocyte surface protein p230,gametocyte surface proteinp45/48 IMMUNE SYSTEM 02/04/26 Stabilized tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs Homo sapiens; Plasmodium falciparum; Rattus homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., Ivanochko, D., Julien, J.P. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9n8j D E 0 X protein NA gametocyte surface protein p230,gametocyte surface proteinp45/48 IMMUNE SYSTEM 02/04/26 Stabilized tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs Homo sapiens; Plasmodium falciparum; Rattus homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., Ivanochko, D., Julien, J.P. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9n8j F G 0 X protein NA gametocyte surface protein p230,gametocyte surface proteinp45/48 IMMUNE SYSTEM 02/04/26 Stabilized tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs Homo sapiens; Plasmodium falciparum; Rattus rattus rattus plasmodium falciparum Hailemariam, S., Ivanochko, D., Julien, J.P. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 9n8j H I 0 X protein NA gametocyte surface protein p230,gametocyte surface proteinp45/48 IMMUNE SYSTEM 02/04/26 Stabilized tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs Homo sapiens; Plasmodium falciparum; Rattus homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., Ivanochko, D., Julien, J.P. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9n8n A B 0 I protein NA gametocyte surface protein p230,gametocyte surface proteinp45/48 IMMUNE SYSTEM 02/04/26 Tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Ivanochko, D., Semesi, A., Julien, J.P. 2.22 X-RAY DIFFRACTION 0.210 0.174 False True IGHV3 IGKV3 Kappa None None None None None 9n8n F E 0 I protein NA gametocyte surface protein p230,gametocyte surface proteinp45/48 IMMUNE SYSTEM 02/04/26 Tandem antigen chimera of Pfs230 and Pfs48/45 bound by potent mAbs Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Ivanochko, D., Semesi, A., Julien, J.P. 2.22 X-RAY DIFFRACTION 0.210 0.174 False True IGHV4 IGKV1 Kappa None None None None None 9o8m A B 0 K protein NA envelope glycoprotein gp160 VIRAL PROTEIN 02/04/26 Ab1983 in complex with HIV-1 Env variant WIN332 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Lin, Z.J., Cui, J., Du, J., Relano-Rodriguez, I., Escolano, A., Pallesen, J. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV9 Lambda None None None None None 9o8m C D 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN 02/04/26 Ab1983 in complex with HIV-1 Env variant WIN332 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Lin, Z.J., Cui, J., Du, J., Relano-Rodriguez, I., Escolano, A., Pallesen, J. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV9 Lambda None None None None None 9v0x E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(324) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/04/26 Cryo-EM structure of Gq-coupled PrRPR in complex with GUB08248 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Zhao, L., Li, X., Li, S., Yuan, Q., Xu, H.E. 2.66 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9v1h E e 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/04/26 Cryo-EM structure of Gi-coupled NPFF2R in complex with GUB08248 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens | homo sapiens Zhao, L., Li, X., Li, S., Yuan, Q. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9vjj H L 0 B protein NA transforming growth factor beta-1 proprotein CYTOKINE 02/04/26 Crystal Structure of human Latent TGF-beta1 in complex with SOF10 Homo sapiens homo sapiens homo sapiens homo sapiens Kawauchi, H., Kanamori, M., Sato, I., Fukami, T.A., Irie, M., Torizawa, T., Shimada, H. 2.477 X-RAY DIFFRACTION 0.310 0.281 False True IGHV3 IGKV1 Kappa None None None None None 9vjj I M 0 A protein NA transforming growth factor beta-1 proprotein CYTOKINE 02/04/26 Crystal Structure of human Latent TGF-beta1 in complex with SOF10 Homo sapiens homo sapiens homo sapiens homo sapiens Kawauchi, H., Kanamori, M., Sato, I., Fukami, T.A., Irie, M., Torizawa, T., Shimada, H. 2.477 X-RAY DIFFRACTION 0.310 0.281 False True IGHV3 IGKV1 Kappa None None None None None 9xqc E e 0 A | C protein | protein NA | NA g subunit alpha (q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/04/26 A composite Cryo-EM structure of GPR75 Escherichia coli K-12; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yuan, Q., Wu, C. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9xqn C B 0 A protein NA probable g-protein coupled receptor 75,soluble cytochromeb562 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/04/26 Cryo-EM structure of apo form of GPR75-bRIL-Fab complex Escherichia coli; Homo sapiens homo sapiens homo sapiens homo sapiens, escherichia coli Wu, C., Yuan, Q. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9yc5 H L 0 A protein NA urokinase plasminogen activator surface receptor IMMUNE SYSTEM 02/04/26 Human uPAR bound to the Fab fragment of targeted cancer therapeutic antibody FL1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Anane, R.F., Whisstock, J.C., Engelholm, L.H., Law, R.H.P., Ploug, M. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9yio D C 0 B protein NA pvripr egf7-8 CELL INVASION 02/04/26 Crystal structure of 5B3 Fab in complex with PvRipr EGF7-8 Mus musculus; Plasmodium vivax mus musculus mus musculus plasmodium vivax Xiao, X., Cowman, A.F., Scally, S.W. 2.08 X-RAY DIFFRACTION 0.235 0.204 False True IGHV14 IGKV4 Kappa None None None None None 9zwe H I 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/04/26 Soluble ectodomain of Herpes simplex virus 2 (HSV-2) glycoprotein B (gB) in the prefusion conformation in complex with 2c and D48 Fabs Homo sapiens; Human herpesvirus 2 strain HG52; Mus musculus homo sapiens homo sapiens human herpesvirus 2 strain hg52 Sponholtz, M.R., Johnson, N.V., McLellan, J.S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9zwe J K 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/04/26 Soluble ectodomain of Herpes simplex virus 2 (HSV-2) glycoprotein B (gB) in the prefusion conformation in complex with 2c and D48 Fabs Homo sapiens; Human herpesvirus 2 strain HG52; Mus musculus mus musculus mus musculus human herpesvirus 2 strain hg52 Sponholtz, M.R., Johnson, N.V., McLellan, J.S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV1 Kappa None None None None None 9zwe C D 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/04/26 Soluble ectodomain of Herpes simplex virus 2 (HSV-2) glycoprotein B (gB) in the prefusion conformation in complex with 2c and D48 Fabs Homo sapiens; Human herpesvirus 2 strain HG52; Mus musculus homo sapiens homo sapiens human herpesvirus 2 strain hg52 Sponholtz, M.R., Johnson, N.V., McLellan, J.S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9zwe E F 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/04/26 Soluble ectodomain of Herpes simplex virus 2 (HSV-2) glycoprotein B (gB) in the prefusion conformation in complex with 2c and D48 Fabs Homo sapiens; Human herpesvirus 2 strain HG52; Mus musculus mus musculus mus musculus human herpesvirus 2 strain hg52 Sponholtz, M.R., Johnson, N.V., McLellan, J.S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV1 Kappa None None None None None 9zwe L M 0 G protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/04/26 Soluble ectodomain of Herpes simplex virus 2 (HSV-2) glycoprotein B (gB) in the prefusion conformation in complex with 2c and D48 Fabs Homo sapiens; Human herpesvirus 2 strain HG52; Mus musculus homo sapiens homo sapiens human herpesvirus 2 strain hg52 Sponholtz, M.R., Johnson, N.V., McLellan, J.S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9zwe N O 0 G protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/04/26 Soluble ectodomain of Herpes simplex virus 2 (HSV-2) glycoprotein B (gB) in the prefusion conformation in complex with 2c and D48 Fabs Homo sapiens; Human herpesvirus 2 strain HG52; Mus musculus mus musculus mus musculus human herpesvirus 2 strain hg52 Sponholtz, M.R., Johnson, N.V., McLellan, J.S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV1 Kappa None None None None None 9rxi H NA 0 B protein NA cathepsin d (a01 family) HYDROLASE 01/28/26 Schistosoma mansoni Cathepsin D1 bound to Nb10C9 Lama glama; Schistosoma mansoni lama glama schistosoma mansoni Parker, K., Clarke, J.D., Owens, R.J. 2.59 X-RAY DIFFRACTION 0.234 0.173 False True IGHV1 NA NA None None None None None 9rxi E NA 0 NA NA NA NA HYDROLASE 01/28/26 Schistosoma mansoni Cathepsin D1 bound to Nb10C9 Lama glama; Schistosoma mansoni lama glama Parker, K., Clarke, J.D., Owens, R.J. 2.59 X-RAY DIFFRACTION 0.234 0.173 False True IGHV1 NA NA None None None None None 9con E NA 0 C protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 1 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9con F NA 0 B protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 1 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9con G NA 0 D protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 1 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9con H NA 0 A protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 1 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cty E NA 0 B protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 2 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cty F NA 0 C protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 2 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cty G NA 0 D protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 2 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cty H NA 0 A protein NA potassium voltage-gated channel subfamily a member 3/mvenusfusion protein,green fluorescent protein IMMUNE SYSTEM 01/28/26 Human Kv1.3-H451V with A0194009G09 nanobodies conformation 2 Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Selvakumar, P., Swartz, K.J. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ivj H L 0 C | A protein | protein NA | NA soluble gp42 | envelope glycoprotein h VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of EBV gH/gL/gp42 in complex with fab 4G12 Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 | human gammaherpesvirus 4 Fang, X.Y., Zhao, G.X., Liu, Z., Zeng, M.S. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 9ldx S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(olf) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/28/26 Consensus olfactory receptor consOR6 in complex with mini-Golf trimeric protein Homo sapiens; Mus musculoides; synthetic construct mus musculoides homo sapiens | homo sapiens Wang, T., Wu, L.J., Hua, T., Liu, Z.J. 2.83 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9le0 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(olf) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/28/26 Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein Homo sapiens; Mus musculoides; synthetic construct mus musculoides homo sapiens | homo sapiens Wang, T., Wu, L.J., Hua, T., Liu, Z.J. 2.54 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9loe B C 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of SFTSV Gn in complex with ZS004-1C5 Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Bi, J.H., Zhang, Y.Y., Zhou, Q., Li, D.P. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9lof B C 0 A protein NA envelopment polyprotein VIRAL PROTEIN 01/28/26 Cryo-EM structure of SFTSV Gn in complex with ZS01S-336 Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Bi, J.H., Zhang, Y.Y., Zhou, Q., Li, D.P. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9log B C 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of SFTSV Gn in complex with ZS01S-65 Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Bi, J.H., Zhang, Y.Y., Zhou, Q., Li, D.P. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9loy E F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of SARS-CoV-2 JN.1 spike glycoprotein in complex with F61R2-780 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9loy H I 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of SARS-CoV-2 JN.1 spike glycoprotein in complex with F61R2-780 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9loz B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of SARS-CoV-2 JN.1 RBD in complex with F61R2-780 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9lp0 D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of SARS-CoV-2 KP.3.1.1 spike glycoprotein in complex with F61R2-780 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9lp1 A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of SARS-CoV-2 KP.3.1.1 RBD in complex with F61R2-780 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9n09 N NA 0 A | G | B protein | protein | protein NA | NA | NA mini-gs/i chimera | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/28/26 Human M4 muscarinic acetylcholine receptor Gi1 complex (mini-Gsi chimera) bound to the bitopic agonist C110 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Kaoullas, M.G., Mobbs, J.I., Venugopal, H., Thal, D.M. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9t9m H L 0 NA NA NA NA ANTITUMOR PROTEIN 01/28/26 Tilvestamab Fab bound to the anti-Fab nanobody Mus sp. mus sp. mus sp. Lopez, A.J., Christakou, E., Kursula, P. 3.09 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 9t9m K NA 0 NA NA NA NA ANTITUMOR PROTEIN 01/28/26 Tilvestamab Fab bound to the anti-Fab nanobody Mus sp. mus sp. Lopez, A.J., Christakou, E., Kursula, P. 3.09 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9vnp C A 0 L protein NA interferon gamma IMMUNE SYSTEM 01/28/26 The complexes of IFN-gamma and A01BM-03 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Wang, X., Zhang, L., Wang, H., Yu, J. 2.8 X-RAY DIFFRACTION 0.248 0.229 False True IGHV3 IGLV6 Lambda None None None None None 9vq6 A NA 0 NA NA NA NA IMMUNE SYSTEM 01/28/26 Strcture of Nanobody (NB) specific to Interleukin-6 Camelus dromedarius camelus dromedarius Talwar, C.S., Ahn, W.C., Lee, S.J., Woo, E.J. 2.86 X-RAY DIFFRACTION 0.285 0.233 False True IGHV3 NA NA None None None None None 9vq6 B NA 0 NA NA NA NA IMMUNE SYSTEM 01/28/26 Strcture of Nanobody (NB) specific to Interleukin-6 Camelus dromedarius camelus dromedarius Talwar, C.S., Ahn, W.C., Lee, S.J., Woo, E.J. 2.86 X-RAY DIFFRACTION 0.285 0.233 False True IGHV3 NA NA None None None None None 9vq6 C NA 0 NA NA NA NA IMMUNE SYSTEM 01/28/26 Strcture of Nanobody (NB) specific to Interleukin-6 Camelus dromedarius camelus dromedarius Talwar, C.S., Ahn, W.C., Lee, S.J., Woo, E.J. 2.86 X-RAY DIFFRACTION 0.285 0.233 False True IGHV3 NA NA None None None None None 9vq6 H NA 0 NA NA NA NA IMMUNE SYSTEM 01/28/26 Strcture of Nanobody (NB) specific to Interleukin-6 Camelus dromedarius camelus dromedarius Talwar, C.S., Ahn, W.C., Lee, S.J., Woo, E.J. 2.86 X-RAY DIFFRACTION 0.285 0.233 False True IGHV3 NA NA None None None None None 9wpm S s 0 C protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of the apo-ConsOR5-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens Rong, N.K., Zhang, M.H., Yang, F., Sun, J.P. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9wpm N NA 0 B protein NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/28/26 Cryo-EM structure of the apo-ConsOR5-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens Rong, N.K., Zhang, M.H., Yang, F., Sun, J.P. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8u9s M m 0 C | D protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of NRCAM nucleosome aided by scFv Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8u9s N n 0 G | H protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of NRCAM nucleosome aided by scFv Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubi M m 0 C | D protein | protein NA | NA histone h2a | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of NRCAM nucleosome aided by scFv (Class_A) Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubi N n 0 G | H protein | protein NA | NA histone h2a | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of NRCAM nucleosome aided by scFv (Class_A) Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubj M m 0 C | D protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of NRCAM nucleosome aided by scFv (3D Flex map) Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubj N n 0 G | H protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of NRCAM nucleosome aided by scFv (3D Flex map) Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubk M m 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of Ascl1/E12a in complex with NRCAM nucleosome Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubk N n 0 G | H protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of Ascl1/E12a in complex with NRCAM nucleosome Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubl M m 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of Ascl1/E12a in complex with NRCAM nucleosome (3D Flex map) Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ubl N n 0 G | H protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN 01/21/26 Cryo-EM structure of Ascl1/E12a in complex with NRCAM nucleosome (3D Flex map) Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9irs H L 0 f | n protein | protein NA | NA unknown | unknown IMMUNE SYSTEM 01/21/26 Cryo-EM structure of the TCR-OKT3 complex Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Li, X., Zhu, Y., Huang, Z. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9irs S T 0 e protein NA unknown IMMUNE SYSTEM 01/21/26 Cryo-EM structure of the TCR-OKT3 complex Homo sapiens homo sapiens homo sapiens homo sapiens Li, X., Zhu, Y., Huang, Z. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9z3b B A 0 I peptide NA mesothelin ANTITUMOR PROTEIN/IMMUNE SYSTEM 01/21/26 Structure C-terminal human Mesothelin Peptide bound to MSLNB703 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Shaffer, P.L., Ember, S. 1.96 X-RAY DIFFRACTION 0.278 0.227 False True IGHV6 IGKV4 Kappa None None None None None 9z3b D C 0 J peptide NA mesothelin ANTITUMOR PROTEIN/IMMUNE SYSTEM 01/21/26 Structure C-terminal human Mesothelin Peptide bound to MSLNB703 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Shaffer, P.L., Ember, S. 1.96 X-RAY DIFFRACTION 0.278 0.227 False True IGHV6 IGKV4 Kappa None None None None None 9z3b F E 0 K peptide NA mesothelin ANTITUMOR PROTEIN/IMMUNE SYSTEM 01/21/26 Structure C-terminal human Mesothelin Peptide bound to MSLNB703 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Shaffer, P.L., Ember, S. 1.96 X-RAY DIFFRACTION 0.278 0.227 False True IGHV6 IGKV4 Kappa None None None None None 9z3b H G 0 L peptide NA mesothelin ANTITUMOR PROTEIN/IMMUNE SYSTEM 01/21/26 Structure C-terminal human Mesothelin Peptide bound to MSLNB703 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Shaffer, P.L., Ember, S. 1.96 X-RAY DIFFRACTION 0.278 0.227 False True IGHV6 IGKV4 Kappa None None None None None 9ck4 A B 0 W protein NA l9 epitope scaffold IMMUNE SYSTEM 01/21/26 L9 epitope scaffold complexed with L9 Fabs Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Raghavan, S.S.R., Lee, W.H., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ck4 E F 0 W protein NA l9 epitope scaffold IMMUNE SYSTEM 01/21/26 L9 epitope scaffold complexed with L9 Fabs Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Raghavan, S.S.R., Lee, W.H., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ck4 C D 0 W protein NA l9 epitope scaffold IMMUNE SYSTEM 01/21/26 L9 epitope scaffold complexed with L9 Fabs Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Raghavan, S.S.R., Lee, W.H., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dzf H L 0 B | A protein | protein NA | NA atrial natriuretic peptide receptor 1 | atrial natriuretic peptide receptor 1 MEMBRANE PROTEIN 01/21/26 Human GC-A bound to ANP and XX16 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Liu, S., Huang, X.-Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dzg H L 0 B | A protein | protein NA | NA atrial natriuretic peptide receptor 1 | atrial natriuretic peptide receptor 1 MEMBRANE PROTEIN 01/21/26 Human GC-A bound to XX16 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Liu, S., Huang, X.-Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dzh H L 0 B protein NA atrial natriuretic peptide receptor 1 MEMBRANE PROTEIN 01/21/26 Human GC-A bound to ANP and REGN5308 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Liu, S., Huang, X.-Y. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9dzj H L 0 B protein NA atrial natriuretic peptide receptor 1 MEMBRANE PROTEIN 01/21/26 Human GC-A bound to ANP and 2xREGN5308 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Liu, S., Huang, X.-Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9dzj G K 0 A protein NA atrial natriuretic peptide receptor 1 MEMBRANE PROTEIN 01/21/26 Human GC-A bound to ANP and 2xREGN5308 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Liu, S., Huang, X.-Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9dzk H L 0 B | A protein | protein NA | NA atrial natriuretic peptide receptor 1 | atrial natriuretic peptide receptor 1 MEMBRANE PROTEIN 01/21/26 Human GC-A bound to REGN5308 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Liu, S., Huang, X.-Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9e6j H L 0 A protein NA hemagglutinin VIRAL PROTEIN 01/21/26 DH726-1 Fab bound to hemagglutinin from influenza A/Solomon Islands/3/2006 Alphainfluenzavirus influenzae; Macaca mulatta macaca mulatta macaca mulatta alphainfluenzavirus influenzae Finney, J., Harrison, S.C. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9e6j I M 0 B protein NA hemagglutinin VIRAL PROTEIN 01/21/26 DH726-1 Fab bound to hemagglutinin from influenza A/Solomon Islands/3/2006 Alphainfluenzavirus influenzae; Macaca mulatta macaca mulatta macaca mulatta alphainfluenzavirus influenzae Finney, J., Harrison, S.C. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9e6j J N 0 C protein NA hemagglutinin VIRAL PROTEIN 01/21/26 DH726-1 Fab bound to hemagglutinin from influenza A/Solomon Islands/3/2006 Alphainfluenzavirus influenzae; Macaca mulatta macaca mulatta macaca mulatta alphainfluenzavirus influenzae Finney, J., Harrison, S.C. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9eb9 E NA 0 B protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody94 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eb9 F NA 0 C protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody94 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eb9 G NA 0 D protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody94 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eb9 H NA 0 A protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody94 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eba E NA 0 A protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody57 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Christensen, C.R., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eba F NA 0 B protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody57 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Christensen, C.R., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eba G NA 0 C protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody57 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Christensen, C.R., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eba H NA 0 D protein NA mucolipin-1 MEMBRANE PROTEIN 01/21/26 Human TRPML1 bound to Sybody57 Homo sapiens; synthetic construct synthetic construct homo sapiens Pumroy, R.P., Christensen, C.R., Salphati, S.P., Moiseenkova-Bell, V.Y., Newstead, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9j4c H L 0 A protein NA plexin-a1 PROTEIN BINDING/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of aPlexinA1-19-43 Fab in complex with PlexinA1 dimer Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Tian, H., Fung, C.P. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9lix NA D 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.0 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lix NA C 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.0 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lix NA E 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.0 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lix NA A 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.0 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lix NA F 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.0 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lix NA B 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.0 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9liy NA F 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9liy NA A 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9liy NA D 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9liy NA B 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9liy NA E 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9liy NA C 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 2) - polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lj0 NA C 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 3). Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.3 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lj0 NA A 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 3). Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.3 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lj0 NA B 0 NA NA NA NA PROTEIN FIBRIL 01/21/26 The cryo-EM structure of amyloid fibrils from abdominal fat of an AL amyloidosis patient (case 3). Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.3 ELECTRON MICROSCOPY NA NA False False NA IGLV1 Lambda None None None None None 9lly D I 0 A protein NA rsv pre-f protein VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of RSV pre-F (sc9-10 DS-Cav1, strain A2) in complex with Fabs 1A2 and 1B6 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Liu, L., Zheng, Q., Li, S. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9lly H L 0 A protein NA rsv pre-f protein VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of RSV pre-F (sc9-10 DS-Cav1, strain A2) in complex with Fabs 1A2 and 1B6 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Liu, L., Zheng, Q., Li, S. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9lly E K 0 B protein NA rsv pre-f protein VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of RSV pre-F (sc9-10 DS-Cav1, strain A2) in complex with Fabs 1A2 and 1B6 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Liu, L., Zheng, Q., Li, S. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9lly G N 0 B protein NA rsv pre-f protein VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of RSV pre-F (sc9-10 DS-Cav1, strain A2) in complex with Fabs 1A2 and 1B6 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Liu, L., Zheng, Q., Li, S. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9lly F M 0 C protein NA rsv pre-f protein VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of RSV pre-F (sc9-10 DS-Cav1, strain A2) in complex with Fabs 1A2 and 1B6 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Liu, L., Zheng, Q., Li, S. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9lly J O 0 C protein NA rsv pre-f protein VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of RSV pre-F (sc9-10 DS-Cav1, strain A2) in complex with Fabs 1A2 and 1B6 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Liu, L., Zheng, Q., Li, S. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9lm5 D NA 0 C protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1G9 Camelus bactrianus; Respiratory syncytial virus A2 camelus bactrianus respiratory syncytial virus a2 Wang, Q.Q., Ke, X.L., Li, E.T., Hong, D.X., Li, H.X., Cheng, Z.K., Zhang, J.C., Jin, T.C., Shu, B., Chiu, S. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lm5 E NA 0 A protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1G9 Camelus bactrianus; Respiratory syncytial virus A2 camelus bactrianus respiratory syncytial virus a2 Wang, Q.Q., Ke, X.L., Li, E.T., Hong, D.X., Li, H.X., Cheng, Z.K., Zhang, J.C., Jin, T.C., Shu, B., Chiu, S. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lm5 F NA 0 B protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1G9 Camelus bactrianus; Respiratory syncytial virus A2 camelus bactrianus respiratory syncytial virus a2 Wang, Q.Q., Ke, X.L., Li, E.T., Hong, D.X., Li, H.X., Cheng, Z.K., Zhang, J.C., Jin, T.C., Shu, B., Chiu, S. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lm6 D NA 0 A protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1D8 Camelus bactrianus; Respiratory syncytial virus A2 camelus bactrianus respiratory syncytial virus a2 Wang, Q.Q., Ke, X.L., Li, E.T., Hong, D.X., Li, H.X., Cheng, Z.K., Zhang, J.C., Jin, T.C., Shu, B., Chiu, S. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lm6 E NA 0 B protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1D8 Camelus bactrianus; Respiratory syncytial virus A2 camelus bactrianus respiratory syncytial virus a2 Wang, Q.Q., Ke, X.L., Li, E.T., Hong, D.X., Li, H.X., Cheng, Z.K., Zhang, J.C., Jin, T.C., Shu, B., Chiu, S. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lm6 F NA 0 C protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nanobody 1D8 Camelus bactrianus; Respiratory syncytial virus A2 camelus bactrianus respiratory syncytial virus a2 Wang, Q.Q., Ke, X.L., Li, E.T., Hong, D.X., Li, H.X., Cheng, Z.K., Zhang, J.C., Jin, T.C., Shu, B., Chiu, S. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lme C NA 0 B protein NA cd276 antigen IMMUNE SYSTEM 01/21/26 Checkpoint regulator protein in complex with a nanobody Homo sapiens; Lama glama lama glama homo sapiens Chen, W.M., Sahili, A., Yew, W.N., Lescar, J. 2.404 X-RAY DIFFRACTION 0.210 0.178 False True IGHV3 NA NA None None None None None 9lme F NA 0 A protein NA cd276 antigen IMMUNE SYSTEM 01/21/26 Checkpoint regulator protein in complex with a nanobody Homo sapiens; Lama glama lama glama homo sapiens Chen, W.M., Sahili, A., Yew, W.N., Lescar, J. 2.404 X-RAY DIFFRACTION 0.210 0.178 False True IGHV3 NA NA None None None None None 9mmj B A 0 D peptide NA surface protein gp120 jr-fl v3 peptide IMMUNE SYSTEM 01/21/26 Crystal Structure of 19b Fab bound to the third variable (V3) loop peptide from the HIV-1 JR-FL envelope (Env) glycoprotein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Fetics, S., Acharya, P. 1.78 X-RAY DIFFRACTION 0.199 0.159 False True IGHV3 IGKV1 Kappa None None None None None 9mpz H L 0 B | A | C protein | protein | protein NA | NA | NA capsid protein vp2 | capsid protein vp1 | capsid protein vp3 VIRUS/IMMUNE SYSTEM 01/21/26 Complex of FMDV Asia1/JS/05 and porcine-derived neutralizing monoclonal antibody PAS12 Foot-and-mouth disease virus Asia 1; Sus scrofa sus scrofa sus scrofa foot-and-mouth disease virus asia 1 | foot-and-mouth disease virus asia 1 | foot-and-mouth disease virus asia 1 Wu, S., Lei, D. 2.14 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9mz6 B A 0 D peptide NA 5768-p27 envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/21/26 Crystal Structure of 19b Fab bound to the third variable (V3) loop peptide from the HIV-1 5768-p27 envelope (Env) glycoprotein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Fetics, S., Acharya, P. 2.5 X-RAY DIFFRACTION 0.241 0.190 False True IGHV3 IGKV1 Kappa None None None None None 9mz7 B A 0 D peptide NA 92br020 envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/21/26 Crystal Structure of 19b Fab bound to the third variable (V3) loop peptide from the HIV-1 92BR020 envelope (Env) glycoprotein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Fetics, S., Acharya, P. 1.94 X-RAY DIFFRACTION 0.269 0.220 False True IGHV3 IGKV1 Kappa None None None None None 9mz8 B A 0 D peptide NA envelope glycoprotein 5768x-p27 IMMUNE SYSTEM/VIRAL PROTEIN 01/21/26 Crystal Structure of 19b Fab bound to the third variable (V3) loop peptide from the HIV-1 5768x-p27 envelope (Env) glycoprotein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Fetics, S., Acharya, P. 1.74 X-RAY DIFFRACTION 0.226 0.190 False True IGHV3 IGKV1 Kappa None None None None None 9mz9 B A 0 NA NA NA NA IMMUNE SYSTEM 01/21/26 Crystal Structure of 19b Fab Homo sapiens homo sapiens homo sapiens Fetics, S., Acharya, P. 2.1 X-RAY DIFFRACTION 0.248 0.216 False True IGHV3 IGKV1 Kappa None None None None None 9nsd E NA 0 A protein NA cysteine-rich small secreted protein css, putative CELL INVASION 01/21/26 Crystal structure of PvCSS-PvPTRAMP in complex with nanobody D7 Plasmodium vivax; Vicugna pacos vicugna pacos plasmodium vivax Seager, B.A., Scally, S.W., Cowman, A.F. 3.14 X-RAY DIFFRACTION 0.273 0.225 False True IGHV3 NA NA None None None None None 9nsd C NA 0 B protein NA cysteine-rich small secreted protein css, putative CELL INVASION 01/21/26 Crystal structure of PvCSS-PvPTRAMP in complex with nanobody D7 Plasmodium vivax; Vicugna pacos vicugna pacos plasmodium vivax Seager, B.A., Scally, S.W., Cowman, A.F. 3.14 X-RAY DIFFRACTION 0.273 0.225 False True IGHV3 NA NA None None None None None 9nsd F NA 0 D protein NA cysteine-rich small secreted protein css, putative CELL INVASION 01/21/26 Crystal structure of PvCSS-PvPTRAMP in complex with nanobody D7 Plasmodium vivax; Vicugna pacos vicugna pacos plasmodium vivax Seager, B.A., Scally, S.W., Cowman, A.F. 3.14 X-RAY DIFFRACTION 0.273 0.225 False True IGHV3 NA NA None None None None None 9o3d A B 0 D protein NA envelope glycoprotein e2 IMMUNE SYSTEM 01/21/26 Crystal structure of broadly neutralizing antibody HEPC108 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepatitis C virus subtype 1b; Homo sapiens homo sapiens homo sapiens hepatitis c virus subtype 1b Flyak, A.I., Wilcox, X.E. 2.68 X-RAY DIFFRACTION 0.269 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9o3d E F 0 G protein NA envelope glycoprotein e2 IMMUNE SYSTEM 01/21/26 Crystal structure of broadly neutralizing antibody HEPC108 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepatitis C virus subtype 1b; Homo sapiens homo sapiens homo sapiens hepatitis c virus subtype 1b Flyak, A.I., Wilcox, X.E. 2.68 X-RAY DIFFRACTION 0.269 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9o3d H L 0 C protein NA envelope glycoprotein e2 IMMUNE SYSTEM 01/21/26 Crystal structure of broadly neutralizing antibody HEPC108 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepatitis C virus subtype 1b; Homo sapiens homo sapiens homo sapiens hepatitis c virus subtype 1b Flyak, A.I., Wilcox, X.E. 2.68 X-RAY DIFFRACTION 0.269 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9o3d I J 0 K protein NA envelope glycoprotein e2 IMMUNE SYSTEM 01/21/26 Crystal structure of broadly neutralizing antibody HEPC108 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepatitis C virus subtype 1b; Homo sapiens homo sapiens homo sapiens hepatitis c virus subtype 1b Flyak, A.I., Wilcox, X.E. 2.68 X-RAY DIFFRACTION 0.269 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9obn E NA 0 B protein NA gametocyte surface protein p45/48 PROTEIN BINDING 01/21/26 Crystal structure of malaria transmission-blocking antigen Pfs48/45 C-terminal domain in complex with nanobody B2 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Lyons, F.M.T., Dietrich, M.H., Tham, W.H. 2.5 X-RAY DIFFRACTION 0.254 0.208 False True IGHV1 NA NA None None None None None 9obn H NA 0 D protein NA gametocyte surface protein p45/48 PROTEIN BINDING 01/21/26 Crystal structure of malaria transmission-blocking antigen Pfs48/45 C-terminal domain in complex with nanobody B2 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Lyons, F.M.T., Dietrich, M.H., Tham, W.H. 2.5 X-RAY DIFFRACTION 0.254 0.208 False True IGHV1 NA NA None None None None None 9obn G NA 0 A protein NA gametocyte surface protein p45/48 PROTEIN BINDING 01/21/26 Crystal structure of malaria transmission-blocking antigen Pfs48/45 C-terminal domain in complex with nanobody B2 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Lyons, F.M.T., Dietrich, M.H., Tham, W.H. 2.5 X-RAY DIFFRACTION 0.254 0.208 False True IGHV1 NA NA None None None None None 9obn F NA 0 C protein NA gametocyte surface protein p45/48 PROTEIN BINDING 01/21/26 Crystal structure of malaria transmission-blocking antigen Pfs48/45 C-terminal domain in complex with nanobody B2 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Lyons, F.M.T., Dietrich, M.H., Tham, W.H. 2.5 X-RAY DIFFRACTION 0.254 0.208 False True IGHV1 NA NA None None None None None 9p6x D NA 0 B protein NA envelope glycoprotein VIRAL PROTEIN 01/21/26 Structure of EBOV glycoprotein in complex with Nanosota-EB1 and EB2 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Li, F. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9p6x E NA 0 A protein NA envelope glycoprotein VIRAL PROTEIN 01/21/26 Structure of EBOV glycoprotein in complex with Nanosota-EB1 and EB2 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Li, F. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9p6x F NA 0 C protein NA envelope glycoprotein VIRAL PROTEIN 01/21/26 Structure of EBOV glycoprotein in complex with Nanosota-EB1 and EB2 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Li, F. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9p6x G NA 0 C protein NA envelope glycoprotein VIRAL PROTEIN 01/21/26 Structure of EBOV glycoprotein in complex with Nanosota-EB1 and EB2 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Li, F. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9p6x H NA 0 A protein NA envelope glycoprotein VIRAL PROTEIN 01/21/26 Structure of EBOV glycoprotein in complex with Nanosota-EB1 and EB2 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Li, F. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9p6x I NA 0 B protein NA envelope glycoprotein VIRAL PROTEIN 01/21/26 Structure of EBOV glycoprotein in complex with Nanosota-EB1 and EB2 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Li, F. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9q1l A B 0 C peptide NA vicilin jug r 2.0102 hairpinin alpha 4 ALLERGEN/IMMUNE SYSTEM 01/21/26 Crystal structure of the walnut allergen Jug r 2 bound to the human-derived Fab 6D12 Homo sapiens; Juglans regia homo sapiens homo sapiens juglans regia Pedersen, L.C., Lytle, I.R., Mueller, G.A., Croote, D.C. 1.56 X-RAY DIFFRACTION 0.195 0.168 False True IGHV4 IGKV1 Kappa None None None None None 9q1l D E 0 F peptide NA vicilin jug r 2.0102 hairpinin alpha 4 ALLERGEN/IMMUNE SYSTEM 01/21/26 Crystal structure of the walnut allergen Jug r 2 bound to the human-derived Fab 6D12 Homo sapiens; Juglans regia homo sapiens homo sapiens juglans regia Pedersen, L.C., Lytle, I.R., Mueller, G.A., Croote, D.C. 1.56 X-RAY DIFFRACTION 0.195 0.168 False True IGHV4 IGKV1 Kappa None None None None None 9rn6 B NA 0 A protein NA spike protein s2',chimeric protein mimic of sars-cov-2spike hr1 VIRAL PROTEIN 01/21/26 Crystal structure of a protein mimic of SARS-CoV-2 spike's HR1 domain in complex with two nanobodies bound to different epitopes Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Camara-Artigas, A., Conejero-Lara, F., Polo-Megias, D., Salinas-Garcia, M.C., Gavira, J.A. 2.4 X-RAY DIFFRACTION 0.263 0.247 False True IGHV1 NA NA None None None None None 9rn6 C NA 0 A protein NA spike protein s2',chimeric protein mimic of sars-cov-2spike hr1 VIRAL PROTEIN 01/21/26 Crystal structure of a protein mimic of SARS-CoV-2 spike's HR1 domain in complex with two nanobodies bound to different epitopes Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Camara-Artigas, A., Conejero-Lara, F., Polo-Megias, D., Salinas-Garcia, M.C., Gavira, J.A. 2.4 X-RAY DIFFRACTION 0.263 0.247 False True IGHV1 NA NA None None None None None 9up7 A B 0 NA NA NA NA IMMUNE SYSTEM 01/21/26 anti-HPV18 E7 monoclonal antibody Mus musculus mus musculus mus musculus Feng, H., Tingting, L., Ying, G., Shaowei, L. 2.1 X-RAY DIFFRACTION 0.257 0.211 True False IGHV1 IGKV8 Kappa None None None None None 9up7 H L 0 NA NA NA NA IMMUNE SYSTEM 01/21/26 anti-HPV18 E7 monoclonal antibody Mus musculus mus musculus mus musculus Feng, H., Tingting, L., Ying, G., Shaowei, L. 2.1 X-RAY DIFFRACTION 0.257 0.211 True False IGHV1 IGKV8 Kappa None None None None None 9uv4 I M 0 A protein NA mhv 68 glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Structure of MHV68 glycoprotein B in complex with Fab5 Murid herpesvirus 68; Mus musculus mus musculus mus musculus murid herpesvirus 68 Cheng, B.Z., Xie, C., Sun, C., Zeng, M.S., Liu, Z., Fang, X.Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9uv4 J N 0 B protein NA mhv 68 glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Structure of MHV68 glycoprotein B in complex with Fab5 Murid herpesvirus 68; Mus musculus mus musculus mus musculus murid herpesvirus 68 Cheng, B.Z., Xie, C., Sun, C., Zeng, M.S., Liu, Z., Fang, X.Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9uv4 K O 0 C protein NA mhv 68 glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Structure of MHV68 glycoprotein B in complex with Fab5 Murid herpesvirus 68; Mus musculus mus musculus mus musculus murid herpesvirus 68 Cheng, B.Z., Xie, C., Sun, C., Zeng, M.S., Liu, Z., Fang, X.Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9uy9 H L 0 C protein NA macacine gammaherpesvirus 4 glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Macacine gammaherpesvirus 4 glycoprotein B in complex with Fab5 Macacine gammaherpesvirus 4; Mus musculus mus musculus mus musculus macacine gammaherpesvirus 4 Cheng, B.Z., Liu, Z. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9uy9 I M 0 B protein NA macacine gammaherpesvirus 4 glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Macacine gammaherpesvirus 4 glycoprotein B in complex with Fab5 Macacine gammaherpesvirus 4; Mus musculus mus musculus mus musculus macacine gammaherpesvirus 4 Cheng, B.Z., Liu, Z. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9uy9 J N 0 A protein NA macacine gammaherpesvirus 4 glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/21/26 Macacine gammaherpesvirus 4 glycoprotein B in complex with Fab5 Macacine gammaherpesvirus 4; Mus musculus mus musculus mus musculus macacine gammaherpesvirus 4 Cheng, B.Z., Liu, Z. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9ntt B NA 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 T-cell engager for the treatment of GPC3+ solid tumors Homo sapiens; Lama glama lama glama Batchelor, J.D., Svidritskiy, E. 7.45 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9cm4 H L 0 J nucleic-acid NA hcv2 rna loop RNA binding protein/RNA 01/14/26 HCV2 Fab bound to selected RNA loop Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Disare, M.T., Lewicka, A., Piccirilli, J.A. 1.82 X-RAY DIFFRACTION 0.198 0.160 False True IGHV3 IGKV1 Kappa None None None None None 9cm4 A B 0 G nucleic-acid NA hcv2 rna loop RNA binding protein/RNA 01/14/26 HCV2 Fab bound to selected RNA loop Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Disare, M.T., Lewicka, A., Piccirilli, J.A. 1.82 X-RAY DIFFRACTION 0.198 0.160 False True IGHV3 IGKV1 Kappa None None None None None 9fte B NA 0 A protein NA adhesion g protein-coupled receptor v1 MEMBRANE PROTEIN 01/14/26 Cryo-EM structure of the adhesion GPCR ADGRV1 in complex with a nanobody Mus musculus; Vicugna pacos vicugna pacos mus musculus Achat, Y., Prevost, M., Mechaly, A., Genera, M., Colcombet, J.B., Bezault, A., Winter, J.M., Ayme, G., Venien-Bryan, C., Wolff, N. 3.82 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9gvn C D 0 B protein NA interleukin-5 IMMUNE SYSTEM 01/14/26 DEPEMOKIMAB FAB IN COMPLEX WITH INTERLEUKIN 5 Homo sapiens homo sapiens homo sapiens homo sapiens Somers, D.O. 1.933 X-RAY DIFFRACTION 0.209 0.183 False True IGHV2 IGKV4 Kappa None None None None None 9gvn E F 0 A protein NA interleukin-5 IMMUNE SYSTEM 01/14/26 DEPEMOKIMAB FAB IN COMPLEX WITH INTERLEUKIN 5 Homo sapiens homo sapiens homo sapiens homo sapiens Somers, D.O. 1.933 X-RAY DIFFRACTION 0.209 0.183 False True IGHV2 IGKV4 Kappa None None None None None 9hum P NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein | gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 01/14/26 a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after short GABA treatment Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens, aequorea victoria | homo sapiens, aequorea victoria Cowgill, J., Fan, C., Howard, R.J., Lindahl, E. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hv1 H L 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Crystal structure of tri-specific FMDV mAb-17 Fab Bos taurus bos taurus bos taurus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 1.96 X-RAY DIFFRACTION 0.236 0.212 False True IGHV1 IGLV3 Lambda None None None None None 9hv2 A B 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Crystal structure of tri-specific FMDV mAb-34 Fab Bos taurus bos taurus bos taurus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 1.77 X-RAY DIFFRACTION 0.235 0.208 False True IGHV1 IGLV3 Lambda None None None None None 9hv2 H L 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Crystal structure of tri-specific FMDV mAb-34 Fab Bos taurus bos taurus bos taurus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 1.77 X-RAY DIFFRACTION 0.235 0.208 False True IGHV1 IGLV3 Lambda None None None None None 9hv8 H L 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Crystal structure of tri-specific FMDV mAb-49 Fab Bos taurus bos taurus bos taurus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 1.72 X-RAY DIFFRACTION 0.211 0.183 False True IGHV1 IGLV3 Lambda None None None None None 9hv9 H L 0 A peptide NA capsid protein vp1 IMMUNE SYSTEM 01/14/26 Crystal structure of Fab34 complexed with a 7-mer peptide of FMDV VP1 Bos taurus; SYNTHETIC CONSTRUCT bos taurus bos taurus foot-and-mouth disease virus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 1.8 X-RAY DIFFRACTION 0.229 0.201 False True IGHV1 IGLV3 Lambda None None None None None 9hva H L 0 A peptide NA capsid protein vp1 IMMUNE SYSTEM 01/14/26 Crystal structure of Fab34 complexed with a 18-mer peptide of FMDV VP1 Bos taurus; SYNTHETIC CONSTRUCT bos taurus bos taurus foot-and-mouth disease virus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 3.89 X-RAY DIFFRACTION 0.279 0.233 False True IGHV1 IGLV3 Lambda None None None None None 9hva B C 0 D peptide NA capsid protein vp1 IMMUNE SYSTEM 01/14/26 Crystal structure of Fab34 complexed with a 18-mer peptide of FMDV VP1 Bos taurus; SYNTHETIC CONSTRUCT bos taurus bos taurus foot-and-mouth disease virus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 3.89 X-RAY DIFFRACTION 0.279 0.233 False True IGHV1 IGLV3 Lambda None None None None None 9hva E F 0 G peptide NA capsid protein vp1 IMMUNE SYSTEM 01/14/26 Crystal structure of Fab34 complexed with a 18-mer peptide of FMDV VP1 Bos taurus; SYNTHETIC CONSTRUCT bos taurus bos taurus foot-and-mouth disease virus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 3.89 X-RAY DIFFRACTION 0.279 0.233 False True IGHV1 IGLV3 Lambda None None None None None 9hva I J 0 K peptide NA capsid protein vp1 IMMUNE SYSTEM 01/14/26 Crystal structure of Fab34 complexed with a 18-mer peptide of FMDV VP1 Bos taurus; SYNTHETIC CONSTRUCT bos taurus bos taurus foot-and-mouth disease virus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 3.89 X-RAY DIFFRACTION 0.279 0.233 False True IGHV1 IGLV3 Lambda None None None None None 9hva M N 0 O peptide NA capsid protein vp1 IMMUNE SYSTEM 01/14/26 Crystal structure of Fab34 complexed with a 18-mer peptide of FMDV VP1 Bos taurus; SYNTHETIC CONSTRUCT bos taurus bos taurus foot-and-mouth disease virus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 3.89 X-RAY DIFFRACTION 0.279 0.233 False True IGHV1 IGLV3 Lambda None None None None None 9hva P Q 0 R peptide NA capsid protein vp1 IMMUNE SYSTEM 01/14/26 Crystal structure of Fab34 complexed with a 18-mer peptide of FMDV VP1 Bos taurus; SYNTHETIC CONSTRUCT bos taurus bos taurus foot-and-mouth disease virus Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 3.89 X-RAY DIFFRACTION 0.279 0.233 False True IGHV1 IGLV3 Lambda None None None None None 9l9y H L 0 C protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Immune complex of HEV E2s and mAb 6H8 Hepatitis E virus; Mus musculus mus musculus mus musculus hepatitis e virus Zimin, T., Guiping, W., Hai, Y., Qing, Z., Zizheng, Z., Ningshao, X., Shaowei, L. 2.44 X-RAY DIFFRACTION 0.236 0.216 False False IGHV1 IGKV4 Kappa None None None None None 9l9y A B 0 D protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Immune complex of HEV E2s and mAb 6H8 Hepatitis E virus; Mus musculus mus musculus mus musculus hepatitis e virus Zimin, T., Guiping, W., Hai, Y., Qing, Z., Zizheng, Z., Ningshao, X., Shaowei, L. 2.44 X-RAY DIFFRACTION 0.236 0.216 False False IGHV1 IGKV4 Kappa None None None None None 9l9z H L 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Fab of anti-HEV mAb 6H8 Mus musculus mus musculus mus musculus Zimin, T., Guiping, W., Hai, Y., Qing, Z., Zizheng, Z., Ningshao, X., Shaowei, L. 1.5 X-RAY DIFFRACTION 0.210 0.182 False False IGHV1 IGKV4 Kappa None None None None None 9lh2 B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 01/14/26 Crystal structure of SARS-CoV-2 spike receptor-binding domain (Delta) in complex with pH-dependent nanobody MNb-11. Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Zhang, X.D., Lu, G.W. 2.3 X-RAY DIFFRACTION 0.236 0.209 False True IGHV3 NA NA None None None None None 9lh2 D NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 01/14/26 Crystal structure of SARS-CoV-2 spike receptor-binding domain (Delta) in complex with pH-dependent nanobody MNb-11. Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Zhang, X.D., Lu, G.W. 2.3 X-RAY DIFFRACTION 0.236 0.209 False True IGHV3 NA NA None None None None None 9mnq H L 0 E protein NA hepatitis c virus envelope glycoprotein e2 core fromgenotype 6a VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C virus envelope glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM10-30 Macaca mulatta; Recombinant Hepatitis C virus HK6a/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Nguyen, T.K.Y., Wilson, I.A. 2.83 X-RAY DIFFRACTION 0.287 0.258 False True IGHV1 IGKV1 Kappa None None None None None 9mns H L 0 E protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C virus envelope glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM1-36 Macaca mulatta; Recombinant Hepatitis C virus HK6a/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 2.89 X-RAY DIFFRACTION 0.250 0.232 False True IGHV1 IGKV1 Kappa None None None None None 9mns h l 0 B protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C virus envelope glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM1-36 Macaca mulatta; Recombinant Hepatitis C virus HK6a/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 2.89 X-RAY DIFFRACTION 0.250 0.232 False False IGHV1 IGKV1 Kappa None None None None None 9mnt H L 0 E protein NA hepatitis c virus envelope glycoprotein e2 core fromgenotype 6a VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C virus envelope glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM1-73 Macaca mulatta; Recombinant Hepatitis C virus HK6a/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 2.55 X-RAY DIFFRACTION 0.252 0.231 False True IGHV1 IGKV1 Kappa None None None None None 9mnu H L 0 E protein NA hepatitis c virus envelope glycoprotein e2 core fromgenotype 6a VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C virus envelope glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM11-48 Macaca mulatta; Recombinant Hepatitis C virus HK6a/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 2.85 X-RAY DIFFRACTION 0.275 0.240 False True IGHV1 IGKV7 Kappa None None None None None 9mnu h l 0 e protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C virus envelope glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM11-48 Macaca mulatta; Recombinant Hepatitis C virus HK6a/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 2.85 X-RAY DIFFRACTION 0.275 0.240 False False IGHV1 IGKV7 Kappa None None None None None 9mqo B C 0 A peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/14/26 Crystal structure of BCMA in complex with CA10v2 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Qiu, Y. 3.181 X-RAY DIFFRACTION 0.272 0.232 False True IGHV3 IGLV7 Lambda None None None None None 9mqo E F 0 D peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/14/26 Crystal structure of BCMA in complex with CA10v2 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Qiu, Y. 3.181 X-RAY DIFFRACTION 0.272 0.232 False True IGHV3 IGLV7 Lambda None None None None None 9mqo H I 0 G peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/14/26 Crystal structure of BCMA in complex with CA10v2 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Qiu, Y. 3.181 X-RAY DIFFRACTION 0.272 0.232 False True IGHV3 IGLV7 Lambda None None None None None 9mqo K L 0 J peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/14/26 Crystal structure of BCMA in complex with CA10v2 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Qiu, Y. 3.181 X-RAY DIFFRACTION 0.272 0.232 False True IGHV3 IGLV7 Lambda None None None None None 9mqo N O 0 M peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/14/26 Crystal structure of BCMA in complex with CA10v2 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Qiu, Y. 3.181 X-RAY DIFFRACTION 0.272 0.232 False True IGHV3 IGLV7 Lambda None None None None None 9mqo Q R 0 P peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/14/26 Crystal structure of BCMA in complex with CA10v2 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Qiu, Y. 3.181 X-RAY DIFFRACTION 0.272 0.232 False True IGHV3 IGLV7 Lambda None None None None None 9mrz h l 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Structure of HCV broadly neutralizing antibody RM1-73 Macaca mulatta macaca mulatta macaca mulatta Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 2.03 X-RAY DIFFRACTION 0.196 0.170 False False IGHV1 IGKV1 Kappa None None None None None 9mrz H L 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Structure of HCV broadly neutralizing antibody RM1-73 Macaca mulatta macaca mulatta macaca mulatta Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 2.03 X-RAY DIFFRACTION 0.196 0.170 False True IGHV1 IGKV1 Kappa None None None None None 9ms9 H L 0 NA NA NA NA IMMUNE SYSTEM 01/14/26 Structure of HCV neutralizing antibody RM5-16 Macaca mulatta macaca mulatta macaca mulatta Nguyen, T.K.Y., Wilson, I.A. 1.46 X-RAY DIFFRACTION 0.175 0.143 False True IGHV4 IGLV1 Lambda None None None None None 9msc H L 0 E protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C Virus Envelope Glycoprotein HCV-1 E2ecto from genotype 1a bound to neutralizing antibody RM5-16 Hepatitis C virus (isolate 1); Homo sapiens; Macaca mulatta macaca mulatta macaca mulatta hepatitis c virus (isolate 1) Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 3.39 X-RAY DIFFRACTION 0.317 0.278 False True IGHV4 IGLV1 Lambda None None None None None 9msc A B 0 E protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 01/14/26 Structure of Hepatitis C Virus Envelope Glycoprotein HCV-1 E2ecto from genotype 1a bound to neutralizing antibody RM5-16 Hepatitis C virus (isolate 1); Homo sapiens; Macaca mulatta homo sapiens homo sapiens hepatitis c virus (isolate 1) Nguyen, T.K.Y., Stanfield, R.L., Wilson, I.A. 3.39 X-RAY DIFFRACTION 0.317 0.278 False True IGHV1 IGLV1 Lambda None None None None None 9r6h A NA 0 NA NA NA NA CELL CYCLE 01/14/26 Crystal Structure of the M18BP1 SANTA domain as a EGFP-SANTA-nanobody fusion Homo sapiens homo sapiens Pan, D., Vetter, I.R., Musacchio, A. 2.42 X-RAY DIFFRACTION 0.262 0.229 False True IGHV1 NA NA None None None None None 9r6h B NA 0 NA NA NA NA CELL CYCLE 01/14/26 Crystal Structure of the M18BP1 SANTA domain as a EGFP-SANTA-nanobody fusion Homo sapiens homo sapiens Pan, D., Vetter, I.R., Musacchio, A. 2.42 X-RAY DIFFRACTION 0.262 0.229 False True IGHV1 NA NA None None None None None 9tgn B A 0 M nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z-DNA binding antibody Z-D11 in complex with left-handed Z-DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgn D C 0 P nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z-DNA binding antibody Z-D11 in complex with left-handed Z-DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgn F E 0 N nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z-DNA binding antibody Z-D11 in complex with left-handed Z-DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgn H G 0 M nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z-DNA binding antibody Z-D11 in complex with left-handed Z-DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgn J I 0 O nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z-DNA binding antibody Z-D11 in complex with left-handed Z-DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgn L K 0 O nucleic-acid NA dna (5'-d(*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z-DNA binding antibody Z-D11 in complex with left-handed Z-DNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgo A B 0 P nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 mAb in complex with left-handed Z-DNA (dimer of trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgo C E 0 P nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 mAb in complex with left-handed Z-DNA (dimer of trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgo D F 0 O nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 mAb in complex with left-handed Z-DNA (dimer of trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgo I J 0 T nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 mAb in complex with left-handed Z-DNA (dimer of trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgo K M 0 T nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 mAb in complex with left-handed Z-DNA (dimer of trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgo L N 0 S nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 mAb in complex with left-handed Z-DNA (dimer of trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgw A B 0 P nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 antibody in complex with left-handed Z-DNA (trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgw C E 0 P nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 antibody in complex with left-handed Z-DNA (trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9tgw D F 0 O nucleic-acid NA dna (5'-d(p*cp*gp*cp*gp*cp*gp*cp*gp*cp*gp*cp*g)-3') DNA BINDING PROTEIN 01/14/26 Cryo-EM structure of Z22 antibody in complex with left-handed Z-DNA (trimer) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chin, D.H.R., Luo, Y.B., Luo, D. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 9k6j A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 Crystal structure of SARS-CoV-2 WT RBD bound with P5-1C8 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lv, N.N., Yang, R.Y. 2.39 X-RAY DIFFRACTION 0.283 0.236 False True IGHV3 IGKV3 Kappa None None None None None 9lbw H L 0 B | A protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 HBcAg in complex with Fab mAb40 Hepatitis B virus; Homo sapiens homo sapiens homo sapiens hepatitis b virus | hepatitis b virus Chen, S.L. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9lja NA B 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.1 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9lja NA A 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.1 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9lja NA C 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 1. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.1 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9ljb NA A 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9ljb NA B 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9ljb NA C 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9ljb NA F 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9ljb NA D 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9ljb NA E 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 1)- polymorph 2. Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 3.2 ELECTRON MICROSCOPY NA NA False False NA IGLV2 Lambda None None None None None 9ljc NA A 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 2). Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 2.7 ELECTRON MICROSCOPY NA NA False False NA IGLV6 Lambda None None None None None 9ljc NA B 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 2). Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 2.7 ELECTRON MICROSCOPY NA NA False False NA IGLV6 Lambda None None None None None 9ljc NA C 0 NA NA NA NA PROTEIN FIBRIL 01/07/26 The cryo-EM structure of amyloid fibrils from abdominal fat of a multiple myeloma patient (case 2). Homo sapiens homo sapiens Yao, Y.X., Zhao, Q.Y., Liu, C., Li, D. 2.7 ELECTRON MICROSCOPY NA NA False False NA IGLV6 Lambda None None None None None 9ls3 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 S-ECD of SARS-CoV-2 Delta variant in complex with Fab854 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Y.N., Yan, R.H., Ju, B., Zhang, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9ls3 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 S-ECD of SARS-CoV-2 Delta variant in complex with Fab854 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Y.N., Yan, R.H., Ju, B., Zhang, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9ls3 H I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 S-ECD of SARS-CoV-2 Delta variant in complex with Fab854 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Y.N., Yan, R.H., Ju, B., Zhang, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9ua5 G K 0 C protein NA glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 RABV G binding with CTB011 Fab and CTB012 Fab Lyssavirus rabies; Mus musculus mus musculus mus musculus lyssavirus rabies Cao, L., Zhang, C. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ua5 H D 0 C protein NA glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 RABV G binding with CTB011 Fab and CTB012 Fab Lyssavirus rabies; Mus musculus mus musculus mus musculus lyssavirus rabies Cao, L., Zhang, C. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9vdy C D 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 hA5-6 Fab bound to SFTSV glycoprotein Gn Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Deng, Z., Kuang, W., Zhao, H. 2.28 X-RAY DIFFRACTION 0.240 0.204 False True IGHV1 IGKV3 Kappa None None None None None 9vdy H L 0 B protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 hA5-6 Fab bound to SFTSV glycoprotein Gn Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Deng, Z., Kuang, W., Zhao, H. 2.28 X-RAY DIFFRACTION 0.240 0.204 False True IGHV1 IGKV3 Kappa None None None None None 9vdz A B 0 C protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 hA5-6(W30B/E45) Fab bound to SFTSV glycoprotein Gn Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Deng, Z., Kuang, W., Zhao, H. 2.43 X-RAY DIFFRACTION 0.256 0.202 False True IGHV1 IGKV3 Kappa None None None None None 9vdz H L 0 D protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 hA5-6(W30B/E45) Fab bound to SFTSV glycoprotein Gn Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Deng, Z., Kuang, W., Zhao, H. 2.43 X-RAY DIFFRACTION 0.256 0.202 False True IGHV1 IGKV3 Kappa None None None None None 9ve0 H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/07/26 hA5-6 (W30B/W53) Fab bound to SFTSV glycoprotein Gn Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Deng, Z., Kuang, W., Zhao, H. 2.68 X-RAY DIFFRACTION 0.288 0.231 False True IGHV1 IGKV3 Kappa None None None None None 9xqb A B 0 C protein NA a2a receptor-bril MEMBRANE PROTEIN 01/07/26 Cryo-EM structure of the human A2A adenosine receptor in complex with a Fab antibody fragment Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Miyashita, Y., Konno, R., Ogasawara, S., Okuda, Y., Takamuku, Y., Moriya, T., Saito, T., Murata, T., Ohara, O., Kawashima, Y. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV5 Kappa None None None None None 9l79 S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 12/31/25 Structure of GPR119-Gs complex bound to AR231453 Bos taurus; Homo sapiens; Lama glama; Mus musculus; Rattus norvegicus mus musculus homo sapiens Sun, Q., He, G., Xu, X., Liu, X. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9l79 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 12/31/25 Structure of GPR119-Gs complex bound to AR231453 Bos taurus; Homo sapiens; Lama glama; Mus musculus; Rattus norvegicus lama glama homo sapiens | rattus norvegicus | bos taurus Sun, Q., He, G., Xu, X., Liu, X. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9l80 S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 12/31/25 Structure of GPR119-Gs complex bound to an allosteric modulator Bos taurus; Homo sapiens; Lama glama; Mus musculus; Rattus norvegicus mus musculus homo sapiens Sun, Q., He, G., Xu, X., Liu, X. 3.33 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9l80 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/31/25 Structure of GPR119-Gs complex bound to an allosteric modulator Bos taurus; Homo sapiens; Lama glama; Mus musculus; Rattus norvegicus lama glama homo sapiens | rattus norvegicus Sun, Q., He, G., Xu, X., Liu, X. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9vor C NA 0 B protein NA metabotropic glycine receptor MEMBRANE PROTEIN 12/31/25 Cryo-EM Structure of Human GPR158 Bound to Nanobody Nb20 Homo sapiens; Lama glama lama glama homo sapiens Laboute, T., Zucca, S., Sial, M., Sharma, M., Brunori, G., Singh, S., Singh, A., Martemyanov, K. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9vor E NA 0 A protein NA metabotropic glycine receptor MEMBRANE PROTEIN 12/31/25 Cryo-EM Structure of Human GPR158 Bound to Nanobody Nb20 Homo sapiens; Lama glama lama glama homo sapiens Laboute, T., Zucca, S., Sial, M., Sharma, M., Brunori, G., Singh, S., Singh, A., Martemyanov, K. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9l84 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/31/25 Structure of beta1-AR-Gs complex bound to epinephrine and an allosteric modulator Bos taurus; Homo sapiens; Lama glama; Rattus norvegicus lama glama bos taurus | rattus norvegicus Sun, Q., He, G., Xu, X., Liu, X. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9npt G NA 0 A protein NA envelope glycoprotein gp1 VIRAL PROTEIN 12/31/25 RAVV GP in complex with Nanosota-MB1 Ravn virus - Ravn, Kenya, 1987; Vicugna pacos vicugna pacos ravn virus - ravn, kenya, 1987 Ye, G., Bu, F., Liu, B., Li, F. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9npt H NA 0 C protein NA envelope glycoprotein gp1 VIRAL PROTEIN 12/31/25 RAVV GP in complex with Nanosota-MB1 Ravn virus - Ravn, Kenya, 1987; Vicugna pacos vicugna pacos ravn virus - ravn, kenya, 1987 Ye, G., Bu, F., Liu, B., Li, F. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9npt I NA 0 E protein NA envelope glycoprotein gp1 VIRAL PROTEIN 12/31/25 RAVV GP in complex with Nanosota-MB1 Ravn virus - Ravn, Kenya, 1987; Vicugna pacos vicugna pacos ravn virus - ravn, kenya, 1987 Ye, G., Bu, F., Liu, B., Li, F. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9p8x H L 0 A protein NA tumor necrosis factor receptor superfamily member 18 IMMUNE SYSTEM 12/31/25 Crystal structure of GITR in complex with ligand-non-competitive Ab#1 Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens Huang, C.-S., Mosyak, L., Maben, Z. 2.86 X-RAY DIFFRACTION 0.257 0.214 False True IGHV1 IGKV4 Kappa None None None None None 9pru B A 0 W protein NA low affinity immunoglobulin gamma fc region receptor iii-a IMMUNE SYSTEM 12/31/25 Complex of the 3G8 Fab bound to Fc gamma receptor 3a / CD16a F158 allotype Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Barb, A.W., Lanzilotta, W.N., Kremer, P.G. 1.9 X-RAY DIFFRACTION 0.280 0.230 False True IGHV8 IGKV3 Kappa None None None None None 9pru D C 0 X protein NA low affinity immunoglobulin gamma fc region receptor iii-a IMMUNE SYSTEM 12/31/25 Complex of the 3G8 Fab bound to Fc gamma receptor 3a / CD16a F158 allotype Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Barb, A.W., Lanzilotta, W.N., Kremer, P.G. 1.9 X-RAY DIFFRACTION 0.280 0.230 False True IGHV8 IGKV3 Kappa None None None None None 9pru F E 0 Y protein NA low affinity immunoglobulin gamma fc region receptor iii-a IMMUNE SYSTEM 12/31/25 Complex of the 3G8 Fab bound to Fc gamma receptor 3a / CD16a F158 allotype Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Barb, A.W., Lanzilotta, W.N., Kremer, P.G. 1.9 X-RAY DIFFRACTION 0.280 0.230 False True IGHV8 IGKV3 Kappa None None None None None 9pru H G 0 Z protein NA low affinity immunoglobulin gamma fc region receptor iii-a IMMUNE SYSTEM 12/31/25 Complex of the 3G8 Fab bound to Fc gamma receptor 3a / CD16a F158 allotype Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Barb, A.W., Lanzilotta, W.N., Kremer, P.G. 1.9 X-RAY DIFFRACTION 0.280 0.230 False True IGHV8 IGKV3 Kappa None None None None None 9uza H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Crimean-Congo hemorrhagic fever virus cap-snatching endonuclease Mus musculus; Orthonairovirus haemorrhagiae mus musculus mus musculus orthonairovirus haemorrhagiae Deng, Z., Kuang, W., Tian, Z. 3.05 X-RAY DIFFRACTION 0.295 0.226 False True IGHV14 IGKV1 Kappa None None None None None 9uza C D 0 B protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Crimean-Congo hemorrhagic fever virus cap-snatching endonuclease Mus musculus; Orthonairovirus haemorrhagiae mus musculus mus musculus orthonairovirus haemorrhagiae Deng, Z., Kuang, W., Tian, Z. 3.05 X-RAY DIFFRACTION 0.295 0.226 False True IGHV14 IGKV1 Kappa None None None None None 9uzb H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap-snatching endonuclease in apo form Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 1.9 X-RAY DIFFRACTION 0.221 0.182 False True IGHV5 IGKV1 Kappa None None None None None 9uzc H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap- snatching endonuclease in complex with manganese ions Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 1.98 X-RAY DIFFRACTION 0.257 0.230 False True IGHV5 IGKV1 Kappa None None None None None 9uzd H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap- snatching endonuclease (E668A mutant) Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 2.4 X-RAY DIFFRACTION 0.248 0.191 False True IGHV5 IGKV1 Kappa None None None None None 9uze H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap- snatching endonuclease (E682A mutant) Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 2.41 X-RAY DIFFRACTION 0.233 0.178 False True IGHV5 IGKV1 Kappa None None None None None 9uzf H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap- snatching endonuclease (D719A mutant) Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 2.47 X-RAY DIFFRACTION 0.257 0.200 False True IGHV5 IGKV1 Kappa None None None None None 9uzg H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap- snatching endonuclease in complex with 2,4-dioxo-4-phenylbutanoic acid (DPBA) Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 2.15 X-RAY DIFFRACTION 0.233 0.181 False True IGHV5 IGKV1 Kappa None None None None None 9uzh H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap- snatching endonuclease in complex with L-742,001 Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 1.95 X-RAY DIFFRACTION 0.214 0.178 False True IGHV5 IGKV1 Kappa None None None None None 9uzi H L 0 A protein NA rna-directed rna polymerase l HYDROLASE 12/31/25 Crystal structure of Kasokero virus cap- snatching endonuclease in complex with baloxavir acid (BXA) Kasokero virus; Mus musculus mus musculus mus musculus kasokero virus Deng, Z., Kuang, W., Tian, Z. 2.16 X-RAY DIFFRACTION 0.227 0.174 False True IGHV5 IGKV1 Kappa None None None None None 9v0n C B 0 A protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2042 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v0n H F 0 D protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2042 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v0n I G 0 E protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2042 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v0p H L 0 A protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2053 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9v0p D F 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2053 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9v0p E G 0 C protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2053 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9v0q A C 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2056 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v0q D H 0 F protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2056 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v0q E I 0 G protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2056 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v0s D E 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.78 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v0s F H 0 A protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.78 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v0s G I 0 C protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F in complex with antibody CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 3.78 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v2o A C 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F monomer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.27 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v2o D E 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F monomer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.27 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v2q A C 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F dimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v2q D E 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F dimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v2q F H 0 G protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F dimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v2q I J 0 G protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F dimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v2r A C 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F trimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v2r D E 0 B protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F trimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v2r F J 0 H protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F trimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v2r L N 0 H protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F trimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9v2r G K 0 I protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F trimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9v2r M O 0 I protein NA rsv pre-fusion protein VIRAL PROTEIN 12/31/25 Cryo-EM structure of RSV pre-F trimer in complex with CNR2056/CNR2047 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Zhai, H., Deng, J., Yu, W. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9yc3 A NA 0 B protein NA male gamete fusion factor hap2 PROTEIN BINDING 12/31/25 Crystal structure of malaria transmission-blocking antigen PfHAP2 domain 3 in complex with nanobody WNb 334 Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Lyons, F.M.T., Pymm, P., Dietrich, M.H., Tham, W.H. 2.8 X-RAY DIFFRACTION 0.253 0.224 False True IGHV1 NA NA None None None None None 9yka F G 0 B protein NA balf4 VIRAL PROTEIN 12/31/25 Cryo-EM structure of post-fusion EBV gB in complex with AMMO2 fab Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Chou, C.W., McCool, R.S., McLellan, J.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9yka H I 0 C protein NA balf4 VIRAL PROTEIN 12/31/25 Cryo-EM structure of post-fusion EBV gB in complex with AMMO2 fab Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Chou, C.W., McCool, R.S., McLellan, J.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9yka D E 0 A protein NA balf4 VIRAL PROTEIN 12/31/25 Cryo-EM structure of post-fusion EBV gB in complex with AMMO2 fab Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Chou, C.W., McCool, R.S., McLellan, J.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9hnr P NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein | gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 12/24/25 a5b3 GABAA Receptor in 1 a5 to 4 b3 stoichiometry in desensitized state Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens | homo sapiens Cowgill, J., Fan, C., Howard, R.J., Lindahl, E. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hnr Q NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 12/24/25 a5b3 GABAA Receptor in 1 a5 to 4 b3 stoichiometry in desensitized state Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens Cowgill, J., Fan, C., Howard, R.J., Lindahl, E. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hnr R NA 0 E protein NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 12/24/25 a5b3 GABAA Receptor in 1 a5 to 4 b3 stoichiometry in desensitized state Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens Cowgill, J., Fan, C., Howard, R.J., Lindahl, E. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hnq P NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein | gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 12/24/25 a5b3 GABAA Receptor bound to GABA and Mb25 in desensitized state in detergent micelles Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens, aequorea victoria | homo sapiens, aequorea victoria Cowgill, J., Fan, C., Howard, R.J., Lindahl, E. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hns P NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein | gamma-aminobutyric acid receptor subunit beta-3,greenfluorescent protein MEMBRANE PROTEIN 12/24/25 a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after long GABA treatment Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens, aequorea victoria | homo sapiens, aequorea victoria Cowgill, J., Fan, C., Howard, R.J., Lindahl, E. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hnt P NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3,green fluorescent protein | gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3,green fluorescent protein MEMBRANE PROTEIN 12/24/25 a5b3 GABAAR bound to Etomidate, GABA, and Mb25 in a desensitized state in saposin nanodiscs Aequorea victoria; Escherichia coli; Homo sapiens homo sapiens, aequorea victoria | homo sapiens, aequorea victoria Cowgill, J., Fan, C., Howard, R.J., Lindahl, E. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ho4 C NA 0 A protein NA frataxin mature form OXIDOREDUCTASE 12/24/25 Crystal Structure of the Human Frataxin protein in complex with a tailored Camelid Nanobody 6B1 Homo sapiens; Lama glama lama glama homo sapiens Garay-Alvarez, A., Molina, R., Hermoso, J.A. 1.76 X-RAY DIFFRACTION 0.175 0.151 False True IGHV1 NA NA None None None None None 9ho5 C NA 0 A protein NA frataxin mature form OXIDOREDUCTASE 12/24/25 Crystal Structure of the Human Frataxin protein in complex with a tailored Camelid Nanobody 4A7 Homo sapiens; Lama glama lama glama homo sapiens Garay-Alvarez, A., Molina, R., Hermoso, J.A. 1.5 X-RAY DIFFRACTION 0.210 0.187 False True IGHV1 NA NA None None None None None 9ho6 D NA 0 A protein NA frataxin mature form OXIDOREDUCTASE 12/24/25 Crystal Structure of the Human Frataxin protein in complex with a tailored Camelid Nanobody 16C10 Homo sapiens; Lama glama lama glama homo sapiens Garay-Alvarez, A., Molina, R., Hermoso, J.A. 2 X-RAY DIFFRACTION 0.227 0.180 False True IGHV1 NA NA None None None None None 9ho6 C NA 0 B protein NA frataxin mature form OXIDOREDUCTASE 12/24/25 Crystal Structure of the Human Frataxin protein in complex with a tailored Camelid Nanobody 16C10 Homo sapiens; Lama glama lama glama homo sapiens Garay-Alvarez, A., Molina, R., Hermoso, J.A. 2 X-RAY DIFFRACTION 0.227 0.180 False True IGHV1 NA NA None None None None None 9mpx H L 0 NA NA NA NA IMMUNE SYSTEM 12/24/25 Crystal structure of RM014, a macaque-derived HIV V2-apex-targeting antibody from ApexGT6 immunization Macaca macaca macaca Agrawal, S., Wilson, I.A. 1.88 X-RAY DIFFRACTION 0.242 0.191 False True IGHV1 IGKV1 Kappa None None None None None 9og1 B C 0 A protein NA a28l VIRAL PROTEIN 12/24/25 Globular domain of monkeypox virus OPG153 (A28) bound to antibody 02M12 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Rundlet, E.J., Zhou, L., McLellan, J.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9og2 B C 0 A protein NA a28l VIRAL PROTEIN 12/24/25 Globular domain of monkeypox virus OPG153 (A28) in complex with antibodies 08E11 and 12I12 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Zhou, L., Rundlet, E.J., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9og2 D E 0 A protein NA a28l VIRAL PROTEIN 12/24/25 Globular domain of monkeypox virus OPG153 (A28) in complex with antibodies 08E11 and 12I12 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Zhou, L., Rundlet, E.J., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oka NA E 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cardiac lambda-6 light chain amyloid AL-224L single protofilament Homo sapiens homo sapiens Hicks, C.W., Gursky, O., Huda, N. 2.92 ELECTRON MICROSCOPY NA NA False True NA IGLV6 Lambda None None None None None 9oka NA C 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cardiac lambda-6 light chain amyloid AL-224L single protofilament Homo sapiens homo sapiens Hicks, C.W., Gursky, O., Huda, N. 2.92 ELECTRON MICROSCOPY NA NA False True NA IGLV6 Lambda None None None None None 9oka NA D 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cardiac lambda-6 light chain amyloid AL-224L single protofilament Homo sapiens homo sapiens Hicks, C.W., Gursky, O., Huda, N. 2.92 ELECTRON MICROSCOPY NA NA False True NA IGLV6 Lambda None None None None None 9oka NA B 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cardiac lambda-6 light chain amyloid AL-224L single protofilament Homo sapiens homo sapiens Hicks, C.W., Gursky, O., Huda, N. 2.92 ELECTRON MICROSCOPY NA NA False True NA IGLV6 Lambda None None None None None 9oka NA A 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cardiac lambda-6 light chain amyloid AL-224L single protofilament Homo sapiens homo sapiens Hicks, C.W., Gursky, O., Huda, N. 2.92 ELECTRON MICROSCOPY NA NA False True NA IGLV6 Lambda None None None None None 9osx B C 0 A protein NA pfcyrpa-em IMMUNE SYSTEM 12/24/25 PfCyRPA-EM epitope mimic bound to monoclonal antibody Cy.004 Gallus gallus; synthetic construct gallus gallus gallus gallus synthetic construct Alam, N., Higgins, M.K. 2.67 X-RAY DIFFRACTION 0.292 0.254 False True unknown unknown unknown None None None None None 9p1m D C 0 A protein NA 5'-nucleotidase HYDROLASE 12/24/25 Cryo-EM structure of CD73 in complex with antibody Sym024 Homo sapiens homo sapiens homo sapiens homo sapiens Bansia, H., Armbruster, E., Des Georges, A. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9p1m F E 0 B protein NA 5'-nucleotidase HYDROLASE 12/24/25 Cryo-EM structure of CD73 in complex with antibody Sym024 Homo sapiens homo sapiens homo sapiens homo sapiens Bansia, H., Armbruster, E., Des Georges, A. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9pf9 H L 0 G protein NA bllf1 IMMUNE SYSTEM 12/24/25 X-ray crystal structure of ATX-350-2 Fab bound to Epstein-Barr virus glycoprotein 350 human gammaherpesvirus 4; Mus musculus mus musculus mus musculus human gammaherpesvirus 4 Lang, K., Kher, G., Aldridge, N.T., Pancera, M. 3.93 X-RAY DIFFRACTION 0.282 0.242 False True IGHV2 IGKV3 Kappa None None None None None 9pxb H L 0 A protein NA sterol regulatory element-binding protein cleavage-activating protein MEMBRANE PROTEIN 12/24/25 Hamster Scap/Insig-2 complex with cholesterol and bound Fab4G10 Cricetulus griseus; Mus musculus mus musculus mus musculus cricetulus griseus Williams, B.C., Kober, D.L., Bai, X., Radhakrishnan, A., Rosenbaum, D.M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV10 Kappa None None None None None 9py6 H L 0 A protein NA sterol regulatory element-binding protein cleavage-activating protein MEMBRANE PROTEIN 12/24/25 Hamster Scap/Insig-2 complex L1-L7 domain/Fab4G10 focused map Cricetulus griseus; Mus musculus mus musculus mus musculus cricetulus griseus Williams, B.C., Kober, D.L., Bai, X., Radhakrishnan, A., Rosenbaum, D.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV10 Kappa None None None None None 9py7 H L 0 A protein NA sterol regulatory element-binding protein cleavage-activating protein MEMBRANE PROTEIN 12/24/25 Hamster Scap L1-L7 domain/Fab4G10 focused map Cricetulus griseus; Mus musculus mus musculus mus musculus cricetulus griseus Williams, B.C., Kober, D.L., Bai, X., Radhakrishnan, A., Rosenbaum, D.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV10 Kappa None None None None None 9qk2 D NA 0 C | B protein | protein NA | NA complement c4-a | complement c4-a IMMUNE SYSTEM 12/24/25 Structure of the Complement classical and lectin pathway C3 convertase in complex with substrate C3 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens De la O Becerra, K.I., Brondijk, T.H.C., Gros, P. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9qpy D NA 0 C | B protein | protein NA | NA complement c4-a | complement c4-a IMMUNE SYSTEM 12/24/25 Structure of the Complement classical and lectin pathway C3 convertase Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens De la O Becerra, K.I., Brondijk, T.H.C., Gros, P. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9v6r E D 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/25 Hexameric RVFV GnGc-Fab140 complex Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Zhang, L., Meng, K., Xiang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9v6r G F 0 C protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/25 Hexameric RVFV GnGc-Fab140 complex Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Zhang, L., Meng, K., Xiang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9v6r K J 0 I protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/25 Hexameric RVFV GnGc-Fab140 complex Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Zhang, L., Meng, K., Xiang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9v6r O N 0 M protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/25 Hexameric RVFV GnGc-Fab140 complex Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Zhang, L., Meng, K., Xiang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9v6r S R 0 Q protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/25 Hexameric RVFV GnGc-Fab140 complex Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Zhang, L., Meng, K., Xiang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9v6r X W 0 V protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/25 Hexameric RVFV GnGc-Fab140 complex Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Zhang, L., Meng, K., Xiang, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9v91 NA A 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph B Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 3.0 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9v91 NA B 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph B Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 3.0 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9v91 NA C 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph B Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 3.0 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9v91 NA D 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph B Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 3.0 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9v91 NA E 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph B Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 3.0 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9v91 NA F 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph B Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 3.0 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9x45 NA A 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 2.93 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9x45 NA B 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 2.93 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9x45 NA C 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 2.93 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9x45 NA D 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 2.93 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9x45 NA E 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 2.93 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9x45 NA F 0 NA NA NA NA PROTEIN FIBRIL 12/24/25 Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A Homo sapiens homo sapiens Zhao, K., Yu, C.Y., Ma, Y.Y., Huang, H. 2.93 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9yda H h 0 A | B protein | protein NA | NA genome polyprotein,guanine nucleotide-binding protein g(s)subunit alpha isoforms xlas | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/24/25 Cryo-EM structure of active human green cone opsin in complex with chimeric G protein (miniGist) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yao, W., Fay, J.F., Farrens, D.L. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9hkq D E 0 C protein NA beta-2-microglobulin PROTEIN BINDING 12/17/25 Structure of VHH5 targeting NY-ESO-1(SLLMWITQC)/HLA-A*02:01 Homo sapiens; Mus musculus; synthetic construct; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Jie, B., Shenghai, C., Liqiang, P., Xing, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV4 Kappa None None None None None 9hkq F NA 0 B | A protein | peptide NA | NA mhc class i antigen | cancer/testis antigen 1 PROTEIN BINDING 12/17/25 Structure of VHH5 targeting NY-ESO-1(SLLMWITQC)/HLA-A*02:01 Homo sapiens; Mus musculus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Jie, B., Shenghai, C., Liqiang, P., Xing, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9l1q H L 0 E | B protein | protein NA | NA butyrophilin subfamily 3 member a2 | butyrophilin subfamily 2 member a1 IMMUNE SYSTEM 12/17/25 Cryo-EM structure of the ICT01-BTN2A1/BTN3A1/BTN3A2 complex (2 fabs) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Xin, W.Z., Huang, B.D., Zhou, Q. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV15 Kappa None None None None None 9l1q h l 0 F protein NA butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 12/17/25 Cryo-EM structure of the ICT01-BTN2A1/BTN3A1/BTN3A2 complex (2 fabs) Homo sapiens homo sapiens homo sapiens homo sapiens Xin, W.Z., Huang, B.D., Zhou, Q. 4.0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV15 Kappa None None None None None 9pni H L 0 A | C protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM structure of J601-1B2 Fab in complex with HIV-1 BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Zhou, T., Kwong, P.D. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pni J K 0 B | G protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM structure of J601-1B2 Fab in complex with HIV-1 BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Zhou, T., Kwong, P.D. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pni D E 0 F | I protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM structure of J601-1B2 Fab in complex with HIV-1 BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Zhou, T., Kwong, P.D. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pnn H L 0 B | G protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM structure of J601-A6 Fab in complex with HIV-1 BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Zhou, T., Kwong, P.D., Morano, N.C., Shapiro, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pnn D E 0 A | C protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM structure of J601-A6 Fab in complex with HIV-1 BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Zhou, T., Kwong, P.D., Morano, N.C., Shapiro, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pnn J K 0 F | I protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM structure of J601-A6 Fab in complex with HIV-1 BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Zhou, T., Kwong, P.D., Morano, N.C., Shapiro, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9ytd H L 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a alpha chain | prostatic acid phosphatase-derived peptide DE NOVO PROTEIN/IMMUNE SYSTEM 12/17/25 Designed antibody vAB66 targeting PAP-HLA A*02:01 Homo sapiens; Lama glama; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens | homo sapiens Jude, K.M., Garcia, K.C. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9ytd D NA 0 B protein NA beta-2-microglobulin DE NOVO PROTEIN/IMMUNE SYSTEM 12/17/25 Designed antibody vAB66 targeting PAP-HLA A*02:01 Homo sapiens; Lama glama; synthetic construct; SYNTHETIC CONSTRUCT lama glama homo sapiens Jude, K.M., Garcia, K.C. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ytf F G 0 A | C protein | peptide NA | NA mhc class i antigen | melanoma-associated antigen 3 IMMUNE SYSTEM 12/17/25 TCR mimic antibody vAB-30 in complex with MAGE-A3 in HLA-A1 Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens | homo sapiens Wang, N., Jude, K.M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ytf D NA 0 B protein NA beta-2-microglobulin IMMUNE SYSTEM 12/17/25 TCR mimic antibody vAB-30 in complex with MAGE-A3 in HLA-A1 Homo sapiens; synthetic construct homo sapiens homo sapiens Wang, N., Jude, K.M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hll B NA 0 A protein NA integrin alpha-m IMMUNE SYSTEM 12/17/25 murine aM I-domain in complex with nanobody aCR3 Lama glama; Mus musculus lama glama mus musculus Fruergaard, M.U., Andersen, G.R. 2.17 X-RAY DIFFRACTION 0.259 0.202 False True IGHV1 NA NA None None None None None 9hll C NA 0 A protein NA integrin alpha-m IMMUNE SYSTEM 12/17/25 murine aM I-domain in complex with nanobody aCR3 Lama glama; Mus musculus lama glama mus musculus Fruergaard, M.U., Andersen, G.R. 2.17 X-RAY DIFFRACTION 0.259 0.202 False True IGHV1 NA NA None None None None None 9hll D NA 0 NA NA NA NA IMMUNE SYSTEM 12/17/25 murine aM I-domain in complex with nanobody aCR3 Lama glama; Mus musculus lama glama Fruergaard, M.U., Andersen, G.R. 2.17 X-RAY DIFFRACTION 0.259 0.202 False True IGHV1 NA NA None None None None None 9jic S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM Structure of the apo HCAR3-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Fang, Y., Fang, Y. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jid S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 12/17/25 Cryo-EM Structure of the niacin-HCAR3-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Fang, Y., Fang, Y. 2.78 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kwz H L 0 E | B protein | protein NA | NA butyrophilin subfamily 3 member a2 | butyrophilin subfamily 2 member a1 IMMUNE SYSTEM 12/17/25 Cryo-EM structure of the ICT01-BTN2A1/BTN3A1/BTN3A2 complex Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Xin, W.Z., Huang, B.D., Zhou, Q. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV15 Kappa None None None None None 9l1o H L 0 E protein NA butyrophilin subfamily 3 member a2 IMMUNE SYSTEM 12/17/25 Cryo-EM structure of the ICT01-BTN3A1/BTN3A2 complex, local refinement Homo sapiens homo sapiens homo sapiens homo sapiens Xin, W.Z., Huang, B.D., Zhou, Q. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV15 Kappa None None None None None 9l1p H L 0 E | B protein | protein NA | NA butyrophilin subfamily 3 member a2 | butyrophilin subfamily 2 member a1 IMMUNE SYSTEM 12/17/25 Cryo-EM structure of the ICT01-BTN2A1/BTN3A1/BTN3A2 complex, local refinement Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Xin, W.Z., Huang, B.D., Zhou, Q. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV15 Kappa None None None None None 9m57 S s 0 A | B | G protein | protein | peptide NA | NA | NA g-protein alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | g-protein gamma subunit SIGNALING PROTEIN 12/17/25 Structural insight into determinants of endogenous agonist selectivity of aminergic receptors from octopamine b2 receptor structure Homo sapiens; Ixodes scapularis; Mus musculus mus musculus ixodes scapularis | homo sapiens | homo sapiens Hori, T., Katsura, K., Shirouzu, M. 3.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9m5b A B 0 C protein NA low affinity immunoglobulin gamma fc region receptor ii-b IMMUNE SYSTEM 12/17/25 A Human Fc Receptor Ectodomain in Complex With a Fab Homo sapiens homo sapiens homo sapiens homo sapiens Zhao, Z., Wang, H., Duan, Y., Zhang, H., Yang, H. 1.66 X-RAY DIFFRACTION 0.218 0.189 False True IGHV3 IGKV1 Kappa None None None None None 9nww D C 0 B protein NA probable phosphatidylethanolamine transferase mcr-1 TRANSFERASE 12/17/25 Single-particle cryo-EM structure of the first variant of mobilized colistin resistance (MCR-1) in its ligand-bound state Escherichia coli; Homo sapiens homo sapiens homo sapiens escherichia coli Zinkle, A.P., Bunuro-Batista, M., Herrera, C.M., Erramilli, S.K., Kloss, B., Ashraf, K.U., Nosol, K., Zhang, G., Cater, R.J., Marty, M.T., Kossiakoff, A.A., Trent, M.S., Nygaard, R., Stansfeld, P.J., Mancia, F. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ocl H L 0 1 | 2 protein | protein NA | NA capsid protein vp1 | capsid protein vp2 VIRUS 12/17/25 PV2-10D2 Complex Homo sapiens; Poliovirus 2 homo sapiens homo sapiens poliovirus 2 | poliovirus 2 Waddey, B.T., Hafenstein, S.L. 3.65 ELECTRON MICROSCOPY NA NA False False IGHV6 IGLV2 Lambda None None None None None 9oco H L 0 1 | 2 protein | protein NA | NA vp1 | vp2 VIRUS 12/17/25 SIPV3-2E1 Complex Homo sapiens; Poliovirus 3 homo sapiens homo sapiens poliovirus 3 | poliovirus 3 Waddey, B.T., Hafenstein, S.L. 2.95 ELECTRON MICROSCOPY NA NA False False IGHV5 IGLV6 Lambda None None None None None 9od3 H L 0 1 | 2 protein | protein NA | NA vp1 | vp2 VIRUS 12/17/25 SIPV3-6B5 Complex Homo sapiens; Poliovirus 3 homo sapiens homo sapiens poliovirus 3 | poliovirus 3 Waddey, B.T., Hafenstein, S.L. 2.94 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 9oea H L 0 1 | 2 protein | protein NA | NA capsid protein vp1 | capsid protein vp2 VIRUS 12/17/25 SIPV1-5E12 Complex Homo sapiens; Human poliovirus 1 strain Sabin homo sapiens homo sapiens human poliovirus 1 strain sabin | human poliovirus 1 strain sabin Waddey, B.T., Hafenstein, S.L. 2.84 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 9pd2 H L 0 A protein NA paired immunoglobulin-like type 2 receptor alpha SIGNALING PROTEIN 12/17/25 Crystal structure of PILRA in complex with Fab portion of antagonist antibody Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E. 2.579 X-RAY DIFFRACTION 0.277 0.226 False True IGHV1 IGKV1 Kappa None None None None None 9pzs F G 0 A protein NA glutamate receptor ionotropic, nmda 1 TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A/GluN2B in complex with 5F11 and 3D2 Fabs (class 1), glycine and glutamate bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9pzs J K 0 B protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A/GluN2B in complex with 5F11 and 3D2 Fabs (class 1), glycine and glutamate bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9pzs H I 0 C protein NA glutamate receptor ionotropic, nmda 1 TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A/GluN2B in complex with 5F11 and 3D2 Fabs (class 1), glycine and glutamate bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9pzt L M 0 D protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs (class 3), glycine and glutamate-bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 6.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9pzt H I 0 C protein NA glutamate receptor ionotropic, nmda 1 TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs (class 3), glycine and glutamate-bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 6.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9pzt J K 0 B protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs (class 3), glycine and glutamate-bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 6.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9pzt F G 0 A protein NA glutamate receptor ionotropic, nmda 1 TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs (class 3), glycine and glutamate-bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 6.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9pzu F G 0 A protein NA glutamate receptor ionotropic, nmda 1 TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2B in complex with 5F11 Fab (class 4), glycine and glutamate-bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 5.36 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9pzu H I 0 C protein NA glutamate receptor ionotropic, nmda 1 TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2B in complex with 5F11 Fab (class 4), glycine and glutamate-bound state Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 5.36 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9pzv H I 0 A protein NA glutamate receptor ionotropic, nmda 1 TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs, local ATD dimer Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 3.92 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9pzv J K 0 B protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 12/17/25 Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs, local ATD dimer Mus musculus mus musculus mus musculus mus musculus Kim, J., Gouaux, E. 3.92 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9pzw J K 0 B protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 12/17/25 GluN1/GluN2A in complex with 3D2 Fab, glycine and glutamate-bound state Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Kim, J., Gouaux, E. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9pzw L M 0 D protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 12/17/25 GluN1/GluN2A in complex with 3D2 Fab, glycine and glutamate-bound state Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Kim, J., Gouaux, E. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9pzx J K 0 B protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 12/17/25 GluN1/GluN2A in complex with 3D2 Fab, local ATD dimer Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Kim, J., Gouaux, E. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9vx2 A B 0 NA NA NA NA IMMUNE SYSTEM 12/17/25 Crystal structure of the apo form of HisMab-1 Fab Mus musculus mus musculus mus musculus Hoshi, S., Arimori, T., Harada-Hikita, A. 2.39 X-RAY DIFFRACTION 0.288 0.232 False True IGHV1 IGKV8 Kappa None None None None None 9vx2 C D 0 NA NA NA NA IMMUNE SYSTEM 12/17/25 Crystal structure of the apo form of HisMab-1 Fab Mus musculus mus musculus mus musculus Hoshi, S., Arimori, T., Harada-Hikita, A. 2.39 X-RAY DIFFRACTION 0.288 0.232 False True IGHV1 IGKV8 Kappa None None None None None 9vx3 A B 0 C peptide NA polyhistidine peptide IMMUNE SYSTEM 12/17/25 Crystal structure of the peptide-bound form of HisMab-1 Fv-clasp Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens synthetic construct Hitomi, N., Harada-Hikita, A., Arimori, T. 2.39 X-RAY DIFFRACTION 0.237 0.196 False True IGHV1 IGKV8 Kappa None None None None None 9vx3 D E 0 F peptide NA polyhistidine peptide IMMUNE SYSTEM 12/17/25 Crystal structure of the peptide-bound form of HisMab-1 Fv-clasp Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens synthetic construct Hitomi, N., Harada-Hikita, A., Arimori, T. 2.39 X-RAY DIFFRACTION 0.237 0.196 False True IGHV1 IGKV8 Kappa None None None None None 9z5q A NA 0 B protein NA e3 ubiquitin-protein ligase nedd4-like LIGASE 12/17/25 HECT domain of NEDD4-2 complex with a targeted nanobody, nb.C11 Homo sapiens; Lama glama lama glama homo sapiens Afriyie, E., Clarke, O.B. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9glz C NA 0 A protein NA gtpase kras HYDROLASE 12/10/25 KRas-G12D-GMPPnP in complex with the nanobody KM12-AM Homo sapiens homo sapiens homo sapiens Ostermann, N., Zink, F. 2.1 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 NA NA None None None None None 9glz D NA 0 B protein NA gtpase kras HYDROLASE 12/10/25 KRas-G12D-GMPPnP in complex with the nanobody KM12-AM Homo sapiens homo sapiens homo sapiens Ostermann, N., Zink, F. 2.1 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 NA NA None None None None None 9hih H L 0 NA NA NA NA CYTOKINE/IMMUNE SYSTEM 12/10/25 Mouse IL-2 fused to S4B6 Fab fragment Mus musculus; Rattus norvegicus rattus norvegicus mus musculus Blaha, J., Skorepa, O., Vanek, O. 2.7 X-RAY DIFFRACTION 0.276 0.235 False True IGHV1 IGKV12 Kappa None None None None None 9hj9 C D 0 B protein NA hemagglutinin VIRAL PROTEIN 12/10/25 H1-H3 chimeric hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seraj, N., Harshbarger, W., Mallett, C.P., Vassilev, V. 2.06 X-RAY DIFFRACTION 0.210 0.168 False True IGHV4 IGKV1 Kappa None None None None None 9hjk B NA 0 A protein NA cationic amino acid transporter 4, vacuolar MEMBRANE PROTEIN 12/10/25 Cryo-EM structure of the Arabidopsis thaliana CAT4 transporter in the outward-open apo state Arabidopsis thaliana; synthetic construct synthetic construct arabidopsis thaliana Kolokouris, D., Kato, T., Newstead, S. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kt7 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of HCA2-Gi complex with MK6892 Homo sapiens homo sapiens homo sapiens | homo sapiens Wu, S., Wu, S. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kt8 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of HCA2-Gi complex with acifran Homo sapiens homo sapiens homo sapiens | homo sapiens Wu, S. 2.73 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kt9 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of HCA1-Gi complex with 3,5-DHBA Homo sapiens homo sapiens homo sapiens | homo sapiens Wu, S. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kvj C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 BA.5 spike protein in complex with nAb 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.82 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 9kvk H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 spike protein in complex with three-nAb 8H12, 3E2 and 1C4 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.44 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 9kvk A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 spike protein in complex with three-nAb 8H12, 3E2 and 1C4 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.44 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 9kvk C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 spike protein in complex with three-nAb 8H12, 3E2 and 1C4 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.44 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 9kvq H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 BA.1 spike protein in complex with three-nAb 8H12, 3E2 and 1C4 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.95 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 9kvq A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 BA.1 spike protein in complex with three-nAb 8H12, 3E2 and 1C4 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.95 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 9kvq C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 BA.1 spike protein in complex with three-nAb 8H12, 3E2 and 1C4 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.95 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 9kvt H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 BA.2 spike protein in complex with triple-nAb 8H12, 3E2 and 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 9kvt A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 BA.2 spike protein in complex with triple-nAb 8H12, 3E2 and 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 9kvt C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Cryo-EM structure of SARS-CoV-2 BA.2 spike protein in complex with triple-nAb 8H12, 3E2 and 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Li, S., Zheng, Q. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 9kwe H L 0 E protein NA butyrophilin subfamily 3 member a2 IMMUNE SYSTEM 12/10/25 Cryo-EM structure of the ICT01-BTN3A1/BTN3A2 complex Homo sapiens homo sapiens homo sapiens homo sapiens Xin, W.Z., Huang, B.D., Zhou, Q. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV15 Kappa None None None None None 9kzd H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 The local refined map of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-171 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kze H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 The local refined map of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-183 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9kzz H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-171 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kzz I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-171 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kzz J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-171 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9l05 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 The local refined map of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-198 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l07 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 The local refined map of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-203 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 3.28 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l15 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-203 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l15 I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-203 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l15 J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-203 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l2l G P 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-198 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l2l K Q 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-198 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l2l O R 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-198 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l2l J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-198 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l2l H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-198 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9l2l I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 Structure of SARS-CoV-2 EG.5.1 Variant Spike protein complexed with antibody XGi-198 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qiu, Y.N., Sun, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 9lad B NA 0 C protein NA neuronal pentraxin-2 PROTEIN BINDING 12/10/25 Crystal structure of the complex between Neuronal Pentraxin 2 (NP2 PTX) and antibody fragment VHH N1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Caaveiro, J.M.M., Yokoo, T., Tsumoto, K. 2.02 X-RAY DIFFRACTION 0.220 0.182 False True IGHV1 NA NA None None None None None 9n6e A B 0 I protein NA l9-targeting immunogen IMMUNE SYSTEM/DE NOVO PROTEIN 12/10/25 L9-targeting immunogen bound to three copies of L9 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Garfinkle, S.E., Lin, Z.J., Pallesen, J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9n6e C D 0 I protein NA l9-targeting immunogen IMMUNE SYSTEM/DE NOVO PROTEIN 12/10/25 L9-targeting immunogen bound to three copies of L9 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Garfinkle, S.E., Lin, Z.J., Pallesen, J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9n6e H L 0 I protein NA l9-targeting immunogen IMMUNE SYSTEM/DE NOVO PROTEIN 12/10/25 L9-targeting immunogen bound to three copies of L9 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Garfinkle, S.E., Lin, Z.J., Pallesen, J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ojv C D 0 F nucleic-acid NA rna strand2 RNA BINDING PROTEIN/RNA 12/10/25 Crystal structure of monoclonal J2 antibody bound to dsRNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Bou-Nader, C., Zhang, J. 2.85 X-RAY DIFFRACTION 0.262 0.212 False True IGHV1 IGKV8 Kappa None None None None None 9ojv A B 0 E nucleic-acid NA rna strand1 RNA BINDING PROTEIN/RNA 12/10/25 Crystal structure of monoclonal J2 antibody bound to dsRNA Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Bou-Nader, C., Zhang, J. 2.85 X-RAY DIFFRACTION 0.262 0.212 False True IGHV1 IGKV8 Kappa None None None None None 9pi9 A B 0 E protein NA tumor-associated calcium signal transducer 2 SIGNALING PROTEIN 12/10/25 Sacituzumab Fab bound to Trop2 Dimer Homo sapiens homo sapiens homo sapiens homo sapiens Ferrao, R.F., Lansdon, E.B. 1.56 X-RAY DIFFRACTION 0.211 0.181 False True IGHV7 IGKV6 Kappa None None None None None 9pi9 C D 0 F protein NA tumor-associated calcium signal transducer 2 SIGNALING PROTEIN 12/10/25 Sacituzumab Fab bound to Trop2 Dimer Homo sapiens homo sapiens homo sapiens homo sapiens Ferrao, R.F., Lansdon, E.B. 1.56 X-RAY DIFFRACTION 0.211 0.181 False True IGHV7 IGKV6 Kappa None None None None None 9pv3 B C 0 D protein NA 10e8-gt12 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 10E8-GT12 immunogen in complex with mouse Fabs SA2911 and W6-10 Mus musculus; synthetic construct mus musculus mus musculus synthetic construct Huang, J., Ward, A.B. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV12 Kappa None None None None None 9pv3 H L 0 D protein NA 10e8-gt12 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 10E8-GT12 immunogen in complex with mouse Fabs SA2911 and W6-10 Mus musculus; synthetic construct mus musculus mus musculus synthetic construct Huang, J., Ward, A.B. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV8 Kappa None None None None None 9pv4 A B 0 C protein NA 10e8-gt12 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 MPER-GT12 immunogen in complex with human Fab 10E8 and mouse Fab W6-10 Homo sapiens; Mus musculus; synthetic construct mus musculus mus musculus synthetic construct Huang, J., Ward, A.B. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV12 Kappa None None None None None 9pv4 H L 0 C protein NA 10e8-gt12 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 MPER-GT12 immunogen in complex with human Fab 10E8 and mouse Fab W6-10 Homo sapiens; Mus musculus; synthetic construct homo sapiens homo sapiens synthetic construct Huang, J., Ward, A.B. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9pv5 H L 0 C protein NA 10e8-gt10.2 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 10E8-GT10.2 immunogen in complex with Rhesus macaque Fab W3-05 and mouse Fab W6-03 Macaca mulatta; Mus musculus; synthetic construct mus musculus mus musculus synthetic construct Huang, J., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV8 Kappa None None None None None 9pv5 A B 0 C protein NA 10e8-gt10.2 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 12/10/25 10E8-GT10.2 immunogen in complex with Rhesus macaque Fab W3-05 and mouse Fab W6-03 Macaca mulatta; Mus musculus; synthetic construct macaca mulatta macaca mulatta synthetic construct Huang, J., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9ydp N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms xlas | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/10/25 Human delta opioid receptor complex with mini-Gi and agonist DADLE Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Mobbs, J.I., Venugopal, H., Thal, D.M. 1.95 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9yq2 B NA 0 A protein NA hyaluronan synthase TRANSFERASE/IMMUNE SYSTEM 12/10/25 Chlorella virus hyaluronan synthase bound to DDM Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9yq2 C NA 0 A protein NA hyaluronan synthase TRANSFERASE/IMMUNE SYSTEM 12/10/25 Chlorella virus hyaluronan synthase bound to DDM Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9yq4 B NA 0 A protein NA hyaluronan synthase TRANSFERASE/IMMUNE SYSTEM 12/10/25 Chlorella virus hyaluronan synthase bound to a proofreading UDP-GlcA Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9yq4 C NA 0 A protein NA hyaluronan synthase TRANSFERASE/IMMUNE SYSTEM 12/10/25 Chlorella virus hyaluronan synthase bound to a proofreading UDP-GlcA Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9yq5 B NA 0 A protein NA hyaluronan synthase TRANSFERASE/IMMUNE SYSTEM 12/10/25 Chlorella virus hyaluronan synthase bound to an inserted UDP-GlcA Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9yq5 C NA 0 A protein NA hyaluronan synthase TRANSFERASE/IMMUNE SYSTEM 12/10/25 Chlorella virus hyaluronan synthase bound to an inserted UDP-GlcA Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9z3q B A 0 E protein NA envelope glycoprotein h IMMUNE SYSTEM 12/10/25 Cryo-EM structure of KSHV glycoprotein gHgL in complex with MLKH3 and MLKH10 FABs Human gammaherpesvirus 8; Mus musculus mus musculus mus musculus human gammaherpesvirus 8 Lang, K., Aldridge, N., Pancera, M. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9z3q D C 0 E protein NA envelope glycoprotein h IMMUNE SYSTEM 12/10/25 Cryo-EM structure of KSHV glycoprotein gHgL in complex with MLKH3 and MLKH10 FABs Human gammaherpesvirus 8; Mus musculus mus musculus mus musculus human gammaherpesvirus 8 Lang, K., Aldridge, N., Pancera, M. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9nry X NA 0 B | Q protein | protein NA | NA e1 envelope glycoprotein | e2 envelope glycoprotein Viral protein/Immune System 12/03/25 Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V2C3 Lama glama; Venezuelan equine encephalitis virus lama glama venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Pletnev, S., Kwong, P.D., Zhou, T. 6.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9nry Y NA 0 O | N protein | protein NA | NA e1 envelope glycoprotein | e2 envelope glycoprotein Viral protein/Immune System 12/03/25 Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V2C3 Lama glama; Venezuelan equine encephalitis virus lama glama venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Pletnev, S., Kwong, P.D., Zhou, T. 6.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9nry Z NA 0 G | J protein | protein NA | NA e1 envelope glycoprotein | e2 envelope glycoprotein Viral protein/Immune System 12/03/25 Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V2C3 Lama glama; Venezuelan equine encephalitis virus lama glama venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Pletnev, S., Kwong, P.D., Zhou, T. 6.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9nrz X NA 0 Q | B protein | protein NA | NA e2 envelope glycoprotein | e1 envelope glycoprotein Viral protein/Immune System 12/03/25 Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V3A8f Lama glama; Venezuelan equine encephalitis virus lama glama venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Pletnev, S., Kwong, P.D., Zhou, T. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9nrz Y NA 0 J | G protein | protein NA | NA e2 envelope glycoprotein | e1 envelope glycoprotein Viral protein/Immune System 12/03/25 Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V3A8f Lama glama; Venezuelan equine encephalitis virus lama glama venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Pletnev, S., Kwong, P.D., Zhou, T. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9nrz Z NA 0 N | O protein | protein NA | NA e2 envelope glycoprotein | e1 envelope glycoprotein Viral protein/Immune System 12/03/25 Venezuelan Equine Encephalitis Virus in complex with the single domain antibody V3A8f Lama glama; Venezuelan equine encephalitis virus lama glama venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Pletnev, S., Kwong, P.D., Zhou, T. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9ot6 C NA 0 F | E protein | protein NA | NA tetratricopeptide repeat protein 7b | hyccin SIGNALING PROTEIN 12/03/25 Cryo-EM structure of the PI4KA complex bound to an EFR3 interfering nanobody (F3IN) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Shaw, A.L., Suresh, S., Yip, C.K., Burke, J.E. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ot6 H NA 0 D | G protein | protein NA | NA tetratricopeptide repeat protein 7b | hyccin SIGNALING PROTEIN 12/03/25 Cryo-EM structure of the PI4KA complex bound to an EFR3 interfering nanobody (F3IN) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Shaw, A.L., Suresh, S., Yip, C.K., Burke, J.E. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eht B A 0 J protein NA programmed cell death protein 1 IMMUNE SYSTEM 12/03/25 Crystal Structure of PD-1/retifanlimab complex Homo sapiens homo sapiens homo sapiens homo sapiens Heo, Y.-S. 1.544 X-RAY DIFFRACTION 0.208 0.181 False True IGHV1 IGKV3 Kappa None None None None None 9eht E D 0 F protein NA programmed cell death protein 1 IMMUNE SYSTEM 12/03/25 Crystal Structure of PD-1/retifanlimab complex Homo sapiens homo sapiens homo sapiens homo sapiens Heo, Y.-S. 1.544 X-RAY DIFFRACTION 0.208 0.181 False True IGHV1 IGKV3 Kappa None None None None None 9ei0 E NA 0 B protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein IMMUNE SYSTEM 12/03/25 Human Kv1.3 mutant - G427H with A0194009G09 nanobodies Homo sapiens; Lama glama lama glama homo sapiens Selvakumar, P., Swartz, K.J. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ei0 F NA 0 C protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein IMMUNE SYSTEM 12/03/25 Human Kv1.3 mutant - G427H with A0194009G09 nanobodies Homo sapiens; Lama glama lama glama homo sapiens Selvakumar, P., Swartz, K.J. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ei0 G NA 0 D protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein IMMUNE SYSTEM 12/03/25 Human Kv1.3 mutant - G427H with A0194009G09 nanobodies Homo sapiens; Lama glama lama glama homo sapiens Selvakumar, P., Swartz, K.J. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ei0 H NA 0 A protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein IMMUNE SYSTEM 12/03/25 Human Kv1.3 mutant - G427H with A0194009G09 nanobodies Homo sapiens; Lama glama lama glama homo sapiens Selvakumar, P., Swartz, K.J. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hi4 A B 0 D protein NA fi6-focused design_03 BIOSYNTHETIC PROTEIN 12/03/25 Structure of FI6-focused design_03 scaffold in complex with FI6-Fab Bacteroides uniformis ATCC 8492; Homo sapiens homo sapiens homo sapiens bacteroides uniformis atcc 8492 Cramer, J.T., Krey, T. 2 X-RAY DIFFRACTION 0.196 0.170 False True IGHV3 IGKV4 Kappa None None None None None 9hi4 K L 0 C protein NA fi6-focused design_03 BIOSYNTHETIC PROTEIN 12/03/25 Structure of FI6-focused design_03 scaffold in complex with FI6-Fab Bacteroides uniformis ATCC 8492; Homo sapiens homo sapiens homo sapiens bacteroides uniformis atcc 8492 Cramer, J.T., Krey, T. 2 X-RAY DIFFRACTION 0.196 0.170 False True IGHV3 IGKV4 Kappa None None None None None 9hi6 H L 0 A protein NA fi6-focused design_04 BIOSYNTHETIC PROTEIN 12/03/25 Structure of scaffold FI6-focused design_04 in complex with FI6-Fab Bacteroides uniformis ATCC 8492; Homo sapiens homo sapiens homo sapiens bacteroides uniformis atcc 8492 Cramer, J.T., Krey, T. 1.5 X-RAY DIFFRACTION 0.204 0.178 False True IGHV3 IGKV4 Kappa None None None None None 9jfk N NA 0 B | A protein | protein NA | NA g subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/03/25 Cryo-EM structure of [Pen5]-urotensin (4-11)-bounded human Urotensin receptor (UTS2R)-Gq complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Xu, H.E., You, C., Gao, T., Duan, J. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9kvg E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/03/25 A Cryo_EM structure of 5_HT1A complex with 5-Meo-DMT Homo sapiens homo sapiens homo sapiens | homo sapiens Yuan, Q., Li, S. 2.63 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ofo H L 0 A protein NA surface glycoprotein VIRAL PROTEIN 12/03/25 HCoV-229E S2P bound by three DH1533 Fabs Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Wrapp, D. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ofo M N 0 B protein NA surface glycoprotein VIRAL PROTEIN 12/03/25 HCoV-229E S2P bound by three DH1533 Fabs Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Wrapp, D. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ofo O P 0 C protein NA surface glycoprotein VIRAL PROTEIN 12/03/25 HCoV-229E S2P bound by three DH1533 Fabs Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Wrapp, D. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ofp H L 0 A protein NA surface glycoprotein VIRAL PROTEIN 12/03/25 HCoV-229E S2P bound by two DH1533 Fabs Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Wrapp, D. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ofp M N 0 B protein NA surface glycoprotein VIRAL PROTEIN 12/03/25 HCoV-229E S2P bound by two DH1533 Fabs Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Wrapp, D. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ofq H L 0 A protein NA surface glycoprotein VIRAL PROTEIN 12/03/25 HCoV-229E S2P bound by one DH1533 Fab Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Wrapp, D. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9op1 A B 0 C protein NA transmembrane protein gp41,fluoride export protein 1 MEMBRANE PROTEIN 12/03/25 Cryo-EM structure of Candida albicans fluoride channel FEX in complex with Fab fragment Candida albicans SC5314; HIV-1 M:B_MN; Homo sapiens homo sapiens homo sapiens hiv-1 m Kang, C.-Y., An, M.J., Ohi, M.D., Stockbridge, R.B. 4.05 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9pz5 H L 0 NA NA NA NA IMMUNE SYSTEM 12/03/25 Native anti-NANP Fab Homo sapiens homo sapiens homo sapiens Young, T. 2.39 X-RAY DIFFRACTION 0.256 0.194 False True IGHV3 IGLV1 Lambda None None None None None 9pz6 H L 0 NA NA NA NA IMMUNE SYSTEM 12/03/25 Anti-NANP Fab with G112T light chain mutation Homo sapiens homo sapiens homo sapiens Young, T. 1.7 X-RAY DIFFRACTION 0.231 0.197 False True IGHV3 IGLV1 Lambda None None None None None 9q0p A B 0 NA NA NA NA IMMUNE SYSTEM 12/03/25 Human anti-EBV gH/gL Fab (AMMO1) with G111T light chain mutation Homo sapiens homo sapiens homo sapiens Young, T. 2.08 X-RAY DIFFRACTION 0.243 0.189 False True IGHV1 IGLV3 Lambda None None None None None 9vi9 S s 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/03/25 Cryo-EM Structure of NPFFR1 in complex with peptide RFRP-3 Homo sapiens homo sapiens homo sapiens | homo sapiens Na, M., Xu, F. 3.02 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9vif S s 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/03/25 Cryo-EM Structure of NPFFR1 in complex with peptide NPFF Homo sapiens homo sapiens homo sapiens | homo sapiens Na, M., Xu, F. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9xgo H L 0 N protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/03/25 Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z.Q., Niu, X. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9jy2 B A 0 e protein NA unknown IMMUNE SYSTEM 11/26/25 Fab-CD3-delta epsilon-TCR complex Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9ky2 B C 0 F | U protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN 11/26/25 Structure of beta-arrestin2 in complex with mouse C5aR1pp Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | mus musculus Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ky2 D E 0 A | V protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN 11/26/25 Structure of beta-arrestin2 in complex with mouse C5aR1pp Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | mus musculus Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kyu I M 0 A | U protein | peptide NA | NA beta-arrestin-1 | c5ar1 phosphopeptide SIGNALING PROTEIN 11/26/25 Structure of beta-arrestin1 in complex with mouse C5aR1pp Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | mus musculus Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kyu R Q 0 D | X protein | peptide NA | NA beta-arrestin-1 | c5ar1 phosphopeptide SIGNALING PROTEIN 11/26/25 Structure of beta-arrestin1 in complex with mouse C5aR1pp Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | mus musculus Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9njl H L 0 B | A protein | protein NA | NA envelope glycoprotein gp2 | envelope glycoprotein gp1 VIRAL PROTEIN 11/26/25 MARV GP in complex with MARV16 Fab Mus musculus; Orthomarburgvirus marburgense mus musculus mus musculus orthomarburgvirus marburgense | orthomarburgvirus marburgense Addetia, A., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9njl I N 0 D | C protein | protein NA | NA envelope glycoprotein gp2 | envelope glycoprotein gp1 VIRAL PROTEIN 11/26/25 MARV GP in complex with MARV16 Fab Mus musculus; Orthomarburgvirus marburgense mus musculus mus musculus orthomarburgvirus marburgense | orthomarburgvirus marburgense Addetia, A., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9njl J P 0 F | E protein | protein NA | NA envelope glycoprotein gp2 | envelope glycoprotein gp1 VIRAL PROTEIN 11/26/25 MARV GP in complex with MARV16 Fab Mus musculus; Orthomarburgvirus marburgense mus musculus mus musculus orthomarburgvirus marburgense | orthomarburgvirus marburgense Addetia, A., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9wp9 C c 0 A protein NA engineered g-alpha-q MEMBRANE PROTEIN 11/26/25 Cryo-EM structure of the d18:1 S1P-bound S1PR3 and Gq complex Homo sapiens homo sapiens homo sapiens Im, D., Asada, H., Iwata, S., Yamauchi, M., Hagiwara, M. 3.25 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9wp9 N NA 0 A | B protein | protein NA | NA engineered g-alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/26/25 Cryo-EM structure of the d18:1 S1P-bound S1PR3 and Gq complex Homo sapiens homo sapiens homo sapiens | homo sapiens Im, D., Asada, H., Iwata, S., Yamauchi, M., Hagiwara, M. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9i59 H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN 11/26/25 RVFV GnH complexed with RVFV-379 Fab Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Paesen, G.C., Bowden, T.A. 2.09 X-RAY DIFFRACTION 0.251 0.212 False True IGHV4 IGKV1 Kappa None None None None None 9i59 X Y 0 B protein NA envelopment polyprotein VIRAL PROTEIN 11/26/25 RVFV GnH complexed with RVFV-379 Fab Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Paesen, G.C., Bowden, T.A. 2.09 X-RAY DIFFRACTION 0.251 0.212 False True IGHV4 IGKV1 Kappa None None None None None 9ia3 B A 0 E peptide NA large s protein IMMUNE SYSTEM 11/26/25 Bc8.108 Fab bound to preS2 peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis b virus Mechaly, A.E., Haouz, A., Beretta, M., Caillet-Saguy, C., Mouquet, H. 1.11 X-RAY DIFFRACTION 0.187 0.173 False True IGHV1 IGKV3 Kappa None None None None None 9ia4 B A 0 NA NA NA NA IMMUNE SYSTEM 11/26/25 Bc8.108 Fab Homo sapiens homo sapiens homo sapiens Mechaly, A.E., Haouz, A., Beretta, M., Caillet-Saguy, C., Mouquet, H. 2.36 X-RAY DIFFRACTION 0.280 0.218 False True IGHV1 IGKV3 Kappa None None None None None 9iat B A 0 NA NA NA NA IMMUNE SYSTEM 11/26/25 Bc8.121 Fab Homo sapiens homo sapiens homo sapiens Mechaly, A.E., Haouz, A., Beretta, M., Caillet-Saguy, C., Mouquet, H. 1.54 X-RAY DIFFRACTION 0.232 0.199 False True IGHV3 IGLV1 Lambda None None None None None 9ko4 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/26/25 A Cryo_EM structure of CCR7 complex with CCL21 Homo sapiens homo sapiens homo sapiens | homo sapiens Yuan, Q., Duan, J., Cao, Y. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kug H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of EP67 bound to human C5aR1 in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Ganguly, M., Yadav, M.K., Mishra, S., Dalal, A., Shukla, A.K. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kv6 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of mouse TLQP21 bound to mouse C3aR in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 2.88 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kv8 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of human TLQP21 bound to mouse C3aR in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.17 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kwg H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of mouse C5a bound mouse C5aR1 in complex with Go Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, M.K., Yadav, R., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kwx H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of mouse C5a-desArg bound mouse C5aR1 in complex with Go Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, M.K., Yadav, R., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.13 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kx6 H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of human C5a-desArg bound mouse C5aR1 in complex with Go Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, M.K., Yadav, R., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.11 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kxs H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of EP67 bound mouse C5aR1 in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.31 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kz2 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of EP67 bound human C3aR in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.43 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kz8 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of EP67 bound mouse C3aR in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kzk H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of mouse C3a bound mouse C3aR in complex with Go Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.54 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lu3 H L 0 A protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/26/25 LN1F9 Fab bound to Nipah Virus attachment (G) glycoprotein head domain Henipavirus nipahense; Mus musculus mus musculus mus musculus henipavirus nipahense Deng, Z., Kuang, W. 3 X-RAY DIFFRACTION 0.269 0.219 False True IGHV5 IGKV12 Kappa None None None None None 9lu3 D E 0 B protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/26/25 LN1F9 Fab bound to Nipah Virus attachment (G) glycoprotein head domain Henipavirus nipahense; Mus musculus mus musculus mus musculus henipavirus nipahense Deng, Z., Kuang, W. 3 X-RAY DIFFRACTION 0.269 0.219 False True IGHV5 IGKV12 Kappa None None None None None 9lue H L 0 G protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/26/25 Cryo-EM structure of the Nipah G head domain in complex with three Fabs Henipavirus nipahense; Mesocricetus auratus mesocricetus auratus mesocricetus auratus henipavirus nipahense Wang, Y., Deng, Z., Zhao, H. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 9lue A B 0 G protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/26/25 Cryo-EM structure of the Nipah G head domain in complex with three Fabs Henipavirus nipahense; Mesocricetus auratus mesocricetus auratus mesocricetus auratus henipavirus nipahense Wang, Y., Deng, Z., Zhao, H. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9lue C D 0 G protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/26/25 Cryo-EM structure of the Nipah G head domain in complex with three Fabs Henipavirus nipahense; Mesocricetus auratus mesocricetus auratus mesocricetus auratus henipavirus nipahense Wang, Y., Deng, Z., Zhao, H. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9me4 H L 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb475 and mAb824 bound to the adhesin protein FimH Escherichia coli; Escherichia coli K-12; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 9me4 I M 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb475 and mAb824 bound to the adhesin protein FimH Escherichia coli; Escherichia coli K-12; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9me5 H L 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb824 and mAb926 bound to the adhesin protein FimH Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 9me5 I M 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb824 and mAb926 bound to the adhesin protein FimH Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9me6 H L 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb21, mAb475, and mAb824 bound to the adhesin protein FimH Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 9me6 I M 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb21, mAb475, and mAb824 bound to the adhesin protein FimH Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9me6 J N 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb21, mAb475, and mAb824 bound to the adhesin protein FimH Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 9me7 I M 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb21 and mAb824 bound to the adhesin protein FimH containing alpha-methyl mannose Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9me7 J N 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragments from mAb21 and mAb824 bound to the adhesin protein FimH containing alpha-methyl mannose Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 9mr1 A B 0 C protein NA spike protein s2 VIRUS 11/26/25 SARS-CoV-2 S2 monomer in complex with R125-61 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, S., Bangaru, B., Ward, A.B. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV4 Kappa None None None None None 9mr2 A B 0 C protein NA spike protein s2 VIRUS 11/26/25 SARS-CoV-2 S2 monomer in complex with NICA01A-1401 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, S., Bangaru, B., Ward, A.B. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9ptm I M 0 A protein NA type 1 fimbrin d-mannose specific adhesin CELL ADHESION/IMMUNE SYSTEM 11/26/25 Antibody fragment from mAb824 bound to the adhesin protein FimH. Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hvorecny, K.L., Magala, P., Klevit, R.E., Kollman, J.M. 3.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9rsj H L 0 NA NA NA NA TRANSPORT PROTEIN 11/26/25 Cryo-EM structure of MATE transporter NorM-VC in complex with doxorubicin Lama glama; synthetic construct; Vibrio cholerae synthetic construct synthetic construct Romane, K., Hsieh, P.Y., Kowal, J., Locher, K.P., van Veen, H.W. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9rsj N NA 0 A protein NA multidrug resistance protein norm TRANSPORT PROTEIN 11/26/25 Cryo-EM structure of MATE transporter NorM-VC in complex with doxorubicin Lama glama; synthetic construct; Vibrio cholerae synthetic construct vibrio cholerae Romane, K., Hsieh, P.Y., Kowal, J., Locher, K.P., van Veen, H.W. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9rsj K NA 0 NA NA NA NA TRANSPORT PROTEIN 11/26/25 Cryo-EM structure of MATE transporter NorM-VC in complex with doxorubicin Lama glama; synthetic construct; Vibrio cholerae lama glama Romane, K., Hsieh, P.Y., Kowal, J., Locher, K.P., van Veen, H.W. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9umj H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of EP54 bound mouse C3aR in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, M.K., Yadav, R., Ganguly, M., Mishra, S., Dalal, A., Gati, C., Shukla, A.K. 3.38 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9umr H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of C5a-pep bound human C5aR1 in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Shukla, A.K. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9umx H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/26/25 Structure of EP54 bound human C5aR1 in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Banerjee, R., Yadav, M.K., Ganguly, M., Mishra, S., Dalal, A., Shukla, A.K. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9w6w E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/26/25 5-CT-bound serotonin 5A (5-HT5A) receptor-Gi protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, X., Xie, L., Chen, P., Yu, J., Tian, X., Wei, J., Shao, Z., Yan, W., Xu, Z. 3.13 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9wsv H L 0 C | R protein | protein NA | NA beta-arrestin-1 | mu-type opioid receptor,vasopressin v2 receptor MEMBRANE PROTEIN 11/26/25 Cryo-EM structure of DAMGO-muOR-arrestin-1-Fab30 complex Bos taurus; Homo sapiens; Mus musculus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct bos taurus | mus musculus, homo sapiens Zhang, H., Wang, X., Xi, K., Shen, Q., Xue, J., Zhu, Y., Yang, G., Zhang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9wsx H L 0 C | R protein | protein NA | NA beta-arrestin-1 | mu-type opioid receptor,vasopressin v2 receptor MEMBRANE PROTEIN 11/26/25 Cryo-EM structure of endomorphin-1-muOR-arrestin2-Fab30 complex Bos taurus; Homo sapiens; Mus musculus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct bos taurus | mus musculus, homo sapiens Zhang, H., Wang, X., Xi, K., Shen, Q., Xue, J., Zhu, Y., Yang, G., Zhang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9mte A NA 0 C protein NA receptor tyrosine-protein kinase erbb-2 TRANSFERASE/IMMUNE SYSTEM 11/19/25 CryoEM structure of extracellular domain of human HER2 complexed with two nano-bodies 27A05 and 47D05 Homo sapiens; Lama glama lama glama homo sapiens Bruch, E.M., Rak, A. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9mte B NA 0 C protein NA receptor tyrosine-protein kinase erbb-2 TRANSFERASE/IMMUNE SYSTEM 11/19/25 CryoEM structure of extracellular domain of human HER2 complexed with two nano-bodies 27A05 and 47D05 Homo sapiens; Lama glama lama glama homo sapiens Bruch, E.M., Rak, A. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9mtx A NA 0 B protein NA receptor protein-tyrosine kinase TRANSFERASE 11/19/25 CryoEM structure of extracellular domain of human HER2 complexed with nano-bodies 29E09 Homo sapiens; Lama glama lama glama homo sapiens Bruch, E.M., Rak, A. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uyh C c 0 A | R protein | protein NA | NA beta-arrestin-1 | chemerin-like receptor 2,vasopressin v2 receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 1) Escherichia phage EcSzw-2; Homo sapiens homo sapiens homo sapiens | homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9uyh B NA 0 A protein NA beta-arrestin-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 1) Escherichia phage EcSzw-2; Homo sapiens escherichia phage ecszw-2 homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uyi C c 0 A protein NA beta-arrestin-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 2) Escherichia phage EcSzw-2; Homo sapiens homo sapiens homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9uyi B NA 0 A | R protein | protein NA | NA beta-arrestin-1 | chemerin-like receptor 2,vasopressin v2 receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 2) Escherichia phage EcSzw-2; Homo sapiens escherichia phage ecszw-2 homo sapiens | homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uyj C c 0 A | R protein | protein NA | NA beta-arrestin-1 | chemerin-like receptor 2,vasopressin v2 receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 3) Escherichia phage EcSzw-2; Homo sapiens homo sapiens homo sapiens | homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9uyj B NA 0 A protein NA beta-arrestin-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 3) Escherichia phage EcSzw-2; Homo sapiens escherichia phage ecszw-2 homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uyl C c 0 A | R protein | protein NA | NA beta-arrestin-1 | chemerin-like receptor 2,vasopressin v2 receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 4) Escherichia phage EcSzw-2; Homo sapiens homo sapiens homo sapiens | homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9uyl B NA 0 A protein NA beta-arrestin-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 4) Escherichia phage EcSzw-2; Homo sapiens escherichia phage ecszw-2 homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uym C c 0 A protein NA beta-arrestin-2,beta-arrestin-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Composite map of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 2 Escherichia phage EcSzw-2; Homo sapiens homo sapiens homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9uym B NA 0 A | R protein | protein NA | NA beta-arrestin-2,beta-arrestin-1 | chemerin-like receptor 2,vasopressin v2 receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Composite map of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 2 Escherichia phage EcSzw-2; Homo sapiens escherichia phage ecszw-2 homo sapiens | homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uyn C c 0 A protein NA beta-arrestin-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to beta-arrestin 1 in ligand-free state Escherichia phage EcSzw-2; Homo sapiens homo sapiens homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9uyn B NA 0 A | R protein | protein NA | NA beta-arrestin-1 | chemerin-like receptor 2,vasopressin v2 receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to beta-arrestin 1 in ligand-free state Escherichia phage EcSzw-2; Homo sapiens escherichia phage ecszw-2 homo sapiens | homo sapiens Cai, H., Lin, X., Zhao, L., He, M., Yu, J., Zhang, B., Ma, Y., Xie, C., Shui, W., Zhao, Q., Zhu, Y., Wu, B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cf5 L K 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/19/25 STRUCTURE OF CD4 MIMETIC CJF-III-288 IN COMPLEX WITH BG505 SOSIP.664 HIV-1ENV TRIMER AND 17B FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Niu, L., Tolbert, W.D., Pazgier, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9cf5 J I 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/19/25 STRUCTURE OF CD4 MIMETIC CJF-III-288 IN COMPLEX WITH BG505 SOSIP.664 HIV-1ENV TRIMER AND 17B FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Niu, L., Tolbert, W.D., Pazgier, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9cf5 H G 0 E protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/19/25 STRUCTURE OF CD4 MIMETIC CJF-III-288 IN COMPLEX WITH BG505 SOSIP.664 HIV-1ENV TRIMER AND 17B FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Niu, L., Tolbert, W.D., Pazgier, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9hq5 B NA 0 A protein NA cd63 antigen CELL ADHESION 11/19/25 Crystal structure of Tetraspanin CD63mutant Large Extracellular Loop (LEL) in complex with sybody SB3 Homo sapiens; synthetic construct synthetic construct homo sapiens Nagarathinam, K., Krey, T. 2.6 X-RAY DIFFRACTION 0.292 0.245 False True IGHV1 NA NA None None None None None 9hub B C 0 X protein NA alpha-bungarotoxin TOXIN 11/19/25 D11 mAbs bound to alpha-Bungarotoxin at pH 7.5 Bungarus multicinctus; Homo sapiens homo sapiens homo sapiens bungarus multicinctus Wade, J.W., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.33 X-RAY DIFFRACTION 0.195 0.159 False True IGHV1 IGLV6 Lambda None None None None None 9hub I M 0 Z protein NA alpha-bungarotoxin TOXIN 11/19/25 D11 mAbs bound to alpha-Bungarotoxin at pH 7.5 Bungarus multicinctus; Homo sapiens homo sapiens homo sapiens bungarus multicinctus Wade, J.W., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.33 X-RAY DIFFRACTION 0.195 0.159 False True IGHV1 IGLV6 Lambda None None None None None 9huo I M 0 A protein NA alpha-cobratoxin TOXIN 11/19/25 A01 mAbs bound to cobratoxin at pH 5.5 Homo sapiens; Naja kaouthia homo sapiens homo sapiens naja kaouthia Wade, J.W., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.6 X-RAY DIFFRACTION 0.225 0.183 False True IGHV1 IGLV3 Lambda None None None None None 9huo C D 0 B protein NA alpha-cobratoxin TOXIN 11/19/25 A01 mAbs bound to cobratoxin at pH 5.5 Homo sapiens; Naja kaouthia homo sapiens homo sapiens naja kaouthia Wade, J.W., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.6 X-RAY DIFFRACTION 0.225 0.183 False True IGHV1 IGLV3 Lambda None None None None None 9hur B NA 0 A protein NA cd63 antigen CELL ADHESION 11/19/25 Crystal structure of Tetraspanin CD63mutant Large Extracellular Loop (LEL) in complex with sybody LA4 Homo sapiens; synthetic construct synthetic construct homo sapiens Nagarathinam, K., Krey, T. 1.65 X-RAY DIFFRACTION 0.238 0.211 False True IGHV1 NA NA None None None None None 9hxo I M 0 B protein NA alpha-cobratoxin TOXIN 11/19/25 A01 mAbs bound to cobratoxin at pH 6.0 Homo sapiens; Naja kaouthia homo sapiens homo sapiens naja kaouthia Wade, J.W., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.49 X-RAY DIFFRACTION 0.249 0.204 False True IGHV1 IGLV3 Lambda None None None None None 9hxo C D 0 A protein NA alpha-cobratoxin TOXIN 11/19/25 A01 mAbs bound to cobratoxin at pH 6.0 Homo sapiens; Naja kaouthia homo sapiens homo sapiens naja kaouthia Wade, J.W., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.49 X-RAY DIFFRACTION 0.249 0.204 False True IGHV1 IGLV3 Lambda None None None None None 9kkj H L 0 A protein NA nectin-4 IMMUNE SYSTEM 11/19/25 Structure of Nectin-4 D1 domain in complex with the Fab fragment of 9MW2821 mAb Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Wen, H.Y. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV4 Kappa None None None None None 9kmc E F 0 A protein NA interleukin-2 receptor subunit alpha IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 and anti-CD25 Fab S417 Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Katsura, K., Matsumoto, T., Shirouzu, M. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9kmp B NA 0 A protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP-HCAb1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kmp D NA 0 C protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP-HCAb1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kmp F NA 0 E protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP-HCAb1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kmp I NA 0 G protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP-HCAb1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kmp J NA 0 H protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP-HCAb1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kms D NA 0 C protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP antigen-antibody2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.j. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kms B NA 0 A protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP antigen-antibody2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.j. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kms F NA 0 E protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP antigen-antibody2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.j. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kms H NA 0 G protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP antigen-antibody2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.j. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kms J NA 0 I protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 CRP antigen-antibody2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.j. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9p92 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/19/25 Cryo-EM structure of the PAC1nR-VIP-Gs complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Piper, S.J., Lu, J., Sexton, P., Wootten, D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9p93 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/19/25 Cryo-EM structure of the PAC1sR-VIP-Gs complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Piper, S.J., Lu, J., Sexton, P., Wootten, D. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9p94 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/19/25 Cryo-EM structure of the PAC1sR-PACAP27-Gs complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Piper, S.J., Sexton, P., Wootten, D. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9pw4 C D 0 A protein NA spike protein s1 VIRAL PROTEIN 11/19/25 Structure of V30V4 in complex with SARS-CoV-2 spike Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y.J., Kibria, G., Wesemann, D., Chen, B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9pw4 E F 0 A protein NA spike protein s1 VIRAL PROTEIN 11/19/25 Structure of V30V4 in complex with SARS-CoV-2 spike Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.J., Kibria, G., Wesemann, D., Chen, B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9qt3 B C 0 A protein NA envelop protein opg153 VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve homo sapiens homo sapiens vaccinia virus western reserve Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV4 IGKV1 Kappa None None None None None 9qt3 F G 0 E protein NA envelop protein opg153 VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve homo sapiens homo sapiens vaccinia virus western reserve Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV4 IGKV1 Kappa None None None None None 9qt3 J K 0 I protein NA envelop protein opg153 VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve homo sapiens homo sapiens vaccinia virus western reserve Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV4 IGKV1 Kappa None None None None None 9qt3 N O 0 M protein NA envelop protein opg153 VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve homo sapiens homo sapiens vaccinia virus western reserve Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV4 IGKV1 Kappa None None None None None 9qt3 D NA 0 E protein NA envelop protein opg153 VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve lama glama vaccinia virus western reserve Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV1 NA NA None None None None None 9qt3 H NA 0 A protein NA envelop protein opg153 VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve lama glama vaccinia virus western reserve Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV1 NA NA None None None None None 9qt3 L NA 0 E protein NA envelop protein opg153 VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve lama glama vaccinia virus western reserve Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV1 NA NA None None None None None 9qt3 P NA 0 NA NA NA NA VIRAL PROTEIN 11/19/25 Structure of vaccinia virus A26 (residues 1-397) in complex with Fab 8M2110 Homo sapiens; Lama glama; Vaccinia virus Western Reserve lama glama Guardado-Calvo, P., Battini, L. 2.9 X-RAY DIFFRACTION 0.236 0.201 False True IGHV1 NA NA None None None None None 9v6o S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/19/25 Cryo-EM structure of human kappa opioid receptor - G protein signaling complex bound with nalfurafine. Homo sapiens homo sapiens homo sapiens | homo sapiens Suno-Ikeda, C., Takai, T., Hirose, M., Inoue, A., Sugita, Y., Kato, T., Kobayashi, T., Suno, R. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9vca H L 0 E protein NA c-reactive protein IMMUNE SYSTEM 11/19/25 Binding site between C-reactive protein and c2cc monoclonal antibody Homo sapiens; Mus musculus albula mus musculus albula mus musculus albula homo sapiens Moiseenko, A.V., Kalikin, A.V. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9vft F E 0 C | B | A protein | protein | protein NA | NA | NA genome polyprotein | genome polyprotein | genome polyprotein VIRUS 11/19/25 Structure of mature CVA6 virus complexed with 3H7 Fab Coxsackievirus A6; Mus musculus mus musculus mus musculus coxsackievirus a6 | coxsackievirus a6 | coxsackievirus a6 Ke, X., Li, X., Liu, Z., Liu, K., Yan, X., Shu, B., Zhang, C. 2.59 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV9 Kappa None None None None None 9vfu E F 0 A | B | C protein | protein | protein NA | NA | NA genome polyprotein | genome polyprotein | genome polyprotein VIRUS 11/19/25 Structure of mature CVA6 virus complexed with 1F4 Fab Coxsackievirus A6; Mus musculus mus musculus mus musculus coxsackievirus a6 | coxsackievirus a6 | coxsackievirus a6 Ke, X., Li, X., Liu, Z., Liu, K., Yan, X., Shu, B., Zhang, C. 2.11 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 9vg1 E D 0 B | C | A protein | protein | protein NA | NA | NA genome polyprotein | genome polyprotein | genome polyprotein VIRUS 11/19/25 Structure of CVA6 empty capsid complexed with 3H7 Fab Coxsackievirus A6; Mus musculus mus musculus mus musculus coxsackievirus a6 | coxsackievirus a6 | coxsackievirus a6 Ke, X., Li, X., Liu, Z., Liu, K., Yan, X., Shu, B., Zhang, C. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV9 Kappa None None None None None 9wxm D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/25 Cryo-EM structure of the full-length GPR15L bound GPR15-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Han, S., Wu, B., Zhao, Q. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9x1h H L 0 A protein NA complement c1s subcomponent heavy chain IMMUNE SYSTEM 11/19/25 Cryo-EM Structure of human complement C1s CUB domain in complex with RAY121 Homo sapiens homo sapiens homo sapiens homo sapiens Kawauchi, H., Adrian, H., Gupta, G., Koga, H., Fujii, T., Fukumura, T., Ishino, S., Irie, M., Torizawa, T. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9x1h I M 0 B protein NA complement c1s subcomponent heavy chain IMMUNE SYSTEM 11/19/25 Cryo-EM Structure of human complement C1s CUB domain in complex with RAY121 Homo sapiens homo sapiens homo sapiens homo sapiens Kawauchi, H., Adrian, H., Gupta, G., Koga, H., Fujii, T., Fukumura, T., Ishino, S., Irie, M., Torizawa, T. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9ydu E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/19/25 UDPG bound P2Y14 Receptor in complex with Gi Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Fay, J.F. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9n5y I L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/12/25 Hemagglutinin CA09 homotrimer bound to AEL31302/AEL31311 Fab Homo sapiens; Influenza A virus (A/California/01/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/01/2009(h1n1)) | influenza a virus (a/california/01/2009(h1n1)) Fernandez-Quintero, M.L., Turner, H.L. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9n5y P O 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/12/25 Hemagglutinin CA09 homotrimer bound to AEL31302/AEL31311 Fab Homo sapiens; Influenza A virus (A/California/01/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/01/2009(h1n1)) | influenza a virus (a/california/01/2009(h1n1)) Fernandez-Quintero, M.L., Turner, H.L. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9n5y J M 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/12/25 Hemagglutinin CA09 homotrimer bound to AEL31302/AEL31311 Fab Homo sapiens; Influenza A virus (A/California/01/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/01/2009(h1n1)) | influenza a virus (a/california/01/2009(h1n1)) Fernandez-Quintero, M.L., Turner, H.L. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9nh7 E NA 0 H | B protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain DE NOVO PROTEIN 11/12/25 CryoEM Structure of De Novo VHH, VHH_flu_01, bound to influenza HA, strain A/USA:Iowa/1943 H1N1. Influenza A virus (strain A/USA:Iowa/1943 H1N1); synthetic construct synthetic construct influenza a virus (strain a/usah1n1) | influenza a virus (strain a/usah1n1) Borst, A.J., Weidle, C. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9nh7 F NA 0 G | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain DE NOVO PROTEIN 11/12/25 CryoEM Structure of De Novo VHH, VHH_flu_01, bound to influenza HA, strain A/USA:Iowa/1943 H1N1. Influenza A virus (strain A/USA:Iowa/1943 H1N1); synthetic construct synthetic construct influenza a virus (strain a/usah1n1) | influenza a virus (strain a/usah1n1) Borst, A.J., Weidle, C. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9h8h A D 0 NA NA NA NA IMMUNE SYSTEM 11/12/25 Structure of DC11 anti tau antibody Fab fragment Mus mus mus Cehlar, O., Njemoga, S. 1.331 X-RAY DIFFRACTION 0.196 0.145 False True IGHV14 IGKV1 Kappa None None None None None 9i5e M NA 0 A protein NA isoform 2b of gtpase kras,aph2 STRUCTURAL PROTEIN 11/12/25 A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery Homo sapiens; Lama glama lama glama homo sapiens Samson, C., Dossou, I., Steinmetz, A., Kumar, A., Mathieu, M., Rak, A. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9i5e N NA 0 B protein NA isoform 2b of gtpase kras,aph2 STRUCTURAL PROTEIN 11/12/25 A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery Homo sapiens; Lama glama lama glama homo sapiens Samson, C., Dossou, I., Steinmetz, A., Kumar, A., Mathieu, M., Rak, A. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9k94 H NA 0 C protein NA c-reactive protein IMMUNE SYSTEM 11/12/25 CRP-HCAb2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9k94 B NA 0 A protein NA c-reactive protein IMMUNE SYSTEM 11/12/25 CRP-HCAb2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9k94 E NA 0 D protein NA c-reactive protein IMMUNE SYSTEM 11/12/25 CRP-HCAb2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9k94 G NA 0 F protein NA c-reactive protein IMMUNE SYSTEM 11/12/25 CRP-HCAb2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9k94 J NA 0 I protein NA c-reactive protein IMMUNE SYSTEM 11/12/25 CRP-HCAb2 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kft S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PEPTIDE BINDING PROTEIN 11/12/25 Cryo-EM structure of the fMLFC-FPR1-Gi complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Chen, G., Wang, J., Ye, R.D. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kfw A NA 19 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 18 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 17 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 16 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 15 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 14 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 13 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 12 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 11 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 10 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 9 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 8 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 7 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 6 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 5 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 4 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 3 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 2 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 1 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9kfw A NA 0 NA NA NA NA PROTEIN BINDING 11/12/25 NMR structure of an agonistic OX40 nanobody Vicugna pacos vicugna pacos Nagata, T., Kobayashi, N., Iemura, T., Kitawaki, T., Maeda, R., Nagata, K., Yamazaki, K., Shirakawa, K., Imura, A., Takaori-Kondo, A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 9m5d D NA 0 H protein NA immunoglobulin g-binding protein a IMMUNE SYSTEM 11/12/25 Crystal structure of S. aureus protein A bound to a human single-domain antibody Homo sapiens; Staphylococcus aureus (strain NCTC 8325 / PS 47) homo sapiens staphylococcus aureus (strain nctc 8325 / ps47) Kong, Y., Shi, J.L., Ying, T.L., Yang, Z.L., Xu, Q.Y. 3.57 X-RAY DIFFRACTION 0.271 0.233 False True IGHV3 NA NA None None None None None 9m5d A NA 0 NA NA NA NA IMMUNE SYSTEM 11/12/25 Crystal structure of S. aureus protein A bound to a human single-domain antibody Homo sapiens; Staphylococcus aureus (strain NCTC 8325 / PS 47) homo sapiens Kong, Y., Shi, J.L., Ying, T.L., Yang, Z.L., Xu, Q.Y. 3.57 X-RAY DIFFRACTION 0.271 0.233 False True IGHV3 NA NA None None None None None 9m6j A NA 0 H protein NA immunoglobulin g-binding protein a IMMUNE SYSTEM 11/12/25 Crystal structure of S. aureus protein A bound to a camelid single-domain antibody Camelidae; Staphylococcus aureus subsp. aureus NCTC 8325 camelidae staphylococcus aureus subsp. aureus nctc 8325 Kong, Y., Shi, J.L., Wu, F.D., Zhao, T., Zhu, X.Y., Xu, Q.Y., Wang, R.B., Song, Y.D., Li, Q.X., Wang, Y.L., Gao, X.Y., Yang, Y.D., Wu, Y.L., Yang, Z.L., Yao, J.H., Ying, T.L. 2 X-RAY DIFFRACTION 0.226 0.192 False True IGHV1 NA NA None None None None None 9m6o B NA 0 A protein NA immunoglobulin g-binding protein a IMMUNE SYSTEM 11/12/25 Crystal structure of S. aureus protein A bound to a camelid single-domain antibody Camelus dromedarius; Staphylococcus aureus (strain NCTC 8325 / PS 47) camelus dromedarius staphylococcus aureus (strain nctc 8325 / ps47) Kong, Y., Shi, J.L., Wu, F.D., Zhao, T., Zhu, X.Y., Xu, Q.Y., Wang, R.B., Song, Y.D., Li, Q.X., Wang, Y.L., Gao, X.Y., Yang, Y.D., Wu, Y.L., Yang, Z.L., Yao, J.H., Ying, T.L. 1.49 X-RAY DIFFRACTION 0.257 0.224 False True IGHV1 NA NA None None None None None 9m6o C NA 0 H protein NA immunoglobulin g-binding protein a IMMUNE SYSTEM 11/12/25 Crystal structure of S. aureus protein A bound to a camelid single-domain antibody Camelus dromedarius; Staphylococcus aureus (strain NCTC 8325 / PS 47) camelus dromedarius staphylococcus aureus (strain nctc 8325 / ps47) Kong, Y., Shi, J.L., Wu, F.D., Zhao, T., Zhu, X.Y., Xu, Q.Y., Wang, R.B., Song, Y.D., Li, Q.X., Wang, Y.L., Gao, X.Y., Yang, Y.D., Wu, Y.L., Yang, Z.L., Yao, J.H., Ying, T.L. 1.49 X-RAY DIFFRACTION 0.257 0.224 False True IGHV1 NA NA None None None None None 9n5z A B 0 C protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/12/25 Hemagglutinin CA09 homotrimer bound to AMB38310/AMB38599 Fab Homo sapiens; Influenza A virus (A/California/01/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/01/2009(h1n1)) Fernandez-Quintero, M.L., Raghavan, S.S.R., Gharpure, A., Turner, H.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9nfu C c 0 A protein NA toxin b DE NOVO PROTEIN 11/12/25 CryoEM Structure of De Novo Antibody Fragment scFv 6 with C. difficile Toxin B (TcdB) Clostridioides difficile; synthetic construct synthetic construct clostridioides difficile Weidle, C., Borst, A.J. 3.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9nq3 H L 0 NA NA NA NA IMMUNE SYSTEM 11/12/25 Crystal structure of SARS-CoV-2 S2 directed Fab 1871 Homo sapiens homo sapiens homo sapiens Muthuraman, K., Ivanochko, D., Julien, J.P. 2.5 X-RAY DIFFRACTION 0.251 0.216 False True IGHV3 IGKV3 Kappa None None None None None 9nq3 A B 0 NA NA NA NA IMMUNE SYSTEM 11/12/25 Crystal structure of SARS-CoV-2 S2 directed Fab 1871 Homo sapiens homo sapiens homo sapiens Muthuraman, K., Ivanochko, D., Julien, J.P. 2.5 X-RAY DIFFRACTION 0.251 0.216 False True IGHV3 IGKV3 Kappa None None None None None 9nqz E D 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/12/25 cryo-EM structure of broad betacoronavirus binding antibody 1871 in complex with OC43 S2 subunit Homo sapiens; Human coronavirus OC43 homo sapiens homo sapiens human coronavirus oc43 Muthuraman, K., Jackman, M.J., Julien, J.P. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9nqz G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/12/25 cryo-EM structure of broad betacoronavirus binding antibody 1871 in complex with OC43 S2 subunit Homo sapiens; Human coronavirus OC43 homo sapiens homo sapiens human coronavirus oc43 Muthuraman, K., Jackman, M.J., Julien, J.P. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9nqz H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/12/25 cryo-EM structure of broad betacoronavirus binding antibody 1871 in complex with OC43 S2 subunit Homo sapiens; Human coronavirus OC43 homo sapiens homo sapiens human coronavirus oc43 Muthuraman, K., Jackman, M.J., Julien, J.P. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9oog H L 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/12/25 Cryo-EM structure of vaccine-elicited antibody T3_NB_G05 in complex with HIV Env trimer Q23-APEX-GT1.N187S Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oog I M 0 d protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/12/25 Cryo-EM structure of vaccine-elicited antibody T3_NB_G05 in complex with HIV Env trimer Q23-APEX-GT1.N187S Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oog J N 0 f protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/12/25 Cryo-EM structure of vaccine-elicited antibody T3_NB_G05 in complex with HIV Env trimer Q23-APEX-GT1.N187S Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oom H L 0 b protein NA unknown VIRAL PROTEIN 11/12/25 Cryo-EM structure of vaccine-elicited antibody T6_P_H03 in complex with HIV Env trimer Q23-APEX-GT1 Human immunodeficiency virus type 1; Mus musculus mus musculus mus musculus human immunodeficiency virus type 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oom I M 0 d protein NA unknown VIRAL PROTEIN 11/12/25 Cryo-EM structure of vaccine-elicited antibody T6_P_H03 in complex with HIV Env trimer Q23-APEX-GT1 Human immunodeficiency virus type 1; Mus musculus mus musculus mus musculus human immunodeficiency virus type 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oom J N 0 f protein NA unknown VIRAL PROTEIN 11/12/25 Cryo-EM structure of vaccine-elicited antibody T6_P_H03 in complex with HIV Env trimer Q23-APEX-GT1 Human immunodeficiency virus type 1; Mus musculus mus musculus mus musculus human immunodeficiency virus type 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9p4c H L 0 M peptide NA mesothelin, cleaved form ANTITUMOR PROTEIN 11/12/25 Crystal structure of Mesothelin C-terminal peptide-RO4 Fab complex Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Zhan, J., Maslanka, C., Xia, D. 1.52 X-RAY DIFFRACTION 0.180 0.149 False True IGHV1 IGKV1 Kappa None None None None None 9pym B NA 0 A protein NA isethionate trap transporter permease protein dctmq TRANSPORT PROTEIN 11/12/25 Cryo-EM structure of the isethionate TRAP transporter IseQM from Oleidesulfovibrio alaskensis with bound isethionate Helicobacter pylori; Oleidesulfovibrio alaskensis G20 helicobacter pylori oleidesulfovibrio alaskensis g20 Newton-Vesty, M.C., Davies, J.S., Dobson, R.C.J. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9vje E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/12/25 Cryo-EM structure of 5-HT1AR-GoA in complex with buspirone Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wang, C., Cao, C. 2.47 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9vjf E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/12/25 Cryo-EM structure of 5-HT1AR-Gi3 in complex with buspirone Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wang, C., Cao, C. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9bop A B 0 S protein NA virion spike glycoprotein gp1 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 A broadly-neutralizing antibody against Ebolavirus glycoprotein that can potentiate the breadth and neutralization potency of other anti-glycoprotein antibodies Ebolavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus ebolavirus Donnellan, F.R., Rayaprolu, V., Rijal, P., O'Dowd, V., Parvate, A., Callaway, H., Hariharan, C., Parekh, D., Hui, S., Shaffer, K., Hastie, K., Shimanski, L., Muller-Krauter, H., Stecker, T., Balaram, A., Halfmann, P., Saphire, E.O., Lightwood, D.J., Townsend, A.R., Draper, S.J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9bop M N 0 S | V protein | protein NA | NA virion spike glycoprotein gp1 | virion spike glycoprotein gp2 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 A broadly-neutralizing antibody against Ebolavirus glycoprotein that can potentiate the breadth and neutralization potency of other anti-glycoprotein antibodies Ebolavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus ebolavirus | ebolavirus Donnellan, F.R., Rayaprolu, V., Rijal, P., O'Dowd, V., Parvate, A., Callaway, H., Hariharan, C., Parekh, D., Hui, S., Shaffer, K., Hastie, K., Shimanski, L., Muller-Krauter, H., Stecker, T., Balaram, A., Halfmann, P., Saphire, E.O., Lightwood, D.J., Townsend, A.R., Draper, S.J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9bop O P 0 T | W protein | protein NA | NA virion spike glycoprotein gp1 | virion spike glycoprotein gp2 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 A broadly-neutralizing antibody against Ebolavirus glycoprotein that can potentiate the breadth and neutralization potency of other anti-glycoprotein antibodies Ebolavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus ebolavirus | ebolavirus Donnellan, F.R., Rayaprolu, V., Rijal, P., O'Dowd, V., Parvate, A., Callaway, H., Hariharan, C., Parekh, D., Hui, S., Shaffer, K., Hastie, K., Shimanski, L., Muller-Krauter, H., Stecker, T., Balaram, A., Halfmann, P., Saphire, E.O., Lightwood, D.J., Townsend, A.R., Draper, S.J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9bop C D 0 T protein NA virion spike glycoprotein gp1 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 A broadly-neutralizing antibody against Ebolavirus glycoprotein that can potentiate the breadth and neutralization potency of other anti-glycoprotein antibodies Ebolavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus ebolavirus Donnellan, F.R., Rayaprolu, V., Rijal, P., O'Dowd, V., Parvate, A., Callaway, H., Hariharan, C., Parekh, D., Hui, S., Shaffer, K., Hastie, K., Shimanski, L., Muller-Krauter, H., Stecker, T., Balaram, A., Halfmann, P., Saphire, E.O., Lightwood, D.J., Townsend, A.R., Draper, S.J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9bop E F 0 U protein NA virion spike glycoprotein gp1 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 A broadly-neutralizing antibody against Ebolavirus glycoprotein that can potentiate the breadth and neutralization potency of other anti-glycoprotein antibodies Ebolavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus ebolavirus Donnellan, F.R., Rayaprolu, V., Rijal, P., O'Dowd, V., Parvate, A., Callaway, H., Hariharan, C., Parekh, D., Hui, S., Shaffer, K., Hastie, K., Shimanski, L., Muller-Krauter, H., Stecker, T., Balaram, A., Halfmann, P., Saphire, E.O., Lightwood, D.J., Townsend, A.R., Draper, S.J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9h77 A NA 0 C protein NA m-phase phosphoprotein 8 GENE REGULATION 11/05/25 MPP8 chromodomain in complex with nanobody 3A02 Homo sapiens; Lama glama lama glama homo sapiens Richards, M.W., Bayliss, R. 2.01 X-RAY DIFFRACTION 0.281 0.253 False True IGHV3 NA NA None None None None None 9h77 B NA 0 D protein NA m-phase phosphoprotein 8 GENE REGULATION 11/05/25 MPP8 chromodomain in complex with nanobody 3A02 Homo sapiens; Lama glama lama glama homo sapiens Richards, M.W., Bayliss, R. 2.01 X-RAY DIFFRACTION 0.281 0.253 False True IGHV3 NA NA None None None None None 9mq1 H L 0 A | B protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 Cryo-EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 20D10 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Leon, A.N., Brouwer, P.J.M., Rodriguez, A.J., Han, J., Ward, A.B. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9mq2 H L 0 B | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 Cryo-EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 12G1 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Leon, A.N., Brouwer, P.J.M., Rodriguez, A.J., Han, J., Ward, A.B. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9mq3 H L 0 A | B protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 Cryo-EM map of H5 HA (A/Jiangsu/NJ210/2023) in complex with monoclonal fab 6G1 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Leon, A.N., Brouwer, P.J.M., Rodriguez, A.J., Han, J., Ward, A.B. 3.22 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV2 Kappa None None None None None 9omg H L 0 A protein NA hiv env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 Cryo-EM structure of rhesus antibody V033-a.I1 in complex with HIV Env trimer Q23.17 MD39 Homo sapiens; Macaca mulatta macaca mulatta macaca mulatta homo sapiens Roark, R.S., Shapiro, L., Kwong, P.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ook H L 0 h protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 Cryo-EM structure of vaccine-elicited antibody T3_QB_G12 in complex with HIV Env trimer Q23-APEX-GT1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9ook I M 0 j protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 Cryo-EM structure of vaccine-elicited antibody T3_QB_G12 in complex with HIV Env trimer Q23-APEX-GT1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9ook J N 0 f protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/05/25 Cryo-EM structure of vaccine-elicited antibody T3_QB_G12 in complex with HIV Env trimer Q23-APEX-GT1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9puk A B 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Neutralizing monoclonal antibody Fab fragment for human leptin Homo sapiens homo sapiens homo sapiens Tomchick, D.R., Wynn, R.M., Scherer, P.E. 3.3 X-RAY DIFFRACTION 0.320 0.267 False True IGHV1 IGLV1 Lambda None None None None None 9puk C D 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Neutralizing monoclonal antibody Fab fragment for human leptin Homo sapiens homo sapiens homo sapiens Tomchick, D.R., Wynn, R.M., Scherer, P.E. 3.3 X-RAY DIFFRACTION 0.320 0.267 False True IGHV1 IGLV1 Lambda None None None None None 9puo A B 0 C protein NA leptin IMMUNE SYSTEM 11/05/25 Neutralizing monoclonal antibody Fab fragment bound to leptin Homo sapiens homo sapiens homo sapiens homo sapiens Tomchick, D.R., Wynn, R.M., Scherer, P.E. 3.1 X-RAY DIFFRACTION 0.277 0.236 False True IGHV1 IGLV1 Lambda None None None None None 9puo D E 0 F protein NA leptin IMMUNE SYSTEM 11/05/25 Neutralizing monoclonal antibody Fab fragment bound to leptin Homo sapiens homo sapiens homo sapiens homo sapiens Tomchick, D.R., Wynn, R.M., Scherer, P.E. 3.1 X-RAY DIFFRACTION 0.277 0.236 False True IGHV1 IGLV1 Lambda None None None None None 9qzq H L 0 NA NA NA NA TRANSPORT PROTEIN 11/05/25 CryoEM structure of nanodisc-reconstituted human NTCP in complex with grafted NTCP_Nb1 and NabFab Homo sapiens; Vicugna pacos homo sapiens homo sapiens Yoon, D., Nosol, K., Rasouli, A., Bang-Soerensen, R., Irobalieva, R.N., Liu, H., Tajkhorshid, E., Locher, K.P. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9qzq N NA 0 A protein NA sodium/bile acid cotransporter TRANSPORT PROTEIN 11/05/25 CryoEM structure of nanodisc-reconstituted human NTCP in complex with grafted NTCP_Nb1 and NabFab Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Yoon, D., Nosol, K., Rasouli, A., Bang-Soerensen, R., Irobalieva, R.N., Liu, H., Tajkhorshid, E., Locher, K.P. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9r10 H L 0 A protein NA multidrug and toxin extrusion protein 1 TRANSPORT PROTEIN 11/05/25 Cryo-EM structure of human MATE1 in complex with cimetidine Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Romane, K., Peteani, G., Mukherjee, S., Kowal, J., Rossi, L., Hou, J., Kossiakoff, A., Lemmin, T., Locher, K.P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9r1e H L 0 A protein NA multidrug and toxin extrusion protein 1 TRANSPORT PROTEIN 11/05/25 Cryo-EM structure of human MATE1 in complex with MPP Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Romane, K., Peteani, G., Mukherjee, S., Kowal, J., Rossi, L., Hou, J., Kossiakoff, A., Lemmin, T., Locher, K.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9r1f H L 0 A protein NA multidrug and toxin extrusion protein 1 TRANSPORT PROTEIN 11/05/25 Cryo-EM structure of human MATE1 in complex with metformin Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Romane, K., Peteani, G., Mukherjee, S., Kowal, J., Rossi, L., Hou, J., Kossiakoff, A., Lemmin, T., Locher, K.P. 2.31 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9r1g H L 0 A protein NA multidrug and toxin extrusion protein 1 TRANSPORT PROTEIN 11/05/25 Cryo-EM structure of human MATE1 Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Romane, K., Peteani, G., Mukherjee, S., Kowal, J., Rossi, L., Hou, J., Kossiakoff, A., Lemmin, T., Locher, K.P. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9rit A NA 0 C protein NA cytotoxin 1 TOXIN 11/05/25 Co-crystal of broadly neutralizing biparatopic VHH in complex with cardiotoxin (P01468) Naja pallida Naja pallida; Vicugna pacos vicugna pacos naja pallida Burlet, N.J., Laustsen, A.H., Morth, J.P. 1.6 X-RAY DIFFRACTION 0.258 0.222 False True IGHV1 NA NA None None None None None 9rit B NA 0 D protein NA cytotoxin 1 TOXIN 11/05/25 Co-crystal of broadly neutralizing biparatopic VHH in complex with cardiotoxin (P01468) Naja pallida Naja pallida; Vicugna pacos vicugna pacos naja pallida Burlet, N.J., Laustsen, A.H., Morth, J.P. 1.6 X-RAY DIFFRACTION 0.258 0.222 False True IGHV1 NA NA None None None None None 9riu A NA 0 B protein NA short neurotoxin 1 TOXIN 11/05/25 Co-crystal of broadly neutralizing VHH in complex with short neurotoxin 1 (P01426) Naja pallida Naja pallida; Vicugna pacos vicugna pacos naja pallida Burlet, N.J., Laustsen, A.H., Morth, J.P. 2.5 X-RAY DIFFRACTION 0.361 0.324 False True unknown unknown unknown None None None None None 9riu C NA 0 D protein NA short neurotoxin 1 TOXIN 11/05/25 Co-crystal of broadly neutralizing VHH in complex with short neurotoxin 1 (P01426) Naja pallida Naja pallida; Vicugna pacos vicugna pacos naja pallida Burlet, N.J., Laustsen, A.H., Morth, J.P. 2.5 X-RAY DIFFRACTION 0.361 0.324 False True unknown unknown unknown None None None None None 9udn A a 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Single-chain Fv antibody of F8 Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.81 X-RAY DIFFRACTION 0.220 0.180 True True unknown unknown unknown None None None None None 9udp A a 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Single-chain Fv antibody of B2 Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.48 X-RAY DIFFRACTION 0.174 0.156 True True unknown unknown unknown None None None None None 9uds A a 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Single-chain Fv antibody of C6 Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.99 X-RAY DIFFRACTION 0.215 0.179 True True unknown unknown unknown None None None None None 9uds B b 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Single-chain Fv antibody of C6 Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.99 X-RAY DIFFRACTION 0.215 0.179 True True unknown unknown unknown None None None None None 9uds C c 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Single-chain Fv antibody of C6 Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.99 X-RAY DIFFRACTION 0.215 0.179 True True unknown unknown unknown None None None None None 9uds D d 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 Single-chain Fv antibody of C6 Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.99 X-RAY DIFFRACTION 0.215 0.179 True True unknown unknown unknown None None None None None 9vuz NA A 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 an engineered light chain single-domain antibody targeting at mouse CD16 Homo sapiens homo sapiens Wang, M.K., Xu, Q.Y., Yang, Z.L., Ying, T.L., Wu, Y.L. 3.05 X-RAY DIFFRACTION 0.347 0.287 False True NA IGKV3 Kappa None None None None None 9vuz NA B 0 NA NA NA NA IMMUNE SYSTEM 11/05/25 an engineered light chain single-domain antibody targeting at mouse CD16 Homo sapiens homo sapiens Wang, M.K., Xu, Q.Y., Yang, Z.L., Ying, T.L., Wu, Y.L. 3.05 X-RAY DIFFRACTION 0.347 0.287 False True NA IGKV3 Kappa None None None None None 9mkn H L 0 B protein NA fusion glycoprotein f1 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the Respiratory Syncytial Virus Fusion Protein Bound to Human Antibodies RSV_2245 and RSV_3301 Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus Johnson, N.V., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9mkn I M 0 D protein NA fusion glycoprotein f1 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the Respiratory Syncytial Virus Fusion Protein Bound to Human Antibodies RSV_2245 and RSV_3301 Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus Johnson, N.V., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9mkn J N 0 F protein NA fusion glycoprotein f1 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the Respiratory Syncytial Virus Fusion Protein Bound to Human Antibodies RSV_2245 and RSV_3301 Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus Johnson, N.V., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9mkn O P 0 B | A protein | protein NA | NA fusion glycoprotein f1 | fusion glycoprotein f2 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the Respiratory Syncytial Virus Fusion Protein Bound to Human Antibodies RSV_2245 and RSV_3301 Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus | respiratory syncytial virus Johnson, N.V., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 9mkn Q R 0 D | C protein | protein NA | NA fusion glycoprotein f1 | fusion glycoprotein f2 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the Respiratory Syncytial Virus Fusion Protein Bound to Human Antibodies RSV_2245 and RSV_3301 Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus | respiratory syncytial virus Johnson, N.V., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 9mkn S T 0 F | E protein | protein NA | NA fusion glycoprotein f1 | fusion glycoprotein f2 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the Respiratory Syncytial Virus Fusion Protein Bound to Human Antibodies RSV_2245 and RSV_3301 Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus | respiratory syncytial virus Johnson, N.V., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8z8a S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/29/25 Cryo-EM structure of the Lactate-bound human HCAR1-Gi1 complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Gao, M., Zang, S., Zhu, Y., Mao, C., Zhang, Y., Ma, X. 2.82 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8z8b S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/29/25 Cryo-EM structure of human HCAR1-Gi complex without ligand (apo state) Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Gao, M., Zang, S., Zhu, Y., Mao, C., Zhang, Y., Ma, X. 2.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9e2a N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 10/29/25 Glucagon Like Peptide Receptor-1 (GLP1R) A316T mutant with GLP-1 peptide. Dominant negative Gs complex. Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Deane-Alder, K., Belousoff, M.J., Wootten, D.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9eyd B NA 0 A protein NA lysine-specific permease MEMBRANE PROTEIN 10/29/25 Cryo-EM structure of Pseudomonas aeruginosa lysine-specific permenase (LysP). Lama glama; Pseudomonas aeruginosa PAO1 lama glama pseudomonas aeruginosa pao1 Nji, E., Matsuoka, R. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eze B C 0 A protein NA duffy receptor CELL ADHESION 10/29/25 Structure of subdomain 3 of the Plasmodium vivx Duffy binding protein (PvDBP) bound to human antibody DB9 Homo sapiens; Plasmodium vivax Sal-1 homo sapiens homo sapiens plasmodium vivax sal-1 Barber, N.M., Higgins, M.K. 1.55 X-RAY DIFFRACTION 0.223 0.204 False True IGHV4 IGKV1 Kappa None None None None None 9eze E F 0 D protein NA duffy receptor CELL ADHESION 10/29/25 Structure of subdomain 3 of the Plasmodium vivx Duffy binding protein (PvDBP) bound to human antibody DB9 Homo sapiens; Plasmodium vivax Sal-1 homo sapiens homo sapiens plasmodium vivax sal-1 Barber, N.M., Higgins, M.K. 1.55 X-RAY DIFFRACTION 0.223 0.204 False True IGHV4 IGKV1 Kappa None None None None None 9ezh B NA 0 A protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of single-domain antibody VHH_h4 in complex with human Vsig4 Camelidae; Homo sapiens camelidae homo sapiens Vizarraga, D., Cianferoni, D., Delgado, J., van der Kant, R., Garcia, T., Maragkou, K., Zhang, Z., Dewilde, M., Schymkowitz, J., Rousseau, F., Serrano, L. 1.94 X-RAY DIFFRACTION 0.239 0.194 False True IGHV1 NA NA None None None None None 9ezi B NA 0 A protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of single-domain antibody VHH_h5 in complex with human Vsig4 Camelidae; Homo sapiens camelidae homo sapiens Vizarraga, D., Cianferoni, D., Delgado, J., van der Kant, R., Garcia, T., Maragkou, K., Zhang, Z., Dewilde, M., Schymkowitz, J., Rousseau, F., Serrano, L. 1.97 X-RAY DIFFRACTION 0.243 0.198 False True IGHV1 NA NA None None None None None 9ezu B NA 0 A protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of the single-domain antibody VHH_h1 in complex with human Vsig4 Camelidae; Homo sapiens camelidae homo sapiens Markovic, I., Savvides, S.N. 1.05 X-RAY DIFFRACTION 0.176 0.157 False True IGHV1 NA NA None None None None None 9ezv B NA 0 A protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of the single-domain antibody VHH_h2 in complex with human Vsig4 Homo sapiens homo sapiens homo sapiens Markovic, I., Savvides, S.N. 1.45 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 NA NA None None None None None 9ezw B NA 0 A protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of the single-domain antibody VHH_h3 in complex with human Vsig4 Homo sapiens homo sapiens homo sapiens Markovic, I., Savvides, S.N. 1.9 X-RAY DIFFRACTION 0.228 0.190 False True IGHV1 NA NA None None None None None 9ezw D NA 0 C protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of the single-domain antibody VHH_h3 in complex with human Vsig4 Homo sapiens homo sapiens homo sapiens Markovic, I., Savvides, S.N. 1.9 X-RAY DIFFRACTION 0.228 0.190 False True IGHV1 NA NA None None None None None 9ezw F NA 0 E protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of the single-domain antibody VHH_h3 in complex with human Vsig4 Homo sapiens homo sapiens homo sapiens Markovic, I., Savvides, S.N. 1.9 X-RAY DIFFRACTION 0.228 0.190 False True IGHV1 NA NA None None None None None 9ezw H NA 0 G protein NA v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 10/29/25 Structure of the single-domain antibody VHH_h3 in complex with human Vsig4 Homo sapiens homo sapiens homo sapiens Markovic, I., Savvides, S.N. 1.9 X-RAY DIFFRACTION 0.228 0.190 False True IGHV1 NA NA None None None None None 9h01 B NA 0 A protein NA guanine-n7 methyltransferase nsp14 VIRAL PROTEIN 10/29/25 nsp14 of SARS-CoV-2 in complex with a camelid nanobody Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Gauffre, P., Ferron, F., Canard, B. 2.533 X-RAY DIFFRACTION 0.290 0.243 False True IGHV1 NA NA None None None None None 9h1j A NA 0 E peptide NA sequestosome-1 PROTEIN TRANSPORT 10/29/25 Crystal structure of the p62 UBA domain bound to VHH 6C10 Homo sapiens; Lama glama lama glama homo sapiens Gutmann, S., Villard, F. 1.73 X-RAY DIFFRACTION 0.247 0.214 False False IGHV5 NA NA None None None None None 9h1j B NA 0 F peptide NA sequestosome-1 PROTEIN TRANSPORT 10/29/25 Crystal structure of the p62 UBA domain bound to VHH 6C10 Homo sapiens; Lama glama lama glama homo sapiens Gutmann, S., Villard, F. 1.73 X-RAY DIFFRACTION 0.247 0.214 False False IGHV5 NA NA None None None None None 9h1j C NA 0 G peptide NA sequestosome-1 PROTEIN TRANSPORT 10/29/25 Crystal structure of the p62 UBA domain bound to VHH 6C10 Homo sapiens; Lama glama lama glama homo sapiens Gutmann, S., Villard, F. 1.73 X-RAY DIFFRACTION 0.247 0.214 False False IGHV5 NA NA None None None None None 9h1j D NA 0 H peptide NA sequestosome-1 PROTEIN TRANSPORT 10/29/25 Crystal structure of the p62 UBA domain bound to VHH 6C10 Homo sapiens; Lama glama lama glama homo sapiens Gutmann, S., Villard, F. 1.73 X-RAY DIFFRACTION 0.247 0.214 False False IGHV5 NA NA None None None None None 9jkt S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/29/25 PLA-HCAR3-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Binghao, Z., Fang, Y. 3.05 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jkx S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/29/25 acifran-HCAR3-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Binghao, Z., Fang, Y. 3.18 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jky S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/29/25 acifran-HCAR2-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Binghao, Z., Fang, Y. 2.72 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k6y H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with H4 Fab (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, G., Li, L.J., Wu, Y., Gao, G.F. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9nz4 D C 0 A protein NA membrane protein MEMBRANE PROTEIN/IMMUNE SYSTEM/INHIBITOR 10/29/25 SARS-CoV M protein dimer in complex with FAb B Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Mann, M.K., Abeywickrema, P. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nz4 F E 0 B protein NA membrane protein MEMBRANE PROTEIN/IMMUNE SYSTEM/INHIBITOR 10/29/25 SARS-CoV M protein dimer in complex with FAb B Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Mann, M.K., Abeywickrema, P. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nz5 B C 0 A protein NA membrane protein MEMBRANE PROTEIN/IMMUNE SYSTEM/INHIBITOR 10/29/25 MERSmut-CoV M protein dimer in complex with FAb B Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Mann, M.K., Abeywickrema, P. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nz5 F E 0 D protein NA membrane protein MEMBRANE PROTEIN/IMMUNE SYSTEM/INHIBITOR 10/29/25 MERSmut-CoV M protein dimer in complex with FAb B Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Mann, M.K., Abeywickrema, P. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9sfx B A 0 C protein NA interleukin-17a CYTOKINE 10/29/25 Secukinumab Fv in complex with human IL-17A Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.-M., Lehmann, S. 2.6 X-RAY DIFFRACTION 0.213 0.177 False True IGHV3 IGKV3 Kappa None None None None None 9sfx H L 0 C protein NA interleukin-17a CYTOKINE 10/29/25 Secukinumab Fv in complex with human IL-17A Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.-M., Lehmann, S. 2.6 X-RAY DIFFRACTION 0.213 0.177 False True IGHV3 IGKV1 Kappa None None None None None 9sg0 H L 0 A protein NA interleukin-17a CYTOKINE 10/29/25 CJM112 Fv in complex with human IL-17A Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.-M., Lehmann, S. 2.65 X-RAY DIFFRACTION 0.256 0.195 False True IGHV3 IGKV1 Kappa None None None None None 9sg2 H L 0 A protein NA interleukin-17a CYTOKINE 10/29/25 Ixekizumab Fab in complex with human IL-17A Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Rondeau, J.-M., Lehmann, S. 2.92 X-RAY DIFFRACTION 0.246 0.192 False True IGHV1 IGKV2 Kappa None None None None None 9sgh A B 0 I protein NA interleukin-17a CYTOKINE 10/29/25 Bimekizumab Fab in complex with human interleukin-17A Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Rondeau, J.-M., Lehmann, S. 2.661 X-RAY DIFFRACTION 0.253 0.221 False True IGHV3 IGKV1 Kappa None None None None None 9sgh H L 0 J protein NA interleukin-17a CYTOKINE 10/29/25 Bimekizumab Fab in complex with human interleukin-17A Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Rondeau, J.-M., Lehmann, S. 2.661 X-RAY DIFFRACTION 0.253 0.221 False True IGHV3 IGKV1 Kappa None None None None None 9ubq C D 0 A protein NA middle s protein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 HBsAg in complex with H020 Fab Hepatitis B virus; Homo sapiens homo sapiens homo sapiens hepatitis b virus Chen, L., Tao, W., He, X. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9ubq E F 0 B protein NA middle s protein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 HBsAg in complex with H020 Fab Hepatitis B virus; Homo sapiens homo sapiens homo sapiens hepatitis b virus Chen, L., Tao, W., He, X. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9ucp C NA 0 A protein NA m1 muscarinic acetylcholine receptor, de novo designprotein MEMBRANE PROTEIN/IMMUNE SYSTEM 10/29/25 cryo-EM structure of M1 muscarinic acetylcholine receptor-alpha5 helix of G11 protein complex bound to iperoxo and nanobody Nb1B4 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Zhang, X., Gao, K., Liu, X. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uev B NA 0 A protein NA sftsv gn head VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the SFTSV Gn head protein in complex with Nb261 and Nb318 Severe fever with thrombocytopenia syndrome virus; Vicugna pacos vicugna pacos severe fever with thrombocytopenia syndromevirus Liang, S.J., Lou, Z.Y., Wu, X.L. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uev C NA 0 A protein NA sftsv gn head VIRAL PROTEIN/IMMUNE SYSTEM 10/29/25 Structure of the SFTSV Gn head protein in complex with Nb261 and Nb318 Severe fever with thrombocytopenia syndrome virus; Vicugna pacos vicugna pacos severe fever with thrombocytopenia syndromevirus Liang, S.J., Lou, Z.Y., Wu, X.L. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uk5 H L 0 A protein NA interleukin 31 CYTOKINE/IMMUNE SYSTEM 10/29/25 crystal structure of the complex of interleukin-31 and its antibody Canis lupus familiaris canis lupus familiaris canis lupus familiaris canis lupus familiaris Guo, T., Gao, F., Xiao, H. 1.9 X-RAY DIFFRACTION 0.239 0.201 False True IGHV5 IGKV6 Kappa None None None None None 9vp0 H L 0 A protein NA interleukin 31 CYTOKINE/IMMUNE SYSTEM 10/29/25 Structural insights into IL-31 signaling inhibition by a neutralization antibody Canis lupus familiaris canis lupus familiaris canis lupus familiaris canis lupus familiaris Guo, T., Gao, F., Xiao, H. 2.1 X-RAY DIFFRACTION 0.234 0.191 False True IGHV5 IGKV6 Kappa None None None None None 9bhh N M 0 G | A protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/22/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab IM-CKV063 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus | chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bhh P O 0 F | C protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/22/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab IM-CKV063 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus | chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bhh R Q 0 E | B protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/22/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab IM-CKV063 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus | chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bhh T S 0 H protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/22/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab IM-CKV063 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9jy0 B A 0 f protein NA unknown IMMUNE SYSTEM 10/22/25 Fab-CD3-gamma epsilon-TCR complex Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9jy1 P O 0 e protein NA unknown IMMUNE SYSTEM 10/22/25 delta epsilon/delta epsilon Fab-TCR tetramer Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9jy1 R Q 0 E protein NA t-cell surface glycoprotein cd3 epsilon chain IMMUNE SYSTEM 10/22/25 delta epsilon/delta epsilon Fab-TCR tetramer Homo sapiens homo sapiens homo sapiens homo sapiens Wang, L., Li, J., Li, Z. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9hh9 E D 0 A protein NA glycoprotein VIRAL PROTEIN 10/22/25 Cryo-EM structure of VSV-Indiana glycoprotein (MUDD-SUMMERS strain) in its pre-fusion conformation in complex with 8G5F11 Fab Mus sp.; Vesicular stomatitis virus mus sp. mus sp. vesicular stomatitis virus Albertini, A., Minoves, M.J., OuldAli, M., Gaudin, Y., Schoehn, G., Zarkadas, E. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 9hh9 G F 0 B protein NA glycoprotein VIRAL PROTEIN 10/22/25 Cryo-EM structure of VSV-Indiana glycoprotein (MUDD-SUMMERS strain) in its pre-fusion conformation in complex with 8G5F11 Fab Mus sp.; Vesicular stomatitis virus mus sp. mus sp. vesicular stomatitis virus Albertini, A., Minoves, M.J., OuldAli, M., Gaudin, Y., Schoehn, G., Zarkadas, E. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 9hh9 I H 0 C protein NA glycoprotein VIRAL PROTEIN 10/22/25 Cryo-EM structure of VSV-Indiana glycoprotein (MUDD-SUMMERS strain) in its pre-fusion conformation in complex with 8G5F11 Fab Mus sp.; Vesicular stomatitis virus mus sp. mus sp. vesicular stomatitis virus Albertini, A., Minoves, M.J., OuldAli, M., Gaudin, Y., Schoehn, G., Zarkadas, E. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 9jo7 J NA 0 A protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb4 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo7 C NA 0 B protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb4 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo7 E NA 0 D protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb4 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo7 G NA 0 F protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb4 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo7 I NA 0 H protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb4 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 O NA 0 S protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 A NA 0 B protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 C NA 0 D protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 E NA 0 F protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 G NA 0 H protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 I NA 0 J protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 K NA 0 L protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 M NA 0 N protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 P NA 0 Q protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jo9 R NA 0 T protein NA c-reactive protein IMMUNE SYSTEM 10/22/25 CRP-HCAb3 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, Y.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9l42 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/22/25 Cryo-EM structure of human histamine receptor H4R in complex with agonist histamine and Gi proteins Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Chen, A., Zhang, H. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9n8q H L 0 NA NA NA NA IMMUNE SYSTEM 10/22/25 Crystal structure of Trastuzumab Fab with P151A Homo sapiens homo sapiens homo sapiens Choi, W.S., Tilegenova, C., Are, M., Zwolak, A., Shaffer, P., Sharma, S. 2.6 X-RAY DIFFRACTION 0.278 0.213 False True IGHV3 IGKV1 Kappa None None None None None 9ub6 B NA 0 A protein NA glycoprotein n VIRAL PROTEIN 10/22/25 Crystal structure of SFTSV Gn head with nanobody VHH261 Homo sapiens; SFTS virus HB29 homo sapiens sfts virus hb29 Wu, Y., Chang, Z., Wu, X. 2.89 X-RAY DIFFRACTION 0.221 0.191 False True IGHV1 NA NA None None None None None 9n5i F E 0 D protein NA gametocyte surface protein p45/48 IMMUNE SYSTEM 10/15/25 Endogenous Pfs230D13-14 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., Heide, F., Bekkering, E., Ivanochko, D., Yoo, R., Julien, J.P. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9n5i H L 0 D protein NA gametocyte surface protein p45/48 IMMUNE SYSTEM 10/15/25 Endogenous Pfs230D13-14 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., Heide, F., Bekkering, E., Ivanochko, D., Yoo, R., Julien, J.P. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yy6 D F 0 A protein NA balf4 VIRAL PROTEIN/IMMUNE SYSTEM 10/15/25 Structure of a murine monoclonal antibody Fab5 targeting Epstein-Barr virus gB Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Fang, X.Y., Sun, C., Zeng, M.S., Liu, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8yy6 E H 0 B protein NA balf4 VIRAL PROTEIN/IMMUNE SYSTEM 10/15/25 Structure of a murine monoclonal antibody Fab5 targeting Epstein-Barr virus gB Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Fang, X.Y., Sun, C., Zeng, M.S., Liu, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8yy6 G I 0 C protein NA balf4 VIRAL PROTEIN/IMMUNE SYSTEM 10/15/25 Structure of a murine monoclonal antibody Fab5 targeting Epstein-Barr virus gB Homo sapiens; human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Fang, X.Y., Sun, C., Zeng, M.S., Liu, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9dvb H L 0 B protein NA soluble cytochrome b562 MEMBRANE PROTEIN 10/15/25 Thermus thermophilus MreC-MreD complex with an internal MreD BRIL fusion and an anti-BRIL Fab Escherichia coli; synthetic construct; Thermus thermophilus synthetic construct synthetic construct escherichia coli Gilman, M.S.A., Kruse, A.C. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dvb W X 0 N protein NA soluble cytochrome b562 MEMBRANE PROTEIN 10/15/25 Thermus thermophilus MreC-MreD complex with an internal MreD BRIL fusion and an anti-BRIL Fab Escherichia coli; synthetic construct; Thermus thermophilus synthetic construct synthetic construct escherichia coli Gilman, M.S.A., Kruse, A.C. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dvc H L 0 B protein NA soluble cytochrome b562 MEMBRANE PROTEIN 10/15/25 Thermus thermophilus MreC-MreD complex with a C-terminal MreD BRIL fusion and an anti-BRIL Fab Escherichia coli; synthetic construct; Thermus thermophilus synthetic construct synthetic construct escherichia coli Gilman, M.S.A., Kruse, A.C. 7.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dvd H L 0 A protein NA glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/15/25 Cryo EM structure of Hendra G ectodomain in complex with Ephrin-B2 and Fab HENV-270 Henipavirus hendraense; Homo sapiens homo sapiens homo sapiens henipavirus hendraense Binshtein, E., Crowe, J.E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV7 IGLV3 Lambda None None None None None 9i1q J E 0 NA NA NA NA ANTITUMOR PROTEIN 10/15/25 HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody Homo sapiens homo sapiens homo sapiens Bulfaro, G., Savino, C., Costanzo, A., Fata, F., Vallone, B., Montemiglio, L.C. 2.8 X-RAY DIFFRACTION 0.263 0.209 False True IGHV2 IGKV2 Kappa None None None None None 9i1q I F 0 NA NA NA NA ANTITUMOR PROTEIN 10/15/25 HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody Homo sapiens homo sapiens homo sapiens Bulfaro, G., Savino, C., Costanzo, A., Fata, F., Vallone, B., Montemiglio, L.C. 2.8 X-RAY DIFFRACTION 0.263 0.209 False True IGHV2 IGKV2 Kappa None None None None None 9i1q K G 0 D protein NA receptor tyrosine-protein kinase erbb-3 ANTITUMOR PROTEIN 10/15/25 HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody Homo sapiens homo sapiens homo sapiens homo sapiens Bulfaro, G., Savino, C., Costanzo, A., Fata, F., Vallone, B., Montemiglio, L.C. 2.8 X-RAY DIFFRACTION 0.263 0.209 False True IGHV2 IGKV2 Kappa None None None None None 9i1q L H 0 NA NA NA NA ANTITUMOR PROTEIN 10/15/25 HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody Homo sapiens homo sapiens homo sapiens Bulfaro, G., Savino, C., Costanzo, A., Fata, F., Vallone, B., Montemiglio, L.C. 2.8 X-RAY DIFFRACTION 0.263 0.209 False True IGHV2 IGKV2 Kappa None None None None None 9k3t H L 0 A protein NA transmembrane protease serine 2 MEMBRANE PROTEIN 10/15/25 Cryo-EM structure of TMPRSS2 in complex with Fab fragments of 752 mAb and 2228 mAb Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Katsura, K., Hisano, T., Matsumoto, T., Shirouzu, M. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV19 Kappa None None None None None 9k3t h l 0 A protein NA transmembrane protease serine 2 MEMBRANE PROTEIN 10/15/25 Cryo-EM structure of TMPRSS2 in complex with Fab fragments of 752 mAb and 2228 mAb Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Katsura, K., Hisano, T., Matsumoto, T., Shirouzu, M. 3.15 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 9kur H L 0 B protein NA nucleoprotein VIRAL PROTEIN 10/15/25 Crystal structure of mAb nCoV400Fab with SARS-CoV-2 N-CTD Complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xue, S.J., Chen, S.D. 2.06 X-RAY DIFFRACTION 0.249 0.199 False True IGHV3 IGLV3 Lambda None None None None None 9kur G D 0 A protein NA nucleoprotein VIRAL PROTEIN 10/15/25 Crystal structure of mAb nCoV400Fab with SARS-CoV-2 N-CTD Complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xue, S.J., Chen, S.D. 2.06 X-RAY DIFFRACTION 0.249 0.199 False True IGHV3 IGLV3 Lambda None None None None None 9lra H L 0 K protein NA killer cell immunoglobulin-like receptor 2dl2 IMMUNE SYSTEM 10/15/25 Killer immunoglobulin receptor KIR2DL2 in complex with Pan2D Fab Homo sapiens homo sapiens homo sapiens homo sapiens Nishikawa, Y. 2.6 X-RAY DIFFRACTION 0.252 0.220 False True IGHV1 IGKV4 Kappa None None None None None 9lrf H L 0 K protein NA killer cell immunoglobulin-like receptor 2dl2 IMMUNE SYSTEM 10/15/25 Killer immunoglobulin receptor KIR2DL2 in complex with KIR2DL2_KIR2DL2/3 agonist 61-Fab Homo sapiens homo sapiens homo sapiens homo sapiens Nishikawa, Y. 2.5 X-RAY DIFFRACTION 0.274 0.234 False True IGHV1 IGKV1 Kappa None None None None None 9n5h B C 0 A protein NA gametocyte surface protein p230 IMMUNE SYSTEM 10/15/25 Endogenous Pfs230D1-6 in complex with RUPA-97, LMIV230-01, and 2A2 Fab domains Homo sapiens; Mus musculus; Plasmodium falciparum 3D7 mus musculus mus musculus plasmodium falciparum 3d7 Heide, F., Yoo, R., Ivanochko, D., Hailemariam, S., Bekkering, E., Julien, J.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9n5h D E 0 A protein NA gametocyte surface protein p230 IMMUNE SYSTEM 10/15/25 Endogenous Pfs230D1-6 in complex with RUPA-97, LMIV230-01, and 2A2 Fab domains Homo sapiens; Mus musculus; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Heide, F., Yoo, R., Ivanochko, D., Hailemariam, S., Bekkering, E., Julien, J.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9n5h H L 0 A protein NA gametocyte surface protein p230 IMMUNE SYSTEM 10/15/25 Endogenous Pfs230D1-6 in complex with RUPA-97, LMIV230-01, and 2A2 Fab domains Homo sapiens; Mus musculus; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Heide, F., Yoo, R., Ivanochko, D., Hailemariam, S., Bekkering, E., Julien, J.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9n5o H L 0 B protein NA gametocyte surface protein p230 IMMUNE SYSTEM 10/15/25 Endogenous Pfs230D7-8 in complex with 18F25 Mus musculus; Plasmodium falciparum 3D7 mus musculus mus musculus plasmodium falciparum 3d7 Jackman, J.J., Yoo, R., Ivanochko, D., Hailemariam, S., Bekkering, E., Julien, J.P. 4.32 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9n6u H L 0 NA NA NA NA IMMUNE SYSTEM 10/15/25 Crystal structure of 18F25 malarial antibody Mus musculus mus musculus mus musculus Yoo, R., Julien, J.P. 1.6 X-RAY DIFFRACTION 0.214 0.188 False True IGHV1 IGKV6 Kappa None None None None None 9n7k A B 0 NA NA NA NA IMMUNE SYSTEM 10/15/25 Crystal structure of human anti-Pfs48/45 transmission-blocking antibody RUPA-71 Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Liu, X., Julien, J.P. 2.28 X-RAY DIFFRACTION 0.241 0.191 False True IGHV3 IGKV3 Kappa None None None None None 9n7k H L 0 NA NA NA NA IMMUNE SYSTEM 10/15/25 Crystal structure of human anti-Pfs48/45 transmission-blocking antibody RUPA-71 Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Liu, X., Julien, J.P. 2.28 X-RAY DIFFRACTION 0.241 0.191 False True IGHV3 IGKV3 Kappa None None None None None 9n89 H L 0 NA NA NA NA IMMUNE SYSTEM 10/15/25 Crystal structure of 2A2 malarial antibody Mus musculus mus musculus mus musculus Yoo, R., Julien, J.P. 1.2 X-RAY DIFFRACTION 0.194 0.186 False True IGHV1 IGKV6 Kappa None None None None None 9bbn M N 0 G | V | A protein | protein | protein NA | NA | NA e2 glycoprotein | e3 glycoprotein | e1 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab C9 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus | chikungunya virus | chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bbn O P 0 F | C | W protein | protein | protein NA | NA | NA e2 glycoprotein | e1 glycoprotein | e3 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab C9 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus | chikungunya virus | chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bbn Q R 0 E | B | X protein | protein | protein NA | NA | NA e2 glycoprotein | e1 glycoprotein | e3 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab C9 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus | chikungunya virus | chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bbn S T 0 H | U protein | protein NA | NA e2 glycoprotein | e3 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Cryo-EM structure of Chikungunya virus asymmetric unit with Fab C9 Chikungunya virus; Mus musculus mus musculus mus musculus chikungunya virus | chikungunya virus Su, G.C., Galaz-Montoya, J.G., Pintilie, G., Jin, J., Chiu, W. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9n4e K M 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Structure of AG2-G02 Fab in complex with influenza H3N8 A/Mallard/Alberta/362/2017 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gopal, A.B., Wu, N.C., Lv, H., Pholcharee, T. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9n4e O R 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Structure of AG2-G02 Fab in complex with influenza H3N8 A/Mallard/Alberta/362/2017 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gopal, A.B., Wu, N.C., Lv, H., Pholcharee, T. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9n4e Q P 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Structure of AG2-G02 Fab in complex with influenza H3N8 A/Mallard/Alberta/362/2017 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gopal, A.B., Wu, N.C., Lv, H., Pholcharee, T. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9n4f H L 0 B | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Structure of 240-14-IgA_2F02 Fab in complex with influenza H3N8 A/Mallard/Alberta/362/2017 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gopal, A.B., Wu, N.C., Lv, H., Pholcharee, T. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9n4f M N 0 D | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Structure of 240-14-IgA_2F02 Fab in complex with influenza H3N8 A/Mallard/Alberta/362/2017 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gopal, A.B., Wu, N.C., Lv, H., Pholcharee, T. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9n4f O P 0 F | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Structure of 240-14-IgA_2F02 Fab in complex with influenza H3N8 A/Mallard/Alberta/362/2017 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gopal, A.B., Wu, N.C., Lv, H., Pholcharee, T. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9c6y A B 0 E protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Crystal structure of SARS-CoV-2 XBB.1.5 RBD bound to COV2-3906 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Buchman, C.D., Crowe, J.E. 2.68 X-RAY DIFFRACTION 0.242 0.207 False True IGHV4 IGLV6 Lambda None None None None None 9c6y C D 0 F protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Crystal structure of SARS-CoV-2 XBB.1.5 RBD bound to COV2-3906 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Buchman, C.D., Crowe, J.E. 2.68 X-RAY DIFFRACTION 0.242 0.207 False True IGHV4 IGLV6 Lambda None None None None None 9c7s H L 0 C protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 10/08/25 Cryo EM structure of SARS-COV-2 (BQ 1.1) RBD in complex with Fab COV2-3891 (local refine) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Binshtein, E., Crowe, J.E. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9gvl H h 0 A protein NA interferon alpha-2 IMMUNE SYSTEM 10/08/25 type-I interferons autoantibody pmab15 in complex with Interferon alpha-2 Homo sapiens homo sapiens homo sapiens Duquerroy, S., Rey, F., Mahevas, M., Chappert, P., Ahouzi, O. 2.006 X-RAY DIFFRACTION 0.270 0.214 True True unknown unknown unknown None None None None None 9gvl I i 0 B protein NA interferon alpha-2 IMMUNE SYSTEM 10/08/25 type-I interferons autoantibody pmab15 in complex with Interferon alpha-2 Homo sapiens homo sapiens homo sapiens Duquerroy, S., Rey, F., Mahevas, M., Chappert, P., Ahouzi, O. 2.006 X-RAY DIFFRACTION 0.270 0.214 True True unknown unknown unknown None None None None None 9gvo A a 0 B protein NA interferon alpha-2 IMMUNE SYSTEM 10/08/25 type-I interferons autoantibodies pmab15 and pmab14 in complex with Interferon alpha-2 Homo sapiens homo sapiens homo sapiens Duquerroy, S., Rey, F., Ahouzi, O., Mahevas, M., Chappert, P. 1.81 X-RAY DIFFRACTION 0.215 0.193 True True unknown unknown unknown None None None None None 9gvo H h 0 B protein NA interferon alpha-2 IMMUNE SYSTEM 10/08/25 type-I interferons autoantibodies pmab15 and pmab14 in complex with Interferon alpha-2 Homo sapiens homo sapiens homo sapiens Duquerroy, S., Rey, F., Ahouzi, O., Mahevas, M., Chappert, P. 1.81 X-RAY DIFFRACTION 0.215 0.193 True True unknown unknown unknown None None None None None 9gw5 H h 0 A protein NA interferon alpha-2 IMMUNE SYSTEM 10/08/25 type-I interferon autoantibodies pmab3, pmab19 and pmab14 in complex with Interferon alpha-2 Homo sapiens homo sapiens homo sapiens Duquerroy, S., Rey, F., Mahevas, M., Chappert, P., Ahouzi, O. 4 X-RAY DIFFRACTION 0.324 0.294 True True unknown unknown unknown None None None None None 9gw5 U u 0 A protein NA interferon alpha-2 IMMUNE SYSTEM 10/08/25 type-I interferon autoantibodies pmab3, pmab19 and pmab14 in complex with Interferon alpha-2 Homo sapiens homo sapiens homo sapiens Duquerroy, S., Rey, F., Mahevas, M., Chappert, P., Ahouzi, O. 4 X-RAY DIFFRACTION 0.324 0.294 True True unknown unknown unknown None None None None None 9gw5 V v 0 A protein NA interferon alpha-2 IMMUNE SYSTEM 10/08/25 type-I interferon autoantibodies pmab3, pmab19 and pmab14 in complex with Interferon alpha-2 Homo sapiens homo sapiens homo sapiens Duquerroy, S., Rey, F., Mahevas, M., Chappert, P., Ahouzi, O. 4 X-RAY DIFFRACTION 0.324 0.294 True True unknown unknown unknown None None None None None 9luk H L 0 NA NA NA NA IMMUNE SYSTEM 10/08/25 Crystal structure of Switchbody based on anti-osteocalcin antibody KTM219 Fab Mus musculus mus musculus mus musculus Yazaki, S., Yasuda, T., Kitaguchi, T., Ueda, H., Arai, R. 1.95 X-RAY DIFFRACTION 0.238 0.202 False True IGHV1 IGKV1 Kappa None None None None None 5omm C NA 0 A | B protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN 10/04/17 GII.10 Vietnam 026 protruding domain in complex with Nanobody Nano-14 Norovirus GII.10; Vicugna pacos vicugna pacos norovirus gii.10 | norovirus gii.10 Koromyslova, A.D., Hansman, G.S. 1.7 X-RAY DIFFRACTION 0.193 0.166 False True IGHV1 NA NA None None None None None 9mba S s 0 C | D protein | protein NA | NA beta-arrestin-1 | metabotropic glutamate receptor 8 MEMBRANE PROTEIN 10/01/25 Cryo-EM structure of complex of transducer-bound GPCR Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, J., Zhao, C., Sun, H., Shao, Z.H. 3.14 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mba T t 0 B | R protein | protein NA | NA beta-arrestin-1 | metabotropic glutamate receptor 8 MEMBRANE PROTEIN 10/01/25 Cryo-EM structure of complex of transducer-bound GPCR Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, J., Zhao, C., Sun, H., Shao, Z.H. 3.14 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9pix H L 0 A | P protein | peptide NA | NA mhc class i antigen | c18v peptide VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Mur14 Fab with HBV c18V pMHC Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | hepatitis b virus Mortenson, D.E. 2.35 X-RAY DIFFRACTION 0.236 0.185 False True IGHV1 IGKV3 Kappa None None None None None 9pkc H L 0 A | P protein | peptide NA | NA mhc class i antigen | c18v peptide VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Mur35 Fab with HBV c18V pMHC Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | hepatitis b virus Mortenson, D.E. 2.5 X-RAY DIFFRACTION 0.303 0.258 False True IGHV1 IGKV3 Kappa None None None None None 9pkf H L 0 A | P protein | peptide NA | NA mhc class i antigen | c18i peptide VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Mur35 Fab with HBV c18I pMHC Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | hepatitis b virus Mortenson, D.E. 2.6 X-RAY DIFFRACTION 0.303 0.247 False True IGHV1 IGKV3 Kappa None None None None None 9pkv H L 0 A | P protein | peptide NA | NA mhc class i antigen | prame peptide PEPTIDE BINDING PROTEIN/IMMUNE SYSTEM 10/01/25 HU-38 Fab with PRAME pMHC Homo sapiens; Lama glama; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Mortenson, D.E., Yu, X. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pkv K NA 0 NA NA NA NA PEPTIDE BINDING PROTEIN/IMMUNE SYSTEM 10/01/25 HU-38 Fab with PRAME pMHC Homo sapiens; Lama glama; Mus musculus; SYNTHETIC CONSTRUCT lama glama Mortenson, D.E., Yu, X. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8yub A B 0 F protein NA spike protein s2' IMMUNE SYSTEM 10/01/25 Crystal structure of SARS-CoV-2 ConSp RBD in complex with neutralizing antibody CC25.4 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kang, J.M., Yuan, M., Han, B.W., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.255 0.205 False True IGHV1 IGLV1 Lambda None None None None None 8yub D E 0 C protein NA spike protein s2' IMMUNE SYSTEM 10/01/25 Crystal structure of SARS-CoV-2 ConSp RBD in complex with neutralizing antibody CC25.4 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kang, J.M., Yuan, M., Han, B.W., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.255 0.205 False True IGHV1 IGLV1 Lambda None None None None None 8yuc A B 0 G protein NA spike protein s2' IMMUNE SYSTEM 10/01/25 Crystal structure of SARS-CoV-2 ConSp RBD in complex with antibodies PDI222 Fab and COVA1-16 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kang, J.M., Yuan, M., Han, B.W., Wilson, I.A. 4.51 X-RAY DIFFRACTION 0.308 0.275 False True IGHV1 IGKV3 Kappa None None None None None 8yuc H L 0 G protein NA spike protein s2' IMMUNE SYSTEM 10/01/25 Crystal structure of SARS-CoV-2 ConSp RBD in complex with antibodies PDI222 Fab and COVA1-16 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kang, J.M., Yuan, M., Han, B.W., Wilson, I.A. 4.51 X-RAY DIFFRACTION 0.308 0.275 False True IGHV1 IGKV1 Kappa None None None None None 9ds3 A I 0 NA NA NA NA IMMUNE SYSTEM 10/01/25 Crystal structure of Apo-241_2F04 Fab Homo sapiens homo sapiens homo sapiens Lin, T.H., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.234 0.207 False True IGHV3 IGKV3 Kappa None None None None None 9ds3 B C 0 NA NA NA NA IMMUNE SYSTEM 10/01/25 Crystal structure of Apo-241_2F04 Fab Homo sapiens homo sapiens homo sapiens Lin, T.H., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.234 0.207 False True IGHV3 IGKV3 Kappa None None None None None 9dsr A B 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM 10/01/25 Crystal structure of Fab MS-1805 in complex with NPNA3 peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 2.25 X-RAY DIFFRACTION 0.239 0.188 False True IGHV3 IGKV1 Kappa None None None None None 9dss C B 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 10/01/25 Crystal structure of Fab 7088 in complex with NPNA3 peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 2 X-RAY DIFFRACTION 0.263 0.229 False True IGHV3 IGKV1 Kappa None None None None None 9dst C D 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 10/01/25 Crystal structure of Fab MS-1805 in complex with N-terminal junction peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 1.74 X-RAY DIFFRACTION 0.228 0.197 False True IGHV3 IGKV1 Kappa None None None None None 9dsu C B 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 10/01/25 Crystal structure of Fab 7088 in complex with N-terminal junction peptide from circumsporozoite protein Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Jain, M., Wilson, I.A. 3.14 X-RAY DIFFRACTION 0.275 0.233 False True IGHV3 IGKV1 Kappa None None None None None 9gv3 E NA 0 A protein NA fructose-bisphosphate aldolase LYASE 10/01/25 Crystal structure of the complex between Nb474 mutant R53A,D125A and Trypanosoma congolense fructose-1,6-bisphosphate aldolase Trypanosoma congolense IL3000; Vicugna pacos vicugna pacos trypanosoma congolense il3000 McNae, I.W., Dornan, J., Walkinshaw, M.D. 1.751 X-RAY DIFFRACTION 0.188 0.160 False True IGHV1 NA NA None None None None None 9gv3 F NA 0 B protein NA fructose-bisphosphate aldolase LYASE 10/01/25 Crystal structure of the complex between Nb474 mutant R53A,D125A and Trypanosoma congolense fructose-1,6-bisphosphate aldolase Trypanosoma congolense IL3000; Vicugna pacos vicugna pacos trypanosoma congolense il3000 McNae, I.W., Dornan, J., Walkinshaw, M.D. 1.751 X-RAY DIFFRACTION 0.188 0.160 False True IGHV1 NA NA None None None None None 9gv3 G NA 0 C protein NA fructose-bisphosphate aldolase LYASE 10/01/25 Crystal structure of the complex between Nb474 mutant R53A,D125A and Trypanosoma congolense fructose-1,6-bisphosphate aldolase Trypanosoma congolense IL3000; Vicugna pacos vicugna pacos trypanosoma congolense il3000 McNae, I.W., Dornan, J., Walkinshaw, M.D. 1.751 X-RAY DIFFRACTION 0.188 0.160 False True IGHV1 NA NA None None None None None 9gv3 H NA 0 D protein NA fructose-bisphosphate aldolase LYASE 10/01/25 Crystal structure of the complex between Nb474 mutant R53A,D125A and Trypanosoma congolense fructose-1,6-bisphosphate aldolase Trypanosoma congolense IL3000; Vicugna pacos vicugna pacos trypanosoma congolense il3000 McNae, I.W., Dornan, J., Walkinshaw, M.D. 1.751 X-RAY DIFFRACTION 0.188 0.160 False True IGHV1 NA NA None None None None None 9jpv A B 0 NA NA NA NA IMMUNE SYSTEM 10/01/25 A Fab Fragment of IgG Rattus norvegicus rattus norvegicus rattus norvegicus Makabe, K. 1.94 X-RAY DIFFRACTION 0.246 0.222 False True IGHV4 IGKV3 Kappa None None None None None 9jpv C D 0 NA NA NA NA IMMUNE SYSTEM 10/01/25 A Fab Fragment of IgG Rattus norvegicus rattus norvegicus rattus norvegicus Makabe, K. 1.94 X-RAY DIFFRACTION 0.246 0.222 False True IGHV4 IGKV3 Kappa None None None None None 9jrs A NA 0 NA NA NA NA ANTITUMOR PROTEIN 10/01/25 Crystal structure of BH1 Vicugna pacos vicugna pacos Wang, H., Guan, X. 1.46 X-RAY DIFFRACTION 0.252 0.213 False True IGHV1 NA NA None None None None None 9js6 H L 0 B protein NA envelope protein e VIRUS/IMMUNE SYSTEM 10/01/25 cryoEM of antibody complexed with immature Zika virus Homo sapiens; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Shu, B., Lok, S. 7.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9js7 I L 0 B protein NA genome polyprotein VIRUS/IMMUNE SYSTEM 10/01/25 cryoEM of antibody complexed with mature Zika virus Homo sapiens; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Shu, B., Lok, S. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9js7 J M 0 C protein NA genome polyprotein VIRUS/IMMUNE SYSTEM 10/01/25 cryoEM of antibody complexed with mature Zika virus Homo sapiens; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Shu, B., Lok, S. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9leo A B 0 H protein NA attachment glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 LayV-G Head in complex of LayG-1069 and LayG-1133 Langya virus; Mus musculus mus musculus mus musculus langya virus Yan, R.H., Wu, S.Y. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 9leo C D 0 H protein NA attachment glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 LayV-G Head in complex of LayG-1069 and LayG-1133 Langya virus; Mus musculus mus musculus mus musculus langya virus Yan, R.H., Wu, S.Y. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV12 Kappa None None None None None 9lf8 F E 0 R protein NA entry-fusion complex associated protein opg095 VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of MPXV M1R and mMM1-16 Fab complex Monkeypox virus; Mus musculus mus musculus mus musculus monkeypox virus Zhang, Y., Zhao, R.C., Wu, L.L., Wang, Q.H. 2.7 X-RAY DIFFRACTION 0.274 0.202 False True IGHV1 IGKV12 Kappa None None None None None 9lf8 D C 0 S protein NA entry-fusion complex associated protein opg095 VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of MPXV M1R and mMM1-16 Fab complex Monkeypox virus; Mus musculus mus musculus mus musculus monkeypox virus Zhang, Y., Zhao, R.C., Wu, L.L., Wang, Q.H. 2.7 X-RAY DIFFRACTION 0.274 0.202 False True IGHV1 IGKV12 Kappa None None None None None 9lf8 H L 0 Q protein NA entry-fusion complex associated protein opg095 VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of MPXV M1R and mMM1-16 Fab complex Monkeypox virus; Mus musculus mus musculus mus musculus monkeypox virus Zhang, Y., Zhao, R.C., Wu, L.L., Wang, Q.H. 2.7 X-RAY DIFFRACTION 0.274 0.202 False True IGHV1 IGKV12 Kappa None None None None None 9lf8 O J 0 T protein NA entry-fusion complex associated protein opg095 VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of MPXV M1R and mMM1-16 Fab complex Monkeypox virus; Mus musculus mus musculus mus musculus monkeypox virus Zhang, Y., Zhao, R.C., Wu, L.L., Wang, Q.H. 2.7 X-RAY DIFFRACTION 0.274 0.202 False True IGHV1 IGKV12 Kappa None None None None None 9nn9 B NA 0 A protein NA ubiquitin-like protein isg15 IMMUNE SYSTEM 10/01/25 ISG15 complexed with nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Dabhade, P., Schwartz, T.U. 2.59 X-RAY DIFFRACTION 0.244 0.188 False True IGHV1 NA NA None None None None None 9nn9 D NA 0 C protein NA ubiquitin-like protein isg15 IMMUNE SYSTEM 10/01/25 ISG15 complexed with nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Dabhade, P., Schwartz, T.U. 2.59 X-RAY DIFFRACTION 0.244 0.188 False True IGHV1 NA NA None None None None None 9nn9 F NA 0 E protein NA ubiquitin-like protein isg15 IMMUNE SYSTEM 10/01/25 ISG15 complexed with nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Dabhade, P., Schwartz, T.U. 2.59 X-RAY DIFFRACTION 0.244 0.188 False True IGHV1 NA NA None None None None None 9nwu C c 0 NA NA NA NA SIGNALING PROTEIN 10/01/25 Crystal structure of a high affinity VL-VH tetrabody for the erythropoietin receptor Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Yang, N., Blazer, L.L., Adams, J.J., Sidhu, S.S. 1.96 X-RAY DIFFRACTION 0.215 0.167 True True unknown unknown unknown None None None None None 9nwu D d 0 NA NA NA NA SIGNALING PROTEIN 10/01/25 Crystal structure of a high affinity VL-VH tetrabody for the erythropoietin receptor Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Yang, N., Blazer, L.L., Adams, J.J., Sidhu, S.S. 1.96 X-RAY DIFFRACTION 0.215 0.167 True True unknown unknown unknown None None None None None 9nwu A a 0 NA NA NA NA SIGNALING PROTEIN 10/01/25 Crystal structure of a high affinity VL-VH tetrabody for the erythropoietin receptor Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Yang, N., Blazer, L.L., Adams, J.J., Sidhu, S.S. 1.96 X-RAY DIFFRACTION 0.215 0.167 True True unknown unknown unknown None None None None None 9nwu B b 0 NA NA NA NA SIGNALING PROTEIN 10/01/25 Crystal structure of a high affinity VL-VH tetrabody for the erythropoietin receptor Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Yang, N., Blazer, L.L., Adams, J.J., Sidhu, S.S. 1.96 X-RAY DIFFRACTION 0.215 0.167 True True unknown unknown unknown None None None None None 9osr J N 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of Fab HB420 in complex with influenza H3N2 A/Moscow/10/1999 neuraminidase Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Lv, H., Wu, N.C. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9osr H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of Fab HB420 in complex with influenza H3N2 A/Moscow/10/1999 neuraminidase Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Lv, H., Wu, N.C. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9osr K R 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of Fab HB420 in complex with influenza H3N2 A/Moscow/10/1999 neuraminidase Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Lv, H., Wu, N.C. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9osr I M 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of Fab HB420 in complex with influenza H3N2 A/Moscow/10/1999 neuraminidase Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Lv, H., Wu, N.C. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9vhz A B 0 Q protein NA entry-fusion complex associated protein opg095 VIRAL PROTEIN/IMMUNE SYSTEM 10/01/25 Structure of MPXV M1R and hmMM1-40 Fab complex Monkeypox virus; Mus musculus mus musculus mus musculus monkeypox virus Zhao, R.C., Zhang, Y., Wu, L.L., Wang, Q.H. 2.8 X-RAY DIFFRACTION 0.296 0.208 False True IGHV1 IGKV2 Kappa None None None None None 9mtf H L 0 B | A protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 14-1 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtf I J 0 D | C protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 14-1 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtf M N 0 F | E protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 14-1 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mth H L 0 B | A protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 14-8 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mth I J 0 D | C protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 14-8 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mth M N 0 F | E protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 14-8 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtj H L 0 B | A protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 15-5 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.65 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9mtj I J 0 F | E protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 15-5 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.65 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9mtj M N 0 D | C protein | protein NA | NA hemagglutinin (ha2 polypeptide) from influenza h1n1a/solomon island/3/2006 | hemagglutinin (ha1 polypeptide) from influenza h1n1a/solomon island/3/2006 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 15-5 in complex with influenza H1N1 A/Solomon Island/3/2006 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.65 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9mtk H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G17 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtk I J 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G17 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtk M N 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G17 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtl H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G23 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.41 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9mtl I J 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G23 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.41 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9mtl M N 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G23 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.41 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9mtm H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G28 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtm I J 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G28 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9mtm M N 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Structure of porcine Fab 24-1G28 in complex with influenza H1N1 A/Hawaii/70/2019 hemagglutinin Influenza A virus; Sus scrofa sus scrofa sus scrofa influenza a virus | influenza a virus Lv, H., Pholcharee, T., Wu, N.C. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV8 Lambda None None None None None 9cds B A 0 C protein NA outer surface protein a IMMUNE SYSTEM 09/24/25 Crystal structure of OspA ST1 from B. burgdorferi bound to monoclonal antibody LA-2 Borreliella burgdorferi B31; Mus musculus mus musculus mus musculus borreliella burgdorferi b31 Laciak, A.R., Lai, Y.-T., Dhingra, Y. 1.85 X-RAY DIFFRACTION 0.233 0.202 False True IGHV9 IGKV19 Kappa None None None None None 9cds E D 0 F protein NA outer surface protein a IMMUNE SYSTEM 09/24/25 Crystal structure of OspA ST1 from B. burgdorferi bound to monoclonal antibody LA-2 Borreliella burgdorferi B31; Mus musculus mus musculus mus musculus borreliella burgdorferi b31 Laciak, A.R., Lai, Y.-T., Dhingra, Y. 1.85 X-RAY DIFFRACTION 0.233 0.202 False True IGHV9 IGKV19 Kappa None None None None None 9gst H L 0 B | A protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN 09/24/25 LN02-ML85 Fab in complex with crosslinked DS-SOSIP HIV-1 Env trimer Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pedenko, B., Effantin, G., Weissenhorn, W. 3.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9jec D NA 0 A protein NA tumor necrosis factor CYTOKINE 09/24/25 Cryo-EM structure of canine TNF-alpha complexed with nanobody TNF30K Canis lupus familiaris; Lama glama lama glama canis lupus familiaris Weng, J., Li, Z., Xu, J., Wei, Z. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jec E NA 0 B protein NA tumor necrosis factor CYTOKINE 09/24/25 Cryo-EM structure of canine TNF-alpha complexed with nanobody TNF30K Canis lupus familiaris; Lama glama lama glama canis lupus familiaris Weng, J., Li, Z., Xu, J., Wei, Z. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jec F NA 0 C protein NA tumor necrosis factor CYTOKINE 09/24/25 Cryo-EM structure of canine TNF-alpha complexed with nanobody TNF30K Canis lupus familiaris; Lama glama lama glama canis lupus familiaris Weng, J., Li, Z., Xu, J., Wei, Z. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jeq S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/24/25 Cryo-EM structure of Histamine-bound Histamine receptor 3 H3R G protein complex Bos taurus; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Jin, S.S., Zhang, H., Jiang, Y. 3.05 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jmb H L 0 A protein NA glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Cryo-EM structure of HSV-2 gB and FAB 16F9 complex Human herpesvirus 2; Mus musculus mus musculus mus musculus human herpesvirus 2 Li, Y., Zheng, Q., Li, S. 2.18 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9jme H L 0 A protein NA virion glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Cryo-EM structure of BV gB and FAB 16F9 complex Cercopithecine herpesvirus 1; Mus musculus mus musculus mus musculus cercopithecine herpesvirus 1 Li, Y., Zheng, Q., Li, S. 2.18 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9jmr H L 0 A protein NA glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Cryo-EM structure of PRV gB and FAB 16f9 complex Mus musculus; Suid alphaherpesvirus 1 mus musculus mus musculus suid alphaherpesvirus 1 Li, Y., Zheng, Q., Li, S. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9jms H L 0 A protein NA glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/24/25 Cryo-EM structure of VZV gB and FAB 16F9 complex Human herpesvirus 3; Mus musculus mus musculus mus musculus human herpesvirus 3 Li, Y., Zheng, Q., Li, S. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9mqr D E 0 A protein NA adhesion g protein-coupled receptor e5 IMMUNE SYSTEM 09/24/25 A8 Fab in complex with CD97 Homo sapiens homo sapiens homo sapiens homo sapiens Hattori, T., Bang, I., Fang, M., Koide, S. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9p97 H L 0 A protein NA integrin alpha-e CELL ADHESION 09/24/25 CryoEM structure of the closed integrin alphaEbeta7 bound to fab LF61 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hollis, J.A., Campbell, M.G. 2.92 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9p98 H L 0 A protein NA integrin alpha-e CELL ADHESION 09/24/25 CryoEM structure of the open integrin alphaEbeta7 bound to fab LF61 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hollis, J.A., Campbell, M.G. 2.93 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9s8w H L 0 A protein NA heparanase CARBOHYDRATE 09/24/25 Human heparanase in complex with neutralizing antibody A54 Fab fragment Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Wu, L. 3.49 X-RAY DIFFRACTION 0.323 0.220 False True IGHV1 IGKV3 Kappa None None None None None 8zye B b 0 A protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 MEMBRANE PROTEIN 09/17/25 Crystal structure of CD38 in complex with RP02 antibody Homo sapiens homo sapiens homo sapiens Lei, Y. 2.72 X-RAY DIFFRACTION 0.271 0.214 True True unknown unknown unknown None None None None None 9bsb E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/17/25 Global reconstruction of DRD2 bound to LSD in complex with a mini-GoA and scFv16 obtained by cryo-electron microscopy (cryoEM) Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Kim, K., Gumpper, R.H., Fay, J.F., Roth, B.L. 2.32 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ccg B C 0 A protein NA potra domain-containing protein MEMBRANE PROTEIN 09/17/25 Fusobacterium nucleatum BamA-Fab 9 complex Fusobacterium nucleatum; synthetic construct synthetic construct synthetic construct fusobacterium nucleatum Overly Cottom, C., Noinaj, N. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ccg F E 0 D protein NA potra domain-containing protein MEMBRANE PROTEIN 09/17/25 Fusobacterium nucleatum BamA-Fab 9 complex Fusobacterium nucleatum; synthetic construct synthetic construct synthetic construct fusobacterium nucleatum Overly Cottom, C., Noinaj, N. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9hco H L 0 A protein NA sodium-dependent serotonin transporter MEMBRANE PROTEIN 09/17/25 Outward-open structure of human serotonin transporter bound to vilazodone Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kalenderoglou, I.E., Tillmann, P., Loland, C.J. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9r19 D NA 0 A protein NA processed angiotensin-converting enzyme 2 HYDROLASE 09/17/25 Crystal structure of human ACE2 in complex with VHH B07 and VHH B10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Blachier, S., Vaney, M.C., Fernandez, I., Arbabian, A., Rey, F.A.R., Haouz, A., Brelot, A. 2.69 X-RAY DIFFRACTION 0.255 0.220 False True IGHV1 NA NA None None None None None 9r19 E NA 0 B protein NA processed angiotensin-converting enzyme 2 HYDROLASE 09/17/25 Crystal structure of human ACE2 in complex with VHH B07 and VHH B10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Blachier, S., Vaney, M.C., Fernandez, I., Arbabian, A., Rey, F.A.R., Haouz, A., Brelot, A. 2.69 X-RAY DIFFRACTION 0.255 0.220 False True IGHV1 NA NA None None None None None 9r19 F NA 0 C protein NA processed angiotensin-converting enzyme 2 HYDROLASE 09/17/25 Crystal structure of human ACE2 in complex with VHH B07 and VHH B10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Blachier, S., Vaney, M.C., Fernandez, I., Arbabian, A., Rey, F.A.R., Haouz, A., Brelot, A. 2.69 X-RAY DIFFRACTION 0.255 0.220 False True IGHV1 NA NA None None None None None 9r19 G NA 0 A protein NA processed angiotensin-converting enzyme 2 HYDROLASE 09/17/25 Crystal structure of human ACE2 in complex with VHH B07 and VHH B10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Blachier, S., Vaney, M.C., Fernandez, I., Arbabian, A., Rey, F.A.R., Haouz, A., Brelot, A. 2.69 X-RAY DIFFRACTION 0.255 0.220 False True IGHV1 NA NA None None None None None 9r19 H NA 0 B protein NA processed angiotensin-converting enzyme 2 HYDROLASE 09/17/25 Crystal structure of human ACE2 in complex with VHH B07 and VHH B10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Blachier, S., Vaney, M.C., Fernandez, I., Arbabian, A., Rey, F.A.R., Haouz, A., Brelot, A. 2.69 X-RAY DIFFRACTION 0.255 0.220 False True IGHV1 NA NA None None None None None 9r19 I NA 0 C protein NA processed angiotensin-converting enzyme 2 HYDROLASE 09/17/25 Crystal structure of human ACE2 in complex with VHH B07 and VHH B10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Blachier, S., Vaney, M.C., Fernandez, I., Arbabian, A., Rey, F.A.R., Haouz, A., Brelot, A. 2.69 X-RAY DIFFRACTION 0.255 0.220 False True IGHV1 NA NA None None None None None 9dbx H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Structure of AG11-2F01 Fab in complex with A/Solomon Islands/3/2006 (H1N1) influenza virus hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Mou, Z., Lei, R., Dai, X., Wu, N. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9dbx W X 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Structure of AG11-2F01 Fab in complex with A/Solomon Islands/3/2006 (H1N1) influenza virus hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Mou, Z., Lei, R., Dai, X., Wu, N. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9dbx Y Z 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Structure of AG11-2F01 Fab in complex with A/Solomon Islands/3/2006 (H1N1) influenza virus hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Mou, Z., Lei, R., Dai, X., Wu, N. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9hls C NA 0 B protein NA entry-fusion complex protein opg094 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07, VHH B01 and VHH C05 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.2 X-RAY DIFFRACTION 0.292 0.237 False True IGHV1 NA NA None None None None None 9hls D NA 0 B | A protein | protein NA | NA entry-fusion complex protein opg094 | virion membrane protein opg143 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07, VHH B01 and VHH C05 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve | vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.2 X-RAY DIFFRACTION 0.292 0.237 False True IGHV1 NA NA None None None None None 9hls J NA 0 G protein NA entry-fusion complex protein opg094 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07, VHH B01 and VHH C05 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.2 X-RAY DIFFRACTION 0.292 0.237 False True IGHV1 NA NA None None None None None 9hls H NA 0 G protein NA entry-fusion complex protein opg094 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07, VHH B01 and VHH C05 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.2 X-RAY DIFFRACTION 0.292 0.237 False True IGHV1 NA NA None None None None None 9hls I NA 0 G | F protein | protein NA | NA entry-fusion complex protein opg094 | virion membrane protein opg143 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07, VHH B01 and VHH C05 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve | vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.2 X-RAY DIFFRACTION 0.292 0.237 False True IGHV1 NA NA None None None None None 9hls E NA 0 B protein NA entry-fusion complex protein opg094 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07, VHH B01 and VHH C05 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.2 X-RAY DIFFRACTION 0.292 0.237 False True IGHV1 NA NA None None None None None 9hpa D NA 0 B | A protein | protein NA | NA entry-fusion complex protein opg094 | virion membrane protein opg143 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07 and VHH E12 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve | vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.1 X-RAY DIFFRACTION 0.265 0.223 False True IGHV1 NA NA None None None None None 9hpa C NA 0 B protein NA entry-fusion complex protein opg094 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07 and VHH E12 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.1 X-RAY DIFFRACTION 0.265 0.223 False True IGHV1 NA NA None None None None None 9hpa H NA 0 F | E protein | protein NA | NA entry-fusion complex protein opg094 | virion membrane protein opg143 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07 and VHH E12 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve | vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.1 X-RAY DIFFRACTION 0.265 0.223 False True IGHV1 NA NA None None None None None 9hpa G NA 0 F protein NA entry-fusion complex protein opg094 VIRAL PROTEIN 09/03/25 Structure of A16/G9 (vaccinia virus) in complex with VHH D07 and VHH E12 Vaccinia virus Western Reserve; Vicugna pacos vicugna pacos vaccinia virus western reserve Vernuccio, R., Meola, A., Guardado-Calvo, P. 3.1 X-RAY DIFFRACTION 0.265 0.223 False True IGHV1 NA NA None None None None None 9msn A B 0 J | K protein | protein NA | NA protein opg161 | protein opg161 IMMUNE SYSTEM 09/10/25 Crystal structure of MPXV A35R in complex with neutralizing antibody EV35-2 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Yuan, M., Zhu, X., Wilson, I.A. 2.92 X-RAY DIFFRACTION 0.307 0.280 False True IGHV1 IGKV3 Kappa None None None None None 9msn H L 0 E | F protein | protein NA | NA protein opg161 | protein opg161 IMMUNE SYSTEM 09/10/25 Crystal structure of MPXV A35R in complex with neutralizing antibody EV35-2 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Yuan, M., Zhu, X., Wilson, I.A. 2.92 X-RAY DIFFRACTION 0.307 0.280 False True IGHV1 IGKV3 Kappa None None None None None 9mso H L 0 I | G protein | protein NA | NA protein opg161 | protein opg161 IMMUNE SYSTEM 09/10/25 Crystal structure of MPXV A35R in complex with neutralizing antibody EV35-6 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Yuan, M., Zhu, X., Wilson, I.A. 3.18 X-RAY DIFFRACTION 0.251 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9mso A B 0 F | E protein | protein NA | NA protein opg161 | protein opg161 IMMUNE SYSTEM 09/10/25 Crystal structure of MPXV A35R in complex with neutralizing antibody EV35-6 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Yuan, M., Zhu, X., Wilson, I.A. 3.18 X-RAY DIFFRACTION 0.251 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9msp H L 0 F | E protein | protein NA | NA protein opg161 | protein opg161 IMMUNE SYSTEM 09/10/25 Crystal structure of MPXV A35R in complex with neutralizing antibody EV35-7 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Yuan, M., Wilson, I.A. 2.19 X-RAY DIFFRACTION 0.250 0.211 False True IGHV3 IGKV1 Kappa None None None None None 9msp C D 0 B | A protein | protein NA | NA protein opg161 | protein opg161 IMMUNE SYSTEM 09/10/25 Crystal structure of MPXV A35R in complex with neutralizing antibody EV35-7 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Yuan, M., Wilson, I.A. 2.19 X-RAY DIFFRACTION 0.250 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8s72 X Y 0 N protein NA short neurotoxin 1 ANTITOXIN 09/10/25 Crystal structure of neutralizing Fab Eq4.Dp46-3D from equine antivenom bound to a consensus short chain three finger alpha-neurotoxin. Equus caballus; synthetic construct equus caballus equus caballus synthetic construct Ayres, F., Wibmer, C.K. 2.78 X-RAY DIFFRACTION 0.250 0.228 False True unknown unknown unknown None None None None None 8s72 H L 0 A protein NA short neurotoxin 1 ANTITOXIN 09/10/25 Crystal structure of neutralizing Fab Eq4.Dp46-3D from equine antivenom bound to a consensus short chain three finger alpha-neurotoxin. Equus caballus; synthetic construct equus caballus equus caballus synthetic construct Ayres, F., Wibmer, C.K. 2.78 X-RAY DIFFRACTION 0.250 0.228 False True unknown unknown unknown None None None None None 8yfo N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/03/25 A cryo-EM structure of Ac-LA-PTH-PTH1R-Gs complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, L., He, Q., Yuan, Q., Gu, Y., He, X., Shan, H., Xu, H.E. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8yg4 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/03/25 A cryo-EM structure of LA-PTH-R1-PTH1R-Gs complex structure Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, L., He, Q., Yuan, Q., Gu, Y., He, X., Shan, H., Xu, H.E. 2.59 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zrd C NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/10/25 The complex structure of SARS-CoV-2 RBD and llama single-domain antibody S4 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Chen, L. 2.715 X-RAY DIFFRACTION 0.295 0.235 False True IGHV3 NA NA None None None None None 8zrd D NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/10/25 The complex structure of SARS-CoV-2 RBD and llama single-domain antibody S4 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Chen, L. 2.715 X-RAY DIFFRACTION 0.295 0.235 False True IGHV3 NA NA None None None None None 9b6w D E 0 A protein NA envelope protein VIRUS/IMMUNE SYSTEM 09/03/25 Envelope protein ASU of YFV-ES504 with YFV-17D DIII in complex with 2C9 Fab Mus musculus; Yellow fever virus mus musculus mus musculus yellow fever virus Bibby, S., James, J., Modhiran, N., Watterson, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV14 Kappa None None None None None 9b6w F G 0 B protein NA envelope protein VIRUS/IMMUNE SYSTEM 09/03/25 Envelope protein ASU of YFV-ES504 with YFV-17D DIII in complex with 2C9 Fab Mus musculus; Yellow fever virus mus musculus mus musculus yellow fever virus Bibby, S., James, J., Modhiran, N., Watterson, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV14 Kappa None None None None None 9b6w H I 0 C protein NA envelope protein VIRUS/IMMUNE SYSTEM 09/03/25 Envelope protein ASU of YFV-ES504 with YFV-17D DIII in complex with 2C9 Fab Mus musculus; Yellow fever virus mus musculus mus musculus yellow fever virus Bibby, S., James, J., Modhiran, N., Watterson, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV14 Kappa None None None None None 9dd6 H L 0 E protein NA glycoprotein b VIRAL PROTEIN 09/10/25 Cryo-EM structure of neutralizing murine antibody WS.HSV-1.24 in complex with HSV-1 glycoprotein B trimer gB-Ecto.516P.531E Human alphaherpesvirus 1; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV9 Kappa None None None None None 9dd6 I M 0 F protein NA glycoprotein b VIRAL PROTEIN 09/10/25 Cryo-EM structure of neutralizing murine antibody WS.HSV-1.24 in complex with HSV-1 glycoprotein B trimer gB-Ecto.516P.531E Human alphaherpesvirus 1; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV9 Kappa None None None None None 9dd6 J N 0 G protein NA glycoprotein b VIRAL PROTEIN 09/10/25 Cryo-EM structure of neutralizing murine antibody WS.HSV-1.24 in complex with HSV-1 glycoprotein B trimer gB-Ecto.516P.531E Human alphaherpesvirus 1; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 Roark, R.S., Shapiro, L.S., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV9 Kappa None None None None None 9dd7 I M 0 E protein NA glycoprotein b VIRAL PROTEIN 09/10/25 Cryo-EM structure of neutralizing human antibody D48 in complex with HSV-1 glycoprotein B trimer gB-Ecto.516P.531E.DS Homo sapiens; Human alphaherpesvirus 1 homo sapiens homo sapiens human alphaherpesvirus 1 Roark, R.S., Shapiro, L., Kwong, P.D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dd7 J N 0 F protein NA glycoprotein b VIRAL PROTEIN 09/10/25 Cryo-EM structure of neutralizing human antibody D48 in complex with HSV-1 glycoprotein B trimer gB-Ecto.516P.531E.DS Homo sapiens; Human alphaherpesvirus 1 homo sapiens homo sapiens human alphaherpesvirus 1 Roark, R.S., Shapiro, L., Kwong, P.D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dd7 K O 0 G protein NA glycoprotein b VIRAL PROTEIN 09/10/25 Cryo-EM structure of neutralizing human antibody D48 in complex with HSV-1 glycoprotein B trimer gB-Ecto.516P.531E.DS Homo sapiens; Human alphaherpesvirus 1 homo sapiens homo sapiens human alphaherpesvirus 1 Roark, R.S., Shapiro, L., Kwong, P.D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9e7k C NA 0 A | B protein | protein NA | NA isoform 3 of ubiquitin carboxyl-terminal hydrolase isozymel5 | proteasomal ubiquitin receptor adrm1 HYDROLASE 09/03/25 Crystal structure of the UCH37 RPN13 DEUBAD complex bound to an inhibitory nanobody in the canonical ubiquitin binding site Camelidae mixed library; Homo sapiens camelidae mixed library homo sapiens | homo sapiens Patel, R., Li, Y., Strieter, E., Das, C. 2.41 X-RAY DIFFRACTION 0.271 0.235 False True IGHV1 NA NA None None None None None 9e9s N NA 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 09/03/25 Cryo-EM structure of the PGD2-bound prostaglandin D2 receptor (DP1)-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Davoudinasab, B., Cherezov, V., Han, G.W., KIm, D. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ei5 H L 0 A protein NA prostaglandin d2 receptor,soluble cytochrome b562 MEMBRANE PROTEIN/Immune System 09/03/25 Cryo-EM structure of Apo form of prostaglandin D2 receptor (DP1)-bRIL-Fab complex Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Davoudinasab, B., Cherezov, V., Han, G.W. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ei5 K NA 0 NA NA NA NA MEMBRANE PROTEIN/Immune System 09/03/25 Cryo-EM structure of Apo form of prostaglandin D2 receptor (DP1)-bRIL-Fab complex Homo sapiens; synthetic construct synthetic construct Davoudinasab, B., Cherezov, V., Han, G.W. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ejc D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 VIRAL PROTEIN/SIGNALING PROTEIN 09/03/25 Cryo-EM Structure of CXCL1-KSHV ORF74-Gi-scFv16 Complex Homo sapiens; Human gammaherpesvirus 8; Mus musculus mus musculus homo sapiens | homo sapiens Sahoo, B., Seo, H.D., Dai, X., Jung, J. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9gjv H L 0 NA NA NA NA PROTEIN BINDING 09/03/25 Fab fragment of an antibody that recognises alpha-1 antitrypsin Mus musculus mus musculus mus musculus Aldobiyan, I., Lomas, D.A., Irving, J.A. 2.2 X-RAY DIFFRACTION 0.262 0.244 False False IGHV14 IGKV6 Kappa None None None None None 9gmu C NA 0 B protein NA integrin alpha-m IMMUNE SYSTEM 09/10/25 Structure ofhuman aM ligand binding domain in complex with the aCR3 nanobody Homo sapiens; Lama glama lama glama homo sapiens Lorentzen, J., Andersen, G.R. 3.8 X-RAY DIFFRACTION 0.298 0.242 False True IGHV1 NA NA None None None None None 9gmu D NA 0 A protein NA integrin alpha-m IMMUNE SYSTEM 09/10/25 Structure ofhuman aM ligand binding domain in complex with the aCR3 nanobody Homo sapiens; Lama glama lama glama homo sapiens Lorentzen, J., Andersen, G.R. 3.8 X-RAY DIFFRACTION 0.298 0.242 False True IGHV1 NA NA None None None None None 9ijr H h 0 C | A protein | protein NA | NA beta-arrestin-1 | g-protein coupled receptor 52 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/03/25 Cryo-EM structure of the orphan GPR52 beta-arrestin 1 complex bound to ligand c17 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Lin, X., Xu, F. 3.86 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ijs H h 0 C | A protein | protein NA | NA beta-arrestin-1 | g-protein coupled receptor 52 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/03/25 Cryo-EM structure of the orphan GPR52 bound to beta-arrestin 1 in ligand-free state Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Lin, X., Xu, F. 3.64 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9imx C NA 0 B protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Immune complex of HEV E2s and P1-5B nanobody Hepatitis E virus (strain Pakistan); Vicugna pacos vicugna pacos hepatitis e virus (strain pakistan) Tingting, L., Wenhui, X., Ying, G., Shaowei, L. 2.2 X-RAY DIFFRACTION 0.245 0.217 False True IGHV1 NA NA None None None None None 9imx D NA 0 A protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Immune complex of HEV E2s and P1-5B nanobody Hepatitis E virus (strain Pakistan); Vicugna pacos vicugna pacos hepatitis e virus (strain pakistan) Tingting, L., Wenhui, X., Ying, G., Shaowei, L. 2.2 X-RAY DIFFRACTION 0.245 0.217 False True IGHV1 NA NA None None None None None 9imx G NA 0 F protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Immune complex of HEV E2s and P1-5B nanobody Hepatitis E virus (strain Pakistan); Vicugna pacos vicugna pacos hepatitis e virus (strain pakistan) Tingting, L., Wenhui, X., Ying, G., Shaowei, L. 2.2 X-RAY DIFFRACTION 0.245 0.217 False True IGHV1 NA NA None None None None None 9imx H NA 0 E protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Immune complex of HEV E2s and P1-5B nanobody Hepatitis E virus (strain Pakistan); Vicugna pacos vicugna pacos hepatitis e virus (strain pakistan) Tingting, L., Wenhui, X., Ying, G., Shaowei, L. 2.2 X-RAY DIFFRACTION 0.245 0.217 False True IGHV1 NA NA None None None None None 9j9b H L 0 C protein NA mitochondrial import inner membrane translocase subunittim44,l-lactate dehydrogenase (cytochrome),sfgfp PROTEIN TRANSPORT 09/10/25 Substrate-engaged TIM23 complex from yeast Saccharomyces cerevisiae S288C; synthetic construct saccharomyces cerevisiae s288c saccharomyces cerevisiae s288c saccharomyces cerevisiae s288c, syntheticconstruct Yang, Y.Q., Wang, G.P. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 9jcl N NA 0 A | B | G protein | protein | protein NA | NA | NA gnas complex locus | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/10/25 ADP-bound purinergic receptor 1 with L266P mutant in complex with miniGs/q Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Gu, Q.C., Wang, T.X., Tang, W.Q. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9je3 E F 0 X carbohydrate GLC ALPHA-D-GLUCOSE IMMUNE SYSTEM 09/03/25 Structure of #2-911 Fab in complex with MEDI8852 Fab Homo sapiens; Mus musculus mus musculus mus musculus Itou, H., Sano, K., Ainai, A., Suzuki, T. 2.374 X-RAY DIFFRACTION 0.254 0.200 False True IGHV1 IGLV1 Lambda None None None None None 9je3 G H 0 X carbohydrate GLC ALPHA-D-GLUCOSE IMMUNE SYSTEM 09/03/25 Structure of #2-911 Fab in complex with MEDI8852 Fab Homo sapiens; Mus musculus homo sapiens homo sapiens Itou, H., Sano, K., Ainai, A., Suzuki, T. 2.374 X-RAY DIFFRACTION 0.254 0.200 False True IGHV6 IGKV1 Kappa None None None None None 9je3 A B 0 NA NA NA NA IMMUNE SYSTEM 09/03/25 Structure of #2-911 Fab in complex with MEDI8852 Fab Homo sapiens; Mus musculus mus musculus mus musculus Itou, H., Sano, K., Ainai, A., Suzuki, T. 2.374 X-RAY DIFFRACTION 0.254 0.200 False True IGHV1 IGLV1 Lambda None None None None None 9je3 C D 0 NA NA NA NA IMMUNE SYSTEM 09/03/25 Structure of #2-911 Fab in complex with MEDI8852 Fab Homo sapiens; Mus musculus homo sapiens homo sapiens Itou, H., Sano, K., Ainai, A., Suzuki, T. 2.374 X-RAY DIFFRACTION 0.254 0.200 False True IGHV6 IGKV1 Kappa None None None None None 9jeb A a 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv N1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Guo, K., Zhang, N., Guo, Y. 2.3 X-RAY DIFFRACTION 0.206 0.178 True True unknown unknown unknown None None None None None 9jeb C c 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv N1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Guo, K., Zhang, N., Guo, Y. 2.3 X-RAY DIFFRACTION 0.206 0.178 True True unknown unknown unknown None None None None None 9jed S s 0 A | D protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/10/25 Cryo-EM structure of Histamine-bound Histamine receptor 4 H4R G protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Jin, S., Zhang, H., Jiang, Y. 2.58 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jzq A B 0 E protein NA envelope glycoprotein e VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 The glycoprotein E of Varicella-Zoster Virus in complex with WLL-1/WLL-28 Fab Homo sapiens; Varicella-zoster virus (strain Oka vaccine) homo sapiens homo sapiens varicella-zoster virus (strain oka vaccine) Wang, L., Zhang, N., Guo, Y. 3.48 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 9jzq C D 0 E protein NA envelope glycoprotein e VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 The glycoprotein E of Varicella-Zoster Virus in complex with WLL-1/WLL-28 Fab Homo sapiens; Varicella-zoster virus (strain Oka vaccine) homo sapiens homo sapiens varicella-zoster virus (strain oka vaccine) Wang, L., Zhang, N., Guo, Y. 3.48 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9lxr C E 0 B | R protein | protein NA | NA beta-arrestin-1 | parathyroid hormone/parathyroid hormone-related peptidereceptor MEMBRANE PROTEIN 09/10/25 A Cryo-EM structure of LA-PTH-PTH1R-Beta-arrestin1 complex (state 1 conformation) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Zhao, L., Yuan, Q. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o99 A NA 0 NA NA NA NA PROTEIN BINDING 09/10/25 Structure of the IL-2 Surrogate Cytokine Agonist DR638 Lama glama lama glama Trenker, R., Vivona, S., Lupardus, P.J. 1.8 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 NA NA None None None None None 9o9a A NA 0 NA NA NA NA PROTEIN BINDING 09/10/25 Structure of the IL-18 Surrogate Cytokine Agonist DR3087 Lama glama lama glama Trenker, R., Vivona, S., Lupardus, P.J. 2.4 X-RAY DIFFRACTION 0.280 0.241 False True IGHV1 NA NA None None None None None 9o9a B NA 0 NA NA NA NA PROTEIN BINDING 09/10/25 Structure of the IL-18 Surrogate Cytokine Agonist DR3087 Lama glama lama glama Trenker, R., Vivona, S., Lupardus, P.J. 2.4 X-RAY DIFFRACTION 0.280 0.241 False True IGHV1 NA NA None None None None None 9o9b A NA 0 NA NA NA NA PROTEIN BINDING 09/10/25 Structure of the IL-18 Surrogate Cytokine Agonist DR3097 Lama glama lama glama Trenker, R., Vivona, S., Lupardus, P.J. 2.8 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 9o9b B NA 0 NA NA NA NA PROTEIN BINDING 09/10/25 Structure of the IL-18 Surrogate Cytokine Agonist DR3097 Lama glama lama glama Trenker, R., Vivona, S., Lupardus, P.J. 2.8 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 9o9c B NA 0 NA NA NA NA PROTEIN BINDING 09/10/25 Structure of the IL-18 Surrogate Cytokine Agonist DR3085 Lama glama lama glama Trenker, R., Vivona, S., Lupardus, P.J. 3.8 X-RAY DIFFRACTION 0.291 0.235 False True IGHV1 NA NA None None None None None 9o9c A NA 0 NA NA NA NA PROTEIN BINDING 09/10/25 Structure of the IL-18 Surrogate Cytokine Agonist DR3085 Lama glama lama glama Trenker, R., Vivona, S., Lupardus, P.J. 3.8 X-RAY DIFFRACTION 0.291 0.235 False True IGHV1 NA NA None None None None None 9pdy D G 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Human antibody Fab MPV510 bound to hMPV DsCav-ES2-IPDS F protein Homo sapiens; human metapneumovirus homo sapiens homo sapiens human metapneumovirus Ghazi Esfahani, N., Mousa, J., Khalil, A.M. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pdy E H 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Human antibody Fab MPV510 bound to hMPV DsCav-ES2-IPDS F protein Homo sapiens; human metapneumovirus homo sapiens homo sapiens human metapneumovirus Ghazi Esfahani, N., Mousa, J., Khalil, A.M. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pdy F I 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/03/25 Human antibody Fab MPV510 bound to hMPV DsCav-ES2-IPDS F protein Homo sapiens; human metapneumovirus homo sapiens homo sapiens human metapneumovirus Ghazi Esfahani, N., Mousa, J., Khalil, A.M. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9pwn H L 0 A peptide NA trem-2 stalk peptide IMMUNE SYSTEM 09/10/25 Crystal structure of Fabs 7411 in complex with TREM2 peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Arndt, J.W., Chao, Q., Cooke, H.A., Almeida, A.D.S. 1.8 X-RAY DIFFRACTION 0.218 0.178 False True IGHV3 IGKV1 Kappa None None None None None 9px5 H L 0 A protein NA maltose/maltodextrin-binding periplasmic protein,triggeringreceptor expressed on myeloid cells 2 IMMUNE SYSTEM 09/10/25 Crystal structure of Fab 7268 in complex with MBP-TREM2 Ig domain fusion Escherichia coli; Homo sapiens homo sapiens homo sapiens escherichia coli, homo sapiens Arndt, J.W., Chao, Q., Cooke, H.A., Almeida, A.D.S. 3.7 X-RAY DIFFRACTION 0.268 0.248 False True IGHV4 IGKV1 Kappa None None None None None 9q9n d NA 0 B protein NA glycoprotein b VIRAL PROTEIN 09/03/25 HSV-1 prefusion glycoprotein B bound by Nb1_gbHSV Human alphaherpesvirus 1 strain 17; Vicugna pacos vicugna pacos human alphaherpesvirus 1 strain 17 Vollmer, B., Mulvaney, T., Ebel, H., Nentwig, J., Gruenewald, K. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9q9n e NA 0 C protein NA glycoprotein b VIRAL PROTEIN 09/03/25 HSV-1 prefusion glycoprotein B bound by Nb1_gbHSV Human alphaherpesvirus 1 strain 17; Vicugna pacos vicugna pacos human alphaherpesvirus 1 strain 17 Vollmer, B., Mulvaney, T., Ebel, H., Nentwig, J., Gruenewald, K. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9q9n f NA 0 A protein NA glycoprotein b VIRAL PROTEIN 09/03/25 HSV-1 prefusion glycoprotein B bound by Nb1_gbHSV Human alphaherpesvirus 1 strain 17; Vicugna pacos vicugna pacos human alphaherpesvirus 1 strain 17 Vollmer, B., Mulvaney, T., Ebel, H., Nentwig, J., Gruenewald, K. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9q9s d NA 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 09/03/25 HSV-2 prefusion glycoprotein B bound by Nb1_gbHSV Human herpesvirus 2 strain 333; Vicugna pacos vicugna pacos human herpesvirus 2 strain 333 Vollmer, B., Mulvaney, T., Ebel, H., Nentwig, J., Gruenewald, K. 2.7 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9q9s e NA 0 C protein NA envelope glycoprotein b VIRAL PROTEIN 09/03/25 HSV-2 prefusion glycoprotein B bound by Nb1_gbHSV Human herpesvirus 2 strain 333; Vicugna pacos vicugna pacos human herpesvirus 2 strain 333 Vollmer, B., Mulvaney, T., Ebel, H., Nentwig, J., Gruenewald, K. 2.7 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9q9s f NA 0 B protein NA envelope glycoprotein b VIRAL PROTEIN 09/03/25 HSV-2 prefusion glycoprotein B bound by Nb1_gbHSV Human herpesvirus 2 strain 333; Vicugna pacos vicugna pacos human herpesvirus 2 strain 333 Vollmer, B., Mulvaney, T., Ebel, H., Nentwig, J., Gruenewald, K. 2.7 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9s35 B NA 0 A protein NA gdp-mannose transporter TRANSPORT PROTEIN 09/03/25 Cryo-EM structure of Candida albicans Vrg4 bound to an inhibitory nanobody. Candida albicans; Lama glama lama glama candida albicans Deme, J.C., Parker, J.L., Lea, S.M., Newstead, S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9s36 B NA 0 A protein NA gdp-mannose transporter TRANSPORT PROTEIN 09/03/25 Cryo-EM structure of Candida albicans Vrg4 bound to an inhibitory nanobody and GDP-Mannose. Candida albicans; Lama glama lama glama candida albicans Deme, J.C., Parker, J.L., Lea, S.M., Newstead, S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9s38 B NA 0 D protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 09/03/25 Structure of LGR4 with NB21 Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 3.94 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9s38 A NA 0 D protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 09/03/25 Structure of LGR4 with NB21 Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9u9v N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/03/25 beta2-adrenergic receptor in complex with methamphetamine Homo sapiens homo sapiens homo sapiens | homo sapiens Shan, W., Shan, W. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9uvi B A 0 C protein NA beta-2-microglobulin IMMUNE SYSTEM 09/03/25 Crystal structure of beta 2 microglobulin in complex with antibody BBM.1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Wei, P.C., Wu, J.J. 2.5 X-RAY DIFFRACTION 0.246 0.197 False True IGHV14 IGKV12 Kappa None None None None None 9br5 B A 0 NA NA NA NA IMMUNE SYSTEM 08/27/25 IL1RAP-specific Fab Mus musculus mus musculus mus musculus Mallett, T.C., Williams, J.C., Park, M. 2.9 X-RAY DIFFRACTION 0.265 0.216 False True IGHV1 IGKV4 Kappa None None None None None 9bx5 H L 0 P peptide NA p4 peptide from outer surface protein c IMMUNE SYSTEM 08/27/25 Human Fab 8C1 in complex with OspCA peptide P4 (residues 141-144) Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 1.57 X-RAY DIFFRACTION 0.170 0.142 False True IGHV1 IGKV1 Kappa None None None None None 9bx7 H L 0 P peptide NA p20 peptide from outer surface protein c IMMUNE SYSTEM/ANTIGEN 08/27/25 Fab 8C1 in complex with OspCA peptide P20 (residues 131-150) Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 1.7 X-RAY DIFFRACTION 0.197 0.176 False True IGHV1 IGKV1 Kappa None None None None None 9byf H L 0 A protein NA outer surface protein a IMMUNE SYSTEM/ANTIGEN 08/27/25 Fab 212-55 in complex with OspA Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 2.85 X-RAY DIFFRACTION 0.288 0.230 False True IGHV3 IGKV3 Kappa None None None None None 9c1s H L 0 D protein NA outer surface protein c IMMUNE SYSTEM/ANTIGEN 08/27/25 Fab F946 in complex with OspC type A Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 2.6 X-RAY DIFFRACTION 0.251 0.196 False True IGHV4 IGKV1 Kappa None None None None None 9c1s A B 0 C protein NA outer surface protein c IMMUNE SYSTEM/ANTIGEN 08/27/25 Fab F946 in complex with OspC type A Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 2.6 X-RAY DIFFRACTION 0.251 0.196 False True IGHV4 IGKV1 Kappa None None None None None 9c24 H L 0 D protein NA outer surface protein c IMMUNE SYSTEM 08/27/25 Fab F946 in complex with OspCB Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 2.8 X-RAY DIFFRACTION 0.288 0.234 False True IGHV4 IGKV1 Kappa None None None None None 9c24 A B 0 C protein NA outer surface protein c IMMUNE SYSTEM 08/27/25 Fab F946 in complex with OspCB Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 2.8 X-RAY DIFFRACTION 0.288 0.234 False True IGHV4 IGKV1 Kappa None None None None None 9c9k H L 0 NA NA NA NA IMMUNE SYSTEM 08/27/25 Anti-OspA Fab 319-33 Homo sapiens homo sapiens homo sapiens Rudolph, M.J., Mantis, N. 1.601 X-RAY DIFFRACTION 0.200 0.172 False True IGHV5 IGKV3 Kappa None None None None None 9cfd H L 0 P peptide NA outer surface protein c IMMUNE SYSTEM 08/27/25 Fab 8C1 in complex with OspCA peptide P15 (residues 132-146) Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 1.64 X-RAY DIFFRACTION 0.189 0.161 False True IGHV1 IGKV1 Kappa None None None None None 9l1j A NA 0 NA NA NA NA IMMUNE SYSTEM 08/27/25 sdAbB YERLA mutant Vicugna pacos vicugna pacos Caaveiro, J.M.M., Uto, Y., Tsumoto, K. 1.62 X-RAY DIFFRACTION 0.199 0.160 False True IGHV1 NA NA None None None None None 9l1k A NA 0 NA NA NA NA IMMUNE SYSTEM 08/27/25 sdAbA YERLS mutant Vicugna pacos vicugna pacos Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 1.57 X-RAY DIFFRACTION 0.170 0.136 False True IGHV3 NA NA None None None None None 9l1k B NA 0 NA NA NA NA IMMUNE SYSTEM 08/27/25 sdAbA YERLS mutant Vicugna pacos vicugna pacos Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 1.57 X-RAY DIFFRACTION 0.170 0.136 False True IGHV3 NA NA None None None None None 9l1k C NA 0 NA NA NA NA IMMUNE SYSTEM 08/27/25 sdAbA YERLS mutant Vicugna pacos vicugna pacos Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 1.57 X-RAY DIFFRACTION 0.170 0.136 False True IGHV3 NA NA None None None None None 9l1k D NA 0 NA NA NA NA IMMUNE SYSTEM 08/27/25 sdAbA YERLS mutant Vicugna pacos vicugna pacos Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 1.57 X-RAY DIFFRACTION 0.170 0.136 False True IGHV3 NA NA None None None None None 9md2 H L 0 A protein NA neuraminidase ind11 VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-6 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV17 Kappa None None None None None 9md2 E I 0 B protein NA neuraminidase ind11 VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-6 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV17 Kappa None None None None None 9md2 F J 0 C protein NA neuraminidase ind11 VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-6 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV17 Kappa None None None None None 9md2 G K 0 D protein NA neuraminidase ind11 VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-6 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV17 Kappa None None None None None 9md3 H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-12 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9md3 E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-12 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9md3 F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-12 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9md3 G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 5-12 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9md4 H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase complexed with mAb 5-16 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md4 E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase complexed with mAb 5-16 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md4 F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase complexed with mAb 5-16 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md4 G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase complexed with mAb 5-16 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md5 H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.2 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md5 E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.2 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md5 F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.2 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md5 G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.2 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9md6 H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.1 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9md6 E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.1 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9md6 F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.1 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9md6 G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/27/25 Neuraminidase in complex with mAb 6-23.1 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9miv H L 0 A protein NA glycoprotein g1 VIRAL PROTEIN 08/27/25 Native tagless Lassa virus spike complex pH 6.0 Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Katz, M., Cohen-Dvashi, H., Diskin, R. 2.02 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9miv D E 0 B protein NA glycoprotein g1 VIRAL PROTEIN 08/27/25 Native tagless Lassa virus spike complex pH 6.0 Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Katz, M., Cohen-Dvashi, H., Diskin, R. 2.02 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9miv F G 0 C protein NA glycoprotein g1 VIRAL PROTEIN 08/27/25 Native tagless Lassa virus spike complex pH 6.0 Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Katz, M., Cohen-Dvashi, H., Diskin, R. 2.02 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mj1 H L 0 A protein NA glycoprotein g1 VIRAL PROTEIN 08/27/25 Native tagless Lassa virus spike complex bound at pH 8.0 Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Katz, M., Cohen-Dvashi, H., Diskin, R. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mj1 D E 0 B protein NA glycoprotein g1 VIRAL PROTEIN 08/27/25 Native tagless Lassa virus spike complex bound at pH 8.0 Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Katz, M., Cohen-Dvashi, H., Diskin, R. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mj1 F G 0 C protein NA glycoprotein g1 VIRAL PROTEIN 08/27/25 Native tagless Lassa virus spike complex bound at pH 8.0 Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Katz, M., Cohen-Dvashi, H., Diskin, R. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9naq H L 0 A protein NA erythrocyte membrane protein 1 IMMUNE SYSTEM 08/27/25 Cryo-EM structure of 110_C4 Fab in complex with CIDRa1.7 PfEMP1 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Raghavan, S.S.R., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV10 Lambda None None None None None 9npg A B 0 C protein NA major allergen can f 1 ALLERGEN/IMMUNE SYSTEM 08/27/25 X-ray crystal structure of recombinant Can f 1-C100S in complex with human IgE mAb 12F3 Fab Canis lupus familiaris; Homo sapiens homo sapiens homo sapiens canis lupus familiaris Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 3.12 X-RAY DIFFRACTION 0.245 0.203 False True IGHV1 IGKV3 Kappa None None None None None 9npg D E 0 F protein NA major allergen can f 1 ALLERGEN/IMMUNE SYSTEM 08/27/25 X-ray crystal structure of recombinant Can f 1-C100S in complex with human IgE mAb 12F3 Fab Canis lupus familiaris; Homo sapiens homo sapiens homo sapiens canis lupus familiaris Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 3.12 X-RAY DIFFRACTION 0.245 0.203 False True IGHV1 IGKV3 Kappa None None None None None 9npg G H 0 I protein NA major allergen can f 1 ALLERGEN/IMMUNE SYSTEM 08/27/25 X-ray crystal structure of recombinant Can f 1-C100S in complex with human IgE mAb 12F3 Fab Canis lupus familiaris; Homo sapiens homo sapiens homo sapiens canis lupus familiaris Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 3.12 X-RAY DIFFRACTION 0.245 0.203 False True IGHV1 IGKV3 Kappa None None None None None 9npg K J 0 L protein NA major allergen can f 1 ALLERGEN/IMMUNE SYSTEM 08/27/25 X-ray crystal structure of recombinant Can f 1-C100S in complex with human IgE mAb 12F3 Fab Canis lupus familiaris; Homo sapiens homo sapiens homo sapiens canis lupus familiaris Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 3.12 X-RAY DIFFRACTION 0.245 0.203 False True IGHV1 IGKV3 Kappa None None None None None 9nph B A 0 C protein NA major allergen can f 1 ALLERGEN/IMMUNE SYSTEM 08/27/25 X-ray crystal structure of recombinant Can f 1 in complex with human IgE mAb 1J11 Fab Canis lupus familiaris; Homo sapiens homo sapiens homo sapiens canis lupus familiaris Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 2.592 X-RAY DIFFRACTION 0.261 0.215 False True IGHV3 IGLV3 Lambda None None None None None 9npi C B 0 A protein NA major allergen can f 1 ALLERGEN/IMMUNE SYSTEM 08/27/25 X-ray crystal structure of recombinant Can f 1 in complex with human IgE 12F3 Fab Canis lupus familiaris; Homo sapiens homo sapiens homo sapiens canis lupus familiaris Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 1.85 X-RAY DIFFRACTION 0.226 0.179 False True IGHV1 IGKV3 Kappa None None None None None 9ogt H L 0 A protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9ogt G I 0 A protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ogt K N 0 C protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9ogt J M 0 C protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ogt P R 0 E protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9ogt O Q 0 E protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ogu H I 0 A protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-dPG-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9ogu J K 0 A protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-dPG-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ogu M L 0 E protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-dPG-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9ogu N O 0 E protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-dPG-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ogu P Q 0 C protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-dPG-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9ogu R S 0 C protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/27/25 HIV-1 Env BG505 SOSIP.664-dPG-His in complex with PGT122 and 3BNC117 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Andrade, T.G., Ozorowski, G., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9p0x H L 0 T | X protein | protein NA | NA tissue factor,maltose/maltodextrin-binding periplasmicprotein | factor x light chain BLOOD CLOTTING 08/27/25 Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab (nanodisc-subtracted) Escherichia coli; Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens, escherichia coli | homo sapiens Photenhauer, A.L., Sedzro, J.C., Ohi, M.D., Morrissey, J.H. 3.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 9pyf D A 0 NA NA NA NA PROTEIN BINDING 08/27/25 uPA Inhibitory Fab AB2 Complex Homo sapiens homo sapiens homo sapiens Anderson, K.J., Bohn, M.F. 2.9 X-RAY DIFFRACTION 0.300 0.228 False True IGHV3 IGKV2 Kappa None None None None None 9pyf H I 0 NA NA NA NA PROTEIN BINDING 08/27/25 uPA Inhibitory Fab AB2 Complex Homo sapiens homo sapiens homo sapiens Anderson, K.J., Bohn, M.F. 2.9 X-RAY DIFFRACTION 0.300 0.228 False True IGHV3 IGKV2 Kappa None None None None None 9pzi D C 0 NA NA NA NA IMMUNE SYSTEM/TOXIN 08/20/25 Crystal Structure of synthetic antibody COP-2 in complex with the C-terminal domain of Clostridium perfringens enterotoxin Clostridium perfringens; Homo sapiens homo sapiens homo sapiens Vecchio, A.J., Ogbu, C.P., Kapoor, S. 2.5 X-RAY DIFFRACTION 0.225 0.178 False True IGHV3 IGKV1 Kappa None None None None None 9pzi B A 0 NA NA NA NA IMMUNE SYSTEM/TOXIN 08/20/25 Crystal Structure of synthetic antibody COP-2 in complex with the C-terminal domain of Clostridium perfringens enterotoxin Clostridium perfringens; Homo sapiens homo sapiens homo sapiens Vecchio, A.J., Ogbu, C.P., Kapoor, S. 2.5 X-RAY DIFFRACTION 0.225 0.178 False True IGHV3 IGKV1 Kappa None None None None None 9pzi F E 0 G protein NA heat-labile enterotoxin b chain IMMUNE SYSTEM/TOXIN 08/20/25 Crystal Structure of synthetic antibody COP-2 in complex with the C-terminal domain of Clostridium perfringens enterotoxin Clostridium perfringens; Homo sapiens homo sapiens homo sapiens clostridium perfringens Vecchio, A.J., Ogbu, C.P., Kapoor, S. 2.5 X-RAY DIFFRACTION 0.225 0.178 False True IGHV3 IGKV1 Kappa None None None None None 9d41 H L 0 A protein NA borealin IMMUNE SYSTEM 08/20/25 Crystal structure of N-terminal domain of Borealin (20-88) in complex with synthetic antibody fragment Homo sapiens homo sapiens homo sapiens homo sapiens Filippova, E.V., Hou, J., Mukherjee, S., Kossiakoff, A.A. 1.84 X-RAY DIFFRACTION 0.197 0.155 False True IGHV3 IGKV1 Kappa None None None None None 9ebh E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/20/25 Human adenosine A3 receptor Gi1 complex bound to adenosine Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, L., Mobbs, J.I., Glukhova, A., Thal, D.M. 3.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ebi N NA 0 A | B | G protein | protein | protein NA | NA | NA mini-gs/i chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 08/20/25 Human adenosine A3 receptor Gi complex (mini-Gsi chimera) bound to Piclidenoson (CF101, IB-MECA) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Zhang, L., Mobbs, J.I., Glukhova, A., Thal, D.M. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ecx H L 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 Crystal structure of the SARS-CoV-2 NTD-targeted neutralizing antibody WRAIR-2008 Homo sapiens homo sapiens homo sapiens Jensen, J.L., Joyce, M.G. 2.67 X-RAY DIFFRACTION 0.289 0.223 False True IGHV1 IGKV2 Kappa None None None None None 9ecx C D 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 Crystal structure of the SARS-CoV-2 NTD-targeted neutralizing antibody WRAIR-2008 Homo sapiens homo sapiens homo sapiens Jensen, J.L., Joyce, M.G. 2.67 X-RAY DIFFRACTION 0.289 0.223 False True IGHV1 IGKV2 Kappa None None None None None 9ecy H L 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 Crystal structure of the SARS-CoV-2 NTD-targeted neutralizing antibody WRAIR-2039 Homo sapiens homo sapiens homo sapiens Sankhala, R.S., Jensen, J.L., Joyce, M.G. 1.54 X-RAY DIFFRACTION 0.194 0.157 False True IGHV1 IGLV1 Lambda None None None None None 9ecz H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 spike protein in complex with human neutralizing antibody WRAIR-2008 (focused refinement of NTD and WRAIR-2008) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Thomas, P.V., Joyce, M.G. 3.89 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9gff H L 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P10015 Homo sapiens homo sapiens homo sapiens Minici, C., Degano, M. 2.8 X-RAY DIFFRACTION 0.235 0.209 False True IGHV1 IGKV1 Kappa None None None None None 9gfg H L 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P3129 Homo sapiens homo sapiens homo sapiens Minici, C., Degano, M. 2.3 X-RAY DIFFRACTION 0.246 0.220 False True IGHV1 IGKV1 Kappa None None None None None 9gfg A B 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P3129 Homo sapiens homo sapiens homo sapiens Minici, C., Degano, M. 2.3 X-RAY DIFFRACTION 0.246 0.220 False True IGHV1 IGKV1 Kappa None None None None None 9gfg C D 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P3129 Homo sapiens homo sapiens homo sapiens Minici, C., Degano, M. 2.3 X-RAY DIFFRACTION 0.246 0.220 False True IGHV1 IGKV1 Kappa None None None None None 9gfg E F 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P3129 Homo sapiens homo sapiens homo sapiens Minici, C., Degano, M. 2.3 X-RAY DIFFRACTION 0.246 0.220 False True IGHV1 IGKV1 Kappa None None None None None 9gfh H L 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P1173 Homo sapiens homo sapiens homo sapiens Cocomazzi, P.G., Degano, M. 2.72 X-RAY DIFFRACTION 0.244 0.214 False True IGHV5 IGKV1 Kappa None None None None None 9gfh A B 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P1173 Homo sapiens homo sapiens homo sapiens Cocomazzi, P.G., Degano, M. 2.72 X-RAY DIFFRACTION 0.244 0.214 False True IGHV5 IGKV1 Kappa None None None None None 9gfh C D 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P1173 Homo sapiens homo sapiens homo sapiens Cocomazzi, P.G., Degano, M. 2.72 X-RAY DIFFRACTION 0.244 0.214 False True IGHV5 IGKV1 Kappa None None None None None 9gfh E F 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 BCR Fab from the subset 1 chronic lymphocytic leukaemia case P1173 Homo sapiens homo sapiens homo sapiens Cocomazzi, P.G., Degano, M. 2.72 X-RAY DIFFRACTION 0.244 0.214 False True IGHV5 IGKV1 Kappa None None None None None 9gfl H L 0 NA NA NA NA IMMUNE SYSTEM 08/20/25 Crystal structure of ASO binding Fab fragment Homo sapiens homo sapiens homo sapiens Hsia, H.-E., Zanini, C., Simonneau, C., Fraidling, J., Kraft, T., Mayer, K., Sommer, A., Indlekofer, A., Wirth, T., Benz, J., Georges, G., Langer, L.M., Gassner, C., Larraillet, V., Manso, M., Ravn, J., Hofer, K., Emrich, T., Niewoehner, J., Schumacher, F., Brinkmann, U. 1.68 X-RAY DIFFRACTION 0.248 0.209 False True IGHV1 IGKV2 Kappa None None None None None 9irb H L 0 A protein NA solute carrier family 15 member 4 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/20/25 CryoEM structure of hSLC15A4+Fab107 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, Y.L., Zhang, Q.X., Gao, P. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9irc H L 0 A protein NA solute carrier family 15 member 4 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/20/25 CyroEM structure of hSLC15A4+TASL+Fab235 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, Y.L., Zhang, Q.X., Gao, P. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k0c H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structural of human taurine transporter TauT in an apo state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k0n H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter TauT bound with beta-alanine in an occluded state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k0o H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter TauT bound with GAA in an intermediate state during the transport cycle Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k1b H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter TauT bound with taurine in an occluded state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k1f H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter TauT bound with GABA in an intermediate conformation in the transport cycle Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k1i H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of huamn taurine transporter bound with I4AA in inward-open state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k1v H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter bound with 5AVA in an inward-open state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k1x H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter TauT bound with GES in an occluded state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k1z H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter bound with nipecotic acid in an inward open state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9k21 H L 0 A protein NA sodium- and chloride-dependent taurine transporter STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of human taurine transporter TauT bound with homotaurine in an inward-open state Homo sapiens homo sapiens homo sapiens homo sapiens Du, B., Yan, K. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9kvd A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with triple-nAb 3G5, 4H5 and 4C11 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kvd D F 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with triple-nAb 3G5, 4H5 and 4C11 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9kvd E G 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with triple-nAb 3G5, 4H5 and 4C11 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9kve A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with triple-nAb 4H1, 4A5 and 4C1 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9kve E G 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with triple-nAb 4H1, 4A5 and 4C1 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kve D F 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with triple-nAb 4H1, 4A5 and 4C1 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9kvf B A 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 EG.1 spike protein in complex with triple-nAb 4A5, 4C1 and 2E10 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 9kvf F E 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 EG.1 spike protein in complex with triple-nAb 4A5, 4C1 and 2E10 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9kvf C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/20/25 Cryo-EM structure of SARS-CoV-2 EG.1 spike protein in complex with triple-nAb 4A5, 4C1 and 2E10 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Wang, S., Zheng, Z., Li, S., Zheng, Q. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9mi3 B D 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/20/25 Cryo-EM structure of SARS-CoV-2 spike protein in complex with neutralizing human antibody WRAIR-2008 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Thomas, P.V., Joyce, M.G. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9mi3 E F 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/20/25 Cryo-EM structure of SARS-CoV-2 spike protein in complex with neutralizing human antibody WRAIR-2008 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Thomas, P.V., Joyce, M.G. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9mi3 H L 0 K protein NA spike glycoprotein VIRAL PROTEIN 08/20/25 Cryo-EM structure of SARS-CoV-2 spike protein in complex with neutralizing human antibody WRAIR-2008 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Thomas, P.V., Joyce, M.G. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9ml1 H L 0 C protein NA major capsid protein l1 IMMUNE SYSTEM 08/20/25 D24.1M01 Fab bound to HPV16 L1 pentamer Homo sapiens; Human papillomavirus 16 homo sapiens homo sapiens human papillomavirus 16 Hurlburt, N.K., Singh, S., Rodarte, J.V., Pancera, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 9ml1 M N 0 D protein NA major capsid protein l1 IMMUNE SYSTEM 08/20/25 D24.1M01 Fab bound to HPV16 L1 pentamer Homo sapiens; Human papillomavirus 16 homo sapiens homo sapiens human papillomavirus 16 Hurlburt, N.K., Singh, S., Rodarte, J.V., Pancera, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 9ml1 O P 0 E protein NA major capsid protein l1 IMMUNE SYSTEM 08/20/25 D24.1M01 Fab bound to HPV16 L1 pentamer Homo sapiens; Human papillomavirus 16 homo sapiens homo sapiens human papillomavirus 16 Hurlburt, N.K., Singh, S., Rodarte, J.V., Pancera, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 9ml1 Q R 0 A protein NA major capsid protein l1 IMMUNE SYSTEM 08/20/25 D24.1M01 Fab bound to HPV16 L1 pentamer Homo sapiens; Human papillomavirus 16 homo sapiens homo sapiens human papillomavirus 16 Hurlburt, N.K., Singh, S., Rodarte, J.V., Pancera, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 9ml1 S T 0 B protein NA major capsid protein l1 IMMUNE SYSTEM 08/20/25 D24.1M01 Fab bound to HPV16 L1 pentamer Homo sapiens; Human papillomavirus 16 homo sapiens homo sapiens human papillomavirus 16 Hurlburt, N.K., Singh, S., Rodarte, J.V., Pancera, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7fbj B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 7fbj D NA 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 7fbj F NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 7fbj H NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 7fbj J NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 7fbj L NA 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 7fbj N NA 0 M protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 7fbj P NA 0 O protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 2.85 X-RAY DIFFRACTION 0.300 0.254 False True unknown unknown unknown None None None None None 2i26 N NA 0 L protein NA lysozyme c IMMUNE SYSTEM 03/06/07 Crystal structure analysis of the nurse shark new antigen receptor ancestral variable domain in complex with lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.292 0.199 False True unknown unknown unknown None None None None None 2i26 O NA 0 M protein NA lysozyme c IMMUNE SYSTEM 03/06/07 Crystal structure analysis of the nurse shark new antigen receptor ancestral variable domain in complex with lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.292 0.199 False True unknown unknown unknown None None None None None 2i26 P NA 0 Q protein NA lysozyme c IMMUNE SYSTEM 03/06/07 Crystal structure analysis of the nurse shark new antigen receptor ancestral variable domain in complex with lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.292 0.199 False True unknown unknown unknown None None None None None 2i25 N NA 0 L protein NA lysozyme c IMMUNE SYSTEM 03/06/07 Crystal structure analysis of the nurse shark New antigen Receptor PBLA8 variable domain in complex with lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.211 0.185 False True unknown unknown unknown None None None None None 2i25 O NA 0 M protein NA lysozyme c IMMUNE SYSTEM 03/06/07 Crystal structure analysis of the nurse shark New antigen Receptor PBLA8 variable domain in complex with lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.211 0.185 False True unknown unknown unknown None None None None None 9kqc B NA 0 A protein NA hyaluronan synthase TRANSFERASE 05/14/25 Chlorella virus Hyaluronan Synthase bound to VNAR Chiloscyllium plagiosum; Chlorella virus chiloscyllium plagiosum chlorella virus Deng, P., Zhang, X., Xu, M., Wen, J., Li, P., Bi, Y., Wang, H. 3.36 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ht3 A NA 0 NA NA NA NA IMMUNE SYSTEM 07/05/23 Crystal structure of immunoglobulin new antigen receptor variable domain from Okamejei kenojei Okamejei kenojei okamejei kenojei Wen, J., Li, P., Bi, Y. 2.5 X-RAY DIFFRACTION 0.253 0.195 False True unknown unknown unknown None None None None None 8hgi C NA 0 A protein NA gfp FLUORESCENT PROTEIN 09/27/23 Crystal structure of VNAR aGFP14 in complex with GFP Chiloscyllium plagiosum; synthetic construct chiloscyllium plagiosum synthetic construct Zheng, P., Zhu, C., Jin, T. 1.95 X-RAY DIFFRACTION 0.242 0.186 False True unknown unknown unknown None None None None None 8hgi D NA 0 B protein NA gfp FLUORESCENT PROTEIN 09/27/23 Crystal structure of VNAR aGFP14 in complex with GFP Chiloscyllium plagiosum; synthetic construct chiloscyllium plagiosum synthetic construct Zheng, P., Zhu, C., Jin, T. 1.95 X-RAY DIFFRACTION 0.242 0.186 False True unknown unknown unknown None None None None None 7spo C NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/05/22 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with VNAR 3B4 Severe acute respiratory syndrome coronavirus 2; Squalus acanthias squalus acanthias severe acute respiratory syndrome coronavirus2 Shi, K., Aihara, H. 1.92 X-RAY DIFFRACTION 0.226 0.190 False True unknown unknown unknown None None None None None 7spo D NA 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/05/22 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with VNAR 3B4 Severe acute respiratory syndrome coronavirus 2; Squalus acanthias squalus acanthias severe acute respiratory syndrome coronavirus2 Shi, K., Aihara, H. 1.92 X-RAY DIFFRACTION 0.226 0.190 False True unknown unknown unknown None None None None None 7spp C NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/05/22 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with VNAR 2C02 Severe acute respiratory syndrome coronavirus 2; Squalus acanthias squalus acanthias severe acute respiratory syndrome coronavirus2 Shi, K., Aihara, H. 1.96 X-RAY DIFFRACTION 0.224 0.188 False True unknown unknown unknown None None None None None 7s83 B NA 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/23/22 Crystal structure of SARS CoV-2 Spike Receptor Binding Domain in complex with shark neutralizing VNARs ShAb01 and ShAb02 Ginglymostoma cirratum; Severe acute respiratory syndrome coronavirus 2 ginglymostoma cirratum severe acute respiratory syndrome coronavirus2 Chen, W.-H., Hajduczki, A., Dooley, H.M., Joyce, M.G. 2.52 X-RAY DIFFRACTION 0.278 0.233 False True unknown unknown unknown None None None None None 7s83 A NA 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/23/22 Crystal structure of SARS CoV-2 Spike Receptor Binding Domain in complex with shark neutralizing VNARs ShAb01 and ShAb02 Ginglymostoma cirratum; Severe acute respiratory syndrome coronavirus 2 ginglymostoma cirratum severe acute respiratory syndrome coronavirus2 Chen, W.-H., Hajduczki, A., Dooley, H.M., Joyce, M.G. 2.52 X-RAY DIFFRACTION 0.278 0.233 False True unknown unknown unknown None None None None None 7fbk C NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain N501Y mutant in complex with neutralizing nanobody 20G6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 1.9 X-RAY DIFFRACTION 0.239 0.197 False True unknown unknown unknown None None None None None 7fbk D NA 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Crystal structure of SARS-CoV-2 receptor binding domain N501Y mutant in complex with neutralizing nanobody 20G6 Chiloscyllium plagiosum; Severe acute respiratory syndrome coronavirus 2 chiloscyllium plagiosum severe acute respiratory syndrome coronavirus2 Zhu, J., Xu, T., Feng, B., Liu, J. 1.9 X-RAY DIFFRACTION 0.239 0.197 False True unknown unknown unknown None None None None None 6x4g N NA 0 C protein NA icos ligand IMMUNE SYSTEM 10/14/20 Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain Homo sapiens; Orectolobus maculatus orectolobus maculatus homo sapiens Rujas, E., Sicard, T., Julien, J.P. 3.5 X-RAY DIFFRACTION 0.267 0.224 False True unknown unknown unknown None None None None None 5l8j B NA 0 A protein NA aurora kinase a TRANSFERASE 07/20/16 Aurora-A kinase domain in complex with vNAR-D01 S93R Homo sapiens; Orectolobus maculatus orectolobus maculatus homo sapiens Burgess, S.G., Bayliss, R. 1.68 X-RAY DIFFRACTION 0.231 0.199 False True unknown unknown unknown None None None None None 5l8k B NA 0 A protein NA aurora kinase a TRANSFERASE 07/20/16 Aurora-A kinase domain in complex with vNAR-D01 (crystal form 2) Homo sapiens; Orectolobus maculatus orectolobus maculatus homo sapiens Burgess, S.G., Bayliss, R. 1.79 X-RAY DIFFRACTION 0.235 0.190 False True unknown unknown unknown None None None None None 5l8l B NA 0 A protein NA aurora kinase a TRANSFERASE 07/20/16 Aurora-A kinase domain in complex with vNAR-D01 (crystal form 1) Homo sapiens; Orectolobus maculatus orectolobus maculatus homo sapiens Burgess, S.G., Bayliss, R. 1.67 X-RAY DIFFRACTION 0.223 0.191 False True unknown unknown unknown None None None None None 4hgm NA A 0 B protein NA serum albumin IMMUNE SYSTEM 05/08/13 Shark IgNAR Variable Domain Homo sapiens; Squalus acanthias squalus acanthias homo sapiens Olland, A., Kovalenko, O.V., King, D., Svenson, K. 2.34 X-RAY DIFFRACTION 0.259 0.221 False True NA IGKV1 Kappa None None None None None 4hgk C NA 0 B protein NA serum albumin IMMUNE SYSTEM 05/08/13 Shark IgNAR variable domain Homo sapiens; Squalus acanthias squalus acanthias homo sapiens Olland, A.O., Kovalenko, O.V., Svenson, K., King, D. 3.04 X-RAY DIFFRACTION 0.266 0.237 False True unknown unknown unknown None None None None None 4hgk D NA 0 A protein NA serum albumin IMMUNE SYSTEM 05/08/13 Shark IgNAR variable domain Homo sapiens; Squalus acanthias squalus acanthias homo sapiens Olland, A.O., Kovalenko, O.V., Svenson, K., King, D. 3.04 X-RAY DIFFRACTION 0.266 0.237 False True unknown unknown unknown None None None None None 3moq A NA 0 NA NA NA NA NEUROPEPTIDE, IMMUNE SYSTEM 02/16/11 Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks Homo sapiens; Orectolobus maculatus orectolobus maculatus, homo sapiens Streltsov, V.A. 2.054 X-RAY DIFFRACTION 0.249 0.190 False True unknown unknown unknown None None None None None 3moq B NA 0 NA NA NA NA NEUROPEPTIDE, IMMUNE SYSTEM 02/16/11 Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks Homo sapiens; Orectolobus maculatus orectolobus maculatus, homo sapiens Streltsov, V.A. 2.054 X-RAY DIFFRACTION 0.249 0.190 False True unknown unknown unknown None None None None None 3moq C NA 0 NA NA NA NA NEUROPEPTIDE, IMMUNE SYSTEM 02/16/11 Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks Homo sapiens; Orectolobus maculatus orectolobus maculatus, homo sapiens Streltsov, V.A. 2.054 X-RAY DIFFRACTION 0.249 0.190 False True unknown unknown unknown None None None None None 3moq D NA 0 NA NA NA NA NEUROPEPTIDE, IMMUNE SYSTEM 02/16/11 Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks Homo sapiens; Orectolobus maculatus orectolobus maculatus, homo sapiens Streltsov, V.A. 2.054 X-RAY DIFFRACTION 0.249 0.190 False True unknown unknown unknown None None None None None 2z8w C NA 0 B protein NA apical membrane antigen 1 IMMUNE SYSTEM 11/27/07 Structure of an IgNAR-AMA1 complex Orectolobus maculatus; Plasmodium falciparum orectolobus maculatus plasmodium falciparum Streltsov, V.A., Henderson, K.A., Batchelor, A.H., Coley, A.M., Nuttall, S.D. 2.45 X-RAY DIFFRACTION 0.282 0.189 False True unknown unknown unknown None None None None None 2z8w D NA 0 A protein NA apical membrane antigen 1 IMMUNE SYSTEM 11/27/07 Structure of an IgNAR-AMA1 complex Orectolobus maculatus; Plasmodium falciparum orectolobus maculatus plasmodium falciparum Streltsov, V.A., Henderson, K.A., Batchelor, A.H., Coley, A.M., Nuttall, S.D. 2.45 X-RAY DIFFRACTION 0.282 0.189 False True unknown unknown unknown None None None None None 2z8v C NA 0 B protein NA apical membrane antigen 1 IMMUNE SYSTEM 11/27/07 Structure of an IgNAR-AMA1 complex Orectolobus maculatus; Plasmodium falciparum orectolobus maculatus plasmodium falciparum Streltsov, V.A., Henderson, K.A., Batchelor, A.H., Coley, A.M., Nuttall, S.D. 2.35 X-RAY DIFFRACTION 0.285 0.202 False True unknown unknown unknown None None None None None 2z8v D NA 0 A protein NA apical membrane antigen 1 IMMUNE SYSTEM 11/27/07 Structure of an IgNAR-AMA1 complex Orectolobus maculatus; Plasmodium falciparum orectolobus maculatus plasmodium falciparum Streltsov, V.A., Henderson, K.A., Batchelor, A.H., Coley, A.M., Nuttall, S.D. 2.35 X-RAY DIFFRACTION 0.285 0.202 False True unknown unknown unknown None None None None None 2ywz A NA 0 NA NA NA NA IMMUNE SYSTEM 10/30/07 Structure of new antigen receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.21 X-RAY DIFFRACTION 0.254 0.185 False True unknown unknown unknown None None None None None 2ywy A NA 0 NA NA NA NA IMMUNE SYSTEM 10/30/07 Structure of new antigen receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.71 X-RAY DIFFRACTION 0.270 0.180 False True unknown unknown unknown None None None None None 2ywy B NA 0 NA NA NA NA IMMUNE SYSTEM 10/30/07 Structure of new antigen receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.71 X-RAY DIFFRACTION 0.270 0.180 False True unknown unknown unknown None None None None None 2ywy C NA 0 NA NA NA NA IMMUNE SYSTEM 10/30/07 Structure of new antigen receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.71 X-RAY DIFFRACTION 0.270 0.180 False True unknown unknown unknown None None None None None 2ywy D NA 0 NA NA NA NA IMMUNE SYSTEM 10/30/07 Structure of new antigen receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.71 X-RAY DIFFRACTION 0.270 0.180 False True unknown unknown unknown None None None None None 2i27 N NA 0 NA NA NA NA IMMUNE SYSTEM 03/06/07 Crystal Structure Analysis of the Nurse Shark New Antigen Receptor Ancestral variable domain Ginglymostoma cirratum ginglymostoma cirratum Stanfield, R.L., Wilson, I.A. 1.92 X-RAY DIFFRACTION 0.281 0.217 False True unknown unknown unknown None None None None None 2i27 O NA 0 NA NA NA NA IMMUNE SYSTEM 03/06/07 Crystal Structure Analysis of the Nurse Shark New Antigen Receptor Ancestral variable domain Ginglymostoma cirratum ginglymostoma cirratum Stanfield, R.L., Wilson, I.A. 1.92 X-RAY DIFFRACTION 0.281 0.217 False True unknown unknown unknown None None None None None 2coq A NA 0 NA NA NA NA IMMUNE SYSTEM 10/25/05 Structure of new antigen receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A., Carmichael, J.A., Nuttall, S.D. 2.1 X-RAY DIFFRACTION 0.280 0.218 False True unknown unknown unknown None None None None None 1ves A NA 0 NA NA NA NA IMMUNE SYSTEM 08/24/04 Structure of New Antigen Receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.18 X-RAY DIFFRACTION 0.247 0.176 False True unknown unknown unknown None None None None None 1ves B NA 0 NA NA NA NA IMMUNE SYSTEM 08/24/04 Structure of New Antigen Receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.18 X-RAY DIFFRACTION 0.247 0.176 False True unknown unknown unknown None None None None None 1ver A NA 0 NA NA NA NA IMMUNE SYSTEM 08/24/04 Structure of New Antigen Receptor variable domain from sharks Orectolobus maculatus orectolobus maculatus Streltsov, V.A. 2.82 X-RAY DIFFRACTION 0.254 0.166 False True unknown unknown unknown None None None None None 1t6v N NA 0 L protein NA lysozyme c HYDROLASE/IMMUNE SYSTEM 08/24/04 Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Dooley, H., Flajnik, M.F., Wilson, I.A. 1.7 X-RAY DIFFRACTION 0.221 0.194 False True unknown unknown unknown None None None None None 1t6v O NA 0 M protein NA lysozyme c HYDROLASE/IMMUNE SYSTEM 08/24/04 Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Dooley, H., Flajnik, M.F., Wilson, I.A. 1.7 X-RAY DIFFRACTION 0.221 0.194 False True unknown unknown unknown None None None None None 1sq2 N NA 0 L protein NA lysozyme c HYDROLASE/IMMUNE SYSTEM 08/24/04 Crystal Structure Analysis of the Nurse Shark New Antigen Receptor (NAR) Variable Domain in Complex With Lysozyme Gallus gallus; Ginglymostoma cirratum ginglymostoma cirratum gallus gallus Stanfield, R.L., Dooley, H., Flajnik, M.F., Wilson, I.A. 1.45 X-RAY DIFFRACTION 0.225 0.196 False True unknown unknown unknown None None None None None 8ykd S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alpha MEMBRANE PROTEIN 08/13/25 Cryo-EM structure of ADGRG2-Gs complex with NTF nanobody Spodoptera spodoptera spodoptera Huang, S.M., Sheng-chao, G. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ykd N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alpha | guanine nucleotide-binding protein subunit gamma | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/13/25 Cryo-EM structure of ADGRG2-Gs complex with NTF nanobody Spodoptera spodoptera spodoptera | spodoptera | spodoptera Huang, S.M., Sheng-chao, G. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9eje H L 0 A protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1 Fab in complex with N5 NA of A/shorebird/Delaware Bay/309/2016 (DB16, H10N5) -- 3 Fabs Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 4.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9eje I M 0 D protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1 Fab in complex with N5 NA of A/shorebird/Delaware Bay/309/2016 (DB16, H10N5) -- 3 Fabs Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 4.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9eje S T 0 P | G protein | protein NA | NA neuraminidase | neuraminidase VIRAL PROTEIN 08/13/25 NCS.1 Fab in complex with N5 NA of A/shorebird/Delaware Bay/309/2016 (DB16, H10N5) -- 3 Fabs Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Borst, A.J. 4.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9cye H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cye E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cye F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cye G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyf H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Ward, A.B. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyf E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Ward, A.B. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyf F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Ward, A.B. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyf G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Ward, A.B. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyh H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from B/Colorado/06/2017 Homo sapiens; Influenza B virus (B/Colorado/06/2017) homo sapiens homo sapiens influenza b virus (b/colorado/06/2017) Jo, G., Ward, A.B. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyh E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from B/Colorado/06/2017 Homo sapiens; Influenza B virus (B/Colorado/06/2017) homo sapiens homo sapiens influenza b virus (b/colorado/06/2017) Jo, G., Ward, A.B. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyh F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from B/Colorado/06/2017 Homo sapiens; Influenza B virus (B/Colorado/06/2017) homo sapiens homo sapiens influenza b virus (b/colorado/06/2017) Jo, G., Ward, A.B. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyh G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from B/Colorado/06/2017 Homo sapiens; Influenza B virus (B/Colorado/06/2017) homo sapiens homo sapiens influenza b virus (b/colorado/06/2017) Jo, G., Ward, A.B. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cyi H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of 1G01 IgG in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Han, J., Torres, J.L., Ferguson, J.A., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cyi E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of 1G01 IgG in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Han, J., Torres, J.L., Ferguson, J.A., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cyi F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of 1G01 IgG in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Han, J., Torres, J.L., Ferguson, J.A., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cyi G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of 1G01 IgG in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Han, J., Torres, J.L., Ferguson, J.A., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cyj H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of FNI9 IgG in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Jo, G., Han, J., Torres, J.L., Ferguson, J.A., Ward, A.B. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9eit H L 0 A protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1 Fab in complex with N5 NA of A/shorebird/Delaware Bay/309/2016 (DB16, H10N5) -- 4 Fabs Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9eit I M 0 D protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1 Fab in complex with N5 NA of A/shorebird/Delaware Bay/309/2016 (DB16, H10N5) -- 4 Fabs Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9eit N O 0 G protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1 Fab in complex with N5 NA of A/shorebird/Delaware Bay/309/2016 (DB16, H10N5) -- 4 Fabs Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9eit S T 0 P protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1 Fab in complex with N5 NA of A/shorebird/Delaware Bay/309/2016 (DB16, H10N5) -- 4 Fabs Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9ejf H L 0 D protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C4 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.29 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9ejf I M 0 E protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C4 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.29 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9ejf J N 0 F protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C4 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.29 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9ejf O P 0 K protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C4 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.29 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9jft N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of GPR65 complexed with miniGs in pH6.5 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9kfi S s 0 I | T | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of the human relaxin family peptide receptor 3 in complex with relaxin-3 and G protein Escherichia coli; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Chen, Y., Zhou, Q.T., Yan, S.Y., Yan, J.H., Yang, D.H., Chen, J., Wang, M.W. 2.91 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kfj S s 0 I | T | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 3 (RXFP3)-Gi complex Escherichia coli; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Chen, Y., Zhou, Q.T., Yan, S.Y., Yan, J.H., Yang, D.H., Chen, J., Wang, M.W. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kfk S s 0 I | T protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of the relaxin-3-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex Bos taurus; Escherichia coli; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Chen, Y., Zhou, Q.T., Yan, S.Y., Yan, J.H., Yang, D.H., Chen, J., Wang, M.W. 2.95 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kyz A B 0 C | D protein | protein NA | NA protein opg161 | protein opg161 VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 A35 of MPXV in complex with mAb975 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Yan, R.H., Yang, H.N. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mq7 H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 326-366.26 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mq7 I M 0 C protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 326-366.26 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mq7 J N 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 326-366.26 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mq8 H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-33-1_H02 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mq8 I M 0 C protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-33-1_H02 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mq8 J N 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-33-1_H02 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mq9 J N 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 326-289.74 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mq9 H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 326-289.74 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mq9 I M 0 C protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 326-289.74 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mqa H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-7D11 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9mqa I M 0 C protein NA hemagglutinin ha1 chain VIRAL PROTEIN 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-7D11 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9mqa J N 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-7D11 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9mqd H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-12D03 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mqd I M 0 C protein NA hemagglutinin ha1 chain VIRAL PROTEIN 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-12D03 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mqd J N 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN 08/13/25 Cryo-EM structure of hemagglutinin H5N1 in complex with Fab 310-12D03 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Malla, T.N., Tsybovsky, Y., Zhou, T. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mvu D NA 0 A protein NA envelope glycoprotein b ANTIVIRAL PROTEIN 08/13/25 C6 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gB Homo sapiens; Human herpesvirus 1 (strain 17) homo sapiens human herpesvirus 1 (strain 17) Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9mvu E NA 0 C protein NA envelope glycoprotein b ANTIVIRAL PROTEIN 08/13/25 C6 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gB Homo sapiens; Human herpesvirus 1 (strain 17) homo sapiens human herpesvirus 1 (strain 17) Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9mvu F NA 0 B protein NA envelope glycoprotein b ANTIVIRAL PROTEIN 08/13/25 C6 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gB Homo sapiens; Human herpesvirus 1 (strain 17) homo sapiens human herpesvirus 1 (strain 17) Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9mw5 D NA 0 A protein NA envelope glycoprotein b ANTIVIRAL PROTEIN 08/13/25 D1 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gB Homo sapiens homo sapiens homo sapiens Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9mw5 E NA 0 B protein NA envelope glycoprotein b ANTIVIRAL PROTEIN 08/13/25 D1 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gB Homo sapiens homo sapiens homo sapiens Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9mw5 F NA 0 C protein NA envelope glycoprotein b ANTIVIRAL PROTEIN 08/13/25 D1 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gB Homo sapiens homo sapiens homo sapiens Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9my8 H L 0 NA NA NA NA ANTIVIRAL PROTEIN 08/13/25 D7 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gD Homo sapiens; Human herpesvirus 2; Lama glama lama glama lama glama Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9my8 A NA 0 B protein NA glycoprotein d ANTIVIRAL PROTEIN 08/13/25 D7 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gD Homo sapiens; Human herpesvirus 2; Lama glama homo sapiens human herpesvirus 2 Viadiu, H., Abernathy, E., Lee, C.V., Hung, M., Yu, Y., Xing, W., Yu, X. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9o4n H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12042 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o4n E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12042 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o4n F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12042 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o4n G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12042 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o4o H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12044 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.53 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9o4o E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12044 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.53 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9o4o F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12044 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.53 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9o4o G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of CR12044 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.53 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9o4p E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of AF9C-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9o4p F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of AF9C-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9o4p G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of AF9C-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9o4p H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of AF9C-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9o4q E I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of Z1A11-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o4q F J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of Z1A11-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o4q G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of Z1A11-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o4q H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/25 Cryo-EM structure of Z1A11-GL Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1) Homo sapiens; Influenza A virus (A/California/07/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Jo, G., Ward, A.B. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9o9v H L 0 D protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C1 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9o9v I M 0 E protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C1 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9o9v J N 0 F protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C1 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9o9v O P 0 K protein NA neuraminidase VIRAL PROTEIN 08/13/25 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C1 Reconstruction] Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Borst, A.J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9q8l H L 0 A protein NA programmed cell death protein 1 IMMUNE SYSTEM 08/13/25 Crystal Structure of 21A08Ap1-Fab in Complex with Human PD-1 at 1.85 angstrom Resolution Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Murer, P., Petersen, L., Egli, N., Salazar, U., Neubert, P., Zurbach, A., Rau, A., Stocker, C., Katopodis, A., Huber, C., Carr, K., Arduin, A. 1.85 X-RAY DIFFRACTION 0.216 0.178 False True IGHV3 IGLV1 Lambda None None None None None 9k3k S s 0 A | G protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 4 (MC4R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | bos taurus Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 3.12 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k3k N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 4 (MC4R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens, synthetic construct Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9k3l S s 0 A protein NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 2 (MC2R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 3.01 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k3l N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 2 (MC2R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens, synthetic construct Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9k3p S s 0 A protein NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k3p N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens, synthetic construct Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9mgb A a 0 Q | D protein | protein NA | NA r-phycoerythrin beta chain | r-phycoerythrin beta chain IMMUNE SYSTEM 08/06/25 scFv antibody CL33 bound to R-phycoerythrin Mus musculus; Neopyropia tenera neopyropia tenera mus musculus neopyropia tenera | neopyropia tenera Rashleigh, L., Gully, B.S. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mgb C c 0 F | B protein | protein NA | NA r-phycoerythrin alpha chain | r-phycoerythrin beta chain IMMUNE SYSTEM 08/06/25 scFv antibody CL33 bound to R-phycoerythrin Mus musculus; Neopyropia tenera neopyropia tenera mus musculus neopyropia tenera | neopyropia tenera Rashleigh, L., Gully, B.S. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mgb E e 0 O protein NA r-phycoerythrin alpha chain IMMUNE SYSTEM 08/06/25 scFv antibody CL33 bound to R-phycoerythrin Mus musculus; Neopyropia tenera mus musculus neopyropia tenera Rashleigh, L., Gully, B.S. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mgb G g 0 F protein NA r-phycoerythrin alpha chain IMMUNE SYSTEM 08/06/25 scFv antibody CL33 bound to R-phycoerythrin Mus musculus; Neopyropia tenera neopyropia tenera mus musculus neopyropia tenera Rashleigh, L., Gully, B.S. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mgb I i 0 M | J protein | protein NA | NA r-phycoerythrin beta chain | r-phycoerythrin beta chain IMMUNE SYSTEM 08/06/25 scFv antibody CL33 bound to R-phycoerythrin Mus musculus; Neopyropia tenera neopyropia tenera mus musculus neopyropia tenera | neopyropia tenera Rashleigh, L., Gully, B.S. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mgb K k 0 L protein NA r-phycoerythrin alpha chain IMMUNE SYSTEM 08/06/25 scFv antibody CL33 bound to R-phycoerythrin Mus musculus; Neopyropia tenera mus musculus neopyropia tenera Rashleigh, L., Gully, B.S. 2.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8y72 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/06/25 positive allosteric modulator(BMS986122)-bound mu-opioid receptor-Gi complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Luo, P., Xu, Y., Wang, Y., Zhuang, Y., Xu, H.E. 2.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9bqw H L 0 A protein NA decorin-binding protein a IMMUNE SYSTEM 08/06/25 Fab F945-DbpA complex Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 2.55 X-RAY DIFFRACTION 0.246 0.202 False True IGHV3 IGKV1 Kappa None None None None None 9gcn D NA 0 Z protein NA alpha-cobratoxin TOXIN 08/06/25 Co-crystal VHH (TPL1158_01_C09) - alpha-cobratoxin (Naja kaouthia) Naja kaouthia; Vicugna pacos vicugna pacos naja kaouthia Rivera-de-Torre, E., Burlet, N.J., Laustsen, A.H., Morth, J.P. 3 X-RAY DIFFRACTION 0.292 0.238 False True IGHV1 NA NA None None None None None 9gcn A NA 0 X protein NA alpha-cobratoxin TOXIN 08/06/25 Co-crystal VHH (TPL1158_01_C09) - alpha-cobratoxin (Naja kaouthia) Naja kaouthia; Vicugna pacos vicugna pacos naja kaouthia Rivera-de-Torre, E., Burlet, N.J., Laustsen, A.H., Morth, J.P. 3 X-RAY DIFFRACTION 0.292 0.238 False True IGHV1 NA NA None None None None None 9gcn B NA 0 Y protein NA alpha-cobratoxin TOXIN 08/06/25 Co-crystal VHH (TPL1158_01_C09) - alpha-cobratoxin (Naja kaouthia) Naja kaouthia; Vicugna pacos vicugna pacos naja kaouthia Rivera-de-Torre, E., Burlet, N.J., Laustsen, A.H., Morth, J.P. 3 X-RAY DIFFRACTION 0.292 0.238 False True IGHV1 NA NA None None None None None 9gcn C NA 0 V protein NA alpha-cobratoxin TOXIN 08/06/25 Co-crystal VHH (TPL1158_01_C09) - alpha-cobratoxin (Naja kaouthia) Naja kaouthia; Vicugna pacos vicugna pacos naja kaouthia Rivera-de-Torre, E., Burlet, N.J., Laustsen, A.H., Morth, J.P. 3 X-RAY DIFFRACTION 0.292 0.238 False True IGHV1 NA NA None None None None None 9j05 B C 0 A protein NA p2y purinoceptor 14,soluble cytochrome b562 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/06/25 Apo state purinergic receptor P2Y14-BRIL/PPTN/1B3 Fab-4/9Glue Escherichia coli; Homo sapiens homo sapiens homo sapiens homo sapiens, escherichia coli Wang, T.X., Tang, W.Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9k3f S s 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 3 (MC3R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | bos taurus | homo sapiens, synthetic construct Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 2.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k3h S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit MEMBRANE PROTEIN 08/06/25 Cryo-EM structure of the unliganded human melanocortin receptor 5 (MC5R)-Gs complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens, synthetic construct Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W. 2.86 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9cu7 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 07/30/25 Structure of 16.ND.92 Fab in complex with A/Solomon Islands/3/2006(H1N1) influenza virus Hemagglutinin Homo sapiens; Influenza A virus (A/Solomon Islands/3/2006(H1N1)) homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) | influenza a virus (a/solomonislands/3/2006(h1n1)) Ouyang, W.O., Pholcharee, T., Wu, N.C. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cu7 I M 0 D | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 07/30/25 Structure of 16.ND.92 Fab in complex with A/Solomon Islands/3/2006(H1N1) influenza virus Hemagglutinin Homo sapiens; Influenza A virus (A/Solomon Islands/3/2006(H1N1)) homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) | influenza a virus (a/solomonislands/3/2006(h1n1)) Ouyang, W.O., Pholcharee, T., Wu, N.C. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cu7 J N 0 F | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 07/30/25 Structure of 16.ND.92 Fab in complex with A/Solomon Islands/3/2006(H1N1) influenza virus Hemagglutinin Homo sapiens; Influenza A virus (A/Solomon Islands/3/2006(H1N1)) homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) | influenza a virus (a/solomonislands/3/2006(h1n1)) Ouyang, W.O., Pholcharee, T., Wu, N.C. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9u8g E NA 0 B protein NA transmembrane protease serine 2 catalytic chain IMMUNE SYSTEM 07/30/25 Crystal structure of TMPRSS2 in complex with nanobody77_10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Duan, Y., Zhao, Z., Liu, X., Wang, H., Yang, H. 2 X-RAY DIFFRACTION 0.230 0.193 False True IGHV3 NA NA None None None None None 9u8g F NA 0 D protein NA transmembrane protease serine 2 catalytic chain IMMUNE SYSTEM 07/30/25 Crystal structure of TMPRSS2 in complex with nanobody77_10 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Duan, Y., Zhao, Z., Liu, X., Wang, H., Yang, H. 2 X-RAY DIFFRACTION 0.230 0.193 False True IGHV3 NA NA None None None None None 9dn2 H L 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 07/30/25 TJ5-1 Fab in complex with NG2 COBRA hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Nagashima, K., Mousa, J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9dn2 I M 0 B protein NA hemagglutinin VIRAL PROTEIN/Immune System 07/30/25 TJ5-1 Fab in complex with NG2 COBRA hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Nagashima, K., Mousa, J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9dn2 J N 0 C protein NA hemagglutinin VIRAL PROTEIN/Immune System 07/30/25 TJ5-1 Fab in complex with NG2 COBRA hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Nagashima, K., Mousa, J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9do2 H L 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 07/30/25 #1664 Fab in complex with NG2 COBRA hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Nagashima, K., Mousa, J. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV4 Lambda None None None None None 9e21 H L 0 S protein NA sars xbb.1.5 spike IMMUNE SYSTEM 07/30/25 CryoEM structure of a broadly neutralizing anti-SARS-CoV-2 antibody 52 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jaiswal, D., Bajic, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9e7n C NA 0 A protein NA gametocyte surface protein p230 PROTEIN BINDING 07/30/25 Pfs230 D13D14 in complex with nanobody W2809 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Tan, L.L., Dietrich, M.H., Tham, W.H. 2.49 X-RAY DIFFRACTION 0.264 0.224 False True IGHV1 NA NA None None None None None 9e7n D NA 0 B protein NA gametocyte surface protein p230 PROTEIN BINDING 07/30/25 Pfs230 D13D14 in complex with nanobody W2809 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Tan, L.L., Dietrich, M.H., Tham, W.H. 2.49 X-RAY DIFFRACTION 0.264 0.224 False True IGHV1 NA NA None None None None None 9e7o A NA 0 B protein NA gametocyte surface protein p230 PROTEIN BINDING 07/30/25 Pfs230 D13D14 in complex with nanobody W2810 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Dietrich, M.H., Tan, L.L., Tham, W.H. 1.93 X-RAY DIFFRACTION 0.254 0.214 False True IGHV1 NA NA None None None None None 9e7p A NA 0 B protein NA gametocyte surface protein p230 PROTEIN BINDING 07/30/25 Pfs230 D13D14 in complex with nanobody W2812 Plasmodium falciparum 3D7; Vicugna pacos vicugna pacos plasmodium falciparum 3d7 Dietrich, M.H., Tan, L.L., Tham, W.H. 3.22 X-RAY DIFFRACTION 0.320 0.286 False True IGHV1 NA NA None None None None None 9g4e C D 0 A | B protein | protein NA | NA peptide antibiotic transporter sbma | peptide antibiotic transporter sbma TRANSPORT PROTEIN 07/30/25 CryoEM structure of the proton-dependent antibacterial peptide transporter SbmA in complex with FabS11-1 in lipid nanodiscs at pH 5.5, inward-open state Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli | escherichia coli Ghilarov, D., Beis, K. 3.44 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV4 Kappa None None None None None 9g4f C D 0 A | B protein | protein NA | NA peptide antibiotic transporter sbma | peptide antibiotic transporter sbma TRANSPORT PROTEIN 07/30/25 CryoEM structure of the proton-dependent antibacterial peptide transporter SbmA in complex with FabS11-1 in lipid nanodiscs at pH 5.5, inward-closed state Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli | escherichia coli Ghilarov, D., Beis, K. 3.58 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV4 Kappa None None None None None 9iv6 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/30/25 Cryo-EM structure of hGPR4-Gs complex in pH7.0 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhong, Y.N., Guo, L.L. 2.71 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9iw2 H L 0 P | F protein | protein NA | NA togavirin | chikv e1 ANTIVIRAL PROTEIN 07/30/25 Chikungunya virus E protein complexed with C37 Fab Chikungunya virus; Homo sapiens homo sapiens homo sapiens chikungunya virus | chikungunya virus Qi, J., Han, X., Wang, F., Tian, S., Gao, F.G., Yan, J. 3.2 X-RAY DIFFRACTION 0.277 0.222 False True IGHV4 IGKV3 Kappa None None None None None 9ixj N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/30/25 histamine-bound H2R in complex with Gs Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Chen, K. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jcy C B 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 07/30/25 Crystal structure of the HCoV-HKU1 RBD in complex with Fab Homo sapiens; Human coronavirus HKU1 (isolate N1) homo sapiens homo sapiens human coronavirus hku1 (isolate n1) Wang, H., Zhao, Z., Liu, X., Duan, Y., Yang, H. 1.8 X-RAY DIFFRACTION 0.203 0.173 False True IGHV4 IGKV1 Kappa None None None None None 9jd0 F NA 0 D protein NA transmembrane protease serine 2 catalytic chain ANTIVIRAL PROTEIN 07/30/25 Crystal structure of TMPRSS2 in complex with nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Wang, H., Zhao, Z., Liu, X., Duan, Y., Yang, H. 2 X-RAY DIFFRACTION 0.221 0.188 False True IGHV3 NA NA None None None None None 9jd0 E NA 0 C protein NA transmembrane protease serine 2 catalytic chain ANTIVIRAL PROTEIN 07/30/25 Crystal structure of TMPRSS2 in complex with nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Wang, H., Zhao, Z., Liu, X., Duan, Y., Yang, H. 2 X-RAY DIFFRACTION 0.221 0.188 False True IGHV3 NA NA None None None None None 9jd1 B A 0 D protein NA transmembrane protease serine 2 catalytic chain ANTIVIRAL PROTEIN 07/30/25 Crystal structure of TMPRSS2 in complex with Fab Homo sapiens homo sapiens homo sapiens homo sapiens Wang, H., Liu, X., Zhao, Z., Duan, Y., Yang, H. 1.9 X-RAY DIFFRACTION 0.223 0.190 False True IGHV3 IGLV6 Lambda None None None None None 9mla G J 0 A protein NA surface protein VIRAL PROTEIN 07/30/25 Pre-fusion HERV-K Envelope Protein Trimer Ectodomain in complex with Kenv-6 Fab Enterobacteria phage T4; Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Shek, J., Sun, C., Hastie, K., Saphire, E.O. 2.24 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV3 Kappa None None None None None 9mla H K 0 B protein NA surface protein VIRAL PROTEIN 07/30/25 Pre-fusion HERV-K Envelope Protein Trimer Ectodomain in complex with Kenv-6 Fab Enterobacteria phage T4; Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Shek, J., Sun, C., Hastie, K., Saphire, E.O. 2.24 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV3 Kappa None None None None None 9mla I L 0 C protein NA surface protein VIRAL PROTEIN 07/30/25 Pre-fusion HERV-K Envelope Protein Trimer Ectodomain in complex with Kenv-6 Fab Enterobacteria phage T4; Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Shek, J., Sun, C., Hastie, K., Saphire, E.O. 2.24 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV3 Kappa None None None None None 9mlk H L 0 C protein NA transmembrane protein VIRAL PROTEIN 07/30/25 Post-fusion HERV-K Envelope Protein in complex with Kenv-4 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Sun, C., Shek, J., Hastie, K., Saphire, E.O. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9mlk I M 0 B protein NA transmembrane protein VIRAL PROTEIN 07/30/25 Post-fusion HERV-K Envelope Protein in complex with Kenv-4 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Sun, C., Shek, J., Hastie, K., Saphire, E.O. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9mlk J N 0 A protein NA transmembrane protein VIRAL PROTEIN 07/30/25 Post-fusion HERV-K Envelope Protein in complex with Kenv-4 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Sun, C., Shek, J., Hastie, K., Saphire, E.O. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 9mpb H L 0 NA NA NA NA IMMUNE SYSTEM 07/30/25 Crystal structure of the HIV V2-apex-targeting antibody RM038, derived from macaque ApexGT6 immunization Macaca macaca macaca Agrawal, S., Wilson, I.A. 1.98 X-RAY DIFFRACTION 0.221 0.186 False True IGHV3 IGKV2 Kappa None None None None None 9mpc H L 0 NA NA NA NA IMMUNE SYSTEM 07/30/25 Crystal structure of the HIV V2-apex-targeting antibody RM018 from macaque Macaca macaca macaca Agrawal, S., Wilson, I.A. 3.3 X-RAY DIFFRACTION 0.307 0.249 False True IGHV1 IGLV2 Lambda None None None None None 9njy H L 0 A protein NA clumping factor a IMMUNE SYSTEM 07/30/25 Terminal two domains of ClfA002 with bound Fab of AZD7745 Mammalia; Staphylococcus aureus mammalia mammalia staphylococcus aureus Oganesyan, V.Y. 1.58 X-RAY DIFFRACTION 0.219 0.199 False True IGHV4 IGKV1 Kappa None None None None None 9ore H L 0 A | B protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 IMMUNE SYSTEM 07/30/25 CryoEM structure of 4F11 Fab bound to stabilized MPV-2c HMPV preF Homo sapiens; human metapneumovirus homo sapiens homo sapiens human metapneumovirus | human metapneumovirus McGovern, M.R., Pancera, M. 4.13 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV2 Kappa None None None None None 9s37 B NA 0 D protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 07/30/25 Structure of LGR4 with NB21 Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 3.94 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9s37 A NA 0 D protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 07/30/25 Structure of LGR4 with NB21 Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9dmf H L 0 NA NA NA NA IMMUNE SYSTEM 07/23/25 Crystal structure of LJF-0085 Fab, a non-human primate antibody targets HIV-1 envelope protein Macaca mulatta macaca mulatta macaca mulatta Lin, X., Wilson, I.A. 1.48 X-RAY DIFFRACTION 0.200 0.188 False True IGHV4 IGKV1 Kappa None None None None None 9g3d C NA 0 B protein NA peptide antibiotic transporter sbma TRANSPORT PROTEIN 07/23/25 Cryo-EM structure of SbmA in the inward-facing-narrow conformation bound to 2 sybodies Escherichia coli; synthetic construct synthetic construct escherichia coli Thangaratnarajah, C., Ettema, T.W., Slotboom, D.J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9g3d D NA 0 A protein NA peptide antibiotic transporter sbma TRANSPORT PROTEIN 07/23/25 Cryo-EM structure of SbmA in the inward-facing-narrow conformation bound to 2 sybodies Escherichia coli; synthetic construct synthetic construct escherichia coli Thangaratnarajah, C., Ettema, T.W., Slotboom, D.J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9g3e C NA 0 A protein NA peptide antibiotic transporter sbma TRANSPORT PROTEIN 07/23/25 Cryo-EM structure of SbmA in the inward-facing-wide conformation bound to 2 sybodies Escherichia coli; synthetic construct synthetic construct escherichia coli Thangaratnarajah, C., Ettema, T.W., Slotboom, D.J. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9g3e D NA 0 B protein NA peptide antibiotic transporter sbma TRANSPORT PROTEIN 07/23/25 Cryo-EM structure of SbmA in the inward-facing-wide conformation bound to 2 sybodies Escherichia coli; synthetic construct synthetic construct escherichia coli Thangaratnarajah, C., Ettema, T.W., Slotboom, D.J. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9h6u H L 0 A protein NA spike glycoprotein,fibritin PROTEIN BINDING 07/23/25 SARS-CoV-2 S protein in complex with pT1679 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Hansen, G., Benecke, T., Vollmer, B., Gruenewald, K., Krey, T. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9jie C D 0 B protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab C6 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9jie H L 0 A protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab C6 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9jif H L 0 A protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Hepatitis E virus capsid protein E2s domain (genotype I) in complex with Fab C6 Hepatitis E virus genotype 1 (isolate Human/Burma); Homo sapiens homo sapiens homo sapiens hepatitis e virus genotype 1 (isolatehuman/burma) Liu, L., Zheng, Q., Li, S. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9jif C D 0 B protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Hepatitis E virus capsid protein E2s domain (genotype I) in complex with Fab C6 Hepatitis E virus genotype 1 (isolate Human/Burma); Homo sapiens homo sapiens homo sapiens hepatitis e virus genotype 1 (isolatehuman/burma) Liu, L., Zheng, Q., Li, S. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 9jij H L 0 A protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Hepatitis E virus capsid protein E2s domain (genotype I) in complex with Fab C158 Hepatitis E virus genotype 1 (isolate Human/Burma); Homo sapiens homo sapiens homo sapiens hepatitis e virus genotype 1 (isolatehuman/burma) Liu, L., Zheng, Q., Li, S. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9jij E F 0 B protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Hepatitis E virus capsid protein E2s domain (genotype I) in complex with Fab C158 Hepatitis E virus genotype 1 (isolate Human/Burma); Homo sapiens homo sapiens homo sapiens hepatitis e virus genotype 1 (isolatehuman/burma) Liu, L., Zheng, Q., Li, S. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9jik H L 0 A protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab C127 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9jik C D 0 B protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab C127 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9jim H L 0 A protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab C145 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9jim C D 0 B protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab C145 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9jin C D 0 B protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab H4 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9jin H L 0 A protein NA pro-secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Rat hepatitis E virus capsid protein E2s domain in complex with Fab H4 Homo sapiens; Rocahepevirus ratti homo sapiens homo sapiens rocahepevirus ratti Liu, L., Zheng, Q., Li, S. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9jio H L 0 B protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Hepatitis E virus capsid protein E2s domain (genotype I) in complex with Fab H4 Hepatitis E virus genotype 1 (isolate Human/Burma); Homo sapiens homo sapiens homo sapiens hepatitis e virus genotype 1 (isolatehuman/burma) Liu, L., Zheng, Q., Li, S. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9jio E F 0 A protein NA secreted protein orf2 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 Hepatitis E virus capsid protein E2s domain (genotype I) in complex with Fab H4 Hepatitis E virus genotype 1 (isolate Human/Burma); Homo sapiens homo sapiens homo sapiens hepatitis e virus genotype 1 (isolatehuman/burma) Liu, L., Zheng, Q., Li, S. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9lvb H L 0 A protein NA auxin transporter protein 1,soluble cytochrome b562 PROTEIN TRANSPORT/IMMUNE SYSTEM 07/23/25 IAA-free AUX1 Arabidopsis thaliana; Escherichia coli; Homo sapiens; Lama glama homo sapiens homo sapiens arabidopsis thaliana, escherichia coli Jing, D., Kong, F., Wang, C.C., Shi, Y.G., Huang, G.X.Y. 3.97 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9lvb N NA 0 NA NA NA NA PROTEIN TRANSPORT/IMMUNE SYSTEM 07/23/25 IAA-free AUX1 Arabidopsis thaliana; Escherichia coli; Homo sapiens; Lama glama lama glama Jing, D., Kong, F., Wang, C.C., Shi, Y.G., Huang, G.X.Y. 3.97 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9m0r S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/23/25 Structure of neuropeptide FF receptor 1 complex with NPVF Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Pan, B.X., Jiang, Y., Li, X.Z. 2.47 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9m1o S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/23/25 Cryo-EM structures of NPFFR2 complex with neuropeptide FF Bos taurus; Escherichia coli; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Pan, B.X., Li, X.Z., Jiang, Y. 2.49 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9m2f S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/23/25 Structure of neuropeptide FF receptor 1 complex with NPFF Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Pan, B.X., Jiang, Y., Li, X.Z. 2.93 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9m54 S s 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/23/25 Cryo-EM structure of neuropeptide FF receptor 2 complex with NPVF Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus bos taurus | bos taurus | rattus norvegicus Pan, B.X., Jiang, Y., Li, X.Z. 3.24 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mew E D 0 B protein NA junv gp1 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 JUNV GP1, GP2, SSP and CR1-28 Fab complex in a pseudotyped virus membrane Homo sapiens; Mammarenavirus juninense homo sapiens homo sapiens mammarenavirus juninense Taylor, L.J., Sawaya, M.R., Castells-Graells, R., Rodriguez, J.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9mew J I 0 G protein NA junv gp1 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 JUNV GP1, GP2, SSP and CR1-28 Fab complex in a pseudotyped virus membrane Homo sapiens; Mammarenavirus juninense homo sapiens homo sapiens mammarenavirus juninense Taylor, L.J., Sawaya, M.R., Castells-Graells, R., Rodriguez, J.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9mew O N 0 L protein NA junv gp1 VIRAL PROTEIN/IMMUNE SYSTEM 07/23/25 JUNV GP1, GP2, SSP and CR1-28 Fab complex in a pseudotyped virus membrane Homo sapiens; Mammarenavirus juninense homo sapiens homo sapiens mammarenavirus juninense Taylor, L.J., Sawaya, M.R., Castells-Graells, R., Rodriguez, J.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9mqv H L 0 A protein NA neuraminidase VIRAL PROTEIN, HYDROLASE/IMMUNE SYSTEM 07/23/25 Crystal structure of human 1122A11 Fab in complex with influenza virus neuraminidase from A/Singapore/INFIMH-16-0019/2016 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.204 0.169 False True IGHV1 IGLV3 Lambda None None None None None 9n0d E D 0 B protein NA pre-glycoprotein polyprotein gp complex VIRAL PROTEIN 07/23/25 JUNV GP1, GP2, SSP complex with neutralizing antibody in a pseudotyped virus membrane Mammarenavirus juninense; Mus musculus mus musculus mus musculus mammarenavirus juninense Taylor, L.J., Sawaya, M.R., Castells-Graells, R., Rodriguez, J.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9n0d J I 0 G protein NA pre-glycoprotein polyprotein gp complex VIRAL PROTEIN 07/23/25 JUNV GP1, GP2, SSP complex with neutralizing antibody in a pseudotyped virus membrane Mammarenavirus juninense; Mus musculus mus musculus mus musculus mammarenavirus juninense Taylor, L.J., Sawaya, M.R., Castells-Graells, R., Rodriguez, J.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9n0d O N 0 L protein NA pre-glycoprotein polyprotein gp complex VIRAL PROTEIN 07/23/25 JUNV GP1, GP2, SSP complex with neutralizing antibody in a pseudotyped virus membrane Mammarenavirus juninense; Mus musculus mus musculus mus musculus mammarenavirus juninense Taylor, L.J., Sawaya, M.R., Castells-Graells, R., Rodriguez, J.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9nab D C 0 A protein NA integrin beta-1 IMMUNE SYSTEM 07/23/25 Cryo-EM structure of the alpha5beta1 integrin headpiece with OS2966 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Wang, L., Zhang, C. 2.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 9pat G I 0 A protein NA 6-deoxyerythronolide-b synthase Transferase/Immune System 07/23/25 Antibody (1B2) Bound Rifamycin Synthetase Module 1 in the Transacylation Mode Amycolatopsis mediterranei; Homo sapiens homo sapiens homo sapiens amycolatopsis mediterranei Cogan, D.P., Liu, C., West, R.C., Chen, M. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9pat H L 0 B protein NA 6-deoxyerythronolide-b synthase Transferase/Immune System 07/23/25 Antibody (1B2) Bound Rifamycin Synthetase Module 1 in the Transacylation Mode Amycolatopsis mediterranei; Homo sapiens homo sapiens homo sapiens amycolatopsis mediterranei Cogan, D.P., Liu, C., West, R.C., Chen, M. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9pav H L 0 B protein NA 6-deoxyerythronolide-b synthase Transferase/Immune System 07/23/25 Antibody (1B2) Bound Rifamycin Synthetase Module 1 in the Elongation Mode Amycolatopsis mediterranei; Homo sapiens homo sapiens homo sapiens amycolatopsis mediterranei Cogan, D.P., Liu, C., West, R.C., Chen, M. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9pav G I 0 A protein NA 6-deoxyerythronolide-b synthase Transferase/Immune System 07/23/25 Antibody (1B2) Bound Rifamycin Synthetase Module 1 in the Elongation Mode Amycolatopsis mediterranei; Homo sapiens homo sapiens homo sapiens amycolatopsis mediterranei Cogan, D.P., Liu, C., West, R.C., Chen, M. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9ei9 A D 0 C protein NA hemagglutinin ha1 IMMUNE SYSTEM 07/16/25 Cryo-EM structure of 5E10 Fab in complex with H3 influenza Victoria 2011 HA trimer Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Gorman, J., Kwong, P.D. 3.89 ELECTRON MICROSCOPY NA NA False True IGHV8 IGLV2 Lambda None None None None None 9ei9 H J 0 B | F | E protein | protein | protein NA | NA | NA hemagglutinin ha1 | hemagglutinin ha2 | hemagglutinin ha2 IMMUNE SYSTEM 07/16/25 Cryo-EM structure of 5E10 Fab in complex with H3 influenza Victoria 2011 HA trimer Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus | influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.89 ELECTRON MICROSCOPY NA NA False True IGHV8 IGLV2 Lambda None None None None None 8z9o N NA 0 C | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/16/25 Cryo-EM structure of human GPR4-Gs complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | rattus norvegicus Chen, L.N., Mao, C.Y., Cheng, S.Z., Liu, Y.F., Fu, Y.F., Ma, X.Y., Xu, P., Ji, S.Y., Wang, W.W., Shen, D.D., Zhang, H.B., Shen, Q.Y., Chai, R., Zhang, M., Yang, L., Han, F., Mao, C.Y., Cai, X.J., Zhang, Y. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9e69 H L 0 NA NA NA NA IMMUNE SYSTEM 07/16/25 Antibody 5E10 Homo sapiens homo sapiens homo sapiens Zhou, T., Sao-Fong Cheung, C., Kwong, P.D. 2.63 X-RAY DIFFRACTION 0.242 0.218 False True IGHV8 IGLV2 Lambda None None None None None 9e69 A B 0 NA NA NA NA IMMUNE SYSTEM 07/16/25 Antibody 5E10 Homo sapiens homo sapiens homo sapiens Zhou, T., Sao-Fong Cheung, C., Kwong, P.D. 2.63 X-RAY DIFFRACTION 0.242 0.218 False True IGHV8 IGLV2 Lambda None None None None None 9fys B C 0 X protein NA alpha-bungarotoxin TOXIN 07/16/25 D11 mAbs bound to alpha-Bungarotoxin Bungarus multicinctus; Homo sapiens homo sapiens homo sapiens bungarus multicinctus Wade, J., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.32 X-RAY DIFFRACTION 0.192 0.167 False True IGHV1 IGLV6 Lambda None None None None None 9fys I M 0 Z protein NA alpha-bungarotoxin TOXIN 07/16/25 D11 mAbs bound to alpha-Bungarotoxin Bungarus multicinctus; Homo sapiens homo sapiens homo sapiens bungarus multicinctus Wade, J., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.32 X-RAY DIFFRACTION 0.192 0.167 False True IGHV1 IGLV6 Lambda None None None None None 9fyt I M 0 B protein NA alpha-cobratoxin TOXIN 07/16/25 mAbs in complex with cobratoxin at pH 4.5 Homo sapiens; Naja kaouthia homo sapiens homo sapiens naja kaouthia Wade, J., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.55 X-RAY DIFFRACTION 0.237 0.186 False True IGHV1 IGLV3 Lambda None None None None None 9fyt C D 0 A protein NA alpha-cobratoxin TOXIN 07/16/25 mAbs in complex with cobratoxin at pH 4.5 Homo sapiens; Naja kaouthia homo sapiens homo sapiens naja kaouthia Wade, J., Bohn, M.F., Laustsen, A.H., Morth, J.P. 1.55 X-RAY DIFFRACTION 0.237 0.186 False True IGHV1 IGLV3 Lambda None None None None None 9h39 C NA 0 A protein NA lysm type receptor kinase PLANT PROTEIN 07/16/25 Crystal structure of Lotus japonicus CHIP13 extracellular domain in complex with a nanobody Lama glama; Lotus japonicus lama glama lotus japonicus Gysel, K., Andersen, K.R. 1.66 X-RAY DIFFRACTION 0.225 0.182 False True IGHV1 NA NA None None None None None 9h39 D NA 0 B protein NA lysm type receptor kinase PLANT PROTEIN 07/16/25 Crystal structure of Lotus japonicus CHIP13 extracellular domain in complex with a nanobody Lama glama; Lotus japonicus lama glama lotus japonicus Gysel, K., Andersen, K.R. 1.66 X-RAY DIFFRACTION 0.225 0.182 False True IGHV1 NA NA None None None None None 9h6v E NA 0 B protein NA lysm type receptor kinase PLANT PROTEIN 07/16/25 Lotus japonicus CERK6 extracellular domain in complex with two nanobodies Lama glama; Lotus japonicus lama glama lotus japonicus Gysel, K., Alsarraf, H.M.A.B., Hansen, S.B., Andersen, K.R. 2.19 X-RAY DIFFRACTION 0.252 0.204 False True IGHV1 NA NA None None None None None 9h6v F NA 0 A protein NA lysm type receptor kinase PLANT PROTEIN 07/16/25 Lotus japonicus CERK6 extracellular domain in complex with two nanobodies Lama glama; Lotus japonicus lama glama lotus japonicus Gysel, K., Alsarraf, H.M.A.B., Hansen, S.B., Andersen, K.R. 2.19 X-RAY DIFFRACTION 0.252 0.204 False True IGHV1 NA NA None None None None None 9h6v D NA 0 B protein NA lysm type receptor kinase PLANT PROTEIN 07/16/25 Lotus japonicus CERK6 extracellular domain in complex with two nanobodies Lama glama; Lotus japonicus lama glama lotus japonicus Gysel, K., Alsarraf, H.M.A.B., Hansen, S.B., Andersen, K.R. 2.19 X-RAY DIFFRACTION 0.252 0.204 False True IGHV1 NA NA None None None None None 9h6v C NA 0 A protein NA lysm type receptor kinase PLANT PROTEIN 07/16/25 Lotus japonicus CERK6 extracellular domain in complex with two nanobodies Lama glama; Lotus japonicus lama glama lotus japonicus Gysel, K., Alsarraf, H.M.A.B., Hansen, S.B., Andersen, K.R. 2.19 X-RAY DIFFRACTION 0.252 0.204 False True IGHV1 NA NA None None None None None 9hlw H NA 0 E protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 Prostate Specific Membrane Antigen (PSMA) in complex with nanobody7 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Papo, N., Zarivach, R., Zalk, R. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hlw Q NA 0 A protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 Prostate Specific Membrane Antigen (PSMA) in complex with nanobody7 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Papo, N., Zarivach, R., Zalk, R. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hvi H NA 0 A protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 PSMA in complex with nanobody 8 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Zalk, R., Huynh, T.T., Zalutsky, M.R., Weizmann, Y., Zarivach, R., Papo, N. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hvi Q NA 0 E protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 PSMA in complex with nanobody 8 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Zalk, R., Huynh, T.T., Zalutsky, M.R., Weizmann, Y., Zarivach, R., Papo, N. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hvk H NA 0 E protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 PSMA in complex with nanobody 7 and 8 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Zalk, R., Huynh, T.T., Zalutsky, M.R., Weizmann, Y., Zarivach, R., Papo, N. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hvk Q NA 0 A protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 PSMA in complex with nanobody 7 and 8 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Zalk, R., Huynh, T.T., Zalutsky, M.R., Weizmann, Y., Zarivach, R., Papo, N. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hvk P NA 0 E protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 PSMA in complex with nanobody 7 and 8 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Zalk, R., Huynh, T.T., Zalutsky, M.R., Weizmann, Y., Zarivach, R., Papo, N. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hvk M NA 0 A protein NA glutamate carboxypeptidase 2 MEMBRANE PROTEIN 07/16/25 PSMA in complex with nanobody 7 and 8 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Alon, G., Zalk, R., Huynh, T.T., Zalutsky, M.R., Weizmann, Y., Zarivach, R., Papo, N. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9iqp B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/16/25 Crystal structure of the Wuhan SARS-CoV-2 Spike RBD (319-541) complexed with 1p1B10 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Matyuta, I.O., Dronova, E.A., Favorskaya, I.A., Esmagambetov, I.B., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 1.55 X-RAY DIFFRACTION 0.208 0.174 False True IGHV1 NA NA None None None None None 9j9z H L 0 A protein NA muropeptide transporter,soluble cytochrome b562 MEMBRANE PROTEIN 07/16/25 Cryo-EM structure of Outward state Anhydromuropeptide permease (AmpG) complex with GlcNAc-1,6-anhMurNAc Escherichia coli; Homo sapiens; synthetic construct; Yokenella regensburgei homo sapiens homo sapiens yokenella regensburgei, escherichia coli Chang, N., Kim, U., Cho, H. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9j9z K NA 0 NA NA NA NA MEMBRANE PROTEIN 07/16/25 Cryo-EM structure of Outward state Anhydromuropeptide permease (AmpG) complex with GlcNAc-1,6-anhMurNAc Escherichia coli; Homo sapiens; synthetic construct; Yokenella regensburgei synthetic construct Chang, N., Kim, U., Cho, H. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kgk E NA 0 A protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 07/16/25 Structure of the complex of LGR4 with NB18 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Geng, Y., Hu, F.Z., Qiao, H.R. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kgk B NA 0 A protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 07/16/25 Structure of the complex of LGR4 with NB18 Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Geng, Y., Hu, F.Z., Qiao, H.R. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9khh A NA 0 C protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 07/16/25 Structure of the complex of LGR4 with Norrin (2:2) Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Yong, G., Hu, F.Z., Qiao, H.R. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9khh B NA 0 D protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 07/16/25 Structure of the complex of LGR4 with Norrin (2:2) Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Yong, G., Hu, F.Z., Qiao, H.R. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uok A NA 0 C protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 07/16/25 Structure of the complex of LGR4_ECD with Norrin Camelus ferus; Homo sapiens camelus ferus homo sapiens Geng, Y., Hu, F.Z., Qiao, H.R. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9uxd D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/16/25 SARS-CoV2 Spike protein with Fab fragment antibody KXD355,state1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, H. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9uxd H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/16/25 SARS-CoV2 Spike protein with Fab fragment antibody KXD355,state1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, H. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9uxd J K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/16/25 SARS-CoV2 Spike protein with Fab fragment antibody KXD355,state1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, H. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9uxe D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/16/25 SARS-CoV2 Spike protein with Fab fragment antibody KXD355,state2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, H. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9uxe H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/16/25 SARS-CoV2 Spike protein with Fab fragment antibody KXD355,state2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, H. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9uxe J K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/16/25 SARS-CoV2 Spike protein with Fab fragment antibody KXD355,state2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, H. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9cjy G I 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 07/09/25 CryoEM structure of NC99 hemagglutinin trimer in complex with Fab BB798E 3-C07 Influenza A virus; Macaca fascicularis macaca fascicularis macaca fascicularis influenza a virus | influenza a virus Li, N., Tsybovsky, Y., Sangesland, M., Kanekiyo, M. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9cjy H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 07/09/25 CryoEM structure of NC99 hemagglutinin trimer in complex with Fab BB798E 3-C07 Influenza A virus; Macaca fascicularis macaca fascicularis macaca fascicularis influenza a virus | influenza a virus Li, N., Tsybovsky, Y., Sangesland, M., Kanekiyo, M. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9cjy J K 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 07/09/25 CryoEM structure of NC99 hemagglutinin trimer in complex with Fab BB798E 3-C07 Influenza A virus; Macaca fascicularis macaca fascicularis macaca fascicularis influenza a virus | influenza a virus Li, N., Tsybovsky, Y., Sangesland, M., Kanekiyo, M. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9cjz H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 07/09/25 CryoEM structure of NC99 hemagglutinin trimer in complex with Fab T009 3-E04 Influenza A virus; Macaca fascicularis macaca fascicularis macaca fascicularis influenza a virus | influenza a virus Li, N., Tsybovsky, Y., Sangesland, M., Kanekiyo, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9cjz J K 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 07/09/25 CryoEM structure of NC99 hemagglutinin trimer in complex with Fab T009 3-E04 Influenza A virus; Macaca fascicularis macaca fascicularis macaca fascicularis influenza a virus | influenza a virus Li, N., Tsybovsky, Y., Sangesland, M., Kanekiyo, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9cjz M N 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 07/09/25 CryoEM structure of NC99 hemagglutinin trimer in complex with Fab T009 3-E04 Influenza A virus; Macaca fascicularis macaca fascicularis macaca fascicularis influenza a virus | influenza a virus Li, N., Tsybovsky, Y., Sangesland, M., Kanekiyo, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8z9p S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/09/25 Cryo-EM structure of human GPR4-Gi complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | rattus norvegicus Chen, L.N., Zhou, H., Xi, K. 2.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9cr9 A B 0 C peptide NA circumsporozoite protein (npna)3 repeat region peptide IMMUNE SYSTEM 07/09/25 Crystal structure of MA6 Fab in complex with PfCSP repeat region peptide NPNA3 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Rush, S.A., McLellan, J.S. 1.8 X-RAY DIFFRACTION 0.215 0.185 False True IGHV3 IGKV1 Kappa None None None None None 9cr9 H L 0 P peptide NA circumsporozoite protein (npna)3 repeat region peptide IMMUNE SYSTEM 07/09/25 Crystal structure of MA6 Fab in complex with PfCSP repeat region peptide NPNA3 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Rush, S.A., McLellan, J.S. 1.8 X-RAY DIFFRACTION 0.215 0.185 False True IGHV3 IGKV1 Kappa None None None None None 9fm1 D NA 0 A protein NA hemagglutinin ANTIVIRAL PROTEIN 07/09/25 Cryo-EM structure of Influenza B/Washington/02/2019 virus hemagglutinin in complex with single-domain antibody hVHH-69. Influenza B virus; Lama glama lama glama influenza b virus Felix, J., Matthys, A., Savvides, S.N., Saelens, X. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fm1 E NA 0 C protein NA hemagglutinin ANTIVIRAL PROTEIN 07/09/25 Cryo-EM structure of Influenza B/Washington/02/2019 virus hemagglutinin in complex with single-domain antibody hVHH-69. Influenza B virus; Lama glama lama glama influenza b virus Felix, J., Matthys, A., Savvides, S.N., Saelens, X. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fm1 F NA 0 B protein NA hemagglutinin ANTIVIRAL PROTEIN 07/09/25 Cryo-EM structure of Influenza B/Washington/02/2019 virus hemagglutinin in complex with single-domain antibody hVHH-69. Influenza B virus; Lama glama lama glama influenza b virus Felix, J., Matthys, A., Savvides, S.N., Saelens, X. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fm2 A NA 0 B protein NA neuraminidase ANTIVIRAL PROTEIN 07/09/25 Cryo-EM structure of Influenza B/Washington/02/2019 virus neuraminidase in complex with single-domain antibody hVHH-525. Influenza B virus; Lama glama lama glama influenza b virus Felix, J., Matthys, A., Savvides, S.N., Saelens, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fvk NA A 0 NA NA NA NA IMMUNE SYSTEM 07/09/25 Crystal structure of amyloidogenic light chain AL-55 in open conformation. Homo sapiens homo sapiens Polsinelli, I., Puri, S., Broggini, L., Gadda, A., Petralia, U., Ricagno, S. 2.64 X-RAY DIFFRACTION 0.225 0.194 False True NA IGLV6 Lambda None None None None None 9fvk NA B 0 NA NA NA NA IMMUNE SYSTEM 07/09/25 Crystal structure of amyloidogenic light chain AL-55 in open conformation. Homo sapiens homo sapiens Polsinelli, I., Puri, S., Broggini, L., Gadda, A., Petralia, U., Ricagno, S. 2.64 X-RAY DIFFRACTION 0.225 0.194 False True NA IGLV6 Lambda None None None None None 9fvk NA C 0 NA NA NA NA IMMUNE SYSTEM 07/09/25 Crystal structure of amyloidogenic light chain AL-55 in open conformation. Homo sapiens homo sapiens Polsinelli, I., Puri, S., Broggini, L., Gadda, A., Petralia, U., Ricagno, S. 2.64 X-RAY DIFFRACTION 0.225 0.194 False True NA IGLV6 Lambda None None None None None 9lmo H L 0 R protein NA g-protein coupled receptor 4,soluble cytochrome b562 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/09/25 Cryo-EM structure of human apo inactive GPR4 Escherichia coli; Homo sapiens; synthetic construct homo sapiens homo sapiens homo sapiens, escherichia coli Chen, L.N., Zhou, H., Xi, K. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9lmo K NA 0 NA NA NA NA MEMBRANE PROTEIN/IMMUNE SYSTEM 07/09/25 Cryo-EM structure of human apo inactive GPR4 Escherichia coli; Homo sapiens; synthetic construct synthetic construct Chen, L.N., Zhou, H., Xi, K. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9mpw H L 0 S protein NA spike protein s2 IMMUNE SYSTEM 07/09/25 SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sapse, I.A., Bajic, G. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9mx1 B C 0 A protein NA toxin a TRANSFERASE,TOXIN/IMMUNE SYSTEM 07/09/25 Clostridioides difficile Toxin A with mCDIFA-248-25 Fab Clostridioides difficile; Mus musculus mus musculus mus musculus clostridioides difficile Huynh, K.W., Ammirati, M., Kroh, H.K., Lacy, D.B., Han, S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9nrc H L 0 A protein NA transmembrane protease serine 6 MEMBRANE PROTEIN 07/09/25 TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., Franklin, M.C. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9nrc C B 0 A protein NA transmembrane protease serine 6 MEMBRANE PROTEIN 07/09/25 TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., Franklin, M.C. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9rm2 H L 0 P protein NA major capsid protein vp1 VIRAL PROTEIN 07/09/25 BKPyV VP1 IN COMPLEX WITH 319C07-FAB Betapolyomavirus hominis; Homo sapiens homo sapiens homo sapiens betapolyomavirus hominis Schmitt, S., Hillenbrand, M. 1.96 X-RAY DIFFRACTION 0.218 0.187 False True IGHV4 IGKV3 Kappa None None None None None 9rm2 A B 0 C protein NA major capsid protein vp1 VIRAL PROTEIN 07/09/25 BKPyV VP1 IN COMPLEX WITH 319C07-FAB Betapolyomavirus hominis; Homo sapiens homo sapiens homo sapiens betapolyomavirus hominis Schmitt, S., Hillenbrand, M. 1.96 X-RAY DIFFRACTION 0.218 0.187 False True IGHV4 IGKV3 Kappa None None None None None 9rm2 D E 0 F protein NA major capsid protein vp1 VIRAL PROTEIN 07/09/25 BKPyV VP1 IN COMPLEX WITH 319C07-FAB Betapolyomavirus hominis; Homo sapiens homo sapiens homo sapiens betapolyomavirus hominis Schmitt, S., Hillenbrand, M. 1.96 X-RAY DIFFRACTION 0.218 0.187 False True IGHV4 IGKV3 Kappa None None None None None 9rm2 G J 0 K protein NA major capsid protein vp1 VIRAL PROTEIN 07/09/25 BKPyV VP1 IN COMPLEX WITH 319C07-FAB Betapolyomavirus hominis; Homo sapiens homo sapiens homo sapiens betapolyomavirus hominis Schmitt, S., Hillenbrand, M. 1.96 X-RAY DIFFRACTION 0.218 0.187 False True IGHV4 IGKV3 Kappa None None None None None 9rm2 M N 0 O protein NA major capsid protein vp1 VIRAL PROTEIN 07/09/25 BKPyV VP1 IN COMPLEX WITH 319C07-FAB Betapolyomavirus hominis; Homo sapiens homo sapiens homo sapiens betapolyomavirus hominis Schmitt, S., Hillenbrand, M. 1.96 X-RAY DIFFRACTION 0.218 0.187 False True IGHV4 IGKV3 Kappa None None None None None 9faj G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38, in a desensitised state (StateD1) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.6 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9faj P NA 0 D | C protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | isoform 2 of gamma-aminobutyric acid receptor subunitgamma-2 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38, in a desensitised state (StateD1) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.6 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fak G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD2) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.6 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fak P NA 0 D | C protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | isoform 2 of gamma-aminobutyric acid receptor subunitgamma-2 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD2) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.6 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fau K NA 0 A protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2 and Megabody25, in a closed state (StateC1) Homo sapiens; Lama glama lama glama homo sapiens Kasaragod, V.B., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fau O NA 0 E | D protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2 and Megabody25, in a closed state (StateC1) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fau F NA 0 A | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2 and Megabody25, in a closed state (StateC1) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9faw K NA 0 A protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, HEPES and Megabody25, in a desensitised state Homo sapiens; Lama glama lama glama homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9faw O NA 0 E | D protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, HEPES and Megabody25, in a desensitised state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9faw F NA 0 B protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, HEPES and Megabody25, in a desensitised state Homo sapiens; Lama glama lama glama homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pet F NA 0 E | D protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 Cryo-EM structure of the full-length human alpha1beta3 GABA(A) receptor (babba arrangement) in complex with nanobody Nb25, expressed with a 5-fold excess of beta3 over alpha1 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Sente, A., Malinauskas, T., Naydenova, K., Hardwick, S.W., Chirgadze, D.Y., Aricescu, A.R. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8vtd B A 0 C protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 07/02/25 Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen Homo sapiens; Mus musculus homo sapiens mus musculus homo sapiens Fischmann, T. 1.23 X-RAY DIFFRACTION 0.204 0.185 False True IGHV1 IGKV1 Kappa None None None None None 8vwe H L 0 C peptide NA transmembrane protein gp41 iqn17 peptide VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 HIV-1 neutralizing antibody D5_AR bound to HIV-1 gp41 coiled-coil pocket IQN17 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 m Filsinger Interrante, M.V., Tang, S., Fernandez, D., Kim, P.S. 2.2 X-RAY DIFFRACTION 0.257 0.205 False True IGHV1 IGKV1 Kappa None None None None None 8yvk E F 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Red knot/Delaware Bay/310/2016 H10N4 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus (A/red knot/Delaware Bay/310/2016(H10N4)) homo sapiens homo sapiens influenza a virus (a/red knot/delawarebay/310/2016(h10n4)) Wang, X., Ge, J., Li, X. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvk G H 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Red knot/Delaware Bay/310/2016 H10N4 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus (A/red knot/Delaware Bay/310/2016(H10N4)) homo sapiens homo sapiens influenza a virus (a/red knot/delawarebay/310/2016(h10n4)) Wang, X., Ge, J., Li, X. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvk I J 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Red knot/Delaware Bay/310/2016 H10N4 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus (A/red knot/Delaware Bay/310/2016(H10N4)) homo sapiens homo sapiens influenza a virus (a/red knot/delawarebay/310/2016(h10n4)) Wang, X., Ge, J., Li, X. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvk K L 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Red knot/Delaware Bay/310/2016 H10N4 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus (A/red knot/Delaware Bay/310/2016(H10N4)) homo sapiens homo sapiens influenza a virus (a/red knot/delawarebay/310/2016(h10n4)) Wang, X., Ge, J., Li, X. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvl I E 0 A protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/California/04/2009 HIN1 in complex with CAV-F34 Fab Homo sapiens; Influenza A virus (A/California/04/2009(H1N1)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/04/2009(h1n1)) Wang, X., Ge, J., Li, X. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvl L F 0 C protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/California/04/2009 HIN1 in complex with CAV-F34 Fab Homo sapiens; Influenza A virus (A/California/04/2009(H1N1)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/04/2009(h1n1)) Wang, X., Ge, J., Li, X. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvl K G 0 D protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/California/04/2009 HIN1 in complex with CAV-F34 Fab Homo sapiens; Influenza A virus (A/California/04/2009(H1N1)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/04/2009(h1n1)) Wang, X., Ge, J., Li, X. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvl J H 0 B protein NA vasodilator-stimulated phosphoprotein,neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/California/04/2009 HIN1 in complex with CAV-F34 Fab Homo sapiens; Influenza A virus (A/California/04/2009(H1N1)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/california/04/2009(h1n1)) Wang, X., Ge, J., Li, X. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvm F E 0 B | A protein | protein NA | NA neuraminidase | neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F34 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Wang, X., Ge, J., Li, X. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvn E I 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvn F J 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvn G K 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yvn H L 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8zyx F J 0 C | D protein | protein NA | NA neuraminidase | neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/Switzerland/9715293/2013 H3N2 in complex with CAV-F6-R54S Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Wang, X., Ge, J., Li, X. 2.33 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9btv H L 0 E | A | C protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Cryo-EM structure of rhesus antibody T646-a.01 in complex with HIV-1 Env trimer Q23.17 MD39 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L., Kwong, P.D. 3.48 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9ccs C B 0 A protein NA type 1 fimbiral adhesin fimh CELL ADHESION 07/02/25 CryoEM Structure of Escherichia coli FimCH in complex with 2H04 Fab Escherichia coli UTI89; Mus musculus mus musculus mus musculus escherichia coli uti89 Lopatto, E.D.B., Hultgren, S.J. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9cct C B 0 A protein NA type 1 fimbiral adhesin fimh CELL ADHESION 07/02/25 CryoEM Structure of Escherichia coli FimCH in complex with B7 Fab Escherichia coli UTI89; Mus musculus mus musculus mus musculus escherichia coli uti89 Lopatto, E.D.B., Hultgren, S.J. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9ccu C B 0 A protein NA type 1 fimbiral adhesin fimh CELL ADHESION 07/02/25 CryoEM Structure of Escherichia coli FimCH in complex with F7 Fab Escherichia coli UTI89; Mus musculus mus musculus mus musculus escherichia coli uti89 Lopatto, E.D.B., Hultgren, S.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9ccw C B 0 A protein NA type 1 fimbiral adhesin fimh CELL ADHESION 07/02/25 CryoEM Structure of Escherichia coli FimCH in complex with 2C07 Fab Escherichia coli UTI89; Mus musculus mus musculus mus musculus escherichia coli uti89 Lopatto, E.D.B., Hultgren, S.J. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV6 Kappa None None None None None 9cfe A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Cryo-EM Local Refinement of Antibody 19-77 in complex with prefusion SARS-CoV-2 Spike glycoprotein RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9cff H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Cryo-EM Refinement of Antibody 19-77 in complex with SARS-CoV-2 HK.3 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9cfg H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Cryo-EM Refinement of Antibody 19-77 R71V in complex with SARS-CoV-2 HK.3 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9cfh H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Cryo-EM Refinement of Antibody 19-77 R71V in complex with SARS-CoV-2 JD.1.1 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9fam G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD3) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 3.5 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fap G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9faq G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC2) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fat G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, Megabody38 and pregnenolone sulfate Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 3.6 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fax F NA 0 B | A protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/02/25 CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Kasaragod, V.B., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9iyy H L 0 B | A protein | protein NA | NA large envelope protein | large envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Structure of HBsAg in complex with Fab H006 HBV genotype D3; Homo sapiens homo sapiens homo sapiens hbv genotype d3 | hbv genotype d3 Chen, L., He, X. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9j8a H L 0 P peptide NA sulfated peptide from ccr5 IMMUNE SYSTEM 07/02/25 Structure of antibody BA8 in complex with sulfated peptide from CCR5 Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Ujiie, K., Tsumoto, K. 1.75 X-RAY DIFFRACTION 0.206 0.165 False True IGHV1 IGKV1 Kappa None None None None None 9jt1 H L 0 B protein NA large envelope protein IMMUNE SYSTEM/VIRAL PROTEIN 07/02/25 Structure of HBsAg in complex with FabHBC and FabGC1102 HBV genotype D3; Homo sapiens homo sapiens homo sapiens hbv genotype d3 Chen, L., He, X., Tao, W. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9jt1 C D 0 A protein NA large envelope protein IMMUNE SYSTEM/VIRAL PROTEIN 07/02/25 Structure of HBsAg in complex with FabHBC and FabGC1102 HBV genotype D3; Homo sapiens homo sapiens homo sapiens hbv genotype d3 Chen, L., He, X., Tao, W. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9kmi H L 0 A protein NA sodium- and chloride-dependent taurine transporter MEMBRANE PROTEIN/IMMUNE SYSTEM 07/02/25 Taurine bound mTAUT Mus musculus mus musculus mus musculus mus musculus She, J., Wang, M., He, J. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9kmj H L 0 A protein NA sodium- and chloride-dependent taurine transporter MEMBRANE PROTEIN/IMMUNE SYSTEM 07/02/25 Taurine bound hTAUT Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens She, J., Wang, M., He, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9kmk H L 0 A protein NA sodium- and chloride-dependent taurine transporter MEMBRANE PROTEIN/IMMUNE SYSTEM 07/02/25 apo mTAUT in inward open II state Mus musculus mus musculus mus musculus mus musculus She, J., Wang, M., He, J. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9kml H L 0 A protein NA sodium- and chloride-dependent taurine transporter MEMBRANE PROTEIN/IMMUNE SYSTEM 07/02/25 apo mTAUT in inward open I state Mus musculus mus musculus mus musculus mus musculus She, J., Wang, M., He, J. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9kmm H L 0 A protein NA sodium- and chloride-dependent taurine transporter MEMBRANE PROTEIN/IMMUNE SYSTEM 07/02/25 IAA bound mTAUT Mus musculus mus musculus mus musculus mus musculus She, J., Wang, M., He, J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9kod E F 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/dairy cow/Minnesota/24_016288-003/2024 (dcMN24 N1) in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9kod G H 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/dairy cow/Minnesota/24_016288-003/2024 (dcMN24 N1) in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9kod I J 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/dairy cow/Minnesota/24_016288-003/2024 (dcMN24 N1) in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9kod K L 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 Neuraminidase of A/dairy cow/Minnesota/24_016288-003/2024 (dcMN24 N1) in complex with CAV-F6 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, X., Ge, J., Li, X. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9kyo H L 0 A protein NA sodium- and chloride-dependent taurine transporter MEMBRANE PROTEIN/IMMUNE SYSTEM 07/02/25 GES bound mTAUT Mus musculus mus musculus mus musculus mus musculus She, J., Wang, M.X., He, J. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9nr8 E e 0 C protein NA glutamate receptor 1 MEMBRANE PROTEIN 07/02/25 The structure of cerebellar GluA1/A4 ATD Mus musculus; Rattus norvegicus mus musculus rattus norvegicus Fang, C.F., Gouaux, E. 3.53 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9nr8 F f 0 A protein NA glutamate receptor 1 MEMBRANE PROTEIN 07/02/25 The structure of cerebellar GluA1/A4 ATD Mus musculus; Rattus norvegicus mus musculus rattus norvegicus Fang, C.F., Gouaux, E. 3.53 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9u9b H L 0 B | A protein | protein NA | NA middle s protein | middle s protein VIRAL PROTEIN/IMMUNE SYSTEM 07/02/25 HBsAg in complex with HBC34 Fab Hepatitis B virus; Homo sapiens homo sapiens homo sapiens hepatitis b virus | hepatitis b virus Chen, L., He, X. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8rex G F 0 C protein NA transforming growth factor beta-1 proprotein IMMUNE SYSTEM 06/25/25 CryoEM structure of mouse GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody. Mus musculus mus musculus mus musculus mus musculus Felix, J., Lambert, F., Marien, L., van der Woning, B., Savvides, S.N., Lucas, S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8rex H I 0 A protein NA transforming growth factor beta-1 proprotein IMMUNE SYSTEM 06/25/25 CryoEM structure of mouse GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody. Mus musculus mus musculus mus musculus mus musculus Felix, J., Lambert, F., Marien, L., van der Woning, B., Savvides, S.N., Lucas, S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8s6k A a 0 M peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 06/25/25 Crystal structure of ScFv-G2D11 complexed to a bis-Tn glycopeptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens Hurtado-Guerrero, R., Macias-Leon, J. 1.75 X-RAY DIFFRACTION 0.221 0.182 True True unknown unknown unknown None None None None None 8s6k H h 0 N peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 06/25/25 Crystal structure of ScFv-G2D11 complexed to a bis-Tn glycopeptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens Hurtado-Guerrero, R., Macias-Leon, J. 1.75 X-RAY DIFFRACTION 0.221 0.182 True True unknown unknown unknown None None None None None 8s6t A B 0 C peptide NA mucin-1 subunit beta IMMUNE SYSTEM 06/25/25 Crystal structure of Fab-3F1 complexed to a bis-STn glycopeptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Hurtado-Guerrero, R., Gines, I. 1.85 X-RAY DIFFRACTION 0.267 0.230 False True IGHV1 IGKV6 Kappa None None None None None 8s6v A B 0 M peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 06/25/25 Crystal structure of Fab-2D9 chimera complexed to a bis-Tn glycopeptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Hurtado-Guerrero, R., Macias-Leon, J., Gonzalez-Ramirez, A. 1.95 X-RAY DIFFRACTION 0.244 0.199 False True IGHV1 IGKV8 Kappa None None None None None 8s6v C D 0 N peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 06/25/25 Crystal structure of Fab-2D9 chimera complexed to a bis-Tn glycopeptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Hurtado-Guerrero, R., Macias-Leon, J., Gonzalez-Ramirez, A. 1.95 X-RAY DIFFRACTION 0.244 0.199 False True IGHV1 IGKV8 Kappa None None None None None 8s73 A B 0 M peptide NA bis-tn glycopeptide IMMUNE SYSTEM 06/25/25 Crystal structure of Fab-antiCD43 monoclonal antibody complexed to a bis-Tn glycopeptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Hurtado-Guerrero, R., Macias-Leon, J. 2.2 X-RAY DIFFRACTION 0.237 0.195 False True IGHV1 IGKV12 Kappa None None None None None 8s73 C D 0 N peptide NA bis-tn glycopeptide IMMUNE SYSTEM 06/25/25 Crystal structure of Fab-antiCD43 monoclonal antibody complexed to a bis-Tn glycopeptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Hurtado-Guerrero, R., Macias-Leon, J. 2.2 X-RAY DIFFRACTION 0.237 0.195 False True IGHV1 IGKV12 Kappa None None None None None 8yry H L 0 A protein NA receptor tyrosine-protein kinase erbb-3 IMMUNE SYSTEM 06/25/25 HER3 in complex with FAb Hu3f8 Homo sapiens homo sapiens homo sapiens homo sapiens Wang, M., Li, X. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9bt5 C D 0 A protein NA hemagglutinin IMMUNE SYSTEM 06/25/25 The crystal structure of the HA1 domain of hemagglutinin from A/Shanghai/02/2013 (H7N9) bound to H7-235 Fab Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Buchman, C.D., Dong, J., Crowe, J.E. 2.5 X-RAY DIFFRACTION 0.251 0.195 False True IGHV3 IGKV2 Kappa None None None None None 9bt5 E F 0 B protein NA hemagglutinin IMMUNE SYSTEM 06/25/25 The crystal structure of the HA1 domain of hemagglutinin from A/Shanghai/02/2013 (H7N9) bound to H7-235 Fab Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Buchman, C.D., Dong, J., Crowe, J.E. 2.5 X-RAY DIFFRACTION 0.251 0.195 False True IGHV3 IGKV2 Kappa None None None None None 9cf6 H L 0 G protein NA germline-targeting hiv-1 gp120 engineered outer domaineodgt8 IMMUNE SYSTEM 06/25/25 Germline-targeting HIV-1 gp120 engineered outer domain eODgt8 in complex with Fab eOD-CL02.1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Stanfield, R.L., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.306 0.276 False True IGHV3 IGLV2 Lambda None None None None None 9cf7 H L 0 C protein NA germline-targeting hiv-1 gp120 engineered outer domaineodgt8 IMMUNE SYSTEM 06/25/25 Germline-targeting HIV-1 gp120 engineered outer domain eODgt8 in complex with Fab eOD-PL01.1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Stanfield, R.L., Wilson, I.A. 3.55 X-RAY DIFFRACTION 0.299 0.265 False True IGHV4 IGKV1 Kappa None None None None None 9cfa H L 0 C protein NA germline-targeting hiv-1 gp120 engineered outer domaineodgt8 IMMUNE SYSTEM 06/25/25 Germline-targeting HIV-1 gp120 engineered outer domain eODgt8 in complex with Fab eOD-CL04.1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Stanfield, R.L., Wilson, I.A. 3.06 X-RAY DIFFRACTION 0.259 0.224 False True IGHV3 IGLV7 Lambda None None None None None 9cfa B A 0 D protein NA germline-targeting hiv-1 gp120 engineered outer domaineodgt8 IMMUNE SYSTEM 06/25/25 Germline-targeting HIV-1 gp120 engineered outer domain eODgt8 in complex with Fab eOD-CL04.1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Stanfield, R.L., Wilson, I.A. 3.06 X-RAY DIFFRACTION 0.259 0.224 False True IGHV3 IGLV7 Lambda None None None None None 9cfa F E 0 G protein NA germline-targeting hiv-1 gp120 engineered outer domaineodgt8 IMMUNE SYSTEM 06/25/25 Germline-targeting HIV-1 gp120 engineered outer domain eODgt8 in complex with Fab eOD-CL04.1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Stanfield, R.L., Wilson, I.A. 3.06 X-RAY DIFFRACTION 0.259 0.224 False True IGHV3 IGLV7 Lambda None None None None None 9cpp F G 0 A protein NA spike protein s1 Viral Protein/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-17 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.19 X-RAY DIFFRACTION 0.279 0.232 False True IGHV3 IGKV3 Kappa None None None None None 9cpp H L 0 A protein NA spike protein s1 Viral Protein/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-17 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.19 X-RAY DIFFRACTION 0.279 0.232 False True IGHV5 IGKV4 Kappa None None None None None 9cpq F G 0 A protein NA spike protein s1 Viral Protein/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-44 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.88 X-RAY DIFFRACTION 0.251 0.202 False True IGHV3 IGKV3 Kappa None None None None None 9cpq H L 0 A protein NA spike protein s1 Viral Protein/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-44 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.88 X-RAY DIFFRACTION 0.251 0.202 False True IGHV5 IGKV4 Kappa None None None None None 9cpr F G 0 A protein NA spike protein s1 Viral Protein/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-90 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.247 0.194 False True IGHV3 IGKV3 Kappa None None None None None 9cpr H L 0 A protein NA spike protein s1 Viral Protein/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-90 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.247 0.194 False True IGHV5 IGKV4 Kappa None None None None None 9cps F G 0 A protein NA spike protein s1 IMMUNE SYSTEM/Viral Protein 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-91 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.03 X-RAY DIFFRACTION 0.253 0.215 False True IGHV3 IGKV3 Kappa None None None None None 9cps H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/Viral Protein 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-91 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.03 X-RAY DIFFRACTION 0.253 0.215 False True IGHV5 IGKV4 Kappa None None None None None 9cpt C G 0 A protein NA spike protein s1 IMMUNE SYSTEM/Viral Protein 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-92 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.51 X-RAY DIFFRACTION 0.269 0.221 False True IGHV3 IGKV3 Kappa None None None None None 9cpt H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/Viral Protein 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-92 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.51 X-RAY DIFFRACTION 0.269 0.221 False True IGHV5 IGKV4 Kappa None None None None None 9cpu H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0304 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.239 0.206 False True IGHV5 IGKV4 Kappa None None None None None 9cpu F G 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0304 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.239 0.206 False True IGHV3 IGKV3 Kappa None None None None None 9cpv H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0614 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3 X-RAY DIFFRACTION 0.262 0.207 False True IGHV5 IGKV4 Kappa None None None None None 9cpv C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0614 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3 X-RAY DIFFRACTION 0.262 0.207 False True IGHV3 IGKV3 Kappa None None None None None 9cpw H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C11-1036 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.234 0.185 False True IGHV5 IGKV4 Kappa None None None None None 9cpw C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C11-1036 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.234 0.185 False True IGHV3 IGKV3 Kappa None None None None None 9cpx H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0138 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.271 0.230 False True IGHV5 IGKV4 Kappa None None None None None 9cpx C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C03-0138 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.271 0.230 False True IGHV3 IGKV3 Kappa None None None None None 9cpy H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C11-0860 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.250 0.194 False True IGHV5 IGKV4 Kappa None None None None None 9cpy C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/25 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies C11-0860 and CC12.3 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.250 0.194 False True IGHV3 IGKV3 Kappa None None None None None 9d7u A NA 0 NA NA NA NA MEMBRANE PROTEIN 06/25/25 The low pH structure Homo sapiens homo sapiens Lu, M., Liu, B. 3.97 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9d7v A NA 0 NA NA NA NA MEMBRANE PROTEIN 06/25/25 The spd-bound structure Homo sapiens homo sapiens Lu, M., Liu, B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9d7w A NA 0 NA NA NA NA MEMBRANE PROTEIN 06/25/25 The TBZ-bound structure Homo sapiens homo sapiens Lu, M., Liu, B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9d7x A NA 0 NA NA NA NA MEMBRANE PROTEIN 06/25/25 The spm-bound structure Homo sapiens homo sapiens Lu, M., Liu, B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9dlf B A 0 C protein NA arabinosyltransferase aftb MEMBRANE PROTEIN 06/25/25 Arabinosyltransferase AftB in complex with Fab_B3 Homo sapiens; Mycolicibacterium chubuense homo sapiens homo sapiens mycolicibacterium chubuense Liu, Y., Mancia, F. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dm7 H L 0 A protein NA mannosyltransferase MEMBRANE PROTEIN 06/25/25 mannosyltransferase PimE in complex with Fab_E6 Homo sapiens; Mycobacteroides abscessus homo sapiens homo sapiens mycobacteroides abscessus Liu, Y. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o54 D C 0 A protein NA disintegrin and metalloproteinase domain-containing protein17 IMMUNE SYSTEM 06/25/25 ADAM17 Prodomain-Metalloproteinase Domains bound to MEDI3622 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Slone, C.E., Maciag, J.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9o58 D C 0 A protein NA disintegrin and metalloproteinase domain-containing protein17 IMMUNE SYSTEM 06/25/25 Zymogen ADAM17-iRhom2 complex bound by the MEDI3622 Fab Aequorea victoria; Homo sapiens homo sapiens homo sapiens homo sapiens Slone, C.E., Maciag, J.J. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9oao H L 0 C protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-0087 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 2.58 X-RAY DIFFRACTION 0.253 0.238 False True IGHV1 IGKV3 Kappa None None None None None 9oap H L 0 C protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-58 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.249 0.213 False True IGHV1 IGKV1 Kappa None None None None None 9oaq H L 0 C protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly-n276 IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-59 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly-N276 Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 2.54 X-RAY DIFFRACTION 0.230 0.208 False True IGHV1 IGKV3 Kappa None None None None None 9oar H L 0 C protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-179 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 1.94 X-RAY DIFFRACTION 0.248 0.213 False True IGHV1 IGKV1 Kappa None None None None None 9oar B D 0 A protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-179 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 1.94 X-RAY DIFFRACTION 0.248 0.213 False True IGHV1 IGKV1 Kappa None None None None None 9oas J K 0 M protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly-n276 IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-14 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly-N276 Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 2.79 X-RAY DIFFRACTION 0.255 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9oas H L 0 C protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly-n276 IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-14 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly-N276 Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 2.79 X-RAY DIFFRACTION 0.255 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9oas Q R 0 D protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly-n276 IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-14 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly-N276 Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 2.79 X-RAY DIFFRACTION 0.255 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9oas E F 0 P protein NA germline-targeting hiv-1 gp120 engineered outer domain eod-gt8-mingly-n276 IMMUNE SYSTEM 06/25/25 Crystal structure of antibody Fab G001-14 from IAVI G001 human trial in complex with a germline-targeting gp120 engineered outer domain eOD-GT8-mingly-N276 Homo sapiens homo sapiens homo sapiens homo sapiens Lin, X., Wilson, I.A. 2.79 X-RAY DIFFRACTION 0.255 0.214 False True IGHV1 IGKV1 Kappa None None None None None 9jq6 H I 0 F protein NA butyrophilin subfamily 2 member a1 IMMUNE SYSTEM 06/18/25 Cryo-EM structure of BTN2A1 in complex with antagonist antibody TH002 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhang, M., Wang, Y.Q., Xiao, J.Y. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9jq6 J K 0 E protein NA butyrophilin subfamily 2 member a1 IMMUNE SYSTEM 06/18/25 Cryo-EM structure of BTN2A1 in complex with antagonist antibody TH002 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhang, M., Wang, Y.Q., Xiao, J.Y. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9jqp H I 0 A protein NA butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 06/18/25 Cryo-EM structure of the HMBPP-primed BTN3A1-BTN3A2-BTN2A1 in complex with agonist antibody TH001 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhang, M., Wang, Y.Q., Xiao, J.Y. 3.34 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 9jqp J K 0 B | E protein | protein NA | NA butyrophilin subfamily 3 member a2 | butyrophilin subfamily 2 member a1 IMMUNE SYSTEM 06/18/25 Cryo-EM structure of the HMBPP-primed BTN3A1-BTN3A2-BTN2A1 in complex with agonist antibody TH001 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Zhang, M., Wang, Y.Q., Xiao, J.Y. 3.34 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8yot A NA 0 B protein NA lilrb3 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/18/25 Nanobody in complex with LILRB3 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Jin, C., Shi, Y. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8yot C NA 0 D protein NA lilrb3 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/18/25 Nanobody in complex with LILRB3 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Jin, C., Shi, Y. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9c7x A B 0 C peptide NA spike protein s2' IMMUNE SYSTEM 06/18/25 Crystal structure of SARS-CoV-2 antibody 1H06 in complex with a HR2 peptide Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Van Wazer, D.J., Zhou, T., Kwong, P.D. 1.96 X-RAY DIFFRACTION 0.215 0.172 False True IGHV1 IGKV1 Kappa None None None None None 9dmb C A 0 K protein NA envelope glycoprotein gp120 IMMUNE SYSTEM 06/18/25 Rhesus RHA10.01 Fab in complex with HIV-1 Env BG505 DS-SOSIP trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.27 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9dmb G B 0 F protein NA envelope glycoprotein gp120 IMMUNE SYSTEM 06/18/25 Rhesus RHA10.01 Fab in complex with HIV-1 Env BG505 DS-SOSIP trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.27 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9dmb H D 0 L protein NA envelope glycoprotein gp120 IMMUNE SYSTEM 06/18/25 Rhesus RHA10.01 Fab in complex with HIV-1 Env BG505 DS-SOSIP trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.27 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9fm0 A C 0 E protein NA type iii secretion protein pcrv IMMUNE SYSTEM 06/18/25 Human antibody (Fab) and P. aeruginosa (T3SS) protein PcrV-fragment complex Homo sapiens; Pseudomonas aeruginosa homo sapiens homo sapiens pseudomonas aeruginosa Desveaux, J.M., Contreras Martel, C., Dessen, A. 2.56 X-RAY DIFFRACTION 0.237 0.210 False True IGHV3 IGKV1 Kappa None None None None None 9fm0 B D 0 F protein NA type iii secretion protein pcrv IMMUNE SYSTEM 06/18/25 Human antibody (Fab) and P. aeruginosa (T3SS) protein PcrV-fragment complex Homo sapiens; Pseudomonas aeruginosa homo sapiens homo sapiens pseudomonas aeruginosa Desveaux, J.M., Contreras Martel, C., Dessen, A. 2.56 X-RAY DIFFRACTION 0.237 0.210 False True IGHV3 IGKV1 Kappa None None None None None 9fmw H L 0 A | B protein | protein NA | NA spike glycoprotein,fibritin | spike glycoprotein,fibritin VIRAL PROTEIN 06/18/25 Omicron BA.1 Spike protein with neutralizing NTD specific mAb K501SP6 Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 | severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Bjoernsson, K.H., Walker, M.R., Raghavan, S.S.R., Ward, A.B., Barfod, L.K. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9jqu H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/25 The crystal structure of SFTSV Gn and SD4 antibody complex Homo sapiens; SFTS virus JS4 homo sapiens homo sapiens sfts virus js4 Shi, W.F., Quan, C.S., Qi, J.X. 3.3 X-RAY DIFFRACTION 0.289 0.250 False True IGHV3 IGKV1 Kappa None None None None None 9jqv H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/25 The crystal structure of SFTSV Gn and SD12 antibody complex Homo sapiens; SFTS virus HB29 homo sapiens homo sapiens sfts virus hb29 Shi, W.F., Quan, C.S., Qi, J.X. 2.4 X-RAY DIFFRACTION 0.255 0.225 False True IGHV3 IGKV1 Kappa None None None None None 9jqv C D 0 B protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/25 The crystal structure of SFTSV Gn and SD12 antibody complex Homo sapiens; SFTS virus HB29 homo sapiens homo sapiens sfts virus hb29 Shi, W.F., Quan, C.S., Qi, J.X. 2.4 X-RAY DIFFRACTION 0.255 0.225 False True IGHV3 IGKV1 Kappa None None None None None 9l2k H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/25 The crystal structure of SFTSV Gn and SD22 antibody complex Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Shi, W.F., Quan, C.S., Qi, J.X. 2.78 X-RAY DIFFRACTION 0.312 0.304 False True IGHV3 IGKV1 Kappa None None None None None 8vsv 1 2 0 a | A protein | protein NA | NA unknown | e2 glycoprotein VIRUS 06/11/25 Cryo-EM structure of SINV/EEEV in complex with a potently neutralizing intact human antibody EEEV-373 Eastern equine encephalitis virus; Homo sapiens homo sapiens homo sapiens eastern equine encephalitis virus | eastern equine encephalitis virus Bandyopadhyay, A., Klose, T., Kuhn, R.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vsv 3 4 0 d | D protein | protein NA | NA unknown | e2 glycoprotein VIRUS 06/11/25 Cryo-EM structure of SINV/EEEV in complex with a potently neutralizing intact human antibody EEEV-373 Eastern equine encephalitis virus; Homo sapiens homo sapiens homo sapiens eastern equine encephalitis virus | eastern equine encephalitis virus Bandyopadhyay, A., Klose, T., Kuhn, R.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8y02 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 06/11/25 Cryo-EM structure of Short-wave-sensitive opsin 1 Bos taurus; Homo sapiens homo sapiens homo sapiens | homo sapiens Peng, Q., Jiang, H.H., Cheng, X.Y., Li, J., Zhang, J. 2.61 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zpq H L 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/25 Crystal structure of SARS-Cov-2-BQ1.1-RBD and 70fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wu, Y., Gao, F. 2.75 X-RAY DIFFRACTION 0.282 0.234 False True IGHV3 IGLV3 Lambda None None None None None 8zpq A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/25 Crystal structure of SARS-Cov-2-BQ1.1-RBD and 70fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wu, Y., Gao, F. 2.75 X-RAY DIFFRACTION 0.282 0.234 False True IGHV3 IGLV3 Lambda None None None None None 9ay1 1 2 0 a | A protein | protein NA | NA unknown | e2 glycoprotein VIRUS 06/11/25 Cryo-EM structure of SINV/EEEV in complex with a potently neutralizing human antibody IgG EEEV-373 Eastern equine encephalitis virus; Homo sapiens homo sapiens homo sapiens eastern equine encephalitis virus | eastern equine encephalitis virus Bandyopadhyay, A., Klose, T., Kuhn, R.J. 4.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9bth H L 0 D | F | G protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/25 Rhesus Fab 42056-a.01 in complex with CAP256SU.wk34 RnS SOSIP Env Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 9bti D E 0 H | G | C protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/25 Rhesus Fab 40591-a.01 in complex with T250.4 RnS SOSIP Env Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.14 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9btj H L 0 D | G | A protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/25 Rhesus Fab 6561-a.01 in complex with HIV-1 Ce1176.A3 RnS SOSIP Env Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV4 Lambda None None None None None 9byo N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of glucagon-like peptide-1 receptor (GLP-1R)-Gs complex with Exendin-asp3 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Zhang, X., Johnson, R., Belousoff, M.J., Danev, R., Sexton, P.M., Wootten, D. 2.31 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9c0k N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of glucagon-like peptide-1 receptor (GLP-1R)-Gs complex with Exendin-phe1 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Zhang, X., Johnson, R., Belousoff, M.J., Danev, R., Sexton, P.M., Wootten, D. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9cmc A B 0 E protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV2 Kappa None None None None None 9cmc C D 0 E protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 9cmc F G 0 J protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV2 Kappa None None None None None 9cmc H I 0 J protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 9cmc K L 0 O protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV2 Kappa None None None None None 9cmc M N 0 O protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 9cmc P Q 0 T protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV2 Kappa None None None None None 9cmc R V 0 T protein NA ara h 2 allergen ALLERGEN 06/11/25 Crystal structure of the peanut allergen Ara h 2 with two human derived Fab antibodies 22S1 and 23P34 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.95 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 9dbo H L 0 C protein NA serine/threonine-protein kinase mtor Transferase/Immune System 06/11/25 Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR Homo sapiens homo sapiens homo sapiens homo sapiens O'Leary, K.M., Slezak, T., Kossiakoff, A.A. 1.55 X-RAY DIFFRACTION 0.217 0.184 False True IGHV3 IGKV1 Kappa None None None None None 9dl0 A Y 0 G protein NA serine/threonine-protein kinase mtor IMMUNE SYSTEM/Transferase 06/11/25 Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR Homo sapiens homo sapiens homo sapiens homo sapiens O'Leary, K.M., Slezak, T., Kossiakoff, A.A. 2 X-RAY DIFFRACTION 0.234 0.205 False True IGHV3 IGKV1 Kappa None None None None None 9dl0 H Z 0 I protein NA serine/threonine-protein kinase mtor IMMUNE SYSTEM/Transferase 06/11/25 Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR Homo sapiens homo sapiens homo sapiens homo sapiens O'Leary, K.M., Slezak, T., Kossiakoff, A.A. 2 X-RAY DIFFRACTION 0.234 0.205 False True IGHV3 IGKV1 Kappa None None None None None 9fc2 B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 06/11/25 The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 4. Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Fernandez, L.A., Silva, K. 1.21 X-RAY DIFFRACTION 0.170 0.153 False True IGHV1 NA NA None None None None None 9fg0 F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric open 2 state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fgv B NA 0 A protein NA maltose/maltodextrin-binding periplasmic protein PROTEIN BINDING 06/11/25 Cryo-EM structure of MBP homo-dimer assembled by homo Di-Gluebody Escherichia coli; Lama glama lama glama escherichia coli Yi, G., Ye, M., Mamalis, D., Carrique, L., Fairhead, M., Li, H., Duerr, K., Zhang, P., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fgv D NA 0 C protein NA maltose/maltodextrin-binding periplasmic protein PROTEIN BINDING 06/11/25 Cryo-EM structure of MBP homo-dimer assembled by homo Di-Gluebody Escherichia coli; Lama glama lama glama escherichia coli Yi, G., Ye, M., Mamalis, D., Carrique, L., Fairhead, M., Li, H., Duerr, K., Zhang, P., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fgx C NA 0 D protein NA lysozyme c PROTEIN BINDING 06/11/25 Cryo-EM structure of Lysozyme homo-dimer assembled by homo Di-Gluebody Gallus gallus; Lama glama lama glama gallus gallus Yi, G., Ye, M., Mamalis, D., Carrique, L., Fairhead, M., Li, H., Duerr, K., Zhang, P., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.53 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fgx E NA 0 F protein NA lysozyme c PROTEIN BINDING 06/11/25 Cryo-EM structure of Lysozyme homo-dimer assembled by homo Di-Gluebody Gallus gallus; Lama glama lama glama gallus gallus Yi, G., Ye, M., Mamalis, D., Carrique, L., Fairhead, M., Li, H., Duerr, K., Zhang, P., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.53 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fgy C NA 0 D protein NA lysozyme c PROTEIN BINDING 06/11/25 Cryo-EM structure of Lysozyme homo-dimer assembled by homo Di-Gluebody - Local refinement Gallus gallus; Lama glama lama glama gallus gallus Yi, G., Ye, M., Mamalis, D., Carrique, L., Fairhead, M., Li, H., Duerr, K., Zhang, P., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.16 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9ghi H L 0 A protein NA pre-glycoprotein polyprotein gp complex VIRAL PROTEIN 06/11/25 Machupo virus GP1-GP2 heterodimer in complex with Fab of MAC1 Mammarenavirus machupoense; Mus musculus mus musculus mus musculus mammarenavirus machupoense Bowden, T.A., Paesen, G.C. 2.41 X-RAY DIFFRACTION 0.268 0.230 False True IGHV1 IGKV10 Kappa None None None None None 9ghj H L 0 A protein NA pre-glycoprotein polyprotein gp complex VIRAL PROTEIN 06/11/25 Junin virus GP1-GP2 heterodimer in complex with Fab of JUN1 Mammarenavirus juninense; Mus musculus mus musculus mus musculus mammarenavirus juninense Bowden, T.A., Paesen, G.C. 2.09 X-RAY DIFFRACTION 0.247 0.212 False True IGHV13 IGKV6 Kappa None None None None None 9gv4 A NA 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 TBA G-quadruplex binding nanobody (free form) Lama glama lama glama Pevec, M., Hadzi, S. 1.534 X-RAY DIFFRACTION 0.203 0.170 False True IGHV1 NA NA None None None None None 9gxh A NA 0 D nucleic-acid NA thrombin-binding aptamer (tba) IMMUNE SYSTEM 06/11/25 Nanobody bound to TBA G-quadruplex Lama glama; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S., Pevec, M. 1.9 X-RAY DIFFRACTION 0.199 0.154 False True IGHV1 NA NA None None None None None 9gxh B NA 0 D nucleic-acid NA thrombin-binding aptamer (tba) IMMUNE SYSTEM 06/11/25 Nanobody bound to TBA G-quadruplex Lama glama; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S., Pevec, M. 1.9 X-RAY DIFFRACTION 0.199 0.154 False True IGHV1 NA NA None None None None None 9k0k N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of UTP-bound P2Y purinoceptor 4-miniGq-Nb35 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Lan, B., Zhang, S., Liu, X., Lin, B. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9k0x N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of ATP-bound P2Y purinoceptor 2-miniGq-Nb35 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Lan, B., Zhang, S., Liu, X., Lin, B. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9k20 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of ATP-bound P2Y purinoceptor 2-miniGo-scFv16 complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Lan, B., Zhang, S., Liu, X., Lin, B. 2.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k25 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of apo-P2Y purinoceptor 2-miniGq-Nb35 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Lan, B., Zhang, S., Liu, X., Lin, B. 3.31 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9lrb N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of the histamine H1 receptor-Gs protein complex Bos taurus; Homo sapiens; Rattus norvegicus; unidentified unidentified homo sapiens | rattus norvegicus Matsuzaki, Y., Sano, F.K., Oshima, H.S., Akasaka, H., Kobayashi, K., Tanaka, T., Itoh, Y., Shihoya, W., Kise, Y., Kusakizako, T., Nureki, O. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9lrd E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of the histamine H1 receptor-Gi protein complex Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Matsuzaki, Y., Sano, F.K., Oshima, H.S., Akasaka, H., Kobayashi, K., Tanaka, T., Itoh, Y., Shihoya, W., Kise, Y., Kusakizako, T., Nureki, O. 3.23 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lre E e 0 B | A protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i) subunit alpha-1 MEMBRANE PROTEIN 06/11/25 Cryo-EM structure of the histamine H4 receptor-Gi protein complex (Overall) Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus rattus norvegicus | homo sapiens Matsuzaki, Y., Sano, F.K., Oshima, H.S., Akasaka, H., Kobayashi, K., Tanaka, T., Itoh, Y., Shihoya, W., Kise, Y., Kusakizako, T., Nureki, O. 2.84 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lux A a 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 Single-chain Fv antibody of G2 fused with antigen peptide from chicken prion protein Gallus gallus; Mus musculus gallus gallus, mus musculus Hanazono, Y., Yabuno, S., Hayashi, T., Numoto, N., Ito, N., Oda, M. 1.85 X-RAY DIFFRACTION 0.226 0.194 True True unknown unknown unknown None None None None None 9lux B b 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 Single-chain Fv antibody of G2 fused with antigen peptide from chicken prion protein Gallus gallus; Mus musculus gallus gallus, mus musculus Hanazono, Y., Yabuno, S., Hayashi, T., Numoto, N., Ito, N., Oda, M. 1.85 X-RAY DIFFRACTION 0.226 0.194 True True unknown unknown unknown None None None None None 9lux C c 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 Single-chain Fv antibody of G2 fused with antigen peptide from chicken prion protein Gallus gallus; Mus musculus gallus gallus, mus musculus Hanazono, Y., Yabuno, S., Hayashi, T., Numoto, N., Ito, N., Oda, M. 1.85 X-RAY DIFFRACTION 0.226 0.194 True True unknown unknown unknown None None None None None 9lux D d 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 Single-chain Fv antibody of G2 fused with antigen peptide from chicken prion protein Gallus gallus; Mus musculus gallus gallus, mus musculus Hanazono, Y., Yabuno, S., Hayashi, T., Numoto, N., Ito, N., Oda, M. 1.85 X-RAY DIFFRACTION 0.226 0.194 True True unknown unknown unknown None None None None None 9lux E e 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 Single-chain Fv antibody of G2 fused with antigen peptide from chicken prion protein Gallus gallus; Mus musculus gallus gallus, mus musculus Hanazono, Y., Yabuno, S., Hayashi, T., Numoto, N., Ito, N., Oda, M. 1.85 X-RAY DIFFRACTION 0.226 0.194 True True unknown unknown unknown None None None None None 9lux F f 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 Single-chain Fv antibody of G2 fused with antigen peptide from chicken prion protein Gallus gallus; Mus musculus gallus gallus, mus musculus Hanazono, Y., Yabuno, S., Hayashi, T., Numoto, N., Ito, N., Oda, M. 1.85 X-RAY DIFFRACTION 0.226 0.194 True True unknown unknown unknown None None None None None 9luy A a 0 NA NA NA NA IMMUNE SYSTEM 06/11/25 Single-chain Fv antibody of G2 fused with antigen peptide from chicken chromosome 6 C10orf76 homolog Gallus gallus; Mus musculus gallus gallus, mus musculus Hanazono, Y., Yabuno, S., Hayashi, T., Numoto, N., Ito, N., Oda, M. 1.62 X-RAY DIFFRACTION 0.188 0.167 True True unknown unknown unknown None None None None None 9qbj E F 0 I protein NA maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g BIOSYNTHETIC PROTEIN 06/11/25 Legobody dimer Escherichia coli; Mus musculus; Staphylococcus aureus subsp. aureus N315; Streptococcus sp. 'group G'; Vicugna pacos mus musculus mus musculus escherichia coli, staphylococcus aureus subsp.aureus n315, streptococcus sp. 'group g' Pacesa, M., Van Hall-Beauvais, A., Marchand, A., Georgeon, S., Correia, B.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 9qbj G H 0 J protein NA maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g BIOSYNTHETIC PROTEIN 06/11/25 Legobody dimer Escherichia coli; Mus musculus; Staphylococcus aureus subsp. aureus N315; Streptococcus sp. 'group G'; Vicugna pacos mus musculus mus musculus escherichia coli, staphylococcus aureus subsp.aureus n315, streptococcus sp. 'group g' Pacesa, M., Van Hall-Beauvais, A., Marchand, A., Georgeon, S., Correia, B.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 9qbj C NA 0 I protein NA maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g BIOSYNTHETIC PROTEIN 06/11/25 Legobody dimer Escherichia coli; Mus musculus; Staphylococcus aureus subsp. aureus N315; Streptococcus sp. 'group G'; Vicugna pacos vicugna pacos escherichia coli, staphylococcus aureus subsp.aureus n315, streptococcus sp. 'group g' Pacesa, M., Van Hall-Beauvais, A., Marchand, A., Georgeon, S., Correia, B.E. 3.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9qbj D NA 0 J protein NA maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g BIOSYNTHETIC PROTEIN 06/11/25 Legobody dimer Escherichia coli; Mus musculus; Staphylococcus aureus subsp. aureus N315; Streptococcus sp. 'group G'; Vicugna pacos vicugna pacos escherichia coli, staphylococcus aureus subsp.aureus n315, streptococcus sp. 'group g' Pacesa, M., Van Hall-Beauvais, A., Marchand, A., Georgeon, S., Correia, B.E. 3.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9qqn D C 0 A protein NA pre-glycoprotein polyprotein gp complex VIRAL PROTEIN 06/11/25 Junin virus GP1-GP2 heterodimer in complex with Fab of JUN1 Mammarenavirus juninense; Mus musculus mus musculus mus musculus mammarenavirus juninense Bowden, T.A., Paesen, G.C. 2.55 X-RAY DIFFRACTION 0.237 0.201 False True IGHV13 IGKV6 Kappa None None None None None 9u4w S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 cryo-EM structure of pig GnRHR bound with mammal GnRH Homo sapiens; Sus scrofa; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Shen, S., Xu, H.E. 3.18 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9u4y S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/25 cryo-EM structure of Xenopus laevis GnRHR bound with mammal GnRH Ateles; Homo sapiens; Xenopus laevis; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Shen, S., Xu, H.E. 2.67 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9fg1 F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric desensitised 2 state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fg1 G NA 0 D | C protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | isoform 1 of gamma-aminobutyric acid receptor subunitgamma-2 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric desensitised 2 state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fg3 F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 bound twice in the long-lived symmetric desensitised state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fg3 G NA 0 D | C protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | isoform 1 of gamma-aminobutyric acid receptor subunitgamma-2 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 bound twice in the long-lived symmetric desensitised state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xa4 C D 0 A | B protein | protein NA | NA protein opg161 | protein opg161 VIRAL PROTEIN 06/04/25 A35 of MPXV in complex with mAb981 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus | monkeypox virus Li, Y.N., Shi, T.H., Yan, R.H. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8z3y S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/04/25 Cryo-EM structure of of hGPR4-Gs complex in pH6.8 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhong, Y.N., Guo, L.L. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9b9e D NA 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN 06/04/25 Prefusion F glycoprotein ectodomain of Nipah virus ectodomain in complex with DS90 nanobody Henipavirus nipahense; Vicugna pacos vicugna pacos henipavirus nipahense Low, Y.S., Isaacs, A., Modhiran, N., Watterson, D. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9b9e E NA 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN 06/04/25 Prefusion F glycoprotein ectodomain of Nipah virus ectodomain in complex with DS90 nanobody Henipavirus nipahense; Vicugna pacos vicugna pacos henipavirus nipahense Low, Y.S., Isaacs, A., Modhiran, N., Watterson, D. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9b9e F NA 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN 06/04/25 Prefusion F glycoprotein ectodomain of Nipah virus ectodomain in complex with DS90 nanobody Henipavirus nipahense; Vicugna pacos vicugna pacos henipavirus nipahense Low, Y.S., Isaacs, A., Modhiran, N., Watterson, D. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cph H L 0 A protein NA induced myeloid leukemia cell differentiation protein mcl-1 APOPTOSIS 06/04/25 Structural basis of BAK sequestration by MCL-1 and consequences for apoptosis initiation Homo sapiens homo sapiens homo sapiens homo sapiens Uchikawa, E., Myasnikov, A., Dey, R., Moldoveanu, T. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9d7i H G 0 E protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 KN Fabs bound Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Parsons, R.J., Acharya, P. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9d7i J I 0 C protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 KN Fabs bound Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Parsons, R.J., Acharya, P. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9d7o H G 0 E protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Cryo-EM structure of BG505 DS-SOSIP.664 with 1 CH103 Fab bound Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Parsons, R.J., Acharya, P. 3.56 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9d7p H G 0 E protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 Fabs bound Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Parsons, R.J., Acharya, P. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9d7p J I 0 C protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 Fabs bound Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Parsons, R.J., Acharya, P. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ena B NA 0 A protein NA glucosylceramidase HYDROLASE 06/04/25 Lysosomal glucocerebrosidase in complex with a stabilizing nanobody Homo sapiens; Lama glama lama glama homo sapiens Dal Maso, T., Versees, W. 1.7 X-RAY DIFFRACTION 0.194 0.163 False True IGHV1 NA NA None None None None None 9ffl F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived symmetric pre-active state Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffm F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with Mb25 in the resting state Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffn F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric pre-active 1 state of branch 1 Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffq F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric desensitised state of branch 1 Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffr F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric pre-active state of branch 2 Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffs F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric open state of branch 2 Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffu F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the long-lived symmetric desensitised state Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffv F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with Nb38 in the long-lived symmetric resting state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffw F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived symmetric pre-active state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffy F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric open1 state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ffz F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric desensitised 1 state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fg2 F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the long-lived symmetric desensitised state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fga F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in SMALPs bound to two PIP2 molecules and in complex with Mb38 Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fgb F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in SMALPs bound to one PIP2 molecule at chain alpha1-A and in complex with Mb38 Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fgc F NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in SMALPs bound to one PIP2 molecule at chain alpha1-D and in complex with Mb38 Helicobacter pylori G27; Homo sapiens; Lama glama lama glama, helicobacter pylori g27 homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fgh G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 06/04/25 Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in large MSP2N2 nanodisc in complex with GABA in the long-lived symmetric desensitised state Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. 3.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9hb3 H L 0 R protein NA arginine-vasopressin (avp) v2 receptor (v2r)-bril,vasopressin v2 receptor,vasopressin v2 receptor MEMBRANE PROTEIN 06/04/25 cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with Mambaquaretin1 K39A (MQK39A) Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Bous, J., Fouillen, A., Couvineau, P., Orcel, H., Mary, C., Mendre, C., Schulte, G., Granier, S., Gilles, N., Mouillac, B. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9hb3 K NA 0 NA NA NA NA MEMBRANE PROTEIN 06/04/25 cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with Mambaquaretin1 K39A (MQK39A) Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens Bous, J., Fouillen, A., Couvineau, P., Orcel, H., Mary, C., Mendre, C., Schulte, G., Granier, S., Gilles, N., Mouillac, B. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9iut A B 0 C peptide NA h2mab-250 epitope peptide IMMUNE SYSTEM 06/04/25 Crystal structure of cancer-specific anti-HER2 antibody H2Mab-250 in complex with epitope peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Arimori, T., Takagi, J. 2.09 X-RAY DIFFRACTION 0.236 0.201 False True IGHV5 IGKV1 Kappa None None None None None 9iut D E 0 F peptide NA h2mab-250 epitope peptide IMMUNE SYSTEM 06/04/25 Crystal structure of cancer-specific anti-HER2 antibody H2Mab-250 in complex with epitope peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Arimori, T., Takagi, J. 2.09 X-RAY DIFFRACTION 0.236 0.201 False True IGHV5 IGKV1 Kappa None None None None None 9j0b S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/04/25 UDP-Glucose bound purinergic receptor P2Y14 in complex with Gi Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Wang, T.X., Gu, Q.C., Tang, W.Q. 2.88 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9j0i S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/04/25 UDP-Glucuronic acid bound purinergic receptor P2Y14 complex with Gi Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Wang, T.X., Gu, Q.C., Tang, W.Q. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ml4 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-A10 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml4 M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-A10 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml4 P Q 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-A10 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml5 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-B8 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml5 M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-B8 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml6 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C9 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml6 M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C9 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml6 P Q 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C9 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml7 H L 0 A | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C10 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ml8 E F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-B1 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.4 X-RAY DIFFRACTION 0.247 0.223 False True IGHV1 IGKV1 Kappa None None None None None 9ml8 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-B1 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.4 X-RAY DIFFRACTION 0.247 0.223 False True IGHV1 IGKV1 Kappa None None None None None 9ml8 M N 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-B1 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.4 X-RAY DIFFRACTION 0.247 0.223 False True IGHV1 IGKV1 Kappa None None None None None 9ml8 P Q 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-B1 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.4 X-RAY DIFFRACTION 0.247 0.223 False True IGHV1 IGKV1 Kappa None None None None None 9ml9 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/25 Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-C9 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.59 X-RAY DIFFRACTION 0.257 0.226 False True IGHV1 IGKV1 Kappa None None None None None 9ip7 D d 0 A protein NA epidermal growth factor receptor ANTITUMOR PROTEIN/IMMUNE SYSTEM 05/28/25 Local refinement structure of sEGFR and 528 Fv (from HL-type bispecific diabody Ex3) complex Homo sapiens; synthetic construct synthetic construct homo sapiens Sato, K., Uehara, S., Tsugita, A., Matsui, T., Asano, R., Makabe, K., Yokoyama, T., Tanaka, Y. 3.21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ipb D d 0 A protein NA epidermal growth factor receptor ANTITUMOR PROTEIN/IMMUNE SYSTEM 05/28/25 Local refinement structure of sEGFR and 528 Fv (from LH-type bispecific diabody Ex3) complex Homo sapiens; synthetic construct synthetic construct homo sapiens Sato, K., Uehara, S., Tsugita, A., Matsui, T., Asano, R., Makabe, K., Yokoyama, T., Tanaka, Y. 2.93 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8r4n H L 0 N protein NA short neurotoxin 1 ANTITOXIN 05/28/25 Crystal structure of neutralizing Fab Eq4.Dp46-3A from equine antivenom bound to short chain three finger alpha-neurotoxin from Dendroaspis polylepis. Dendroaspis polylepis; Equus caballus equus caballus equus caballus dendroaspis polylepis Wibmer, C.K. 2.2 X-RAY DIFFRACTION 0.228 0.206 False True unknown unknown unknown None None None None None 8vte B A 0 E protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 05/28/25 Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Fischmann, T., Bahmanjah, S. 2.29 X-RAY DIFFRACTION 0.268 0.229 False True IGHV6 IGKV4 Kappa None None None None None 8vte D C 0 F protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 05/28/25 Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Fischmann, T., Bahmanjah, S. 2.29 X-RAY DIFFRACTION 0.268 0.229 False True IGHV6 IGKV4 Kappa None None None None None 8zeu H L 0 C protein NA thymic stromal lymphopoietin IMMUNE SYSTEM 05/28/25 CryoEM structure of GR2002-F(ab')2: TSLP complex Homo sapiens homo sapiens homo sapiens homo sapiens Zhigang, L., Junjie, H. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8zeu A B 0 C protein NA thymic stromal lymphopoietin IMMUNE SYSTEM 05/28/25 CryoEM structure of GR2002-F(ab')2: TSLP complex Homo sapiens homo sapiens homo sapiens homo sapiens Zhigang, L., Junjie, H. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8zeu D E 0 G protein NA thymic stromal lymphopoietin IMMUNE SYSTEM 05/28/25 CryoEM structure of GR2002-F(ab')2: TSLP complex Homo sapiens homo sapiens homo sapiens homo sapiens Zhigang, L., Junjie, H. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8zeu I F 0 G protein NA thymic stromal lymphopoietin IMMUNE SYSTEM 05/28/25 CryoEM structure of GR2002-F(ab')2: TSLP complex Homo sapiens homo sapiens homo sapiens homo sapiens Zhigang, L., Junjie, H. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8zme E e 0 A | B protein | protein NA | NA engineered g13 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/28/25 Protease-activated receptor-2 (PAR2)/miniG13 complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Zhu, X. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8znt NA A 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znt NA B 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znt NA C 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znt NA D 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znt NA E 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znt NA F 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znt NA G 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znt NA H 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2.61 X-RAY DIFFRACTION 0.254 0.195 False True NA IGKV2 Kappa None None None None None 8znu NA A 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Catalytic antibody T99_C220A_dP95 Homo sapiens homo sapiens Kobayashi, J., Yoshida, H., Tsuyuguchi, M., Kato, R. 2 X-RAY DIFFRACTION 0.265 0.220 False True NA IGKV2 Kappa None None None None None 8zw0 N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/28/25 Cryo-EM strcuture of Prostaglandin D2 Receptor DP1 activated by PGD2 Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Xu, J., Xu, Y., Wu, C., Xu, H.E. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9c2k H L 0 R nucleic-acid NA rev response element RNA 05/28/25 The crystal structure of HIV-1 Rev Response Element Stem-Loop II in complex with a Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 2.42 X-RAY DIFFRACTION 0.265 0.206 False True IGHV3 IGKV1 Kappa None None None None None 9c2k A B 0 C nucleic-acid NA rev response element RNA 05/28/25 The crystal structure of HIV-1 Rev Response Element Stem-Loop II in complex with a Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 2.42 X-RAY DIFFRACTION 0.265 0.206 False True IGHV3 IGKV1 Kappa None None None None None 9c75 H L 0 R nucleic-acid NA rev response element RNA/IMMUNE SYSTEM 05/28/25 The crystal structure of HIV-1 Rev Response Element Stem-Loop II G34U mutant in complex with a Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 3.04 X-RAY DIFFRACTION 0.252 0.206 False True IGHV3 IGKV1 Kappa None None None None None 9cb1 A D 0 G protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 Cryo-EM Structure of the Human Neutralizing Antibody 5-1 in Complex with Prefusion Human Metapneumovirus F Glycoprotein Homo sapiens; human metapneumovirus homo sapiens homo sapiens human metapneumovirus Guo, L.Q., McLellan, J.S. 4.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9cb1 B E 0 H protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 Cryo-EM Structure of the Human Neutralizing Antibody 5-1 in Complex with Prefusion Human Metapneumovirus F Glycoprotein Homo sapiens; human metapneumovirus homo sapiens homo sapiens human metapneumovirus Guo, L.Q., McLellan, J.S. 4.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9cb1 C F 0 I protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 Cryo-EM Structure of the Human Neutralizing Antibody 5-1 in Complex with Prefusion Human Metapneumovirus F Glycoprotein Homo sapiens; human metapneumovirus homo sapiens homo sapiens human metapneumovirus Guo, L.Q., McLellan, J.S. 4.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9e7d H L 0 R nucleic-acid NA rev response element sliic RNA 05/28/25 Crystal structure of HIV-1 RRE SLII A31C mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 3.11 X-RAY DIFFRACTION 0.329 0.246 False True IGHV3 IGKV1 Kappa None None None None None 9e7d A B 0 C nucleic-acid NA rev response element sliic RNA 05/28/25 Crystal structure of HIV-1 RRE SLII A31C mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 3.11 X-RAY DIFFRACTION 0.329 0.246 False True IGHV3 IGKV1 Kappa None None None None None 9e7e H L 0 R nucleic-acid NA rev response element slii a31c/g39c RNA 05/28/25 Crystal structure of HIV-1 RRE SLII A31CG39C mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 2.75 X-RAY DIFFRACTION 0.293 0.250 False True IGHV3 IGKV1 Kappa None None None None None 9e7e A B 0 C nucleic-acid NA rev response element slii a31c/g39c RNA 05/28/25 Crystal structure of HIV-1 RRE SLII A31CG39C mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 2.75 X-RAY DIFFRACTION 0.293 0.250 False True IGHV3 IGKV1 Kappa None None None None None 9e7e D E 0 F nucleic-acid NA rev response element slii a31c/g39c RNA 05/28/25 Crystal structure of HIV-1 RRE SLII A31CG39C mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 2.75 X-RAY DIFFRACTION 0.293 0.250 False True IGHV3 IGKV1 Kappa None None None None None 9e7e G I 0 O nucleic-acid NA rev response element slii a31c/g39c RNA 05/28/25 Crystal structure of HIV-1 RRE SLII A31CG39C mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 2.75 X-RAY DIFFRACTION 0.293 0.250 False True IGHV3 IGKV1 Kappa None None None None None 9e7g H L 0 R nucleic-acid NA rev response element slii RNA 05/28/25 Crystal structure of HIV-1 RRE SLII G34C mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ojha, M., Koirala, D. 3 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV1 Kappa None None None None None 9isf B NA 0 A protein NA glycoprotein d ANTIVIRAL PROTEIN 05/28/25 Crystal structure of nanobody 14 in complex with HSV-2 gD Human alphaherpesvirus 2; Vicugna pacos vicugna pacos human alphaherpesvirus 2 Hu, J., Jin, T.C. 3.72 X-RAY DIFFRACTION 0.347 0.301 False True IGHV1 NA NA None None None None None 9ish D NA 0 C protein NA glycoprotein d ANTIVIRAL PROTEIN 05/28/25 Crystal structure of nanobody 32 in complex with HSV-2 gD Human alphaherpesvirus 2; Vicugna pacos vicugna pacos human alphaherpesvirus 2 Hu, J., Jin, T.C. 2.88 X-RAY DIFFRACTION 0.276 0.216 False True IGHV1 NA NA None None None None None 9ish B NA 0 A protein NA glycoprotein d ANTIVIRAL PROTEIN 05/28/25 Crystal structure of nanobody 32 in complex with HSV-2 gD Human alphaherpesvirus 2; Vicugna pacos vicugna pacos human alphaherpesvirus 2 Hu, J., Jin, T.C. 2.88 X-RAY DIFFRACTION 0.276 0.216 False True IGHV1 NA NA None None None None None 9jmd E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 05/28/25 Cryo-EM structure of the Azithromycin-Motilin receptor-Gq protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, H.E., You, C., Jiang, Y. 2.74 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mic H L 0 C protein NA eod-gt8 engineered mutant of gp120 IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 4D01, derived from GT1.1 vaccination, in complex with eOD-GT8 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Agrawal, S., Wilson, I.A. 1.97 X-RAY DIFFRACTION 0.252 0.222 False True IGHV1 IGKV1 Kappa None None None None None 9mid H L 0 C protein NA eod-gt8 engineered mutant of gp120 IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 3G08, derived from GT1.1 vaccination, in complex with eOD-GT8 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Agrawal, S., Wilson, I.A. 1.74 X-RAY DIFFRACTION 0.247 0.206 False True IGHV1 IGLV2 Lambda None None None None None 9mif H L 0 C protein NA eod-gt8 engineered mutant of gp120 IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 9C09, derived from GT1.1 vaccination, in complex with eOD-GT8 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Agrawal, S., Wilson, I.A. 1.93 X-RAY DIFFRACTION 0.275 0.233 False True IGHV1 IGKV1 Kappa None None None None None 9mj3 H L 0 C protein NA eod-gt8 engineered mutant of gp120 IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 12A01, derived from GT1.1 vaccination, in complex with eOD-GT8 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Agrawal, S., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.246 0.217 False True IGHV1 IGKV3 Kappa None None None None None 9mj6 H L 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 7A03 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3.06 X-RAY DIFFRACTION 0.324 0.264 False True IGHV1 IGLV2 Lambda None None None None None 9mj6 E F 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 7A03 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3.06 X-RAY DIFFRACTION 0.324 0.264 False True IGHV1 IGLV2 Lambda None None None None None 9mjc H L 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 4D01 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.284 0.247 False True IGHV1 IGKV1 Kappa None None None None None 9mjc E F 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 4D01 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.284 0.247 False True IGHV1 IGKV1 Kappa None None None None None 9mjd P R 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 3G08 Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3.5 X-RAY DIFFRACTION 0.343 0.306 False True IGHV1 IGLV2 Lambda None None None None None 9mjd E F 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 3G08 Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3.5 X-RAY DIFFRACTION 0.343 0.306 False True IGHV1 IGLV2 Lambda None None None None None 9mjd I J 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 3G08 Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3.5 X-RAY DIFFRACTION 0.343 0.306 False True IGHV1 IGLV2 Lambda None None None None None 9mjd M N 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 3G08 Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3.5 X-RAY DIFFRACTION 0.343 0.306 False True IGHV1 IGLV2 Lambda None None None None None 9mji H L 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 9C09 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.279 0.232 False True IGHV1 IGKV1 Kappa None None None None None 9mji C D 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 9C09 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.279 0.232 False True IGHV1 IGKV1 Kappa None None None None None 9mk4 H L 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 12A01 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3 X-RAY DIFFRACTION 0.294 0.239 False True IGHV1 IGKV3 Kappa None None None None None 9mk4 C D 0 NA NA NA NA IMMUNE SYSTEM 05/28/25 Crystal structure of the VRC01-class antibody 12A01 derived from GT1.1 vaccination Homo sapiens homo sapiens homo sapiens Agrawal, S., Wilson, I.A. 3 X-RAY DIFFRACTION 0.294 0.239 False True IGHV1 IGKV3 Kappa None None None None None 9msy G I 0 A protein NA v703-0537_t278m_l14 sosip VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 G002-480-0546 Fab in complex with V703-0537_T278M_L14 SOSIP and BG18 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGLV3 Lambda None None None None None 9msy H L 0 A protein NA v703-0537_t278m_l14 sosip VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 G002-480-0546 Fab in complex with V703-0537_T278M_L14 SOSIP and BG18 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9msy J M 0 B protein NA v703-0537_t278m_l14 sosip VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 G002-480-0546 Fab in complex with V703-0537_T278M_L14 SOSIP and BG18 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGLV3 Lambda None None None None None 9msy K N 0 B protein NA v703-0537_t278m_l14 sosip VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 G002-480-0546 Fab in complex with V703-0537_T278M_L14 SOSIP and BG18 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9msy O Q 0 C protein NA v703-0537_t278m_l14 sosip VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 G002-480-0546 Fab in complex with V703-0537_T278M_L14 SOSIP and BG18 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGLV3 Lambda None None None None None 9msy P R 0 C protein NA v703-0537_t278m_l14 sosip VIRAL PROTEIN/IMMUNE SYSTEM 05/28/25 G002-480-0546 Fab in complex with V703-0537_T278M_L14 SOSIP and BG18 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9nk9 A NA 0 B peptide NA ser-phe-glu-asp-phe-trp-lys-gly-glu-asp IMMUNE SYSTEM 05/28/25 Nano-body peptide complex Lama glama; SYNTHETIC CONSTRUCT lama glama synthetic construct Zhao, G., Cheloha, R.W., Bewley, C.A. 2.1 X-RAY DIFFRACTION 0.214 0.172 False True IGHV1 NA NA None None None None None 9mih H L 0 A protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN 05/21/25 273-4D01 Fab in complex with HIV-1 BG505 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta human immunodeficiency virus 1 homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9mih G I 0 D protein NA envelope glycoprotein gp160 VIRAL PROTEIN 05/21/25 273-4D01 Fab in complex with HIV-1 BG505 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mih J K 0 F | C protein | protein NA | NA envelope glycoprotein gp160 | hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN 05/21/25 273-4D01 Fab in complex with HIV-1 BG505 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mih M N 0 B | E protein | protein NA | NA envelope glycoprotein gp160 | hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN 05/21/25 273-4D01 Fab in complex with HIV-1 BG505 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8s2t N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/21/25 Cryo-EM structure of cell-free synthesized Human beta-1 adrenergic receptor cotranslationally inserted into a lipidic nanodiscs Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Merino, F., Koeck, Z., Ermel, U., Dahlhaus, P., Doetsch, V., Kubicek, J., Frangakis, A.S., Hilger, D., Bernhard, F. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8yaf B NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf C NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf E NA 0 D protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf F NA 0 D protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf I NA 0 H protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf J NA 0 H protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf M NA 0 L protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf N NA 0 L protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf Q NA 0 P protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf R NA 0 P protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf U NA 0 T protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 8yaf V NA 0 T protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 05/21/25 SOD1, Nanobody1 and Nanobody2 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.28 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 9btl H L 0 E | I | A protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Cryo-EM structure of rhesus antibody 41328-a.01 in complex with HIV-1 Env BG505 DS-SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L., Kwong, P.D. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9cu5 D E 0 A protein NA hiv env jrfl nfl td cc3+ gp140 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 LJF-085 Fab in complex with HIV Env JRFL NFL TD CC3+ trimer and 35O22 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9cu5 F G 0 C protein NA hiv env jrfl nfl td cc3+ gp140 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 LJF-085 Fab in complex with HIV Env JRFL NFL TD CC3+ trimer and 35O22 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9cu5 J K 0 B protein NA hiv env jrfl nfl td cc3+ gp140 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 LJF-085 Fab in complex with HIV Env JRFL NFL TD CC3+ trimer and 35O22 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9cu5 H L 0 B protein NA hiv env jrfl nfl td cc3+ gp140 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 LJF-085 Fab in complex with HIV Env JRFL NFL TD CC3+ trimer and 35O22 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cu5 I M 0 C protein NA hiv env jrfl nfl td cc3+ gp140 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 LJF-085 Fab in complex with HIV Env JRFL NFL TD CC3+ trimer and 35O22 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9cv7 H L 0 B | C protein | protein NA | NA zm233 nfl td cc3+ gp140 | zm233 nfl td cc3+ gp140 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 LJF-085 Fab in complex with HIV Env ZM233 NFL TD CC3+ trimer Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9ehl G J 0 A protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9ehl H K 0 B protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9ehl I L 0 C protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9ehl M P 0 A protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9ehl N Q 0 B protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9ehl O R 0 C protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9ehm H K 0 B protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class II Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9ehm I L 0 C protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class II Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9ehm M P 0 A protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class II Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9ehm N Q 0 B protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class II Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9ehm O R 0 C protein NA hiv-1 bg505 sosip gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/21/25 Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class II Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Yang, Z., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9f90 A B 0 H protein NA rsvf-multi-epitope designed scaffold DE NOVO PROTEIN 05/21/25 Crystal structure of a designed three-motif Respiratory Syncytial Virus immunogen in complex with motavizumab fab Mus musculus; synthetic construct mus musculus mus musculus synthetic construct Castro, K.M., Correia, B.E. 2.91 X-RAY DIFFRACTION 0.262 0.224 False True IGHV2 IGKV1 Kappa None None None None None 9f90 D C 0 G protein NA rsvf-multi-epitope designed scaffold DE NOVO PROTEIN 05/21/25 Crystal structure of a designed three-motif Respiratory Syncytial Virus immunogen in complex with motavizumab fab Mus musculus; synthetic construct mus musculus mus musculus synthetic construct Castro, K.M., Correia, B.E. 2.91 X-RAY DIFFRACTION 0.262 0.224 False True IGHV2 IGKV1 Kappa None None None None None 9f91 E F 0 I protein NA designed single epitope respiratory syncytial virusimmunogen in complex with rsv90 fab DE NOVO PROTEIN 05/21/25 Crystal structure of a designed Respiratory Syncytial Virus immunogen in complex with RSV90 fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Castro, K.M., Correia, B.E. 2.43 X-RAY DIFFRACTION 0.287 0.251 False True IGHV3 IGKV3 Kappa None None None None None 9f91 A B 0 J protein NA designed single epitope respiratory syncytial virusimmunogen in complex with rsv90 fab DE NOVO PROTEIN 05/21/25 Crystal structure of a designed Respiratory Syncytial Virus immunogen in complex with RSV90 fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Castro, K.M., Correia, B.E. 2.43 X-RAY DIFFRACTION 0.287 0.251 False True IGHV3 IGKV3 Kappa None None None None None 9fcm A NA 0 E peptide NA spike protein s2' ANTIVIRAL PROTEIN 05/21/25 Single-domain antibody binding the SARS-COV2 S2 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Vann Molle, I., Remaut, H. 1.94 X-RAY DIFFRACTION 0.247 0.200 False True IGHV1 NA NA None None None None None 9fcm B NA 0 F peptide NA spike protein s2' ANTIVIRAL PROTEIN 05/21/25 Single-domain antibody binding the SARS-COV2 S2 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Vann Molle, I., Remaut, H. 1.94 X-RAY DIFFRACTION 0.247 0.200 False True IGHV1 NA NA None None None None None 9fcm C NA 0 D peptide NA spike protein s2' ANTIVIRAL PROTEIN 05/21/25 Single-domain antibody binding the SARS-COV2 S2 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Vann Molle, I., Remaut, H. 1.94 X-RAY DIFFRACTION 0.247 0.200 False True IGHV1 NA NA None None None None None 9fkn B NA 0 A protein NA monocarboxylate transporter 8 TRANSPORT PROTEIN 05/21/25 Human monocarboxylate transporter 8 bound to thyroxine Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Coscia, F., Tassinari, M. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9fyr D NA 0 A protein NA synaptic vesicle glycoprotein 2a MEMBRANE PROTEIN 05/21/25 Cryo-EM structure of native SV2A in complex with TeNT-Hc, Pro-Macrobody 5 and Levetiracetam Clostridium tetani E88; Escherichia coli K-12; Lama glama; Ovis aries lama glama, escherichia coli k-12 ovis aries Schenck, S., Brunner, J.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9g6x C NA 0 A | B protein | protein NA | NA protein tweety homolog 2 | protein tweety homolog 2 MEMBRANE PROTEIN 05/21/25 TTYH2 in complex with sybody 1 in GDN Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Sukalskaia, A., Weber, F., Plochberger, B., Dutzler, R. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9gf8 B NA 0 A protein NA monocarboxylate transporter 8 TRANSPORT PROTEIN 05/21/25 Human Monocarboxylate Transporter 8 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Coscia, F., Tassinari, M. 3.5 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9gry B b 0 A protein NA human slc35b1-q113f TRANSPORT PROTEIN 05/21/25 Cryo-EM structure of human SLC35B1-Q113F variant with AMP-PNP Homo sapiens; Mus musculus mus musculus homo sapiens Gulati, A., Ahn, D., Suades, A., Drew, D. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9gs3 A a 0 B protein NA slc35b1-e33a inward facing conformation TRANSPORT PROTEIN 05/21/25 Cryo-EM structure of human SLC35B1-E33A variant with ADP in inward facing conformation Homo sapiens; Mus musculus mus musculus homo sapiens Gulati, A., Ahn, D., Suades, A., Drew, D. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9gs5 B b 0 A protein NA solute carrier family 35 member b1 TRANSPORT PROTEIN 05/21/25 Cryo-EM structure of human SLC35B1-E33A variant with ADP in outward facing conformation Homo sapiens; Mus musculus mus musculus homo sapiens Gulati, A., Ahn, D., Suades, A., Drew, D. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9gs7 B b 0 A protein NA solute carrier family 35 member b1 TRANSPORT PROTEIN 05/21/25 Cryo-EM structure of human SLC35B1-E33A variant with AMP-PNP Homo sapiens; Mus musculus mus musculus homo sapiens Gulati, A., Ahn, D., Suades, A., Drew, D. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9gsl B b 0 A protein NA solute carrier family 35 member b1 TRANSPORT PROTEIN 05/21/25 Cryo-EM structure of human SLC35B1 in inward facing conformation Homo sapiens; Mus musculus mus musculus homo sapiens Gulati, A., Ahn, D., Suades, A., Drew, D. 3.37 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9i20 B b 0 A protein NA solute carrier family 35 member b1 TRANSPORT PROTEIN 05/21/25 Cryo-EM structure of human SLC35B1 with ADP Homo sapiens; Mus musculus mus musculus homo sapiens Gulati, A., Ahn, D., Suades, A., Drew, D. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9mdz E NA 0 NA NA NA NA IMMUNE SYSTEM 05/21/25 anti-IL23R VHH Lama glama lama glama Kiefer, J.R., Koerber, J.T., Ota, N., Davies, C., Wallweber, H.A. 1.27 X-RAY DIFFRACTION 0.159 0.145 False True IGHV3 NA NA None None None None None 9mfg E NA 0 D protein NA interleukin-23 receptor IMMUNE SYSTEM 05/21/25 Complex of IL23 receptor and VHH Homo sapiens; Lama glama lama glama homo sapiens Kiefer, J.R., Wallweber, H.A., Koerber, J.T., Ota, N., Davies, C. 2.85 X-RAY DIFFRACTION 0.246 0.204 False True IGHV3 NA NA None None None None None 9mfg F NA 0 C protein NA interleukin-23 receptor IMMUNE SYSTEM 05/21/25 Complex of IL23 receptor and VHH Homo sapiens; Lama glama lama glama homo sapiens Kiefer, J.R., Wallweber, H.A., Koerber, J.T., Ota, N., Davies, C. 2.85 X-RAY DIFFRACTION 0.246 0.204 False True IGHV3 NA NA None None None None None 9mfg G NA 0 A protein NA interleukin-23 receptor IMMUNE SYSTEM 05/21/25 Complex of IL23 receptor and VHH Homo sapiens; Lama glama lama glama homo sapiens Kiefer, J.R., Wallweber, H.A., Koerber, J.T., Ota, N., Davies, C. 2.85 X-RAY DIFFRACTION 0.246 0.204 False True IGHV3 NA NA None None None None None 9mfg H NA 0 B protein NA interleukin-23 receptor IMMUNE SYSTEM 05/21/25 Complex of IL23 receptor and VHH Homo sapiens; Lama glama lama glama homo sapiens Kiefer, J.R., Wallweber, H.A., Koerber, J.T., Ota, N., Davies, C. 2.85 X-RAY DIFFRACTION 0.246 0.204 False True IGHV3 NA NA None None None None None 9mi0 H L 0 A protein NA gt1.1 v4.1 sosip gp120 VIRAL PROTEIN 05/21/25 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mi0 G I 0 F protein NA envelope glycoprotein gp160 VIRAL PROTEIN 05/21/25 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mi0 K N 0 C protein NA gt1.1 v4.1 sosip gp120 VIRAL PROTEIN 05/21/25 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mi0 J M 0 B protein NA envelope glycoprotein gp160 VIRAL PROTEIN 05/21/25 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mi0 P R 0 E protein NA gt1.1 v4.1 sosip gp120 VIRAL PROTEIN 05/21/25 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9mi0 O Q 0 D protein NA envelope glycoprotein gp160 VIRAL PROTEIN 05/21/25 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mib G I 0 F protein NA envelope glycoprotein gp160 VIRAL PROTEIN 05/21/25 206-9C09 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mib H L 0 A protein NA gt1.1 v4.1 sosip gp120 VIRAL PROTEIN 05/21/25 206-9C09 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9mib J M 0 B protein NA envelope glycoprotein gp160 VIRAL PROTEIN 05/21/25 206-9C09 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mib K N 0 C protein NA gt1.1 v4.1 sosip gp120 VIRAL PROTEIN 05/21/25 206-9C09 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9mib O Q 0 D protein NA envelope glycoprotein gp160 VIRAL PROTEIN 05/21/25 206-9C09 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mib P R 0 E protein NA gt1.1 v4.1 sosip gp120 VIRAL PROTEIN 05/21/25 206-9C09 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 Phulera, S., Ozorowski, G., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8zh7 B C 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 05/14/25 Crystal structure of N-terminal domain of N-methyl-D-aspartate receptor subunit NR1 in complex with patient-derived antibody Homo sapiens homo sapiens homo sapiens homo sapiens Nomura, N., Kumazaki, K., Amano, Y. 3.5 X-RAY DIFFRACTION 0.227 0.186 False True IGHV4 IGLV6 Lambda None None None None None 8zh7 E F 0 D protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 05/14/25 Crystal structure of N-terminal domain of N-methyl-D-aspartate receptor subunit NR1 in complex with patient-derived antibody Homo sapiens homo sapiens homo sapiens homo sapiens Nomura, N., Kumazaki, K., Amano, Y. 3.5 X-RAY DIFFRACTION 0.227 0.186 False True IGHV4 IGLV6 Lambda None None None None None 8zh7 H I 0 G protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 05/14/25 Crystal structure of N-terminal domain of N-methyl-D-aspartate receptor subunit NR1 in complex with patient-derived antibody Homo sapiens homo sapiens homo sapiens homo sapiens Nomura, N., Kumazaki, K., Amano, Y. 3.5 X-RAY DIFFRACTION 0.227 0.186 False True IGHV4 IGLV6 Lambda None None None None None 8zh7 K L 0 J protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 05/14/25 Crystal structure of N-terminal domain of N-methyl-D-aspartate receptor subunit NR1 in complex with patient-derived antibody Homo sapiens homo sapiens homo sapiens homo sapiens Nomura, N., Kumazaki, K., Amano, Y. 3.5 X-RAY DIFFRACTION 0.227 0.186 False True IGHV4 IGLV6 Lambda None None None None None 9c2h B C 0 D protein NA nucleoprotein VIRAL PROTEIN 05/14/25 SARS-CoV-2 Nucleocapsid Dimerization Domain bound to Fab-NP1E9 and Fab-NP3B4 Mus sp.; Severe acute respiratory syndrome coronavirus 2 mus sp. mus sp. severe acute respiratory syndrome coronavirus2 Landeras-Bueno, S., Hariharan, C., Diaz Avalos, R., Ollmann Saphire, E. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV4 Kappa None None None None None 9c2h E F 0 A protein NA nucleoprotein VIRAL PROTEIN 05/14/25 SARS-CoV-2 Nucleocapsid Dimerization Domain bound to Fab-NP1E9 and Fab-NP3B4 Mus sp.; Severe acute respiratory syndrome coronavirus 2 mus sp. mus sp. severe acute respiratory syndrome coronavirus2 Landeras-Bueno, S., Hariharan, C., Diaz Avalos, R., Ollmann Saphire, E. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9c2h G H 0 A protein NA nucleoprotein VIRAL PROTEIN 05/14/25 SARS-CoV-2 Nucleocapsid Dimerization Domain bound to Fab-NP1E9 and Fab-NP3B4 Mus sp.; Severe acute respiratory syndrome coronavirus 2 mus sp. mus sp. severe acute respiratory syndrome coronavirus2 Landeras-Bueno, S., Hariharan, C., Diaz Avalos, R., Ollmann Saphire, E. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV4 Kappa None None None None None 9c2h I J 0 D protein NA nucleoprotein VIRAL PROTEIN 05/14/25 SARS-CoV-2 Nucleocapsid Dimerization Domain bound to Fab-NP1E9 and Fab-NP3B4 Mus sp.; Severe acute respiratory syndrome coronavirus 2 mus sp. mus sp. severe acute respiratory syndrome coronavirus2 Landeras-Bueno, S., Hariharan, C., Diaz Avalos, R., Ollmann Saphire, E. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 9fns C D 0 A protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 Cryo-EM structure of the P domain of the Hepatitis E Virus ORF2 protein in complex with Fab ES1.327 Hepatitis E virus; Homo sapiens homo sapiens homo sapiens hepatitis e virus Baquero, E., Molinos, L., Mouquet, H. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9fns E F 0 B protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 Cryo-EM structure of the P domain of the Hepatitis E Virus ORF2 protein in complex with Fab ES1.327 Hepatitis E virus; Homo sapiens homo sapiens homo sapiens hepatitis e virus Baquero, E., Molinos, L., Mouquet, H. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9fnt C D 0 A protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 Cryo-EM structure of the P domain of the Hepatitis E Virus ORF2 protein in complex with Fab ES4.431 Homo sapiens homo sapiens homo sapiens homo sapiens Baquero, E., Molinos, L., Mouquet, H. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9fnt E F 0 B protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 Cryo-EM structure of the P domain of the Hepatitis E Virus ORF2 protein in complex with Fab ES4.431 Homo sapiens homo sapiens homo sapiens homo sapiens Baquero, E., Molinos, L., Mouquet, H. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9fq3 C D 0 B protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 HEV ORF2 protein in complex with Fabs Es1.114 and Es5.127 Hepatitis E virus; Homo sapiens homo sapiens homo sapiens hepatitis e virus Baquero, E., Molinos, L., Mouquet, H. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 9fq3 E F 0 A protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 HEV ORF2 protein in complex with Fabs Es1.114 and Es5.127 Hepatitis E virus; Homo sapiens homo sapiens homo sapiens hepatitis e virus Baquero, E., Molinos, L., Mouquet, H. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 9fq3 G H 0 B protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 HEV ORF2 protein in complex with Fabs Es1.114 and Es5.127 Hepatitis E virus; Homo sapiens homo sapiens homo sapiens hepatitis e virus Baquero, E., Molinos, L., Mouquet, H. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9fq3 I J 0 A protein NA secreted protein orf2 VIRAL PROTEIN 05/14/25 HEV ORF2 protein in complex with Fabs Es1.114 and Es5.127 Hepatitis E virus; Homo sapiens homo sapiens homo sapiens hepatitis e virus Baquero, E., Molinos, L., Mouquet, H. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ggp H L 0 A protein NA alpha-1-antitrypsin PROTEIN BINDING 05/14/25 Alpha-1-antitrypsin in complex with the Fab fragment of an anti-polymer antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lowen, S.M., Laffranchi, M., Lomas, D.A., Irving, J.A. 1.84 X-RAY DIFFRACTION 0.206 0.173 False True IGHV2 IGKV19 Kappa None None None None None 9gu0 F C 0 L protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in resting state in detergent with alpha-bungarotoxin Aequorea victoria; Bungarus multicinctus; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9gu0 H G 0 A protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in resting state in detergent with alpha-bungarotoxin Aequorea victoria; Bungarus multicinctus; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9gu1 F C 0 L protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in resting state in nanodisc with alpha-bungarotoxin Aequorea victoria; Bungarus multicinctus; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9gu1 H G 0 A protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in resting state in nanodisc with alpha-bungarotoxin Aequorea victoria; Bungarus multicinctus; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.48 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9gu2 F C 0 L protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in desensitised state in nanodisc with 100 uM acetylcholine Aequorea victoria; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9gu2 H G 0 A protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in desensitised state in nanodisc with 100 uM acetylcholine Aequorea victoria; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9gu3 F C 0 L protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in desensitised state in nanodisc with 1 mM acetylcholine Aequorea victoria; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9gu3 H G 0 A protein NA acetylcholine receptor subunit alpha MEMBRANE PROTEIN 05/14/25 Human adult muscle nAChR in desensitised state in nanodisc with 1 mM acetylcholine Aequorea victoria; Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Li, A., Pike, A.C.W., Chi, G., Webster, R., Maxwell, S., Liu, W., Beeson, D., Sauer, D.B., Dong, Y.Y. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV22 Kappa None None None None None 9nox E NA 0 B | C protein | protein NA | NA minigs/gust25 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/14/25 Transmembrane domains of the human TAS1R2 sweet receptor subunit in complex with miniGs/gust25 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Juen, Z., Lu, Z., Yu, R., Chang, A.N., Wang, B., Fitzpatrick, A.W.P., Zuker, C.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9o38 E NA 0 B | C protein | protein NA | NA taste receptor type 1 member 3,guanine nucleotide-bindingprotein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 HYDROLASE/IMMUNE SYSTEM 05/14/25 Transmembrane domains of the human sweet receptor (TAS1R2 + TAS1R3) from Class 3 particles (rigidly fitted from PDB:9NOX and 9NOR) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Juen, Z., Lu, Z., Yu, R., Chang, A.N., Wang, B., Fitzpatrick, A.W.P., Zuker, C.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9qub D C 0 A protein NA sodium/hydrogen exchanger 9b2 TRANSPORT PROTEIN 05/14/25 Cryo-EM structure of the human NHA2-Fab complex Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jung, S., Drew, D. 2.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9qub F E 0 B protein NA sodium/hydrogen exchanger 9b2 TRANSPORT PROTEIN 05/14/25 Cryo-EM structure of the human NHA2-Fab complex Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jung, S., Drew, D. 2.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9quw F E 0 B protein NA sodium/hydrogen exchanger 9b2 TRANSPORT PROTEIN 05/14/25 Cryo-EM structure of the human NHA2-Fab complex bound to phloretin Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jung, S., Drew, D. 2.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9quw D C 0 A protein NA sodium/hydrogen exchanger 9b2 TRANSPORT PROTEIN 05/14/25 Cryo-EM structure of the human NHA2-Fab complex bound to phloretin Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jung, S., Drew, D. 2.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 9r2e H L 0 P protein NA isoform 1 of immunoglobulin heavy constant alpha 1 IMMUNE SYSTEM 05/14/25 Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1 Homo sapiens homo sapiens homo sapiens homo sapiens Pannecoucke, E., Voet, S., Deweirdt, L., Verbeiren, J., Gabriels, S., Provost, M., Freier, R., Koenig, J., Lammens, A., Silence, K. 2.54 X-RAY DIFFRACTION 0.252 0.211 False True IGHV3 IGLV1 Lambda None None None None None 9r2e A B 0 Q protein NA isoform 1 of immunoglobulin heavy constant alpha 1 IMMUNE SYSTEM 05/14/25 Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1 Homo sapiens homo sapiens homo sapiens homo sapiens Pannecoucke, E., Voet, S., Deweirdt, L., Verbeiren, J., Gabriels, S., Provost, M., Freier, R., Koenig, J., Lammens, A., Silence, K. 2.54 X-RAY DIFFRACTION 0.252 0.211 False True IGHV3 IGLV1 Lambda None None None None None 8zca D A 0 F protein NA leukocyte surface antigen cd47 IMMUNE SYSTEM 05/07/25 Crystal structure of human CD47 ECD bound to Fab of Hu1C8 Homo sapiens homo sapiens homo sapiens homo sapiens Chen, Z., Ding, J. 2.5 X-RAY DIFFRACTION 0.266 0.215 False True IGHV3 IGKV1 Kappa None None None None None 8zca C B 0 E protein NA leukocyte surface antigen cd47 IMMUNE SYSTEM 05/07/25 Crystal structure of human CD47 ECD bound to Fab of Hu1C8 Homo sapiens homo sapiens homo sapiens homo sapiens Chen, Z., Ding, J. 2.5 X-RAY DIFFRACTION 0.266 0.215 False True IGHV3 IGKV1 Kappa None None None None None 9b7g H L 0 A protein NA hemagglutinin VIRAL PROTEIN 05/07/25 Cryo-EM structure of antibody TJ5-13 bound to H3 COBRA NG2 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dzimianski, J.V., Cruz, J.M., Serrao, V.H.B., DuBois, R.M. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9b7g J K 0 B protein NA hemagglutinin VIRAL PROTEIN 05/07/25 Cryo-EM structure of antibody TJ5-13 bound to H3 COBRA NG2 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dzimianski, J.V., Cruz, J.M., Serrao, V.H.B., DuBois, R.M. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9b7g Q P 0 C protein NA hemagglutinin VIRAL PROTEIN 05/07/25 Cryo-EM structure of antibody TJ5-13 bound to H3 COBRA NG2 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dzimianski, J.V., Cruz, J.M., Serrao, V.H.B., DuBois, R.M. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9bnk H L 0 F | E | G protein | protein | protein NA | NA | NA human immunodeficiency virus 1 envelope glycoprotein gp120 | human immunodeficiency virus 1 envelope glycoprotein gp120 | human immunodeficiency virus 1 envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/07/25 Cryo-EM structure of rhesus antibody V031-a.01 in complex with HIV-1 Env BG505 DS-SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV2 Kappa None None None None None 9bnl H L 0 A | E | C protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/07/25 Cryo-EM structure of rhesus antibody 6070-a.01 in complex with HIV-1 Env trimer Q23.17 MD39 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Shapiro, L., Kwong, P.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 9c0u H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/07/25 Crystal structure of chimeric hemagglutinin cH5/1 in complex with broad protective antibody 31.b.09 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Nguyen, T.K.Y., Zhu, X., Wilson, I.A. 3.59 X-RAY DIFFRACTION 0.344 0.294 False True IGHV1 IGKV2 Kappa None None None None None 9c0x H L 0 B | A protein | protein NA | NA hemagglutinin ha2 subunit | hemagglutinin ha1 subunit VIRAL PROTEIN/IMMUNE SYSTEM 05/07/25 Crystal structure of chimeric hemagglutinin cH11/1 in complex with broad protective antibody 31.b.09 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Nguyen, T.K.Y., Zhu, X., Wilson, I.A. 4.35 X-RAY DIFFRACTION 0.382 0.335 False True IGHV1 IGKV2 Kappa None None None None None 9cp5 H L 0 A protein NA sodium- and chloride-dependent gaba transporter 3 MEMBRANE PROTEIN 05/07/25 Cryo-EM structure of human GAT3, apo state, inward-open conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Yadav, R., Han, G.W., Gati, C. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9d0a E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha,guanine nucleotide-binding protein g(s) subunit alpha isoforms short chimera,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 05/07/25 CryoEM structure of PAR2 with endogenous tethered ligand. Homo sapiens; unidentified unidentified homo sapiens | homo sapiens Lyu, Z., Lyu, X., McGrath, A.P., Kang, Y. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9d4z E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alphachimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 05/07/25 CryoEM structure of PAR1 with endogenous tethered ligand Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Lyu, X., Lyu, Z., McGrath, A.P., Kang, Y. 2.74 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9gix C NA 0 B | A protein | protein NA | NA mitochondrial pyruvate carrier 2 | mitochondrial pyruvate carrier 1-like protein MEMBRANE PROTEIN 05/07/25 Structure of the human mitochondrial pyruvate carrier in the apo-state Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Sichrovsky, M., Lacabanne, D., Ruprecht, J.J., Rana, J.J., Stanik, K., Dionysopoulou, M., Sowton, A.P., King, M.S., Jones, S., Cooper, L., Hardwick, S.W., Paris, G., Chirgadze, D.Y., Ding, S., Fearnley, I.M., Palmer, S., Pardon, E., Steyaert, J., Leone, V., Forrest, L.R., Tavoulari, S., Kunji, E.R.S. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cb5 D H 0 B | C protein | nucleic-acid NA | NA nucleolin | myc promoter g-quadruplex TRANSCRIPTION/DNA 04/30/25 Crystal structure of nucleolin in complex with MYC promoter G-quadruplex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Chen, L., Dickerhoff, J., Noinaj, N., Yang, D. 2.6 X-RAY DIFFRACTION 0.254 0.232 False True IGHV3 IGKV1 Kappa None None None None None 9cb5 G I 0 A | F protein | nucleic-acid NA | NA nucleolin | myc promoter g-quadruplex TRANSCRIPTION/DNA 04/30/25 Crystal structure of nucleolin in complex with MYC promoter G-quadruplex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Chen, L., Dickerhoff, J., Noinaj, N., Yang, D. 2.6 X-RAY DIFFRACTION 0.254 0.232 False True IGHV3 IGKV1 Kappa None None None None None 9d8y G H 0 D | A protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with one gp120 rotated Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Thakur, B., Acharya, P. 4.06 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d8y I J 0 E | B protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with one gp120 rotated Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Thakur, B., Acharya, P. 4.06 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d8y K L 0 F | C protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with one gp120 rotated Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Thakur, B., Acharya, P. 4.06 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d98 G H 0 D | A protein | protein NA | NA transmembrane protein gp41 | surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with two gp120 protomers rotated Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Thakur, B., Acharya, P. 4.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d98 I J 0 E | B protein | protein NA | NA transmembrane protein gp41 | surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with two gp120 protomers rotated Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Thakur, B., Acharya, P. 4.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d98 K L 0 F | C protein | protein NA | NA transmembrane protein gp41 | surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with two gp120 protomers rotated Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Thakur, B., Acharya, P. 4.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8z8l A NA 0 B protein NA interleukin-4 receptor subunit alpha CYTOKINE 04/30/25 structure of IL-4Ra in complex with an nanobody 4E9 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Song, G., Qiu, W. 3.96 X-RAY DIFFRACTION 0.334 0.301 False True IGHV3 NA NA None None None None None 8zbi F f 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/30/25 Cryo-EM structure of Somatostatin receptor 3 (SSTR3) with Gi1 complex Homo sapiens homo sapiens homo sapiens | homo sapiens Yun, J.H. 2.79 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zbj F f 0 A | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/30/25 Cryo-EM structure of Somatostatin receptor 5 (SSTR5) with Gi1 complex Homo sapiens homo sapiens homo sapiens | homo sapiens Kim, Y., Yun, J.H. 2.94 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zym H D 0 A protein NA fusion glycoprotein f0,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Complex structure of 60 Fab bound to DS2 prefusion F trimer Mus musculus; Respiratory syncytial virus A2; synthetic construct mus musculus mus musculus respiratory syncytial virus a2, syntheticconstruct Wang, X., Ge, J., Guo, F. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV8 Kappa None None None None None 8zym I E 0 B protein NA fusion glycoprotein f0,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Complex structure of 60 Fab bound to DS2 prefusion F trimer Mus musculus; Respiratory syncytial virus A2; synthetic construct mus musculus mus musculus respiratory syncytial virus a2, syntheticconstruct Wang, X., Ge, J., Guo, F. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV8 Kappa None None None None None 8zym G F 0 C protein NA fusion glycoprotein f0,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Complex structure of 60 Fab bound to DS2 prefusion F trimer Mus musculus; Respiratory syncytial virus A2; synthetic construct mus musculus mus musculus respiratory syncytial virus a2, syntheticconstruct Wang, X., Ge, J., Guo, F. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV8 Kappa None None None None None 9d90 G H 0 D protein NA transmembrane protein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of partially open HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-17b Fab and 3-VRC34.01 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Thakur, B., Acharya, P. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d90 I J 0 E protein NA transmembrane protein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of partially open HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-17b Fab and 3-VRC34.01 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Thakur, B., Acharya, P. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d90 K L 0 F protein NA transmembrane protein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of partially open HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-17b Fab and 3-VRC34.01 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Thakur, B., Acharya, P. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9d90 Q P 0 C protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of partially open HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-17b Fab and 3-VRC34.01 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Thakur, B., Acharya, P. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9d90 S R 0 A protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of partially open HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-17b Fab and 3-VRC34.01 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Thakur, B., Acharya, P. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9d90 U T 0 B protein NA surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/30/25 Cryo-EM structure of partially open HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-17b Fab and 3-VRC34.01 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Thakur, B., Acharya, P. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9eci H L 0 NA NA NA NA IMMUNE SYSTEM 04/30/25 Crystal structure of a humanized 5E5 antibody synthetic construct synthetic construct synthetic construct Li, W., Evans, S.V. 1.57 X-RAY DIFFRACTION 0.183 0.156 False True IGHV1 IGKV4 Kappa None None None None None 9ego S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/30/25 Cannabinoid receptor 1-Gi complex with novel ligand Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Tummino, T.A., Iliopoulos-Tsoutsouvas, C., Braz, J.M., O'Brien, E.S., Krishna Kumar, K., Makriyannis, M., Basbaum, A.I., Shoichet, B.K. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9hy1 A a 0 NA NA NA NA IMMUNE SYSTEM 04/30/25 sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 7.5 (dimeric state from gel filtration) Mus musculus mus musculus Raucci, L., Orlandini, M., Pozzi, C. 1.81 X-RAY DIFFRACTION 0.196 0.169 True True unknown unknown unknown None None None None None 9hy2 A a 0 NA NA NA NA IMMUNE SYSTEM 04/30/25 sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 7.5 (monomeric state from gel filtration) Mus musculus mus musculus Raucci, L., Orlandini, M., Pozzi, C. 1.7 X-RAY DIFFRACTION 0.211 0.177 True True unknown unknown unknown None None None None None 9hy3 A a 0 NA NA NA NA IMMUNE SYSTEM 04/30/25 sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 5.5 Mus musculus mus musculus Raucci, L., Orlandini, M., Pozzi, C. 1.62 X-RAY DIFFRACTION 0.207 0.175 True True unknown unknown unknown None None None None None 9hy5 A a 0 NA NA NA NA IMMUNE SYSTEM 04/30/25 sc-4E (scFv derived from the mAb 4E1 against CD93) crystallized at pH 9.0 Mus musculus mus musculus Raucci, L., Orlandini, M., Pozzi, C. 1.6 X-RAY DIFFRACTION 0.200 0.167 True True unknown unknown unknown None None None None None 9ixv H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/30/25 Cryo-EM structure of MERS-CoV S1-NTD bound with KNIH-88 Fab Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Jeon, H., Yoo, Y., Park, K., Choi, K. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9f02 H L 0 A | C protein | protein NA | NA transmembrane protein gp41 | envelope glycoprotein gp160 VIRAL PROTEIN 04/23/25 HIV-1 envelope glycoprotein (BG505 gp140 SOSIP.664) trimer in complex with three copies of ELC07 broadly neutralizing antibody. Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Hope, J., Alguel, Y., Nans, A., Cherepanov, P. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9f02 I J 0 E | G protein | protein NA | NA transmembrane protein gp41 | envelope glycoprotein gp160 VIRAL PROTEIN 04/23/25 HIV-1 envelope glycoprotein (BG505 gp140 SOSIP.664) trimer in complex with three copies of ELC07 broadly neutralizing antibody. Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Hope, J., Alguel, Y., Nans, A., Cherepanov, P. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9f02 K M 0 F | N protein | protein NA | NA transmembrane protein gp41 | envelope glycoprotein gp160 VIRAL PROTEIN 04/23/25 HIV-1 envelope glycoprotein (BG505 gp140 SOSIP.664) trimer in complex with three copies of ELC07 broadly neutralizing antibody. Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Hope, J., Alguel, Y., Nans, A., Cherepanov, P. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9jh5 S s 0 A protein NA guanine nucleotide-binding protein g(i) subunit alpha-1 MEMBRANE PROTEIN 04/23/25 Activation mechanism of CYSLTR2 by C16:0 ceramide Homo sapiens; Lama glama; Mus musculus mus musculus homo sapiens Wang, J.L., Ding, J.H., Sun, J.P., Yu, X. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jh5 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/23/25 Activation mechanism of CYSLTR2 by C16:0 ceramide Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Wang, J.L., Ding, J.H., Sun, J.P., Yu, X. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8z2e H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/23/25 Crystal structure of nanobody Tnb04-1 with antibody 1F11 fab and SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.Q., Zhang, L.Q., Chen, J., Dong, H.D. 2.3 X-RAY DIFFRACTION 0.234 0.195 False True IGHV3 IGKV3 Kappa None None None None None 8z2e B NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/23/25 Crystal structure of nanobody Tnb04-1 with antibody 1F11 fab and SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, X.Q., Zhang, L.Q., Chen, J., Dong, H.D. 2.3 X-RAY DIFFRACTION 0.234 0.195 False True IGHV1 NA NA None None None None None 8z3m S s 0 A | B protein | protein NA | NA engineered g-alpha-q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of the hGPR4-Gq complex in pH6.5 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhong, Y.N., Guo, L.L., Yang, F., Sun, J.P. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8z3q S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of the hGPR4-Gs complex in pH7.6 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhong, Y.N., Guo, L.L., Yang, F., Sun, J.P. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8z4c H L 0 NA NA NA NA IMMUNE SYSTEM 04/23/25 The Fab fragment of anti-Fibrin monoclonal antibody 59D8 Mus musculus mus musculus mus musculus Zhang, J., Sun, C. 2.06 X-RAY DIFFRACTION 0.234 0.198 False True IGHV5 IGKV1 Kappa None None None None None 8z4c A D 0 NA NA NA NA IMMUNE SYSTEM 04/23/25 The Fab fragment of anti-Fibrin monoclonal antibody 59D8 Mus musculus mus musculus mus musculus Zhang, J., Sun, C. 2.06 X-RAY DIFFRACTION 0.234 0.198 False True IGHV5 IGKV1 Kappa None None None None None 8z65 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of the hGPR4-Gs complex in pH7.2 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhong, Y.N., Guo, L.L. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8z68 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of the hGPR68-Gs complex in pH6.8 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhong, Y.N., Guo, L.L., Yang, F., Sun, J.P. 2.64 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zce N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of GPR4 complexed with Gs in pH6.0 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zcf N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of GPR4 complexed with Gs in pH7.5 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9dpe H L 0 A protein NA butyrophilin subfamily 2 member a1 IMMUNE SYSTEM 04/23/25 CryoEM Structure of Human BTN2A1 ectodomain in complex with TCR-blocking 2A1.12 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ramesh, A., Fuller, J.R., Roy, S., Adams, E. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dpe N NA 0 NA NA NA NA IMMUNE SYSTEM 04/23/25 CryoEM Structure of Human BTN2A1 ectodomain in complex with TCR-blocking 2A1.12 Fab Homo sapiens homo sapiens Ramesh, A., Fuller, J.R., Roy, S., Adams, E. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hzj A NA 0 B protein NA circumsporozoite protein IMMUNE SYSTEM 04/23/25 sdAb1 in complex with PfCSP a-TSR domain Lama glama; Plasmodium falciparum NF54 lama glama plasmodium falciparum nf54 Sterckx, Y.G.-J., Geens, R. 2.06 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 9hzk A NA 0 B protein NA circumsporozoite protein IMMUNE SYSTEM 04/23/25 sdAb9 in complex with PfCSP aTSR domain Lama glama; Plasmodium falciparum NF54 lama glama plasmodium falciparum nf54 Sterckx, Y.G.-J., Geens, R. 2.07 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 NA NA None None None None None 9jfw N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of GPR4 complexed with Gs in pH6.8 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jfx N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of GPR4 complexed with miniGs/q in pH7.5 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jfz N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of intermediate state GPR4 complexed with miniGs/q in pH7.5 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jhp S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein subunit alpha-13 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of GPR4 complexed with miniG13 in pH6.8 Homo sapiens homo sapiens homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.35 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kef H L 0 A protein NA rabv-g VIRAL PROTEIN 04/23/25 Crystal strucutre of RABV-G in complex with SOJB-Fab complex Homo sapiens; Rabies virus CVS-11 homo sapiens homo sapiens rabies virus cvs-11 Lu, G., Yang, F., Lin, S. 3.4 X-RAY DIFFRACTION 0.264 0.217 False True IGHV2 IGLV3 Lambda None None None None None 9kep D A 0 B protein NA rabv-g-phd-fd VIRAL PROTEIN 04/23/25 RABV-G-PHD-FD/NM57-scFv Homo sapiens; Rabies virus CVS-11 homo sapiens homo sapiens rabies virus cvs-11 Lu, G., Yang, F., Keqing, Y., Lin, S. 2.89 X-RAY DIFFRACTION 0.281 0.233 True True IGHV1 IGLV2 Lambda None None None None None 9kfb A a 0 B protein NA rabv-g-ecto VIRAL PROTEIN 04/23/25 RABV-G-ecto/NM57-scFv complex Homo sapiens; Rabies virus CVS-11 homo sapiens rabies virus cvs-11 Lu, G., Yang, F., Lin, S. 4.3 X-RAY DIFFRACTION 0.314 0.261 True True unknown unknown unknown None None None None None 9kfb M m 0 K protein NA rabv-g-ecto VIRAL PROTEIN 04/23/25 RABV-G-ecto/NM57-scFv complex Homo sapiens; Rabies virus CVS-11 homo sapiens rabies virus cvs-11 Lu, G., Yang, F., Lin, S. 4.3 X-RAY DIFFRACTION 0.314 0.261 True True unknown unknown unknown None None None None None 9kfb X x 0 F protein NA rabv-g-ecto VIRAL PROTEIN 04/23/25 RABV-G-ecto/NM57-scFv complex Homo sapiens; Rabies virus CVS-11 homo sapiens rabies virus cvs-11 Lu, G., Yang, F., Lin, S. 4.3 X-RAY DIFFRACTION 0.314 0.261 True True unknown unknown unknown None None None None None 9lgm N NA 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN/IMMUNE SYSTEM 04/23/25 Cryo-EM structure of GPR4 complexed with Gs in pH8.0 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Yue, X.L., Wu, L.J., Hua, T., Liu, Z.J. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9m7v H L 0 C | B | A protein | protein | protein NA | NA | NA capsid protein vp3 | capsid protein vp2 | capsid protein vp1 VIRUS 04/23/25 Cryo-EM structure of enterovirus A71 mature virion in complex with Fab CT11F9 Enterovirus A71; Mus musculus mus musculus mus musculus enterovirus a71 | enterovirus a71 | enterovirus a71 Jiang, Y., Zhu, R., Zheng, Q., Li, S., Xia, N. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 8ult H L 0 E | B protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ult I M 0 A | D protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ult J N 0 C | F protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ulu K G 0 E protein NA envelope glycoprotein gp120 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 and PGDM1400 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True unknown IGKV2 Kappa None None None None None 8ulu H L 0 A | D protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 and PGDM1400 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ulu I M 0 E | B protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 and PGDM1400 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ulu J N 0 C | F protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 and PGDM1400 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 9bdo A NA 0 NA NA NA NA ANTITUMOR PROTEIN 04/16/25 Crystal structure of anti-abTCR NANOBODY VHH Lama glama lama glama Qiu, Y. 1.948 X-RAY DIFFRACTION 0.242 0.211 False True IGHV1 NA NA None None None None None 9bdo B NA 0 NA NA NA NA ANTITUMOR PROTEIN 04/16/25 Crystal structure of anti-abTCR NANOBODY VHH Lama glama lama glama Qiu, Y. 1.948 X-RAY DIFFRACTION 0.242 0.211 False True IGHV1 NA NA None None None None None 9bdo C NA 0 NA NA NA NA ANTITUMOR PROTEIN 04/16/25 Crystal structure of anti-abTCR NANOBODY VHH Lama glama lama glama Qiu, Y. 1.948 X-RAY DIFFRACTION 0.242 0.211 False True IGHV1 NA NA None None None None None 8rtf G NA 0 A protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 2.8 X-RAY DIFFRACTION 0.272 0.228 False True IGHV1 NA NA None None None None None 8rtf H NA 0 B protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 2.8 X-RAY DIFFRACTION 0.272 0.228 False True IGHV1 NA NA None None None None None 8rtf I NA 0 D protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 2.8 X-RAY DIFFRACTION 0.272 0.228 False True IGHV1 NA NA None None None None None 8rtf J NA 0 C protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 2.8 X-RAY DIFFRACTION 0.272 0.228 False True IGHV1 NA NA None None None None None 8rtf K NA 0 E protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 2.8 X-RAY DIFFRACTION 0.272 0.228 False True IGHV1 NA NA None None None None None 8rtf L NA 0 F protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 2.8 X-RAY DIFFRACTION 0.272 0.228 False True IGHV1 NA NA None None None None None 8rvr G NA 0 A protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) in the presence of sulfate Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 3.19 X-RAY DIFFRACTION 0.275 0.221 False True IGHV1 NA NA None None None None None 8rvr H NA 0 B protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) in the presence of sulfate Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 3.19 X-RAY DIFFRACTION 0.275 0.221 False True IGHV1 NA NA None None None None None 8rvr I NA 0 D protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) in the presence of sulfate Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 3.19 X-RAY DIFFRACTION 0.275 0.221 False True IGHV1 NA NA None None None None None 8rvr J NA 0 C protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) in the presence of sulfate Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 3.19 X-RAY DIFFRACTION 0.275 0.221 False True IGHV1 NA NA None None None None None 8rvr K NA 0 E protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) in the presence of sulfate Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 3.19 X-RAY DIFFRACTION 0.275 0.221 False True IGHV1 NA NA None None None None None 8rvr L NA 0 F protein NA pyruvate kinase TRANSFERASE 04/16/25 Crystal structure of Trypanosoma congolense pyruvate kinase in complex with a single-domain antibody (TcoPYK-sdAb42) in the presence of sulfate Trypanosoma congolense; Vicugna pacos vicugna pacos trypanosoma congolense Sterckx, Y.G.-J. 3.19 X-RAY DIFFRACTION 0.275 0.221 False True IGHV1 NA NA None None None None None 8uki H L 0 NA NA NA NA IMMUNE SYSTEM 04/16/25 Crystal structure of 04_A06 Fab Homo sapiens homo sapiens homo sapiens DeLaitsch, A.T., Gristick, H.B., Bjorkman, P.J. 1.75 X-RAY DIFFRACTION 0.205 0.170 False True unknown unknown unknown None None None None None 8ulr H L 0 E protein NA envelope glycoprotein gp160 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 05_B08 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8ulr I M 0 C protein NA envelope glycoprotein gp160 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 05_B08 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8ulr J N 0 A protein NA envelope glycoprotein gp160 Viral Protein/Immune System 04/16/25 Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 05_B08 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 DeLaitsch, A.T., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8z2v H L 0 A protein NA sonic hedgehog protein n-product IMMUNE SYSTEM 04/16/25 Crystal structure of Sonic hedgehog in complex with antibody 5E1 mutant H-R102A with metals Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Kaneda, I., Tsumoto, K. 1.89 X-RAY DIFFRACTION 0.225 0.186 False True IGHV1 IGKV6 Kappa None None None None None 8z39 H L 0 A protein NA sonic hedgehog protein n-product IMMUNE SYSTEM 04/16/25 Crystal structure of Sonic hedgehog in complex with antibody 5E1 mutant L-T56A with metals Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Kaneda, I., Tsumoto, K. 1.8 X-RAY DIFFRACTION 0.208 0.180 False True IGHV1 IGKV6 Kappa None None None None None 8z3a H L 0 A protein NA sonic hedgehog protein n-product IMMUNE SYSTEM 04/16/25 Crystal structure of Sonic hedgehog in complex with antibody 5E1 without metals Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Kaneda, I., Tsumoto, K. 1.75 X-RAY DIFFRACTION 0.207 0.175 False True IGHV1 IGKV6 Kappa None None None None None 8zyu D Q 0 B | R protein | protein NA | NA beta-arrestin-1 | soluble cytochrome b562,neurotensin receptor type 1 MEMBRANE PROTEIN 04/16/25 Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 1) Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | escherichia coli, homo sapiens Sun, D., Li, X., Yuan, Q., Yin, W., Xu, H.E., Tian, C. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9b6t H L 0 C | D | B | F protein | protein | protein | protein NA | NA | NA | NA capsid protein vp1 | capsid protein vp1 | capsid protein vp1 | capsid protein vp1 VIRAL PROTEIN/IMMUNE SYSTEM 04/16/25 Fab1-7 in complex with the capsid of Adeno-associated virus type 9 Adeno-associated virus; Homo sapiens homo sapiens homo sapiens adeno-associated virus | adeno-associated virus | adeno-associated virus | adeno-associated virus Mietzsch, M., McKenna, R. 2.54 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9b7p H L 0 C | B | D | F | A protein | protein | protein | protein | protein NA | NA | NA | NA | NA capsid protein vp1 | capsid protein vp1 | capsid protein vp1 | capsid protein vp1 | capsid protein vp1 VIRAL PROTEIN/IMMUNE SYSTEM 04/16/25 Fab2-6 in complex with the capsid of Adeno-associated virus type 9 Adeno-associated virus; Homo sapiens homo sapiens homo sapiens adeno-associated virus | adeno-associated virus | adeno-associated virus | adeno-associated virus | adeno-associated virus Mietzsch, M., McKenna, R. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9blb N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/16/25 Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in bypass conformation Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Wootten, D.L., Sexton, P.M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9blc N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/16/25 Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Wootten, D.L., Sexton, P.M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9blw N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/16/25 Human amylin1 Receptor in complex with Gs and Cagrilintide backbone (non-acylated) Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Sexton, P.M., Wootten, D.L. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9btw N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/16/25 Human Amylin3 Receptor in complex with Gs and cagrilintide Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Sexton, P.M., Wootten, D.L. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9bue N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/16/25 Human calcitonin Receptor in complex with Gs and cagrilintide in the CT-like conformation (repeat) Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Sexton, P.M., Wootten, D.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9cy1 B NA 0 A protein NA solute carrier organic anion transporter family member 1b1 TRANSPORT PROTEIN 04/16/25 Outward-facing OATP1B1 bound to sybody Sb5 Homo sapiens; synthetic construct synthetic construct homo sapiens Sung, M.W., Lees, J.A., Han, S. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cy3 B NA 0 A protein NA solute carrier organic anion transporter family member 1b1 TRANSPORT PROTEIN 04/16/25 Outward-facing Atorvastatin-bound OATP1B1 with sybody Sb5 Homo sapiens; synthetic construct synthetic construct homo sapiens Sung, M.W., Lees, J.A., Han, S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cy4 B NA 0 A protein NA solute carrier organic anion transporter family member 1b1 TRANSPORT PROTEIN 04/16/25 Outward-facing cyclosporine A-bound OATP1B1 with sybody 5 (Sb5) Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Sung, M.W., Lees, J.A., Han, S. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9dhy A B 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/16/25 Structure of SARS-CoV-2 spike in complex with antibody Fab COVIC-154 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yu, X., Saphire, E.O. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dhy D E 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/16/25 Structure of SARS-CoV-2 spike in complex with antibody Fab COVIC-154 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yu, X., Saphire, E.O. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dhy I J 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/16/25 Structure of SARS-CoV-2 spike in complex with antibody Fab COVIC-154 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yu, X., Saphire, E.O. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9evz H L 0 F | B | I protein | protein | protein NA | NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN 04/16/25 HIV-1 envelope glycoprotein (BG505 gp140 SOSIP.664) trimer in complex with ELC07 broadly neutralizing antibody. Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Hope, J., Alguel, Y., Nans, A., Cherepanov, P. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9kat A a 0 NA NA NA NA IMMUNE SYSTEM 04/16/25 Crystal structure of anti-sulfonylurea antibody scFv apo form Mus musculus mus musculus Yu, X.T., Gao, Y.G., Lei, H.T. 1.51 X-RAY DIFFRACTION 0.214 0.200 True True unknown unknown unknown None None None None None 9kat B b 0 NA NA NA NA IMMUNE SYSTEM 04/16/25 Crystal structure of anti-sulfonylurea antibody scFv apo form Mus musculus mus musculus Yu, X.T., Gao, Y.G., Lei, H.T. 1.51 X-RAY DIFFRACTION 0.214 0.200 True True unknown unknown unknown None None None None None 8tjr J K 0 F | C | D protein | protein | protein NA | NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp160 | envelope glycoprotein gp41 Viral Protein/Immune System 07/31/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-a.01 FAB Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Morano, N.C., Hoyt, F., Hansen, B., Fischer, E., Shapiro, L. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8tjr H L 0 E | B protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp160 Viral Protein/Immune System 07/31/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-a.01 FAB Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 | human immunodeficiency virus 1 Morano, N.C., Hoyt, F., Hansen, B., Fischer, E., Shapiro, L. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8tjs Q T 0 I | O protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp160 Viral PROTEIN/iMMUNE SYSTEM 07/31/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO GPZ6-a.01 FAB Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 | human immunodeficiency virus 1 Morano, N.C., Becker, J.E., Shapiro, L. 3.31 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8tjs P S 0 B protein NA envelope glycoprotein gp41 Viral PROTEIN/iMMUNE SYSTEM 07/31/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO GPZ6-a.01 FAB Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Morano, N.C., Becker, J.E., Shapiro, L. 3.31 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8tjs R U 0 H | N protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp160 Viral PROTEIN/iMMUNE SYSTEM 07/31/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO GPZ6-a.01 FAB Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 | human immunodeficiency virus 1 Morano, N.C., Becker, J.E., Shapiro, L. 3.31 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8tnu B C 0 Z | G protein | protein NA | NA transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Morano, N.C., Shapiro, L.S., Kwong, P.D. 3.36 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8tnu J K 0 X | F protein | protein NA | NA transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Morano, N.C., Shapiro, L.S., Kwong, P.D. 3.36 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8tnu H L 0 Y | E protein | protein NA | NA transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Morano, N.C., Shapiro, L.S., Kwong, P.D. 3.36 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8to7 H L 0 B | E protein | protein NA | NA transmembrane protein gp41 | surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Hoyt, F., Hansen, B., Fischer, E., Shapiro, L.S., Kwong, P.D. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8to7 G J 0 A | D protein | protein NA | NA transmembrane protein gp41 | surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Hoyt, F., Hansen, B., Fischer, E., Shapiro, L.S., Kwong, P.D. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8to7 I K 0 C | F protein | protein NA | NA transmembrane protein gp41 | surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Roark, R.S., Hoyt, F., Hansen, B., Fischer, E., Shapiro, L.S., Kwong, P.D. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8top H L 0 B | A protein | protein NA | NA hiv-1 bg505 ds-sosip glycoprotein gp41 | hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Zhou, T., Morano, N.C., Roark, R.S., Kwong, P.D. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8top J K 0 D | C protein | protein NA | NA hiv-1 bg505 ds-sosip glycoprotein gp41 | hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Zhou, T., Morano, N.C., Roark, R.S., Kwong, P.D. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8top M N 0 F | E protein | protein NA | NA hiv-1 bg505 ds-sosip glycoprotein gp41 | hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Zhou, T., Morano, N.C., Roark, R.S., Kwong, P.D. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8top U V 0 P | O protein | protein NA | NA hiv-1 bg505 ds-sosip glycoprotein gp41 | hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Zhou, T., Morano, N.C., Roark, R.S., Kwong, P.D. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8top W X 0 R | Q protein | protein NA | NA hiv-1 bg505 ds-sosip glycoprotein gp41 | hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Zhou, T., Morano, N.C., Roark, R.S., Kwong, P.D. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8top Y Z 0 T | S protein | protein NA | NA hiv-1 bg505 ds-sosip glycoprotein gp41 | hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Zhou, T., Morano, N.C., Roark, R.S., Kwong, P.D. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tq1 C D 0 F | A protein | protein NA | NA transmembrane protein gp41 | hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/07/24 HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3 Bos taurus; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Lee, W.H., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8tq1 M N 0 B | J protein | protein NA | NA transmembrane protein gp41 | hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/07/24 HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3 Bos taurus; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Lee, W.H., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8tq1 G I 0 K | E protein | protein NA | NA transmembrane protein gp41 | hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/Immune System 08/07/24 HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3 Bos taurus; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Lee, W.H., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8vfx M m 0 C | D protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN/DNA 08/07/24 Cryo-EM structure of 186bp ALBN1 nucleosome aided by scFv Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8vfx N n 0 G | H protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN/DNA 08/07/24 Cryo-EM structure of 186bp ALBN1 nucleosome aided by scFv Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhou, B.R., Bai, Y. 2.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8we4 H L 0 B protein NA spike protein s1 VIRUS/IMMUNE SYSTEM 07/24/24 SARS-CoV-2 Omicron XBB.1.5 RBD complexed with human ACE2 and S304 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, W., Xie, Y. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9b7b C D 0 A | B protein | protein NA | NA hla class ii histocompatibility antigen, dr alpha chain | hemagglutinin ha1 chain, hla class ii histocompatibilityantigen dr beta chain IMMUNE SYSTEM 08/07/24 Crystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA*01:01/HLA-DRB1*04:01) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Kassardjian, A., Julien, J.P. 3.08 X-RAY DIFFRACTION 0.237 0.200 False True IGHV4 IGKV1 Kappa None None None None None 9b7b G H 0 E | F protein | protein NA | NA hla class ii histocompatibility antigen, dr alpha chain | hemagglutinin ha1 chain, hla class ii histocompatibilityantigen dr beta chain IMMUNE SYSTEM 08/07/24 Crystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA*01:01/HLA-DRB1*04:01) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Kassardjian, A., Julien, J.P. 3.08 X-RAY DIFFRACTION 0.237 0.200 False True IGHV4 IGKV1 Kappa None None None None None 9cia B A 0 e protein NA unknown IMMUNE SYSTEM 07/31/24 T cell receptor complex Homo sapiens homo sapiens homo sapiens homo sapiens Gully, B.S., Rossjohn, J. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9cia D C 0 f protein NA unknown IMMUNE SYSTEM 07/31/24 T cell receptor complex Homo sapiens homo sapiens homo sapiens homo sapiens Gully, B.S., Rossjohn, J. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 9cmi H L 0 A | B protein | protein NA | NA claudin-4 | heat-labile enterotoxin b chain MEMBRANE PROTEIN 08/07/24 Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin, sFab COP-1, and Nanobody Clostridium perfringens; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | clostridium perfringens Vecchio, A.J. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cmi K NA 0 NA NA NA NA MEMBRANE PROTEIN 08/07/24 Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin, sFab COP-1, and Nanobody Clostridium perfringens; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens Vecchio, A.J. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y6k E e 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.34 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y6k J I 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8qxc H L 0 H Hapten X5X (2R,4S)-2-[(1R)-2-[[(5S)-5-acetamido-6-oxidanyl-6-oxidanylidene-hexyl]amino]-2-oxidanylidene-1-(2-phenylethanoylamino)ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid IMMUNE SYSTEM 07/31/24 Crystal structure of antibody Fab MIL-3 with PenG-Lys Mus musculus mus musculus mus musculus mus musculus Moynie, L., Naismith, J.H. 2.3 X-RAY DIFFRACTION 0.266 0.217 False True IGHV10 IGKV14 Kappa None None None None None 8qxc A B 0 A Hapten X5X (2R,4S)-2-[(1R)-2-[[(5S)-5-acetamido-6-oxidanyl-6-oxidanylidene-hexyl]amino]-2-oxidanylidene-1-(2-phenylethanoylamino)ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid IMMUNE SYSTEM 07/31/24 Crystal structure of antibody Fab MIL-3 with PenG-Lys Mus musculus mus musculus mus musculus mus musculus Moynie, L., Naismith, J.H. 2.3 X-RAY DIFFRACTION 0.266 0.217 False True IGHV10 IGKV14 Kappa None None None None None 8qxc C D 0 NA NA NA NA IMMUNE SYSTEM 07/31/24 Crystal structure of antibody Fab MIL-3 with PenG-Lys Mus musculus mus musculus mus musculus Moynie, L., Naismith, J.H. 2.3 X-RAY DIFFRACTION 0.266 0.217 False True IGHV10 IGKV14 Kappa None None None None None 8xwv H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 Structure of CXCR2 bound to CXCL1 (CXCR2-CXCL1-Go Full map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9crv K L 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-gamma2-beta2-alpha2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9fjk H L 0 A | B protein | protein NA | NA spike glycoprotein,fibritin | spike glycoprotein,fibritin VIRAL PROTEIN 08/14/24 Omicron BA.1 Spike protein with neutralizing NTD specific mAb K501SP6 Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 | severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Bjoernsson, K.H., Walker, M.R., Raghavan, S.S.R., Ward, A.B., Barfod, L.K. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9dmj F G 0 A | B protein | protein NA | NA acetylcholine receptor subunit alpha | acetylcholine receptor subunit epsilon MEMBRANE PROTEIN 04/09/25 Human muscle nAChR with two fab1b-bound Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Li, H., Hibbs, R.E. 2.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9dmj I H 0 C | D protein | protein NA | NA acetylcholine receptor subunit alpha | acetylcholine receptor subunit delta MEMBRANE PROTEIN 04/09/25 Human muscle nAChR with two fab1b-bound Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Li, H., Hibbs, R.E. 2.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8yyw B b 0 F | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/09/25 Cryo-EM structure of OXGR1 bound to alpha-ketoglutarate and Gq proteins Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Liu, A., Liu, Y. 3.16 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yyz H L 0 A protein NA sonic hedgehog protein n-product IMMUNE SYSTEM 04/09/25 Crystal structure of Sonic hedgehog in complex with antibody 5E1 mutant H-R102A in the absence of metals Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Senoo, A., Kaneda, I., Tsumoto, K. 1.9 X-RAY DIFFRACTION 0.222 0.184 False True IGHV1 IGKV6 Kappa None None None None None 9b6n H L 0 B | A | C protein | protein | protein NA | NA | NA capsid protein vp1 | capsid protein vp1 | capsid protein vp1 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 Fab1-1 in complex with the capsid of Adeno-associated virus type 9 Adeno-associated virus; Homo sapiens homo sapiens homo sapiens adeno-associated virus | adeno-associated virus | adeno-associated virus Mietzsch, M., McKenna, R. 3.31 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 9b88 A B 0 NA NA NA NA IMMUNE SYSTEM 04/09/25 Anti-OspC Fab 8C1 Homo sapiens homo sapiens homo sapiens Rudolph, M.J., Mantis, N. 1.73 X-RAY DIFFRACTION 0.176 0.151 False True IGHV1 IGKV1 Kappa None None None None None 9bof E C 0 B protein NA capsid protein vp1 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 16E10 Fab bound to norovirus GI.1 P domain Homo sapiens; Norovirus homo sapiens homo sapiens norovirus Olia, A.S., Morano, N.C., Shapiro, L., Kwong, P.D. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9bof G H 0 A protein NA capsid protein vp1 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 16E10 Fab bound to norovirus GI.1 P domain Homo sapiens; Norovirus homo sapiens homo sapiens norovirus Olia, A.S., Morano, N.C., Shapiro, L., Kwong, P.D. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9dao H L 0 B | A protein | protein NA | NA integrin beta-3 | integrin alpha-iib BLOOD CLOTTING 04/09/25 AlphaIIbbeta3 in fully-extended conformation in complex with R6H8 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Walz, T., Coller, B.S., Wang, J.L., Buitrago, L., Wang, L., Li, J.H. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV9 Kappa None None None None None 9dmk F G 0 A | B protein | protein NA | NA acetylcholine receptor subunit alpha | acetylcholine receptor subunit epsilon MEMBRANE PROTEIN 04/09/25 Human muscle nAChR with one fab1b-bound Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Li, H., Hibbs, R.E. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9dmq F G 0 D | C protein | protein NA | NA acetylcholine receptor subunit delta | acetylcholine receptor subunit alpha MEMBRANE PROTEIN 04/09/25 Human muscle nAChR with fab3-bound Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Li, H., Hibbs, R.E. 2.06 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9dms F G 0 E | B | A | D protein | protein | protein | protein NA | NA | NA | NA acetylcholine receptor subunit beta | acetylcholine receptor subunit epsilon | acetylcholine receptor subunit alpha | acetylcholine receptor subunit delta MEMBRANE PROTEIN 04/09/25 Human muscle nAChR with fab6-bound Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens | homo sapiens Li, H., Hibbs, R.E. 1.92 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9dmt F G 0 D | E | C protein | protein | protein NA | NA | NA acetylcholine receptor subunit delta | acetylcholine receptor subunit beta | acetylcholine receptor subunit alpha MEMBRANE PROTEIN 04/09/25 Human muscle nAChR with fab7-bound Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Li, H., Hibbs, R.E. 2.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dmv F G 0 E protein NA acetylcholine receptor subunit beta MEMBRANE PROTEIN 04/09/25 Human muscle nAChR with fab9-bound Homo sapiens homo sapiens homo sapiens homo sapiens Li, H., Hibbs, R.E. 2.13 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9ee8 E NA 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/09/25 GPCR A family receptor Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Bi, M., Wang, X., Ye, L., Cheng, Y. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ee9 E NA 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/09/25 GPCR A family receptor Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Bi, M., Wang, X., Ye, L., Cheng, Y. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9eea E NA 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/09/25 GPCR A family receptor Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Bi, M., Wang, X., Ye, L., Cheng, Y. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9fjf C NA 0 B protein NA lysosomal acid glucosylceramidase TRANSPORT PROTEIN 04/09/25 Lysosomal transporting complex of beta-glucocerebrosidase (GCase) and lysosomal integral membrane protein 2 (LIMP-2) with bound Pro-macrobodies (Combined focus map) Homo sapiens; synthetic construct synthetic construct homo sapiens Dobert, J.P., Schaefer, J.H.S., Dal Maso, T., Socher, E., Versees, W., Moeller, A., Zunke, F., Arnold, P. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fjf D NA 0 B protein NA lysosomal acid glucosylceramidase TRANSPORT PROTEIN 04/09/25 Lysosomal transporting complex of beta-glucocerebrosidase (GCase) and lysosomal integral membrane protein 2 (LIMP-2) with bound Pro-macrobodies (Combined focus map) Homo sapiens; synthetic construct synthetic construct homo sapiens Dobert, J.P., Schaefer, J.H.S., Dal Maso, T., Socher, E., Versees, W., Moeller, A., Zunke, F., Arnold, P. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9hml C NA 0 B protein NA kir2dl protein IMMUNE SYSTEM 04/09/25 KIR2DL1 bound to RIFIN PfKE01_040007400 Escherichia coli; Homo sapiens; Plasmodium falciparum homo sapiens Chamberlain, S.G., Higgins, M.K. 2.171 X-RAY DIFFRACTION 0.232 0.221 False True IGHV1 NA NA None None None None None 9jfy S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/09/25 Cryo-EM structure of Neuropeptide FF receptor 2 in complex with hNPSF and Gi Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Kim, J., Choi, H.-J. 3.21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jg0 H L 0 R protein NA isoform 2 of neuropeptide ff receptor 2,soluble cytochromeb562 MEMBRANE PROTEIN 04/09/25 Cryo-EM structure of neuropeptide FF receptor 2 in the ligand-free state with BRIL fusion, anti-BRIL Fab, and nanobody Escherichia coli; Homo sapiens; synthetic construct homo sapiens homo sapiens homo sapiens, escherichia coli Kim, J., Choi, H.-J. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9jg0 K NA 0 NA NA NA NA MEMBRANE PROTEIN 04/09/25 Cryo-EM structure of neuropeptide FF receptor 2 in the ligand-free state with BRIL fusion, anti-BRIL Fab, and nanobody Escherichia coli; Homo sapiens; synthetic construct synthetic construct Kim, J., Choi, H.-J. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9lyb N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 04/09/25 Cryo-EM structure of GPR3-G protein-monomer complex Homo sapiens homo sapiens homo sapiens | homo sapiens Hua, T., Liu, Z.J., Li, X.T., Chang, H. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9lyc N NA 0 C | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 04/09/25 Cryo-EM structure of GPR3-G protein-dimer complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Hua, T., Liu, Z.J., Li, X.T., Chang, H. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ua9 I F 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 1.99 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9ua9 H D 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 1.99 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9ua9 G E 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 1.99 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 9uaa G F 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 5C8 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 2.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9uaa H E 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 5C8 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 2.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9uaa I D 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/09/25 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 5C8 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 2.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8ywe B b 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 Local refinement of SARS-CoV-2 Omicron BA.2.86 S complexed with Abs G7-Fc Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens severe acute respiratory syndrome coronavirus Ma, Y., Liu, Q., Rehati, P., Zhang, Z. 2.69 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ywe C c 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 Local refinement of SARS-CoV-2 Omicron BA.2.86 S complexed with Abs G7-Fc Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens severe acute respiratory syndrome coronavirus Ma, Y., Liu, Q., Rehati, P., Zhang, Z. 2.69 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zu9 B A 0 E protein NA entry-fusion complex associated protein opg095 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 The complex structure of MPXV M1R and neutralizing antibody A129 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Ge, J.W. 2.17 X-RAY DIFFRACTION 0.262 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8zua A G 0 F protein NA entry-fusion complex associated protein opg095 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 The complex structure of MPXV M1R and neutralizing antibody A138 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Ge, J.W. 3.49 X-RAY DIFFRACTION 0.286 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8zua B D 0 C protein NA entry-fusion complex associated protein opg095 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 The complex structure of MPXV M1R and neutralizing antibody A138 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Ge, J.W. 3.49 X-RAY DIFFRACTION 0.286 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8zua E I 0 H protein NA entry-fusion complex associated protein opg095 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 The complex structure of MPXV M1R and neutralizing antibody A138 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Ge, J.W. 3.49 X-RAY DIFFRACTION 0.286 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8zua J L 0 K protein NA entry-fusion complex associated protein opg095 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 The complex structure of MPXV M1R and neutralizing antibody A138 Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus Ge, J.W. 3.49 X-RAY DIFFRACTION 0.286 0.237 False True IGHV3 IGKV1 Kappa None None None None None 9ary E e 0 B | C protein | protein NA | NA g subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/02/25 Global reconstruction 5-HT2AR bound to 5-HT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Fay, J.F., Roth, B.L. 3.27 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9as4 E e 0 B | C protein | protein NA | NA g subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/02/25 Global reconstruction of 5-HT2AR bound to LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Fay, J.F., Roth, B.L. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9as8 E e 0 B | C protein | protein NA | NA g subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/02/25 Global reconstruction of 5-HT2AR bound to psilocin in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM) Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Fay, J.F., Roth, B.L. 2.54 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9b7r H L 0 C | B | D | A | F protein | protein | protein | protein | protein NA | NA | NA | NA | NA capsid protein vp1 | capsid protein vp1 | capsid protein vp1 | capsid protein vp1 | capsid protein vp1 VIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 Fab3-1 in complex with the capsid of Adeno-associated virus type 9 Adeno-associated virus; Homo sapiens homo sapiens homo sapiens adeno-associated virus | adeno-associated virus | adeno-associated virus | adeno-associated virus | adeno-associated virus Mietzsch, M., McKenna, R. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9b7s H L 0 C | F | D | A protein | protein | protein | protein NA | NA | NA | NA capsid protein vp1 | capsid protein vp1 | capsid protein vp1 | capsid protein vp1 VIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 Fab3-2 in complex with the capsid of Adeno-associated virus type 9 Adeno-associated virus; Homo sapiens homo sapiens homo sapiens adeno-associated virus | adeno-associated virus | adeno-associated virus | adeno-associated virus Mietzsch, M., McKenna, R. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9e82 H L 0 A protein NA beta-arrestin-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/02/25 ACKR3 phosphorylated by GRK5 in complex with arrestin2 and Fab7 Bos taurus; Homo sapiens; synthetic construct synthetic construct synthetic construct bos taurus Chen, Q., Fuller, J., Tesmer, J.J.G. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9fik B C 0 A protein NA neurotrophin-3 IMMUNE SYSTEM 04/02/25 Structure of the FAB fragment of the Antibody NTF30037 in complex with NTF3 Homo sapiens homo sapiens homo sapiens homo sapiens Gallego, P., Aagaard, A., Sjogren, T., Chin, S., Neal, F. 1.86 X-RAY DIFFRACTION 0.186 0.186 False True IGHV3 IGLV3 Lambda None None None None None 9ixx E e 0 A | B protein | protein NA | NA g-alpha q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/02/25 Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4 Homo sapiens; Rattus norvegicus rattus norvegicus homo sapiens | homo sapiens Jiang, M., Xu, Y., Yin, W. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9izc S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/02/25 Cryo-EM structure of human HCAR2-Gi complex with MK1903 Homo sapiens homo sapiens homo sapiens | homo sapiens Xin, P., Fang, Y. 2.68 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9j8z S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/02/25 Cryo-EM structure of human HCAR1-Gi complex without ligand (apo state) Homo sapiens homo sapiens homo sapiens | homo sapiens Xin, P., Fang, Y. 3.36 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k6l S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 04/02/25 Cryo-EM structure of GPCR16-Gi2 complex Homo sapiens; Streptococcus pneumoniae; synthetic construct homo sapiens homo sapiens | homo sapiens Wang, X., Zhou, C., Wu, L.J., Hua, T., Liu, Z.J. 2.77 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kpd N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(t) subunit alpha- 3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/02/25 Cryo-EM structure of GPCR16-miniGs complex Homo sapiens; Streptococcus pneumoniae homo sapiens homo sapiens | homo sapiens Wang, X., Wu, L.J., Hua, T., Liu, Z.J. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9kpe S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/02/25 Cryo-EM structure of GPCR16-GiH5 complex Homo sapiens; Streptococcus pneumoniae homo sapiens homo sapiens | homo sapiens Wang, X., Wu, L.J., Hua, T., Liu, Z.J. 3.35 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kpf S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/02/25 Cryo-EM structure of GPCR16-Gi complex Homo sapiens; Streptococcus pneumoniae homo sapiens homo sapiens | homo sapiens Wang, X., Wu, L.J., Hua, T., Liu, Z.J. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9lbs A B 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 Cryo-EM structure of Omicron BA.1 RBD complexed with ConBA-998,S309 and S304Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z., Ju, B., Liu, C. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9lbs H L 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 Cryo-EM structure of Omicron BA.1 RBD complexed with ConBA-998,S309 and S304Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z., Ju, B., Liu, C. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9lbs D C 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/02/25 Cryo-EM structure of Omicron BA.1 RBD complexed with ConBA-998,S309 and S304Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z., Ju, B., Liu, C. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9lds A NA 0 B peptide NA spike protein s2' ANTIVIRAL PROTEIN 04/02/25 Crystal structure of nanobody H145 bound to SARS-CoV-2 spike stem-helix Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, G.W., Guo, L.Y., Lin, S. 1.6 X-RAY DIFFRACTION 0.202 0.191 False True IGHV1 NA NA None None None None None 9lds C NA 0 D peptide NA spike protein s2' ANTIVIRAL PROTEIN 04/02/25 Crystal structure of nanobody H145 bound to SARS-CoV-2 spike stem-helix Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, G.W., Guo, L.Y., Lin, S. 1.6 X-RAY DIFFRACTION 0.202 0.191 False True IGHV1 NA NA None None None None None 9lyo j i 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/02/25 Alpha SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kocharovskaya, M.V., Pichkur, E.B., Shenkarev, Z.O., Lyukmanova, E.N. 3.07 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 9lyo h g 0 C protein NA spike glycoprotein VIRAL PROTEIN 04/02/25 Alpha SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kocharovskaya, M.V., Pichkur, E.B., Shenkarev, Z.O., Lyukmanova, E.N. 3.07 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 9lyo n l 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/02/25 Alpha SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kocharovskaya, M.V., Pichkur, E.B., Shenkarev, Z.O., Lyukmanova, E.N. 3.07 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 9lyp j i 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/02/25 Alpha SARS-CoV-2 spike protein RBD-down in complex with REGN10987 Fab homologue (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kocharovskaya, M.V., Pichkur, E.B., Shenkarev, Z.O., Lyukmanova, E.N. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 9mfn H L 0 NA NA NA NA IMMUNE SYSTEM 04/02/25 Crystal Structure of ADI-64596 (human Fab, with substituted IgG1-CH1 (HC-L145Q, K147E, and S181E) and substituted kappa constant domain (LC-T129R, T178R, and T180Q)) Homo sapiens homo sapiens homo sapiens Battles, M.B., Welin, M., Laursen, M. 2.35 X-RAY DIFFRACTION 0.221 0.208 False True IGHV4 IGKV1 Kappa None None None None None 9mi7 H L 0 NA NA NA NA IMMUNE SYSTEM 04/02/25 Crystal Structure of ADI-64597 ((human Fab, with substituted IgG1-CH1 (HC-L128R and K147R) and substituted kappa constant domain (LC-Q124E, V133Q, and T178R)) Homo sapiens homo sapiens homo sapiens Battles, M.B., Welin, M., Laursen, M. 2.22 X-RAY DIFFRACTION 0.230 0.180 False True IGHV4 IGKV1 Kappa None None None None None 9ms8 H L 0 A protein NA protein patched homolog 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/02/25 PTCH1 in complex with Fab6H3 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hu, Q., Qi, X., Li, X. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8rew G F 0 A protein NA transforming growth factor beta-1 IMMUNE SYSTEM 03/26/25 CryoEM structure of human GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody. Homo sapiens; Lama glama lama glama lama glama homo sapiens Felix, J., Lambert, F., Marien, L., van der Woning, B., Savvides, S.N., Lucas, S. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 8rew H I 0 C protein NA transforming growth factor beta-1 IMMUNE SYSTEM 03/26/25 CryoEM structure of human GARP-lTGFbeta1 in complex with a Fab fragment derived from an activating antibody. Homo sapiens; Lama glama lama glama lama glama homo sapiens Felix, J., Lambert, F., Marien, L., van der Woning, B., Savvides, S.N., Lucas, S. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 8zyf H D 0 A protein NA spike protein s1 VIRAL PROTEIN 03/26/25 Crystal structure of ZW2G10 Fab in complex with omicron RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, H.Y., Li, J.M. 2.6 X-RAY DIFFRACTION 0.285 0.232 False True IGHV3 IGLV1 Lambda None None None None None 8zyf E C 0 B protein NA spike protein s1 VIRAL PROTEIN 03/26/25 Crystal structure of ZW2G10 Fab in complex with omicron RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, H.Y., Li, J.M. 2.6 X-RAY DIFFRACTION 0.285 0.232 False True IGHV3 IGLV1 Lambda None None None None None 9b0a A NA 0 D peptide NA cyclized peptide IMMUNE SYSTEM 03/26/25 GA10 nanobody bound to 2C7 peptide mimitope of Neisseria gonorrhoeae lipooligosaccharide synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct Williamson, A., Walker, E., Kelton, W., Hicks, J. 1.87 X-RAY DIFFRACTION 0.229 0.198 False True IGHV1 NA NA None None None None None 9b0a B NA 0 C peptide NA cyclized peptide IMMUNE SYSTEM 03/26/25 GA10 nanobody bound to 2C7 peptide mimitope of Neisseria gonorrhoeae lipooligosaccharide synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct Williamson, A., Walker, E., Kelton, W., Hicks, J. 1.87 X-RAY DIFFRACTION 0.229 0.198 False True IGHV1 NA NA None None None None None 9b13 H L 0 A protein NA 1-phosphatidylinositol 4,5-bisphosphate phosphodiesteraseepsilon-1 MEMBRANE PROTEIN 03/26/25 Cryo-EM structure of phospholipase Cepsilon PH-COOH in complex with an antigen-binding fragment (composite structure) Homo sapiens; Rattus norvegicus homo sapiens homo sapiens rattus norvegicus Samassekou, K., Lyon, A.M. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ebn N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/26/25 Peptide 1 (GLP-1 (Aib16, ACPC18)) bound to GLP-1R/Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Cary, B.P., Hager, M.V., Mariam, Z., Morris, R.K., Belousoff, M.J., Deganutti, G., Wootten, D., Sexton, P.M., Gellman, S.H. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ebo N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/26/25 Peptide 2 (GLP-1 (ACPC18)) bound to GLP-1R/Gs complex (conformer 1) Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cary, B.P., Hager, M.V., Mariam, Z., Morris, R.K., Belousoff, M.J., Deganutti, G., Wootten, D., Sexton, P.M., Gellman, S.H. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ebq N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/26/25 Peptide 2 (GLP-1 (ACPC18)) bound to GLP-1R/Gs complex (conformer 2) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Cary, B.P., Hager, M.V., Mariam, Z., Morris, R.K., Belousoff, M.J., Deganutti, G., Wootten, D., Sexton, P.M., Gellman, S.H. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9emy C NA 0 A protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9emy D NA 0 B protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9emy E NA 0 A protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9emy F NA 0 B protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9emy I NA 0 G protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9emy J NA 0 H protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9emy K NA 0 G protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9emy L NA 0 H protein NA non-specific serine/threonine protein kinase PEPTIDE BINDING PROTEIN 03/26/25 P. falciparum FIKK13 in complex with ATPgammaS Lama glama; Plasmodium falciparum lama glama plasmodium falciparum Purkiss, A.G., Ogrodowicz, R.W., Christodoulou, E., Kjaer, S. 2.814 X-RAY DIFFRACTION 0.286 0.242 False True IGHV1 NA NA None None None None None 9ds2 G I 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chai VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Crystal structure of 346-54 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Lin, T.H., Wilson, I.A. 3.29 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGKV3 Kappa None None None None None 9ds2 H J 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chai VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Crystal structure of 346-54 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Lin, T.H., Wilson, I.A. 3.29 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGKV3 Kappa None None None None None 9ds2 K L 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chai VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Crystal structure of 346-54 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Lin, T.H., Wilson, I.A. 3.29 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGKV3 Kappa None None None None None 8uhh H L 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.elbow.20.N32F Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.84 X-RAY DIFFRACTION 0.236 0.204 False True IGHV1 IGKV1 Kappa None None None None None 8uhj H L 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20.N32F Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.94 X-RAY DIFFRACTION 0.247 0.218 False True IGHV1 IGKV1 Kappa None None None None None 8uhn H L 0 D peptide NA 3phis peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20.N32F with 3pHis peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 2.09 X-RAY DIFFRACTION 0.245 0.218 False True IGHV1 IGKV1 Kappa None None None None None 8uhn A B 0 C peptide NA 3phis peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20.N32F with 3pHis peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 2.09 X-RAY DIFFRACTION 0.245 0.218 False True IGHV1 IGKV1 Kappa None None None None None 8uhp H L 0 C peptide NA 3ptza peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20.N32F with 3pTZA peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.98 X-RAY DIFFRACTION 0.247 0.216 False True IGHV1 IGKV1 Kappa None None None None None 8uhp B A 0 D peptide NA 3ptza peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20.N32F with 3pTZA peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.98 X-RAY DIFFRACTION 0.247 0.216 False True IGHV1 IGKV1 Kappa None None None None None 8uhs H L 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20.elbow bound to phosphate Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.286 0.252 False True IGHV1 IGKV1 Kappa None None None None None 8uht H L 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20.elbow bound to Glu H1 Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.290 0.244 False True IGHV1 IGKV1 Kappa None None None None None 8uig H L 0 C peptide NA 3phis peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20 with 3pHis peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.213 0.172 False True IGHV1 IGKV1 Kappa None None None None None 8uih H L 0 D peptide NA 3ptza peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck.20 with 3pTza peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.243 0.205 False True IGHV1 IGKV1 Kappa None None None None None 8uio H L 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.239 0.210 False True IGHV1 IGKV1 Kappa None None None None None 8uio A B 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.239 0.210 False True IGHV1 IGKV1 Kappa None None None None None 8uit H L 0 C peptide NA 3phis peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck with 3pHis peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.275 0.230 False True IGHV1 IGKV1 Kappa None None None None None 8uit A B 0 D peptide NA 3phis peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck with 3pHis peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.275 0.230 False True IGHV1 IGKV1 Kappa None None None None None 8uji H L 0 D peptide NA 3-ptza peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck with 3pTza peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.95 X-RAY DIFFRACTION 0.260 0.212 False True IGHV1 IGKV1 Kappa None None None None None 8uji A B 0 C peptide NA 3-ptza peptide IMMUNE SYSTEM 03/19/25 anti-Phosphohistidine Fab hSC44.ck with 3pTza peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Hunter, T., Wilson, I.A. 1.95 X-RAY DIFFRACTION 0.260 0.212 False True IGHV1 IGKV1 Kappa None None None None None 8uzp H L 0 M protein NA stem_mimetic_01 IMMUNE SYSTEM 03/19/25 Crystal Structure of the Computationally Designed Influenza Hemagglutinin Epitope Scaffold stem_mimetic_01 bound by Antibody CR9501 Homo sapiens; Mus musculus homo sapiens homo sapiens mus musculus Harshbarger, W., Malito, E. 2.711 X-RAY DIFFRACTION 0.246 0.199 False True IGHV1 IGLV1 Lambda None None None None None 8uzp A B 0 E protein NA stem_mimetic_01 IMMUNE SYSTEM 03/19/25 Crystal Structure of the Computationally Designed Influenza Hemagglutinin Epitope Scaffold stem_mimetic_01 bound by Antibody CR9501 Homo sapiens; Mus musculus homo sapiens homo sapiens mus musculus Harshbarger, W., Malito, E. 2.711 X-RAY DIFFRACTION 0.246 0.199 False True IGHV1 IGLV1 Lambda None None None None None 8veb G I 0 E protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8veb H L 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8veb J K 0 C protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8ved H L 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E11 in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8ved G I 0 C protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E11 in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8ved J K 0 E protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E11 in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8vee H L 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 in complex with H7N9 Influenza Hemagglutinin Trimer (A/Shanghai/2/13) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Casner, R.G., Shapiro, L. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vee G I 0 C protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 in complex with H7N9 Influenza Hemagglutinin Trimer (A/Shanghai/2/13) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Casner, R.G., Shapiro, L. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vee J K 0 E protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 in complex with H7N9 Influenza Hemagglutinin Trimer (A/Shanghai/2/13) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Casner, R.G., Shapiro, L. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vef H L 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 UCA (unmutated common ancestor) in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vef J K 0 C protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 UCA (unmutated common ancestor) in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vef G I 0 E protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 03/19/25 Cryo-EM structure of antibody T5-1E08 UCA (unmutated common ancestor) in complex with stabilized H1N1 Influenza Hemagglutinin Trimer (A/Kiev/1/57) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Cerutti, G., Shapiro, L. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vpf M N 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of SARS-CoV spike in complex with CoV1-65 Fab (NTD-bound) Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Bangaru, S., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8vpf D F 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of SARS-CoV spike in complex with CoV1-65 Fab (NTD-bound) Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Bangaru, S., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8vpf E G 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of SARS-CoV spike in complex with CoV1-65 Fab (NTD-bound) Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Bangaru, S., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8w8w N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/19/25 Cryo-EM structure of alpha-MSH-MC3R-Gs_Nb35 complex Bos taurus; Escherichia coli; Homo sapiens; Lama glama; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus norvegicus Chen, Q., Fu, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8w8x N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/19/25 Cryo-EM structure of beta-MSH-MC3R-Gs_Nb35 complex Bos taurus; Escherichia coli; Homo sapiens; Lama glama; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus norvegicus Chen, Q., Fu, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8w8y N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/19/25 Cryo-EM structure of gamma-MSH-MC3R-Gs_Nb35 complex Bos taurus; Escherichia coli; Homo sapiens; Lama glama; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus norvegicus Chen, Q., Fu, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9b5y N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/19/25 Cryo-EM structure of the LAPTH-bound PTH1R in complex with Gq Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, X., Liu, H., Zhang, C., Vilardaga, J.-P. 3.49 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9dpc H L 0 D protein NA neuraminidase IMMUNE SYSTEM 03/19/25 Structure of Fab 297 in complex with influenza H1N1 A/Victoria/4897/2022 neuraminidase Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Pholcharee, T., Wu, N.C. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9dru H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Crystal structure of 04709_4F04 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Lin, T.H., Wilson, I.A. 2.75 X-RAY DIFFRACTION 0.265 0.212 False True IGHV3 IGKV3 Kappa None None None None None 9ds1 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chai VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Crystal structure of 241_2F04 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Lin, T.H., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.263 0.220 False True IGHV3 IGKV3 Kappa None None None None None 9dsc A F 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 Crystal structure of Apo-241_2F04-A95a mutant Fab Homo sapiens homo sapiens homo sapiens Lin, T.H., Wilson, I.A. 2.01 X-RAY DIFFRACTION 0.236 0.200 False True IGHV3 IGKV3 Kappa None None None None None 9dsc B C 0 NA NA NA NA IMMUNE SYSTEM 03/19/25 Crystal structure of Apo-241_2F04-A95a mutant Fab Homo sapiens homo sapiens homo sapiens Lin, T.H., Wilson, I.A. 2.01 X-RAY DIFFRACTION 0.236 0.200 False True IGHV3 IGKV3 Kappa None None None None None 9fr3 C NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fr3 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fr3 F NA 0 D protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fr3 I NA 0 G protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fr3 K NA 0 H protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fr3 L NA 0 J protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fr4 A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F (local refinement) Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fr4 C NA 0 D protein NA spike glycoprotein VIRAL PROTEIN 03/19/25 Structure of the SARS-CoV-2 spike glycoprotein in complex with nanobody 7F (local refinement) Lama glama; Severe acute respiratory syndrome coronavirus lama glama severe acute respiratory syndrome coronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9h1f B NA 0 A protein NA cofilin-1 PROTEIN BINDING 03/19/25 Cofilin-1 in complex with high-affinity Sybody B12 Homo sapiens; synthetic construct synthetic construct homo sapiens Paraschiakos, T., Windhorst, S., Pogenberg, V. 1.8 X-RAY DIFFRACTION 0.226 0.203 False True IGHV1 NA NA None None None None None 9j3j B NA 0 A protein NA adp,atp carrier protein 1, chloroplastic MEMBRANE PROTEIN 03/19/25 Arabidopsis ATP/ADP translocator AtNTT1 Arabidopsis thaliana; Vicugna pacos vicugna pacos arabidopsis thaliana Lin, H.J., Huang, J., Li, T.M., Li, W.J., Su, N.N., Zhang, J.R., Wu, X.D., Fan, M.R. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9j3l C NA 0 A protein NA adp,atp carrier protein 1, chloroplastic MEMBRANE PROTEIN 03/19/25 ATP bound Arabidopsis ATP/ADP translocator AtNTT1 Arabidopsis thaliana; Vicugna pacos vicugna pacos arabidopsis thaliana Lin, H.J., Huang, J., Li, T.M., Li, W.J., Su, N.N., Zhang, J.R., Wu, X.D., Fan, M.R. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9j3m B NA 0 A protein NA adp,atp carrier protein 1, chloroplastic MEMBRANE PROTEIN 03/19/25 ADP/Pi bound Arabidopsis ATP/ADP translocator AtNTT1 Arabidopsis thaliana; Vicugna pacos vicugna pacos arabidopsis thaliana Lin, H.J., Huang, J., Li, T.M., Li, W.J., Su, N.N., Zhang, J.R., Wu, X.D., Fan, M.R. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9j3n B NA 0 A protein NA adp,atp carrier protein 1 MEMBRANE PROTEIN 03/19/25 ATP bound Chlamydia pneumoniae ATP/ADP translocator NTT1(Inward open state) Chlamydia pneumoniae; Vicugna pacos vicugna pacos chlamydia pneumoniae Lin, H.J., Huang, J., Li, T.M., Li, W.J., Su, N.N., Zhang, J.R., Wu, X.D., Fan, M.R. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9j3o B NA 0 A protein NA adp,atp carrier protein 1 MEMBRANE PROTEIN 03/19/25 Chlamydia pneumoniae ATP/ADP translocator NTT1(Outward open state) Chlamydia pneumoniae; Vicugna pacos vicugna pacos chlamydia pneumoniae Lin, H.J., Huang, J., Li, T.M., Li, W.J., Su, N.N., Zhang, J.R., Wu, X.D., Fan, M.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9jhj E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/19/25 Cryo-EM structure of the C18:0 ceramide-bound FPR2-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Sun, J.P., Jiang, C.T., Kong, W., Yu, X., Cai, K., Guo, L.L. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9l6c A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Cryo-EM structure of Delta RBD complexed with ConD-852, P2C-1F11 and S304 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Z., Bing, J., Congcong, L., Bing, Z. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9l6c H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Cryo-EM structure of Delta RBD complexed with ConD-852, P2C-1F11 and S304 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Z., Bing, J., Congcong, L., Bing, Z. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9l6c D F 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Cryo-EM structure of Delta RBD complexed with ConD-852, P2C-1F11 and S304 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Z., Bing, J., Congcong, L., Bing, Z. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9mer H L 0 B protein NA h1h5 ha VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Structure of H1H5:FluA20 Chimeric Influenza HA Complex Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seraj, N. 2 X-RAY DIFFRACTION 0.215 0.206 False True IGHV4 IGKV1 Kappa None None None None None 9mev H L 0 B protein NA h1h3 ha VIRAL PROTEIN/IMMUNE SYSTEM 03/19/25 Structure of H1H3:FluA20 Chimeric Antigen Complex Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seraj, N. 2.06 X-RAY DIFFRACTION 0.209 0.181 False True IGHV4 IGKV1 Kappa None None None None None 9myl H L 0 C protein NA izumo sperm-egg fusion protein 1 CELL ADHESION 03/19/25 Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-sperm Antibody OBF13 Mus musculus mus musculus mus musculus mus musculus Tang, S. 3.177 X-RAY DIFFRACTION 0.263 0.212 False True IGHV14 IGKV6 Kappa None None None None None 9myl A B 0 D protein NA izumo sperm-egg fusion protein 1 CELL ADHESION 03/19/25 Fertilization IZUMO1 Protein Ectodomain in Complex with Anti-sperm Antibody OBF13 Mus musculus mus musculus mus musculus mus musculus Tang, S. 3.177 X-RAY DIFFRACTION 0.263 0.212 False True IGHV14 IGKV6 Kappa None None None None None 8rmx E F 0 D protein NA protein-glutamine gamma-glutamyltransferase e TRANSFERASE 03/12/25 Transglutaminase 3 in complex with DH patient-derived Fab DH63-A02 Homo sapiens homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 2.803 X-RAY DIFFRACTION 0.250 0.205 False True IGHV2 IGKV4 Kappa None None None None None 8rmx B C 0 A protein NA protein-glutamine gamma-glutamyltransferase e TRANSFERASE 03/12/25 Transglutaminase 3 in complex with DH patient-derived Fab DH63-A02 Homo sapiens homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 2.803 X-RAY DIFFRACTION 0.250 0.205 False True IGHV2 IGKV4 Kappa None None None None None 8rmy E F 0 D protein NA protein-glutamine gamma-glutamyltransferase e TRANSFERASE 03/12/25 Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-A02 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 2.9 X-RAY DIFFRACTION 0.243 0.195 False True IGHV2 IGKV4 Kappa None None None None None 8rmy B C 0 A protein NA protein-glutamine gamma-glutamyltransferase e TRANSFERASE 03/12/25 Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-A02 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 2.9 X-RAY DIFFRACTION 0.243 0.195 False True IGHV2 IGKV4 Kappa None None None None None 8u1p H L 0 A protein NA gametocyte surface protein p45/48 CELL INVASION/Immune System 03/12/25 Local refinement of Plasmodium falciparum gametocyte surface protein Pfs48/45 Domains 1 and 2 in complex with neutralizing antibodies Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Kucharska, I., Hailemariam, S., Ivanochko, D., Rubinstein, J., Julien, J.P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8u1p B C 0 A protein NA gametocyte surface protein p45/48 CELL INVASION/Immune System 03/12/25 Local refinement of Plasmodium falciparum gametocyte surface protein Pfs48/45 Domains 1 and 2 in complex with neutralizing antibodies Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Kucharska, I., Hailemariam, S., Ivanochko, D., Rubinstein, J., Julien, J.P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8yk4 A a 0 C protein NA spike protein s1 VIRAL PROTEIN 03/12/25 Structure of SARS-CoV-2 RBD and antibody NT-108 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Anraku, Y., Kita, S., Onodera, T., Sato, A., Tadokoro, T., Adachi, Y., Ito, S., Suzuki, T., Sasaki, J., Shiwa, N., Iwata, N., Nagata, N., Kazuki, Y., Oshimura, M., Sasaki, M., Orba, Y., Suzuki, T., Sawa, H., Hashiguchi, T., Fukuhara, H., Takahashi, Y., Maenaka, K. 3.2 X-RAY DIFFRACTION 0.267 0.243 True True unknown unknown unknown None None None None None 8ykg D d 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/12/25 Structure of SARS-CoV-2 spike glycoprotein in complex with NT-108 scFv (1-up state) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Anraku, Y., Kita, S., Onodera, T., Tadokoro, T., Ito, S., Adachi, Y., Kotaki, R., Suzuki, T., Hashiguchi, T., Takahashi, Y., Maenaka, K. 3.28 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ykg F f 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/12/25 Structure of SARS-CoV-2 spike glycoprotein in complex with NT-108 scFv (1-up state) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Anraku, Y., Kita, S., Onodera, T., Tadokoro, T., Ito, S., Adachi, Y., Kotaki, R., Suzuki, T., Hashiguchi, T., Takahashi, Y., Maenaka, K. 3.28 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ykh A a 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/12/25 Structure of SARS-CoV-2 spike RBD in complex with NT-108 scFv Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Anraku, Y., Kita, S., Onodera, T., Tadokoro, T., Ito, S., Adachi, Y., Kotaki, R., Suzuki, T., Hashiguchi, T., Takahashi, Y., Maenaka, K. 3.27 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ykt H L 0 A protein NA enterotoxin type b PROTEIN BINDING/IMMUNE SYSTEM 03/12/25 Fab and SEB complex Homo sapiens; Staphylococcus aureus homo sapiens homo sapiens staphylococcus aureus Zeng, H., Fan, H.Y. 2.04 X-RAY DIFFRACTION 0.230 0.195 False True IGHV3 IGLV1 Lambda None None None None None 8yw6 C NA 0 B protein NA mitochondrial pyruvate carrier 2 PROTEIN TRANSPORT 03/12/25 Cryo-EM structure of apo human mitochondrial pyruvate carrier in the IMS-open conformation at pH 8.0 Homo sapiens; synthetic construct synthetic construct homo sapiens Shi, J.H., Liang, J.M., Ma, D. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8yw8 C NA 0 B protein NA mitochondrial pyruvate carrier 2 PROTEIN TRANSPORT 03/12/25 Cryo-EM structure of human mitochondrial pyruvate carrier in complex with the inhibitor UK5099 Escherichia coli BL21(DE3); Homo sapiens escherichia coli bl21(de3) homo sapiens Shi, J.H., Liang, J.M., Ma, D. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8yw9 C NA 0 A protein NA mitochondrial pyruvate carrier 1 PROTEIN TRANSPORT 03/12/25 Cryo-EM structure of human mitochondrial pyruvate carrier in the matrix-facing conformation at pH 6.8 Escherichia coli BL21(DE3); Homo sapiens escherichia coli bl21(de3) homo sapiens Shi, J.H., Liang, J.M., Ma, D. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8yw9 D NA 0 B protein NA mitochondrial pyruvate carrier 2 PROTEIN TRANSPORT 03/12/25 Cryo-EM structure of human mitochondrial pyruvate carrier in the matrix-facing conformation at pH 6.8 Escherichia coli BL21(DE3); Homo sapiens escherichia coli bl21(de3) homo sapiens Shi, J.H., Liang, J.M., Ma, D. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9azr H L 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 03/12/25 Lineage 860 UCA Fab bound to A/Massachusetts/1/1990 hemagglutinin head Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Maurer, D.P., Schmidt, A.G. 2.3 X-RAY DIFFRACTION 0.270 0.229 False True IGHV1 IGLV3 Lambda None None None None None 9azt H L 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 03/12/25 CH67 Fab bound to A/Massachusetts/1/1990 influenza hemagglutinin head with a G189E mutation (1) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Maurer, D.P., Schmidt, A.G. 2.94 X-RAY DIFFRACTION 0.338 0.294 False True IGHV1 IGLV3 Lambda None None None None None 9azv H L 0 E protein NA hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 03/12/25 CH67 Fab bound to A/Massachusetts/1/1990 influenza hemagglutinin head with a G189E mutation (2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Maurer, D.P., Schmidt, A.G. 3.16 X-RAY DIFFRACTION 0.287 0.237 False True IGHV1 IGLV3 Lambda None None None None None 9bjg H L 0 A protein NA apical membrane antigen 1 STRUCTURAL PROTEIN 03/12/25 Crystal structure of broadly neutralizing human monoclonal antibody 75B10 in complex with AMA1 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Patel, P.N., Tang, W.K., Tolia, N.H. 2.9 X-RAY DIFFRACTION 0.232 0.199 False True IGHV3 IGKV1 Kappa None None None None None 9bjh H L 0 A protein NA apical membrane antigen 1 STRUCTURAL PROTEIN 03/12/25 Crystal structure of neutralizing human monoclonal antibody 75C8 in complex with AMA1 DI-DII Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Patel, P.N., Tang, W.K., Tolia, N.H. 2.8 X-RAY DIFFRACTION 0.253 0.211 False True IGHV4 IGKV3 Kappa None None None None None 9bjh I M 0 B protein NA apical membrane antigen 1 STRUCTURAL PROTEIN 03/12/25 Crystal structure of neutralizing human monoclonal antibody 75C8 in complex with AMA1 DI-DII Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Patel, P.N., Tang, W.K., Tolia, N.H. 2.8 X-RAY DIFFRACTION 0.253 0.211 False True IGHV4 IGKV3 Kappa None None None None None 9bll H L 0 T protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/12/25 Cryo-EM of RBD(EG5.1)/1301B7 Fab Complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Walter, M.R., Green, T.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9cci B C 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/12/25 Dissecting human monoclonal antibody responses from mRNA and protein-based booster vaccinations against XBB1.5 SARS-CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Bajic, G., Jaiswal, D. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 9ccj H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/12/25 Dissecting human monoclonal antibody responses from mRNA and protein-based booster vaccinations against XBB1.5 SARS-CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Bajic, G., Civljak, A. 2.37 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9dry E F 0 A protein NA e3 ubiquitin-protein ligase chip LIGASE/IMMUNE SYSTEM 03/12/25 CHIP U-box dimer bound to Fab 2F1 Homo sapiens homo sapiens homo sapiens homo sapiens Unnikrishnan, A., Southworth, D. 7.02 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV10 Lambda None None None None None 9dry G H 0 B protein NA e3 ubiquitin-protein ligase chip LIGASE/IMMUNE SYSTEM 03/12/25 CHIP U-box dimer bound to Fab 2F1 Homo sapiens homo sapiens homo sapiens homo sapiens Unnikrishnan, A., Southworth, D. 7.02 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV10 Lambda None None None None None 9goe B NA 0 A protein NA phosphatidylglycerol lysyltransferase MEMBRANE PROTEIN 03/12/25 Cryo-EM structure of the multiple peptide resistance factor (MprF) from Pseudomonas aeruginosa bound to a synthetic nanobody (Sb29) Pseudomonas aeruginosa PAO1; synthetic construct synthetic construct pseudomonas aeruginosa pao1 Hankins, M.T.K., Parrag, M., Garaeva, A.A., Earp, J.C., Seeger, M.A., Stansfeld, P.J., Bublitz, M. 3.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9h4r H L 0 A protein NA zona pellucida sperm-binding protein 2 CELL ADHESION 03/12/25 Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form I) Mus musculus; Rattus norvegicus rattus norvegicus rattus norvegicus mus musculus Dioguardi, E., De Sanctis, D., Jovine, L. 1.53 X-RAY DIFFRACTION 0.233 0.206 False True IGHV1 IGKV8 Kappa None None None None None 9h4r X Y 0 B protein NA zona pellucida sperm-binding protein 2 CELL ADHESION 03/12/25 Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form I) Mus musculus; Rattus norvegicus rattus norvegicus rattus norvegicus mus musculus Dioguardi, E., De Sanctis, D., Jovine, L. 1.53 X-RAY DIFFRACTION 0.233 0.206 False True IGHV1 IGKV8 Kappa None None None None None 9h4s H L 0 A protein NA zona pellucida sperm-binding protein 2 CELL ADHESION 03/12/25 Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form II) Mus musculus; Rattus norvegicus rattus norvegicus rattus norvegicus mus musculus Dioguardi, E., De Sanctis, D., Jovine, L. 2.02 X-RAY DIFFRACTION 0.205 0.189 False True IGHV1 IGKV8 Kappa None None None None None 9h4s X Y 0 B protein NA zona pellucida sperm-binding protein 2 CELL ADHESION 03/12/25 Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form II) Mus musculus; Rattus norvegicus rattus norvegicus rattus norvegicus mus musculus Dioguardi, E., De Sanctis, D., Jovine, L. 2.02 X-RAY DIFFRACTION 0.205 0.189 False True IGHV1 IGKV8 Kappa None None None None None 9ihc H L 0 B protein NA heat-labile enterotoxin b chain TOXIN 03/12/25 CryoEM structure of a synthetic antibody, COP-2, in complex with the C-terminal domain of Clostridium perfringens Enterotoxin Clostridium perfringens; synthetic construct synthetic construct synthetic construct clostridium perfringens Pacesa, M., Goldbach, N., Vecchio, A.J., Correia, B.E. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9j66 B C 0 A | D protein | protein NA | NA spike protein s1 | spike protein s1 VIRAL PROTEIN 03/12/25 Cryo-EM structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment CAV-C65 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Jing, X., Chen, Y., Gong, P. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9knw C NA 0 B protein NA mitochondrial pyruvate carrier 2 PROTEIN TRANSPORT 03/12/25 Cryo-EM structure of apo human mitochondrial pyruvate carrier in the IMS-open conformation at pH 6.8 Homo sapiens homo sapiens homo sapiens Shi, J.H., Liang, J.M., Ma, D. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9knx C NA 0 B protein NA mitochondrial pyruvate carrier 2 PROTEIN TRANSPORT 03/12/25 Cryo-EM structure of human mitochondrial pyruvate carrier in the occluded conformation at pH 6.8 Homo sapiens homo sapiens homo sapiens Shi, J.H., Liang, J.M., Ma, D. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9kny C NA 0 B protein NA mitochondrial pyruvate carrier 2 PROTEIN TRANSPORT 03/12/25 Cryo-EM structure of pyruvate-treated human mitochondrial pyruvate carrier in the IMS-open conformation at pH 8.0 Homo sapiens homo sapiens homo sapiens Shi, J.H., Liang, J.M., Ma, D. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9l3z H L 0 A protein NA chemerin-like receptor 1,soluble cytochrome b562 MEMBRANE PROTEIN/IMMUNE SYSTEM 03/12/25 Cryo-EM structure of the inactive chemokine-like receptor 1 (CMKLR1) Escherichia coli; Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens, escherichia coli Zhu, Y., He, M., Wu, B., Zhao, Q. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9mnx D E 0 F protein NA mbp-pra/g TRANSPORT PROTEIN/IMMUNE SYSTEM 03/05/25 Cryo-EM structure of human MPC in complex with UK5099 in LMNG Escherichia coli; Homo sapiens; Mus musculus; synthetic construct mus musculus mus musculus escherichia coli Zhang, J., He, Z., Feng, L. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 9mnx C NA 0 A protein NA mitochondrial pyruvate carrier 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 03/05/25 Cryo-EM structure of human MPC in complex with UK5099 in LMNG Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens Zhang, J., He, Z., Feng, L. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ii2 S s 0 A | R protein | protein NA | NA beta-arrestin-1 | metabotropic glutamate receptor 3 MEMBRANE PROTEIN 03/05/25 Cryo-EM Structure of the 2:2 Complex of mGlu3 and beta-arrestin1 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wen, T.L., Du, M., Yang, X., Shen, Y.Q. 3.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ii2 D d 0 C | B protein | protein NA | NA beta-arrestin-1 | metabotropic glutamate receptor 3 MEMBRANE PROTEIN 03/05/25 Cryo-EM Structure of the 2:2 Complex of mGlu3 and beta-arrestin1 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wen, T.L., Du, M., Yang, X., Shen, Y.Q. 3.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8puk A B 0 NA NA NA NA IMMUNE SYSTEM 03/05/25 ChiLob 7/4 H2 HC-T219C/C224S Kappa LC-E123C/C214S F(ab')2 Homo sapiens homo sapiens homo sapiens Elliott, I.G., Fisher, H., Tews, I. 2.671 X-RAY DIFFRACTION 0.283 0.242 False True IGHV1 IGKV10 Kappa None None None None None 8pul A B 0 NA NA NA NA IMMUNE SYSTEM 03/05/25 ChiLob 7/4 H2 HC-K223C/C224S Kappa LC-C214S F(ab')2 Homo sapiens homo sapiens homo sapiens Elliott, I., Fisher, H., Tews, I. 1.93 X-RAY DIFFRACTION 0.239 0.203 False True IGHV1 IGKV10 Kappa None None None None None 8pul C D 0 NA NA NA NA IMMUNE SYSTEM 03/05/25 ChiLob 7/4 H2 HC-K223C/C224S Kappa LC-C214S F(ab')2 Homo sapiens homo sapiens homo sapiens Elliott, I., Fisher, H., Tews, I. 1.93 X-RAY DIFFRACTION 0.239 0.203 False True IGHV1 IGKV10 Kappa None None None None None 8ror H L 0 1 protein NA adhesin p1 CELL ADHESION 03/05/25 Single-particle cryo-EM of Mycoplasma pneumoniae adhesin P1 complexed with the anti-adhesive Fab fragment. Mus musculus; Mycoplasmoides pneumoniae M129 mus musculus mus musculus mycoplasmoides pneumoniae m129 Kawamoto, A., Vizarraga, D., Marcos-Silva, M., Fita, I., Miyata, M., Pinyol, J., Namba, K., Kenri, T. 2.39 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8zay H L 0 NA NA NA NA PROTEIN BINDING 03/05/25 Crystal structure of Fab Mus musculus mus musculus mus musculus Adachi, Y., Nogi, T. 2.3 X-RAY DIFFRACTION 0.269 0.218 False True IGHV7 IGKV6 Kappa None None None None None 8zay I M 0 NA NA NA NA PROTEIN BINDING 03/05/25 Crystal structure of Fab Mus musculus mus musculus mus musculus Adachi, Y., Nogi, T. 2.3 X-RAY DIFFRACTION 0.269 0.218 False True IGHV7 IGKV6 Kappa None None None None None 9b65 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/05/25 Biased agonist bound CB1-Gi structure Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Rangari, V.A., O'Brien, E.S., Kobilka, B.K., Krishna Kumar, K., Majumdar, S. 3.03 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9bj2 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/25 Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C1533 (local refinement of NTD and C1533) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rubio, A.A., Abernathy, M.E., Barnes, C.O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9bj3 C D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/25 Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C1596 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rubio, A.A., Abernathy, M.E., Barnes, C.O. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bj3 E F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/25 Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C1596 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rubio, A.A., Abernathy, M.E., Barnes, C.O. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bj3 H L 0 S protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/25 Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C1596 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rubio, A.A., Abernathy, M.E., Barnes, C.O. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bj4 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/25 Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C952 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rubio, A.A., Abernathy, M.E., Barnes, C.O. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 9bj4 D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/25 Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C952 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rubio, A.A., Abernathy, M.E., Barnes, C.O. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 9bj4 F G 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/25 Structure of the SARS-CoV-2 S 6P trimer complex with the human neutralizing antibody Fab fragment, C952 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rubio, A.A., Abernathy, M.E., Barnes, C.O. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 9fzq B NA 0 A protein NA mitochondrial brown fat uncoupling protein 1 TRANSPORT PROTEIN 03/05/25 Proton conductance by human uncoupling protein 1 is inhibited by both purine and pyrimidine nucleotides Homo sapiens; Lama glama lama glama homo sapiens Jones, S.A., Sowton, A.P., Lacabanne, D., King, M.S., Palmer, S.M., Zogg, T., Pardon, E., Steyaert, J., Ruprecht, J.J., Kunji, E.R.S. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fzq C NA 0 A protein NA mitochondrial brown fat uncoupling protein 1 TRANSPORT PROTEIN 03/05/25 Proton conductance by human uncoupling protein 1 is inhibited by both purine and pyrimidine nucleotides Homo sapiens; Lama glama lama glama homo sapiens Jones, S.A., Sowton, A.P., Lacabanne, D., King, M.S., Palmer, S.M., Zogg, T., Pardon, E., Steyaert, J., Ruprecht, J.J., Kunji, E.R.S. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ii3 S s 0 A | R protein | protein NA | NA beta-arrestin-1 | metabotropic glutamate receptor 3 MEMBRANE PROTEIN 03/05/25 Cryo-EM Structure of the 2:1 Complex of mGlu3 and beta-arrestin1 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wen, T.L., Du, M., Yang, X., Shen, Y.Q. 3.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9j82 H L 0 A protein NA putative zinc metalloprotease aq_1964 HYDROLASE 03/05/25 Protease in complex with Fab Aquifex aeolicus VF5; Mus musculus mus musculus mus musculus aquifex aeolicus vf5 Asahi, K., Hirose, M., Aruga, R., Kato, T., Nogi, T. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV6 Kappa None None None None None 9j83 H L 0 A protein NA putative zinc metalloprotease aq_1964 HYDROLASE 03/05/25 Cryo-EM structure of intramembrane protease Aquifex aeolicus VF5; Escherichia coli; Mus musculus mus musculus mus musculus aquifex aeolicus vf5 Asahi, K., Hirose, M., Aruga, R., Kato, T., Nogi, T. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV6 Kappa None None None None None 9mny D E 0 F protein NA mbp-pra/g TRANSPORT PROTEIN/IMMUNE SYSTEM 03/05/25 Cryo-EM structure of human MPC with pyruvate Escherichia coli; Homo sapiens; Mus musculus; synthetic construct mus musculus mus musculus escherichia coli Zhang, J., He, Z., Feng, L. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 9mny C NA 0 A protein NA mitochondrial pyruvate carrier 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 03/05/25 Cryo-EM structure of human MPC with pyruvate Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens Zhang, J., He, Z., Feng, L. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9mnz D E 0 F protein NA mbp-pra/g TRANSPORT PROTEIN/IMMUNE SYSTEM 03/05/25 Cryo-EM structure of human MPC in complex with UK5099 in nanodiscs Escherichia coli; Homo sapiens; Mus musculus; synthetic construct mus musculus mus musculus escherichia coli Zhang, J., He, Z., Feng, L. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 9mnz C NA 0 A protein NA mitochondrial pyruvate carrier 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 03/05/25 Cryo-EM structure of human MPC in complex with UK5099 in nanodiscs Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens Zhang, J., He, Z., Feng, L. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jsr C c 0 A protein NA engineered g-alpha-q MEMBRANE PROTEIN 01/22/25 Cryo-EM structure of the anamorelin-bound ghrelin receptor and Gq complex Homo sapiens; Lama glama; Mus musculus mus musculus homo sapiens Im, D., Shimura, Y., Asada, H., Iwata, S. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jsr N NA 0 A | G | B protein | protein | protein NA | NA | NA engineered g-alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/22/25 Cryo-EM structure of the anamorelin-bound ghrelin receptor and Gq complex Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens | homo sapiens Im, D., Shimura, Y., Asada, H., Iwata, S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8tii H L 0 A | R protein | peptide NA | NA beta-arrestin-1 | atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 Human ACKR3 phosphorylated by GRK2 in complex with Arrestin2 in nanodisc Bos taurus; Homo sapiens; synthetic construct synthetic construct synthetic construct bos taurus | homo sapiens Chen, Q., Tesmer, J.J.G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tii N NA 0 NA NA NA NA SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 Human ACKR3 phosphorylated by GRK2 in complex with Arrestin2 in nanodisc Bos taurus; Homo sapiens; synthetic construct synthetic construct Chen, Q., Tesmer, J.J.G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tmc H L 0 A | E protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C12 and 20 mM MgCl2, State MG20-2 Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmc F G 0 C | B protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C12 and 20 mM MgCl2, State MG20-2 Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmg H L 0 D | C protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2A Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmg F G 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2A Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmh H L 0 D | C protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2B Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmh F G 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2B Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmi H L 0 D | C protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2C Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmi F G 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2C Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmj H L 0 D | C protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2D Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmj F G 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2D Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmk H L 0 D | C protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-2C Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmk F G 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-2C Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tml H L 0 D | C protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-2B Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tml F G 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-2B Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmm H L 0 D | C protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-2A Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmm F G 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-2A Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tq5 H L 0 B | A protein | protein NA | NA beta-2-microglobulin | hla class i histocompatibility antigen b alpha chain (hla- IMMUNE SYSTEM 02/05/25 Crystal structure of Fab DX17 in complex with MHC-I (HLA-B*44:05) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Jiang, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 2.3 X-RAY DIFFRACTION 0.234 0.193 False True IGHV2 IGKV6 Kappa None None None None None 8tq6 F G 0 NA NA NA NA IMMUNE SYSTEM 02/05/25 Crystal structure of Fab.B1.23.2 in complex with MHC-I (HLA-B*44:05) Homo sapiens; Mus musculus; synthetic construct mus musculus mus musculus Jiang, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 3.2 X-RAY DIFFRACTION 0.268 0.240 False True IGHV1 IGKV14 Kappa None None None None None 8tq6 H L 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen b alpha chain (hla- | mhc class ii antigen peptide IMMUNE SYSTEM 02/05/25 Crystal structure of Fab.B1.23.2 in complex with MHC-I (HLA-B*44:05) Homo sapiens; Mus musculus; synthetic construct mus musculus mus musculus homo sapiens | synthetic construct Jiang, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 3.2 X-RAY DIFFRACTION 0.268 0.240 False True IGHV1 IGKV14 Kappa None None None None None 8ya0 V NA 0 Y | E protein | protein NA | NA protein translocase subunit secy | protein translocase subunit sece PROTEIN TRANSPORT 02/26/25 Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+7C) Aequorea victoria; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli K-12; Geobacillus thermodenitrificans NG80-2; Lama glama lama glama geobacillus thermodenitrificans ng80-2 | geobacillus thermodenitrificans ng80-2 Ou, X., Ma, C., Sun, D., Xu, J., Wu, X., Gao, N., Li, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ya0 C NA 0 G | A protein | protein NA | NA green fluorescent protein | protein translocase subunit seca PROTEIN TRANSPORT 02/26/25 Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+7C) Aequorea victoria; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli K-12; Geobacillus thermodenitrificans NG80-2; Lama glama lama glama aequorea victoria | bacillus subtilis subsp. subtilis str. 168 Ou, X., Ma, C., Sun, D., Xu, J., Wu, X., Gao, N., Li, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ybz F I 0 C protein NA spike glycoprotein PROTEIN BINDING 02/19/25 State - II: Spike 3-up RBD with THSC20.HVTR26 (Fab26) Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Rencilin, C.F., Bhattacharya, J., Dutta, S. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8ybz E H 0 B protein NA spike glycoprotein PROTEIN BINDING 02/19/25 State - II: Spike 3-up RBD with THSC20.HVTR26 (Fab26) Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Rencilin, C.F., Bhattacharya, J., Dutta, S. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8ybz D G 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein PROTEIN BINDING 02/19/25 State - II: Spike 3-up RBD with THSC20.HVTR26 (Fab26) Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus | severe acute respiratory syndrome coronavirus Rencilin, C.F., Bhattacharya, J., Dutta, S. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8z7j S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/22/25 Cryo-EM structure of APJR-Gi complex with agonistic antibody Homo sapiens homo sapiens homo sapiens | homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 3.12 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8z7j N NA 0 R protein NA soluble cytochrome b562,apelin receptor SIGNALING PROTEIN 01/22/25 Cryo-EM structure of APJR-Gi complex with agonistic antibody Homo sapiens homo sapiens homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8zf9 S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN/IMMUNE SYSTEM 02/26/25 Cryo-EM structure of the mmGPR4-Gs complex in pH7.2 Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens Wen, X., Rong, N.K., Yang, F., Sun, J.P. 2.56 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zf9 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/26/25 Cryo-EM structure of the mmGPR4-Gs complex in pH7.2 Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Wen, X., Rong, N.K., Yang, F., Sun, J.P. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ban E F 0 A | D protein | protein NA | NA muellerian-inhibiting factor | muellerian-inhibiting factor SIGNALING PROTEIN/IMMUNE SYSTEM 01/29/25 The Anti-Mullerian Hormone prodomain in complex with the growth factor and 6E11 Fab in C1 symmetry Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Howard, J.A., Thompson, T.B. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9ban G H 0 C | B peptide | protein NA | NA muellerian-inhibiting factor | muellerian-inhibiting factor SIGNALING PROTEIN/IMMUNE SYSTEM 01/29/25 The Anti-Mullerian Hormone prodomain in complex with the growth factor and 6E11 Fab in C1 symmetry Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Howard, J.A., Thompson, T.B. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9bao E F 0 A | D protein | protein NA | NA muellerian-inhibiting factor | muellerian-inhibiting factor SIGNALING PROTEIN/IMMUNE SYSTEM 01/29/25 The Anti-Mullerian Hormone prodomain in complex with the growth factor and 6E11 Fab in C2 symmetry Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Howard, J.A., Thompson, T.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9bao G H 0 C | B protein | protein NA | NA muellerian-inhibiting factor | muellerian-inhibiting factor SIGNALING PROTEIN/IMMUNE SYSTEM 01/29/25 The Anti-Mullerian Hormone prodomain in complex with the growth factor and 6E11 Fab in C2 symmetry Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Howard, J.A., Thompson, T.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9e76 Q NA 0 F | E protein | protein NA | NA v-type proton atpase subunit c | v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 1WVA25 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Wilkens, S., Knight, K. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9e76 R NA 0 H | G protein | protein NA | NA v-type proton atpase subunit c | v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 1WVA25 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Wilkens, S., Knight, K. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9e76 S NA 0 J | I protein | protein NA | NA v-type proton atpase subunit c | v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 1WVA25 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Wilkens, S., Knight, K. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9e76 T NA 0 L | K | A | M | C protein | protein | protein | protein | protein NA | NA | NA | NA | NA v-type proton atpase subunit c | v-type proton atpase subunit c | v-type proton atpase subunit a, vacuolar isoform | v-type proton atpase subunit e | v-type proton atpase subunit c'' PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 1WVA25 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae | saccharomyces cerevisiae | saccharomyces cerevisiae | saccharomyces cerevisiae | saccharomyces cerevisiae Wilkens, S., Knight, K. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9e7l X NA 0 L | A | M | C protein | protein | protein | protein NA | NA | NA | NA v-type proton atpase subunit c | v-type proton atpase subunit a, vacuolar isoform | v-type proton atpase subunit e | v-type proton atpase subunit c'' PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae | saccharomyces cerevisiae | saccharomyces cerevisiae | saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e7l W NA 0 K protein NA v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e7l V NA 0 J protein NA v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e7l U NA 0 I protein NA v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e7l T NA 0 H protein NA v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e7l S NA 0 G protein NA v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e7l R NA 0 F protein NA v-type proton atpase subunit c PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e7l Q NA 0 E | D protein | protein NA | NA v-type proton atpase subunit c | v-type proton atpase subunit c' PROTON TRANSPORT 02/05/25 Yeast V-ATPase Vo proton channel bound to nanobody 2WVA7 Lama glama; Saccharomyces cerevisiae lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Wilkens, S., Knight, K., Roh, S.-H., Park, J.B. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9mxi A B 0 NA NA NA NA IMMUNE SYSTEM/TOXIN 02/12/25 Crystal Structure of synthetic antibody, COP-2, in complex with the C-terminal domain of Clostridium perfringens Enterotoxin Clostridium perfringens; synthetic construct synthetic construct synthetic construct Ogbu, C.P., Kapoor, S., Vecchio, A.J. 2.2 X-RAY DIFFRACTION 0.233 0.182 False True IGHV3 IGKV1 Kappa None None None None None 9mxi C D 0 NA NA NA NA IMMUNE SYSTEM/TOXIN 02/12/25 Crystal Structure of synthetic antibody, COP-2, in complex with the C-terminal domain of Clostridium perfringens Enterotoxin Clostridium perfringens; synthetic construct synthetic construct synthetic construct Ogbu, C.P., Kapoor, S., Vecchio, A.J. 2.2 X-RAY DIFFRACTION 0.233 0.182 False True IGHV3 IGKV1 Kappa None None None None None 9mxi E F 0 G protein NA heat-labile enterotoxin b chain IMMUNE SYSTEM/TOXIN 02/12/25 Crystal Structure of synthetic antibody, COP-2, in complex with the C-terminal domain of Clostridium perfringens Enterotoxin Clostridium perfringens; synthetic construct synthetic construct synthetic construct clostridium perfringens Ogbu, C.P., Kapoor, S., Vecchio, A.J. 2.2 X-RAY DIFFRACTION 0.233 0.182 False True IGHV3 IGKV1 Kappa None None None None None 8tq4 C D 0 F | E protein | protein NA | NA beta-2-microglobulin | h2 class i histocompatibility antigen d-d alpha chain (h2-dd) IMMUNE SYSTEM 02/05/25 Crystal structure of Fab M142 in complex with MHC-I (H2-Dd) Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus mus musculus | mus musculus Jiang, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 3.59 X-RAY DIFFRACTION 0.270 0.221 False True IGHV8 IGKV14 Kappa None None None None None 8tq4 H L 0 B | A protein | protein NA | NA beta-2-microglobulin | h2 class i histocompatibility antigen d-d alpha chain (h2-dd) IMMUNE SYSTEM 02/05/25 Crystal structure of Fab M142 in complex with MHC-I (H2-Dd) Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus mus musculus | mus musculus Jiang, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 3.59 X-RAY DIFFRACTION 0.270 0.221 False True IGHV8 IGKV14 Kappa None None None None None 9b9j H L 0 A | B protein | protein NA | NA integrin alpha-5 light chain | integrin beta-1 SIGNALING PROTEIN,CELL ADHESION 02/05/25 Integrin alpha-5 beta-1 in complex with BIIG2 Fab Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens | homo sapiens Nguyen, A., Azumaya, C.M., Campbell, M.G. 2.6 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV16 Kappa None None None None None 8kdd H L 0 A protein NA 4f2 cell-surface antigen heavy chain TRANSPORT PROTEIN 02/12/25 Structure of LAT1-CD98hc-Fab170 in complex with JPH203, consensus map Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, Y. 3.83 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 8kdg H L 0 A protein NA 4f2 cell-surface antigen heavy chain TRANSPORT PROTEIN 02/12/25 Structure of LAT1-CD98hc-Fab170 in complex with BCH, consensus map Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, Y. 3.68 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 8kdi H L 0 A protein NA 4f2 cell-surface antigen heavy chain TRANSPORT PROTEIN/IMMUNE SYSTEM 02/12/25 Structure of apo inward-open LAT1-CD98hc-Fab170 in nanodisc, consensus map Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lee, Y. 3.58 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 8qv5 B NA 0 A protein NA sphingosine-1-phosphate transporter spns2 LIPID TRANSPORT 02/19/25 Structure of human SPNS2 in LMNG Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, H.Z., Pike, A.C.W., McKinley, G., Mukhopadhyay, S.M.M., Moreau, C., Scacioc, A., Abrusci, P., Borkowska, O., Chalk, R., Stefanic, S., Burgess-Brown, N., Duerr, K.L., Sauer, D.B. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8qv6 B NA 0 A protein NA sphingosine-1-phosphate transporter spns2 LIPID TRANSPORT 02/19/25 Structure of human SPNS2 in DDM Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Li, H.Z., Pike, A.C.W., McKinley, G., Mukhopadhyay, S.M.M., Moreau, C., Scacioc, A., Abrusci, P., Borkowska, O., Chalk, R., Stefanic, S., Burgess-Brown, N., Duerr, K.L., Sauer, D.B. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rpd NA A 0 NA NA NA NA IMMUNE SYSTEM 01/29/25 Crystal structure of the SMA homodimer Homo sapiens homo sapiens Maerivoet, A., Crabbe, T., Antonyuk, S.V., Madine, J. 2.15 X-RAY DIFFRACTION 0.254 0.190 False True NA IGKV4 Kappa None None None None None 8rpe B E 0 NA NA NA NA IMMUNE SYSTEM 01/29/25 Crystal structure of the SMA:VH1 Complex at 1.2 A resolution Homo sapiens; Lama lama homo sapiens Maerivoet, A., Crabbe, T., Antonyuk, S.V., Madine, J. 1.2 X-RAY DIFFRACTION 0.144 0.112 False True IGHV5 IGKV4 Kappa None None None None None 8rwb H L 0 P protein NA ul16-binding protein 6 IMMUNE SYSTEM 02/12/25 Crystal structure of ULBP6 in complex with a blocking antibody Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Bharill, S., Chen, I., Ivic, N., Bahrami Dizicheh, Z., Wu, Y., Doamekpor, S., Koenig, P., Fuh, G. 2.307 X-RAY DIFFRACTION 0.287 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8til H L 0 A | R protein | peptide NA | NA beta-arrestin-2 | atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 Human ACKR3 phosphorylated by GRK5 in complex with Arrestin3 reconstructed without receptor/micelle Bos taurus; Homo sapiens; synthetic construct synthetic construct synthetic construct bos taurus | homo sapiens Chen, Q., Tesmer, J.J.G. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tin H L 0 A protein NA beta-arrestin-2 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 Human ACKR3 phosphorylated by GRK2 in complex with Arrestin3 reconstructed without receptor/micelle Bos taurus; Homo sapiens; synthetic construct synthetic construct synthetic construct bos taurus Chen, Q., Tesmer, J.J.G. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tio H L 0 A | R protein | peptide NA | NA beta-arrestin-1 | atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 Human ACKR3 with C tail extended by 12 glycines phosphorylated by GRK5 in complex with Arrestin2 reconstructed without receptor/micelle Bos taurus; Homo sapiens; synthetic construct synthetic construct bos taurus bos taurus | homo sapiens Chen, Q., Tesmer, J.J.G. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmb H L 0 A | E protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C12 and 20 mM MgCl2, State MG20-1 Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmd H L 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-1A Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tme H L 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-1B Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmf H L 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-1C Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmn H L 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-1D Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmo H L 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-1C Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmp H L 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-1B Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tmq H L 0 B | A protein | protein NA | NA cobalt/magnesium transport protein cora | cobalt/magnesium transport protein cora MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of magnesium depleted CorA in complex with conformation-specific synthetic antibody C18, State MGD-1A Homo sapiens; Thermotoga maritima homo sapiens homo sapiens thermotoga maritima | thermotoga maritima Erramilli, S.K., Perozo, E., Kossiakoff, A.A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8utd D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/26/25 CryoEM Structure of HCA2-Gi1 in complex with MK-1903 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Krumm, B.E., Kang, H.J., Diberto, J.F., Kapolka, N.J., Gumpper, R.H., Olsen, R.H.J., Huang, X.P., Zhang, S., Fay, J.F., Roth, B.L. 3.24 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8uuj D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/26/25 CryoEM Structure of HCA2 DREADD Gi1 in complex with FCH-2296413 Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Krumm, B.E., Kang, H.J., Diberto, J.F., Kapolka, N.J., Gumpper, R.H., Olsen, R.H.J., Huang, X.P., Zhang, S., Fay, J.F., Roth, B.L. 2.62 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8v13 H L 0 T protein NA short neurotoxin 1 ANTITOXIN/IMMUNE SYSTEM 01/29/25 Crystal structure of Black mamba toxin in complex with Centi-SNX-B03 antibody Dendraspis polylepis polylepis; Homo sapiens homo sapiens homo sapiens dendraspis polylepis polylepis Pletnev, S., Glanville, J., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.229 0.181 False True IGHV3 IGLV3 Lambda None None None None None 8v13 h l 0 t protein NA unknown ANTITOXIN/IMMUNE SYSTEM 01/29/25 Crystal structure of Black mamba toxin in complex with Centi-SNX-B03 antibody Dendraspis polylepis polylepis; Homo sapiens homo sapiens homo sapiens dendraspis polylepis polylepis Pletnev, S., Glanville, J., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.229 0.181 False False IGHV3 IGLV3 Lambda None None None None None 8vj9 H L 0 A | R protein | peptide NA | NA beta-arrestin-2 | atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 CryoEM structure of human ACKR3 phosphorylated by GRK5 in complex with Arrestin3 variant with the C edge loop from Arrestin2 inserted Bos taurus; Homo sapiens; synthetic construct synthetic construct synthetic construct bos taurus | homo sapiens Chen, Q., Tesmer, J.J.G. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vkx H L 0 A protein NA vp1 VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 VX22 bound to GII.4 P domain Homo sapiens; Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU homo sapiens homo sapiens norovirus hu/gii.4/sydney/nsw0514/2012/au Olia, A.S., Park, J., Lindesmith, L.C., Kwong, P.D. 3.35 X-RAY DIFFRACTION 0.272 0.245 False True IGHV3 IGLV2 Lambda None None None None None 8vqf B A 0 C protein NA major allergen can f 1 ALLERGEN/IMMUNE SYSTEM 01/22/25 X-ray crystal structure of natural Can f 1 in complex with human IgE 1J11 Fab Canis lupus familiaris; Homo sapiens homo sapiens homo sapiens canis lupus familiaris Khatri, K., Ball, A., Richardson, C.M., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 3.109 X-RAY DIFFRACTION 0.268 0.248 False True IGHV3 IGLV3 Lambda None None None None None 8w5d H L 0 C | c protein | protein NA | NA minor capsid protein a1 | unknown IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab1 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8w5e H L 0 C | c protein | protein NA | NA minor capsid protein a1 | unknown IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab4 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV17 Kappa None None None None None 8w5f H L 0 c | C protein | protein NA | NA unknown | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab6 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 8w5g H L 0 B | A protein | protein NA | NA minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab7 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV9 Kappa None None None None None 8w5h H L 0 A | B protein | protein NA | NA minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab10 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV10 Kappa None None None None None 8w5i H L 0 B | E | D | C | A protein | protein | protein | protein | protein NA | NA | NA | NA | NA minor capsid protein a1 | minor capsid protein a1 | minor capsid protein a1 | minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab14 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8w5l H L 0 B | C | A protein | protein | protein NA | NA | NA minor capsid protein a1 | minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab16 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8w5m H L 0 A | b | B protein | protein | protein NA | NA | NA minor capsid protein a1 | unknown | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab17 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 8w5n H L 0 A | C | B protein | protein | protein NA | NA | NA minor capsid protein a1 | minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab21 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8w5o H L 0 B | b | A protein | protein | protein NA | NA | NA minor capsid protein a1 | unknown | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab31 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 8w5p H L 0 c | C protein | protein NA | NA unknown | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab40 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Hua, Z.L., Hou, B.D., Zhu, P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 8w5q H L 0 C | c protein | protein NA | NA minor capsid protein a1 | unknown IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab45 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV12 Kappa None None None None None 8w5r H L 0 A | C | B protein | protein | protein NA | NA | NA minor capsid protein a1 | minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab53 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 8w5t H L 0 B | A protein | protein NA | NA minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab57 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Zhu, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8w5u H L 0 c | C protein | protein NA | NA unknown | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of QbN10F-Ab40 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hou, B.D., Zhu, P. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 8w5v H L 0 c | C protein | protein NA | NA unknown | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of QbN10K-Ab40 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 8w5w H L 0 B | A protein | protein NA | NA minor capsid protein a1 | minor capsid protein a1 IMMUNE SYSTEM 02/26/25 Cryo-EM structure of Qb-Ab8 Escherichia phage Qbeta; Mus musculus mus musculus mus musculus escherichia phage qbeta | escherichia phage qbeta Bao, K.Y., Li, R.H., Hua, Z.L., Hou, B.D., Zhu, P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 8x9t S s 0 A | B protein | protein NA | NA gs protein alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/12/25 Identification, structure and agonist design of an androgen membrane receptor Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Ping, Y.Q., Yang, Z. 2.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xlk E F 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native tri-heteromeric GluN1-GluN2A-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculoides; Rattus norvegicus mus musculoides mus musculoides rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xlk G H 0 B protein NA glutamate receptor ionotropic, nmda 2a MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native tri-heteromeric GluN1-GluN2A-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculoides; Rattus norvegicus mus musculoides mus musculoides rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 4.2 ELECTRON MICROSCOPY NA NA False False IGHV8 IGKV12 Kappa None None None None None 8xlk I J 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native tri-heteromeric GluN1-GluN2A-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculoides; Rattus norvegicus mus musculoides mus musculoides rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xlk K L 0 D protein NA glutamate receptor ionotropic, nmda 2b MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native tri-heteromeric GluN1-GluN2A-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculoides; Rattus norvegicus mus musculoides mus musculoides rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV19 Kappa None None None None None 8xqe S s 0 A | B protein | protein NA | NA g protein subunit alpha i1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/22/25 Cryo-EM structure of human dimeric APJR-Gi complex with apelin-13. Homo sapiens homo sapiens homo sapiens | homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 3.48 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xqf S s 0 A | B protein | protein NA | NA g protein subunit alpha i1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/22/25 Cryo-EM structure of human monomeric APJR-Gi complex with apelin-13. Homo sapiens homo sapiens homo sapiens | homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 3.13 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xqj A NA 0 C protein NA soluble cytochrome b562,apelin receptor SIGNALING PROTEIN 01/22/25 Cryo-EM structure of human dimeric APJR complex with antagonistic antibody Homo sapiens homo sapiens homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xqj B NA 0 D protein NA soluble cytochrome b562,apelin receptor SIGNALING PROTEIN 01/22/25 Cryo-EM structure of human dimeric APJR complex with antagonistic antibody Homo sapiens homo sapiens homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xsd H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 BA.5 Spike complex with CR9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xsd G J 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 BA.5 Spike complex with CR9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xsd I K 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 BA.5 Spike complex with CR9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xwz NA A 0 NA NA NA NA IMMUNE SYSTEM 01/22/25 Non-crystalline proximal tubulopathy and crystalline cast nephropathy-causing Bence-Jones protein PT-CN: An entire immunoglobulin kappa light chain dimer Homo sapiens homo sapiens Ezawa, T., Otomo, R., Nozawa, K., Kyoya, S., Noguchi, K., Yohda, M., Odaka, M., Matsumura, H. 2.3 X-RAY DIFFRACTION 0.257 0.204 False False NA IGKV1 Kappa None None None None None 8xwz NA B 0 NA NA NA NA IMMUNE SYSTEM 01/22/25 Non-crystalline proximal tubulopathy and crystalline cast nephropathy-causing Bence-Jones protein PT-CN: An entire immunoglobulin kappa light chain dimer Homo sapiens homo sapiens Ezawa, T., Otomo, R., Nozawa, K., Kyoya, S., Noguchi, K., Yohda, M., Odaka, M., Matsumura, H. 2.3 X-RAY DIFFRACTION 0.257 0.204 False False NA IGKV1 Kappa None None None None None 8xxz S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE 02/26/25 Structure of CXCR3 in the apo-state (Full map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8y01 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 02/12/25 Cryo-EM structure of Medium-wave-sensitive opsin 1 Bos taurus; Homo sapiens homo sapiens homo sapiens | homo sapiens Peng, Q., Jiang, H.H., Cheng, X.Y., Li, J., Zhang, J. 2.48 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8y3h G H 0 A protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 N153Q mutant in complex with human antibody 2D22 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8y3h I J 0 C protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 N153Q mutant in complex with human antibody 2D22 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8y3h K L 0 E protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 N153Q mutant in complex with human antibody 2D22 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8y3i G H 0 A protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 N153Q mutant in complex with human antibody C10 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8y3i I J 0 E protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 N153Q mutant in complex with human antibody C10 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8y3i K L 0 C protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 N153Q mutant in complex with human antibody C10 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8y3k G H 0 A protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 in complex with human antibody 2D22 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8y3k I J 0 E protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 in complex with human antibody 2D22 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8y3k K L 0 C protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/29/25 Cryo-EM structure of dengue virus serotype 2 strain D2Y98P-PP1 in complex with human antibody 2D22 Fab at 37 deg C dengue virus type 2; Homo sapiens homo sapiens homo sapiens dengue virus type 2 Fibriansah, G., Ng, T.S., Lim, X.N., Tan, A.W.K., Shi, J., Lok, S.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8y51 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/12/25 Cryo-EM structure of the BRS3-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Li, C., Xu, Y., Yin, W., Xu, H.E. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8y62 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/05/25 Cryo-EM structure of the C16:0 ceramide-bound FPR2-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Sun, J.P., Jiang, C.T., Kong, W., Yu, X., Cai, K., Guo, L.L. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8y9s B NA 0 A protein NA albumin PROTEIN BINDING 02/12/25 Crystal structure of nanobody MY6321 bound to human serum albumin (HSA) Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Ding, Y., Zhong, P.Y. 2.88 X-RAY DIFFRACTION 0.293 0.230 False True IGHV3 NA NA None None None None None 8y9s D NA 0 C protein NA albumin PROTEIN BINDING 02/12/25 Crystal structure of nanobody MY6321 bound to human serum albumin (HSA) Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Ding, Y., Zhong, P.Y. 2.88 X-RAY DIFFRACTION 0.293 0.230 False True IGHV3 NA NA None None None None None 8y9t B NA 0 A protein NA albumin PROTEIN BINDING 02/12/25 Crystal structure of nanobody MY6322 bound to human serum albumin (HSA) Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Ding, Y., Zhong, P.Y. 2.4 X-RAY DIFFRACTION 0.324 0.263 False True IGHV3 NA NA None None None None None 8y9u B NA 0 A protein NA albumin PROTEIN BINDING 02/12/25 Crystal structure of nanobody MY6323 bound to human serum albumin (HSA) Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Ding, Y., Zhong, P.Y. 3.1 X-RAY DIFFRACTION 0.316 0.273 False True IGHV3 NA NA None None None None None 8y9u D NA 0 C protein NA albumin PROTEIN BINDING 02/12/25 Crystal structure of nanobody MY6323 bound to human serum albumin (HSA) Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Ding, Y., Zhong, P.Y. 3.1 X-RAY DIFFRACTION 0.316 0.273 False True IGHV3 NA NA None None None None None 8y9z V NA 0 Y | E protein | protein NA | NA protein translocase subunit secy | protein translocase subunit sece PROTEIN TRANSPORT 02/26/25 Structure of the SecA-SecY complex with the substrate HmBRI-3TM Bacillus subtilis subsp. subtilis str. 168; Geobacillus thermodenitrificans NG80-2; Haloarcula marismortui ATCC 43049; Lama glama lama glama geobacillus thermodenitrificans ng80-2 | geobacillus thermodenitrificans ng80-2 Ou, X., Ma, C., Sun, D., Xu, J., Wu, X., Gao, N., Li, L. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ya2 C NA 0 G | A protein | protein NA | NA green fluorescent protein | protein translocase subunit seca PROTEIN TRANSPORT 02/26/25 Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+20C) Aequorea victoria; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli K-12; Geobacillus thermodenitrificans NG80-2; Lama glama lama glama aequorea victoria | bacillus subtilis subsp. subtilis str. 168 Ou, X., Ma, C., Sun, D., Xu, J., Wu, X., Gao, N., Li, L. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8yat B NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat C NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat D NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat F NA 0 E protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat G NA 0 E protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat H NA 0 E protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat J NA 0 I protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat K NA 0 I protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat L NA 0 I protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat N NA 0 M protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat O NA 0 M protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yat P NA 0 M protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 02/12/25 SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Camelus dromedarius; Homo sapiens; Vicugna pacos camelus dromedarius homo sapiens Cheng, S. 3.94 X-RAY DIFFRACTION 0.368 0.303 False True IGHV1 NA NA None None None None None 8yby A C 0 B protein NA spike glycoprotein PROTEIN BINDING 02/19/25 State - I: Spike 2-up RBD with THSC20.HVTR26 (Fab26) - single Fab masked Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Rencilin, C.F., Bhattacharya, J., Dutta, S. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8yef A B 0 J | I | K | H protein | protein | protein | protein NA | NA | NA | NA major capsid protein l1 | major capsid protein l1 | major capsid protein l1 | major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 02/26/25 HPV6 L1 pentamer in complex with Fab F5-77 Alphapapillomavirus 10; Homo sapiens homo sapiens homo sapiens alphapapillomavirus 10 | alphapapillomavirus 10 | alphapapillomavirus 10 | alphapapillomavirus 10 Wang, X., Fu, W. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8ygt H L 0 B | A protein | peptide NA | NA outer capsid protein vp4 | outer capsid protein vp4 VIRUS 02/12/25 Cryo-EM structure of simian rotavirus SA11 VP4 in complex with nAb 7H13-I54G mutant (left side) Mus musculus; Rotavirus A mus musculus mus musculus rotavirus a | rotavirus a Huang, Y., Sun, H., Zheng, Q., Li, S., Ge, S., Xia, N. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV6 Kappa None None None None None 8ygu H L 0 B | C | A protein | peptide | peptide NA | NA | NA outer capsid protein vp4 | outer capsid protein vp4 | outer capsid protein vp4 VIRUS 02/12/25 Cryo-EM structure of simian rotavirus SA11 VP4 in complex with nAb 7H13-I54G mutant (right side) Mus musculus; Rotavirus A mus musculus mus musculus rotavirus a | rotavirus a | rotavirus a Huang, Y., Sun, H., Zheng, Q., Li, S., Ge, S., Xia, N. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV6 Kappa None None None None None 8yor B A 0 E peptide NA histidine--trna ligase, cytoplasmic SPLICING/IMMUNE SYSTEM 02/12/25 Complex of HARSWHEP and a-HARSWHEP Fab Homo sapiens homo sapiens homo sapiens homo sapiens Zhai, L. 2.3 X-RAY DIFFRACTION 0.273 0.227 False True IGHV1 IGKV3 Kappa None None None None None 8yor D C 0 F peptide NA histidine--trna ligase, cytoplasmic SPLICING/IMMUNE SYSTEM 02/12/25 Complex of HARSWHEP and a-HARSWHEP Fab Homo sapiens homo sapiens homo sapiens homo sapiens Zhai, L. 2.3 X-RAY DIFFRACTION 0.273 0.227 False True IGHV1 IGKV3 Kappa None None None None None 8z4e C B 0 A protein NA neuraminidase VIRAL PROTEIN 01/22/25 Structure of human 18_14D scFv and 1G01 scFv in complex with influenza virus neuraminidase from A/Yunan/DQ001/2016 (H5N6) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, M., Peng, Q., Gao, Y., Shi, Y. 3.0 ELECTRON MICROSCOPY NA NA True True IGHV1 IGLV2 Lambda None None None None None 8z4e E F 0 A protein NA neuraminidase VIRAL PROTEIN 01/22/25 Structure of human 18_14D scFv and 1G01 scFv in complex with influenza virus neuraminidase from A/Yunan/DQ001/2016 (H5N6) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Wang, M., Peng, Q., Gao, Y., Shi, Y. 3.0 ELECTRON MICROSCOPY NA NA True True IGHV3 IGKV1 Kappa None None None None None 8z6q E D 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 XBB.1.16 Spike in complex with CYFN1006-1(S-CYFN1006-1 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 5.41 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6q G F 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 XBB.1.16 Spike in complex with CYFN1006-1(S-CYFN1006-1 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 5.41 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6q I H 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 XBB.1.16 Spike in complex with CYFN1006-1(S-CYFN1006-1 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 5.41 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6q N M 0 J protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 XBB.1.16 Spike in complex with CYFN1006-1(S-CYFN1006-1 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 5.41 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6q P O 0 K protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 XBB.1.16 Spike in complex with CYFN1006-1(S-CYFN1006-1 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 5.41 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6q R Q 0 L protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 XBB.1.16 Spike in complex with CYFN1006-1(S-CYFN1006-1 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 5.41 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6r E D 0 A protein NA spike glycoprotein,fibritin,spike glycoprotein,fibritin,spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of XBB.1.16 S trimer with 3 down-RBDs complex with antibody CYFN1006-1. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6r G F 0 B protein NA spike glycoprotein,fibritin,spike glycoprotein,fibritin,spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of XBB.1.16 S trimer with 3 down-RBDs complex with antibody CYFN1006-1. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6r I H 0 C protein NA spike glycoprotein,fibritin,spike glycoprotein,fibritin,spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of XBB.1.16 S trimer with 3 down-RBDs complex with antibody CYFN1006-1. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6s E D 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Structure of XBB.1.16 S trimer with 2 down-RBDs complex with antibody CYFN1006-1. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6s G F 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Structure of XBB.1.16 S trimer with 2 down-RBDs complex with antibody CYFN1006-1. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6s I H 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Structure of XBB.1.16 S trimer with 2 down-RBDs complex with antibody CYFN1006-1. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6t B C 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of XBB.1.16 RBD in complex with antibody CYFN1006-1. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6u G J 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6u H K 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6u I L 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6u M P 0 F protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6u N Q 0 D protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6u O R 0 E protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer). Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6w G J 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Structure of EG.5.1 S trimer with 3 down-RBDs complex with antibody CYFN1006-2. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6w H K 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Structure of EG.5.1 S trimer with 3 down-RBDs complex with antibody CYFN1006-2. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6w I L 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Structure of EG.5.1 S trimer with 3 down-RBDs complex with antibody CYFN1006-2. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z6x B C 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of EG.5.1 RBD in complex with antibody CYFN1006-2. Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4, synthetic construct Wang, Y.J., Sun, L. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 8z74 A NA 0 C protein NA soluble cytochrome b562,apelin receptor SIGNALING PROTEIN 01/22/25 Cryo-EM structure of APJR complex with agonistic antibody Homo sapiens homo sapiens homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8z74 B NA 0 D protein NA soluble cytochrome b562,apelin receptor SIGNALING PROTEIN 01/22/25 Cryo-EM structure of APJR complex with agonistic antibody Homo sapiens homo sapiens homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8z86 H L 0 A protein NA spike protein s1 ALLERGEN/IMMUNE SYSTEM 02/12/25 BA.5 RBD in complex with CR9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8z95 A B 0 A Hapten PEU 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL IMMUNE SYSTEM 02/12/25 Humanized anti-PEG h6.3 Fab in complex with PEG Homo sapiens homo sapiens homo sapiens homo sapiens Lin, Y.C., Chang, C.Y., Su, Y.C. 2.26 X-RAY DIFFRACTION 0.261 0.209 False True IGHV7 IGKV4 Kappa None None None None None 8z95 H L 0 NA NA NA NA IMMUNE SYSTEM 02/12/25 Humanized anti-PEG h6.3 Fab in complex with PEG Homo sapiens homo sapiens homo sapiens Lin, Y.C., Chang, C.Y., Su, Y.C. 2.26 X-RAY DIFFRACTION 0.261 0.209 False True IGHV7 IGKV4 Kappa None None None None None 8zd1 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/26/25 Cryo-EM structure of the xGPR4-Gs complex in pH6.2 Homo sapiens; synthetic construct; Xenopus tropicalis synthetic construct homo sapiens | homo sapiens Rong, N.K., Wen, X., Yang, F., Sun, J.P. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zf6 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/26/25 Cryo-EM structure of the xGPR4-Gs complex in pH6.7 Homo sapiens; synthetic construct; Xenopus tropicalis synthetic construct homo sapiens | homo sapiens Rong, N.K., Wen, X., Yang, F., Sun, J.P. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zfa S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/26/25 Cryo-EM structure of the xtGPR4-Gs complex in pH7.2 Homo sapiens; synthetic construct; Xenopus tropicalis synthetic construct homo sapiens | homo sapiens Rong, N.K., Wen, X., Yang, F., Sun, J.P. 2.96 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zfc S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/26/25 Cryo-EM structure of the mmGPR4-Gs complex in pH7.6 Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Wen, X., Rong, N.K., Yang, F., Sun, J.P. 2.68 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zfz D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/22/25 cryo-EM structure of Gs-coupled zebrafish GPR4 at pH 6.5 Danio rerio; Escherichia coli; Homo sapiens; Mus musculus; synthetic construct mus musculus homo sapiens | homo sapiens Ma, Y., Tang, M., Ru, H., Song, G. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zjg S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/22/25 Cryo-EM structure of human CMKLR1-Gi complex bound to chemerin Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Liu, A.J., Liu, Y.Z., Ye, R.D. 3.18 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8znz F E 0 A protein NA 5'-nucleotidase IMMUNE SYSTEM 02/05/25 CD73 bound with HB0045 Homo sapiens homo sapiens homo sapiens homo sapiens Xu, J., Wan, L., He, Y. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8znz I J 0 A protein NA 5'-nucleotidase IMMUNE SYSTEM 02/05/25 CD73 bound with HB0045 Homo sapiens homo sapiens homo sapiens homo sapiens Xu, J., Wan, L., He, Y. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8znz D C 0 B protein NA 5'-nucleotidase IMMUNE SYSTEM 02/05/25 CD73 bound with HB0045 Homo sapiens homo sapiens homo sapiens homo sapiens Xu, J., Wan, L., He, Y. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8znz G H 0 B protein NA 5'-nucleotidase IMMUNE SYSTEM 02/05/25 CD73 bound with HB0045 Homo sapiens homo sapiens homo sapiens homo sapiens Xu, J., Wan, L., He, Y. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8zpn N NA 0 R protein NA soluble cytochrome b562,c-x-c chemokine receptor type 4 SIGNALING PROTEIN 02/26/25 Cryo-EM strucutre of CXCR4 complexed with antagonist AMD3100 Escherichia coli; Homo sapiens; Lama glama lama glama escherichia coli, homo sapiens Jiao, H.Z., Hu, H.L. 3.31 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9aru H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 01/29/25 COVA2-15 fragment antigen binding in complex with SARS-CoV-2 6P-mut7 S protein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9aru D F 0 B protein NA spike glycoprotein VIRAL PROTEIN 01/29/25 COVA2-15 fragment antigen binding in complex with SARS-CoV-2 6P-mut7 S protein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9aru E G 0 C protein NA spike glycoprotein VIRAL PROTEIN 01/29/25 COVA2-15 fragment antigen binding in complex with SARS-CoV-2 6P-mut7 S protein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9aug G J 0 A protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3.G57R Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9aug H K 0 B protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3.G57R Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9aug I L 0 C protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3.G57R Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9auh G J 0 A protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9auh H L 0 B protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9auh I K 0 C protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA3 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9aui G J 0 A protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA4 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9aui H K 0 B protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA4 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9aui I L 0 C protein NA hiv-1 bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/25 Cryo-EM structure of CH848.d949.10.17.GS-DH270.UCA4 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhang, Q.E., Acharya, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9avo B D 0 A protein NA histone chaperone asf1 IMMUNE SYSTEM/Chaperone 02/05/25 The crystal structure of an engineered Protein GD with Human Kappa Fab Homo sapiens; Streptococcus sp. 'group G' homo sapiens homo sapiens homo sapiens Slezak, T., Kossiakoff, A.A. 3 X-RAY DIFFRACTION 0.241 0.215 False True IGHV3 IGKV1 Kappa None None None None None 9awe B D 0 A protein NA histone chaperone asf1 IMMUNE SYSTEM 02/05/25 The crystal structure of an engineered Protein GF with Human Kappa Fab Homo sapiens; Streptococcus sp. 'group G' homo sapiens homo sapiens homo sapiens Slezak, T., Kossiakoff, A.A. 2.8 X-RAY DIFFRACTION 0.293 0.250 False True IGHV3 IGKV1 Kappa None None None None None 9b9k H L 0 A protein NA integrin alpha-5 light chain SIGNALING PROTEIN 02/05/25 Integrin alpha-5 beta-1 in complex with MINT1526A Fab Homo sapiens; unidentified unidentified unidentified homo sapiens Nguyen, A., Azumaya, C.M., Campbell, M.G. 2.7 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV3 Lambda None None None None None 9bdh H L 0 C protein NA gt10.2 VIRAL PROTEIN 02/19/25 Crystal structure of HIV-1 MPER scaffold in complex with antibody Fab Ab45.1 Mus musculus mus musculus mus musculus mus musculus Lee, C.C.D., Wilson, I.A. 3 X-RAY DIFFRACTION 0.290 0.269 False True IGHV1 IGKV3 Kappa None None None None None 9bdi C D 0 B protein NA gt10.2 glycan ko VIRAL PROTEIN 02/19/25 Crystal structure of HIV-1 MPER scaffold in complex with antibody Fab Ab45.2 Mus musculus mus musculus mus musculus mus musculus Lee, C.C.D., Wilson, I.A. 2.07 X-RAY DIFFRACTION 0.283 0.235 False True IGHV3 IGKV12 Kappa None None None None None 9bdi H L 0 A protein NA gt10.2 glycan ko VIRAL PROTEIN 02/19/25 Crystal structure of HIV-1 MPER scaffold in complex with antibody Fab Ab45.2 Mus musculus mus musculus mus musculus mus musculus Lee, C.C.D., Wilson, I.A. 2.07 X-RAY DIFFRACTION 0.283 0.235 False True IGHV3 IGKV12 Kappa None None None None None 9bhl N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/22/25 Human proton sensing receptor GPR65 in complex with miniGs Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Howard, M.K., Hoppe, N., Huang, X.P., Macdonald, C.B., Mehrotra, E., Rockefeller Grimes, P., Zahm, A.M., Trinidad, D.D., English, J., Coyote-Maestas, W., Manglik, A. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9bhm N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/22/25 Human proton sensing receptor GPR68 in complex with miniGs Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Howard, M.K., Hoppe, N., Huang, X.P., Macdonald, C.B., Mehrotra, E., Rockefeller Grimes, P., Zahm, A.M., Trinidad, D.D., English, J., Coyote-Maestas, W., Manglik, A. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9c0v H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Crystal structure of chimeric hemagglutinin cH5/1 in complex with broad protective antibody 3E1 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Nguyen, T.K.Y., Wilson, I.A. 3.5 X-RAY DIFFRACTION 0.321 0.292 False True IGHV4 IGKV1 Kappa None None None None None 9cqa E F 0 A peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Structure of antibody 1G1 bound to the central conserved region of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 1.74 X-RAY DIFFRACTION 0.225 0.211 False True IGHV1 IGLV3 Lambda None None None None None 9cqa D G 0 B peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Structure of antibody 1G1 bound to the central conserved region of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 1.74 X-RAY DIFFRACTION 0.225 0.211 False True IGHV1 IGLV3 Lambda None None None None None 9cqb B A 0 D peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 1G8 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.J., DuBois, M.J. 2.5 X-RAY DIFFRACTION 0.263 0.226 False True IGHV4 IGKV3 Kappa None None None None None 9cqd B F 0 T peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9cqd H G 0 A peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9cqd J I 0 j peptide NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9cqd L K 0 U peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9cqd P O 0 S peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9cqd R Q 0 N peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9cqd X W 0 M peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9cqd Z Y 0 V peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 02/19/25 Antibody 2B11 bound to the central conserved domain of RSV G Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Juarez, M.G., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.324 0.292 False True IGHV1 IGLV2 Lambda None None None None None 9crs J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9crs K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9ct0 J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-beta2-alpha2-gamma2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9ctj J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-beta3-alpha2-gamma2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9ctp J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-beta2-alpha3-gamma2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9ctv K L 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-gamma2-beta1-alpha2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9cx7 K L 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta3-alpha1-gamma2-beta3-alpha2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9cxb J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-beta1-alpha2-gamma2 assembly Homo sapiens; Mus musculus mus musculus homo sapiens homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9cxc K L 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta3-alpha1-gamma2-beta2-alpha2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9cxd J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Native human GABAA receptor of beta2-alpha1-beta1-beta1-gamma2 assembly Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9d6f H L 0 D protein NA type 1 fimbrin d-mannose specific adhesin fimh, donorstrand complemented with fimg peptide 'triple mutant' CELL ADHESION,SUGAR BINDING PROTEIN 02/05/25 Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 440-2 and 454-3 Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Lees, J.A., Han, S. 4.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 9d6f A C 0 D protein NA type 1 fimbrin d-mannose specific adhesin fimh, donorstrand complemented with fimg peptide 'triple mutant' CELL ADHESION,SUGAR BINDING PROTEIN 02/05/25 Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 440-2 and 454-3 Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Lees, J.A., Han, S. 4.24 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 9dm0 C D 0 B | G | A protein | protein | protein NA | NA | NA hemagglutinin | hemagglutinin | hemagglutinin IMMUNE SYSTEM 02/19/25 Cryo-EM structure of the SFV009 3G01 Fab in complex with A/California/04/2009 Homo sapiens; Influenza A virus (A/California/04/2009(H1N1)) homo sapiens homo sapiens influenza a virus (a/california/04/2009(h1n1)) | influenza a virus (a/california/04/2009(h1n1)) | influenza a virus (a/california/04/2009(h1n1)) Fernandez Quintero, M.L., Ferguson, J.A., Han, J., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9dng H L 0 A protein NA beta-arrestin-1,soluble cytochrome b562 SIGNALING PROTEIN/Immune System 01/22/25 Structure of rat beta-arrestin 1 by fiducial-assisted cryo-EM Homo sapiens; Rattus norvegicus homo sapiens homo sapiens rattus norvegicus Pakharukova, N., Kahsai, A.W., Masoudi, A., Lefkowitz, R.J. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dnm H L 0 A protein NA beta-arrestin-1,soluble cytochrome b562 SIGNALING PROTEIN/Immune System 01/22/25 Structure of rat beta-arrestin 1 bound to allosteric inhibitor Homo sapiens; Rattus norvegicus homo sapiens homo sapiens rattus norvegicus Pakharukova, N., Kahsai, A.W., Masoudi, A., Lefkowitz, R.J. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dq3 H L 0 C protein NA cytotoxic t-lymphocyte protein 4 ANTITUMOR PROTEIN/IMMUNE SYSTEM 02/05/25 Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with human CTLA-4 Homo sapiens homo sapiens homo sapiens homo sapiens Diong, S.J., Lee, P.S. 1.64 X-RAY DIFFRACTION 0.268 0.232 False True IGHV3 IGKV3 Kappa None None None None None 9dq4 H L 0 A protein NA cytotoxic t-lymphocyte protein 4 ANTITUMOR PROTEIN/IMMUNE SYSTEM 02/05/25 Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with mouse CTLA-4 Homo sapiens; Mus musculus homo sapiens homo sapiens mus musculus Diong, S.J., Lee, P.S. 1.57 X-RAY DIFFRACTION 0.233 0.205 False True IGHV3 IGKV3 Kappa None None None None None 9dq5 H L 0 C protein NA cytotoxic t-lymphocyte protein 4 ANTITUMOR PROTEIN/IMMUNE SYSTEM 02/05/25 Crystal structure of Anti-CTLA-4 Fab (9D9) in complex with mouse CTLA-4 Homo sapiens; Mus musculus homo sapiens homo sapiens mus musculus Lee, P.S., Diong, S.J., Robison, B. 3.1 X-RAY DIFFRACTION 0.301 0.239 False True IGHV1 IGKV1 Kappa None None None None None 9dq5 I M 0 D protein NA cytotoxic t-lymphocyte protein 4 ANTITUMOR PROTEIN/IMMUNE SYSTEM 02/05/25 Crystal structure of Anti-CTLA-4 Fab (9D9) in complex with mouse CTLA-4 Homo sapiens; Mus musculus homo sapiens homo sapiens mus musculus Lee, P.S., Diong, S.J., Robison, B. 3.1 X-RAY DIFFRACTION 0.301 0.239 False True IGHV1 IGKV1 Kappa None None None None None 9dq5 J N 0 NA NA NA NA ANTITUMOR PROTEIN/IMMUNE SYSTEM 02/05/25 Crystal structure of Anti-CTLA-4 Fab (9D9) in complex with mouse CTLA-4 Homo sapiens; Mus musculus homo sapiens homo sapiens Lee, P.S., Diong, S.J., Robison, B. 3.1 X-RAY DIFFRACTION 0.301 0.239 False True IGHV1 IGKV1 Kappa None None None None None 9drx J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 subtype in complex with GABA plus Lamotrigine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9drx K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/22/25 Human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 subtype in complex with GABA plus Lamotrigine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhou, J., Hibbs, R.E., Noviello, C.M. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9dvq G NA 0 A protein NA antiplasmin-cleaving enzyme fap, soluble form HYDROLASE 02/26/25 Cryo-EM structure of Human Fibroblast Activation Protein alpha dimer with one SUMO-I3 VHHs bound Homo sapiens; Lama glama lama glama homo sapiens Xu, Z., Schnicker, N.J., Wadas, T.J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9dvr G NA 0 A protein NA antiplasmin-cleaving enzyme fap, soluble form HYDROLASE 02/26/25 Cryo-EM structure of Human Fibroblast Activation Protein alpha dimer with two SUMO-I3 VHHs bound Homo sapiens; Lama glama lama glama homo sapiens Xu, Z., Schnicker, N.J., Wadas, T.J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9dvr H NA 0 B protein NA antiplasmin-cleaving enzyme fap, soluble form HYDROLASE 02/26/25 Cryo-EM structure of Human Fibroblast Activation Protein alpha dimer with two SUMO-I3 VHHs bound Homo sapiens; Lama glama lama glama homo sapiens Xu, Z., Schnicker, N.J., Wadas, T.J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9egn B NA 0 A peptide NA caveolae-associated protein 1 PROTEIN TRANSPORT 02/26/25 Crystal structure of the human Cavin1 HR1 domain bound to nanobody B7 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Collins, B.M., Gao, Y. 1.57 X-RAY DIFFRACTION 0.190 0.173 False True IGHV1 NA NA None None None None None 9eiu B NA 0 A peptide NA caveolae-associated protein 1 PROTEIN TRANSPORT 02/26/25 Crystal structure of the human Cavin1 HR1 TS/DD mutant domain bound to nanobody B7 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Collins, B.M., Gao, Y. 4 X-RAY DIFFRACTION 0.264 0.203 False True IGHV1 NA NA None None None None None 9fy8 B C 0 A carbohydrate A2G N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE SUGAR BINDING PROTEIN 02/12/25 L2A5 Fab in complex with STn-Thr Homo sapiens homo sapiens homo sapiens Laugieri, M.E., Ereno Orbea, J., Jimenez Barbero, J., Oyenarte, I. 2.62 X-RAY DIFFRACTION 0.306 0.248 False True IGHV3 IGKV4 Kappa None None None None None 9fy8 I L 0 NA NA NA NA SUGAR BINDING PROTEIN 02/12/25 L2A5 Fab in complex with STn-Thr Homo sapiens homo sapiens homo sapiens Laugieri, M.E., Ereno Orbea, J., Jimenez Barbero, J., Oyenarte, I. 2.62 X-RAY DIFFRACTION 0.306 0.248 False True IGHV3 IGKV4 Kappa None None None None None 9g6q H L 0 H Hapten RBR rocuronium IMMUNE SYSTEM 02/12/25 scFv IP11 in complex with rocuronium Mus musculus mus musculus mus musculus mus musculus Haouz, A., Saul, F.A., Bruhns, P. 1.2 X-RAY DIFFRACTION 0.189 0.168 True True IGHV1 IGKV2 Kappa None None None None None 9g6r H L 0 H Hapten RBR rocuronium IMMUNE SYSTEM 02/12/25 Fab-IP8 in complex with rocuronium Mus musculus mus musculus mus musculus mus musculus Haouz, A., Saul, F.A., Bruhns, P. 1.72 X-RAY DIFFRACTION 0.203 0.162 False True IGHV1 IGKV2 Kappa None None None None None 9g6s H L 0 H Hapten RBR rocuronium IMMUNE SYSTEM 02/12/25 Fab-IP2 in complex with rocuronium Mus musculus mus musculus mus musculus mus musculus Haouz, A., Saul, F.A., Bruhns, P. 2.373 X-RAY DIFFRACTION 0.253 0.208 False True IGHV1 IGKV4 Kappa None None None None None 9g95 B NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 nanobody in outward-facing conformation at 2.7552 A Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., El Omari, K., Lee, M., Naismith, J.H. 2.8 X-RAY DIFFRACTION 0.289 0.236 False True IGHV1 NA NA None None None None None 9g97 B NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 nanobody in outward-facing conformation at 0.9688 A Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., El Omari, K., Lee, M., Naismith, J.H. 2.31 X-RAY DIFFRACTION 0.260 0.214 False True IGHV1 NA NA None None None None None 9g9m B NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in outward-facing conformation - crystal 1 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.55 X-RAY DIFFRACTION 0.287 0.235 False True IGHV1 NA NA None None None None None 9g9m C NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in outward-facing conformation - crystal 1 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.55 X-RAY DIFFRACTION 0.287 0.235 False True IGHV1 NA NA None None None None None 9g9n B NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in inward-facing conformation - crystal 1 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.8 X-RAY DIFFRACTION 0.313 0.256 False True IGHV1 NA NA None None None None None 9g9n C NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in inward-facing conformation - crystal 1 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.8 X-RAY DIFFRACTION 0.313 0.256 False True IGHV1 NA NA None None None None None 9g9o B NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in outward-facing conformation - crystal 2 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.69 X-RAY DIFFRACTION 0.338 0.279 False True IGHV1 NA NA None None None None None 9g9o C NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in outward-facing conformation - crystal 2 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.69 X-RAY DIFFRACTION 0.338 0.279 False True IGHV1 NA NA None None None None None 9g9p B NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in inward-facing conformation - crystal 2 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.8 X-RAY DIFFRACTION 0.274 0.220 False True IGHV1 NA NA None None None None None 9g9p C NA 0 A protein NA lipid iii flippase TRANSPORT PROTEIN 01/22/25 Lipid III flippase WzxE with NB10 and NB7 nanobodies in inward-facing conformation - crystal 2 Escherichia coli; Lama glama lama glama escherichia coli Le Bas, A., Naismith, J.H. 2.8 X-RAY DIFFRACTION 0.274 0.220 False True IGHV1 NA NA None None None None None 9gox H L 0 A protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 IMMUNE SYSTEM 02/12/25 Crystal structure of Fab B6-D9 in complex with CD38 Homo sapiens homo sapiens homo sapiens homo sapiens Dreyfus, C., Freier, R. 1.84 X-RAY DIFFRACTION 0.208 0.174 False True IGHV1 IGKV3 Kappa None None None None None 9goy H L 0 A protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 IMMUNE SYSTEM 02/12/25 Crystal structure of Fab E2-RecA in complex with CD38 Homo sapiens homo sapiens homo sapiens homo sapiens Dreyfus, C., Fritz, G. 2.7 X-RAY DIFFRACTION 0.279 0.243 False True IGHV1 IGKV3 Kappa None None None None None 9ind H L 0 B protein NA integrin beta-8 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 Integrin alpha-v beta-8 in complex with the Fab of 130H2 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Sun, H., Zheng, Q., Gui, X. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9iv1 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/12/25 Identification, structure and agonist design of an androgen membrane receptor. Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Ping, Y.Q., Yang, Z. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9j1p N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/26/25 Cryo-EM structure of the g1:Ox-bound human GLP-1R-Gs complex Bos taurus; Homo sapiens; Lama glama; Rattus norvegicus; synthetic construct lama glama homo sapiens | rattus norvegicus Fan, S., Li, J., Zhuang, J., Zhou, Q., Mai, Y., Lin, B., Wang, M.-W., Wu, C. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9j31 D d 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/22/25 cryo-EM structure of zebrafish GPR4-Gs complex at pH 8.5 Danio rerio; Escherichia coli; Homo sapiens; Mus musculus; synthetic construct mus musculus homo sapiens | homo sapiens | homo sapiens Ma, Y.T., Tang, M.Y., Song, G.J., Ru, H. 3.05 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jnn E F 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native di-heteromeric GluN1-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 5.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9jnn G H 0 B protein NA glutamate receptor ionotropic, nmda 2b MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native di-heteromeric GluN1-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 5.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV19 Kappa None None None None None 9jnn I J 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native di-heteromeric GluN1-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 5.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9jnn K L 0 D protein NA glutamate receptor ionotropic, nmda 2b MEMBRANE PROTEIN/IMMUNE SYSTEM 02/05/25 Structure of native di-heteromeric GluN1-GluN2B NMDA receptor in rat cortex and hippocampus Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Zhang, M., Feng, J., Li, Y., Zhu, S. 5.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV19 Kappa None None None None None 9js4 B A 0 C protein NA spike glycoprotein VIRAL PROTEIN 01/22/25 Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD Homo heidelbergensis; Homo sapiens; Severe acute respiratory syndrome coronavirus homo heidelbergensis homo sapiens severe acute respiratory syndrome coronavirus Li, J., Li, H. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9jvg S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/26/25 Cryo-EM structure of the mmGPR4-Gs complex in pH6.2 Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Wen, X., Rong, N.K., Yang, F., Sun, J.P. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k26 S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PEPTIDE BINDING PROTEIN/IMMUNE SYSTEM 01/29/25 PrRP31 bound prolactin-releasing peptide receptor coupled with Gi protein complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Wu, Z., Du, Y., Chen, G. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9k27 D d 0 E | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PEPTIDE BINDING PROTEIN 01/29/25 PrRP31 bound prolactin-releasing peptide receptor coupled with Gq protein complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Wu, Z., Du, Y., Chen, G. 2.68 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9kt3 H K 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of EG.5.1 S trimer with 2 down-RBDs complex with antibody CYFN1006-2. Escherichia phage T4; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct escherichia phage t4 severe acute respiratory syndrome coronavirus2, escherichia phage t4, synthetic construct Wang, Y.J., Sun, L. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 9kt3 G J 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of EG.5.1 S trimer with 2 down-RBDs complex with antibody CYFN1006-2. Escherichia phage T4; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct escherichia phage t4 severe acute respiratory syndrome coronavirus2, escherichia phage t4, synthetic construct Wang, Y.J., Sun, L. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 9kt3 I L 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 01/29/25 Structure of EG.5.1 S trimer with 2 down-RBDs complex with antibody CYFN1006-2. Escherichia phage T4; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct escherichia phage t4 severe acute respiratory syndrome coronavirus2, escherichia phage t4, synthetic construct Wang, Y.J., Sun, L. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV2 Lambda None None None None None 9lae H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Locally refined region of SARS-CoV-2 spike in complex with antibodies 9G11 and 3E2. Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Jiang, Y., Sun, H., Zheng, Q., Li, S. 3.46 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 9lae A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/12/25 Locally refined region of SARS-CoV-2 spike in complex with antibodies 9G11 and 3E2. Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Jiang, Y., Sun, H., Zheng, Q., Li, S. 3.46 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 9ljj M NA 0 A protein NA heliorhodopsin MEMBRANE PROTEIN 02/12/25 cryo-EM structure of a nanobody bound heliorhodopsin Escherichia coli; Vicugna pacos vicugna pacos escherichia coli He, Y., Xia, R. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ljj N NA 0 B protein NA heliorhodopsin MEMBRANE PROTEIN 02/12/25 cryo-EM structure of a nanobody bound heliorhodopsin Escherichia coli; Vicugna pacos vicugna pacos escherichia coli He, Y., Xia, R. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9mi6 H L 0 A | B protein | protein NA | NA igg receptor fcrn large subunit p51 | beta-2-microglobulin IMMUNE SYSTEM 02/12/25 Crystal structure of human FcRn in complex with nipocalimab Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Xu, R., Meador, J. 2.41 X-RAY DIFFRACTION 0.248 0.206 False True IGHV3 IGLV2 Lambda None None None None None 9cq4 C D 0 F | G protein | protein NA | NA t-cell surface glycoprotein cd3 epsilon chain | t-cell surface glycoprotein cd3 gamma chain MEMBRANE PROTEIN/IMMUNE SYSTEM 01/15/25 G115 gamma delta TCR/CD3 complex bound by OKT3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Hoque, M., Saotome, K., Franklin, M.C. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9cq4 H L 0 E protein NA t-cell surface glycoprotein cd3 epsilon chain MEMBRANE PROTEIN/IMMUNE SYSTEM 01/15/25 G115 gamma delta TCR/CD3 complex bound by OKT3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hoque, M., Saotome, K., Franklin, M.C. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9cq7 H I 0 D | G protein | protein NA | NA g115 tcr delta chain | g115 tcr gamma chain MEMBRANE PROTEIN/IMMUNE SYSTEM 01/15/25 G115 TCR extracellular domain bound to Fab 1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Hoque, M., Saotome, K., Franklin, M.C. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9cq8 C E 0 A protein NA 9c2 tcr delta chain MEMBRANE PROTEIN/IMMUNE SYSTEM 01/15/25 Dimeric 9C2 gamma delta TCR extracellular domain bound by Fab 2 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hoque, M., Saotome, K., Franklin, M.C. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9cq8 G H 0 D protein NA 9c2 tcr delta chain MEMBRANE PROTEIN/IMMUNE SYSTEM 01/15/25 Dimeric 9C2 gamma delta TCR extracellular domain bound by Fab 2 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hoque, M., Saotome, K., Franklin, M.C. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9cql J K 0 E protein NA 9c2 tcr delta chain MEMBRANE PROTEIN 01/15/25 Dimeric 9C2 gamma delta TCR bound by Fab 3 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hoque, M., Saotome, K., Franklin, M.C. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9cql C D 0 A protein NA 9c2 tcr delta chain MEMBRANE PROTEIN 01/15/25 Dimeric 9C2 gamma delta TCR bound by Fab 3 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hoque, M., Saotome, K., Franklin, M.C. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8jzp H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/15/25 Structure of mouse C5a-human C5aR1-Go complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 3.45 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8rl5 K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 01/15/25 DNA helicase RECQL5 in complex with homo Di-Gluebody G5-006 Homo sapiens; Lama glama lama glama homo sapiens Yi, G., Ye, M., Mamalis, D., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rl5 L NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 01/15/25 DNA helicase RECQL5 in complex with homo Di-Gluebody G5-006 Homo sapiens; Lama glama lama glama homo sapiens Yi, G., Ye, M., Mamalis, D., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rl7 B NA 0 A protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 01/15/25 SPNS2 in complex with homo Di-Gluebody GbD12 Homo sapiens; Lama glama lama glama homo sapiens Yi, G., Ye, M., Mamalis, D., Li, H., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rl7 D NA 0 C protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 01/15/25 SPNS2 in complex with homo Di-Gluebody GbD12 Homo sapiens; Lama glama lama glama homo sapiens Yi, G., Ye, M., Mamalis, D., Li, H., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rl9 D NA 0 B protein NA green fluorescent protein HYDROLASE 01/15/25 RECQL5:sfGFP hetero dimer assembled by Di-Gluebody Aequorea victoria; Homo sapiens; Lama glama lama glama aequorea victoria Yi, G., Ye, M., Mamalis, D., Fairhead, M., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rl9 K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 01/15/25 RECQL5:sfGFP hetero dimer assembled by Di-Gluebody Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens Yi, G., Ye, M., Mamalis, D., Fairhead, M., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rla K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 01/15/25 RECQL5:sfGFP hetero dimer assembled by Di-Gluebody - RECQL5 local refinement Homo sapiens; Lama glama lama glama homo sapiens Yi, G., Ye, M., Mamalis, D., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rlb D NA 0 B protein NA green fluorescent protein HYDROLASE 01/15/25 RECQL5:sfGFP hetero dimer assembled by Di-Gluebody - sfGFP local refinement Aequorea victoria; Lama glama lama glama aequorea victoria Yi, G., Ye, M., Mamalis, D., Fairhead, M., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rlb K NA 0 NA NA NA NA HYDROLASE 01/15/25 RECQL5:sfGFP hetero dimer assembled by Di-Gluebody - sfGFP local refinement Aequorea victoria; Lama glama lama glama Yi, G., Ye, M., Mamalis, D., Fairhead, M., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rlc D NA 0 B protein NA green fluorescent protein MEMBRANE PROTEIN 01/15/25 SPNS2:sfGFP hetero dimer assembled by Di-Gluebody Aequorea victoria; Homo sapiens; Lama glama lama glama aequorea victoria Yi, G., Ye, M., Mamalis, D., Li, H., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rlc C NA 0 A protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 01/15/25 SPNS2:sfGFP hetero dimer assembled by Di-Gluebody Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens Yi, G., Ye, M., Mamalis, D., Li, H., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rle D NA 0 B protein NA green fluorescent protein HYDROLASE 01/15/25 SPNS2:sfGFP hetero dimer assembled by Di-Gluebody - sfGFP local refinement Aequorea victoria; Lama glama lama glama aequorea victoria Yi, G., Ye, M., Mamalis, D., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rle C NA 0 NA NA NA NA HYDROLASE 01/15/25 SPNS2:sfGFP hetero dimer assembled by Di-Gluebody - sfGFP local refinement Aequorea victoria; Lama glama lama glama Yi, G., Ye, M., Mamalis, D., Sauer, D.B., von Delft, F., Davis, B.G., Gilbert, R.J.C. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8vvf E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/15/25 Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Gati, C., Motiwala, Z., Tyson, A.S., Styrpejko, D., Han, G.W., Khan, S., Ramos-Gonzalez, N., Shenvi, R., Majumdar, S. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8w3r A a 0 F protein NA prefusion-stabilized rsv f protein ufcr2-iss-p2-nq VIRAL PROTEIN 01/15/25 Crystal structure of prefusion-stabilized RSV F protein UFCR2-iSS-P2-NQ in complex with A4 single-chain fragment variable Homo sapiens homo sapiens homo sapiens Lee, Y.Z., Stanfield, R.L., Wilson, I.A., Zhu, J. 4.02 X-RAY DIFFRACTION 0.303 0.249 True True unknown unknown unknown None None None None None 8xs1 H L 0 A peptide NA osteocalcin IMMUNE SYSTEM 01/15/25 Crystal structure of Fab fragment of anti-osteocalcin antibody KTM219 complexed with C-terminal peptide antigen Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Komatsu, M., Dong, J., Ueda, H., Arai, R. 2.3 X-RAY DIFFRACTION 0.248 0.199 False True IGHV1 IGKV1 Kappa None None None None None 8xs2 H L 0 NA NA NA NA IMMUNE SYSTEM 01/15/25 Crystal structure of Fab fragment of anti-osteocalcin C-terminal peptide antibody KTM219 with addition of fluorophore TAMRA Mus musculus mus musculus mus musculus Yazaki, S., Ueda, H., Arai, R. 2.14 X-RAY DIFFRACTION 0.244 0.202 False True IGHV1 IGKV1 Kappa None None None None None 8xt9 A NA 0 C protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 01/15/25 structure of LGR4 Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xum C NA 0 A protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 01/15/25 Structure of LGR4 with RSPO2 Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xx3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/15/25 Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R. 3.38 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xx6 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/15/25 Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R. 2.99 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xxh S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/15/25 Structure of CXCR2 bound to CXCL2 (CXCR2-CXCL2-Go Full map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xxr S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/15/25 Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R. 3.17 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xxx S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/15/25 Structure of CXCR2 bound to CXCL6 (Composite map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R. 3.17 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9bi6 N NA 0 A | B protein | protein NA | NA minigsq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/15/25 Human proton sensing receptor GPR68 in complex with miniGsq Homo sapiens; Lama glama; synthetic construct lama glama synthetic construct | homo sapiens Howard, M.K., Hoppe, N., Huang, X.P., Macdonald, C.B., Mehrotra, E., Rockefeller Grimes, P., Zahm, A.M., Trinidad, D.D., English, J., Coyote-Maestas, W., Manglik, A. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9bip N NA 0 A | B protein | protein NA | NA minigs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/15/25 Human proton sensing receptor GPR4 in complex with miniGs Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Howard, M.K., Hoppe, N., Huang, X.P., Macdonald, C.B., Mehrotra, E., Rockefeller Grimes, P., Zahm, A.M., Trinidad, D.D., English, J., Coyote-Maestas, W., Manglik, A. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9blx H L 0 G peptide NA envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 01/15/25 Rhesus macaque ITS111.01 Fab in complex with SIV MPER peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Ahmadi, M., Kwong, P.D. 1.96 X-RAY DIFFRACTION 0.204 0.178 False True IGHV4 IGKV1 Kappa None None None None None 9blx A B 0 I peptide NA envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 01/15/25 Rhesus macaque ITS111.01 Fab in complex with SIV MPER peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Ahmadi, M., Kwong, P.D. 1.96 X-RAY DIFFRACTION 0.204 0.178 False True IGHV4 IGKV1 Kappa None None None None None 9bns H L 0 C peptide NA mper peptide IMMUNE SYSTEM 01/15/25 Rhesus macaque ITS114.01 Fab in complex with SIV MPER peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Lai, Y.-T., Kwong, P.D. 3 X-RAY DIFFRACTION 0.271 0.228 False True IGHV4 IGKV1 Kappa None None None None None 9bns A B 0 D peptide NA mper peptide IMMUNE SYSTEM 01/15/25 Rhesus macaque ITS114.01 Fab in complex with SIV MPER peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Lai, Y.-T., Kwong, P.D. 3 X-RAY DIFFRACTION 0.271 0.228 False True IGHV4 IGKV1 Kappa None None None None None 9bp1 A B 0 I peptide NA envelope glycoprotein gp160 IMMUNE SYSTEM/Viral protein 01/15/25 Rhesus macaque ITS110.01 Fab in complex with SIV Env MPER peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Kwong, P.D. 3.58 X-RAY DIFFRACTION 0.268 0.220 False True IGHV4 IGKV1 Kappa None None None None None 9bp1 H D 0 E peptide NA envelope glycoprotein gp160 IMMUNE SYSTEM/Viral protein 01/15/25 Rhesus macaque ITS110.01 Fab in complex with SIV Env MPER peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Kwong, P.D. 3.58 X-RAY DIFFRACTION 0.268 0.220 False True IGHV4 IGKV1 Kappa None None None None None 9hk1 H L 0 A protein NA programmed cell death protein 1 IMMUNOSUPPRESSANT 01/15/25 PD1 signaling receptor bound to FAB Complex Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Bjorkelid, C., Paluch, C., Robertson, N.J. 2.03 X-RAY DIFFRACTION 0.276 0.210 False True IGHV1 IGKV1 Kappa None None None None None 9hk1 I M 0 B protein NA programmed cell death protein 1 IMMUNOSUPPRESSANT 01/15/25 PD1 signaling receptor bound to FAB Complex Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Bjorkelid, C., Paluch, C., Robertson, N.J. 2.03 X-RAY DIFFRACTION 0.276 0.210 False True IGHV1 IGKV1 Kappa None None None None None 9itb N NA 0 A | B protein | protein NA | NA engineered minigaq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/15/25 LPA-bound LPAR6 in complex with miniGq Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Duan, Y. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ite E e 0 A | B protein | protein NA | NA engineered miniga13 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/15/25 LPA-bound LPAR6 in complex with miniG13 Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Duan, Y. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9j7y H NA 0 G protein NA entry-fusion complex associated protein opg095 VIRAL PROTEIN/IMMUNE SYSTEM 01/15/25 the complex structure of MPXV M1R and nanobody M1R-01 Monkeypox virus; synthetic construct synthetic construct monkeypox virus Ge, J.W., Fan, M. 2.59 X-RAY DIFFRACTION 0.270 0.226 False True IGHV1 NA NA None None None None None 9mmv H L 0 NA NA NA NA IMMUNE SYSTEM 01/15/25 RB1 Fab bound to 1D4 anti-idiotype Fab Homo sapiens homo sapiens homo sapiens Warren, C. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 9mmv M N 0 NA NA NA NA IMMUNE SYSTEM 01/15/25 RB1 Fab bound to 1D4 anti-idiotype Fab Homo sapiens homo sapiens homo sapiens Warren, C. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8zhq D A 0 E protein NA envelopment polyprotein VIRAL PROTEIN 01/08/25 SFTSV Gn in complex with JK-8/12 Fab Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Shang, H., Guo, Y., Zhang, N., Liu, W., Li, H. 2.37 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV3 Lambda None None None None None 8zhq C B 0 E protein NA envelopment polyprotein VIRAL PROTEIN 01/08/25 SFTSV Gn in complex with JK-8/12 Fab Homo sapiens; Severe fever with thrombocytopenia syndrome virus homo sapiens homo sapiens severe fever with thrombocytopenia syndromevirus Shang, H., Guo, Y., Zhang, N., Liu, W., Li, H. 2.37 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9mml H L 0 NA NA NA NA IMMUNE SYSTEM 01/08/25 RB1 Fab bound to 1A6 anti-idiotype Fab Homo sapiens homo sapiens homo sapiens Warren, C. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9mml M N 0 NA NA NA NA IMMUNE SYSTEM 01/08/25 RB1 Fab bound to 1A6 anti-idiotype Fab Homo sapiens homo sapiens homo sapiens Warren, C. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xml S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 01/01/25 Cryo-EM structure of the Apo CCR8-Gi complex Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Peng, Q., Jiang, H.H., Cheng, X.Y., Li, J., Zhang, J. 2.58 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zr4 A B 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 01/01/25 Cryo-EM structure of the N2-4N2C402 complex at a resolution of 1.9 angstrom Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Chu, B.X., Wang, X., Yang, Q., Wu, X.D., Zhang, Z.L. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8zr4 F G 0 H protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 01/01/25 Cryo-EM structure of the N2-4N2C402 complex at a resolution of 1.9 angstrom Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Chu, B.X., Wang, X., Yang, Q., Wu, X.D., Zhang, Z.L. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8zr4 I J 0 K protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 01/01/25 Cryo-EM structure of the N2-4N2C402 complex at a resolution of 1.9 angstrom Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Chu, B.X., Wang, X., Yang, Q., Wu, X.D., Zhang, Z.L. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8zr4 L M 0 N protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 01/01/25 Cryo-EM structure of the N2-4N2C402 complex at a resolution of 1.9 angstrom Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Chu, B.X., Wang, X., Yang, Q., Wu, X.D., Zhang, Z.L. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9fqo A B 0 NA NA NA NA IMMUNE SYSTEM 01/01/25 Crystal structure of C0083 Fab targeting the oxidized macrophage migration inhibitory factor (oxMIF) Homo sapiens homo sapiens homo sapiens Rossmueller, G., Mirkina, I., Thiele, M., Puchol Tarazona, A.A., Rueker, F., Kerschbaumer, R.J., Schinagl, A. 1.7 X-RAY DIFFRACTION 0.237 0.215 False True IGHV3 IGKV1 Kappa None None None None None 9h76 B NA 0 A protein NA putative amino acid/polyamine transport protein MEMBRANE PROTEIN 01/01/25 Bacterial LAT transporter BASC in complex with L-Ala and NB53 Carnobacterium sp. AT7; Lama glama lama glama carnobacterium sp. at7 Fort, J., Palacin, M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9iy8 S s 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein subunit alpha-13 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 01/01/25 Cryo-EM structure of apo-GPR55-G13 complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Hua, T., Liu, Z.J., Cherezov, V., Chang, H., Li, X.T., Shen, L. 3.01 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9izh S s 0 A | B | C protein | protein | protein NA | NA | NA g protein subunit 13 (gi2-mini-g13 chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 01/01/25 Cryo-EM structure of LPA1-G13 complex with LPA Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens | mus musculus Suzuki, S., Nishikawa, K., Kamegawa, A., Hiroaki, Y., Suzuki, H., Fujiyoshi, Y. 3.04 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9l1s C B 0 A protein NA receptor tyrosine-protein kinase erbb-2 IMMUNE SYSTEM 01/01/25 Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex Homo sapiens homo sapiens homo sapiens homo sapiens Xu, L., Guo, J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8t6m B A 0 E protein NA mhc class i antigen IMMUNE SYSTEM 12/25/24 Human leukocyte antigen bound by two alloreactive antibody Fabs Homo sapiens homo sapiens homo sapiens homo sapiens Kizziah, J.L., Killian, J.T., Diaz-Avalos, R., Qiu, S., Yang, G., Green, T., Lund, F.E. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8t6m D C 0 E | G protein | peptide NA | NA mhc class i antigen | hla_a0101_peptide IMMUNE SYSTEM 12/25/24 Human leukocyte antigen bound by two alloreactive antibody Fabs Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Kizziah, J.L., Killian, J.T., Diaz-Avalos, R., Qiu, S., Yang, G., Green, T., Lund, F.E. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8t7r B A 0 C | 0 protein | peptide NA | NA mhc class i antigen (fragment) | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8t7r F E 0 G | 1 protein | peptide NA | NA mhc class i antigen (fragment) | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8t7r J I 0 K | 2 protein | peptide NA | NA mhc class i antigen (fragment) | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8t7r N M 0 O | 3 protein | peptide NA | NA mhc class i antigen (fragment) | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8t7r R Q 0 S | 4 protein | peptide NA | NA mhc class i antigen (fragment) | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8t7r V U 0 W | 5 protein | peptide NA | NA mhc class i antigen (fragment) | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8t7r Z Y 0 a | 6 protein | peptide NA | NA unknown | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8t7r d c 0 e | 7 protein | peptide NA | NA unknown | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False False IGHV3 IGLV3 Lambda None None None None None 8t7r h g 0 i | 8 protein | peptide NA | NA unknown | peptide IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | cytomegalovirus Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False False IGHV3 IGLV3 Lambda None None None None None 8t7r l k 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False False IGHV3 IGLV3 Lambda None None None None None 8t7r p o 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False False IGHV3 IGLV3 Lambda None None None None None 8t7r t s 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 Crystal structure of human leukocyte antigen A*0101 in complex with the Fab of alloreactive antibody E07 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Green, T.J., Killian Jr, J.T., Qiu, S., Macon, K.J., Yang, G., King, R.G., Lund, F.E. 3.84 X-RAY DIFFRACTION 0.263 0.217 False False IGHV3 IGLV3 Lambda None None None None None 8qgx B NA 0 A protein NA neutrophil elastase HYDROLASE 12/25/24 Complex between human neutrophil elastase with nanobody NbE201 Homo sapiens; Lama glama lama glama homo sapiens Morales-Yanez, F., Redeghieri, P., Moray, J., Dumoulin, M., Kerff, F. 2.3 X-RAY DIFFRACTION 0.271 0.224 False True IGHV1 NA NA None None None None None 8qgz B NA 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 NbE201 a nanobody binding human neutrophil elastase Lama glama lama glama Redeghieri, P., Morales-Yanez, F., Moray, J., Dumoulin, M., Kerff, F. 1.8 X-RAY DIFFRACTION 0.254 0.217 False True IGHV1 NA NA None None None None None 8qgz A NA 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 NbE201 a nanobody binding human neutrophil elastase Lama glama lama glama Redeghieri, P., Morales-Yanez, F., Moray, J., Dumoulin, M., Kerff, F. 1.8 X-RAY DIFFRACTION 0.254 0.217 False True IGHV1 NA NA None None None None None 8qgz C NA 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 NbE201 a nanobody binding human neutrophil elastase Lama glama lama glama Redeghieri, P., Morales-Yanez, F., Moray, J., Dumoulin, M., Kerff, F. 1.8 X-RAY DIFFRACTION 0.254 0.217 False True IGHV1 NA NA None None None None None 8qgz D NA 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 NbE201 a nanobody binding human neutrophil elastase Lama glama lama glama Redeghieri, P., Morales-Yanez, F., Moray, J., Dumoulin, M., Kerff, F. 1.8 X-RAY DIFFRACTION 0.254 0.217 False True IGHV1 NA NA None None None None None 8shv H L 0 NA NA NA NA IMMUNE SYSTEM 12/25/24 38B7 unliganded Homo sapiens homo sapiens homo sapiens Spiller, B.W., Shrem, R.A. 1.58 X-RAY DIFFRACTION 0.178 0.164 False True IGHV3 IGKV3 Kappa None None None None None 8shw H L 0 Q peptide NA conglutin-7 IMMUNE SYSTEM 12/25/24 38B7 with hydroxy-proline peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 1.95 X-RAY DIFFRACTION 0.205 0.178 False True IGHV3 IGKV3 Kappa None None None None None 8shw C A 0 B peptide NA conglutin-7 IMMUNE SYSTEM 12/25/24 38B7 with hydroxy-proline peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 1.95 X-RAY DIFFRACTION 0.205 0.178 False True IGHV3 IGKV3 Kappa None None None None None 8si1 H L 0 E protein NA conglutin IMMUNE SYSTEM 12/25/24 Ara h 6 16A8 complex Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 3.2 X-RAY DIFFRACTION 0.300 0.247 False True IGHV1 IGLV3 Lambda None None None None None 8si1 B A 0 F protein NA conglutin IMMUNE SYSTEM 12/25/24 Ara h 6 16A8 complex Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 3.2 X-RAY DIFFRACTION 0.300 0.247 False True IGHV1 IGLV3 Lambda None None None None None 8si1 D C 0 G protein NA conglutin IMMUNE SYSTEM 12/25/24 Ara h 6 16A8 complex Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 3.2 X-RAY DIFFRACTION 0.300 0.247 False True IGHV1 IGLV3 Lambda None None None None None 8sj4 H L 0 A protein NA conglutin IMMUNE SYSTEM 12/25/24 8F3-1H9-Ara h 6 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 2.67 X-RAY DIFFRACTION 0.232 0.190 False True IGHV7 IGKV1 Kappa None None None None None 8sj4 F D 0 A protein NA conglutin IMMUNE SYSTEM 12/25/24 8F3-1H9-Ara h 6 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 2.67 X-RAY DIFFRACTION 0.232 0.190 False True IGHV4 IGKV3 Kappa None None None None None 8sj6 C D 0 Q protein NA ara h 2 allergen IMMUNE SYSTEM 12/25/24 Ara h 2.01 38B7 8F3 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 3.97 X-RAY DIFFRACTION 0.302 0.252 False True IGHV4 IGKV3 Kappa None None None None None 8sj6 A B 0 Q protein NA ara h 2 allergen IMMUNE SYSTEM 12/25/24 Ara h 2.01 38B7 8F3 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 3.97 X-RAY DIFFRACTION 0.302 0.252 False True IGHV3 IGKV3 Kappa None None None None None 8sja H L 0 G protein NA conglutin IMMUNE SYSTEM 12/25/24 Ara H 6 13D9 16A8 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 2.68 X-RAY DIFFRACTION 0.239 0.194 False True IGHV1 IGLV3 Lambda None None None None None 8sja B A 0 I protein NA conglutin IMMUNE SYSTEM 12/25/24 Ara H 6 13D9 16A8 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 2.68 X-RAY DIFFRACTION 0.239 0.194 False True IGHV1 IGLV3 Lambda None None None None None 8sja D C 0 G protein NA conglutin IMMUNE SYSTEM 12/25/24 Ara H 6 13D9 16A8 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 2.68 X-RAY DIFFRACTION 0.239 0.194 False True IGHV3 IGLV3 Lambda None None None None None 8sja F E 0 I protein NA conglutin IMMUNE SYSTEM 12/25/24 Ara H 6 13D9 16A8 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Spiller, B.W., Shrem, R.A. 2.68 X-RAY DIFFRACTION 0.239 0.194 False True IGHV3 IGLV3 Lambda None None None None None 8ume H L 0 C protein NA hemagglutinin VIRAL PROTEIN 12/25/24 Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 8ume D F 0 A protein NA hemagglutinin VIRAL PROTEIN 12/25/24 Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 8ume E G 0 B protein NA hemagglutinin VIRAL PROTEIN 12/25/24 Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 8ybl B NA 0 A protein NA enterotoxin type b ANTITOXIN 12/25/24 Crystal structure of nanobody SEB-Nb3 bound to staphylococcal enterotoxin B (SEB) Staphylococcus aureus; Vicugna pacos vicugna pacos staphylococcus aureus Ding, Y., Zong, X., Liu, R., Liu, P. 2.33 X-RAY DIFFRACTION 0.262 0.223 False True IGHV1 NA NA None None None None None 8ybm B NA 0 A protein NA enterotoxin type b ANTITOXIN 12/25/24 Crystal structure of nanobody SEB-Nb6 bound to staphylococcal enterotoxin B (SEB) Staphylococcus aureus; Vicugna pacos vicugna pacos staphylococcus aureus Ding, Y., Zong, X., Liu, R., Liu, P. 2.04 X-RAY DIFFRACTION 0.259 0.213 False True IGHV1 NA NA None None None None None 8ybm D NA 0 C protein NA enterotoxin type b ANTITOXIN 12/25/24 Crystal structure of nanobody SEB-Nb6 bound to staphylococcal enterotoxin B (SEB) Staphylococcus aureus; Vicugna pacos vicugna pacos staphylococcus aureus Ding, Y., Zong, X., Liu, R., Liu, P. 2.04 X-RAY DIFFRACTION 0.259 0.213 False True IGHV1 NA NA None None None None None 8ybn B NA 0 A protein NA enterotoxin type b ANTITOXIN 12/25/24 Crystal structure of nanobody SEB-Nb8 bound to staphylococcal enterotoxin B (SEB) Staphylococcus aureus; Vicugna pacos vicugna pacos staphylococcus aureus Ding, Y., Zong, X., Liu, R., Liu, P. 2.18 X-RAY DIFFRACTION 0.281 0.232 False True IGHV1 NA NA None None None None None 8ybo B NA 0 A protein NA enterotoxin type b ANTITOXIN 12/25/24 Crystal structure of nanobody SEB-Nb11 bound to staphylococcal enterotoxin B (SEB) Staphylococcus aureus; Vicugna pacos vicugna pacos staphylococcus aureus Ding, Y., Zong, X., Liu, R., Liu, P. 1.59 X-RAY DIFFRACTION 0.284 0.261 False True IGHV3 NA NA None None None None None 8ybo D NA 0 C protein NA enterotoxin type b ANTITOXIN 12/25/24 Crystal structure of nanobody SEB-Nb11 bound to staphylococcal enterotoxin B (SEB) Staphylococcus aureus; Vicugna pacos vicugna pacos staphylococcus aureus Ding, Y., Zong, X., Liu, R., Liu, P. 1.59 X-RAY DIFFRACTION 0.284 0.261 False True IGHV3 NA NA None None None None None 8ybp B NA 0 A protein NA enterotoxin type b ANTITOXIN 12/25/24 Crystal structure of nanobody SEB-Nb20 bound to staphylococcal enterotoxin B (SEB) Staphylococcus aureus; Vicugna pacos vicugna pacos staphylococcus aureus Ding, Y., Zong, X., Liu, R., Liu, P. 2.08 X-RAY DIFFRACTION 0.253 0.220 False True IGHV1 NA NA None None None None None 8zpp H L 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 12/25/24 Local CryoEM structure of the SARS-CoV-2 BA.5 in complex with ORB10 Fab Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cao, S., Leng, C., Hu, H. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 9c7d H L 0 B peptide NA circumsporozoite protein IMMUNE SYSTEM 12/25/24 Human monoclonal antibody MAD22-38 bound to the N-terminus of cleaved circumsporozoite protein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Moskovitz, R., Wilson, I.A. 1.99 X-RAY DIFFRACTION 0.232 0.184 False True IGHV4 IGKV1 Kappa None None None None None 9c7f H L 0 J peptide NA circumsporozoite protein IMMUNE SYSTEM 12/25/24 Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Moskovitz, R., Wilson, I.A. 1.82 X-RAY DIFFRACTION 0.238 0.211 False True IGHV3 IGKV3 Kappa None None None None None 9c7f A B 0 G peptide NA circumsporozoite protein IMMUNE SYSTEM 12/25/24 Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Moskovitz, R., Wilson, I.A. 1.82 X-RAY DIFFRACTION 0.238 0.211 False True IGHV3 IGKV3 Kappa None None None None None 9c7f C D 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 12/25/24 Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Moskovitz, R., Wilson, I.A. 1.82 X-RAY DIFFRACTION 0.238 0.211 False True IGHV3 IGKV3 Kappa None None None None None 9c7f E F 0 Q peptide NA circumsporozoite protein IMMUNE SYSTEM 12/25/24 Human monoclonal antibody MAD24-01 bound to the N-terminus of cleaved circumsporozoite protein Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Moskovitz, R., Wilson, I.A. 1.82 X-RAY DIFFRACTION 0.238 0.211 False True IGHV3 IGKV3 Kappa None None None None None 9cbn A B 0 C protein NA structural protein VIRAL PROTEIN/IMMUNE SYSTEM 12/25/24 HAstV1 spike in complex with neutralizing Fabs 3H4 and 3B4 Human astrovirus 1; Mus musculus mus musculus mus musculus human astrovirus 1 Lanning, S., DuBois, R.M., Balasco Serrao, V.H. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 9cbn E F 0 D protein NA structural protein VIRAL PROTEIN/IMMUNE SYSTEM 12/25/24 HAstV1 spike in complex with neutralizing Fabs 3H4 and 3B4 Human astrovirus 1; Mus musculus mus musculus mus musculus human astrovirus 1 Lanning, S., DuBois, R.M., Balasco Serrao, V.H. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 9cbn G H 0 C protein NA structural protein VIRAL PROTEIN/IMMUNE SYSTEM 12/25/24 HAstV1 spike in complex with neutralizing Fabs 3H4 and 3B4 Human astrovirus 1; Mus musculus mus musculus mus musculus human astrovirus 1 Lanning, S., DuBois, R.M., Balasco Serrao, V.H. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 9cn2 B b 0 A protein NA spike protein VIRAL PROTEIN 12/25/24 Human astrovirus 2 spike bound to neutralizing scFv 4B6 Human astrovirus 2; Mus musculus mus musculus human astrovirus 2 Lanning, S., DuBois, R.M. 2.67 X-RAY DIFFRACTION 0.259 0.212 True True unknown unknown unknown None None None None None 9d3d H L 0 C | B | A protein | protein | protein NA | NA | NA bg505 ds-sosip glycoprotein gp41 | bg505 ds-sosip glycoprotein gp41 | bg505 ds-sosip glycoprotein gp41 VIRAL PROTEIN 12/25/24 Cryo-EM structure of PGT145 R100aS Fab bound to HIV-1 BG505 DS-SOSIP.664 Env trimer Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Hodges, S., Morano, N.C., Shapiro, L., Kwong, P.D., Gorman, J. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8s6z A B 0 C protein NA t-cell-specific surface glycoprotein cd28 IMMUNE SYSTEM 12/18/24 CD28 in complex with the antibody Fab fragment AI3 Homo sapiens homo sapiens homo sapiens homo sapiens Majocchi, S., Giovanni, M., Malinge, P., Fischer, N., Svensson, L.A., Kelpsas, V., Rose, N.C. 3.05 X-RAY DIFFRACTION 0.258 0.198 False True IGHV3 IGKV4 Kappa None None None None None 8s6z D E 0 F protein NA t-cell-specific surface glycoprotein cd28 IMMUNE SYSTEM 12/18/24 CD28 in complex with the antibody Fab fragment AI3 Homo sapiens homo sapiens homo sapiens homo sapiens Majocchi, S., Giovanni, M., Malinge, P., Fischer, N., Svensson, L.A., Kelpsas, V., Rose, N.C. 3.05 X-RAY DIFFRACTION 0.258 0.198 False True IGHV3 IGKV4 Kappa None None None None None 8v9d I J 0 B | A protein | protein NA | NA aquaporin-4 | aquaporin-4 TRANSPORT PROTEIN/IMMUNE SYSTEM 12/11/24 Structure of human AQP4 with a pathogenic autoantibody - rAB 186 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Gupta, M., Khandelwal, N.K., Stroud, R.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8v9d K L 0 C protein NA aquaporin-4 TRANSPORT PROTEIN/IMMUNE SYSTEM 12/11/24 Structure of human AQP4 with a pathogenic autoantibody - rAB 186 Homo sapiens homo sapiens homo sapiens homo sapiens Gupta, M., Khandelwal, N.K., Stroud, R.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8v9d M N 0 D protein NA aquaporin-4 TRANSPORT PROTEIN/IMMUNE SYSTEM 12/11/24 Structure of human AQP4 with a pathogenic autoantibody - rAB 186 Homo sapiens homo sapiens homo sapiens homo sapiens Gupta, M., Khandelwal, N.K., Stroud, R.M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 9b2m H L 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 Hemagglutinin H1 New Caledonia 1999 in complex with monoclonal antibody Fab 43_S0008 Influenza A virus; Mus sp. mus sp. mus sp. influenza a virus | influenza a virus Torrents de la Pena, A., de Paiva Froes Rocha, R., Ward, A.B., Ataca, S., Kanekiyo, M. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9b2m E F 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 Hemagglutinin H1 New Caledonia 1999 in complex with monoclonal antibody Fab 43_S0008 Influenza A virus; Mus sp. mus sp. mus sp. influenza a virus | influenza a virus Torrents de la Pena, A., de Paiva Froes Rocha, R., Ward, A.B., Ataca, S., Kanekiyo, M. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9b2m J K 0 I | G protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 Hemagglutinin H1 New Caledonia 1999 in complex with monoclonal antibody Fab 43_S0008 Influenza A virus; Mus sp. mus sp. mus sp. influenza a virus | influenza a virus Torrents de la Pena, A., de Paiva Froes Rocha, R., Ward, A.B., Ataca, S., Kanekiyo, M. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8jag H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/18/24 Cryo-EM structure of SARS-CoV-1 RBD in complex with W328-6H2 (local refinement) Homo sapiens; Severe acute respiratory syndrome-related coronavirus homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Nan, X.Y., Li, Y.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV2 Kappa None None None None None 8jam H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/18/24 Cryo-EM structure of Omicron BA.1 RBD in complex with W328-6H2 (local refinement) Homo sapiens; Severe acute respiratory syndrome-related coronavirus homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Nan, X.Y., Li, Y.J. 3.92 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV2 Kappa None None None None None 8jap H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/18/24 Cryo-EM structure of SARS-CoV-2 WT RBD in complex with W328-6H2 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Nan, X.Y., Li, Y.J. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV2 Kappa None None None None None 8jef S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/18/24 Cryo-EM Structure of the 3HO-HCAR3-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Fang, Y., Pan, X. 2.96 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jkf H L 0 A protein NA ns1 VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 CryoEM structure of sNS1 complexed with Fab 3G2 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jkf h l 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 CryoEM structure of sNS1 complexed with Fab 3G2 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.83 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 8jkf M N 0 B protein NA ns1 VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 CryoEM structure of sNS1 complexed with Fab 3G2 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jkf m n 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 CryoEM structure of sNS1 complexed with Fab 3G2 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.83 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 8jqm H L 0 A protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 12/18/24 CryoEM structure of sNS1 complexed with Fab 4F10 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8jqm M N 0 B protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 12/18/24 CryoEM structure of sNS1 complexed with Fab 4F10 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8jqn H L 0 A protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 CryoEM structure of sNS1 complexed with Fab 2E11 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8jqn h l 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 CryoEM structure of sNS1 complexed with Fab 2E11 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Qi, P. 2.8 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV3 Lambda None None None None None 8rby B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 12/11/24 The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.26 Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Fernandez, L.A., Silva, K. 1.9 X-RAY DIFFRACTION 0.234 0.187 False True IGHV1 NA NA None None None None None 8v5q H L 0 G protein NA envelope glycoprotein e VIRAL PROTEIN 12/11/24 Varicella Zoster Virus (VZV) glycoprotein E (gE) gI binding domain in complex with human Fab 1E3 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Holzapfel, G., Seraj, N., Harshbarger, W. 1.9 X-RAY DIFFRACTION 0.233 0.226 False True IGHV4 IGKV1 Kappa None None None None None 8v5v b d 0 E protein NA variable domain of the light chain from the human antibody6c10 VIRAL PROTEIN 12/18/24 Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Olmedillas, E., Diaz, R., Hastie, K., Ollmann-Saphire, E. 2.93 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 8v5v f g 0 G protein NA variable domain of the light chain from the human antibody6c10 VIRAL PROTEIN 12/18/24 Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Olmedillas, E., Diaz, R., Hastie, K., Ollmann-Saphire, E. 2.93 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 8v5v c e 0 F protein NA variable domain of the heavy chain from the human antibody6c10 VIRAL PROTEIN 12/18/24 Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Olmedillas, E., Diaz, R., Hastie, K., Ollmann-Saphire, E. 2.93 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 8v8f B b 0 E peptide NA utag PEPTIDE BINDING PROTEIN 12/11/24 The co-crystal structure of anti-HIV scFv and Utag. Mus musculus; SYNTHETIC CONSTRUCT mus musculus human immunodeficiency virus 1 Chen, S.H., Snow, C.D. 2.27 X-RAY DIFFRACTION 0.280 0.222 True True unknown unknown unknown None None None None None 8v8f A a 0 H peptide NA utag PEPTIDE BINDING PROTEIN 12/11/24 The co-crystal structure of anti-HIV scFv and Utag. Mus musculus; SYNTHETIC CONSTRUCT mus musculus human immunodeficiency virus 1 Chen, S.H., Snow, C.D. 2.27 X-RAY DIFFRACTION 0.280 0.222 True True unknown unknown unknown None None None None None 8v8f C c 0 F peptide NA utag PEPTIDE BINDING PROTEIN 12/11/24 The co-crystal structure of anti-HIV scFv and Utag. Mus musculus; SYNTHETIC CONSTRUCT mus musculus human immunodeficiency virus 1 Chen, S.H., Snow, C.D. 2.27 X-RAY DIFFRACTION 0.280 0.222 True True unknown unknown unknown None None None None None 8v8f D d 0 G peptide NA utag PEPTIDE BINDING PROTEIN 12/11/24 The co-crystal structure of anti-HIV scFv and Utag. Mus musculus; SYNTHETIC CONSTRUCT mus musculus human immunodeficiency virus 1 Chen, S.H., Snow, C.D. 2.27 X-RAY DIFFRACTION 0.280 0.222 True True unknown unknown unknown None None None None None 8v91 J I 0 C | B protein | protein NA | NA aquaporin-4 | aquaporin-4 TRANSPORT PROTEIN/IMMUNE SYSTEM 12/11/24 Structure of human AQP4 with a pathogenic autoantibody- rAB 58 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Gupta, M., Khandelwal, N.K., Stroud, R.M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8v93 A C 0 D protein NA type 1 fimbrin d-mannose specific adhesin fimh, donorstrand complemented with fimg peptide 'triple mutant' CELL ADHESION/IMMUNE SYSTEM 12/18/24 Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 329-2 and 454-3 Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Lees, J.A., Han, S. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 8v93 B L 0 D protein NA type 1 fimbrin d-mannose specific adhesin fimh, donorstrand complemented with fimg peptide 'triple mutant' CELL ADHESION/IMMUNE SYSTEM 12/18/24 Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 329-2 and 454-3 Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Lees, J.A., Han, S. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 8vc7 J D 0 C protein NA butyrophilin subfamily 2 member a1 SIGNALING PROTEIN 12/18/24 Crystal Structure of Human BTN2A1 ectodomain in complex with Antagonist 2A1.9 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ramesh, A., Roy, S., Adams, E. 2.76 X-RAY DIFFRACTION 0.261 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8vc7 B A 0 E protein NA butyrophilin subfamily 2 member a1 SIGNALING PROTEIN 12/18/24 Crystal Structure of Human BTN2A1 ectodomain in complex with Antagonist 2A1.9 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ramesh, A., Roy, S., Adams, E. 2.76 X-RAY DIFFRACTION 0.261 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8vti D C 0 A protein NA isoform 4 of adhesion g protein-coupled receptor l3 SIGNALING PROTEIN 12/11/24 Latrophilin-3 (ADGRL3) HormR and GAIN domains in the context of the holoreceptor Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Kordon, S.P., Bandekar, S.J., Arac, D. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xef B C 0 A protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 Cocktail GC2050-GC2225 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 4.41 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 8xef D E 0 A protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 12/11/24 Cocktail GC2050-GC2225 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 4.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8xrq B C 0 A protein NA spike protein s1 PROTEIN BINDING 12/18/24 SARS-CoV-2 BA.1 spike RBD in complex bound with VacBB-639 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, C.C., Ju, B., Zhang, Z. 4.19 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8y4w B NA 0 A protein NA n-acetylneuraminate transporter small subunit MEMBRANE PROTEIN/IMMUNE SYSTEM 12/11/24 Sialic acid bound form of Tripartite ATP-independent Periplasmic (TRAP) transporter from Fusobacterium nucleatum. Fusobacterium nucleatum; Vicugna pacos vicugna pacos fusobacterium nucleatum Goyal, P., Ramaswamy, S., Vinothkumar, K.R. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8y4x B NA 0 A protein NA n-acetylneuraminate transporter small subunit MEMBRANE PROTEIN/IMMUNE SYSTEM 12/11/24 Apo form of Tripartite ATP-independent Periplasmic (TRAP) transporter from Fusobacterium nucleatum. Fusobacterium nucleatum; Vicugna pacos vicugna pacos fusobacterium nucleatum Goyal, P., Ramaswamy, S., Vinothkumar, K.R. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8y57 C D 0 NA NA NA NA IMMUNE SYSTEM 12/11/24 Anti MDMA antibody 1bB11 complex synthetic construct synthetic construct synthetic construct Cheon, G., Lee, Y., Lee, S. 3.2 X-RAY DIFFRACTION 0.301 0.243 False True IGHV3 IGLV1 Lambda None None None None None 8y57 A B 0 B Hapten B41 (2S)-1-(1,3-BENZODIOXOL-5-YL)-N-METHYLPROPAN-2-AMINE IMMUNE SYSTEM 12/11/24 Anti MDMA antibody 1bB11 complex synthetic construct synthetic construct synthetic construct synthetic construct Cheon, G., Lee, Y., Lee, S. 3.2 X-RAY DIFFRACTION 0.301 0.243 False True IGHV3 IGLV1 Lambda None None None None None 8yvj A NA 0 B protein NA toxin a TOXIN/IMMUNE SYSTEM 12/18/24 Crystal structure of the C. difficile toxin A CROPs domain fragment 2592-2710 bound to H5.2 nanobody Camelus dromedarius; Clostridioides difficile 342 camelus dromedarius clostridioides difficile 342 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Belyi, Y.F., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 1.65 X-RAY DIFFRACTION 0.198 0.149 False True IGHV1 NA NA None None None None None 8yvo A NA 0 C protein NA toxin a TOXIN/IMMUNE SYSTEM 12/18/24 Crystal structure of the C. difficile toxin A CROPs domain fragment 2639-2707 bound to C4.2 nanobody Camelus dromedarius; Clostridioides difficile camelus dromedarius clostridioides difficile Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Belyi, Y.F., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 2.1 X-RAY DIFFRACTION 0.238 0.210 False True IGHV1 NA NA None None None None None 8yvo B NA 0 D protein NA toxin a TOXIN/IMMUNE SYSTEM 12/18/24 Crystal structure of the C. difficile toxin A CROPs domain fragment 2639-2707 bound to C4.2 nanobody Camelus dromedarius; Clostridioides difficile camelus dromedarius clostridioides difficile Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Belyi, Y.F., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 2.1 X-RAY DIFFRACTION 0.238 0.210 False True IGHV1 NA NA None None None None None 8zpu A a 0 C peptide NA phe-pro-gln-phe-sep-tyr-ser IMMUNE SYSTEM 12/11/24 Crystal structure of the anti-phosphorylated peptide C7 scFv antibody with peptide bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Kawade, R., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.345 0.304 True True unknown unknown unknown None None None None None 8zpu B b 0 D peptide NA phe-pro-gln-phe-sep-tyr-ser IMMUNE SYSTEM 12/11/24 Crystal structure of the anti-phosphorylated peptide C7 scFv antibody with peptide bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Kawade, R., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.345 0.304 True True unknown unknown unknown None None None None None 8zxw H L 0 C peptide NA rac-gamma serine/threonine-protein kinase IMMUNE SYSTEM 12/11/24 Crystal structure of the anti-phosphorylated peptide C7 Fab antibody with peptide bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Kasahara, K., Tsumoto, K. 1.33 X-RAY DIFFRACTION 0.165 0.137 False True IGHV1 IGKV1 Kappa None None None None None 8zxw A B 0 D peptide NA rac-gamma serine/threonine-protein kinase IMMUNE SYSTEM 12/11/24 Crystal structure of the anti-phosphorylated peptide C7 Fab antibody with peptide bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Kasahara, K., Tsumoto, K. 1.33 X-RAY DIFFRACTION 0.165 0.137 False True IGHV1 IGKV1 Kappa None None None None None 9ast E e 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/11/24 Cryo-EM structure of XCR1 signaling complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Zhang, X., Zhang, C. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9b3k H L 0 Z protein NA nora-bril(3a) fusion TRANSPORT PROTEIN/IMMUNE SYSTEM 12/11/24 NorA in complex with Fab36 (NorA-BRIL fusion) Homo sapiens; Staphylococcus aureus homo sapiens homo sapiens staphylococcus aureus Xie, P., Li, Y., Kuang, H., Wang, D.N., Traaseth, N.J. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9b8j E F 0 A protein NA gp38 VIRAL PROTEIN 12/11/24 GP38-GnH-DS-Gc in the pre-fusion conformation Crimean-Congo hemorrhagic fever virus strain IbAr10200; Homo sapiens homo sapiens homo sapiens crimean-congo hemorrhagic fever virus strainibar10200 McFadden, E., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9b8j H L 0 D protein NA glycoprotein c VIRAL PROTEIN 12/11/24 GP38-GnH-DS-Gc in the pre-fusion conformation Crimean-Congo hemorrhagic fever virus strain IbAr10200; Homo sapiens homo sapiens homo sapiens crimean-congo hemorrhagic fever virus strainibar10200 McFadden, E., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9bsu E NA 0 A protein NA envelope glycoprotein VIRAL PROTEIN 12/18/24 EBOV GP/Nanosota-EB1 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Liu, B., Li, F. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9bsu D NA 0 C protein NA envelope glycoprotein VIRAL PROTEIN 12/18/24 EBOV GP/Nanosota-EB1 Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Liu, B., Li, F. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9bsv D NA 0 A protein NA envelope glycoprotein VIRAL PROTEIN 12/18/24 EBOV GP/Nanosota-EB2 complex Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Liu, B., Li, F. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9bsv E NA 0 C protein NA envelope glycoprotein VIRAL PROTEIN 12/18/24 EBOV GP/Nanosota-EB2 complex Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Liu, B., Li, F. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9bsv F NA 0 B protein NA envelope glycoprotein VIRAL PROTEIN 12/18/24 EBOV GP/Nanosota-EB2 complex Ebola virus; Vicugna pacos vicugna pacos ebola virus Bu, F., Ye, G., Liu, B., Li, F. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ekf D I 0 B protein NA hemagglutinin VIRAL PROTEIN 12/18/24 CryoEM structure of H5N1 A/Texas/37/2024 HA bound to Fab 65C6 and an auto glycan occupying the receptor-binding site Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Morano, N.C., Shapiro, L., Kwong, P.D. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9ekf G K 0 C protein NA hemagglutinin VIRAL PROTEIN 12/18/24 CryoEM structure of H5N1 A/Texas/37/2024 HA bound to Fab 65C6 and an auto glycan occupying the receptor-binding site Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Morano, N.C., Shapiro, L., Kwong, P.D. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9ekf H L 0 A protein NA hemagglutinin VIRAL PROTEIN 12/18/24 CryoEM structure of H5N1 A/Texas/37/2024 HA bound to Fab 65C6 and an auto glycan occupying the receptor-binding site Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Morano, N.C., Shapiro, L., Kwong, P.D. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 9ert B NA 0 A protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nano body 5E Mus musculus; Vicugna pacos vicugna pacos mus musculus Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 2.75 X-RAY DIFFRACTION 0.323 0.289 False True IGHV1 NA NA None None None None None 9erw E NA 0 B protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nanobody 8C Mus musculus; Vicugna pacos vicugna pacos mus musculus Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 1.73 X-RAY DIFFRACTION 0.215 0.191 False True IGHV1 NA NA None None None None None 9etj C NA 0 A protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nanobody 10E Mus musculus; Vicugna pacos vicugna pacos mus musculus Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 2.55 X-RAY DIFFRACTION 0.304 0.252 False True IGHV1 NA NA None None None None None 9etj D NA 0 B protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nanobody 10E Mus musculus; Vicugna pacos vicugna pacos mus musculus Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 2.55 X-RAY DIFFRACTION 0.304 0.252 False True IGHV1 NA NA None None None None None 9etj F NA 0 E protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nanobody 10E Mus musculus; Vicugna pacos vicugna pacos mus musculus Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 2.55 X-RAY DIFFRACTION 0.304 0.252 False True IGHV1 NA NA None None None None None 9etj H NA 0 G protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nanobody 10E Mus musculus; Vicugna pacos vicugna pacos mus musculus Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 2.55 X-RAY DIFFRACTION 0.304 0.252 False True IGHV1 NA NA None None None None None 9etl D NA 0 A protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nanobody 8D Mus musculus; Vicugna pacos vicugna pacos mus musculus Schroder, M., Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 1.5 X-RAY DIFFRACTION 0.229 0.179 False True IGHV3 NA NA None None None None None 9etl C NA 0 B protein NA 2',3'-cyclic-nucleotide 3'-phosphodiesterase PROTEIN BINDING 12/11/24 Mouse CNPase catalytic domain with nanobody 8D Mus musculus; Vicugna pacos vicugna pacos mus musculus Schroder, M., Markusson, S., Raasakka, A., Opazo, F., Kursula, P. 1.5 X-RAY DIFFRACTION 0.229 0.179 False True IGHV3 NA NA None None None None None 9jqt B C 0 A protein NA cytokine receptor common subunit gamma MEMBRANE PROTEIN 12/18/24 Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4 Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Lu, Q.J., Yin, H.Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9jqt D NA 0 NA NA NA NA MEMBRANE PROTEIN 12/18/24 Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4 Homo sapiens; Lama glama lama glama Lu, Q.J., Yin, H.Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jkh h l 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of sNS1 complexed with Fab 4B8 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Pan, Q. 2.64 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 8jkh H L 0 A protein NA ns1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of sNS1 complexed with Fab 4B8 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Pan, Q. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jkh m n 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of sNS1 complexed with Fab 4B8 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Pan, Q. 2.64 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 8jkh M N 0 B protein NA ns1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of sNS1 complexed with Fab 4B8 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Pan, Q. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jqs h l 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of sNS1 complexed with Fab 14G5 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Pan, Q. 2.63 ELECTRON MICROSCOPY NA NA False False IGHV5 IGLV3 Lambda None None None None None 8jqs H L 0 A protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of sNS1 complexed with Fab 14G5 Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Chen, Q., Pan, Q. 2.63 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV3 Lambda None None None None None 8tn4 H L 0 NA NA NA NA IMMUNE SYSTEM 12/04/24 The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, used to study poly-N-acetyl-glucosamine broadly expressed in biofilm-forming pathogenclonal antibody Homo sapiens homo sapiens homo sapiens Li, M., Wlodawer, A., Temme, S., Gildersleeve, J. 1.4 X-RAY DIFFRACTION 0.170 0.135 False True IGHV3 IGKV3 Kappa None None None None None 8tn5 H L 0 L carbohydrate GCS D-GLUCOSAMINE IMMUNE SYSTEM 12/04/24 The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a GlcNH2 Homo sapiens homo sapiens homo sapiens homo sapiens Li, M., Wlodawer, A., Temme, S., Gildersleeve, J. 1.76 X-RAY DIFFRACTION 0.206 0.164 False True IGHV3 IGKV3 Kappa None None None None None 8tn7 H L 0 A carbohydrate GCS D-GLUCOSAMINE IMMUNE SYSTEM 12/04/24 The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a disaccharide Homo sapiens homo sapiens homo sapiens Li, M., Wlodawer, A., Temme, S., Gildersleeve, J. 1.56 X-RAY DIFFRACTION 0.199 0.170 False True IGHV3 IGKV3 Kappa None None None None None 8tyw N NA 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/04/24 cryo-EM structure of GPR6-Gs-Nb35 complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Barekatain, M., Johansson, L.C., Lam, J.H., Sadybekov, A.V., Han, G.W., Popov, P., Russo, J., Bliesath, J., Brice, N., Beresford, M., Carlson, L., Saikatendu, K.S., Sun, H., Murphy, S., Monenschein, H., Schiffer, H.H., Lutomski, C., Robinson, C.V., Liu, J., Hua, T., Katritch, V., Cherezov, V. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xfp E NA 0 A protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 12/04/24 the pentamerA complex of LGR4-RSPO2-ZNRF3(delta RING) Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Geng, Y., Wang, L. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xfs F NA 0 A protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 12/04/24 LGR4-RSPO2-ZNRF3 RING domain (1:2:2) Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Lu, W., Yong, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xft E NA 0 A protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 12/04/24 LGR4-RSPO2-ZNRF3(1:1:1) Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Lu, W., Yong, G. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8y2k B A 0 NA NA NA NA IMMUNE SYSTEM 12/04/24 The crystal structure of QX006N-Fab Homo sapiens homo sapiens homo sapiens Li, W., Feng, W. 2.87 X-RAY DIFFRACTION 0.268 0.215 False True IGHV3 IGKV1 Kappa None None None None None 8y2k D C 0 NA NA NA NA IMMUNE SYSTEM 12/04/24 The crystal structure of QX006N-Fab Homo sapiens homo sapiens homo sapiens Li, W., Feng, W. 2.87 X-RAY DIFFRACTION 0.268 0.215 False True IGHV3 IGKV1 Kappa None None None None None 8y31 B A 0 E protein NA interferon alpha/beta receptor 1 IMMUNE SYSTEM 12/04/24 The crystal structure of the QX006N-Fab/IFNAR1-SD123 complex Homo sapiens homo sapiens homo sapiens homo sapiens Li, W., Feng, W. 2.68 X-RAY DIFFRACTION 0.239 0.194 False True IGHV3 IGKV1 Kappa None None None None None 8y31 D C 0 F protein NA interferon alpha/beta receptor 1 IMMUNE SYSTEM 12/04/24 The crystal structure of the QX006N-Fab/IFNAR1-SD123 complex Homo sapiens homo sapiens homo sapiens homo sapiens Li, W., Feng, W. 2.68 X-RAY DIFFRACTION 0.239 0.194 False True IGHV3 IGKV1 Kappa None None None None None 8y69 E NA 0 A protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 12/04/24 LGR4-RSPO2-ZNRF3 (2:2:2) Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8y69 I NA 0 D protein NA leucine-rich repeat-containing g-protein coupled receptor4 MEMBRANE PROTEIN 12/04/24 LGR4-RSPO2-ZNRF3 (2:2:2) Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens Wang, L., Geng, Y. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9b2w B C 0 A protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/Immune System 12/04/24 PIV3 HN with Fab 13 Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Durie, I.A., Mousa, J.J. 2.51 X-RAY DIFFRACTION 0.264 0.219 False True IGHV3 IGKV2 Kappa None None None None None 9b2w E F 0 D protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/Immune System 12/04/24 PIV3 HN with Fab 13 Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Durie, I.A., Mousa, J.J. 2.51 X-RAY DIFFRACTION 0.264 0.219 False True IGHV3 IGKV2 Kappa None None None None None 9b82 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.38 X-RAY DIFFRACTION 0.295 0.242 False True IGHV3 IGKV2 Kappa None None None None None 9b82 I G 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.38 X-RAY DIFFRACTION 0.295 0.242 False True IGHV3 IGKV2 Kappa None None None None None 9b82 K J 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.38 X-RAY DIFFRACTION 0.295 0.242 False True IGHV3 IGKV2 Kappa None None None None None 9b82 N M 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.38 X-RAY DIFFRACTION 0.295 0.242 False True IGHV3 IGKV2 Kappa None None None None None 9b82 P O 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.38 X-RAY DIFFRACTION 0.295 0.242 False True IGHV3 IGKV2 Kappa None None None None None 9b82 R Q 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.38 X-RAY DIFFRACTION 0.295 0.242 False True IGHV3 IGKV2 Kappa None None None None None 9dh2 A D 0 R protein NA nkg2-d type ii integral membrane protein IMMUNE SYSTEM 12/04/24 Structure of Fab in complex with NKG2D extracellular domain Homo sapiens homo sapiens homo sapiens homo sapiens Fallon, D., Huang, C.S. 2.98 X-RAY DIFFRACTION 0.243 0.197 False True IGHV1 IGKV1 Kappa None None None None None 9dh2 G H 0 T protein NA nkg2-d type ii integral membrane protein IMMUNE SYSTEM 12/04/24 Structure of Fab in complex with NKG2D extracellular domain Homo sapiens homo sapiens homo sapiens homo sapiens Fallon, D., Huang, C.S. 2.98 X-RAY DIFFRACTION 0.243 0.197 False True IGHV1 IGKV1 Kappa None None None None None 9dh2 K L 0 M protein NA nkg2-d type ii integral membrane protein IMMUNE SYSTEM 12/04/24 Structure of Fab in complex with NKG2D extracellular domain Homo sapiens homo sapiens homo sapiens homo sapiens Fallon, D., Huang, C.S. 2.98 X-RAY DIFFRACTION 0.243 0.197 False True IGHV1 IGKV1 Kappa None None None None None 9dh2 P Q 0 S protein NA nkg2-d type ii integral membrane protein IMMUNE SYSTEM 12/04/24 Structure of Fab in complex with NKG2D extracellular domain Homo sapiens homo sapiens homo sapiens homo sapiens Fallon, D., Huang, C.S. 2.98 X-RAY DIFFRACTION 0.243 0.197 False True IGHV1 IGKV1 Kappa None None None None None 9dwe H L 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Cryo-EM structure of hemagglutinin H5 A/Texas/37/2024 in complex with LSTa and antibody CR9114 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Fernandez-Quintero, M.L., Han, J., Rodriguez, A.J., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9dwe I M 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Cryo-EM structure of hemagglutinin H5 A/Texas/37/2024 in complex with LSTa and antibody CR9114 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Fernandez-Quintero, M.L., Han, J., Rodriguez, A.J., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9dwe J N 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 Cryo-EM structure of hemagglutinin H5 A/Texas/37/2024 in complex with LSTa and antibody CR9114 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Fernandez-Quintero, M.L., Han, J., Rodriguez, A.J., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 9dzq G I 0 A protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of the human antibodies PIV3HN-05 and PIV3HN-13 in complex with the parainfluenza virus hemagglutinin-neuraminidase protein Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Mousa, J.J., Miller, R.J. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9dzq H J 0 B protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of the human antibodies PIV3HN-05 and PIV3HN-13 in complex with the parainfluenza virus hemagglutinin-neuraminidase protein Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Mousa, J.J., Miller, R.J. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9dzq C NA 0 A protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of the human antibodies PIV3HN-05 and PIV3HN-13 in complex with the parainfluenza virus hemagglutinin-neuraminidase protein Homo sapiens; Human respirovirus 3 homo sapiens human respirovirus 3 Mousa, J.J., Miller, R.J. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9dzq NA E 0 A protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of the human antibodies PIV3HN-05 and PIV3HN-13 in complex with the parainfluenza virus hemagglutinin-neuraminidase protein Homo sapiens; Human respirovirus 3 homo sapiens human respirovirus 3 Mousa, J.J., Miller, R.J. 3.57 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9dzq D NA 0 B protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of the human antibodies PIV3HN-05 and PIV3HN-13 in complex with the parainfluenza virus hemagglutinin-neuraminidase protein Homo sapiens; Human respirovirus 3 homo sapiens human respirovirus 3 Mousa, J.J., Miller, R.J. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9dzq NA F 0 B protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 12/04/24 CryoEM structure of the human antibodies PIV3HN-05 and PIV3HN-13 in complex with the parainfluenza virus hemagglutinin-neuraminidase protein Homo sapiens; Human respirovirus 3 homo sapiens human respirovirus 3 Mousa, J.J., Miller, R.J. 3.57 ELECTRON MICROSCOPY NA NA False True NA IGLV1 Lambda None None None None None 9eg6 B NA 0 A peptide NA caveolae-associated protein 1 PROTEIN TRANSPORT 12/04/24 Crystal structure of the human Cavin1 HR1 HT/II mutant domain bound to nanobody B7 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Collins, B.M., Gao, Y. 3.2 X-RAY DIFFRACTION 0.287 0.258 False True IGHV1 NA NA None None None None None 9eg6 D NA 0 C peptide NA caveolae-associated protein 1 PROTEIN TRANSPORT 12/04/24 Crystal structure of the human Cavin1 HR1 HT/II mutant domain bound to nanobody B7 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Collins, B.M., Gao, Y. 3.2 X-RAY DIFFRACTION 0.287 0.258 False True IGHV1 NA NA None None None None None 9eg6 F NA 0 E peptide NA caveolae-associated protein 1 PROTEIN TRANSPORT 12/04/24 Crystal structure of the human Cavin1 HR1 HT/II mutant domain bound to nanobody B7 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Collins, B.M., Gao, Y. 3.2 X-RAY DIFFRACTION 0.287 0.258 False True IGHV1 NA NA None None None None None 9bu6 A B 0 D | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 11/27/24 Vaccine elicited Fab C968.180 with influenza H10 JD13 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bu6 E F 0 H | G protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 11/27/24 Vaccine elicited Fab C968.180 with influenza H10 JD13 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bu6 I J 0 L | K protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 11/27/24 Vaccine elicited Fab C968.180 with influenza H10 JD13 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9bu8 C D 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 11/27/24 Vaccine elicited Fab c115.131 with influenza H10 JD13 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9bu8 F H 0 L | J protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 11/27/24 Vaccine elicited Fab c115.131 with influenza H10 JD13 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9bu8 I K 0 G | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 11/27/24 Vaccine elicited Fab c115.131 with influenza H10 JD13 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8rj7 B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 11/27/24 The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29 Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Fernandez, L.A., Silva, K. 2.1 X-RAY DIFFRACTION 0.222 0.181 False True IGHV1 NA NA None None None None None 8rj7 D NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 11/27/24 The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29 Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Fernandez, L.A., Silva, K. 2.1 X-RAY DIFFRACTION 0.222 0.181 False True IGHV1 NA NA None None None None None 8rj7 F NA 0 E protein NA spike protein s1 ANTIVIRAL PROTEIN 11/27/24 The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29 Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Fernandez, L.A., Silva, K. 2.1 X-RAY DIFFRACTION 0.222 0.181 False True IGHV1 NA NA None None None None None 8rj7 H NA 0 G protein NA spike protein s1 ANTIVIRAL PROTEIN 11/27/24 The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29 Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Fernandez, L.A., Silva, K. 2.1 X-RAY DIFFRACTION 0.222 0.181 False True IGHV1 NA NA None None None None None 8rj7 J NA 0 I protein NA spike protein s1 ANTIVIRAL PROTEIN 11/27/24 The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29 Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Fernandez, L.A., Silva, K. 2.1 X-RAY DIFFRACTION 0.222 0.181 False True IGHV1 NA NA None None None None None 8rql S s 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 11/27/24 GPCR - G-protein complex Homo sapiens; Mus musculoides mus musculoides homo sapiens | homo sapiens | homo sapiens Matzov, D., Peri, L., Niv, M., Shalev Benami, M. 3.03 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8uzc H L 0 A protein NA hemagglutinin IMMUNE SYSTEM 11/27/24 Structure of UT14 Fab in complex with the head domain of H3 (A/Singapore/INFIMH-16-0019/2016) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Park, J., Georgiou, G. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8zd5 H I 0 G protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the holo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 2.89 X-RAY DIFFRACTION 0.249 0.201 False True IGHV14 IGKV14 Kappa None None None None None 8zd5 E F 0 D protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the holo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 2.89 X-RAY DIFFRACTION 0.249 0.201 False True IGHV14 IGKV14 Kappa None None None None None 8zd5 B C 0 A protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the holo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 2.89 X-RAY DIFFRACTION 0.249 0.201 False True IGHV14 IGKV14 Kappa None None None None None 8zd5 K L 0 J protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the holo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 2.89 X-RAY DIFFRACTION 0.249 0.201 False True IGHV14 IGKV14 Kappa None None None None None 8zd6 B C 0 A protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the apo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 3.29 X-RAY DIFFRACTION 0.326 0.277 False True IGHV14 IGKV14 Kappa None None None None None 8zd6 E F 0 D protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the apo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 3.29 X-RAY DIFFRACTION 0.326 0.277 False True IGHV14 IGKV14 Kappa None None None None None 8zd6 H I 0 G protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the apo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 3.29 X-RAY DIFFRACTION 0.326 0.277 False True IGHV14 IGKV14 Kappa None None None None None 8zd6 K L 0 J protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 11/27/24 Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the apo form complexed with 22E1 Fv-clasp Canis lupus familiaris; Mus musculus mus musculus mus musculus canis lupus familiaris Shino, Y., Furukawa, Y., Muraki, N. 3.29 X-RAY DIFFRACTION 0.326 0.277 False True IGHV14 IGKV14 Kappa None None None None None 9f6o B NA 0 A protein NA natural resistance-associated macrophage protein 2 TRANSPORT PROTEIN 11/27/24 Human divalent metal transporter 1 (DMT1/SLC11A2) in complex with sybody 1, in an occluded state Homo sapiens; synthetic construct synthetic construct homo sapiens Liziczai, M., Dutzler, R. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ivg N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/27/24 Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex Homo sapiens homo sapiens homo sapiens | homo sapiens Li, J., Li, G., Mai, Y., Liu, X., Yang, D., Zhou, Q., Wang, M.-W. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zre H L 0 C | D protein | protein NA | NA capsid protein | capsid protein VIRUS LIKE PARTICLE 11/13/24 HBcAg-D4 Fab complex hepatitis B virus genotype C; Homo sapiens homo sapiens homo sapiens hepatitis b virus genotype c | hepatitis b virus genotype c Liu, C., Yan, H., Ju, B. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8zre h l 0 A | B protein | protein NA | NA capsid protein | capsid protein VIRUS LIKE PARTICLE 11/13/24 HBcAg-D4 Fab complex hepatitis B virus genotype C; Homo sapiens homo sapiens homo sapiens hepatitis b virus genotype c | hepatitis b virus genotype c Liu, C., Yan, H., Ju, B. 3.44 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV2 Kappa None None None None None 8zrh h l 0 A | B protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 11/13/24 HBcAg-D4 Fab complex hepatitis B virus genotype C; Homo sapiens homo sapiens homo sapiens hepatitis b virus genotype c | hepatitis b virus genotype c Zhang, Z., Ju, B., Liu, C., Yan, H. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV2 Kappa None None None None None 8zrh H L 0 C | D protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 11/13/24 HBcAg-D4 Fab complex hepatitis B virus genotype C; Homo sapiens homo sapiens homo sapiens hepatitis b virus genotype c | hepatitis b virus genotype c Zhang, Z., Ju, B., Liu, C., Yan, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9bt8 H L 0 B | V protein | peptide NA | NA beta-arrestin-1 | vasopressin v2 receptor SIGNALING PROTEIN 11/13/24 Structure of Src in complex with beta-arrestin 1 revealing SH3 binding sites Bacteriophage sp.; Gallus gallus; Lama glama; Rattus norvegicus; SYNTHETIC CONSTRUCT bacteriophage sp. bacteriophage sp. rattus norvegicus | homo sapiens Pakharukova, N., Bansia, H., Bassford, D.K., des Georges, A., Lefkowitz, R.J. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9bt8 A NA 0 B protein NA beta-arrestin-1 SIGNALING PROTEIN 11/13/24 Structure of Src in complex with beta-arrestin 1 revealing SH3 binding sites Bacteriophage sp.; Gallus gallus; Lama glama; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama rattus norvegicus Pakharukova, N., Bansia, H., Bassford, D.K., des Georges, A., Lefkowitz, R.J. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9cx3 H L 0 B protein NA beta-arrestin-1 SIGNALING PROTEIN 11/13/24 Structure of SH3 domain of Src in complex with beta-arrestin 1 Gallus gallus; Lama glama; Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus Pakharukova, N., Bansia, H., des Georges, A., Lefkowitz, R.J. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cx3 A NA 0 B | V protein | peptide NA | NA beta-arrestin-1 | vasopressin v2 receptor SIGNALING PROTEIN 11/13/24 Structure of SH3 domain of Src in complex with beta-arrestin 1 Gallus gallus; Lama glama; Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama rattus norvegicus | homo sapiens Pakharukova, N., Bansia, H., des Georges, A., Lefkowitz, R.J. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jei S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/20/24 Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Fang, Y., Pan, X. 2.73 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8p12 H L 0 B | G protein | peptide NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(t) subunit gamma-t1 SIGNALING PROTEIN 11/20/24 Cryo-EM structure of Rhodopsin-Gi bound to antibody fragment Fab13 Bos taurus; Homo sapiens; Mus musculus mus musculus mus musculus bos taurus | bos taurus Pamula, F., Tejero, O., Muehle, J., Thoma, R., Schertler, G.F.X., Marino, J., Tsai, C.-J. 3.21 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV1 Kappa None None None None None 8rw9 A NA 0 NA NA NA NA STRUCTURAL PROTEIN 11/20/24 Domains 1 and 2 of Bacillus anthracis Sap S-layer in complex with Nb694 Bacillus anthracis; Lama glama lama glama Sogues, A., Remaut, H. 1.99 X-RAY DIFFRACTION 0.249 0.209 False True IGHV3 NA NA None None None None None 8rw9 B NA 0 NA NA NA NA STRUCTURAL PROTEIN 11/20/24 Domains 1 and 2 of Bacillus anthracis Sap S-layer in complex with Nb694 Bacillus anthracis; Lama glama lama glama Sogues, A., Remaut, H. 1.99 X-RAY DIFFRACTION 0.249 0.209 False True IGHV3 NA NA None None None None None 8rw9 C NA 0 NA NA NA NA STRUCTURAL PROTEIN 11/20/24 Domains 1 and 2 of Bacillus anthracis Sap S-layer in complex with Nb694 Bacillus anthracis; Lama glama lama glama Sogues, A., Remaut, H. 1.99 X-RAY DIFFRACTION 0.249 0.209 False True IGHV3 NA NA None None None None None 8rw9 D NA 0 E protein NA s-layer protein sap STRUCTURAL PROTEIN 11/20/24 Domains 1 and 2 of Bacillus anthracis Sap S-layer in complex with Nb694 Bacillus anthracis; Lama glama lama glama bacillus anthracis Sogues, A., Remaut, H. 1.99 X-RAY DIFFRACTION 0.249 0.209 False True IGHV3 NA NA None None None None None 8rwf C NA 0 B protein NA s-layer protein sap STRUCTURAL PROTEIN 11/20/24 Domains 1 and 2 of Bacillus anthracis Sap S-layer in complex with Nb692 Bacillus anthracis; Lama glama lama glama bacillus anthracis Sogues, A., Remaut, H. 3.11 X-RAY DIFFRACTION 0.285 0.221 False True IGHV1 NA NA None None None None None 8rwf E NA 0 D protein NA s-layer protein sap STRUCTURAL PROTEIN 11/20/24 Domains 1 and 2 of Bacillus anthracis Sap S-layer in complex with Nb692 Bacillus anthracis; Lama glama lama glama bacillus anthracis Sogues, A., Remaut, H. 3.11 X-RAY DIFFRACTION 0.285 0.221 False True IGHV1 NA NA None None None None None 8rwf G NA 0 A protein NA s-layer protein sap STRUCTURAL PROTEIN 11/20/24 Domains 1 and 2 of Bacillus anthracis Sap S-layer in complex with Nb692 Bacillus anthracis; Lama glama lama glama bacillus anthracis Sogues, A., Remaut, H. 3.11 X-RAY DIFFRACTION 0.285 0.221 False True IGHV1 NA NA None None None None None 8x3l S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/20/24 Cryo-EM structure of CB2-G protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Shen, S.Y., Yang, Z.Q., Shao, Z.H. 3.13 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9b9y N NA 0 R protein NA cannabinoid receptor 1,glycogen synthase SIGNALING PROTEIN/IMMUNE SYSTEM 11/20/24 Structural mechanism of CB1R binding to peripheral and biased inverse agonists Homo sapiens; Lama glama; Pyrococcus abyssi GE5 lama glama homo sapiens, pyrococcus abyssi ge5 Kumari, P., Szabolcs, D., Enos, M.D., Ramesh, K., Lim, D., Hassan, S.A., Kunos, G., Iyer, M.R., Rosenbaum, D.M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9bif H L 0 B protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9bif C D 0 A protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9bif G I 0 E protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9bif J K 0 F protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9bif O P 0 M protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9bif Q R 0 N protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9bif U V 0 S protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9bif W X 0 T protein NA outer surface protein c IMMUNE SYSTEM 11/20/24 Fab B11-OspCA complex Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.09 X-RAY DIFFRACTION 0.295 0.240 False True IGHV4 IGKV3 Kappa None None None None None 9c44 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/20/24 SARS-CoV-2 S + S2L20 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9c44 E D 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/20/24 SARS-CoV-2 S + S2L20 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9c44 F G 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/20/24 SARS-CoV-2 S + S2L20 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9c45 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 SARS-CoV-2 S + S2L20 (local refinement of NTD and S2L20 Fab variable region) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9co6 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/20/24 BA.5 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co6 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/20/24 BA.5 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co6 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/20/24 BA.5 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co7 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 Local refinement of BA.5 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co7 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 Local refinement of BA.5 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co8 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 JN.1 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co8 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 JN.1 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co8 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 JN.1 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co9 D NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 Local refinement of JN.1 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9co9 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/20/24 Local refinement of JN.1 spike/Nanosota-9 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9e6k H L 0 C protein NA disintegrin and metalloproteinase domain-containing protein17 ANTITUMOR PROTEIN/IMMUNE SYSTEM 11/20/24 Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells. Homo sapiens homo sapiens homo sapiens homo sapiens Saha, N., De La Cruz, M.J., Goldgur, Y., Nikolov, D.B. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9ivk H L 0 A protein NA hbc599 membrane protein binder MEMBRANE PROTEIN/IMMUNE SYSTEM 11/20/24 cryo-EM structure of a tmFAP artificial sequences; Homo sapiens homo sapiens homo sapiens artificial sequences Sun, K., Zhu, J.Y., Liang, M.F., Lu, P.L. 2.74 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8qz6 B NA 0 A protein NA isoform 2 of ceramide synthase 6 MEMBRANE PROTEIN 11/13/24 Structure of human ceramide synthase 6 (CerS6) bound to C16:0 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Pascoa, T.C., Pike, A.C.W., Chi, G., Stefanic, S., Quigley, A., Chalk, R., Mukhopadhyay, S.M.M., Venkaya, S., Dix, C., Moreira, T., Tessitore, A., Cole, V., Chu, A., Elkins, J.M., Pautsch, A., Schnapp, G., Carpenter, E.P., Sauer, D.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8qz6 D NA 0 C protein NA isoform 2 of ceramide synthase 6 MEMBRANE PROTEIN 11/13/24 Structure of human ceramide synthase 6 (CerS6) bound to C16:0 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Pascoa, T.C., Pike, A.C.W., Chi, G., Stefanic, S., Quigley, A., Chalk, R., Mukhopadhyay, S.M.M., Venkaya, S., Dix, C., Moreira, T., Tessitore, A., Cole, V., Chu, A., Elkins, J.M., Pautsch, A., Schnapp, G., Carpenter, E.P., Sauer, D.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8qz7 B NA 0 A protein NA isoform 2 of ceramide synthase 6 MEMBRANE PROTEIN 11/13/24 Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Pascoa, T.C., Pike, A.C.W., Chi, G., Stefanic, S., Quigley, A., Chalk, R., Mukhopadhyay, S.M.M., Venkaya, S., Dix, C., Moreira, T., Tessitore, A., Cole, V., Chu, A., Elkins, J.M., Pautsch, A., Schnapp, G., Carpenter, E.P., Sauer, D.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8qz7 D NA 0 C protein NA isoform 2 of ceramide synthase 6 MEMBRANE PROTEIN 11/13/24 Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Pascoa, T.C., Pike, A.C.W., Chi, G., Stefanic, S., Quigley, A., Chalk, R., Mukhopadhyay, S.M.M., Venkaya, S., Dix, C., Moreira, T., Tessitore, A., Cole, V., Chu, A., Elkins, J.M., Pautsch, A., Schnapp, G., Carpenter, E.P., Sauer, D.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8uwz C D 0 F protein NA isoform vegf121 of vascular endothelial growth factor a,long form SIGNALING PROTEIN 11/13/24 The structure of Raamsizumab in complex with VEGF121 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H., Blazer, L., Sicheri, F., Adams, J.J., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.298 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8uwz A B 0 E protein NA isoform vegf121 of vascular endothelial growth factor a,long form SIGNALING PROTEIN 11/13/24 The structure of Raamsizumab in complex with VEGF121 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H., Blazer, L., Sicheri, F., Adams, J.J., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.298 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8wwh E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 MCHR1-Gi complex,S1 state Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Gong, W., Ye, X., Liu, G. 2.84 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wwi E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 MCHR1-Gi complex,S3 state Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Gong, W., Ye, X., Liu, G. 3.43 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wwj E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 MCHR1-Gi complex,S2 state Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Ye, X., Gong, W., Liu, G. 3.03 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wwk E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 MCH-MCHR1-Gi complex, T1 state Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Gong, W., Ye, X., Liu, G. 2.61 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wwl E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 MCH-MCHR1-Gi complex, T2 state Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Gong, W., Ye, X., Liu, G. 2.78 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wwm E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 MCH-MCHR1-Gi complex, L2 state Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Gong, W., Ye, X., Liu, G. 2.81 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wwn E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 MCH-MCHR1-Gi complex,L1 state Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Gong, W., Ye, X., Liu, G. 2.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wyj Q R 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 The global map of Omicron Subvariants Spike with two antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, A.J., Yang, H.N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8wyj S T 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 The global map of Omicron Subvariants Spike with two antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, A.J., Yang, H.N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8wyj D F 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 The global map of Omicron Subvariants Spike with two antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, A.J., Yang, H.N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8wyj E G 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 The global map of Omicron Subvariants Spike with two antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, A.J., Yang, H.N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8wyj H J 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 The global map of Omicron Subvariants Spike with two antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, A.J., Yang, H.N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8wyj I K 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 The global map of Omicron Subvariants Spike with two antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, A.J., Yang, H.N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8wz3 D F 0 A protein NA rsv fusion glycoprotein VIRAL PROTEIN 11/13/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nAb 5B11 Human respiratory syncytial virus A2; Mus musculus mus musculus mus musculus human respiratory syncytial virus a2 Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8wz3 E H 0 B protein NA rsv fusion glycoprotein VIRAL PROTEIN 11/13/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nAb 5B11 Human respiratory syncytial virus A2; Mus musculus mus musculus mus musculus human respiratory syncytial virus a2 Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8wz3 G K 0 C protein NA rsv fusion glycoprotein VIRAL PROTEIN 11/13/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nAb 5B11 Human respiratory syncytial virus A2; Mus musculus mus musculus mus musculus human respiratory syncytial virus a2 Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8wz5 H L 0 A protein NA rsv fusion glycoprotein VIRAL PROTEIN 11/13/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 sc9-10 strain: B18537) in complex with humanized nAb 5B11 Human respiratory syncytial virus B; Mus musculus mus musculus mus musculus human respiratory syncytial virus b Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8wz5 D F 0 B protein NA rsv fusion glycoprotein VIRAL PROTEIN 11/13/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 sc9-10 strain: B18537) in complex with humanized nAb 5B11 Human respiratory syncytial virus B; Mus musculus mus musculus mus musculus human respiratory syncytial virus b Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8wz5 E G 0 C protein NA rsv fusion glycoprotein VIRAL PROTEIN 11/13/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 sc9-10 strain: B18537) in complex with humanized nAb 5B11 Human respiratory syncytial virus B; Mus musculus mus musculus mus musculus human respiratory syncytial virus b Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8wze H L 0 C protein NA rsv pre-fusion glycoprotein VIRAL PROTEIN 11/13/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 sc9-10 strain: B18537) in complex with humanized nAb 5B11 (localized refinement) Human respiratory syncytial virus B; Mus musculus mus musculus mus musculus human respiratory syncytial virus b Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8xcd H L 0 A protein NA solute carrier family 10 member a1 TRANSPORT PROTEIN/IMMUNE SYSTEM 11/13/24 Macaca fascicularis NTCP in complex with YN69083 Fab Macaca fascicularis; Mus musculus mus musculus mus musculus macaca fascicularis Park, J.H., Ishimoto, N., Park, S.Y. 3.49 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 8xyd E e 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/13/24 Structure of Platelet-activating factor receptor-G protein complex bound to platelet-activating factor Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Fan, W., Xu, Y., Zhuang, Y., Xu, H.E. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zrr h l 0 B | A protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 11/13/24 Dimer-AB and Fab-hl complex of HBcAg hepatitis B virus genotype C; Homo sapiens homo sapiens homo sapiens hepatitis b virus genotype c | hepatitis b virus genotype c Zhang, Z., Ju, B., Liu, C., Yan, H. 3.61 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV2 Kappa None None None None None 9axl H L 0 B protein NA integrin beta-3 BLOOD CLOTTING/IMMUNE SYSTEM 11/13/24 Structure of the semi-extended AlphaIIbBeta3 in complex with R21D10 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Wang, J.L., Walz, T., Coller, B., Wang, L., Li, J.H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 9b2c H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/13/24 Structure of the Porcine deltacoronavirus (PDCoV) receptor-binding domain bound to the PD33 antibody Fab fragment and the Kappa light chain nanobody Lama glama; Mus sp.; Porcine deltacoronavirus mus sp. mus sp. porcine deltacoronavirus Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 9b2c N NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 11/13/24 Structure of the Porcine deltacoronavirus (PDCoV) receptor-binding domain bound to the PD33 antibody Fab fragment and the Kappa light chain nanobody Lama glama; Mus sp.; Porcine deltacoronavirus lama glama Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9bdf B I 0 H protein NA hemagglutinin VIRAL PROTEIN 11/13/24 Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85666 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9bdf C D 0 A protein NA hemagglutinin VIRAL PROTEIN 11/13/24 Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85666 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9bdf E J 0 G protein NA hemagglutinin VIRAL PROTEIN 11/13/24 Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85666 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 9bdg D G 0 B protein NA hemagglutinin VIRAL PROTEIN 11/13/24 Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85647 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9bdg E H 0 C protein NA hemagglutinin VIRAL PROTEIN 11/13/24 Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85647 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9bdg F I 0 A protein NA hemagglutinin VIRAL PROTEIN 11/13/24 Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85647 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Ferreira Ramos, A.S., Bajic, G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9cx9 H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | vasopressin v2 receptor SIGNALING PROTEIN 11/13/24 Structure of SH3 domain of Src in complex with beta-arrestin 1 Gallus gallus; Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Pakharukova, N., Bansia, H., Lefkowitz, R.J., des Georges, A. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9dez H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 PDCoV S trimer bound by three copies of PD41 Fab Mus musculus; Porcine deltacoronavirus mus musculus mus musculus porcine deltacoronavirus Asarnow, D., Rexhepaj, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D., Center for Structural Genomics of Infectious Diseases (CSGID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9dez I M 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 PDCoV S trimer bound by three copies of PD41 Fab Mus musculus; Porcine deltacoronavirus mus musculus mus musculus porcine deltacoronavirus Asarnow, D., Rexhepaj, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D., Center for Structural Genomics of Infectious Diseases (CSGID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9dez J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 PDCoV S trimer bound by three copies of PD41 Fab Mus musculus; Porcine deltacoronavirus mus musculus mus musculus porcine deltacoronavirus Asarnow, D., Rexhepaj, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D., Center for Structural Genomics of Infectious Diseases (CSGID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9df0 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/13/24 PDCoV S RBD bound to PD41 Fab (local refinement) Mus musculus; Porcine deltacoronavirus mus musculus mus musculus porcine deltacoronavirus Asarnow, D., Rexhepaj, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9dx6 B C 0 A protein NA apical merozoite protein 1 CELL INVASION 11/13/24 Crystal structure of Plasmodium vivax (Palo Alto) PvAMA1 in complex with human Fab 826827 Homo sapiens; Plasmodium vivax homo sapiens homo sapiens plasmodium vivax Dietrich, M.H., Tham, W.H., Jung, N.C. 2.4 X-RAY DIFFRACTION 0.235 0.192 False True IGHV4 IGKV3 Kappa None None None None None 9eot B NA 0 A protein NA isoform 2 of ceramide synthase 6 MEMBRANE PROTEIN 11/13/24 Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02) Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Pascoa, T.C., Pike, A.C.W., Chi, G., Stefanic, S., Quigley, A., Chalk, R., Mukhopadhyay, S.M.M., Venkaya, S., Dix, C., Moreira, T., Tessitore, A., Cole, V., Chu, A., Elkins, J.M., Pautsch, A., Schnapp, G., Carpenter, E.P., Sauer, D.B. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9eot D NA 0 C protein NA isoform 2 of ceramide synthase 6 MEMBRANE PROTEIN 11/13/24 Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02) Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Pascoa, T.C., Pike, A.C.W., Chi, G., Stefanic, S., Quigley, A., Chalk, R., Mukhopadhyay, S.M.M., Venkaya, S., Dix, C., Moreira, T., Tessitore, A., Cole, V., Chu, A., Elkins, J.M., Pautsch, A., Schnapp, G., Carpenter, E.P., Sauer, D.B. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ulk D E 0 J | A protein | protein NA | NA fusion glycoprotein f0,fibritin | fusion glycoprotein f2 VIRAL PROTEIN/IMMUNE SYSTEM 11/06/24 Prefusion RSV F bound by neutralizing antibody 1G12 Homo sapiens; Human respiratory syncytial virus A2; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 | human respiratory syncytial virus a2 Harshbarger, W.D., Andreano, E., Malito, E. 4.28 X-RAY DIFFRACTION 0.279 0.244 False True IGHV1 IGKV2 Kappa None None None None None 8ulk H L 0 K | B protein | protein NA | NA fusion glycoprotein f0,fibritin | fusion glycoprotein f2 VIRAL PROTEIN/IMMUNE SYSTEM 11/06/24 Prefusion RSV F bound by neutralizing antibody 1G12 Homo sapiens; Human respiratory syncytial virus A2; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 | human respiratory syncytial virus a2 Harshbarger, W.D., Andreano, E., Malito, E. 4.28 X-RAY DIFFRACTION 0.279 0.244 False True IGHV1 IGKV2 Kappa None None None None None 8ulk F G 0 I | C protein | protein NA | NA fusion glycoprotein f0,fibritin | fusion glycoprotein f2 VIRAL PROTEIN/IMMUNE SYSTEM 11/06/24 Prefusion RSV F bound by neutralizing antibody 1G12 Homo sapiens; Human respiratory syncytial virus A2; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 | human respiratory syncytial virus a2 Harshbarger, W.D., Andreano, E., Malito, E. 4.28 X-RAY DIFFRACTION 0.279 0.244 False True IGHV1 IGKV2 Kappa None None None None None 8k4s D d 0 A | B protein | protein NA | NA gs-mini-gq chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/06/24 CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P Aequorea victoria; Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yang, J., Fan, J.P., Lei, X.G. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8pxo D C 0 B protein NA broad substrate specificity atp-binding cassettetransporter abcg2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with AZ99 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Yu, Q., Kowal, J., Tajkhorshid, E., Altmann, K.H., Locher, K.P. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV13 Kappa None None None None None 8pxo F E 0 A protein NA broad substrate specificity atp-binding cassettetransporter abcg2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with AZ99 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Yu, Q., Kowal, J., Tajkhorshid, E., Altmann, K.H., Locher, K.P. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV13 Kappa None None None None None 8py4 D C 0 B protein NA broad substrate specificity atp-binding cassettetransporter abcg2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with ko143 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Yu, Q., Kowal, J., Tajkhorshid, E., Altmann, K.H., Locher, K.P. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV13 Kappa None None None None None 8py4 F E 0 A protein NA broad substrate specificity atp-binding cassettetransporter abcg2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with ko143 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Yu, Q., Kowal, J., Tajkhorshid, E., Altmann, K.H., Locher, K.P. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV13 Kappa None None None None None 8q7b D C 0 B protein NA atp-binding cassette sub-family g member 2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with MZ29 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kowal, J., Yu, Q., Ni, D., Stahlberg, H., Tajkhorshid, E., Altmann, K.H., Locher, K.P., Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Zechner, M. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8q7b F E 0 A protein NA atp-binding cassette sub-family g member 2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with MZ29 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kowal, J., Yu, Q., Ni, D., Stahlberg, H., Tajkhorshid, E., Altmann, K.H., Locher, K.P., Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Zechner, M. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8qcm D C 0 B protein NA broad substrate specificity atp-binding cassettetransporter abcg2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with MZ82 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Yu, Q., Kowal, J., Ni, D., Stahlberg, H., Tajkhorshid, E., Altmann, K.H., Locher, K.P. 2.39 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV13 Kappa None None None None None 8qcm F E 0 A protein NA broad substrate specificity atp-binding cassettetransporter abcg2 TRANSPORT PROTEIN 11/06/24 ABCG2 in complex with MZ82 and 5D3 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Yu, Q., Kowal, J., Ni, D., Stahlberg, H., Tajkhorshid, E., Altmann, K.H., Locher, K.P. 2.39 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV13 Kappa None None None None None 8r3w A a 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of a homospecific CR57 diabody Homo sapiens homo sapiens Kedari, A., Rissanen, I. 2.38 X-RAY DIFFRACTION 0.227 0.191 True True unknown unknown unknown None None None None None 8r3w R r 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of a homospecific CR57 diabody Homo sapiens homo sapiens Kedari, A., Rissanen, I. 2.38 X-RAY DIFFRACTION 0.227 0.191 True True unknown unknown unknown None None None None None 8r40 R r 0 G protein NA glycoprotein VIRAL PROTEIN 11/06/24 Crystal structure of diabody CR57 in complex with rabies virus protein G domain III Homo sapiens; Rabies virus CVS-11 homo sapiens rabies virus cvs-11 Kedari, A., Rissanen, I. 2.7 X-RAY DIFFRACTION 0.259 0.217 True True unknown unknown unknown None None None None None 8r40 A a 0 C protein NA glycoprotein VIRAL PROTEIN 11/06/24 Crystal structure of diabody CR57 in complex with rabies virus protein G domain III Homo sapiens; Rabies virus CVS-11 homo sapiens rabies virus cvs-11 Kedari, A., Rissanen, I. 2.7 X-RAY DIFFRACTION 0.259 0.217 True True unknown unknown unknown None None None None None 8s79 C NA 0 B protein NA nod-factor receptor 5 PLANT PROTEIN 11/06/24 Lotus japonicus NFR5 intracellular domain in complex with Nanobody 200 Lama glama; Lotus japonicus lama glama lotus japonicus Hansen, S.B., Gysel, K., Andersen, K.R. 2.29 X-RAY DIFFRACTION 0.231 0.196 False True IGHV1 NA NA None None None None None 8s79 D NA 0 A protein NA nod-factor receptor 5 PLANT PROTEIN 11/06/24 Lotus japonicus NFR5 intracellular domain in complex with Nanobody 200 Lama glama; Lotus japonicus lama glama lotus japonicus Hansen, S.B., Gysel, K., Andersen, K.R. 2.29 X-RAY DIFFRACTION 0.231 0.196 False True IGHV1 NA NA None None None None None 8ulh H L 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 11/06/24 Fab of RSV neutralizing antibody 1G12 Homo sapiens homo sapiens homo sapiens Harshbarger, W.D., Andreano, E., Malito, E. 1.69 X-RAY DIFFRACTION 0.228 0.194 False True IGHV1 IGKV2 Kappa None None None None None 8ulj H L 0 B | A protein | protein NA | NA fusion glycoprotein f0,fibritin | fusion glycoprotein f2 VIRAL PROTEIN/IMMUNE SYSTEM 11/06/24 Prefusion RSV F bound by neutralizing antibody 2E08 Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 | respiratory syncytial virus a2 Harshbarger, W.D., Andreano, E., Malito, E. 3 X-RAY DIFFRACTION 0.264 0.237 False True IGHV1 IGKV3 Kappa None None None None None 8vgn A B 0 I protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/06/24 CryoEM structure of CD20 in complex with wild type Rituximab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8vgn H L 0 G protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/06/24 CryoEM structure of CD20 in complex with wild type Rituximab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8vgo A B 0 I protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/06/24 CryoEM structure of CD20 in complex with engineered conformationally rigid Rituximab.4DS Fab Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8vgo H L 0 G protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/06/24 CryoEM structure of CD20 in complex with engineered conformationally rigid Rituximab.4DS Fab Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8wz4 H L 0 C protein NA rsv fusion glycoprotein VIRAL PROTEIN 11/06/24 Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nAb 5B11 (localized refinement) Human respiratory syncytial virus A2; Mus musculus mus musculus mus musculus human respiratory syncytial virus a2 Liu, L., Sun, H., Sun, Y., Zheng, Q., Li, S., Zheng, Z., Xia, N. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV12 Kappa None None None None None 8yh0 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/06/24 A3R-Gi complex bound to NECA Homo sapiens; Influenza A virus (A/Victoria/3/1975(H3N2)); Mus musculus; Ovis aries; Rattus rattus mus musculus homo sapiens | rattus rattus Oshima, H.S., Shihoya, W., Nureki, O. 2.86 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yh2 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/06/24 A3R-Gi complex bound to adenosine Homo sapiens; Human orthopneumovirus; Influenza A virus (A/Victoria/3/1975(H3N2)); Mus musculus; Ovis aries; Rattus rattus mus musculus homo sapiens | rattus rattus Oshima, H.S., Shihoya, W., Nureki, O. 3.27 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yh3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/06/24 A3R-Gi complex bound to m6A Bos taurus; Homo sapiens; human respiratory syncytial virus; Influenza A virus (A/Victoria/3/1975(H3N2)); Mus musculus; Ovis aries; Rattus rattus mus musculus homo sapiens, bos taurus | rattus rattus Oshima, H.S., Shihoya, W., Nureki, O. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yh5 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/06/24 A3R-Gi complex bound to i6A Bos taurus; Homo sapiens; human respiratory syncytial virus; Influenza A virus (A/Victoria/3/1975(H3N2)); Mus musculus; Ovis aries; Rattus rattus mus musculus homo sapiens, bos taurus | rattus rattus Oshima, H.S., Shihoya, W., Nureki, O. 3.66 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yh6 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/06/24 A3R-Gi complex bound to namodenoson Bos taurus; Homo sapiens; human respiratory syncytial virus; Influenza A virus (A/Victoria/3/1975(H3N2)); Mus musculus; Ovis aries; Rattus rattus mus musculus homo sapiens, bos taurus | rattus rattus Oshima, H.S., Shihoya, W., Nureki, O. 3.62 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ywp H L 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of the Fab fragment of anti-IL-6 antibody I9H Homo sapiens homo sapiens homo sapiens Yudenko, A., Bukhdruker, S., Eliseev, I., Rodin, S., Burtseva, A., Petrov, A., Zlobina, O., Ischenko, A., Borshchevskiy, V. 2.5 X-RAY DIFFRACTION 0.285 0.258 False True IGHV2 IGKV1 Kappa None None None None None 8ywq H L 0 A protein NA interleukin-6 IMMUNE SYSTEM 11/06/24 Crystal structure of the Fab fragment of the anti-IL-6 antibody I9H in complex with a domain-swapped IL-6 dimer Homo sapiens homo sapiens homo sapiens homo sapiens Bukhdruker, S., Yudenko, A., Marin, E., Remeeva, A., Rodin, S., Burtseva, A., Petrov, A., Ischenko, A., Borshchevskiy, V. 2.51 X-RAY DIFFRACTION 0.277 0.239 False True IGHV2 IGKV1 Kappa None None None None None 8ywr H L 0 A protein NA interleukin-6 IMMUNE SYSTEM 11/06/24 Crystal structure of the Fab fragment of the anti-IL-6 antibody 68F2 in complex with a domain-swapped IL-6 dimer Homo sapiens; Lama glama lama glama lama glama homo sapiens Bukhdruker, S., Yudenko, A., Borshchevskiy, V. 2.93 X-RAY DIFFRACTION 0.256 0.214 False True IGHV4 IGLV2 Lambda None None None None None 9b8g A B 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 2C9 Fab antibody fragment against the E protein of the Yellow Fever virus Homo sapiens homo sapiens homo sapiens Balk, J., Ting, Y.T., Bibby, S., Watterson, D., Coulibaly, F. 2.66 X-RAY DIFFRACTION 0.258 0.201 False True IGHV5 IGKV14 Kappa None None None None None 9b8g C D 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 2C9 Fab antibody fragment against the E protein of the Yellow Fever virus Homo sapiens homo sapiens homo sapiens Balk, J., Ting, Y.T., Bibby, S., Watterson, D., Coulibaly, F. 2.66 X-RAY DIFFRACTION 0.258 0.201 False True IGHV5 IGKV14 Kappa None None None None None 9b8g H L 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 2C9 Fab antibody fragment against the E protein of the Yellow Fever virus Homo sapiens homo sapiens homo sapiens Balk, J., Ting, Y.T., Bibby, S., Watterson, D., Coulibaly, F. 2.66 X-RAY DIFFRACTION 0.258 0.201 False True IGHV5 IGKV14 Kappa None None None None None 9ctu D C 0 A protein NA membrane protein MEMBRANE PROTEIN 11/06/24 Cryo-EM structure of SARS-CoV-2 M (short conformation)bound to C1P Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Dolan, K.A., Brohawn, S.G. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9ctu F E 0 B protein NA membrane protein MEMBRANE PROTEIN 11/06/24 Cryo-EM structure of SARS-CoV-2 M (short conformation)bound to C1P Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Dolan, K.A., Brohawn, S.G. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9ctw D C 0 A protein NA membrane protein MEMBRANE PROTEIN 11/06/24 Cryo-EM structure of SARS-CoV-2 M (long conformation) in the presence of C1P Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Dolan, K.A., Brohawn, S.G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9ctw F E 0 B protein NA membrane protein MEMBRANE PROTEIN 11/06/24 Cryo-EM structure of SARS-CoV-2 M (long conformation) in the presence of C1P Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Dolan, K.A., Brohawn, S.G. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 9d7y A a 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of scFv corresponding to human autoantibody b96.11 Homo sapiens homo sapiens Buckle, A.M., McGowan, S. 2.6 X-RAY DIFFRACTION 0.301 0.227 True True unknown unknown unknown None None None None None 9d7y B b 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of scFv corresponding to human autoantibody b96.11 Homo sapiens homo sapiens Buckle, A.M., McGowan, S. 2.6 X-RAY DIFFRACTION 0.301 0.227 True True unknown unknown unknown None None None None None 9d7y C c 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of scFv corresponding to human autoantibody b96.11 Homo sapiens homo sapiens Buckle, A.M., McGowan, S. 2.6 X-RAY DIFFRACTION 0.301 0.227 True True unknown unknown unknown None None None None None 9fvb C NA 0 A protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP in complex with a VHH antibody (VHH_VcP#2) Vibrio cholerae; Vicugna pacos vicugna pacos vibrio cholerae Schneberger, N., Hagelueken, G. 2.05 X-RAY DIFFRACTION 0.257 0.195 False True IGHV1 NA NA None None None None None 9fvb H NA 0 B protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP in complex with a VHH antibody (VHH_VcP#2) Vibrio cholerae; Vicugna pacos vicugna pacos vibrio cholerae Schneberger, N., Hagelueken, G. 2.05 X-RAY DIFFRACTION 0.257 0.195 False True IGHV1 NA NA None None None None None 9fvc H NA 0 A protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP in complex with a VHH antibody (VHH_VcP#1) Vibrio cholerae; Vicugna pacos vicugna pacos vibrio cholerae Schneberger, N., Hagelueken, G. 2.64 X-RAY DIFFRACTION 0.254 0.221 False True IGHV1 NA NA None None None None None 9fvc C NA 0 B protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP in complex with a VHH antibody (VHH_VcP#1) Vibrio cholerae; Vicugna pacos vicugna pacos vibrio cholerae Schneberger, N., Hagelueken, G. 2.64 X-RAY DIFFRACTION 0.254 0.221 False True IGHV1 NA NA None None None None None 9fve B NA 0 A protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve D NA 0 C protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve F NA 0 E protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve H NA 0 G protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve J NA 0 I protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve L NA 0 K protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve N NA 0 M protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve P NA 0 O protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve R NA 0 Q protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve T NA 0 Y protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve V NA 0 U protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9fve X NA 0 W protein NA sialic acid-binding periplasmic protein siap TRANSPORT PROTEIN 11/06/24 Crystal structure of VcSiaP W73A mutant in complex with sialic acid and a VHH antibody (VHH_VcP#2) Vicugna pacos vicugna pacos vicugna pacos Schneberger, N., Hagelueken, G. 2.81 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 9ii9 A B 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of SARS-CoV-2 neutralizing antibody K4-66 Homo sapiens homo sapiens homo sapiens Kimura, T.K., Hashiguchi, T. 2.9 X-RAY DIFFRACTION 0.289 0.262 False True IGHV3 IGKV1 Kappa None None None None None 9ii9 C D 0 NA NA NA NA IMMUNE SYSTEM 11/06/24 Crystal structure of SARS-CoV-2 neutralizing antibody K4-66 Homo sapiens homo sapiens homo sapiens Kimura, T.K., Hashiguchi, T. 2.9 X-RAY DIFFRACTION 0.289 0.262 False True IGHV3 IGKV1 Kappa None None None None None 8vgl H L 0 C | B protein | protein NA | NA chimeric nav1.7-navab | chimeric nav1.7-navab TRANSPORT PROTEIN 10/30/24 CryoEM structure of Nav1.7 in complex with wild type Fab 7A9 Aliarcobacter butzleri RM4018; Mus musculus mus musculus mus musculus aliarcobacter butzleri rm4018 | aliarcobacter butzleri rm4018 Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8vgl E F 0 A | D protein | protein NA | NA chimeric nav1.7-navab | chimeric nav1.7-navab TRANSPORT PROTEIN 10/30/24 CryoEM structure of Nav1.7 in complex with wild type Fab 7A9 Aliarcobacter butzleri RM4018; Mus musculus mus musculus mus musculus aliarcobacter butzleri rm4018 | aliarcobacter butzleri rm4018 Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8vgm H L 0 C | D protein | protein NA | NA chimeric nav1.7-navab | chimeric nav1.7-navab TRANSPORT PROTEIN 10/30/24 CryoEM structure of Nav1.7 in complex with engineered conformationally rigid Fab 7A9.4DS Aliarcobacter butzleri RM4018; Mus musculus mus musculus mus musculus aliarcobacter butzleri rm4018 | aliarcobacter butzleri rm4018 Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8vgm E F 0 A | B protein | protein NA | NA chimeric nav1.7-navab | chimeric nav1.7-navab TRANSPORT PROTEIN 10/30/24 CryoEM structure of Nav1.7 in complex with engineered conformationally rigid Fab 7A9.4DS Aliarcobacter butzleri RM4018; Mus musculus mus musculus mus musculus aliarcobacter butzleri rm4018 | aliarcobacter butzleri rm4018 Kung, J.E., Jao, C.C., Arthur, C.P., Sudhamsu, J. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 7lz6 C D 0 A protein NA glutamate decarboxylase 2 IMMUNE SYSTEM 10/30/24 The Cryo-EM structure of a complex between GAD65 and b96.11 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Reboul, C.F., Le, S.N., Williams, D.E., Buckle, A.M. 7.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7lz6 E F 0 B protein NA glutamate decarboxylase 2 IMMUNE SYSTEM 10/30/24 The Cryo-EM structure of a complex between GAD65 and b96.11 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Reboul, C.F., Le, S.N., Williams, D.E., Buckle, A.M. 7.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8rrn H L 0 A protein NA spike protein s1 PROTEIN BINDING 10/30/24 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1616 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 Hansen, G., Krey, T. 3.11 X-RAY DIFFRACTION 0.291 0.243 False True IGHV1 IGLV1 Lambda None None None None None 8rrn C D 0 B protein NA spike protein s1 PROTEIN BINDING 10/30/24 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1616 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 Hansen, G., Krey, T. 3.11 X-RAY DIFFRACTION 0.291 0.243 False True IGHV1 IGLV1 Lambda None None None None None 8us0 N O 0 M protein NA hemagglutinin Viral Protein/IMMUNE SYSTEM 10/30/24 Human antibody S8V1-157 in complex with the A/American black duck/New Brunswick/00464/2010(H4N6) HA head domain Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus McCarthy, K.R. 3.7 X-RAY DIFFRACTION 0.293 0.246 False True IGHV1 IGKV2 Kappa None None None None None 8us0 H I 0 G protein NA hemagglutinin Viral Protein/IMMUNE SYSTEM 10/30/24 Human antibody S8V1-157 in complex with the A/American black duck/New Brunswick/00464/2010(H4N6) HA head domain Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus McCarthy, K.R. 3.7 X-RAY DIFFRACTION 0.293 0.246 False True IGHV1 IGKV2 Kappa None None None None None 8us0 B C 0 A protein NA hemagglutinin Viral Protein/IMMUNE SYSTEM 10/30/24 Human antibody S8V1-157 in complex with the A/American black duck/New Brunswick/00464/2010(H4N6) HA head domain Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus McCarthy, K.R. 3.7 X-RAY DIFFRACTION 0.293 0.246 False True IGHV1 IGKV2 Kappa None None None None None 8us0 Q R 0 P protein NA hemagglutinin Viral Protein/IMMUNE SYSTEM 10/30/24 Human antibody S8V1-157 in complex with the A/American black duck/New Brunswick/00464/2010(H4N6) HA head domain Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus McCarthy, K.R. 3.7 X-RAY DIFFRACTION 0.293 0.246 False True IGHV1 IGKV2 Kappa None None None None None 8us0 E F 0 D protein NA hemagglutinin Viral Protein/IMMUNE SYSTEM 10/30/24 Human antibody S8V1-157 in complex with the A/American black duck/New Brunswick/00464/2010(H4N6) HA head domain Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus McCarthy, K.R. 3.7 X-RAY DIFFRACTION 0.293 0.246 False True IGHV1 IGKV2 Kappa None None None None None 8us0 K L 0 J protein NA hemagglutinin Viral Protein/IMMUNE SYSTEM 10/30/24 Human antibody S8V1-157 in complex with the A/American black duck/New Brunswick/00464/2010(H4N6) HA head domain Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus McCarthy, K.R. 3.7 X-RAY DIFFRACTION 0.293 0.246 False True IGHV1 IGKV2 Kappa None None None None None 8us8 H L 0 R peptide NA ring-infected erythrocyte surface antigen peptide IMMUNE SYSTEM 10/30/24 Crystal structure of B1E11K malarial antibody in complex with RESA repeat peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Yoo, R., Julien, J.P. 2.56 X-RAY DIFFRACTION 0.248 0.216 False True IGHV3 IGKV3 Kappa None None None None None 8us8 A B 0 R peptide NA ring-infected erythrocyte surface antigen peptide IMMUNE SYSTEM 10/30/24 Crystal structure of B1E11K malarial antibody in complex with RESA repeat peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Yoo, R., Julien, J.P. 2.56 X-RAY DIFFRACTION 0.248 0.216 False True IGHV3 IGKV3 Kappa None None None None None 8uxv N NA 0 X | Y protein | protein NA | NA minigs399 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/30/24 Consensus olfactory receptor consOR51 in complex with mini-Gs trimeric protein Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens Billesboelle, C.B., Del Torrent, C.L., Manglik, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8uxy N NA 0 X | Y protein | protein NA | NA gnas complex locus | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/30/24 Consensus olfactory receptor consOR1 bound to L-menthol and in complex with mini-Gs trimeric protein Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens Billesboelle, C.B., Del Torrent, C.L., Manglik, A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8uy0 N NA 0 X | Y | Z protein | protein | protein NA | NA | NA minigs399 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 10/30/24 Consensus olfactory receptor consOR2 bound to S-carvone and in complex with mini-Gs trimeric protein Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Billesboelle, C.B., Del Torrent, C.L., Manglik, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8uyq N NA 0 X | Y | Z protein | protein | protein NA | NA | NA gnas complex locus | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 10/30/24 Consensus olfactory receptor consOR4 bound to 2-methylthiazoline and in complex with mini-Gs trimeric protein Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens | homo sapiens | homo sapiens Billesboelle, C.B., Del Torrent, C.L., Manglik, A. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8veg B A 0 NA NA NA NA IMMUNE SYSTEM 10/30/24 Crystal structure of an engineered conformationally rigid anti-Tryptase Fab variant E104.v1.4DS.S112F Homo sapiens homo sapiens homo sapiens Kung, J.E., Sudhamsu, J. 2 X-RAY DIFFRACTION 0.237 0.209 False True IGHV4 IGKV1 Kappa None None None None None 8vge H L 0 NA NA NA NA IMMUNE SYSTEM 10/30/24 Crystal structure of an engineered conformationally rigid anti-Tryptase Fab variant E104.v1.4DS.A114F Homo sapiens homo sapiens homo sapiens Kung, J.E., Sudhamsu, J. 2.01 X-RAY DIFFRACTION 0.234 0.209 False True IGHV4 IGKV1 Kappa None None None None None 8vgf H L 0 NA NA NA NA IMMUNE SYSTEM 10/30/24 Crystal structure of an engineered conformationally rigid anti-Tryptase Fab variant E104.v1.5DS Homo sapiens homo sapiens homo sapiens Kung, J.E., Sudhamsu, J. 2.14 X-RAY DIFFRACTION 0.219 0.179 False True IGHV4 IGKV1 Kappa None None None None None 8vgg H L 0 NA NA NA NA IMMUNE SYSTEM 10/30/24 Crystal structure of an engineered conformationally rigid anti-Tryptase Fab variant E104.v1.6DS Homo sapiens homo sapiens homo sapiens Kung, J.E., Sudhamsu, J. 2.71 X-RAY DIFFRACTION 0.258 0.207 False True IGHV4 IGKV1 Kappa None None None None None 8vgh H G 0 A protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with wild type anti-tryptase Fab E104.v1 Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgh F E 0 C protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with wild type anti-tryptase Fab E104.v1 Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgh J I 0 B protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with wild type anti-tryptase Fab E104.v1 Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgh K L 0 D protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with wild type anti-tryptase Fab E104.v1 Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgi F E 0 C protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.2DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgi H G 0 A protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.2DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgi J I 0 B protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.2DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgi K L 0 D protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.2DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgj F E 0 C protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.4DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgj H G 0 A protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.4DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgj J I 0 B protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.4DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgj K L 0 D protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.4DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgk F E 0 C protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.6DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgk H G 0 A protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.6DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgk J I 0 B protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.6DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgk K L 0 D protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 10/30/24 CryoEM structure of tryptase in complex with engineered conformationally rigid anti-tryptase Fab E104.v1.6DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Johnson, M.C., Sudhamsu, J. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vgp H L 0 A protein NA angiopoietin-2 CYTOKINE/IMMUNE SYSTEM 10/30/24 CryoEM structure of Angiopoietin-2 in complex with engineered conformationally rigid Fab 5A12.6DS Homo sapiens homo sapiens homo sapiens homo sapiens Kung, J.E., Sudhamsu, J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vhf N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1, hibit MEMBRANE PROTEIN/SIGNALING PROTEIN 10/30/24 Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982 Escherichia coli; Homo sapiens; Lama glama; Oplophorus gracilirostris lama glama homo sapiens | homo sapiens Kim, D.-G., Cherezov, V. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xgo D d 0 E | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 10/30/24 a peptide receptor complex structure Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Wu, Z., Du, Y., Chen, G. 2.68 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xgs D d 0 E | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 10/30/24 a peptide receptor complex structure Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Wu, Z., Du, Y., Chen, G. 2.95 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xgu S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 10/30/24 a peptide receptor complex structure Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Wu, Z., Du, Y., Chen, G. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9fkd H L 0 B protein NA de novo designed dbpro1156_2 binder DE NOVO PROTEIN 10/30/24 Progesterone-bound DB3 Fab in complex with computationally designed DBPro1156_2 protein binder synthetic construct synthetic construct synthetic construct synthetic construct Pacesa, M., Marchand, A., Correia, B.E. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV1 Kappa None None None None None 9fkd I K 0 NA NA NA NA DE NOVO PROTEIN 10/30/24 Progesterone-bound DB3 Fab in complex with computationally designed DBPro1156_2 protein binder synthetic construct synthetic construct synthetic construct Pacesa, M., Marchand, A., Correia, B.E. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV6 Kappa None None None None None 9fww B NA 0 A protein NA natural cytotoxicity triggering receptor 3 IMMUNE SYSTEM 10/30/24 Human NKp30 in complex with a VHH variant Homo sapiens homo sapiens homo sapiens Musil, D., Freire, F. 1.844 X-RAY DIFFRACTION 0.208 0.199 False True IGHV1 NA NA None None None None None 9fxf A NA 0 NA NA NA NA IMMUNE SYSTEM 10/30/24 VHH variant adression natural cytotoxicity triggering receptor 3 Homo sapiens homo sapiens Musil, D., Freire, F. 1.067 X-RAY DIFFRACTION 0.206 0.193 False True IGHV1 NA NA None None None None None 9jub B C 0 A protein NA hyaluronidase ph-20 HYDROLASE/IMMUNE SYSTEM 10/30/24 Cryo-EM structure of human hyaluronidase PH-20 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Im, S.-B., Jeong, T.-K., Kim, N., Oh, B.-H. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8s6m H L 0 R protein NA spike protein s1 VIRAL PROTEIN 10/23/24 SARS-CoV-2 BQ.1.1 RBD bound to the S2V29 and the S2H97 Fab fragments Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Errico, J.M., Park, Y.J., Rietz, T., Czudnochowski, N., Nix, J.C., Cameroni, E., Corti, D., Snell, G., Marco, A.D., Pinto, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 1.67 X-RAY DIFFRACTION 0.203 0.184 False True IGHV3 IGLV2 Lambda None None None None None 8s6m I M 0 R protein NA spike protein s1 VIRAL PROTEIN 10/23/24 SARS-CoV-2 BQ.1.1 RBD bound to the S2V29 and the S2H97 Fab fragments Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Errico, J.M., Park, Y.J., Rietz, T., Czudnochowski, N., Nix, J.C., Cameroni, E., Corti, D., Snell, G., Marco, A.D., Pinto, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 1.67 X-RAY DIFFRACTION 0.203 0.184 False True IGHV5 IGLV2 Lambda None None None None None 8via H L 0 D | C protein | protein NA | NA spike protein s1 | spike protein s2 IMMUNE SYSTEM 10/23/24 Protective effect of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Bajic, G. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8yhz H L 0 P peptide NA sodium channel protein type 9 subunit alpha MEMBRANE PROTEIN/IMMUNE SYSTEM 10/23/24 The co-crystal structure of the Fab fragment of Ab-1080 with NaV1.7 VSDII peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Juanjuan, D., Yaning, Z., Rui, Z., Yanchao, D. 1.62 X-RAY DIFFRACTION 0.210 0.194 False True IGHV1 IGKV1 Kappa None None None None None 9gwt H L 0 P protein NA isoform 1 of cell surface glycoprotein cd200 receptor 1 ANTITUMOR PROTEIN 10/23/24 crystal structure of 23ME-00610 Fab in complex with human CD200R1 Homo sapiens homo sapiens homo sapiens homo sapiens Huang, Y.M., Ganichkin, O.M. 2.89 X-RAY DIFFRACTION 0.236 0.202 False True IGHV4 IGKV3 Kappa None None None None None 8udr D E 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a alpha chain | gtpase kras, n-terminally processed IMMUNE SYSTEM 10/16/24 Structure of the P1B7 antibody bound to the Sotorasib-modified KRas G12C peptide presented by the A*03:01 MHC I complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Chan, L.M., Roweder, P.J., Craik, C.S., Verba, K.A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 9au2 D I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/16/24 VIR-7229 Fab fragment bound the BA.2.86 spike trimer (global refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Park, Y.J., Veelser, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9au2 F J 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/16/24 VIR-7229 Fab fragment bound the BA.2.86 spike trimer (global refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Park, Y.J., Veelser, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9bia E NA 0 B | D protein | protein NA | NA ninjurin-1 | ninjurin-1 MEMBRANE PROTEIN 10/16/24 Cryo-EM structure of NINJ1 K45Q bound to Nb538 Mus musculus; synthetic construct synthetic construct mus musculus | mus musculus Pourmal, S., Johnson, M.C., Deshpande, I. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9bia F NA 0 C | A protein | protein NA | NA ninjurin-1 | ninjurin-1 MEMBRANE PROTEIN 10/16/24 Cryo-EM structure of NINJ1 K45Q bound to Nb538 Mus musculus; synthetic construct synthetic construct mus musculus | mus musculus Pourmal, S., Johnson, M.C., Deshpande, I. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8rek H L 0 A protein NA apical membrane antigen 1 (fragment) IMMUNE SYSTEM 10/16/24 Plasmodium vivax Apical Membrane Antigen 1/Fab complex Mus musculus; Plasmodium vivax Sal-1 mus musculus mus musculus plasmodium vivax sal-1 Bentley, G.A., Saul, F.A., Vulliez-LeNormand, B. 3.05 X-RAY DIFFRACTION 0.292 0.221 False False IGHV5 IGKV4 Kappa None None None None None 8rel H L 0 NA NA NA NA IMMUNE SYSTEM 10/16/24 Fab of an anti-PvAMA1 monoclonal antibody Mus musculus mus musculus mus musculus Bentley, G.A., Saul, F.A., Vulliez-LeNormand, B. 2.1 X-RAY DIFFRACTION 0.255 0.200 False False IGHV5 IGKV4 Kappa None None None None None 8rel M N 0 NA NA NA NA IMMUNE SYSTEM 10/16/24 Fab of an anti-PvAMA1 monoclonal antibody Mus musculus mus musculus mus musculus Bentley, G.A., Saul, F.A., Vulliez-LeNormand, B. 2.1 X-RAY DIFFRACTION 0.255 0.200 False False IGHV5 IGKV4 Kappa None None None None None 8up2 A B 0 C protein NA factor h binding protein, sequence variant id 1 IMMUNE SYSTEM 10/16/24 Murine Fab JAR 4 bound to meningococcal Factor H binding protein Mus musculus; Neisseria meningitidis mus musculus mus musculus neisseria meningitidis Beernink, P.T., Beernink, B.P. 1.6 X-RAY DIFFRACTION 0.212 0.187 False True IGHV1 IGKV1 Kappa None None None None None 8up2 D E 0 F protein NA factor h binding protein, sequence variant id 1 IMMUNE SYSTEM 10/16/24 Murine Fab JAR 4 bound to meningococcal Factor H binding protein Mus musculus; Neisseria meningitidis mus musculus mus musculus neisseria meningitidis Beernink, P.T., Beernink, B.P. 1.6 X-RAY DIFFRACTION 0.212 0.187 False True IGHV1 IGKV1 Kappa None None None None None 8ux6 D C 0 F peptide NA p67 protein IMMUNE SYSTEM 10/16/24 Structure of Fab201 with a T. parva sporozoite neutralizing B cell epitope of p67 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens theileria parva strain muguga Singer, A.U., Gopalsamy, A., Fellouse, F.A., Miersch, S., Sidhu, S.S. 2 X-RAY DIFFRACTION 0.251 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8ux6 B A 0 E peptide NA p67 protein IMMUNE SYSTEM 10/16/24 Structure of Fab201 with a T. parva sporozoite neutralizing B cell epitope of p67 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens theileria parva strain muguga Singer, A.U., Gopalsamy, A., Fellouse, F.A., Miersch, S., Sidhu, S.S. 2 X-RAY DIFFRACTION 0.251 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8vlt H L 0 NA NA NA NA IMMUNE SYSTEM 10/16/24 Crystal structure of glycan-targeting antibody 2526 Fab bound to Mannose Homo sapiens homo sapiens homo sapiens Lindenberger, J., Acharya, P. 1.84 X-RAY DIFFRACTION 0.247 0.201 False True IGHV5 IGKV2 Kappa None None None None None 8wpw A B 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 10/16/24 Cryo-EM structure of SARS-CoV-2 XBB.1.5 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Su, C., Qi, J.X., Gao, G.F. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8wpw C D 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 10/16/24 Cryo-EM structure of SARS-CoV-2 XBB.1.5 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Su, C., Qi, J.X., Gao, G.F. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wpw H L 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 10/16/24 Cryo-EM structure of SARS-CoV-2 XBB.1.5 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Su, C., Qi, J.X., Gao, G.F. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wpy A B 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 10/16/24 Cryo-EM structure of SARS-CoV-2 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Su, C., Qi, J.X., Gao, G.F. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8wpy C D 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 10/16/24 Cryo-EM structure of SARS-CoV-2 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Su, C., Qi, J.X., Gao, G.F. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wpy H L 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 10/16/24 Cryo-EM structure of SARS-CoV-2 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Su, C., Qi, J.X., Gao, G.F. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9asd H L 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/16/24 VIR-7229 Fab fragment bound the SARS-CoV-2 BA.2.86 spike trimer (local refinement of the BA 2.86 RBD/VIR-7229 VHVL) Homo sapiens homo sapiens homo sapiens homo sapiens Park, Y.J., Tortorici, M.A., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 9atm H L 0 R protein NA sars-cov-2 eg.5 rbd VIRAL PROTEIN 10/16/24 SARS-CoV-2 EG.5 RBD bound to the VIR-7229 and the S2H97 Fab fragments Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rietz, T., Park, Y.J., Errico, J., Czudnochowski, N., Nix, J.C., Corti, D., Snell, G., Marco, A.D., Pinto, D., Cameroni, E., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 1.9 X-RAY DIFFRACTION 0.227 0.194 False True IGHV3 IGLV2 Lambda None None None None None 9atm I M 0 R protein NA sars-cov-2 eg.5 rbd VIRAL PROTEIN 10/16/24 SARS-CoV-2 EG.5 RBD bound to the VIR-7229 and the S2H97 Fab fragments Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rietz, T., Park, Y.J., Errico, J., Czudnochowski, N., Nix, J.C., Corti, D., Snell, G., Marco, A.D., Pinto, D., Cameroni, E., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 1.9 X-RAY DIFFRACTION 0.227 0.194 False True IGHV5 IGLV2 Lambda None None None None None 9au1 M N 0 R protein NA sars-cov-2 xbb.1.5 rbd VIRAL PROTEIN 10/16/24 SARS-CoV-2 XBB.1.5 RBD bound to the VIR-7229 and the S309 Fab fragments Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rietz, T., Park, Y.J., Errico, J., Czudnochowski, N., Nix, J.C., Corti, D., Snell, G., Marco, A.D., Pinto, D., Cameroni, E., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D., Structural Genomics Consortium (SGC) 2.41 X-RAY DIFFRACTION 0.257 0.227 False True IGHV1 IGKV3 Kappa None None None None None 9au1 H L 0 R protein NA sars-cov-2 xbb.1.5 rbd VIRAL PROTEIN 10/16/24 SARS-CoV-2 XBB.1.5 RBD bound to the VIR-7229 and the S309 Fab fragments Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rietz, T., Park, Y.J., Errico, J., Czudnochowski, N., Nix, J.C., Corti, D., Snell, G., Marco, A.D., Pinto, D., Cameroni, E., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D., Structural Genomics Consortium (SGC) 2.41 X-RAY DIFFRACTION 0.257 0.227 False True IGHV3 IGLV2 Lambda None None None None None 9jkq N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/16/24 Cryo-EM structure of the METH-bound hTAAR1-Gs complex Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Lin, Y., Wang, J., Shi, F. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9jr2 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-1(minigq) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/16/24 Cryo-EM structure of PTH-PTH1R-Gq (upright state) Bos taurus; Homo sapiens; Mus musculus; Rattus rattus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | rattus rattus Sano, F.K., Hirano, H., Itoh, Y., Nureki, O. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9jr3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1(minigq) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/16/24 Cryo-EM structure of PTH-PTH1R-Gq (tilted state) Bos taurus; Homo sapiens; Mus musculus; Rattus rattus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | rattus rattus Sano, F.K., Hirano, H., Itoh, Y., Nureki, O. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8y0q H L 0 2 protein NA vp2 of capsid protein VIRUS/IMMUNE SYSTEM 10/09/24 Complex of FMDV O/18074 and inter-serotype broadly neutralizing antibodies pOA-2 Foot-and-mouth disease virus O; Sus scrofa sus scrofa sus scrofa foot-and-mouth disease virus o Wu, S., Lei, D. 2.44 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8y0r H L 0 2 protein NA vp2 of capsid protein VIRUS/IMMUNE SYSTEM 10/09/24 Complex of FMDV A/WH/CHA/09 and inter-serotype broadly neutralizing antibodies pOA-2 Foot-and-mouth disease virus A; Sus scrofa sus scrofa sus scrofa foot-and-mouth disease virus a Wu, S., Lei, D. 2.52 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8k18 C D 0 E protein NA spike protein s1 VIRAL PROTEIN 10/09/24 Neutralization antibody ZCP4C9 bound with SARS-CoV-2 Omicron BA.5 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Bingjie, T., Shangyu, D. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8k19 A B 0 E protein NA spike protein s1 VIRAL PROTEIN 10/09/24 Neutralization antibody ZCP3B4 bound with SARS-CoV-2 Omicron BA.5 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tang, B., Dang, S. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8v5l H L 0 A protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 Structure of the Varicella Zoster Virus (VZV) gI binding domain of glycoprotein E (gE) in complex with human Fab 1A2 and 1E12 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Seraj, N., Holzapfel, G., Harshbarger, W. 3.09 X-RAY DIFFRACTION 0.269 0.233 False True IGHV1 IGKV1 Kappa None None None None None 8v5l B C 0 A protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 Structure of the Varicella Zoster Virus (VZV) gI binding domain of glycoprotein E (gE) in complex with human Fab 1A2 and 1E12 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Seraj, N., Holzapfel, G., Harshbarger, W. 3.09 X-RAY DIFFRACTION 0.269 0.233 False True IGHV4 IGLV1 Lambda None None None None None 8v5p H L 0 A protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 Crystal Structure of the C-terminal domain of the VZV gE ectodomain in complex with the Fab of human antibody 5A2 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Harshbarger, W., Malito, E. 4.33 X-RAY DIFFRACTION 0.272 0.222 False True IGHV4 IGKV1 Kappa None None None None None 8v5p E Y 0 D protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 Crystal Structure of the C-terminal domain of the VZV gE ectodomain in complex with the Fab of human antibody 5A2 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Harshbarger, W., Malito, E. 4.33 X-RAY DIFFRACTION 0.272 0.222 False True IGHV4 IGKV1 Kappa None None None None None 8v5p J X 0 G protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 Crystal Structure of the C-terminal domain of the VZV gE ectodomain in complex with the Fab of human antibody 5A2 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Harshbarger, W., Malito, E. 4.33 X-RAY DIFFRACTION 0.272 0.222 False True IGHV4 IGKV1 Kappa None None None None None 8v5p F I 0 C protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 Crystal Structure of the C-terminal domain of the VZV gE ectodomain in complex with the Fab of human antibody 5A2 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Harshbarger, W., Malito, E. 4.33 X-RAY DIFFRACTION 0.272 0.222 False True IGHV4 IGKV1 Kappa None None None None None 8v5s H L 0 C protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 VZV glycoprotein E C-terminal domain (cleaved) in complex with human Fab 5A2 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Harshbarger, W., Malito, E. 3.53 X-RAY DIFFRACTION 0.307 0.261 False True IGHV4 IGKV1 Kappa None None None None None 8v5s A B 0 D protein NA envelope glycoprotein e VIRAL PROTEIN 10/09/24 VZV glycoprotein E C-terminal domain (cleaved) in complex with human Fab 5A2 Homo sapiens; Human alphaherpesvirus 3 homo sapiens homo sapiens human alphaherpesvirus 3 Harshbarger, W., Malito, E. 3.53 X-RAY DIFFRACTION 0.307 0.261 False True IGHV4 IGKV1 Kappa None None None None None 8vdl H L 0 C protein NA hb3var03 cidra1.4 domain IMMUNE SYSTEM 10/09/24 HB3VAR03 CIDRa1.4 domain with C7 Fab Homo sapiens; Plasmodium falciparum HB3 homo sapiens homo sapiens plasmodium falciparum hb3 Hurlburt, N.K., Pancera, M. 2.68 X-RAY DIFFRACTION 0.266 0.217 False True IGHV3 IGLV3 Lambda None None None None None 8vqd C B 0 A protein NA receptor tyrosine-protein kinase erbb-2/higg1 fc domainfusion SIGNALING PROTEIN 10/09/24 HER2 S310F in complex with TL1 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Bang, I., Koide, S. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8yn2 E e 0 A | B protein | protein NA | NA engineered guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/09/24 Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Liu, G., Li, X., Gong, W. 2.66 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yn3 N NA 0 A | B protein | protein NA | NA engineered guanine nucleotide,binding protein g(s) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/09/24 Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGs Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Liu, G., Li, X., Gong, W. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8yn4 E e 0 A | B protein | protein NA | NA engineered guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/09/24 Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Liu, G., Li, X., Gong, W. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yn5 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/09/24 Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhang, X., Liu, G., Li, X., Gong, W. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yn6 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/09/24 Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhang, X., Liu, G., Li, X., Gong, W. 2.77 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yn9 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/09/24 Cryo-EM structure of histamine H4 receptor in complex with histamine and Gi Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Zhang, X., Liu, G., Li, X., Gong, W. 2.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9gyo N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/09/24 CryoEM structure of Gs-coupled GPBAR with small molecule agonist P395 Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Frechard, A., Brooks, I. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8vsj H L 0 A | B protein | protein NA | NA hla class ii histocompatibility antigen, dr alpha chain | hla class ii histocompatibility antigen dr beta chain IMMUNE SYSTEM 10/02/24 Engineered peptide-specific binder in complex with HLA-DR1/CLIP Homo sapiens; Metamycoplasma arthritidis homo sapiens homo sapiens homo sapiens | homo sapiens Jude, K.M., Yang, X., Du, H., Kassardjian, A., Julien, J.-P., Huang, P., Garcia, K.C. 2.28 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV9 Kappa None None None None None 8s4u B NA 0 A protein NA thiamine transporter 2 MEMBRANE PROTEIN 10/02/24 Cryo-EM structure of apo human SLC19A3 in outward-open state Homo sapiens; Lama glama lama glama homo sapiens Gabriel, F., Loew, C. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8s5u B NA 0 A protein NA thiamine transporter 2 MEMBRANE PROTEIN 10/02/24 Cryo-EM structure of thiamine-bound human SLC19A3 in outward-open state Homo sapiens; Lama glama lama glama homo sapiens Gabriel, F., Loew, C. 3.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8s5w B NA 0 A protein NA thiamine transporter 2 MEMBRANE PROTEIN 10/02/24 Cryo-EM structure of fedratinib-bound human SLC19A3 in inward-open state Homo sapiens; Lama glama lama glama homo sapiens Gabriel, F., Loew, C. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8s61 B NA 0 A protein NA thiamine transporter 2 MEMBRANE PROTEIN 10/02/24 Cryo-EM structure of thiamine-bound human SLC19A3 in inward-open state Homo sapiens; Lama glama lama glama homo sapiens Gabriel, F., Loew, C. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8vdf H L 0 A protein NA erythrocyte membrane protein 1 IMMUNE SYSTEM 10/02/24 Cryo-EM structure of human monoclonal antibody C7 targeting IT4VAR22 CIDRa1.7 (PfEMP1 A) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Raghavan, S.S.R., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8vdg H K 0 A protein NA erythrocyte membrane protein 1 IMMUNE SYSTEM 10/02/24 Cryo-EM structure of human monoclonal antibody C74 targeting IT4VAR22 CIDRa1.7 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Raghavan, S.S.R., Ward, A.B. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8vgv C D 0 A protein NA ch848 de3 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 DH270.6 Fab bound to the HIV-1 CH848 DE3 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8vgv G H 0 E protein NA ch848 de3 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 DH270.6 Fab bound to the HIV-1 CH848 DE3 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8vgv K L 0 I protein NA ch848 de3 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 DH270.6 Fab bound to the HIV-1 CH848 DE3 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8vgw C D 0 A protein NA ch848 de3 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 VRC01 Fab bound to the HIV-1 CH848 DE3 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8vgw G H 0 E protein NA ch848 de3 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 VRC01 Fab bound to the HIV-1 CH848 DE3 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8vgw K L 0 I protein NA ch848 de3 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 VRC01 Fab bound to the HIV-1 CH848 DE3 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8vh1 C D 0 A protein NA ch505.m5 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 4.08 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8vh1 G H 0 E protein NA ch505.m5 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 4.08 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8vh1 K L 0 I protein NA ch505.m5 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/02/24 CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 4.08 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8wjx N NA 0 A | B protein | protein NA | NA gnas complex locus | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/02/24 ADP-bound purinergic receptor 1 in complex with miniGs/q Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Gu, Q.C., Tang, W.Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xwp D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/02/24 Cryo-EM structure of ET-1 bound ETBR-DNGI complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Tani, K., Maki-Yonekura, S., Kanno, R., Negami, T., Hamaguchi, T., Hall, M., Mizoguchi, A., Humbel, B.M., Terada, T., Yonekura, K., Doi, T. 3.21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xwq D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/02/24 Cryo-EM structure of ET-1 bound ETBR-DNGI complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Tani, K., Maki-Yonekura, S., Kanno, R., Negami, T., Hamaguchi, T., Hall, M., Mizoguchi, A., Humbel, B.M., Terada, T., Yonekura, K., Doi, T. 4.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9axn H L 0 H Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axn A B 0 A Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axn C D 0 C Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axn E F 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axn I J 0 I Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axn M N 0 M Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axn O P 0 O Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axn Q R 0 R Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Anti-Fentanyl Antibody HY11-6B2_Mu Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.4 X-RAY DIFFRACTION 0.263 0.224 False True IGHV1 IGKV6 Kappa None None None None None 9axo H L 0 L Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of Antibody HY11-7E1_Ch2 Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M. 2.1 X-RAY DIFFRACTION 0.278 0.232 False True IGHV1 IGKV6 Kappa None None None None None 9axq H L 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of HY11-7E1_Hu3 Fab in the Apo Conformation Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M., Hannon, B. 2.2 X-RAY DIFFRACTION 0.238 0.208 False True IGHV1 IGKV1 Kappa None None None None None 9axq A B 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of HY11-7E1_Hu3 Fab in the Apo Conformation Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M., Hannon, B. 2.2 X-RAY DIFFRACTION 0.238 0.208 False True IGHV1 IGKV1 Kappa None None None None None 9axq C D 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of HY11-7E1_Hu3 Fab in the Apo Conformation Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M., Hannon, B. 2.2 X-RAY DIFFRACTION 0.238 0.208 False True IGHV1 IGKV1 Kappa None None None None None 9axq E F 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of HY11-7E1_Hu3 Fab in the Apo Conformation Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M., Hannon, B. 2.2 X-RAY DIFFRACTION 0.238 0.208 False True IGHV1 IGKV1 Kappa None None None None None 9axr A B 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of HY18-5B1_Ch Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus McGovern, M.R., Rodarte, J.V., Pancera, M. 3.3 X-RAY DIFFRACTION 0.316 0.278 False True IGHV14 IGKV6 Kappa None None None None None 9axr H L 0 H Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 10/02/24 Crystal Structure of HY18-5B1_Ch Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus mus musculus McGovern, M.R., Rodarte, J.V., Pancera, M. 3.3 X-RAY DIFFRACTION 0.316 0.278 False True IGHV14 IGKV6 Kappa None None None None None 9axr C D 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of HY18-5B1_Ch Fab in Complex with Fentanyl Mus musculus mus musculus mus musculus McGovern, M.R., Rodarte, J.V., Pancera, M. 3.3 X-RAY DIFFRACTION 0.316 0.278 False True IGHV14 IGKV6 Kappa None None None None None 9axs H L 0 NA NA NA NA IMMUNE SYSTEM 10/02/24 Crystal Structure of HY18-5B1_Ch Fab in the Apo Conformation Mus musculus mus musculus mus musculus McGovern, M.R., Rodarte, J.V., Pancera, M. 2.04 X-RAY DIFFRACTION 0.235 0.200 False True IGHV14 IGKV6 Kappa None None None None None 9bhb H K 0 A protein NA erythrocyte membrane protein 1, pfemp1 IMMUNE SYSTEM 10/02/24 Cryo-EM structure of human monoclonal antibody C74 targeting PFD1235w (CIDRa1.6) PfEMP1 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Raghavan, S.S.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9ew2 N NA 0 A | B protein | protein NA | NA gnas complex locus,isoform 4 of guanine nucleotide-bindingprotein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/02/24 High resolution structure of FZD7 in complex with miniGs protein Homo sapiens homo sapiens homo sapiens | homo sapiens Bous, J., Kinsolving, J., Gratz, L., Scharf, M.M., Voss, J., Selcuk, B., Adebali, O., Schulte, G. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9g5k B NA 0 A protein NA thiamine transporter 2 MEMBRANE PROTEIN 10/02/24 Cryo-EM structure of apo human SLC19A3 in inward-open state Homo sapiens; Lama glama lama glama homo sapiens Gabriel, F., Loew, C. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9iqt E e 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN/IMMUNE SYSTEM 10/02/24 structure of niacin-HCA2-Gi Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Liu, Y., Zhou, Z. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8qj2 N NA 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/25/24 Structure of active state MC4R in complex with a potent ligand mimicking nanobody Discosoma sp.; Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Busch, A., Jaakola, V.-P., Masiulis, S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8qj2 D NA 0 A protein NA soluble cytochrome b562,melanocortin receptor 4,redfluorescent protein drfp583 MEMBRANE PROTEIN 09/25/24 Structure of active state MC4R in complex with a potent ligand mimicking nanobody Discosoma sp.; Escherichia coli; Homo sapiens; Lama glama lama glama escherichia coli, homo sapiens, discosoma sp. Busch, A., Jaakola, V.-P., Masiulis, S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8r38 H L 0 S carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 09/25/24 BIIG2 anti-integrin Fab Rattus norvegicus rattus norvegicus rattus norvegicus Cordara, G., Heim, J.B., Johannesen, H., Krengel, U. 1.38 X-RAY DIFFRACTION 0.217 0.195 False True IGHV2 IGKV16 Kappa None None None None None 8uy6 B NA 0 A protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8uy6 D NA 0 C protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8uy6 F NA 0 E protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8uy6 H NA 0 G protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8uy6 J NA 0 I protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8uy6 L NA 0 K protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8uy6 N NA 0 M protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8uy6 P NA 0 O protein NA aquaporin z MEMBRANE PROTEIN 09/25/24 Aquaporin Z with ALFA tag and bound to nanobody Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Stover, L., Bahramimoghaddam, H., Wang, L., Zhou, M., Laganowsky, A. 1.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8weo C NA 0 B protein NA fragilysin TOXIN/IMMUNE SYSTEM 09/25/24 Bacteroides fragilis toxin in complex with neutralization nanobody Bacteroides fragilis; Vicugna pacos vicugna pacos bacteroides fragilis Guo, Y., Wen, Y. 1.5 X-RAY DIFFRACTION 0.197 0.171 False True IGHV1 NA NA None None None None None 8weo D NA 0 A protein NA fragilysin TOXIN/IMMUNE SYSTEM 09/25/24 Bacteroides fragilis toxin in complex with neutralization nanobody Bacteroides fragilis; Vicugna pacos vicugna pacos bacteroides fragilis Guo, Y., Wen, Y. 1.5 X-RAY DIFFRACTION 0.197 0.171 False True IGHV1 NA NA None None None None None 8wfh E e 0 A protein NA spike protein s1 VIRAL PROTEIN 09/25/24 Crystal structure of Omicron BA.4/5 in complex with a neutralizing antibody scFv D1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, M., Zhang, N., Gabibov, A., Guo, Y. 2.72 X-RAY DIFFRACTION 0.250 0.211 True True unknown unknown unknown None None None None None 8wfm A a 0 B protein NA spike protein s1 VIRAL PROTEIN 09/25/24 Crystal structure of Omicron BA.1 in complex with a neutralizing antibody scFv T11 Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 Zhang, M., Zhang, N., Gabibov, A., Guo, Y. 2.99 X-RAY DIFFRACTION 0.265 0.215 True True unknown unknown unknown None None None None None 8wfm C c 0 D protein NA spike protein s1 VIRAL PROTEIN 09/25/24 Crystal structure of Omicron BA.1 in complex with a neutralizing antibody scFv T11 Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 Zhang, M., Zhang, N., Gabibov, A., Guo, Y. 2.99 X-RAY DIFFRACTION 0.265 0.215 True True unknown unknown unknown None None None None None 8wfm E e 0 F protein NA spike protein s1 VIRAL PROTEIN 09/25/24 Crystal structure of Omicron BA.1 in complex with a neutralizing antibody scFv T11 Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 Zhang, M., Zhang, N., Gabibov, A., Guo, Y. 2.99 X-RAY DIFFRACTION 0.265 0.215 True True unknown unknown unknown None None None None None 8wfm G g 0 H protein NA spike protein s1 VIRAL PROTEIN 09/25/24 Crystal structure of Omicron BA.1 in complex with a neutralizing antibody scFv T11 Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 Zhang, M., Zhang, N., Gabibov, A., Guo, Y. 2.99 X-RAY DIFFRACTION 0.265 0.215 True True unknown unknown unknown None None None None None 8wrd H L 0 A protein NA synaptic vesicular amine transporter MEMBRANE PROTEIN 09/25/24 Transporter apo state Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Im, D., Iwata, S. 3.05 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 8wre H L 0 A protein NA synaptic vesicular amine transporter MEMBRANE PROTEIN 09/25/24 Transporter bound with dopamine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Im, D., Iwata, S. 2.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 8wvg H L 0 A protein NA synaptic vesicular amine transporter MEMBRANE PROTEIN 09/25/24 Transporter bound with inhibitor Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Im, D., Iwata, S. 3.18 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 8zdw U R 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/25/24 The cryoEM structure of H5N1 HA split from symmetric filament in conformation A Influenza A virus (strain A/Vietnam/1203/2004 H5N1); Mus musculus mus musculus mus musculus influenza a virus (strain a/vietnam/1203/2004h5n1) Li, R., Gao, J., Wang, L., Gui, M., Xiang, Y. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8zdw F E 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/25/24 The cryoEM structure of H5N1 HA split from symmetric filament in conformation A Influenza A virus (strain A/Vietnam/1203/2004 H5N1); Mus musculus mus musculus mus musculus influenza a virus (strain a/vietnam/1203/2004h5n1) Li, R., Gao, J., Wang, L., Gui, M., Xiang, Y. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8zdw L J 0 H protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 09/25/24 The cryoEM structure of H5N1 HA split from symmetric filament in conformation A Influenza A virus (strain A/Vietnam/1203/2004 H5N1); Mus musculus mus musculus mus musculus influenza a virus (strain a/vietnam/1203/2004h5n1) Li, R., Gao, J., Wang, L., Gui, M., Xiang, Y. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8zps E e 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 09/25/24 Cryo-EM structure of prolactin-releasing peptide recognition with Gi Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Zhao, L., Li, Y., Yuan, Q., Xu, H.E. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zpt E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(324) subunit alpha-1, | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/25/24 Cryo-EM structure of prolactin-releasing peptide recognition with Gq Homo sapiens homo sapiens homo sapiens | homo sapiens Zhao, L., Li, Y., Yuan, Q., Xu, H.E. 2.96 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9cj7 H L 0 C | B | A protein | protein | protein NA | NA | NA glycoprotein g2 | glycoprotein g2 | glycoprotein g2 VIRAL PROTEIN/IMMUNE SYSTEM 09/25/24 Lineage IV Lassa virus glycoprotein (Josiah) in complex with monoclonal antibody 8.9F Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah | lassa virus josiah | lassa virus josiah Brouwer, P.J.M., Perrett, H.R., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 9dn4 A B 0 E nucleic-acid NA rna (5'-r(p*cp*up*cp*gp*up*cp*up*gp*ap*ap*ap*cp*ap*cp*gp*gp*ap*gp*ap*g)-3') IMMUNE SYSTEM 09/25/24 Crystal structure of a SARS-CoV-2 20-mer RNA in complex with FAB BL3-6S97N Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Lovell, S., Cooper, A., Battaile, K.P., Hegde, S., Wang, J. 1.9 X-RAY DIFFRACTION 0.223 0.176 False True IGHV3 IGKV1 Kappa None None None None None 9dn4 D C 0 F nucleic-acid NA rna (5'-r(p*cp*up*cp*gp*up*cp*up*gp*ap*ap*ap*cp*ap*cp*gp*gp*ap*gp*ap*g)-3') IMMUNE SYSTEM 09/25/24 Crystal structure of a SARS-CoV-2 20-mer RNA in complex with FAB BL3-6S97N Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Lovell, S., Cooper, A., Battaile, K.P., Hegde, S., Wang, J. 1.9 X-RAY DIFFRACTION 0.223 0.176 False True IGHV3 IGKV1 Kappa None None None None None 9gp2 H L 0 NA NA NA NA ANTITUMOR PROTEIN 09/25/24 apoJ22.9 Unliganded structure of an Fab fragment from the therapeutic antibody J22.9-xi Mus musculus mus musculus mus musculus Marino, S.F., Daumke, O. 1.97 X-RAY DIFFRACTION 0.202 0.162 False True IGHV4 IGKV6 Kappa None None None None None 8rtw B A 0 A Hapten TES TESTOSTERONE IMMUNE SYSTEM 09/18/24 Crystal Structure of the Anti-testosterone Fab in Complex with Testosterone Mus musculus mus musculus mus musculus mus musculus Eronen, V., Parkkinen, T., Hakulinen, N., Rouvinen, J. 1.99 X-RAY DIFFRACTION 0.221 0.190 False True IGHV1 IGKV6 Kappa None None None None None 8rtw D C 0 C Hapten TES TESTOSTERONE IMMUNE SYSTEM 09/18/24 Crystal Structure of the Anti-testosterone Fab in Complex with Testosterone Mus musculus mus musculus mus musculus mus musculus Eronen, V., Parkkinen, T., Hakulinen, N., Rouvinen, J. 1.99 X-RAY DIFFRACTION 0.221 0.190 False True IGHV1 IGKV6 Kappa None None None None None 8rtx B A 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal Structure of an Anti-idiotype Fab Fragment Mus musculus mus musculus mus musculus Eronen, V., Parkkinen, T., Hakulinen, N., Rouvinen, J. 2.7 X-RAY DIFFRACTION 0.269 0.247 False True IGHV3 IGKV1 Kappa None None None None None 8rtx D C 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal Structure of an Anti-idiotype Fab Fragment Mus musculus mus musculus mus musculus Eronen, V., Parkkinen, T., Hakulinen, N., Rouvinen, J. 2.7 X-RAY DIFFRACTION 0.269 0.247 False True IGHV3 IGKV1 Kappa None None None None None 8rtx F E 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal Structure of an Anti-idiotype Fab Fragment Mus musculus mus musculus mus musculus Eronen, V., Parkkinen, T., Hakulinen, N., Rouvinen, J. 2.7 X-RAY DIFFRACTION 0.269 0.247 False True IGHV3 IGKV1 Kappa None None None None None 8tx3 H L 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 09/11/24 Fab 3864-6 in complex with influenza HA H3-VIC11 Homo sapiens; Influenza A virus (A/Victoria/361/2011(H3N2)) homo sapiens homo sapiens influenza a virus (a/victoria/361/2011(h3n2)) | influenza a virus (a/victoria/361/2011(h3n2)) Morano, N.C., Shapiro, L. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 8tx3 E J 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 09/11/24 Fab 3864-6 in complex with influenza HA H3-VIC11 Homo sapiens; Influenza A virus (A/Victoria/361/2011(H3N2)) homo sapiens homo sapiens influenza a virus (a/victoria/361/2011(h3n2)) | influenza a virus (a/victoria/361/2011(h3n2)) Morano, N.C., Shapiro, L. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 8tx3 F K 0 I | G protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 09/11/24 Fab 3864-6 in complex with influenza HA H3-VIC11 Homo sapiens; Influenza A virus (A/Victoria/361/2011(H3N2)) homo sapiens homo sapiens influenza a virus (a/victoria/361/2011(h3n2)) | influenza a virus (a/victoria/361/2011(h3n2)) Morano, N.C., Shapiro, L. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 8txu E J 0 D | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 chain ANTIVIRAL PROTEIN 09/11/24 Fab 3864-10 in complex with influenza HA H3-SING16 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus | influenza a virus Morano, N.C., Shapiro, L. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 8txu F K 0 I | G protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 chain ANTIVIRAL PROTEIN 09/11/24 Fab 3864-10 in complex with influenza HA H3-SING16 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus | influenza a virus Morano, N.C., Shapiro, L. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 8txu H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 chain ANTIVIRAL PROTEIN 09/11/24 Fab 3864-10 in complex with influenza HA H3-SING16 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus | influenza a virus Morano, N.C., Shapiro, L. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 8vut H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with IgG 008-218 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8vut I M 0 C | B protein | protein NA | NA glutamate receptor ionotropic, nmda 1 | glutamate receptor ionotropic, nmda 2a MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with IgG 008-218 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Michalski, K., Furukawa, H. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8s4h A B 0 A Hapten RBR rocuronium IMMUNE SYSTEM 09/18/24 Crystal structure of scFv-1B6 in complex with rocuronium bromide Mus musculus mus musculus mus musculus mus musculus Saul, F.A., Haouz, A., Bruhns, P. 1.7 X-RAY DIFFRACTION 0.188 0.166 False True IGHV1 IGKV2 Kappa None None None None None 8s4h C D 0 C Hapten RBR rocuronium IMMUNE SYSTEM 09/18/24 Crystal structure of scFv-1B6 in complex with rocuronium bromide Mus musculus mus musculus mus musculus mus musculus Saul, F.A., Haouz, A., Bruhns, P. 1.7 X-RAY DIFFRACTION 0.188 0.166 False True IGHV1 IGKV2 Kappa None None None None None 8s4h H L 0 H Hapten RBR rocuronium IMMUNE SYSTEM 09/18/24 Crystal structure of scFv-1B6 in complex with rocuronium bromide Mus musculus mus musculus mus musculus mus musculus Saul, F.A., Haouz, A., Bruhns, P. 1.7 X-RAY DIFFRACTION 0.188 0.166 False True IGHV1 IGKV2 Kappa None None None None None 8s4k H L 0 L Hapten RBR rocuronium IMMUNE SYSTEM 09/18/24 Crystal structure of Fab-2B1 in complex with rocuronium Mus musculus mus musculus mus musculus mus musculus Saul, F.A., Haouz, A., Bruhns, P. 1.6 X-RAY DIFFRACTION 0.206 0.179 False True IGHV1 IGKV2 Kappa None None None None None 8u70 B A 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of malaria transmission-blocking anti-Pfs48/45 antibody RUPA-58. Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Julien, J.P. 3.09 X-RAY DIFFRACTION 0.263 0.223 False True IGHV1 IGKV1 Kappa None None None None None 8u70 D C 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of malaria transmission-blocking anti-Pfs48/45 antibody RUPA-58. Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Julien, J.P. 3.09 X-RAY DIFFRACTION 0.263 0.223 False True IGHV1 IGKV1 Kappa None None None None None 8u70 F E 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of malaria transmission-blocking anti-Pfs48/45 antibody RUPA-58. Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Julien, J.P. 3.09 X-RAY DIFFRACTION 0.263 0.223 False True IGHV1 IGKV1 Kappa None None None None None 8u70 J I 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of malaria transmission-blocking anti-Pfs48/45 antibody RUPA-58. Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Julien, J.P. 3.09 X-RAY DIFFRACTION 0.263 0.223 False True IGHV1 IGKV1 Kappa None None None None None 8u70 L K 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of malaria transmission-blocking anti-Pfs48/45 antibody RUPA-58. Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Julien, J.P. 3.09 X-RAY DIFFRACTION 0.263 0.223 False True IGHV1 IGKV1 Kappa None None None None None 8u70 H G 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of malaria transmission-blocking anti-Pfs48/45 antibody RUPA-58. Homo sapiens homo sapiens homo sapiens Hailemariam, S., Ivanochko, D., Julien, J.P. 3.09 X-RAY DIFFRACTION 0.263 0.223 False True IGHV1 IGKV1 Kappa None None None None None 8vs7 A B 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 2C1 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.41 X-RAY DIFFRACTION 0.254 0.200 False True IGHV1 IGKV6 Kappa None None None None None 8vs7 H L 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 2C1 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.41 X-RAY DIFFRACTION 0.254 0.200 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 A B 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 D C 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV1 IGKV5 Kappa None None None None None 8vs8 E F 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 H G 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV1 IGKV5 Kappa None None None None None 8vs8 I J 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 L K 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV1 IGKV5 Kappa None None None None None 8vs8 M N 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 P O 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV1 IGKV5 Kappa None None None None None 8vs8 Q R 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 T S 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV1 IGKV5 Kappa None None None None None 8vs8 U V 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 X W 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV1 IGKV5 Kappa None None None None None 8vs8 Y Z 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False True IGHV3 IGLV1 Lambda None None None None None 8vs8 b a 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False False IGHV1 IGKV5 Kappa None None None None None 8vs8 c d 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False False IGHV3 IGLV1 Lambda None None None None None 8vs8 f e 0 NA NA NA NA IMMUNE SYSTEM 09/18/24 Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 1D3 Fab Homo sapiens homo sapiens homo sapiens Kher, G., Homad, L.J., McGuire, A.T., Pancera, M. 2.67 X-RAY DIFFRACTION 0.273 0.231 False False IGHV1 IGKV5 Kappa None None None None None 8vym D E 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) in the postfusion conformation in complex with 1G2 and 7H3 Fabs Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8vym G F 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) in the postfusion conformation in complex with 1G2 and 7H3 Fabs Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8vym K H 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) in the postfusion conformation in complex with 1G2 and 7H3 Fabs Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8vym J I 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) in the postfusion conformation in complex with 1G2 and 7H3 Fabs Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8vyn D E 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) stabilized in a prefusion-like conformation in complex with 1G2 and 7H3, composite map (global and local) and model Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8vyn F G 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) stabilized in a prefusion-like conformation in complex with 1G2 and 7H3, composite map (global and local) and model Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8vyn H I 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) stabilized in a prefusion-like conformation in complex with 1G2 and 7H3, composite map (global and local) and model Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8vyn J K 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) stabilized in a prefusion-like conformation in complex with 1G2 and 7H3, composite map (global and local) and model Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8vyn L M 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) stabilized in a prefusion-like conformation in complex with 1G2 and 7H3, composite map (global and local) and model Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8vyn N O 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) stabilized in a prefusion-like conformation in complex with 1G2 and 7H3, composite map (global and local) and model Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8wcg C NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 09/18/24 Crystal structure of SARS-CoV-1 RBD in complex with nanobody aSR29 and aSR347 Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Zeng, W.H., Ma, H., Jin, T.C. 2.599 X-RAY DIFFRACTION 0.279 0.232 False True IGHV1 NA NA None None None None None 8wcg D NA 0 B protein NA asr347 nanobody ANTIVIRAL PROTEIN 09/18/24 Crystal structure of SARS-CoV-1 RBD in complex with nanobody aSR29 and aSR347 Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Zeng, W.H., Ma, H., Jin, T.C. 2.599 X-RAY DIFFRACTION 0.279 0.232 False True IGHV1 NA NA None None None None None 8wcg b NA 0 B protein NA asr347 nanobody ANTIVIRAL PROTEIN 09/18/24 Crystal structure of SARS-CoV-1 RBD in complex with nanobody aSR29 and aSR347 Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Zeng, W.H., Ma, H., Jin, T.C. 2.599 X-RAY DIFFRACTION 0.279 0.232 False False IGHV1 NA NA None None None None None 8wcg E NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 09/18/24 Crystal structure of SARS-CoV-1 RBD in complex with nanobody aSR29 and aSR347 Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Zeng, W.H., Ma, H., Jin, T.C. 2.599 X-RAY DIFFRACTION 0.279 0.232 False True IGHV1 NA NA None None None None None 8xor E e 0 A | B protein | protein NA | NA g subunit q (gi1-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/18/24 Cryo-EM structure of the tethered agonist-bound human PAR1-Gq complex Bos taurus; Homo sapiens; Mus musculus; Rattus mus musculus homo sapiens | rattus Guo, J., Zhang, Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xos E NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/18/24 Cryo-EM structure of the tethered agonist-bound human PAR1-Gi complex Bos taurus; Homo sapiens; Mus musculus; Rattus mus musculus homo sapiens | rattus Guo, J., Zhang, Y. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 NA NA None None None None None 8xps B NA 0 A protein NA nipah virus bangladesh string g protein VIRAL PROTEIN 09/18/24 Structure of Nipah virus Bangladesh string G protein ectodomain monomer bound to single-domain antibody n425 at 3.22 Angstroms overall resolution Henipavirus nipahense; Homo sapiens homo sapiens henipavirus nipahense Sun, L., Chen, Z., Sun, Y., Mao, Q. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xpy B NA 0 A protein NA glycoprotein g VIRAL PROTEIN 09/18/24 Structure of Nipah virus Malaysia string G protein ectodomain monomer bound to single-domain antibody n425 at 3.63 Angstroms overall resolution Henipavirus nipahense; Homo sapiens homo sapiens henipavirus nipahense Sun, L., Chen, Z., Sun, Y., Mao, Q. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xq3 F NA 0 B protein NA nipah virus bangladesh string g protein VIRAL PROTEIN 09/18/24 Structure of Nipah virus Bangladesh string G protein ectodomain tetramer bound to single-domain antibody n425 at 5.87 Angstroms overall resolution Henipavirus nipahense; Homo sapiens homo sapiens henipavirus nipahense Sun, L., Chen, Z., Sun, Y., Mao, Q. 5.87 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xq3 E NA 0 A protein NA nipah virus bangladesh string g protein VIRAL PROTEIN 09/18/24 Structure of Nipah virus Bangladesh string G protein ectodomain tetramer bound to single-domain antibody n425 at 5.87 Angstroms overall resolution Henipavirus nipahense; Homo sapiens homo sapiens henipavirus nipahense Sun, L., Chen, Z., Sun, Y., Mao, Q. 5.87 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xq3 G NA 0 C protein NA nipah virus bangladesh string g protein VIRAL PROTEIN 09/18/24 Structure of Nipah virus Bangladesh string G protein ectodomain tetramer bound to single-domain antibody n425 at 5.87 Angstroms overall resolution Henipavirus nipahense; Homo sapiens homo sapiens henipavirus nipahense Sun, L., Chen, Z., Sun, Y., Mao, Q. 5.87 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xq3 H NA 0 D protein NA nipah virus bangladesh string g protein VIRAL PROTEIN 09/18/24 Structure of Nipah virus Bangladesh string G protein ectodomain tetramer bound to single-domain antibody n425 at 5.87 Angstroms overall resolution Henipavirus nipahense; Homo sapiens homo sapiens henipavirus nipahense Sun, L., Chen, Z., Sun, Y., Mao, Q. 5.87 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8yw3 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 09/18/24 Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Li, W.Z., Zhou, Q.T., Cong, Z.T., Yuan, Q.N., Li, W.X., Zhao, F.H., Xu, H.E., Zhao, L.H., Yang, D.H., Wang, M.W. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8yw4 N NA 0 A | B protein | protein NA | NA mini-gs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 09/18/24 Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Li, W.Z., Zhou, Q.T., Cong, Z.T., Yuan, Q.N., Li, W.X., Zhao, F.H., Xu, H.E., Zhao, L.H., Yang, D.H., Wang, M.W. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ato D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 XBB.1.5 spike/Nanosota-3C complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ato F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 XBB.1.5 spike/Nanosota-3C complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9ato L NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 XBB.1.5 spike/Nanosota-3C complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9atp D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 local refinement of XBB.1.5 spike/Nanosota-3C complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9atp E NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 local refinement of XBB.1.5 spike/Nanosota-3C complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9atp L NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/18/24 local refinement of XBB.1.5 spike/Nanosota-3C complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ukh H L 0 A protein NA cell traversal protein for ookinetes and sporozoites CELL INVASION 09/11/24 Crystal structure of Plasmodium falciparum CelTOS in complex with antibody 4h12 Mus musculus; Plasmodium falciparum 3D7 mus musculus mus musculus plasmodium falciparum 3d7 Tang, W.K., Tolia, N.H., Urusova, D. 3.52 X-RAY DIFFRACTION 0.294 0.268 False True IGHV1 IGKV6 Kappa None None None None None 8ukh I M 0 B protein NA cell traversal protein for ookinetes and sporozoites CELL INVASION 09/11/24 Crystal structure of Plasmodium falciparum CelTOS in complex with antibody 4h12 Mus musculus; Plasmodium falciparum 3D7 mus musculus mus musculus plasmodium falciparum 3d7 Tang, W.K., Tolia, N.H., Urusova, D. 3.52 X-RAY DIFFRACTION 0.294 0.268 False True IGHV1 IGKV6 Kappa None None None None None 8ukh J N 0 C protein NA cell traversal protein for ookinetes and sporozoites CELL INVASION 09/11/24 Crystal structure of Plasmodium falciparum CelTOS in complex with antibody 4h12 Mus musculus; Plasmodium falciparum 3D7 mus musculus mus musculus plasmodium falciparum 3d7 Tang, W.K., Tolia, N.H., Urusova, D. 3.52 X-RAY DIFFRACTION 0.294 0.268 False True IGHV1 IGKV6 Kappa None None None None None 8ukh K O 0 D protein NA cell traversal protein for ookinetes and sporozoites CELL INVASION 09/11/24 Crystal structure of Plasmodium falciparum CelTOS in complex with antibody 4h12 Mus musculus; Plasmodium falciparum 3D7 mus musculus mus musculus plasmodium falciparum 3d7 Tang, W.K., Tolia, N.H., Urusova, D. 3.52 X-RAY DIFFRACTION 0.294 0.268 False True IGHV1 IGKV6 Kappa None None None None None 8ulf H L 0 A protein NA pv cell-traversal protein CELL INVASION 09/11/24 Crystal structure of Plasmodium vivax CelTOS in complex with antibody 7g7 Mus musculus; Plasmodium vivax mus musculus mus musculus plasmodium vivax Tang, W.K., Tolia, N.H. 3.2 X-RAY DIFFRACTION 0.295 0.275 False True IGHV1 IGKV4 Kappa None None None None None 8ulf I M 0 B protein NA pv cell-traversal protein CELL INVASION 09/11/24 Crystal structure of Plasmodium vivax CelTOS in complex with antibody 7g7 Mus musculus; Plasmodium vivax mus musculus mus musculus plasmodium vivax Tang, W.K., Tolia, N.H. 3.2 X-RAY DIFFRACTION 0.295 0.275 False True IGHV1 IGKV4 Kappa None None None None None 8ulf J N 0 C protein NA pv cell-traversal protein CELL INVASION 09/11/24 Crystal structure of Plasmodium vivax CelTOS in complex with antibody 7g7 Mus musculus; Plasmodium vivax mus musculus mus musculus plasmodium vivax Tang, W.K., Tolia, N.H. 3.2 X-RAY DIFFRACTION 0.295 0.275 False True IGHV1 IGKV4 Kappa None None None None None 8ulf K O 0 D protein NA pv cell-traversal protein CELL INVASION 09/11/24 Crystal structure of Plasmodium vivax CelTOS in complex with antibody 7g7 Mus musculus; Plasmodium vivax mus musculus mus musculus plasmodium vivax Tang, W.K., Tolia, N.H. 3.2 X-RAY DIFFRACTION 0.295 0.275 False True IGHV1 IGKV4 Kappa None None None None None 8v8k A NA 0 NA NA NA NA IMMUNE SYSTEM 09/11/24 Crystal Structure of Nanobody NbE Lama glama lama glama Koehl, A., Manglik, A., Yu, J., Kumar, A., Zhang, X., Martin, C., Raia, P., Steyaert, J., Ballet, S., Boland, A., Stoeber, M. 2.85 X-RAY DIFFRACTION 0.331 0.286 False True IGHV1 NA NA None None None None None 8v8k B NA 0 NA NA NA NA IMMUNE SYSTEM 09/11/24 Crystal Structure of Nanobody NbE Lama glama lama glama Koehl, A., Manglik, A., Yu, J., Kumar, A., Zhang, X., Martin, C., Raia, P., Steyaert, J., Ballet, S., Boland, A., Stoeber, M. 2.85 X-RAY DIFFRACTION 0.331 0.286 False True IGHV1 NA NA None None None None None 8v8k C NA 0 NA NA NA NA IMMUNE SYSTEM 09/11/24 Crystal Structure of Nanobody NbE Lama glama lama glama Koehl, A., Manglik, A., Yu, J., Kumar, A., Zhang, X., Martin, C., Raia, P., Steyaert, J., Ballet, S., Boland, A., Stoeber, M. 2.85 X-RAY DIFFRACTION 0.331 0.286 False True IGHV1 NA NA None None None None None 8vuh H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE/IMMUNE SYSTEM 09/11/24 Human GluN1-2A IgG 003-102 splayed conformation Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 4.42 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vuh I M 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE/IMMUNE SYSTEM 09/11/24 Human GluN1-2A IgG 003-102 splayed conformation Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 4.42 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vuj H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with Fab 003-102 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.92 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vuj I M 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with Fab 003-102 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.92 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vul H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with Fab 003-102 Local refinement of ATD Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.83 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vun G I 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A With Fab 008-218 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 4.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8vun K L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A With Fab 008-218 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 4.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8vuq G I 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with Fab 008-218 Local refinement of ATD Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8vur H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with IgG 003-102 WT conformation Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vus E F 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with IgG 007-168 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.99 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8vus H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2A with IgG 007-168 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.99 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8vuu H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2B with Fab 007-168 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 4.05 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8vuu J K 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2B with Fab 007-168 Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 4.05 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8vuv H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Human GluN1-2B with Fab 007-168 Local refinement of ATD Homo sapiens homo sapiens homo sapiens homo sapiens Michalski, K., Furukawa, H. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8vuy H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 09/11/24 Rat GluN1-2B with Fab 003-102 Homo sapiens; Rattus norvegicus homo sapiens homo sapiens rattus norvegicus Michalski, K., Furukawa, H. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vuy J K 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 09/11/24 Rat GluN1-2B with Fab 003-102 Homo sapiens; Rattus norvegicus homo sapiens homo sapiens rattus norvegicus Michalski, K., Furukawa, H. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8vvh H L 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 09/11/24 rat GluN1a-2B Fab 003-102 local refinement Homo sapiens; Rattus norvegicus homo sapiens homo sapiens rattus norvegicus Michalski, K., Furukawa, H. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8w70 B A 0 NA NA NA NA IMMUNE SYSTEM 09/11/24 Structure of Gemtuzumab Fab Homo sapiens homo sapiens homo sapiens Heo, Y.S., Choi, S.B. 2.5 X-RAY DIFFRACTION 0.221 0.192 False True IGHV1 IGKV1 Kappa None None None None None 8y4a H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/11/24 BA.2.86 S-trimer in complex with Nab XG2v046 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, Q., Liu, P. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8y4a D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/11/24 BA.2.86 S-trimer in complex with Nab XG2v046 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, Q., Liu, P. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8ysf C NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/11/24 MERS-CoV RBD in complex with nanobody Nb9 Middle East respiratory syndrome-related coronavirus; Vicugna pacos vicugna pacos middle east respiratory syndrome-relatedcoronavirus Wang, Y.X., Ma, S. 2.76 X-RAY DIFFRACTION 0.270 0.233 False True IGHV1 NA NA None None None None None 8ysf D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/11/24 MERS-CoV RBD in complex with nanobody Nb9 Middle East respiratory syndrome-related coronavirus; Vicugna pacos vicugna pacos middle east respiratory syndrome-relatedcoronavirus Wang, Y.X., Ma, S. 2.76 X-RAY DIFFRACTION 0.270 0.233 False True IGHV1 NA NA None None None None None 8ysh A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/11/24 MERS-CoV RBD in complex with nanobody Nb14 Middle East respiratory syndrome-related coronavirus; Vicugna pacos vicugna pacos middle east respiratory syndrome-relatedcoronavirus Wang, Y.X., Ma, S. 1.99 X-RAY DIFFRACTION 0.239 0.229 False True IGHV1 NA NA None None None None None 8yxi C B 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/11/24 Crystal structure of SFTSV Gn in complex with a neutralizing antibody 40C10 Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Yang, P., Guo, Y., Zhang, N. 2.4 X-RAY DIFFRACTION 0.249 0.206 False False IGHV1 IGKV6 Kappa None None None None None 8zoy B NA 0 A protein NA sodium-dependent noradrenaline transporter TRANSPORT PROTEIN/IMMUNE SYSTEM 09/11/24 Cryo-EM structure of human norepinephrine transporter NET bound with norepinephrine in an inward open state at a resolution of 2.5 angstrom Homo sapiens; Lama glama lama glama homo sapiens Song, A.L., Wu, X.D. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8zpb B NA 0 A protein NA sodium-dependent noradrenaline transporter TRANSPORT PROTEIN/IMMUNE SYSTEM 09/11/24 Cryo-EM structure of human norepinephrine transporter NET bound with norepinephrine in an occluded state at a resolution of 2.6 angstrom Escherichia coli; Homo sapiens homo sapiens Song, A.L., Wu, X.D. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9clp H L 0 A protein NA zinc metalloproteinase-disintegrin-like ecarin HYDROLASE 09/11/24 Structure of ecarin from the venom of Kenyan saw-scaled viper in complex with the Fab of neutralizing antibody H11 Echis carinatus; Homo sapiens homo sapiens homo sapiens echis carinatus Mindrebo, J.T., Lander, G.C. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 9ima C D 0 A | B protein | protein NA | NA g-protein coupled receptor family c group 5 member d | g-protein coupled receptor family c group 5 member d MEMBRANE PROTEIN/IMMUNE SYSTEM 09/11/24 Cryo-EM structure for the GPRC5D complexed with Talquetamab Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Jeong, J., Shin, J., Park, J., Cho, Y. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9jbq A B 0 C protein NA pcrv ANTIMICROBIAL PROTEIN/IMMUNE SYSTEM 09/11/24 Structure of the complex between h1F3 Fab and PcrV fragment Homo sapiens; Pseudomonas aeruginosa homo sapiens homo sapiens pseudomonas aeruginosa Numata, S., Hara, T., Izawa, M., Okuno, Y., Sato, Y., Yamane, S., Maki, H., Sato, T., Yamano, Y. 2 X-RAY DIFFRACTION 0.216 0.169 False True IGHV1 IGKV1 Kappa None None None None None 8keh G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 State 2 of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8keh E D 0 A | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 State 2 of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8vr9 E D 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a alpha chain | gtpase kras, n-terminally processed IMMUNE SYSTEM 09/04/24 Structure of a synthetic antibody in complex with a class I MHC presenting a hapten-peptide conjugate Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Maso, L., Bang, I., Koide, S. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vra E D 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a alpha chain | gtpase kras, n-terminally processed IMMUNE SYSTEM 09/04/24 Structure of a synthetic antibody in complex with a class I MHC presenting a hapten-peptide conjugate Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Maso, L., Bang, I., Koide, S. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vrb E D 0 A | C protein | peptide NA | NA hla-a antigen | gtpase kras, n-terminally processed IMMUNE SYSTEM 09/04/24 Structure of a synthetic antibody in complex with a class I MHC presenting a hapten-peptide conjugate Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Maso, L., Bang, I., Koide, S. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8x9b O P 0 I | E protein | protein NA | NA genome polyprotein | capsid protein vp1 VIRAL PROTEIN 09/04/24 Cryo-EM structure of coxsackievirus A16 empty particle in complex with Fab h1A6.2 (local refinement) Coxsackievirus A16; Mus musculus mus musculus mus musculus coxsackievirus a16 | coxsackievirus a16 Jiang, Y., Huang, Y., Zhu, R., Zheng, Q., Li, S., Xia, N. 3.82 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV1 Kappa None None None None None 8x9b R S 0 L | H protein | protein NA | NA genome polyprotein | capsid protein vp1 VIRAL PROTEIN 09/04/24 Cryo-EM structure of coxsackievirus A16 empty particle in complex with Fab h1A6.2 (local refinement) Coxsackievirus A16; Mus musculus mus musculus mus musculus coxsackievirus a16 | coxsackievirus a16 Jiang, Y., Huang, Y., Zhu, R., Zheng, Q., Li, S., Xia, N. 3.82 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV1 Kappa None None None None None 8zer A NA 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the complex of Wuhan SARS-CoV-2 RBD (319-541) with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.1 X-RAY DIFFRACTION 0.283 0.222 False True IGHV1 NA NA None None None None None 8zer D NA 0 I protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the complex of Wuhan SARS-CoV-2 RBD (319-541) with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.1 X-RAY DIFFRACTION 0.283 0.222 False True IGHV1 NA NA None None None None None 8zer F NA 0 B | E protein | protein NA | NA spike protein s1 | spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the complex of Wuhan SARS-CoV-2 RBD (319-541) with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.1 X-RAY DIFFRACTION 0.283 0.222 False True IGHV1 NA NA None None None None None 8zer H NA 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the complex of Wuhan SARS-CoV-2 RBD (319-541) with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.1 X-RAY DIFFRACTION 0.283 0.222 False True IGHV1 NA NA None None None None None 8zer J NA 0 I protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the complex of Wuhan SARS-CoV-2 RBD (319-541) with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.1 X-RAY DIFFRACTION 0.283 0.222 False True IGHV1 NA NA None None None None None 8zes E NA 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the Wuhan SARS-CoV-2 RBD (333-541) complexed with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.7 X-RAY DIFFRACTION 0.269 0.207 False True IGHV1 NA NA None None None None None 8zes B NA 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the Wuhan SARS-CoV-2 RBD (333-541) complexed with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.7 X-RAY DIFFRACTION 0.269 0.207 False True IGHV1 NA NA None None None None None 8zes F NA 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the Wuhan SARS-CoV-2 RBD (333-541) complexed with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.7 X-RAY DIFFRACTION 0.269 0.207 False True IGHV1 NA NA None None None None None 8zes H NA 0 A | G protein | protein NA | NA spike protein s1 | spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the Wuhan SARS-CoV-2 RBD (333-541) complexed with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.7 X-RAY DIFFRACTION 0.269 0.207 False True IGHV1 NA NA None None None None None 8zes J NA 0 I protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 Crystal structure of the Wuhan SARS-CoV-2 RBD (333-541) complexed with P2C5 nanobody Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sluchanko, N.N., Varfolomeeva, L.A., Shcheblyakov, D.V., Logunov, D.Y., Gintsburg, A.L., Popov, V.O., Boyko, K.M. 3.7 X-RAY DIFFRACTION 0.269 0.207 False True IGHV1 NA NA None None None None None 8jxr H L 0 C protein NA maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g MEMBRANE PROTEIN 09/04/24 Structure of nanobody-bound DRD1_LSD complex Escherichia coli O157:H7; Homo sapiens; Mus musculus; Staphylococcus aureus; Staphylococcus aureus subsp. aureus Mu50; Streptococcus sp. 'group G' mus musculus mus musculus escherichia coli o157aureus, staphylococcus aureus subsp. aureus mu50, streptococcus sp. 'group g' Zhuang, Y., Xu, Y., Fan, L., Wang, S., Xu, H.E. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 8jxr B NA 0 A protein NA d(1a) dopamine receptor MEMBRANE PROTEIN 09/04/24 Structure of nanobody-bound DRD1_LSD complex Escherichia coli O157:H7; Homo sapiens; Mus musculus; Staphylococcus aureus; Staphylococcus aureus subsp. aureus Mu50; Streptococcus sp. 'group G' homo sapiens homo sapiens Zhuang, Y., Xu, Y., Fan, L., Wang, S., Xu, H.E. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jxs H L 0 C protein NA maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g MEMBRANE PROTEIN 09/04/24 Structure of nanobody-bound DRD1_PF-6142 complex Escherichia coli K-12; Homo sapiens; Mus musculus; Staphylococcus aureus mus musculus mus musculus escherichia coli k-12, staphylococcus aureus Zhuang, Y., Xu, Y., Fan, L., Wang, S., Xu, H.E. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 8jxs B NA 0 A protein NA d(1a) dopamine receptor MEMBRANE PROTEIN 09/04/24 Structure of nanobody-bound DRD1_PF-6142 complex Escherichia coli K-12; Homo sapiens; Mus musculus; Staphylococcus aureus homo sapiens homo sapiens Zhuang, Y., Xu, Y., Fan, L., Wang, S., Xu, H.E. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8qw4 B NA 0 A protein NA frizzled-3 CELL ADHESION 09/04/24 FZD3 in complex with nanobody 9 Homo sapiens; Lama glama lama glama homo sapiens Zhao, Y., Jones, E.Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rvn H L 0 F protein NA fusion glycoprotein f0 VIRAL PROTEIN 09/04/24 Nipah virus (NiV) fusion protein in complex with neutralizing Fab92 Henipavirus nipahense; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus henipavirus nipahense Avanzato, V.A., Stass, R., Duyvesteyn, H.M.E., Bowden, T.A. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8sow C c 0 A protein NA interleukin-2 CYTOKINE 09/04/24 Structure of the complex formed by human interleukin-2 and scFv F10 Homo sapiens homo sapiens homo sapiens Gould, J.R., Leonard, E.K., Cao, S.D., Spangler, J.B. 1.71 X-RAY DIFFRACTION 0.235 0.216 True True unknown unknown unknown None None None None None 8soz C c 0 A protein NA interleukin-2 CYTOKINE 09/04/24 Structure of the complex formed by human interleukin-2 and scFv 602 Homo sapiens homo sapiens homo sapiens Gould, J.R., Leonard, E.K., Cao, S.D., Spangler, J.B. 1.64 X-RAY DIFFRACTION 0.250 0.219 True True unknown unknown unknown None None None None None 8tzy A B 0 C protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 CryoEM structure of non-neutralizing bivalent antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 Hepatitis C virus (isolate 1); Homo sapiens homo sapiens homo sapiens hepatitis c virus (isolate 1) Shahid, S., Liqun, J., Liu, Y., Hasan, S.S., Mariuzza, R.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8tzy D E 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 CryoEM structure of non-neutralizing bivalent antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 Hepatitis C virus (isolate 1); Homo sapiens homo sapiens homo sapiens Shahid, S., Liqun, J., Liu, Y., Hasan, S.S., Mariuzza, R.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8u3s B NA 0 A protein NA tudor-interacting repair regulator protein RNA BINDING PROTEIN 09/04/24 Structure of human TIRR in complex with VHH4 nanobody Homo sapiens; Lama glama lama glama homo sapiens Botuyan, M.V., Mer, G. 1.85 X-RAY DIFFRACTION 0.271 0.214 False True IGHV3 NA NA None None None None None 8uvy B NA 0 A protein NA rac-alpha serine/threonine-protein kinase TRANSFERASE/INHIBITOR 09/04/24 Structure of AKT1(E17K) with compound 3 Homo sapiens; Lama glama lama glama homo sapiens Craven, G.B., Taunton, J. 2.11 X-RAY DIFFRACTION 0.255 0.206 False True IGHV1 NA NA None None None None None 8uw2 B NA 0 A protein NA rac-alpha serine/threonine-protein kinase TRANSFERASE/INHIBITOR 09/04/24 Structure of AKT1(E17K) with compound 3 (zinc-free) Homo sapiens; Lama glama lama glama homo sapiens Craven, G.B., Taunton, J. 2.2 X-RAY DIFFRACTION 0.279 0.220 False True IGHV1 NA NA None None None None None 8uw7 B NA 0 A protein NA rac-alpha serine/threonine-protein kinase TRANSFERASE/INHIBITOR 09/04/24 Structure of AKT1(WT) with compound 3 Homo sapiens; Lama glama lama glama homo sapiens Craven, G.B., Taunton, J. 1.972 X-RAY DIFFRACTION 0.265 0.218 False True IGHV1 NA NA None None None None None 8uw9 B NA 0 A protein NA rac-alpha serine/threonine-protein kinase TRANSFERASE/INHIBITOR 09/04/24 Structure of AKT1(E17K) with compound 4 Homo sapiens; Lama glama lama glama homo sapiens Craven, G.B., Taunton, J. 1.9 X-RAY DIFFRACTION 0.245 0.205 False True IGHV1 NA NA None None None None None 8v4i H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE1 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 1.81 X-RAY DIFFRACTION 0.257 0.221 False True IGHV1 IGLV1 Lambda None None None None None 8vbj H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE2 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.231 0.192 False True unknown IGLV1 Lambda None None None None None 8vbk H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE5 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 1.89 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 IGLV1 Lambda None None None None None 8vbl H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE6 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.35 X-RAY DIFFRACTION 0.245 0.198 False True IGHV1 IGLV1 Lambda None None None None None 8vbm H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE7 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.54 X-RAY DIFFRACTION 0.290 0.235 False True IGHV1 IGLV1 Lambda None None None None None 8vbn H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE8 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 1.83 X-RAY DIFFRACTION 0.218 0.196 False True IGHV1 IGLV1 Lambda None None None None None 8vbn B A 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE8 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 1.83 X-RAY DIFFRACTION 0.218 0.196 False True IGHV1 IGLV1 Lambda None None None None None 8vbo H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE9 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.281 0.248 False True IGHV1 IGLV1 Lambda None None None None None 8vbp H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab Bess4 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.232 0.197 False True IGHV1 IGLV1 Lambda None None None None None 8vbq H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab Bess7 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.268 0.232 False True IGHV1 IGLV1 Lambda None None None None None 8vbr H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE11 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.65 X-RAY DIFFRACTION 0.260 0.247 False True IGHV1 IGLV1 Lambda None None None None None 8vbr B A 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Structure of bovine anti-HIV Fab ElsE11 Bos taurus bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.65 X-RAY DIFFRACTION 0.260 0.247 False True IGHV1 IGLV1 Lambda None None None None None 8w90 A NA 0 B protein NA t-cell surface glycoprotein cd4 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 crystal structure of CD4-D1D2 with Nb457 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Wang, X.Y., Wang, Y.X. 1.81 X-RAY DIFFRACTION 0.206 0.186 False True IGHV1 NA NA None None None None None 8w90 C NA 0 D protein NA t-cell surface glycoprotein cd4 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 crystal structure of CD4-D1D2 with Nb457 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Wang, X.Y., Wang, Y.X. 1.81 X-RAY DIFFRACTION 0.206 0.186 False True IGHV1 NA NA None None None None None 8w90 E NA 0 F protein NA t-cell surface glycoprotein cd4 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 crystal structure of CD4-D1D2 with Nb457 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Wang, X.Y., Wang, Y.X. 1.81 X-RAY DIFFRACTION 0.206 0.186 False True IGHV1 NA NA None None None None None 8y4c H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 BA.2.86 S-trimer in complex with Nab XGv280 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, Q., Liu, P. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8y4c D F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 BA.2.86 S-trimer in complex with Nab XGv280 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, Q., Liu, P. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8y4c E G 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/04/24 BA.2.86 S-trimer in complex with Nab XGv280 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, Q., Liu, P. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8z8m B NA 0 A protein NA tumor necrosis factor CYTOKINE 09/04/24 Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab Homo sapiens homo sapiens homo sapiens Mima, M., Mishima-Tsumagari, C. 2.59 X-RAY DIFFRACTION 0.269 0.209 False True IGHV3 NA NA None None None None None 8z8m D NA 0 C protein NA tumor necrosis factor CYTOKINE 09/04/24 Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab Homo sapiens homo sapiens homo sapiens Mima, M., Mishima-Tsumagari, C. 2.59 X-RAY DIFFRACTION 0.269 0.209 False True IGHV3 NA NA None None None None None 8z8m F NA 0 E protein NA tumor necrosis factor CYTOKINE 09/04/24 Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab Homo sapiens homo sapiens homo sapiens Mima, M., Mishima-Tsumagari, C. 2.59 X-RAY DIFFRACTION 0.269 0.209 False True IGHV3 NA NA None None None None None 8z8m H NA 0 G protein NA tumor necrosis factor CYTOKINE 09/04/24 Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab Homo sapiens homo sapiens homo sapiens Mima, M., Mishima-Tsumagari, C. 2.59 X-RAY DIFFRACTION 0.269 0.209 False True IGHV3 NA NA None None None None None 8z8m J NA 0 I protein NA tumor necrosis factor CYTOKINE 09/04/24 Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab Homo sapiens homo sapiens homo sapiens Mima, M., Mishima-Tsumagari, C. 2.59 X-RAY DIFFRACTION 0.269 0.209 False True IGHV3 NA NA None None None None None 8z8m L NA 0 K protein NA tumor necrosis factor CYTOKINE 09/04/24 Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab Homo sapiens homo sapiens homo sapiens Mima, M., Mishima-Tsumagari, C. 2.59 X-RAY DIFFRACTION 0.269 0.209 False True IGHV3 NA NA None None None None None 8z8v B NA 0 A protein NA serum albumin TRANSPORT PROTEIN 09/04/24 Crystal structure of human serum albumin in complex with ALB8(VHH) domain of ozoralizumab Homo sapiens homo sapiens homo sapiens Mima, M., Mishima-Tsumagari, C. 2.05 X-RAY DIFFRACTION 0.239 0.202 False True IGHV3 NA NA None None None None None 9aur H L 0 R nucleic-acid NA loop-closed a21 2'-ome dumbbell rna bridged by glycine RNA 09/04/24 Crystal structure of loop-closed A21 2'-OMe dumbbell RNA bridged by glycine Mus musculus mus musculus mus musculus mus musculus Radakovic, A., Lewicka, A., Todisco, M., Aitken, H.R.M., Weiss, Z., Kim, S., Bannan, A., Piccirilli, J.A., Szostak, J.W. 1.57 X-RAY DIFFRACTION 0.212 0.186 False True IGHV3 IGKV1 Kappa None None None None None 9aus H L 0 R nucleic-acid NA loop-closed dumbbell rna bridged by glycine RNA 09/04/24 Crystal structure of loop-closed dumbbell RNA bridged by glycine Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus unidentified Radakovic, A., Lewicka, A., Todisco, M., Aitken, H.R.M., Weiss, Z., Kim, S., Bannan, A., Piccirilli, J.A., Szostak, J.W. 2.07 X-RAY DIFFRACTION 0.254 0.221 False True IGHV3 IGKV1 Kappa None None None None None 9aus A B 0 C nucleic-acid NA loop-closed dumbbell rna bridged by glycine RNA 09/04/24 Crystal structure of loop-closed dumbbell RNA bridged by glycine Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus unidentified Radakovic, A., Lewicka, A., Todisco, M., Aitken, H.R.M., Weiss, Z., Kim, S., Bannan, A., Piccirilli, J.A., Szostak, J.W. 2.07 X-RAY DIFFRACTION 0.254 0.221 False True IGHV3 IGKV1 Kappa None None None None None 9b44 A B 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Crystal structure of mAb 8-24 Fab, a VRC01-like HIV-1 antibody Mus musculus mus musculus mus musculus Kher, G., Hurlburt, N., Pancera, M. 2.01 X-RAY DIFFRACTION 0.281 0.227 False True IGHV1 IGKV8 Kappa None None None None None 9b44 H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 Crystal structure of mAb 8-24 Fab, a VRC01-like HIV-1 antibody Mus musculus mus musculus mus musculus Kher, G., Hurlburt, N., Pancera, M. 2.01 X-RAY DIFFRACTION 0.281 0.227 False True IGHV1 IGKV8 Kappa None None None None None 9bge D E 0 B protein NA 426c.wito.tm.sosip IMMUNE SYSTEM 09/04/24 Cryo-EM structure of mAb8-24 bound to 426c.WITO.TM.SOSIP Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Hurlburt, N.K., Pancera, M. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9bge F G 0 C protein NA 426c.wito.tm.sosip IMMUNE SYSTEM 09/04/24 Cryo-EM structure of mAb8-24 bound to 426c.WITO.TM.SOSIP Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Hurlburt, N.K., Pancera, M. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9bge H L 0 A protein NA 426c.wito.tm.sosip IMMUNE SYSTEM 09/04/24 Cryo-EM structure of mAb8-24 bound to 426c.WITO.TM.SOSIP Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Hurlburt, N.K., Pancera, M. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 9iy0 H L 0 NA NA NA NA IMMUNE SYSTEM 09/04/24 anti-HEV mAb 8H3 Mus sp. mus sp. mus sp. Minghua, Z., Lizhi, Z., Yang, H., Ying, G., Shaowei, L. 1.97 X-RAY DIFFRACTION 0.231 0.192 False False IGHV2 IGKV8 Kappa None None None None None 8tkc G H 0 B | A protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tkc I J 0 D | C protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tkc K L 0 F | E protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl2 G H 0 B | A protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl2 K L 0 F | D | E protein | protein | protein NA | NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl3 G H 0 B | A protein | protein NA | NA bg505 ds-sosip glycoprotein gp41 | bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl3 I J 0 D | C protein | protein NA | NA bg505 ds-sosip glycoprotein gp41 | bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl3 K L 0 F | E protein | protein NA | NA bg505 ds-sosip glycoprotein gp41 | bg505 ds-sosip glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl4 G H 0 B | A protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-e.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl4 I J 0 D | C protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-e.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl4 K L 0 F | E protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-e.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tl5 G H 0 B | A protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tl5 I J 0 D | C protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tl5 K L 0 F | E protein | protein NA | NA bg505 ds-sosip transmembrane protein gp41 | bg505 ds-sosip surface protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Hoyt, F., Fischer, E., Kwong, P. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8q6r A NA 0 D protein NA properdin IMMUNE SYSTEM 08/28/24 Structure of complement FP in complex with the TPP-3077 VHH Homo sapiens; Lama glama lama glama homo sapiens Andersen, G.R., Pedersen, D.V. 1.9 X-RAY DIFFRACTION 0.238 0.202 False True IGHV3 NA NA None None None None None 8q6r B NA 0 F protein NA properdin IMMUNE SYSTEM 08/28/24 Structure of complement FP in complex with the TPP-3077 VHH Homo sapiens; Lama glama lama glama homo sapiens Andersen, G.R., Pedersen, D.V. 1.9 X-RAY DIFFRACTION 0.238 0.202 False True IGHV3 NA NA None None None None None 8q7o A NA 0 C protein NA frizzled-3 SIGNALING PROTEIN 08/28/24 Crystal structure of the FZD3 cysteine-rich domain in complex with a nanobody (14478) Homo sapiens; Lama glama lama glama homo sapiens Hillier, J.S., Zhao, Y., Malinauskas, T., Jones, E.Y. 1.76 X-RAY DIFFRACTION 0.222 0.217 False True IGHV1 NA NA None None None None None 8q7o B NA 0 D protein NA frizzled-3 SIGNALING PROTEIN 08/28/24 Crystal structure of the FZD3 cysteine-rich domain in complex with a nanobody (14478) Homo sapiens; Lama glama lama glama homo sapiens Hillier, J.S., Zhao, Y., Malinauskas, T., Jones, E.Y. 1.76 X-RAY DIFFRACTION 0.222 0.217 False True IGHV1 NA NA None None None None None 8tbb H L 0 D protein NA t-cell immunoglobulin mucin receptor 3 IMMUNE SYSTEM 08/28/24 F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3 Homo sapiens homo sapiens homo sapiens homo sapiens Oganesyan, V., van Dyk, N., Mazor, Y., Yang, C. 2.5 X-RAY DIFFRACTION 0.241 0.191 False True IGHV3 IGKV1 Kappa None None None None None 8tft I M 0 F protein NA t-cell immunoglobulin mucin receptor 3 IMMUNE SYSTEM 08/28/24 Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 Homo sapiens homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., van Dyk, N., Mazor, Y., Yang, C. 2.3 X-RAY DIFFRACTION 0.271 0.244 False True IGHV3 IGLV3 Lambda None None None None None 8tft H L 0 G protein NA t-cell immunoglobulin mucin receptor 3 IMMUNE SYSTEM 08/28/24 Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 Homo sapiens homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., van Dyk, N., Mazor, Y., Yang, C. 2.3 X-RAY DIFFRACTION 0.271 0.244 False True IGHV3 IGLV3 Lambda None None None None None 8tuz H L 0 A protein NA outer surface protein a IMMUNE SYSTEM 08/28/24 Fab 857-2 in complex with OspA Borreliella burgdorferi; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi Rudolph, M.J., Mantis, N. 2.186 X-RAY DIFFRACTION 0.239 0.177 False True IGHV5 IGKV1 Kappa None None None None None 8tv3 H L 0 A protein NA outer surface protein a IMMUNE SYSTEM 08/28/24 Fab 221-5 in complex with OspA Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 2.312 X-RAY DIFFRACTION 0.227 0.199 False True IGHV5 IGKV3 Kappa None None None None None 8tvd H L 0 E protein NA outer surface protein a IMMUNE SYSTEM/Membrane Protein 08/28/24 Fab 221-11 in complex with OspA Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.077 X-RAY DIFFRACTION 0.286 0.234 False True IGHV5 IGKV1 Kappa None None None None None 8tvd B A 0 C protein NA outer surface protein a IMMUNE SYSTEM/Membrane Protein 08/28/24 Fab 221-11 in complex with OspA Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.077 X-RAY DIFFRACTION 0.286 0.234 False True IGHV5 IGKV1 Kappa None None None None None 8tvj H L 0 E protein NA outer surface protein a IMMUNE SYSTEM/Membrane Protein 08/28/24 Fab 227-1 in complex with OspA Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 3.168 X-RAY DIFFRACTION 0.295 0.235 False True IGHV5 IGKV1 Kappa None None None None None 8ug9 M NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 XBB.1.5 spike/Nb5 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ug9 N NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 XBB.1.5 spike/Nb5 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ug9 O NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/28/24 XBB.1.5 spike/Nb5 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8xve N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/28/24 Cryo-EM structure of ETBR bound with BQ3020 Clostridium perfringens; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Hou, J.Y., Liu, S.H., Wu, L.J., Liu, Z.J., Hua, T. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xvh N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/28/24 Cryo-EM structure of ETBR bound with Endothelin1 Clostridium perfringens; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Hou, J.Y., Liu, S.H., Wu, L.J., Liu, Z.J., Hua, T. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xvi N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/28/24 Cryo-EM structure of ETAR bound with Endothelin1 Acetivibrio thermocellus ATCC 27405; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Hou, J.Y., Liu, S.H., Wu, L.J., Liu, Z.J., Hua, T. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9iy2 H L 0 A protein NA secreted protein orf2 IMMUNE SYSTEM 08/28/24 Immune complex of HEV-E2s, nAb 8C11 and nAb 8H3 Hepatitis E virus (strain Pakistan); Mus sp. mus sp. mus sp. hepatitis e virus (strain pakistan) Minghua, Z., Lizhi, Z., Ying, G., Shaowei, L. 3.476 X-RAY DIFFRACTION 0.269 0.223 False False IGHV8 IGKV12 Kappa None None None None None 9iy2 D C 0 B protein NA secreted protein orf2 IMMUNE SYSTEM 08/28/24 Immune complex of HEV-E2s, nAb 8C11 and nAb 8H3 Hepatitis E virus (strain Pakistan); Mus sp. mus sp. mus sp. hepatitis e virus (strain pakistan) Minghua, Z., Lizhi, Z., Ying, G., Shaowei, L. 3.476 X-RAY DIFFRACTION 0.269 0.223 False False IGHV8 IGKV12 Kappa None None None None None 9iy2 E F 0 B protein NA secreted protein orf2 IMMUNE SYSTEM 08/28/24 Immune complex of HEV-E2s, nAb 8C11 and nAb 8H3 Hepatitis E virus (strain Pakistan); Mus sp. mus sp. mus sp. hepatitis e virus (strain pakistan) Minghua, Z., Lizhi, Z., Ying, G., Shaowei, L. 3.476 X-RAY DIFFRACTION 0.269 0.223 False False IGHV2 IGKV8 Kappa None None None None None 9iy2 G I 0 A protein NA secreted protein orf2 IMMUNE SYSTEM 08/28/24 Immune complex of HEV-E2s, nAb 8C11 and nAb 8H3 Hepatitis E virus (strain Pakistan); Mus sp. mus sp. mus sp. hepatitis e virus (strain pakistan) Minghua, Z., Lizhi, Z., Ying, G., Shaowei, L. 3.476 X-RAY DIFFRACTION 0.269 0.223 False False IGHV2 IGKV8 Kappa None None None None None 9ijd D d 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN/IMMUNE SYSTEM 08/21/24 Carazolol-activated human beta3 adrenergic receptor Bos taurus; Homo sapiens; Lama glama; Rattus norvegicus homo sapiens bos taurus Zheng, S., Zhang, S., Dai, S., Chen, K., Gao, K., Lin, B., Liu, X. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ijd N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/21/24 Carazolol-activated human beta3 adrenergic receptor Bos taurus; Homo sapiens; Lama glama; Rattus norvegicus lama glama bos taurus | rattus norvegicus Zheng, S., Zhang, S., Dai, S., Chen, K., Gao, K., Lin, B., Liu, X. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9ije D d 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN/IMMUNE SYSTEM 08/21/24 Epinephrine-activated human beta3 adrenergic receptor Bos taurus; Homo sapiens; Lama glama; Rattus norvegicus homo sapiens bos taurus Zheng, S., Zhang, S., Dai, S., Chen, K., Gao, K., Lin, B., Liu, X. 2.34 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9ije N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/21/24 Epinephrine-activated human beta3 adrenergic receptor Bos taurus; Homo sapiens; Lama glama; Rattus norvegicus lama glama bos taurus | rattus norvegicus Zheng, S., Zhang, S., Dai, S., Chen, K., Gao, K., Lin, B., Liu, X. 2.34 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jjp S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/21/24 G protein-coupled receptor 1 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Liu, A., Liu, Y., Chen, G., Ye, F. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8tzq E e 0 B | A protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/21/24 CryoEM structure of D2 dopamine receptor in complex with GoA KE Mutant, scFv16, and dopamine Escherichia coli; Homo sapiens homo sapiens | homo sapiens Krumm, B.E., Kapolka, N.J., Fay, J.F., Roth, B.L. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xgm S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/21/24 Cryo-EM structure of human GPR1 bound to chemerin Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Liu, A.J., Liu, Y.Z., Ye, R.D. 3.29 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zhe H L 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three R1-26 Fabs Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhe F G 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three R1-26 Fabs Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhe J K 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three R1-26 Fabs Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhf H L 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 5.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhf F G 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 5.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhf J K 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 5.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhf R U 0 D protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 5.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhf M N 0 I protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 5.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhf S T 0 E protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 5.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhg H L 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, focused refinement of RBD-Fab region Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8zhk E D 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 6.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhk J F 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 6.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhk M K 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 6.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhk N L 0 I protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 6.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhk P O 0 H protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 6.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhk R Q 0 G protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 6.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhn G I 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zhn E D 0 C protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhn H L 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zhn N O 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zhn J F 0 B protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhn M K 0 A protein NA spike glycoprotein,fibritin,expression tag VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) Enterobacteria phage T6; Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t6, synthetic construct Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zho D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 S1 in complex with H18 and R1-32 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zho H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 SARS-CoV-2 S1 in complex with H18 and R1-32 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhp D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 Dimer of SARS-CoV-2 S1 in complex with H18 and R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zhp H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 Dimer of SARS-CoV-2 S1 in complex with H18 and R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8zhp B F 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 Dimer of SARS-CoV-2 S1 in complex with H18 and R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zhp G I 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/21/24 Dimer of SARS-CoV-2 S1 in complex with H18 and R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, Q., Gao, X., Liu, B., Hou, R., He, P., Li, Z., Chen, Q., Wang, J., He, J., Chen, L., Zhao, J., Xiong, X. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8kdm E D 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 Structure of SARS-CoV Spike protein complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8kdm G F 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 Structure of SARS-CoV Spike protein complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8q3j C B 0 A protein NA interleukin-1 family member 10 CYTOKINE 08/14/24 Crystal structure of mIL-38 in complex with a neutralizing Fab e04 fragment Mus musculus mus musculus mus musculus mus musculus Garcia-Pardo, J., Da Silva, P., Mora, J., Wiechmann, S., Putyrski, M., You, X., Kannt, A., Ernst, A., Brune, B., Weigert, A. 2.5 X-RAY DIFFRACTION 0.283 0.227 False True IGHV3 IGKV1 Kappa None None None None None 8q3j F E 0 D protein NA interleukin-1 family member 10 CYTOKINE 08/14/24 Crystal structure of mIL-38 in complex with a neutralizing Fab e04 fragment Mus musculus mus musculus mus musculus mus musculus Garcia-Pardo, J., Da Silva, P., Mora, J., Wiechmann, S., Putyrski, M., You, X., Kannt, A., Ernst, A., Brune, B., Weigert, A. 2.5 X-RAY DIFFRACTION 0.283 0.227 False True IGHV3 IGKV1 Kappa None None None None None 8kdr H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 The local refined map of SARS-CoV-2 XBB Variant Spike protein complexed with antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8kds E D 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Trimer state of SARS-CoV Spike protein complexed with antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8kds G F 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Trimer state of SARS-CoV Spike protein complexed with antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8kds I H 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Trimer state of SARS-CoV Spike protein complexed with antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8kdt H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 The local refined map of SARS-CoV Spike protein complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8kej H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Monomer state of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8kek H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Monomer state of SARS-CoV Spike protein complexed with antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8keo E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 Structure of SARS-CoV-2 Omicron BA.1 Spike complexed with antibody PW5-570 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8keo G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 Structure of SARS-CoV-2 Omicron BA.1 Spike complexed with antibody PW5-570 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8keo I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 Structure of SARS-CoV-2 Omicron BA.1 Spike complexed with antibody PW5-570 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8kep H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 The local refined map of SARS-CoV-2 Omicron BA.1 Spike complexed with antibody PW5-570 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8keq E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 State 1 of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8keq G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/14/24 State 1 of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ker I H 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Structure of SARS-CoV-2 XBB Variant Spike protein complexed with broadly neutralizing antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ker E D 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Structure of SARS-CoV-2 XBB Variant Spike protein complexed with broadly neutralizing antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ker G F 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/14/24 Structure of SARS-CoV-2 XBB Variant Spike protein complexed with broadly neutralizing antibody PW5-535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, L., Mao, Q., Wang, Y. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tnj D C 0 A protein NA 9mer peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 08/14/24 Cryo-EM structure of HLA-B*73:01 bound to a 9mer peptide and two Fabs Homo sapiens homo sapiens homo sapiens homo sapiens Ross, P., Adams, E.J., Lodwick, J., Zhao, M., Slezak, T., Kossiakoff, A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tnj E F 0 A protein NA 9mer peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 08/14/24 Cryo-EM structure of HLA-B*73:01 bound to a 9mer peptide and two Fabs Homo sapiens homo sapiens homo sapiens homo sapiens Ross, P., Adams, E.J., Lodwick, J., Zhao, M., Slezak, T., Kossiakoff, A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8u5l F f 0 D protein NA capsid protein vp1 Viral Protein/Immune System 08/14/24 MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK virus VP1 Betapolyomavirus hominis; Homo sapiens homo sapiens betapolyomavirus hominis Knapp, M.S., Ornelas, E. 2.7 X-RAY DIFFRACTION 0.217 0.183 True True unknown unknown unknown None None None None None 8u5l H h 0 C protein NA capsid protein vp1 Viral Protein/Immune System 08/14/24 MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK virus VP1 Betapolyomavirus hominis; Homo sapiens homo sapiens betapolyomavirus hominis Knapp, M.S., Ornelas, E. 2.7 X-RAY DIFFRACTION 0.217 0.183 True True unknown unknown unknown None None None None None 8u5l J j 0 A protein NA capsid protein vp1 Viral Protein/Immune System 08/14/24 MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK virus VP1 Betapolyomavirus hominis; Homo sapiens homo sapiens betapolyomavirus hominis Knapp, M.S., Ornelas, E. 2.7 X-RAY DIFFRACTION 0.217 0.183 True True unknown unknown unknown None None None None None 8u5l K k 0 E protein NA capsid protein vp1 Viral Protein/Immune System 08/14/24 MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK virus VP1 Betapolyomavirus hominis; Homo sapiens homo sapiens betapolyomavirus hominis Knapp, M.S., Ornelas, E. 2.7 X-RAY DIFFRACTION 0.217 0.183 True True unknown unknown unknown None None None None None 8u5l N n 0 B protein NA capsid protein vp1 Viral Protein/Immune System 08/14/24 MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK virus VP1 Betapolyomavirus hominis; Homo sapiens homo sapiens betapolyomavirus hominis Knapp, M.S., Ornelas, E. 2.7 X-RAY DIFFRACTION 0.217 0.183 True True unknown unknown unknown None None None None None 8vy4 A B 0 C peptide NA pca-asp-gly-asn-glu-glu-met IMMUNE SYSTEM 07/24/24 Engineering a Tumor-Selective Prodrug T Cell Engager Bispecific Antibody for Safer Immunotherapy Homo sapiens; Mus musculus mus musculus homo sapiens homo sapiens Antonysamy, S., Demarest, S., Froning, K., Hickey, M.H., Kuhlman, B., McCue, A.C. 1.7 X-RAY DIFFRACTION 0.228 0.179 False True IGHV1 IGKV1 Kappa None None None None None 8sdh H L 0 B protein NA spike protein s1 IMMUNE SYSTEM 08/07/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.56 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.84 X-RAY DIFFRACTION 0.283 0.246 False True IGHV5 IGLV3 Lambda None None None None None 8sdh C D 0 A protein NA spike protein s1 IMMUNE SYSTEM 08/07/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.56 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.84 X-RAY DIFFRACTION 0.283 0.246 False True IGHV5 IGLV3 Lambda None None None None None 8to9 D F 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of TRNM-f*01 Fab in complex with HIV-1 Env trimer ConC SOSIP Homo sapiens; Macaca mulatta macaca mulatta macaca mulatta homo sapiens Roark, R.S., Morano, N.C., Shapiro, L.S., Kwong, P.D. 4.03 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8to9 E G 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of TRNM-f*01 Fab in complex with HIV-1 Env trimer ConC SOSIP Homo sapiens; Macaca mulatta macaca mulatta macaca mulatta homo sapiens Roark, R.S., Morano, N.C., Shapiro, L.S., Kwong, P.D. 4.03 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8to9 H L 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/07/24 Cryo-EM structure of TRNM-f*01 Fab in complex with HIV-1 Env trimer ConC SOSIP Homo sapiens; Macaca mulatta macaca mulatta macaca mulatta homo sapiens Roark, R.S., Morano, N.C., Shapiro, L.S., Kwong, P.D. 4.03 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tpw H L 0 B | A protein | protein NA | NA eryaii,eryaii,eryaii,eryaii,6-deoxyerythronolide-b synthaseerya3, modules 5 and 6 | eryaii,eryaii,eryaii,eryaii,6-deoxyerythronolide-b synthaseerya3, modules 5 and 6 BIOSYNTHETIC PROTEIN 08/07/24 Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea | saccharopolyspora erythraea Cogan, D.P., Soohoo, A.M., Chen, M., Brodsky, K.L., Liu, Y., Khosla, C. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8tpx H L 0 B | A protein | protein NA | NA eryaii,eryaii,eryaii,6-deoxyerythronolide-b synthase erya3,modules 5 and 6 | eryaii,eryaii,eryaii,6-deoxyerythronolide-b synthase erya3,modules 5 and 6 BIOSYNTHETIC PROTEIN 08/07/24 Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea | saccharopolyspora erythraea Cogan, D.P., Soohoo, A.M., Chen, M., Brodsky, K.L., Liu, Y., Khosla, C. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8v9w A NA 0 A Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 complexed with fentanyl Camelidae camelidae camelidae Moller, N., Shi, K., Aihara, H. 1.68 X-RAY DIFFRACTION 0.240 0.198 False True IGHV1 NA NA None None None None None 8v9w B NA 0 B Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 complexed with fentanyl Camelidae camelidae camelidae Moller, N., Shi, K., Aihara, H. 1.68 X-RAY DIFFRACTION 0.240 0.198 False True IGHV1 NA NA None None None None None 8v9w C NA 0 C Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 complexed with fentanyl Camelidae camelidae camelidae Moller, N., Shi, K., Aihara, H. 1.68 X-RAY DIFFRACTION 0.240 0.198 False True IGHV1 NA NA None None None None None 8v9w D NA 0 D Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 complexed with fentanyl Camelidae camelidae camelidae Moller, N., Shi, K., Aihara, H. 1.68 X-RAY DIFFRACTION 0.240 0.198 False True IGHV1 NA NA None None None None None 8v9x A NA 0 A Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 complex with fentanyl Camelidae camelidae camelidae Moller, N., Shi, K., Aihara, H. 1.55 X-RAY DIFFRACTION 0.218 0.187 False True IGHV1 NA NA None None None None None 8v9y A NA 0 NA NA NA NA ANTITOXIN 08/07/24 X-ray crystal structure of nanobody JGFN4 Camelidae camelidae Shi, K., Moller, N., Aihara, H. 1.76 X-RAY DIFFRACTION 0.232 0.191 False True IGHV1 NA NA None None None None None 8v9z A NA 0 A Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 N76D complexed with fentanyl in monomer form Camelidae camelidae camelidae Shi, K., Moller, N., Aihara, H. 1.6 X-RAY DIFFRACTION 0.267 0.234 False True IGHV1 NA NA None None None None None 8va0 A NA 0 A Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 N76D complexed with fentanyl in dimer form Camelidae camelidae camelidae Shi, K., Moller, N., Aihara, H. 1.85 X-RAY DIFFRACTION 0.240 0.203 False True IGHV1 NA NA None None None None None 8va0 B NA 0 B Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide ANTITOXIN 08/07/24 X-ray crystal structure of JGFN4 N76D complexed with fentanyl in dimer form Camelidae camelidae camelidae Shi, K., Moller, N., Aihara, H. 1.85 X-RAY DIFFRACTION 0.240 0.203 False True IGHV1 NA NA None None None None None 8yw5 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/07/24 Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Li, W.Z., Zhou, Q.T., Cong, Z.T., Yuan, Q.N., Li, W.X., Zhao, F.H., Xu, H.E., Zhao, L.H., Yang, D.H., Wang, M.W. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zfj D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/07/24 cryo-EM structure of GPR4-Gs complex at pH 8.5 Danio rerio; Escherichia coli; Homo sapiens; Mus musculus; synthetic construct mus musculus homo sapiens | homo sapiens Ma, Y., Tang, M., Ru, H., Song, G. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9b74 H L 0 NA NA NA NA IMMUNE SYSTEM 08/07/24 Crystal structure of humanized 44H10 Fab Version 14 Homo sapiens homo sapiens homo sapiens Kassardjian, A., Julien, J.P. 2.48 X-RAY DIFFRACTION 0.205 0.174 False True IGHV4 IGKV1 Kappa None None None None None 9b75 H L 0 NA NA NA NA IMMUNE SYSTEM 08/07/24 Crystal structure of humanized 44H10 Fab Version 17 Homo sapiens homo sapiens homo sapiens Kassardjian, A., Julien, J.P. 1.95 X-RAY DIFFRACTION 0.223 0.180 False True IGHV2 IGKV1 Kappa None None None None None 9b76 H L 0 NA NA NA NA IMMUNE SYSTEM 08/07/24 Crystal structure of humanized 44H10 Fab Version 21 Homo sapiens homo sapiens homo sapiens Kassardjian, A., Julien, J.P. 1.73 X-RAY DIFFRACTION 0.212 0.175 False True IGHV2 IGKV1 Kappa None None None None None 8k6m S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/31/24 Structural complex of neuropeptide Y receptor 1 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Shen, S.Y., Zhao, C., Shao, Z.H. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8k6n S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/31/24 Structural complex of neuropeptide Y receptor 2 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Shen, S.Y., Zhao, C., Shao, Z.H. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8k6o S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/31/24 Structural complex of neuropeptide Y receptor 1 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Shen, S.Y., Zhao, C., Shao, Z.H. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8k9b A B 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/31/24 SARS-CoV-2 spike protein in complex with one S2H5 Fab Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV1 Kappa None None None None None 8k9j A B 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/31/24 SARS-CoV-2 spike protein in complex with two S2H5 Fabs on NTD-1 and NTD-2 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 6.6 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV1 Kappa None None None None None 8k9j G F 0 D protein NA spike glycoprotein VIRAL PROTEIN 07/31/24 SARS-CoV-2 spike protein in complex with two S2H5 Fabs on NTD-1 and NTD-2 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 6.6 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV1 Kappa None None None None None 8k9m A B 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/31/24 SARS-CoV-2 spike protein in complex with two S2H5 Fabs on NTD-1 and NTD-3 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 6.8 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV1 Kappa None None None None None 8k9m G F 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/31/24 SARS-CoV-2 spike protein in complex with two S2H5 Fabs on NTD-1 and NTD-3 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 6.8 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV1 Kappa None None None None None 8kgg E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein subunit alpha-13 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/31/24 LPS-bound P2Y10 in complex with G13 Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Yin, Y. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8qkr B C 0 A protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.251 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Koekemoer, L., Draper, S.J. 3.234 X-RAY DIFFRACTION 0.327 0.254 False True IGHV1 IGKV1 Kappa None None None None None 8qkr E F 0 D protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.251 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Koekemoer, L., Draper, S.J. 3.234 X-RAY DIFFRACTION 0.327 0.254 False True IGHV1 IGKV1 Kappa None None None None None 8qks C B 0 A protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8qks F E 0 D protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8qks J I 0 H protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8qks L K 0 G protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8qks P O 0 N protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8qks R Q 0 M protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8qks V U 0 T protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8qks X W 0 S protein NA reticulocyte-binding protein-like protein 5 IMMUNE SYSTEM 07/31/24 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Wright, N.D., Barrett, J.R., Bradshaw, W.J., Paterson, N.G., MacLean, E.M., Ferreira, L., McHugh, K., Von Delft, F., Koekemoer, L., Draper, S.J. 3.994 X-RAY DIFFRACTION 0.458 0.441 False True IGHV3 IGLV1 Lambda None None None None None 8ry2 A B 0 NA NA NA NA CYTOKINE 07/31/24 Crystal Structure of ANV419, a novel IL-2/anti-IL-2 antibody fusion protein Homo sapiens homo sapiens homo sapiens Rondeau, J.M., Wirth, E. 2.05 X-RAY DIFFRACTION 0.224 0.190 False True IGHV5 IGKV1 Kappa None None None None None 8ry2 H L 0 NA NA NA NA CYTOKINE 07/31/24 Crystal Structure of ANV419, a novel IL-2/anti-IL-2 antibody fusion protein Homo sapiens homo sapiens homo sapiens Rondeau, J.M., Wirth, E. 2.05 X-RAY DIFFRACTION 0.224 0.190 False True IGHV5 IGKV1 Kappa None None None None None 8t59 A B 0 E peptide NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM/PEPTIDE BINDING PROTEIN 07/31/24 Crystal structure of Para.09 bound to TREM2 synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Wallweber, H., Hsu, P.L. 2 X-RAY DIFFRACTION 0.237 0.200 False True IGHV3 IGKV2 Kappa None None None None None 8t59 C D 0 F peptide NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM/PEPTIDE BINDING PROTEIN 07/31/24 Crystal structure of Para.09 bound to TREM2 synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Wallweber, H., Hsu, P.L. 2 X-RAY DIFFRACTION 0.237 0.200 False True IGHV3 IGKV2 Kappa None None None None None 8tmy H L 0 S peptide NA stem helix peptide of spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody CHM-16 Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.07 X-RAY DIFFRACTION 0.286 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8tmy A B 0 M peptide NA stem helix peptide of spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody CHM-16 Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.07 X-RAY DIFFRACTION 0.286 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8tmy C D 0 N peptide NA stem helix peptide of spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody CHM-16 Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Feng, Z., Wilson, I.A. 3.07 X-RAY DIFFRACTION 0.286 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8tmz H L 0 A peptide NA stem helix peptide of spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Crystal structure of MERS-CoV spike stem helix peptide in complex with neutralizing antibody CHM-27 Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta middle east respiratory syndrome-relatedcoronavirus Yuan, M., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.294 0.245 False True IGHV1 IGLV1 Lambda None None None None None 8tv2 D E 0 NA NA NA NA SIGNALING PROTEIN/IMMUNE SYSTEM 07/31/24 Structure of apo FabS1C_L1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 2.65 X-RAY DIFFRACTION 0.247 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8tv2 A B 0 NA NA NA NA SIGNALING PROTEIN/IMMUNE SYSTEM 07/31/24 Structure of apo FabS1C_L1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 2.65 X-RAY DIFFRACTION 0.247 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8vcr D F 0 C protein NA spike protein s2 VIRAL PROTEIN 07/31/24 SARS-CoV-2 Spike S2 bound to Fab 54043-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Johnson, N.V., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8vcr E G 0 A protein NA spike protein s2 VIRAL PROTEIN 07/31/24 SARS-CoV-2 Spike S2 bound to Fab 54043-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Johnson, N.V., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8vcr H L 0 B protein NA spike protein s2 VIRAL PROTEIN 07/31/24 SARS-CoV-2 Spike S2 bound to Fab 54043-5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Johnson, N.V., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8xx0 H L 0 H carbohydrate BOG B-OCTYLGLUCOSIDE IMMUNE SYSTEM 07/31/24 Crystal structure of anti-IgE antibody HMK-12 Fab complexed with IgE F(ab')2 Mus; Rattus rattus rattus rattus Hirano, T., Koyanagi, A., Kasai, M., Okumura, K. 2.9 X-RAY DIFFRACTION 0.267 0.225 False False IGHV3 IGKV16 Kappa None None None None None 8xx0 A B 0 NA NA NA NA IMMUNE SYSTEM 07/31/24 Crystal structure of anti-IgE antibody HMK-12 Fab complexed with IgE F(ab')2 Mus; Rattus mus mus Hirano, T., Koyanagi, A., Kasai, M., Okumura, K. 2.9 X-RAY DIFFRACTION 0.267 0.225 False False IGHV1 unknown unknown None None None None None 8yww H h 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 The structure of HKU1-B S protein with bsAb1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Xia, L.Y., Zhang, Y.Y., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yww E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 The structure of HKU1-B S protein with bsAb1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, L.Y., Zhang, Y.Y., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8yww G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 The structure of HKU1-B S protein with bsAb1 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, L.Y., Zhang, Y.Y., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ywx E D 0 A protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 the complex structure of the H4B6 Fab with the RBD of Omicron BA.5 S protein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, L.Y., Zhang, Y.Y., Zhou, Q. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9ber H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ber D E 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9ber J K 0 F protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with PGT122 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9bew C D 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.3 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9bew H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 9bew F I 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.3 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9bew J K 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 9bew O P 0 M protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.3 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 9bew Q R 0 M protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 9bf6 D E 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9bf6 G H 0 F protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9bf6 K L 0 J protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/31/24 Cryo-EM structure of the HIV-1 WITO IDL Env trimer in complex with PGT122 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 9f18 H L 0 NA NA NA NA IMMUNE SYSTEM 07/31/24 Crystal structure of a first-in-class antibody for alpha-1,6-fucosylated prostate-specific antigen Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Halldorsson, S. 2.52 X-RAY DIFFRACTION 0.251 0.184 False True IGHV1 IGKV1 Kappa None None None None None 9f18 I M 0 NA NA NA NA IMMUNE SYSTEM 07/31/24 Crystal structure of a first-in-class antibody for alpha-1,6-fucosylated prostate-specific antigen Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Halldorsson, S. 2.52 X-RAY DIFFRACTION 0.251 0.184 False True IGHV1 IGKV1 Kappa None None None None None 9f1i H L 0 P peptide NA prostate specific antigen IMMUNE SYSTEM 07/31/24 Crystal structure of a first-in-class antibody for alpha-1,6-fucosylated prostate-specific antigen, target bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Halldorsson, S. 1.38 X-RAY DIFFRACTION 0.187 0.155 False True IGHV1 IGKV1 Kappa None None None None None 9f1i I M 0 Q peptide NA prostate specific antigen IMMUNE SYSTEM 07/31/24 Crystal structure of a first-in-class antibody for alpha-1,6-fucosylated prostate-specific antigen, target bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Halldorsson, S. 1.38 X-RAY DIFFRACTION 0.187 0.155 False True IGHV1 IGKV1 Kappa None None None None None 9g13 A NA 0 B peptide NA isoform tau-f of microtubule-associated protein tau IMMUNE SYSTEM 01/08/09 VHH H3-2 in complex with Tau C-terminal peptide Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens Dupre, E., Landrieu, I., Danis, C., Hanoulle, X., Mortelecque, J. 1.8 X-RAY DIFFRACTION 0.231 0.172 False True IGHV3 NA NA None None None None None 9g13 E NA 0 F peptide NA isoform tau-f of microtubule-associated protein tau IMMUNE SYSTEM 01/08/09 VHH H3-2 in complex with Tau C-terminal peptide Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens Dupre, E., Landrieu, I., Danis, C., Hanoulle, X., Mortelecque, J. 1.8 X-RAY DIFFRACTION 0.231 0.172 False True IGHV3 NA NA None None None None None 9g13 C NA 0 D peptide NA isoform tau-f of microtubule-associated protein tau IMMUNE SYSTEM 01/08/09 VHH H3-2 in complex with Tau C-terminal peptide Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens Dupre, E., Landrieu, I., Danis, C., Hanoulle, X., Mortelecque, J. 1.8 X-RAY DIFFRACTION 0.231 0.172 False True IGHV3 NA NA None None None None None 9g13 G NA 0 H peptide NA isoform tau-f of microtubule-associated protein tau IMMUNE SYSTEM 01/08/09 VHH H3-2 in complex with Tau C-terminal peptide Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens Dupre, E., Landrieu, I., Danis, C., Hanoulle, X., Mortelecque, J. 1.8 X-RAY DIFFRACTION 0.231 0.172 False True IGHV3 NA NA None None None None None 9g7k C NA 0 B protein NA endoribonuclease mazf TOXIN 07/31/24 Staphylococcus aureus MazF in complex with Nanobody 12 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.08687 X-RAY DIFFRACTION 0.234 0.189 False True IGHV3 NA NA None None None None None 9g7k D NA 0 A protein NA endoribonuclease mazf TOXIN 07/31/24 Staphylococcus aureus MazF in complex with Nanobody 12 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.08687 X-RAY DIFFRACTION 0.234 0.189 False True IGHV3 NA NA None None None None None 9g7k G NA 0 F protein NA endoribonuclease mazf TOXIN 07/31/24 Staphylococcus aureus MazF in complex with Nanobody 12 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.08687 X-RAY DIFFRACTION 0.234 0.189 False True IGHV3 NA NA None None None None None 9g7k H NA 0 E protein NA endoribonuclease mazf TOXIN 07/31/24 Staphylococcus aureus MazF in complex with Nanobody 12 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.08687 X-RAY DIFFRACTION 0.234 0.189 False True IGHV3 NA NA None None None None None 7x35 H L 0 A | C | B protein | protein | protein NA | NA | NA virion protein 1 | vp3 | vp2 VIRUS 07/24/24 Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 8A10 (CVB1-A:8A10) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.19 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 8tgv E F 0 A protein NA envelope glycoprotein e2 ANTIVIRAL PROTEIN 07/24/24 CryoEM structure of Fab HC84.26-HCV E2 complex Hepacivirus C; Homo sapiens homo sapiens homo sapiens hepacivirus c Shahid, S., Liqun, J., LIu, Y., Hasan, S.S., Mariuzza, R.A. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8tgv B C 0 D protein NA envelope glycoprotein e2 ANTIVIRAL PROTEIN 07/24/24 CryoEM structure of Fab HC84.26-HCV E2 complex Hepacivirus C; Homo sapiens homo sapiens homo sapiens hepacivirus c Shahid, S., Liqun, J., LIu, Y., Hasan, S.S., Mariuzza, R.A. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8tgv I J 0 G protein NA envelope glycoprotein e2 ANTIVIRAL PROTEIN 07/24/24 CryoEM structure of Fab HC84.26-HCV E2 complex Hepacivirus C; Homo sapiens homo sapiens homo sapiens hepacivirus c Shahid, S., Liqun, J., LIu, Y., Hasan, S.S., Mariuzza, R.A. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8tgv K L 0 NA NA NA NA ANTIVIRAL PROTEIN 07/24/24 CryoEM structure of Fab HC84.26-HCV E2 complex Hepacivirus C; Homo sapiens homo sapiens homo sapiens Shahid, S., Liqun, J., LIu, Y., Hasan, S.S., Mariuzza, R.A. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8thz H L 0 A protein NA envelope glycoprotein e2 ANTIVIRAL PROTEIN 07/24/24 CryoEM structure of neutralizing antibodies CBH-7 and HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2 Hepacivirus C; Homo sapiens homo sapiens homo sapiens hepacivirus c Shahid, S., Jiang, L., Liu, Y., Hasan, S.S., Mariuzza, R.A. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8thz E F 0 A protein NA envelope glycoprotein e2 ANTIVIRAL PROTEIN 07/24/24 CryoEM structure of neutralizing antibodies CBH-7 and HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2 Hepacivirus C; Homo sapiens homo sapiens homo sapiens hepacivirus c Shahid, S., Jiang, L., Liu, Y., Hasan, S.S., Mariuzza, R.A. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8tjn C D 0 A protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 07/24/24 Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Soohoo, A.M., Chen, M., Brodsky, K.L., Liu, Y., Khosla, C. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8tjn E F 0 B protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 07/24/24 Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Soohoo, A.M., Chen, M., Brodsky, K.L., Liu, Y., Khosla, C. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8tjo C D 0 A protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 07/24/24 Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked Intra-State 1 Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Soohoo, A.M., Chen, M., Brodsky, K.L., Liu, Y., Khosla, C. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8tjo E F 0 B protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 07/24/24 Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked Intra-State 1 Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Soohoo, A.M., Chen, M., Brodsky, K.L., Liu, Y., Khosla, C. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8vif H L 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 SARS-CoV-2 spike omicron (BA.1) ectodomain trimer in complex with SC27 Fab, local refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Byrne, P.O., McLellan, J.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 8vke H L 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 SARS-CoV-2 spike omicron (BA.1) RBD ectodomain dimer-of-trimers in complex with SC27 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Byrne, P.O., McLellan, J.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 8vke A B 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 SARS-CoV-2 spike omicron (BA.1) RBD ectodomain dimer-of-trimers in complex with SC27 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Byrne, P.O., McLellan, J.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 8vm8 H L 0 R nucleic-acid NA rna (93-mer) RNA/Immune System 07/24/24 The crystal structure of coxsackievirus B3 RNA replication element sD-loop mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Das, N.K., Koirala, D. 1.54 X-RAY DIFFRACTION 0.213 0.186 False True IGHV3 IGKV1 Kappa None None None None None 8vm9 A B 0 C nucleic-acid NA rna (85-mer) RNA/Immune System 07/24/24 The crystal structure of rhinovirus B14 RNA replication element sD-loop mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Das, N.K., Koirala, D. 2.2 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGKV1 Kappa None None None None None 8vm9 H L 0 R nucleic-acid NA rna (85-mer) RNA/Immune System 07/24/24 The crystal structure of rhinovirus B14 RNA replication element sD-loop mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Das, N.K., Koirala, D. 2.2 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGKV1 Kappa None None None None None 8vma A B 0 C nucleic-acid NA rna (88-mer) RNA/Immune System 07/24/24 The crystal structure of rhinovirus C15 RNA replication element sD-loop mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Das, N.K., Koirala, D. 2.54 X-RAY DIFFRACTION 0.245 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8vma H L 0 R nucleic-acid NA rna (88-mer) RNA/Immune System 07/24/24 The crystal structure of rhinovirus C15 RNA replication element sD-loop mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Das, N.K., Koirala, D. 2.54 X-RAY DIFFRACTION 0.245 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8vmb H L 0 R nucleic-acid NA rna (83-mer) RNA/Immune System 07/24/24 The crystal structure of rhinovirus C15 RNA replication element sB-loop mutant in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Das, N.K., Koirala, D. 2.97 X-RAY DIFFRACTION 0.251 0.210 False True IGHV3 IGKV1 Kappa None None None None None 8vww B C 0 A protein NA gp38 VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 CCHFV GP38 bound to ADI-46152 and ADI-58048 Fabs Crimean-Congo hemorrhagic fever virus strain IbAr10200; Homo sapiens homo sapiens homo sapiens crimean-congo hemorrhagic fever virus strainibar10200 Hjorth, C.K., McLellan, J.S. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vww H L 0 A protein NA gp38 VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 CCHFV GP38 bound to ADI-46152 and ADI-58048 Fabs Crimean-Congo hemorrhagic fever virus strain IbAr10200; Homo sapiens homo sapiens homo sapiens crimean-congo hemorrhagic fever virus strainibar10200 Hjorth, C.K., McLellan, J.S. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8w4f D NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 SARS-CoV-2 spike protein in complex with a trivalent nanobody Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, X.Y., Qian, J.Q., Zhu, H.X., Qin, Q., Huang, Q. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8w4f E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 SARS-CoV-2 spike protein in complex with a trivalent nanobody Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, X.Y., Qian, J.Q., Zhu, H.X., Qin, Q., Huang, Q. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8w4f F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 SARS-CoV-2 spike protein in complex with a trivalent nanobody Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, X.Y., Qian, J.Q., Zhu, H.X., Qin, Q., Huang, Q. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8zgu H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/24/24 Crystal structural of HTNV Gn and AH100 Fab Homo sapiens; Orthohantavirus hantanense homo sapiens homo sapiens orthohantavirus hantanense Wang, F.R., Wu, Y., Gao, F. 3.51 X-RAY DIFFRACTION 0.295 0.253 False True IGHV4 IGLV1 Lambda None None None None None 8zsj N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/24/24 Cryo-EM structure of the apo hTAAR1-Gs complex Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Jiang, K.X., Zheng, Y., Xu, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zsp N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/24/24 Cryo-EM structure of the LSD-bound hTAAR1-Gs complex Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Jiang, K.X., Zheng, Y., Xu, F. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zss N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Jiang, K.X., Zheng, Y., Xu, F. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zsv N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the RO5263397-bound mTAAR1-Gs complex Escherichia coli; Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Jiang, K.X., Zheng, Y., Xu, F. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9bir B NA 0 A protein NA solute carrier family 15 member 2 MEMBRANE PROTEIN 01/08/09 Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cefadroxil Lama glama; Rattus norvegicus lama glama rattus norvegicus Parker, J.L., Deme, J.C., Lea, S.M., Newstead, S. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9bis B NA 0 A protein NA solute carrier family 15 member 2 MEMBRANE PROTEIN 07/24/24 Cryo-EM structure of the mammalian peptide transporter PepT2 bound to amoxicillin Lama glama; Rattus norvegicus lama glama rattus norvegicus Parker, J.L., Deme, J.C., Lea, S.M., Newstead, S. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9bit B NA 0 A protein NA solute carrier family 15 member 2 MEMBRANE PROTEIN 07/24/24 Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 1 Lama glama; Rattus norvegicus lama glama rattus norvegicus Parker, J.L., Deme, J.C., Lea, S.M., Newstead, S. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9biu B NA 0 A protein NA solute carrier family 15 member 2 MEMBRANE PROTEIN 07/24/24 Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 2 Lama glama; Rattus norvegicus lama glama rattus norvegicus Parker, J.L., Deme, J.C., Lea, S.M., Newstead, S. 2.9 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 9euo H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 01/08/09 Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor Drosophila melanogaster; Mus musculus mus musculus mus musculus drosophila melanogaster Pedersen, C.N., Yang, F., Ita, S., Xu, Y., Akunuri, R., Trampari, S., Neumann, C.M.T., Desdorf, L.M., Schioett, B., Salvino, J.M., Mortensen, O.V., Nissen, P., Shahsavar, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9eup H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 07/24/24 Inhibitor-free outward-open structure of Drosophila dopamine transporter Drosophila melanogaster; Mus musculus mus musculus mus musculus drosophila melanogaster Pedersen, C.N., Yang, F., Ita, S., Xu, Y., Akunuri, R., Trampari, S., Neumann, C.M.T., Desdorf, L.M., Schioett, B., Salvino, J.M., Mortensen, O.V., Nissen, P., Shahsavar, A. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 9g1y C NA 0 A protein NA endoribonuclease mazf TOXIN 07/24/24 Staphycoccus aureus MazF in complex with Nabobody 3 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.69655 X-RAY DIFFRACTION 0.274 0.216 False True IGHV1 NA NA None None None None None 9g1y D NA 0 B protein NA endoribonuclease mazf TOXIN 07/24/24 Staphycoccus aureus MazF in complex with Nabobody 3 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.69655 X-RAY DIFFRACTION 0.274 0.216 False True IGHV1 NA NA None None None None None 9g2g C NA 0 A protein NA endoribonuclease mazf TOXIN 07/24/24 Staphylococcus aureus MazF in complex with nanobody 5 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Prolic-Kalinsek, M., Zorzini, V., Haesaerts, S., Loris, R. 1.80048 X-RAY DIFFRACTION 0.244 0.195 False True IGHV1 NA NA None None None None None 9g2g D NA 0 B protein NA endoribonuclease mazf TOXIN 07/24/24 Staphylococcus aureus MazF in complex with nanobody 5 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Prolic-Kalinsek, M., Zorzini, V., Haesaerts, S., Loris, R. 1.80048 X-RAY DIFFRACTION 0.244 0.195 False True IGHV1 NA NA None None None None None 9g48 C NA 0 A protein NA endoribonuclease mazf TOXIN 07/24/24 Staphylococcus aureus MazF in complex with Nanobody 6 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.14354 X-RAY DIFFRACTION 0.245 0.216 False True IGHV1 NA NA None None None None None 9g48 D NA 0 B protein NA endoribonuclease mazf TOXIN 07/24/24 Staphylococcus aureus MazF in complex with Nanobody 6 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.14354 X-RAY DIFFRACTION 0.245 0.216 False True IGHV1 NA NA None None None None None 9g4g B NA 0 A protein NA endoribonuclease mazf TOXIN 07/24/24 Staphylococcus aureus MazF in complex with Nanobody 9 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Zorzini, V., Haesaerts, S., Loris, R. 2.89573 X-RAY DIFFRACTION 0.303 0.253 False True IGHV1 NA NA None None None None None 9g5l B NA 0 A protein NA endoribonuclease mazf TOXIN 07/24/24 Stapylococcus aureus MazF in complex with nanobody 10 Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Prolic-Kalinsek, M., Haesaerts, S., Loris, R. 1.8222 X-RAY DIFFRACTION 0.228 0.201 False True IGHV1 NA NA None None None None None 9g5z C NA 0 A protein NA endoribonuclease mazf TOXIN 07/24/24 Nanobody-mediated activation and inhibition of Staphylococcus aureus MazF Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Prolic-Kalinsek, M., Haesaerts, S., Loris, R. 3.42909 X-RAY DIFFRACTION 0.283 0.244 False True IGHV3 NA NA None None None None None 9g5z D NA 0 B protein NA endoribonuclease mazf TOXIN 07/24/24 Nanobody-mediated activation and inhibition of Staphylococcus aureus MazF Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Prolic-Kalinsek, M., Haesaerts, S., Loris, R. 3.42909 X-RAY DIFFRACTION 0.283 0.244 False True IGHV3 NA NA None None None None None 8udz C D 0 B protein NA transforming growth factor beta-1 proprotein SIGNALING PROTEIN/IMMUNE SYSTEM 07/17/24 The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex Homo sapiens homo sapiens homo sapiens homo sapiens Streich Jr., F.C., Nicholls, S.B., Boston, C.J., Ramachandran, S. 2.21 X-RAY DIFFRACTION 0.264 0.232 False True IGHV3 IGLV6 Lambda None None None None None 8udz E F 0 B | A protein | protein NA | NA transforming growth factor beta-1 proprotein | transforming growth factor beta-1 proprotein SIGNALING PROTEIN/IMMUNE SYSTEM 07/17/24 The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Streich Jr., F.C., Nicholls, S.B., Boston, C.J., Ramachandran, S. 2.21 X-RAY DIFFRACTION 0.264 0.232 False True IGHV3 IGLV6 Lambda None None None None None 8vyl F NA 0 D | C protein | protein NA | NA hemoglobin subunit beta | hemoglobin subunit alpha OXYGEN TRANSPORT 07/17/24 The structure of Human Hemoglobin in Complex with Nanobody BtNbE11 Escherichia coli; Homo sapiens homo sapiens | homo sapiens Grinter, R., Binks, S., Fox, D. 2.02 X-RAY DIFFRACTION 0.266 0.208 False True IGHV1 NA NA None None None None None 8vyl E NA 0 B | A protein | protein NA | NA hemoglobin subunit beta | hemoglobin subunit alpha OXYGEN TRANSPORT 07/17/24 The structure of Human Hemoglobin in Complex with Nanobody BtNbE11 Escherichia coli; Homo sapiens homo sapiens | homo sapiens Grinter, R., Binks, S., Fox, D. 2.02 X-RAY DIFFRACTION 0.266 0.208 False True IGHV1 NA NA None None None None None 8q5y R L 0 D protein NA spike glycoprotein VIRAL PROTEIN 07/17/24 cryoEM structure of SARS-CoV2 Spike trimer in complex with Fab23 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hallberg, M., Das, H. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8q5y G H 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/17/24 cryoEM structure of SARS-CoV2 Spike trimer in complex with Fab23 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hallberg, M., Das, H. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8q5y B A 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/17/24 cryoEM structure of SARS-CoV2 Spike trimer in complex with Fab23 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hallberg, M., Das, H. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8k33 B NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 D NA 0 C protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 F NA 0 E protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 H NA 0 G protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 J NA 0 I protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 M NA 0 L protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 O NA 0 N protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 Q NA 0 K protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 R NA 0 P protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 T NA 0 Y protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 V NA 0 U protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k33 X NA 0 W protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody1 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cheng, S. 2.13 X-RAY DIFFRACTION 0.265 0.217 False True IGHV1 NA NA None None None None None 8k3a B NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody2 complex Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Cheng, S. 2.74 X-RAY DIFFRACTION 0.256 0.234 False True IGHV1 NA NA None None None None None 8k3l B NA 0 A protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody3 complex Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Cheng, S., Liu, R., Ding, Y. 2.3 X-RAY DIFFRACTION 0.235 0.195 False True IGHV1 NA NA None None None None None 8k3l D NA 0 C protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody3 complex Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Cheng, S., Liu, R., Ding, Y. 2.3 X-RAY DIFFRACTION 0.235 0.195 False True IGHV1 NA NA None None None None None 8k3l F NA 0 E protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody3 complex Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Cheng, S., Liu, R., Ding, Y. 2.3 X-RAY DIFFRACTION 0.235 0.195 False True IGHV1 NA NA None None None None None 8k3l H NA 0 G protein NA superoxide dismutase [cu-zn] OXIDOREDUCTASE/IMMUNE SYSTEM 07/17/24 SOD1 and Nanobody3 complex Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Cheng, S., Liu, R., Ding, Y. 2.3 X-RAY DIFFRACTION 0.235 0.195 False True IGHV1 NA NA None None None None None 8k3z S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 07/17/24 Cryo-EM structure of CXCR4 in complex with CXCL12 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Liu, Y.Z., Liu, A.J., Liao, Q.W., Ye, R.D. 2.81 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8rz0 B b 0 A protein NA rh5-34em IMMUNE SYSTEM 07/17/24 Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.016 Homo sapiens; synthetic construct homo sapiens synthetic construct Farrell, B., Harrison, T., Higgins, M.K. 1.63 X-RAY DIFFRACTION 0.206 0.191 True True unknown unknown unknown None None None None None 8rz0 D d 0 C protein NA rh5-34em IMMUNE SYSTEM 07/17/24 Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.016 Homo sapiens; synthetic construct homo sapiens synthetic construct Farrell, B., Harrison, T., Higgins, M.K. 1.63 X-RAY DIFFRACTION 0.206 0.191 True True unknown unknown unknown None None None None None 8rz0 F f 0 E protein NA rh5-34em IMMUNE SYSTEM 07/17/24 Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.016 Homo sapiens; synthetic construct homo sapiens synthetic construct Farrell, B., Harrison, T., Higgins, M.K. 1.63 X-RAY DIFFRACTION 0.206 0.191 True True unknown unknown unknown None None None None None 8rz0 H h 0 G protein NA rh5-34em IMMUNE SYSTEM 07/17/24 Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.016 Homo sapiens; synthetic construct homo sapiens synthetic construct Farrell, B., Harrison, T., Higgins, M.K. 1.63 X-RAY DIFFRACTION 0.206 0.191 True True unknown unknown unknown None None None None None 8rz1 A a 0 B protein NA rh5-34em IMMUNE SYSTEM 07/17/24 Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.034 Homo sapiens; synthetic construct homo sapiens synthetic construct Farrell, B., Higgins, M.K. 1.75 X-RAY DIFFRACTION 0.218 0.198 True True unknown unknown unknown None None None None None 8rz1 C c 0 D protein NA rh5-34em IMMUNE SYSTEM 07/17/24 Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.034 Homo sapiens; synthetic construct homo sapiens synthetic construct Farrell, B., Higgins, M.K. 1.75 X-RAY DIFFRACTION 0.218 0.198 True True unknown unknown unknown None None None None None 8rz2 B C 0 A protein NA reticulocyte binding protein 5 IMMUNE SYSTEM 07/17/24 PfRH5 bound to monoclonal antibody R5.034 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Farrell, B., Higgins, M.K. 2.4 X-RAY DIFFRACTION 0.305 0.255 False True IGHV3 IGLV1 Lambda None None None None None 8tfe A B 0 NA NA NA NA IMMUNE SYSTEM 07/17/24 Crystal structure of Fab fragment of anti-HCV E2 antibody (CBH-7) Homo sapiens homo sapiens homo sapiens Shahid, S., Mariuzza, R.A. 1.62 X-RAY DIFFRACTION 0.214 0.177 False True IGHV1 IGKV1 Kappa None None None None None 8tfe C D 0 NA NA NA NA IMMUNE SYSTEM 07/17/24 Crystal structure of Fab fragment of anti-HCV E2 antibody (CBH-7) Homo sapiens homo sapiens homo sapiens Shahid, S., Mariuzza, R.A. 1.62 X-RAY DIFFRACTION 0.214 0.177 False True IGHV1 IGKV1 Kappa None None None None None 8tg9 H L 0 A protein NA atrial natriuretic peptide receptor 1 IMMUNE SYSTEM 07/17/24 Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Franklin, M.C., Romero Hernandez, A. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8tg9 E F 0 B protein NA atrial natriuretic peptide receptor 1 IMMUNE SYSTEM 07/17/24 Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Franklin, M.C., Romero Hernandez, A. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8tga E F 0 B protein NA atrial natriuretic peptide receptor 1 IMMUNE SYSTEM 07/17/24 Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Franklin, M.C., Romero Hernandez, A. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8tga H L 0 A protein NA atrial natriuretic peptide receptor 1 IMMUNE SYSTEM 07/17/24 Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Franklin, M.C., Romero Hernandez, A. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8trv C G 0 A protein NA ephrin type-a receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 07/17/24 Structure of the EphA2 LBDCRD bound to FabS1C_C1 Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.25 X-RAY DIFFRACTION 0.272 0.217 False True IGHV3 IGKV1 Kappa None None None None None 8trv D E 0 B protein NA ephrin type-a receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 07/17/24 Structure of the EphA2 LBDCRD bound to FabS1C_C1 Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.25 X-RAY DIFFRACTION 0.272 0.217 False True IGHV3 IGKV1 Kappa None None None None None 8vvk D C 0 B protein NA gp38 VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 CCHFV GP38 bound to ADI-46143 Fab Crimean-Congo hemorrhagic fever virus; Homo sapiens homo sapiens homo sapiens crimean-congo hemorrhagic fever virus Hjorth, C.K., McLellan, J.S. 2.61 X-RAY DIFFRACTION 0.217 0.177 False True IGHV4 IGLV3 Lambda None None None None None 8vvk H L 0 A protein NA gp38 VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 CCHFV GP38 bound to ADI-46143 Fab Crimean-Congo hemorrhagic fever virus; Homo sapiens homo sapiens homo sapiens crimean-congo hemorrhagic fever virus Hjorth, C.K., McLellan, J.S. 2.61 X-RAY DIFFRACTION 0.217 0.177 False True IGHV4 IGLV3 Lambda None None None None None 8vvl H L 0 A protein NA gp38 VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 CCHFV GP38 bound to c13G8 Fab Crimean-Congo hemorrhagic fever virus; Mus musculus mus musculus mus musculus crimean-congo hemorrhagic fever virus Hjorth, C.K., Mishra, A.K., McLellan, J.S. 1.8 X-RAY DIFFRACTION 0.215 0.200 False True IGHV2 IGKV4 Kappa None None None None None 8w1v D NA 0 A protein NA beta-2 adrenergic receptor,endolysin MEMBRANE PROTEIN 01/08/09 The beta2 adrenergic receptor bound to a bitopic ligand Homo sapiens; Lama glama lama glama homo sapiens Gaiser, B., Danielsen, M., Xu, X., Jorgensen, K., Fronik, P., Marcher-Rorsted, E., Wrobe, T., Hirata, K., Liu, X., Mathiesen, J., Pedersen, D. 3 X-RAY DIFFRACTION 0.292 0.248 False True IGHV1 NA NA None None None None None 8w1v F NA 0 B protein NA beta-2 adrenergic receptor,endolysin MEMBRANE PROTEIN 01/08/09 The beta2 adrenergic receptor bound to a bitopic ligand Homo sapiens; Lama glama lama glama homo sapiens Gaiser, B., Danielsen, M., Xu, X., Jorgensen, K., Fronik, P., Marcher-Rorsted, E., Wrobe, T., Hirata, K., Liu, X., Mathiesen, J., Pedersen, D. 3 X-RAY DIFFRACTION 0.292 0.248 False True IGHV1 NA NA None None None None None 8x7n B NA 0 A protein NA conjugative transfer ANTIMICROBIAL PROTEIN 07/17/24 Cell-cell adhesion Nanobody/Antigen Pair Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; synthetic construct synthetic construct salmonella enterica subsp. enterica serovartyphimurium str. lt2 Chen, P.-P., Hsia, K.-C., Ting, S.-Y., Chen, Y.-C. 3.67 X-RAY DIFFRACTION 0.285 0.260 False True IGHV1 NA NA None None None None None 8x7n D NA 0 C protein NA conjugative transfer ANTIMICROBIAL PROTEIN 07/17/24 Cell-cell adhesion Nanobody/Antigen Pair Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; synthetic construct synthetic construct salmonella enterica subsp. enterica serovartyphimurium str. lt2 Chen, P.-P., Hsia, K.-C., Ting, S.-Y., Chen, Y.-C. 3.67 X-RAY DIFFRACTION 0.285 0.260 False True IGHV1 NA NA None None None None None 8x7n F NA 0 E protein NA conjugative transfer ANTIMICROBIAL PROTEIN 07/17/24 Cell-cell adhesion Nanobody/Antigen Pair Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; synthetic construct synthetic construct salmonella enterica subsp. enterica serovartyphimurium str. lt2 Chen, P.-P., Hsia, K.-C., Ting, S.-Y., Chen, Y.-C. 3.67 X-RAY DIFFRACTION 0.285 0.260 False True IGHV1 NA NA None None None None None 8x7n H NA 0 G protein NA conjugative transfer ANTIMICROBIAL PROTEIN 07/17/24 Cell-cell adhesion Nanobody/Antigen Pair Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; synthetic construct synthetic construct salmonella enterica subsp. enterica serovartyphimurium str. lt2 Chen, P.-P., Hsia, K.-C., Ting, S.-Y., Chen, Y.-C. 3.67 X-RAY DIFFRACTION 0.285 0.260 False True IGHV1 NA NA None None None None None 8x7n J NA 0 I protein NA conjugative transfer ANTIMICROBIAL PROTEIN 07/17/24 Cell-cell adhesion Nanobody/Antigen Pair Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; synthetic construct synthetic construct salmonella enterica subsp. enterica serovartyphimurium str. lt2 Chen, P.-P., Hsia, K.-C., Ting, S.-Y., Chen, Y.-C. 3.67 X-RAY DIFFRACTION 0.285 0.260 False True IGHV1 NA NA None None None None None 8xse H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tong, Z., Cui, Y., Xie, Y., Tong, J., Gao, G.F., Qi, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xse M N 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 SARS-CoV-2 RBD + IMCAS-123 + IMCAS-72 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tong, Z., Cui, Y., Xie, Y., Tong, J., Gao, G.F., Qi, J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xsf H L 0 B protein NA spike protein s1 VIRAL PROTEIN/HYDROLASE/IMMUNE SYSTEM 07/17/24 SARS-CoV-2 RBD + IMCAS-364 + hACE2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tong, Z., Cui, Y., Xie, Y., Tong, J., Gao, G.F., Qi, J. 2.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xsi H L 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 SARS-CoV-2 RBD + IMCAS-364 (Local Refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tong, Z., Cui, Y., Xie, Y., Tong, J., Gao, G.F., Qi, J. 2.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xsj H L 0 B protein NA spike protein s1 VIRAL PROTEIN/HYDROLASE/IMMUNE SYSTEM 07/17/24 SARS-CoV-2 Omicron BA.4 RBD + IMCAS-316 + ACE2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tong, Z., Cui, Y., Xie, Y., Tong, J., Gao, G.F., Qi, J. 2.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xsl H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 SARS-CoV-2 spike + IMCAS-123 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tong, Z., Cui, Y., Xie, Y., Tong, J., Gao, G.F., Qi, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xsl M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/17/24 SARS-CoV-2 spike + IMCAS-123 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tong, Z., Cui, Y., Xie, Y., Tong, J., Gao, G.F., Qi, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9bjk N NA 0 R protein NA mu-type opioid receptor MEMBRANE PROTEIN 01/08/09 Inactive mu opioid receptor bound to Nb6, naloxone and NAM Lama glama; Mus musculus lama glama mus musculus O'Brien, E.S., Wang, H., Kaavya Krishna, K., Zhang, C., Kobilka, B.K. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9fzc C NA 0 A protein NA outer membrane protein a MEMBRANE PROTEIN 07/17/24 Structure of OmpA-short in complex with nanobody Nb01 Escherichia coli K-12; Vicugna pacos vicugna pacos escherichia coli k-12 Ackle, F., Sorgenfrei, M., Seeger, M.A. 2.27 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 9fzc D NA 0 B protein NA outer membrane protein a MEMBRANE PROTEIN 07/17/24 Structure of OmpA-short in complex with nanobody Nb01 Escherichia coli K-12; Vicugna pacos vicugna pacos escherichia coli k-12 Ackle, F., Sorgenfrei, M., Seeger, M.A. 2.27 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 9fzd B NA 0 A protein NA outer membrane protein a MEMBRANE PROTEIN 07/17/24 Structure of OmpA-long in complex with nanobody Nb39 Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Ackle, F., Sorgenfrei, M., Seeger, M.A. 2.3 X-RAY DIFFRACTION 0.283 0.256 False True unknown unknown unknown None None None None None 9g2a C NA 0 A protein NA endoribonuclease mazf TOXIN 07/17/24 Staphylococcus aureus MazF in complex with nanobody 4 Lama glama; Staphylococcus aureus subsp. aureus N315 lama glama staphylococcus aureus subsp. aureus n315 Prolic-Kalinsek, M., Zorzini, V., Haesaerts, S., Loris, R. 2.04659 X-RAY DIFFRACTION 0.307 0.240 False True IGHV1 NA NA None None None None None 9g2a D NA 0 B protein NA endoribonuclease mazf TOXIN 07/17/24 Staphylococcus aureus MazF in complex with nanobody 4 Lama glama; Staphylococcus aureus subsp. aureus N315 lama glama staphylococcus aureus subsp. aureus n315 Prolic-Kalinsek, M., Zorzini, V., Haesaerts, S., Loris, R. 2.04659 X-RAY DIFFRACTION 0.307 0.240 False True IGHV1 NA NA None None None None None 8pn0 A B 0 F | E protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN 01/08/09 HEV gt3 P domain in complex with glycan-sensitive nAb p60.12 Homo sapiens; Paslahepevirus balayani homo sapiens homo sapiens paslahepevirus balayani | paslahepevirus balayani Ssebyatika, G., Krey, T. 2.072 X-RAY DIFFRACTION 0.261 0.226 False True IGHV1 IGLV2 Lambda None None None None None 8pn0 H L 0 D | C protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN 01/08/09 HEV gt3 P domain in complex with glycan-sensitive nAb p60.12 Homo sapiens; Paslahepevirus balayani homo sapiens homo sapiens paslahepevirus balayani | paslahepevirus balayani Ssebyatika, G., Krey, T. 2.072 X-RAY DIFFRACTION 0.261 0.226 False True IGHV1 IGLV2 Lambda None None None None None 8jza A NA 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Crystal structure of single domain antibody kt75 of human Thyroglobulin Camelus dromedarius camelus dromedarius Mistry, H., Kumarasamy, J., Kumari, S., Kulkarni, S.P., Gupta, G.D. 1.35 X-RAY DIFFRACTION 0.174 0.130 False True unknown unknown unknown None None None None None 8p2t H L 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Bovine naive ultralong antibody AbD08* collected at 100K Bos taurus bos taurus bos taurus Clarke, J.D., Douangamath, A., Mikolajek, H., Stuart, D.I., Owens, R.J. 1.45 X-RAY DIFFRACTION 0.206 0.148 False True IGHV1 IGLV1 Lambda None None None None None 8p6h H L 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Bovine naive ultralong antibody AbBLV5B8* collected at 100K Bos taurus bos taurus bos taurus Clarke, J.D., Douangamath, A., Mikolajek, H., Stuart, D.I., Owens, R.J. 1.46 X-RAY DIFFRACTION 0.261 0.222 False True IGHV1 IGLV1 Lambda None None None None None 8pmx H L 0 A | B protein | protein NA | NA pro-secreted protein orf2 | pro-secreted protein orf2 VIRAL PROTEIN 07/10/24 rat HEV P domain in complex with glycan-sensitive nAb p60.12 Hepatitis E virus rat/R63/DEU/2009; Homo sapiens homo sapiens homo sapiens hepatitis e virus rat/r63/deu/2009 | hepatitis e virus rat/r63/deu/2009 Ssebyatika, G., Krey, T. 3.922 X-RAY DIFFRACTION 0.362 0.300 False True IGHV1 IGLV2 Lambda None None None None None 8pmz B b 0 A protein NA pro-secreted protein orf2 VIRAL PROTEIN 07/10/24 HEV gt3 P domain in complex with glycan-insensitive nAb p61.15 Homo sapiens; Paslahepevirus balayani homo sapiens paslahepevirus balayani Ssebyatika, G., Krey, T. 1.912 X-RAY DIFFRACTION 0.257 0.225 True True unknown unknown unknown None None None None None 8pmz D d 0 C protein NA pro-secreted protein orf2 VIRAL PROTEIN 07/10/24 HEV gt3 P domain in complex with glycan-insensitive nAb p61.15 Homo sapiens; Paslahepevirus balayani homo sapiens paslahepevirus balayani Ssebyatika, G., Krey, T. 1.912 X-RAY DIFFRACTION 0.257 0.225 True True unknown unknown unknown None None None None None 8tdx A D 0 E peptide NA env fusion peptide IMMUNE SYSTEM 07/10/24 TRNM-b.01 in complex with HIV Env fusion peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Olia, A.S., Kwong, P.D. 2.09 X-RAY DIFFRACTION 0.240 0.204 False True unknown IGKV1 Kappa None None None None None 8tdx B C 0 F peptide NA env fusion peptide IMMUNE SYSTEM 07/10/24 TRNM-b.01 in complex with HIV Env fusion peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Olia, A.S., Kwong, P.D. 2.09 X-RAY DIFFRACTION 0.240 0.204 False True unknown IGKV1 Kappa None None None None None 8te7 B C 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of TRNM-f.01 Macaca mulatta macaca mulatta macaca mulatta Bender, M.F., Olia, A.S., Kwong, P.D. 3.18 X-RAY DIFFRACTION 0.263 0.233 False True IGHV4 IGKV1 Kappa None None None None None 8vtp A G 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE-EPR-1, a high affinity antibody for the erythropoeitin receptor Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sidhu, S.S. 1.77 X-RAY DIFFRACTION 0.195 0.175 False True IGHV3 IGKV1 Kappa None None None None None 8vtr A NA 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE3-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor (orthorhombic form) Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 1.96 X-RAY DIFFRACTION 0.228 0.187 False True IGHV3 NA NA None None None None None 8vtr NA G 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE3-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor (orthorhombic form) Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 1.96 X-RAY DIFFRACTION 0.228 0.187 False True NA IGKV1 Kappa None None None None None 8vu1 A NA 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE3-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor (trigonal form) Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 3.08 X-RAY DIFFRACTION 0.277 0.236 False True IGHV3 NA NA None None None None None 8vu1 NA G 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE3-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor (trigonal form) Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 3.08 X-RAY DIFFRACTION 0.277 0.236 False True NA IGKV1 Kappa None None None None None 8vu4 B C 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE4-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 2.35 X-RAY DIFFRACTION 0.252 0.208 False True IGHV3 IGKV1 Kappa None None None None None 8vu4 A G 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE4-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 2.35 X-RAY DIFFRACTION 0.252 0.208 False True IGHV3 IGKV1 Kappa None None None None None 8vua NA G 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE1-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 3.27 X-RAY DIFFRACTION 0.282 0.245 False True NA IGKV1 Kappa None None None None None 8vua A NA 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE1-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor Homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 3.27 X-RAY DIFFRACTION 0.282 0.245 False True IGHV3 NA NA None None None None None 8vuc A G 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE2-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 2.5 X-RAY DIFFRACTION 0.265 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8vuc B C 0 NA NA NA NA IMMUNE SYSTEM 07/10/24 Structure of FabS1CE2-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 2.5 X-RAY DIFFRACTION 0.265 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8vui A G 0 D protein NA erythropoietin receptor IMMUNE SYSTEM 07/10/24 Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sidhu, S.S. 2.1 X-RAY DIFFRACTION 0.240 0.197 False True IGHV3 IGKV1 Kappa None None None None None 8vvm A G 0 I protein NA erythropoietin receptor IMMUNE SYSTEM 07/10/24 Structure of FabS1CE1-EPR1-1 in complex with the erythropoietin receptor Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 2.9 X-RAY DIFFRACTION 0.273 0.219 False True IGHV3 IGKV1 Kappa None None None None None 8vvm B C 0 I protein NA erythropoietin receptor IMMUNE SYSTEM 07/10/24 Structure of FabS1CE1-EPR1-1 in complex with the erythropoietin receptor Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 2.9 X-RAY DIFFRACTION 0.273 0.219 False True IGHV3 IGKV1 Kappa None None None None None 8vvo A G 0 I protein NA erythropoietin receptor IMMUNE SYSTEM 07/10/24 Structure of FabS1CE2-EPR1-1 in complex with the erythropoietin receptor Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 3.09 X-RAY DIFFRACTION 0.289 0.253 False True IGHV3 IGKV1 Kappa None None None None None 8vvo B C 0 I protein NA erythropoietin receptor IMMUNE SYSTEM 07/10/24 Structure of FabS1CE2-EPR1-1 in complex with the erythropoietin receptor Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Pavlenco, A., Ploder, L., Luu, G., Blazer, L., Adams, J.J., Sidhu, S.S. 3.09 X-RAY DIFFRACTION 0.289 0.253 False True IGHV3 IGKV1 Kappa None None None None None 8xk2 B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 A neutralizing nanobody VHH60 against wt SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Lu, Y., Guo, H., Ji, X., Yang, H. 3.4 X-RAY DIFFRACTION 0.300 0.256 False True IGHV3 NA NA None None None None None 8xk2 D NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 A neutralizing nanobody VHH60 against wt SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Lu, Y., Guo, H., Ji, X., Yang, H. 3.4 X-RAY DIFFRACTION 0.300 0.256 False True IGHV3 NA NA None None None None None 8xk2 F NA 0 E protein NA spike protein s1 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 A neutralizing nanobody VHH60 against wt SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Lu, Y., Guo, H., Ji, X., Yang, H. 3.4 X-RAY DIFFRACTION 0.300 0.256 False True IGHV3 NA NA None None None None None 8xk2 H NA 0 G protein NA spike protein s1 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 A neutralizing nanobody VHH60 against wt SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Lu, Y., Guo, H., Ji, X., Yang, H. 3.4 X-RAY DIFFRACTION 0.300 0.256 False True IGHV3 NA NA None None None None None 8xk5 A B 0 E protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 SNB1G11 Fab bound to SFTSV glycoprotein Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Deng, Z. 3.05 X-RAY DIFFRACTION 0.281 0.215 False True IGHV7 IGKV10 Kappa None None None None None 8xk5 C D 0 F protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 SNB1G11 Fab bound to SFTSV glycoprotein Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Deng, Z. 3.05 X-RAY DIFFRACTION 0.281 0.215 False True IGHV7 IGKV10 Kappa None None None None None 8xk5 I J 0 K protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 SNB1G11 Fab bound to SFTSV glycoprotein Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Deng, Z. 3.05 X-RAY DIFFRACTION 0.281 0.215 False True IGHV7 IGKV10 Kappa None None None None None 8xk5 N O 0 R protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 SNB1G11 Fab bound to SFTSV glycoprotein Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Deng, Z. 3.05 X-RAY DIFFRACTION 0.281 0.215 False True IGHV7 IGKV10 Kappa None None None None None 8xk5 G H 0 L protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 SNB1G11 Fab bound to SFTSV glycoprotein Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Deng, Z. 3.05 X-RAY DIFFRACTION 0.281 0.215 False True IGHV7 IGKV10 Kappa None None None None None 8xk6 H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 S2A5 Fab bound to SFTSV glycoprotein Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Deng, Z. 2.45 X-RAY DIFFRACTION 0.250 0.231 False True IGHV1 IGKV3 Kappa None None None None None 8xk8 H L 0 A protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 N1D10 Fab bound to SFTSV glycoprotein-Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Zhao, H., Deng, Z. 3.53 X-RAY DIFFRACTION 0.324 0.250 False True IGHV5 IGKV1 Kappa None None None None None 8xk8 C D 0 B protein NA envelopment polyprotein VIRAL PROTEIN 07/10/24 N1D10 Fab bound to SFTSV glycoprotein-Gn Mus musculus; Severe fever with thrombocytopenia syndrome virus mus musculus mus musculus severe fever with thrombocytopenia syndromevirus Zhao, H., Deng, Z. 3.53 X-RAY DIFFRACTION 0.324 0.250 False True IGHV5 IGKV1 Kappa None None None None None 8xki D NA 0 C protein NA spike glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 A neutralizing nanobody VHH60 against wt SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Lu, Y., Guo, H., Ji, X., Yang, H. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xn9 H D 0 A protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 1.99 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8xn9 G E 0 C protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 1.99 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8xn9 I F 0 B protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 1.99 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8xnh I D 0 C protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 5C8 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8xnh H E 0 A protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 5C8 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8xnh G F 0 B protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/10/24 Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 5C8 Henipavirus nipahense; Macaca macaca macaca henipavirus nipahense Fan, P.F., Ren, Y., Yu, C.M., Chen, W. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8xql N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/10/24 Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Hu, X.L., Wu, L.J., Hua, T., Liu, Z.J. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xqn S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/10/24 Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Hu, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.05 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xqo S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/10/24 Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Hu, X.L., Wu, L.J., Hua, T., Liu, Z.J. 2.77 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xqp S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/10/24 Structure of human class T GPCR TAS2R14-Gustducin complex with Aristolochic acid A. Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens | homo sapiens Hu, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.29 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xqr N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/10/24 Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Hu, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xqs S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/10/24 Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Hu, X.L., Wu, L.J., Hua, T., Liu, Z.J. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xqt S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/10/24 Structure of human class T GPCR TAS2R14-Gi complex. Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Hu, X.L., Pei, Y., Wu, L.J., Hua, T., Liu, Z.J. 2.94 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yky S s 0 A | C | B protein | protein | protein NA | NA | NA g alpha gustducin protein | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/08/09 Structure of human class T GPCR TAS2R14-Ggustducin complex with agonist 28.1 Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens | homo sapiens Hu, X.L., Wu, L.J., Hua, T., Liu, Z.J. 2.99 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zbe E e 0 B | D | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein subunit gamma | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/10/24 cryo-EM structure of the octreotide-bound SSTR5-Gi complex Homo sapiens; Oplophorus gracilirostris; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | rattus norvegicus | rattus norvegicus Li, Y.G., Meng, X.Y., Yang, X.R., Ling, S.L., Shi, P., Tian, C.L., Yang, F. 3.24 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zcj E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/10/24 Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex Bos taurus; Homo sapiens; Oplophorus gracilirostris; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | rattus norvegicus Li, Y.G., Meng, X.Y., Yang, X.R., Ling, S.L., Shi, P., Tian, C.L., Yang, F. 3.09 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zqe S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/10/24 Cryo-EM structure of the GPR15L(C11)-bound GPR15 complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Zhang, Z.Y., Zheng, Y., Xu, F. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ut2 H G 0 B | A protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN 07/03/24 Pre-fusion Measles virus fusion protein complexed with Fab 77 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus Zyla, D., Saphire, E.O. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV16 Kappa None None None None None 8ut2 J I 0 D | C protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN 07/03/24 Pre-fusion Measles virus fusion protein complexed with Fab 77 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus Zyla, D., Saphire, E.O. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV16 Kappa None None None None None 8ut2 L K 0 F | E protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN 07/03/24 Pre-fusion Measles virus fusion protein complexed with Fab 77 Measles morbillivirus; Mus musculus mus musculus mus musculus measles morbillivirus | measles morbillivirus Zyla, D., Saphire, E.O. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV16 Kappa None None None None None 8oyt E NA 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 01/08/09 Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation Lama glama; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 lama glama severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Weckener, M., Naismith, J.H., Owens, R.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8oyt G NA 0 B protein NA spike glycoprotein,fibritin VIRAL PROTEIN 01/08/09 Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation Lama glama; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 lama glama severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Weckener, M., Naismith, J.H., Owens, R.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8oyt F NA 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 01/08/09 Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation Lama glama; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 lama glama severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Weckener, M., Naismith, J.H., Owens, R.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8s2e H L 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/08/09 Fab4251-DS-SOSIP complex HIV whole-genome vector AA1305#18; Homo sapiens homo sapiens homo sapiens hiv whole-genome vector aa1305#18 Nortier, P., Perez, L. 3.8 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8vy6 NA A 0 NA NA NA NA IMMUNE SYSTEM 07/03/24 Murine light chain dimer Mus musculus mus musculus Kapingidza, A.B., Dolamore, C., Hyduke, N.P., Easly, W., Chivv, C., Pomes, A., Chruszcz, M. 2.8 X-RAY DIFFRACTION 0.259 0.198 False True NA IGKV9 Kappa None None None None None 8vy6 NA B 0 NA NA NA NA IMMUNE SYSTEM 07/03/24 Murine light chain dimer Mus musculus mus musculus Kapingidza, A.B., Dolamore, C., Hyduke, N.P., Easly, W., Chivv, C., Pomes, A., Chruszcz, M. 2.8 X-RAY DIFFRACTION 0.259 0.198 False True NA IGKV9 Kappa None None None None None 8xio D NA 0 B | C protein | protein NA | NA g-alpha-i | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Structure of L797591-SSTR1 G protein complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Wang, Y., Xu, Y., Xu, H.E., Zhuang, Y. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xip D NA 0 B | C protein | protein NA | NA g-alpha i | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Structure of Pasireotide-SSTR1 G protein complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Wang, Y., Xu, Y., Xu, H.E., Zhuang, Y. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xiq D NA 0 B | C protein | protein NA | NA g-alpha i | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Structure of L796778-SSTR3 G protein complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Wang, Y., Xu, Y., Xu, H.E., Zhuang, Y. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xir D NA 0 B | C protein | protein NA | NA g-alpha i | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Structure of pasireotide-SSTR3 G protein complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Wang, Y., Xu, Y., Xu, H.E., Zhuang, Y. 2.52 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8y6a C D 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/03/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2 and S309 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, L.J., Gu, Y.H., Qi, J.X., Gao, G.F. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ytn A a 0 NA NA NA NA IMMUNE SYSTEM 07/03/24 Single-chain Fv antibody of E11 Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.72 X-RAY DIFFRACTION 0.213 0.185 True True unknown unknown unknown None None None None None 8yto A a 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Single-chain Fv antibody of E11 complex with NP-glycine Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.04 X-RAY DIFFRACTION 0.124 0.107 True True unknown unknown unknown None None None None None 8ytp A a 0 a Hapten LZO 5-(5-(3-hydroxyphenyl)thiophen-2-yl)pentanoic acid IMMUNE SYSTEM 01/08/09 Single-chain Fv antibody of E11 complex with NP-glycine under reducing conditions Mus musculus mus musculus Yoshida, M., Hanazono, Y., Numoto, N., Ito, N., Oda, M. 1.36 X-RAY DIFFRACTION 0.175 0.146 True True unknown unknown unknown None None None None None 8yzk C c 0 A protein NA soluble cytochrome b562,g-protein coupled receptor family cgroup 5 member d MEMBRANE PROTEIN 07/03/24 Orphan receptor GPRC5D in complex with scFv150-18 Escherichia coli; Homo sapiens homo sapiens escherichia coli, homo sapiens Yan, P., Lin, X., Xu, F. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yzk D d 0 B protein NA soluble cytochrome b562,g-protein coupled receptor family cgroup 5 member d MEMBRANE PROTEIN 07/03/24 Orphan receptor GPRC5D in complex with scFv150-18 Escherichia coli; Homo sapiens homo sapiens escherichia coli, homo sapiens Yan, P., Lin, X., Xu, F. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zh8 S s 0 A protein NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2,guanine nucleotide-binding protein g(i) subunit alpha-2, guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas MEMBRANE PROTEIN/IMMUNE SYSTEM 07/03/24 Human GPR103 -Gq complex bound to QRFP26 Bos taurus; Homo sapiens; Lama glama; Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus homo sapiens Iwama, A., Akasaka, H., Sano, F.K., Oshima, H.S., Shihoya, W., Nureki, O. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zh8 N NA 0 B protein NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/03/24 Human GPR103 -Gq complex bound to QRFP26 Bos taurus; Homo sapiens; Lama glama; Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama rattus norvegicus Iwama, A., Akasaka, H., Sano, F.K., Oshima, H.S., Shihoya, W., Nureki, O. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zjd S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/03/24 Cryo-EM structure of kisspeptin receptor bound to KP-10 Homo sapiens; Mus sp.; SYNTHETIC CONSTRUCT mus sp. homo sapiens | homo sapiens Shen, S., Liu, H., Xu, H.E. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zje S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/03/24 Cryo-EM structure of kisspeptin receptor bound to TAK-448 Homo sapiens; Mus sp.; SYNTHETIC CONSTRUCT mus sp. homo sapiens | homo sapiens Shen, S., Liu, H., Xu, H.E. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9at8 L K 0 F | E protein | peptide NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN 07/03/24 Fab 77-stabilized MeV F ectodomain fragment Homo sapiens; Measles morbillivirus homo sapiens homo sapiens measles morbillivirus | measles morbillivirus Zyla, D., Saphire, E.O. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV16 Kappa None None None None None 9en2 B NA 0 A protein NA procollagen c-endopeptidase enhancer 1 CELL ADHESION 07/03/24 Crystal structure of the metalloproteinase enhancer PCPE-1 complexed with nanobodies VHH-H4 and VHH-I5 Homo sapiens; Lama glama lama glama homo sapiens Lagoutte, P., Gueguen-Chaignon, V., Bourhis, J.-M., Vadon-Le Goff, S. 2.2 X-RAY DIFFRACTION 0.242 0.208 False True IGHV3 NA NA None None None None None 9en2 C NA 0 A protein NA procollagen c-endopeptidase enhancer 1 CELL ADHESION 07/03/24 Crystal structure of the metalloproteinase enhancer PCPE-1 complexed with nanobodies VHH-H4 and VHH-I5 Homo sapiens; Lama glama lama glama homo sapiens Lagoutte, P., Gueguen-Chaignon, V., Bourhis, J.-M., Vadon-Le Goff, S. 2.2 X-RAY DIFFRACTION 0.242 0.208 False True IGHV1 NA NA None None None None None 8txt H L 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 Crystal structure of 05.GC.w13.02 Fab in complex with H5 HA from A/Viet Nam/1203/2004(H5N1) Homo sapiens; Influenza A virus (A/Viet Nam/1203/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) | influenza a virus (a/viet nam/1203/2004(h5n1)) Lin, T.H., Moore, N., Wilson, I.A. 3.19 X-RAY DIFFRACTION 0.258 0.217 False True IGHV1 IGKV1 Kappa None None None None None 8txt G I 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 Crystal structure of 05.GC.w13.02 Fab in complex with H5 HA from A/Viet Nam/1203/2004(H5N1) Homo sapiens; Influenza A virus (A/Viet Nam/1203/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) | influenza a virus (a/viet nam/1203/2004(h5n1)) Lin, T.H., Moore, N., Wilson, I.A. 3.19 X-RAY DIFFRACTION 0.258 0.217 False True IGHV1 IGKV1 Kappa None None None None None 8txt J K 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 Crystal structure of 05.GC.w13.02 Fab in complex with H5 HA from A/Viet Nam/1203/2004(H5N1) Homo sapiens; Influenza A virus (A/Viet Nam/1203/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) | influenza a virus (a/viet nam/1203/2004(h5n1)) Lin, T.H., Moore, N., Wilson, I.A. 3.19 X-RAY DIFFRACTION 0.258 0.217 False True IGHV1 IGKV1 Kappa None None None None None 8u44 V X 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 CryoEM structure of A/Solomon Islands/3/2006 H1 HA in complex with 05.GC.w2.3C10-H1_SI06 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Moore, N., Han, J., Ward, A.B., Wilson, I.A. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8u44 S T 0 I | G protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 CryoEM structure of A/Solomon Islands/3/2006 H1 HA in complex with 05.GC.w2.3C10-H1_SI06 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Moore, N., Han, J., Ward, A.B., Wilson, I.A. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8u44 U W 0 J | H protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 CryoEM structure of A/Solomon Islands/3/2006 H1 HA in complex with 05.GC.w2.3C10-H1_SI06 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Moore, N., Han, J., Ward, A.B., Wilson, I.A. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7scn H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 08/24/22 Structure of H1 NC99 influenza hemagglutinin bound to Fab 310-63E6 Homo sapiens; Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) homo sapiens homo sapiens influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) | influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) Ward, A., Torrents de la Pena, A. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7scn E F 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 08/24/22 Structure of H1 NC99 influenza hemagglutinin bound to Fab 310-63E6 Homo sapiens; Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) homo sapiens homo sapiens influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) | influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) Ward, A., Torrents de la Pena, A. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7scn J K 0 I | G protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 08/24/22 Structure of H1 NC99 influenza hemagglutinin bound to Fab 310-63E6 Homo sapiens; Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) homo sapiens homo sapiens influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) | influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) Ward, A., Torrents de la Pena, A. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sco H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 08/24/22 Structure of H1 influenza hemagglutinin bound to Fab 310-39G10 Homo sapiens; Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) homo sapiens homo sapiens influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) | influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) Torrents de la Pena, A., Ward, A.B. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sco E F 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 08/24/22 Structure of H1 influenza hemagglutinin bound to Fab 310-39G10 Homo sapiens; Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) homo sapiens homo sapiens influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) | influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) Torrents de la Pena, A., Ward, A.B. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sco J K 0 I | G protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 08/24/22 Structure of H1 influenza hemagglutinin bound to Fab 310-39G10 Homo sapiens; Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) homo sapiens homo sapiens influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) | influenza a virus (strain a/new zealandcanterbury/35/2000 h1n1) Torrents de la Pena, A., Ward, A.B. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dk5 K k 0 G | F | E | H protein | protein | protein | protein NA | NA | NA | NA histone h2a type 2-c | histone h4 | histone h3.1 | histone h2b type 2-e TRANSCRIPTION/DNA 06/28/23 Structure of 187bp LIN28b nucleosome with site 0 mutation Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.71 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dk5 N n 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 2-c | histone h4 | histone h2b type 2-e TRANSCRIPTION/DNA 06/28/23 Structure of 187bp LIN28b nucleosome with site 0 mutation Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.71 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iqr H L 0 H Hapten HZA 2,5,8,11,14,17,20,23,26-nonaoxaoctacosane IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M9 Fv-clasp fragment with PEG (co-crystallization with PEG550DME) Mus musculus mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 2.35 X-RAY DIFFRACTION 0.292 0.235 False True IGHV5 IGKV1 Kappa None None None None None 8iqr h l 0 h Hapten HZA 2,5,8,11,14,17,20,23,26-nonaoxaoctacosane IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M9 Fv-clasp fragment with PEG (co-crystallization with PEG550DME) Mus musculus mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 2.35 X-RAY DIFFRACTION 0.292 0.235 False False IGHV5 IGKV1 Kappa None None None None None 7t0f H L 0 L Hapten K71 3-deoxy-4-O-methyl-alpha-D-manno-oct-2-ulopyranosonic acid IMMUNE SYSTEM 04/20/22 Crystal structure of S25-39 Fab in complex with 4-MeO-KdoOAll Mus musculus mus musculus mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2 X-RAY DIFFRACTION 0.261 0.214 False True IGHV7 IGKV8 Kappa None None None None None 7uib B NA 0 A protein NA neurotoxin type e TOXIN 04/05/23 Crystal structure of BoNT/E receptor binding domain in complex with SV2, VHH, and sialic acid Clostridium botulinum; Homo sapiens; Vicugna pacos vicugna pacos clostridium botulinum Liu, Z., Jin, R., Chen, P. 2.77 X-RAY DIFFRACTION 0.261 0.235 False True IGHV1 NA NA None None None None None 7uib E NA 0 D protein NA neurotoxin type e TOXIN 04/05/23 Crystal structure of BoNT/E receptor binding domain in complex with SV2, VHH, and sialic acid Clostridium botulinum; Homo sapiens; Vicugna pacos vicugna pacos clostridium botulinum Liu, Z., Jin, R., Chen, P. 2.77 X-RAY DIFFRACTION 0.261 0.235 False True IGHV1 NA NA None None None None None 7uie B NA 0 A protein NA botulinum neurotoxin e heavy chain ANTITOXIN/TOXIN 04/05/23 Crystal structure of HcE-JLE-G6 Clostridium botulinum; Vicugna pacos vicugna pacos clostridium botulinum Jin, R., Lam, K. 3.23 X-RAY DIFFRACTION 0.273 0.230 False True IGHV1 NA NA None None None None None 7uie C NA 0 D protein NA botulinum neurotoxin e heavy chain ANTITOXIN/TOXIN 04/05/23 Crystal structure of HcE-JLE-G6 Clostridium botulinum; Vicugna pacos vicugna pacos clostridium botulinum Jin, R., Lam, K. 3.23 X-RAY DIFFRACTION 0.273 0.230 False True IGHV1 NA NA None None None None None 7uie E NA 0 F protein NA botulinum neurotoxin e heavy chain ANTITOXIN/TOXIN 04/05/23 Crystal structure of HcE-JLE-G6 Clostridium botulinum; Vicugna pacos vicugna pacos clostridium botulinum Jin, R., Lam, K. 3.23 X-RAY DIFFRACTION 0.273 0.230 False True IGHV1 NA NA None None None None None 7uie I NA 0 J protein NA botulinum neurotoxin e heavy chain ANTITOXIN/TOXIN 04/05/23 Crystal structure of HcE-JLE-G6 Clostridium botulinum; Vicugna pacos vicugna pacos clostridium botulinum Jin, R., Lam, K. 3.23 X-RAY DIFFRACTION 0.273 0.230 False True IGHV1 NA NA None None None None None 7uie G NA 0 H protein NA botulinum neurotoxin e heavy chain ANTITOXIN/TOXIN 04/05/23 Crystal structure of HcE-JLE-G6 Clostridium botulinum; Vicugna pacos vicugna pacos clostridium botulinum Jin, R., Lam, K. 3.23 X-RAY DIFFRACTION 0.273 0.230 False True IGHV1 NA NA None None None None None 7uij H L 0 C protein NA outer surface protein c IMMUNE SYSTEM 04/05/23 Structural studies of B5-OspC complex Borreliella burgdorferi B31; Mus musculus mus musculus mus musculus borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 2.701 X-RAY DIFFRACTION 0.256 0.204 False True IGHV9 IGKV12 Kappa None None None None None 7uij A B 0 D protein NA outer surface protein c IMMUNE SYSTEM 04/05/23 Structural studies of B5-OspC complex Borreliella burgdorferi B31; Mus musculus mus musculus mus musculus borreliella burgdorferi b31 Rudolph, M.J., Mantis, N. 2.701 X-RAY DIFFRACTION 0.256 0.204 False True IGHV9 IGKV12 Kappa None None None None None 8av2 C NA 0 A protein NA leptin receptor CYTOKINE 04/05/23 Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80 Lama glama; Mus musculus lama glama mus musculus Verstraete, K., Savvides, S.N., Verschueren, K.G., Tsirigotaki, A. 1.75 X-RAY DIFFRACTION 0.233 0.193 False True IGHV1 NA NA None None None None None 8av2 D NA 0 B protein NA leptin receptor CYTOKINE 04/05/23 Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80 Lama glama; Mus musculus lama glama mus musculus Verstraete, K., Savvides, S.N., Verschueren, K.G., Tsirigotaki, A. 1.75 X-RAY DIFFRACTION 0.233 0.193 False True IGHV1 NA NA None None None None None 8dbz D E 0 A protein NA glycoprotein n VIRAL PROTEIN/IMMUNE SYSTEM 04/05/23 CryoEM structure of Hantavirus ANDV Gn(H) protein complex with 2Fabs ANDV-5 and ANDV-34 Andes orthohantavirus; Homo sapiens homo sapiens homo sapiens andes orthohantavirus Binshtein, E., Crowe, J.E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dbz B C 0 A protein NA glycoprotein n VIRAL PROTEIN/IMMUNE SYSTEM 04/05/23 CryoEM structure of Hantavirus ANDV Gn(H) protein complex with 2Fabs ANDV-5 and ANDV-34 Andes orthohantavirus; Homo sapiens homo sapiens homo sapiens andes orthohantavirus Binshtein, E., Crowe, J.E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8dcn A B 0 C protein NA adp-ribosylating binary toxin binding subunit cdtb TOXIN/IMMUNE SYSTEM 04/05/23 Crystal structure of Clostridioides difficile binary toxin CDTb D4 fragment in complex with BINTOXB/9 Fab Clostridioides difficile; Mus musculus mus musculus mus musculus clostridioides difficile Goldsmith, J.A., McLellan, J.S. 2.6 X-RAY DIFFRACTION 0.260 0.227 False True IGHV1 IGKV8 Kappa None None None None None 8dcn D E 0 F protein NA adp-ribosylating binary toxin binding subunit cdtb TOXIN/IMMUNE SYSTEM 04/05/23 Crystal structure of Clostridioides difficile binary toxin CDTb D4 fragment in complex with BINTOXB/9 Fab Clostridioides difficile; Mus musculus mus musculus mus musculus clostridioides difficile Goldsmith, J.A., McLellan, J.S. 2.6 X-RAY DIFFRACTION 0.260 0.227 False True IGHV1 IGKV8 Kappa None None None None None 8gjm D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 01/08/09 17b10 fab in complex with full-length SARS-CoV-2 Spike G614 trimer Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Kwon, H.J., Zhang, J., Kosikova, M., Tang, W.C., Rodriguez, U.O., Peng, H.Q., Meseda, C.A., Pedro, C.L., Schmeisser, F., Lu, J.M., Zhou, B., Davis, C.T., Wentworth, D.E., Chen, W.H., Shriver, M.C., Pasetti, M.F., Weir, J.P., Chen, B., Xie, H. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV9 Kappa None None None None None 8gjn A B 0 C protein NA spike protein s2' VIRAL PROTEIN 04/05/23 17B10 fab in complex with up-RBD of SARS-CoV-2 Spike G614 trimer Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Kwon, H.J., Zhang, J., Kosikova, M., Tang, W.C., Rodriguez, U.O., Peng, H.Q., Meseda, C.A., Pedro, C.L., Schmeisser, F., Lu, J.M., Zhou, B., Davis, C.T., Wentworth, D.E., Chen, W.H., Shriver, M.C., Pasetti, M.F., Weir, J.P., Chen, B., Xie, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV9 Kappa None None None None None 8gv0 A B 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FIXa IgG fab without FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 3.192 X-RAY DIFFRACTION 0.310 0.196 False True IGHV3 IGKV3 Kappa None None None None None 8gv0 C D 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FIXa IgG fab without FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 3.192 X-RAY DIFFRACTION 0.310 0.196 False True IGHV3 IGKV3 Kappa None None None None None 8gv0 E F 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FIXa IgG fab without FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 3.192 X-RAY DIFFRACTION 0.310 0.196 False True IGHV3 IGKV3 Kappa None None None None None 8gv0 G H 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FIXa IgG fab without FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 3.192 X-RAY DIFFRACTION 0.310 0.196 False True IGHV3 IGKV3 Kappa None None None None None 8gv2 A B 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FX IgG fab without FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 1.274 X-RAY DIFFRACTION 0.215 0.195 False True IGHV1 IGLV3 Lambda None None None None None 8ghk H L 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 CryoEM structure of Influenza A virus A/Melbourner/1/1946 (H1N1) hemagglutinin bound to GS10-X6-BE4 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.47 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 8ghk M N 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 CryoEM structure of Influenza A virus A/Melbourner/1/1946 (H1N1) hemagglutinin bound to GS10-X6-BE4 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.47 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV10 Kappa None None None None None 8gjr A NA 0 C protein NA cftr inhibitory factor IMMUNE SYSTEM 06/26/24 Crystal Structure of Nanobody VHH114 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 1.85 X-RAY DIFFRACTION 0.192 0.170 False True IGHV1 NA NA None None None None None 8k4q B NA 0 A protein NA interleukin-4 receptor subunit alpha CYTOKINE 06/26/24 Crystal structure of nanobody HuNb103 bound to human interleukin-4 receptor subunit alpha Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Ding, Y., Zhong, P.Y. 2.59 X-RAY DIFFRACTION 0.280 0.222 False True IGHV3 NA NA None None None None None 8k4q D NA 0 C protein NA interleukin-4 receptor subunit alpha CYTOKINE 06/26/24 Crystal structure of nanobody HuNb103 bound to human interleukin-4 receptor subunit alpha Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Ding, Y., Zhong, P.Y. 2.59 X-RAY DIFFRACTION 0.280 0.222 False True IGHV3 NA NA None None None None None 8s0l B NA 0 A protein NA transmembrane protease serine 2 PROTEASE/NANOBODY INHIBITOR 06/26/24 Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Duquerroy, S., Fernandez, I., Rey, F. 1.8 X-RAY DIFFRACTION 0.215 0.177 False True IGHV1 NA NA None None None None None 8s0m U NA 0 B protein NA transmembrane protease serine 2 VIRAL PROTEIN/RECEPTOR 06/26/24 Crystal structure of the HKU1 receptor binding domain in complex with TMPRSS2 and the nanobody A01 Homo sapiens; Human coronavirus HKU1 (isolate N5); Vicugna pacos vicugna pacos homo sapiens Duquerroy, S., Fernandez, I., Rey, F. 3.55 X-RAY DIFFRACTION 0.221 0.193 False True IGHV1 NA NA None None None None None 8s0m V NA 0 E protein NA transmembrane protease serine 2 VIRAL PROTEIN/RECEPTOR 06/26/24 Crystal structure of the HKU1 receptor binding domain in complex with TMPRSS2 and the nanobody A01 Homo sapiens; Human coronavirus HKU1 (isolate N5); Vicugna pacos vicugna pacos homo sapiens Duquerroy, S., Fernandez, I., Rey, F. 3.55 X-RAY DIFFRACTION 0.221 0.193 False True IGHV1 NA NA None None None None None 8s0n B NA 0 A protein NA transmembrane protease serine 2 PROTEASE/NANOBODY INHIBITOR 06/26/24 Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Duquerroy, S., Fernandez, I., Rey, F. 2.3 X-RAY DIFFRACTION 0.246 0.211 False True IGHV1 NA NA None None None None None 8s0n D NA 0 C protein NA transmembrane protease serine 2 PROTEASE/NANOBODY INHIBITOR 06/26/24 Crystal structure of the TMPRSS2 zymogen in complex with the nanobody A07 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Duquerroy, S., Fernandez, I., Rey, F. 2.3 X-RAY DIFFRACTION 0.246 0.211 False True IGHV1 NA NA None None None None None 8s6e A B 0 NA NA NA NA IMMUNE SYSTEM 06/26/24 Monoclonal antibody MenW targeting serogroup W of Neisseria meningitidis Mus musculus mus musculus mus musculus Pietri, G.P., Bertuzzi, S., Karnicar, K., Unione, L., Lisnic, B., Malic, S., Miklic, K., Novak, M., Calloni, I., Santini, L., Usenik, A., Rosaria Romano, M., Adamo, R., Jonjic, S., Turk, D., Jimenez-Barbero, J., Lenac Rovis, T. 1.95 X-RAY DIFFRACTION 0.223 0.201 False True IGHV1 IGKV9 Kappa None None None None None 8tv1 D E 0 C protein NA ephrin type-a receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 06/26/24 Structure of the EphA2 LBDCRD bound to FabS1C_L1 Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 2.6 X-RAY DIFFRACTION 0.246 0.202 False True IGHV3 IGKV1 Kappa None None None None None 8txm H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 Crystal structure of 05.GC.w13.02 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus (strain swl A/California/04/2009 H1N1) homo sapiens homo sapiens influenza a virus (strain swla/california/04/2009 h1n1) | influenza a virus (strain swla/california/04/2009 h1n1) Lin, T.H., Moore, N., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.287 0.275 False True IGHV1 IGKV1 Kappa None None None None None 8txp H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 Crystal structure of 05.GC.w13.01 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Lin, T.H., Moore, N., Wilson, I.A. 2.75 X-RAY DIFFRACTION 0.292 0.250 False True IGHV1 IGKV1 Kappa None None None None None 8ty7 H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/26/24 Crystal structure of 05.GC.w2.3C10 Fab in complex with H1 HA from A/California/04/2009(H1N1) Homo sapiens; Influenza A virus (strain swl A/California/04/2009 H1N1) homo sapiens homo sapiens influenza a virus (strain swla/california/04/2009 h1n1) | influenza a virus (strain swla/california/04/2009 h1n1) Lin, T.H., Moore, N., Wilson, I.A. 3.21 X-RAY DIFFRACTION 0.288 0.245 False True IGHV1 IGKV1 Kappa None None None None None 8vqy J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chojnacka, W., Teng, J., Kim, J.J., Jensen, A.A., Hibbs, R.E. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8vqy K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chojnacka, W., Teng, J., Kim, J.J., Jensen, A.A., Hibbs, R.E. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8vrn J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chojnacka, W., Teng, J., Kim, J.J., Jensen, A.A., Hibbs, R.E. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8vrn K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chojnacka, W., Teng, J., Kim, J.J., Jensen, A.A., Hibbs, R.E. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 9b70 G NA 0 A protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase TRANSFERASE 01/08/09 Cryo-EM structure of MraY in complex with analogue 2 Aquifex aeolicus VF5; Lama glama lama glama aquifex aeolicus vf5 Hao, A., Lee, S.-Y. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9b70 H NA 0 B protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase TRANSFERASE 01/08/09 Cryo-EM structure of MraY in complex with analogue 2 Aquifex aeolicus VF5; Lama glama lama glama aquifex aeolicus vf5 Hao, A., Lee, S.-Y. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9b71 H NA 0 B protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase TRANSFERASE 01/08/09 Cryo-EM structure of MraY in complex with analogue 3 Aquifex aeolicus VF5; Lama glama lama glama aquifex aeolicus vf5 Hao, A., Lee, S.-Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9b71 G NA 0 A protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase TRANSFERASE 01/08/09 Cryo-EM structure of MraY in complex with analogue 3 Aquifex aeolicus VF5; Lama glama lama glama aquifex aeolicus vf5 Hao, A., Lee, S.-Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 9erx F f 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Thorsen, T.S., Kulkarni, Y., Boggild, A., Drace, T., Nissen, P., Gajhede, M., Boesen, T., Kastrup, J.S., Gloriam, D. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yj7 G g 0 B protein NA iron abc transporter substrate-binding lipoprotein mtsa METAL TRNASPORT/IMMUNE SYSTEM 06/19/24 Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA Oryctolagus cuniculus; Streptococcus pyogenes oryctolagus cuniculus streptococcus pyogenes Ito, S., Nagatoishi, S., Nakakido, M., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.276 0.222 True True unknown unknown unknown None None None None None 8yj7 E e 0 C protein NA iron abc transporter substrate-binding lipoprotein mtsa METAL TRNASPORT/IMMUNE SYSTEM 06/19/24 Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA Oryctolagus cuniculus; Streptococcus pyogenes oryctolagus cuniculus streptococcus pyogenes Ito, S., Nagatoishi, S., Nakakido, M., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.276 0.222 True True unknown unknown unknown None None None None None 8yj7 F f 0 B protein NA iron abc transporter substrate-binding lipoprotein mtsa METAL TRNASPORT/IMMUNE SYSTEM 06/19/24 Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA Oryctolagus cuniculus; Streptococcus pyogenes oryctolagus cuniculus streptococcus pyogenes Ito, S., Nagatoishi, S., Nakakido, M., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.276 0.222 True True unknown unknown unknown None None None None None 8yj7 H h 0 A protein NA iron abc transporter substrate-binding lipoprotein mtsa METAL TRNASPORT/IMMUNE SYSTEM 06/19/24 Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA Oryctolagus cuniculus; Streptococcus pyogenes oryctolagus cuniculus streptococcus pyogenes Ito, S., Nagatoishi, S., Nakakido, M., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.276 0.222 True True unknown unknown unknown None None None None None 8rmm L NA 0 A protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm M NA 0 B protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm O NA 0 E protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm P NA 0 F protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm Q NA 0 G protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm R NA 0 H protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm S NA 0 I protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm T NA 0 I protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm U NA 0 K protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmm N NA 0 D | C protein | protein NA | NA calcium homeostasis modulator protein 2 | calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Drozdzyk, K., Dutzler, R. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c0y B D 0 A protein NA spike protein s2' VIRAL PROTEIN 06/19/24 SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Das, H., Hallberg, B.M. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8jr3 A D 0 F protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 06/19/24 Crystal structure of Hendra Virus attachment(G) glycoprotein mutant S586N in complex with neutralizing antibody 14F8 Hendra virus (isolate Horse/Autralia/Hendra/1994); Mus musculus mus musculus mus musculus hendra virus (isolatehorse/autralia/hendra/1994) Li, Y.H., Huang, X.Y., Xu, J.J., Chen, W. 3.22 X-RAY DIFFRACTION 0.241 0.216 False True IGHV2 IGKV1 Kappa None None None None None 8jr3 B C 0 E protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 06/19/24 Crystal structure of Hendra Virus attachment(G) glycoprotein mutant S586N in complex with neutralizing antibody 14F8 Hendra virus (isolate Horse/Autralia/Hendra/1994); Mus musculus mus musculus mus musculus hendra virus (isolatehorse/autralia/hendra/1994) Li, Y.H., Huang, X.Y., Xu, J.J., Chen, W. 3.22 X-RAY DIFFRACTION 0.241 0.216 False True IGHV2 IGKV1 Kappa None None None None None 8kg5 D E 0 C | B protein | protein NA | NA fusion glycoprotein f0,fibritin | fusion glycoprotein f0,fibritin VIRAL PROTEIN/IMMUNE SYSTEM 06/19/24 Prefusion RSV F Bound to Lonafarnib and D25 Fab Enterobacteria phage T4; Homo sapiens; Human respiratory syncytial virus A (strain A2) homo sapiens homo sapiens human respiratory syncytial virus a (straina2), enterobacteria phage t4 | human respiratory syncytial virus a (straina2), enterobacteria phage t4 Yang, Q., Xue, B., Liu, F., Peng, W., Chen, X. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8khr H L 0 C | A | B protein | protein | protein NA | NA | NA soluble gp42 | envelope glycoprotein h | envelope glycoprotein l VIRAL PROTEIN/IMMUNE SYSTEM 06/19/24 Cryo-EM structure of EBV gH/gL-gp42 in complex with fab 2C1 Epstein-Barr virus (strain GD1); Homo sapiens homo sapiens homo sapiens epstein-barr virus (strain gd1) | epstein-barr virus (strain gd1) | epstein-barr virus (strain gd1) Fang, X.Y., Zhao, G.X., Zeng, M.S., Liu, Z. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8pe1 C NA 0 A protein NA 1,3-beta-glucanosyltransferase TRANSFERASE 06/19/24 Crystal structure of Gel4 in complex with Nanobody 4 Aspergillus fumigatus Af293; Vicugna pacos vicugna pacos aspergillus fumigatus af293 Macias-Leon, J., Redrado-Hernandez, S., Castro-Lopez, J., Sanz, A.B., Arias, M., Farkas, V., Vincke, C., Muyldermans, S., Pardo, J., Arroyo, J., Galvez, E., Hurtado-Guerrero, R. 1.9 X-RAY DIFFRACTION 0.264 0.215 False True unknown unknown unknown None None None None None 8pe1 D NA 0 B protein NA 1,3-beta-glucanosyltransferase TRANSFERASE 06/19/24 Crystal structure of Gel4 in complex with Nanobody 4 Aspergillus fumigatus Af293; Vicugna pacos vicugna pacos aspergillus fumigatus af293 Macias-Leon, J., Redrado-Hernandez, S., Castro-Lopez, J., Sanz, A.B., Arias, M., Farkas, V., Vincke, C., Muyldermans, S., Pardo, J., Arroyo, J., Galvez, E., Hurtado-Guerrero, R. 1.9 X-RAY DIFFRACTION 0.264 0.215 False True unknown unknown unknown None None None None None 8pe2 B NA 0 A protein NA 1,3-beta-glucanosyltransferase TRANSFERASE 06/19/24 Crystal structure of Gel4 in complex with Nanobody 3 Aspergillus fumigatus; Vicugna pacos vicugna pacos aspergillus fumigatus Macias-Leon, J., Redrado-Hernandez, S., Castro-Lopez, J., Sanz, A.B., Arias, M., Farkas, V., Vincke, C., Muyldermans, S., Pardo, J., Arroyo, J., Galvez, E., Hurtado-Guerrero, R. 2.05 X-RAY DIFFRACTION 0.206 0.172 False True IGHV1 NA NA None None None None None 8qh0 H L 0 A protein NA spike protein s1 VIRAL PROTEIN 06/19/24 Crystal structure of the SARS-CoV-2 RBD with the antibody Cv2.3194 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fernandez, I., Rey, F.A. 1.87 X-RAY DIFFRACTION 0.209 0.185 False True IGHV3 IGKV3 Kappa None None None None None 8qh1 H L 0 E protein NA spike glycoprotein VIRAL PROTEIN 06/19/24 Crystal structure of the SARS-CoV-2 RBD from the Omicron BA4 variant with the antibody Cv2.3194 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fernandez, I., Rey, F.A. 2.65 X-RAY DIFFRACTION 0.232 0.198 False True IGHV3 IGKV3 Kappa None None None None None 8rgz D E 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. Homo sapiens; Human alphaherpesvirus 1 strain F homo sapiens homo sapiens human alphaherpesvirus 1 strain f Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8rgz H L 0 B protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. Homo sapiens; Human alphaherpesvirus 1 strain F homo sapiens homo sapiens human alphaherpesvirus 1 strain f Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8rgz F G 0 C protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. Homo sapiens; Human alphaherpesvirus 1 strain F homo sapiens homo sapiens human alphaherpesvirus 1 strain f Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8rh0 H L 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. Homo sapiens; Human alphaherpesvirus 1 homo sapiens homo sapiens human alphaherpesvirus 1 Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8rh0 D E 0 B protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. Homo sapiens; Human alphaherpesvirus 1 homo sapiens homo sapiens human alphaherpesvirus 1 Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8rh0 F G 0 C protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-1F gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. Homo sapiens; Human alphaherpesvirus 1 homo sapiens homo sapiens human alphaherpesvirus 1 Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8rh1 D E 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-2F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. Homo sapiens; Human herpesvirus 2 strain G homo sapiens homo sapiens human herpesvirus 2 strain g Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8rh1 H L 0 B protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-2F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. Homo sapiens; Human herpesvirus 2 strain G homo sapiens homo sapiens human herpesvirus 2 strain g Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8rh1 F G 0 C protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-2F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules. Homo sapiens; Human herpesvirus 2 strain G homo sapiens homo sapiens human herpesvirus 2 strain g Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 8rh2 H L 0 B protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-2G gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. Homo sapiens; Human herpesvirus 2 strain G homo sapiens homo sapiens human herpesvirus 2 strain g Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8rh2 D E 0 C protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-2G gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. Homo sapiens; Human herpesvirus 2 strain G homo sapiens homo sapiens human herpesvirus 2 strain g Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8rh2 F G 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 06/19/24 Trimeric HSV-2G gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. Homo sapiens; Human herpesvirus 2 strain G homo sapiens homo sapiens human herpesvirus 2 strain g Kalbermatter, D., Seyfizadeh, N., Imhof, T., Ries, M., Mueller, C., Jenner, L., Blumenschein, E., Yendrzheyevskiy, A., Moog, K., Eckert, D., Engel, R., Diebolder, P., Chami, M., Krauss, J., Schaller, T., Arndt, M. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8rmk L NA 0 B protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk M NA 0 C protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk N NA 0 D protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk O NA 0 E protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk P NA 0 F protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk Q NA 0 G protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk R NA 0 H protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk S NA 0 I protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk T NA 0 J protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk U NA 0 K protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmk V NA 0 A protein NA calcium homeostasis modulator protein 2 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rml L NA 0 A protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rml M NA 0 B protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Drozdzyk, K., Dutzler, R. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmn U NA 0 A protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmn V NA 0 B protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmn W NA 0 C protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmn X NA 0 D protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmn Y NA 0 E protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmn Z NA 0 F protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rmn a NA 0 G protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn b NA 0 H protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn c NA 0 I protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn d NA 0 J protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn e NA 0 K protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn f NA 0 L protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn g NA 0 M protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn h NA 0 N protein NA synthetic nanobody sbc4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn i NA 0 O protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn j NA 0 P protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn k NA 0 Q protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn l NA 0 R protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn m NA 0 S protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rmn n NA 0 T protein NA calcium homeostasis modulator protein 4 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4 Homo sapiens; synthetic construct synthetic construct homo sapiens Peter, M., Drozdzyk, K., Dutzler, R. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8rp8 A B 0 C protein NA leukocyte surface antigen cd47 IMMUNE SYSTEM 06/19/24 Structure of K2 Fab in complex with human CD47 ECD Homo sapiens homo sapiens homo sapiens homo sapiens Laursen, M., Kelpsas, V., Rose, N. 2 X-RAY DIFFRACTION 0.214 0.180 False True IGHV3 IGKV1 Kappa None None None None None 8rp8 H L 0 D protein NA leukocyte surface antigen cd47 IMMUNE SYSTEM 06/19/24 Structure of K2 Fab in complex with human CD47 ECD Homo sapiens homo sapiens homo sapiens homo sapiens Laursen, M., Kelpsas, V., Rose, N. 2 X-RAY DIFFRACTION 0.214 0.180 False True IGHV3 IGKV1 Kappa None None None None None 8rpb H L 0 P protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 06/19/24 Structure of S79 Fab in complex with IgV domain of human PD-L1 Homo sapiens homo sapiens homo sapiens homo sapiens Svensson, A., Kelpsas, V., Laursen, M., Rose, N. 2.794 X-RAY DIFFRACTION 0.251 0.229 False True IGHV3 IGLV2 Lambda None None None None None 8t51 A B 0 E peptide NA triggering receptor expressed on myeloid cells 2 peptide PEPTIDE BINDING PROTEIN 06/19/24 Crystal structure of Fab 3.10C2 bound to TREM2 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Hsu, P.L., Wallweber, H. 1.9 X-RAY DIFFRACTION 0.240 0.193 False True IGHV3 IGKV2 Kappa None None None None None 8t51 C D 0 F peptide NA triggering receptor expressed on myeloid cells 2 peptide PEPTIDE BINDING PROTEIN 06/19/24 Crystal structure of Fab 3.10C2 bound to TREM2 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Hsu, P.L., Wallweber, H. 1.9 X-RAY DIFFRACTION 0.240 0.193 False True IGHV3 IGKV2 Kappa None None None None None 8tr3 H L 0 A protein NA cne40 sosip envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 06/19/24 Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 3.74 ELECTRON MICROSCOPY NA NA True True IGHV1 IGKV1 Kappa None None None None None 8tr3 I M 0 C protein NA cne40 sosip envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 06/19/24 Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 3.74 ELECTRON MICROSCOPY NA NA True True IGHV1 IGKV1 Kappa None None None None None 8tr3 J N 0 E protein NA cne40 sosip envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 06/19/24 Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 3.74 ELECTRON MICROSCOPY NA NA True True IGHV1 IGKV1 Kappa None None None None None 8ts0 H L 0 A protein NA asialoglycoprotein receptor 1 SUGAR BINDING PROTEIN/IMMUNE SYSTEM 06/19/24 Crystal Structure of human ASGR1 CRD (Carbohydrate Recognition Domain) bound to 8M24 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Sampathkumar, P., Li, Y. 1.7 X-RAY DIFFRACTION 0.205 0.173 False True IGHV1 IGKV1 Kappa None None None None None 8u31 C B 0 A protein NA programmed cell death protein 1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 06/19/24 Crystal structure of PD-1 in complex with a Fab Homo sapiens homo sapiens homo sapiens homo sapiens Sun, D., Masureel, M. 2.73 X-RAY DIFFRACTION 0.238 0.199 False True IGHV3 IGKV1 Kappa None None None None None 8u32 C B 0 A protein NA programmed cell death protein 1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 06/19/24 Crystal structure of PD-1 in complex with a Fab Homo sapiens homo sapiens homo sapiens homo sapiens Sun, D., Masureel, M. 2.51 X-RAY DIFFRACTION 0.230 0.195 False True IGHV3 IGKV1 Kappa None None None None None 8u32 F E 0 D protein NA programmed cell death protein 1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 06/19/24 Crystal structure of PD-1 in complex with a Fab Homo sapiens homo sapiens homo sapiens homo sapiens Sun, D., Masureel, M. 2.51 X-RAY DIFFRACTION 0.230 0.195 False True IGHV3 IGKV1 Kappa None None None None None 8ukv C NA 0 A protein NA epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 06/19/24 Crystal structure of nanobody/VHH domain of 34E5 in complex with the extracellular region of the epidermal growth factor variant III (EGFRvIII) Homo sapiens; Lama glama lama glama homo sapiens Stayrook, S.E., Ferguson, K.M., Bagchi, A. 2.94 X-RAY DIFFRACTION 0.252 0.215 False True IGHV1 NA NA None None None None None 8ukv D NA 0 B protein NA epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 06/19/24 Crystal structure of nanobody/VHH domain of 34E5 in complex with the extracellular region of the epidermal growth factor variant III (EGFRvIII) Homo sapiens; Lama glama lama glama homo sapiens Stayrook, S.E., Ferguson, K.M., Bagchi, A. 2.94 X-RAY DIFFRACTION 0.252 0.215 False True IGHV1 NA NA None None None None None 8urf H L 0 A protein NA asialoglycoprotein receptor 2 SUGAR BINDING PROTEIN 06/19/24 Crystal Structure of human ASGR2 CRD (Carbohydrate Recognition Domain) bound to 8G8 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Sampathumar, P., Li, Y. 1.9 X-RAY DIFFRACTION 0.204 0.166 False True IGHV1 IGKV12 Kappa None None None None None 8v5a Y NA 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Prefusion-stabilized Respirovirus type 3 Fusion protein Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5a W NA 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Prefusion-stabilized Respirovirus type 3 Fusion protein Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5a U NA 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Prefusion-stabilized Respirovirus type 3 Fusion protein Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8vk1 F E 0 D protein NA der p 2 variant 3 ALLERGEN/IMMUNE SYSTEM 06/19/24 X-ray crystal structure of human IgE 4C8 Fab complex with Der p 2.0103 Dermatophagoides pteronyssinus; Homo sapiens homo sapiens homo sapiens dermatophagoides pteronyssinus Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 3.05 X-RAY DIFFRACTION 0.248 0.197 False True IGHV3 IGLV3 Lambda None None None None None 8vk1 C B 0 A protein NA der p 2 variant 3 ALLERGEN/IMMUNE SYSTEM 06/19/24 X-ray crystal structure of human IgE 4C8 Fab complex with Der p 2.0103 Dermatophagoides pteronyssinus; Homo sapiens homo sapiens homo sapiens dermatophagoides pteronyssinus Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 3.05 X-RAY DIFFRACTION 0.248 0.197 False True IGHV3 IGLV3 Lambda None None None None None 8vk2 F E 0 NA NA NA NA IMMUNE SYSTEM 06/19/24 X-ray crystal structure of human IgE 4C8 Fab Homo sapiens homo sapiens homo sapiens Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 2.508 X-RAY DIFFRACTION 0.247 0.198 False True IGHV3 IGLV3 Lambda None None None None None 8vk2 C B 0 NA NA NA NA IMMUNE SYSTEM 06/19/24 X-ray crystal structure of human IgE 4C8 Fab Homo sapiens homo sapiens homo sapiens Khatri, K., Ball, A., Smith, S.A., Champan, M.D., Pomes, A., Chruszcz, M. 2.508 X-RAY DIFFRACTION 0.247 0.198 False True IGHV3 IGLV3 Lambda None None None None None 8wss H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, L., He, Q., Yuan, Q., Gu, Y., Shan, H., Hu, W., Wu, K., Xu, H.E., Zhang, Y., Wu, C. 3.01 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wst N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/19/24 Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH Homo sapiens homo sapiens homo sapiens | homo sapiens Zhao, L., He, Q., Yuan, Q., Gu, Y., Shan, H., Hu, W., Wu, K., Xu, H.E., Zhang, Y., Wu, C. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8wz2 E e 0 A | B protein | protein NA | NA g-alpha q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/19/24 Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex Bos taurus; Homo sapiens; Rattus norvegicus homo sapiens homo sapiens | rattus norvegicus Jin, S., Li, X., Xu, Y., Guo, S., Wu, C., Zhang, H., Yuan, Q., Xu, H.E., Xie, X., Jiang, Y. 2.73 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xbf D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/19/24 Cryo-EM structure of SARS-CoV-2 S-BQ.1 in complex with antibody O5C2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hsu, H.F., Wu, M.H., Chang, Y.C., Hsu, S.T.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xbf F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 06/19/24 Cryo-EM structure of SARS-CoV-2 S-BQ.1 in complex with antibody O5C2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hsu, H.F., Wu, M.H., Chang, Y.C., Hsu, S.T.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xbf NA G 0 NA NA NA NA VIRAL PROTEIN 06/19/24 Cryo-EM structure of SARS-CoV-2 S-BQ.1 in complex with antibody O5C2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens Hsu, H.F., Wu, M.H., Chang, Y.C., Hsu, S.T.D. 3.6 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 8xxw H L 0 E protein NA spike protein s1 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 06/19/24 Fab M2-7 complexed with SARS-Cov2 RBD and human ACE2 Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Liu, C., Xie, Y. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV14 Kappa None None None None None 8yj5 C NA 0 A protein NA iron abc transporter substrate-binding lipoprotein mtsa METAL TRANSPORT/IMMUNE SYSTEM 06/19/24 Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA Streptococcus pyogenes; Vicugna pacos vicugna pacos streptococcus pyogenes Ito, S., Nagatoishi, S., Nakakido, M., Tsumoto, K. 3.66 X-RAY DIFFRACTION 0.303 0.263 True True IGHV1 NA NA None None None None None 8yj8 C NA 0 NA NA NA NA METAL TRANSPORT/IMMUNE SYSTEM 06/19/24 Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA Streptococcus pyogenes; Vicugna pacos vicugna pacos Ito, S., Nagatoishi, S., Nakakido, M., Tsumoto, K. 1.65 X-RAY DIFFRACTION 0.228 0.188 True True IGHV1 NA NA None None None None None 8yj8 D NA 0 B protein NA iron abc transporter substrate-binding lipoprotein mtsa METAL TRANSPORT/IMMUNE SYSTEM 06/19/24 Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA Streptococcus pyogenes; Vicugna pacos vicugna pacos streptococcus pyogenes Ito, S., Nagatoishi, S., Nakakido, M., Tsumoto, K. 1.65 X-RAY DIFFRACTION 0.228 0.188 True True IGHV1 NA NA None None None None None 8zr5 N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Cryo-EM Structure of GPR119-Gs-Firuglipel complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Wong, T.S., Zeng, Z.C., Xiong, T.T., Gan, S.Y., Qiu, C., Du, Y. 3.31 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8zrk N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Wong, T.S., Xiong, T.T., Zeng, Z.C., Gan, S.Y., Qiu, C., Du, Y. 2.82 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jiz E F 0 B protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation Homo sapiens homo sapiens homo sapiens homo sapiens Wang, H., Zhu, S. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jiz G H 0 D | A protein | protein NA | NA glutamate receptor ionotropic, nmda 1 | glutamate receptor ionotropic, nmda 2a MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Wang, H., Zhu, S. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8yz5 G K 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 SARS-CoV-2 Delta Spike in complex with Fab of JE-5C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 3.93 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8yz5 I J 0 C | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 SARS-CoV-2 Delta Spike in complex with Fab of JE-5C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 3.93 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hlc H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/05/24 S protein of SARS-CoV-2 in complex with 3711 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Y.Y., Guo, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hlc I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 06/05/24 S protein of SARS-CoV-2 in complex with 3711 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Y.Y., Guo, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hlc J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 06/05/24 S protein of SARS-CoV-2 in complex with 3711 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Y.Y., Guo, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hld H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 S protein of SARS-CoV-2 in complex with 26434 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Y.Y., Guo, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8hld I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 S protein of SARS-CoV-2 in complex with 26434 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Y.Y., Guo, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8hld J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 S protein of SARS-CoV-2 in complex with 26434 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Y.Y., Guo, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8ikg S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of human receptor with G proteins Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Shen, S.Y., Shao, Z.H. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ikh S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of human receptor with G proteins Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Shen, S.Y., Shao, Z.H. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jj0 E F 0 D | A protein | protein NA | NA glutamate receptor ionotropic, nmda 1 | glutamate receptor ionotropic, nmda 2a MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in one fab bind conformation Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Wang, H., Zhu, S. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jj1 H G 0 D protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in two fab conformation Homo sapiens homo sapiens homo sapiens homo sapiens Wang, H., Zhu, S. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8jj1 E F 0 B protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in two fab conformation Homo sapiens homo sapiens homo sapiens homo sapiens Wang, H., Zhu, S. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8jj2 E F 0 D protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 06/05/24 Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in one fab conformation Homo sapiens homo sapiens homo sapiens homo sapiens Wang, H., Zhu, S. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8jmm H h 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm I i 0 B protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm J j 0 B protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm K k 0 C protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm M m 0 D protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm N n 0 D protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm O o 0 E protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm P p 0 E protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm Q q 0 F protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm R r 0 F protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm G g 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jmm L l 0 C protein NA spike glycoprotein VIRAL PROTEIN 06/12/24 Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A., Mao, Q., Chen, Z., Huang, J., Sun, L. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jn1 H L 0 C | E protein | protein NA | NA envelope protein (fragment) | envelope protein (fragment) VIRUS 06/12/24 Cryo-EM structure of dengue virus serotype 3 strain EHIE46200Y19 in complex with human antibody DENV-115 IgG at 4 deg C (subparticle LLR-LRR) Dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 | dengue virus type 3 Fibriansah, G., Ng, T.S., Tan, A.W.K., Shi, J., Lok, S.M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8jn2 H L 0 E | C protein | protein NA | NA envelope protein | envelope protein VIRUS/IMMUNE SYSTEM 06/12/24 Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 4 deg C (subparticle LLR-LRR) Dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 | dengue virus type 3 Fibriansah, G., Ng, T.S., Tan, A.W.K., Shi, J., Lok, S.M. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8jn3 H L 0 C | E protein | protein NA | NA envelope protein | envelope protein VIRUS/IMMUNE SYSTEM 06/12/24 Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-115 Fab at 37 deg C (subparticle LLR-LRR) Dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 | dengue virus type 3 Fibriansah, G., Ng, T.S., Tan, A.W.K., Shi, J., Lok, S.M. 5.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8jn4 H L 0 C | E protein | protein NA | NA envelope protein | envelope protein VIRUS/IMMUNE SYSTEM 06/12/24 Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 4 deg C (subparticle LLR-LRR) Dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 | dengue virus type 3 Fibriansah, G., Ng, T.S., Tan, A.W.K., Shi, J., Lok, S.M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8jn5 H L 0 C | E protein | protein NA | NA envelope protein | envelope protein VIRUS/IMMUNE SYSTEM 06/12/24 Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 37 deg C (subparticle LLR-LRR) Dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 | dengue virus type 3 Fibriansah, G., Ng, T.S., Tan, A.W.K., Shi, J., Lok, S.M. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8jn6 H L 0 C protein NA polyprotein (fragment) VIRUS/IMMUNE SYSTEM 06/12/24 Cryo-EM structure of the small tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C Dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 Fibriansah, G., Ng, T.S., Tan, A.W.K., Shi, J., Lok, S.M. 9.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8jn7 H L 0 C protein NA polyprotein (fragment) VIRUS/IMMUNE SYSTEM 06/12/24 Cryo-EM structure of the big tail club shape particle of dengue virus serotype 3 strain CH53489 in complex with human antibody DENV-290 Fab at 37 deg C dengue virus type 3; Homo sapiens homo sapiens homo sapiens dengue virus type 3 Fibriansah, G., Ng, T.S., Tan, A.W.K., Shi, J., Lok, S.M. 11.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8jow A a 0 B peptide NA arg-pro-his-phe-pro-gln-phe-sep-tyr-ser-ala-ser IMMUNE SYSTEM 06/12/24 Crystal structure of rabbit antibody with phosphorylated peptide bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Kawade, R., Tsumoto, K. 1.4 X-RAY DIFFRACTION 0.199 0.162 True True unknown unknown unknown None None None None None 8jow C c 0 D peptide NA arg-pro-his-phe-pro-gln-phe-sep-tyr-ser-ala-ser IMMUNE SYSTEM 06/12/24 Crystal structure of rabbit antibody with phosphorylated peptide bound Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Kawade, R., Tsumoto, K. 1.4 X-RAY DIFFRACTION 0.199 0.162 True True unknown unknown unknown None None None None None 8jys A NA 0 B protein NA spike protein s1 VIRAL PROTEIN 06/12/24 SARS-CoV-2 Spike RBD (dimer) in complex with two 2S-1244 nanobodies Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Yang, Y., Zhang, C.H. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jys C NA 0 D protein NA spike protein s1 VIRAL PROTEIN 06/12/24 SARS-CoV-2 Spike RBD (dimer) in complex with two 2S-1244 nanobodies Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Yang, Y., Zhang, C.H. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8p2e A B 0 NA NA NA NA SUGAR BINDING PROTEIN 06/05/24 Homotypic interacting B1 fab bound to Chondroitin Sulfate A Homo sapiens homo sapiens homo sapiens Raghavan, S.S.R., Dagil, R., Wang, K.T., Salanti, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8p2e C D 0 NA NA NA NA SUGAR BINDING PROTEIN 06/05/24 Homotypic interacting B1 fab bound to Chondroitin Sulfate A Homo sapiens homo sapiens homo sapiens Raghavan, S.S.R., Dagil, R., Wang, K.T., Salanti, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8p2e E F 0 NA NA NA NA SUGAR BINDING PROTEIN 06/05/24 Homotypic interacting B1 fab bound to Chondroitin Sulfate A Homo sapiens homo sapiens homo sapiens Raghavan, S.S.R., Dagil, R., Wang, K.T., Salanti, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8p2e G H 0 NA NA NA NA SUGAR BINDING PROTEIN 06/05/24 Homotypic interacting B1 fab bound to Chondroitin Sulfate A Homo sapiens homo sapiens homo sapiens Raghavan, S.S.R., Dagil, R., Wang, K.T., Salanti, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8p5m G L 0 I protein NA spike protein s1 VIRAL PROTEIN 01/08/09 SARS-CoV-2 Spike RBD in complex with Mab-23 (Fab) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Das, H., Hallberg, B.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8pwu B b 0 A protein NA reticulocyte-binding protein homolog 5 CELL CYCLE 06/05/24 PfRH5 bound to monoclonal antibody MAD10-255 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.148 X-RAY DIFFRACTION 0.264 0.242 True True unknown unknown unknown None None None None None 8pwu D d 0 C protein NA reticulocyte-binding protein homolog 5 CELL CYCLE 06/05/24 PfRH5 bound to monoclonal antibody MAD10-255 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.148 X-RAY DIFFRACTION 0.264 0.242 True True unknown unknown unknown None None None None None 8pwu F f 0 E protein NA reticulocyte-binding protein homolog 5 CELL CYCLE 06/05/24 PfRH5 bound to monoclonal antibody MAD10-255 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.148 X-RAY DIFFRACTION 0.264 0.242 True True unknown unknown unknown None None None None None 8pwu H h 0 G protein NA reticulocyte-binding protein homolog 5 CELL CYCLE 06/05/24 PfRH5 bound to monoclonal antibody MAD10-255 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.148 X-RAY DIFFRACTION 0.264 0.242 True True unknown unknown unknown None None None None None 8pwu J j 0 I protein NA reticulocyte-binding protein homolog 5 CELL CYCLE 06/05/24 PfRH5 bound to monoclonal antibody MAD10-255 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.148 X-RAY DIFFRACTION 0.264 0.242 True True unknown unknown unknown None None None None None 8pwv B b 0 A protein NA reticulocyte-binding protein homolog 5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD8-502 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 2.07 X-RAY DIFFRACTION 0.279 0.269 True True unknown unknown unknown None None None None None 8pwv D d 0 C protein NA reticulocyte-binding protein homolog 5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD8-502 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 2.07 X-RAY DIFFRACTION 0.279 0.269 True True unknown unknown unknown None None None None None 8pwv F f 0 E protein NA reticulocyte-binding protein homolog 5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD8-502 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 2.07 X-RAY DIFFRACTION 0.279 0.269 True True unknown unknown unknown None None None None None 8pwv H h 0 G protein NA reticulocyte-binding protein homolog 5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD8-502 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 2.07 X-RAY DIFFRACTION 0.279 0.269 True True unknown unknown unknown None None None None None 8pww B b 0 A protein NA reticulocyte-binding protein homolog 5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD8-151 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 1.945 X-RAY DIFFRACTION 0.252 0.230 True True unknown unknown unknown None None None None None 8pww D d 0 C protein NA reticulocyte-binding protein homolog 5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD8-151 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 1.945 X-RAY DIFFRACTION 0.252 0.230 True True unknown unknown unknown None None None None None 8pwx A a 0 B protein NA reticulocyte-binding protein homolog 5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody R5.008 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.2 X-RAY DIFFRACTION 0.294 0.240 True True unknown unknown unknown None None None None None 8q5d B C 0 A protein NA pfrh5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD10-466 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.2 X-RAY DIFFRACTION 0.317 0.272 False True IGHV1 IGKV1 Kappa None None None None None 8q5d E F 0 D protein NA pfrh5 CELL ADHESION 06/05/24 PfRH5 bound to monoclonal antibody MAD10-466 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.2 X-RAY DIFFRACTION 0.317 0.272 False True IGHV1 IGKV1 Kappa None None None None None 8r9w H L 0 A protein NA spike protein VIRAL PROTEIN 06/05/24 PDCoV spike glycoprotein ectodomain in complex with the 22C10 antibody Fab fragment Deltacoronavirus; Homo sapiens homo sapiens homo sapiens deltacoronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8r9w D F 0 B protein NA spike protein VIRAL PROTEIN 06/05/24 PDCoV spike glycoprotein ectodomain in complex with the 22C10 antibody Fab fragment Deltacoronavirus; Homo sapiens homo sapiens homo sapiens deltacoronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8r9w E G 0 C protein NA spike protein VIRAL PROTEIN 06/05/24 PDCoV spike glycoprotein ectodomain in complex with the 22C10 antibody Fab fragment Deltacoronavirus; Homo sapiens homo sapiens homo sapiens deltacoronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8r9x H L 0 A protein NA pdcov spike glycoprotein s1a domain VIRAL PROTEIN 06/05/24 Local refinement of the PDCoV spike glycoprotein ectodomain in complex with the 22C10 antibody Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens Debski-Antoniak, O., Hurdiss, D.L. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8r9y B C 0 A protein NA spike protein VIRAL PROTEIN 06/05/24 S1B domain of the PDCoV spike glycoprotein in complex with the 67B12 and 42H3 antibody Fab fragments Homo sapiens; Porcine deltacoronavirus homo sapiens homo sapiens porcine deltacoronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8r9y H L 0 A protein NA spike protein VIRAL PROTEIN 06/05/24 S1B domain of the PDCoV spike glycoprotein in complex with the 67B12 and 42H3 antibody Fab fragments Homo sapiens; Porcine deltacoronavirus homo sapiens homo sapiens porcine deltacoronavirus Debski-Antoniak, O., Hurdiss, D.L. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8r9z B C 0 A protein NA spike protein VIRAL PROTEIN 06/05/24 S1B domain of the PDCoV spike glycoprotein in complex with the 67B12 and 46E6 antibody Fab fragments Homo sapiens; Porcine deltacoronavirus homo sapiens homo sapiens porcine deltacoronavirus Debski-Antoniak, O., Hurdiss, D.L. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8r9z H L 0 A protein NA spike protein VIRAL PROTEIN 06/05/24 S1B domain of the PDCoV spike glycoprotein in complex with the 67B12 and 46E6 antibody Fab fragments Homo sapiens; Porcine deltacoronavirus homo sapiens homo sapiens porcine deltacoronavirus Debski-Antoniak, O., Hurdiss, D.L. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tzn G H 0 C protein NA 10e8-gt10.2 mper scaffold IMMUNE SYSTEM 06/12/24 Crystal structure of 10E8-GT10.2 HIV-1 MPER scaffold in complex with a non-human primate W3-01 Fab unidentified monkey unidentified monkey unidentified monkey unidentified monkey Lee, C.C.D., Wilson, I.A. 3.11 X-RAY DIFFRACTION 0.284 0.246 False True IGHV4 IGLV3 Lambda None None None None None 8tzn B D 0 A protein NA 10e8-gt10.2 mper scaffold IMMUNE SYSTEM 06/12/24 Crystal structure of 10E8-GT10.2 HIV-1 MPER scaffold in complex with a non-human primate W3-01 Fab unidentified monkey unidentified monkey unidentified monkey unidentified monkey Lee, C.C.D., Wilson, I.A. 3.11 X-RAY DIFFRACTION 0.284 0.246 False True IGHV4 IGLV3 Lambda None None None None None 8tzw H L 0 C protein NA 10e8-gt4 epitope scaffold IMMUNE SYSTEM 06/12/24 Crystal structure of 10E8-GT4 scaffold in complex with a human 10E8 inferred germline (10E8-iGL1) Homo sapiens homo sapiens homo sapiens homo sapiens Irimia, A., Wilson, I.A. 2.66 X-RAY DIFFRACTION 0.259 0.216 False True IGHV3 IGLV3 Lambda None None None None None 8u03 H L 0 C protein NA 10e8-gt10.1 epitope scaffold IMMUNE SYSTEM 06/12/24 Crystal structure of non-glycosylated 10E8-GT10.1 scaffold in complex with a human 10E8 NGS precursor (10E8-NGS-03) Homo sapiens homo sapiens homo sapiens homo sapiens Irimia, A., Wilson, I.A. 2.72 X-RAY DIFFRACTION 0.249 0.220 False True IGHV3 IGLV3 Lambda None None None None None 8u08 H L 0 C protein NA 10e8-gt11 epitope scaffold IMMUNE SYSTEM 06/12/24 Crystal structure of 10E8-GT11 scaffold in complex with a human 10E8 inferred germline (10E8-iGL1) Homo sapiens homo sapiens homo sapiens homo sapiens Irimia, A., Wilson, I.A. 1.98 X-RAY DIFFRACTION 0.236 0.186 False True IGHV3 IGLV3 Lambda None None None None None 8uek A NA 19 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 18 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 17 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 16 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 15 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 14 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 13 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 12 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 11 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 10 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 9 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 8 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 7 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 6 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 5 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 4 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 3 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 2 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 1 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8uek A NA 0 NA NA NA NA IMMUNE SYSTEM 06/12/24 Solution structure of ACKR3-targeting nanobody VUN701 Lama glama lama glama Schlimgen, R.R., Peterson, F.C., Volkman, B.F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 8v2e A B 0 C protein NA 10e8 epitope scaffold b055 IMMUNE SYSTEM 06/12/24 Crystal structure of B055 scaffold boost immunogen in complex with a mature 10E8 Fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Cho, S.Y., Wilson, I.A. 2.62 X-RAY DIFFRACTION 0.276 0.228 False True IGHV3 IGLV3 Lambda None None None None None 8v2e D E 0 F protein NA 10e8 epitope scaffold b055 IMMUNE SYSTEM 06/12/24 Crystal structure of B055 scaffold boost immunogen in complex with a mature 10E8 Fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Cho, S.Y., Wilson, I.A. 2.62 X-RAY DIFFRACTION 0.276 0.228 False True IGHV3 IGLV3 Lambda None None None None None 8v4f B D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 Model and map from local refinement of a CAB-A17 - Omicron Ba.1 spike complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8wlj D NA 0 A protein NA synaptic vesicular amine transporter TRANSPORT PROTEIN/IMMUNE SYSTEM 06/12/24 Cryo-EM structure of human apo VMAT2 with nanobody in an outward-facing conformation Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Qu, Q., Wang, Y., Zhou, Z. 3.6 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8wsn B C 0 D protein NA gn VIRAL PROTEIN/IMMUNE SYSTEM 06/12/24 Crystal structure of SFTSV Gn and antibody SF1 Homo sapiens; SFTS virus JS4 homo sapiens homo sapiens sfts virus js4 Chang, Z., Gao, F., Wu, Y. 2.8 X-RAY DIFFRACTION 0.291 0.240 False True IGHV5 IGKV3 Kappa None None None None None 8wsn E F 0 A protein NA gn VIRAL PROTEIN/IMMUNE SYSTEM 06/12/24 Crystal structure of SFTSV Gn and antibody SF1 Homo sapiens; SFTS virus JS4 homo sapiens homo sapiens sfts virus js4 Chang, Z., Gao, F., Wu, Y. 2.8 X-RAY DIFFRACTION 0.291 0.240 False True IGHV5 IGKV3 Kappa None None None None None 8wsp B C 0 A protein NA gn VIRAL PROTEIN/IMMUNE SYSTEM 06/12/24 Crystal structure of SFTSV Gn and antibody SF5 Homo sapiens; SFTS virus SD4 homo sapiens homo sapiens sfts virus sd4 Chang, Z., Gao, F., Wu, Y. 2.51 X-RAY DIFFRACTION 0.243 0.195 False True IGHV3 IGLV3 Lambda None None None None None 8wsp E F 0 D protein NA gn VIRAL PROTEIN/IMMUNE SYSTEM 06/12/24 Crystal structure of SFTSV Gn and antibody SF5 Homo sapiens; SFTS virus SD4 homo sapiens homo sapiens sfts virus sd4 Chang, Z., Gao, F., Wu, Y. 2.51 X-RAY DIFFRACTION 0.243 0.195 False True IGHV3 IGLV3 Lambda None None None None None 8wsu B C 0 A protein NA glycoprotein c VIRAL PROTEIN/IMMUNE SYSTEM 06/12/24 Crystal structure of SFTSV Gc and antibody Homo sapiens; SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) homo sapiens homo sapiens sfts phlebovirus (isolatesftsv/human/china/hb29/2010) Chang, Z., Gao, F., Wu, Y. 3.3 X-RAY DIFFRACTION 0.267 0.207 False True IGHV3 IGKV1 Kappa None None None None None 8wsu E F 0 D protein NA glycoprotein c VIRAL PROTEIN/IMMUNE SYSTEM 06/12/24 Crystal structure of SFTSV Gc and antibody Homo sapiens; SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) homo sapiens homo sapiens sfts phlebovirus (isolatesftsv/human/china/hb29/2010) Chang, Z., Gao, F., Wu, Y. 3.3 X-RAY DIFFRACTION 0.267 0.207 False True IGHV3 IGKV1 Kappa None None None None None 8x0x G K 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 Crystal structure of JE-5C in complex with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 3.45 X-RAY DIFFRACTION 0.285 0.240 False True IGHV3 IGKV1 Kappa None None None None None 8x0x H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 Crystal structure of JE-5C in complex with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 3.45 X-RAY DIFFRACTION 0.285 0.240 False True IGHV3 IGKV1 Kappa None None None None None 8x0y E F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 Crystal structure of JM-1A in complex with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 1.94 X-RAY DIFFRACTION 0.223 0.194 False True IGHV4 IGKV1 Kappa None None None None None 8x0y G I 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 Crystal structure of JM-1A in complex with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 1.94 X-RAY DIFFRACTION 0.223 0.194 False True IGHV4 IGKV1 Kappa None None None None None 8x8l E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 06/12/24 Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Xu, H.E., You, C., Zhao, L., Li, J. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8x8n E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 06/12/24 Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Xu, H.E., You, C., Zhao, L., Li, J. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xs3 A B 0 C protein NA protein opg190 VIRAL PROTEIN/IMMUNE SYSTEM 06/12/24 Structure of MPXV B6 and D68 fab complex Homo sapiens; Monkeypox virus homo sapiens homo sapiens monkeypox virus wu, L.L., Sun, J.Q. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8yro H L 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 Delta Spike in complex with JL-8C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Nguyen, V.H.T., Chen, X. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 8yro B C 0 P protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 Delta Spike in complex with JL-8C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Nguyen, V.H.T., Chen, X. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 8yro E F 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 Delta Spike in complex with JL-8C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Nguyen, V.H.T., Chen, X. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 8yrp n o 0 B | A | C protein | protein | protein NA | NA | NA spike glycoprotein | spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 SARS-CoV-2 Delta Spike in complex with JM-1A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Nguyen, V.H.T., Chen, X. 3.64 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV1 Kappa None None None None None 8yut N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the amthamine-bound H2R-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Shen, Q., Tang, X., Wen, X., Cheng, S., Xiao, P., Zang, S., Shen, D., Jiang, L., Zheng, Y., Zhang, H., Xu, H., Mao, C., Zhang, M., Hu, W., Sun, J., Chen, Z., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8yuu S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/05/24 Cryo-EM structure of the histamine-bound H3R-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Shen, Q., Tang, X., Wen, X., Cheng, S., Xiao, P., Zang, S., Shen, D., Jiang, L., Zheng, Y., Zhang, H., Xu, H., Mao, C., Zhang, M., Hu, W., Sun, J., Chen, Z., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yuv S s 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the immepip-bound H3R-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Shen, Q., Tang, X., Wen, X., Cheng, S., Xiao, P., Zang, S., Shen, D., Jiang, L., Zheng, Y., Zhang, H., Xu, H., Mao, C., Zhang, M., Hu, W., Sun, J., Chen, Z., Zhang, Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8yz6 D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/24 SARS-CoV-2 Spike (BA.1) in complex with Fab of JH-8B Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 4.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 9fgr E e 0 C protein NA spike glycoprotein VIRAL PROTEIN 06/05/24 SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Berlinguer, M., Chaves-Sanjuan, A., Milazzo, F.M., Minenkova, O., De Santis, R., Bolognesi, M. 4.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9fgs E e 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 06/12/24 SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv41N (focused refinement) Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Berlinguer, M., Chaves-Sanjuan, A., Milazzo, F.M., Minenkova, O., De Santis, R., Bolognesi, M. 4.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9fgt E e 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 06/12/24 SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76 (focused refinement) Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Berlinguer, M., Chaves-Sanjuan, A., Milazzo, F.M., Minenkova, O., De Santis, R., Bolognesi, M. 3.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9fgu E e 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 06/12/24 SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement) Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Berlinguer, M., Chaves-Sanjuan, A., Milazzo, F.M., Minenkova, O., De Santis, R., Bolognesi, M. 4.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8t1g G I 0 D | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 05/29/24 The crystal structure of hemagglutinin form a h7n9 influenza virus (a/shanghai/1/2013) in complex with antibody 1E11 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Zhou, T., Kwong, P.D. 3.5 X-RAY DIFFRACTION 0.215 0.182 False True IGHV4 IGKV2 Kappa None None None None None 8t1g H L 0 F | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 05/29/24 The crystal structure of hemagglutinin form a h7n9 influenza virus (a/shanghai/1/2013) in complex with antibody 1E11 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Zhou, T., Kwong, P.D. 3.5 X-RAY DIFFRACTION 0.215 0.182 False True IGHV4 IGKV2 Kappa None None None None None 8t1g J K 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM/VIRAL PROTEIN 05/29/24 The crystal structure of hemagglutinin form a h7n9 influenza virus (a/shanghai/1/2013) in complex with antibody 1E11 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Zhou, T., Kwong, P.D. 3.5 X-RAY DIFFRACTION 0.215 0.182 False True IGHV4 IGKV2 Kappa None None None None None 8fsl A NA 0 E protein NA mesothelin ANTITUMOR PROTEIN 05/29/24 Human Mesothelin bound to a neutralizing VH domain antibody Escherichia coli; Insect expression vector pBlueBacmsGCA1His insect expression vector pbluebacmsgca1his Calero, G. 2.9 X-RAY DIFFRACTION 0.254 0.239 False True IGHV3 NA NA None None None None None 8fsl C NA 0 E protein NA mesothelin ANTITUMOR PROTEIN 05/29/24 Human Mesothelin bound to a neutralizing VH domain antibody Escherichia coli; Insect expression vector pBlueBacmsGCA1His insect expression vector pbluebacmsgca1his Calero, G. 2.9 X-RAY DIFFRACTION 0.254 0.239 False True IGHV3 NA NA None None None None None 8fsl D NA 0 F protein NA mesothelin ANTITUMOR PROTEIN 05/29/24 Human Mesothelin bound to a neutralizing VH domain antibody Escherichia coli; Insect expression vector pBlueBacmsGCA1His insect expression vector pbluebacmsgca1his Calero, G. 2.9 X-RAY DIFFRACTION 0.254 0.239 False True IGHV3 NA NA None None None None None 8fsl B NA 0 F protein NA mesothelin ANTITUMOR PROTEIN 05/29/24 Human Mesothelin bound to a neutralizing VH domain antibody Escherichia coli; Insect expression vector pBlueBacmsGCA1His insect expression vector pbluebacmsgca1his Calero, G. 2.9 X-RAY DIFFRACTION 0.254 0.239 False True IGHV3 NA NA None None None None None 8jh5 C NA 0 A protein NA auxin efflux carrier component 1 PLANT PROTEIN 05/29/24 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the Naproxen-bound state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jh5 D NA 0 B protein NA auxin efflux carrier component 1 PLANT PROTEIN 05/29/24 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the Naproxen-bound state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jin P p 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/29/24 The local refined map of XBB spike protein (S) in complex with bispecific antibody G7-Fc Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Ma, Y., Mao, Q., Wang, Y., Zhang, Z. 2.45 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jin B b 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/29/24 The local refined map of XBB spike protein (S) in complex with bispecific antibody G7-Fc Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Ma, Y., Mao, Q., Wang, Y., Zhang, Z. 2.45 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jio C B 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/29/24 XBB spike protein (S) in complex with monoclonal antibody 6I18 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ma, Y., Mao, Q., Wang, Y., Zhang, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8jsb A a 0 NA NA NA NA ANTIVIRAL PROTEIN 05/29/24 Antibody scFv against the Matrix protein 2 of influenza virus Homo sapiens homo sapiens Kumar, U., Gaur, V., Salunke, D.M. 3.03 X-RAY DIFFRACTION 0.267 0.223 True True unknown unknown unknown None None None None None 8jsb B b 0 NA NA NA NA ANTIVIRAL PROTEIN 05/29/24 Antibody scFv against the Matrix protein 2 of influenza virus Homo sapiens homo sapiens Kumar, U., Gaur, V., Salunke, D.M. 3.03 X-RAY DIFFRACTION 0.267 0.223 True True unknown unknown unknown None None None None None 8jsb C c 0 NA NA NA NA ANTIVIRAL PROTEIN 05/29/24 Antibody scFv against the Matrix protein 2 of influenza virus Homo sapiens homo sapiens Kumar, U., Gaur, V., Salunke, D.M. 3.03 X-RAY DIFFRACTION 0.267 0.223 True True unknown unknown unknown None None None None None 8jsb D d 0 NA NA NA NA ANTIVIRAL PROTEIN 05/29/24 Antibody scFv against the Matrix protein 2 of influenza virus Homo sapiens homo sapiens Kumar, U., Gaur, V., Salunke, D.M. 3.03 X-RAY DIFFRACTION 0.267 0.223 True True unknown unknown unknown None None None None None 8k9k H h 0 A | B | G protein | protein | protein NA | NA | NA g protein subunit alpha i3 | guanine nucleotide binding protein, beta polypeptide 1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 05/29/24 Full agonist-bound mu-type opioid receptor-G protein complex Escherichia coli; Homo sapiens; Macaca mulatta; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct macaca mulatta | homo sapiens | homo sapiens Hisano, T., Uchikubo-Kamo, T., Shirouzu, M., Imai, S., Kaneko, S., Shimada, I. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8k9l H h 0 A | B | G protein | protein | protein NA | NA | NA g protein subunit alpha i3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 05/29/24 Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex Escherichia coli; Homo sapiens; Macaca mulatta; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct macaca mulatta | homo sapiens | homo sapiens Hisano, T., Uchikubo-Kamo, T., Shirouzu, M., Imai, S., Kaneko, S., Shimada, I. 3.05 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8qz1 C NA 0 B protein NA isoform b of potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58) Homo sapiens; Lama glama lama glama homo sapiens Rodstrom, K.E.J., Pike, A.C.W., Baronina, A., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 3.588 X-RAY DIFFRACTION 0.298 0.256 False True IGHV1 NA NA None None None None None 8qz1 D NA 0 A protein NA isoform b of potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58) Homo sapiens; Lama glama lama glama homo sapiens Rodstrom, K.E.J., Pike, A.C.W., Baronina, A., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 3.588 X-RAY DIFFRACTION 0.298 0.256 False True IGHV1 NA NA None None None None None 8qz2 C NA 0 B | A protein | protein NA | NA potassium channel subfamily k member 10 | potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Baronina, A., Pike, A.C.W., Rodstrom, K.E.J., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 3.5 X-RAY DIFFRACTION 0.308 0.280 False True IGHV1 NA NA None None None None None 8qz3 C NA 0 B protein NA potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) Homo sapiens; Lama glama lama glama homo sapiens Baronina, A., Pike, A.C.W., Rodstrom, K.E.J., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 2.4 X-RAY DIFFRACTION 0.291 0.278 False True IGHV1 NA NA None None None None None 8qz3 D NA 0 B protein NA potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) Homo sapiens; Lama glama lama glama homo sapiens Baronina, A., Pike, A.C.W., Rodstrom, K.E.J., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 2.4 X-RAY DIFFRACTION 0.291 0.278 False True IGHV1 NA NA None None None None None 8qz3 E NA 0 A protein NA potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) Homo sapiens; Lama glama lama glama homo sapiens Baronina, A., Pike, A.C.W., Rodstrom, K.E.J., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 2.4 X-RAY DIFFRACTION 0.291 0.278 False True IGHV1 NA NA None None None None None 8qz4 C NA 0 A protein NA potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76) Homo sapiens; Lama glama lama glama homo sapiens Rodstrom, K.E.J., Pike, A.C.W., Baronina, A., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 3.2 X-RAY DIFFRACTION 0.298 0.270 False True IGHV1 NA NA None None None None None 8qz4 D NA 0 B protein NA potassium channel subfamily k member 10 MEMBRANE PROTEIN 05/29/24 Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76) Homo sapiens; Lama glama lama glama homo sapiens Rodstrom, K.E.J., Pike, A.C.W., Baronina, A., Ang, J., Bushell, S.R., Chalk, R., Mukhopadhyay, S.M.M., Pardon, E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Tucker, S.J., Steyaert, J., Carpenter, E.P., Structural Genomics Consortium (SGC) 3.2 X-RAY DIFFRACTION 0.298 0.270 False True IGHV1 NA NA None None None None None 8sw4 H L 0 B protein NA envelope glycoprotein gp41 VIRAL PROTEIN 01/08/09 BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Zhang, S., Ward, A.B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8sw4 E F 0 I protein NA envelope glycoprotein gp41 VIRAL PROTEIN 01/08/09 BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Zhang, S., Ward, A.B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8sw4 J M 0 B protein NA envelope glycoprotein gp41 VIRAL PROTEIN 01/08/09 BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Zhang, S., Ward, A.B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8sw4 K N 0 G protein NA envelope glycoprotein gp41 VIRAL PROTEIN 01/08/09 BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Zhang, S., Ward, A.B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8sw4 O P 0 A protein NA bg505 gt1.1 sosip gp120 VIRAL PROTEIN 01/08/09 BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Zhang, S., Ward, A.B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8sw4 Q R 0 D protein NA bg505 gt1.1 sosip gp120 VIRAL PROTEIN 01/08/09 BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Zhang, S., Ward, A.B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8sw4 S T 0 C protein NA bg505 gt1.1 sosip gp120 VIRAL PROTEIN 01/08/09 BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 Human immunodeficiency virus 1; Macaca macaca macaca human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Zhang, S., Ward, A.B. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8ttf C D 0 A protein NA quinolone resistance protein nora TRANSPORT PROTEIN/IMMUNE SYSTEM 05/29/24 NorA double mutant - E222QD307N at pH 7.5 Homo sapiens; Staphylococcus aureus homo sapiens homo sapiens staphylococcus aureus Li, J.P., Li, Y., Koide, A., Kuang, H.H., Torres, V.J., Koide, S., Wang, D.N., Traaseth, N.J. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tth C D 0 A protein NA quinolone resistance protein nora TRANSPORT PROTEIN/IMMUNE SYSTEM 05/29/24 NorA single mutant - D307N at pH 7.5 Homo sapiens; Staphylococcus aureus homo sapiens homo sapiens staphylococcus aureus Li, J.P., Li, Y., Koide, A., Kuang, H.H., Torres, V.J., Koide, S., Wang, D.N., Traaseth, N.J. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8uwl E e 0 B | C protein | protein NA | NA g protein subunit q (gi2-mini-gq chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/29/24 5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) Homo sapiens homo sapiens homo sapiens | homo sapiens Barros-Alvarez, X., Kim, K., Panova, O., Roth, B.L., Skiniotis, G. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8v6u E e 0 B | C protein | protein NA | NA g protein alpha-subunit q (gi2-mini-gq chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/29/24 5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Wang, L., Kapolka, N., Skiniotis, G., Roth, B.L. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ykv E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of succinate receptor SUCR1 bound to compound 31 Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | rattus norvegicus Li, C., Liu, H., Li, J., Zhu, H., Fu, W., Xu, H.E. 2.48 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ykw E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 05/29/24 Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | rattus norvegicus Li, C., Liu, H., Li, J., Zhu, H., Fu, W., Xu, H.E. 2.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ykx E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANTE PROTEIN/IMMUNE SYSTEM 05/29/24 Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | rattus norvegicus Li, C., Liu, H., Li, J., Zhu, H., Fu, W., Xu, H.E. 2.69 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zc2 H G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 7.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc2 Q M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 7.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc2 R N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 7.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc2 J I 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 7.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc2 O K 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 7.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc2 P L 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 7.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc6 H G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 6.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc6 Q M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 6.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc6 R N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 6.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc6 J I 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 6.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc6 O K 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 6.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc6 P L 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/29/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 6.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8vue G H 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 05/22/24 L5A7 Fab bound to Indonesia2005 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Olia, A.S., Gorman, J., Kwong, P.D. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV1 Kappa None None None None None 8vue I J 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 05/22/24 L5A7 Fab bound to Indonesia2005 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Olia, A.S., Gorman, J., Kwong, P.D. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV1 Kappa None None None None None 8vue K L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN 05/22/24 L5A7 Fab bound to Indonesia2005 Hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Olia, A.S., Gorman, J., Kwong, P.D. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV1 Kappa None None None None None 8sfs D NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama Ketaren, N.E., Rout, M.P., Bonnano, J.B., Almo, S.C. 2.37 X-RAY DIFFRACTION 0.218 0.190 False True IGHV1 NA NA None None None None None 8sfs C NA 0 B protein NA green fluorescent protein IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama aequorea victoria Ketaren, N.E., Rout, M.P., Bonnano, J.B., Almo, S.C. 2.37 X-RAY DIFFRACTION 0.218 0.190 False True IGHV1 NA NA None None None None None 8c2r F E 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/22/24 SARS-CoV2 Omicron BA.1 spike in complex with CAB-A17 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Das, H., Hallberg, B.M. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8c2r R L 0 B protein NA spike glycoprotein VIRAL PROTEIN 05/22/24 SARS-CoV2 Omicron BA.1 spike in complex with CAB-A17 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Das, H., Hallberg, B.M. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8g8a A B 0 C peptide NA env polyprotein IMMUNE SYSTEM 05/22/24 Crystal structure of DH1317.8 Fab in complex with HIV proximal MPER peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Astavans, A., Ofek, G. 2.44 X-RAY DIFFRACTION 0.256 0.222 False True IGHV7 IGKV1 Kappa None None None None None 8g8a H L 0 P peptide NA env polyprotein IMMUNE SYSTEM 05/22/24 Crystal structure of DH1317.8 Fab in complex with HIV proximal MPER peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Astavans, A., Ofek, G. 2.44 X-RAY DIFFRACTION 0.256 0.222 False True IGHV7 IGKV1 Kappa None None None None None 8g8c H L 0 C peptide NA env polyprotein IMMUNE SYSTEM 05/22/24 Crystal structure of DH1322.1 Fab in complex with HIV proximal MPER peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Niyongabo, A., Janus, B.M., Ofek, G. 2.08 X-RAY DIFFRACTION 0.229 0.199 False True IGHV7 IGKV3 Kappa None None None None None 8g8c A B 0 P peptide NA env polyprotein IMMUNE SYSTEM 05/22/24 Crystal structure of DH1322.1 Fab in complex with HIV proximal MPER peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Niyongabo, A., Janus, B.M., Ofek, G. 2.08 X-RAY DIFFRACTION 0.229 0.199 False True IGHV7 IGKV3 Kappa None None None None None 8g8d H L 0 P peptide NA gp41 mper peptide IMMUNE SYSTEM 05/22/24 Crystal structure of DH1346 Fab in complex with HIV proximal MPER peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Niyongabo, A., Janus, B.M., Ofek, G. 2.02 X-RAY DIFFRACTION 0.234 0.198 False True IGHV7 IGLV3 Lambda None None None None None 8g8d A B 0 C peptide NA gp41 mper peptide IMMUNE SYSTEM 05/22/24 Crystal structure of DH1346 Fab in complex with HIV proximal MPER peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Niyongabo, A., Janus, B.M., Ofek, G. 2.02 X-RAY DIFFRACTION 0.234 0.198 False True IGHV7 IGLV3 Lambda None None None None None 8jf7 J K 0 B protein NA glutamate receptor ionotropic, nmda 2a,enhanced greenfluorescent protein MEMBRANE PROTEIN 05/22/24 Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab Muromegalovirus G4; Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus, muromegalovirus g4 Kou, Z., Zhu, S. 7.73 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV12 Kappa None None None None None 8jf7 NA E 0 NA NA NA NA MEMBRANE PROTEIN 05/22/24 Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab Muromegalovirus G4; Mus musculus; Rattus norvegicus mus musculus Kou, Z., Zhu, S. 7.73 ELECTRON MICROSCOPY NA NA False True NA IGKV3 Kappa None None None None None 8jf7 F NA 0 A protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 05/22/24 Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab Muromegalovirus G4; Mus musculus; Rattus norvegicus mus musculus rattus norvegicus Kou, Z., Zhu, S. 7.73 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jf7 NA G 0 NA NA NA NA MEMBRANE PROTEIN 05/22/24 Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab Muromegalovirus G4; Mus musculus; Rattus norvegicus mus musculus Kou, Z., Zhu, S. 7.73 ELECTRON MICROSCOPY NA NA False True NA IGKV3 Kappa None None None None None 8jf7 H NA 0 C protein NA glutamate receptor ionotropic, nmda 1 MEMBRANE PROTEIN 05/22/24 Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab Muromegalovirus G4; Mus musculus; Rattus norvegicus mus musculus rattus norvegicus Kou, Z., Zhu, S. 7.73 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jpn S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/22/24 Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi Escherichia coli; Homo sapiens; Oplophorus gracilirostris homo sapiens homo sapiens | homo sapiens Wang, T.X., Tang, W.Q., Li, F.H., Wang, J.Y. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jva B A 0 F protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N235 and S2L20 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Liu, H.H., Han, P., Qi, J.X. 2.81 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jva D NA 0 F protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N235 and S2L20 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Liu, B., Liu, H.H., Han, P., Qi, J.X. 2.81 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8kei C E 0 B protein NA cytochrome b-245 heavy chain IMMUNE SYSTEM 05/22/24 Cryo-EM structure of NADPH oxidase 2 in complex with p22phox and EROS Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Liang, S.Y., Liu, A.J., Liu, Y.Z., Ye, R.D. 3.56 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8sfv B NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 High affinity nanobodies to GFP Aequorea victoria; Lama glama lama glama Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 1.83 X-RAY DIFFRACTION 0.206 0.183 False True IGHV1 NA NA None None None None None 8sfx D NA 0 B protein NA green fluorescent protein IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama aequorea victoria Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 1.95 X-RAY DIFFRACTION 0.228 0.210 False True IGHV1 NA NA None None None None None 8sfx C NA 0 A protein NA green fluorescent protein IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama aequorea victoria Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 1.95 X-RAY DIFFRACTION 0.228 0.210 False True IGHV1 NA NA None None None None None 8sfz C NA 0 D protein NA green fluorescent protein IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama aequorea victoria Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 1.9 X-RAY DIFFRACTION 0.231 0.207 False True IGHV1 NA NA None None None None None 8sfz A NA 0 F protein NA green fluorescent protein IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama aequorea victoria Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 1.9 X-RAY DIFFRACTION 0.231 0.207 False True IGHV1 NA NA None None None None None 8sfz B NA 0 F protein NA green fluorescent protein IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama aequorea victoria Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 1.9 X-RAY DIFFRACTION 0.231 0.207 False True IGHV1 NA NA None None None None None 8sg3 B NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 3.11 X-RAY DIFFRACTION 0.304 0.273 False True IGHV1 NA NA None None None None None 8slc C NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 2.97 X-RAY DIFFRACTION 0.241 0.220 False True IGHV1 NA NA None None None None None 8slc D NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama Ketaren, N.E., Rout, M.P., Bonanno, J.B., Almo, S.C. 2.97 X-RAY DIFFRACTION 0.241 0.220 False True IGHV1 NA NA None None None None None 8stl C NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha Lama glama lama glama Nwafor, J.N., Srinivasan, L., Chen, Z., Gabelli, S.B., Iheanacho, A., Alzogaray, V., Klinke, S. 1.85 X-RAY DIFFRACTION 0.255 0.189 False True IGHV1 NA NA None None None None None 8stl B NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha Lama glama lama glama Nwafor, J.N., Srinivasan, L., Chen, Z., Gabelli, S.B., Iheanacho, A., Alzogaray, V., Klinke, S. 1.85 X-RAY DIFFRACTION 0.255 0.189 False True IGHV1 NA NA None None None None None 8stl A NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha Lama glama lama glama Nwafor, J.N., Srinivasan, L., Chen, Z., Gabelli, S.B., Iheanacho, A., Alzogaray, V., Klinke, S. 1.85 X-RAY DIFFRACTION 0.255 0.189 False True IGHV1 NA NA None None None None None 8stl D NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/24 Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha Lama glama lama glama Nwafor, J.N., Srinivasan, L., Chen, Z., Gabelli, S.B., Iheanacho, A., Alzogaray, V., Klinke, S. 1.85 X-RAY DIFFRACTION 0.255 0.189 False True IGHV1 NA NA None None None None None 8sve H L 0 NA NA NA NA CYTOKINE 05/22/24 Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR Homo sapiens homo sapiens homo sapiens DiDonato, M., Spraggon, G. 2.4 X-RAY DIFFRACTION 0.232 0.188 False True IGHV2 IGKV1 Kappa None None None None None 8sve I M 0 NA NA NA NA CYTOKINE 05/22/24 Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR Homo sapiens homo sapiens homo sapiens DiDonato, M., Spraggon, G. 2.4 X-RAY DIFFRACTION 0.232 0.188 False True IGHV2 IGKV1 Kappa None None None None None 8swh H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Local refinement of SARS-CoV-2 (HP-GSAS-Mut7) spike NTD in complex with TXG-0078 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Bangaru, B., Ward, A. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8sx3 A B 0 C protein NA 10e8-gt10.2 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10 Homo sapiens; Mus musculus; synthetic construct mus musculus mus musculus synthetic construct Huang, J., Ozorowski, G., Ward, A.B. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV12 Kappa None None None None None 8sx3 H L 0 C protein NA 10e8-gt10.2 immunogen VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10 Homo sapiens; Mus musculus; synthetic construct homo sapiens homo sapiens synthetic construct Huang, J., Ozorowski, G., Ward, A.B. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8th4 C D 0 A protein NA type-1 angiotensin ii receptor soluble cytochrome b562complex SIGNALING PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of AT118-L Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor and Losartan Escherichia coli; Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens, escherichia coli Skiba, M.A., Kruse, A.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8th4 B NA 0 A protein NA type-1 angiotensin ii receptor soluble cytochrome b562complex SIGNALING PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of AT118-L Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor and Losartan Escherichia coli; Homo sapiens; synthetic construct synthetic construct homo sapiens, escherichia coli Skiba, M.A., Kruse, A.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8uo9 B NA 0 A protein NA synaptic vesicle glycoprotein 2a TRANSPORT PROTEIN 05/22/24 Structure of synaptic vesicle protein 2A in complex with a nanobody Homo sapiens; Lama glama lama glama homo sapiens Mittal, A., Martin, M.F., Levin, E., Adams, C., Yang, M., Ledecq, M., Horyani, P.S., Coleman, J.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8uoa B NA 0 A protein NA synaptic vesicle glycoprotein 2a TRANSPORT PROTEIN 05/22/24 Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody Homo sapiens; Lama glama lama glama homo sapiens Mittal, A., Martin, M.F., Levin, E., Adams, C., Yang, M., Ledecq, M., Horyani, P.S., Coleman, J.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5k D NA 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., Ramamohan, A.R., McLellan, J.S. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5k G NA 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., Ramamohan, A.R., McLellan, J.S. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5k E NA 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., Ramamohan, A.R., McLellan, J.S. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5k F NA 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., Ramamohan, A.R., McLellan, J.S. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5k H NA 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., Ramamohan, A.R., McLellan, J.S. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v5k I NA 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.V., Ramamohan, A.R., McLellan, J.S. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v62 D NA 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.J., Ramamohan, A.R., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v62 E NA 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.J., Ramamohan, A.R., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v62 F NA 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.J., Ramamohan, A.R., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v62 G NA 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.J., Ramamohan, A.R., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v62 H NA 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.J., Ramamohan, A.R., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8v62 I NA 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 05/22/24 Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06 Human respirovirus 3; Lama glama lama glama human respirovirus 3 Johnson, N.J., Ramamohan, A.R., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8vuz A B 0 NA NA NA NA ANTIVIRAL PROTEIN 05/22/24 L5A7 Fab bound to 28H6E11 anti-idiotype Fab Homo sapiens homo sapiens homo sapiens Olia, A.S., Morano, N.C., Kwong, P.D. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8vuz H L 0 NA NA NA NA ANTIVIRAL PROTEIN 05/22/24 L5A7 Fab bound to 28H6E11 anti-idiotype Fab Homo sapiens homo sapiens homo sapiens Olia, A.S., Morano, N.C., Kwong, P.D. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV1 Kappa None None None None None 8vvb A B 0 NA NA NA NA ANTIVIRAL PROTEIN 05/22/24 Influenza antibody L5A7 Fab Homo sapiens homo sapiens homo sapiens Harris, D.R., Olia, A.S., Kwong, P.D. 1.78 X-RAY DIFFRACTION 0.209 0.174 False True IGHV6 IGKV1 Kappa None None None None None 8vvb C D 0 NA NA NA NA ANTIVIRAL PROTEIN 05/22/24 Influenza antibody L5A7 Fab Homo sapiens homo sapiens homo sapiens Harris, D.R., Olia, A.S., Kwong, P.D. 1.78 X-RAY DIFFRACTION 0.209 0.174 False True IGHV6 IGKV1 Kappa None None None None None 8yrg E e 0 B | C protein | protein NA | NA gs-mini-gq chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/08/09 CryoEM structure of fospropofol-bound MRGPRX4-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Cao, C., Fay, J.F., Roth, B.L. 3.14 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8suo I M 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 BA.2/AZD1061/AZD3152 structure analysis Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Oganesyan, V., van Dyk, N., Dippel, A., Barnes, A., O'Connor, E. 3.3 X-RAY DIFFRACTION 0.332 0.279 False True IGHV3 IGKV4 Kappa None None None None None 8suo H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 BA.2/AZD1061/AZD3152 structure analysis Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Oganesyan, V., van Dyk, N., Dippel, A., Barnes, A., O'Connor, E. 3.3 X-RAY DIFFRACTION 0.332 0.279 False True IGHV3 IGLV2 Lambda None None None None None 8f9m C D 0 G | A protein | protein NA | NA bg505_md64_n332-gt5 gp41 | bg505_md64_n332-gt5 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized wild type mice, and NHP monoclonal Fab RM20A3 Macaca mulatta; Mus musculus; synthetic construct macaca mulatta macaca mulatta synthetic construct | synthetic construct Ozorowski, G., Ward, A.B. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8f9m J M 0 I | E protein | protein NA | NA bg505_md64_n332-gt5 gp41 | bg505_md64_n332-gt5 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized wild type mice, and NHP monoclonal Fab RM20A3 Macaca mulatta; Mus musculus; synthetic construct macaca mulatta macaca mulatta synthetic construct | synthetic construct Ozorowski, G., Ward, A.B. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8f9m K N 0 B | F protein | protein NA | NA bg505_md64_n332-gt5 gp41 | bg505_md64_n332-gt5 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized wild type mice, and NHP monoclonal Fab RM20A3 Macaca mulatta; Mus musculus; synthetic construct macaca mulatta macaca mulatta synthetic construct | synthetic construct Ozorowski, G., Ward, A.B. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8vfv G I 0 K | E protein | protein NA | NA transmembrane protein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8vfv C D 0 F protein NA transmembrane protein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8vfv H L 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8vfv M N 0 B | J protein | protein NA | NA transmembrane protein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8f92 C D 0 I protein NA bg505_md39_b11 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab Human immunodeficiency virus; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus Torres, J.L., Ozorowski, G., Ward, A.B. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8f92 H L 0 A protein NA bg505_md39_b11 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab Human immunodeficiency virus; Macaca mulatta; Mus musculus mus musculus mus musculus human immunodeficiency virus Torres, J.L., Ozorowski, G., Ward, A.B. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV12 Kappa None None None None None 8f92 J M 0 B protein NA bg505_md39_b11 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab Human immunodeficiency virus; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus Torres, J.L., Ozorowski, G., Ward, A.B. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8f92 O Q 0 E protein NA bg505_md39_b11 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab Human immunodeficiency virus; Macaca mulatta; Mus musculus mus musculus mus musculus human immunodeficiency virus Torres, J.L., Ozorowski, G., Ward, A.B. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV12 Kappa None None None None None 8f92 K N 0 G protein NA bg505_md39_b11 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab Human immunodeficiency virus; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus Torres, J.L., Ozorowski, G., Ward, A.B. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8f92 P R 0 F protein NA bg505_md39_b11 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab Human immunodeficiency virus; Macaca mulatta; Mus musculus mus musculus mus musculus human immunodeficiency virus Torres, J.L., Ozorowski, G., Ward, A.B. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV12 Kappa None None None None None 8oyu E NA 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 01/08/09 Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '2 up 1 down' RBD conformation Enterobacteria phage T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Weckener, M., Naismith, J.H., Owens, R.J. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8oyu D NA 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 01/08/09 Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '2 up 1 down' RBD conformation Enterobacteria phage T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Weckener, M., Naismith, J.H., Owens, R.J. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8rda H L 0 H Hapten H1A 2-ethyl-N-(2-hydroxyphenyl)butanamide IMMUNE SYSTEM 01/08/09 Crystal structure of Haemophilus influenzae type b (Hib) DP2 oligosaccharide bound to Fab CA4 Homo sapiens homo sapiens homo sapiens homo sapiens Nonne, F., Dello Iacono, L. 2.29 X-RAY DIFFRACTION 0.270 0.226 False True IGHV3 IGKV3 Kappa None None None None None 8rdf H L 0 H Hapten H09 2,2-bis(fluoranyl)-3-[(1~{R},3~{R})-1-[6-fluoranyl-3-[2-(3-fluoranylpropylamino)ethoxy]-2-methyl-phenyl]-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]propan-1-ol IMMUNE SYSTEM 01/08/09 Crystal structure of Haemophilus influenzae type b (Hib) DP3 oligosaccharide bound to Fab CA4 Homo sapiens homo sapiens homo sapiens homo sapiens Nonne, F., Dello Iacono, L. 2.74 X-RAY DIFFRACTION 0.277 0.226 False True IGHV3 IGKV3 Kappa None None None None None 8tnl H L 0 I protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK1 Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Morano, N.C., Wu, X., Shapiro, L. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8tnl D E 0 K protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK1 Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Morano, N.C., Wu, X., Shapiro, L. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8tnl A B 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK1 Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Morano, N.C., Wu, X., Shapiro, L. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8toa H L 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK2 Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Morano, N.C., Becker, J.E., Wu, X., Shapiro, L. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8toa D E 0 K protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK2 Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Morano, N.C., Becker, J.E., Wu, X., Shapiro, L. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8toa A B 0 I protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK2 Homo sapiens; Influenza A virus (A/Shanghai/02/2013(H7N9)) homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Morano, N.C., Becker, J.E., Wu, X., Shapiro, L. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8xbe S s 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/15/24 Human GPR34 -Gi complex bound to S3E-LysoPS Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Kawahara, R., Shihoya, W., Nureki, O. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8zby H D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.1 spike trimer (x2-4P) in complex with 3 D1F6 Fabs (0 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zby G E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.1 spike trimer (x2-4P) in complex with 3 D1F6 Fabs (0 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zby I F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.1 spike trimer (x2-4P) in complex with 3 D1F6 Fabs (0 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zbz E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.71 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zbz Q M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.71 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zbz R N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.71 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc0 H G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc0 Q M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc0 R N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc1 E C 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, focused refinement of RBD region Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc3 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc3 Q M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc3 R N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 4.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc4 H G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc4 Q M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc4 R N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc5 E C 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, focused refinement of RBD region Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8zc5 F D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/15/24 SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, focused refinement of RBD region Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, Q., He, J., Xiong, X. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8ja5 H L 0 A protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Crystal structure of Nipah Virus attachment (G) glycoprotein in complex with neutralizing antibody 14F8 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Li, Y.H., Huang, X.Y., Xu, J.J., Chen, W. 2.79 X-RAY DIFFRACTION 0.245 0.217 False True IGHV2 IGKV1 Kappa None None None None None 8ja5 B C 0 D protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Crystal structure of Nipah Virus attachment (G) glycoprotein in complex with neutralizing antibody 14F8 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Li, Y.H., Huang, X.Y., Xu, J.J., Chen, W. 2.79 X-RAY DIFFRACTION 0.245 0.217 False True IGHV2 IGKV1 Kappa None None None None None 8owt A NA 0 B protein NA unknown VIRAL PROTEIN 01/08/09 SARS-CoV-2 spike RBD with A8 and H3 nanobodies bound Lama glama; Severe acute respiratory syndrome coronavirus 2 Mikolajek, H., Naismith, J.H., Owens, R.J. 2.37 X-RAY DIFFRACTION 0.249 0.213 False False IGHV1 NA NA None None None None None 8owt C NA 0 B protein NA unknown VIRAL PROTEIN 01/08/09 SARS-CoV-2 spike RBD with A8 and H3 nanobodies bound Lama glama; Severe acute respiratory syndrome coronavirus 2 Mikolajek, H., Naismith, J.H., Owens, R.J. 2.37 X-RAY DIFFRACTION 0.249 0.213 False False IGHV1 NA NA None None None None None 8owt D NA 0 E protein NA unknown VIRAL PROTEIN 01/08/09 SARS-CoV-2 spike RBD with A8 and H3 nanobodies bound Lama glama; Severe acute respiratory syndrome coronavirus 2 Mikolajek, H., Naismith, J.H., Owens, R.J. 2.37 X-RAY DIFFRACTION 0.249 0.213 False False IGHV1 NA NA None None None None None 8owt F NA 0 E protein NA unknown VIRAL PROTEIN 01/08/09 SARS-CoV-2 spike RBD with A8 and H3 nanobodies bound Lama glama; Severe acute respiratory syndrome coronavirus 2 Mikolajek, H., Naismith, J.H., Owens, R.J. 2.37 X-RAY DIFFRACTION 0.249 0.213 False False IGHV1 NA NA None None None None None 8owv B NA 0 E protein NA unknown VIRAL PROTEIN 01/08/09 H6 and F2 nanobodies bound to SARS-CoV-2 spike RBD Lama glama; Severe acute respiratory syndrome coronavirus 2 Mikolajek, H., Naismith, J.H., Owens, R.J. 1.73 X-RAY DIFFRACTION 0.223 0.197 False False IGHV1 NA NA None None None None None 8owv F NA 0 E protein NA unknown VIRAL PROTEIN 01/08/09 H6 and F2 nanobodies bound to SARS-CoV-2 spike RBD Lama glama; Severe acute respiratory syndrome coronavirus 2 Mikolajek, H., Naismith, J.H., Owens, R.J. 1.73 X-RAY DIFFRACTION 0.223 0.197 False False IGHV1 NA NA None None None None None 8oww B NA 0 A protein NA spike protein s2' VIRAL PROTEIN 05/08/24 B5-5 nanobody bound to SARS-CoV-2 spike RBD (Wuhan) Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Cornish, K.A.S., Naismith, J.H., Owens, R.J. 1.969 X-RAY DIFFRACTION 0.223 0.181 False True IGHV1 NA NA None None None None None 8pih B NA 0 A protein NA phospholipase a2 ALLERGEN 05/08/24 Structure of Api m1 in complex with two nanobodies Apis mellifera; Lama glama lama glama apis mellifera Aagaard, J.B., Gandini, R., Spillner, E., Miehe, M., Andersen, G.R. 1.76 X-RAY DIFFRACTION 0.202 0.171 False True IGHV1 NA NA None None None None None 8pih C NA 0 A protein NA phospholipase a2 ALLERGEN 05/08/24 Structure of Api m1 in complex with two nanobodies Apis mellifera; Lama glama lama glama apis mellifera Aagaard, J.B., Gandini, R., Spillner, E., Miehe, M., Andersen, G.R. 1.76 X-RAY DIFFRACTION 0.202 0.171 False True IGHV1 NA NA None None None None None 8pkc C NA 0 A protein NA phospholipase a2 ALLERGEN 05/08/24 Structure of Api m1 in complex with the AM1-4 nanobody Apis mellifera; Lama glama lama glama apis mellifera Aagaard, J.B., Gandini, R., Spillner, E., Miehe, M. 4.1 X-RAY DIFFRACTION 0.296 0.258 False True IGHV1 NA NA None None None None None 8pkc D NA 0 B protein NA phospholipase a2 ALLERGEN 05/08/24 Structure of Api m1 in complex with the AM1-4 nanobody Apis mellifera; Lama glama lama glama apis mellifera Aagaard, J.B., Gandini, R., Spillner, E., Miehe, M. 4.1 X-RAY DIFFRACTION 0.296 0.258 False True IGHV1 NA NA None None None None None 8qrf A B 0 E protein NA spike protein s1 VIRAL PROTEIN 05/08/24 SARS-CoV-2 delta RBD complexed with XBB-6 and beta-49 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.7 X-RAY DIFFRACTION 0.317 0.272 False True IGHV1 IGKV3 Kappa None None None None None 8qrf H L 0 E protein NA spike protein s1 VIRAL PROTEIN 05/08/24 SARS-CoV-2 delta RBD complexed with XBB-6 and beta-49 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.7 X-RAY DIFFRACTION 0.317 0.272 False True IGHV3 IGLV2 Lambda None None None None None 8qrg H L 0 E protein NA spike protein s1 VIRAL PROTEIN 05/08/24 SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1 Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.3 X-RAY DIFFRACTION 0.228 0.182 False True IGHV3 IGKV1 Kappa None None None None None 8qrg A NA 0 E protein NA spike protein s1 VIRAL PROTEIN 05/08/24 SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1 Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.3 X-RAY DIFFRACTION 0.228 0.182 False True IGHV1 NA NA None None None None None 8qtd H L 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 05/08/24 Local refinement of SARS-CoV-2 BA.2.86 Spike and XBB-7 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ren, J., Duyvesteyn, H.M.E., Stuart, D.I. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8r80 H L 0 R protein NA spike protein s1 VIRAL PROTEIN 05/08/24 SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 4.03 X-RAY DIFFRACTION 0.313 0.268 False True IGHV3 IGKV1 Kappa None None None None None 8r80 A B 0 E protein NA spike protein s1 VIRAL PROTEIN 05/08/24 SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 4.03 X-RAY DIFFRACTION 0.313 0.268 False True IGHV3 IGKV1 Kappa None None None None None 8r80 N NA 0 NA NA NA NA VIRAL PROTEIN 05/08/24 SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct Zhou, D., Ren, J., Stuart, D.I. 4.03 X-RAY DIFFRACTION 0.313 0.268 False True IGHV1 NA NA None None None None None 8r80 J NA 0 NA NA NA NA VIRAL PROTEIN 05/08/24 SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct Zhou, D., Ren, J., Stuart, D.I. 4.03 X-RAY DIFFRACTION 0.313 0.268 False True IGHV1 NA NA None None None None None 8r8k H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/08/24 XBB-4 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8t49 H L 0 A protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 8t49 C D 0 G protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t49 O Q 0 E protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 8t49 J M 0 I protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t49 P R 0 F protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 8t49 K N 0 B protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4a C D 0 I protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 05/08/24 MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4a H L 0 A protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 05/08/24 MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8t4a J M 0 B protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 05/08/24 MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4a O Q 0 E protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 05/08/24 MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8t4a K N 0 G protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 05/08/24 MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4a P R 0 F protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 05/08/24 MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8t4b C D 0 I protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4b H L 0 A protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8t4b J M 0 B protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4b O Q 0 E protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8t4b K N 0 G protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4b P R 0 F protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8t4d C D 0 G protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4d H L 0 A protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8t4d J M 0 I protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4d O Q 0 E protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8t4d K N 0 B protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4d P R 0 F protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8t4l C D 0 I protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4l H L 0 A protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8t4l J M 0 B protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4l O Q 0 E protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8t4l K N 0 G protein NA md65 n332-gt5 sosip gp41 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8t4l P R 0 F protein NA md65 n332-gt5 sosip gp120 VIRAL PROTEIN/Immune System 01/08/09 MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8tng H NA 0 E protein NA hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D., Xu, J. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tng I NA 0 C protein NA hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D., Xu, J. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tng J NA 0 A protein NA hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D., Xu, J. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tnh H NA 0 C protein NA hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D., Xu, J. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tnh I NA 0 E protein NA hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D., Xu, J. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tnh J NA 0 A protein NA hiv-1 bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D., Xu, J. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tvh G E 0 B protein NA fusion glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Langya henipavirus postfusion F protein in complex with 4G5 Fab, local refinement of the viral membrane proximal region Langya virus; Mus musculus mus musculus mus musculus langya virus Wang, Z., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV12 Kappa None None None None None 8tvh F D 0 A protein NA fusion glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Langya henipavirus postfusion F protein in complex with 4G5 Fab, local refinement of the viral membrane proximal region Langya virus; Mus musculus mus musculus mus musculus langya virus Wang, Z., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV12 Kappa None None None None None 8tvh I H 0 C protein NA fusion glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 Langya henipavirus postfusion F protein in complex with 4G5 Fab, local refinement of the viral membrane proximal region Langya virus; Mus musculus mus musculus mus musculus langya virus Wang, Z., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV12 Kappa None None None None None 8ut3 F I 0 C | B protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 CryoEM structure of A/Perth/16/2009 H3 in complex with flu HA central stem VH1-18 antibody UCA6 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Huang, J., Han, J., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ut4 I H 0 F | A | E protein | protein | protein NA | NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 CryoEM structure of A/Michigan/45/2015 H1 in complex with flu HA central stem VH1-18 antibody 09-1B12 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus | influenza a virus Huang, J., Han, J., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ut5 G H 0 F | A | E protein | protein | protein NA | NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 CryoEM structure of A/Michigan/45/2015 H1 in complex with flu HA central stem VH1-18 antibody UCA6_N55T Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus | influenza a virus Huang, J., Han, J., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8uwa U D 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 VH1-18 QxxV class antibody 09-1B12 bound to A/Perth/16/2009 H3N2 hemagglutinin Homo sapiens; Influenza A virus (A/Perth/16/2009(H3N2)) homo sapiens homo sapiens influenza a virus (a/perth/16/2009(h3n2)) Maurer, D.P. 4.02 X-RAY DIFFRACTION 0.254 0.230 False True IGHV1 IGKV3 Kappa None None None None None 8uwa F E 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 VH1-18 QxxV class antibody 09-1B12 bound to A/Perth/16/2009 H3N2 hemagglutinin Homo sapiens; Influenza A virus (A/Perth/16/2009(H3N2)) homo sapiens homo sapiens influenza a virus (a/perth/16/2009(h3n2)) Maurer, D.P. 4.02 X-RAY DIFFRACTION 0.254 0.230 False True IGHV1 IGKV3 Kappa None None None None None 8uwa H G 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 VH1-18 QxxV class antibody 09-1B12 bound to A/Perth/16/2009 H3N2 hemagglutinin Homo sapiens; Influenza A virus (A/Perth/16/2009(H3N2)) homo sapiens homo sapiens influenza a virus (a/perth/16/2009(h3n2)) Maurer, D.P. 4.02 X-RAY DIFFRACTION 0.254 0.230 False True IGHV1 IGKV3 Kappa None None None None None 8wnp B A 0 E protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab AA12 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus homo sapiens homo sapiens zika virus Chew, B.L.A., Luo, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wnp D C 0 F protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab AA12 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus homo sapiens homo sapiens zika virus Chew, B.L.A., Luo, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wnp G NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab AA12 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus lama glama Chew, B.L.A., Luo, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8wnp H NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab AA12 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus lama glama Chew, B.L.A., Luo, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8wnu B A 0 E protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab GB5 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus homo sapiens homo sapiens zika virus Chew, B.L.A., Luo, D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wnu D C 0 F protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab GB5 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus homo sapiens homo sapiens zika virus Chew, B.L.A., Luo, D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wnu G NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab GB5 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus lama glama Chew, B.L.A., Luo, D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8wnu H NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab GB5 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus lama glama Chew, B.L.A., Luo, D. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8wo4 B A 0 F protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab EB9 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus homo sapiens homo sapiens zika virus Chew, B.L.A., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wo4 D C 0 E protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab EB9 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus homo sapiens homo sapiens zika virus Chew, B.L.A., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wo4 G NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab EB9 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus lama glama Chew, B.L.A., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8wo4 H NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/08/24 ZIKV rsNS1 in complex with Fab EB9 and anti-fab nanobody Homo sapiens; Lama glama; Zika virus lama glama Chew, B.L.A., Luo, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8yx1 H L 0 R protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 05/08/24 CD40 in complex with Bleselumab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 2.7 X-RAY DIFFRACTION 0.265 0.204 False True IGHV4 IGKV1 Kappa None None None None None 8yx1 A B 0 C protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 05/08/24 CD40 in complex with Bleselumab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 2.7 X-RAY DIFFRACTION 0.265 0.204 False True IGHV4 IGKV1 Kappa None None None None None 8yx9 H L 0 A protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 05/08/24 CD40 in complex with Dacetuzumab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8yx9 B C 0 J protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 05/08/24 CD40 in complex with Dacetuzumab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8yx9 E F 0 D protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 05/08/24 CD40 in complex with Dacetuzumab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8yx9 G I 0 K protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 05/08/24 CD40 in complex with Dacetuzumab Fab Homo sapiens homo sapiens homo sapiens homo sapiens Caaveiro, J.M.M., Fernandez-Perez, J., Tsumoto, K. 2.8 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8k0c E F 0 A protein NA glycoprotein g VIRAL PROTEIN 05/01/24 Cryo-EM structure of conformation 1 of complex of Nipah virus attachment glycoprotein G with 1E5 neutralizing antibody Macaca mulatta; Nipah virus macaca mulatta macaca mulatta nipah virus Sun, M.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8k0c G H 0 B protein NA glycoprotein g VIRAL PROTEIN 05/01/24 Cryo-EM structure of conformation 1 of complex of Nipah virus attachment glycoprotein G with 1E5 neutralizing antibody Macaca mulatta; Nipah virus macaca mulatta macaca mulatta nipah virus Sun, M.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8k0d E F 0 A protein NA glycoprotein g VIRAL PROTEIN 05/01/24 Cryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibody Macaca mulatta; Nipah virus macaca mulatta macaca mulatta nipah virus Sun, M. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8k0d C D 0 B protein NA glycoprotein g VIRAL PROTEIN 05/01/24 Cryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibody Macaca mulatta; Nipah virus macaca mulatta macaca mulatta nipah virus Sun, M. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8k3c C D 0 B protein NA glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 05/01/24 Nipah virus Attachment glycoprotein with 41-6 antibody fragment Henipavirus nipahense; Homo sapiens homo sapiens homo sapiens henipavirus nipahense Sun, M.M. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8oud D NA 0 A protein NA neutral amino acid transporter b(0) MEMBRANE PROTEIN 05/01/24 Structure of the human neutral amino acid transporter ASCT2 in complex with nanobody 469 Homo sapiens; Lama glama lama glama homo sapiens Canul-Tec, J., Reyes, N. 2.31 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8oud E NA 0 B protein NA neutral amino acid transporter b(0) MEMBRANE PROTEIN 05/01/24 Structure of the human neutral amino acid transporter ASCT2 in complex with nanobody 469 Homo sapiens; Lama glama lama glama homo sapiens Canul-Tec, J., Reyes, N. 2.31 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8oud F NA 0 C protein NA neutral amino acid transporter b(0) MEMBRANE PROTEIN 05/01/24 Structure of the human neutral amino acid transporter ASCT2 in complex with nanobody 469 Homo sapiens; Lama glama lama glama homo sapiens Canul-Tec, J., Reyes, N. 2.31 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8r4b B NA 0 A protein NA rab family protein HYDROLASE 05/01/24 Roco protein from C. tepidum in the GTP state bound to the activating Nanobodies NbRoco1 and NbRoco2 Chlorobaculum tepidum; Lama glama lama glama chlorobaculum tepidum Galicia, C., Versees, W. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8r4b C NA 0 A protein NA rab family protein HYDROLASE 05/01/24 Roco protein from C. tepidum in the GTP state bound to the activating Nanobodies NbRoco1 and NbRoco2 Chlorobaculum tepidum; Lama glama lama glama chlorobaculum tepidum Galicia, C., Versees, W. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8r4c C NA 0 A protein NA rab family protein HYDROLASE 05/01/24 LRR domain of Roco protein from C. tepidum bound to the activating Nanobody NbRoco2 Chlorobaculum tepidum; Lama glama lama glama chlorobaculum tepidum Galicia, C., Versees, W. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8r4d B NA 0 A protein NA rab family protein HYDROLASE 05/01/24 Focused map on the Roc-COR domains of the Roco protein from C. tepidum in the GTP state bound to the activating Nanobody NbRoco1 Chlorobaculum tepidum; Lama glama lama glama chlorobaculum tepidum Galicia, C., Versees, W. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8sm1 H L 0 G protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 05/01/24 CRYSTAL STRUCTURE OF HUMAN ANTIBODY 769A9 IN COMPLEX WITH EPSTEIN-BARR VIRUS MAJOR GLYCOPROTEIN GP350 Homo sapiens; Human herpesvirus 4 homo sapiens homo sapiens human herpesvirus 4 Chen, W.-H., Bu, W., Cohen, J.I., Kanekiyo, M., Joyce, M.G. 3.29 X-RAY DIFFRACTION 0.298 0.258 False True IGHV1 IGKV3 Kappa None None None None None 8smm H L 0 A protein NA hyaluronan synthase 1 Transferase/Immune System 05/01/24 Xenopus laevis hyaluronan synthase 1 Homo sapiens; Xenopus laevis homo sapiens homo sapiens xenopus laevis Gorniak, I., Zimmer, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8smn H L 0 A protein NA hyaluronan synthase 1 Transferase/Immune System 05/01/24 Xenopus laevis hyaluronan synthase 1, nascent HA polymer bound state Homo sapiens; Xenopus laevis homo sapiens homo sapiens xenopus laevis Gorniak, I., Zimmer, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8smp H L 0 A protein NA hyaluronan synthase 1 Transferase/Immune System 05/01/24 Xenopus laevis hyaluronan synthase 1, UDP-bound, gating loop inserted state Homo sapiens; Xenopus laevis homo sapiens homo sapiens xenopus laevis Gorniak, I., Zimmer, J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8snc B NA 0 A protein NA hyaluronan synthase TRANSFERASE 05/01/24 Chlorella virus Hyaluronan Synthase bound to GlcA extended GlcNAc primer Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8snc C NA 0 A protein NA hyaluronan synthase TRANSFERASE 05/01/24 Chlorella virus Hyaluronan Synthase bound to GlcA extended GlcNAc primer Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8snd B NA 0 A protein NA hyaluronan synthase TRANSFERASE 05/01/24 Chlorella virus Hyaluronan Synthase bound to GlcNAc primer and UDP-GlcA Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8snd C NA 0 A protein NA hyaluronan synthase TRANSFERASE 05/01/24 Chlorella virus Hyaluronan Synthase bound to GlcNAc primer and UDP-GlcA Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8sne B NA 0 A protein NA hyaluronan synthase TRANSFERASE 05/01/24 Chlorella virus Hyaluronan Synthase bound to GlcA extended GlcNAc primer and UDP Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8sne C NA 0 A protein NA hyaluronan synthase TRANSFERASE 05/01/24 Chlorella virus Hyaluronan Synthase bound to GlcA extended GlcNAc primer and UDP Lama glama; Paramecium bursaria Chlorella virus CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Stephens, Z., Zimmer, J. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8t9b C G 0 L protein NA ephrin type-a receptor 2 IMMUNE SYSTEM 05/01/24 Structure of the CK variant of Fab F1 (FabC-F1) in complex with the C-terminal FN3 domain of EphA2 Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 4.2 X-RAY DIFFRACTION 0.315 0.296 False True IGHV3 IGKV1 Kappa None None None None None 8t9b A B 0 K protein NA ephrin type-a receptor 2 IMMUNE SYSTEM 05/01/24 Structure of the CK variant of Fab F1 (FabC-F1) in complex with the C-terminal FN3 domain of EphA2 Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 4.2 X-RAY DIFFRACTION 0.315 0.296 False True IGHV3 IGKV1 Kappa None None None None None 8t9b D E 0 I protein NA ephrin type-a receptor 2 IMMUNE SYSTEM 05/01/24 Structure of the CK variant of Fab F1 (FabC-F1) in complex with the C-terminal FN3 domain of EphA2 Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 4.2 X-RAY DIFFRACTION 0.315 0.296 False True IGHV3 IGKV1 Kappa None None None None None 8t9b F H 0 J protein NA ephrin type-a receptor 2 IMMUNE SYSTEM 05/01/24 Structure of the CK variant of Fab F1 (FabC-F1) in complex with the C-terminal FN3 domain of EphA2 Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 4.2 X-RAY DIFFRACTION 0.315 0.296 False True IGHV3 IGKV1 Kappa None None None None None 8tzu C NA 0 B protein NA spike protein s1 VIRAL PROTEIN 05/01/24 OC43 S1b domain in complex with WNb 293 and WNb 317 Human coronavirus OC43; Vicugna pacos vicugna pacos human coronavirus oc43 Pymm, P., Feng, J., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.266 0.227 False True IGHV1 NA NA None None None None None 8tzu D NA 0 B protein NA spike protein s1 VIRAL PROTEIN 05/01/24 OC43 S1b domain in complex with WNb 293 and WNb 317 Human coronavirus OC43; Vicugna pacos vicugna pacos human coronavirus oc43 Pymm, P., Feng, J., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.266 0.227 False True IGHV1 NA NA None None None None None 8tzu E NA 0 A protein NA spike protein s1 VIRAL PROTEIN 05/01/24 OC43 S1b domain in complex with WNb 293 and WNb 317 Human coronavirus OC43; Vicugna pacos vicugna pacos human coronavirus oc43 Pymm, P., Feng, J., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.266 0.227 False True IGHV1 NA NA None None None None None 8tzu G NA 0 A protein NA spike protein s1 VIRAL PROTEIN 05/01/24 OC43 S1b domain in complex with WNb 293 and WNb 317 Human coronavirus OC43; Vicugna pacos vicugna pacos human coronavirus oc43 Pymm, P., Feng, J., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.266 0.227 False True IGHV1 NA NA None None None None None 8tzu H NA 0 F protein NA spike protein s1 VIRAL PROTEIN 05/01/24 OC43 S1b domain in complex with WNb 293 and WNb 317 Human coronavirus OC43; Vicugna pacos vicugna pacos human coronavirus oc43 Pymm, P., Feng, J., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.266 0.227 False True IGHV1 NA NA None None None None None 8uh3 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 05/01/24 Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Setiptiline Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wacker, D., Parpounas, A.K., Warren, A.L., Zilberg, G. 3.31 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8vzn B C 0 A protein NA feline leukemia virus subgroup c cellular receptor 2 TRANSPORT PROTEIN 05/01/24 Cryo-EM structure of FLVCR2 in the inward-facing state with choline bound Mus musculus; synthetic construct synthetic construct synthetic construct mus musculus Cater, R.J., Mancia, F. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vzo B D 0 A protein NA feline leukemia virus subgroup c cellular receptor 2 TRANSPORT PROTEIN 05/01/24 Cryo-EM structure of FLVCR2 in the outward-facing state with choline bound Mus musculus; synthetic construct synthetic construct synthetic construct mus musculus Cater, R.J., Mancia, F. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8c67 H L 0 NA NA NA NA IMMUNE SYSTEM 04/24/24 Crystal structure of Ab25 Fab Homo sapiens homo sapiens homo sapiens Nyblom, M., Izadi, A., Tang, D., Bahnan, W., Happonen, L., Malmstroem, J., Shannon, O., Malmstroem, L., Nordenfelt, P. 1.88 X-RAY DIFFRACTION 0.255 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8c67 A B 0 NA NA NA NA IMMUNE SYSTEM 04/24/24 Crystal structure of Ab25 Fab Homo sapiens homo sapiens homo sapiens Nyblom, M., Izadi, A., Tang, D., Bahnan, W., Happonen, L., Malmstroem, J., Shannon, O., Malmstroem, L., Nordenfelt, P. 1.88 X-RAY DIFFRACTION 0.255 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8c67 C D 0 NA NA NA NA IMMUNE SYSTEM 04/24/24 Crystal structure of Ab25 Fab Homo sapiens homo sapiens homo sapiens Nyblom, M., Izadi, A., Tang, D., Bahnan, W., Happonen, L., Malmstroem, J., Shannon, O., Malmstroem, L., Nordenfelt, P. 1.88 X-RAY DIFFRACTION 0.255 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8c67 E F 0 NA NA NA NA IMMUNE SYSTEM 04/24/24 Crystal structure of Ab25 Fab Homo sapiens homo sapiens homo sapiens Nyblom, M., Izadi, A., Tang, D., Bahnan, W., Happonen, L., Malmstroem, J., Shannon, O., Malmstroem, L., Nordenfelt, P. 1.88 X-RAY DIFFRACTION 0.255 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8iuy B C 0 A protein NA hemagglutinin MEMBRANE PROTEIN/IMMUNE SYSTEM 04/24/24 H7N9 HA-1H9 Fab H7N9 subtype; Mus musculus mus musculus mus musculus h7n9 subtype Zhao, B.B., Sun, Z.Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV15 Kappa None None None None None 8iuz B C 0 A protein NA hemagglutinin MEMBRANE PROTEIN/IMMUNE SYSTEM 04/24/24 H7N9 HA-2D7 Fab H7N9 subtype; Mus musculus mus musculus mus musculus h7n9 subtype Zhao, B.B., Sun, Z.Z. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV15 Kappa None None None None None 8iv0 B C 0 A protein NA hemagglutinin MEMBRANE PROTEIN/IMMUNE SYSTEM 04/24/24 H7N9 HA-C4H4 Fab H7N9 subtype; Mus musculus mus musculus mus musculus h7n9 subtype Zhao, B.B., Sun, Z.Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ruu B C 0 X protein NA interleukin-17f IMMUNOSUPPRESSANT 04/24/24 Fabs derived from bimekizumab in complex with IL-17F Homo sapiens homo sapiens homo sapiens homo sapiens Adams, R., Lawson, A.D.G. 2.81 X-RAY DIFFRACTION 0.242 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8ruu H L 0 Y protein NA interleukin-17f IMMUNOSUPPRESSANT 04/24/24 Fabs derived from bimekizumab in complex with IL-17F Homo sapiens homo sapiens homo sapiens homo sapiens Adams, R., Lawson, A.D.G. 2.81 X-RAY DIFFRACTION 0.242 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8sgi H L 0 A protein NA sodium/calcium exchanger 1 TRANSPORT PROTEIN 04/24/24 Cryo-EM structure of human NCX1 in complex with SEA0400 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Xue, J., Jiang, Y. 2.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGLV1 Lambda None None None None None 8sjk B A 0 A Hapten CFF CAFFEINE IMMUNE SYSTEM 04/24/24 Pembrolizumab Caffeine crystal Homo sapiens homo sapiens homo sapiens homo sapiens Larpent, P., Codan, L., Bothe, J.R., Stueber, D., Reichert, P., Fischmann, T., Su, Y., Pabit, S., Gupta, S., Iuzzolino, L., Cote, A. 2.22 X-RAY DIFFRACTION 0.238 0.186 False True IGHV1 IGKV3 Kappa None None None None None 8tqi C D 0 A protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/24/24 Hemagglutinin-neuraminidase from Human parainfluenza virus type 3: complex with rPIV3-23 and rPIV3-28 Fabs Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Otrelo-Cardoso, A.R., Jardetzky, T.S. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tqi E F 0 B protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/24/24 Hemagglutinin-neuraminidase from Human parainfluenza virus type 3: complex with rPIV3-23 and rPIV3-28 Fabs Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Otrelo-Cardoso, A.R., Jardetzky, T.S. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8tqi H L 0 B protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/24/24 Hemagglutinin-neuraminidase from Human parainfluenza virus type 3: complex with rPIV3-23 and rPIV3-28 Fabs Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Otrelo-Cardoso, A.R., Jardetzky, T.S. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tqi I J 0 A protein NA hemagglutinin-neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 04/24/24 Hemagglutinin-neuraminidase from Human parainfluenza virus type 3: complex with rPIV3-23 and rPIV3-28 Fabs Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Otrelo-Cardoso, A.R., Jardetzky, T.S. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8tqk D E 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN, IMMUNE SYSTEM 04/24/24 Human parainfluenza virus type 3 prefusion F trimer in complex with rPIV3-18 Fab Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Otrelo-Cardoso, A.R., Jardetzky, T.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tqk F G 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN, IMMUNE SYSTEM 04/24/24 Human parainfluenza virus type 3 prefusion F trimer in complex with rPIV3-18 Fab Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Otrelo-Cardoso, A.R., Jardetzky, T.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tqk H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN, IMMUNE SYSTEM 04/24/24 Human parainfluenza virus type 3 prefusion F trimer in complex with rPIV3-18 Fab Homo sapiens; Human respirovirus 3 homo sapiens homo sapiens human respirovirus 3 Otrelo-Cardoso, A.R., Jardetzky, T.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8x16 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/24/24 Cryo-EM structure of adenosine receptor A3AR bound to CF101 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus bos taurus | rattus norvegicus Cai, H., Xu, Y., Xu, H.E. 3.29 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8x17 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/24/24 Cryo-EM structure of adenosine receptor A3AR bound to CF102 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus bos taurus | rattus norvegicus Cai, H., Xu, Y., Xu, H.E. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xea A B 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 XBB.1.5 spike protein in complex with BD55-1205 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xea G I 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 XBB.1.5 spike protein in complex with BD55-1205 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xea H J 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 XBB.1.5 spike protein in complex with BD55-1205 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8xi6 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/24/24 SARS-CoV-2 Omicron BQ.1.1 Variant Spike Protein Complexed with MO11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ishimaru, H., Nishimura, M., Shigematsu, H., Marini, M.I., Hasegawa, N., Takamiya, R., Iwata, S., Mori, Y. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8xi6 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/24/24 SARS-CoV-2 Omicron BQ.1.1 Variant Spike Protein Complexed with MO11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ishimaru, H., Nishimura, M., Shigematsu, H., Marini, M.I., Hasegawa, N., Takamiya, R., Iwata, S., Mori, Y. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8xi6 H I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/24/24 SARS-CoV-2 Omicron BQ.1.1 Variant Spike Protein Complexed with MO11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ishimaru, H., Nishimura, M., Shigematsu, H., Marini, M.I., Hasegawa, N., Takamiya, R., Iwata, S., Mori, Y. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8yy8 N NA 0 A | B protein | protein NA | NA mingas | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/24/24 Fzd7 -Gs complex Homo sapiens homo sapiens homo sapiens | homo sapiens Chen, B., Xu, L., Han, G.W., Xu, F. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9auc N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/24/24 Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Wootten, D.L., Sexton, P.M. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9bei H L 0 B protein NA heat-labile enterotoxin b chain MEMBRANE PROTEIN/IMMUNE SYSYTEM 01/08/09 Cryo-EM structure of synthetic claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-2, and Nanobody Clostridium perfringens; SYNTHETIC CONSTRUCT clostridium perfringens Vecchio, A.J. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 9bei K NA 0 NA NA NA NA MEMBRANE PROTEIN/IMMUNE SYSYTEM 01/08/09 Cryo-EM structure of synthetic claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-2, and Nanobody Clostridium perfringens; SYNTHETIC CONSTRUCT Vecchio, A.J. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tfh H L 0 B protein NA ricin b chain TOXIN/IMMUNE SYSTEM 04/17/24 Ricin in complex with Fab JB4 Mus musculus; Ricinus communis mus musculus mus musculus ricinus communis Rudolph, M.J., Mantis, N. 3.29 X-RAY DIFFRACTION 0.334 0.274 False True IGHV1 IGKV19 Kappa None None None None None 8tfl H L 0 B protein NA ricin b chain TOXIN 04/17/24 Ricin in complex with Fab SylH3 Mus musculus; Ricinus communis mus musculus mus musculus ricinus communis Rudolph, M.J., Mantis, N. 2.89 X-RAY DIFFRACTION 0.287 0.233 False True IGHV1 IGKV19 Kappa None None None None None 9axf H h 0 A protein NA guanine nucleotide-binding protein g(i) subunit alpha-1,adenylate cyclase-stimulating g alpha protein MEMBRANE PROTEIN 04/17/24 Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent Homo sapiens; Lama glama; Mus musculus mus musculus homo sapiens Zuo, H., Park, J., Frangaj, A., Ye, J., Lu, G., Manning, J.J., Asher, W.B., Lu, Z., Hu, G., Wang, L., Mendez, J., Eng, E., Zhang, Z., Lin, X., Grasucci, R., Hendrickson, W.A., Clarke, O.B., Javitch, J.A., Conigrave, A.D., Fan, Q.R. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9axf N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,adenylate cyclase-stimulating g alpha protein | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/17/24 Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Zuo, H., Park, J., Frangaj, A., Ye, J., Lu, G., Manning, J.J., Asher, W.B., Lu, Z., Hu, G., Wang, L., Mendez, J., Eng, E., Zhang, Z., Lin, X., Grasucci, R., Hendrickson, W.A., Clarke, O.B., Javitch, J.A., Conigrave, A.D., Fan, Q.R. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8b8i A NA 0 I peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8b8i B NA 0 J peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8b8i C NA 0 K peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8b8i D NA 0 L peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8b8i E NA 0 M peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8b8i F NA 0 N peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8b8i G NA 0 O peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8b8i H NA 0 P peptide NA synaptotagmin-1 PEPTIDE BINDING PROTEIN 04/17/24 Nanobody (NbLumSyt1) bound to human Syt1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Liu, H., Scaletti, E., Stenmark, P. 2.75 X-RAY DIFFRACTION 0.298 0.263 False True IGHV1 NA NA None None None None None 8f2x H L 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 04/17/24 Crystal structure of antibody WRAIR-2123 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, G.M. 3.501 X-RAY DIFFRACTION 0.324 0.245 False True IGHV3 IGKV1 Kappa None None None None None 8j23 F f 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/17/24 Cryo-EM structure of FFAR2 complex in apo state Homo sapiens homo sapiens homo sapiens | homo sapiens Tai, L., Li, F., Sun, X., Tang, W., Wang, J. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jg5 C D 0 A protein NA vp1 VIRUS 04/17/24 Cryo-EM structure of the GI.4 Chiba VLP complexed with the CV-1A1 Fv-clasp Homo sapiens; Norovirus homo sapiens homo sapiens norovirus Hosaka, T., Katsura, K., Kimura-Someya, T., Someya, Y., Shirouzu, M. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8jg5 E F 0 B protein NA vp1 VIRUS 04/17/24 Cryo-EM structure of the GI.4 Chiba VLP complexed with the CV-1A1 Fv-clasp Homo sapiens; Norovirus homo sapiens homo sapiens norovirus Hosaka, T., Katsura, K., Kimura-Someya, T., Someya, Y., Shirouzu, M. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8khc F G 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/17/24 SARS-CoV-2 Omicron spike in complex with 5817 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cao, L., Wang, X. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8khc H J 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/17/24 SARS-CoV-2 Omicron spike in complex with 5817 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cao, L., Wang, X. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8khd H J 0 C protein NA spike protein s1 VIRAL PROTEIN 04/17/24 The interface structure of Omicron RBD binding to 5817 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cao, L., Wang, X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8sef H L 0 NA NA NA NA IMMUNE SYSTEM 04/17/24 Crystal structure of Cy137C02, a monoclonal antibody isolated from macaques immunized with an Epstein-Barr virus glycoprotein 350 (gp350) nanoparticle vaccine Macaca fascicularis macaca fascicularis macaca fascicularis Joyce, M.G., Jensen, J.L., Chen, W.H., Kanekiyo, M. 2.47 X-RAY DIFFRACTION 0.264 0.222 False True IGHV4 IGLV1 Lambda None None None None None 8sga H L 0 B carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 04/17/24 Crystal structure of 770E11, a monoclonal antibody isolated from a human Epstein-Barr virus seropositive donor Homo sapiens homo sapiens homo sapiens Chen, W.H., Jensen, J.L., Joyce, M.G. 1.9 X-RAY DIFFRACTION 0.242 0.206 False True IGHV4 IGLV1 Lambda None None None None None 8sgg A B 0 NA NA NA NA IMMUNE SYSTEM 04/17/24 Crystal structure of Cy137D09, a monoclonal antibody isolated from macaques immunized with an Epstein-Barr virus glycoprotein 350 (gp350) nanoparticle vaccine Macaca fascicularis macaca fascicularis macaca fascicularis Joyce, M.G., Jensen, J.L., Chen, W.H., Kanekiyo, M. 2.03 X-RAY DIFFRACTION 0.247 0.191 False True IGHV4 IGLV5 Lambda None None None None None 8sgg C D 0 NA NA NA NA IMMUNE SYSTEM 04/17/24 Crystal structure of Cy137D09, a monoclonal antibody isolated from macaques immunized with an Epstein-Barr virus glycoprotein 350 (gp350) nanoparticle vaccine Macaca fascicularis macaca fascicularis macaca fascicularis Joyce, M.G., Jensen, J.L., Chen, W.H., Kanekiyo, M. 2.03 X-RAY DIFFRACTION 0.247 0.191 False True IGHV4 IGLV5 Lambda None None None None None 8sgn H L 0 G protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/24 Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy651H02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine Human herpesvirus 4; Macaca fascicularis macaca fascicularis macaca fascicularis human herpesvirus 4 Joyce, M.G., Jensen, J.L., Chen, W.H., Kanekiyo, M. 2.2 X-RAY DIFFRACTION 0.237 0.193 False True IGHV4 IGLV2 Lambda None None None None None 8sic A B 0 E protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/24 Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine Human herpesvirus 4; Macaca fascicularis macaca fascicularis macaca fascicularis human herpesvirus 4 Joyce, M.G., Jensen, J.L., Chen, W.H., Kanekiyo, M. 2.76 X-RAY DIFFRACTION 0.295 0.246 False True IGHV4 IGLV1 Lambda None None None None None 8sic H L 0 G protein NA envelope glycoprotein gp350 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/24 Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine Human herpesvirus 4; Macaca fascicularis macaca fascicularis macaca fascicularis human herpesvirus 4 Joyce, M.G., Jensen, J.L., Chen, W.H., Kanekiyo, M. 2.76 X-RAY DIFFRACTION 0.295 0.246 False True IGHV4 IGLV1 Lambda None None None None None 8y6h C B 0 A protein NA atp-dependent translocase abcb1,mneongreen MEMBRANE PROTEIN 04/17/24 P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hamaguchi-Suzuki, N., Adachi, N., Moriya, T., Kawasaki, M., Suzuki, K., Anzai, N., Senda, T., Murata, T. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8y6i C B 0 A protein NA atp-dependent translocase abcb1,mneongreen MEMBRANE PROTEIN 04/17/24 P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hamaguchi-Suzuki, N., Adachi, N., Moriya, T., Kawasaki, M., Suzuki, K., Anzai, N., Senda, T., Murata, T. 2.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9ayf H h 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 04/17/24 Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Zuo, H., Park, J., Frangaj, A., Ye, J., Lu, G., Manning, J.J., Asher, W.B., Lu, Z., Hu, G., Wang, L., Mendez, J., Eng, E., Zhang, Z., Lin, X., Grasucci, R., Hendrickson, W.A., Clarke, O.B., Javitch, J.A., Conigrave, A.D., Fan, Q.R. 3.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8oni H L 0 B | I peptide | peptide NA | NA insulin b chain | insulin a chain HORMONE 04/10/24 Human insulin in complex with the analytical antibody S1 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.3 X-RAY DIFFRACTION 0.238 0.197 False True IGHV1 IGKV4 Kappa None None None None None 8oni C D 0 F | A peptide | peptide NA | NA insulin b chain | insulin a chain HORMONE 04/10/24 Human insulin in complex with the analytical antibody S1 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.3 X-RAY DIFFRACTION 0.238 0.197 False True IGHV1 IGKV4 Kappa None None None None None 8iz4 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/10/24 Lysophosphatidylserine receptor GPR34-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Gong, W., Liu, G., Li, X., Zhang, X. 2.93 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8omz B NA 0 A protein NA uracil permease MEMBRANE PROTEIN 04/10/24 Wide inward-open unliganded UraA in complex with a conformation-selective synthetic nanobody Escherichia coli O157:H7; synthetic construct synthetic construct escherichia coli o157 Kuhn, B.T., Geertsma, E.R. 3.5 X-RAY DIFFRACTION 0.260 0.241 False True IGHV1 NA NA None None None None None 8omz D NA 0 C protein NA uracil permease MEMBRANE PROTEIN 04/10/24 Wide inward-open unliganded UraA in complex with a conformation-selective synthetic nanobody Escherichia coli O157:H7; synthetic construct synthetic construct escherichia coli o157 Kuhn, B.T., Geertsma, E.R. 3.5 X-RAY DIFFRACTION 0.260 0.241 False True IGHV1 NA NA None None None None None 8onk H L 0 B peptide NA insulin b chain HORMONE 04/10/24 Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Johansson, E. 3.403 X-RAY DIFFRACTION 0.311 0.258 False True IGHV1 IGKV4 Kappa None None None None None 8onk C E 0 A peptide NA insulin b chain HORMONE 04/10/24 Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Johansson, E. 3.403 X-RAY DIFFRACTION 0.311 0.258 False True IGHV1 IGKV4 Kappa None None None None None 8onk G F 0 I peptide NA insulin a chain HORMONE 04/10/24 Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Johansson, E. 3.403 X-RAY DIFFRACTION 0.311 0.258 False True IGHV9 IGKV4 Kappa None None None None None 8onk K J 0 D peptide NA insulin a chain HORMONE 04/10/24 Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Johansson, E. 3.403 X-RAY DIFFRACTION 0.311 0.258 False True IGHV9 IGKV4 Kappa None None None None None 8oo1 B NA 0 A protein NA uracil permease MEMBRANE PROTEIN 04/10/24 Wide inward-open liganded UraA in complex with a conformation-selective synthetic nanobody Escherichia coli O157:H7; synthetic construct synthetic construct escherichia coli o157 Kuhn, B.T., Geertsma, E.R. 3.7 X-RAY DIFFRACTION 0.294 0.271 False True IGHV1 NA NA None None None None None 8oo1 D NA 0 C protein NA uracil permease MEMBRANE PROTEIN 04/10/24 Wide inward-open liganded UraA in complex with a conformation-selective synthetic nanobody Escherichia coli O157:H7; synthetic construct synthetic construct escherichia coli o157 Kuhn, B.T., Geertsma, E.R. 3.7 X-RAY DIFFRACTION 0.294 0.271 False True IGHV1 NA NA None None None None None 8uiw A B 0 R nucleic-acid NA yjdf rna (r. gauvreauii) RNA 04/10/24 yjdF riboswitch from R. gauvreauii in complex with chelerythrine bound to Fab BL3-6 S97N Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus ruminococcus gauvreauii Krochmal, D., Lewicka, A., Piccirilli, J.A. 2.77 X-RAY DIFFRACTION 0.231 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8uiw H L 0 N nucleic-acid NA yjdf rna (r. gauvreauii) RNA 04/10/24 yjdF riboswitch from R. gauvreauii in complex with chelerythrine bound to Fab BL3-6 S97N Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus ruminococcus gauvreauii Krochmal, D., Lewicka, A., Piccirilli, J.A. 2.77 X-RAY DIFFRACTION 0.231 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8uky H L 0 C protein NA bcl-2 homologous antagonist/killer APOPTOSIS/INHIBITOR 04/10/24 Crystal structure of BAK in complex with inhibiting antibody 14G6 Homo sapiens homo sapiens homo sapiens homo sapiens Miller, M.S., Czabotar, P.E. 2.398 X-RAY DIFFRACTION 0.252 0.215 False True IGHV1 IGKV6 Kappa None None None None None 8uky B A 0 D protein NA bcl-2 homologous antagonist/killer APOPTOSIS/INHIBITOR 04/10/24 Crystal structure of BAK in complex with inhibiting antibody 14G6 Homo sapiens homo sapiens homo sapiens homo sapiens Miller, M.S., Czabotar, P.E. 2.398 X-RAY DIFFRACTION 0.252 0.215 False True IGHV1 IGKV6 Kappa None None None None None 8uta A B 0 R nucleic-acid NA yjdf rna (r. gauvreauii) RNA 04/10/24 yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus ruminococcus gauvreauii Krochmal, D., Lewicka, A., Piccirilli, J.A. 3.05 X-RAY DIFFRACTION 0.269 0.224 False True IGHV3 IGKV1 Kappa None None None None None 8uta H L 0 N nucleic-acid NA yjdf rna (r. gauvreauii) RNA 04/10/24 yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus ruminococcus gauvreauii Krochmal, D., Lewicka, A., Piccirilli, J.A. 3.05 X-RAY DIFFRACTION 0.269 0.224 False True IGHV3 IGKV1 Kappa None None None None None 8v52 D C 0 B protein NA transforming growth factor beta-3 CYTOKINE/IMMUNE SYSTEM 04/10/24 Crystal structure of 2A10 Fab bound to Human TGF-beta3 Homo sapiens homo sapiens homo sapiens homo sapiens Yin, J., Lupardus, P.J. 2.5 X-RAY DIFFRACTION 0.269 0.221 False True IGHV3 IGKV1 Kappa None None None None None 8v52 F E 0 A protein NA transforming growth factor beta-3 CYTOKINE/IMMUNE SYSTEM 04/10/24 Crystal structure of 2A10 Fab bound to Human TGF-beta3 Homo sapiens homo sapiens homo sapiens homo sapiens Yin, J., Lupardus, P.J. 2.5 X-RAY DIFFRACTION 0.269 0.221 False True IGHV3 IGKV1 Kappa None None None None None 8v7o H L 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 04/10/24 Fab fragment of human mAb #58 in complex with computationally optimized broadly reactive H1 influenza hemagglutinin X6 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Nagashima, K.A., Mousa, J.J. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8v7o I M 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 04/10/24 Fab fragment of human mAb #58 in complex with computationally optimized broadly reactive H1 influenza hemagglutinin X6 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Nagashima, K.A., Mousa, J.J. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8v7o J N 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 04/10/24 Fab fragment of human mAb #58 in complex with computationally optimized broadly reactive H1 influenza hemagglutinin X6 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Nagashima, K.A., Mousa, J.J. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8xof N NA 0 A | B protein | protein NA | NA g protein subunit q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of Lys05 bound GPR30-Gq complex structure Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, H., Xu, P., Xu, H.E. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xog E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/10/24 Cryo-EM structure of apo-GPR30-Gq complex structure Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Liu, H., Xu, P., Xu, H.E. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xoh E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/10/24 Cryo-EM structure of GPR30-Gq complex structure in the presence of E2 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Liu, H., Xu, P., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xoi E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/10/24 Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Liu, H., Xu, P., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xoj E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/10/24 Cryo-EM structure of GPR30-Gq complex structure in the presence of G-1 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Liu, H., Xu, P., Xu, H.E. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 9eq3 H L 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Structure of IgE HMM5 bound to FceRIa cryo-EM class 8 Homo sapiens homo sapiens homo sapiens Andersen, G.R., Jensen, R.K. 6.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9eq3 X Y 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Structure of IgE HMM5 bound to FceRIa cryo-EM class 8 Homo sapiens homo sapiens homo sapiens Andersen, G.R., Jensen, R.K. 6.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8j6i H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/03/24 Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 Homo sapiens homo sapiens homo sapiens | homo sapiens Yuan, Q., Zhu, S., Duan, J., Xu, H.E., Duan, X. 2.92 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j6l H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin Homo sapiens homo sapiens homo sapiens | homo sapiens Yuan, Q., Zhu, S., Duan, J., Xu, H.E., Duan, X. 3.05 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8oi2 B NA 0 A protein NA albumin IMMUNE SYSTEM 04/03/24 Crystal structure of Alb1 megabody in complex with human serum albumin Helicobacter pylori G27; Homo sapiens helicobacter pylori g27 homo sapiens De Felice, S., Zoia, G., Romanyuk, Z., Pardon, E., Steyaert, J., Angelini, A., Cendron, L. 3.3 X-RAY DIFFRACTION 0.277 0.226 False True IGHV3 NA NA None None None None None 8p6i H L 0 A peptide NA mucin-1 IMMUNE SYSTEM 04/03/24 Crystal structure of the 139H2 Fab fragment bound to Muc1 peptide epitope Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Beugelink, J.W., Peng, W., Siborova, M., Pronker, M.F., Snijder, J., Janssen, B.J.C. 2.5 X-RAY DIFFRACTION 0.254 0.203 False True IGHV1 IGKV8 Kappa None None None None None 8p6i h l 0 a peptide NA unknown IMMUNE SYSTEM 04/03/24 Crystal structure of the 139H2 Fab fragment bound to Muc1 peptide epitope Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Beugelink, J.W., Peng, W., Siborova, M., Pronker, M.F., Snijder, J., Janssen, B.J.C. 2.5 X-RAY DIFFRACTION 0.254 0.203 False False IGHV1 IGKV8 Kappa None None None None None 8pij B NA 0 A protein NA pilin PROTEIN FIBRIL 04/03/24 Neisseria meningitidis Type IV pilus SB-GATDH variant bound to the C24 nanobody Neisseria meningitidis 8013; Vicugna pacos vicugna pacos neisseria meningitidis 8013 Fernandez-Martinez, D., Dumenil, G. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8piz B NA 0 A protein NA pilin PROTEIN FIBRIL 04/03/24 Neisseria meningitidis Type IV pilus SB-DATDH variant bound to the C24 nanobody Neisseria meningitidis 8013; Vicugna pacos vicugna pacos neisseria meningitidis 8013 Fernandez-Martinez, D., Dumenil, G. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pjp C NA 0 A protein NA pilin PROTEIN FIBRIL 04/03/24 Neisseria meningitidis PilE, SB-GATDH variant, bound to the F10 nanobody Neisseria meningitidis 8013; Vicugna pacos vicugna pacos neisseria meningitidis 8013 Fernandez-Martinez, D., Dumenil, G. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnu J NA 0 G protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase bound to benzylamine inhibitor Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, V., Li, X. 2.12 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnu K NA 0 H protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase bound to benzylamine inhibitor Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, V., Li, X. 2.12 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnu L NA 0 I protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase bound to benzylamine inhibitor Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, V., Li, X. 2.12 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnu D NA 0 A protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase bound to benzylamine inhibitor Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, V., Li, X. 2.12 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnu E NA 0 B protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase bound to benzylamine inhibitor Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, V., Li, X. 2.12 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnu F NA 0 C protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase bound to benzylamine inhibitor Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, V., Li, X. 2.12 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnv D NA 0 A protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, B., Li, X. 2.048 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnv E NA 0 B protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, B., Li, X. 2.048 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnv F NA 0 C protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, B., Li, X. 2.048 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnv J NA 0 G protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, B., Li, X. 2.048 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnv K NA 0 H protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, B., Li, X. 2.048 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pnv L NA 0 I protein NA styrene oxide isomerase MEMBRANE PROTEIN 04/03/24 Cryo-EM structure of styrene oxide isomerase Pseudomonas sp. VLB120; Vicugna pacos vicugna pacos pseudomonas sp. vlb120 Khanppnavar, B., Korkhov, B., Li, X. 2.048 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8qzr H L 0 C protein NA spike protein s1 VIRAL PROTEIN 04/03/24 SARS-CoV-2 delta RBD complexed with BA.4/5-9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.77 X-RAY DIFFRACTION 0.300 0.251 False True IGHV1 IGKV3 Kappa None None None None None 8qzr A B 0 E protein NA spike protein s1 VIRAL PROTEIN 04/03/24 SARS-CoV-2 delta RBD complexed with BA.4/5-9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.77 X-RAY DIFFRACTION 0.300 0.251 False True IGHV1 IGKV3 Kappa None None None None None 8rmo H L 0 F peptide NA flag-tag IMMUNE SYSTEM 04/03/24 Crystal structure of anti-FLAG M2 Fab fragment bound to FLAG-tag peptide epitope Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Beugelink, J.W., Janssen, B.J.C., Pronker, M.F. 1.163 X-RAY DIFFRACTION 0.186 0.158 False True IGHV1 IGKV1 Kappa None None None None None 8vrr A a 0 NA NA NA NA PEPTIDE BINDING PROTEIN,IMMUNE SYSTEM 04/03/24 4H11-scFv antibody Mus musculus mus musculus Lee, K., Perry, K., Yeku, O.O., Spriggs, D.R. 2.36 X-RAY DIFFRACTION 0.251 0.225 True True unknown unknown unknown None None None None None 8vrs C c 0 B protein NA maltose/maltodextrin-binding periplasmic protein,mucin-16 ONCOPROTEIN/IMMUNE SYSTEM 04/03/24 Mucin 16 peptide fused to MBP in complex with 4H11-scFv antibody Escherichia coli; Homo sapiens; Mus musculus mus musculus escherichia coli, homo sapiens Lee, K., Perry, K., Yeku, O.O., Spriggs, D.R. 2.47 X-RAY DIFFRACTION 0.237 0.192 True True unknown unknown unknown None None None None None 8vrs D d 0 A protein NA maltose/maltodextrin-binding periplasmic protein,mucin-16 ONCOPROTEIN/IMMUNE SYSTEM 04/03/24 Mucin 16 peptide fused to MBP in complex with 4H11-scFv antibody Escherichia coli; Homo sapiens; Mus musculus mus musculus escherichia coli, homo sapiens Lee, K., Perry, K., Yeku, O.O., Spriggs, D.R. 2.47 X-RAY DIFFRACTION 0.237 0.192 True True unknown unknown unknown None None None None None 8vy7 D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/08/09 CryoEM structure of Gi-coupled TAS2R14 with cholesterol and an intracellular tastant Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Kim, Y., Gumpper, R.H., Roth, B.L. 2.68 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8vy9 D d 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/08/09 CryoEM structure of Ggust-coupled TAS2R14 with cholesterol and an intracellular tastant Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Kim, Y., Gumpper, R.H., Roth, B.L. 2.88 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8x2k E e 0 B | C protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/03/24 a lipid receptor complex structure Homo sapiens homo sapiens homo sapiens | homo sapiens Geng, C., Yang, D., Jun, X. 3.03 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xgr N NA 0 G | B protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2,egt-alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PEPTIDE BINDING PROTEIN/IMMUNE SYSTEM 04/03/24 ETB-eGt complex bound to endothelin-1 Bos taurus; Homo sapiens; Lama glama; Rattus rattus; SYNTHETIC CONSTRUCT lama glama bos taurus | rattus rattus Oshima, H.S., Sano, F.K., Akasaka, H., Iwama, A., Shihoya, W., Nureki, O. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 9eq4 H L 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Structure of IgE HMM5 bound to FceRIa cryo-EM class 5 Homo sapiens homo sapiens homo sapiens Andersen, G.R., Jensen, R.K. 8.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 9eq4 X Y 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Structure of IgE HMM5 bound to FceRIa cryo-EM class 5 Homo sapiens homo sapiens homo sapiens Andersen, G.R., Jensen, R.K. 8.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8iqp H L 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M9 Fv-clasp fragment with PEG (co-crystallization with PEG3350) Mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 1.76 X-RAY DIFFRACTION 0.246 0.205 False True IGHV5 IGKV1 Kappa None None None None None 8iqp h l 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M9 Fv-clasp fragment with PEG (co-crystallization with PEG3350) Mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 1.76 X-RAY DIFFRACTION 0.246 0.205 False False IGHV5 IGKV1 Kappa None None None None None 8iqq H L 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M9 Fv-clasp fragment with PEG (co-crystallization with PEG2000MME) Mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 2.02 X-RAY DIFFRACTION 0.243 0.199 False True IGHV5 IGKV1 Kappa None None None None None 8iqq h l 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M9 Fv-clasp fragment with PEG (co-crystallization with PEG2000MME) Mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 2.02 X-RAY DIFFRACTION 0.243 0.199 False False IGHV5 IGKV1 Kappa None None None None None 8iqs H L 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M11 Fv-clasp fragment with PEG (co-crystallization with PEG3350) Mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 2.16 X-RAY DIFFRACTION 0.270 0.236 False True IGHV6 IGKV1 Kappa None None None None None 8iqs h l 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal structure of Anti-PEG antibody M11 Fv-clasp fragment with PEG (co-crystallization with PEG3350) Mus musculus mus musculus mus musculus Mori, T., Teramoto, T., Liu, Y., Mori, T., Kakuta, Y. 2.16 X-RAY DIFFRACTION 0.270 0.236 False False IGHV6 IGKV1 Kappa None None None None None 8tq7 F G 0 C protein NA h-2 class i histocompatibility antigen, d-d alpha chain IMMUNE SYSTEM 03/20/24 Crystal structure of Fab.34.2.12 in complex with MHC-I (H2-Dd) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Jiang, J., Boyd, L.F., Natarajan, K., Margulies, D.H. 2.8 X-RAY DIFFRACTION 0.271 0.225 False True IGHV1 IGKV6 Kappa None None None None None 8tq7 H L 0 A protein NA h-2 class i histocompatibility antigen, d-d alpha chain IMMUNE SYSTEM 03/20/24 Crystal structure of Fab.34.2.12 in complex with MHC-I (H2-Dd) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Jiang, J., Boyd, L.F., Natarajan, K., Margulies, D.H. 2.8 X-RAY DIFFRACTION 0.271 0.225 False True IGHV1 IGKV6 Kappa None None None None None 8tq8 H L 0 A protein NA h-2 class i histocompatibility antigen, d-d alpha chain IMMUNE SYSTEM 03/20/24 Crystal structure of Fab.34.5.8 in complex with MHC-I (H2-Dd) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Jiang, J., Boyd, L.F., Natarajan, K., Margulies, D.H. 2.69 X-RAY DIFFRACTION 0.243 0.201 False True IGHV1 IGKV3 Kappa None None None None None 8tq8 F G 0 C protein NA h-2 class i histocompatibility antigen, d-d alpha chain IMMUNE SYSTEM 03/20/24 Crystal structure of Fab.34.5.8 in complex with MHC-I (H2-Dd) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Jiang, J., Boyd, L.F., Natarajan, K., Margulies, D.H. 2.69 X-RAY DIFFRACTION 0.243 0.201 False True IGHV1 IGKV3 Kappa None None None None None 8tq9 H L 0 B | A protein | protein NA | NA beta-2-microglobulin | h-2 class i histocompatibility antigen, d-d alpha chain IMMUNE SYSTEM 03/20/24 Crystal structure of Fab.S19.8 in complex with MHC-I (H2-Dd) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus | mus musculus Jiang, J., Boyd, L.F., Natarajan, K., Margulies, D.H. 2.9 X-RAY DIFFRACTION 0.240 0.187 False True IGHV1 IGKV17 Kappa None None None None None 8tqa H L 0 A protein NA h-2 class i histocompatibility antigen, d-b alpha chain IMMUNE SYSTEM 03/20/24 Crystal structure of Fab.28.14.8 in complex with MHC-I (H2-Db) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Jiang, J., Boyd, L.F., Natarajan, K., Margulies, D.H. 2.6 X-RAY DIFFRACTION 0.253 0.181 False True IGHV1 IGKV10 Kappa None None None None None 8rqf H L 0 B | A peptide | protein NA | NA polymerase | sodium/bile acid cotransporter TRANSPORT PROTEIN 03/27/24 Cryo-EM structure of human NTCP-Bulevirtide complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis b virus genotype c | homo sapiens Liu, H., Zakrzewicz, D., Nosol, K., Irobalieva, R.N., Mukherjee, S., Bang-Soerensen, R., Goldmann, N., Kunz, S., Rossi, L., Kossiakoff, A.A., Urban, S., Glebe, D., Geyer, J., Locher, K.P. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8rqf K NA 0 NA NA NA NA TRANSPORT PROTEIN 03/27/24 Cryo-EM structure of human NTCP-Bulevirtide complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama Liu, H., Zakrzewicz, D., Nosol, K., Irobalieva, R.N., Mukherjee, S., Bang-Soerensen, R., Goldmann, N., Kunz, S., Rossi, L., Kossiakoff, A.A., Urban, S., Glebe, D., Geyer, J., Locher, K.P. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tnt E D 0 A | B protein | protein NA | NA envelope glycoprotein h | envelope glycoprotein l IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gH/gL/gp42 in complex with antibodies F-2-1 and 769C2 Epstein-Barr virus; Homo sapiens; Mus musculus homo sapiens homo sapiens epstein-barr virus | epstein-barr virus Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 3.15 X-RAY DIFFRACTION 0.287 0.255 False True IGHV3 IGLV2 Lambda None None None None None 8tnt G F 0 C protein NA glycoprotein 42 IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gH/gL/gp42 in complex with antibodies F-2-1 and 769C2 Epstein-Barr virus; Homo sapiens; Mus musculus mus musculus mus musculus epstein-barr virus Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 3.15 X-RAY DIFFRACTION 0.287 0.255 False True IGHV4 IGKV3 Kappa None None None None None 8iu2 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/27/24 Cryo-EM structure of Long-wave-sensitive opsin 1 Bos taurus; Homo sapiens homo sapiens homo sapiens | homo sapiens Peng, Q., Cheng, X.Y., Li, J., Lu, Q.Y., Li, Y.Y., Zhang, J. 3.35 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j6f H L 0 I | B protein | peptide NA | NA interleukin-6 receptor subunit alpha | il6r-d2 peptide IMMUNE SYSTEM 03/27/24 Cryo-EM structure of the Tocilizumab Fab/IL-6R complex Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens She, J., Chen, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8jtw B NA 0 A protein NA solute carrier family 22 member 1 MEMBRANE PROTEIN 03/27/24 hOCT1 in complex with nb5660 in inward facing partially open 1 conformation Homo sapiens; Lama glama lama glama homo sapiens Zhang, S., Zhu, A., Kong, F., Chen, J., Lan, B., He, G., Gao, K., Cheng, L., Yan, C., Chen, L., Liu, X. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jtx B NA 0 A protein NA solute carrier family 22 member 1 MEMBRANE PROTEIN 03/27/24 hOCT1 in complex with nb5660 in inward facing fully open conformation Homo sapiens; Lama glama lama glama homo sapiens Zhang, S., Zhu, A., Kong, F., Chen, J., Lan, B., He, G., Gao, K., Cheng, L., Yan, C., Chen, L., Liu, X. 3.28 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jty B NA 0 A protein NA solute carrier family 22 member 1 MEMBRANE PROTEIN 03/27/24 hOCT1 in complex with nb5660 in inward facing partially open 2 conformation Homo sapiens; Lama glama lama glama homo sapiens Zhang, S., Zhu, A., Kong, F., Chen, J., Lan, B., He, G., Gao, K., Cheng, L., Yan, C., Chen, L., Liu, X. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8og0 H L 0 P peptide NA alpha-synuclein IMMUNE SYSTEM 03/27/24 Crystal structure of MJF14-6-4-2 Fab fragment in complex with epitope peptide Oryctolagus cuniculus; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Tars, K., Lieknina, I. 1.712 X-RAY DIFFRACTION 0.231 0.195 False True IGHV1 IGKV1 Kappa None None None None None 8r4o B b 0 A protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.725 X-RAY DIFFRACTION 0.244 0.214 True True unknown unknown unknown None None None None None 8r4o D d 0 C protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.725 X-RAY DIFFRACTION 0.244 0.214 True True unknown unknown unknown None None None None None 8r4o F f 0 E protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.725 X-RAY DIFFRACTION 0.244 0.214 True True unknown unknown unknown None None None None None 8r4o H h 0 G protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.725 X-RAY DIFFRACTION 0.244 0.214 True True unknown unknown unknown None None None None None 8r4o J j 0 I protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.725 X-RAY DIFFRACTION 0.244 0.214 True True unknown unknown unknown None None None None None 8r4o L l 0 K protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.725 X-RAY DIFFRACTION 0.244 0.214 True True unknown unknown unknown None None None None None 8r4q B b 0 A protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.838 X-RAY DIFFRACTION 0.244 0.212 True True unknown unknown unknown None None None None None 8r4q D d 0 C protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.838 X-RAY DIFFRACTION 0.244 0.212 True True unknown unknown unknown None None None None None 8r4q F f 0 E protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.838 X-RAY DIFFRACTION 0.244 0.212 True True unknown unknown unknown None None None None None 8r4q H h 0 G protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.838 X-RAY DIFFRACTION 0.244 0.212 True True unknown unknown unknown None None None None None 8r4q J j 0 I protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.838 X-RAY DIFFRACTION 0.244 0.212 True True unknown unknown unknown None None None None None 8r4q L l 0 K protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Salt inducible kinase 3 in complex with inhibitor Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.838 X-RAY DIFFRACTION 0.244 0.212 True True unknown unknown unknown None None None None None 8r4u B b 0 A protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Structure of salt-inducible kinase 3 with inhibitors Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.416 X-RAY DIFFRACTION 0.265 0.228 True True unknown unknown unknown None None None None None 8r4u D d 0 C protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Structure of salt-inducible kinase 3 with inhibitors Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.416 X-RAY DIFFRACTION 0.265 0.228 True True unknown unknown unknown None None None None None 8r4u F f 0 E protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Structure of salt-inducible kinase 3 with inhibitors Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.416 X-RAY DIFFRACTION 0.265 0.228 True True unknown unknown unknown None None None None None 8r4u H h 0 G protein NA serine/threonine-protein kinase sik3 LIGASE 03/27/24 Structure of salt-inducible kinase 3 with inhibitors Homo sapiens homo sapiens homo sapiens Kack, H., Oster, L. 2.416 X-RAY DIFFRACTION 0.265 0.228 True True unknown unknown unknown None None None None None 8t0o H L 0 NA NA NA NA IMMUNE SYSTEM 03/27/24 Fab from mAb RB2AT_87 Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Kreutzer, A.G., Malonis, R.J., Lai, J.R., Nowick, J.S. 2.3 X-RAY DIFFRACTION 0.257 0.215 False True IGHV1 IGKV1 Kappa None None None None None 8tnn H G 0 C protein NA glycoprotein 42 IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gH/gL/gp42 in complex with gp42 antibody A10 Human gammaherpesvirus 4; Macaca fascicularis macaca fascicularis macaca fascicularis human gammaherpesvirus 4 Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 3.36 X-RAY DIFFRACTION 0.281 0.234 False True IGHV6 IGLV3 Lambda None None None None None 8tnn J I 0 F protein NA glycoprotein 42 IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gH/gL/gp42 in complex with gp42 antibody A10 Human gammaherpesvirus 4; Macaca fascicularis macaca fascicularis macaca fascicularis human gammaherpesvirus 4 Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 3.36 X-RAY DIFFRACTION 0.281 0.234 False True IGHV6 IGLV3 Lambda None None None None None 8too B A 0 I protein NA glycoprotein 42 IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12 Epstein-Barr virus; Mus musculus mus musculus mus musculus epstein-barr virus Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 2.6 X-RAY DIFFRACTION 0.275 0.226 False True IGHV1 IGKV10 Kappa None None None None None 8too D C 0 J protein NA glycoprotein 42 IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12 Epstein-Barr virus; Mus musculus mus musculus mus musculus epstein-barr virus Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 2.6 X-RAY DIFFRACTION 0.275 0.226 False True IGHV1 IGKV10 Kappa None None None None None 8too H E 0 L protein NA glycoprotein 42 IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12 Epstein-Barr virus; Mus musculus mus musculus mus musculus epstein-barr virus Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 2.6 X-RAY DIFFRACTION 0.275 0.226 False True IGHV1 IGKV10 Kappa None None None None None 8too G F 0 K protein NA glycoprotein 42 IMMUNE SYSTEM 03/27/24 Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12 Epstein-Barr virus; Mus musculus mus musculus mus musculus epstein-barr virus Bu, W., Kumar, A., Board, N., Kim, J., Dowdell, K., Zhang, S., Lei, Y., Hostal, A., Krogmann, T., Wang, Y., Pittaluga, S., Marcotrigiano, J., Cohen, J.I. 2.6 X-RAY DIFFRACTION 0.275 0.226 False True IGHV1 IGKV10 Kappa None None None None None 8u1c H L 0 A protein NA neuraminidase HYDROLASE 03/27/24 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface Homo sapiens; Influenza B virus (B/Iowa/06/2017) homo sapiens homo sapiens influenza b virus (b/iowa/06/2017) Ferguson, J.A., Oeverdieck, S., Ward, A.B. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8u1q H L 0 A protein NA neuraminidase HYDROLASE 03/27/24 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface Homo sapiens; Influenza B virus (B/Iowa/06/2017) homo sapiens homo sapiens influenza b virus (b/iowa/06/2017) Ferguson, J.A., Oeverdieck, S., Ward, A.B. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8u1s J K 0 D protein NA neuraminidase HYDROLASE 03/27/24 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface Homo sapiens; Influenza B virus (B/Iowa/06/2017) homo sapiens homo sapiens influenza b virus (b/iowa/06/2017) Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8u1s G I 0 C protein NA neuraminidase HYDROLASE 03/27/24 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface Homo sapiens; Influenza B virus (B/Iowa/06/2017) homo sapiens homo sapiens influenza b virus (b/iowa/06/2017) Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8u1s E F 0 B protein NA neuraminidase HYDROLASE 03/27/24 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface Homo sapiens; Influenza B virus (B/Iowa/06/2017) homo sapiens homo sapiens influenza b virus (b/iowa/06/2017) Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8u1s H L 0 A protein NA neuraminidase HYDROLASE 03/27/24 A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface Homo sapiens; Influenza B virus (B/Iowa/06/2017) homo sapiens homo sapiens influenza b virus (b/iowa/06/2017) Ferguson, J.A., Raghavan, S.S.R., Ward, A.B. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8vye B C 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vye A D 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8vye H L 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8vye F G 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vye I J 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8vye M N 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8vye P Q 0 O protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vye R S 0 O protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8vye T U 0 O protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.7 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8vyf B C 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S NTD (C.37 Lambda variant) plus S2L20 and S2X303 Fabs, local refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8vyf H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S NTD (C.37 Lambda variant) plus S2L20 and S2X303 Fabs, local refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8vyg A B 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/27/24 SARS-CoV-2 S RBD (C.37 Lambda variant) plus S309 Fab, local refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8w0v H L 0 C protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 03/27/24 Crystal structure of broadly neutralizing antibody hcab55 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepacivirus hominis; Homo sapiens homo sapiens homo sapiens hepacivirus hominis Flyak, A.I., Wilcox, X.E. 2.59 X-RAY DIFFRACTION 0.257 0.202 False True IGHV1 IGKV3 Kappa None None None None None 8w0w H L 0 C protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 03/27/24 Crystal structure of broadly neutralizing antibody hcab64 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepacivirus hominis; Homo sapiens homo sapiens homo sapiens hepacivirus hominis Flyak, A.I., Wilcox, X.E. 2.13 X-RAY DIFFRACTION 0.224 0.195 False True IGHV1 IGKV3 Kappa None None None None None 8w0x H L 0 C protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 03/27/24 Crystal structure of broadly neutralizing antibody hcab40 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepacivirus hominis; Homo sapiens homo sapiens homo sapiens hepacivirus hominis Flyak, A.I., Wilcox, X.E. 3.12 X-RAY DIFFRACTION 0.271 0.227 False True IGHV4 IGKV1 Kappa None None None None None 8w0y A B 0 D protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 03/27/24 Crystal structure of broadly neutralizing antibody hcab17 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepacivirus hominis; Homo sapiens homo sapiens homo sapiens hepacivirus hominis Flyak, A.I., Wilcox, X.E. 3.31 X-RAY DIFFRACTION 0.253 0.209 False True IGHV4 IGKV1 Kappa None None None None None 8w0y H L 0 C protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 03/27/24 Crystal structure of broadly neutralizing antibody hcab17 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Hepacivirus hominis; Homo sapiens homo sapiens homo sapiens hepacivirus hominis Flyak, A.I., Wilcox, X.E. 3.31 X-RAY DIFFRACTION 0.253 0.209 False True IGHV4 IGKV1 Kappa None None None None None 8g0i D NA 0 A protein NA green fluorescent protein IMMUNE SYSTEM 03/20/24 High Affinity nanobodies against GFP Aequorea victoria; Lama glama lama glama aequorea victoria Ketaren, N.E., Rout, M.P., Almo, S. 2.2 X-RAY DIFFRACTION 0.241 0.181 False True IGHV1 NA NA None None None None None 8gkj A B 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal Structure of the Murine MUC16 Specific Antibody AR9.6 Mus musculus mus musculus mus musculus Brooks, C.L., Aguilar, E.N. 1.9 X-RAY DIFFRACTION 0.219 0.182 False True IGHV5 IGKV3 Kappa None None None None None 8gkj C D 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal Structure of the Murine MUC16 Specific Antibody AR9.6 Mus musculus mus musculus mus musculus Brooks, C.L., Aguilar, E.N. 1.9 X-RAY DIFFRACTION 0.219 0.182 False True IGHV5 IGKV3 Kappa None None None None None 8gkk H L 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Crystal Structure of the Humanized MUC16 Specific Antibody huAR9.6 Homo sapiens homo sapiens homo sapiens Brooks, C.L., Murray, B. 1.75 X-RAY DIFFRACTION 0.192 0.167 False True IGHV3 IGKV3 Kappa None None None None None 8gkl H L 0 E protein NA mucin-16 IMMUNE SYSTEM 03/20/24 Crystal Structure of the Humanized MUC16 Specific Antibody huAR9.6 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Brooks, C.L., Aguilar, E.N. 2.6 X-RAY DIFFRACTION 0.269 0.215 False True IGHV5 IGKV3 Kappa None None None None None 8iow H L 0 I protein NA interleukin-6 receptor subunit alpha IMMUNE SYSTEM 01/08/09 Cryo-EM structure of the sarilumab Fab/IL-6R complex Homo sapiens homo sapiens homo sapiens homo sapiens She, J., Chen, L., Wang, M.X. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8irw A NA 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Structure of nanobody Nb9 against parathion Camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 1.55 X-RAY DIFFRACTION 0.225 0.193 False True IGHV1 NA NA None None None None None 8irw B NA 0 NA NA NA NA IMMUNE SYSTEM 03/20/24 Structure of nanobody Nb9 against parathion Camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 1.55 X-RAY DIFFRACTION 0.225 0.193 False True IGHV1 NA NA None None None None None 8jxt E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/20/24 Histamine-bound H4R/Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Xia, R. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jxv E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/20/24 Clozapine-bound H4R/Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Xia, R. 3.21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jxw E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/20/24 VUF6884-bound H4R/Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Xia, R. 3.01 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jxx E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/20/24 Clobenpropit-bound H4R/Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Xia, R. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8sxp H L 0 C protein NA long neurotoxin 2 TOXIN/IMMUNE SYSTEM 03/20/24 Crystal structure of long neurotoxin from the venom of the king cobra (3FTx-L15) in complex with Fab of broadly neutralizing antibody 95Mat5 Homo sapiens; Ophiophagus hannah homo sapiens homo sapiens ophiophagus hannah Nguyen, T.K.Y. 2.9 X-RAY DIFFRACTION 0.320 0.261 False True IGHV1 IGKV1 Kappa None None None None None 8tbq H L 0 P protein NA v-type immunoglobulin domain-containing suppressor of t-cell activation PROTEIN BINDING,IMMUNE SYSTEM 03/20/24 The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody Homo sapiens homo sapiens homo sapiens homo sapiens van der Horst, E.H., Mukherjee, A., Thisted, T. 2.593 X-RAY DIFFRACTION 0.291 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8tbq A B 0 Q protein NA v-type immunoglobulin domain-containing suppressor of t-cell activation PROTEIN BINDING,IMMUNE SYSTEM 03/20/24 The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody Homo sapiens homo sapiens homo sapiens homo sapiens van der Horst, E.H., Mukherjee, A., Thisted, T. 2.593 X-RAY DIFFRACTION 0.291 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8wu1 H L 0 C | R protein | protein NA | NA beta-arrestin-1 | cannabinoid receptor 1,vasopressin v2 receptor MEMBRANE PROTEIN 03/20/24 Cryo-EM structure of CB1-beta-arrestin1 complex Bos taurus; Homo sapiens homo sapiens homo sapiens bos taurus | homo sapiens Liao, Y., Zhang, H., Shen, Q., Cai, C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xzf S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/20/24 Cryo-EM structure of the WN561-bound human APLNR-Gi complex Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Wang, W., Ji, S., Zhang, Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xzh S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/20/24 Cryo-EM structure of the MM07-bound human APLNR-Gi complex Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Wang, W., Ji, S., Zhang, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xzi S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Wang, W., Ji, S., Zhang, Y. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xzj S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/20/24 Cryo-EM structure of the WN353-bound human APLNR-Gi complex Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Wang, W., Ji, S., Zhang, Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gdr C D 0 F protein NA spike glycoprotein VIRAL PROTEIN 03/13/24 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E.A. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 8gdr H J 0 E | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 03/13/24 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E.A. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 8oz3 A B 0 C protein NA tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 03/13/24 Crystal structure of scFv ATOR 1017 bound to human 4-1BB Homo sapiens homo sapiens homo sapiens homo sapiens Hakansson, M., Von Schantz, L., Rose, N. 3.1 X-RAY DIFFRACTION 0.271 0.205 True True IGHV3 IGKV1 Kappa None None None None None 8oz3 H L 0 D protein NA tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 03/13/24 Crystal structure of scFv ATOR 1017 bound to human 4-1BB Homo sapiens homo sapiens homo sapiens homo sapiens Hakansson, M., Von Schantz, L., Rose, N. 3.1 X-RAY DIFFRACTION 0.271 0.205 True True IGHV3 IGKV1 Kappa None None None None None 8evd A NA 0 C protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH101 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Beauchemin, K.S., Madden, D.R. 2 X-RAY DIFFRACTION 0.206 0.184 False True IGHV1 NA NA None None None None None 8evd B NA 0 D protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH101 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Beauchemin, K.S., Madden, D.R. 2 X-RAY DIFFRACTION 0.206 0.184 False True IGHV1 NA NA None None None None None 8evd E NA 0 G protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH101 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Beauchemin, K.S., Madden, D.R. 2 X-RAY DIFFRACTION 0.206 0.184 False True IGHV1 NA NA None None None None None 8evd F NA 0 H protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH101 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Beauchemin, K.S., Madden, D.R. 2 X-RAY DIFFRACTION 0.206 0.184 False True IGHV1 NA NA None None None None None 8evd I NA 0 K protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH101 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Beauchemin, K.S., Madden, D.R. 2 X-RAY DIFFRACTION 0.206 0.184 False True IGHV1 NA NA None None None None None 8evd J NA 0 L protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH101 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Beauchemin, K.S., Madden, D.R. 2 X-RAY DIFFRACTION 0.206 0.184 False True IGHV1 NA NA None None None None None 8f6u B NA 0 D protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Mishra, A.K., Madden, D.R. 1.7 X-RAY DIFFRACTION 0.199 0.176 False True IGHV1 NA NA None None None None None 8f6u A NA 0 C protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Taher, N.M., Mishra, A.K., Madden, D.R. 1.7 X-RAY DIFFRACTION 0.199 0.176 False True IGHV1 NA NA None None None None None 8f6v A NA 0 C protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH108 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.3 X-RAY DIFFRACTION 0.210 0.181 False True IGHV1 NA NA None None None None None 8f6v B NA 0 D protein NA cftr inhibitory factor IMMUNE SYSTEM 03/13/24 Crystal Structure of Nanobody VHH108 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.3 X-RAY DIFFRACTION 0.210 0.181 False True IGHV1 NA NA None None None None None 8gdo H L 0 NA NA NA NA IMMUNE SYSTEM 03/13/24 Crystal structure of DH1010 Fab Homo sapiens homo sapiens homo sapiens Lindenberger, J., Acharya, P. 1.95 X-RAY DIFFRACTION 0.247 0.203 False True IGHV1 IGKV2 Kappa None None None None None 8jyq A B 0 C peptide NA h2casmab-1 epitope peptide IMMUNE SYSTEM 03/13/24 Crystal structure of cancer-specific anti-HER2 antibody H2Mab-214 in complex with epitope peptide Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 1.75 X-RAY DIFFRACTION 0.233 0.196 False True IGHV8 IGKV3 Kappa None None None None None 8jyq D E 0 F peptide NA h2casmab-1 epitope peptide IMMUNE SYSTEM 03/13/24 Crystal structure of cancer-specific anti-HER2 antibody H2Mab-214 in complex with epitope peptide Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 1.75 X-RAY DIFFRACTION 0.233 0.196 False True IGHV8 IGKV3 Kappa None None None None None 8jyr H L 0 A protein NA receptor tyrosine-protein kinase erbb-2 IMMUNE SYSTEM 03/13/24 Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Arimori, T., Takagi, J. 1.69 X-RAY DIFFRACTION 0.209 0.173 False True IGHV1 IGKV3 Kappa None None None None None 8qf3 E NA 0 NA NA NA NA IMMUNE SYSTEM 03/13/24 1.25-A structure of anti-Arc nanobody H11 Vicugna pacos vicugna pacos Godoy Munoz, J.M., Kursula, P. 1.25 X-RAY DIFFRACTION 0.232 0.185 False True IGHV1 NA NA None None None None None 8qf3 A NA 0 NA NA NA NA IMMUNE SYSTEM 03/13/24 1.25-A structure of anti-Arc nanobody H11 Vicugna pacos vicugna pacos Godoy Munoz, J.M., Kursula, P. 1.25 X-RAY DIFFRACTION 0.232 0.185 False True IGHV1 NA NA None None None None None 8qf4 E NA 0 A protein NA activity-regulated cytoskeleton-associated protein IMMUNE SYSTEM 03/13/24 Complex between N-lobe of Arc and nanobody H11 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Godoy Munoz, J.M., Kursula, P. 1.02 X-RAY DIFFRACTION 0.160 0.129 False True IGHV1 NA NA None None None None None 8qf5 G NA 0 H protein NA activity-regulated cytoskeleton-associated protein IMMUNE SYSTEM 03/13/24 Complex between N-lobe of Arc and nanobody E5 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Godoy Munoz, J.M., Kursula, P. 1.5 X-RAY DIFFRACTION 0.193 0.145 False True IGHV1 NA NA None None None None None 8qf5 A NA 0 B protein NA activity-regulated cytoskeleton-associated protein IMMUNE SYSTEM 03/13/24 Complex between N-lobe of Arc and nanobody E5 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Godoy Munoz, J.M., Kursula, P. 1.5 X-RAY DIFFRACTION 0.193 0.145 False True IGHV1 NA NA None None None None None 8r1c H L 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/13/24 SD1-2 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8r1c D E 0 B protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/13/24 SD1-2 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8r1c F G 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/13/24 SD1-2 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8r1d F G 0 B protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/13/24 SD1-3 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Enterobacteria phage T4; Homo sapiens homo sapiens homo sapiens homo sapiens, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.37 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8r1d D E 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/13/24 SD1-3 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Enterobacteria phage T4; Homo sapiens homo sapiens homo sapiens homo sapiens, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.37 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8r1d H L 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/13/24 SD1-3 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein Enterobacteria phage T4; Homo sapiens homo sapiens homo sapiens homo sapiens, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.37 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8sdf H L 0 Z protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.4 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 1.79 X-RAY DIFFRACTION 0.218 0.186 False True IGHV1 IGLV1 Lambda None None None None None 8sdf B C 0 A protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.4 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 1.79 X-RAY DIFFRACTION 0.218 0.186 False True IGHV1 IGLV1 Lambda None None None None None 8sdg G I 0 C protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.43 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.71 X-RAY DIFFRACTION 0.308 0.255 False True IGHV3 IGKV1 Kappa None None None None None 8sdg A B 0 D protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.43 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.71 X-RAY DIFFRACTION 0.308 0.255 False True IGHV3 IGKV1 Kappa None None None None None 8siq H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibodies CC25.36 and CV38-142 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.287 0.247 False True IGHV3 IGLV1 Lambda None None None None None 8siq M N 0 A protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibodies CC25.36 and CV38-142 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.287 0.247 False True IGHV5 IGKV1 Kappa None None None None None 8sir H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC25.54 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 3.3 X-RAY DIFFRACTION 0.236 0.208 False True IGHV4 IGKV1 Kappa None None None None None 8sis H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 3.08 X-RAY DIFFRACTION 0.303 0.256 False True IGHV1 IGKV3 Kappa None None None None None 8sit H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.24 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.91 X-RAY DIFFRACTION 0.309 0.261 False True IGHV3 IGLV3 Lambda None None None None None 8sit M N 0 B protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.24 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.91 X-RAY DIFFRACTION 0.309 0.261 False True IGHV3 IGLV3 Lambda None None None None None 8sit O P 0 C protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.24 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.91 X-RAY DIFFRACTION 0.309 0.261 False True IGHV3 IGLV3 Lambda None None None None None 8sit Q S 0 D protein NA spike protein s1 IMMUNE SYSTEM 03/13/24 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.24 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.91 X-RAY DIFFRACTION 0.309 0.261 False True IGHV3 IGLV3 Lambda None None None None None 8u4q H L 0 R protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 03/13/24 Structure of REGN7663 Fab-bound CXCR4/Gi complex Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4r H L 0 R protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 03/13/24 Structure of REGN7663-Fab bound CXCR4 Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4s H L 0 R protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 03/13/24 Structure of trimeric CXCR4 in complex with REGN7663 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4s B A 0 C protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 03/13/24 Structure of trimeric CXCR4 in complex with REGN7663 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4s F E 0 G protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 03/13/24 Structure of trimeric CXCR4 in complex with REGN7663 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4t H L 0 R protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 01/08/09 Structure of tetrameric CXCR4 in complex with REGN7663 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4t G F 0 I protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 01/08/09 Structure of tetrameric CXCR4 in complex with REGN7663 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4t P O 0 Q protein NA c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 01/08/09 Structure of tetrameric CXCR4 in complex with REGN7663 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8u4t Z Y 0 A protein NA unknown SIGNALING PROTEIN/IMMUNE SYSTEM 01/08/09 Structure of tetrameric CXCR4 in complex with REGN7663 Fab Homo sapiens homo sapiens homo sapiens Saotome, K., McGoldrick, L.L., Franklin, M.C. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8iy9 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/06/24 Structure of Niacin-GPR109A-G protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Sarma, P., Chami, M., Banerjee, R., Shukla, A.K. 3.37 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iyh H h 0 B | A protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/06/24 Structure of MK6892-GPR109A-G-protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Sarma, P., Chami, M., Banerjee, R., Shukla, A.K. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iyw H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/06/24 Structure of GSK256073-GPR109A-G-protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Sarma, P., Chami, M., Banerjee, R., Shukla, A.K. 3.45 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jer H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/06/24 Structure of Acipimox-GPR109A-G protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Sarma, P., Chami, M., Banerjee, R., Shukla, A.K. 3.45 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jhn H h 0 A | B protein | protein NA | NA g protein subunit alpha o1,guanine nucleotide-bindingprotein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/06/24 Structure of MMF-GPR109A-G protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Sarma, P., Chami, M., Banerjee, R., Shukla, A.K. 3.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8pok E NA 0 B | C protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/06/24 Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Schnelle, K., Koeck, Z., Persechino, M., Umbach, S., Schihada, H., Januliene, D., Parey, K., Pockes, S., Kolb, P., Doetsch, V., Moeller, A., Hilger, D., Bernhard, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8pyr D NA 0 A protein NA cyclin-dependent kinase 7 TRANSCRIPTION 03/06/24 Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex Homo sapiens; Lama glama lama glama homo sapiens Anand, K., Duster, R., Geyer, M. 2.15 X-RAY DIFFRACTION 0.242 0.220 False True IGHV3 NA NA None None None None None 8pyr H NA 0 E protein NA cyclin-dependent kinase 7 TRANSCRIPTION 03/06/24 Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex Homo sapiens; Lama glama lama glama homo sapiens Anand, K., Duster, R., Geyer, M. 2.15 X-RAY DIFFRACTION 0.242 0.220 False True IGHV3 NA NA None None None None None 8smk B C 0 A protein NA protein-arginine deiminase type-4 IMMUNE SYSTEM 03/06/24 hPAD4 bound to Activating Fab hA362 Homo sapiens homo sapiens homo sapiens homo sapiens Maker, A., Verba, K.A. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8smk E F 0 D protein NA protein-arginine deiminase type-4 IMMUNE SYSTEM 03/06/24 hPAD4 bound to Activating Fab hA362 Homo sapiens homo sapiens homo sapiens homo sapiens Maker, A., Verba, K.A. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8sml C B 0 A protein NA protein-arginine deiminase type-4 HYDROLASE/IMMUNE SYSTEM 03/06/24 hPAD4 bound to inhibitory Fab hI365 Homo sapiens homo sapiens homo sapiens homo sapiens Maker, A., Verba, K.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8sml F E 0 D protein NA protein-arginine deiminase type-4 HYDROLASE/IMMUNE SYSTEM 03/06/24 hPAD4 bound to inhibitory Fab hI365 Homo sapiens homo sapiens homo sapiens homo sapiens Maker, A., Verba, K.A. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8w9h H L 0 NA NA NA NA IMMUNE SYSTEM 03/06/24 Crystal structure of anti-human CLEC12A antibody 50C1 Mus musculus mus musculus mus musculus Mori, S., Nagae, M., Yamasaki, S. 2 X-RAY DIFFRACTION 0.233 0.189 False False IGHV1 IGKV3 Kappa None None None None None 8w9h B A 0 NA NA NA NA IMMUNE SYSTEM 03/06/24 Crystal structure of anti-human CLEC12A antibody 50C1 Mus musculus mus musculus mus musculus Mori, S., Nagae, M., Yamasaki, S. 2 X-RAY DIFFRACTION 0.233 0.189 False False IGHV1 IGKV3 Kappa None None None None None 8w9j H L 0 C protein NA c-type lectin domain family 12 member a IMMUNE SYSTEM 03/06/24 Crystal structure of human CLEC12A ectodomain complexed with 50C1 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Mori, S., Nagae, M., Yamasaki, S. 3.5 X-RAY DIFFRACTION 0.291 0.254 False False IGHV1 IGKV3 Kappa None None None None None 8w9j B A 0 D protein NA c-type lectin domain family 12 member a IMMUNE SYSTEM 03/06/24 Crystal structure of human CLEC12A ectodomain complexed with 50C1 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Mori, S., Nagae, M., Yamasaki, S. 3.5 X-RAY DIFFRACTION 0.291 0.254 False False IGHV1 IGKV3 Kappa None None None None None 8wa3 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,o-antigen polymerase STRUCTURAL PROTEIN 03/06/24 Cryo-EM structure of peptide free and Gs-coupled GIPR Bos taurus; Homo sapiens; Leptolinea tardivitalis; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus, leptolinea tardivitalis Cong, Z.T., Zhao, F.H., Li, Y., Luo, G., Zhou, Q.T., Yang, D.H., Wang, M.W. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8wg7 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/06/24 Cryo-EM structures of peptide free and Gs-coupled GLP-1R Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | rattus norvegicus Cong, Z.T., Zhao, F.H., Li, Y., Luo, G., Zhou, Q.T., Yang, D.H., Wang, M.W. 2.54 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8wg8 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/06/24 Cryo-EM structures of peptide free and Gs-coupled GCGR Bos taurus; Homo sapiens; Rattus norvegicus; Spodoptera frugiperda; synthetic construct synthetic construct homo sapiens | rattus norvegicus Cong, Z.T., Zhao, F.H., Li, Y., Luo, G., Zhou, Q.T., Yang, D.H., Wang, M.W. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8x79 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,gnas complex locus,gnas complex locus | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/06/24 MRE-269 bound Prostacyclin Receptor G protein complex Homo sapiens homo sapiens homo sapiens | homo sapiens Wang, J.J., Jin, S., Zhang, H., Xu, Y., Hu, W., Jiang, Y., Chen, C., Wang, D.W., Xu, H.E., Wu, C. 2.41 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8x7a N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,gnas complex locus | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/06/24 Treprostinil bound Prostacyclin Receptor G protein complex Homo sapiens homo sapiens homo sapiens | homo sapiens Wang, J.J., Jin, S., Zhang, H., Xu, Y., Hu, W., Jiang, Y., Chen, C., Wang, D.W., Xu, H.E., Wu, C. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xe9 A B 0 C protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 03/06/24 XBB.1.5 RBD in complex with BD55-1205 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Feng, L.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8cma H L 0 E protein NA spike protein s1 VIRAL PROTEIN 02/28/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-35 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.29 X-RAY DIFFRACTION 0.268 0.231 False True IGHV3 IGKV3 Kappa None None None None None 8gag S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/28/24 Cannabinoid receptor 1-Gi complex with novel ligand Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Tummino, T.A., Iliopoulos-Tsoutsouvas, C., Braz, J.M., O'Brien, E.S., Krishna Kumar, K., Makriyannis, M., Basbaum, A.I., Shoichet, B.K. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gat M N 0 A protein NA vasodilator-stimulated phosphoprotein, neuraminidasechimera VIRAL PROTEIN/IMMUNE SYSTEM 02/28/24 Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v), based on consensus cryo-EM map with only Fab 1G01 resolved Homo sapiens; Influenza A virus (A/Indiana/10/2011(H3N2)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/indiana/10/2011(h3n2)) Tsybovsky, Y., Lederhofer, J., Kwong, P.D., Kanekiyo, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gau H L 0 A protein NA vasodilator-stimulated phosphoprotein, neuraminidasechimera VIRAL PROTEIN/IMMUNE SYSTEM 02/28/24 Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v) Homo sapiens; Influenza A virus (A/Indiana/10/2011(H3N2)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/indiana/10/2011(h3n2)) Tsybovsky, Y., Lederhofer, J., Kwong, P.D., Kanekiyo, M. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8gau M N 0 A protein NA vasodilator-stimulated phosphoprotein, neuraminidasechimera VIRAL PROTEIN/IMMUNE SYSTEM 02/28/24 Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v) Homo sapiens; Influenza A virus (A/Indiana/10/2011(H3N2)) homo sapiens homo sapiens homo sapiens, influenza a virus(a/indiana/10/2011(h3n2)) Tsybovsky, Y., Lederhofer, J., Kwong, P.D., Kanekiyo, M. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gav H L 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 02/28/24 Structure of human NDS.3 Fab in complex with influenza virus neuraminidase from A/Darwin/09/2021 (H3N2) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Tsybovsky, Y., Lederhofer, J., Kwong, P.D., Kanekiyo, M. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8idi A NA 0 D protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-T71 with MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 1.901 X-RAY DIFFRACTION 0.207 0.173 False True unknown unknown unknown None None None None None 8idi C NA 0 B protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-T71 with MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 1.901 X-RAY DIFFRACTION 0.207 0.173 False True unknown unknown unknown None None None None None 8idm B NA 0 D protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-227 with nanobody VHH-T71 and MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 3.59 X-RAY DIFFRACTION 0.273 0.253 False True unknown unknown unknown None None None None None 8idm A NA 0 D protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-227 with nanobody VHH-T71 and MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 3.59 X-RAY DIFFRACTION 0.273 0.253 False True unknown unknown unknown None None None None None 8ido C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-T148 with MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 2.5 X-RAY DIFFRACTION 0.262 0.220 False True unknown unknown unknown None None None None None 8ido D NA 0 B protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-T148 with MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 2.5 X-RAY DIFFRACTION 0.262 0.220 False True unknown unknown unknown None None None None None 8iee D NA 0 A protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-31 with MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 3.21 X-RAY DIFFRACTION 0.252 0.243 False True IGHV1 NA NA None None None None None 8iee C NA 0 B protein NA spike protein s1 VIRAL PROTEIN 02/28/24 Crystal structure of nanobody VHH-31 with MERS-CoV RBD Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 3.21 X-RAY DIFFRACTION 0.252 0.243 False True IGHV1 NA NA None None None None None 8ifn A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/28/24 MERS-CoV spike trimer in complex with nanobody VHH-T148 Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 2.81 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ifn D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/28/24 MERS-CoV spike trimer in complex with nanobody VHH-T148 Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 2.81 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ifn F NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 02/28/24 MERS-CoV spike trimer in complex with nanobody VHH-T148 Camelus dromedarius; Middle East respiratory syndrome-related coronavirus camelus dromedarius middle east respiratory syndrome-relatedcoronavirus Wang, X., Tian, L. 2.81 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8jbf E e 0 C | D protein | protein NA | NA guanine nucleotide-binding protein gq subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/28/24 Senktide bound to active human neurokinin 3 receptor in complex with Gq Bos taurus; Homo sapiens; Mus musculoides; Rattus norvegicus mus musculoides homo sapiens | rattus norvegicus Sun, W.J., Yang, F., Zhang, H.H., Yuan, Q.N., Yin, W.C., Shi, P., Eric, X., Tian, C.L. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jel C D 0 J protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.45 X-RAY DIFFRACTION 0.249 0.192 False True IGHV3 IGKV3 Kappa None None None None None 8jel A B 0 E protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.45 X-RAY DIFFRACTION 0.249 0.192 False True IGHV3 IGKV3 Kappa None None None None None 8jel F G 0 H protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.45 X-RAY DIFFRACTION 0.249 0.192 False True IGHV3 IGKV3 Kappa None None None None None 8jel I K 0 L protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.45 X-RAY DIFFRACTION 0.249 0.192 False True IGHV3 IGKV3 Kappa None None None None None 8jen A B 0 I protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.71 X-RAY DIFFRACTION 0.289 0.218 False True IGHV3 IGKV3 Kappa None None None None None 8jen C D 0 J protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.71 X-RAY DIFFRACTION 0.289 0.218 False True IGHV3 IGKV3 Kappa None None None None None 8jen E F 0 M protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.71 X-RAY DIFFRACTION 0.289 0.218 False True IGHV3 IGKV3 Kappa None None None None None 8jen G H 0 P protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.71 X-RAY DIFFRACTION 0.289 0.218 False True IGHV3 IGKV3 Kappa None None None None None 8jeo B C 0 A protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Tiragolumab Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.06 X-RAY DIFFRACTION 0.206 0.172 False True IGHV6 IGKV4 Kappa None None None None None 8jeo E F 0 D protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 02/28/24 Crystal structure of TIGIT in complexed with Tiragolumab Homo sapiens homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 2.06 X-RAY DIFFRACTION 0.206 0.172 False True IGHV6 IGKV4 Kappa None None None None None 8jep A B 0 NA NA NA NA IMMUNE SYSTEM 02/28/24 Crystal structure of Ociperlimab Homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 1.7 X-RAY DIFFRACTION 0.210 0.184 False True IGHV3 IGKV3 Kappa None None None None None 8jep C D 0 NA NA NA NA IMMUNE SYSTEM 02/28/24 Crystal structure of Ociperlimab Homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 1.7 X-RAY DIFFRACTION 0.210 0.184 False True IGHV3 IGKV3 Kappa None None None None None 8jeq A B 0 NA NA NA NA IMMUNE SYSTEM 02/28/24 Crystal structure of Tiragolumab Homo sapiens homo sapiens homo sapiens Sun, J., Zhang, X.X., Song, J. 1.96 X-RAY DIFFRACTION 0.222 0.186 False True IGHV6 IGKV4 Kappa None None None None None 8jt6 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/28/24 5-HT1A-Gi in complex with compound (R)-IHCH-7179 Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Chen, Z., Xu, P., Huang, S., Xu, H.E., Wang, S. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ozb A NA 0 F protein NA nucleoporin nup35 TRANSPORT PROTEIN 02/28/24 Crystal structure of Nup35-Nb complex Homo sapiens; Lama glama lama glama homo sapiens Srinivasan, V. 2.09 X-RAY DIFFRACTION 0.267 0.242 False True IGHV1 NA NA None None None None None 8ozb C NA 0 E protein NA nucleoporin nup35 TRANSPORT PROTEIN 02/28/24 Crystal structure of Nup35-Nb complex Homo sapiens; Lama glama lama glama homo sapiens Srinivasan, V. 2.09 X-RAY DIFFRACTION 0.267 0.242 False True IGHV1 NA NA None None None None None 8t60 H L 0 NA NA NA NA TRANSPORT PROTEIN 01/08/09 CryoEM structure of an inward-facing MelBSt at a Na(+)-bound and sugar low-affinity conformation Salmonella enterica subsp. enterica serovar Typhimurium; synthetic construct synthetic construct synthetic construct Guan, L. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8t60 B NA 0 A protein NA melibiose permease TRANSPORT PROTEIN 01/08/09 CryoEM structure of an inward-facing MelBSt at a Na(+)-bound and sugar low-affinity conformation Salmonella enterica subsp. enterica serovar Typhimurium; synthetic construct synthetic construct salmonella enterica subsp. enterica serovartyphimurium Guan, L. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8wrz H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | vasopressin v2 receptor MEMBRANE PROTEIN 02/28/24 Cry-EM structure of cannabinoid receptor-arrestin 2 complex Escherichia coli; Homo sapiens; Phage display vector pTDisp phage display vector ptdisp phage display vector ptdisp homo sapiens | homo sapiens Wang, Y.X., Wang, T., Wu, L.J., Hua, T., Liu, Z.J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8xej H L 0 B | X protein | protein NA | NA isoform 2 of basigin | xk-related protein 8 LIPID TRANSPORT 02/28/24 Cryo-EM structure of human XKR8-basigin complex in lipid nanodisc Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens | homo sapiens Sakuragi, T.S., Kanai, R.K., Kikkawa, M.K., Toyoshima, C.T., Nagata, S.N. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8xjk E e 0 A | B protein | protein NA | NA engineered minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Li, X., Liu, G., Gong, W. 2.63 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xjl E e 0 A | B protein | protein NA | NA engineered minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/28/24 PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Li, X., Liu, G., Gong, W. 2.77 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xjm E e 0 A | B protein | protein NA | NA engineered minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/28/24 Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Li, X., Liu, G., Gong, W. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xjn E e 0 A | B protein | protein NA | NA engineered minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Li, X., Liu, G., Gong, W. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xjo E e 0 A | B protein | protein NA | NA engineered minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/28/24 U46619 bound Thromboxane A2 receptor-Gq Protein Complex Homo sapiens; synthetic construct synthetic construct synthetic construct | homo sapiens Zhang, X., Li, X., Liu, G., Gong, W. 3.11 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8cds A NA 0 NA NA NA NA IMMUNE SYSTEM 02/21/24 Crystal structure of the xhNup93-Nb4i VHH antibody Vicugna pacos vicugna pacos Guttler, T., Colom, M.S., Gorlich, D. 1.53 X-RAY DIFFRACTION 0.176 0.133 False True IGHV1 NA NA None None None None None 8cdt A NA 0 NA NA NA NA IMMUNE SYSTEM 02/21/24 Crystal structure of the xNup93-Nb2t VHH antibody Vicugna pacos vicugna pacos Guttler, T., Colom, M.S., Gorlich, D. 1.41 X-RAY DIFFRACTION 0.188 0.158 False True IGHV3 NA NA None None None None None 8chs D NA 0 A protein NA bifunctional heparan sulfate n-deacetylase/n-sulfotransferase 1 CARBOHYDRATE 02/21/24 Human heparan sulfate N-deacetylase-N-sulfotransferase 1 in complex with calcium, 3'-phosphoadenosine-5'-phosphosulfate and nanobody nAb13 (composite map and model). Homo sapiens; Lama glama lama glama homo sapiens Mycroft-West, C.J., Wu, L. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cii H L 0 E protein NA spike protein s2' VIRUS 02/21/24 Delta-RBD complex with BA.2-07 fab, SARS1-34 fab and C1 nanobody Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8cii A B 0 E protein NA spike protein s2' VIRUS 02/21/24 Delta-RBD complex with BA.2-07 fab, SARS1-34 fab and C1 nanobody Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8cii C NA 0 E protein NA spike protein s2' VIRUS 02/21/24 Delta-RBD complex with BA.2-07 fab, SARS1-34 fab and C1 nanobody Homo sapiens; Lama glama lama glama homo sapiens Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cin E F 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/21/24 BA.4/5-5 FAB IN COMPLEX WITH SARS-COV-2 BA.4 SPIKE GLYCOPROTEIN Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8cin H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/21/24 BA.4/5-5 FAB IN COMPLEX WITH SARS-COV-2 BA.4 SPIKE GLYCOPROTEIN Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8cin J K 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/21/24 BA.4/5-5 FAB IN COMPLEX WITH SARS-COV-2 BA.4 SPIKE GLYCOPROTEIN Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8ekd E F 0 G protein NA spike protein s2' IMMUNE SYSTEM 02/21/24 Cryo-EM map of SARS-CoV-2 Omicron BA.2 spike in complex with LLNL-199 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Binshtein, E., Crowe, J.E. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 8g5a H L 0 A protein NA hemagglutinin VIRAL PROTEIN 02/21/24 X-31 hemagglutinin in complex with FL-1061 Fab Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Windsor, I.W., Thornlow, D., Schmidt, A.G. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV16 Kappa None None None None None 8g5a I M 0 B protein NA hemagglutinin VIRAL PROTEIN 02/21/24 X-31 hemagglutinin in complex with FL-1061 Fab Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Windsor, I.W., Thornlow, D., Schmidt, A.G. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV16 Kappa None None None None None 8g5a J N 0 C protein NA hemagglutinin VIRAL PROTEIN 02/21/24 X-31 hemagglutinin in complex with FL-1061 Fab Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Windsor, I.W., Thornlow, D., Schmidt, A.G. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV16 Kappa None None None None None 8g5b H L 0 A protein NA hemagglutinin VIRAL PROTEIN 02/21/24 Influenza A H3N2 X-31 Hemagglutinin in complex with FL-1061 Homo sapiens; Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Windsor, I.W., Thornlow, D., Schmidt, A.G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8g5b I M 0 A protein NA hemagglutinin VIRAL PROTEIN 02/21/24 Influenza A H3N2 X-31 Hemagglutinin in complex with FL-1061 Homo sapiens; Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Windsor, I.W., Thornlow, D., Schmidt, A.G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV16 Kappa None None None None None 8g5b J N 0 A protein NA hemagglutinin VIRAL PROTEIN 02/21/24 Influenza A H3N2 X-31 Hemagglutinin in complex with FL-1061 Homo sapiens; Influenza A virus; Mus musculus homo sapiens homo sapiens influenza a virus Windsor, I.W., Thornlow, D., Schmidt, A.G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8g70 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 H NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 I NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 G NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 F NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 K NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 N NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 O NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g70 M NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/nanobody mixture complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g76 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb5 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g76 H NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb5 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g76 I NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb5 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g77 G NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb6 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g77 F NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb6 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g77 K NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb6 complex Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g78 J NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g78 F NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g78 G NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g78 H NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g78 I NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g78 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around NTD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g79 N NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 6.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g79 O NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 6.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g79 M NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Local refinement of SARS-CoV-2 spike/nanobody mixture complex around RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 6.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7a E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 (local refinement) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7a C NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 (local refinement) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7a F NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 (local refinement) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7b E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb3 complex with 1 RBD up and 2 Nb3 (local refinement) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7b C NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 SARS-CoV-2 spike/Nb3 complex with 1 RBD up and 2 Nb3 (local refinement) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7c E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 local refinement of SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7c G NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 local refinement of SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g7c F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/21/24 local refinement of SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8oq3 C NA 0 A protein NA complement c3 IMMUNE SYSTEM 02/21/24 Structure of methylamine treated human complement C3 Homo sapiens; Lama glama lama glama homo sapiens Gadeberg, T.A.F., Andersen, G.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8oq3 F NA 0 D protein NA complement c3 IMMUNE SYSTEM 02/21/24 Structure of methylamine treated human complement C3 Homo sapiens; Lama glama lama glama homo sapiens Gadeberg, T.A.F., Andersen, G.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8pwh B A 0 E protein NA receptor tyrosine-protein kinase erbb-2 STRUCTURAL PROTEIN 02/21/24 Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex Homo sapiens homo sapiens homo sapiens homo sapiens Ruedas, R., Vuillemot, R., Tubiana, T., Winter, J.M., Pieri, L., Arteni, A.A., Samson, C., Jonic, J., Mathieu, M., Bressanelli, S. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8pwh D C 0 E protein NA receptor tyrosine-protein kinase erbb-2 STRUCTURAL PROTEIN 02/21/24 Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex Homo sapiens homo sapiens homo sapiens homo sapiens Ruedas, R., Vuillemot, R., Tubiana, T., Winter, J.M., Pieri, L., Arteni, A.A., Samson, C., Jonic, J., Mathieu, M., Bressanelli, S. 3.17 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8smv N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/21/24 GPR161 Gs heterotrimer Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Hoppe, N., Manglik, A., Harrison, S. 2.74 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8vfu B A 0 NA NA NA NA IMMUNE SYSTEM 02/21/24 The Fab Crystal Structure of the PAN IL-1 Family Inhibitor Antibody 3G5 Homo sapiens homo sapiens homo sapiens Fields, J.K., Sundberg, E.J. 2.45 X-RAY DIFFRACTION 0.256 0.213 False True IGHV5 IGKV12 Kappa None None None None None 8ssz G F 0 C protein NA neuronal acetylcholine receptor subunit beta-2 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kang, G., Hibbs, R.E. 2.64 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8ssz I H 0 B | A protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.64 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8ssz K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.64 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st0 G F 0 C protein NA neuronal acetylcholine receptor subunit beta-2 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kang, G., Hibbs, R.E. 2.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st0 I H 0 B | A protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st0 K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of full-length human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st1 G F 0 C | B protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 3.41 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st1 K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 3.41 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st2 G F 0 C | B protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.94 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st2 K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.94 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st3 G F 0 C protein NA neuronal acetylcholine receptor subunit beta-2 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kang, G., Hibbs, R.E. 2.93 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st3 I H 0 B | A protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.93 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st3 K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.93 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st4 G F 0 C protein NA neuronal acetylcholine receptor subunit beta-2 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kang, G., Hibbs, R.E. 2.35 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st4 I H 0 B | A protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.35 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8st4 K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 02/07/24 The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Kang, G., Hibbs, R.E. 2.35 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 8cbd H L 0 R protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-1 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.52 X-RAY DIFFRACTION 0.266 0.218 False True IGHV4 IGKV1 Kappa None None None None None 8cbd E F 0 R protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-1 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.52 X-RAY DIFFRACTION 0.266 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8cbd G I 0 Y protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-1 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.52 X-RAY DIFFRACTION 0.266 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8cbd J K 0 X protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-1 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.52 X-RAY DIFFRACTION 0.266 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8cbd A B 0 X protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-1 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.52 X-RAY DIFFRACTION 0.266 0.218 False True IGHV4 IGKV1 Kappa None None None None None 8cbd C D 0 Y protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-1 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.52 X-RAY DIFFRACTION 0.266 0.218 False True IGHV4 IGKV1 Kappa None None None None None 8cbe H L 0 E protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-2 and Beta-49 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.16 X-RAY DIFFRACTION 0.266 0.226 False True IGHV3 IGKV3 Kappa None None None None None 8cbe A B 0 E protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with BA.4/5-2 and Beta-49 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.16 X-RAY DIFFRACTION 0.266 0.226 False True IGHV1 IGKV3 Kappa None None None None None 8cbf A B 0 E protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with Omi-42 and Beta-49 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.33 X-RAY DIFFRACTION 0.255 0.215 False True IGHV1 IGKV3 Kappa None None None None None 8cbf H L 0 E protein NA spike protein s1 VIRAL PROTEIN 02/07/24 SARS-CoV-2 Delta-RBD complexed with Omi-42 and Beta-49 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.33 X-RAY DIFFRACTION 0.255 0.215 False True IGHV3 IGLV2 Lambda None None None None None 8cd0 C NA 0 A protein NA bifunctional heparan sulfate n-deacetylase/n-sulfotransferase 1 CARBOHYDRATE 02/07/24 Human heparan sulfate N-deacetylase-N-sulfotransferase 1 in complex with calcium, 3'-phosphoadenosine-5'-phosphosulfate, and nanobody nAb7 (composite map and model) Homo sapiens; Lama glama lama glama homo sapiens Mycroft-West, C.J., Wu, L. 2.42 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ds7 H L 0 M peptide NA acnliveghc peptide ANTITUMOR PROTEIN 02/07/24 Tumor-activated antibody derivatives targeting CTLA4 Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus phage 13 Johnson, P., Williams, J. 1.88 X-RAY DIFFRACTION 0.191 0.156 False True IGHV1 IGKV1 Kappa None None None None None 8g2m H L 0 F peptide NA masking peptide IMMUNE SYSTEM 02/14/24 The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus peptide display vector fth1 Williams, J.C., Williams, J.C. 1.8 X-RAY DIFFRACTION 0.214 0.180 False True IGHV1 IGKV6 Kappa None None None None None 8hyl A B 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of DO1 Fv-clasp fragment Mus musculus mus musculus mus musculus Anan, Y., Lu, P., Nagata, K., Itakura, M., Uchida, K. 2 X-RAY DIFFRACTION 0.298 0.241 False True IGHV1 IGKV1 Kappa None None None None None 8hyl C D 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of DO1 Fv-clasp fragment Mus musculus mus musculus mus musculus Anan, Y., Lu, P., Nagata, K., Itakura, M., Uchida, K. 2 X-RAY DIFFRACTION 0.298 0.241 False True IGHV1 IGKV1 Kappa None None None None None 8i7v E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/07/24 Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Park, J.H., Ishimoto, N., Park, S.Y. 2.77 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8i7w E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/07/24 Cryo-EM structure of GSK256073 bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Park, J.H., Ishimoto, N., Park, S.Y. 3.39 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ia6 A a 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of scFv antibody against Phospholipase A2 of Echis carinatus venom Homo sapiens homo sapiens Kumar, A., Madni, Z.K., Salunke, D.M. 2.75 X-RAY DIFFRACTION 0.264 0.232 True True unknown unknown unknown None None None None None 8ia6 B b 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of scFv antibody against Phospholipase A2 of Echis carinatus venom Homo sapiens homo sapiens Kumar, A., Madni, Z.K., Salunke, D.M. 2.75 X-RAY DIFFRACTION 0.264 0.232 True True unknown unknown unknown None None None None None 8iec N n 0 C | D protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/14/24 Cryo-EM structure of miniGo-scFv16 of GPR156-miniGo-scFv16 complex (local refine) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Shin, J., Park, J., Cho, Y. 3.18 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ied N n 0 C | D protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/14/24 Cryo-EM structure of GPR156-miniGo-scFv16 complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Shin, J., Park, J., Cho, Y. 3.33 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jbg E e 0 C | D protein | protein NA | NA guanine nucleotide-binding protein gq (g324) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Sun, W.J., Yang, F., Zhang, H.H., Yuan, Q.N., Yin, W.C., Shi, P., Eric, X., Tian, C.L. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jbh E e 0 C | D protein | protein NA | NA guanine nucleotide-binding protein gq subunit alpha (g324) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/08/09 Substance P bound to active human neurokinin 3 receptor in complex with Gq Bos taurus; Homo sapiens; Mus musculoides; Rattus norvegicus mus musculoides homo sapiens | rattus norvegicus Sun, W.J., Yang, F., Zhang, H.H., Yuan, Q.N., Yin, W.C., Shi, P., Eric, X., Tian, C.L. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8k8j N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/14/24 Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Tang, W.Q., Wang, T.X., Li, F.H., Wang, J.Y. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8kfx S s 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 02/07/24 Gi bound CCR8 complex with nonpeptide agonist LMD-009 Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens | homo sapiens Jiang, S., Lin, X., Wu, L.J., Xu, F. 2.96 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8kfy S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/07/24 Gi bound CCR8 complex with nonpeptide agonist ZK 756326 Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Jiang, S., Lin, X., Wu, L.J., Xu, F. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8kfz S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/07/24 Gi bound CCR8 in ligand free state Homo sapiens; synthetic construct homo sapiens homo sapiens | homo sapiens Jiang, S., Lin, X., Wu, L.J., Xu, F. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8odx H L 0 A protein NA interleukin-12 receptor subunit beta-1 CYTOKINE 02/07/24 Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb4 fragment and VHH. Homo sapiens; Homo sapiens x Mus musculus hybrid cell line; Lama glama homo sapiens x mus musculus hybrid cell line homo sapiens x mus musculus hybrid cell line homo sapiens Bloch, Y., Savvides, S.N. 4.4 X-RAY DIFFRACTION 0.312 0.280 False True IGHV3 IGKV1 Kappa None None None None None 8odx K NA 0 NA NA NA NA CYTOKINE 02/07/24 Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb4 fragment and VHH. Homo sapiens; Homo sapiens x Mus musculus hybrid cell line; Lama glama lama glama Bloch, Y., Savvides, S.N. 4.4 X-RAY DIFFRACTION 0.312 0.280 False True IGHV1 NA NA None None None None None 8ppm H L 0 NA NA NA NA IMMUNOSUPPRESSANT 02/07/24 IL-12Rb1 neutralizing Fab4, crystal kappa variant Homo sapiens x Mus musculus hybrid cell line homo sapiens x mus musculus hybrid cell line homo sapiens x mus musculus hybrid cell line Bloch, Y., Savvides, S.N. 2.03 X-RAY DIFFRACTION 0.220 0.193 False True IGHV3 IGKV1 Kappa None None None None None 8sip H L 0 H Hapten NOS INOSINE IMMUNE SYSTEM 02/07/24 Structure of a mouse IgG antibody fragment that binds Inosine, an RNA modification Mus musculus mus musculus mus musculus mus musculus Aoki, S.T. 1.94 X-RAY DIFFRACTION 0.245 0.204 False True IGHV9 IGKV8 Kappa None None None None None 8sxi C D 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 02/14/24 CH505 Disulfide Stapled SOSIP Bound to b12 Fab Human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Henderson, R. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8sxi G H 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 02/14/24 CH505 Disulfide Stapled SOSIP Bound to b12 Fab Human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Henderson, R. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8sxi K L 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 02/14/24 CH505 Disulfide Stapled SOSIP Bound to b12 Fab Human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Henderson, R. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8sxj C D 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 01/08/09 CH505 Disulfide Stapled SOSIP Bound to CH235.12 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R. 4.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8sxj G H 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 01/08/09 CH505 Disulfide Stapled SOSIP Bound to CH235.12 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R. 4.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8sxj K L 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 01/08/09 CH505 Disulfide Stapled SOSIP Bound to CH235.12 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R. 4.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8tca H L 0 NA NA NA NA IMMUNE SYSTEM 02/07/24 Structure of a mouse IgG antibody antigen-binding fragment (Fab) targeting N6-methyladenosine (m6A), an RNA modification, no ligand Mus musculus mus musculus mus musculus Angelo, M.C., Aoki, S.T. 2.02 X-RAY DIFFRACTION 0.224 0.181 False True IGHV6 IGLV1 Lambda None None None None None 8tjt D A 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 The Fab fragment of an anti-glucagon receptor (GCGR) antibody Homo sapiens homo sapiens homo sapiens Dai, J., Carter, P.J., Sudhamsu, J., Kung, J. 2.7 X-RAY DIFFRACTION 0.252 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8tjt E B 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 The Fab fragment of an anti-glucagon receptor (GCGR) antibody Homo sapiens homo sapiens homo sapiens Dai, J., Carter, P.J., Sudhamsu, J., Kung, J. 2.7 X-RAY DIFFRACTION 0.252 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8tjt F C 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 The Fab fragment of an anti-glucagon receptor (GCGR) antibody Homo sapiens homo sapiens homo sapiens Dai, J., Carter, P.J., Sudhamsu, J., Kung, J. 2.7 X-RAY DIFFRACTION 0.252 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8tjt H L 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 The Fab fragment of an anti-glucagon receptor (GCGR) antibody Homo sapiens homo sapiens homo sapiens Dai, J., Carter, P.J., Sudhamsu, J., Kung, J. 2.7 X-RAY DIFFRACTION 0.252 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8uf7 B A 0 C protein NA prothrombin BLOOD CLOTTING 02/14/24 Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Kumar, S., Summers, B., Basore, K., Pozzi, N. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8vev A B 0 NA NA NA NA IMMUNE SYSTEM 02/07/24 Structure of a mouse IgG antibody antigen-binding fragment (Fab) targeting N6-methyladenosine (m6A), an RNA modification, m6A nucleoside ligand Mus musculus mus musculus mus musculus Aoki, S.T. 3.06 X-RAY DIFFRACTION 0.253 0.224 False True IGHV6 IGLV1 Lambda None None None None None 8vev C D 0 NA NA NA NA IMMUNE SYSTEM 02/07/24 Structure of a mouse IgG antibody antigen-binding fragment (Fab) targeting N6-methyladenosine (m6A), an RNA modification, m6A nucleoside ligand Mus musculus mus musculus mus musculus Aoki, S.T. 3.06 X-RAY DIFFRACTION 0.253 0.224 False True IGHV6 IGLV1 Lambda None None None None None 8vev H L 0 NA NA NA NA IMMUNE SYSTEM 02/07/24 Structure of a mouse IgG antibody antigen-binding fragment (Fab) targeting N6-methyladenosine (m6A), an RNA modification, m6A nucleoside ligand Mus musculus mus musculus mus musculus Aoki, S.T. 3.06 X-RAY DIFFRACTION 0.253 0.224 False True IGHV6 IGLV1 Lambda None None None None None 8ww2 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/14/24 GPR3/Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Xiong, Y. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8xj0 B A 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of AmFab mutant - P40C/E165C (Light chain), G10C/P210C(Heavy chain) Homo sapiens homo sapiens homo sapiens Senda, M., Yoshikawa, M., Nakamura, H., Ohkuri, T., Senda, T. 3.3 X-RAY DIFFRACTION 0.268 0.186 False True IGHV3 IGKV1 Kappa None None None None None 8xj0 D C 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of AmFab mutant - P40C/E165C (Light chain), G10C/P210C(Heavy chain) Homo sapiens homo sapiens homo sapiens Senda, M., Yoshikawa, M., Nakamura, H., Ohkuri, T., Senda, T. 3.3 X-RAY DIFFRACTION 0.268 0.186 False True IGHV3 IGKV1 Kappa None None None None None 8xj0 F E 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of AmFab mutant - P40C/E165C (Light chain), G10C/P210C(Heavy chain) Homo sapiens homo sapiens homo sapiens Senda, M., Yoshikawa, M., Nakamura, H., Ohkuri, T., Senda, T. 3.3 X-RAY DIFFRACTION 0.268 0.186 False True IGHV3 IGKV1 Kappa None None None None None 8xj0 H G 0 NA NA NA NA IMMUNE SYSTEM 02/14/24 Crystal structure of AmFab mutant - P40C/E165C (Light chain), G10C/P210C(Heavy chain) Homo sapiens homo sapiens homo sapiens Senda, M., Yoshikawa, M., Nakamura, H., Ohkuri, T., Senda, T. 3.3 X-RAY DIFFRACTION 0.268 0.186 False True IGHV3 IGKV1 Kappa None None None None None 8i5l D d 0 A protein NA capsid protein VIRAL PROTEIN 01/31/24 Crystal structure of P domain from norovirus GI.4 capsid protein in complex with broad specificity antibody single-chain Fv fragment CV-2F5. Homo sapiens; Norovirus GI.4 homo sapiens norovirus gi.4 Kato-Murayama, M., Murayama, K., Shirouzu, M. 2.7 X-RAY DIFFRACTION 0.259 0.184 True True unknown unknown unknown None None None None None 8i5l E e 0 B | C protein | protein NA | NA capsid protein | capsid protein VIRAL PROTEIN 01/31/24 Crystal structure of P domain from norovirus GI.4 capsid protein in complex with broad specificity antibody single-chain Fv fragment CV-2F5. Homo sapiens; Norovirus GI.4 homo sapiens norovirus gi.4 | norovirus gi.4 Kato-Murayama, M., Murayama, K., Shirouzu, M. 2.7 X-RAY DIFFRACTION 0.259 0.184 True True unknown unknown unknown None None None None None 7yoy E I 0 C protein NA soluble gp42 VIRAL PROTEIN 01/31/24 Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement) Human gammaherpesvirus 4; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus human gammaherpesvirus 4 Liu, L., Sun, H., Jiang, Y., Hong, J., Zheng, Q., Li, S., Chen, Y., Xia, N. 3.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7yoy F J 0 C protein NA soluble gp42 VIRAL PROTEIN 01/31/24 Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement) Human gammaherpesvirus 4; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus human gammaherpesvirus 4 Liu, L., Sun, H., Jiang, Y., Hong, J., Zheng, Q., Li, S., Chen, Y., Xia, N. 3.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7yp1 D G 0 B | A protein | protein NA | NA ebv gl | ebv gh VIRAL PROTEIN 01/31/24 Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement) Human gammaherpesvirus 4; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus human gammaherpesvirus 4 | human gammaherpesvirus 4 Liu, L., Sun, H., Jiang, Y., Hong, J., Zheng, Q., Li, S., Chen, Y., Xia, N. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7yp2 H L 0 A protein NA envelope glycoprotein h VIRAL PROTEIN 01/31/24 Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement) Human gammaherpesvirus 4; Mus musculus mus musculus mus musculus human gammaherpesvirus 4 Liu, L., Sun, H., Jiang, Y., Hong, J., Zheng, Q., Li, S., Chen, Y., Xia, N. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV8 Kappa None None None None None 8c7m C D 0 B protein NA interleukin-12 receptor subunit beta-1 CYTOKINE 01/31/24 Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment. Homo sapiens; Homo sapiens x Mus musculus hybrid cell line homo sapiens x mus musculus hybrid cell line homo sapiens x mus musculus hybrid cell line homo sapiens Bloch, Y., Savvides, S.N. 2.56 X-RAY DIFFRACTION 0.228 0.203 False True IGHV3 IGKV1 Kappa None None None None None 8c7m H L 0 A protein NA interleukin-12 receptor subunit beta-1 CYTOKINE 01/31/24 Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment. Homo sapiens; Homo sapiens x Mus musculus hybrid cell line homo sapiens x mus musculus hybrid cell line homo sapiens x mus musculus hybrid cell line homo sapiens Bloch, Y., Savvides, S.N. 2.56 X-RAY DIFFRACTION 0.228 0.203 False True IGHV3 IGKV1 Kappa None None None None None 8hp9 H L 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hp9 M N 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hp9 P Q 0 B protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hp9 E F 0 B protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hp9 I J 0 C protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hp9 K O 0 C protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hpq H L 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpq M N 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hpq P Q 0 B protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpq E F 0 B protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hpq I J 0 C protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpq R S 0 C protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hpv M N 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hpv H L 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpv P Q 0 B protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpv E F 0 B protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hpv I J 0 C protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpv R S 0 C protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 01/31/24 Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i4h B NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/31/24 Omicron spike variant BA.1 with Bn03 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A.H., Zhang, X., Chen, Z.G., Sun, L. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8ipc H L 0 A protein NA putative zinc metalloprotease aq_1964 IMMUNE SYSTEM/HYDROLASE 01/31/24 The recombinant NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 181 and 184 Aquifex aeolicus VF5; Rattus norvegicus rattus norvegicus rattus norvegicus aquifex aeolicus vf5 Adachi, Y., Nogi, T. 2.2 X-RAY DIFFRACTION 0.270 0.243 False True IGHV5 IGLV3 Lambda None None None None None 8iq4 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/31/24 Cryo-EM structure of Carboprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Lv, X., Gao, K., Nie, J., Zhang, X., Zhang, S., Ren, Y., Li, Q., Huang, J., Liu, L., Zhang, X., Sun, X., Zhang, W., Liu, X. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8iq6 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/31/24 Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Lv, X., Gao, K., Nie, J., Zhang, X., Zhang, S., Ren, Y., Li, Q., Huang, J., Liu, L., Zhang, X., Sun, X., Zhang, W., Liu, X. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8p88 C A 0 NA NA NA NA IMMUNE SYSTEM 01/31/24 X-ray structure of cardiotoxic light chain H3 in complex to neutralizing nanobody C4 Homo sapiens; Lama glama lama glama homo sapiens Broggini, L., Ricagno, S. 2.022 X-RAY DIFFRACTION 0.233 0.222 False True IGHV3 IGLV1 Lambda None None None None None 8p89 C A 0 NA NA NA NA IMMUNE SYSTEM 01/31/24 X-ray structure of cardiotoxic light chain H3 in complex to neutralizing nanobody B5 Homo sapiens; Lama glama lama glama homo sapiens Broggini, L., Ricagno, S. 3.187 X-RAY DIFFRACTION 0.276 0.229 False True IGHV3 IGLV1 Lambda None None None None None 8p89 D B 0 NA NA NA NA IMMUNE SYSTEM 01/31/24 X-ray structure of cardiotoxic light chain H3 in complex to neutralizing nanobody B5 Homo sapiens; Lama glama lama glama homo sapiens Broggini, L., Ricagno, S. 3.187 X-RAY DIFFRACTION 0.276 0.229 False True IGHV3 IGLV1 Lambda None None None None None 8qpr E D 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 01/31/24 SARS-CoV-2 S protein bound to human neutralising antibody UZGENT_G5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Remaut, H., Reiter, D., Vandenkerckhove, L., Acar, D.D., Witkowski, W., Gerlo, S. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8qq0 E D 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 01/31/24 SARS-CoV-2 S protein bound to neutralising antibody UZGENT_A3 Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Remaut, H., Reiter, D., Vandenkerckhove, L., Acar, D.D., Witkowski, W., Gerlo, S. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8rcq B NA 0 A protein NA nucleoprotein VIRAL PROTEIN 01/31/24 Structural flexibility of Nucleoprotein of the Toscana virus in the presence of a nanobody. Lama glama; Toscana virus lama glama toscana virus Papageorgiou, N., Ferron, F., Coutard, B., Lichiere, J., Baklouti, A. 3.8 X-RAY DIFFRACTION 0.350 0.300 False True IGHV1 NA NA None None None None None 8the H L 0 A protein NA heme/hemoglobin uptake outer membrane receptor phur MEMBRANE PROTEIN 01/08/09 Cryo-EM structure of Pseudomonas aeruginosa TonB-dependent transporter PhuR in complex with synthetic antibody and heme Homo sapiens; Pseudomonas aeruginosa homo sapiens homo sapiens pseudomonas aeruginosa Knejski, P., Erramilli, S.K., Kossiakoff, A.A. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8bw0 H L 0 C protein NA carcinoembryonic antigen-related cell adhesion molecule 5 CELL ADHESION 01/24/24 Structure of CEACAM5 A3-B3 domain in Complex with Tusamitamab Fab Homo sapiens; Mus sp. mus sp. mus sp. homo sapiens Kumar, A., Bertrand, T., Rapisarda, C., Rak, A. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV12 Kappa None None None None None 8g72 A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb2 complex with 1 RBD up (local refinement at 5.6 A) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 5.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g73 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 bound at 2.5 A Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g73 C NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 bound at 2.5 A Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g73 F NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb3 complex with 2 RBDs up and 3 Nb3 bound at 2.5 A Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g74 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb3 complex with 1 RBD up and 2 Nb3 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g74 C NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb3 complex with 1 RBD up and 2 Nb3 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g75 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g75 G NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g75 F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ye, G., Bu, F., Liu, B., Li, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8j20 B b 0 C | A protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/24 Cryo-EM structure of FFAR3 bound with valeric acid and AR420626 Homo sapiens homo sapiens homo sapiens | homo sapiens Tai, L., Li, F., Sun, X., Tang, W., Wang, J. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j21 B b 0 C | A protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/24 Cryo-EM structure of FFAR3 complex bound with butyrate acid Homo sapiens homo sapiens homo sapiens | homo sapiens Tai, L., Li, F., Sun, X., Tang, W., Wang, J. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j22 F f 0 B | A protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/24 Cryo-EM structure of FFAR2 complex bound with TUG-1375 Homo sapiens homo sapiens homo sapiens | homo sapiens Tai, L., Li, F., Sun, X., Tang, W., Wang, J. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j24 G g 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/24 Cryo-EM structure of FFAR2 complex bound with acetic acid Homo sapiens homo sapiens homo sapiens | homo sapiens Tai, L., Li, F., Tang, W., Sun, X., Wang, J. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jlw H L 0 A protein NA glycoprotein c,cchfv envelope protein gc fusion loops VIRAL PROTEIN 01/24/24 CCHFV envelope protein Gc in complex with Gc8 Crimean-Congo hemorrhagic fever orthonairovirus; Mus musculus mus musculus mus musculus crimean-congo hemorrhagic feverorthonairovirus Chong, T., Cao, S. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV12 Kappa None None None None None 8jlx H L 0 A protein NA glycoprotein c,cchfv gc fusion loops VIRAL PROTEIN 01/24/24 CCHFV envelope protein Gc in complex with Gc13 Crimean-Congo hemorrhagic fever orthonairovirus; Mus musculus mus musculus mus musculus crimean-congo hemorrhagic feverorthonairovirus Chong, T., Cao, S. 3.0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 8jnk I M 0 A protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 RNA BINDING PROTEIN 01/24/24 Crystal structure of human ALKBH3 bound to ssDNA through active site crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 2.69 X-RAY DIFFRACTION 0.229 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8jnk J N 0 E protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 RNA BINDING PROTEIN 01/24/24 Crystal structure of human ALKBH3 bound to ssDNA through active site crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 2.69 X-RAY DIFFRACTION 0.229 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8jnk K O 0 G protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 RNA BINDING PROTEIN 01/24/24 Crystal structure of human ALKBH3 bound to ssDNA through active site crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 2.69 X-RAY DIFFRACTION 0.229 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8jnk L P 0 C protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 RNA BINDING PROTEIN 01/24/24 Crystal structure of human ALKBH3 bound to ssDNA through active site crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 2.69 X-RAY DIFFRACTION 0.229 0.218 False True IGHV3 IGKV1 Kappa None None None None None 8jnr G K 0 A protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 DNA BINDING PROTEIN/DNA 01/24/24 Crystal structure of human ALKBH3 bound to 3mC containing ssDNA through distal crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 3.66 X-RAY DIFFRACTION 0.273 0.227 False True IGHV3 IGKV1 Kappa None None None None None 8jnr H L 0 D protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 DNA BINDING PROTEIN/DNA 01/24/24 Crystal structure of human ALKBH3 bound to 3mC containing ssDNA through distal crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 3.66 X-RAY DIFFRACTION 0.273 0.227 False True IGHV3 IGKV1 Kappa None None None None None 8jnr I M 0 E protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 DNA BINDING PROTEIN/DNA 01/24/24 Crystal structure of human ALKBH3 bound to 3mC containing ssDNA through distal crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 3.66 X-RAY DIFFRACTION 0.273 0.227 False True IGHV3 IGKV1 Kappa None None None None None 8jnr J N 0 C protein NA alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 DNA BINDING PROTEIN/DNA 01/24/24 Crystal structure of human ALKBH3 bound to 3mC containing ssDNA through distal crosslink Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, L. 3.66 X-RAY DIFFRACTION 0.273 0.227 False True IGHV3 IGKV1 Kappa None None None None None 8k3k D NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 The crystal structure of nanobody Nb4 in complex with receptor binding domain (RBD) of BA.1 Spike protein Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Wang, H.Y., Xu, W.Q. 2.43 X-RAY DIFFRACTION 0.269 0.224 False True IGHV1 NA NA None None None None None 8t3q N n 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 01/24/24 Cryo-EM structure of the DHA bound FFA4-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Zhang, X., Tikhonova, I., Milligan, G., Zhang, C. 3.14 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8t3s N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/24 Cryo-EM structure of the Butyrate bound FFA2-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, X., Tikhonova, I., Milligan, G., Zhang, C. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8t3v N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/24 Cryo-EM structure of the DHA bound FFA1-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, X., Tikhonova, I., Milligan, G., Zhang, C. 3.39 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8tw3 A NA 0 F protein NA fusion glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 hMPV fusion protein complexed with single domain antibodies sdHMPV16 and sdHMPV12 Human metapneumovirus A; Lama glama lama glama human metapneumovirus a Rush, S.A., McLellan, J.S. 2.9 X-RAY DIFFRACTION 0.232 0.191 False True IGHV1 NA NA None None None None None 8tw3 B NA 0 F protein NA fusion glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 hMPV fusion protein complexed with single domain antibodies sdHMPV16 and sdHMPV12 Human metapneumovirus A; Lama glama lama glama human metapneumovirus a Rush, S.A., McLellan, J.S. 2.9 X-RAY DIFFRACTION 0.232 0.191 False True IGHV1 NA NA None None None None None 8tw3 Y NA 0 X protein NA fusion glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 hMPV fusion protein complexed with single domain antibodies sdHMPV16 and sdHMPV12 Human metapneumovirus A; Lama glama lama glama human metapneumovirus a Rush, S.A., McLellan, J.S. 2.9 X-RAY DIFFRACTION 0.232 0.191 False True IGHV1 NA NA None None None None None 8tw3 Z NA 0 X protein NA fusion glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 hMPV fusion protein complexed with single domain antibodies sdHMPV16 and sdHMPV12 Human metapneumovirus A; Lama glama lama glama human metapneumovirus a Rush, S.A., McLellan, J.S. 2.9 X-RAY DIFFRACTION 0.232 0.191 False True IGHV1 NA NA None None None None None 8wej H L 0 B protein NA cytochrome b-245 heavy chain OXIDOREDUCTASE 01/24/24 Structure of human phagocyte NADPH oxidase in the activated state Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chen, L., Liu, X. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV10 Kappa None None None None None 8x2l H L 0 B protein NA cytochrome b-245 heavy chain OXIDOREDUCTASE 01/24/24 Structure of human phagocyte NADPH oxidase in the resting state in the presence of 2 mM NADPH Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chen, L., Liu, X. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV10 Kappa None None None None None 8xc4 C D 0 B protein NA glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 Nipah virus attachment glycoprotein head domain in complex with a broadly neutralizing antibody 1E5 Henipavirus nipahense; Macaca mulatta macaca mulatta macaca mulatta henipavirus nipahense Fan, P.F., Yu, C.M., Chen, W. 3.24 X-RAY DIFFRACTION 0.247 0.218 False True IGHV4 IGKV1 Kappa None None None None None 8xc4 E F 0 A protein NA glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/24/24 Nipah virus attachment glycoprotein head domain in complex with a broadly neutralizing antibody 1E5 Henipavirus nipahense; Macaca mulatta macaca mulatta macaca mulatta henipavirus nipahense Fan, P.F., Yu, C.M., Chen, W. 3.24 X-RAY DIFFRACTION 0.247 0.218 False True IGHV4 IGKV1 Kappa None None None None None 8acf H L 0 A protein NA complement c2b fragment IMMUNE SYSTEM 01/17/24 Structure of the argX-117 in complex with a complement C2 fragment at low pH Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Olesen, H.G., Andersen, G.R. 1.8 X-RAY DIFFRACTION 0.199 0.178 False True IGHV1 IGKV3 Kappa None None None None None 8acf K NA 0 NA NA NA NA IMMUNE SYSTEM 01/17/24 Structure of the argX-117 in complex with a complement C2 fragment at low pH Homo sapiens; Lama glama lama glama Olesen, H.G., Andersen, G.R. 1.8 X-RAY DIFFRACTION 0.199 0.178 False True IGHV1 NA NA None None None None None 8aci H L 0 A protein NA complement c2b fragment IMMUNE SYSTEM 01/17/24 Structure of ARG-117 Fab in complex with a fragment of complement C2, neutral pH Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Olesen, H.G., Andersen, G.R. 1.85 X-RAY DIFFRACTION 0.199 0.187 False True IGHV1 IGKV3 Kappa None None None None None 8aci K NA 0 NA NA NA NA IMMUNE SYSTEM 01/17/24 Structure of ARG-117 Fab in complex with a fragment of complement C2, neutral pH Homo sapiens; Lama glama lama glama Olesen, H.G., Andersen, G.R. 1.85 X-RAY DIFFRACTION 0.199 0.187 False True IGHV1 NA NA None None None None None 8fhy H L 0 I protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5021 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 2.53 X-RAY DIFFRACTION 0.256 0.195 False True IGHV4 IGKV1 Kappa None None None None None 8fhy C B 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5021 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 2.53 X-RAY DIFFRACTION 0.256 0.195 False True IGHV4 IGKV1 Kappa None None None None None 8fhy F E 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5021 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 2.53 X-RAY DIFFRACTION 0.256 0.195 False True IGHV4 IGKV1 Kappa None None None None None 8fi9 G F 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5001 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 4.2 X-RAY DIFFRACTION 0.296 0.252 False True IGHV1 IGLV3 Lambda None None None None None 8fi9 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5001 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 4.2 X-RAY DIFFRACTION 0.296 0.252 False True IGHV1 IGLV3 Lambda None None None None None 8fi9 J I 0 O protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5001 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 4.2 X-RAY DIFFRACTION 0.296 0.252 False True IGHV1 IGLV3 Lambda None None None None None 8fi9 Q N 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5001 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 4.2 X-RAY DIFFRACTION 0.296 0.252 False True IGHV1 IGLV3 Lambda None None None None None 8g8n A B 0 C peptide NA cys-pro-gly-lys-gly-leu-pro-ser-cys IMMUNE SYSTEM 01/17/24 CTLA4 Fab with peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Williams, J.C. 3 X-RAY DIFFRACTION 0.288 0.239 False True IGHV1 IGKV6 Kappa None None None None None 8g8n D E 0 F peptide NA cys-pro-gly-lys-gly-leu-pro-ser-cys IMMUNE SYSTEM 01/17/24 CTLA4 Fab with peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Williams, J.C. 3 X-RAY DIFFRACTION 0.288 0.239 False True IGHV1 IGKV6 Kappa None None None None None 8g8n G I 0 J peptide NA cys-pro-gly-lys-gly-leu-pro-ser-cys IMMUNE SYSTEM 01/17/24 CTLA4 Fab with peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Williams, J.C. 3 X-RAY DIFFRACTION 0.288 0.239 False True IGHV1 IGKV6 Kappa None None None None None 8g8n H L 0 P peptide NA cys-pro-gly-lys-gly-leu-pro-ser-cys IMMUNE SYSTEM 01/17/24 CTLA4 Fab with peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Williams, J.C. 3 X-RAY DIFFRACTION 0.288 0.239 False True IGHV1 IGKV6 Kappa None None None None None 8g8n K M 0 Z peptide NA cys-pro-gly-lys-gly-leu-pro-ser-cys IMMUNE SYSTEM 01/17/24 CTLA4 Fab with peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Williams, J.C. 3 X-RAY DIFFRACTION 0.288 0.239 False True IGHV1 IGKV6 Kappa None None None None None 8g8n O Q 0 R peptide NA cys-pro-gly-lys-gly-leu-pro-ser-cys IMMUNE SYSTEM 01/17/24 CTLA4 Fab with peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Williams, J.C. 3 X-RAY DIFFRACTION 0.288 0.239 False True IGHV1 IGKV6 Kappa None None None None None 8hrx H L 0 B | A peptide | protein NA | NA pres1 protein (fragment) | sodium/bile acid cotransporter TRANSPORT PROTEIN 01/17/24 Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex Hepatitis B virus; Homo sapiens; Ondatra zibethicus ondatra zibethicus ondatra zibethicus hepatitis b virus | homo sapiens Asami, J., Shimizu, T., Ohto, U. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 8hry H L 0 B | A peptide | protein NA | NA large s protein (fragment) | sodium/bile acid cotransporter TRANSPORT PROTEIN 01/17/24 Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex Hepatitis B virus; Homo sapiens; Ondatra zibethicus ondatra zibethicus ondatra zibethicus hepatitis b virus | homo sapiens Asami, J., Shimizu, T., Ohto, U. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 8j9n N NA 0 C | D protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/17/24 Gq bound FZD1 in ligand-free state Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Lin, X., Xu, F. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8j9o B D 0 A protein NA frizzled-1,soluble cytochrome b562 MEMBRANE PROTEIN 01/17/24 Cryo-EM structure of inactive FZD1 Escherichia coli; Homo sapiens; Mus; Vicugna pacos mus mus homo sapiens, escherichia coli Lin, X., Xu, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j9o C NA 0 NA NA NA NA MEMBRANE PROTEIN 01/17/24 Cryo-EM structure of inactive FZD1 Escherichia coli; Homo sapiens; Mus; Vicugna pacos vicugna pacos Lin, X., Xu, F. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jh7 H L 0 D protein NA frizzled-6,soluble cytochrome b562 MEMBRANE PROTEIN 01/17/24 FZD6 in inactive state Escherichia coli; Homo sapiens; synthetic construct homo sapiens homo sapiens homo sapiens, escherichia coli Xu, F., Zhang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jh7 K NA 0 NA NA NA NA MEMBRANE PROTEIN 01/17/24 FZD6 in inactive state Escherichia coli; Homo sapiens; synthetic construct synthetic construct Xu, F., Zhang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jhb N NA 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms xlas | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 01/17/24 FZD6 Gs complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Xu, F., Zhang, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jhc H L 0 R protein NA frizzled-3,soluble cytochrome b562 MEMBRANE PROTEIN 01/17/24 FZD3 in inactive state Escherichia coli; Homo sapiens; synthetic construct homo sapiens homo sapiens homo sapiens, escherichia coli Xu, F., Zhang, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jhc K NA 0 NA NA NA NA MEMBRANE PROTEIN 01/17/24 FZD3 in inactive state Escherichia coli; Homo sapiens; synthetic construct synthetic construct Xu, F., Zhang, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8jhi N NA 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms xlas | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 01/17/24 FZD3-Gs complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Xu, F., Zhang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8qy9 H L 0 A peptide NA chains IMMUNE SYSTEM 01/17/24 J22.9-H, fully humanized Fab Fragment based on chimeric J22.9-xi IgG against BCMA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Marino, S.F., Daumke, O. 3.1 X-RAY DIFFRACTION 0.311 0.261 False True IGHV4 IGKV3 Kappa None None None None None 8qya H L 0 A peptide NA chains IMMUNE SYSTEM 01/17/24 J22.9-FNY, fully humanized, CDR optimized Fab Fragment based on chimeric J22.9-xi IgG against BCMA; with VH CDR2 glycosylation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Marino, S.F., Daumke, O. 2.72 X-RAY DIFFRACTION 0.297 0.244 False True IGHV4 IGKV3 Kappa None None None None None 8qyb H L 0 A peptide NA chains IMMUNE SYSTEM 01/17/24 J22.9-ISY, fully humanized and CDR optimized Fab Fragment based on chimeric J22.9-xi IgG against BCMA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Marino, S.F., Daumke, O. 3.09 X-RAY DIFFRACTION 0.306 0.247 False True IGHV4 IGKV3 Kappa None None None None None 8t3o N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/17/24 Cryo-EM structure of the TUG-891 bound FFA4-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, X., Tikhonova, I., Milligan, G., Zhang, C. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8thn A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 01/17/24 KcsA M96V mutant with Y78ester in High K+ Mus musculus; Streptomyces lividans mus musculus mus musculus streptomyces lividans Reddi, R., Valiyaveetil, F.I. 2.9 X-RAY DIFFRACTION 0.276 0.246 False True IGHV1 IGKV5 Kappa None None None None None 8tm1 H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Antibody N3-1 bound to RBDs in the up and down conformations Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Hsieh, C.-L., McLellan, J.S. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tma H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/17/24 Antibody N3-1 bound to RBD in the up conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hsieh, C.-L., McLellan, J.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8wdt C B 0 A protein NA adenosine receptor a2a MEMBRANE PROTEIN 01/17/24 Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Araya, T., Asada, H., Iwata, S., Im, D.H. 3.34 X-RAY DIFFRACTION 0.266 0.214 False False IGHV1 IGKV4 Kappa None None None None None 8t5c H L 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 01/03/24 Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5 Camelus bactrianus; Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Gorman, J., Kwong, P.D. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8t5c E I 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 01/03/24 Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5 Camelus bactrianus; Homo sapiens; Lassa virus Josiah homo sapiens homo sapiens lassa virus josiah Gorman, J., Kwong, P.D. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8t5c D NA 0 A | C | B protein | protein | protein NA | NA | NA glycoprotein g2 | glycoprotein g2 | glycoprotein g2 VIRAL PROTEIN/IMMUNE SYSTEM 01/03/24 Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5 Camelus bactrianus; Homo sapiens; Lassa virus Josiah camelus bactrianus lassa virus josiah | lassa virus josiah | lassa virus josiah Gorman, J., Kwong, P.D. 4.7 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8c3k B NA 0 A protein NA phage repressor protein ci DNA BINDING PROTEIN 01/10/24 PaaR2 N-terminal domin in complex with nanobody 33 Escherichia coli O157:H7; Lama glama lama glama escherichia coli o157 Loris, R., Prolic-Kalinsek, M. 1.74972 X-RAY DIFFRACTION 0.233 0.203 False True IGHV1 NA NA None None None None None 8c89 H L 0 C protein NA spike protein s2' VIRAL PROTEIN 01/10/24 SARS-CoV-2 spike in complex with the 17T2 neutralizing antibody Fab fragment (local refinement of RBD and Fab) Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Modrego, A., Carlero, D., Bueno-Carrasco, M.T., Santiago, C., Carolis, C., Arranz, R., Blanco, J., Magri, G. 4.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8gd9 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/10/24 Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Shenming, H., Mengyao, X., Lei, L., Yang, D., Sheng, C., Jinpeng, S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8gda N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/10/24 Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Shenming, H., Mengyao, X., Lei, L., Jiangqian, M., Sheng, C., Jinpeng, S. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8gdb N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/10/24 Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Shenming, H., Mengyao, X., Lei, L., Jianqiang, M., Jinpeng, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8j6j H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/10/24 Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073 Homo sapiens homo sapiens homo sapiens | homo sapiens Yuan, Q., Zhu, S., Duan, J., Xu, H.E., Duan, X. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jgb S s 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 01/10/24 CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens | homo sapiens Sun, J.P., Xu, H.E., Yang, F., Liu, Z.M., Guo, L.L., Zhang, Y.M., Fang, G.X., Tie, L., Zhuang, Y.M., Xue, C.Y. 2.84 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jgf E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein gq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 01/10/24 CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Sun, J.P., Xu, H.E., Yang, F., Liu, Z.M., Guo, L.L., Zhang, Y.M., Fang, G.X., Tie, L., Zhuang, Y.M., Xue, C.Y. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jgg S s 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 01/10/24 CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens | homo sapiens Sun, J.P., Xu, H.E., Ynag, F., Liu, Z.M., Guo, L.L., Zhang, Y.M., Fang, G.X., Tie, L., Zhuang, Y.M., Xue, C.Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jjv A NA 0 B peptide NA alpha-synuclein peptide IMMUNE SYSTEM 01/10/24 Structure of truncated form of nanobody in complex with alpha-synuclein peptide Camelus dromedarius; SYNTHETIC CONSTRUCT camelus dromedarius homo sapiens Islam, Z., Kolatkar, P.R. 1.23 X-RAY DIFFRACTION 0.170 0.142 False True IGHV1 NA NA None None None None None 8jly A NA 0 B peptide NA alpha-synuclein peptide IMMUNE SYSTEM 01/10/24 Structure of nanobody in complex with alpha-synuclein peptide Camelus dromedarius; SYNTHETIC CONSTRUCT camelus dromedarius homo sapiens Islam, Z., Kolatkar, P.R. 1.29 X-RAY DIFFRACTION 0.186 0.161 False True IGHV1 NA NA None None None None None 8t29 A B 0 R nucleic-acid NA rna (90-mer) RNA/IMMUNE SYSTEM 01/10/24 Crystal structure of SCV PTE RNA in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens saguaro cactus virus Ojha, M., Koirala, D. 3.13 X-RAY DIFFRACTION 0.233 0.179 False True IGHV3 IGKV1 Kappa None None None None None 8t2a A B 0 R nucleic-acid NA rna (90-mer) RNA/IMMUNE SYSTEM 01/10/24 Crystal structure of SCV PTE G18A mutant RNA in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens saguaro cactus virus Ojha, M., Koirala, D. 3.17 X-RAY DIFFRACTION 0.243 0.184 False True IGHV3 IGKV1 Kappa None None None None None 8t2b A B 0 R nucleic-acid NA rna (90-mer) RNA/IMMUNE SYSTEM 01/10/24 Crystal structure of SCV PTE G18C mutant RNA in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens saguaro cactus virus Ojha, M., Koirala, D. 3.18 X-RAY DIFFRACTION 0.241 0.198 False True IGHV3 IGKV1 Kappa None None None None None 8t2o A B 0 R nucleic-acid NA rna (90-mer) RNA/IMMUNE SYSTEM 01/10/24 Crystal structure of SCV PTE G18U RNA in complex with Fab BL3-6 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens saguaro cactus virus Ojha, M., Koirala, D. 3.29 X-RAY DIFFRACTION 0.243 0.176 False True IGHV3 IGKV1 Kappa None None None None None 8uhb N NA 0 C | A | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | soluble cytochrome b562,beta-2 adrenergic receptor,traceamine-associated receptor 1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/10/24 Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex Homo sapiens; Lama glama; Rattus norvegicus lama glama rattus norvegicus | homo sapiens | homo sapiens Zilberg, G., Warren, A.L., Parpounas, A.K., Wacker, D. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8coe B NA 0 C protein NA complement c5 beta chain IMMUNE SYSTEM 01/03/24 complement C5 in complex with the LCP0195 nanobody Homo sapiens; Lama glama lama glama homo sapiens Andersen, G.R., Pedersen, D.V. 4.2 X-RAY DIFFRACTION 0.269 0.248 False True IGHV3 NA NA None None None None None 8coh A NA 0 NA NA NA NA IMMUNE SYSTEM 01/03/24 Structure of the complement C5 specific nanobody TPP-3444 Lama glama lama glama Pedersen, D.V., Andersen, G.R. 1.3 X-RAY DIFFRACTION 0.175 0.146 False True IGHV3 NA NA None None None None None 8gcm E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein Homo sapiens homo sapiens homo sapiens | homo sapiens Huang, S.M., Xiong, M.Y., Liu, L., Mu, J., Sheng, C., Sun, J. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gcp E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein Homo sapiens homo sapiens homo sapiens | homo sapiens Huang, S.M., Xiong, M.Y., Liu, L., Mu, J., Sheng, C., Sun, J. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hbi E NA 0 A protein NA vp1 of capsid protein VIRUS 01/03/24 FMDV (A/TUR/14/98) in complex with M688F Foot-and-mouth disease virus A; Lama glama lama glama foot-and-mouth disease virus a Li, H.Z., Dong, H., Liu, P. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hxq A NA 0 C peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/03/24 Nanobody1 in complex with human BCMA ECD Vicugna pacos; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens Sun, Y., Zhang, B. 2.4 X-RAY DIFFRACTION 0.274 0.227 False True IGHV1 NA NA None None None None None 8hxq B NA 0 D peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/03/24 Nanobody1 in complex with human BCMA ECD Vicugna pacos; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens Sun, Y., Zhang, B. 2.4 X-RAY DIFFRACTION 0.274 0.227 False True IGHV1 NA NA None None None None None 8hxr B NA 0 D peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/03/24 Nanobody2 in complex with human BCMA ECD Vicugna pacos; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens Sun, Y., Zhang, B. 2.7 X-RAY DIFFRACTION 0.287 0.240 False True IGHV1 NA NA None None None None None 8hxr A NA 0 C peptide NA tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/03/24 Nanobody2 in complex with human BCMA ECD Vicugna pacos; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens Sun, Y., Zhang, B. 2.7 X-RAY DIFFRACTION 0.287 0.240 False True IGHV1 NA NA None None None None None 8ij3 S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state) Homo sapiens homo sapiens homo sapiens | homo sapiens Pan, X., Fang, Y. 3.28 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ija S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM structure of human HCAR2-Gi complex with niacin Homo sapiens homo sapiens homo sapiens | homo sapiens Pan, X., Fang, Y. 2.69 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ijb S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM structure of human HCAR2-Gi complex with acipimox Homo sapiens homo sapiens homo sapiens | homo sapiens Pan, X., Fang, Y. 3.23 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ijd S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM structure of human HCAR2-Gi complex with MK-6892 Homo sapiens homo sapiens homo sapiens | homo sapiens Pan, X., Fang, Y. 3.25 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8kae H L 0 R protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 01/03/24 16d-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct synthetic construct synthetic construct homo sapiens He, Y., Duan, Y. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8kae K NA 0 NA NA NA NA MEMBRANE PROTEIN 01/03/24 16d-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct lama glama He, Y., Duan, Y. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8kae N NA 0 R protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 01/03/24 16d-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens He, Y., Duan, Y. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8kfa H L 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of HSV-1 gB with D48 Fab complex Homo sapiens; Human herpesvirus 1 (strain KOS) homo sapiens homo sapiens human herpesvirus 1 (strain kos) Yang, J., Sun, C., Fang, X., Zeng, M., Liu, Z. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8kfa D F 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of HSV-1 gB with D48 Fab complex Homo sapiens; Human herpesvirus 1 (strain KOS) homo sapiens homo sapiens human herpesvirus 1 (strain kos) Yang, J., Sun, C., Fang, X., Zeng, M., Liu, Z. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8kfa E G 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of HSV-1 gB with D48 Fab complex Homo sapiens; Human herpesvirus 1 (strain KOS) homo sapiens homo sapiens human herpesvirus 1 (strain kos) Yang, J., Sun, C., Fang, X., Zeng, M., Liu, Z. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8u1d I J 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/03/24 Cryo-EM structure of vaccine-elicited CD4 binding site antibody DH1285 bound to HIV-1 CH505TFchim.6R.SOSIP.664v4.1 Env Local Refinement Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Thakur, B., Stalls, V.D., Acharya, P. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8w8q N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM structure of the GPR101-Gs complex Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Sun, J.P., Gao, N., Yu, X., Wang, G.P., Yang, F., Wang, J.Y., Yang, Z., Guan, Y. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8w8r S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/03/24 Cryo-EM structure of the AA-14-bound GPR101-Gs complex Homo sapiens homo sapiens homo sapiens | homo sapiens Sun, J.P., Yu, X., Gao, N., Yang, F., Wang, J.Y., Yang, Z., Guan, Y., Wang, G.P. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8cn9 B A 0 D | C protein | protein NA | NA coagulation factor vii | coagulation factor vii BLOOD CLOTTING 12/27/23 Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Schluckebier, G., Johansson, E. 3.4 X-RAY DIFFRACTION 0.356 0.303 False True IGHV4 IGKV3 Kappa None None None None None 8cn9 G F 0 I | H protein | protein NA | NA coagulation factor vii | coagulation factor vii BLOOD CLOTTING 12/27/23 Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Schluckebier, G., Johansson, E. 3.4 X-RAY DIFFRACTION 0.356 0.303 False True IGHV4 IGKV3 Kappa None None None None None 8cn9 L K 0 N | M protein | protein NA | NA coagulation factor vii | coagulation factor vii BLOOD CLOTTING 12/27/23 Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Schluckebier, G., Johansson, E. 3.4 X-RAY DIFFRACTION 0.356 0.303 False True IGHV4 IGKV3 Kappa None None None None None 8cn9 Q P 0 S | R protein | protein NA | NA coagulation factor vii | coagulation factor vii BLOOD CLOTTING 12/27/23 Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Schluckebier, G., Johansson, E. 3.4 X-RAY DIFFRACTION 0.356 0.303 False True IGHV4 IGKV3 Kappa None None None None None 8go9 B C 0 F | H protein | peptide NA | NA beta-arrestin-2 | atypical chemokine receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Atypical chemokine receptor 2, ACKR2 (D6R) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8go9 D E 0 A | G protein | peptide NA | NA beta-arrestin-2 | atypical chemokine receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Atypical chemokine receptor 2, ACKR2 (D6R) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j8r D E 0 A | G protein | peptide NA | NA beta-arrestin-2 | muscarinic acetylcholine receptor m2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin2 in complex with M2Rpp Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sano, F.K., Shihoya, W., Banerjee, R., Nureki, O., Shukla, A.K. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j8r H L 0 B | U protein | peptide NA | NA beta-arrestin-2 | muscarinic acetylcholine receptor m2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin2 in complex with M2Rpp Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sano, F.K., Shihoya, W., Banerjee, R., Nureki, O., Shukla, A.K. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j8r M N 0 C | V protein | peptide NA | NA beta-arrestin-2 | muscarinic acetylcholine receptor m2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin2 in complex with M2Rpp Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sano, F.K., Shihoya, W., Banerjee, R., Nureki, O., Shukla, A.K. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j8v B C 0 F | H protein | peptide NA | NA beta-arrestin-2 | atypical chemokine receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin2 in complex with D6Rpp (Local Refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Chami, M., Banerjee, R., Shukla, A.K. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j8v D E 0 A | G protein | peptide NA | NA beta-arrestin-2 | atypical chemokine receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin2 in complex with D6Rpp (Local Refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Chami, M., Banerjee, R., Shukla, A.K. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j8z H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | atypical chemokine receptor 2 SYGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin1 in complex with D6Rpp Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Chami, M., Banerjee, R., Shukla, A.K. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j8z I M 0 B | U protein | peptide NA | NA beta-arrestin-1 | atypical chemokine receptor 2 SYGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin1 in complex with D6Rpp Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Chami, M., Banerjee, R., Shukla, A.K. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ja3 I M 0 B | U protein | peptide NA | NA beta-arrestin-1 | c3a anaphylatoxin chemotactic receptor SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin1 in complex with C3aRpp Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Chami, M., Banerjee, R., Shukla, A.K. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ja3 H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | c3a anaphylatoxin chemotactic receptor SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of beta-arrestin1 in complex with C3aRpp Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Chami, M., Banerjee, R., Shukla, A.K. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8wc6 S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the PEA-bound mTAAR1-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wc6 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the PEA-bound mTAAR1-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7y3n H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/27/23 Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Rao, X., Chai, Y., Wu, Y., Gao, F. 2.97 X-RAY DIFFRACTION 0.263 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7y3n C D 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/27/23 Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Rao, X., Chai, Y., Wu, Y., Gao, F. 2.97 X-RAY DIFFRACTION 0.263 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7y3n F G 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/27/23 Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Rao, X., Chai, Y., Wu, Y., Gao, F. 2.97 X-RAY DIFFRACTION 0.263 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7y3o H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/27/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody BIOLS56 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rao, X., Gao, F., Wu, Y., Gao, F. 2.1 X-RAY DIFFRACTION 0.229 0.183 False True IGHV3 IGKV1 Kappa None None None None None 8b7h H L 0 A protein NA gremlin-1 SIGNALING PROTEIN 12/27/23 Crystal structure of human Gremlin-1 in complex with Fab Homo sapiens homo sapiens homo sapiens homo sapiens Schulze, M.-S., Martinez-Fleites, C. 1.95 X-RAY DIFFRACTION 0.275 0.265 False True IGHV1 IGKV4 Kappa None None None None None 8che H L 0 C peptide NA trem-like transcript 1 protein BLOOD CLOTTING 12/27/23 TLT-1 binding Fab of the bispecific antibody HMB-001 in complex with the TLT-1 stalk peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Johansson, E., Schluckebier, G. 1.49 X-RAY DIFFRACTION 0.174 0.157 False True IGHV3 IGKV2 Kappa None None None None None 8che A B 0 D peptide NA trem-like transcript 1 protein BLOOD CLOTTING 12/27/23 TLT-1 binding Fab of the bispecific antibody HMB-001 in complex with the TLT-1 stalk peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Johansson, E., Schluckebier, G. 1.49 X-RAY DIFFRACTION 0.174 0.157 False True IGHV3 IGKV2 Kappa None None None None None 8hj1 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 12/27/23 GPR21(wt) and Gs complex Homo sapiens homo sapiens homo sapiens | homo sapiens Chen, B., Lin, X., Xu, F. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8i4f C NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/27/23 Omicron spike variant XBB with n3130v-Fc Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A.H., Zhang, X., Chen, Z.G., Sun, L. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8i4g C NA 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/27/23 Omicron spike variant BQ.1.1 with n3130v-Fc Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hao, A.H., Zhang, X., Chen, Z.G., Sun, L. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8iiu A NA 0 NA NA NA NA ANTITUMOR PROTEIN 12/27/23 anti-VEGF nanobody Homo sapiens homo sapiens Qian, F., Zhu, S.Q. 1.27 X-RAY DIFFRACTION 0.187 0.167 False True IGHV3 NA NA None None None None None 8iiu B NA 0 NA NA NA NA ANTITUMOR PROTEIN 12/27/23 anti-VEGF nanobody Homo sapiens homo sapiens Qian, F., Zhu, S.Q. 1.27 X-RAY DIFFRACTION 0.187 0.167 False True IGHV3 NA NA None None None None None 8ijs A NA 0 NA NA NA NA ANTITUMOR PROTEIN-IMMUNE SYSTEM 12/27/23 anti-VEGF nanobody mutant Homo sapiens homo sapiens Qian, F., Zhu, S.Q. 1.752 X-RAY DIFFRACTION 0.220 0.201 False True IGHV3 NA NA None None None None None 8ijz A NA 0 NA NA NA NA ANTITUMOR PROTEIN-IMMUNE SYSTEM 12/27/23 anti-VEGF mutant Homo sapiens homo sapiens Qian, F., Zhu, S.Q. 2.1 ELECTRON CRYSTALLOGRAPHY NA NA False True IGHV3 NA NA None None None None None 8j97 H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | muscarinic acetylcholine receptor m2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked) Bos taurus; Homo sapiens; Mus musculus mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sano, F.K., Shihoya, W., Banerjee, R., Nureki, O., Shukla, A.K. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j9k D B 0 C protein NA beta-arrestin-2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of basal beta-arrestin2 Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Maharana, J., Sarma, P., Yadav, M.K., Chami, M., Banerjee, R., Shukla, A.K. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jaf H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | muscarinic acetylcholine receptor m2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local Refine, non-cross linked) Bos taurus; Homo sapiens; Mus musculus mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sano, F.K., Shihoya, W., Banerjee, R., Nureki, O., Shukla, A.K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8k5g H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of the SARS-CoV-2 BA.1 RBD with UT28-RD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, L., Kita, S., Anraku, Y., Maenaka, K. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8k5h H L 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/27/23 Structure of the SARS-CoV-2 BA.1 spike with UT28-RD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Chen, L., Kita, S., Anraku, Y., Maenaka, K. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8kad NA A 0 NA NA NA NA IMMUNE SYSTEM 12/27/23 Crystal structure of an antibody light chain tetramer with 3D domain swapping Homo sapiens homo sapiens Sakai, T., Mashima, T., Kobayashi, N., Ogata, H., Uda, T., Hifumi, E., Hirota, S. 2 X-RAY DIFFRACTION 0.296 0.253 False True NA IGKV2 Kappa None None None None None 8kad NA B 0 NA NA NA NA IMMUNE SYSTEM 12/27/23 Crystal structure of an antibody light chain tetramer with 3D domain swapping Homo sapiens homo sapiens Sakai, T., Mashima, T., Kobayashi, N., Ogata, H., Uda, T., Hifumi, E., Hirota, S. 2 X-RAY DIFFRACTION 0.296 0.253 False True NA IGKV2 Kappa None None None None None 8qot H L 0 A protein NA mu-type opioid receptor MEMBRANE PROTEIN 12/27/23 Structure of the mu opioid receptor bound to the antagonist nanobody NbE Lama glama; Mus musculus; synthetic construct synthetic construct synthetic construct mus musculus Yu, J., Kumar, A., Zhang, X., Martin, C., Raia, P., Manglik, A., Ballet, S., Boland, A., Stoeber, M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8qot B NA 0 A protein NA mu-type opioid receptor MEMBRANE PROTEIN 12/27/23 Structure of the mu opioid receptor bound to the antagonist nanobody NbE Lama glama; Mus musculus; synthetic construct lama glama mus musculus Yu, J., Kumar, A., Zhang, X., Martin, C., Raia, P., Manglik, A., Ballet, S., Boland, A., Stoeber, M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8qot K NA 0 NA NA NA NA MEMBRANE PROTEIN 12/27/23 Structure of the mu opioid receptor bound to the antagonist nanobody NbE Lama glama; Mus musculus; synthetic construct lama glama Yu, J., Kumar, A., Zhang, X., Martin, C., Raia, P., Manglik, A., Ballet, S., Boland, A., Stoeber, M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8wc3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wc4 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the ZH8651-bound mTAAR1-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wc5 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the TMA-bound mTAAR1-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wc7 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the ZH8667-bound mTAAR1-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wc8 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wc9 S s 0 A | B protein | protein NA | NA engineered g-alpha-q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wca S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the PEA-bound hTAAR1-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.48 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wcb S s 0 A | B protein | protein NA | NA engineered g-alpha-q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Cryo-EM structure of the CHA-bound mTAAR1-Gq complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Rong, N.K., Guo, L.L., Zhang, M.H., Li, Q., Yang, F., Sun, J.P. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8xbh S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/27/23 Human GPR34 -Gi complex bound to M1 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Kawahara, R., Shihoya, W., Nureki, O. 2.83 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8fif A NA 0 D peptide NA microcystin-lr IMMUNE SYSTEM 12/20/23 A2.3 Nanobody In Complex With Microcystin-LR Lama glama; SYNTHETIC CONSTRUCT lama glama synthetic construct Arenas, R., Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 2.35 X-RAY DIFFRACTION 0.280 0.236 False True IGHV1 NA NA None None None None None 8fif B NA 0 F peptide NA microcystin-lr IMMUNE SYSTEM 12/20/23 A2.3 Nanobody In Complex With Microcystin-LR Lama glama; SYNTHETIC CONSTRUCT lama glama synthetic construct Arenas, R., Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 2.35 X-RAY DIFFRACTION 0.280 0.236 False True IGHV1 NA NA None None None None None 8fif C NA 0 G peptide NA microcystin-lr IMMUNE SYSTEM 12/20/23 A2.3 Nanobody In Complex With Microcystin-LR Lama glama; SYNTHETIC CONSTRUCT lama glama synthetic construct Arenas, R., Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 2.35 X-RAY DIFFRACTION 0.280 0.236 False True IGHV1 NA NA None None None None None 8fja E D 0 A | C protein | peptide NA | NA mhc class i antigen | melanoma-associated antigen 4 peptide IMMUNE SYSTEM 12/20/23 CryoEM structure of HLA-A2 MAGEA4 (230-239) in complex with REGN6972 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Saotome, K., Franklin, M.C. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8fjb E D 0 A | C protein | peptide NA | NA mhc class i antigen | melanoma-associated antigen 4 peptide IMMUNE SYSTEM 12/20/23 CryoEM structure of HLA-A2 MAGEA4 (286-294) in complex with H2aM31345N Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Saotome, K., Franklin, M.C. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8g4p C D 0 E protein NA ara h 2 allergen ALLERGEN 12/20/23 Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 13T1 and 13T5 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.25 X-RAY DIFFRACTION 0.218 0.189 False True IGHV3 IGKV3 Kappa None None None None None 8g4p A B 0 E protein NA ara h 2 allergen ALLERGEN 12/20/23 Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 13T1 and 13T5 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Pedersen, L.C., Mueller, G.A., Min, J. 2.25 X-RAY DIFFRACTION 0.218 0.189 False True IGHV4 IGKV1 Kappa None None None None None 8hn1 D NA 0 A protein NA alpha-1a adrenergic receptor MEMBRANE PROTEIN 12/20/23 Cryo-EM structure of AdTx1-alpha1AAR-Nb6 Dendroaspis angusticeps; Homo sapiens; Lama glama lama glama homo sapiens Liu, X., Shi, M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hn8 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/20/23 Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Tang, W.Q., Sun, X.Y., Li, F.H., Wang, J.Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hoc S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/20/23 Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Tang, W.Q., Sun, X.Y., Li, F.H., Wang, J.Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hpf H L 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/20/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.34 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpf M N 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/20/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hpu H L 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/20/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 RBD in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hpu M N 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/20/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.4 RBD in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hq7 M N 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/20/23 Cryo-EM structure of SARS-CoV-2 Omicron Prototype RBD in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hq7 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/20/23 Cryo-EM structure of SARS-CoV-2 Omicron Prototype RBD in complex with fab L4.65 and L5.34 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Liu, S. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hrd O P 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV5 IGLV1 Lambda None None None None None 8hrd D F 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV4 IGKV1 Kappa None None None None None 8hrd C E 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV5 IGLV1 Lambda None None None None None 8hrd G H 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV4 IGKV1 Kappa None None None None None 8hrd L M 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV5 IGLV1 Lambda None None None None None 8hrd N Q 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV4 IGKV1 Kappa None None None None None 8hrd W X 0 T protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV5 IGLV1 Lambda None None None None None 8hrd Y Z 0 T protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/20/23 Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, R.C., Wu, L.L., Han, P. 2.86 X-RAY DIFFRACTION 0.244 0.212 False True IGHV4 IGKV1 Kappa None None None None None 8hti N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/20/23 Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Choi, C.W., Bae, J., Choi, H.-J., Kim, J. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8q7s B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s C NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s E NA 0 D protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s F NA 0 D protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s H NA 0 G protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s I NA 0 G protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s K NA 0 J protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s L NA 0 J protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s N NA 0 M protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q7s O NA 0 M protein NA spike protein s1 ANTIVIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Guttler, T., Aksu, M., Gorlich, D. 2.7 X-RAY DIFFRACTION 0.283 0.233 False True IGHV1 NA NA None None None None None 8q93 B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/20/23 Crystal structure of the SARS-COV-2 RBD with neutralizing-VHHs Re30H02 and Re21D01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Guttler, T., Rymarenko, O., Gorlich, D. 3.1 X-RAY DIFFRACTION 0.257 0.200 False True IGHV1 NA NA None None None None None 8q93 C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/20/23 Crystal structure of the SARS-COV-2 RBD with neutralizing-VHHs Re30H02 and Re21D01 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Guttler, T., Rymarenko, O., Gorlich, D. 3.1 X-RAY DIFFRACTION 0.257 0.200 False True IGHV1 NA NA None None None None None 8q94 B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/20/23 Crystal structure of The SARS-COV-2 BA.2.75 RBD with neutralizing-VHHs Re32D03 and Ma3B12 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Guttler, T., Gorlich, D. 2.5 X-RAY DIFFRACTION 0.277 0.220 False True IGHV1 NA NA None None None None None 8q94 C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/20/23 Crystal structure of The SARS-COV-2 BA.2.75 RBD with neutralizing-VHHs Re32D03 and Ma3B12 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Guttler, T., Gorlich, D. 2.5 X-RAY DIFFRACTION 0.277 0.220 False True IGHV1 NA NA None None None None None 8q95 B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 BA.1 RBD with neutralizing-VHHs Ma16B06 and Ma3F05 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Rymarenko, O., Guttler, T., Gorlich, D. 1.6 X-RAY DIFFRACTION 0.206 0.176 False True IGHV1 NA NA None None None None None 8q95 C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/20/23 Crystal structure of the SARS-CoV-2 BA.1 RBD with neutralizing-VHHs Ma16B06 and Ma3F05 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Rymarenko, O., Guttler, T., Gorlich, D. 1.6 X-RAY DIFFRACTION 0.206 0.176 False True unknown unknown unknown None None None None None 8tlm A B 0 C protein NA c-c chemokine receptor type 8, green fluorescent proteinfusion STRUCTURAL PROTEIN 12/20/23 Structure of a class A GPCR/Fab complex Aequorea victoria; Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens, aequorea victoria Sun, D., Johnson, M., Masureel, M. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8u1u E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 12/20/23 Structure of a class A GPCR/agonist complex Homo sapiens; Human adenovirus C serotype 2; Mus musculus mus musculus homo sapiens | homo sapiens Sun, D., Johnson, M., Masureel, M. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ycy D E 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 1-RBD up Spike trimer complexed with three XG005 molecules Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7ycy F G 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 1-RBD up Spike trimer complexed with three XG005 molecules Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7ycy H I 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 1-RBD up Spike trimer complexed with three XG005 molecules Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7ycz D E 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 2-RBD up Spike trimer complexed with three XG005 molecules Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.24 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7ycz F G 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 2-RBD up Spike trimer complexed with three XG005 molecules Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.24 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7ycz H I 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 2-RBD up Spike trimer complexed with three XG005 molecules Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.24 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7yd0 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 1-RBD up spike trimer complexed with two XG005 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.58 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7yd0 F G 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/13/23 SARS-CoV-2 Omicron 1-RBD up spike trimer complexed with two XG005 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.58 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 8d01 H L 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 The domain-swaped dimer of the HIV-1 CD4bs targeting antibody 21N13 Macaca mulatta macaca mulatta macaca mulatta Xian, Y., Wilson, A. 2.46 X-RAY DIFFRACTION 0.229 0.189 False True IGHV4 IGKV1 Kappa None None None None None 8d01 A B 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 The domain-swaped dimer of the HIV-1 CD4bs targeting antibody 21N13 Macaca mulatta macaca mulatta macaca mulatta Xian, Y., Wilson, A. 2.46 X-RAY DIFFRACTION 0.229 0.189 False True IGHV4 IGKV1 Kappa None None None None None 8d4r D E 0 B protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal Structure of Mosaic HIV-1 Envelope (MosM3.2) in Complex with antibodies PGT124 and 35O22 at 3.8 Angstrom Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xian, Y., Wilson, A. 3.81 X-RAY DIFFRACTION 0.296 0.277 False True unknown unknown unknown None None None None None 8d4r H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal Structure of Mosaic HIV-1 Envelope (MosM3.2) in Complex with antibodies PGT124 and 35O22 at 3.8 Angstrom Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xian, Y., Wilson, A. 3.81 X-RAY DIFFRACTION 0.296 0.277 False True IGHV4 unknown unknown None None None None None 8d50 D E 0 B protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal Structure of Mosaic HIV-1 Envelope (MosM3.1) in Complex with antibodies PGT124 and 35O22 at 4.3 Angstrom Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xian, Y., Wilson, A. 4.32 X-RAY DIFFRACTION 0.369 0.323 False True unknown unknown unknown None None None None None 8d50 H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal Structure of Mosaic HIV-1 Envelope (MosM3.1) in Complex with antibodies PGT124 and 35O22 at 4.3 Angstrom Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xian, Y., Wilson, A. 4.32 X-RAY DIFFRACTION 0.369 0.323 False True IGHV4 unknown unknown None None None None None 8f2j A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.245 0.209 False True IGHV3 IGLV3 Lambda None None None None None 8f2j D F 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.245 0.209 False True IGHV3 IGLV3 Lambda None None None None None 8f2j H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.245 0.209 False True IGHV3 IGLV3 Lambda None None None None None 8f2j I J 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.245 0.209 False True IGHV3 IGLV3 Lambda None None None None None 8f2t A B 0 NA NA NA NA IMMUNE SYSTEM 12/13/23 Antibody Fab directed against SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) Homo sapiens homo sapiens homo sapiens Chen, J.C.-H. 2.12 X-RAY DIFFRACTION 0.257 0.203 False True IGHV3 IGKV1 Kappa None None None None None 8f2v D C 0 NA NA NA NA IMMUNE SYSTEM 12/13/23 Antibody Fab directed against SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) Homo sapiens homo sapiens homo sapiens Chen, J.C.-H. 3.5 X-RAY DIFFRACTION 0.289 0.246 False True IGHV1 IGLV3 Lambda None None None None None 8f2v B A 0 NA NA NA NA IMMUNE SYSTEM 12/13/23 Antibody Fab directed against SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) Homo sapiens homo sapiens homo sapiens Chen, J.C.-H. 3.5 X-RAY DIFFRACTION 0.289 0.246 False True IGHV1 IGLV3 Lambda None None None None None 8f2v F E 0 NA NA NA NA IMMUNE SYSTEM 12/13/23 Antibody Fab directed against SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) Homo sapiens homo sapiens homo sapiens Chen, J.C.-H. 3.5 X-RAY DIFFRACTION 0.289 0.246 False True IGHV1 IGLV3 Lambda None None None None None 8f38 D G 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Cryo-EM structure of X6 COBRA (H1N1) hemagglutinin bound to CR6261 Fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8f38 E H 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Cryo-EM structure of X6 COBRA (H1N1) hemagglutinin bound to CR6261 Fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8f38 F I 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Cryo-EM structure of X6 COBRA (H1N1) hemagglutinin bound to CR6261 Fab Homo sapiens; synthetic construct homo sapiens homo sapiens synthetic construct Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8fah H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with SARS-CoV-2 reactive human antibody CR3022 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 4.22 X-RAY DIFFRACTION 0.286 0.246 False True IGHV5 IGKV4 Kappa None None None None None 8k45 D NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, Y., Gao, Y., Yao, H., Xu, W., Yang, H. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8k45 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, Y., Gao, Y., Yao, H., Xu, W., Yang, H. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8k46 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, Y., Gao, Y., Yao, H., Xu, W., Yang, H. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8k46 G NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, Y., Gao, Y., Yao, H., Xu, W., Yang, H. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8k46 I NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, Y., Gao, Y., Yao, H., Xu, W., Yang, H. 3.37 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8k47 I NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses including all major Omicron strains Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lu, Y., Gao, Y., Yao, H., Xu, W., Yang, H. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8r8d E I 0 B protein NA coagulation factor xii BLOOD CLOTTING 12/13/23 Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer) Homo sapiens homo sapiens homo sapiens homo sapiens Drulyte, I. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8r8d H L 0 A protein NA coagulation factor xii BLOOD CLOTTING 12/13/23 Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer) Homo sapiens homo sapiens homo sapiens homo sapiens Drulyte, I. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8smi H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/13/23 Crystal structure of antibody WRAIR-2123 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 3.5 X-RAY DIFFRACTION 0.295 0.242 False True IGHV3 IGKV1 Kappa None None None None None 8sos D NA 0 A protein NA antigen-presenting glycoprotein cd1d IMMUNE SYSTEM 12/13/23 Human CD1d presenting sphingomyelin C24:1 in complex with VHH nanobody 1D17 Homo sapiens; Lama glama lama glama homo sapiens Shahine, A., Rossjohn, J. 2.33 X-RAY DIFFRACTION 0.230 0.209 False True IGHV1 NA NA None None None None None 8sos G NA 0 E protein NA antigen-presenting glycoprotein cd1d IMMUNE SYSTEM 12/13/23 Human CD1d presenting sphingomyelin C24:1 in complex with VHH nanobody 1D17 Homo sapiens; Lama glama lama glama homo sapiens Shahine, A., Rossjohn, J. 2.33 X-RAY DIFFRACTION 0.230 0.209 False True IGHV1 NA NA None None None None None 8ek5 E e 0 A | C protein | peptide NA | NA mhc class i antigen | paired mesoderm homeobox protein 2b peptide ANTITUMOR PROTEIN 12/06/23 Engineered scFv 10LH bound to PHOX2B/HLA-A24:02 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Garfinkle, S.E., Florio, T.J., Sgourakis, N.G. 2.11 X-RAY DIFFRACTION 0.212 0.181 True True unknown unknown unknown None None None None None 8feg F f 0 C | D protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/06/23 Structure of KOR and G protein complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Fay, J.F., Che, T. 2.54 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hws H L 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/06/23 The complex structure of Omicron BA.4 RBD with BD604, S309, and S304 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 He, Q.W., Xu, Z.P., Xie, Y.F. 2.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hws D E 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/06/23 The complex structure of Omicron BA.4 RBD with BD604, S309, and S304 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 He, Q.W., Xu, Z.P., Xie, Y.F. 2.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hws I J 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/06/23 The complex structure of Omicron BA.4 RBD with BD604, S309, and S304 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 He, Q.W., Xu, Z.P., Xie, Y.F. 2.36 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8hwt H L 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/06/23 SARS-CoV-2 Omicron BA.2 RBD complexed with BD-604 and S304 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 He, Q.W., Xie, Y. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hwt D E 0 A protein NA spike protein s2' IMMUNE SYSTEM/VIRAL PROTEIN 12/06/23 SARS-CoV-2 Omicron BA.2 RBD complexed with BD-604 and S304 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 He, Q.W., Xie, Y. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ia7 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 NEUROPEPTIDE 12/06/23 Structural insights into human brain gut peptide cholecystokinin receptors Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j6p S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/06/23 Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Mao, C., Gao, M., Zang, S., Zhu, Y., Ma, X., Zhang, Y. 2.55 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j6q S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/06/23 Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Mao, C., Gao, M., Zang, S., Zhu, Y., Ma, X., Zhang, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j6r S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/06/23 Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Mao, C., Gao, M., Zang, S., Zhu, Y., Ma, X., Zhang, Y. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8q6k H L 0 NA NA NA NA IMMUNE SYSTEM 12/06/23 Human IgD Fab in complex with an orthosteric inhibitor of Phl p 7 Camelidae mixed library; Homo sapiens homo sapiens homo sapiens Davies, A.M., Vester, S.K., McDonnell, J.M. 2.1 X-RAY DIFFRACTION 0.259 0.214 False True IGHV1 IGLV1 Lambda None None None None None 8q6k N NA 0 NA NA NA NA IMMUNE SYSTEM 12/06/23 Human IgD Fab in complex with an orthosteric inhibitor of Phl p 7 Camelidae mixed library; Homo sapiens camelidae mixed library Davies, A.M., Vester, S.K., McDonnell, J.M. 2.1 X-RAY DIFFRACTION 0.259 0.214 False True IGHV1 NA NA None None None None None 8tui H L 0 A protein NA killer cell immunoglobulin-like receptor 2dl3 IMMUNE SYSTEM 12/06/23 Crystal structure of Fab-Lirilumab bound to KIR2DL3 Homo sapiens homo sapiens homo sapiens homo sapiens Lorig-Roach, N., DuBois, R.M. 2.75 X-RAY DIFFRACTION 0.254 0.211 False True IGHV1 IGKV3 Kappa None None None None None 8ucd H L 0 C | A | B protein | protein | protein NA | NA | NA metalloreductase steap1 | metalloreductase steap1 | metalloreductase steap1 membrane protein/immune system 11/22/23 Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Li, F., Bailis, J.M., Zhang, H. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8bk2 H L 0 A protein NA factor h-binding protein PROTEIN BINDING 11/22/23 X-ray structure of meningococcal factor H binding protein variant 2 in complex with a specific and bactericidal human monoclonal antibody 1B1 Homo sapiens; Neisseria meningitidis serogroup B homo sapiens homo sapiens neisseria meningitidis serogroup b Veggi, D., Bottomley, J.M. 2.41 X-RAY DIFFRACTION 0.270 0.204 False True IGHV3 IGKV3 Kappa None None None None None 8bk2 D E 0 B protein NA factor h-binding protein PROTEIN BINDING 11/22/23 X-ray structure of meningococcal factor H binding protein variant 2 in complex with a specific and bactericidal human monoclonal antibody 1B1 Homo sapiens; Neisseria meningitidis serogroup B homo sapiens homo sapiens neisseria meningitidis serogroup b Veggi, D., Bottomley, J.M. 2.41 X-RAY DIFFRACTION 0.270 0.204 False True IGHV3 IGKV3 Kappa None None None None None 8bk2 F G 0 C protein NA factor h-binding protein PROTEIN BINDING 11/22/23 X-ray structure of meningococcal factor H binding protein variant 2 in complex with a specific and bactericidal human monoclonal antibody 1B1 Homo sapiens; Neisseria meningitidis serogroup B homo sapiens homo sapiens neisseria meningitidis serogroup b Veggi, D., Bottomley, J.M. 2.41 X-RAY DIFFRACTION 0.270 0.204 False True IGHV3 IGKV3 Kappa None None None None None 8cr9 A B 0 C protein NA maltose/maltodextrin-binding periplasmic protein,type iiisecretion protein pcrv ANTIMICROBIAL PROTEIN 11/22/23 Cryo-EM structure of PcrV/Fab(30-B8) Homo sapiens; Pseudomonas aeruginosa homo sapiens homo sapiens pseudomonas aeruginosa Yuan, B., Simonis, A., Marlovits, T.C. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8crb A B 0 C protein NA maltose/maltodextrin-binding periplasmic protein,type iiisecretion protein pcrv ANTIMICROBIAL PROTEIN 11/22/23 Cryo-EM structure of PcrV/Fab(11-E5) Homo sapiens; Pseudomonas aeruginosa homo sapiens homo sapiens pseudomonas aeruginosa Yuan, B., Simonis, A., Marlovits, T.C. 4.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV1 Lambda None None None None None 8hnk S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/23 CXCR3-DNGi complex activated by CXCL11 Escherichia coli; Homo sapiens; Oplophorus gracilirostris homo sapiens homo sapiens | homo sapiens Jiao, H.Z., Hu, H.L. 3.01 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hnl S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/23 CXCR3-DNGi complex activated by PS372424 Escherichia coli; Homo sapiens; Oplophorus gracilirostris homo sapiens homo sapiens | homo sapiens Jiao, H.Z., Hu, H.L. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hnm S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/23 CXCR3-DNGi complex activated by VUF11222 Escherichia coli; Homo sapiens; Oplophorus gracilirostris homo sapiens homo sapiens | homo sapiens Jiao, H.Z., Hu, H.L. 2.94 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hnn N NA 0 R protein NA soluble cytochrome b562,c-x-c chemokine receptor type 3,kappa-type opioid receptor SIGNALING PROTEIN 11/29/23 Structure of CXCR3 complexed with antagonist SCH546738 Escherichia coli; Homo sapiens; Lama glama lama glama escherichia coli, homo sapiens Jiao, H.Z., Hu, H.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8j1t H K 0 F protein NA spike protein VIRAL PROTEIN/IMMUNE SYSTEM 11/29/23 Local refined cryo-EM structure of Omicron BA.5 RBD in complex with 8-9D Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Li, R. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j1v H K 0 A protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 11/29/23 Cryo-EM structure of SARS-CoV2 Omicron BA.5 spike in complex with 8-9D Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Li, R. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j1v C D 0 B protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 11/29/23 Cryo-EM structure of SARS-CoV2 Omicron BA.5 spike in complex with 8-9D Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Li, R. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j1v F G 0 E protein NA spike protein s2' VIRAL PROTEIN/IMMUNE SYSTEM 11/29/23 Cryo-EM structure of SARS-CoV2 Omicron BA.5 spike in complex with 8-9D Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Li, R. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8j5j E NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/22/23 The crystal structure of bat coronavirus RsYN04 RBD bound to the antibody S43 Betacoronavirus sp.; Vicugna pacos vicugna pacos betacoronavirus sp. Zhao, R.C., Niu, S., Han, P., Qi, J.X., Gao, G.F., Wang, Q.H. 3 X-RAY DIFFRACTION 0.231 0.227 False True IGHV1 NA NA None None None None None 8k2w N NA 0 R protein NA soluble cytochrome b562,c-x-c chemokine receptor type 3,kappa-type opioid receptor SIGNALING PROTEIN 11/29/23 Structure of CXCR3 complexed with antagonist AMG487 Escherichia coli; Homo sapiens; Lama glama lama glama escherichia coli, homo sapiens Jiao, H.Z., Hu, H.L. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8k2x S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/23 CXCR3-DNGi complex activated by CXCL10 Escherichia coli; Homo sapiens; Oplophorus gracilirostris oplophorus gracilirostris homo sapiens | homo sapiens Jiao, H.Z., Hu, H.L. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8pvb O NA 0 A protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 11/29/23 Structure of GABAAR determined by cryoEM at 100 keV Homo sapiens; Lama glama lama glama homo sapiens McMullan, G., Naydenova, K., Mihaylov, D., Peet, M.J., Wilson, H., Yamashita, K., Dickerson, J.L., Chen, S., Cannone, G., Lee, Y., Hutchings, K.A., Gittins, O., Sobhy, M., Wells, T., El-Gomati, M.M., Dalby, J., Meffert, M., Schulze-Briese, C., Henderson, R., Russo, C.J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8r61 A B 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama homo sapiens homo sapiens Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 IGKV1 Kappa None None None None None 8r61 D E 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama homo sapiens homo sapiens Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 IGKV1 Kappa None None None None None 8r61 G H 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama homo sapiens homo sapiens Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 IGKV1 Kappa None None None None None 8r61 J K 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama homo sapiens homo sapiens Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 IGKV1 Kappa None None None None None 8r61 M N 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama homo sapiens homo sapiens Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 IGKV1 Kappa None None None None None 8r61 P Q 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama homo sapiens homo sapiens Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 IGKV1 Kappa None None None None None 8r61 C NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama lama glama Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 NA NA None None None None None 8r61 F NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama lama glama Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 NA NA None None None None None 8r61 I NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama lama glama Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 NA NA None None None None None 8r61 L NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama lama glama Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 NA NA None None None None None 8r61 O NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama lama glama Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 NA NA None None None None None 8r61 R NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of IgE delta epsilon 3-4 in complex with a kappa binding nanobody Homo sapiens; Lama glama lama glama Andersen, G.R., Gandini, R. 3.1 X-RAY DIFFRACTION 0.275 0.232 False True IGHV1 NA NA None None None None None 8skj A NA 0 E peptide NA v5 epitope tag peptide BIOSYNTHETIC PROTEIN 11/22/23 Crystal structure of a Nanobody bound to the V5 peptide. Camelidae; SYNTHETIC CONSTRUCT camelidae simian virus 12 Zaghal, M., Matte, K., Venes, A., Patel, S., Laroche, G., Sarvan, S., Joshi, M., Couture, J.F., Giguere, P.M. 2.01 X-RAY DIFFRACTION 0.236 0.189 False True IGHV3 NA NA None None None None None 8skj B NA 0 C peptide NA v5 epitope tag peptide BIOSYNTHETIC PROTEIN 11/22/23 Crystal structure of a Nanobody bound to the V5 peptide. Camelidae; SYNTHETIC CONSTRUCT camelidae simian virus 12 Zaghal, M., Matte, K., Venes, A., Patel, S., Laroche, G., Sarvan, S., Joshi, M., Couture, J.F., Giguere, P.M. 2.01 X-RAY DIFFRACTION 0.236 0.189 False True IGHV3 NA NA None None None None None 8skj D NA 0 F peptide NA v5 epitope tag peptide BIOSYNTHETIC PROTEIN 11/22/23 Crystal structure of a Nanobody bound to the V5 peptide. Camelidae; SYNTHETIC CONSTRUCT camelidae simian virus 12 Zaghal, M., Matte, K., Venes, A., Patel, S., Laroche, G., Sarvan, S., Joshi, M., Couture, J.F., Giguere, P.M. 2.01 X-RAY DIFFRACTION 0.236 0.189 False True IGHV3 NA NA None None None None None 8skj G NA 0 H peptide NA v5 epitope tag peptide BIOSYNTHETIC PROTEIN 11/22/23 Crystal structure of a Nanobody bound to the V5 peptide. Camelidae; SYNTHETIC CONSTRUCT camelidae simian virus 12 Zaghal, M., Matte, K., Venes, A., Patel, S., Laroche, G., Sarvan, S., Joshi, M., Couture, J.F., Giguere, P.M. 2.01 X-RAY DIFFRACTION 0.236 0.189 False True IGHV3 NA NA None None None None None 8t58 C B 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered FNQIKG elbow region Homo sapiens homo sapiens homo sapiens Filippova, E.V., Kossiakoff, A.A. 2.23 X-RAY DIFFRACTION 0.225 0.182 False True IGHV3 IGKV1 Kappa None None None None None 8t58 F E 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered FNQIKG elbow region Homo sapiens homo sapiens homo sapiens Filippova, E.V., Kossiakoff, A.A. 2.23 X-RAY DIFFRACTION 0.225 0.182 False True IGHV3 IGKV1 Kappa None None None None None 8t58 A NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered FNQIKG elbow region Homo sapiens homo sapiens Filippova, E.V., Kossiakoff, A.A. 2.23 X-RAY DIFFRACTION 0.225 0.182 False True IGHV1 NA NA None None None None None 8t58 D NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered FNQIKG elbow region Homo sapiens homo sapiens Filippova, E.V., Kossiakoff, A.A. 2.23 X-RAY DIFFRACTION 0.225 0.182 False True IGHV1 NA NA None None None None None 8t6i H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered Crystal Kappa region Homo sapiens homo sapiens homo sapiens Filippova, E.V., Thompson, I., Kossiakoff, A.A. 2.55 X-RAY DIFFRACTION 0.255 0.194 False True IGHV3 IGKV1 Kappa None None None None None 8t6i A NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered Crystal Kappa region Homo sapiens homo sapiens Filippova, E.V., Thompson, I., Kossiakoff, A.A. 2.55 X-RAY DIFFRACTION 0.255 0.194 False True IGHV1 NA NA None None None None None 8t7f C G 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the S1 variant of Fab F1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.306 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8t7f A B 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the S1 variant of Fab F1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.306 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8t7f D E 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the S1 variant of Fab F1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.306 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8t7f F H 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the S1 variant of Fab F1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.306 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8t7f I J 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the S1 variant of Fab F1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.306 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8t7f K L 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the S1 variant of Fab F1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3.5 X-RAY DIFFRACTION 0.306 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8t7g A B 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the CK variant of Fab F1 (FabC-F1) Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 2 X-RAY DIFFRACTION 0.228 0.194 False True IGHV3 IGKV1 Kappa None None None None None 8t7i A B 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 Structure of the S1CE variant of Fab F1 (FabS1CE-F1) Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Enderle, L., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 2.6 X-RAY DIFFRACTION 0.257 0.201 False True IGHV3 IGKV1 Kappa None None None None None 8t8i H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions Homo sapiens homo sapiens homo sapiens Filippova, E.V., Thompson, I., Kossiakoff, A.A. 2.52 X-RAY DIFFRACTION 0.243 0.191 False True IGHV3 IGKV1 Kappa None None None None None 8t8i A NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions Homo sapiens homo sapiens Filippova, E.V., Thompson, I., Kossiakoff, A.A. 2.52 X-RAY DIFFRACTION 0.243 0.191 False True IGHV1 NA NA None None None None None 8t9y H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions Homo sapiens homo sapiens homo sapiens Filippova, E.V., Thompson, I., Kossiakoff, A.A. 2.52 X-RAY DIFFRACTION 0.285 0.214 False True IGHV3 IGKV1 Kappa None None None None None 8t9y A NA 0 NA NA NA NA IMMUNE SYSTEM 11/29/23 Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions Homo sapiens homo sapiens Filippova, E.V., Thompson, I., Kossiakoff, A.A. 2.52 X-RAY DIFFRACTION 0.285 0.214 False True IGHV1 NA NA None None None None None 8t9z H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 11/22/23 Structural of M8C10 Fab in complex human metapneumovirus fusion protein Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Su, H.P., Eddins, M.J., Shipman, J.M., Kostas, J., Reid, J.C. 2.995 X-RAY DIFFRACTION 0.280 0.244 False True IGHV3 IGKV1 Kappa None None None None None 8ti4 H L 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface Homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., van Dyk, N., Mazor, Y. 2.1 X-RAY DIFFRACTION 0.251 0.201 False True IGHV3 IGKV1 Kappa None None None None None 8tjf H L 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface Homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., van Dyk, N., Mazor, Y., Chiang, C. 2.3 X-RAY DIFFRACTION 0.251 0.208 False True IGHV3 IGKV1 Kappa None None None None None 8tjf B A 0 NA NA NA NA IMMUNE SYSTEM 11/22/23 monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface Homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., van Dyk, N., Mazor, Y., Chiang, C. 2.3 X-RAY DIFFRACTION 0.251 0.208 False True IGHV3 IGKV1 Kappa None None None None None 8trs A G 0 D protein NA ephrin type-a receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 11/22/23 Structure of the EphA2 CRD bound to FabS1CE_C1, trigonal form Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 1.9 X-RAY DIFFRACTION 0.214 0.180 False True IGHV3 IGKV1 Kappa None None None None None 8trt A G 0 E protein NA ephrin type-a receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 11/22/23 Structure of the EphA2 CRD bound to FabS1CE_C1, monoclinic form Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3 X-RAY DIFFRACTION 0.244 0.194 False True IGHV3 IGKV1 Kappa None None None None None 8trt B C 0 D protein NA ephrin type-a receptor 2 SIGNALING PROTEIN/IMMUNE SYSTEM 11/22/23 Structure of the EphA2 CRD bound to FabS1CE_C1, monoclinic form Homo sapiens homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L., Adams, J.J., Sicheri, F., Sidhu, S.S. 3 X-RAY DIFFRACTION 0.244 0.194 False True IGHV3 IGKV1 Kappa None None None None None 8ts5 A G 0 NA NA NA NA SIGNALING PROTEIN/IMMUNE SYSTEM 11/22/23 Structure of the apo FabS1C_C1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L.L., Adams, J.J., Sicheri, F., Sidhu, S.S. 2.1 X-RAY DIFFRACTION 0.264 0.220 False True IGHV3 IGKV1 Kappa None None None None None 8ts5 B C 0 NA NA NA NA SIGNALING PROTEIN/IMMUNE SYSTEM 11/22/23 Structure of the apo FabS1C_C1 Homo sapiens homo sapiens homo sapiens Singer, A.U., Bruce, H.A., Blazer, L.L., Adams, J.J., Sicheri, F., Sidhu, S.S. 2.1 X-RAY DIFFRACTION 0.264 0.220 False True IGHV3 IGKV1 Kappa None None None None None 8w87 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/22/23 Cryo-EM structure of the METH-TAAR1 complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, H., Zheng, Y., Wang, Y., Wang, Y., He, X., Xu, P., Huang, S., Yuan, Q., Zhang, X., Wang, S., Xu, H.E., Xu, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8w88 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/22/23 Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, H., Zheng, Y., Wang, Y., Wang, Y., He, X., Xu, P., Huang, S., Yuan, Q., Zhang, X., Wang, S., Xu, H.E., Xu, F. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8w89 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/22/23 Cryo-EM structure of the PEA-bound TAAR1-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, H., Zheng, Y., Wang, Y., Wang, Y., He, X., Xu, P., Huang, S., Yuan, Q., Zhang, X., Wang, S., Xu, H.E., Xu, F. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8w8a N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/22/23 Cryo-EM structure of the RO5256390-TAAR1 complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, H., Zheng, Y., Wang, Y., Wang, Y., He, X., Xu, P., Huang, S., Yuan, Q., Zhang, X., Wang, S., Xu, H.E., Xu, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8w8b E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/22/23 Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Liu, H., Zheng, Y., Wang, Y., Wang, Y., He, X., Xu, P., Huang, S., Yuan, Q., Zhang, X., Wang, S., Xu, H.E., Xu, F. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wpu E e 0 G | C protein | protein NA | NA g subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/22/23 Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein Homo sapiens; Rattus norvegicus rattus norvegicus homo sapiens | homo sapiens Ling, S.L., Meng, X.Y., Tian, C.L. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8x0t H L 0 A protein NA frizzled-8 SIGNALING PROTEIN/IMMUNE SYSTEM 11/22/23 Frizzled8 CRD in complex with pF8_AC3 Fab Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Li, N., Ge, Q. 2.5 X-RAY DIFFRACTION 0.290 0.238 False True IGHV3 IGLV3 Lambda None None None None None 8u26 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/15/23 Gaussian Mixture Models based single particle refinement - GPCR (Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 from EMPIAR-10786) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Chen, M., Pintilie, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8u2c D C 0 B protein NA broad substrate specificity atp-binding cassettetransporter abcg2 MEMBRANE PROTEIN 11/15/23 Gaussian mixture model based single particle refinement - ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chen, M., Pintilie, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8u2c F E 0 A protein NA broad substrate specificity atp-binding cassettetransporter abcg2 MEMBRANE PROTEIN 11/15/23 Gaussian mixture model based single particle refinement - ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Chen, M., Pintilie, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8u2c I NA 0 NA NA NA NA MEMBRANE PROTEIN 11/15/23 Gaussian mixture model based single particle refinement - ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374) Homo sapiens; Mus musculus homo sapiens Chen, M., Pintilie, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 NA NA None None None None None 8u2c NA K 0 NA NA NA NA MEMBRANE PROTEIN 11/15/23 Gaussian mixture model based single particle refinement - ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374) Homo sapiens; Mus musculus homo sapiens Chen, M., Pintilie, G. 2.5 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 8u2c J NA 0 NA NA NA NA MEMBRANE PROTEIN 11/15/23 Gaussian mixture model based single particle refinement - ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374) Homo sapiens; Mus musculus homo sapiens Chen, M., Pintilie, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 NA NA None None None None None 8u2c NA L 0 NA NA NA NA MEMBRANE PROTEIN 11/15/23 Gaussian mixture model based single particle refinement - ABC transporter (inhibitor-bound ABCG2 from EMPIAR-10374) Homo sapiens; Mus musculus homo sapiens Chen, M., Pintilie, G. 2.5 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 8udg H L 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/15/23 S1V2-72 Fab bound to EHA2 from influenza B/Malaysia/2506/2004 Homo sapiens; Influenza B virus (B/Malaysia/2506/2004) homo sapiens homo sapiens influenza b virus (b/malaysia/2506/2004) Finney, J., Kong, S., Walsh Jr, R.M., Harrison, S.C., Kelsoe, G. 4.98 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8udg M N 0 B | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/15/23 S1V2-72 Fab bound to EHA2 from influenza B/Malaysia/2506/2004 Homo sapiens; Influenza B virus (B/Malaysia/2506/2004) homo sapiens homo sapiens influenza b virus (b/malaysia/2506/2004) | influenza b virus (b/malaysia/2506/2004) Finney, J., Kong, S., Walsh Jr, R.M., Harrison, S.C., Kelsoe, G. 4.98 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8f4p D NA 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/15/23 SARS-CoV-2 spike protein trimer (down conformation) bound with a nanobody Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Laughlin, Z.T., Patel, A., Ortlund, E.A. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8heg D NA 0 C | B protein | protein NA | NA vp3 of capsid protein | vp2 of capsid protein VIRUS 11/15/23 Pentamer of FMDV (A/TUR/14/98) in complex with M3F Foot-and-mouth disease virus; Lama glama lama glama foot-and-mouth disease virus | foot-and-mouth disease virus Li, H.Z., Dong, H., Liu, P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ix3 H L 0 G protein NA ba.4/5 variant spike protein VIRAL PROTEIN/IMMUNE SYSTEM 11/15/23 Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Z., Zheng, Q., Li, S. 3.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8jlj S s 0 A | B protein | protein NA | NA mgs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/15/23 T1AM-bound mTAAR1-Gs protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, Z., Guo, L.L., Zhao, C., Shen, S.Y., Sun, J.P., Shao, Z.H. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jlk S s 0 A | B protein | protein NA | NA mgs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/15/23 Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, Z., Guo, L.L., Zhao, C., Shen, S.Y., Sun, J.P., Shao, Z.H. 3.22 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jln S s 0 A | B | Y protein | protein | protein NA | NA | NA mgs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/15/23 T1AM-bound hTAAR1-Gs protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Xu, Z., Guo, L.L., Zhao, C., Shen, S.Y., Sun, J.P., Shao, Z.H. 3.24 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jlq S s 0 A | B | Y protein | protein | protein NA | NA | NA mgs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/15/23 Fenoldopam-bound hTAAR1-Gs protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Xu, Z., Guo, L.L., Zhao, C., Shen, S.Y., Sun, J.P., Shao, Z.H. 2.84 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jlr S s 0 A | B protein | protein NA | NA mgs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/15/23 A77636-bound hTAAR1-Gs protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, Z., Guo, L.L., Zhao, C., Shen, S.Y., Sun, J.P., Shao, Z.H. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jso S s 0 A | B protein | protein NA | NA mgs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/15/23 AMPH-bound hTAAR1-Gs protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, Z., Guo, L.L., Zhao, C., Shen, S.Y., Sun, J.P., Shao, Z.H. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jsp E e 0 A | B | G protein | protein | peptide NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 11/15/23 Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Xu, Z., Guo, L.L., Zhao, C., Shen, S.Y., Sun, J.P., Shao, Z.H. 3.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8wsq A B 0 F protein NA fusion glycoprotein f0 ANTIVIRAL PROTEIN/VIRAL PROTEIN 11/15/23 A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein. Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus Xu, S.Y., Chai, Y. 2.9 X-RAY DIFFRACTION 0.280 0.247 False True IGHV3 IGLV1 Lambda None None None None None 8tfn H L 0 B protein NA trbv6-5 IMMUNE SYSTEM 11/08/23 Structure of anti-TCRvbeta6-5 antibody in complex with the cognate TCR Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Katragadda, M., Servatalab, R., Wirth, J. 2.54 X-RAY DIFFRACTION 0.294 0.245 False True IGHV1 IGKV1 Kappa None None None None None 8w83 A B 0 D | C protein | protein NA | NA mhc class ii hla-dq-beta-1 - alpha1 gliadin peptidechimeric protein | hla class ii histocompatibility antigen, dq alpha 1 chain IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.818 X-RAY DIFFRACTION 0.321 0.278 False True IGHV3 IGKV1 Kappa None None None None None 8w83 E F 0 H | G protein | protein NA | NA mhc class ii hla-dq-beta-1 - alpha1 gliadin peptidechimeric protein | hla class ii histocompatibility antigen, dq alpha 1 chain IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.818 X-RAY DIFFRACTION 0.321 0.278 False True IGHV3 IGKV1 Kappa None None None None None 8w83 I J 0 L | K protein | protein NA | NA mhc class ii hla-dq-beta-1 - alpha1 gliadin peptidechimeric protein | hla class ii histocompatibility antigen, dq alpha 1 chain IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.818 X-RAY DIFFRACTION 0.321 0.278 False True IGHV3 IGKV1 Kappa None None None None None 8w83 M N 0 P | O protein | protein NA | NA mhc class ii hla-dq-beta-1 - alpha1 gliadin peptidechimeric protein | hla class ii histocompatibility antigen, dq alpha 1 chain IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.818 X-RAY DIFFRACTION 0.321 0.278 False True IGHV3 IGKV1 Kappa None None None None None 8w85 A B 0 C | D protein | protein NA | NA hla class ii histocompatibility antigen, dq alpha 1 chain | mhc class ii hla-dq-beta-1 - gamma2 gliadin peptidechimeric protein IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-gamma2 gliadin peptide in complex with DQN0385AE01 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.769 X-RAY DIFFRACTION 0.300 0.253 False True IGHV3 IGKV1 Kappa None None None None None 8w85 E F 0 G | H protein | protein NA | NA hla class ii histocompatibility antigen, dq alpha 1 chain | mhc class ii hla-dq-beta-1 - gamma2 gliadin peptidechimeric protein IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-gamma2 gliadin peptide in complex with DQN0385AE01 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.769 X-RAY DIFFRACTION 0.300 0.253 False True IGHV3 IGKV1 Kappa None None None None None 8w86 A B 0 C | D protein | protein NA | NA hla class ii histocompatibility antigen, dq alpha 1 chain | mhc class ii hla-dq-beta-1 - b/c hordein peptide chimericprotein IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-B/C hordein peptide in complex with DQN0385AE02 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.236 X-RAY DIFFRACTION 0.280 0.241 False True IGHV3 IGKV1 Kappa None None None None None 8w86 E F 0 G | H protein | protein NA | NA hla class ii histocompatibility antigen, dq alpha 1 chain | mhc class ii hla-dq-beta-1 - b/c hordein peptide chimericprotein IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-B/C hordein peptide in complex with DQN0385AE02 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.236 X-RAY DIFFRACTION 0.280 0.241 False True IGHV3 IGKV1 Kappa None None None None None 7zox B NA 0 A protein NA nuclear pore complex protein nup93 NUCLEAR PROTEIN 11/08/23 Nup93 in complex with 5-Nup93 inhibitory NB and 15-Nup93 tracking NB Vicugna pacos; Xenopus laevis vicugna pacos xenopus laevis Fu, Z., Guttler, T., Colom, M.S. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7zox C NA 0 A protein NA nuclear pore complex protein nup93 NUCLEAR PROTEIN 11/08/23 Nup93 in complex with 5-Nup93 inhibitory NB and 15-Nup93 tracking NB Vicugna pacos; Xenopus laevis vicugna pacos xenopus laevis Fu, Z., Guttler, T., Colom, M.S. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8bg1 A B 0 C protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV Homo sapiens homo sapiens homo sapiens homo sapiens Hansen, G., Ssebyatika, G.L., Krey, T. 2.88 X-RAY DIFFRACTION 0.244 0.202 True True IGHV3 IGKV2 Kappa None None None None None 8bg1 D E 0 F protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV Homo sapiens homo sapiens homo sapiens homo sapiens Hansen, G., Ssebyatika, G.L., Krey, T. 2.88 X-RAY DIFFRACTION 0.244 0.202 True True IGHV3 IGKV2 Kappa None None None None None 8bg1 G H 0 I protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV Homo sapiens homo sapiens homo sapiens homo sapiens Hansen, G., Ssebyatika, G.L., Krey, T. 2.88 X-RAY DIFFRACTION 0.244 0.202 True True IGHV3 IGKV2 Kappa None None None None None 8bg1 J K 0 L protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV Homo sapiens homo sapiens homo sapiens homo sapiens Hansen, G., Ssebyatika, G.L., Krey, T. 2.88 X-RAY DIFFRACTION 0.244 0.202 True True IGHV3 IGKV2 Kappa None None None None None 8bg2 A a 0 B protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1580 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 2.1 X-RAY DIFFRACTION 0.227 0.189 True True unknown unknown unknown None None None None None 8bg2 C c 0 D protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1580 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 2.1 X-RAY DIFFRACTION 0.227 0.189 True True unknown unknown unknown None None None None None 8bg3 A a 0 B protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1610 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 1.9 X-RAY DIFFRACTION 0.214 0.185 True True unknown unknown unknown None None None None None 8bg3 C c 0 D protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1610 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 1.9 X-RAY DIFFRACTION 0.214 0.185 True True unknown unknown unknown None None None None None 8bg4 A a 0 B protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1611 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 1.6 X-RAY DIFFRACTION 0.208 0.195 True True unknown unknown unknown None None None None None 8bg4 C c 0 D protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1611 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 1.6 X-RAY DIFFRACTION 0.208 0.195 True True unknown unknown unknown None None None None None 8bg5 A a 0 B protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1631 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 2.05 X-RAY DIFFRACTION 0.217 0.196 True True unknown unknown unknown None None None None None 8bg5 C c 0 D protein NA spike protein s1 PROTEIN BINDING 11/08/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1631 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 2.05 X-RAY DIFFRACTION 0.217 0.196 True True unknown unknown unknown None None None None None 8bg6 A B 0 E protein NA spike glycoprotein PROTEIN BINDING 11/08/23 SARS-CoV-2 S protein in complex with pT1644 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Stroeh, L., Hansen, G., Vollmer, B., Krey, T., Benecke, T., Gruenewald, K. 4.11 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8bg8 H L 0 A protein NA spike glycoprotein PROTEIN BINDING 11/08/23 SARS-CoV-2 S protein in complex with pT1696 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Benecke, T., Vollmer, B., Gruenewald, K., Krey, T. 3.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ez3 H L 0 A protein NA neuraminidase Hydrolase/Immune System 11/08/23 Structure of 3A10 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase Homo sapiens; Influenza A virus (A/Moscow/10/1999(H3N2)) homo sapiens homo sapiens influenza a virus (a/moscow/10/1999(h3n2)) Mou, Z., Lei, R., Wu, N.C., Dai, X. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8ez7 H L 0 A protein NA neuraminidase Hydrolase/Immune System 11/08/23 Structure of 1F04 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase Homo sapiens; Influenza A virus (A/Moscow/10/1999(H3N2)) homo sapiens homo sapiens influenza a virus (a/moscow/10/1999(h3n2)) Mou, Z., Lei, R., Wu, N.C., Dai, X. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8ez8 H L 0 A protein NA neuraminidase Hydrolase/Immune System 11/08/23 Structure of 3C08 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase Homo sapiens; Influenza A virus (A/Moscow/10/1999(H3N2)) homo sapiens homo sapiens influenza a virus (a/moscow/10/1999(h3n2)) Mou, Z., Lei, R., Wu, N.C., Dai, X. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8g6u C D 0 B protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.16 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8g6u M N 0 A protein NA crf01_ae t/f100 hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8g6u G H 0 F protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.16 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8g6u O P 0 E protein NA crf01_ae t/f100 hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8g6u K L 0 J protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.16 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8g6u Q R 0 I protein NA crf01_ae t/f100 hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8hes H L 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/08/23 Crystal structure of SARS-CoV-2 RBD and NIV-10 complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Taminishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Someya, T., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 2.2 X-RAY DIFFRACTION 0.241 0.196 False True IGHV3 IGLV2 Lambda None None None None None 8jis N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 11/08/23 Cryo-EM structure of the GLP-1R/GCGR dual agonist peptide15-bound human GLP-1R-Gs complex Bos taurus; Escherichia coli; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Yang, L., Zhou, Q.T., Dai, A.T., Zhao, F.H., Chang, R.L., Ying, T.L., Wu, B.L., Yang, D.H., Wang, M.W., Cong, Z.T. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8kgz A a 0 NA NA NA NA IMMUNE SYSTEM 11/08/23 Crystal structure of single-chain Fv antibody against antigen peptide from SARS-CoV2 S-spike protein Escherichia coli (strain K12); Ovis aries escherichia coli (strain k12), ovis aries Ma, Q.Q., Zhang, B.L., Cheng, X.Y., Huang, Y.Q., Su, Z.D. 2.21 X-RAY DIFFRACTION 0.321 0.269 True True unknown unknown unknown None None None None None 8kgz B b 0 NA NA NA NA IMMUNE SYSTEM 11/08/23 Crystal structure of single-chain Fv antibody against antigen peptide from SARS-CoV2 S-spike protein Escherichia coli (strain K12); Ovis aries escherichia coli (strain k12), ovis aries Ma, Q.Q., Zhang, B.L., Cheng, X.Y., Huang, Y.Q., Su, Z.D. 2.21 X-RAY DIFFRACTION 0.321 0.269 True True unknown unknown unknown None None None None None 8opr B NA 0 A protein NA s-layer protein ea1 STRUCTURAL PROTEIN 11/08/23 Structure of the EA1 surface layer of Bacillus anthracis Bacillus anthracis; Lama glama lama glama bacillus anthracis Sogues, A., Remaut, H. 1.811 X-RAY DIFFRACTION 0.243 0.204 False True IGHV1 NA NA None None None None None 8opr C NA 0 A protein NA s-layer protein ea1 STRUCTURAL PROTEIN 11/08/23 Structure of the EA1 surface layer of Bacillus anthracis Bacillus anthracis; Lama glama lama glama bacillus anthracis Sogues, A., Remaut, H. 1.811 X-RAY DIFFRACTION 0.243 0.204 False True IGHV1 NA NA None None None None None 8ttw C D 0 B protein NA bg505 sosip.664 transmembrane protein gp41 VIRAL PROTEIN/INHIBITOR/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pozharski, E., Pazgier, M. 2.96 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8ttw G H 0 F protein NA bg505 sosip.664 transmembrane protein gp41 VIRAL PROTEIN/INHIBITOR/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pozharski, E., Pazgier, M. 2.96 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8ttw K L 0 J protein NA bg505 sosip.664 transmembrane protein gp41 VIRAL PROTEIN/INHIBITOR/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pozharski, E., Pazgier, M. 2.96 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8ttw M N 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/INHIBITOR/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pozharski, E., Pazgier, M. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8ttw O P 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/INHIBITOR/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pozharski, E., Pazgier, M. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8ttw Q R 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN/INHIBITOR/IMMUNE SYSTEM 11/08/23 Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pozharski, E., Pazgier, M. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8w84 A B 0 D | C protein | protein NA | NA mhc class ii hla-dq-beta-1 - alpha2 gliadin peptidechimeric protein | hla class ii histocompatibility antigen, dq alpha 1 chain IMMUNE SYSTEM 11/08/23 HLA-DQ2.5-alpha2 gliadin peptide in complex with DQN0344AE02 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Irie, M., Tsushima, T., Teranishi-Ikawa, Y., Takahashi, N., Ishii, S., Okura, Y., Fukami, T.A., Torizawa, T. 2.105 X-RAY DIFFRACTION 0.325 0.260 False True IGHV3 IGKV1 Kappa None None None None None 8wrb E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/08/23 Lysophosphatidylserine receptor GPR34-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Gong, W., Liu, G., Li, X., Wang, Y., Zhang, X. 2.91 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8be5 C NA 0 A | R protein | protein NA | NA unknown | isoform 2b of gtpase kras SIGNALING PROTEIN 01/08/09 Crystal structure of SOS1-KRasG12V-Nanobody22-Nanobody75 Homo sapiens; Lama glama lama glama homo sapiens Fischer, B., Wohlkonig, A., Steyaert, J. 3.13 X-RAY DIFFRACTION 0.278 0.226 False True IGHV1 NA NA None None None None None 8be5 N NA 0 A protein NA unknown SIGNALING PROTEIN 01/08/09 Crystal structure of SOS1-KRasG12V-Nanobody22-Nanobody75 Homo sapiens; Lama glama lama glama Fischer, B., Wohlkonig, A., Steyaert, J. 3.13 X-RAY DIFFRACTION 0.278 0.226 False True IGHV1 NA NA None None None None None 8evg M m 0 G | H protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 162bp CX3CR1 nucleosome (further classified with better nucleosome end) Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8evg N n 0 C | D protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 162bp CX3CR1 nucleosome (further classified with better nucleosome end) Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.75 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8evh M m 0 G | H protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 CX3CR1 nucleosome and wild type PU.1 complex Escherichia coli; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8evh N n 0 C | D protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 CX3CR1 nucleosome and wild type PU.1 complex Escherichia coli; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8evi M m 0 G | H protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations Escherichia coli; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.64 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8evi N n 0 C | D protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations Escherichia coli; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.64 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8evj M m 0 G | H | F protein | protein | protein NA | NA | NA histone h2a type 2-c | histone h2b type 2-e | histone h4 TRANSCRIPTION/DNA 11/01/23 CX3CR1 nucleosome bound PU.1 and C/EBPa Escherichia coli; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 4.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8evj N n 0 C | D | B protein | protein | protein NA | NA | NA histone h2a type 2-c | histone h2b type 2-e | histone h4 TRANSCRIPTION/DNA 11/01/23 CX3CR1 nucleosome bound PU.1 and C/EBPa Escherichia coli; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 4.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8syp M m 0 G | H protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 Genomic CX3CR1 nucleosome Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8syp N n 0 C | D protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 11/01/23 Genomic CX3CR1 nucleosome Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Tengfei, L., Ruifang, G., Yawen, B. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8be2 N NA 0 S protein NA son of sevenless homolog 1 SIGNALING PROTEIN 11/01/23 Crystal structure of SOS1-Nanobody77 Homo sapiens; Lama glama lama glama homo sapiens Fischer, B., Wohlkonig, A., Steyaert, J. 1.89794 X-RAY DIFFRACTION 0.211 0.181 False True IGHV1 NA NA None None None None None 8bec A a 0 B protein NA spike protein s1 PROTEIN BINDING 11/01/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1375 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 1.7 X-RAY DIFFRACTION 0.207 0.185 True True unknown unknown unknown None None None None None 8bec C c 0 D protein NA spike protein s1 PROTEIN BINDING 11/01/23 Crystal structure of the SARS-CoV-2 S RBD in complex with pT1375 scFV Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Hansen, G., Ssebyatika, G.L., Krey, T. 1.7 X-RAY DIFFRACTION 0.207 0.185 True True unknown unknown unknown None None None None None 8bf0 H L 0 NA NA NA NA IMMUNE SYSTEM 11/01/23 Structure of a Fab portion from TKH2 Mus musculus mus musculus mus musculus Diskin, R., Borenstein-Katz, A. 1.75 X-RAY DIFFRACTION 0.202 0.168 False True IGHV2 IGKV4 Kappa None None None None None 8eyg E NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/01/23 SARS-CoV-2 spike protein complexed with two nanobodies Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Laughlin, Z.T., Patel, A., Ortlund, E.A. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8eyg F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/01/23 SARS-CoV-2 spike protein complexed with two nanobodies Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Laughlin, Z.T., Patel, A., Ortlund, E.A. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8eyh D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/01/23 SARS-CoV-2 spike protein bound with a nanobody Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Laughlin, Z.T., Patel, A., Ortlund, E.A. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8f7z E F 0 L peptide NA hiv-1 env fusion peptide VIRAL PROTEIN 11/01/23 VRC34.01_mm28 bound to fusion peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Olia, A.S., Kwong, P.D. 2.7 X-RAY DIFFRACTION 0.243 0.211 False True IGHV1 IGKV1 Kappa None None None None None 8f7z A B 0 I peptide NA hiv-1 env fusion peptide VIRAL PROTEIN 11/01/23 VRC34.01_mm28 bound to fusion peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Olia, A.S., Kwong, P.D. 2.7 X-RAY DIFFRACTION 0.243 0.211 False True IGHV1 IGKV1 Kappa None None None None None 8f7z C D 0 K peptide NA hiv-1 env fusion peptide VIRAL PROTEIN 11/01/23 VRC34.01_mm28 bound to fusion peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Olia, A.S., Kwong, P.D. 2.7 X-RAY DIFFRACTION 0.243 0.211 False True IGHV1 IGKV1 Kappa None None None None None 8f7z G H 0 M peptide NA hiv-1 env fusion peptide VIRAL PROTEIN 11/01/23 VRC34.01_mm28 bound to fusion peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Olia, A.S., Kwong, P.D. 2.7 X-RAY DIFFRACTION 0.243 0.211 False True IGHV1 IGKV1 Kappa None None None None None 8f95 H L 0 P peptide NA circumsporozoite protein dnd peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein DND peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.45 X-RAY DIFFRACTION 0.234 0.187 False True IGHV3 IGKV1 Kappa None None None None None 8f95 A B 0 C peptide NA circumsporozoite protein dnd peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein DND peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.45 X-RAY DIFFRACTION 0.234 0.187 False True IGHV3 IGKV1 Kappa None None None None None 8f9e H L 0 P peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.95 X-RAY DIFFRACTION 0.241 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8f9e A B 0 C peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.95 X-RAY DIFFRACTION 0.241 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8f9f H L 0 P peptide NA circumsporozoite protein nanp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NANP3 peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.241 0.213 False True IGHV3 IGKV1 Kappa None None None None None 8f9f A B 0 C peptide NA circumsporozoite protein nanp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NANP3 peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.241 0.213 False True IGHV3 IGKV1 Kappa None None None None None 8f9s H L 0 P peptide NA circumsporozoite protein ndn peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NDN peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.228 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8f9s A B 0 C peptide NA circumsporozoite protein ndn peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NDN peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.228 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8f9t A B 0 C peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 1.85 X-RAY DIFFRACTION 0.216 0.172 False True IGHV3 IGKV1 Kappa None None None None None 8f9t H L 0 P peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 1.85 X-RAY DIFFRACTION 0.216 0.172 False True IGHV3 IGKV1 Kappa None None None None None 8f9u A B 0 P peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.7 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 1.7 X-RAY DIFFRACTION 0.230 0.208 False True IGHV3 IGKV1 Kappa None None None None None 8f9v A B 0 M peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.25 X-RAY DIFFRACTION 0.279 0.259 False True IGHV3 IGKV1 Kappa None None None None None 8f9v C D 0 N peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.25 X-RAY DIFFRACTION 0.279 0.259 False True IGHV3 IGKV1 Kappa None None None None None 8f9v E F 0 O peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.25 X-RAY DIFFRACTION 0.279 0.259 False True IGHV3 IGKV1 Kappa None None None None None 8f9v G H 0 P peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.25 X-RAY DIFFRACTION 0.279 0.259 False True IGHV3 IGKV1 Kappa None None None None None 8f9w A B 0 O peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.241 0.202 False True IGHV3 IGKV1 Kappa None None None None None 8f9w C D 0 P peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.241 0.202 False True IGHV3 IGKV1 Kappa None None None None None 8f9w E F 0 Q peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.241 0.202 False True IGHV3 IGKV1 Kappa None None None None None 8f9w G H 0 R peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.241 0.202 False True IGHV3 IGKV1 Kappa None None None None None 8fa6 H L 0 P peptide NA circumsporozoite protein dnd peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein DND peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.6 X-RAY DIFFRACTION 0.241 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8fa6 A B 0 Q peptide NA circumsporozoite protein dnd peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein DND peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.6 X-RAY DIFFRACTION 0.241 0.204 False True IGHV3 IGKV1 Kappa None None None None None 8fa7 H L 0 P peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.11 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 1.8 X-RAY DIFFRACTION 0.198 0.171 False True IGHV3 IGKV1 Kappa None None None None None 8fa8 H L 0 P peptide NA circumsporozoite protein ndn peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.11 Fab in complex with circumsporozoite protein NDN peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Julien, J.P. 1.8 X-RAY DIFFRACTION 0.201 0.177 False True IGHV3 IGKV1 Kappa None None None None None 8fa9 H L 0 P peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.5 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Prieto, K., Julien, J.P. 2.45 X-RAY DIFFRACTION 0.212 0.187 False True IGHV3 IGKV1 Kappa None None None None None 8fan A B 0 P peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.1 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Burn Aschner, C., Thai, E., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.250 0.215 False True IGHV3 IGKV1 Kappa None None None None None 8fan C D 0 Q peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.1 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Burn Aschner, C., Thai, E., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.250 0.215 False True IGHV3 IGKV1 Kappa None None None None None 8fan E F 0 R peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.1 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Burn Aschner, C., Thai, E., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.250 0.215 False True IGHV3 IGKV1 Kappa None None None None None 8fas A B 0 C peptide NA circumsporozoite protein nanp5 peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky230 Fab in complex with circumsporozoite protein NANP5 peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kassardjian, A., Thai, E., Julien, J.P. 1.55 X-RAY DIFFRACTION 0.198 0.165 False True IGHV3 IGKV2 Kappa None None None None None 8fat A B 0 E peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky224 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kassardjian, A., Thai, E., Julien, J.P. 2.95 X-RAY DIFFRACTION 0.274 0.224 False True IGHV3 IGKV2 Kappa None None None None None 8fat C D 0 F peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky224 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kassardjian, A., Thai, E., Julien, J.P. 2.95 X-RAY DIFFRACTION 0.274 0.224 False True IGHV3 IGKV2 Kappa None None None None None 8fb5 A B 0 O peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.11-S100IK Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kang, R.W., Thai, E., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.274 0.248 False True IGHV3 IGKV1 Kappa None None None None None 8fb5 C D 0 I peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.11-S100IK Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kang, R.W., Thai, E., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.274 0.248 False True IGHV3 IGKV1 Kappa None None None None None 8fb5 E F 0 J peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.11-S100IK Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kang, R.W., Thai, E., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.274 0.248 False True IGHV3 IGKV1 Kappa None None None None None 8fb5 G H 0 K peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.11-S100IK Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kang, R.W., Thai, E., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.274 0.248 False True IGHV3 IGKV1 Kappa None None None None None 8fb6 A B 0 P peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Prieto, K., Thai, E., Julien, J.P. 2.15 X-RAY DIFFRACTION 0.236 0.189 False True IGHV3 IGKV1 Kappa None None None None None 8fb7 A B 0 Q peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Prieto, K., Thai, E., Julien, J.P. 1.75 X-RAY DIFFRACTION 0.198 0.163 False True IGHV3 IGKV1 Kappa None None None None None 8fb7 H L 0 P peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Prieto, K., Thai, E., Julien, J.P. 1.75 X-RAY DIFFRACTION 0.198 0.163 False True IGHV3 IGKV1 Kappa None None None None None 8fb8 H L 0 P peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.10-Y100EK Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kang, R.W., Thai, E., Julien, J.P. 1.69 X-RAY DIFFRACTION 0.184 0.160 False True IGHV3 IGKV1 Kappa None None None None None 8fba A B 0 P peptide NA circumsporozoite protein dnd peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky315 Fab in complex with circumsporozoite protein DND peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Burn Aschner, C., Julien, J.P. 1.96 X-RAY DIFFRACTION 0.220 0.178 False True IGHV3 IGKV3 Kappa None None None None None 8fba C D 0 Q peptide NA circumsporozoite protein dnd peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky315 Fab in complex with circumsporozoite protein DND peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Burn Aschner, C., Julien, J.P. 1.96 X-RAY DIFFRACTION 0.220 0.178 False True IGHV3 IGKV3 Kappa None None None None None 8fdc A B 0 P peptide NA circumsporozoite protein kqpa peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky311 Fab in complex with circumsporozoite protein KQPA peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Burn Aschner, C., Julien, J.P. 1.8 X-RAY DIFFRACTION 0.234 0.199 False True IGHV3 IGKV3 Kappa None None None None None 8fdd A B 0 P peptide NA circumsporozoite protein npdp peptide IMMUNE SYSTEM 11/01/23 Crystal structure of Ky15.3 Fab in complex with circumsporozoite protein NPDP peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Burn Aschner, C., Julien, J.P. 1.54 X-RAY DIFFRACTION 0.204 0.175 False True IGHV3 IGKV1 Kappa None None None None None 8g05 E e 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/01/23 Cryo-EM structure of an orphan GPCR-Gi protein signaling complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Zhang, X., Wang, Y.J., Li, X., Liu, G.B., Gong, W.M., Zhang, C. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8h91 C NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/01/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with nanobody N19 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Zhang, Y.T., Li, J., Zhang, J. 3.07 X-RAY DIFFRACTION 0.284 0.212 False True IGHV1 NA NA None None None None None 8h91 D NA 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/01/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with nanobody N19 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Zhang, Y.T., Li, J., Zhang, J. 3.07 X-RAY DIFFRACTION 0.284 0.212 False True IGHV1 NA NA None None None None None 8hbg E NA 0 C protein NA vp3 of capsid protein VIRUS 11/01/23 FMDV (A/TUR/14/98) in complex with M678F Foot-and-mouth disease virus A; Lama glama lama glama foot-and-mouth disease virus a Li, H.Z., Dong, H., Liu, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hbj E NA 0 C protein NA vp3 of capsid protein VIRUS 11/01/23 cocktail of FMDV (A/TUR/14/98) in complex with M678F and M688F Foot-and-mouth disease virus A; Lama glama lama glama foot-and-mouth disease virus a Li, H.Z., Dong, H., Liu, P. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hbj F NA 0 A protein NA vp1 of capsid protein VIRUS 11/01/23 cocktail of FMDV (A/TUR/14/98) in complex with M678F and M688F Foot-and-mouth disease virus A; Lama glama lama glama foot-and-mouth disease virus a Li, H.Z., Dong, H., Liu, P. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8izb N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/01/23 Lysophosphatidylserine receptor GPR174-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Gong, W., Liu, G., Li, X., Zhang, X. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8pq2 H L 0 C protein NA spike protein s2' VIRAL PROTEIN 11/01/23 XBB 1.0 RBD bound to P4J15 (Local) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duhoo, Y., Lau, K. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8sg1 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/01/23 Cryo-EM structure of CMKLR1 signaling complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Zhang, X., Zhang, C. 2.94 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yfc C c 0 A protein NA engineered g-alpha-q MEMBRANE PROTEIN 10/25/23 Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex Homo sapiens; Lama glama; Mus musculus mus musculus homo sapiens Dohyun, I., So, I., Hidetsugu, A. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yfc N NA 0 A | B protein | protein NA | NA engineered g-alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/25/23 Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Dohyun, I., So, I., Hidetsugu, A. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8u4v H L 0 A | B protein | protein NA | NA claudin-4 | heat-labile enterotoxin b chain MEMBRANE PROTEIN 10/25/23 Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody Clostridium perfringens; Homo sapiens; synthetic construct homo sapiens homo sapiens homo sapiens | clostridium perfringens Vecchio, A.J. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8u4v K NA 0 NA NA NA NA MEMBRANE PROTEIN 10/25/23 Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody Clostridium perfringens; Homo sapiens; synthetic construct synthetic construct Vecchio, A.J. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yfd C c 0 A protein NA engineered g-alpha-q MEMBRANE PROTEIN 10/25/23 Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex Homo sapiens; Lama glama; Mus musculus mus musculus homo sapiens Dohyun, I., So, I., Hidetsugu, A. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yfd N NA 0 A | B protein | protein NA | NA engineered g-alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/25/23 Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Dohyun, I., So, I., Hidetsugu, A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7uqc B A 0 C peptide NA hepatocyte cell adhesion molecule IMMUNE SYSTEM 10/25/23 phospho-GlialCAM peptide AA370-389 with Fab MS39p2w174 Homo sapiens homo sapiens homo sapiens homo sapiens Lanz, T.V., Robinson, W.H., Fernandez, D. 2.65 X-RAY DIFFRACTION 0.237 0.176 False True IGHV3 IGKV2 Kappa None None None None None 7uqc H G 0 NA NA NA NA IMMUNE SYSTEM 10/25/23 phospho-GlialCAM peptide AA370-389 with Fab MS39p2w174 Homo sapiens homo sapiens homo sapiens Lanz, T.V., Robinson, W.H., Fernandez, D. 2.65 X-RAY DIFFRACTION 0.237 0.176 False True IGHV3 IGKV2 Kappa None None None None None 7uqc J I 0 NA NA NA NA IMMUNE SYSTEM 10/25/23 phospho-GlialCAM peptide AA370-389 with Fab MS39p2w174 Homo sapiens homo sapiens homo sapiens Lanz, T.V., Robinson, W.H., Fernandez, D. 2.65 X-RAY DIFFRACTION 0.237 0.176 False True IGHV3 IGKV2 Kappa None None None None None 7uqc E D 0 F peptide NA hepatocyte cell adhesion molecule IMMUNE SYSTEM 10/25/23 phospho-GlialCAM peptide AA370-389 with Fab MS39p2w174 Homo sapiens homo sapiens homo sapiens homo sapiens Lanz, T.V., Robinson, W.H., Fernandez, D. 2.65 X-RAY DIFFRACTION 0.237 0.176 False True IGHV3 IGKV2 Kappa None None None None None 8b9v H L 0 A peptide NA alpha-synuclein 110-120 PROTEIN BINDING 10/25/23 Crystal structure of Lu AF82422 in complex with alpha-synuclein 110-120 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Bjerregaard-Andersen, K., Carr, K., Krogh, B.O., Kallunki, P., Tagmose, L., David, L. 2.16 X-RAY DIFFRACTION 0.253 0.197 False True IGHV3 IGKV3 Kappa None None None None None 8cdd E D 0 B protein NA cysteine-rich protective antigen CELL ADHESION 10/25/23 PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 Gallus gallus; Plasmodium falciparum 3D7 gallus gallus gallus gallus plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8cde D C 0 B protein NA cysteine-rich protective antigen CELL ADHESION 10/25/23 PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 Gallus gallus; Plasmodium falciparum 3D7 gallus gallus gallus gallus plasmodium falciparum 3d7 Farrell, B., Higgins, M.K. 3.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8h7i A NA 0 A Hapten WYN quinalphos IMMUNE SYSTEM 10/25/23 Structure of nanobody 11A in complex with quinalphos Camelus bactrianus camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 2.4 X-RAY DIFFRACTION 0.235 0.194 False True IGHV1 NA NA None None None None None 8h7i B NA 0 B Hapten WYN quinalphos IMMUNE SYSTEM 10/25/23 Structure of nanobody 11A in complex with quinalphos Camelus bactrianus camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 2.4 X-RAY DIFFRACTION 0.235 0.194 False True IGHV1 NA NA None None None None None 8h7m A NA 0 A Hapten WYS parathion IMMUNE SYSTEM 10/25/23 Structure of nanobody 11A in complex with parathion Camelus bactrianus camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 1.87 X-RAY DIFFRACTION 0.220 0.184 False True IGHV1 NA NA None None None None None 8h7m B NA 0 B Hapten WYS parathion IMMUNE SYSTEM 10/25/23 Structure of nanobody 11A in complex with parathion Camelus bactrianus camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 1.87 X-RAY DIFFRACTION 0.220 0.184 False True IGHV1 NA NA None None None None None 8h7n A NA 0 A Hapten WYW triazophos IMMUNE SYSTEM 10/25/23 Structure of nanobody 11A in complex with triazophos Camelus bactrianus camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 1.99 X-RAY DIFFRACTION 0.244 0.211 False True IGHV1 NA NA None None None None None 8h7r A NA 0 A Hapten WZ0 coumaphos IMMUNE SYSTEM 10/25/23 Structure of nanobody 11A in complex with coumaphos Camelus bactrianus camelus bactrianus camelus bactrianus Wang, H., Li, J.D., Shen, X., Xu, Z.L., Sun, Y.M. 2 X-RAY DIFFRACTION 0.261 0.224 False True IGHV1 NA NA None None None None None 8h8q H L 0 A peptide NA gln-lys-cys-val-phe-phe-ala-glu-asp-val-gly-ser-asn-cys-gly IMMUNE SYSTEM 10/25/23 Fab-amyloid beta fragment complex at neutral pH Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Kita, A., Irie, K., Irie, Y., Matsushima, Y., Miki, K. 2.5 X-RAY DIFFRACTION 0.275 0.211 False True IGHV1 IGKV8 Kappa None None None None None 8hgl H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/25/23 SARS-CoV-2 spike in complex with neutralizing antibody NIV-11 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8hgl C D 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/25/23 SARS-CoV-2 spike in complex with neutralizing antibody NIV-11 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8hgl F G 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/25/23 SARS-CoV-2 spike in complex with neutralizing antibody NIV-11 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8hgm C D 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/25/23 Structure of SARS-CoV-2 spike RBD in complex with neutralizing antibody NIV-11 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8jtd J N 0 A | D | C protein | protein | protein NA | NA | NA gp120 protein of hiv envelope trimer | gp120 protein of hiv envelope trimer | gp120 protein of hiv envelope trimer VIRAL PROTEIN 10/25/23 BJOX2000.664 trimer in complex with Fab fragment of broadly neutralizing HIV antibody PGT145 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Chatterjee, A., Chen, C., Lee, K., Mangala Prasad, V. 4.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8jtm J N 0 A | D | C protein | protein | protein NA | NA | NA gp120 protein of hiv envelope trimer | gp120 protein of hiv envelope trimer | gp120 protein of hiv envelope trimer VIRAL PROTEIN 10/25/23 CNE55.664 trimer in complex with broadly neutralizing HIV antibody PGT145 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Chatterjee, A., Chen, C., Lee, K., Mangala Prasad, V. 5.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8k4n E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/25/23 Structure of GPR34-Gi complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Wong, T.S., Zeng, Z.C., Xiong, T.T., Gan, S.Y., He, G.D., Du, Y. 2.83 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ci2 F NA 0 A protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ci2 G NA 0 B | C protein | protein NA | NA neuronal acetylcholine receptor subunit alpha-7 | neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ci2 I NA 0 D | E protein | protein NA | NA neuronal acetylcholine receptor subunit alpha-7 | neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tpa H L 0 A | B protein | protein NA | NA hemagglutinin ha1 chain | hemagglutinin ha2 chain VIRAL PROTEIN/Immune System 10/11/23 H1 hemagglutinin (NC99) in complex with medial-junction-targeting Fab 2-2-1G06 Homo sapiens; Influenza A virus (A/New Caledonia/20/1999(H1N1)) homo sapiens homo sapiens influenza a virus (a/newcaledonia/20/1999(h1n1)) | influenza a virus (a/newcaledonia/20/1999(h1n1)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tpa D E 0 C | F protein | protein NA | NA hemagglutinin ha1 chain | hemagglutinin ha2 chain VIRAL PROTEIN/Immune System 10/11/23 H1 hemagglutinin (NC99) in complex with medial-junction-targeting Fab 2-2-1G06 Homo sapiens; Influenza A virus (A/New Caledonia/20/1999(H1N1)) homo sapiens homo sapiens influenza a virus (a/newcaledonia/20/1999(h1n1)) | influenza a virus (a/newcaledonia/20/1999(h1n1)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tpa I J 0 G | K protein | protein NA | NA hemagglutinin ha1 chain | hemagglutinin ha2 chain VIRAL PROTEIN/Immune System 10/11/23 H1 hemagglutinin (NC99) in complex with medial-junction-targeting Fab 2-2-1G06 Homo sapiens; Influenza A virus (A/New Caledonia/20/1999(H1N1)) homo sapiens homo sapiens influenza a virus (a/newcaledonia/20/1999(h1n1)) | influenza a virus (a/newcaledonia/20/1999(h1n1)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8hpt H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNATLING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of C5a-pep bound mouse C5aR1 in complex with Go Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Saha, S., Maharana, J., Yadav, M.K., Sarma, P., Chami, M., Banerjee, R., Shukla, A.K. 3.39 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hqc H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of a GPCR-G protein in complex with a natural peptide agonist Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Saha, S., Maharana, J., Yadav, M.K., Sarma, P., Chami, M., Banerjee, R., Shukla, A.K. 3.89 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8eln C NA 0 A protein NA cftr inhibitory factor IMMUNE SYSTEM 10/18/23 Crystal Structure of Nanobody VHH222 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.229 0.197 False True IGHV1 NA NA None None None None None 8eln D NA 0 B protein NA cftr inhibitory factor IMMUNE SYSTEM 10/18/23 Crystal Structure of Nanobody VHH222 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.229 0.197 False True IGHV1 NA NA None None None None None 8eln G NA 0 E protein NA cftr inhibitory factor IMMUNE SYSTEM 10/18/23 Crystal Structure of Nanobody VHH222 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.229 0.197 False True IGHV1 NA NA None None None None None 8eln H NA 0 F protein NA cftr inhibitory factor IMMUNE SYSTEM 10/18/23 Crystal Structure of Nanobody VHH222 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.229 0.197 False True IGHV1 NA NA None None None None None 8eln K NA 0 I protein NA cftr inhibitory factor IMMUNE SYSTEM 10/18/23 Crystal Structure of Nanobody VHH222 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.229 0.197 False True IGHV1 NA NA None None None None None 8eln L NA 0 J protein NA cftr inhibitory factor IMMUNE SYSTEM 10/18/23 Crystal Structure of Nanobody VHH222 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.229 0.197 False True IGHV1 NA NA None None None None None 8et0 C NA 0 A protein NA prostaglandin g/h synthase 2 MEMBRANE PROTEIN 10/18/23 Crystal Complex of murine Cyclooxygenase-2 with alpaca nanobody F9 Mus musculus; Vicugna pacos vicugna pacos mus musculus Xu, S., Banerjee, S., Uddin, M.J., Goodman, M.C., Marnett, L.J. 2.15 X-RAY DIFFRACTION 0.214 0.181 False True IGHV1 NA NA None None None None None 8et0 D NA 0 B protein NA prostaglandin g/h synthase 2 MEMBRANE PROTEIN 10/18/23 Crystal Complex of murine Cyclooxygenase-2 with alpaca nanobody F9 Mus musculus; Vicugna pacos vicugna pacos mus musculus Xu, S., Banerjee, S., Uddin, M.J., Goodman, M.C., Marnett, L.J. 2.15 X-RAY DIFFRACTION 0.214 0.181 False True IGHV1 NA NA None None None None None 8fzo A B 0 NA NA NA NA IMMUNE SYSTEM 10/18/23 Crystal structure of polyreactive 338E6 mouse Fab Mus musculus mus musculus mus musculus Borowska, M.T., Adams, E.J. 1.83 X-RAY DIFFRACTION 0.220 0.173 False True IGHV5 IGKV6 Kappa None None None None None 8fzp A B 0 NA NA NA NA IMMUNE SYSTEM 10/18/23 Crystal structure of polyreactive 43G10 mouse Fab Mus musculus mus musculus mus musculus Borowska, M.T., Adams, E.J. 1.63 X-RAY DIFFRACTION 0.246 0.224 False True IGHV3 IGKV8 Kappa None None None None None 8g19 H L 0 NA NA NA NA IMMUNE SYSTEM 10/18/23 Crystal structure of monoreactive 4C05 human Fab Homo sapiens homo sapiens homo sapiens Borowska, M.T., Adams, E.J. 1.77 X-RAY DIFFRACTION 0.219 0.187 False True IGHV4 IGLV3 Lambda None None None None None 8g1b A B 0 NA NA NA NA IMMUNE SYSTEM 10/18/23 Crystal structure of polyreactive 2G02 human Fab Homo sapiens homo sapiens homo sapiens Borowska, M.T., Adams, E.J. 1.67 X-RAY DIFFRACTION 0.222 0.194 False True IGHV1 IGKV2 Kappa None None None None None 8g1b C D 0 NA NA NA NA IMMUNE SYSTEM 10/18/23 Crystal structure of polyreactive 2G02 human Fab Homo sapiens homo sapiens homo sapiens Borowska, M.T., Adams, E.J. 1.67 X-RAY DIFFRACTION 0.222 0.194 False True IGHV1 IGKV2 Kappa None None None None None 8g1c A B 0 NA NA NA NA IMMUNE SYSTEM 10/18/23 Crystal structure of polyreactive 3B03 human Fab Homo sapiens homo sapiens homo sapiens Borowska, M.T., Adams, E.J. 1.63 X-RAY DIFFRACTION 0.236 0.202 False True IGHV3 IGKV3 Kappa None None None None None 8g1c C D 0 NA NA NA NA IMMUNE SYSTEM 10/18/23 Crystal structure of polyreactive 3B03 human Fab Homo sapiens homo sapiens homo sapiens Borowska, M.T., Adams, E.J. 1.63 X-RAY DIFFRACTION 0.236 0.202 False True IGHV3 IGKV3 Kappa None None None None None 8g2o H L 0 L carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/18/23 Fab structure - Anti-ApoE-7C11 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Marino, C., Arboleda-Velasquez, J.F. 1.7 X-RAY DIFFRACTION 0.204 0.186 False True IGHV5 IGKV3 Kappa None None None None None 8gje H L 0 A protein NA cza97.12 sosip.664 envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/18/23 HIV-1 Env subtype C CZA97.12 SOSIP.664 in complex with 3BNC117 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Lee, J.H., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8gje G J 0 C protein NA cza97.12 sosip.664 envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/18/23 HIV-1 Env subtype C CZA97.12 SOSIP.664 in complex with 3BNC117 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Lee, J.H., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8gje I K 0 D protein NA cza97.12 sosip.664 envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/18/23 HIV-1 Env subtype C CZA97.12 SOSIP.664 in complex with 3BNC117 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Lee, J.H., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8h5t B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 10/18/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-015 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Yang, J., Lin, S., Lu, G.W. 2 X-RAY DIFFRACTION 0.205 0.171 False True IGHV1 NA NA None None None None None 8h5u B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 10/18/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-021 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Yang, J., Lin, S., Lu, G.W. 2.401 X-RAY DIFFRACTION 0.245 0.225 False True IGHV1 NA NA None None None None None 8h5u D NA 0 C protein NA spike protein s1 VIRAL PROTEIN 10/18/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-021 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Yang, J., Lin, S., Lu, G.W. 2.401 X-RAY DIFFRACTION 0.245 0.225 False True IGHV1 NA NA None None None None None 8i95 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of EP54-C3aR-Go complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 2.88 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8i97 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of Apo-C3aR-Go complex (Glacios) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8i9a H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of EP54-C3aR-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 3.57 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8i9l H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of C3a-C3aR-Go complex (Composite map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 3.18 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8i9s H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of Apo-C3aR-Go complex (Titan) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 3.26 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ia2 H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of C5a bound human C5aR1 in complex with Go (Composite map) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Banerjee, R., Shukla, A.K., Gati, C. 3.21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8itl N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 10/18/23 Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Zhao, F.H., Hang, K.N., Zhou, Q.T., Shao, L.J., Li, H., Li, W.Z., Lin, S., Dai, A.T., Cai, X.Q., Liu, Y.Y., Xu, Y.N., Feng, W.B., Yang, D.H., Wang, M.W. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8itm N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 10/18/23 Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Zhao, F.H., Hang, K.N., Zhou, Q.T., Shao, L.J., Li, H., Li, W.Z., Lin, S., Dai, A.T., Cai, X.Q., Liu, Y.Y., Xu, Y.N., Feng, W.B., Yang, D.H., Wang, M.W. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8j6d H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/18/23 Structure of EP141-C3aR-Go complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jzz H h 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/23 Structure of human C5a-desArg bound human C5aR1 in complex with Go Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C. 3.31 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8kh5 E NA 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/18/23 Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Nie, Y., Qiu, Z., Zheng, S., Chen, S. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8oxv B C 0 A protein NA protein-glutamine gamma-glutamyltransferase e 27 kda non-catalytic chain TRANSFERASE 10/18/23 Transglutaminase 3 zymogen in complex with DH patient-derived Fab DH63-B02 Homo sapiens homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 1.8 X-RAY DIFFRACTION 0.229 0.185 False True IGHV3 IGLV6 Lambda None None None None None 8oxw B C 0 A protein NA protein-glutamine gamma-glutamyltransferase e 27 kda non-catalytic chain TRANSFERASE 10/18/23 Transglutaminase 3 in complex with DH patient-derived Fab DH63-B02 Homo sapiens homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 1.7 X-RAY DIFFRACTION 0.210 0.172 False True IGHV3 IGLV6 Lambda None None None None None 8oxx B C 0 A protein NA protein-glutamine gamma-glutamyltransferase e 27 kda non-catalytic chain TRANSFERASE 10/18/23 Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-B02 Homo sapiens homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 2.5 X-RAY DIFFRACTION 0.222 0.154 False True IGHV3 IGLV6 Lambda None None None None None 8oxy B C 0 A protein NA protein-glutamine gamma-glutamyltransferase e 27 kda non-catalytic chain TRANSFERASE 10/18/23 Transglutaminase 3 without calcium in complex with DH patient-derived Fab DH63-B02 Homo sapiens homo sapiens homo sapiens homo sapiens Heggelund, J.E., Sollid, L.M. 2 X-RAY DIFFRACTION 0.226 0.176 False True IGHV3 IGLV6 Lambda None None None None None 8pnl B NA 0 A protein NA putative triacylglyceride transporter TRANSPORT PROTEIN 10/18/23 Outward-open conformation of a Major Facilitator Superfamily (MFS) transporter MHAS2168, a homologue of Rv1410 from M. tuberculosis, in complex with an alpaca nanobody Mycolicibacterium hassiacum DSM 44199; Vicugna pacos vicugna pacos mycolicibacterium hassiacum dsm 44199 Remm, S., Schoeppe, J., Hutter, C.A.J., Gonda, I., Seeger, M.A. 2.7 X-RAY DIFFRACTION 0.292 0.245 False True IGHV1 NA NA None None None None None 8pnl D NA 0 C protein NA putative triacylglyceride transporter TRANSPORT PROTEIN 10/18/23 Outward-open conformation of a Major Facilitator Superfamily (MFS) transporter MHAS2168, a homologue of Rv1410 from M. tuberculosis, in complex with an alpaca nanobody Mycolicibacterium hassiacum DSM 44199; Vicugna pacos vicugna pacos mycolicibacterium hassiacum dsm 44199 Remm, S., Schoeppe, J., Hutter, C.A.J., Gonda, I., Seeger, M.A. 2.7 X-RAY DIFFRACTION 0.292 0.245 False True IGHV1 NA NA None None None None None 8c9x F NA 0 A protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody Homo sapiens; Vicugna pacos huacaya vicugna pacos huacaya homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c9x G NA 0 B protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody Homo sapiens; Vicugna pacos huacaya vicugna pacos huacaya homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c9x H NA 0 C protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody Homo sapiens; Vicugna pacos huacaya vicugna pacos huacaya homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c9x I NA 0 D protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody Homo sapiens; Vicugna pacos huacaya vicugna pacos huacaya homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c9x J NA 0 E protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody Homo sapiens; Vicugna pacos huacaya vicugna pacos huacaya homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cau F NA 0 A protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cau G NA 0 B protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cau H NA 0 C protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cau I NA 0 D protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cau J NA 0 E protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ce4 F NA 0 A protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ce4 G NA 0 B protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ce4 H NA 0 C protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ce4 I NA 0 D protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ce4 J NA 0 E protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ci1 F NA 0 A protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine Homo sapiens homo sapiens homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ci1 G NA 0 B protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine Homo sapiens homo sapiens homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ci1 H NA 0 C protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine Homo sapiens homo sapiens homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ci1 I NA 0 D protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine Homo sapiens homo sapiens homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8ci1 J NA 0 E protein NA neuronal acetylcholine receptor subunit alpha-7 MEMBRANE PROTEIN 10/11/23 Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine Homo sapiens homo sapiens homo sapiens Prevost, M.S., Barilone, N., Dejean de la Batie, G., Pons, S., Ayme, G., England, P., Gielen, M., Bontems, F., Pehau-Arnaudet, G., Maskos, U., Lafaye, P., Corringer, P.-J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8eq6 H L 0 NA NA NA NA SIGNALING PROTEIN/Immune System 10/11/23 PD1 signaling receptor bound to FAB Complex Homo sapiens; Mus musculus mus musculus mus musculus Bjorkelid, C., Paluch, C., Robertson, N.J. 1.65 X-RAY DIFFRACTION 0.264 0.228 False True IGHV1 IGKV1 Kappa None None None None None 8eqf H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 10/11/23 cryoEM structure of a broadly neutralizing anti-SARS-CoV-2 antibody STI-9167 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Bajic, G. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f5i H L 0 B protein NA specialized acyl carrier protein IMMUNE SYSTEM 10/11/23 SARS-CoV-2 S2 helix epitope scaffold bound by antibody DH1057.1 Homo sapiens; Rhodopseudomonas palustris homo sapiens homo sapiens rhodopseudomonas palustris Kapingidza, A.B., Wrapp, D., Winters, K., Azoitei, M.L. 1.9 X-RAY DIFFRACTION 0.245 0.211 False True IGHV1 IGKV3 Kappa None None None None None 8f5i X Y 0 A protein NA specialized acyl carrier protein IMMUNE SYSTEM 10/11/23 SARS-CoV-2 S2 helix epitope scaffold bound by antibody DH1057.1 Homo sapiens; Rhodopseudomonas palustris homo sapiens homo sapiens rhodopseudomonas palustris Kapingidza, A.B., Wrapp, D., Winters, K., Azoitei, M.L. 1.9 X-RAY DIFFRACTION 0.245 0.211 False True IGHV1 IGKV3 Kappa None None None None None 8fdo A B 0 C protein NA fp15 IMMUNE SYSTEM 10/11/23 SARS-CoV-2 fusion peptide epitope scaffold FP15 bound to DH1058 Escherichia coli; Homo sapiens homo sapiens homo sapiens escherichia coli Kapingidza, A.B., Marston, D.J., Wrapp, D., Winters, K., Azoitei, M.L. 2.2 X-RAY DIFFRACTION 0.229 0.189 False True IGHV3 IGKV1 Kappa None None None None None 8ftt A NA 0 NA NA NA NA PROTEIN BINDING 10/11/23 Crystal structure of a glycosylase specific nanobody synthetic construct synthetic construct Thompson, M.K., Prakash, A. 2.08 X-RAY DIFFRACTION 0.229 0.199 False True IGHV3 NA NA None None None None None 8ftt B NA 0 NA NA NA NA PROTEIN BINDING 10/11/23 Crystal structure of a glycosylase specific nanobody synthetic construct synthetic construct Thompson, M.K., Prakash, A. 2.08 X-RAY DIFFRACTION 0.229 0.199 False True IGHV3 NA NA None None None None None 8ftt C NA 0 NA NA NA NA PROTEIN BINDING 10/11/23 Crystal structure of a glycosylase specific nanobody synthetic construct synthetic construct Thompson, M.K., Prakash, A. 2.08 X-RAY DIFFRACTION 0.229 0.199 False True IGHV3 NA NA None None None None None 8ftt D NA 0 NA NA NA NA PROTEIN BINDING 10/11/23 Crystal structure of a glycosylase specific nanobody synthetic construct synthetic construct Thompson, M.K., Prakash, A. 2.08 X-RAY DIFFRACTION 0.229 0.199 False True IGHV3 NA NA None None None None None 8fwf H L 0 NA NA NA NA IMMUNE SYSTEM 10/11/23 Crystal structure of Apo form Fab235 Mus musculus mus musculus mus musculus Tan, K., Kim, M., Reinherz, E.L. 1.94 X-RAY DIFFRACTION 0.206 0.171 False True IGHV1 IGKV8 Kappa None None None None None 8fxj H L 0 NA NA NA NA IMMUNE SYSTEM 10/11/23 Crystal structure of Fab460 Mus musculus mus musculus mus musculus Tan, K., Kim, M., Reinherz, E.L. 2 X-RAY DIFFRACTION 0.194 0.167 False True IGHV14 IGKV4 Kappa None None None None None 8fym H L 0 P peptide NA ala-ser-leu-trp-asn-trp-phe-asn-ile-thr-asn-trp-leu-trp-tyr-ile-lys-lys-lys IMMUNE SYSTEM 10/11/23 Crystal structure of Fab235 in complex with MPER peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tan, K., Kim, M., Reinherz, E.L. 2.45 X-RAY DIFFRACTION 0.244 0.200 False True IGHV1 IGKV8 Kappa None None None None None 8fym B A 0 C peptide NA ala-ser-leu-trp-asn-trp-phe-asn-ile-thr-asn-trp-leu-trp-tyr-ile-lys-lys-lys IMMUNE SYSTEM 10/11/23 Crystal structure of Fab235 in complex with MPER peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tan, K., Kim, M., Reinherz, E.L. 2.45 X-RAY DIFFRACTION 0.244 0.200 False True IGHV1 IGKV8 Kappa None None None None None 8fym E D 0 F peptide NA ala-ser-leu-trp-asn-trp-phe-asn-ile-thr-asn-trp-leu-trp-tyr-ile-lys-lys-lys IMMUNE SYSTEM 10/11/23 Crystal structure of Fab235 in complex with MPER peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tan, K., Kim, M., Reinherz, E.L. 2.45 X-RAY DIFFRACTION 0.244 0.200 False True IGHV1 IGKV8 Kappa None None None None None 8fym I G 0 J peptide NA ala-ser-leu-trp-asn-trp-phe-asn-ile-thr-asn-trp-leu-trp-tyr-ile-lys-lys-lys IMMUNE SYSTEM 10/11/23 Crystal structure of Fab235 in complex with MPER peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tan, K., Kim, M., Reinherz, E.L. 2.45 X-RAY DIFFRACTION 0.244 0.200 False True IGHV1 IGKV8 Kappa None None None None None 8fz2 H L 0 P peptide NA lys-asp-leu-leu-glu-leu-asp-lys-trp-ala-ser-leu-trp-asn-trp-phe-asp-ile-thr-asn IMMUNE SYSTEM 10/11/23 Crystal structure of Fab460 in complex with MPER peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tan, K., Kim, M., Reinherz, E.L. 3.5 X-RAY DIFFRACTION 0.310 0.262 False True IGHV14 IGKV4 Kappa None None None None None 8grr H L 0 2 protein NA a/wh/cha/09 vp2 VIRUS 10/11/23 Complex of FMDV A/WH/CHA/09 and bovine neutralizing scFv antibody W125 Bos taurus; Foot-and-mouth disease virus A bos taurus bos taurus foot-and-mouth disease virus a He, Y., Kun, L. 3.72 ELECTRON MICROSCOPY NA NA True True IGHV1 IGLV1 Lambda None None None None None 8gsp H L 0 3 | 2 protein | protein NA | NA a/wh/cha/09 vp3 | a/wh/cha/09 vp2 VIRUS 10/11/23 Complex of FMDV A/WH/CHA/09 and bovine neutralizing scFv antibody W2 Bos taurus; Foot-and-mouth disease virus A bos taurus bos taurus foot-and-mouth disease virus a | foot-and-mouth disease virus a He, Y., Li, K. 3.75 ELECTRON MICROSCOPY NA NA True True IGHV1 IGLV1 Lambda None None None None None 8h2g E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/11/23 Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Park, J.H., Ishimoto, N., Park, S.Y. 3.01 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hqe H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/11/23 Cryo-EM structure of the apo-GPR132-Gi Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wang, J.L., Ding, J.H., Sun, J.P., Yu, X. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hqm H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/11/23 Activation mechanism of GPR132 by NPGLY Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wang, J.L., Ding, J.H., Sun, J.P., Yu, X. 2.95 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hqn H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/11/23 Activation mechanism of GPR132 by 9(S)-HODE Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wang, J.L., Ding, J.H., Sun, J.P., Yu, X. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hvi H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/11/23 Activation mechanism of GPR132 by compound NOX-6-7 Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wang, J.L., Ding, J.H., Sun, J.P., Yu, X. 3.04 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8kgk E NA 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(olf) subunit alpha,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/11/23 Cryo-EM structure of the GPR61-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Nie, Y., Qiu, Z., Zheng, S. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8kh4 E NA 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(olf) subunit alpha,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/11/23 Cryo-EM structure of the GPR161-Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Nie, Y., Qiu, Z., Zheng, S., Chen, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8sgj H L 0 A protein NA sodium/calcium exchanger 1 TRANSPORT PROTEIN 10/11/23 Cryo-EM structure of human NCX1 in apo inactivated state Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Xue, J., Jiang, Y. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGLV1 Lambda None None None None None 8sgt H L 0 A protein NA sodium/calcium exchanger 1 TRANSPORT PROTEIN 10/11/23 Cryo-EM structure of human NCX1 in Ca2+ bound, activated state (group II in the presence of 0.5 mM Ca2+) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Xue, J., Jiang, Y. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV1 IGLV1 Lambda None None None None None 8t7h C NA 0 A protein NA metabotropic glutamate receptor 5 SIGNALING PROTEIN 10/11/23 Quis-bound intermediate mGlu5 Homo sapiens; Lama glama lama glama homo sapiens Krishna Kumar, K., Wang, H., Kobilka, B.K. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8t7h D NA 0 B protein NA metabotropic glutamate receptor 5 SIGNALING PROTEIN 10/11/23 Quis-bound intermediate mGlu5 Homo sapiens; Lama glama lama glama homo sapiens Krishna Kumar, K., Wang, H., Kobilka, B.K. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8t8m C NA 0 B protein NA metabotropic glutamate receptor 5 SIGNALING PROTEIN 10/11/23 Quis-bound intermediate mGlu5 Homo sapiens; Lama glama lama glama homo sapiens Krishna Kumar, K., Wang, H., Kobilka, B.K. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8t8m D NA 0 A protein NA metabotropic glutamate receptor 5 SIGNALING PROTEIN 10/11/23 Quis-bound intermediate mGlu5 Homo sapiens; Lama glama lama glama homo sapiens Krishna Kumar, K., Wang, H., Kobilka, B.K. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tao C NA 0 B protein NA metabotropic glutamate receptor 5 SIGNALING PROTEIN 10/11/23 Quis and CDPPB bound active mGlu5 Homo sapiens; Lama glama lama glama homo sapiens Krishna Kumar, K., Wang, H., Kobilka, B.K. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tao D NA 0 A protein NA metabotropic glutamate receptor 5 SIGNALING PROTEIN 10/11/23 Quis and CDPPB bound active mGlu5 Homo sapiens; Lama glama lama glama homo sapiens Krishna Kumar, K., Wang, H., Kobilka, B.K. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8tp2 H L 0 C protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting 1-1-1F05 Homo sapiens homo sapiens homo sapiens homo sapiens Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8tp3 H L 0 C protein NA hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 10/11/23 H1 hemagglutinin (NC99) in complex with RBS-targeting Fab 1-1-1F05 Homo sapiens; Influenza A virus (A/New Caledonia/20/1999(H1N1)) homo sapiens homo sapiens influenza a virus (a/newcaledonia/20/1999(h1n1)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8tp4 H L 0 C protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 1-1-1E04 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8tp5 E F 0 C protein NA hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 10/11/23 H1 hemagglutinin (NC99) in complex with RBS-targeting Fab 1-1-1E04 Homo sapiens; Influenza A virus (A/New Caledonia/20/1999(H1N1)) homo sapiens homo sapiens influenza a virus (a/newcaledonia/20/1999(h1n1)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8tp5 H L 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 10/11/23 H1 hemagglutinin (NC99) in complex with RBS-targeting Fab 1-1-1E04 Homo sapiens; Influenza A virus (A/New Caledonia/20/1999(H1N1)) homo sapiens homo sapiens influenza a virus (a/newcaledonia/20/1999(h1n1)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8tp5 J K 0 G protein NA hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 10/11/23 H1 hemagglutinin (NC99) in complex with RBS-targeting Fab 1-1-1E04 Homo sapiens; Influenza A virus (A/New Caledonia/20/1999(H1N1)) homo sapiens homo sapiens influenza a virus (a/newcaledonia/20/1999(h1n1)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8tp6 H L 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 4-1-1E02 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tp6 C D 0 B protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 4-1-1E02 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tp6 F G 0 E protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with RBS-targeting Fab 4-1-1E02 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tp7 D F 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with Sa-targeting Fab 4-1-1G03 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8tp7 E G 0 B protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with Sa-targeting Fab 4-1-1G03 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8tp7 H L 0 C protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with Sa-targeting Fab 4-1-1G03 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 8tp9 D F 0 B protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with medial-junction-targeting Fab 2-2-1G06 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tp9 E G 0 C protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with medial-junction-targeting Fab 2-2-1G06 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8tp9 H L 0 A protein NA hemagglutinin VIRAL PROTEIN/Immune System 10/11/23 H2 hemagglutinin (A/Singapore/1/1957) in complex with medial-junction-targeting Fab 2-2-1G06 Homo sapiens; Influenza A virus (A/Singapore/1/1957(H2N2)) homo sapiens homo sapiens influenza a virus (a/singapore/1/1957(h2n2)) Yang, Y.R., Han, J., Perrett, H.R., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6x05 K NA 0 A protein NA nucleoporin nup133 STRUCTURAL PROTEIN 12/09/20 Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Vicugna pacos vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 2.1 X-RAY DIFFRACTION 0.219 0.174 False True unknown unknown unknown None None None None None 7ukl X Y 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Cryo-EM structure of Antibody 12-16 in complex with prefusion SARS-CoV-2 Spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7ukl H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Cryo-EM structure of Antibody 12-16 in complex with prefusion SARS-CoV-2 Spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7ukl M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Cryo-EM structure of Antibody 12-16 in complex with prefusion SARS-CoV-2 Spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7ukm X Y 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Cryo-EM structure of Antibody 12-19 in complex with prefusion SARS-CoV-2 Spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7ukm H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Cryo-EM structure of Antibody 12-19 in complex with prefusion SARS-CoV-2 Spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7ukm M N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Cryo-EM structure of Antibody 12-19 in complex with prefusion SARS-CoV-2 Spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Shapiro, L. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8b50 H L 0 H Hapten P0M (2~{S})-2-azanyl-3-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)propanoic acid IMMUNE SYSTEM 10/04/23 Crystal structure of a Fab fragment in complex with L-hydroxycoumarylalanine Mus musculus mus musculus mus musculus mus musculus Meining, W., Eichinger, A., Skerra, A. 1.67 X-RAY DIFFRACTION 0.221 0.191 False True IGHV14 IGKV2 Kappa None None None None None 8e1b A NA 0 NA NA NA NA IMMUNE SYSTEM 10/04/23 Crystal Structure of Nanobody VHH108 Specific for PA14 Cif Vicugna pacos vicugna pacos Simard, A.R., Taher, N.M., Mishra, A.K., Madden, D.R. 1.65 X-RAY DIFFRACTION 0.215 0.212 False True IGHV1 NA NA None None None None None 8e1c A NA 0 NA NA NA NA IMMUNE SYSTEM 10/04/23 Crystal Structure of Nanobody VHH222 Specific for PA14 Cif Vicugna pacos vicugna pacos Simard, A.R., Taher, N.M., Stuut, S.E., Madden, D.R. 1.9 X-RAY DIFFRACTION 0.224 0.212 False True IGHV1 NA NA None None None None None 8e2n B NA 0 NA NA NA NA IMMUNE SYSTEM 10/04/23 Crystal Structure of Nanobody VHH113 Specific for PA14 Cif Vicugna pacos vicugna pacos Simard, A.R., Madden, D.R. 1.1 X-RAY DIFFRACTION 0.213 0.193 False True IGHV1 NA NA None None None None None 8e2n A NA 0 NA NA NA NA IMMUNE SYSTEM 10/04/23 Crystal Structure of Nanobody VHH113 Specific for PA14 Cif Vicugna pacos vicugna pacos Simard, A.R., Madden, D.R. 1.1 X-RAY DIFFRACTION 0.213 0.193 False True IGHV1 NA NA None None None None None 8fq7 A NA 0 NA NA NA NA IMMUNE SYSTEM 10/04/23 Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils Camelus dromedarius camelus dromedarius Abskharon, R., Sawaya, M.R., Cascio, D.C., Eisenberg, D.S. 1.4 X-RAY DIFFRACTION 0.211 0.189 False True IGHV3 NA NA None None None None None 8fxb H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 SARS-CoV-2 XBB.1 spike RBD bound to the human ACE2 ectodomain and the S309 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8fxc H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 SARS-CoV-2 BQ.1.1 spike RBD bound to the human ACE2 ectodomain and the S309 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g0w C NA 0 A protein NA vp1 VIRAL PROTEIN 10/04/23 Crystal structure of human norovirus GII.4 P domain in complex with Nanobody M4 Lama glama; Norovirus lama glama norovirus Hu, L., Salmen, W., Sankaran, B., Prasad, B.V.V. 2.87 X-RAY DIFFRACTION 0.294 0.251 False True IGHV1 NA NA None None None None None 8g0w D NA 0 B protein NA vp1 VIRAL PROTEIN 10/04/23 Crystal structure of human norovirus GII.4 P domain in complex with Nanobody M4 Lama glama; Norovirus lama glama norovirus Hu, L., Salmen, W., Sankaran, B., Prasad, B.V.V. 2.87 X-RAY DIFFRACTION 0.294 0.251 False True IGHV1 NA NA None None None None None 8g0w G NA 0 E protein NA vp1 VIRAL PROTEIN 10/04/23 Crystal structure of human norovirus GII.4 P domain in complex with Nanobody M4 Lama glama; Norovirus lama glama norovirus Hu, L., Salmen, W., Sankaran, B., Prasad, B.V.V. 2.87 X-RAY DIFFRACTION 0.294 0.251 False True IGHV1 NA NA None None None None None 8g0w H NA 0 F protein NA vp1 VIRAL PROTEIN 10/04/23 Crystal structure of human norovirus GII.4 P domain in complex with Nanobody M4 Lama glama; Norovirus lama glama norovirus Hu, L., Salmen, W., Sankaran, B., Prasad, B.V.V. 2.87 X-RAY DIFFRACTION 0.294 0.251 False True IGHV1 NA NA None None None None None 8gy5 A B 0 Q protein NA programmed cell death protein 1 IMMUNE SYSTEM 10/04/23 High-resolution structure of the cemiplimab Fab in complex with PD-1 Homo sapiens homo sapiens homo sapiens homo sapiens Heo, Y.-S., Jeong, T.J. 1.98 X-RAY DIFFRACTION 0.236 0.187 False True IGHV3 IGKV1 Kappa None None None None None 8gy5 H L 0 P protein NA programmed cell death protein 1 IMMUNE SYSTEM 10/04/23 High-resolution structure of the cemiplimab Fab in complex with PD-1 Homo sapiens homo sapiens homo sapiens homo sapiens Heo, Y.-S., Jeong, T.J. 1.98 X-RAY DIFFRACTION 0.236 0.187 False True IGHV3 IGKV1 Kappa None None None None None 8h63 B NA 0 A protein NA internalin a CELL INVASION/IMMUNE SYSTEM 10/04/23 Crystal structure of Internalin A from Listeria monocytogenes with nanobody VHH10 bound Lama glama; Listeria monocytogenes serovar 1/2a lama glama listeria monocytogenes serovar 1/2a Caaveiro, J.M.M., Nagatoish, S., Tsumoto, K. 1.53 X-RAY DIFFRACTION 0.190 0.161 False True IGHV1 NA NA None None None None None 8h64 B NA 0 A protein NA internalin a CELL INVASION/IMMUNE SYSTEM 10/04/23 Crystal structure of Internalin A from Listeria monocytogenes with nanobody VHH24 bound Lama glama; Listeria monocytogenes serovar 1/2a lama glama listeria monocytogenes serovar 1/2a Caaveiro, J.M.M., Nagatoish, S., Tsumoto, K. 2.35 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 NA NA None None None None None 8h64 D NA 0 C protein NA internalin a CELL INVASION/IMMUNE SYSTEM 10/04/23 Crystal structure of Internalin A from Listeria monocytogenes with nanobody VHH24 bound Lama glama; Listeria monocytogenes serovar 1/2a lama glama listeria monocytogenes serovar 1/2a Caaveiro, J.M.M., Nagatoish, S., Tsumoto, K. 2.35 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 NA NA None None None None None 8h64 F NA 0 E protein NA internalin a CELL INVASION/IMMUNE SYSTEM 10/04/23 Crystal structure of Internalin A from Listeria monocytogenes with nanobody VHH24 bound Lama glama; Listeria monocytogenes serovar 1/2a lama glama listeria monocytogenes serovar 1/2a Caaveiro, J.M.M., Nagatoish, S., Tsumoto, K. 2.35 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 NA NA None None None None None 8h64 H NA 0 G protein NA internalin a CELL INVASION/IMMUNE SYSTEM 10/04/23 Crystal structure of Internalin A from Listeria monocytogenes with nanobody VHH24 bound Lama glama; Listeria monocytogenes serovar 1/2a lama glama listeria monocytogenes serovar 1/2a Caaveiro, J.M.M., Nagatoish, S., Tsumoto, K. 2.35 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 NA NA None None None None None 8hlb B C 0 A protein NA tumor necrosis factor receptor superfamily member 1b,maltose/maltodextrin-binding periplasmic protein IMMUNE SYSTEM 10/04/23 Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2 Escherichia coli (strain K12); Homo sapiens homo sapiens homo sapiens homo sapiens, escherichia coli (strain k12) Akiba, H., Fujita, J., Ise, T., Nishiyama, K., Miyata, T., Kato, T., Namba, K., Ohno, H., Kamada, H., Nagata, S., Tsumoto, K. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8hlb D E 0 A protein NA tumor necrosis factor receptor superfamily member 1b,maltose/maltodextrin-binding periplasmic protein IMMUNE SYSTEM 10/04/23 Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2 Escherichia coli (strain K12); Homo sapiens homo sapiens homo sapiens homo sapiens, escherichia coli (strain k12) Akiba, H., Fujita, J., Ise, T., Nishiyama, K., Miyata, T., Kato, T., Namba, K., Ohno, H., Kamada, H., Nagata, S., Tsumoto, K. 3.63 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8i3s H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Local CryoEM structure of the SARS-CoV-2 S6P in complex with 7B3 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Yu, F., Cao, S., ZHao, H. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8i3u H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 Local CryoEM structure of the SARS-CoV-2 S6P in complex with 14B1 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Yu, F., Cao, S. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8jz7 S s 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/04/23 Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, C., Tian, X.W., Liu, Y., Cheng, L., Yan, W., Shao, Z.H. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8s9g H L 0 E protein NA spike glycoprotein VIRAL PROTEIN 10/04/23 SARS-CoV-2 BN.1 spike RBD bound to the human ACE2 ectodomain and the S309 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8sai S s 0 D | E protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 LIPID BINDING PROTEIN 10/04/23 Cryo-EM structure of GPR34-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yong, X.H., Zhao, C., Yan, W., Shao, Z.H. 3.27 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8sak H L 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/04/23 BtCoV-422 in complex with neutralizing antibody JC57-11 Macaca; Middle East respiratory syndrome-related coronavirus macaca macaca middle east respiratory syndrome-relatedcoronavirus | middle east respiratory syndrome-relatedcoronavirus McFadden, E., McLellan, J.S. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8tb0 F f 0 R | B protein | protein NA | NA gpr61 fused to dominant negative g alpha s/i n18 chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/04/23 Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16 Escherichia coli; Homo sapiens homo sapiens escherichia coli, homo sapiens | homo sapiens Lees, J.A., Dias, J.M., Han, S. 3.47 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8euu G H 0 B | A protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/ IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euu I J 0 D | C protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/ IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euu K L 0 F | E protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/ IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euv G H 0 B | A protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01-COMBO1 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euv I J 0 D | C protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01-COMBO1 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euv K L 0 F | E protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01-COMBO1 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euw G H 0 B | A protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01-MM28 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euw I J 0 D | C protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01-MM28 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8euw K L 0 F | E protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/27/23 Cryo-EM structure of HIV-1 BG505 DS-SOSIP ENV trimer bound to VRC34.01-MM28 FAB Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pletnev, S., Kwong, P. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7zau B NA 0 A protein NA fascin STRUCTURAL PROTEIN 09/27/23 Fascin-1 in complex with Nb 3E11 Homo sapiens; Lama glama lama glama homo sapiens Burgess, S.G., Bayliss, R. 2.2 X-RAY DIFFRACTION 0.290 0.247 False True IGHV1 NA NA None None None None None 7zau D NA 0 C protein NA fascin STRUCTURAL PROTEIN 09/27/23 Fascin-1 in complex with Nb 3E11 Homo sapiens; Lama glama lama glama homo sapiens Burgess, S.G., Bayliss, R. 2.2 X-RAY DIFFRACTION 0.290 0.247 False True IGHV1 NA NA None None None None None 7zau F NA 0 E protein NA fascin STRUCTURAL PROTEIN 09/27/23 Fascin-1 in complex with Nb 3E11 Homo sapiens; Lama glama lama glama homo sapiens Burgess, S.G., Bayliss, R. 2.2 X-RAY DIFFRACTION 0.290 0.247 False True IGHV1 NA NA None None None None None 7zau H NA 0 G protein NA fascin STRUCTURAL PROTEIN 09/27/23 Fascin-1 in complex with Nb 3E11 Homo sapiens; Lama glama lama glama homo sapiens Burgess, S.G., Bayliss, R. 2.2 X-RAY DIFFRACTION 0.290 0.247 False True IGHV1 NA NA None None None None None 8bjz H L 0 NA NA NA NA IMMUNE SYSTEM 09/27/23 crystal structure of antibody Fab with SiaLac-amidine-Lys Mus musculus mus musculus mus musculus Moynie, L., Naismith, J.H. 1.89 X-RAY DIFFRACTION 0.223 0.186 False True IGHV2 IGKV6 Kappa None None None None None 8bjz A B 0 NA NA NA NA IMMUNE SYSTEM 09/27/23 crystal structure of antibody Fab with SiaLac-amidine-Lys Mus musculus mus musculus mus musculus Moynie, L., Naismith, J.H. 1.89 X-RAY DIFFRACTION 0.223 0.186 False True IGHV2 IGKV6 Kappa None None None None None 8bso H L 0 L Hapten SL9 (2~{S})-2-acetamido-6-(2-sulfanylethanimidoylamino)hexanamide IMMUNE SYSTEM 09/27/23 crystal structure of antibody Fab with SiaLac-amidine-Lys Mus musculus mus musculus mus musculus mus musculus Moynie, L., Naismith, J.H. 1.92 X-RAY DIFFRACTION 0.220 0.180 False True IGHV2 IGKV6 Kappa None None None None None 8bso C D 0 D Hapten SL9 (2~{S})-2-acetamido-6-(2-sulfanylethanimidoylamino)hexanamide IMMUNE SYSTEM 09/27/23 crystal structure of antibody Fab with SiaLac-amidine-Lys Mus musculus mus musculus mus musculus mus musculus Moynie, L., Naismith, J.H. 1.92 X-RAY DIFFRACTION 0.220 0.180 False True IGHV2 IGKV6 Kappa None None None None None 8cml A NA 0 B protein NA complement c5 alpha chain IMMUNE SYSTEM 09/27/23 Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2 Homo sapiens; Lama glama lama glama homo sapiens De la O Becerra, K.I., Gros, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cml C NA 0 B protein NA complement c5 alpha chain IMMUNE SYSTEM 09/27/23 Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2 Homo sapiens; Lama glama lama glama homo sapiens De la O Becerra, K.I., Gros, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cni A NA 0 B protein NA solute carrier family 15 member 4 MEMBRANE PROTEIN 09/27/23 PHT1 in the outward facing conformation, bound to Sb27 Escherichia coli; Homo sapiens homo sapiens Custodio, T., Killer, M., Loew, C. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cni C NA 0 B protein NA solute carrier family 15 member 4 MEMBRANE PROTEIN 09/27/23 PHT1 in the outward facing conformation, bound to Sb27 Escherichia coli; Homo sapiens homo sapiens Custodio, T., Killer, M., Loew, C. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8eli H L 0 A peptide NA fusion peptide IMMUNE SYSTEM 09/27/23 Broadly neutralizing antibody VRC34-combo.1 in complex with HIV fusion peptide (residue 512-519) Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 06tg.ht008 Xu, K., Kwong, P.D. 1.49 X-RAY DIFFRACTION 0.178 0.162 False True IGHV1 IGKV1 Kappa None None None None None 8gye B C 0 NA NA NA NA IMMUNE SYSTEM 09/27/23 Crystal Structure of the 4-1BB in complex with ZG033 Fab Homo sapiens homo sapiens homo sapiens Zhu, M., Cheng, L.S., Gao, Y. 2.3 X-RAY DIFFRACTION 0.277 0.222 False True IGHV2 IGKV10 Kappa None None None None None 8gye E F 0 A protein NA tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 09/27/23 Crystal Structure of the 4-1BB in complex with ZG033 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Zhu, M., Cheng, L.S., Gao, Y. 2.3 X-RAY DIFFRACTION 0.277 0.222 False True IGHV2 IGKV10 Kappa None None None None None 8pg0 H L 0 A protein NA solute carrier organic anion transporter family member 1b3 TRANSPORT PROTEIN 09/27/23 Human OATP1B3 Homo sapiens homo sapiens homo sapiens homo sapiens Ciuta, A.-D., Nosol, K., Kowal, J., Mukherjee, S., Ramirez, A.S., Stieger, B., Kossiakoff, A.A., Locher, K.P. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8phw H L 0 A protein NA solute carrier organic anion transporter family member 1b1 TRANSPORT PROTEIN 09/27/23 Human OATP1B1 Homo sapiens homo sapiens homo sapiens homo sapiens Ciuta, A.-D., Nosol, K., Kowal, J., Mukherjee, S., Ramirez, A.S., Stieger, B., Kossiakoff, A.A., Locher, K.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8t03 C D 0 A protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker bound to Fab18G7 in detergent Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8t03 E F 0 B protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker bound to Fab18G7 in detergent Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 2.72 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8t04 C D 0 A protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker bound to Fab18G7 in nanodiscs Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8t04 E F 0 B protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker bound to Fab18G7 in nanodiscs Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8t05 C D 0 A | B protein | protein NA | NA myomaker | myomaker MEMBRANE PROTEIN 09/27/23 Structure of Ciona Myomaker bound to Fab1A1 Ciona robusta; Mus musculus mus musculus mus musculus ciona robusta | ciona robusta Long, T., Li, X. 3.22 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV12 Kappa None None None None None 8t06 C D 0 A protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker mutant-R107A bound to Fab18G7 Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8t06 E F 0 B protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker mutant-R107A bound to Fab18G7 Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8t07 C D 0 A protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker mutant-Y118A bound to Fab18G7 Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8t07 E F 0 B protein NA protein myomaker MEMBRANE PROTEIN 09/27/23 Structure of mouse Myomaker mutant-Y118A bound to Fab18G7 Mus musculus mus musculus mus musculus mus musculus Long, T., Li, X. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV19 Kappa None None None None None 8u5b H L 0 A | B protein | protein NA | NA claudin-4 | heat-labile enterotoxin b chain MEMBRANE PROTEIN 09/27/23 Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1 Clostridium perfringens; Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens | clostridium perfringens Vecchio, A.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ecq H L 0 NA NA NA NA IMMUNE SYSTEM 09/20/23 Bovine Fab 2G3 Bos taurus; Homo sapiens bos taurus, homo sapiens bos taurus, homo sapiens Stanfield, R.L., Wilson, I.A. 2 X-RAY DIFFRACTION 0.253 0.214 False True IGHV1 IGLV1 Lambda None None None None None 8ecv H L 0 NA NA NA NA IMMUNE SYSTEM 09/20/23 Bovine Fab 2F12 Bos taurus; Homo sapiens bos taurus, homo sapiens bos taurus, homo sapiens Stanfield, R.L., Wilson, I.A. 1.81 X-RAY DIFFRACTION 0.261 0.219 False True IGHV1 IGLV1 Lambda None None None None None 8ecv B A 0 NA NA NA NA IMMUNE SYSTEM 09/20/23 Bovine Fab 2F12 Bos taurus; Homo sapiens bos taurus, homo sapiens bos taurus, homo sapiens Stanfield, R.L., Wilson, I.A. 1.81 X-RAY DIFFRACTION 0.261 0.219 False True IGHV1 IGLV1 Lambda None None None None None 8ecz H L 0 NA NA NA NA IMMUNE SYSTEM 09/20/23 Bovine Fab 4C1 Bos taurus; Homo sapiens bos taurus, homo sapiens bos taurus, homo sapiens Stanfield, R.L., Wilson, I.A. 2.82 X-RAY DIFFRACTION 0.258 0.244 False True IGHV1 IGLV1 Lambda None None None None None 8ecz B A 0 NA NA NA NA IMMUNE SYSTEM 09/20/23 Bovine Fab 4C1 Bos taurus; Homo sapiens bos taurus, homo sapiens bos taurus, homo sapiens Stanfield, R.L., Wilson, I.A. 2.82 X-RAY DIFFRACTION 0.258 0.244 False True IGHV1 IGLV1 Lambda None None None None None 8ed1 H L 0 NA NA NA NA IMMUNE SYSTEM 09/20/23 Bovine Fab 5C1 Bos taurus; Homo sapiens bos taurus, homo sapiens bos taurus, homo sapiens Stanfield, R.L., Wilson, I.A. 2.31 X-RAY DIFFRACTION 0.267 0.235 False True IGHV1 IGLV1 Lambda None None None None None 8edf H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 09/20/23 Bovine Fab SKD in complex with Sars COV-2 receptor binding domain Bos taurus; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 bos taurus, homo sapiens bos taurus severe acute respiratory syndrome coronavirus2 Stanfield, R.L., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.299 0.276 False True IGHV1 IGLV1 Lambda None None None None None 8foi H L 0 A protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and allopregnanolone Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8foi J K 0 C protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and allopregnanolone Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g4n H L 0 A protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroids Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g4n J K 0 C protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroids Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g4o H L 0 A protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 09/20/23 Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with didesethylflurazepam and endogenous GABA Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g4o J K 0 C protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 09/20/23 Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with didesethylflurazepam and endogenous GABA Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g4x H L 0 A protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.56 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g5f J K 0 C protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g5g H L 0 A protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8g5h J K 0 C protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 01/08/09 Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid Mus musculus mus musculus mus musculus mus musculus Sun, C., Gouaux, E. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8ioc N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,hibit MEMBRANE PROTEIN 09/20/23 Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex Bos taurus; Homo sapiens; Influenza A virus (strain A/Victoria/3/1975 H3N2); SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Feng, W.B., Zhou, Q.T., Chen, X.Y., Dai, A.T., Cai, X.Q., Liu, X., Zhao, F.H., Chen, Y., Ye, C.Y., Xu, Y.N., Cong, Z.T., Li, H., Lin, S. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8iod N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1,hibit MEMBRANE PROTEIN 09/20/23 Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex Bos taurus; Homo sapiens; Influenza A virus (strain A/Victoria/3/1975 H3N2); SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Feng, W.B., Zhou, Q.T., Chen, X.Y., Dai, A.T., Cai, X.Q., Liu, X., Zhao, F.H., Chen, Y., Ye, C.Y., Xu, Y.N., Cong, Z.T., Li, H., Lin, S., Yang, D.H., Wang, M.W. 2.59 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8j7t E C 0 A protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7t F D 0 B protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7u E C 0 A protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc-bound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7u F D 0 B protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc-bound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7v E C 0 A protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7v F D 0 B protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7w E C 0 A protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc state 2, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-bound conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7w F D 0 B protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc state 2, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-bound conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7x E C 0 A protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-unbound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7x F D 0 B protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-unbound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7y E C 0 A protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-bound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j7y F D 0 B protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7DeltaHis-loop-Fab complex in zinc-bound state, determined in outward-facing conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j80 E C 0 A protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8j80 F D 0 B protein NA zinc transporter 7 METAL TRANSPORT 09/20/23 Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Han, B.B., Inaba, K., Watanabe, S. 2.68 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8q6j B A 0 E protein NA receptor tyrosine-protein kinase erbb-2 STRUCTURAL PROTEIN 01/08/09 Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex Homo sapiens homo sapiens homo sapiens homo sapiens Ruedas, R., Vuillemot, R., Tubiana, T., Winter, J.M., Pieri, L., Arteni, A.A., Samson, C., Jonic, J., Mathieu, M., Bressanelli, S. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8q6j D C 0 E protein NA receptor tyrosine-protein kinase erbb-2 STRUCTURAL PROTEIN 01/08/09 Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex Homo sapiens homo sapiens homo sapiens homo sapiens Ruedas, R., Vuillemot, R., Tubiana, T., Winter, J.M., Pieri, L., Arteni, A.A., Samson, C., Jonic, J., Mathieu, M., Bressanelli, S. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8szy A B 0 T protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM,PROTEIN BINDING 09/20/23 Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT Homo sapiens homo sapiens homo sapiens homo sapiens Diong, S.J., Lee, P.S. 2.31 X-RAY DIFFRACTION 0.269 0.227 False True IGHV1 IGKV1 Kappa None None None None None 8szy H L 0 T protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM,PROTEIN BINDING 09/20/23 Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT Homo sapiens homo sapiens homo sapiens homo sapiens Diong, S.J., Lee, P.S. 2.31 X-RAY DIFFRACTION 0.269 0.227 False True IGHV4 IGKV3 Kappa None None None None None 8szy C D 0 U protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM,PROTEIN BINDING 09/20/23 Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT Homo sapiens homo sapiens homo sapiens homo sapiens Diong, S.J., Lee, P.S. 2.31 X-RAY DIFFRACTION 0.269 0.227 False True IGHV1 IGKV1 Kappa None None None None None 8szy I M 0 U protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM,PROTEIN BINDING 09/20/23 Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT Homo sapiens homo sapiens homo sapiens homo sapiens Diong, S.J., Lee, P.S. 2.31 X-RAY DIFFRACTION 0.269 0.227 False True IGHV4 IGKV3 Kappa None None None None None 8caf B A 0 H | F protein | protein NA | NA cullin-1 | nedd8 CELL CYCLE 09/13/23 N8C_Fab3b in complex with NEDD8-CUL1(WHB) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Duda, D.M., Yanishevski, D., Henneberg, L.T., Schulman, B.A. 2.66 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGKV1 Kappa None None None None None 8caf D C 0 E | G protein | protein NA | NA cullin-1 | nedd8 CELL CYCLE 09/13/23 N8C_Fab3b in complex with NEDD8-CUL1(WHB) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Duda, D.M., Yanishevski, D., Henneberg, L.T., Schulman, B.A. 2.66 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGKV1 Kappa None None None None None 7xy3 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Cryo-EM structure of SARS-CoV-2 spike in complex with VHH14 Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Cao, D., Fan, X., Zhang, X. 4.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7xy4 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Cryo-EM structure of SARS-CoV-2 spike in complex with VHH21 Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Cao, D., Fan, X., Zhang, X. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7xy4 E NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Cryo-EM structure of SARS-CoV-2 spike in complex with VHH21 Camelus bactrianus; Severe acute respiratory syndrome coronavirus 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Cao, D., Fan, X., Zhang, X. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y0n C L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7y0n E J 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7y0n F K 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7y0n G NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7y0n H NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7y0n I NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8ee2 C NA 0 A protein NA cftr inhibitory factor IMMUNE SYSTEM 09/13/23 Crystal Structure of Nanobody VHH219 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.227 0.195 False True IGHV1 NA NA None None None None None 8ee2 D NA 0 B protein NA cftr inhibitory factor IMMUNE SYSTEM 09/13/23 Crystal Structure of Nanobody VHH219 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.227 0.195 False True IGHV1 NA NA None None None None None 8ee2 G NA 0 E protein NA cftr inhibitory factor IMMUNE SYSTEM 09/13/23 Crystal Structure of Nanobody VHH219 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.227 0.195 False True IGHV1 NA NA None None None None None 8ee2 H NA 0 F protein NA cftr inhibitory factor IMMUNE SYSTEM 09/13/23 Crystal Structure of Nanobody VHH219 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.227 0.195 False True IGHV1 NA NA None None None None None 8ee2 K NA 0 I protein NA cftr inhibitory factor IMMUNE SYSTEM 09/13/23 Crystal Structure of Nanobody VHH219 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.227 0.195 False True IGHV1 NA NA None None None None None 8ee2 L NA 0 J protein NA cftr inhibitory factor IMMUNE SYSTEM 09/13/23 Crystal Structure of Nanobody VHH219 Bound to Its Antigen PA14 Cif Pseudomonas aeruginosa PA14; Vicugna pacos vicugna pacos pseudomonas aeruginosa pa14 Simard, A.R., Madden, D.R. 2.4 X-RAY DIFFRACTION 0.227 0.195 False True IGHV1 NA NA None None None None None 8f0i C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody COVA309-22 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 3.7 X-RAY DIFFRACTION 0.275 0.226 False True IGHV3 IGKV1 Kappa None None None None None 8f0i E F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody COVA309-22 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 3.7 X-RAY DIFFRACTION 0.275 0.226 False True IGHV3 IGKV1 Kappa None None None None None 8f0i H I 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody COVA309-22 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 3.7 X-RAY DIFFRACTION 0.275 0.226 False True IGHV3 IGKV1 Kappa None None None None None 8fx5 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/SIGNALING PROTEIN 09/13/23 Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline Homo sapiens; Mus musculus homo sapiens mus musculus | homo sapiens Vuckovic, Z., Mobbs, J.I., Glukhova, A., Sexton, P.M., Danev, R., Thal, D.M. 2.45 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ihb S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/13/23 Cryo-EM structure of HCA2-Gi complex with GSK256073 Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | mus musculus Suzuki, S., Nishikawa, K., Suzuki, H., Fujiyoshi, Y. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jiq N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 09/13/23 Cryo-EM structure of the GLP-1R/GCGR dual agonist Peptide 15-bound human GCGR-Gs complex Bos taurus; Escherichia coli; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Yang, L., Zhou, Q.T., Dai, A.T., Zhao, F.H., Chang, R.L., Ying, T.L., Wu, B.L., Yang, D.H., Wang, M.W., Cong, Z.T. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jiu N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 09/13/23 Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GCGR-Gs complex Bos taurus; Escherichia coli; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Yang, L., Zhou, Q.T., Dai, A.T., Zhao, F.H., Chang, R.L., Ying, T.L., Wu, B.L., Yang, D.H., Wang, M.W., Cong, Z.T. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8t7a D E 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Cryo-EM structure of RSV preF in complex with Fab 2.4K Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus McCool, R.S., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8t7a F G 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Cryo-EM structure of RSV preF in complex with Fab 2.4K Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus McCool, R.S., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8t7a H I 0 c protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 09/13/23 Cryo-EM structure of RSV preF in complex with Fab 2.4K Homo sapiens; Respiratory syncytial virus homo sapiens homo sapiens respiratory syncytial virus McCool, R.S., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8ty1 C B 0 A protein NA coagulation factor viii BLOOD CLOTTING/INHIBITOR 09/13/23 Cryo-EM structure of coagulation factor VIII bound to NB2E9 Homo sapiens; Sus scrofa homo sapiens homo sapiens sus scrofa, homo sapiens Childers, K.C., Spiegel, P.C. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6b3m C D 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/13/18 The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin Homo sapiens; unidentified influenza virus homo sapiens homo sapiens unidentified influenza virus | unidentified influenza virus Shore, D.A., Yang, H., Stevens, J. 3.92 X-RAY DIFFRACTION 0.329 0.286 False True IGHV1 IGKV3 Kappa None None None None None 6b3m I J 0 H | K protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/13/18 The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin Homo sapiens; unidentified influenza virus homo sapiens homo sapiens unidentified influenza virus | unidentified influenza virus Shore, D.A., Yang, H., Stevens, J. 3.92 X-RAY DIFFRACTION 0.329 0.286 False True IGHV1 IGKV3 Kappa None None None None None 6b3m M N 0 F | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/13/18 The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin Homo sapiens; unidentified influenza virus homo sapiens homo sapiens unidentified influenza virus | unidentified influenza virus Shore, D.A., Yang, H., Stevens, J. 3.92 X-RAY DIFFRACTION 0.329 0.286 False True IGHV1 IGKV3 Kappa None None None None None 6b3m O P 0 L | G protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/13/18 The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin Homo sapiens; unidentified influenza virus homo sapiens homo sapiens unidentified influenza virus | unidentified influenza virus Shore, D.A., Yang, H., Stevens, J. 3.92 X-RAY DIFFRACTION 0.329 0.286 False True IGHV1 IGKV3 Kappa None None None None None 6b3m V W 0 T | S protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/13/18 The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin Homo sapiens; unidentified influenza virus homo sapiens homo sapiens unidentified influenza virus | unidentified influenza virus Shore, D.A., Yang, H., Stevens, J. 3.92 X-RAY DIFFRACTION 0.329 0.286 False True IGHV1 IGKV3 Kappa None None None None None 6b3m Y U 0 R | Q protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/13/18 The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin Homo sapiens; unidentified influenza virus homo sapiens homo sapiens unidentified influenza virus | unidentified influenza virus Shore, D.A., Yang, H., Stevens, J. 3.92 X-RAY DIFFRACTION 0.329 0.286 False True IGHV1 IGKV3 Kappa None None None None None 6e0c M m 0 C | D | B | A protein | protein | protein | protein NA | NA | NA | NA histone h2a type 1-b/e | histone h2b type 1-j | histone h4 | histone h3-like centromeric protein a NUCLEAR PROTEIN 05/22/19 Cryo-EM structure of the CENP-A nucleosome (W601) in complex with a single chain antibody fragment Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens | homo sapiens Yadav, K.N.S., Zhou, B.-R. 2.63 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6e0c N n 0 G | H | E protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h2b type 1-j | histone h3-like centromeric protein a NUCLEAR PROTEIN 05/22/19 Cryo-EM structure of the CENP-A nucleosome (W601) in complex with a single chain antibody fragment Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Yadav, K.N.S., Zhou, B.-R. 2.63 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6dzt M m 0 G | F | H protein | protein | protein NA | NA | NA histone h2a | histone h4 | histone h2b NUCLEAR PROTEIN 05/22/19 Cryo-EM structure of nucleosome in complex with a single chain antibody fragment Drosophila melanogaster; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Yadav, K.N.S., Zhou, B.-R. 2.99 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6dzt N n 0 C | D | B protein | protein | protein NA | NA | NA histone h2a | histone h2b | histone h4 NUCLEAR PROTEIN 05/22/19 Cryo-EM structure of nucleosome in complex with a single chain antibody fragment Drosophila melanogaster; Mus musculus; SYNTHETIC CONSTRUCT mus musculus drosophila melanogaster | drosophila melanogaster | drosophila melanogaster Yadav, K.N.S., Zhou, B.-R. 2.99 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5fuu H L 0 D | C protein | protein NA | NA hiv-1 envelope glycoprotein gp160 | hiv-1 envelope glycoprotein gp160 VIRAL PROTEIN 01/08/09 Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.19 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 5fuu M N 0 F | B | E protein | protein | protein NA | NA | NA hiv-1 envelope glycoprotein gp160 | hiv-1 envelope glycoprotein gp160 | hiv-1 envelope glycoprotein gp160 VIRAL PROTEIN 01/08/09 Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.19 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 6qxe M NA 0 E | F protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit RNA BINDING PROTEIN 09/04/19 Influenza A virus (A/NT/60/1968) polymerase dimer of hetermotrimer in complex with 3'5' cRNA promoter and Nb8205 Influenza A virus (A/nt/60/1968(H3N2)); SYNTHETIC CONSTRUCT influenza a virus (a/nt/60/1968(h3n2)) influenza a virus (a/nt/60/1968(h3n2)) | influenza a virus (a/nt/60/1968(h3n2)) Carrique, L., Keown, J.R., Fan, H., Fodor, E., Grimes, J.M. 4.15 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6qxe O NA 0 A | B protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit RNA BINDING PROTEIN 09/04/19 Influenza A virus (A/NT/60/1968) polymerase dimer of hetermotrimer in complex with 3'5' cRNA promoter and Nb8205 Influenza A virus (A/nt/60/1968(H3N2)); SYNTHETIC CONSTRUCT influenza a virus (a/nt/60/1968(h3n2)) influenza a virus (a/nt/60/1968(h3n2)) | influenza a virus (a/nt/60/1968(h3n2)) Carrique, L., Keown, J.R., Fan, H., Fodor, E., Grimes, J.M. 4.15 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7k78 K k 0 C | D | B protein | protein | protein NA | NA | NA histone h2a.1 | histone h2b.1 | histone h4 DNA BINDING PROTEIN/DNA 03/31/21 antibody and nucleosome complex Mus musculus; Saccharomyces cerevisiae; Saccharomyces cerevisiae (strain ATCC 204508 / S288c) mus musculus saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) Ruifang, G., Yawen, B. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7k78 L l 0 G | F | H protein | protein | protein NA | NA | NA histone h2a.1 | histone h4 | histone h2b.1 DNA BINDING PROTEIN/DNA 03/31/21 antibody and nucleosome complex Mus musculus; Saccharomyces cerevisiae; Saccharomyces cerevisiae (strain ATCC 204508 / S288c) mus musculus saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) Ruifang, G., Yawen, B. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5js9 A B 0 C protein NA gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/16 Uncleaved prefusion optimized gp140 trimer with an engineered 8-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, L., Wilson, I.A. 6.918 X-RAY DIFFRACTION 0.322 0.284 False True unknown IGLV2 Lambda None None None None None 5js9 E F 0 C | D protein | protein NA | NA gp120 | gp41 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/16 Uncleaved prefusion optimized gp140 trimer with an engineered 8-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Kong, L., Wilson, I.A. 6.918 X-RAY DIFFRACTION 0.322 0.284 False True unknown IGKV1 Kappa None None None None None 6e0p M m 0 C | D | B | A protein | protein | protein | protein NA | NA | NA | NA histone h2a type 1-b/e | histone h2b type 1-j | histone h4 | histone h3-like centromeric protein a NUCLEAR PROTEIN 05/22/19 Cryo-EM structure of the centromeric nucleosome (Native alpha satellite DNA) in complex with a single chain antibody fragment Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens | homo sapiens Yadav, K.N.S., Zhou, B.-R. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6e0p N n 0 G | F | H | E protein | protein | protein | protein NA | NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j | histone h3-like centromeric protein a NUCLEAR PROTEIN 05/22/19 Cryo-EM structure of the centromeric nucleosome (Native alpha satellite DNA) in complex with a single chain antibody fragment Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens | homo sapiens Yadav, K.N.S., Zhou, B.-R. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4kv5 J j 0 B protein NA transforming growth factor beta-1 proprotein IMMUNE SYSTEM 09/24/14 scFv GC1009 in complex with TGF-beta1. Homo sapiens homo sapiens homo sapiens Wei, R., Moulin, A.G., Mathieu, M. 3 X-RAY DIFFRACTION 0.300 0.229 True True unknown unknown unknown None None None None None 4kv5 H h 0 A protein NA transforming growth factor beta-1 proprotein IMMUNE SYSTEM 09/24/14 scFv GC1009 in complex with TGF-beta1. Homo sapiens homo sapiens homo sapiens Wei, R., Moulin, A.G., Mathieu, M. 3 X-RAY DIFFRACTION 0.300 0.229 True True unknown unknown unknown None None None None None 4kv5 E e 0 C protein NA transforming growth factor beta-1 proprotein IMMUNE SYSTEM 09/24/14 scFv GC1009 in complex with TGF-beta1. Homo sapiens homo sapiens homo sapiens Wei, R., Moulin, A.G., Mathieu, M. 3 X-RAY DIFFRACTION 0.300 0.229 True True unknown unknown unknown None None None None None 4kv5 G g 0 D protein NA transforming growth factor beta-1 proprotein IMMUNE SYSTEM 09/24/14 scFv GC1009 in complex with TGF-beta1. Homo sapiens homo sapiens homo sapiens Wei, R., Moulin, A.G., Mathieu, M. 3 X-RAY DIFFRACTION 0.300 0.229 True True unknown unknown unknown None None None None None 8ee8 H L 0 Z | A protein | protein NA | NA envelope protein e | envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ100-C in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 | zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 2.803 X-RAY DIFFRACTION 0.296 0.241 False True IGHV3 IGLV11 Lambda None None None None None 8ee8 D C 0 B protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ100-C in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 2.803 X-RAY DIFFRACTION 0.296 0.241 False True IGHV3 IGLV11 Lambda None None None None None 7y0o H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/06/23 Interface of SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7y0o B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/06/23 Interface of SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, L. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yub H L 0 NA NA NA NA MEMBRANE PROTEIN 09/06/23 S1P-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct synthetic construct synthetic construct He, Y., Duan, Y. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7yub N NA 0 R protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 09/06/23 S1P-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens He, Y., Duan, Y. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yud H L 0 R protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 09/06/23 FTY720p-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct (code 12) synthetic construct (code 12) synthetic construct (code 12) homo sapiens He, Y., Duan, Y. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7yud N NA 0 R protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 09/06/23 FTY720p-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct (code 12) lama glama homo sapiens He, Y., Duan, Y. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yud K NA 0 NA NA NA NA MEMBRANE PROTEIN 09/06/23 FTY720p-bound human SPNS2 Homo sapiens; Lama glama; synthetic construct (code 12) lama glama He, Y., Duan, Y. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yuf H L 0 R protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 09/06/23 apo human SPNS2 Homo sapiens; Lama glama; synthetic construct synthetic construct synthetic construct homo sapiens He, Y., Duan, Y. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7yuf N NA 0 R protein NA sphingosine-1-phosphate transporter spns2 MEMBRANE PROTEIN 09/06/23 apo human SPNS2 Homo sapiens; Lama glama; synthetic construct lama glama homo sapiens He, Y., Duan, Y. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yuf K NA 0 NA NA NA NA MEMBRANE PROTEIN 09/06/23 apo human SPNS2 Homo sapiens; Lama glama; synthetic construct lama glama He, Y., Duan, Y. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z1x B NA 0 A protein NA gasdermin-d IMMUNE SYSTEM 09/06/23 Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6 Homo sapiens; Lama glama lama glama homo sapiens Kopp, A., Hagelueken, G., Geyer, M. 1.86 X-RAY DIFFRACTION 0.249 0.212 False True IGHV1 NA NA None None None None None 7z1x C NA 0 A protein NA gasdermin-d IMMUNE SYSTEM 09/06/23 Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6 Homo sapiens; Lama glama lama glama homo sapiens Kopp, A., Hagelueken, G., Geyer, M. 1.86 X-RAY DIFFRACTION 0.249 0.212 False True IGHV3 NA NA None None None None None 7z1x E NA 0 D protein NA gasdermin-d IMMUNE SYSTEM 09/06/23 Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6 Homo sapiens; Lama glama lama glama homo sapiens Kopp, A., Hagelueken, G., Geyer, M. 1.86 X-RAY DIFFRACTION 0.249 0.212 False True IGHV1 NA NA None None None None None 7z1x F NA 0 D protein NA gasdermin-d IMMUNE SYSTEM 09/06/23 Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6 Homo sapiens; Lama glama lama glama homo sapiens Kopp, A., Hagelueken, G., Geyer, M. 1.86 X-RAY DIFFRACTION 0.249 0.212 False True IGHV3 NA NA None None None None None 8awl H L 0 NA NA NA NA IMMUNE SYSTEM 09/06/23 Fab RVFV-268 Homo sapiens homo sapiens homo sapiens Hulswit, R.J.G., Bowden, T.A., Stass, R. 1.62 X-RAY DIFFRACTION 0.219 0.202 False True IGHV3 IGLV3 Lambda None None None None None 8awm H L 0 A protein NA glycoprotein VIRAL PROTEIN 09/06/23 RVFV GnH with Fab268 bound Homo sapiens; Rift Valley fever virus homo sapiens homo sapiens rift valley fever virus Hulswit, R.J.G., Bowden, T.A., Stass, R. 3.5 X-RAY DIFFRACTION 0.279 0.247 False True IGHV3 IGLV3 Lambda None None None None None 8fgx B A 0 C protein NA plasma kallikrein light chain HYDROLASE/IMMUNE SYSTEM 09/06/23 Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein Homo sapiens homo sapiens homo sapiens homo sapiens Fuller, J.R., Biris, N., Bista, P. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8fwh H L 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Crystal structure of bivalent antibody Fab fragment of Anti-human LAG3 (22D2) Mus musculus Mishra, A.K., Agnihotri, P., Mariuzza, R.A. 2.833 X-RAY DIFFRACTION 0.277 0.216 False False IGHV1 IGKV3 Kappa None None None None None 8gsb H K 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/06/23 SARS-COV-2 BA.1 Spike incomplex with VacBB-665 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, C.C., Ju, B., Shen, S.L., Zhang, Z. 3.99 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8gsi B A 0 NA NA NA NA IMMUNE SYSTEM 09/06/23 Structure of the cobolimab Fab Camelus bactrianus; Homo sapiens homo sapiens homo sapiens Heo, Y.S., Choi, S.B. 2.02 X-RAY DIFFRACTION 0.233 0.197 False True IGHV3 IGKV1 Kappa None None None None None 8gsi F NA 0 NA NA NA NA IMMUNE SYSTEM 09/06/23 Structure of the cobolimab Fab Camelus bactrianus; Homo sapiens camelus bactrianus Heo, Y.S., Choi, S.B. 2.02 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 NA NA None None None None None 8j7e A B 0 F protein NA soluble cytochrome b562 IMMUNE SYSTEM 09/06/23 Crystal structure of BRIL in complex with 1b3 Fab Escherichia coli; Homo sapiens homo sapiens homo sapiens escherichia coli Zhong, Y.X., Guo, Q., Tao, Y.Y. 2.8 X-RAY DIFFRACTION 0.251 0.200 False True IGHV3 IGKV1 Kappa None None None None None 8j7e C D 0 E protein NA soluble cytochrome b562 IMMUNE SYSTEM 09/06/23 Crystal structure of BRIL in complex with 1b3 Fab Escherichia coli; Homo sapiens homo sapiens homo sapiens escherichia coli Zhong, Y.X., Guo, Q., Tao, Y.Y. 2.8 X-RAY DIFFRACTION 0.251 0.200 False True IGHV3 IGKV1 Kappa None None None None None 8jhy S s 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/06/23 Cryo-EM structure of compound 9n bound ketone body receptor HCAR2-Gi signaling complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, C., Tian, X.W., Liu, Y., Cheng, L., Yan, W., Shao, Z.H. 2.87 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jii S s 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/06/23 Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, C., Tian, X.W., Liu, Y., Cheng, L., Yan, W., Shao, Z.H. 3.17 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jil S s 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/06/23 Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, C., Tian, X.W., Liu, Y., Cheng, L., Yan, W., Shao, Z.H. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jim S s 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/06/23 Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, C., Tian, X.W., Liu, Y., Cheng, L., Yan, W., Shao, Z.H. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jip N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 09/06/23 Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GLP-1R-Gs complex Bos taurus; Escherichia coli; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Yang, L., Zhou, Q.T., Dai, A.T., Zhao, F.H., Chang, R.L., Ying, T.L., Wu, B.L., Yang, D.H., Wang, M.W., Cong, Z.T. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jir N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 09/06/23 Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GLP-1R-Gs complex Bos taurus; Escherichia coli; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Yang, L., Zhou, Q.T., Dai, A.T., Zhao, F.H., Chang, R.L., Ying, T.L., Wu, B.L., Yang, D.H., Wang, M.W., Cong, Z.T. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8jit N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 09/06/23 Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GCGR-Gs complex Bos taurus; Escherichia coli; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Yang, L., Zhou, Q.T., Dai, A.T., Zhao, F.H., Chang, R.L., Ying, T.L., Wu, B.L., Yang, D.H., Wang, M.W., Cong, Z.T. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8so3 H L 0 D protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 09/06/23 CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Mishra, A.K., Shahid, S., Karade, S.S., Mariuzza, R.A. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8so3 Y Z 0 X protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 09/06/23 CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Mishra, A.K., Shahid, S., Karade, S.S., Mariuzza, R.A. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8sr0 Y Z 0 X protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 09/06/23 CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Mishra, A.K., Shahid, S., Karade, S.S., Mariuzza, R.A. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8sr0 H L 0 D protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 09/06/23 CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Mishra, A.K., Shahid, S., Karade, S.S., Mariuzza, R.A. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8eh5 H L 0 G peptide NA circumsporozoite protein IMMUNE SYSTEM 06/28/23 Cryo-EM structure of L9 Fab in complex with rsCSP Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8eh5 M N 0 G peptide NA circumsporozoite protein IMMUNE SYSTEM 06/28/23 Cryo-EM structure of L9 Fab in complex with rsCSP Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8eh5 O P 0 G peptide NA circumsporozoite protein IMMUNE SYSTEM 06/28/23 Cryo-EM structure of L9 Fab in complex with rsCSP Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.36 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gpy C D 0 B protein NA spike protein s1 VIRAL PROTEIN 06/28/23 Crystal structure of Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, Y.X., Song, Z.D., Wang, W.M., Guo, Y. 2.51 X-RAY DIFFRACTION 0.251 0.215 True True IGHV3 IGLV2 Lambda None None None None None 8gpy E F 0 A protein NA spike protein s1 VIRAL PROTEIN 06/28/23 Crystal structure of Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, Y.X., Song, Z.D., Wang, W.M., Guo, Y. 2.51 X-RAY DIFFRACTION 0.251 0.215 True True IGHV3 IGLV2 Lambda None None None None None 7yi6 D B 0 A peptide NA spike glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 bnAb 3D1 in complex with 6-mer HR1 peptide from HCoV-229E S protein Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Yan, L., Yang, G. 2.28 X-RAY DIFFRACTION 0.220 0.193 False True IGHV7 IGLV2 Lambda None None None None None 7yi6 F E 0 C peptide NA spike glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 bnAb 3D1 in complex with 6-mer HR1 peptide from HCoV-229E S protein Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Yan, L., Yang, G. 2.28 X-RAY DIFFRACTION 0.220 0.193 False True IGHV7 IGLV2 Lambda None None None None None 8ee5 H L 0 Z protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ119-D in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 3.583 X-RAY DIFFRACTION 0.296 0.249 False True IGHV5 IGLV3 Lambda None None None None None 8eed H L 0 A protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 3.487 X-RAY DIFFRACTION 0.331 0.289 False True IGHV4 IGLV11 Lambda None None None None None 8eed M N 0 D protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 3.487 X-RAY DIFFRACTION 0.331 0.289 False True IGHV4 IGLV11 Lambda None None None None None 8eed E F 0 B protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 3.487 X-RAY DIFFRACTION 0.331 0.289 False True IGHV4 IGLV11 Lambda None None None None None 8eed I J 0 C protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 3.487 X-RAY DIFFRACTION 0.331 0.289 False True IGHV4 IGLV11 Lambda None None None None None 8eee H L 0 E protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ104-d in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 2.819 X-RAY DIFFRACTION 0.275 0.217 False True IGHV3 IGLV11 Lambda None None None None None 8eee A B 0 Z protein NA envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ104-d in complex with ZIKV E glycoprotein Macaca mulatta; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 macaca mulatta macaca mulatta zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sankhala, R.S., Joyce, M.G. 2.819 X-RAY DIFFRACTION 0.275 0.217 False True IGHV3 IGLV11 Lambda None None None None None 8eez H L 0 NA NA NA NA IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ100-C Macaca mulatta macaca mulatta macaca mulatta Sankhala, R.S., Joyce, M.G. 2.25 X-RAY DIFFRACTION 0.233 0.186 False True IGHV3 IGLV11 Lambda None None None None None 8ef0 H L 0 NA NA NA NA IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ104-D Macaca mulatta macaca mulatta macaca mulatta Sankhala, R.S., Joyce, M.G. 2.55 X-RAY DIFFRACTION 0.240 0.185 False True IGHV3 IGLV11 Lambda None None None None None 8ef1 H L 0 NA NA NA NA IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ103-A Macaca mulatta macaca mulatta macaca mulatta Sankhala, R.S., Joyce, M.G. 1.87 X-RAY DIFFRACTION 0.203 0.173 False True IGHV4 IGLV1 Lambda None None None None None 8ef2 H L 0 NA NA NA NA IMMUNE SYSTEM 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B Macaca mulatta macaca mulatta macaca mulatta Sankhala, R.S., Joyce, M.G. 2.102 X-RAY DIFFRACTION 0.217 0.172 False True IGHV4 IGLV11 Lambda None None None None None 8ef3 A B 0 NA NA NA NA VIRAL PROTEIN 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ119-D Macaca mulatta macaca mulatta macaca mulatta Sankhala, R.S., Joyce, M.G. 1.672 X-RAY DIFFRACTION 0.198 0.182 False True IGHV5 IGLV3 Lambda None None None None None 8ef3 C D 0 NA NA NA NA VIRAL PROTEIN 08/30/23 Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ119-D Macaca mulatta macaca mulatta macaca mulatta Sankhala, R.S., Joyce, M.G. 1.672 X-RAY DIFFRACTION 0.198 0.182 False True IGHV5 IGLV3 Lambda None None None None None 8fcz C NA 0 A protein NA rhodopsin MEMBRANE PROTEIN 08/30/23 Crystal structure of ground-state rhodopsin in complex with a nanobody Bos taurus; Lama glama lama glama bos taurus Salom, D., Palczewski, K., Kiser, P.D. 3.7 X-RAY DIFFRACTION 0.332 0.281 False True IGHV3 NA NA None None None None None 8fcz D NA 0 B protein NA rhodopsin MEMBRANE PROTEIN 08/30/23 Crystal structure of ground-state rhodopsin in complex with a nanobody Bos taurus; Lama glama lama glama bos taurus Salom, D., Palczewski, K., Kiser, P.D. 3.7 X-RAY DIFFRACTION 0.332 0.281 False True IGHV3 NA NA None None None None None 8fd0 C NA 0 A protein NA rhodopsin MEMBRANE PROTEIN 08/30/23 Crystal structure of bovine rod opsin in complex with a nanobody Bos taurus; Lama glama lama glama bos taurus Salom, D., Palczewski, K., Kiser, P.D. 3.71 X-RAY DIFFRACTION 0.295 0.292 False True IGHV3 NA NA None None None None None 8fd0 D NA 0 B protein NA rhodopsin MEMBRANE PROTEIN 08/30/23 Crystal structure of bovine rod opsin in complex with a nanobody Bos taurus; Lama glama lama glama bos taurus Salom, D., Palczewski, K., Kiser, P.D. 3.71 X-RAY DIFFRACTION 0.295 0.292 False True IGHV3 NA NA None None None None None 8fd1 C NA 0 A protein NA rhodopsin MEMBRANE PROTEIN 08/30/23 Crystal structure of photoactivated rhodopsin in complex with a nanobody Bos taurus; Lama glama lama glama bos taurus Salom, D., Palczewski, K., Kiser, P.D. 4.25 X-RAY DIFFRACTION 0.295 0.279 False True IGHV3 NA NA None None None None None 8fd1 D NA 0 B protein NA rhodopsin MEMBRANE PROTEIN 08/30/23 Crystal structure of photoactivated rhodopsin in complex with a nanobody Bos taurus; Lama glama lama glama bos taurus Salom, D., Palczewski, K., Kiser, P.D. 4.25 X-RAY DIFFRACTION 0.295 0.279 False True IGHV3 NA NA None None None None None 8gh4 H L 0 E protein NA disintegrin and metalloproteinase domain-containing protein10 IMMUNE SYSTEM 08/30/23 Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody Bos taurus; Homo sapiens homo sapiens homo sapiens bos taurus Nikolov, D.B., Saha, N., Xu, K., Goldgur, Y. 3.8 X-RAY DIFFRACTION 0.312 0.288 False True IGHV3 IGKV1 Kappa None None None None None 8gho A B 0 C peptide NA guanylyl cyclase c peptide PROTEIN BINDING 08/30/23 GUCY2C-peptide bound to anti-GUCY2C-scFv antibody Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Mosyak, L. 1.6 X-RAY DIFFRACTION 0.217 0.197 True True IGHV3 IGKV1 Kappa None None None None None 8gho H L 0 G peptide NA guanylyl cyclase c peptide PROTEIN BINDING 08/30/23 GUCY2C-peptide bound to anti-GUCY2C-scFv antibody Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Mosyak, L. 1.6 X-RAY DIFFRACTION 0.217 0.197 True True IGHV3 IGKV1 Kappa None None None None None 8ghp H L 0 A protein NA guanylyl cyclase c PROTEIN BINDING 08/30/23 GUCY2C-ECD bound to anti-GUCY2C-scFv antibody Homo sapiens homo sapiens homo sapiens homo sapiens Mosyak, L. 3.52 X-RAY DIFFRACTION 0.282 0.274 True True IGHV3 IGKV1 Kappa None None None None None 8gnh H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 08/30/23 Complex structure of BD-218 and Spike protein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, B., Xu, H., Su, X.D. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8gq1 H L 0 C protein NA lysozyme c IMMUNE SYSTEM 08/30/23 HyHEL10 Fab complexed with hen egg lysozyme carrying arginine cluster in framework region of light chain. Gallus gallus; Mus musculus mus musculus mus musculus gallus gallus Matsuura, H., Hirata, K., Sakai, N., Nakakido, M., Tsumoto, K. 3.13 X-RAY DIFFRACTION 0.267 0.230 False True IGHV3 IGKV5 Kappa None None None None None 8h7l D G 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Cryo-EM Structure of SARS-CoV-2 BA.2 Spike protein in complex with BA7535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Yan, A., Gao, Y. 2.44 ELECTRON MICROSCOPY NA NA False True IGHV3 unknown unknown None None None None None 8h7l E H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Cryo-EM Structure of SARS-CoV-2 BA.2 Spike protein in complex with BA7535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Yan, A., Gao, Y. 2.44 ELECTRON MICROSCOPY NA NA False True IGHV3 unknown unknown None None None None None 8h7l F I 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Cryo-EM Structure of SARS-CoV-2 BA.2 Spike protein in complex with BA7535 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Yan, A., Gao, Y. 2.44 ELECTRON MICROSCOPY NA NA False True IGHV3 unknown unknown None None None None None 8h7z F I 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/23 Cryo-EM structure of SARS-CoV-2 BA.2 RBD in complex with BA7535 fab (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Yan, A., Gao, Y. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV3 unknown unknown None None None None None 8hrh A B 0 D carbohydrate A2G N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE IMMUNE SYSTEM 08/30/23 SN-131/1B2 anti-MUC1 antibody with a glycopeptide Mus musculus mus musculus mus musculus Wakui, H., Horidome, C., Yao, M., Ose, T., Nishimura, S.-I. 2.07 X-RAY DIFFRACTION 0.227 0.192 False True IGHV1 IGKV1 Kappa None None None None None 8ihf S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/30/23 Cryo-EM structure of HCA2-Gi complex with MK6892 Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | mus musculus Suzuki, S., Nishikawa, K., Suzuki, H., Fujiyoshi, Y. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ihh S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/30/23 Cryo-EM structure of HCA2-Gi complex with LUF6283 Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | mus musculus Suzuki, S., Nishikawa, K., Suzuki, H., Fujiyoshi, Y. 3.06 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ihi S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/30/23 Cryo-EM structure of HCA2-Gi complex with acifran Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | mus musculus Suzuki, S., Nishikawa, K., Suzuki, H., Fujiyoshi, Y. 3.11 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ihj S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/30/23 Cryo-EM structure of HCA3-Gi complex with acifran Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | mus musculus Suzuki, S., Nishikawa, K., Suzuki, H., Fujiyoshi, Y. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8p7w D G 0 B protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8p7w F E 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8p7w C NA 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8p7w Y NA 0 B protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8p8a D C 0 B protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb17)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8p8a F E 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb17)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8p8a Z NA 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb17)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8p8j F E 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8p8j D C 0 B protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 8p8j Z NA 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/30/23 Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2 Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens Irobalieva, R.N., Manolaridis, I., Jackson, S.M., Ni, D., Pardon, E., Stahlberg, H., Steyaert, J., Locher, K.P. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8sgo J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN/IMMUNE SYSTEM 08/30/23 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Legesse, D.H., Fan, C., Teng, J., Zhuang, Y., Howard, R.J., Noviello, C.M., Lindahl, E., Hibbs, R.E. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8sgo K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN/IMMUNE SYSTEM 08/30/23 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Legesse, D.H., Fan, C., Teng, J., Zhuang, Y., Howard, R.J., Noviello, C.M., Lindahl, E., Hibbs, R.E. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8si9 J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 08/30/23 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Legesse, D.H., Hibbs, R.E. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8si9 K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 08/30/23 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Legesse, D.H., Hibbs, R.E. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8sid J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 08/30/23 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus dehydroepiandrosterone sulfate Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Legesse, D.H., Hibbs, R.E. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8sid K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 08/30/23 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus dehydroepiandrosterone sulfate Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Legesse, D.H., Hibbs, R.E. 2.71 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8apy C NA 0 A protein NA er lumen protein-retaining receptor 2 MEMBRANE PROTEIN 08/23/23 Crystal structure of the H12A variant of the KDEL receptor bound to sybody Gallus gallus; synthetic construct synthetic construct gallus gallus Parker, J.L., Smith, K., Newstead, S. 2.34 X-RAY DIFFRACTION 0.329 0.268 False True IGHV1 NA NA None None None None None 8gf2 C D 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/23/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.851 X-RAY DIFFRACTION 0.252 0.209 False True IGHV3 IGKV3 Kappa None None None None None 8gf2 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/23/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.851 X-RAY DIFFRACTION 0.252 0.209 False True IGHV5 IGKV4 Kappa None None None None None 8gf2 E F 0 B protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/23/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.851 X-RAY DIFFRACTION 0.252 0.209 False True IGHV3 IGKV3 Kappa None None None None None 8gf2 X Y 0 B protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/23/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.851 X-RAY DIFFRACTION 0.252 0.209 False True IGHV5 IGKV4 Kappa None None None None None 8juh A a 0 NA NA NA NA IMMUNE SYSTEM 08/23/23 Crystal structure of ScFv against the receptor binding domine of SARS-CoV-2 S-spike protein Ovis aries ovis aries Ma, Q.Q., Su, Z.D. 2.21 X-RAY DIFFRACTION 0.310 0.257 True True unknown unknown unknown None None None None None 8juh C c 0 NA NA NA NA IMMUNE SYSTEM 08/23/23 Crystal structure of ScFv against the receptor binding domine of SARS-CoV-2 S-spike protein Ovis aries ovis aries Ma, Q.Q., Su, Z.D. 2.21 X-RAY DIFFRACTION 0.310 0.257 True True unknown unknown unknown None None None None None 8gpi A C 0 Z | T protein | protein NA | NA x18 ufo gp41 | x18 ufo gp41 VIRAL PROTEIN 01/08/09 HIV-1 Env X18 UFO in complex with 8ANC195 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Niu, J., Xu, Y.W., Yang, B. 3.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8gpi D E 0 X | R protein | protein NA | NA x18 ufo gp41 | x18 ufo gp41 VIRAL PROTEIN 01/08/09 HIV-1 Env X18 UFO in complex with 8ANC195 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Niu, J., Xu, Y.W., Yang, B. 3.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8gpi H L 0 Y | S protein | protein NA | NA x18 ufo gp41 | x18 ufo gp41 VIRAL PROTEIN 01/08/09 HIV-1 Env X18 UFO in complex with 8ANC195 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Niu, J., Xu, Y.W., Yang, B. 3.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8gpj A C 0 Z | W protein | protein NA | NA x16 ufo gp41 | x16 ufo gp41 VIRAL PROTEIN 08/09/23 HIV-1 Env X16 UFO in complex with 8ANC195 Fab Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Niu, J., Xu, Y.W., Yang, B. 3.5 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8gpj D E 0 X | V protein | protein NA | NA x16 ufo gp41 | x16 ufo gp41 VIRAL PROTEIN 08/09/23 HIV-1 Env X16 UFO in complex with 8ANC195 Fab Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Niu, J., Xu, Y.W., Yang, B. 3.5 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8gpj H L 0 Y | U protein | protein NA | NA x16 ufo gp41 | x16 ufo gp41 VIRAL PROTEIN 08/09/23 HIV-1 Env X16 UFO in complex with 8ANC195 Fab Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Niu, J., Xu, Y.W., Yang, B. 3.5 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8tco E D 0 B | A protein | protein NA | NA envelope glycoprotein l | envelope glycoprotein h VIRAL PROTEIN/IMMUNE SYSTEM 08/09/23 HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 | human betaherpesvirus 5 Goldsmith, J.G., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8tco F G 0 C protein NA envelope glycoprotein o VIRAL PROTEIN/IMMUNE SYSTEM 08/09/23 HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Goldsmith, J.G., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8tea H G 0 C protein NA envelope protein ul128 VIRAL PROTEIN 08/09/23 HCMV Pentamer in complex with CS2pt1p2_A10L Fab and CS3pt1p4_C1L Fab Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Goldsmith, J.G., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8tea F I 0 C | D protein | protein NA | NA envelope protein ul128 | envelope glycoprotein ul130 VIRAL PROTEIN 08/09/23 HCMV Pentamer in complex with CS2pt1p2_A10L Fab and CS3pt1p4_C1L Fab Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 | human betaherpesvirus 5 Goldsmith, J.G., McLellan, J.S. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8ahl E NA 0 D protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ahl F NA 0 C | H | A protein | protein | protein NA | NA | NA crescentin | crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ahl K NA 0 J protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ahl L NA 0 I | G protein | protein NA | NA crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aia D NA 0 B | K protein | protein NA | NA crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 5.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aia J NA 0 N protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aia C NA 0 A protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aia I NA 0 M protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C1 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix D NA 0 B | K protein | protein NA | NA crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix J NA 0 N protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix C NA 0 A protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix I NA 0 M protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix P NA 0 F | U protein | protein NA | NA crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix T NA 0 X protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix O NA 0 E protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8aix S NA 0 W protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 5.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb E NA 0 D protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb F NA 0 C | H | A protein | protein | protein NA | NA | NA crescentin | crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb K NA 0 J protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb L NA 0 I | G protein | protein NA | NA crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb Q NA 0 P protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb R NA 0 O | M | T protein | protein | protein NA | NA | NA crescentin | crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb W NA 0 V protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8ajb X NA 0 U | S protein | protein NA | NA crescentin | crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides | caulobacter vibrioides Liu, Y., Lowe, J. 4.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7t9t C D 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with complex glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.7 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7t9t G H 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with complex glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.7 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7t9t K L 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with complex glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.7 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7yix C c 0 A protein NA alkaline phosphatase, tissue-nonspecific isozyme HYDROLASE 08/16/23 The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex. Homo sapiens homo sapiens homo sapiens Yu, Y.T., Yao, D.Q., Zhang, Q., Rao, B., Xia, Y., Lu, Y., Qin, A., Ma, P.X., Cao, Y. 2.96 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yix D d 0 B protein NA alkaline phosphatase, tissue-nonspecific isozyme HYDROLASE 08/16/23 The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex. Homo sapiens homo sapiens homo sapiens Yu, Y.T., Yao, D.Q., Zhang, Q., Rao, B., Xia, Y., Lu, Y., Qin, A., Ma, P.X., Cao, Y. 2.96 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yrn D E 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cyro-EM structure of HCMV glycoprotein B in complex with 1B03 Fab Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Wang, H., Zhu, S., Liao, H. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7yrn F G 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cyro-EM structure of HCMV glycoprotein B in complex with 1B03 Fab Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Wang, H., Zhu, S., Liao, H. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7yrn H I 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cyro-EM structure of HCMV glycoprotein B in complex with 1B03 Fab Homo sapiens; Human betaherpesvirus 5 homo sapiens homo sapiens human betaherpesvirus 5 Wang, H., Zhu, S., Liao, H. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 8a95 R O 0 A protein NA sars-cov2 trimeric spike in 1-up conformation in complexwith three fab47 VIRAL PROTEIN 01/08/09 SARS Cov2 Spike RBD in complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Hallberg, B.M., Das, H. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8a95 S P 0 B protein NA sars-cov2 trimeric spike in 1-up conformation in complexwith three fab47 VIRAL PROTEIN 01/08/09 SARS Cov2 Spike RBD in complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Hallberg, B.M., Das, H. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8a95 T Q 0 C protein NA sars-cov2 trimeric spike in 1-up conformation in complexwith three fab47 VIRAL PROTEIN 01/08/09 SARS Cov2 Spike RBD in complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Hallberg, B.M., Das, H. 2.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8afe D NA 0 B protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afe C NA 0 A protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afe I NA 0 G peptide NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afe J NA 0 H peptide NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh D NA 0 B protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh C NA 0 A protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh I NA 0 G peptide NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh J NA 0 H peptide NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh N NA 0 L protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh M NA 0 K protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh S NA 0 Q peptide NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afh T NA 0 R peptide NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 3.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afl D NA 0 B protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C1 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afl C NA 0 A protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C1 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afm D NA 0 B protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afm C NA 0 A protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afm J NA 0 H protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8afm I NA 0 G protein NA crescentin STRUCTURAL PROTEIN 08/16/23 Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and small box) Camelidae; Caulobacter vibrioides camelidae caulobacter vibrioides Liu, Y., Lowe, J. 4.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8dzw H L 0 C protein NA rsv fusion protein STRUCTURAL PROTEIN 01/08/09 RSV F trimer bound to RSV-199 Fab Homo sapiens; Human respiratory syncytial virus A2 homo sapiens homo sapiens human respiratory syncytial virus a2 Wen, X., Jardetzky, T.S. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dzw I M 0 A protein NA rsv fusion protein STRUCTURAL PROTEIN 01/08/09 RSV F trimer bound to RSV-199 Fab Homo sapiens; Human respiratory syncytial virus A2 homo sapiens homo sapiens human respiratory syncytial virus a2 Wen, X., Jardetzky, T.S. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dzw J N 0 B protein NA rsv fusion protein STRUCTURAL PROTEIN 01/08/09 RSV F trimer bound to RSV-199 Fab Homo sapiens; Human respiratory syncytial virus A2 homo sapiens homo sapiens human respiratory syncytial virus a2 Wen, X., Jardetzky, T.S. 2.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8e2u H L 0 A protein NA fusion glycoprotein f0 BIOSYNTHETIC PROTEIN 08/16/23 HMPV F monomer bound to RSV-199 Fab Homo sapiens; Human metapneumovirus A homo sapiens homo sapiens human metapneumovirus a Wen, X., Jardetzky, T.S. 3.48 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8eay H L 0 A protein NA fusion glycoprotein f0 BIOSYNTHETIC PROTEIN 08/16/23 HMPV F complex with 4I3 Fab Homo sapiens; Human metapneumovirus A homo sapiens homo sapiens human metapneumovirus a Wen, X., Jardetzky, T.S. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 8ebp H L 0 A protein NA fusion glycoprotein f0 BIOSYNTHETIC PROTEIN 08/16/23 HMPV F dimer bound to RSV-199 Fab Homo sapiens; Human metapneumovirus A homo sapiens homo sapiens human metapneumovirus a Wen, X., Jardetzky, T.S. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8ebp I M 0 B protein NA fusion glycoprotein f0 BIOSYNTHETIC PROTEIN 08/16/23 HMPV F dimer bound to RSV-199 Fab Homo sapiens; Human metapneumovirus A homo sapiens homo sapiens human metapneumovirus a Wen, X., Jardetzky, T.S. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8ezk H h 0 A protein NA 25 kda ookinete surface antigen IMMUNE SYSTEM 08/16/23 Pfs25 in complex with transmission-reducing antibody AS01-04 Homo sapiens; Plasmodium falciparum (isolate NF54) homo sapiens plasmodium falciparum (isolate nf54) Shukla, N., Tang, W.K., Tolia, N.H. 2.3 X-RAY DIFFRACTION 0.260 0.229 True True unknown unknown unknown None None None None None 8ezk I i 0 B protein NA 25 kda ookinete surface antigen IMMUNE SYSTEM 08/16/23 Pfs25 in complex with transmission-reducing antibody AS01-04 Homo sapiens; Plasmodium falciparum (isolate NF54) homo sapiens plasmodium falciparum (isolate nf54) Shukla, N., Tang, W.K., Tolia, N.H. 2.3 X-RAY DIFFRACTION 0.260 0.229 True True unknown unknown unknown None None None None None 8ezl H h 0 A protein NA 25 kda ookinete surface antigen IMMUNE SYSTEM 08/16/23 Pfs25 in complex with transmission-reducing antibody AS01-50 Plasmodium falciparum NF54 plasmodium falciparum nf54 plasmodium falciparum nf54 Shukla, N., Tang, W.K., Tolia, N.H. 2.3 X-RAY DIFFRACTION 0.255 0.216 True True unknown unknown unknown None None None None None 8ezm H h 0 A protein NA 25 kda ookinete surface antigen IMMUNE SYSTEM 08/16/23 Pfs25 in complex with transmission-reducing antibody AS01-63 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Shukla, N., Tang, W.K., Tolia, N.H. 2.1 X-RAY DIFFRACTION 0.237 0.205 True True unknown unknown unknown None None None None None 8hr2 B NA 0 A protein NA spike protein s1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/16/23 Ternary Crystal Complex Structure of RBD with NB1B5 and NB1C6 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Sun, Z. 1.94 X-RAY DIFFRACTION 0.222 0.191 False True IGHV1 NA NA None None None None None 8hr2 C NA 0 A protein NA spike protein s1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/16/23 Ternary Crystal Complex Structure of RBD with NB1B5 and NB1C6 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Sun, Z. 1.94 X-RAY DIFFRACTION 0.222 0.191 False True IGHV1 NA NA None None None None None 8iv4 H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 3E2 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.59 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 8iv4 A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 3E2 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.59 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 8iv5 H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.77 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 8iv5 A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.77 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 8iv8 H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 3E2 and 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.92 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 8iv8 C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 3E2 and 1C4 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.92 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV5 Kappa None None None None None 8iva C E 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs XMA01 and 3E2 (local refinement) Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8iva H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/16/23 Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs XMA01 and 3E2 (local refinement) Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Jiang, Y., Zheng, Q., Li, S., Xia, N. 3.95 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 8iy5 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PEPTIDE BINDING PROTEIN 08/16/23 ETB-Gi complex bound to endothelin-1 Bos taurus; Homo sapiens; Mus musculus; Rattus rattus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | rattus rattus Sano, F.K., Akasaka, H., Shihoya, W., Nureki, O. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8sh5 H L 0 R nucleic-acid NA rna (88-mer) RNA/IMMUNE SYSTEM 08/16/23 Crystal structure of 3'cap-independent translation enhancers (CITE) from Pea enation mosaic virus RNA 2 (PEMV2) with Fab BL3-6K170A Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus pea enation mosaic virus 2 Lewicka, A., Roman, C., Rice, P.A., Piccirilli, J.A. 2.75 X-RAY DIFFRACTION 0.297 0.251 False True IGHV3 IGKV1 Kappa None None None None None 8sk5 B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 08/16/23 Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Noland, C.L., Pande, K., Zhang, L., Zhou, H., Galli, J., Eddins, M., Gomez-Llorente, Y. 2.011 X-RAY DIFFRACTION 0.211 0.183 False True IGHV1 NA NA None None None None None 8tfp B A 0 B Hapten 84K methyl 1-(2-phenylethyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate IMMUNE SYSTEM 08/16/23 Fab from C10-S66K antibody in complex with carfentanil Homo sapiens homo sapiens homo sapiens homo sapiens Pholcharee, T., Wilson, I.A. 1.78 X-RAY DIFFRACTION 0.207 0.178 False True IGHV4 IGLV3 Lambda None None None None None 8tfp H L 0 H Hapten 84K methyl 1-(2-phenylethyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate IMMUNE SYSTEM 08/16/23 Fab from C10-S66K antibody in complex with carfentanil Homo sapiens homo sapiens homo sapiens homo sapiens Pholcharee, T., Wilson, I.A. 1.78 X-RAY DIFFRACTION 0.207 0.178 False True IGHV4 IGLV3 Lambda None None None None None 8tfq B A 0 B Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 08/16/23 Fab from C10-S66K antibody in complex with fentanyl Homo sapiens homo sapiens homo sapiens homo sapiens Pholcharee, T., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.216 0.178 False True IGHV4 IGLV3 Lambda None None None None None 8tfq H L 0 H Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 08/16/23 Fab from C10-S66K antibody in complex with fentanyl Homo sapiens homo sapiens homo sapiens homo sapiens Pholcharee, T., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.216 0.178 False True IGHV4 IGLV3 Lambda None None None None None 8tfr A B 0 NA NA NA NA IMMUNE SYSTEM 08/16/23 Apo Fab from C10-S66K antibody Homo sapiens; Streptococcus sp. group G homo sapiens homo sapiens Pholcharee, T., Wilson, I.A. 2.99 X-RAY DIFFRACTION 0.262 0.211 False True IGHV4 IGLV3 Lambda None None None None None 8thk F f 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/16/23 Cryo-EM structure of A61603-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein Enterobacteria phage T4; Homo sapiens homo sapiens homo sapiens | homo sapiens Su, M., Huang, X.Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8thl F f 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/16/23 Cryo-EM structure of epinephrine-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein Enterobacteria phage T4; Homo sapiens homo sapiens homo sapiens | homo sapiens Su, M., Huang, X.Y. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yk4 H L 0 A protein NA tumor necrosis factor receptor superfamily member 4 ANTITUMOR PROTEIN/IMMUNE SYSTEM 08/09/23 ox40-antibody Homo sapiens homo sapiens homo sapiens homo sapiens Zhou, A. 2.7 X-RAY DIFFRACTION 0.299 0.233 False True IGHV1 IGKV1 Kappa None None None None None 7yk4 I M 0 B protein NA tumor necrosis factor receptor superfamily member 4 ANTITUMOR PROTEIN/IMMUNE SYSTEM 08/09/23 ox40-antibody Homo sapiens homo sapiens homo sapiens homo sapiens Zhou, A. 2.7 X-RAY DIFFRACTION 0.299 0.233 False True IGHV1 IGKV1 Kappa None None None None None 8axh H h 0 A peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/09/23 Crystal structure of a MUC1-like glycopeptide containing the unnatural L-4-hydroxynorvaline in complex with scFv-SM3 Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens Bermejo, I., Corzana, F., Hurtado-Guerrero, R. 1.85 X-RAY DIFFRACTION 0.206 0.167 True True unknown unknown unknown None None None None None 8b17 B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AWA Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.5 X-RAY DIFFRACTION 0.269 0.235 False True IGHV1 NA NA None None None None None 8b18 B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AF Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.3 X-RAY DIFFRACTION 0.254 0.227 False True IGHV1 NA NA None None None None None 8b19 B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AFA Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.45 X-RAY DIFFRACTION 0.268 0.224 False True IGHV1 NA NA None None None None None 8b1a B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AI Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.15 X-RAY DIFFRACTION 0.239 0.215 False True IGHV1 NA NA None None None None None 8b1b B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AL Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.8 X-RAY DIFFRACTION 0.263 0.226 False True IGHV1 NA NA None None None None None 8b1c B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-ALA Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.56 X-RAY DIFFRACTION 0.241 0.215 False True IGHV1 NA NA None None None None None 8b1d B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-APF Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.3 X-RAY DIFFRACTION 0.258 0.230 False True IGHV1 NA NA None None None None None 8b1e B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AQ Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.47 X-RAY DIFFRACTION 0.268 0.223 False True IGHV1 NA NA None None None None None 8b1f B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AV Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.35 X-RAY DIFFRACTION 0.237 0.217 False True IGHV1 NA NA None None None None None 8b1g B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-AW Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.5 X-RAY DIFFRACTION 0.249 0.225 False True IGHV1 NA NA None None None None None 8b1h B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-KV Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.6 X-RAY DIFFRACTION 0.260 0.226 False True IGHV1 NA NA None None None None None 8b1i B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-MS Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.55 X-RAY DIFFRACTION 0.258 0.224 False True IGHV1 NA NA None None None None None 8b1j B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-SL Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.67 X-RAY DIFFRACTION 0.264 0.222 False True IGHV1 NA NA None None None None None 8b1k B NA 0 A protein NA dipeptide and tripeptide permease b MEMBRANE PROTEIN 08/09/23 DtpB-Nb132-NV Escherichia coli; Lama glama; SYNTHETIC CONSTRUCT lama glama escherichia coli Killer, M., Finocchio, G., Lei, J., Jungnickel, K., Kotov, V., Steinke, J., Bartels, K., Strauss, J., Dupeux, F., Humm, A.S., Cornaciu, I., Marquez, J., Pardon, E., Steyeart, J., Loew, C. 2.8 X-RAY DIFFRACTION 0.250 0.226 False True IGHV1 NA NA None None None None None 8cge A a 0 NA NA NA NA METAL BINDING PROTEIN 08/09/23 The crystal structure of a cobalt-bound scFv reveals a Tetrameric polyHistidine motif (TetrHis) synthetic construct synthetic construct Healey, R.D., Hoh, F., Granier, S., Leyrat, C. 2.5 X-RAY DIFFRACTION 0.248 0.190 True True unknown unknown unknown None None None None None 8cge B b 0 NA NA NA NA METAL BINDING PROTEIN 08/09/23 The crystal structure of a cobalt-bound scFv reveals a Tetrameric polyHistidine motif (TetrHis) synthetic construct synthetic construct Healey, R.D., Hoh, F., Granier, S., Leyrat, C. 2.5 X-RAY DIFFRACTION 0.248 0.190 True True unknown unknown unknown None None None None None 8e6j H L 0 A protein NA neuraminidase VIRAL PROTEIN 08/09/23 3H03 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8e6j E I 0 B protein NA neuraminidase VIRAL PROTEIN 08/09/23 3H03 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8e6j F J 0 C protein NA neuraminidase VIRAL PROTEIN 08/09/23 3H03 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8e6j G K 0 D protein NA neuraminidase VIRAL PROTEIN 08/09/23 3H03 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8e6k H L 0 A protein NA neuraminidase VIRAL PROTEIN 08/09/23 2H08 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8e6k E I 0 B protein NA neuraminidase VIRAL PROTEIN 08/09/23 2H08 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8e6k F J 0 C protein NA neuraminidase VIRAL PROTEIN 08/09/23 2H08 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8e6k G K 0 D protein NA neuraminidase VIRAL PROTEIN 08/09/23 2H08 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) Homo sapiens; Influenza A virus (A/Brevig Mission/1/1918(H1N1)) homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) Turner, H.L., Ozorowski, G., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8eqa H L 0 NA NA NA NA IMMUNE SYSTEM 08/09/23 Crystal structure of human anti-N1 neuraminidase 2H08 Fab Homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 2.55 X-RAY DIFFRACTION 0.264 0.215 False True IGHV4 IGKV1 Kappa None None None None None 8eqa B A 0 NA NA NA NA IMMUNE SYSTEM 08/09/23 Crystal structure of human anti-N1 neuraminidase 2H08 Fab Homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 2.55 X-RAY DIFFRACTION 0.264 0.215 False True IGHV4 IGKV1 Kappa None None None None None 8eqc H L 0 NA NA NA NA IMMUNE SYSTEM 08/09/23 Crystal structure of human anti-N1 neuraminidase 3H03 Fab Homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.217 0.179 False True IGHV4 IGKV1 Kappa None None None None None 8eqc B A 0 NA NA NA NA IMMUNE SYSTEM 08/09/23 Crystal structure of human anti-N1 neuraminidase 3H03 Fab Homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.217 0.179 False True IGHV4 IGKV1 Kappa None None None None None 8gp5 E F 0 X protein NA x18 ufo env protomer VIRAL PROTEIN 08/09/23 Structure of X18 UFO protomer in complex with F6 Fab VHVL domain Homo sapiens homo sapiens homo sapiens homo sapiens Niu, J., Xu, Y.W., Yang, B. 4.05 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8gpg A B 0 Z protein NA hiv-1 env x18 ufo VIRAL PROTEIN 08/09/23 HIV-1 Env X18 UFO in complex with F6 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Niu, J., Xu, Y.W., Yang, B. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8gpg C D 0 Y protein NA hiv-1 env x18 ufo VIRAL PROTEIN 08/09/23 HIV-1 Env X18 UFO in complex with F6 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Niu, J., Xu, Y.W., Yang, B. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8gpg E F 0 X protein NA hiv-1 env x18 ufo VIRAL PROTEIN 08/09/23 HIV-1 Env X18 UFO in complex with F6 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Niu, J., Xu, Y.W., Yang, B. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8gpk A B 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Crystal structure of human anti-HIV-1 broadly neutralizing antibody F6 Fab Homo sapiens homo sapiens homo sapiens Niu, J., Yang, B. 3.34 X-RAY DIFFRACTION 0.281 0.242 False True IGHV4 IGKV2 Kappa None None None None None 8gpk C D 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 Crystal structure of human anti-HIV-1 broadly neutralizing antibody F6 Fab Homo sapiens homo sapiens homo sapiens Niu, J., Yang, B. 3.34 X-RAY DIFFRACTION 0.281 0.242 False True IGHV4 IGKV2 Kappa None None None None None 8h0p E e 0 A | B protein | protein NA | NA g-alpha q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/09/23 Structure of the NMB30-NMBR and Gq complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Li, C., Xu, Y., Liu, H., Cai, H., Xu, H.E., Yin, W. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8h0q E e 0 A | B protein | protein NA | NA g-alpha q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/09/23 Structure of the GRP14-27-GRPR-Gq complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Li, C., Xu, Y., Liu, H., Cai, H., Xu, H.E., Yin, W. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8pm2 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/09/23 Structure of the murine trace amine-associated receptor TAAR7f bound to N,N-dimethylcyclohexylamine (DMCH) in complex with mini-Gs trimeric G protein Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Gusach, A., Lee, Y., Edwards, P.C., Huang, F., Weyand, S.N., Tate, C.G. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8h3c A a 0 NA NA NA NA ANTIVIRAL PROTEIN 08/02/23 Crystal structure of M2e Influenza peptide in complex with antibody scFv Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 3.43 X-RAY DIFFRACTION 0.235 0.204 True True unknown unknown unknown None None None None None 8h3c B b 0 F | G peptide | peptide NA | NA matrix protein 2 | matrix protein 2 ANTIVIRAL PROTEIN 08/02/23 Crystal structure of M2e Influenza peptide in complex with antibody scFv Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens influenza a virus | influenza a virus Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 3.43 X-RAY DIFFRACTION 0.235 0.204 True True unknown unknown unknown None None None None None 8h3c C c 0 NA NA NA NA ANTIVIRAL PROTEIN 08/02/23 Crystal structure of M2e Influenza peptide in complex with antibody scFv Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 3.43 X-RAY DIFFRACTION 0.235 0.204 True True unknown unknown unknown None None None None None 8h3c D d 0 F peptide NA matrix protein 2 ANTIVIRAL PROTEIN 08/02/23 Crystal structure of M2e Influenza peptide in complex with antibody scFv Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens influenza a virus Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 3.43 X-RAY DIFFRACTION 0.235 0.204 True True unknown unknown unknown None None None None None 8h3c E e 0 NA NA NA NA ANTIVIRAL PROTEIN 08/02/23 Crystal structure of M2e Influenza peptide in complex with antibody scFv Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 3.43 X-RAY DIFFRACTION 0.235 0.204 True True unknown unknown unknown None None None None None 7tcn C D 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN 08/02/23 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with high-mannose glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Henderson, R., Acharya, P. 4.1 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7tcn G H 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN 08/02/23 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with high-mannose glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Henderson, R., Acharya, P. 4.1 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7tcn K L 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN 08/02/23 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with high-mannose glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Henderson, R., Acharya, P. 4.1 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7tco C D 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN 08/02/23 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 with high-mannose glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Henderson, R., Acharya, P. 4.19 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7tco G H 0 E protein NA envelope glycoprotein gp120 VIRAL PROTEIN 08/02/23 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 with high-mannose glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Henderson, R., Acharya, P. 4.19 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7tco O P 0 M protein NA envelope glycoprotein gp120 VIRAL PROTEIN 08/02/23 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 with high-mannose glycans Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Henderson, R., Acharya, P. 4.19 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7trh H B 0 G protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 08/02/23 Human antibody K03.28 in complex with the influenza hemagglutinin head domain of A/California/07/2009(H1N1)(X-181) Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus McCarthy, K.R. 3 X-RAY DIFFRACTION 0.242 0.202 False True IGHV3 IGLV3 Lambda None None None None None 7tri Z Y 0 B protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 08/02/23 Human antibody S8V1-172 in complex with the influenza hemagglutinin head domain of A/Sydney/05/1997(H3N2) Homo sapiens; Influenza A virus (A/Sydney/5/1997(H3N2)) homo sapiens homo sapiens influenza a virus (a/sydney/5/1997(h3n2)) McCarthy, K.R. 3.6 X-RAY DIFFRACTION 0.268 0.233 False True IGHV4 IGKV3 Kappa None None None None None 7y71 O P 0 A | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 08/02/23 SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Chia, W.N., Tan, C.W., Tan, A.W.K., Young, B., Starr, T.N., Lopez, E., Fibriansah, G., Barr, J., Cheng, S., Yeoh, A.Y.Y., Yap, W.C., Lim, B.L., Ng, T.S., Sia, W.R., Zhu, F., Chen, S., Zhang, J., Greaney, A.J., Chen, M., Au, G.G., Paradkar, P., Peiris, M., Chung, A.W., Bloom, J.D., Lye, D., Lok, S.M., Wang, L.F. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 7y72 O P 0 A | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 08/02/23 SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 (focused refinement on Fab-RBD interface) Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Chia, W.N., Tan, C.W., Tan, A.W.K., Young, B., Starr, T.N., Lopez, E., Fibriansah, G., Barr, J., Cheng, S., Yeoh, A.Y.Y., Yap, W.C., Lim, B.L., Ng, T.S., Sia, W.R., Zhu, F., Chen, S., Zhang, J., Greaney, A.J., Chen, M., Au, G.G., Paradkar, P., Peiris, M., Chung, A.W., Bloom, J.D., Lye, D., Lok, S.M., Wang, L.F. 4.03 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 7yiz B A 0 B Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 08/02/23 Crystal structure of anti-mPEG h15-2b Fab W104Y mutant Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Li, Y.C., Su, Y.C. 2.42 X-RAY DIFFRACTION 0.270 0.216 False True IGHV3 IGKV1 Kappa None None None None None 7yiz D C 0 D Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 08/02/23 Crystal structure of anti-mPEG h15-2b Fab W104Y mutant Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Li, Y.C., Su, Y.C. 2.42 X-RAY DIFFRACTION 0.270 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8aon B C 0 A protein NA unknown IMMUNE SYSTEM 01/08/09 Oxidoreductase fragment of human QSOX1 in complex with a Fab fragment of a humanized anti-QSOX1 antibody Homo sapiens homo sapiens homo sapiens Khmelnitsky, L., Fass, D. 2.1 X-RAY DIFFRACTION 0.259 0.198 False True IGHV3 IGKV4 Kappa None None None None None 8c5h N NA 0 S protein NA synaptotagmin-1 METAL BINDING PROTEIN 08/02/23 NbSyt1 anti-(rat Synaptotagmin-1) nanobody bound to target cytosolic domain of Synaptotagmin-1 Rattus norvegicus; Vicugna pacos vicugna pacos rattus norvegicus Martinez-Carranza, M., Stenmark, P. 1.68 X-RAY DIFFRACTION 0.222 0.209 False True IGHV3 NA NA None None None None None 8dpz F G 0 B protein NA spike protein s1 VIRAL PROTEIN/Immune System 08/02/23 Local refinement of SARS-CoV-2 vaccine induced antibody DH1338 bound to SARS-CoV-2 HexaPro RBD Spike ectodomain Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Stalls, V., May, A.J., Acharya, P. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8dtk C B 0 A protein NA spike protein s1 Viral Protein/Immune System 08/02/23 Structure of RBD directed antibody DH1047 in complex with SARS-CoV-2 spike: Local refinement of RBD-Fab interace Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 May, A.J., Manne, K., Acharya, P. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8dyt H L 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyt A B 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyt C D 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyt E F 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyt M N 0 J peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyt O P 0 J peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyt Q R 0 J peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyt S T 0 J peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 227 Fab in complex with (NPNA)8 peptide Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Martin, G.M., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyw H L 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw A B 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw C D 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw E F 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw M N 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw O P 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw Q R 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw S T 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw U V 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyw W X 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyx H L 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx A B 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx C D 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx E F 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx M N 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx O P 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx Q R 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx S T 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx U V 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx W X 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyx Y Z 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 311 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dyy H L 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy A B 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy C D 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy E F 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy M N 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy O P 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy Q R 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy S T 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dyy U V 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dz3 H L 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz3 A B 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz3 C D 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz3 E F 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz3 M N 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz3 O P 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz3 Q R 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 H L 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 A B 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 C D 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 E F 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 M N 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 O P 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 Q R 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 S T 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 U V 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 W X 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz4 Y Z 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dz5 H L 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 364 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dz5 A B 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 364 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dz5 C D 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 364 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dz5 E F 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 364 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dz5 M N 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 08/02/23 Cryo-EM structure of 364 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Martin, G.M., Ward, A.B. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f0j N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 08/02/23 Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45 Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cao, J., Sexton, P.M., Wootten, D.L., Belousoff, M.J. 2.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8f0k N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 08/02/23 Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cao, J., Sexton, P.M., Wootten, D.L. 1.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8f2a N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 08/02/23 Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation) Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Sexton, P.M., Wootten, D.L., Radostin, D. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8f2b N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 08/02/23 Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45 Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cao, J., Sexton, P.M., Wootten, D.L., Belousoff, M.J. 2.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8f6x D d 0 B protein NA structurally designed hmpv f protein hmpv_v3b_d12_ds454,fibritin VIRAL PROTEIN/IMMUNE SYSTEM 08/02/23 cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8 Escherichia phage T2; Homo sapiens; Human metapneumovirus homo sapiens human metapneumovirus, escherichia phage t2 Zhou, T., Kwong, P.D., Morano, N.C., Ou, L. 3.25 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8f6x E e 0 C protein NA structurally designed hmpv f protein hmpv_v3b_d12_ds454,fibritin VIRAL PROTEIN/IMMUNE SYSTEM 08/02/23 cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8 Escherichia phage T2; Homo sapiens; Human metapneumovirus homo sapiens human metapneumovirus, escherichia phage t2 Zhou, T., Kwong, P.D., Morano, N.C., Ou, L. 3.25 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8f6x F f 0 A protein NA structurally designed hmpv f protein hmpv_v3b_d12_ds454,fibritin VIRAL PROTEIN/IMMUNE SYSTEM 08/02/23 cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8 Escherichia phage T2; Homo sapiens; Human metapneumovirus homo sapiens human metapneumovirus, escherichia phage t2 Zhou, T., Kwong, P.D., Morano, N.C., Ou, L. 3.25 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ghr C NA 0 A protein NA ectonucleotide pyrophosphatase/phosphodiesterase familymember 1, secreted form, immunoglobulin gamma-1 heavy chain fusion IMMUNE SYSTEM 08/02/23 Structure of human ENPP1 in complex with variable heavy domain VH27.2 Homo sapiens homo sapiens homo sapiens Carozza, J.A., Wang, H., Solomon, P.E., Wells, J.A., Li, L. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8ghr D NA 0 B protein NA ectonucleotide pyrophosphatase/phosphodiesterase familymember 1, secreted form, immunoglobulin gamma-1 heavy chain fusion IMMUNE SYSTEM 08/02/23 Structure of human ENPP1 in complex with variable heavy domain VH27.2 Homo sapiens homo sapiens homo sapiens Carozza, J.A., Wang, H., Solomon, P.E., Wells, J.A., Li, L. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8h3b A a 0 NA NA NA NA ANTIVIRAL PROTEIN 08/02/23 Crystal structure of antibody scFv against M2e Influenza peptide Homo sapiens homo sapiens Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 2.75 X-RAY DIFFRACTION 0.215 0.181 True True unknown unknown unknown None None None None None 8h3b B b 0 NA NA NA NA ANTIVIRAL PROTEIN 08/02/23 Crystal structure of antibody scFv against M2e Influenza peptide Homo sapiens homo sapiens Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 2.75 X-RAY DIFFRACTION 0.215 0.181 True True unknown unknown unknown None None None None None 8h73 D d 0 NA NA NA NA ANTIVIRAL PROTEIN 08/02/23 Crystal structure of antibody scFv against M2e Influenza peptide Homo sapiens homo sapiens Kumar, U., Madni, Z.K., Gaur, V., Salunke, D.M. 1.91 X-RAY DIFFRACTION 0.201 0.180 True True unknown unknown unknown None None None None None 8jr9 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/02/23 Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, L., He, Q., Yuan, Q., Gu, Y., He, X., Shan, H., Li, J., Wang, K., Li, Y., Hu, W., Wu, K., Shen, J., Xu, H.E. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2ybr A B 0 C protein NA beta-mammal toxin cn2 IMMUNE SYSTEM/TOXIN 04/13/11 Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann CENTRUROIDES NOXIUS HOFFMANN; HOMO SAPIENS homo sapiens homo sapiens centruroides noxius hoffmann Canul-Tec, J.C., Riano-Umbarila, L., Rudino-Pinera, E., Becerril, B., Possani, L.D., Torres-Larios, A. 2.55 X-RAY DIFFRACTION 0.24673 0.19183 True True IGHV3 IGKV3 Kappa None None None None None 2ybr D E 0 F protein NA beta-mammal toxin cn2 IMMUNE SYSTEM/TOXIN 04/13/11 Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann CENTRUROIDES NOXIUS HOFFMANN; HOMO SAPIENS homo sapiens homo sapiens centruroides noxius hoffmann Canul-Tec, J.C., Riano-Umbarila, L., Rudino-Pinera, E., Becerril, B., Possani, L.D., Torres-Larios, A. 2.55 X-RAY DIFFRACTION 0.24673 0.19183 True True IGHV3 IGKV3 Kappa None None None None None 2ybr G H 0 I protein NA beta-mammal toxin cn2 IMMUNE SYSTEM/TOXIN 04/13/11 Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann CENTRUROIDES NOXIUS HOFFMANN; HOMO SAPIENS homo sapiens homo sapiens centruroides noxius hoffmann Canul-Tec, J.C., Riano-Umbarila, L., Rudino-Pinera, E., Becerril, B., Possani, L.D., Torres-Larios, A. 2.55 X-RAY DIFFRACTION 0.24673 0.19183 True True IGHV3 IGKV3 Kappa None None None None None 5xj3 A B 0 C protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 04/25/18 Complex structure of ipilimumab-scFv and CTLA-4 Homo sapiens homo sapiens homo sapiens homo sapiens He, M., Chai, Y., Qi, J., Tong, Z., Tan, S., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.264 0.222 True True IGHV3 IGKV3 Kappa None None None None None 5xj3 D E 0 F protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 04/25/18 Complex structure of ipilimumab-scFv and CTLA-4 Homo sapiens homo sapiens homo sapiens homo sapiens He, M., Chai, Y., Qi, J., Tong, Z., Tan, S., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.264 0.222 True True IGHV3 IGKV3 Kappa None None None None None 5xj3 G H 0 I protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 04/25/18 Complex structure of ipilimumab-scFv and CTLA-4 Homo sapiens homo sapiens homo sapiens homo sapiens He, M., Chai, Y., Qi, J., Tong, Z., Tan, S., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.264 0.222 True True IGHV3 IGKV3 Kappa None None None None None 5xj3 J K 0 L protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 04/25/18 Complex structure of ipilimumab-scFv and CTLA-4 Homo sapiens homo sapiens homo sapiens homo sapiens He, M., Chai, Y., Qi, J., Tong, Z., Tan, S., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.264 0.222 True True IGHV3 IGKV3 Kappa None None None None None 5xj4 H L 0 A protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 04/25/18 Complex structure of durvalumab-scFv/PD-L1 Homo sapiens homo sapiens homo sapiens homo sapiens Tan, S., Liu, K., Chai, Y., Gao, G.F., Qi, J. 2.3 X-RAY DIFFRACTION 0.240 0.216 True True IGHV3 IGKV3 Kappa None None None None None 4lar H h 0 h Hapten 1WE (2S)-1-phenylpropan-2-amine IMMUNE SYSTEM 12/11/13 Crystal structure of a therapeutic single chain antibody in complex with amphetamine Mus musculus mus musculus Celical, R., Gokulan, K., Peterson, E.C., Varughese, K.I. 2.38 X-RAY DIFFRACTION 0.293 0.215 True True unknown unknown unknown None None None None None 4ffy H L 0 A protein NA envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 06/20/12 Crystal structure of DENV1-E111 single chain variable fragment bound to DENV-1 DIII, strain 16007. Dengue virus 1; Mus musculus mus musculus mus musculus dengue virus 1 Austin, S.K., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.5 X-RAY DIFFRACTION 0.229 0.174 True True IGHV1 IGKV3 Kappa None None None None None 1mfa H L 0 A carbohydrate MMA O1-METHYL-MANNOSE IMMUNOGLOBULIN 01/31/94 STRUCTURE OF A SINGLE-CHAIN FV FRAGMENT COMPLEXED WITH A CARBOHYDRATE ANTIGEN AT 1.7 ANGSTROMS RESOLUTION Mus musculus mus musculus mus musculus Zdanov, A., Cygler, M. 1.7 X-RAY DIFFRACTION unknown 0.166 True True IGHV1 IGLV1 Lambda None None None None None 7yv1 H L 0 A protein NA isoform 2b of gtpase kras SIGNALING PROTEIN 07/26/23 Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor LUNA18 and KA30L Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Irie, M., Fukami, T.A., Matsuo, A., Saka, K., Nishimura, M., Saito, H., Torizawa, T., Tanada, M., Ohta, A. 1.454 X-RAY DIFFRACTION 0.277 0.238 False True IGHV4 IGKV1 Kappa None None None None None 8dzv A a 0 C peptide NA ctni peptide PROTEIN BINDING 07/26/23 Chicken anti-cardiac Troponin I antibody in complex with peptide Gallus gallus; SYNTHETIC CONSTRUCT gallus gallus homo sapiens Conroy, P.J., Law, H.P. 1.2 X-RAY DIFFRACTION 0.174 0.161 True True unknown unknown unknown None None None None None 8ib1 B A 0 C peptide NA hemagglutinin ha2 chain ANTIVIRAL PROTEIN 07/26/23 Structure of the LAH31 Fab bound to an influenza virus HA epitope peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens influenza a virus Suzuki, T., Hashiguchi, T. 1.95 X-RAY DIFFRACTION 0.225 0.185 False True IGHV1 IGKV2 Kappa None None None None None 8dok C D 0 B protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8dok G H 0 E | F protein | protein NA | NA crf-1_ae t/f100 env gp120 | crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8dok K L 0 J protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8dok M N 0 A protein NA crf-1_ae t/f100 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8dok O P 0 E protein NA crf-1_ae t/f100 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8dok Q R 0 I protein NA crf-1_ae t/f100 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Zhou, F., Huang, R., Tolbert, W., Pazgier, M. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8dwo H L 0 B | A protein | protein NA | NA togavirin | togavirin VIRUS LIKE PARTICLE 07/19/23 Cryo-EM Structure of Eastern Equine Encephalitis Virus in complex with SKE26 Fab Eastern equine encephalitis virus; Macaca fascicularis macaca fascicularis macaca fascicularis eastern equine encephalitis virus | eastern equine encephalitis virus Pletnev, S., Verardi, R., Roedeger, M., Kwong, P. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV2 Kappa None None None None None 8dwo S T 0 G | F protein | protein NA | NA togavirin | togavirin VIRUS LIKE PARTICLE 07/19/23 Cryo-EM Structure of Eastern Equine Encephalitis Virus in complex with SKE26 Fab Eastern equine encephalitis virus; Macaca fascicularis macaca fascicularis macaca fascicularis eastern equine encephalitis virus | eastern equine encephalitis virus Pletnev, S., Verardi, R., Roedeger, M., Kwong, P. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV2 Kappa None None None None None 8dwo U V 0 K | J protein | protein NA | NA togavirin | togavirin VIRUS LIKE PARTICLE 07/19/23 Cryo-EM Structure of Eastern Equine Encephalitis Virus in complex with SKE26 Fab Eastern equine encephalitis virus; Macaca fascicularis macaca fascicularis macaca fascicularis eastern equine encephalitis virus | eastern equine encephalitis virus Pletnev, S., Verardi, R., Roedeger, M., Kwong, P. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV2 Kappa None None None None None 8eev H L 0 A | G protein | protein NA | NA coat protein | coat protein VIRUS LIKE PARTICLE/IMMUNE SYSTEM 07/19/23 Venezuelan equine encephalitis virus-like particle in complex with Fab SKT-20 Macaca fascicularis; Venezuelan equine encephalitis virus macaca fascicularis macaca fascicularis venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Tsybovsky, Y., Pletnev, S., Verardi, R., Roederer, M., Kwong, P.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8eev S T 0 F | K protein | protein NA | NA coat protein | coat protein VIRUS LIKE PARTICLE/IMMUNE SYSTEM 07/19/23 Venezuelan equine encephalitis virus-like particle in complex with Fab SKT-20 Macaca fascicularis; Venezuelan equine encephalitis virus macaca fascicularis macaca fascicularis venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Tsybovsky, Y., Pletnev, S., Verardi, R., Roederer, M., Kwong, P.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 8eev U V 0 J | B protein | protein NA | NA coat protein | coat protein VIRUS LIKE PARTICLE/IMMUNE SYSTEM 07/19/23 Venezuelan equine encephalitis virus-like particle in complex with Fab SKT-20 Macaca fascicularis; Venezuelan equine encephalitis virus macaca fascicularis macaca fascicularis venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Tsybovsky, Y., Pletnev, S., Verardi, R., Roederer, M., Kwong, P.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 7yds B C 0 A protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 07/19/23 The structure of the bispecific antibody targeted PD-L1 and 4-1BB Homo sapiens homo sapiens homo sapiens homo sapiens Gao, Y., Zhu, M., Liu, W.T., Cheng, L.S., Zhu, Z.L., Niu, L.W. 2.3 X-RAY DIFFRACTION 0.246 0.194 False True IGHV3 IGKV1 Kappa None None None None None 7yh6 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Structure of SARS-CoV-2 spike RBD in complex with neutralizing antibody NIV-8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7yh7 P Q 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 spike in complex with neutralizing antibody NIV-8 (state 2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7yh7 S R 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 spike in complex with neutralizing antibody NIV-8 (state 2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7yh7 V U 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 spike in complex with neutralizing antibody NIV-8 (state 2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Moriyama, S., Anraku, Y., Muranishi, S., Adachi, Y., Kuroda, D., Higuchi, Y., Kotaki, R., Tonouchi, K., Yumoto, K., Suzuki, T., Kita, S., Fukuhara, H., Kuroda, Y., Yamamoto, T., Onodera, T., Fukushi, S., Maeda, K., Nakamura-Uchiyama, F., Hashiguchi, T., Hoshino, A., Maenaka, K., Takahashi, Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8ag1 H L 0 A protein NA tumor necrosis factor receptor superfamily member 4 IMMUNE SYSTEM 07/19/23 Crystal structure of a novel OX40 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Gao, H., Zhou, A. 3.303 X-RAY DIFFRACTION 0.268 0.194 False True IGHV6 IGKV3 Kappa None None None None None 8ag1 h l 0 a protein NA unknown IMMUNE SYSTEM 07/19/23 Crystal structure of a novel OX40 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Gao, H., Zhou, A. 3.303 X-RAY DIFFRACTION 0.268 0.194 False False IGHV6 IGKV3 Kappa None None None None None 8bvr B NA 0 A protein NA solute carrier family 22 member 6 MEMBRANE PROTEIN 07/19/23 Cryo-EM structure of rat SLC22A6 in the apo state Rattus norvegicus; synthetic construct synthetic construct rattus norvegicus Parker, J.L., Kato, T., Newstead, S. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8bvs B NA 0 A protein NA solute carrier family 22 member 6 MEMBRANE PROTEIN 07/19/23 Cryo-EM structure of rat SLC22A6 bound to tenofovir Rattus norvegicus; synthetic construct synthetic construct rattus norvegicus Parker, J.L., Kato, T., Newstead, S. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8bvt B NA 0 A protein NA solute carrier family 22 member 6 MEMBRANE PROTEIN 07/19/23 Cryo-EM structure of rat SLC22A6 bound to probenecid Rattus norvegicus; synthetic construct synthetic construct rattus norvegicus Parker, J.L., Kato, T., Newstead, S. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8bw7 B NA 0 A protein NA solute carrier family 22 member 6 MEMBRANE PROTEIN 07/19/23 Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid Rattus norvegicus; synthetic construct synthetic construct rattus norvegicus Parker, J.L., Kato, T., Newstead, S. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8d0y D E 0 B protein NA bg505sosipv8 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Crystal Structure of HIV-1 BG505 SOSIPv8 Trimer in Complex with CD4bs targeting antibody 21N13 and interface targeting antibody 35O22 at 4.7 Angstrom Macaca mulatta macaca mulatta macaca mulatta macaca mulatta Xian, Y., Wilson, A. 4.7 X-RAY DIFFRACTION 0.298 0.268 False True unknown unknown unknown None None None None None 8d0y H L 0 G protein NA bg505sosipv8 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 Crystal Structure of HIV-1 BG505 SOSIPv8 Trimer in Complex with CD4bs targeting antibody 21N13 and interface targeting antibody 35O22 at 4.7 Angstrom Macaca mulatta macaca mulatta macaca mulatta macaca mulatta Xian, Y., Wilson, A. 4.7 X-RAY DIFFRACTION 0.298 0.268 False True IGHV4 IGKV1 Kappa None None None None None 8dow C D 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 07/19/23 Cryo-EM structure of HIV-1 Env(CH848 10.17 DS.SOSIP_DT) in complex with DH1030.1 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gobeil, S., Acharya, P. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8dow G H 0 E protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 07/19/23 Cryo-EM structure of HIV-1 Env(CH848 10.17 DS.SOSIP_DT) in complex with DH1030.1 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gobeil, S., Acharya, P. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8dow K L 0 I protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 07/19/23 Cryo-EM structure of HIV-1 Env(CH848 10.17 DS.SOSIP_DT) in complex with DH1030.1 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gobeil, S., Acharya, P. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8dp0 B NA 0 A protein NA phosphatidylinositol 4,5-bisphosphate 3-kinase catalyticsubunit gamma isoform TRANSFERASE/IMMUNE SYSTEM 07/19/23 Structure of p110 gamma bound to the Ras inhibitory nanobody NB7 Homo sapiens; Lama glama lama glama homo sapiens Burke, J.E., Nam, S.E., Rathinaswamy, M.K., Yip, C.K. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dp1 R M 0 W protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 01/08/09 Cryo-EM structure of HIV-1 Env(BG505.T332N SOSIP) in complex with DH1030.1 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gobeil, S., Acharya, P. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8dp1 E F 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 01/08/09 Cryo-EM structure of HIV-1 Env(BG505.T332N SOSIP) in complex with DH1030.1 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gobeil, S., Acharya, P. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8dp1 N O 0 J protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 01/08/09 Cryo-EM structure of HIV-1 Env(BG505.T332N SOSIP) in complex with DH1030.1 Fab Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Gobeil, S., Acharya, P. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8dpl H h 0 N protein NA glycoprotein gp2 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 2.53 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpl C c 0 J protein NA glycoprotein gp2 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 2.53 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpl O o 0 E protein NA glycoprotein gp2 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 2.53 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpl F G 0 I protein NA glycoprotein gp1 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus homo sapiens homo sapiens ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 2.53 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dpl A B 0 D protein NA glycoprotein gp1 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus homo sapiens homo sapiens ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 2.53 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dpl K L 0 M protein NA glycoprotein gp1 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus homo sapiens homo sapiens ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 2.53 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dpm H h 0 B protein NA glycoprotein gp2 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpm C c 0 L protein NA glycoprotein gp2 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpm M m 0 G protein NA glycoprotein gp2 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpm I J 0 F protein NA glycoprotein gp1 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus homo sapiens homo sapiens ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dpm D E 0 A protein NA glycoprotein gp1 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus homo sapiens homo sapiens ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dpm N O 0 K protein NA glycoprotein gp1 VIRAL PROTEIN/Immune System 07/19/23 Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound Ebola virus - Mayinga, Zaire, 1976; Homo sapiens; Mus musculus homo sapiens homo sapiens ebola virus - mayinga, zaire, 1976 Yu, X., Saphire, E.O. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8eeu H L 0 A | C | D protein | protein | protein NA | NA | NA coat protein | coat protein | coat protein VIRUS LIKE PARTICLE/IMMUNE SYSTEM 07/19/23 Venezuelan equine encephalitis virus-like particle in complex with Fab SKT05 Macaca fascicularis; Venezuelan equine encephalitis virus macaca fascicularis macaca fascicularis venezuelan equine encephalitis virus | venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Tsybovsky, Y., Pletnev, S., Verardi, R., Roederer, M., Kwong, P.D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8el2 H L 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 RBD bound to neutralizing antibody Fab ICO-hu23 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Besaw, J.E., Kuo, A., Morizumi, T., Ernst, O.P. 2.89 X-RAY DIFFRACTION 0.282 0.239 False True IGHV1 IGLV2 Lambda None None None None None 8el2 I K 0 B protein NA spike protein s1 ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 RBD bound to neutralizing antibody Fab ICO-hu23 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Besaw, J.E., Kuo, A., Morizumi, T., Ernst, O.P. 2.89 X-RAY DIFFRACTION 0.282 0.239 False True IGHV1 IGLV2 Lambda None None None None None 8elj S T 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yee, A.W., Morizumi, T., Kim, K., Kuo, A., Ernst, O.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8elj U V 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yee, A.W., Morizumi, T., Kim, K., Kuo, A., Ernst, O.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8elj W X 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/19/23 SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yee, A.W., Morizumi, T., Kim, K., Kuo, A., Ernst, O.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8fsj H L 0 E protein NA hcv e2 ectodomain, synzip2 scaffold fusion VIRAL PROTEIN 07/19/23 Cryo-EM structure of engineered hepatitis C virus E1E2 ectodomain in complex with antibodies AR4A, HEPC74, and IGH520 Hepacivirus C; Homo sapiens; synthetic construct homo sapiens homo sapiens hepacivirus c, synthetic construct Metcalf, M.C., Ofek, G. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8fsj C B 0 E protein NA hcv e2 ectodomain, synzip2 scaffold fusion VIRAL PROTEIN 07/19/23 Cryo-EM structure of engineered hepatitis C virus E1E2 ectodomain in complex with antibodies AR4A, HEPC74, and IGH520 Hepacivirus C; Homo sapiens; synthetic construct homo sapiens homo sapiens hepacivirus c, synthetic construct Metcalf, M.C., Ofek, G. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8ic0 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/19/23 Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Ishimoto, N., Park, J.H., Park, S.Y. 3.41 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ol9 B A 0 H protein NA coagulation factor ix heavy chain BLOOD CLOTTING 07/19/23 Anti-FIXa Fab in complex with human des-(Gla-EGF1) FIXa Homo sapiens homo sapiens homo sapiens homo sapiens Johansson, E., Svensson, L.A. 2.6 X-RAY DIFFRACTION 0.323 0.267 False True IGHV3 IGKV1 Kappa None None None None None 8omu B NA 0 A protein NA solute carrier family 22 member 6 METAL TRANSPORT 07/19/23 Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state Rattus norvegicus; synthetic construct synthetic construct rattus norvegicus Parker, J.L., Kato, T., Newstead, S. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g4m D E 0 A | C protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 ANTIVIRAL PROTEIN 07/12/23 Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8g4m H L 0 F | I protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 ANTIVIRAL PROTEIN 07/12/23 Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8g4m J K 0 B | G protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 ANTIVIRAL PROTEIN 07/12/23 Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8g4t H L 0 F | I protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 2.81 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8g4t D E 0 A | C protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 2.81 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8g4t J K 0 B | G protein | protein NA | NA envelope glycoprotein bg505 ds-sosip gp41 | envelope glycoprotein bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 2.81 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8iuk E e 0 A protein NA g subunit alpha (q) MEMBRANE PROTEIN 07/12/23 Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex Homo sapiens; Lama glama; Mus musculus mus musculus homo sapiens Wu, C., Xu, Y., Xu, H.E. 2.67 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iuk N NA 0 A | B protein | protein NA | NA g subunit alpha (q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/12/23 Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Wu, C., Xu, Y., Xu, H.E. 2.67 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8ium E e 0 A protein NA g subunit alpha (q) MEMBRANE PROTEIN 07/12/23 Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex Homo sapiens; Lama glama; Mus musculus mus musculus homo sapiens Wu, C., Xu, Y., Xu, H.E. 3.14 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ium N NA 0 A | B protein | protein NA | NA g subunit alpha (q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/12/23 Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Wu, C., Xu, Y., Xu, H.E. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xd2 D J 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 SARS-CoV-2 S ectodomain trimer in complex with neutralizing antibody 10-5B Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xd2 E H 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 SARS-CoV-2 S ectodomain trimer in complex with neutralizing antibody 10-5B Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xd2 I L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 SARS-CoV-2 S ectodomain trimer in complex with neutralizing antibody 10-5B Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7y58 B NA 0 A protein NA antiseptic resistance protein MEMBRANE PROTEIN/IMMUNE SYSTEM 07/12/23 CryoEM structure of QacA (D411N), an antibacterial efflux transporter from Staphylococcus aureus Camelus dromedarius; Staphylococcus aureus camelus dromedarius staphylococcus aureus Penmatsa, A., Majumder, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y58 C NA 0 A protein NA antiseptic resistance protein MEMBRANE PROTEIN/IMMUNE SYSTEM 07/12/23 CryoEM structure of QacA (D411N), an antibacterial efflux transporter from Staphylococcus aureus Camelus dromedarius; Staphylococcus aureus camelus dromedarius staphylococcus aureus Penmatsa, A., Majumder, P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y8j H L 0 A peptide NA spike protein s2' ANTIMICROBIAL PROTEIN/IMMUNE SYSTEM 07/12/23 3D1 in complex with 6-mer HR1 peptide from SARS-CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lei, Y. 1.03 X-RAY DIFFRACTION 0.145 0.134 False True IGHV7 IGLV2 Lambda None None None None None 7yd1 A B 0 C protein NA spike protein s1 VIRAL PROTEIN 07/12/23 Local refinement of SARS-CoV-2 Omicron S trimer complexed with XG005 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 2.99 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7ydh E e 0 A | B protein | protein NA | NA g protein subunit 13 (gi2-mini-g13 chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/12/23 Cryo EM structure of CD97/miniG13 complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Wang, N. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ydj E e 0 A | B protein | protein NA | NA engineered mini-g12 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/12/23 Cryo EM structure of CD97/miniG12 complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Wang, N. 3.03 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ydm N NA 0 A | B protein | protein NA | NA engineered mini-gaq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/12/23 Cryo-EM structure of CD97/Gq complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Wang, N. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ydp D NA 0 A | B protein | protein NA | NA engineered minigas | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/12/23 Cryo-EM structure of CD97/miniGs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Wang, N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8byu H L 0 A protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 ANTITUMOR PROTEIN 07/12/23 Crystal Structure of HexaBody-CD38 Fab in complex with CD38 Homo sapiens homo sapiens homo sapiens homo sapiens Freier, R., Krapp, S., Hibbert, R.G. 1.85 X-RAY DIFFRACTION 0.230 0.188 False True IGHV1 IGKV1 Kappa None None None None None 8dkf H L 0 NA NA NA NA IMMUNE SYSTEM 07/12/23 Antibody DH1030.1 Fab fragment Homo sapiens homo sapiens homo sapiens Gobeil, S., Acharya, P. 1.79 X-RAY DIFFRACTION 0.274 0.239 False True IGHV3 IGKV2 Kappa None None None None None 8dkf A B 0 NA NA NA NA IMMUNE SYSTEM 07/12/23 Antibody DH1030.1 Fab fragment Homo sapiens homo sapiens homo sapiens Gobeil, S., Acharya, P. 1.79 X-RAY DIFFRACTION 0.274 0.239 False True IGHV3 IGKV2 Kappa None None None None None 8dmj D E 0 C protein NA fusion glycoprotein f0,fusion glycoprotein f1 VIRAL PROTEIN/Immune System 07/12/23 Postfusion Nipah virus fusion protein in complex with Fab 1H1 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., Blade, E.G., McLellan, J.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 8dmj H L 0 B protein NA fusion glycoprotein f0,fusion glycoprotein f1 VIRAL PROTEIN/Immune System 07/12/23 Postfusion Nipah virus fusion protein in complex with Fab 1H1 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., Blade, E.G., McLellan, J.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 8gto H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with XGv282 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8gto I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with XGv282 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8gto J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with XGv282 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8gtp H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with XGv289 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8gtp I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with XGv289 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8gtp J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with XGv289 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8gtq H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with S2L20 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gtq I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with S2L20 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gtq J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/12/23 cryo-EM structure of Omicron BA.5 S protein in complex with S2L20 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xia, X.Y., Zhang, Y.Y., Chi, X.M., Huang, B.D., Wu, L.S., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8iul E e 0 A | B protein | protein NA | NA g subunit alpha (q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/12/23 Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Wu, C., Xu, Y., Xu, H.E. 2.78 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ivw B C 0 A protein NA neuropilin-2 MEMBRANE PROTEIN 01/08/09 Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens Geng, Y., Zhai, L. 3.205 X-RAY DIFFRACTION 0.294 0.248 False True IGHV1 IGKV1 Kappa None None None None None 8ivw E F 0 D protein NA neuropilin-2 MEMBRANE PROTEIN 01/08/09 Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens Geng, Y., Zhai, L. 3.205 X-RAY DIFFRACTION 0.294 0.248 False True IGHV1 IGKV1 Kappa None None None None None 8ivw H I 0 G protein NA neuropilin-2 MEMBRANE PROTEIN 01/08/09 Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens Geng, Y., Zhai, L. 3.205 X-RAY DIFFRACTION 0.294 0.248 False True IGHV1 IGKV1 Kappa None None None None None 8ivw K L 0 J protein NA neuropilin-2 MEMBRANE PROTEIN 01/08/09 Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens Geng, Y., Zhai, L. 3.205 X-RAY DIFFRACTION 0.294 0.248 False True IGHV1 IGKV1 Kappa None None None None None 8ivx H L 0 A protein NA anrp2-14 MEMBRANE PROTEIN 01/08/09 Crystal structure of NRP2 in complex with aNRP2-14 Fab fragment Homo sapiens homo sapiens homo sapiens homo sapiens Geng, Y., Zhai, L. 1.9 X-RAY DIFFRACTION 0.225 0.191 False True IGHV2 IGKV6 Kappa None None None None None 8ded H L 0 K | J protein | protein NA | NA spike glycoprotein e2 | spike glycoprotein e1 VIRUS/IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW19 fab Homo sapiens; Western equine encephalitis virus homo sapiens homo sapiens western equine encephalitis virus | western equine encephalitis virus Pletnev, S., Tsybovsky, Y., Verardi, R., Roedeger, M., Kwong, P. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8ded U V 0 G | F protein | protein NA | NA spike glycoprotein e2 | spike glycoprotein e1 VIRUS/IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW19 fab Homo sapiens; Western equine encephalitis virus homo sapiens homo sapiens western equine encephalitis virus | western equine encephalitis virus Pletnev, S., Tsybovsky, Y., Verardi, R., Roedeger, M., Kwong, P. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8def S T 0 G | F protein | protein NA | NA spike glycoprotein e2 | spike glycoprotein e1 VIRUS/IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW24 fab Homo sapiens; Western equine encephalitis virus homo sapiens homo sapiens western equine encephalitis virus | western equine encephalitis virus Pletnev, S., Tsybovsky, Y., Verardi, R., Roedeger, M., Kwong, P.D. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8def U V 0 K | J protein | protein NA | NA spike glycoprotein e2 | spike glycoprotein e1 VIRUS/IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Western Equine Encephalitis Virus VLP in complex with SKW24 fab Homo sapiens; Western equine encephalitis virus homo sapiens homo sapiens western equine encephalitis virus | western equine encephalitis virus Pletnev, S., Tsybovsky, Y., Verardi, R., Roedeger, M., Kwong, P.D. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7y35 N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/05/23 Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhai, X., Mao, C., Shen, Q., Zang, S., Shen, D., Zhang, H., Chen, Z., Wang, G., Zhang, C., Zhang, Y., Liu, Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7y36 N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/05/23 Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhai, X., Mao, C., Shen, Q., Zang, S., Shen, D., Zhang, H., Chen, Z., Wang, G., Zhang, C., Zhang, Y., Liu, Z. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yc5 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yc5 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yc5 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yc5 G NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yc5 H NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yc5 I NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Cryo-EM structure of SARS-CoV-2 spike in complex with K202.B bispecific antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yoo, Y., Cho, H.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yd3 H L 0 NA NA NA NA ANTIMICROBIAL PROTEIN 07/05/23 Single-chain variable fragment of app 3D1 antibody Homo sapiens homo sapiens homo sapiens Yan, L., Yang, G. 2.16 X-RAY DIFFRACTION 0.254 0.217 False True IGHV7 IGLV2 Lambda None None None None None 7yd3 A B 0 NA NA NA NA ANTIMICROBIAL PROTEIN 07/05/23 Single-chain variable fragment of app 3D1 antibody Homo sapiens homo sapiens homo sapiens Yan, L., Yang, G. 2.16 X-RAY DIFFRACTION 0.254 0.217 False True IGHV7 IGLV2 Lambda None None None None None 7yd3 C D 0 NA NA NA NA ANTIMICROBIAL PROTEIN 07/05/23 Single-chain variable fragment of app 3D1 antibody Homo sapiens homo sapiens homo sapiens Yan, L., Yang, G. 2.16 X-RAY DIFFRACTION 0.254 0.217 False True IGHV7 IGLV2 Lambda None None None None None 7yd3 E F 0 NA NA NA NA ANTIMICROBIAL PROTEIN 07/05/23 Single-chain variable fragment of app 3D1 antibody Homo sapiens homo sapiens homo sapiens Yan, L., Yang, G. 2.16 X-RAY DIFFRACTION 0.254 0.217 False True IGHV7 IGLV2 Lambda None None None None None 7ym8 D NA 0 A protein NA alpha1a adrenergic receptor MEMBRANE PROTEIN 07/05/23 Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline Homo sapiens; synthetic construct synthetic construct homo sapiens Toyoda, Y., Zhu, A., Yan, C., Kobilka, B.K., Liu, X. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ymh D NA 0 A protein NA alpha1a-adrenergic receptor MEMBRANE PROTEIN 07/05/23 Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline Homo sapiens; synthetic construct synthetic construct homo sapiens Toyoda, Y., Zhu, A., Yan, C., Kobilka, B.K., Liu, X. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ymj D NA 0 A protein NA alpha1a-adrenergic receptor MEMBRANE PROTEIN 07/05/23 Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin Homo sapiens; Lama glama lama glama homo sapiens Toyoda, Y., Zhu, A., Yan, C., Kobilka, B.K., Liu, X. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c8t C D 0 A protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 01/08/09 cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Baquero, E., Molinos-Albert, L., Mouquet, H. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGLV2 Lambda None None None None None 8c8t H K 0 F protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 01/08/09 cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Baquero, E., Molinos-Albert, L., Mouquet, H. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGLV2 Lambda None None None None None 8c8t R T 0 F protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 01/08/09 cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Baquero, E., Molinos-Albert, L., Mouquet, H. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8c8t S U 0 G protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 01/08/09 cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Baquero, E., Molinos-Albert, L., Mouquet, H. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8cim D E 0 A protein NA spike glycoprotein,fibritin VIRUS 07/05/23 BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8cim F G 0 B protein NA spike glycoprotein,fibritin VIRUS 07/05/23 BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8cim H L 0 C protein NA spike glycoprotein,fibritin VIRUS 07/05/23 BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I., Fry, E.E. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8de3 B C 0 A protein NA transporter MEMBRANE PROTEIN 07/05/23 Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine Mus musculus; Sus scrofa mus musculus mus musculus sus scrofa Yang, D., Gouaux, E. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8de4 B C 0 A protein NA transporter MEMBRANE PROTEIN 07/05/23 Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine Mus musculus; Sus scrofa mus musculus mus musculus sus scrofa Yang, D., Gouaux, E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dgr A a 0 NA NA NA NA IMMUNE SYSTEM 07/05/23 Crystal Structure of scFv(F8) Antibody Fragment Artichoke mottled crinkle virus artichoke mottled crinkle virus Mrozek, A., Park, H.W. 1.56 X-RAY DIFFRACTION 0.195 0.175 True True unknown unknown unknown None None None None None 8dul H L 0 A | K protein | protein NA | NA spike glycoprotein e1 | spike glycoprotein e2 IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Antibody SKT05 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) Macaca fascicularis; Western equine encephalitis virus macaca fascicularis macaca fascicularis western equine encephalitis virus | western equine encephalitis virus Cerutti, G., Verardi, R., Roederer, M., Shapiro, L. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dun H L 0 G protein NA spike glycoprotein e2 IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) Macaca fascicularis; Western equine encephalitis virus macaca fascicularis macaca fascicularis western equine encephalitis virus Cerutti, G., Verardi, R., Roederer, M., Shapiro, L. 5.84 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dun I M 0 K protein NA spike glycoprotein e2 IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) Macaca fascicularis; Western equine encephalitis virus macaca fascicularis macaca fascicularis western equine encephalitis virus Cerutti, G., Verardi, R., Roederer, M., Shapiro, L. 5.84 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dun N O 0 B protein NA spike glycoprotein e2 IMMUNE SYSTEM 07/05/23 Cryo-EM Structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) Macaca fascicularis; Western equine encephalitis virus macaca fascicularis macaca fascicularis western equine encephalitis virus Cerutti, G., Verardi, R., Roederer, M., Shapiro, L. 5.84 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8duz A B 0 F peptide NA mimetic peptide IMMUNE SYSTEM 07/05/23 Protective antibody against gonococcal lipooligosaccharide bound to peptide mimetic Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bacteriophage sp. Beernink, P.T., Beernink, B.P., Rice, P.A., Ram, S. 1.65 X-RAY DIFFRACTION 0.234 0.189 False True IGHV1 IGLV1 Lambda None None None None None 8duz C D 0 E peptide NA mimetic peptide IMMUNE SYSTEM 07/05/23 Protective antibody against gonococcal lipooligosaccharide bound to peptide mimetic Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bacteriophage sp. Beernink, P.T., Beernink, B.P., Rice, P.A., Ram, S. 1.65 X-RAY DIFFRACTION 0.234 0.189 False True IGHV1 IGLV1 Lambda None None None None None 8elo H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-225 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.72 X-RAY DIFFRACTION 0.261 0.220 False True IGHV3 IGKV1 Kappa None None None None None 8elo B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-225 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.72 X-RAY DIFFRACTION 0.261 0.220 False True IGHV3 NA NA None None None None None 8elp H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-240 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.83 X-RAY DIFFRACTION 0.284 0.238 False True IGHV3 IGKV1 Kappa None None None None None 8elp B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-240 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.83 X-RAY DIFFRACTION 0.284 0.238 False True IGHV3 NA NA None None None None None 8elq H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-255 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.21 X-RAY DIFFRACTION 0.285 0.234 False True IGHV3 IGKV1 Kappa None None None None None 8elq B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/05/23 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-255 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.21 X-RAY DIFFRACTION 0.285 0.234 False True IGHV3 NA NA None None None None None 8pii A NA 0 B peptide NA microtubule-associated protein tau IMMUNE SYSTEM 07/05/23 VHH Z70 mutant 1 in interaction with PHF6 Tau peptide Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens Dupre, E., Mortelecque, J., NGuyen, M., Hanoulle, X., Landrieu, I. 2.35 X-RAY DIFFRACTION 0.263 0.200 False True IGHV3 NA NA None None None None None 8dt8 H NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/14/23 LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein (focused refinement) Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dt8 D NA 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 06/14/23 LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein (focused refinement) Severe acute respiratory syndrome coronavirus 2; synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7u0g N n 0 G | E | H protein | protein | protein NA | NA | NA histone h2a type 2-c | histone h3.1 | histone h2b type 2-e TRANSCRIPTION/DNA 06/28/23 structure of LIN28b nucleosome bound 3 OCT4 Escherichia coli K-12; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7u0g O o 0 C | D protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 06/28/23 structure of LIN28b nucleosome bound 3 OCT4 Escherichia coli K-12; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7u0i K k 0 G | E | H | F protein | protein | protein | protein NA | NA | NA | NA histone h2a type 2-c | histone h3.1 | histone h2b type 2-e | histone h4 TRANSCRIPTION/DNA 06/28/23 Structure of LIN28b nucleosome bound 2 OCT4 Escherichia coli K-12; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens | homo sapiens Tengfei, L., Guan, R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7u0i N n 0 C | D protein | protein NA | NA histone h2a type 2-c | histone h2b type 2-e TRANSCRIPTION/DNA 06/28/23 Structure of LIN28b nucleosome bound 2 OCT4 Escherichia coli K-12; Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Tengfei, L., Guan, R., Bai, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7u0j K k 0 G | E | H | F protein | protein | protein | protein NA | NA | NA | NA histone h2a type 2-c | histone h3.1 | histone h2b type 2-e | histone h4 TRANSCRIPTION/DNA 06/28/23 Structure of 162bp LIN28b nucleosome Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7u0j N n 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 2-c | histone h4 | histone h2b type 2-e TRANSCRIPTION/DNA 06/28/23 Structure of 162bp LIN28b nucleosome Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7zor I M 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-Siglec-15 Fab Homo sapiens homo sapiens homo sapiens Lenza, M.P., Oyenarte, I., Jimenez-Barbero, J., Ereno-Orbea, J. 3.933 X-RAY DIFFRACTION 0.273 0.229 False True IGHV1 IGKV14 Kappa None None None None None 7zor H L 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-Siglec-15 Fab Homo sapiens homo sapiens homo sapiens Lenza, M.P., Oyenarte, I., Jimenez-Barbero, J., Ereno-Orbea, J. 3.933 X-RAY DIFFRACTION 0.273 0.229 False True IGHV1 IGKV14 Kappa None None None None None 7zoz H L 0 A protein NA sialic acid-binding ig-like lectin 15 IMMUNE SYSTEM 06/28/23 Crystal structure of Siglec-15 in complex with Fab Homo sapiens homo sapiens homo sapiens homo sapiens Lenza, M.P., Oyenarte, I., Jimenez-Barbero, J., Ereno-Orbea, J. 2.104 X-RAY DIFFRACTION 0.218 0.176 False True IGHV1 IGKV14 Kappa None None None None None 8sps K k 0 G | E | L | H | F protein | protein | protein | protein | protein NA | NA | NA | NA | NA histone h2a type 2-c | histone h3.1 | maltodextrin-binding protein,pou domain, class 5,transcription factor 1 | histone h2b type 2-e | histone h4 TRANSCRIPTION/DNA 06/28/23 High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens | homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8sps N n 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 2-c | histone h4 | histone h2b type 2-e TRANSCRIPTION/DNA 06/28/23 High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8spu N n 0 C | B | D | A protein | protein | protein | protein NA | NA | NA | NA histone h2a type 2-c | histone h4 | histone h2b type 2-e | histone h3.1 TRANSCRIPTION/DNA 06/28/23 Structure of ESRRB nucleosome bound OCT4 at site c Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8spu K k 0 G | H | F protein | protein | protein NA | NA | NA histone h2a type 2-c | histone h2b type 2-e | histone h4 TRANSCRIPTION/DNA 06/28/23 Structure of ESRRB nucleosome bound OCT4 at site c Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens | homo sapiens | homo sapiens Lian, T., Guan, R., Bai, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8e1g H L 0 A protein NA spike protein s1 VIRAL PROTEIN 06/28/23 SARS-CoV-2 RBD in complex with Omicron-neutralizing antibody 2A10 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wasserman, H., Hastie, K.M., Buck, T.K., Saphire, E.O. 2.57 X-RAY DIFFRACTION 0.244 0.196 False True IGHV3 IGKV1 Kappa None None None None None 8e1g V T 0 B protein NA spike protein s1 VIRAL PROTEIN 06/28/23 SARS-CoV-2 RBD in complex with Omicron-neutralizing antibody 2A10 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wasserman, H., Hastie, K.M., Buck, T.K., Saphire, E.O. 2.57 X-RAY DIFFRACTION 0.244 0.196 False True IGHV3 IGKV1 Kappa None None None None None 8gou I J 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8gou H K 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8guz A B 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FIXa IgG fab with FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 1.79 X-RAY DIFFRACTION 0.273 0.201 False True IGHV3 IGKV3 Kappa None None None None None 8guz C D 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FIXa IgG fab with FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 1.79 X-RAY DIFFRACTION 0.273 0.201 False True IGHV3 IGKV3 Kappa None None None None None 8gv1 A B 0 NA NA NA NA IMMUNE SYSTEM 06/28/23 Crystal structure of anti-FX IgG fab with FAST-Ig mutations Homo sapiens homo sapiens homo sapiens Koga, H., Yamano, T., Fukami, T.A., Sampei, Z., Shiraiwa, H., Torizawa, T. 1.186 X-RAY DIFFRACTION 0.227 0.206 False True IGHV1 IGLV3 Lambda None None None None None 8jlz N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/28/23 ST1936-5HT6R complex Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens | homo sapiens Wen, X., Sun, J. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8smt A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/28/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV3 Lambda None None None None None 8smt D F 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/28/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV3 Lambda None None None None None 8smt H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/28/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV3 Lambda None None None None None 8smt I J 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/28/23 Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Jensen, J.L., Joyce, M.G. 3.16 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV3 Lambda None None None None None 7ytn H L 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Crystal structure of SARS-CoV-2 Alpha RBD in complex with the D27LEY neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jeong, B.S., Jeon, J.Y., Oh, B.H. 3.51 X-RAY DIFFRACTION 0.274 0.237 False True IGHV1 IGLV3 Lambda None None None None None 7yve I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7yve L K 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7yve O N 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7yvf C A 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH027 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7yvg I H 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvg K J 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvg M L 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvh C A 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvi J H 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH236 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7yvi O N 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH236 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7yvi K I 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH236 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7yvj C A 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH236 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7yvk H I 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7yvk K L 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7yvk N O 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7yvl A C 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH272 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7yvm C A 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH272 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvn L K 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvn O N 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvn NA H 0 NA NA NA NA VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True NA IGKV3 Kappa None None None None None 7yvn I NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yvo I H 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH027/132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvo K J 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH027/132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvo M L 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH027/132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7yvo O N 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH027/132 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7yvp L M 0 C protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7yvp P O 0 C protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvp K H 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7yvp I NA 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV2 NA NA None None None None None 7yvp NA J 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/28/23 Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Zhang, G., Liang, J., Liu, F., Rao, Z. 3.8 ELECTRON MICROSCOPY NA NA False True NA IGLV2 Lambda None None None None None 8deq H L 0 F | D protein | protein NA | NA spike glycoprotein e1 | spike glycoprotein e1 VIRAL PROTEIN 06/28/23 Cryo-EM local refinement of antibody SKV09 in complex with VEEV alphavirus spike glycoprotein Macaca; Venezuelan equine encephalitis virus macaca macaca venezuelan equine encephalitis virus | venezuelan equine encephalitis virus Casner, R.G., Verardi, R., Roederer, M., Shapiro, L. 6.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8der X Y 0 B protein NA spike glycoprotein e2 VIRAL PROTEIN 06/28/23 Cryo-EM local refinement of antibody SKV16 in complex with VEEV alphavirus spike glycoprotein Macaca; Venezuelan equine encephalitis virus macaca macaca venezuelan equine encephalitis virus Casner, R.G., Verardi, R., Roederer, M., Shapiro, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8der H L 0 A protein NA spike glycoprotein e2 VIRAL PROTEIN 06/28/23 Cryo-EM local refinement of antibody SKV16 in complex with VEEV alphavirus spike glycoprotein Macaca; Venezuelan equine encephalitis virus macaca macaca venezuelan equine encephalitis virus Casner, R.G., Verardi, R., Roederer, M., Shapiro, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8der W V 0 C protein NA spike glycoprotein e2 VIRAL PROTEIN 06/28/23 Cryo-EM local refinement of antibody SKV16 in complex with VEEV alphavirus spike glycoprotein Macaca; Venezuelan equine encephalitis virus macaca macaca venezuelan equine encephalitis virus Casner, R.G., Verardi, R., Roederer, M., Shapiro, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8pe9 H L 0 A protein NA epithelial discoidin domain-containing receptor 1 IMMUNE SYSTEM 06/28/23 Complex between DDR1 DS-like domain and PRTH-101 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Liu, J., Chiang, H., Xiong, W., Laurent, V., Griffiths, S.C., Duelfer, J., Deng, H., Sun, X., Yin, Y.W., Li, W., Audoly, L.P., An, Z., Schuerpf, T., Li, R., Zhang, N. 3.152 X-RAY DIFFRACTION 0.309 0.278 False True IGHV3 IGKV1 Kappa None None None None None 7y6l H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/21/23 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab816 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Uchikubo, T., Shirouzu, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7y6n H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/21/23 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab803 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Uchikubo, T., Shirouzu, M. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8doz A B 0 NA NA NA NA IMMUNE SYSTEM 06/21/23 Protective antibody against gonococcal lipooligosaccharide Mus musculus mus musculus mus musculus Beernink, P.T. 1.7 X-RAY DIFFRACTION 0.216 0.177 False True IGHV1 IGLV1 Lambda None None None None None 8doz C D 0 NA NA NA NA IMMUNE SYSTEM 06/21/23 Protective antibody against gonococcal lipooligosaccharide Mus musculus mus musculus mus musculus Beernink, P.T. 1.7 X-RAY DIFFRACTION 0.216 0.177 False True IGHV1 IGLV1 Lambda None None None None None 8e1m H L 0 C protein NA mitochondrial import inner membrane translocase subunittim44 TRANSLOCASE/IMMUNE SYSTEM 06/21/23 Cryo-EM structure of the endogenous core TIM23 complex from S. cerevisiae Mus musculus; Saccharomyces cerevisiae mus musculus mus musculus saccharomyces cerevisiae Sim, S.I., Park, E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 8e1p F I 0 E protein NA bg505-sosip.v4.1-gt1.2gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Kumar, S., Wilson, I.A. 3.82 X-RAY DIFFRACTION 0.301 0.271 False True IGHV1 IGLV2 Lambda None None None None None 8e1p H L 0 G protein NA bg505-sosip.v4.1-gt1.2gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Kumar, S., Wilson, I.A. 3.82 X-RAY DIFFRACTION 0.301 0.271 False True IGHV1 IGLV2 Lambda None None None None None 8e1p N O 0 M protein NA bg505-sosip.v4.1-gt1.2gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Kumar, S., Wilson, I.A. 3.82 X-RAY DIFFRACTION 0.301 0.271 False True IGHV1 IGLV2 Lambda None None None None None 8e1p B A 0 G protein NA bg505-sosip.v4.1-gt1.2gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Kumar, S., Wilson, I.A. 3.82 X-RAY DIFFRACTION 0.301 0.271 False True IGHV4 unknown unknown None None None None None 8e1p D C 0 E protein NA bg505-sosip.v4.1-gt1.2gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Kumar, S., Wilson, I.A. 3.82 X-RAY DIFFRACTION 0.301 0.271 False True IGHV4 unknown unknown None None None None None 8e1p K J 0 M protein NA bg505-sosip.v4.1-gt1.2gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Kumar, S., Wilson, I.A. 3.82 X-RAY DIFFRACTION 0.301 0.271 False True IGHV4 unknown unknown None None None None None 8e8l H L 0 1 | 2 | 3 protein | protein | protein NA | NA | NA capsid protein vp1 | capsid protein vp2 | capsid protein vp3 VIRUS/IMMUNE SYSTEM 06/21/23 9H2 Fab-poliovirus 1 complex Homo sapiens; Human poliovirus 1 Mahoney homo sapiens homo sapiens human poliovirus 1 mahoney | human poliovirus 1 mahoney | human poliovirus 1 mahoney Charnesky, A.J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8e8r H L 0 1 | 2 | 3 protein | protein | protein NA | NA | NA capsid protein vp1 | capsid protein vp2 | capsid protein vp3 VIRUS/IMMUNE SYSTEM 06/21/23 9H2 Fab-Sabin poliovirus 3 complex Homo sapiens; Human poliovirus 3 strain Sabin homo sapiens homo sapiens human poliovirus 3 strain sabin | human poliovirus 3 strain sabin | human poliovirus 3 strain sabin Charnesky, A.J. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8e8s H L 0 1 | 2 | 3 protein | protein | protein NA | NA | NA capsid protein vp1 | capsid protein vp2 | capsid protein vp3 VIRUS/IMMUNE SYSTEM 06/21/23 9H2 Fab-poliovirus 2 complex Homo sapiens; Poliovirus 2 homo sapiens homo sapiens poliovirus 2 | poliovirus 2 | poliovirus 2 Charnesky, A.J. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8e8x H L 0 1 | 2 | 3 protein | protein | protein NA | NA | NA capsid protein vp1 | capsid protein vp2 | capsid protein vp3 VIRUS/IMMUNE SYSTEM 06/21/23 9H2 Fab-Sabin poliovirus 3 complex Homo sapiens; Human poliovirus 3 strain Sabin homo sapiens homo sapiens human poliovirus 3 strain sabin | human poliovirus 3 strain sabin | human poliovirus 3 strain sabin Charnesky, A.J. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8e8y H L 0 1 | 2 | 3 protein | protein | protein NA | NA | NA capsid protein vp1 | capsid protein vp2 | capsid protein vp3 VIRUS/IMMUNE SYSTEM 06/21/23 9H2 Fab-Sabin poliovirus 2 complex Homo sapiens; Human poliovirus 2 strain Sabin homo sapiens homo sapiens human poliovirus 2 strain sabin | human poliovirus 2 strain sabin | human poliovirus 2 strain sabin Charnesky, A.J. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8e8z H L 0 1 | 2 | 3 protein | protein | protein NA | NA | NA capsid protein vp1 | capsid protein vp2 | capsid protein vp3 VIRUS/IMMUNE SYSTEM 06/21/23 9H2 Fab-Sabin poliovirus 1 complex Homo sapiens; Human poliovirus 1 strain Sabin homo sapiens homo sapiens human poliovirus 1 strain sabin | human poliovirus 1 strain sabin | human poliovirus 1 strain sabin Charnesky, A.J. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8fxs D NA 0 A protein NA transforming growth factor beta-2 proprotein CYTOKINE 06/21/23 Crystal structure of human pro-TGF-beta2 in complex with Nb9 Homo sapiens; synthetic construct synthetic construct homo sapiens Le, V.Q., Springer, T.A. 3.15 X-RAY DIFFRACTION 0.301 0.249 False True IGHV1 NA NA None None None None None 8fxs E NA 0 B protein NA transforming growth factor beta-2 proprotein CYTOKINE 06/21/23 Crystal structure of human pro-TGF-beta2 in complex with Nb9 Homo sapiens; synthetic construct synthetic construct homo sapiens Le, V.Q., Springer, T.A. 3.15 X-RAY DIFFRACTION 0.301 0.249 False True IGHV1 NA NA None None None None None 8fxv B NA 0 A protein NA transforming growth factor beta-2 proprotein CYTOKINE 06/21/23 Crystal structure of human proTGF-beta2 in complex with Nb18 Homo sapiens; synthetic construct synthetic construct homo sapiens Le, V.Q., Springer, T.A. 2.2 X-RAY DIFFRACTION 0.249 0.227 False True IGHV1 NA NA None None None None None 8h4i D NA 0 A | B protein | protein NA | NA engineered mini galpha-s subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/21/23 DHA-bound FFAR4 in complex with Gs Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Yin, H. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8h4k N NA 0 A | B protein | protein NA | NA engineered mini galpha-q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/21/23 GW9508-bound FFAR4 in complex with Gq Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Yin, H. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8h4l N NA 0 A | B protein | protein NA | NA engineered mini galpha-q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 06/21/23 DHA-bound FFAR4 in complex with Gq Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Yin, H. 3.07 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8hbv B NA 0 A protein NA mitochondrial brown fat uncoupling protein 1 MEMBRANE PROTEIN 06/21/23 Structure of human UCP1 in the nucleotide-free state Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Chen, L., Kang, Y. 2.51 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hbw B NA 0 A protein NA mitochondrial brown fat uncoupling protein 1 MEMBRANE PROTEIN 06/21/23 Structure of human UCP1 in the ATP-bound state Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Chen, L., Kang, Y. 2.57 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hmp N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 06/21/23 GPR52 with Gs and c17 Homo sapiens homo sapiens homo sapiens | homo sapiens Chen, B., Xu, F. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8idn H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/21/23 Cryo-EM structure of RBD/E77-Fab complex Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Lu, D.F., Zhang, Z.C. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 8ilx C NA 0 A protein NA mcherry fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 06/21/23 mCherry-LaM3 complex Anaplasma marginale; Camelus bactrianus camelus bactrianus anaplasma marginale Liang, H., Liu, R., Ding, Y. 3.29 X-RAY DIFFRACTION 0.312 0.264 False True IGHV1 NA NA None None None None None 8ilx D NA 0 B protein NA mcherry fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 06/21/23 mCherry-LaM3 complex Anaplasma marginale; Camelus bactrianus camelus bactrianus anaplasma marginale Liang, H., Liu, R., Ding, Y. 3.29 X-RAY DIFFRACTION 0.312 0.264 False True IGHV1 NA NA None None None None None 8im0 B NA 0 A protein NA mcherry fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 06/21/23 mCherry-LaM8 complex Anaplasma marginale; Camelus bactrianus camelus bactrianus anaplasma marginale Liang, H., Liu, R., Ding, Y. 1.31 X-RAY DIFFRACTION 0.190 0.178 False True IGHV1 NA NA None None None None None 8im1 B NA 0 A protein NA mcherry fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 06/21/23 mCherry-LaM1 complex Anaplasma marginale; Camelus bactrianus camelus bactrianus anaplasma marginale Liang, H., Liu, R., Ding, Y. 2.05 X-RAY DIFFRACTION 0.235 0.205 False True IGHV1 NA NA None None None None None 8im1 D NA 0 C protein NA mcherry fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 06/21/23 mCherry-LaM1 complex Anaplasma marginale; Camelus bactrianus camelus bactrianus anaplasma marginale Liang, H., Liu, R., Ding, Y. 2.05 X-RAY DIFFRACTION 0.235 0.205 False True IGHV1 NA NA None None None None None 8im1 F NA 0 E protein NA mcherry fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 06/21/23 mCherry-LaM1 complex Anaplasma marginale; Camelus bactrianus camelus bactrianus anaplasma marginale Liang, H., Liu, R., Ding, Y. 2.05 X-RAY DIFFRACTION 0.235 0.205 False True IGHV1 NA NA None None None None None 8im1 H NA 0 G protein NA mcherry fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 06/21/23 mCherry-LaM1 complex Anaplasma marginale; Camelus bactrianus camelus bactrianus anaplasma marginale Liang, H., Liu, R., Ding, Y. 2.05 X-RAY DIFFRACTION 0.235 0.205 False True IGHV1 NA NA None None None None None 8irr N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/23 Dopamine Receptor D1R-Gs-Rotigotine complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Xu, P., Huang, S., Zhuang, Y., Mao, C., Zhang, Y., Wang, Y., Li, H., Jiang, Y., Zhang, Y., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8iru E e 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/23 Dopamine Receptor D4R-Gi-Rotigotine complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Xu, P., Huang, S., Zhuang, Y., Mao, C., Zhang, Y., Wang, Y., Li, H., Jiang, Y., Zhang, Y., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iys E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/23 TUG891-bound FFAR4 in complex with Gq Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Yin, H. 2.95 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j18 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 06/21/23 Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Liu, H., Yin, W., Xu, H.E. 2.89 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j19 S s 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 06/21/23 Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Liu, H., Yin, W., Xu, H.E. 3.23 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j1a S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 06/21/23 Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Liu, H., Yin, W., Xu, H.E. 3.24 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8j1n B NA 0 A protein NA mitochondrial brown fat uncoupling protein 1 MEMBRANE PROTEIN 06/21/23 Structure of human UCP1 in the DNP-bound state Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Chen, L., Kang, Y. 2.51 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8j1q B A 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM/DNA 06/21/23 CryoEM structure of SARS CoV-2 RBD and Aptamer complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rahman, M.S., Jang, S.K., Lee, J.O. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8j26 B A 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM/DNA 06/21/23 CryoEM structure of SARS CoV-2 RBD and Aptamer complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rahman, M.S., Jang, S.K., Lee, J.O. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8jbj A B 0 NA NA NA NA IMMUNE SYSTEM 06/21/23 Crystal structure of anti-PVRIG Fab Homo sapiens homo sapiens homo sapiens Sun, J., Li, X.L., Song, J. 1.61 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV3 Kappa None None None None None 8jbj C D 0 NA NA NA NA IMMUNE SYSTEM 06/21/23 Crystal structure of anti-PVRIG Fab Homo sapiens homo sapiens homo sapiens Sun, J., Li, X.L., Song, J. 1.61 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV3 Kappa None None None None None 8jd5 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/23 Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer Escherichia coli; Homo sapiens homo sapiens | homo sapiens Wang, X., Wang, M., Xu, T., Feng, Y., Han, S., Zhao, Q., Wu, B. 3.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8jd6 D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/23 Cryo-EM structure of Gi1-bound metabotropic glutamate receptor mGlu4 Escherichia coli; Homo sapiens homo sapiens | homo sapiens Wang, X., Wang, M., Xu, T., Feng, Y., Han, S., Lin, S., Zhao, Q., Wu, B. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8scx H L 0 C protein NA mitochondrial import inner membrane translocase subunittim44 TRANSLOCASE 06/21/23 Cryo-EM structure of the core TIM23 complex from S. cerevisiae Mus musculus; Saccharomyces cerevisiae mus musculus mus musculus saccharomyces cerevisiae Sim, S.I., Park, E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV3 Kappa None None None None None 7y1b H L 0 A protein NA isoform 2 of basigin TRANSPORT PROTEIN 06/14/23 3.2 angstrom cryo-EM structure of extracellular region of mouse Basigin-2 in complex with the Fab fragment of antibody 6E7F1 Mus musculus mus musculus mus musculus mus musculus Zhang, H., Yang, X., Xue, Y., Huang, Y., Mo, X., Zhang, H., Li, N., Gao, N., Li, X., Wang, S., Gao, Y., Liao, J. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 8aok B NA 0 A protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 06/14/23 Complex of PD-L1 with VHH6 Homo sapiens; Lama glama lama glama homo sapiens Kang-Pettinger, T., Hall, G. 1.6 X-RAY DIFFRACTION 0.185 0.162 False True IGHV1 NA NA None None None None None 8aom V NA 0 A protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 06/14/23 Complex of PD-L1 with VHH1 Homo sapiens; Lama glama lama glama homo sapiens Kang-Pettinger, T., Hall, G. 2.202 X-RAY DIFFRACTION 0.245 0.208 False True IGHV1 NA NA None None None None None 8d9y B A 0 I protein NA long neurotoxin 1 IMMUNE SYSTEM,ANTITOXIN/TOXIN 06/14/23 Crystal structure of Taipan alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Homo sapiens; Oxyuranus scutellatus scutellatus homo sapiens homo sapiens oxyuranus scutellatus scutellatus Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8d9y D C 0 J protein NA long neurotoxin 1 IMMUNE SYSTEM,ANTITOXIN/TOXIN 06/14/23 Crystal structure of Taipan alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Homo sapiens; Oxyuranus scutellatus scutellatus homo sapiens homo sapiens oxyuranus scutellatus scutellatus Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8d9y F E 0 K protein NA long neurotoxin 1 IMMUNE SYSTEM,ANTITOXIN/TOXIN 06/14/23 Crystal structure of Taipan alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Homo sapiens; Oxyuranus scutellatus scutellatus homo sapiens homo sapiens oxyuranus scutellatus scutellatus Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8d9y H G 0 L protein NA long neurotoxin 1 IMMUNE SYSTEM,ANTITOXIN/TOXIN 06/14/23 Crystal structure of Taipan alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Homo sapiens; Oxyuranus scutellatus scutellatus homo sapiens homo sapiens oxyuranus scutellatus scutellatus Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8d9z B A 0 D protein NA long neurotoxin 1 IMMUNE SYSTEM,ANTITOXIN/TOXIN 06/14/23 Crystal structure of Cobra alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Homo sapiens; Naja nivea homo sapiens homo sapiens naja nivea Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.198 0.165 False True IGHV3 IGKV1 Kappa None None None None None 8da0 B A 0 E protein NA alpha-elapitoxin-dpp2d IMMUNE SYSTEM,ANTITOXIN/TOXIN 06/14/23 Crystal structure of Mamba alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Dendroaspis polylepis polylepis; Homo sapiens homo sapiens homo sapiens dendroaspis polylepis polylepis Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.249 0.196 False True IGHV3 IGKV1 Kappa None None None None None 8da0 D C 0 F peptide NA alpha-elapitoxin-dpp2d IMMUNE SYSTEM,ANTITOXIN/TOXIN 06/14/23 Crystal structure of Mamba alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Dendroaspis polylepis polylepis; Homo sapiens homo sapiens homo sapiens dendroaspis polylepis polylepis Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.249 0.196 False True IGHV3 IGKV1 Kappa None None None None None 8da1 B A 0 I protein NA alpha-bungarotoxin IMMUNE SYSTEM, ANTITOXIN/TOXIN 06/14/23 Crystal structure of Krait alpha-neurotoxin in complex with Centi-3FTX-D09 antibody Bungarus multicinctus; Homo sapiens homo sapiens homo sapiens bungarus multicinctus Pletnev, S., Verardi, R., Tully, E.S., Glanville, J., Kwong, P.D. 2.67 X-RAY DIFFRACTION 0.241 0.185 False True IGHV3 IGKV1 Kappa None None None None None 8eoo A B 0 C protein NA spike protein s1 VIRAL PROTEIN 06/14/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibodies WRAIR-2063 and WRAIR-2151 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Sankhala, R.S., Joyce, M.G. 2.77 X-RAY DIFFRACTION 0.255 0.194 False False IGHV4 IGLV6 Lambda None None None None None 8eoo E J 0 D protein NA spike protein s1 VIRAL PROTEIN 06/14/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibodies WRAIR-2063 and WRAIR-2151 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Sankhala, R.S., Joyce, M.G. 2.77 X-RAY DIFFRACTION 0.255 0.194 False False IGHV3 IGKV2 Kappa None None None None None 8eoo F K 0 D protein NA spike protein s1 VIRAL PROTEIN 06/14/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibodies WRAIR-2063 and WRAIR-2151 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Sankhala, R.S., Joyce, M.G. 2.77 X-RAY DIFFRACTION 0.255 0.194 False False IGHV4 IGLV6 Lambda None None None None None 8eoo H L 0 C protein NA spike protein s1 VIRAL PROTEIN 06/14/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibodies WRAIR-2063 and WRAIR-2151 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jensen, J.L., Sankhala, R.S., Joyce, M.G. 2.77 X-RAY DIFFRACTION 0.255 0.194 False False IGHV3 IGKV2 Kappa None None None None None 8esv H L 0 A protein NA disintegrin and metalloproteinase domain-containing protein10 MEMBRANE PROTEIN 06/14/23 Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lipper, C.H., Blacklow, S.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV4 Kappa None None None None None 8gw8 N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 06/14/23 the human PTH1 receptor bound to an intracellular biased agonist Bos taurus; Homo sapiens; Rattus norvegicus; unidentified unidentified homo sapiens | rattus norvegicus Kobayashi, K., Kusakizako, T., Okamoto, H.H., Nureki, O. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8ojs B A 0 NA NA NA NA IMMUNE SYSTEM 06/14/23 Crystal structure of the human IgD Fab - structure Fab1 Homo sapiens homo sapiens homo sapiens Davies, A.M., Beavil, R.L., McDonnell, J.M. 2.75 X-RAY DIFFRACTION 0.256 0.216 False True IGHV1 IGLV1 Lambda None None None None None 8ojs H L 0 NA NA NA NA IMMUNE SYSTEM 06/14/23 Crystal structure of the human IgD Fab - structure Fab1 Homo sapiens homo sapiens homo sapiens Davies, A.M., Beavil, R.L., McDonnell, J.M. 2.75 X-RAY DIFFRACTION 0.256 0.216 False True IGHV1 IGLV1 Lambda None None None None None 8ojt H L 0 NA NA NA NA IMMUNE SYSTEM 06/14/23 Crystal structure of the human IgD Fab - structure Fab2 Homo sapiens homo sapiens homo sapiens Davies, A.M., Beavil, R.L., McDonnell, J.M. 1.55 X-RAY DIFFRACTION 0.198 0.161 False True IGHV1 IGLV1 Lambda None None None None None 8oju H L 0 NA NA NA NA IMMUNE SYSTEM 06/14/23 Crystal structure of the human IgD Fab - structure Fab3 Homo sapiens homo sapiens homo sapiens Davies, A.M., Beavil, R.L., McDonnell, J.M. 1.45 X-RAY DIFFRACTION 0.189 0.157 False True IGHV1 IGLV1 Lambda None None None None None 8ojv H L 0 NA NA NA NA IMMUNE SYSTEM 06/14/23 Crystal structure of the human IgD Fab - structure Fab4 Homo sapiens homo sapiens homo sapiens Davies, A.M., Beavil, R.L., McDonnell, J.M. 2.1 X-RAY DIFFRACTION 0.216 0.179 False True IGHV1 IGLV1 Lambda None None None None None 8cxc H L 0 M protein NA mesothelin, cleaved form ANTITUMOR PROTEIN 06/07/23 Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E. 4.31 X-RAY DIFFRACTION 0.300 0.244 False True IGHV3 IGKV1 Kappa None None None None None 8cxc B A 0 M protein NA mesothelin, cleaved form ANTITUMOR PROTEIN 06/07/23 Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E. 4.31 X-RAY DIFFRACTION 0.300 0.244 False True IGHV1 IGKV4 Kappa None None None None None 8cxh H L 0 A protein NA ankyrin repeat family a protein 2,envelope e protein VIRUS/IMMUNE SYSTEM 01/08/09 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Liu, W., Zhang, X.K., Gong, D.Y., Dai, X.H., Sharma, A., Zhang, T.H., Rey, F., Zhou, Z.H. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8cxh h l 0 C | B protein | protein NA | NA ankyrin repeat family a protein 2,envelope e protein | ankyrin repeat family a protein 2,envelope e protein VIRUS/IMMUNE SYSTEM 01/08/09 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy Homo sapiens; Zika virus homo sapiens homo sapiens zika virus | zika virus Liu, W., Zhang, X.K., Gong, D.Y., Dai, X.H., Sharma, A., Zhang, T.H., Rey, F., Zhou, Z.H. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 IGLV2 Lambda None None None None None 8cxi H L 0 A protein NA ankyrin repeat family a protein 2,envelope e protein VIRUS/IMMUNE SYSTEM 06/07/23 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Liu, W., Zhang, X.K., Gong, D.Y., Dai, X.H., Sharma, A., Zhang, T.H., Rey, F., Zhou, Z.H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8cxi h l 0 C | B protein | protein NA | NA ankyrin repeat family a protein 2,envelope e protein | ankyrin repeat family a protein 2,envelope e protein VIRUS/IMMUNE SYSTEM 06/07/23 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy Homo sapiens; Zika virus homo sapiens homo sapiens zika virus | zika virus Liu, W., Zhang, X.K., Gong, D.Y., Dai, X.H., Sharma, A., Zhang, T.H., Rey, F., Zhou, Z.H. 3.4 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 8cyh H L 0 M protein NA mesothelin, cleaved form ANTITUMOR PROTEIN 06/07/23 Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Homo sapiens homo sapiens homo sapiens homo sapiens Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E. 3.38 X-RAY DIFFRACTION 0.268 0.230 False True IGHV3 IGKV1 Kappa None None None None None 8cz8 C c 0 E protein NA mesothelin, cleaved form ANTITUMOR PROTEIN 06/07/23 Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Homo sapiens homo sapiens homo sapiens Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E. 2.6 X-RAY DIFFRACTION 0.224 0.190 True True unknown unknown unknown None None None None None 8cz8 D d 0 E protein NA mesothelin, cleaved form ANTITUMOR PROTEIN 06/07/23 Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Homo sapiens homo sapiens homo sapiens Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E. 2.6 X-RAY DIFFRACTION 0.224 0.190 True True unknown unknown unknown None None None None None 8cz8 A a 0 M protein NA mesothelin, cleaved form ANTITUMOR PROTEIN 06/07/23 Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Homo sapiens homo sapiens homo sapiens Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E. 2.6 X-RAY DIFFRACTION 0.224 0.190 True True unknown unknown unknown None None None None None 8cz8 B b 0 M protein NA mesothelin, cleaved form ANTITUMOR PROTEIN 06/07/23 Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics Homo sapiens homo sapiens homo sapiens Bandaranayake, A.D., Rupert, P.B., Lin, I., Pilat, K., Ruff, R.O., Friend, D.J., Chan, M.K., Clarke, M., Carter, J., Meshinchi, S., Mehlin, C., Olson, J.M., Strong, R.K., Correnti, C.E. 2.6 X-RAY DIFFRACTION 0.224 0.190 True True unknown unknown unknown None None None None None 8dis H L 0 d | D protein | protein NA | NA unknown | hemagglutinin ha2 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 CryoEM structure of Influenza A virus A/Melbourne/1/1946 (H1N1) hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8dis A C 0 e | E protein | protein NA | NA unknown | hemagglutinin ha2 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 CryoEM structure of Influenza A virus A/Melbourne/1/1946 (H1N1) hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8dis B G 0 f | F protein | protein NA | NA unknown | hemagglutinin ha2 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 CryoEM structure of Influenza A virus A/Melbourne/1/1946 (H1N1) hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7wt7 H D 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 1) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7wt8 H D 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7wt8 J I 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7wt9 H A 0 E protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 06/07/23 SARS-CoV-2 Omicron variant spike RBD in complex with Fab 9A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7x3y H L 0 B | C protein | protein NA | NA vp2 | vp3 VIRUS 01/08/09 Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 9A3 (CVB1-E:9A3) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.32 ELECTRON MICROSCOPY NA NA False False IGHV7 IGKV4 Kappa None None None None None 7xxh H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(11) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/07/23 Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11 Homo sapiens homo sapiens homo sapiens | homo sapiens Tan, Q., Li, B., Han, S., Zhao, Q., Wu, B. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y3g N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/07/23 Cryo-EM structure of a class A orphan GPCR Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, Z.J., Hua, T., Li, H., Zhang, J.Y., Luo, F. 2.77 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8a44 C D 0 A protein NA duffy binding protein CELL ADHESION 06/07/23 Plasmodium vivax Duffy binding protein region II bound the DARC ectodomain and monoclonal antibody DB1 Homo sapiens; Plasmodium vivax homo sapiens homo sapiens plasmodium vivax Moskovitz, R., Higgins, M.K. 2.49 X-RAY DIFFRACTION 0.225 0.196 False True IGHV5 IGKV1 Kappa None None None None None 8as2 H L 0 A | B protein | peptide NA | NA beta-arrestin-1 | c-c chemokine receptor type 5 SIGNALING PROTEIN 06/07/23 Structure of arrestin2 in complex with 4P CCR5 phosphopeptide and Fab30 Homo sapiens; Phage display vector pTDisp; SYNTHETIC CONSTRUCT phage display vector ptdisp phage display vector ptdisp homo sapiens | homo sapiens Isaikina, P., Jakob, R.P., Maier, T., Grzesiek, S. 3.2 X-RAY DIFFRACTION 0.316 0.280 False True IGHV3 IGKV1 Kappa None None None None None 8as3 H L 0 A | B protein | peptide NA | NA beta-arrestin-1 | c-c chemokine receptor type 5 SIGNALING PROTEIN 06/07/23 Structure of arrestin2 in complex with 6P CCR5 phosphopeptide and Fab30 Homo sapiens; Phage display vector pTDisp; SYNTHETIC CONSTRUCT phage display vector ptdisp phage display vector ptdisp homo sapiens | homo sapiens Isaikina, P., Jakob, R.P., Maier, T., Grzesiek, S. 3.5 X-RAY DIFFRACTION 0.333 0.285 False True IGHV3 IGKV1 Kappa None None None None None 8blq E C 0 D protein NA interleukin-13, human IMMUNE SYSTEM 06/07/23 Cryo-EM structure of the CODV-IL13-RefAb triple complex Homo sapiens homo sapiens homo sapiens homo sapiens Fernandez-Martinez, D., Kandiah, E. 3.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8blq A NA 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Cryo-EM structure of the CODV-IL13-RefAb triple complex Homo sapiens homo sapiens Fernandez-Martinez, D., Kandiah, E. 3.97 ELECTRON MICROSCOPY NA NA False True IGHV2 NA NA None None None None None 8blq NA B 0 D protein NA interleukin-13, human IMMUNE SYSTEM 06/07/23 Cryo-EM structure of the CODV-IL13-RefAb triple complex Homo sapiens homo sapiens homo sapiens Fernandez-Martinez, D., Kandiah, E. 3.97 ELECTRON MICROSCOPY NA NA False True NA IGKV15 Kappa None None None None None 8c7j A NA 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format Cricetulus griseus cricetulus griseus Adams, R., Macpherson, A. 2 X-RAY DIFFRACTION 0.226 0.186 False True IGHV3 NA NA None None None None None 8c7j NA B 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format Cricetulus griseus cricetulus griseus Adams, R., Macpherson, A. 2 X-RAY DIFFRACTION 0.226 0.186 False True NA IGKV1 Kappa None None None None None 8c7v A B 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format Cricetulus griseus cricetulus griseus cricetulus griseus Adams, R., Macpherson, A. 1.61 X-RAY DIFFRACTION 0.194 0.166 False True IGHV3 IGKV1 Kappa None None None None None 8c7v C D 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format Cricetulus griseus cricetulus griseus cricetulus griseus Adams, R., Macpherson, A. 1.61 X-RAY DIFFRACTION 0.194 0.166 False True IGHV3 IGKV1 Kappa None None None None None 8c7v E F 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Phage display derived serum albumin binding knob domain engineered within a novel VH framework 3 bispecific antibody format Cricetulus griseus cricetulus griseus cricetulus griseus Adams, R., Macpherson, A. 1.61 X-RAY DIFFRACTION 0.194 0.166 False True IGHV3 IGKV1 Kappa None None None None None 8cxg H L 0 A protein NA ankyrin repeat family a protein 2,envelope e protein VIRUS/IMMUNE SYSTEM 01/08/09 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Liu, W., Zhang, X.K., Gong, D.Y., Dai, X.H., Sharma, A., Zhang, T.H., Rey, F., Zhou, Z.H. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8cxg h l 0 C protein NA ankyrin repeat family a protein 2,envelope e protein VIRUS/IMMUNE SYSTEM 01/08/09 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Liu, W., Zhang, X.K., Gong, D.Y., Dai, X.H., Sharma, A., Zhang, T.H., Rey, F., Zhou, Z.H. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV3 Kappa None None None None None 8cxg 1 2 0 B protein NA ankyrin repeat family a protein 2,envelope e protein VIRUS/IMMUNE SYSTEM 01/08/09 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Liu, W., Zhang, X.K., Gong, D.Y., Dai, X.H., Sharma, A., Zhang, T.H., Rey, F., Zhou, Z.H. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8ejh H L 0 A protein NA glycoprotein g2 VIRAL PROTEIN 06/07/23 Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab Homo sapiens; Lassa mammarenavirus homo sapiens homo sapiens lassa mammarenavirus Perrett, H.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8ejh J K 0 C protein NA glycoprotein g2 VIRAL PROTEIN 06/07/23 Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab Homo sapiens; Lassa mammarenavirus homo sapiens homo sapiens lassa mammarenavirus Perrett, H.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 8ejh h l 0 B protein NA glycoprotein g2 VIRAL PROTEIN 06/07/23 Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab Homo sapiens; Lassa mammarenavirus homo sapiens homo sapiens lassa mammarenavirus Perrett, H.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV3 Kappa None None None None None 8eji H L 0 A protein NA glycoprotein g2 VIRAL PROTEIN 06/07/23 Lassa virus glycoprotein complex (Josiah) bound to 19.7E Fab Homo sapiens; Lassa mammarenavirus homo sapiens homo sapiens lassa mammarenavirus Perrett, H.R., Ward, A.B. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ejj H L 0 c protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab Homo sapiens; Lassa mammarenavirus homo sapiens homo sapiens lassa mammarenavirus Perrett, H.R., Ward, A.B. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 8ejj I J 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab Homo sapiens; Lassa mammarenavirus homo sapiens homo sapiens lassa mammarenavirus Perrett, H.R., Ward, A.B. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 8ejj h l 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 06/07/23 Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab Homo sapiens; Lassa mammarenavirus homo sapiens homo sapiens lassa mammarenavirus Perrett, H.R., Ward, A.B. 3.22 ELECTRON MICROSCOPY NA NA False False IGHV4 IGLV3 Lambda None None None None None 8ftg A NA 0 B Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8ftg B NA 0 B Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8ftg C NA 0 D Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8ftg D NA 0 D Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8ftg E NA 0 F Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8ftg F NA 0 F Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8ftg G NA 0 G Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8ftg H NA 0 G Hapten CFF CAFFEINE IMMUNE SYSTEM 06/07/23 Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody Lama glama lama glama lama glama Horn, J.R., Smith, C.A., Sonneson, G.J., Walter, R. 1.13 X-RAY DIFFRACTION 0.164 0.143 False True IGHV1 NA NA None None None None None 8g8w B NA 0 A protein NA mitochondrial brown fat uncoupling protein 1 MEMBRANE PROTEIN 06/07/23 Molecular mechanism of nucleotide inhibition of human uncoupling protein 1 Escherichia coli (strain K12); Homo sapiens; synthetic construct synthetic construct, escherichia coli (straink12) homo sapiens Gogoi, P., Jones, S.A., Ruprecht, J.J., King, M.S., Lee, Y., Zogg, T., Pardon, E., Chand, D., Steimle, S., Copeman, D., Cotrim, C.A., Steyaert, J., Crichton, P.G., Moiseenkova-Bell, V., Kunji, E.R.S. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8g8w C NA 0 A protein NA mitochondrial brown fat uncoupling protein 1 MEMBRANE PROTEIN 06/07/23 Molecular mechanism of nucleotide inhibition of human uncoupling protein 1 Escherichia coli (strain K12); Homo sapiens; synthetic construct synthetic construct, escherichia coli (straink12) homo sapiens Gogoi, P., Jones, S.A., Ruprecht, J.J., King, M.S., Lee, Y., Zogg, T., Pardon, E., Chand, D., Steimle, S., Copeman, D., Cotrim, C.A., Steyaert, J., Crichton, P.G., Moiseenkova-Bell, V., Kunji, E.R.S. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8gbv H L 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of PC39-17A, an anti-HIV broadly neutralizing antibody Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 2.08 X-RAY DIFFRACTION 0.230 0.193 False True IGHV4 IGKV3 Kappa None None None None None 8gbv A B 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of PC39-17A, an anti-HIV broadly neutralizing antibody Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 2.08 X-RAY DIFFRACTION 0.230 0.193 False True IGHV4 IGKV3 Kappa None None None None None 8gbw H L 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of PC39-23D, an anti-HIV broadly neutralizing antibody Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 1.5 X-RAY DIFFRACTION 0.201 0.182 False True IGHV4 IGKV3 Kappa None None None None None 8gbx H L 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of PC39-50I, an anti-HIV broadly neutralizing antibody Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.244 0.212 False True IGHV4 IGKV3 Kappa None None None None None 8gby H L 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of PC39-50E, an anti-HIV broadly neutralizing antibody Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 2.35 X-RAY DIFFRACTION 0.269 0.236 False True IGHV4 IGKV3 Kappa None None None None None 8gbz H L 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of PC39-55C, an anti-HIV broadly neutralizing antibody Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 1.97 X-RAY DIFFRACTION 0.265 0.219 False True IGHV4 IGKV3 Kappa None None None None None 8gc0 H L 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of PC39-50L, an anti-HIV broadly neutralizing antibody Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 2.43 X-RAY DIFFRACTION 0.252 0.211 False True IGHV4 IGKV3 Kappa None None None None None 8gc1 H L 0 NA NA NA NA IMMUNE SYSTEM 06/07/23 Crystal structure of the unmutated common ancestor (UCA) of the PC39-1 anti-HIV broadly neutralizing antibody lineage Homo sapiens homo sapiens homo sapiens Murrell, S., Omorodion, O., Wilson, I.A. 3.19 X-RAY DIFFRACTION 0.298 0.271 False True IGHV4 IGKV3 Kappa None None None None None 8irs E e 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/07/23 Dopamine Receptor D2R-Gi-Rotigotine complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Xu, P., Huang, S., Zhuang, Y., Mao, C., Zhang, Y., Wang, Y., Li, H., Jiang, Y., Zhang, Y., Xu, H.E. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8irt E e 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/07/23 Dopamine Receptor D3R-Gi-Rotigotine complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Xu, P., Huang, S., Zhuang, Y., Mao, C., Zhang, Y., Wang, Y., Li, H., Jiang, Y., Zhang, Y., Xu, H.E. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8slb H L 0 A protein NA cobalt/magnesium transport protein cora METAL TRANSPORT 06/07/23 X-ray structure of CorA N-terminal domain in complex with conformation-specific synthetic antibody C12 Homo sapiens; Thermotoga maritima MSB8 homo sapiens homo sapiens thermotoga maritima msb8 Dominik, P.K., Erramilli, S.K., Reddy, B.G., Kossiakoff, A.A. 2.04 X-RAY DIFFRACTION 0.218 0.166 False True IGHV3 IGKV1 Kappa None None None None None 8czz C D 0 B protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/INHIBITOR 05/31/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Pozharskiy, E., Tolbert, W., Pazgier, M. 3.14 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8czz G H 0 F protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/INHIBITOR 05/31/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Pozharskiy, E., Tolbert, W., Pazgier, M. 3.14 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8czz K L 0 J protein NA crf-1_ae t/f100 hiv-1 gp41 VIRAL PROTEIN/INHIBITOR 05/31/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Pozharskiy, E., Tolbert, W., Pazgier, M. 3.14 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 8czz M N 0 A protein NA crf01_ae t/f100 hiv-1 gp120 VIRAL PROTEIN/INHIBITOR 05/31/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Pozharskiy, E., Tolbert, W., Pazgier, M. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8czz O P 0 E protein NA crf01_ae t/f100 hiv-1 gp120 VIRAL PROTEIN/INHIBITOR 05/31/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Pozharskiy, E., Tolbert, W., Pazgier, M. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8czz Q R 0 I protein NA crf01_ae t/f100 hiv-1 gp120 VIRAL PROTEIN/INHIBITOR 05/31/23 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chen, Y., Pozharskiy, E., Tolbert, W., Pazgier, M. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 8hj5 C c 0 A protein NA guanine nucleotide-binding protein g(q) subunit alpha SIGNALING PROTEIN 05/31/23 Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16 Escherichia coli; Homo sapiens; Mus musculus; Vicugna pacos mus musculus homo sapiens Gan, B., Yu, L.Y., Ren, R.B. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hj5 E NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 05/31/23 Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16 Escherichia coli; Homo sapiens; Mus musculus; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Gan, B., Yu, L.Y., Ren, R.B. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8itf S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 05/31/23 Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. 3.46 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8itf N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/31/23 Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8iw9 S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 05/31/23 Cryo-EM structure of the CAD-bound mTAAR9-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. 3.08 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iw9 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/31/23 Cryo-EM structure of the CAD-bound mTAAR9-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7quh H L 0 A protein NA sialic acid-binding ig-like lectin 8 IMMUNE SYSTEM 05/31/23 Siglec-8 in complex with therapeutic Fab AK002. Homo sapiens homo sapiens homo sapiens homo sapiens Lenza, M.P., Oyenarte, I., Jimenez Barbero, J., Ereno Orbea, J. 2.867 X-RAY DIFFRACTION 0.284 0.225 False True IGHV3 IGKV3 Kappa None None None None None 7stf H L 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a alpha chain | kras g12v (7-16) IMMUNE SYSTEM 05/31/23 Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | synthetic construct Wright, K.M., Gabelli, S.B., Miller, M. 3.14 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7vzt B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 A human neutralizing antibody targeting SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, F.Z., Wang, Y., Tan, X.W., Shi, R., Yan, J.H. 3.41 X-RAY DIFFRACTION 0.263 0.218 False True IGHV3 IGLV6 Lambda None None None None None 7xeg C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2-Beta-RBD and CB6-092-Fab complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Feng, Y. 2.69 X-RAY DIFFRACTION 0.248 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7xeg E F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2-Beta-RBD and CB6-092-Fab complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Feng, Y. 2.69 X-RAY DIFFRACTION 0.248 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7xei C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2-prototyped-RBD and CB6-092-Fab complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Feng, Y. 2.76 X-RAY DIFFRACTION 0.263 0.215 False True IGHV3 IGKV1 Kappa None None None None None 7xei E F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2-prototyped-RBD and CB6-092-Fab complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, Y., Feng, Y. 2.76 X-RAY DIFFRACTION 0.263 0.215 False True IGHV3 IGKV1 Kappa None None None None None 7xjf A B 0 C protein NA leukocyte surface antigen cd47 IMMUNE SYSTEM 05/31/23 Crystal structure of 6MW3211 Fab in complex with CD47 Homo sapiens homo sapiens homo sapiens homo sapiens Wang, J., Wang, R., Jiao, S., Wang, S., Zhang, J., Zhang, M., Wang, M. 2.6 X-RAY DIFFRACTION 0.231 0.187 False True IGHV1 IGKV1 Kappa None None None None None 7xld B NA 0 A protein NA iron-regulated surface determinant protein h METAL TRANSPORT 05/31/23 Crystal structure of IsdH linker-NEAT3 bound to a nanobody (VHH) Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Caaveiro, J.M.M., Valenciano-Bellido, S., Tsumoto, K. 1.65 X-RAY DIFFRACTION 0.197 0.148 False True IGHV1 NA NA None None None None None 7xli B NA 0 A protein NA fur-regulated protein b METAL TRANSPORT 05/31/23 Crystal structure of IsdB linker-NEAT2 bound to a nanobody (VHH) Lama glama; Staphylococcus aureus lama glama staphylococcus aureus Caaveiro, J.M.M., Valenciano-Bellido, S., Tsumoto, K. 1.7 X-RAY DIFFRACTION 0.237 0.209 False True IGHV1 NA NA None None None None None 7xwo E e 0 F | C protein | protein NA | NA g324 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/31/23 Neurokinin A bound to active human neurokinin 2 receptor in complex with G324 Bos taurus; Homo sapiens; Rattus norvegicus rattus norvegicus homo sapiens | rattus norvegicus Sun, W.J., Yuan, Q.N., Zhang, H.H., Yang, F., Ling, S.L., Lv, P., Eric, X., Tian, C.L., Yin, W.C., Shi, P. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dww H L 0 N protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.A08 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dww V U 0 M protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.A08 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dww X W 0 O protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.A08 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dww Z Y 0 P protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.A08 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dwx H L 0 P protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.C01 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.27 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dwx V U 0 M protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.C01 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.27 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dwx X W 0 N protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.C01 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.27 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dwx Z Y 0 O protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab 506.C01 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.27 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dwy H L 0 P protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab CHK-265 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.18 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 8dwy V U 0 M protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab CHK-265 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.18 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 8dwy X W 0 N protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab CHK-265 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.18 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 8dwy Z Y 0 O protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Chikungunya VLP in complex with neutralizing Fab CHK-265 (asymmetric unit) Chikungunya virus strain Senegal 37997; Homo sapiens homo sapiens homo sapiens chikungunya virus strain senegal 37997 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.18 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 8ee0 H L 0 A protein NA 6-deoxyerythronolide b synthase BIOSYNTHETIC PROTEIN, TRANSFERASE/IMMUNE SYSTEM 05/31/23 KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2 Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Brodsky, K.L., Guzman, K.M., Mathews, I.I., Khosla, C. 2.65 X-RAY DIFFRACTION 0.254 0.211 False True IGHV3 IGKV2 Kappa None None None None None 8ee1 B C 0 A protein NA 6-deoxyerythronolide b synthase BIOSYNTHETIC PROTEIN, TRANSFERASE/IMMUNE SYSTEM 05/31/23 KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment AA5 Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Brodsky, K.L., Guzman, K.M., Mathews, I.I., Khosla, C. 2.7 X-RAY DIFFRACTION 0.254 0.225 False True IGHV4 IGKV3 Kappa None None None None None 8ee1 G H 0 D protein NA 6-deoxyerythronolide b synthase BIOSYNTHETIC PROTEIN, TRANSFERASE/IMMUNE SYSTEM 05/31/23 KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment AA5 Homo sapiens; Saccharopolyspora erythraea homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Brodsky, K.L., Guzman, K.M., Mathews, I.I., Khosla, C. 2.7 X-RAY DIFFRACTION 0.254 0.225 False True IGHV4 IGKV3 Kappa None None None None None 8fk5 H L 0 I | G | C protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN 01/08/09 Cryo-EM Structure of PG9RSH DU011 Fab in complex with BG505 DS-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8fl1 H L 0 I | G | C protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN 01/08/09 Cryo-EM Structure of PG9RSH DU025 Fab in complex with BG505 DS-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 8flw H L 0 I | G | C protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN 05/31/23 Cryo-EM Structure of PGT145 DU303 Fab in complex with BG505 DS-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8g30 E F 0 M protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g30 G I 0 N protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g30 H L 0 O protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g30 J K 0 P protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3m E F 0 G protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3m A D 0 J protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3m C I 0 L protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3n E F 0 G protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H., Snell, G. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3n A D 0 J protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H., Snell, G. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3n B H 0 K protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H., Snell, G. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3n C I 0 L protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H., Snell, G. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3o E F 0 H protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3o A D 0 G protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3o C I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3p C I 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3p F J 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3p G K 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3p H L 0 E protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI9 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3q C B 0 G protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI17 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3q I D 0 E protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI17 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3q A L 0 F protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI17 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3r C B 0 G protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Tanzania/205/2010 H3N2 with S245N S247T mutations in complex with one FNI17 Fab molecule Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3v A L 0 G protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3v B M 0 H protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3v C N 0 I protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3v D O 0 J protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3z H L 0 C protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Neuraminidase of B/Massachusetts/02/2012 (Yamagata) in complex with 4 FNI17 Fab molecules Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3z E F 0 D protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Neuraminidase of B/Massachusetts/02/2012 (Yamagata) in complex with 4 FNI17 Fab molecules Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3z G I 0 A protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Neuraminidase of B/Massachusetts/02/2012 (Yamagata) in complex with 4 FNI17 Fab molecules Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g3z J K 0 B protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 Neuraminidase of B/Massachusetts/02/2012 (Yamagata) in complex with 4 FNI17 Fab molecules Homo sapiens; Influenza B virus homo sapiens homo sapiens influenza b virus Dang, H.V., Snell, G. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g40 A L 0 G protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g40 B M 0 H protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8g40 C N 0 I protein NA neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI19 Fab molecules Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Dang, H.V., Snell, G. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8gnk H L 0 A protein NA sodium- and chloride-dependent gaba transporter 1 MEMBRANE PROTEIN 05/31/23 CryoEM structure of cytosol-facing, substrate-bound ratGAT1 Mus musculus; Rattus norvegicus mus musculus mus musculus rattus norvegicus Nayak, S.R., Joseph, D., Penmatsa, A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8h07 E J 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.4 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h07 N O 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.4 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h07 G H 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.4 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h07 I K 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.4 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h07 M P 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.4 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h07 Q R 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.4 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h08 D J 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.1 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h08 N O 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.1 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h08 F H 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.1 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h08 I K 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.1 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h08 L P 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.1 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h08 Q R 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/31/23 SARS-CoV-2 BA.1 variants S ectodomain trimer in complex with neutralizing antibody 10-5B and 6-2C Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8iw1 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(olf) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/31/23 Cryo-EM structure of the PEA-bound mTAAR9-Golf complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iw4 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/31/23 Cryo-EM structure of the SPE-bound mTAAR9-Gs complex Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | homo sapiens Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. 3.49 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8iw7 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein subunit alpha isoformsshort | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/31/23 Cryo-EM structure of the PEA-bound mTAAR9-Gs complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT escherichia coli bl21(de3) homo sapiens | homo sapiens Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8op0 A NA 0 B peptide NA tau phf6 peptide IMMUNE SYSTEM 05/31/23 VHH Z70 mutant 20 in interaction with PHF6 Tau peptide Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens Dupre, E., Mortelecque, J., NGuyen, M., Hanoulle, X., Landrieu, I. 1.54 X-RAY DIFFRACTION 0.197 0.160 False True IGHV3 NA NA None None None None None 8opi A NA 0 B peptide NA phf6 tau peptide IMMUNE SYSTEM 05/31/23 VHH Z70 mutant 1 in interaction with PHF6 Tau peptide Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens Dupre, E., Mortelecque, J., NGuyen, M., Hanoulle, X., Landrieu, I. 1.83 X-RAY DIFFRACTION 0.230 0.198 False True IGHV3 NA NA None None None None None 8go8 H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8go8 I M 0 B | U protein | peptide NA | NA beta-arrestin-1 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8goc D E 0 A | G protein | peptide NA | NA beta-arrestin-2 | vasopressin v2 receptor SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8goc H L 0 B | U protein | peptide NA | NA beta-arrestin-2 | vasopressin v2 receptor SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8goc M N 0 C | V protein | peptide NA | NA beta-arrestin-2 | vasopressin v2 receptor SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8goo D E 0 A | G protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8goo H L 0 B | U protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8goo M N 0 C | V protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gp3 H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | c-x-c chemokine receptor type 4 SIGNALING PROTEIN 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gp3 I M 0 B | U protein | peptide NA | NA beta-arrestin-1 | c-x-c chemokine receptor type 4 SIGNALING PROTEIN 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i0n H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine) Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i0n I M 0 B | U protein | peptide NA | NA beta-arrestin-1 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine) Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i0q H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 (Local refine) Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i0q I M 0 B | U protein | peptide NA | NA beta-arrestin-1 | c-x-c chemokine receptor type 4 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 (Local refine) Mus musculus; Rattus norvegicus; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i0z D E 0 A | G protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.33 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i0z H L 0 B | U protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.33 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i0z M N 0 C | V protein | peptide NA | NA beta-arrestin-2 | c5a anaphylatoxin chemotactic receptor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 4.33 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i10 D E 0 A | G protein | peptide NA | NA beta-arrestin-2 | vasopressin v2 receptor SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R (Local refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i10 H L 0 B | U protein | peptide NA | NA beta-arrestin-2 | vasopressin v2 receptor SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R (Local refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8i10 M N 0 C | V protein | peptide NA | NA beta-arrestin-2 | vasopressin v2 receptor SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R (Local refine) Bos taurus; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | homo sapiens Maharana, J., Sarma, P., Yadav, M.K., Banerjee, R., Shukla, A.K. 3.96 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7qt0 A B 0 A Hapten FD0 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid IMMUNE SYSTEM 05/24/23 Antibody FenAb136 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 2.07 X-RAY DIFFRACTION 0.282 0.242 False True IGHV1 IGKV6 Kappa None None None None None 7qt0 C D 0 C Hapten FD0 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid IMMUNE SYSTEM 05/24/23 Antibody FenAb136 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 2.07 X-RAY DIFFRACTION 0.282 0.242 False True IGHV1 IGKV6 Kappa None None None None None 7qt0 E F 0 E Hapten FD0 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid IMMUNE SYSTEM 05/24/23 Antibody FenAb136 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 2.07 X-RAY DIFFRACTION 0.282 0.242 False True IGHV1 IGKV6 Kappa None None None None None 7qt0 G H 0 G Hapten FD0 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid IMMUNE SYSTEM 05/24/23 Antibody FenAb136 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 2.07 X-RAY DIFFRACTION 0.282 0.242 False True IGHV1 IGKV6 Kappa None None None None None 7qt0 I J 0 I Hapten FD0 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid IMMUNE SYSTEM 05/24/23 Antibody FenAb136 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 2.07 X-RAY DIFFRACTION 0.282 0.242 False True IGHV1 IGKV6 Kappa None None None None None 7qt0 K L 0 K Hapten FD0 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid IMMUNE SYSTEM 05/24/23 Antibody FenAb136 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 2.07 X-RAY DIFFRACTION 0.282 0.242 False True IGHV1 IGKV6 Kappa None None None None None 7qt2 A B 0 A Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 05/24/23 Antibody FenAb208 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 1.92 X-RAY DIFFRACTION 0.230 0.195 False True IGHV1 IGKV6 Kappa None None None None None 7qt2 C D 0 C Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 05/24/23 Antibody FenAb208 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 1.92 X-RAY DIFFRACTION 0.230 0.195 False True IGHV1 IGKV6 Kappa None None None None None 7qt3 A B 0 B Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 05/24/23 Antibody FenAb609 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 1.7 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 IGKV6 Kappa None None None None None 7qt3 C D 0 C Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 05/24/23 Antibody FenAb609 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 1.7 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 IGKV6 Kappa None None None None None 7qt4 A B 0 A Hapten FD0 2-[2-[2-[2-[[5-oxidanylidene-5-[2-[4-[phenyl(propanoyl)amino]piperidin-1-yl]ethylamino]pentanoyl]amino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid IMMUNE SYSTEM 05/24/23 Antibody FenAb709 - fentanyl complex Mus musculus mus musculus mus musculus mus musculus Zeelen, J.P., Straaten van, M., Stebbins, C.E. 2.32 X-RAY DIFFRACTION 0.248 0.209 False True IGHV1 IGKV6 Kappa None None None None None 7xsc A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-2B10 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z., Lin, Z. 2.88 X-RAY DIFFRACTION 0.250 0.200 False True IGHV3 IGKV1 Kappa None None None None None 7xsc D H 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-2B10 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z., Lin, Z. 2.88 X-RAY DIFFRACTION 0.250 0.200 False True IGHV3 IGKV1 Kappa None None None None None 7y1f E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 05/24/23 Cryo-EM structure of human k-opioid receptor-Gi complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Chen, B.O., Xu, F.E. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ahn H L 0 A protein NA envelope polyprotein VIRAL PROTEIN 05/24/23 Sin Nombre virus Gn in complex with Fab SNV-42 Homo sapiens; Sin Nombre orthohantavirus homo sapiens homo sapiens sin nombre orthohantavirus Stass, R., Bowden, T.A. 1.8 X-RAY DIFFRACTION 0.221 0.190 False True IGHV3 IGLV1 Lambda None None None None None 8av9 H L 0 A protein NA induced myeloid leukemia cell differentiation protein mcl-1 APOPTOSIS 05/24/23 INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Hargreaves, D. 1.99 X-RAY DIFFRACTION 0.272 0.223 False True IGHV3 IGLV1 Lambda None None None None None 8bs8 H L 0 NA NA NA NA IMMUNE SYSTEM 05/24/23 Bovine naive ultralong antibody AbD08 collected at 100K Bos taurus bos taurus bos taurus Clarke, J.D., Douangamath, A., Mikolajek, H., Stuart, D.I., Owens, R.J. 1.59 X-RAY DIFFRACTION 0.219 0.175 False True IGHV1 IGLV1 Lambda None None None None None 8cif H L 0 NA NA NA NA IMMUNE SYSTEM 05/24/23 Bovine naive ultralong antibody AbD08 collected at 293K Bos taurus bos taurus bos taurus Clarke, J.D., Mikolajek, H., Stuart, D.I., Owens, R.J. 2.2 X-RAY DIFFRACTION 0.228 0.177 False True IGHV1 IGLV1 Lambda None None None None None 8cwi H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Fab arm of antibody 10G4 bound to CoV-2 receptor binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 1.873 X-RAY DIFFRACTION 0.205 0.170 False True IGHV3 IGKV1 Kappa None None None None None 8cwj H L 0 G protein NA spike glycoprotein IMMUNE SYSTEM 05/24/23 Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD) Homo sapiens; Pangolin coronavirus homo sapiens homo sapiens pangolin coronavirus Langley, D.B., Christ, D. 2.449 X-RAY DIFFRACTION 0.230 0.196 False True IGHV5 IGKV4 Kappa None None None None None 8cwj A B 0 I protein NA spike glycoprotein IMMUNE SYSTEM 05/24/23 Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD) Homo sapiens; Pangolin coronavirus homo sapiens homo sapiens pangolin coronavirus Langley, D.B., Christ, D. 2.449 X-RAY DIFFRACTION 0.230 0.196 False True IGHV5 IGKV4 Kappa None None None None None 8cwj J K 0 G protein NA spike glycoprotein IMMUNE SYSTEM 05/24/23 Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD) Homo sapiens; Pangolin coronavirus homo sapiens homo sapiens pangolin coronavirus Langley, D.B., Christ, D. 2.449 X-RAY DIFFRACTION 0.230 0.196 False True IGHV3 IGKV1 Kappa None None None None None 8cwj U V 0 I protein NA spike glycoprotein IMMUNE SYSTEM 05/24/23 Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD) Homo sapiens; Pangolin coronavirus homo sapiens homo sapiens pangolin coronavirus Langley, D.B., Christ, D. 2.449 X-RAY DIFFRACTION 0.230 0.196 False True IGHV3 IGKV1 Kappa None None None None None 8cwk H L 0 C protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Fab arm of antibodies 4G1-C2 and 10G4 bound to CoV-2 receptor binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.368 X-RAY DIFFRACTION 0.223 0.186 False True IGHV3 IGKV1 Kappa None None None None None 8cwk A B 0 C protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Fab arm of antibodies 4G1-C2 and 10G4 bound to CoV-2 receptor binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.368 X-RAY DIFFRACTION 0.223 0.186 False True IGHV3 IGKV1 Kappa None None None None None 8dnn B C 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 05/24/23 Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Muthuraman, K., Kucharska, I., Ivanochko, D., Julien, J.P. 3.12 X-RAY DIFFRACTION 0.252 0.193 False True IGHV1 IGKV4 Kappa None None None None None 8dnn E F 0 D protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 05/24/23 Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Muthuraman, K., Kucharska, I., Ivanochko, D., Julien, J.P. 3.12 X-RAY DIFFRACTION 0.252 0.193 False True IGHV1 IGKV4 Kappa None None None None None 8eit E e 0 A | B protein | protein NA | NA a modified guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/23 Structure of FFAR1-Gq complex bound to DHA Homo sapiens; Tequatrovirus T4 homo sapiens homo sapiens | homo sapiens Kumari, P., Inoue, A., Chapman, K., Lian, P., Rosenbaum, D.M. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ejc E e 0 A | B protein | protein NA | NA a modified guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/23 Structure of FFAR1-Gq complex bound to TAK-875 Homo sapiens homo sapiens homo sapiens | homo sapiens Kumari, P., Inoue, A., Chapman, K., Lian, P., Rosenbaum, D.M. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ejk E e 0 A | C | B protein | protein | protein NA | NA | NA a modified guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/23 Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Kumari, P., Inoue, A., Chapman, K., Lian, P., Rosenbaum, D.M. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8f60 A B 0 C protein NA b- and t-lymphocyte attenuator IMMUNE SYSTEM 05/24/23 anti-BTLA monoclonal antibody r23C8 in complex with BTLA Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Hendle, J., Atwell, S., Lieu, R., Hickey, M., Weichert, K. 1.64 X-RAY DIFFRACTION 0.205 0.181 False True IGHV1 IGKV1 Kappa None None None None None 8f6l A B 0 C protein NA b- and t-lymphocyte attenuator IMMUNE SYSTEM 05/24/23 anti-BTLA monoclonal antibody h25F7 in complex with BTLA Homo sapiens homo sapiens homo sapiens homo sapiens Hendle, J., Atwell, S., Lieu, R., Hickey, M., Weichert, K. 1.85 X-RAY DIFFRACTION 0.240 0.198 False True IGHV1 IGKV4 Kappa None None None None None 8f6o A B 0 C protein NA b- and t-lymphocyte attenuator IMMUNE SYSTEM 05/24/23 anti-BTLA monoclonal antibody h22B3 in complex with BTLA Homo sapiens homo sapiens homo sapiens homo sapiens Hendle, J., Atwell, S., Lieu, R., Hickey, M., Weichert, K. 2.31 X-RAY DIFFRACTION 0.266 0.215 False True IGHV1 IGKV3 Kappa None None None None None 8fo3 NA A 0 A Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA B 0 A Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA C 0 C Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA D 0 C Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA G 0 G Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA H 0 G Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA I 0 I Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA J 0 I Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA E 0 E Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA F 0 E Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA K 0 K Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo3 NA L 0 K Hapten Y4K 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazinyl}benzene-1-sulfonamide IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.280 0.229 False True NA IGLV2 Lambda None None None None None 8fo4 NA A 0 A Hapten Y4Q 6-methyl-2-{2-[(1E)-3-(2-nitrophenyl)prop-1-en-1-yl]hydrazinyl}pyrimidin-4(5H)-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.238 0.186 False True NA IGLV2 Lambda None None None None None 8fo4 NA B 0 A Hapten Y4Q 6-methyl-2-{2-[(1E)-3-(2-nitrophenyl)prop-1-en-1-yl]hydrazinyl}pyrimidin-4(5H)-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.238 0.186 False True NA IGLV2 Lambda None None None None None 8fo4 NA C 0 D Hapten Y4Q 6-methyl-2-{2-[(1E)-3-(2-nitrophenyl)prop-1-en-1-yl]hydrazinyl}pyrimidin-4(5H)-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.238 0.186 False True NA IGLV2 Lambda None None None None None 8fo4 NA D 0 D Hapten Y4Q 6-methyl-2-{2-[(1E)-3-(2-nitrophenyl)prop-1-en-1-yl]hydrazinyl}pyrimidin-4(5H)-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2 X-RAY DIFFRACTION 0.238 0.186 False True NA IGLV2 Lambda None None None None None 8fo5 NA A 0 A Hapten Y4U 1-[1-(benzenesulfonyl)-1H-pyrrol-3-yl]ethan-1-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 1-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethan-1-one Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.89 X-RAY DIFFRACTION 0.250 0.201 False True NA IGLV2 Lambda None None None None None 8fo5 NA B 0 A Hapten Y4U 1-[1-(benzenesulfonyl)-1H-pyrrol-3-yl]ethan-1-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 1-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethan-1-one Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.89 X-RAY DIFFRACTION 0.250 0.201 False True NA IGLV2 Lambda None None None None None 8fo5 NA C 0 C Hapten Y4U 1-[1-(benzenesulfonyl)-1H-pyrrol-3-yl]ethan-1-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 1-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethan-1-one Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.89 X-RAY DIFFRACTION 0.250 0.201 False True NA IGLV2 Lambda None None None None None 8fo5 NA D 0 C Hapten Y4U 1-[1-(benzenesulfonyl)-1H-pyrrol-3-yl]ethan-1-one IMMUNE SYSTEM 05/24/23 Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 1-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethan-1-one Homo sapiens homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.89 X-RAY DIFFRACTION 0.250 0.201 False True NA IGLV2 Lambda None None None None None 8g6i C B 0 A protein NA coagulation factor viii chimera from human and pig BLOOD CLOTTING 05/24/23 Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor Homo sapiens; Sus scrofa homo sapiens homo sapiens sus scrofa, homo sapiens Childers, K.C., Davulcu, O., Haynes, R.M., Lollar, P., Doering, C.B., Coxon, C.H., Spiegel, P.C. 4.23 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8gb5 B C 0 A protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 25F9 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.35 X-RAY DIFFRACTION 0.320 0.275 False True IGHV3 IGLV1 Lambda None None None None None 8gb5 F E 0 D protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 25F9 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.35 X-RAY DIFFRACTION 0.320 0.275 False True IGHV3 IGLV1 Lambda None None None None None 8gb5 I H 0 G protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 25F9 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.35 X-RAY DIFFRACTION 0.320 0.275 False True IGHV3 IGLV1 Lambda None None None None None 8gb5 L K 0 J protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 25F9 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.35 X-RAY DIFFRACTION 0.320 0.275 False True IGHV3 IGLV1 Lambda None None None None None 8gb6 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 21B6 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.221 0.182 False True IGHV3 IGKV1 Kappa None None None None None 8gb7 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 20A7 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.57 X-RAY DIFFRACTION 0.245 0.204 False True IGHV3 IGKV3 Kappa None None None None None 8gb8 H L 0 E protein NA spike protein s1 IMMUNE SYSTEM 05/24/23 Crystal structure of SARS-CoV-2 BA.2 receptor binding domain in complex with neutralizing antibody 20A7 Macaca mulatta; Severe acute respiratory syndrome coronavirus 2 macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.228 0.200 False True IGHV3 IGKV3 Kappa None None None None None 8ghv S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/23 Cannabinoid Receptor 1-G Protein Complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Krishna Kumar, K., Robertson, M.J., Skiniotis, G., Kobilka, B.K. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ia8 S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 05/24/23 Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Liao, Q., Chen, G., Du, Y., Ye, R.D. 2.86 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7st5 H L 0 A protein NA tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 05/17/23 Structure of Fab CC-95251 in complex with SIRP-alpha Homo sapiens homo sapiens homo sapiens homo sapiens Fenalti, G. 2.2 X-RAY DIFFRACTION 0.280 0.245 False True IGHV1 IGKV1 Kappa None None None None None 7st5 h l 0 F protein NA tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 05/17/23 Structure of Fab CC-95251 in complex with SIRP-alpha Homo sapiens homo sapiens homo sapiens homo sapiens Fenalti, G. 2.2 X-RAY DIFFRACTION 0.280 0.245 False False IGHV1 IGKV1 Kappa None None None None None 7trk H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Vuckovic, Z., Mobbs, J.I., Belousoff, M.J., Glukhova, A., Sexton, P.M., Danev, R., Thal, D.M. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7trp H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Vuckovic, Z., Mobbs, J.I., Belousoff, M.J., Glukhova, A., Sexton, P.M., Danev, R., Thal, D.M. 2.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7trq H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Vuckovic, Z., Mobbs, J.I., Belousoff, M.J., Glukhova, A., Sexton, P.M., Danev, R., Thal, D.M. 2.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7trs H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/17/23 Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Vuckovic, Z., Mobbs, J.I., Belousoff, M.J., Glukhova, A., Sexton, P.M., Danev, R., Thal, D.M. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yru H L 0 A protein NA activin receptor type-1 TRANSFERASE/IMMUNE SYSTEM 05/17/23 ALK2 antibody complex Homo sapiens; Rattus norvegicus rattus norvegicus rattus norvegicus homo sapiens Kawaguchi, Y., Nakamura, K., Suzuki, M., Tsuji, S., Katagiri, T. 2.6 X-RAY DIFFRACTION 0.271 0.245 False True IGHV5 IGKV4 Kappa None None None None None 7zqt C D 0 A protein NA adhesin binding fucosylated histo-blood group antigen CELL ADHESION 05/17/23 Helicobacter pylori adhesin BabA bound to neutralising human antibody. Helicobacter pylori; Homo sapiens; Lama glama homo sapiens homo sapiens helicobacter pylori Moonens, K., Boren, T. 2.7 X-RAY DIFFRACTION 0.281 0.225 False True IGHV3 IGKV1 Kappa None None None None None 7zqt G H 0 E protein NA adhesin binding fucosylated histo-blood group antigen CELL ADHESION 05/17/23 Helicobacter pylori adhesin BabA bound to neutralising human antibody. Helicobacter pylori; Homo sapiens; Lama glama homo sapiens homo sapiens helicobacter pylori Moonens, K., Boren, T. 2.7 X-RAY DIFFRACTION 0.281 0.225 False True IGHV3 IGKV1 Kappa None None None None None 7zqt B NA 0 A protein NA adhesin binding fucosylated histo-blood group antigen CELL ADHESION 05/17/23 Helicobacter pylori adhesin BabA bound to neutralising human antibody. Helicobacter pylori; Homo sapiens; Lama glama lama glama helicobacter pylori Moonens, K., Boren, T. 2.7 X-RAY DIFFRACTION 0.281 0.225 False True IGHV1 NA NA None None None None None 7zqt F NA 0 E protein NA adhesin binding fucosylated histo-blood group antigen CELL ADHESION 05/17/23 Helicobacter pylori adhesin BabA bound to neutralising human antibody. Helicobacter pylori; Homo sapiens; Lama glama lama glama helicobacter pylori Moonens, K., Boren, T. 2.7 X-RAY DIFFRACTION 0.281 0.225 False True IGHV1 NA NA None None None None None 8bse H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/17/23 CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN (RBD) in complex with 1D1 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Welin, M., Kimbung, Y.R., Focht, D., Pisitkun, T. 1.9 X-RAY DIFFRACTION 0.216 0.177 False True IGHV3 IGKV1 Kappa None None None None None 8bsf H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/17/23 CRYSTAL STRUCTURE OF SARS-COV-2 RECEPTOR BINDING DOMAIN (RBD-beta variant) in complex with 3D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Welin, M., Kimbung, Y.R., Focht, D., Pisitkun, T. 2.2 X-RAY DIFFRACTION 0.229 0.196 False True IGHV5 IGLV1 Lambda None None None None None 8csj H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of NTD-directed non-neutralizing antibody 4-33 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV7 IGLV1 Lambda None None None None None 8csj D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of NTD-directed non-neutralizing antibody 4-33 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV7 IGLV1 Lambda None None None None None 8csj F G 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of NTD-directed non-neutralizing antibody 4-33 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.53 ELECTRON MICROSCOPY NA NA False True IGHV7 IGLV1 Lambda None None None None None 8dn6 C D 0 A protein NA protein toc75-3, chloroplastic MEMBRANE PROTEIN 05/17/23 The crystal structure of the Arabidopsis thaliana Toc75 POTRA domains in complex with fab tc2 Arabidopsis thaliana; synthetic construct synthetic construct synthetic construct arabidopsis thaliana Srinivasan, K., Noinaj, N. 3 X-RAY DIFFRACTION 0.293 0.240 False True IGHV3 IGKV1 Kappa None None None None None 8dn6 E F 0 B protein NA protein toc75-3, chloroplastic MEMBRANE PROTEIN 05/17/23 The crystal structure of the Arabidopsis thaliana Toc75 POTRA domains in complex with fab tc2 Arabidopsis thaliana; synthetic construct synthetic construct synthetic construct arabidopsis thaliana Srinivasan, K., Noinaj, N. 3 X-RAY DIFFRACTION 0.293 0.240 False True IGHV3 IGKV1 Kappa None None None None None 8dn7 D H 0 E protein NA protein toc75, chloroplastic Membrane Protein/Immune System 05/17/23 The crystal structure of the Pisum sativum Toc75 POTRA domains in complex with fab ax9 Pisum sativum; synthetic construct synthetic construct synthetic construct pisum sativum Srinivasan, K., Noinaj, N. 2 X-RAY DIFFRACTION 0.259 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8dn7 A B 0 C protein NA protein toc75, chloroplastic Membrane Protein/Immune System 05/17/23 The crystal structure of the Pisum sativum Toc75 POTRA domains in complex with fab ax9 Pisum sativum; synthetic construct synthetic construct synthetic construct pisum sativum Srinivasan, K., Noinaj, N. 2 X-RAY DIFFRACTION 0.259 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8hn6 A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/17/23 Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qi, J., Chen, Y. 2.07 X-RAY DIFFRACTION 0.214 0.192 False True IGHV3 IGKV1 Kappa None None None None None 8hn6 C D 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/17/23 Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qi, J., Chen, Y. 2.07 X-RAY DIFFRACTION 0.214 0.192 False True IGHV3 IGKV1 Kappa None None None None None 8hn7 B A 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/17/23 Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qi, J., Chen, Y. 3 X-RAY DIFFRACTION 0.263 0.232 False True IGHV3 IGKV3 Kappa None None None None None 8hn7 D C 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/17/23 Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Qi, J., Chen, Y. 3 X-RAY DIFFRACTION 0.263 0.232 False True IGHV3 IGKV3 Kappa None None None None None 7xrz H L 0 X protein NA soluble cytochrome b562 IMMUNE SYSTEM 05/10/23 Crystal structure of BRIL and SRP2070_Fab complex Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Suzuki, M., Miyagi, H., Yasunaga, M., Asada, H., Iwata, S., Saito, J. 2.1 X-RAY DIFFRACTION 0.268 0.214 False False IGHV1 IGKV5 Kappa None None None None None 7xrz B A 0 Y protein NA soluble cytochrome b562 IMMUNE SYSTEM 05/10/23 Crystal structure of BRIL and SRP2070_Fab complex Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Suzuki, M., Miyagi, H., Yasunaga, M., Asada, H., Iwata, S., Saito, J. 2.1 X-RAY DIFFRACTION 0.268 0.214 False False IGHV1 IGKV5 Kappa None None None None None 7xsa B C 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/10/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P2S-2E9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.2 X-RAY DIFFRACTION 0.283 0.231 False True IGHV2 IGLV2 Lambda None None None None None 7xsa H I 0 J protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/10/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P2S-2E9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.2 X-RAY DIFFRACTION 0.283 0.231 False True IGHV2 IGLV2 Lambda None None None None None 7xsb H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/10/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-3B11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z., Gao, M. 3.2 X-RAY DIFFRACTION 0.324 0.258 False True IGHV3 IGLV6 Lambda None None None None None 7xsb D F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/10/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-3B11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z., Gao, M. 3.2 X-RAY DIFFRACTION 0.324 0.258 False True IGHV3 IGLV6 Lambda None None None None None 7xsb G I 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/10/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-3B11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z., Gao, M. 3.2 X-RAY DIFFRACTION 0.324 0.258 False True IGHV3 IGLV6 Lambda None None None None None 7xsb J K 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/10/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-3B11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z., Gao, M. 3.2 X-RAY DIFFRACTION 0.324 0.258 False True IGHV3 IGLV6 Lambda None None None None None 8a99 R O 0 A protein NA sars-cov2 spike 1-up conformation in complex with fab47 VIRAL PROTEIN 05/10/23 SARS Cov2 Spike in 1-up conformation complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8a99 S P 0 B protein NA sars-cov2 spike 1-up conformation in complex with fab47 VIRAL PROTEIN 05/10/23 SARS Cov2 Spike in 1-up conformation complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8a99 T Q 0 C protein NA sars-cov2 spike 1-up conformation in complex with fab47 VIRAL PROTEIN 05/10/23 SARS Cov2 Spike in 1-up conformation complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8cbx H L 0 NA NA NA NA IMMUNE SYSTEM 05/10/23 Crystal Structure of Anti-Cortisol Fab fragment Mus musculus mus musculus mus musculus Eronen, V., Rouvinen, J., Hakulinen, N. 2 X-RAY DIFFRACTION 0.239 0.223 False True IGHV5 IGKV4 Kappa None None None None None 8cby H L 0 H Hapten HCY (11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE IMMUNE SYSTEM 05/10/23 Crystal Structure of Anti-cortisol Fab in Complex with Cortisol Mus musculus mus musculus mus musculus mus musculus Eronen, V., Rouvinen, J., Hakulinen, N. 2.27 X-RAY DIFFRACTION 0.230 0.202 False True IGHV5 IGKV4 Kappa None None None None None 8cbz H L 0 H Hapten C0R CORTICOSTERONE IMMUNE SYSTEM 05/10/23 Crystal Structure of Anti-cortisol Fab in Complex with Corticosterone Mus musculus mus musculus mus musculus mus musculus Eronen, V., Rouvinen, J., Hakulinen, N. 1.86 X-RAY DIFFRACTION 0.213 0.204 False True IGHV5 IGKV4 Kappa None None None None None 8cc0 H L 0 H Hapten UQC Cortisone IMMUNE SYSTEM 05/10/23 Crystal Structure of Anti-cortisol Fab in Complex with Cortisone Mus musculus mus musculus mus musculus mus musculus Eronen, V., Rouvinen, J., Hakulinen, N. 1.85 X-RAY DIFFRACTION 0.209 0.191 False True IGHV5 IGKV4 Kappa None None None None None 8cc1 H L 0 H Hapten TUA prednisolone IMMUNE SYSTEM 05/10/23 Crystal Structure of Anti-cortisol Fab in Complex with Prednisolone Mus musculus mus musculus mus musculus mus musculus Eronen, V., Rouvinen, J., Hakulinen, N. 2 X-RAY DIFFRACTION 0.230 0.195 False True IGHV5 IGKV4 Kappa None None None None None 8fg0 C D 0 P peptide NA circumsporozoite protein IMMUNE SYSTEM 05/10/23 Crystal structure of the 3764 Fab in complex with the C-terminal PfCSP linker, PfCSP281-294. Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Burn Aschner, C., Julien, J.P. 2.36 X-RAY DIFFRACTION 0.237 0.176 False True IGHV3 IGKV2 Kappa None None None None None 8fg0 A B 0 Q peptide NA circumsporozoite protein IMMUNE SYSTEM 05/10/23 Crystal structure of the 3764 Fab in complex with the C-terminal PfCSP linker, PfCSP281-294. Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Burn Aschner, C., Julien, J.P. 2.36 X-RAY DIFFRACTION 0.237 0.176 False True IGHV3 IGKV2 Kappa None None None None None 8g2y N NA 0 A | B protein | protein NA | NA minig alpha s/q chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 05/10/23 Cryo-EM structure of ADGRF1 coupled to miniGs/q Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Jones, D., Rawson, S., Blacklow, S. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8guq S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 05/10/23 Cryo-EM structure of CB2-G protein complex Homo sapiens homo sapiens homo sapiens | homo sapiens Wu, L.J., Hua, T., Liu, Z.J., Li, X.T., Chang, H. 3.08 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gur S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 05/10/23 Cryo-EM structure of CP-CB2-G protein complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Wu, L.J., Hua, T., Liu, Z.J., Li, X.T., Chang, H. 2.84 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gus S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 05/10/23 Cryo-EM structure of HU-CB2-G protein complex Homo sapiens homo sapiens homo sapiens | homo sapiens Wu, L.J., Hua, T., Liu, Z.J., Li, X.T., Chang, H. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gut S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 05/10/23 Cryo-EM structure of LEI-CB2-Gi complex Homo sapiens; Homo sapiens neanderthalensis homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Li, X.T., Chang, H., Wu, L.J. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hk2 H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/10/23 C3aR-Gi-C3a protein complex Bos taurus; Homo sapiens; Rattus norvegicus rattus norvegicus homo sapiens | rattus norvegicus Wang, Y., Liu, W., Xu, Y., Zhuang, Y., Xu, H.E. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hk3 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/10/23 C3aR-Gi-apo protein complex Bos taurus; Homo sapiens; Rattus norvegicus rattus norvegicus homo sapiens | rattus norvegicus Wang, Y., Liu, W., Xu, Y., Zhuang, Y., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7uoj H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Nguyen, D.N., Tolbert, W.D., Pazgier, M. 4.02 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7uoj h l 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Nguyen, D.N., Tolbert, W.D., Pazgier, M. 4.02 ELECTRON MICROSCOPY NA NA False False IGHV4 unknown unknown None None None None None 7uoj D E 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Nguyen, D.N., Tolbert, W.D., Pazgier, M. 4.02 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7uoj d e 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Nguyen, D.N., Tolbert, W.D., Pazgier, M. 4.02 ELECTRON MICROSCOPY NA NA False False IGHV4 unknown unknown None None None None None 7uoj K M 0 I protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Nguyen, D.N., Tolbert, W.D., Pazgier, M. 4.02 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7uoj k m 0 I protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Nguyen, D.N., Tolbert, W.D., Pazgier, M. 4.02 ELECTRON MICROSCOPY NA NA False False IGHV4 unknown unknown None None None None None 7xjj S s 0 A | B protein | protein NA | NA g protein subunit alpha o1,guanine nucleotide-bindingprotein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 05/03/23 Cryo-EM structure of the galanin-bound GALR1-miniGo complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Jiang, W., Zheng, S. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8a94 R O 0 A protein NA sars-cov2 spike in 2-up conformation in complex with fab47 VIRAL PROTEIN 05/03/23 SARS CoV2 Spike in the 2-up state in complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Hallberg, B.M., Das, H. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8a94 T Q 0 C protein NA sars-cov2 spike in 2-up conformation in complex with fab47 VIRAL PROTEIN 05/03/23 SARS CoV2 Spike in the 2-up state in complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Hallberg, B.M., Das, H. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8a94 K E 0 B protein NA sars-cov2 spike in 2-up conformation in complex with fab47 VIRAL PROTEIN 05/03/23 SARS CoV2 Spike in the 2-up state in complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Hallberg, B.M., Das, H. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8a96 K J 0 C protein NA spike protein s1 VIRAL PROTEIN 05/03/23 SARS Cov2 Spike RBD in complex with Fab47 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Hallberg, B.M., Das, H. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8bb7 D NA 0 B protein NA plexin-b1 SIGNALING PROTEIN 05/03/23 Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 Camelidae; Mus musculus camelidae mus musculus Cowan, R., Hall, G., Carr, M. 2.95 X-RAY DIFFRACTION 0.229 0.203 False True IGHV1 NA NA None None None None None 8bb7 C NA 0 A protein NA plexin-b1 SIGNALING PROTEIN 05/03/23 Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 Camelidae; Mus musculus camelidae mus musculus Cowan, R., Hall, G., Carr, M. 2.95 X-RAY DIFFRACTION 0.229 0.203 False True IGHV1 NA NA None None None None None 8bf4 D NA 0 F protein NA plexin-b1 SIGNALING PROTEIN 05/03/23 Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14 Camelidae; Mus musculus camelidae mus musculus Cowan, R., Hall, G., Carr, M. 2.15 X-RAY DIFFRACTION 0.228 0.211 False True IGHV1 NA NA None None None None None 8bf4 E NA 0 F protein NA plexin-b1 SIGNALING PROTEIN 05/03/23 Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14 Camelidae; Mus musculus camelidae mus musculus Cowan, R., Hall, G., Carr, M. 2.15 X-RAY DIFFRACTION 0.228 0.211 False True IGHV1 NA NA None None None None None 8bf4 A NA 0 C protein NA plexin-b1 SIGNALING PROTEIN 05/03/23 Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14 Camelidae; Mus musculus camelidae mus musculus Cowan, R., Hall, G., Carr, M. 2.15 X-RAY DIFFRACTION 0.228 0.211 False True IGHV1 NA NA None None None None None 8bf4 B NA 0 C protein NA plexin-b1 SIGNALING PROTEIN 05/03/23 Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14 Camelidae; Mus musculus camelidae mus musculus Cowan, R., Hall, G., Carr, M. 2.15 X-RAY DIFFRACTION 0.228 0.211 False True IGHV1 NA NA None None None None None 8dy0 A a 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv GLK1 HL Homo sapiens homo sapiens Luo, J., Boucher, L.E. 2.1 X-RAY DIFFRACTION 0.224 0.182 True True unknown unknown unknown None None None None None 8dy0 B b 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv GLK1 HL Homo sapiens homo sapiens Luo, J., Boucher, L.E. 2.1 X-RAY DIFFRACTION 0.224 0.182 True True unknown unknown unknown None None None None None 8dy1 C c 0 A protein NA interleukin-17a IMMUNE SYSTEM 05/03/23 Crystal Structure of scFv CAT2200 LH in complex with IL-17A Homo sapiens homo sapiens homo sapiens Luo, J., Armstrong, A.A. 2.68 X-RAY DIFFRACTION 0.268 0.221 True True unknown unknown unknown None None None None None 8dy1 D d 0 B protein NA interleukin-17a IMMUNE SYSTEM 05/03/23 Crystal Structure of scFv CAT2200 LH in complex with IL-17A Homo sapiens homo sapiens homo sapiens Luo, J., Armstrong, A.A. 2.68 X-RAY DIFFRACTION 0.268 0.221 True True unknown unknown unknown None None None None None 8dy2 A a 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv GLK1 Homo sapiens homo sapiens Luo, J., Boucher, L.E. 1.65 X-RAY DIFFRACTION 0.246 0.215 True True unknown unknown unknown None None None None None 8dy2 B b 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv GLK1 Homo sapiens homo sapiens Luo, J., Boucher, L.E. 1.65 X-RAY DIFFRACTION 0.246 0.215 True True unknown unknown unknown None None None None None 8dy2 C c 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv GLK1 Homo sapiens homo sapiens Luo, J., Boucher, L.E. 1.65 X-RAY DIFFRACTION 0.246 0.215 True True unknown unknown unknown None None None None None 8dy2 D d 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv GLK1 Homo sapiens homo sapiens Luo, J., Boucher, L.E. 1.65 X-RAY DIFFRACTION 0.246 0.215 True True unknown unknown unknown None None None None None 8dy3 A a 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv GLK2 HL Homo sapiens homo sapiens Luo, J., Boucher, L.E. 1.509 X-RAY DIFFRACTION 0.209 0.183 True True unknown unknown unknown None None None None None 8dy4 A a 0 NA NA NA NA IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv CAT2200 HL Homo sapiens homo sapiens Luo, J., Boucher, L.E. 2.4 X-RAY DIFFRACTION 0.328 0.262 True True unknown unknown unknown None None None None None 8dy5 A a 0 C protein NA interleukin-17a IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv CAT2200 LH in complex with IL-17A Homo sapiens homo sapiens homo sapiens Luo, J., Boucher, L.E. 2.2 X-RAY DIFFRACTION 0.232 0.188 True True unknown unknown unknown None None None None None 8dy5 B b 0 D protein NA interleukin-17a IMMUNE SYSTEM 05/03/23 Crystal Structure of spFv CAT2200 LH in complex with IL-17A Homo sapiens homo sapiens homo sapiens Luo, J., Boucher, L.E. 2.2 X-RAY DIFFRACTION 0.232 0.188 True True unknown unknown unknown None None None None None 8dzp E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/03/23 Structure of KOR and G protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Fay, J.F., Che, T. 2.71 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dzq E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/03/23 momSalB bound Kappa Opioid Receptor in complex with GoA Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Fay, J.F., Che, T. 2.82 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dzr E e 0 B | C protein | protein NA | NA g alpha gustducin protein | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/03/23 GR89,696 bound Kappa Opioid Receptor in complex with Ggustducin Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Fay, J.F., Che, T. 2.61 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dzs E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(z) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/03/23 GR89,696 bound Kappa Opioid Receptor in complex with Gz Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Fay, J.F., Che, T. 2.65 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8f0g X Y 0 C | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 Structure of SARS-CoV-2 Omicron BA.1 spike in complex with antibody Fab 1C3 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Yu, X., Zyla, D., Hastie, K.M., Saphire, E.O. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f0h B D 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 Structure of SARS-CoV-2 spike with antibody Fabs 2A10 and 1H2 (Local refinement of the RBD and Fabs 1H2 and 2A10) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yu, X., Zyla, D., Hastie, K.M., Saphire, E.O. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8f0h H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 Structure of SARS-CoV-2 spike with antibody Fabs 2A10 and 1H2 (Local refinement of the RBD and Fabs 1H2 and 2A10) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yu, X., Zyla, D., Hastie, K.M., Saphire, E.O. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8fax A B 0 L peptide NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/03/23 Fab 1249A8-MERS Stem Helix Complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Deshpande, A., Schormann, N., Piepenbrink, M.S., Martinez-Sobrido, L., Kobie, J.J., Walter, M.R. 2.1 X-RAY DIFFRACTION 0.240 0.182 False True IGHV1 IGKV3 Kappa None None None None None 8gs9 H K 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/03/23 SARS-CoV-2 BA.2 spike RBD in complex bound with VacBB-551 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, C.C., Ju, B., Shen, S.L., Zhang, Z. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7uja B D 0 A protein NA rsv variant (construct pxcs847a) f1 VIRAL PROTEIN 04/19/23 Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A) Mus musculus; Respiratory syncytial virus mus musculus mus musculus respiratory syncytial virus Lees, J.A., Ammirati, M., Han, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7uja E F 0 A | P protein | protein NA | NA rsv variant (construct pxcs847a) f1 | rsv variant (construct pxcs847a) f2 VIRAL PROTEIN 04/19/23 Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A) Mus musculus; Respiratory syncytial virus mus musculus mus musculus respiratory syncytial virus | respiratory syncytial virus Lees, J.A., Ammirati, M., Han, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uja G H 0 K protein NA rsv variant (construct pxcs847a) f1 VIRAL PROTEIN 04/19/23 Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A) Mus musculus; Respiratory syncytial virus mus musculus mus musculus respiratory syncytial virus Lees, J.A., Ammirati, M., Han, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7uja I J 0 K | R protein | protein NA | NA rsv variant (construct pxcs847a) f1 | rsv variant (construct pxcs847a) f2 VIRAL PROTEIN 04/19/23 Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A) Mus musculus; Respiratory syncytial virus mus musculus mus musculus respiratory syncytial virus | respiratory syncytial virus Lees, J.A., Ammirati, M., Han, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uja L M 0 C protein NA rsv variant (construct pxcs847a) f1 VIRAL PROTEIN 04/19/23 Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A) Mus musculus; Respiratory syncytial virus mus musculus mus musculus respiratory syncytial virus Lees, J.A., Ammirati, M., Han, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7uja N O 0 C | Q protein | protein NA | NA rsv variant (construct pxcs847a) f1 | rsv variant (construct pxcs847a) f2 VIRAL PROTEIN 04/19/23 Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A) Mus musculus; Respiratory syncytial virus mus musculus mus musculus respiratory syncytial virus | respiratory syncytial virus Lees, J.A., Ammirati, M., Han, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8euq C D 0 A | B protein | protein NA | NA hla class ii histocompatibility antigen, dr alpha chain | hemagglutinin ha1 chain,hla class ii histocompatibilityantigen dr beta chain IMMUNE SYSTEM 04/19/23 Crystal structure of HLA-DRA*01:01/HLA-DRB1*04:01 in complex with c44H10 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens homo sapiens | influenza a virus, homo sapiens Kassardjian, A., Julien, J.-P. 3.09 X-RAY DIFFRACTION 0.244 0.200 False True IGHV2 IGKV9 Kappa None None None None None 8euq I H 0 F | G protein | protein NA | NA hla class ii histocompatibility antigen, dr alpha chain | hemagglutinin ha1 chain,hla class ii histocompatibilityantigen dr beta chain IMMUNE SYSTEM 04/19/23 Crystal structure of HLA-DRA*01:01/HLA-DRB1*04:01 in complex with c44H10 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens homo sapiens | influenza a virus, homo sapiens Kassardjian, A., Julien, J.-P. 3.09 X-RAY DIFFRACTION 0.244 0.200 False True IGHV2 IGKV9 Kappa None None None None None 8fr6 D E 0 A | C protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8fr6 H L 0 B | G protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8fr6 J K 0 F | I protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, S., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8g85 H L 0 K | J protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN 04/19/23 vFP52.02 Fab in complex with BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 8g85 A C 0 E | D protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN 04/19/23 vFP52.02 Fab in complex with BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 8g85 F I 0 B | G protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN 04/19/23 vFP52.02 Fab in complex with BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 8gas H L 0 B | G protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8gas C A 0 E | D protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8gas I F 0 K | J protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7ur6 H L 0 B | G protein | protein NA | NA gp41 | gp120 VIRAL PROTEIN/Immune System 04/26/23 Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7ur6 D E 0 C | A protein | protein NA | NA gp41 | gp120 VIRAL PROTEIN/Immune System 04/26/23 Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7ur6 J K 0 I | F protein | protein NA | NA gp41 | gp120 VIRAL PROTEIN/Immune System 04/26/23 Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664 Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7url A a 0 NA NA NA NA PEPTIDE BINDING PROTEIN 04/26/23 The crystal structure of anti-HIV_scFv Mus musculus mus musculus Chen, S.H., Snow, C.D. 1.49 X-RAY DIFFRACTION 0.223 0.192 True True unknown unknown unknown None None None None None 7url B b 0 NA NA NA NA PEPTIDE BINDING PROTEIN 04/26/23 The crystal structure of anti-HIV_scFv Mus musculus mus musculus Chen, S.H., Snow, C.D. 1.49 X-RAY DIFFRACTION 0.223 0.192 True True unknown unknown unknown None None None None None 7xik H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2-Omicron-RBD and B38-GWP/P-VK antibody complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J. 2.89 X-RAY DIFFRACTION 0.263 0.211 False True IGHV3 IGKV1 Kappa None None None None None 7xil H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2-Beta-RBD and B38-GWP/P-VK antibody complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J. 2.91 X-RAY DIFFRACTION 0.256 0.206 False True IGHV3 IGKV1 Kappa None None None None None 7xk9 B NA 0 A protein NA endolysin,beta-2 adrenergic receptor MEMBRANE PROTEIN 04/26/23 Structure of human beta2 adrenergic receptor bound to constrained isoproterenol Enterobacteria phage T4; Homo sapiens homo sapiens enterobacteria phage t4, homo sapiens Xu, X., Shonberg, J., Kaindl, J., Clark, M., Stobel, A., Maul, L., Mayer, D., Hubner, H., Venkatakrishnan, A., Dror, R., Kobilka, B.K., Sunahara, R., Liu, X., Gmeiner, P. 3.4 X-RAY DIFFRACTION 0.261 0.223 False True IGHV1 NA NA None None None None None 7xka B NA 0 A protein NA endolysin,beta-2 adrenergic receptor MEMBRANE PROTEIN 04/26/23 Structure of human beta2 adrenergic receptor bound to constrained epinephrine Enterobacteria phage T4; Homo sapiens homo sapiens enterobacteria phage t4, homo sapiens Xu, X., Shonberg, J., Kaindl, J., Clark, M., Stobel, A., Maul, L., Mayer, D., Hubner, H., Venkatakrishnan, A., Dror, R., Kobilka, B.K., Sunahara, R., Liu, X., Gmeiner, P. 3.1 X-RAY DIFFRACTION 0.272 0.226 False True IGHV1 NA NA None None None None None 7xs8 A L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-1H1 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.8 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8flq N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/26/23 Human PTH1R in complex with PTH(1-34) and Gs Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cary, B.P., Belousoff, M.J., Piper, S.J., Wootten, D., Sexton, P.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8flr N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/26/23 Human PTH1R in complex with PTHrP and Gs Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cary, B.P., Belousoff, M.J., Piper, S.J., Wootten, D., Sexton, P.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8fls N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/26/23 Human PTH1R in complex with Abaloparatide and Gs Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cary, B.P., Belousoff, M.J., Piper, S.J., Wootten, D., Sexton, P.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8flt N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/26/23 Human PTH1R in complex with M-PTH(1-14) and Gs Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cary, B.P., Belousoff, M.J., Piper, S.J., Wootten, D., Sexton, P.M. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8flu N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/26/23 Human PTH1R in complex with LA-PTH and Gs Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cary, B.P., Belousoff, M.J., Piper, S.J., Wootten, D., Sexton, P.M. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8heb E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 1 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8heb G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 1 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8heb I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 1 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8hec E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 2 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8hec G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 2 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8hec I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 2 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8hed G F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/26/23 Local refinement of the SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8sbb B NA 0 A protein NA alkane 1-monooxygenase MEMBRANE PROTEIN 04/26/23 Cryo-EM structure of FtAlkB Fontimonas thermophila; synthetic construct synthetic construct fontimonas thermophila Zhang, J., Feng, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7umn H L 0 A protein NA hemagglutinin VIRAL PROTEIN 04/19/23 H1 Solomon Islands 2006 hemagglutinin in complex with Ab36 Influenza A virus (A/Solomon Islands/3/2006(H1N1)); Mus musculus mus musculus mus musculus influenza a virus (a/solomonislands/3/2006(h1n1)) Windsor, I.W., Caradonna, T.M., Schmidt, A.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7umn I M 0 B protein NA hemagglutinin VIRAL PROTEIN 04/19/23 H1 Solomon Islands 2006 hemagglutinin in complex with Ab36 Influenza A virus (A/Solomon Islands/3/2006(H1N1)); Mus musculus mus musculus mus musculus influenza a virus (a/solomonislands/3/2006(h1n1)) Windsor, I.W., Caradonna, T.M., Schmidt, A.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7umn J N 0 C protein NA hemagglutinin VIRAL PROTEIN 04/19/23 H1 Solomon Islands 2006 hemagglutinin in complex with Ab36 Influenza A virus (A/Solomon Islands/3/2006(H1N1)); Mus musculus mus musculus mus musculus influenza a virus (a/solomonislands/3/2006(h1n1)) Windsor, I.W., Caradonna, T.M., Schmidt, A.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7uow H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/19/23 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 034_32 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7uow J I 0 C protein NA spike glycoprotein VIRAL PROTEIN 04/19/23 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 034_32 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7wn2 H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain (RBD) in complex with NCV2SG53 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 2.35 X-RAY DIFFRACTION 0.279 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7wn2 B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain (RBD) in complex with NCV2SG53 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 2.35 X-RAY DIFFRACTION 0.279 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7wnb H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain (RBD) in complex with NCV2SG48 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 2.18 X-RAY DIFFRACTION 0.281 0.245 False True IGHV3 IGKV1 Kappa None None None None None 7xj6 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab in the class 1 conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xj6 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab in the class 1 conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xj6 K J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab in the class 1 conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7xj6 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab in the class 1 conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xj8 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab in the class 2 conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xj8 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab in the class 2 conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xj8 K J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab in the class 2 conformation Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7xj9 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Local refinement of the SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xj9 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Local refinement of the SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xj9 K J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Local refinement of the SARS-CoV-2 BA.1 Spike trimer in complex with 55A8 Fab and 58G6 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yac S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/19/23 Paltusotine-bound SSTR2-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, J., Shao, Z. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yae S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/19/23 Octreotide-bound SSTR2-Gi complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Zhao, J., Shao, Z. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ykd S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PEPTIDE BINDING PROTEIN 04/19/23 Cryo-EM structure of the human chemerin receptor 1 complex with the C-terminal nonapeptide of chemerin Homo sapiens; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Chen, G., Liao, Q., Ye, R.D., Wang, J. 2.81 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yow H L 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 04/19/23 Crystal structure of SARS-CoV-2 omicron variant spike receptor-binding domain (RBD) in complex with NCV2SG48 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 3.3 X-RAY DIFFRACTION 0.254 0.209 False True IGHV3 IGKV1 Kappa None None None None None 7yow B A 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 04/19/23 Crystal structure of SARS-CoV-2 omicron variant spike receptor-binding domain (RBD) in complex with NCV2SG48 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 3.3 X-RAY DIFFRACTION 0.254 0.209 False True IGHV3 IGKV1 Kappa None None None None None 7zjl j i 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/19/23 Delta SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pichkur, E.B., Lyukmanova, E.N., Shenkarev, Z.O. 2.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 7zjl h g 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/19/23 Delta SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pichkur, E.B., Lyukmanova, E.N., Shenkarev, Z.O. 2.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 7zjl l k 0 C protein NA spike glycoprotein VIRAL PROTEIN 04/19/23 Delta SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pichkur, E.B., Lyukmanova, E.N., Shenkarev, Z.O. 2.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGLV2 Lambda None None None None None 8ct6 H L 0 A protein NA cobra p1 ha Viral Protein/IMMUNE SYSTEM 04/19/23 1F8 mAb in complex with the computationally optimized broadly reactive H1 influenza hemagglutinin P1 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Dzimianski, J.V., DuBois, R.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ct6 J K 0 C protein NA cobra p1 ha Viral Protein/IMMUNE SYSTEM 04/19/23 1F8 mAb in complex with the computationally optimized broadly reactive H1 influenza hemagglutinin P1 Influenza A virus; Mus musculus mus musculus mus musculus influenza a virus Dzimianski, J.V., DuBois, R.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dp3 H L 0 R nucleic-acid NA rna (90-mer) IMMUNE SYSTEM/RNA 04/19/23 Crystal structure of coxsackievirus B3 cloverleaf RNA replication element synthetic construct; SYNTHETIC CONSTRUCT synthetic construct synthetic construct coxsackievirus b3 Das, N.K., Koirala, D. 1.91 X-RAY DIFFRACTION 0.259 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8dto G H 0 E protein NA ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer Human immunodeficiency virus; Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Stalls, V., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8dto C D 0 A protein NA ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer Human immunodeficiency virus; Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Stalls, V., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8dto K L 0 I protein NA ch848.3.d0949.10.17chim.6r.ds.sosip.664_n133d_n138t gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Vaccine elicited Antibody MU89 bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer Human immunodeficiency virus; Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Stalls, V., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8dy6 C D 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Vaccine elicited Antibody MU89+S27Y bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Stalls, V., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8dy6 G H 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Vaccine elicited Antibody MU89+S27Y bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Stalls, V., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8dy6 K L 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Vaccine elicited Antibody MU89+S27Y bound to CH848.D949.10.17_N133D_N138T.DS.SOSIP.664 HIV-1 Env trimer Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Stalls, V., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8g94 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 04/19/23 Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Chen, H., Li, X. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8g9w H L 0 O | E protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 IMMUNE SYSTEM 04/19/23 Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1) Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Changela, A., Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 8g9x H L 0 O | B protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp41 IMMUNE SYSTEM 04/19/23 Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2) Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Changela, A., Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 8g9y H L 0 D | O | E protein | protein | protein NA | NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp41 | envelope glycoprotein gp120 IMMUNE SYSTEM 04/19/23 Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 3) Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Changela, A., Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 8i5h H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Crystal structure of SARS-CoV-2 delta variant spike receptor-binding domain (RBD) in complex with NCV2SG48 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 2.38 X-RAY DIFFRACTION 0.230 0.188 False True IGHV3 IGKV1 Kappa None None None None None 8i5h B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Crystal structure of SARS-CoV-2 delta variant spike receptor-binding domain (RBD) in complex with NCV2SG48 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 2.38 X-RAY DIFFRACTION 0.230 0.188 False True IGHV3 IGKV1 Kappa None None None None None 8i5h E F 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Crystal structure of SARS-CoV-2 delta variant spike receptor-binding domain (RBD) in complex with NCV2SG48 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 2.38 X-RAY DIFFRACTION 0.230 0.188 False True IGHV3 IGKV1 Kappa None None None None None 8i5i H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 Crystal structure of SARS-CoV-2 delta variant spike receptor-binding domain (RBD) in complex with NCV2SG53 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yamamoto, A., Higashiura, A. 3.06 X-RAY DIFFRACTION 0.373 0.228 False True IGHV3 IGKV1 Kappa None None None None None 8san C D 0 A protein NA ch848.0836.10 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of VRC01-CH848.0836.10 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 4.6 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 8san G H 0 E protein NA ch848.0836.10 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of VRC01-CH848.0836.10 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 4.6 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 8san K L 0 I protein NA ch848.0836.10 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of VRC01-CH848.0836.10 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 4.6 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 8saq C D 0 A protein NA ch848.0526.25 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.6-CH848.0526.25 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8saq H I 0 E protein NA ch848.0526.25 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.6-CH848.0526.25 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8saq M N 0 K protein NA ch848.0526.25 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.6-CH848.0526.25 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sar C D 0 A protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sar H I 0 F protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sar M N 0 K protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sas C D 0 A protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.5-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sas H I 0 F protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.5-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sas M N 0 K protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.5-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sau C D 0 A protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.4-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sau H I 0 F protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.4-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sau M N 0 K protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.4-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sav C D 0 A protein NA ch848.0526.25 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of VRC01-CH848.0526.25 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8sav G H 0 E protein NA ch848.0526.25 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of VRC01-CH848.0526.25 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8sav K L 0 I protein NA ch848.0526.25 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of VRC01-CH848.0526.25 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 8saw C D 0 A protein NA ch848.3.d0949.10.17chim.6r.sosip.664 gp120a VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.UCA.G57R-CH848.10.17DT HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8saw H I 0 E protein NA ch848.3.d0949.10.17chim.6r.sosip.664 gp120a VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.UCA.G57R-CH848.10.17DT HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8saw M N 0 K protein NA ch848.3.d0949.10.17chim.6r.sosip.664 gp120a VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.UCA.G57R-CH848.10.17DT HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sax C D 0 A protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.UCA-CH848.10.17DT HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sax G H 0 E protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.UCA-CH848.10.17DT HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sax K L 0 I protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.UCA-CH848.10.17DT HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8say C D 0 A protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.3-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8say H I 0 F protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.3-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8say M N 0 K protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.3-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8saz C D 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.I5.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8saz H I 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.I5.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8saz M N 0 K protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.I5.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb0 C D 0 A protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I4.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb0 H I 0 F protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I4.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb0 M N 0 K protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I4.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb1 C D 0 A protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I3-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb1 H I 0 F protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I3-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb1 M N 0 K protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I3-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb2 C D 0 A protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I2-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb2 H I 0 F protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I2-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb2 M N 0 K protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I2-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb3 C D 0 A protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.2-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb3 H I 0 F protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.2-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb3 M N 0 K protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.2-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb4 C D 0 A protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.1-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb4 H I 0 F protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.1-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb4 M N 0 K protein NA ch848.10.17 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 CryoEM structure of DH270.1-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb5 C D 0 A protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I1.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb5 H I 0 F protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I1.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8sb5 M N 0 K protein NA ch848.10.17.sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/19/23 CryoEM structure of DH270.I1.6-CH848.10.17 HIV-1 06TG.HT008; Homo sapiens homo sapiens homo sapiens hiv-1 06tg.ht008 Henderson, R., Zhou, Y., Stalls, V., Bartesaghi, B., Acharya, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 8d21 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral Protein 04/12/23 Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8d21 E F 0 C | D protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral Protein 04/12/23 Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8d21 J K 0 G | I protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral Protein 04/12/23 Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dmh F E 0 a | A protein | protein NA | NA unknown | glycoprotein g2,cobalamin adenosyltransferase-like domain-containing protein trimerization tag VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28 Homo sapiens; Lymphocytic choriomeningitis virus homo sapiens homo sapiens lymphocytic choriomeningitis virus | lymphocytic choriomeningitis virus Moon-Walker, A., Hastie, K.M., Zyla, D.S., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dmh H G 0 b | B protein | protein NA | NA unknown | glycoprotein g2,cobalamin adenosyltransferase-like domain-containing protein trimerization tag VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28 Homo sapiens; Lymphocytic choriomeningitis virus homo sapiens homo sapiens lymphocytic choriomeningitis virus | lymphocytic choriomeningitis virus Moon-Walker, A., Hastie, K.M., Zyla, D.S., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8dmh J I 0 c | C protein | protein NA | NA unknown | glycoprotein g2,cobalamin adenosyltransferase-like domain-containing protein trimerization tag VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28 Homo sapiens; Lymphocytic choriomeningitis virus homo sapiens homo sapiens lymphocytic choriomeningitis virus | lymphocytic choriomeningitis virus Moon-Walker, A., Hastie, K.M., Zyla, D.S., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7txw H L 0 A protein NA ookinete surface protein p25 IMMUNE SYSTEM 04/12/23 Crystal structure of the complex of the malaria sexual stage protein and vaccine target Pfs25 with the Fab fragment of a transmission blocking antibody 1G2 Mus musculus; Plasmodium falciparum 3D7 mus musculus mus musculus plasmodium falciparum 3d7 Singh, K., Gittis, A.G., Garboczi, D.N. 2.17 X-RAY DIFFRACTION 0.230 0.177 False True IGHV1 IGKV1 Kappa None None None None None 7ufn B C 0 F peptide NA pfcsp peptide 21 IMMUNE SYSTEM 04/12/23 Structure of PfCSP peptide 21 with antibody P3-21 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Tripathi, P., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.204 0.164 False True IGHV1 IGKV4 Kappa None None None None None 7ufn A D 0 E peptide NA pfcsp peptide 21 IMMUNE SYSTEM 04/12/23 Structure of PfCSP peptide 21 with antibody P3-21 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Tripathi, P., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.204 0.164 False True IGHV1 IGKV4 Kappa None None None None None 7ufo H L 0 A peptide NA pfcsp peptide 21 IMMUNE SYSTEM 04/12/23 Structure of PfCSP peptide 21 with antibody P3-42 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Tripathi, P., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 IGKV4 Kappa None None None None None 7ufq H L 0 A peptide NA pfcsp peptide 21 IMMUNE SYSTEM 04/12/23 Structure of PfCSP peptide 21 with antibody P3-43 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.285 0.215 False True IGHV1 IGKV4 Kappa None None None None None 7ufq B D 0 C peptide NA pfcsp peptide 21 IMMUNE SYSTEM 04/12/23 Structure of PfCSP peptide 21 with antibody P3-43 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.285 0.215 False True IGHV1 IGKV4 Kappa None None None None None 7yit D NA 0 A protein NA kappa-type opioid receptor MEMBRANE PROTEIN/INHIBITOR/IMMUNE SYSTEM 04/12/23 Molecular mechanism of biased signaling at the kappa opioid receptor Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens Kim, K., Che, T. 3.3 X-RAY DIFFRACTION 0.335 0.285 False True IGHV1 NA NA None None None None None 8fu6 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/12/23 GCGR-Gs complex in the presence of RAMP2 Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Krishna Kumar, K., O'Brien, E.S., Wang, H., Montabana, E., Kobilka, B.K. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8gzz E D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 Local refinement of SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8gzz G F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 Local refinement of SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8h00 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in the class 1 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8h00 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in the class 1 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8h00 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in the class 1 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8h01 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in class 2 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8h01 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in class 2 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8h01 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in class 2 conformation Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8ibu E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/12/23 Cryo-EM structure of the erythromycin-bound motilin receptor-Gq protein complex Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens You, C., Jiang, Y., Xu, H.E., Xu, Y. 3.51 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ibv E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/12/23 Cryo-EM structure of the motilin-bound motilin receptor-Gq protein complex Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Jiang, Y., Xu, H.E., You, C., Xu, Y. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8itu E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 IgG. Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8itu G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 IgG. Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8itu I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/23 SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 IgG. Oryctolagus cuniculus; Severe acute respiratory syndrome coronavirus 2 oryctolagus cuniculus oryctolagus cuniculus severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 8ont B NA 0 A protein NA nramp related aluminium transporter TRANSPORT PROTEIN 04/12/23 Structure of Setaria italica NRAT in complex with a nanobody Lama glama; Setaria italica lama glama setaria italica Ramanadane, K., Liziczai, M., Markovic, D., Straub, M.S., Rosalen, G.T., Udovcic, A., Dutzler, R., Manatschal, C. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dcm A B 0 C protein NA adp-ribosylating binary toxin binding subunit cdtb TOXIN/IMMUNE SYSTEM 01/08/09 Crystal structure of Clostridioides difficile binary toxin proCDTb lacking D4 in complex with BINTOXB/22 Fab Clostridioides difficile; Mus musculus mus musculus mus musculus clostridioides difficile Goldsmith, J.A., McLellan, J.S. 2.5 X-RAY DIFFRACTION 0.227 0.198 False True IGHV9 IGKV6 Kappa None None None None None 7uia B NA 0 A protein NA neurotoxin type e TOXIN 04/05/23 Crystal structure of BoNT/E receptor binding domain in complex with SV2 and VHH Clostridium botulinum; Homo sapiens; Vicugna pacos vicugna pacos clostridium botulinum Zheng, L., Rongsheng, J., Peng, C. 2.59 X-RAY DIFFRACTION 0.249 0.226 False True IGHV1 NA NA None None None None None 7uia E NA 0 D protein NA neurotoxin type e TOXIN 04/05/23 Crystal structure of BoNT/E receptor binding domain in complex with SV2 and VHH Clostridium botulinum; Homo sapiens; Vicugna pacos vicugna pacos clostridium botulinum Zheng, L., Rongsheng, J., Peng, C. 2.59 X-RAY DIFFRACTION 0.249 0.226 False True IGHV1 NA NA None None None None None 4edw H L 0 V protein NA beta-nerve growth factor IMMUNE SYSTEM 04/02/14 Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab) Homo sapiens homo sapiens homo sapiens homo sapiens Eigenbrot, C., Ultsch, M. 2.48 X-RAY DIFFRACTION 0.249 0.200 False True IGHV4 IGKV1 Kappa None None None None None 7upa H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 01/08/09 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H8 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 7upa B E 0 G protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 01/08/09 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H8 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 7upa C F 0 D protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 01/08/09 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H8 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 7uop H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 4H3 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV4 Kappa None None None None None 7uop B E 0 G protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 4H3 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV4 Kappa None None None None None 7uop C F 0 D protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 4H3 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV4 Kappa None None None None None 7up9 H L 0 G | A protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 2D3 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus | nipah henipavirus Byrne, P.O., McLellan, J.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 7upb B E 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H1 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7upb C F 0 D protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H1 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7upb H L 0 G protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H1 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7upd B E 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 2B12 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV8 Kappa None None None None None 7upd C F 0 G protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 2B12 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV8 Kappa None None None None None 7upd H L 0 D protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 2B12 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV8 Kappa None None None None None 7upk H L 0 D protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1A9 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 7upk C F 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1A9 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 7upk E G 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 03/29/23 Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1A9 Mus musculus; Nipah henipavirus mus musculus mus musculus nipah henipavirus Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 7ys6 E e 0 B | C protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/29/23 Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhao, Q.Y., Wang, Y.F., He, L., Wang, S., Cong, Y. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8cxr E NA 0 A protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/Transferase 03/29/23 Crystal structure of MraY bound to a sphaerimicin analogue Aquifex aeolicus; Lama glama lama glama aquifex aeolicus Mashalidis, E.H., Lee, S.Y. 3.65 X-RAY DIFFRACTION 0.295 0.249 False True IGHV1 NA NA None None None None None 8cxr G NA 0 C protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/Transferase 03/29/23 Crystal structure of MraY bound to a sphaerimicin analogue Aquifex aeolicus; Lama glama lama glama aquifex aeolicus Mashalidis, E.H., Lee, S.Y. 3.65 X-RAY DIFFRACTION 0.295 0.249 False True IGHV1 NA NA None None None None None 8cxr F NA 0 B protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/Transferase 03/29/23 Crystal structure of MraY bound to a sphaerimicin analogue Aquifex aeolicus; Lama glama lama glama aquifex aeolicus Mashalidis, E.H., Lee, S.Y. 3.65 X-RAY DIFFRACTION 0.295 0.249 False True IGHV1 NA NA None None None None None 8cxr H NA 0 D protein NA phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/Transferase 03/29/23 Crystal structure of MraY bound to a sphaerimicin analogue Aquifex aeolicus; Lama glama lama glama aquifex aeolicus Mashalidis, E.H., Lee, S.Y. 3.65 X-RAY DIFFRACTION 0.295 0.249 False True IGHV1 NA NA None None None None None 8d7e F G 0 C protein NA ciliary neurotrophic factor receptor subunit alpha CYTOKINE/Immune System 03/29/23 Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies Homo sapiens homo sapiens homo sapiens homo sapiens Zhou, Y., Franklin, M.C. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8d7e D E 0 C protein NA ciliary neurotrophic factor receptor subunit alpha CYTOKINE/Immune System 03/29/23 Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies Homo sapiens homo sapiens homo sapiens homo sapiens Zhou, Y., Franklin, M.C. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dk6 H L 0 E protein NA envelope glycoprotein e2 VIRAL PROTEIN 03/29/23 Structure of hepatitis C virus envelope N-terminal truncated glycoprotein 2 (E2) (residues 456-713) from J6 genotype Hepacivirus C; Mus musculus mus musculus mus musculus hepacivirus c Kumar, A., Rohe, T., Elrod, E.J., Khan, A.G., Dearborn, A.D., Kissinger, R., Grakoui, A., Marcotrigiano, J. 2.45 X-RAY DIFFRACTION 0.232 0.203 False True IGHV14 IGKV8 Kappa None None None None None 8f0l H L 0 P peptide NA t-cell surface glycoprotein cd3 epsilon chain IMMUNE SYSTEM 03/29/23 Crystal Structure of the Human T cell Receptor CD3(EPSILON) N-Terminal Peptide Complexed with ADI-26906 FAB Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Battles, M.B., Welin, M. 1.81 X-RAY DIFFRACTION 0.195 0.166 False True IGHV1 IGKV4 Kappa None None None None None 8f0l A B 0 Q peptide NA t-cell surface glycoprotein cd3 epsilon chain IMMUNE SYSTEM 03/29/23 Crystal Structure of the Human T cell Receptor CD3(EPSILON) N-Terminal Peptide Complexed with ADI-26906 FAB Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Battles, M.B., Welin, M. 1.81 X-RAY DIFFRACTION 0.195 0.166 False True IGHV1 IGKV4 Kappa None None None None None 8f8v A NA 0 NA NA NA NA IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 Camelidae mixed library camelidae mixed library Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Andi, B. 1.81 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 NA NA None None None None None 8f8v B NA 0 NA NA NA NA IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 Camelidae mixed library camelidae mixed library Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Andi, B. 1.81 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 NA NA None None None None None 8f8w C NA 0 B protein NA afucosylated igg1 fragment IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form I Camelidae mixed library; Homo sapiens camelidae mixed library homo sapiens Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Oren, D. 2.71 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 8f8w D NA 0 A protein NA afucosylated igg1 fragment IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form I Camelidae mixed library; Homo sapiens camelidae mixed library homo sapiens Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Oren, D. 2.71 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 8f8w G NA 0 F protein NA afucosylated igg1 fragment IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form I Camelidae mixed library; Homo sapiens camelidae mixed library homo sapiens Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Oren, D. 2.71 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 8f8w H NA 0 E protein NA afucosylated igg1 fragment IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form I Camelidae mixed library; Homo sapiens camelidae mixed library homo sapiens Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Oren, D. 2.71 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 8f8x C NA 0 B protein NA uncharacterized protein dkfzp686c11235 IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form II Camelidae mixed library; Homo sapiens camelidae mixed library homo sapiens Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Oren, D. 2.6 X-RAY DIFFRACTION 0.285 0.215 False True IGHV1 NA NA None None None None None 8f8x D NA 0 A protein NA uncharacterized protein dkfzp686c11235 IMMUNE SYSTEM 03/29/23 Crystal structure of Nb.X0 bound to the afucosylated human IgG1 fragment crystal form II Camelidae mixed library; Homo sapiens camelidae mixed library homo sapiens Goldgur, Y., Ravetch, J., Gupta, A., Kao, K., Oren, D. 2.6 X-RAY DIFFRACTION 0.285 0.215 False True IGHV1 NA NA None None None None None 8fmz E e 0 B | C protein | protein NA | NA minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/29/23 Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator Escherichia coli; Homo sapiens; Lama glama; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama escherichia coli | homo sapiens Krumm, B.E., Diberto, J.F., Olsen, R.H.J., Kang, H., Slocum, S.T., Zhang, S., Strachan, R.T., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8fn0 E e 0 B | C protein | protein NA | NA minigo | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/29/23 CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator Escherichia coli; Homo sapiens; Lama glama; Rattus norvegicus; SYNTHETIC CONSTRUCT lama glama escherichia coli | homo sapiens Krumm, B.E., DiBerto, J.F., Olsen, R.H.J., Kang, H., Slocum, S.T., Zhang, S., Strachan, R.T., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8fn1 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/29/23 CryoEM structure of Go-coupled NTSR1 Escherichia coli; Homo sapiens; Rattus norvegicus; Spodoptera frugiperda; SYNTHETIC CONSTRUCT spodoptera frugiperda, homo sapiens | homo sapiens Krumm, B.E., DiBerto, J.F., Olsen, R.H.J., Kang, H., Slocum, S.T., Zhang, S., Strachan, R.T., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8i2g N NA 0 A | G | B protein | protein | protein NA | NA | NA chimera of guanine nucleotide-binding protein g(s) subunitalpha and guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 HORMONE 03/29/23 FSHR-Follicle stimulating hormone-compound 716340-Gs complex Homo sapiens; Lama glama; Mus musculus domesticus lama glama mus musculus domesticus, homo sapiens | homo sapiens | homo sapiens Duan, J., Xu, P., Yang, J., Ji, Y., Zhang, H., Mao, C., Luan, X., Jiang, Y., Zhang, Y., Zhang, S., Xu, H.E. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8il3 B A 0 C protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 HYDROLASE 03/29/23 Cryo-EM structure of CD38 in complex with FTL004 Homo sapiens homo sapiens homo sapiens homo sapiens Yang, J., Wang, Y., Zhang, G. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV3 Kappa None None None None None 8en1 C NA 0 A protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 30 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 2.4 X-RAY DIFFRACTION 0.264 0.207 False True IGHV1 NA NA None None None None None 8en1 D NA 0 B protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 30 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 2.4 X-RAY DIFFRACTION 0.264 0.207 False True IGHV1 NA NA None None None None None 7yag C NA 0 A protein NA calcium-transporting atpase type 2c member 1 TRANSPORT PROTEIN 03/22/23 CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Chen, Z., Watanabe, S., Inaba, K. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7x93 E F 0 G | D protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 03/22/23 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab765 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7x94 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/22/23 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab712 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGLV3 Lambda None None None None None 7x95 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/22/23 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab709 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7x96 H L 0 G protein NA spike glycoprotein VIRAL PROTEIN 03/22/23 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab847 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7yah C NA 0 A protein NA calcium-transporting atpase type 2c member 1 TRANSPORT PROTEIN 03/22/23 CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 2 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Chen, Z., Watanabe, S., Inaba, K. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yai C NA 0 A protein NA calcium-transporting atpase type 2c member 1 TRANSPORT PROTEIN 03/22/23 CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 3 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Chen, Z., Watanabe, S., Inaba, K. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yaj C NA 0 A protein NA calcium-transporting atpase type 2c member 1 TRANSPORT PROTEIN 03/22/23 CryoEM structure of SPCA1a in E1-Mn-AMPPCP state subclass 1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Chen, Z., Watanabe, S., Inaba, K. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yon S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/22/23 Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Kang, H., Park, C., Kim, J., Choi, H.-J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yoo S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/22/23 Complex structure of Neuropeptide Y Y2 receptor in complex with NPY and Gi Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Kang, H., Park, C., Kim, J., Choi, H.-J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8bbn M N 0 Y protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-10 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.58 X-RAY DIFFRACTION 0.314 0.265 False True IGHV3 IGKV1 Kappa None None None None None 8bbn J K 0 X protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-10 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.58 X-RAY DIFFRACTION 0.314 0.265 False True IGHV3 IGKV1 Kappa None None None None None 8bbn E F 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-10 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.58 X-RAY DIFFRACTION 0.314 0.265 False True IGHV3 IGKV1 Kappa None None None None None 8bbn H L 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-10 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.58 X-RAY DIFFRACTION 0.314 0.265 False True IGHV3 IGKV1 Kappa None None None None None 8bbn C D 0 Y protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-10 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.58 X-RAY DIFFRACTION 0.314 0.265 False True IGHV3 IGKV1 Kappa None None None None None 8bbn A B 0 X protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-10 and EY6A Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.58 X-RAY DIFFRACTION 0.314 0.265 False True IGHV3 IGKV1 Kappa None None None None None 8bbo H L 0 R protein NA spike glycoprotein VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-36 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.75 X-RAY DIFFRACTION 0.252 0.224 False True IGHV4 IGKV1 Kappa None None None None None 8bcz H L 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with Fabs BA.2-36, BA.2-23, EY6A and COVOX-45 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8bcz C D 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with Fabs BA.2-36, BA.2-23, EY6A and COVOX-45 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8bcz E F 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with Fabs BA.2-36, BA.2-23, EY6A and COVOX-45 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8bcz A B 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with Fabs BA.2-36, BA.2-23, EY6A and COVOX-45 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8bzy B NA 0 A protein NA solute carrier family 40 member 1 TRANSPORT PROTEIN 03/22/23 Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation Homo sapiens; synthetic construct synthetic construct homo sapiens Lehmann, E.F., Liziczai, M., Drozdzyk, K., Dutzler, R., Manatschal, C. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c02 B NA 0 A protein NA solute carrier family 40 member 1 TRANSPORT PROTEIN 03/22/23 Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation Homo sapiens; synthetic construct synthetic construct homo sapiens Lehmann, E.F., Liziczai, M., Drozdzyk, K., Dutzler, R., Manatschal, C. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c3v H L 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-13 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.74 X-RAY DIFFRACTION 0.258 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8c3v A B 0 X protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-13 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.74 X-RAY DIFFRACTION 0.258 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8c3v C D 0 Y protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-13 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.74 X-RAY DIFFRACTION 0.258 0.216 False True IGHV3 IGKV1 Kappa None None None None None 8c3v I NA 0 R protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-13 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.74 X-RAY DIFFRACTION 0.258 0.216 False True IGHV1 NA NA None None None None None 8c3v J NA 0 X protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-13 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.74 X-RAY DIFFRACTION 0.258 0.216 False True IGHV1 NA NA None None None None None 8c3v K NA 0 Y protein NA spike protein s1 VIRAL PROTEIN 03/22/23 SARS-CoV-2 Delta-RBD complexed with BA.2-13 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.74 X-RAY DIFFRACTION 0.258 0.216 False True IGHV1 NA NA None None None None None 8d0z H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/22/23 S728-1157 IgG in complex with SARS-CoV-2-6P-Mut7 Spike protein (focused refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8f76 N NA 0 X | Y | Z protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 03/22/23 Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Billesboelle, C.B., Manglik, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8gng H L 0 A protein NA adenosine receptor a2a MEMBRANE PROTEIN/IMMUNE SYSTEM 03/22/23 Crystal structure of human adenosine A2A receptor in complex with istradefylline. Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Suzuki, M., Saito, J., Miyagi, H., Yasunaga, M. 3.2 X-RAY DIFFRACTION 0.277 0.218 False False IGHV1 IGKV12 Kappa None None None None None 8gng Z Y 0 X protein NA adenosine receptor a2a MEMBRANE PROTEIN/IMMUNE SYSTEM 03/22/23 Crystal structure of human adenosine A2A receptor in complex with istradefylline. Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Suzuki, M., Saito, J., Miyagi, H., Yasunaga, M. 3.2 X-RAY DIFFRACTION 0.277 0.218 False False IGHV1 IGKV12 Kappa None None None None None 8hbd H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/22/23 Cryo-EM structure of IRL1620-bound ETBR-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yuan, Q., Ji, Y., Jiang, Y., Duan, J., Xu, H.E. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hcq E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/22/23 Cryo-EM structure of endothelin1-bound ETAR-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yuan, Q., Jiang, Y., Xu, H.E., Ji, Y., Duan, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hcx E e 0 B | A protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(q) subunit alpha-1 MEMBRANE PROTEIN 03/22/23 Cryo-EM structure of Endothelin1-bound ETBR-Gq complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yuan, Q., Jiang, Y., Xu, H.E., Ji, Y., Duan, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8eqb A NA 0 C | B protein | protein NA | NA isoform 2 of brca2 and cdkn1a-interacting protein | terminal nucleotidyltransferase 5c NUCLEAR PROTEIN 03/15/23 FAM46C/BCCIPalpha/Nanobody complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, S., Chen, H., Yin, Y., Bai, X., Zhang, X. 6.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8eqb D NA 0 F | E protein | protein NA | NA isoform 2 of brca2 and cdkn1a-interacting protein | terminal nucleotidyltransferase 5c NUCLEAR PROTEIN 03/15/23 FAM46C/BCCIPalpha/Nanobody complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, S., Chen, H., Yin, Y., Bai, X., Zhang, X. 6.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8eqb G NA 0 I | H protein | protein NA | NA isoform 2 of brca2 and cdkn1a-interacting protein | terminal nucleotidyltransferase 5c NUCLEAR PROTEIN 03/15/23 FAM46C/BCCIPalpha/Nanobody complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, S., Chen, H., Yin, Y., Bai, X., Zhang, X. 6.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8eqb J NA 0 L | K protein | protein NA | NA isoform 2 of brca2 and cdkn1a-interacting protein | terminal nucleotidyltransferase 5c NUCLEAR PROTEIN 03/15/23 FAM46C/BCCIPalpha/Nanobody complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Liu, S., Chen, H., Yin, Y., Bai, X., Zhang, X. 6.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8emy G NA 0 A protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 82 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.7 X-RAY DIFFRACTION 0.200 0.177 False True IGHV3 NA NA None None None None None 8emy H NA 0 C protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 82 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.7 X-RAY DIFFRACTION 0.200 0.177 False True IGHV3 NA NA None None None None None 8emy I NA 0 F protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 82 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.7 X-RAY DIFFRACTION 0.200 0.177 False True IGHV3 NA NA None None None None None 8emy J NA 0 B protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 82 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.7 X-RAY DIFFRACTION 0.200 0.177 False True IGHV3 NA NA None None None None None 8emy K NA 0 D protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 82 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.7 X-RAY DIFFRACTION 0.200 0.177 False True IGHV3 NA NA None None None None None 8emy L NA 0 E protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 82 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.7 X-RAY DIFFRACTION 0.200 0.177 False True IGHV3 NA NA None None None None None 8en5 E NA 0 A protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of Nanobody 56 in complex with dominant norovirus Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.6 X-RAY DIFFRACTION 0.219 0.186 False True IGHV1 NA NA None None None None None 8en5 F NA 0 B protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of Nanobody 56 in complex with dominant norovirus Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.6 X-RAY DIFFRACTION 0.219 0.186 False True IGHV1 NA NA None None None None None 8en5 G NA 0 C protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of Nanobody 56 in complex with dominant norovirus Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.6 X-RAY DIFFRACTION 0.219 0.186 False True IGHV1 NA NA None None None None None 8en5 H NA 0 D protein NA gii.4 p domain VIRAL PROTEIN 01/08/09 Structure of Nanobody 56 in complex with dominant norovirus Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.6 X-RAY DIFFRACTION 0.219 0.186 False True IGHV1 NA NA None None None None None 8en6 C NA 0 A protein NA gii.17 p domain VIRAL PROTEIN 01/08/09 Structure of GII.17 norovirus in complex with Nanobody 76 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.6 X-RAY DIFFRACTION 0.194 0.173 False True IGHV1 NA NA None None None None None 8en6 D NA 0 B protein NA gii.17 p domain VIRAL PROTEIN 01/08/09 Structure of GII.17 norovirus in complex with Nanobody 76 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.6 X-RAY DIFFRACTION 0.194 0.173 False True IGHV1 NA NA None None None None None 8en4 C NA 0 B protein NA vp1 VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 53 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Koromyslova, A., Pancera, M., Hansman, G. 2.3 X-RAY DIFFRACTION 0.248 0.215 False True IGHV1 NA NA None None None None None 8en4 D NA 0 A protein NA vp1 VIRAL PROTEIN 01/08/09 Structure of GII.4 norovirus in complex with Nanobody 53 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Koromyslova, A., Pancera, M., Hansman, G. 2.3 X-RAY DIFFRACTION 0.248 0.215 False True IGHV1 NA NA None None None None None 7txt C D 0 S protein NA sodium-dependent serotonin transporter TRANSPORT PROTEIN 03/15/23 Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Singh, I., Seth, A., Billesboelle, C.B., Braz, J., Rodriguiz, R.M., Roy, K., Bekele, B., Craik, V., Huang, X.P., Boytsov, D., Lak, P., O'Donnell, H., Sandtner, W., Roth, B.L., Basbaum, A.I., Wetsel, W.C., Manglik, A., Shoichet, B.K., Rudnick, G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7u8e H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/15/23 Crystal structure of antibody Ab246 in complex with SARS-CoV-2 receptor binding domain Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 2.29 X-RAY DIFFRACTION 0.248 0.204 False True IGHV4 IGLV5 Lambda None None None None None 7xdl E D 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/15/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Yuanzhu, G. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xdl G F 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/15/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Yuanzhu, G. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xdl I H 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/15/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Yuanzhu, G. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xdl K J 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/15/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Yuanzhu, G. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7xdl M L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/15/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Yuanzhu, G. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7xdl P O 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/15/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Yuanzhu, G. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 8b01 C NA 0 B | A protein | protein NA | NA putative trap-type c4-dicarboxylate transport system, largepermease component | putative trap-type c4-dicarboxylate transport system, smallpermease component TRANSPORT PROTEIN 03/15/23 Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Photobacterium profundum in a nanodisc Helicobacter pylori; Photobacterium profundum SS9; synthetic construct helicobacter pylori, synthetic construct photobacterium profundum ss9 | photobacterium profundum ss9 Davies, J.S., North, R.A., Dobson, R.C.J. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8c3l B NA 0 A protein NA phage repressor protein ci DNA BINDING PROTEIN 03/15/23 PaaR2 N-terminal domain in complex with nanobody 33 Escherichia coli O157:H7; Lama glama lama glama escherichia coli o157 Loris, R., Prolic-Kalinsek, M. 1.5971 X-RAY DIFFRACTION 0.254 0.219 False True IGHV1 NA NA None None None None None 8c3l D NA 0 C protein NA phage repressor protein ci DNA BINDING PROTEIN 03/15/23 PaaR2 N-terminal domain in complex with nanobody 33 Escherichia coli O157:H7; Lama glama lama glama escherichia coli o157 Loris, R., Prolic-Kalinsek, M. 1.5971 X-RAY DIFFRACTION 0.254 0.219 False True IGHV1 NA NA None None None None None 8ek1 A B 0 P peptide NA circumsporozoite protein IMMUNE SYSTEM 03/15/23 Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class) Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ek1 C D 0 P peptide NA circumsporozoite protein IMMUNE SYSTEM 03/15/23 Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class) Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8ek1 H L 0 P peptide NA circumsporozoite protein IMMUNE SYSTEM 03/15/23 Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class) Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8eka H L 0 P peptide NA circumsporozoite protein IMMUNE SYSTEM 03/15/23 Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(class 2) Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8eka A B 0 P peptide NA circumsporozoite protein IMMUNE SYSTEM 03/15/23 Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(class 2) Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8eka C D 0 P peptide NA circumsporozoite protein IMMUNE SYSTEM 03/15/23 Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(class 2) Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Tripathi, P., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8emz B NA 0 A protein NA gii.17 p domain VIRAL PROTEIN 03/15/23 Structure of GII.17 norovirus in complex with Nanobody 2 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 1.4 X-RAY DIFFRACTION 0.220 0.195 False True IGHV1 NA NA None None None None None 8en0 D NA 0 A protein NA capsid protein vp1 VIRAL PROTEIN 03/15/23 Structure of GII.17 norovirus in complex with Nanobody 7 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Koromyslova, A., Pancera, M., Hansman, G. 2.99 X-RAY DIFFRACTION 0.306 0.249 False True IGHV1 NA NA None None None None None 8en2 C NA 0 B protein NA gii.10 p domain VIRAL PROTEIN 03/15/23 Structure of GII.10 norovirus in complex with Nanobody 34 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Koromyslova, A., Pancera, M., Hansman, G. 1.85 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 8en2 D NA 0 A protein NA gii.10 p domain VIRAL PROTEIN 03/15/23 Structure of GII.10 norovirus in complex with Nanobody 34 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Koromyslova, A., Pancera, M., Hansman, G. 1.85 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 8en3 C NA 0 A protein NA capsid protein vp1 VIRAL PROTEIN 03/15/23 Structure of GII.17 norovirus in complex with Nanobody 45 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 2.1 X-RAY DIFFRACTION 0.263 0.213 False True IGHV1 NA NA None None None None None 8en3 D NA 0 B protein NA capsid protein vp1 VIRAL PROTEIN 03/15/23 Structure of GII.17 norovirus in complex with Nanobody 45 Norovirus; Vicugna pacos vicugna pacos norovirus Kher, G., Sabin, C., Pancera, M., Koromyslova, A., Hansman, G. 2.1 X-RAY DIFFRACTION 0.263 0.213 False True IGHV1 NA NA None None None None None 8hix N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/15/23 GPR21_m5_Gs Homo sapiens homo sapiens homo sapiens | homo sapiens Chen, B., Lin, X., Xu, F. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8hj0 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/15/23 GPR21(m5) and G15 complex Homo sapiens homo sapiens homo sapiens | homo sapiens Chen, B., Lin, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8hj2 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/15/23 GPR21 wt with G15 complex Homo sapiens homo sapiens homo sapiens | homo sapiens Chen, B., Lin, X., Xu, F. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8id3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/15/23 Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8id4 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/15/23 Cryo-EM structure of the linoleic acid bound GPR120-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8id6 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/15/23 Cryo-EM structure of the oleic acid bound GPR120-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8id8 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/15/23 Cryo-EM structure of the TUG891 bound GPR120-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8id9 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/15/23 Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7x08 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 S protein of SARS-CoV-2 in complex with 2G1 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7x08 I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 S protein of SARS-CoV-2 in complex with 2G1 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7x08 J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 S protein of SARS-CoV-2 in complex with 2G1 Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6vug D C 0 B protein NA reverse transcriptase p51 PROTEIN BINDING 02/17/21 Diabody bound to a Reverse Transcriptase Aptamer Complex Homo sapiens; Human immunodeficiency virus 1; Human immunodeficiency virus type 1 homo sapiens homo sapiens human immunodeficiency virus 1 Chesterman, C., Arnold, E. 3 X-RAY DIFFRACTION 0.255 0.202 False True IGHV3 IGKV1 Kappa None None None None None 7o4y H L 0 NA NA NA NA IMMUNE SYSTEM 07/28/21 m971 Fab in complex with anti-Kappa VHH domain Homo sapiens; Lama glama homo sapiens homo sapiens Ereno-Orbea, J., Sicard, T., Julien, J.P. 1.6 X-RAY DIFFRACTION 0.246 0.219 False True IGHV6 IGKV1 Kappa None None None None None 7sof H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S NTD B.1.617.1 kappa variant S2X303 Local Refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.6 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 7v64 B A 0 C peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/24/22 Crystal structure of Antibody 16A in complex with MUC1 Glycopeptide(GlycoT) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 1.56 X-RAY DIFFRACTION 0.203 0.179 False True IGHV4 IGLV1 Lambda None None None None None 7soe B L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S B.1.617.1 kappa variant + S2X303 Global Refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 7soe E D 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S B.1.617.1 kappa variant + S2X303 Global Refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 7soe H G 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-CoV-2 S B.1.617.1 kappa variant + S2X303 Global Refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 7lx3 H L 0 A protein NA env glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of EDC-crosslinked ConSOSL.UFO.664 (ConS-EDC) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lx3 N M 0 B protein NA env glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of EDC-crosslinked ConSOSL.UFO.664 (ConS-EDC) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lx3 P O 0 C protein NA env glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of EDC-crosslinked ConSOSL.UFO.664 (ConS-EDC) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7ru8 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 08/24/22 CC6.30 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (RBD/Fv local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7s5q B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibodies CS44 and COVA1-16 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.88 X-RAY DIFFRACTION 0.257 0.216 False True IGHV1 IGKV3 Kappa None None None None None 7s5q H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibodies CS44 and COVA1-16 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.88 X-RAY DIFFRACTION 0.257 0.216 False True IGHV1 IGKV1 Kappa None None None None None 7ru5 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 08/24/22 CC6.30 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7ru5 D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 08/24/22 CC6.30 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7e9o H L 0 A protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/09/22 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(3 up RBDs, state2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7e9o P O 0 B protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/09/22 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(3 up RBDs, state2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7e9o Y X 0 C protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/09/22 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(3 up RBDs, state2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7ru4 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 08/24/22 CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (RBD/Fv local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8ekf H L 0 C peptide NA unknown IMMUNE SYSTEM 01/08/09 X-ray crystal structure of 311R Fab in complex with the PfCSP peptide NPNA-3 Homo sapiens; SYNTHETIC CONSTRUCT Moskovitz, R., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.222 0.184 False False IGHV3 IGLV1 Lambda None None None None None 7ru6 L NA 0 A protein NA serine incorporator 3 MEMBRANE PROTEIN 08/24/22 Cryo-EM structure of the HIV-1 restriction factor human SERINC3 Homo sapiens; synthetic construct synthetic construct homo sapiens Purdy, M.D., Leonhardt, S.A., Yeager, M. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7x9y S s 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 08/24/22 Cryo-EM structure of the apo CCR3-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Shao, Z., Tan, Y., Shen, Q., Yao, B., Hou, L., Qin, J., Xu, P., Mao, C., Chen, L., Zhang, H., Shen, D., Zhang, C., Li, W., Du, X., Li, F., Chen, Z., Jiang, Y., Xu, H.E., Ying, S., Ma, H., Zhang, Y., Shen, H. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7txz E F 0 A protein NA glycoprotein g VIRAL PROTEIN 03/09/22 Nipah Virus attachment (G) glycoprotein ectodomain in complex with nAH1.3 neutralizing antibody Fab fragment (local refinement of the distal region) Mus sp.; Nipah henipavirus mus sp. mus sp. nipah henipavirus Wang, Z.Q., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV3 Kappa None None None None None 7txz H L 0 B protein NA glycoprotein g VIRAL PROTEIN 03/09/22 Nipah Virus attachment (G) glycoprotein ectodomain in complex with nAH1.3 neutralizing antibody Fab fragment (local refinement of the distal region) Mus sp.; Nipah henipavirus mus sp. mus sp. nipah henipavirus Wang, Z.Q., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV3 Kappa None None None None None 4q9q H L 0 R nucleic-acid NA spinach rna aptamer RNA 06/18/14 Crystal structure of an RNA aptamer bound to bromo-ligand analog in complex with Fab Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Huang, H., Suslov, N.B., Li, N.-S., Shelke, S.A., Evans, M.E., Koldobskaya, Y., Rice, P.A., Piccirilli, J.A. 2.45 X-RAY DIFFRACTION 0.221 0.182 False True IGHV3 IGKV1 Kappa None None None None None 7e9q H L 0 A protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/09/22 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 out RBD, state3) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7e9q Y X 0 C protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/09/22 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 out RBD, state3) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7e9q F E 0 B protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/09/22 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 out RBD, state3) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7u0k H L 0 NA NA NA NA IMMUNE SYSTEM 08/24/22 IOMA class antibody Fab ACS124 Homo sapiens homo sapiens homo sapiens Farokhi, E., Stanfield, R.L., Wilson, I.A. 1.73 X-RAY DIFFRACTION 0.223 0.186 False True IGHV4 IGLV3 Lambda None None None None None 7u04 H L 0 NA NA NA NA IMMUNE SYSTEM 08/24/22 IOMA class antibody ACS101 Homo sapiens homo sapiens homo sapiens Farokhi, E., Stanfield, R.L., Wilson, I.A. 2.31 X-RAY DIFFRACTION 0.256 0.217 False True IGHV1 IGLV2 Lambda None None None None None 7v5k E D 0 A protein NA spike glycoprotein PROTEIN BINDING 08/24/22 MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v5k G F 0 C protein NA spike glycoprotein PROTEIN BINDING 08/24/22 MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v5k I H 0 B protein NA spike glycoprotein PROTEIN BINDING 08/24/22 MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7mlx H L 0 R nucleic-acid NA rna (65-mer) RNA/IMMUNE SYSTEM 08/11/21 SARS-CoV-2 programmed -1 frameshifting element three stem H-type pseudoknot Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Roman, C., Lewicka, A. 2.09 X-RAY DIFFRACTION 0.231 0.199 False True IGHV3 IGKV1 Kappa None None None None None 4q9r H L 0 R nucleic-acid NA spinach rna aptamer RNA/immune system 06/18/14 Crystal structure of an RNA aptamer bound to trifluoroethyl-ligand analog in complex with Fab Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Huang, H., Suslov, N.B., Li, N.-S., Shelke, S.A., Evans, M.E., Koldobskaya, Y., Rice, P.A., Piccirilli, J.A. 3.12 X-RAY DIFFRACTION 0.253 0.203 False True IGHV3 IGKV1 Kappa None None None None None 7t10 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/SIGNALING PROTEIN 03/09/22 CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Robertson, M.J., Skinotis, G. 2.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7lx2 H L 0 A protein NA env glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of ConSOSL.UFO.664 (ConS) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lx2 N M 0 B protein NA env glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of ConSOSL.UFO.664 (ConS) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lx2 P O 0 C protein NA env glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of ConSOSL.UFO.664 (ConS) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7rug L NA 0 A protein NA serine incorporator 3 UNKNOWN FUNCTION 08/24/22 Human SERINC3-DeltaICL4 Homo sapiens; synthetic construct synthetic construct homo sapiens Purdy, M.D., Leonhardt, S.A., Yeager, M. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wsl H L 0 D protein NA programmed cell death protein 1 IMMUNE SYSTEM 08/24/22 PD-1 in complex with Dostarlimab Homo sapiens homo sapiens homo sapiens homo sapiens Heo, Y.S. 1.534 X-RAY DIFFRACTION 0.178 0.161 False True IGHV3 IGKV1 Kappa None None None None None 7vkt E e 0 B | D | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/09/22 cryo-EM structure of LTB4-bound BLT1 in complex with Gi protein Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens He, Y., Wang, N. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7lxm H L 0 A protein NA hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of ConM SOSIP.v7 (ConM) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lxm N M 0 C protein NA hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of ConM SOSIP.v7 (ConM) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lxm P O 0 E protein NA hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of ConM SOSIP.v7 (ConM) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7ty0 J N 0 D protein NA glycoprotein g VIRAL PROTEIN 03/09/22 Nipah Virus attachment (G) glycoprotein ectodomain in complex with nAH1.3 neutralizing antibody Fab fragment (local refinement of the stalk region) Mus sp.; Nipah henipavirus mus sp. mus sp. nipah henipavirus Wang, Z.Q., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV3 Kappa None None None None None 7ty0 K O 0 C protein NA glycoprotein g VIRAL PROTEIN 03/09/22 Nipah Virus attachment (G) glycoprotein ectodomain in complex with nAH1.3 neutralizing antibody Fab fragment (local refinement of the stalk region) Mus sp.; Nipah henipavirus mus sp. mus sp. nipah henipavirus Wang, Z.Q., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV3 Kappa None None None None None 7ryc E e 0 D | C protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2, guanine nucleotide-binding protein g(i) subunit alpha-2, guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/NEUROPEPTIDE 03/09/22 Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Meyerowitz, J.G., Robertson, M.J., Skiniotis, G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7t3m D L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 S (Spike Glycoprotein) D614G with Three (3) RBDs Up, Bound to Antibody 2-7 scFv, composite map Escherichia coli; Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV6 Lambda None None None None None 7t3m H J 0 G protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 S (Spike Glycoprotein) D614G with Three (3) RBDs Up, Bound to Antibody 2-7 scFv, composite map Escherichia coli; Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV6 Lambda None None None None None 7t3m I K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 S (Spike Glycoprotein) D614G with Three (3) RBDs Up, Bound to Antibody 2-7 scFv, composite map Escherichia coli; Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 Byrne, P.O., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV6 Lambda None None None None None 7lxn H L 0 A protein NA hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of EDC-crosslinked ConM SOSIP.v7 (ConM-EDC) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lxn I M 0 C protein NA hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of EDC-crosslinked ConM SOSIP.v7 (ConM-EDC) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7lxn J N 0 E protein NA hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Cryo-EM structure of EDC-crosslinked ConM SOSIP.v7 (ConM-EDC) in complex with bNAb PGT122 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Martin, G.M., Ward, A.B., Sattentau, Q.J. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7s5p H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibody CS23 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.86 X-RAY DIFFRACTION 0.247 0.208 False True IGHV3 IGLV3 Lambda None None None None None 7ru3 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 08/24/22 CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7ru3 E F 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 08/24/22 CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Turner, H.L., Ward, A.B. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7t11 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/SIGNALING PROTEIN 03/09/22 CryoEM structure of somatostatin receptor 2 in complex with Octreotide and Gi3. Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Robertson, M.J., Skinotis, G. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7rfp H L 0 A protein NA tumor necrosis factor receptor superfamily member 18,enhanced green fluorescent protein IMMUNE SYSTEM 03/09/22 Mouse GITR (mGITR) with DTA-1 Fab fragment Muromegalovirus G4; Mus musculus mus musculus mus musculus mus musculus, muromegalovirus g4 Meyerson, J.R., He, C. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV5 unknown unknown None None None None None 7rfp I M 0 B protein NA tumor necrosis factor receptor superfamily member 18,enhanced green fluorescent protein IMMUNE SYSTEM 03/09/22 Mouse GITR (mGITR) with DTA-1 Fab fragment Muromegalovirus G4; Mus musculus mus musculus mus musculus mus musculus, muromegalovirus g4 Meyerson, J.R., He, C. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV5 unknown unknown None None None None None 6wjl H L 0 G protein NA glypican-2 Oncoprotein/Immune System 04/21/21 Crystal structure of Glypican-2 core protein in complex with D3 Fab Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Raman, S., Maris, J.M., Bosse, K.R., Julien, J.P. 3.3 X-RAY DIFFRACTION 0.317 0.278 False True IGHV3 IGKV1 Kappa None None None None None 6wjl F J 0 E protein NA glypican-2 Oncoprotein/Immune System 04/21/21 Crystal structure of Glypican-2 core protein in complex with D3 Fab Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Raman, S., Maris, J.M., Bosse, K.R., Julien, J.P. 3.3 X-RAY DIFFRACTION 0.317 0.278 False True IGHV3 IGKV1 Kappa None None None None None 4cc8 F J 0 D protein NA gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/30/13 Pre-fusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Bartesaghi, A., Merk, A., Borgnia, M.J., Milne, J.L.S., Subramaniam, S. 6 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 4cc8 H L 0 E protein NA gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/30/13 Pre-fusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Bartesaghi, A., Merk, A., Borgnia, M.J., Milne, J.L.S., Subramaniam, S. 6 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 4cc8 I K 0 G protein NA gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/30/13 Pre-fusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Bartesaghi, A., Merk, A., Borgnia, M.J., Milne, J.L.S., Subramaniam, S. 6 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7xa3 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 Cryo-EM structure of the CCL2 bound CCR2-Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens Shao, Z., Tan, Y., Shen, Q., Yao, B., Hou, L., Qin, J., Xu, P., Mao, C., Chen, L., Zhang, H., Shen, D., Zhang, C., Li, W., Du, X., Li, F., Chen, Z., Jiang, Y., Xu, H.E., Ying, S., Ma, H., Zhang, Y., Shen, H. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ph4 C NA 0 B protein NA atp-dependent lipid a-core flippase MEMBRANE PROTEIN 08/24/22 AMP-PNP bound nanodisc reconstituted MsbA with nanobodies, spin-labeled at position T68C Escherichia coli (strain K12); Vicugna pacos vicugna pacos escherichia coli (strain k12) Parey, K., Januliene, D., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ph4 D NA 0 A protein NA atp-dependent lipid a-core flippase MEMBRANE PROTEIN 08/24/22 AMP-PNP bound nanodisc reconstituted MsbA with nanobodies, spin-labeled at position T68C Escherichia coli (strain K12); Vicugna pacos vicugna pacos escherichia coli (strain k12) Parey, K., Januliene, D., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7v7k B A 0 C peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/24/22 Crystal structure of Antibody 16A in complex with MUC1 Glycopeptide(GlycoST) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 2.2 X-RAY DIFFRACTION 0.251 0.201 False True IGHV4 IGLV1 Lambda None None None None None 7s5r H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibodies CV07-287 and COVA1-16 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 IGKV1 Kappa None None None None None 7s5r B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibodies CV07-287 and COVA1-16 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 IGKV3 Kappa None None None None None 8hsc S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/08/23 Gi bound Orphan GPR20 complex with Fab046 in ligand-free state Escherichia coli; Homo sapiens; Rattus; Vicugna pacos vicugna pacos homo sapiens | homo sapiens Lin, X., Jiang, S., Xu, F. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hsc F E 0 R protein NA soluble cytochrome b562,g-protein coupled receptor 20 MEMBRANE PROTEIN 03/08/23 Gi bound Orphan GPR20 complex with Fab046 in ligand-free state Escherichia coli; Homo sapiens; Rattus; Vicugna pacos rattus rattus escherichia coli, homo sapiens Lin, X., Jiang, S., Xu, F. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7ul0 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 03/08/23 Crystal structure of SARS-CoV-2 RBD in complex with the ridge-binding nAb EH8 isolated from a nonvaccinated pediatric patient Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, Y., Tolbert, W.D., Bai, X., Pazgier, M. 2.49 X-RAY DIFFRACTION 0.256 0.225 False True IGHV1 IGLV2 Lambda None None None None None 7ul1 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 03/08/23 Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing IGHV3-53-encoded antibody EH3 isolated from a nonvaccinated pediatric patient Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Chen, Y., Tolbert, W.D., Pazgier, M. 2.65 X-RAY DIFFRACTION 0.221 0.174 False True IGHV3 IGKV3 Kappa None None None None None 7wp8 D C 0 F protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 03/08/23 Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK1628x in complex with three neutralizing antibodies Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Yuan, Q., Li, S., Xia, N. 3.88 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 7wp8 E G 0 F protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 03/08/23 Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK1628x in complex with three neutralizing antibodies Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Yuan, Q., Li, S., Xia, N. 3.88 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 7wp8 H L 0 F protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 03/08/23 Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK1628x in complex with three neutralizing antibodies Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Yuan, Q., Li, S., Xia, N. 3.88 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 7x63 H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/08/23 SARS-CoV-2-Beta-RBD and BD-236-GWP/P-VK antibody complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J. 2.24 X-RAY DIFFRACTION 0.224 0.193 False True IGHV3 IGKV1 Kappa None None None None None 7x66 H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/08/23 SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shi, R., Wang, Y., Wu, Z., Han, X., Yan, J. 2.4 X-RAY DIFFRACTION 0.238 0.190 False True IGHV3 IGKV1 Kappa None None None None None 8bev B NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/08/23 Cryo-EM structure of SARS-CoV-2 spike (HexaPro variant) in complex with nanobody W25 (map 3, focus refinement on RBD, W25 and adjacent NTD) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Lauer, S., Spahn, C.M.T., Schwefel, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8bgg Y NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/08/23 Cryo-EM structure of SARS-CoV-2 spike (Omicron BA.1 variant) in complex with nanobody W25 (map 5, focus refinement on RBD, W25 and adjacent NTD) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Modhiran, N., Lauer, S., Spahn, C.M.T., Watterson, D., Schwefel, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8f5n H L 0 A protein NA t18.1 major pilin backbone protein t-antigen STRUCTURAL PROTEIN 03/08/23 Identification of an Immunodominant region on a Group A Streptococcus T-antigen Reveals Temperature-Dependent Motion in Pili Homo sapiens; Streptococcus pyogenes homo sapiens homo sapiens streptococcus pyogenes Raynes, J.M., Young, P.G., Moreland, N.J. 1.9 X-RAY DIFFRACTION 0.244 0.202 False True IGHV1 IGKV10 Kappa None None None None None 8ffe H L 0 A protein NA low-density lipoprotein receptor-related protein 6 SIGNALING PROTEIN/Immune System 03/08/23 Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide Homo sapiens homo sapiens homo sapiens homo sapiens Jude, K.M., Tsutsumi, N., Waghray, D., Garcia, K.C. 1.72 X-RAY DIFFRACTION 0.231 0.185 False True IGHV3 IGKV1 Kappa None None None None None 8g59 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/08/23 Cryo-EM structure of the TUG891 bound GPR120-Giq complex Homo sapiens homo sapiens homo sapiens | homo sapiens Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8hs2 B C 0 R protein NA soluble cytochrome b562,g-protein coupled receptor 20 MEMBRANE PROTEIN 03/08/23 Orphan GPR20 in complex with Fab046 Escherichia coli; Homo sapiens; Rattus rattus rattus escherichia coli, homo sapiens Lin, X., Jiang, S., Xu, F. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8hs3 S s 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | ggama MEMBRANE PROTEIN 03/08/23 Gi bound orphan GPR20 in ligand-free state Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Lin, X., Jiang, S., Xu, F. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8c7h L K 0 I | D | C protein | protein | protein NA | NA | NA transforming growth factor beta activator lrrc32 | transforming growth factor beta-1 | transforming growth factor beta-1 IMMUNE SYSTEM 03/01/23 Cryo-EM Map of the latTGF-beta 28G11 Fab complex Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Ebenhoch, R., Nar, H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7u0q G F 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7u0q J I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7tqg H L 0 NA NA NA NA ANTIVIRAL PROTEIN, IMMUNE SYSTEM 03/01/23 Crystal Structure of IOMA Fab inferred germline Homo sapiens homo sapiens homo sapiens Gristick, H.B., Bjorkman, P.J. 2.07 X-RAY DIFFRACTION 0.257 0.224 False True IGHV1 IGLV2 Lambda None None None None None 7u0x F G 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/01/23 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-13 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7u0x H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/01/23 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-13 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wp6 B I 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK in complex with three neutralizing antibodies Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Yuan, Q., Li, S., Xia, N. 3.81 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 7wp6 D C 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK in complex with three neutralizing antibodies Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Yuan, Q., Li, S., Xia, N. 3.81 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 7wp6 H L 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK in complex with three neutralizing antibodies Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Yuan, Q., Li, S., Xia, N. 3.81 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 7wsc H L 0 R protein NA spike protein s1 VIRAL PROTEIN 03/01/23 Local structure of BD55-3500 and omicron RBD complex Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Liu, P.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7x2h A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/01/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with 6-2C Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.1 X-RAY DIFFRACTION 0.269 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7x2h C D 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/01/23 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with 6-2C Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, Z. 2.1 X-RAY DIFFRACTION 0.269 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7x3n B A 0 B Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 03/01/23 Crystal structure of anti-mPEG h15-2b Fab Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Toh, S.I., Su, Y.C. 2.24 X-RAY DIFFRACTION 0.269 0.205 False True IGHV3 IGKV1 Kappa None None None None None 7x3n D C 0 D Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 03/01/23 Crystal structure of anti-mPEG h15-2b Fab Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Toh, S.I., Su, Y.C. 2.24 X-RAY DIFFRACTION 0.269 0.205 False True IGHV3 IGKV1 Kappa None None None None None 7xcz D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with BA7054 and BA7125 fab (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xcz B C 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with BA7054 and BA7125 fab (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xda B C 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with BA7208 and BA7125 fab (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Liu, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xda D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with BA7208 and BA7125 fab (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Liu, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7xdb D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Omicron Spike protein in complex with BA7208 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Gao, Y.Z. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7xdb G F 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Omicron Spike protein in complex with BA7208 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Gao, Y.Z. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7xdb I H 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Omicron Spike protein in complex with BA7208 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Liu, S., Gao, Y.Z. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7xdk F G 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Lui, S., Gao, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xdk D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Lui, S., Gao, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xdk K J 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Lui, S., Gao, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xdk H I 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Lui, S., Gao, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xdk L M 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Lui, S., Gao, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7xdk N O 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/01/23 Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Z., Lui, S., Gao, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7y64 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/01/23 Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Feng, Y.Y., Zhao, C., Yan, W., Shao, Z.H. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y65 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/01/23 Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Feng, Y.Y., Zhao, C., Yan, W., Shao, Z.H. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y66 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/01/23 Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Feng, Y.Y., Zhao, C., Yan, W., Shao, Z.H. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y67 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/01/23 Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Feng, Y.Y., Zhao, C., Yan, W., Shao, Z.H. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yj4 S s 0 T | I protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i) subunit alpha-2 STRUCTURAL PROTEIN 03/01/23 Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4 (RXFP4)-Gi complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Chen, Y., Zhou, Q.T., Wang, J., Xu, Y.W., Wang, Y., Yan, J.H., Wang, Y.B., Zhu, Q., Zhao, F.H., Li, C.H., Chen, C.W., Cai, X.Q., Bathgate, R.A.D., Shen, C., Liu, H., Xu, H.E., Yang, D.H., Wang, M.W. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yk6 S s 0 I | T protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 03/01/23 Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Chen, Y., Zhou, Q.T., Wang, J., Xu, Y.W., Wang, Y., Yan, J.H., Wang, Y.B., Zhu, Q., Zhao, F.H., Li, C.H., Chen, C.W., Cai, X.Q., Bathgate, R.A.D., Shen, C., Liu, H., Xu, H.E., Yang, D.H., Wang, M.W. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yk7 S s 0 I | T | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 03/01/23 Cryo-EM structure of the DC591053-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex Bos taurus; Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | bos taurus Chen, Y., Zhou, Q.T., Wang, J., Xu, Y.W., Wang, Y., Yan, J.H., Wang, Y.B., Zhu, Q., Zhao, F.H., Li, C.H., Chen, C.W., Cai, X.Q., Bathgate, R.A.D., Shen, C., Xu, H.E., Yang, D.H., Liu, H., Wang, M.W. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yzw A NA 0 NA NA NA NA IMMUNE SYSTEM 03/01/23 Llama nanobody VHH15 raised against the glycoprotein of Ebola virus Lama glama lama glama Coulibaly, A.B., Roussel, A., Leone, P. 1.6 X-RAY DIFFRACTION 0.213 0.190 False True IGHV1 NA NA None None None None None 7yzw B NA 0 NA NA NA NA IMMUNE SYSTEM 03/01/23 Llama nanobody VHH15 raised against the glycoprotein of Ebola virus Lama glama lama glama Coulibaly, A.B., Roussel, A., Leone, P. 1.6 X-RAY DIFFRACTION 0.213 0.190 False True IGHV1 NA NA None None None None None 7yzw C NA 0 NA NA NA NA IMMUNE SYSTEM 03/01/23 Llama nanobody VHH15 raised against the glycoprotein of Ebola virus Lama glama lama glama Coulibaly, A.B., Roussel, A., Leone, P. 1.6 X-RAY DIFFRACTION 0.213 0.190 False True IGHV1 NA NA None None None None None 7yzw D NA 0 NA NA NA NA IMMUNE SYSTEM 03/01/23 Llama nanobody VHH15 raised against the glycoprotein of Ebola virus Lama glama lama glama Coulibaly, A.B., Roussel, A., Leone, P. 1.6 X-RAY DIFFRACTION 0.213 0.190 False True IGHV1 NA NA None None None None None 7yzw E NA 0 NA NA NA NA IMMUNE SYSTEM 03/01/23 Llama nanobody VHH15 raised against the glycoprotein of Ebola virus Lama glama lama glama Coulibaly, A.B., Roussel, A., Leone, P. 1.6 X-RAY DIFFRACTION 0.213 0.190 False True IGHV1 NA NA None None None None None 7yzw F NA 0 NA NA NA NA IMMUNE SYSTEM 03/01/23 Llama nanobody VHH15 raised against the glycoprotein of Ebola virus Lama glama lama glama Coulibaly, A.B., Roussel, A., Leone, P. 1.6 X-RAY DIFFRACTION 0.213 0.190 False True IGHV1 NA NA None None None None None 7zmk B C 0 D protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7zmk E F 0 A protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7zmk G H 0 I protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7zmk J K 0 L protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7zmk M N 0 O protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7zmk P Q 0 R protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7zmk S T 0 U protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7zmk V W 0 X protein NA microfibril-associated glycoprotein 4 CELL ADHESION 03/01/23 Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Laursen, N.S., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.277 0.239 False True IGHV1 IGKV1 Kappa None None None None None 8ath E F 0 B protein NA lysosome-associated membrane glycoprotein 1 PROTEIN BINDING 03/01/23 CRYSTAL STRUCTURE OF LAMP1 IN COMPLEX WITH FAB-B. Homo sapiens homo sapiens homo sapiens homo sapiens Mathieu, M., Dupuy, A. 2.366 X-RAY DIFFRACTION 0.290 0.251 False True IGHV1 IGKV19 Kappa None None None None None 8ath H L 0 A protein NA lysosome-associated membrane glycoprotein 1 PROTEIN BINDING 03/01/23 CRYSTAL STRUCTURE OF LAMP1 IN COMPLEX WITH FAB-B. Homo sapiens homo sapiens homo sapiens homo sapiens Mathieu, M., Dupuy, A. 2.366 X-RAY DIFFRACTION 0.290 0.251 False True IGHV1 IGKV19 Kappa None None None None None 8df1 M N 0 B protein NA chitinase-3-like protein 1 IMMUNE SYSTEM 03/01/23 Chi3l1 bound by antibody C59 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Wrapp, D., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.243 0.206 False True IGHV1 IGKV1 Kappa None None None None None 8df1 H L 0 A protein NA chitinase-3-like protein 1 IMMUNE SYSTEM 03/01/23 Chi3l1 bound by antibody C59 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Wrapp, D., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.243 0.206 False True IGHV1 IGKV1 Kappa None None None None None 8df1 O P 0 C protein NA chitinase-3-like protein 1 IMMUNE SYSTEM 03/01/23 Chi3l1 bound by antibody C59 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Wrapp, D., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.243 0.206 False True IGHV1 IGKV1 Kappa None None None None None 8df1 Q R 0 D protein NA chitinase-3-like protein 1 IMMUNE SYSTEM 03/01/23 Chi3l1 bound by antibody C59 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Wrapp, D., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.243 0.206 False True IGHV1 IGKV1 Kappa None None None None None 8df1 S T 0 E protein NA chitinase-3-like protein 1 IMMUNE SYSTEM 03/01/23 Chi3l1 bound by antibody C59 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Wrapp, D., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.243 0.206 False True IGHV1 IGKV1 Kappa None None None None None 8df1 U V 0 F protein NA chitinase-3-like protein 1 IMMUNE SYSTEM 03/01/23 Chi3l1 bound by antibody C59 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Wrapp, D., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.243 0.206 False True IGHV1 IGKV1 Kappa None None None None None 8hmv N NA 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/01/23 Structure of GPR21-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Wong, T.S., Gao, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7w3z H h 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/22/23 Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin Releasing Peptide and Gq heterotrimers Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Zhan, Y., Peng, S., Zhang, H. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7w40 H h 0 B | C | D protein | protein | peptide NA | NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/22/23 Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] and Gq heterotrimers Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens | homo sapiens Zhan, Y., Peng, S., Zhang, H. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xk2 S s 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/22/23 Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Yang, Y., Kang, H.J., Gao, R.G., Wang, J.J., Han, G.W., DiBerto, J.F., Wu, L.J., Tong, J.H., Qu, L., Wu, Y.R., Pileski, R., Li, X.M., Zhang, X.C., Zhao, S.W., Kenakin, T., Wang, Q., Stevens, R.C., Peng, W., Roth, B.L., Rao, Z.H., Liu, Z.J. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y7j E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/22/23 SARS-CoV-2 S trimer in complex with 1F Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, S., Liu, F., Yang, X., Zhong, G. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7y7k B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/22/23 SARS-CoV-2 RBD in complex with 1F Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, S., Liu, F., Yang, X., Zhong, G. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 8c8p H NA 0 A protein NA spike glycoprotein,sars-cov-2 spike glycoprotein VIRAL PROTEIN 02/22/23 Structure of the SARS-CoV-2 spike glycoprotein in complex with the 10D12 heavy-chain-only antibody (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus severe acute respiratory syndrome coronavirus2 Serna Martin, I., Hurdiss, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dg8 H L 0 B protein NA fusion glycoprotein f0 IMMUNE SYSTEM 02/22/23 Cryo-EM Structure of HPIV3 prefusion F trimer in complex with 3x1 Fab Homo sapiens; Human parainfluenza 3 virus (strain NIH 47885) homo sapiens homo sapiens human parainfluenza 3 virus (strain nih 47885) Rodarte, J.V., Pancera, M. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8dg9 H L 0 A protein NA fusion glycoprotein f0 IMMUNE SYSTEM 02/22/23 Cryo-EM Structure of RSV prefusion F trimer in complex with three MxR Fabs Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Rodarte, J.V., Pancera, M. 2.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dg9 F G 0 B protein NA fusion glycoprotein f0 IMMUNE SYSTEM 02/22/23 Cryo-EM Structure of RSV prefusion F trimer in complex with three MxR Fabs Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Rodarte, J.V., Pancera, M. 2.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8dg9 D E 0 C protein NA fusion glycoprotein f0 IMMUNE SYSTEM 02/22/23 Cryo-EM Structure of RSV prefusion F trimer in complex with three MxR Fabs Homo sapiens; Respiratory syncytial virus A2 homo sapiens homo sapiens respiratory syncytial virus a2 Rodarte, J.V., Pancera, M. 2.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8a67 D NA 0 A | C | B protein | protein | protein NA | NA | NA polyubiquitin-b | polyubiquitin-b | polyubiquitin-b SIGNALING PROTEIN 02/15/23 Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with matured synthetic nanobody NbSL3.3Q (3rd generation) Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Lange, S.M., Kulathu, Y. 1.86 X-RAY DIFFRACTION 0.245 0.187 False True IGHV1 NA NA None None None None None 8a67 H NA 0 E | G | F protein | protein | protein NA | NA | NA polyubiquitin-b | polyubiquitin-b | polyubiquitin-b SIGNALING PROTEIN 02/15/23 Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with matured synthetic nanobody NbSL3.3Q (3rd generation) Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Lange, S.M., Kulathu, Y. 1.86 X-RAY DIFFRACTION 0.245 0.187 False True IGHV1 NA NA None None None None None 7tmw N NA 0 R | B protein | protein NA | NA relaxin receptor 1, guanine nucleotide-binding protein g(s)subunit alpha isoforms short fusion | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/15/23 Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Erlandson, S.C., Rawson, S., Kruse, A.C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7u9e B b 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AL-26 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.39 X-RAY DIFFRACTION 0.269 0.225 True True unknown unknown unknown None None None None None 7u9e H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AL-26 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.39 X-RAY DIFFRACTION 0.269 0.225 True True unknown unknown unknown None None None None None 7u9w H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-88 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.79 X-RAY DIFFRACTION 0.255 0.224 True True unknown unknown unknown None None None None None 7ua2 B b 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AL-18 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.19 X-RAY DIFFRACTION 0.256 0.222 True True unknown unknown unknown None None None None None 7ua2 H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AL-18 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.19 X-RAY DIFFRACTION 0.256 0.222 True True unknown unknown unknown None None None None None 7ua8 H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AL-20 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.8 X-RAY DIFFRACTION 0.274 0.249 True True unknown unknown unknown None None None None None 7ua8 I i 0 B protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AL-20 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.8 X-RAY DIFFRACTION 0.274 0.249 True True unknown unknown unknown None None None None None 7ubs H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-26 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.250 0.209 True True unknown unknown unknown None None None None None 7ubs I i 0 B protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-26 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.250 0.209 True True unknown unknown unknown None None None None None 7ubs J j 0 C protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-26 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.250 0.209 True True unknown unknown unknown None None None None None 7ubs K k 0 D protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-26 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.250 0.209 True True unknown unknown unknown None None None None None 7uc8 H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-73 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.9 X-RAY DIFFRACTION 0.252 0.215 True True unknown unknown unknown None None None None None 7uc8 I i 0 B protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-73 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.9 X-RAY DIFFRACTION 0.252 0.215 True True unknown unknown unknown None None None None None 7uc8 J j 0 C protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-73 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.9 X-RAY DIFFRACTION 0.252 0.215 True True unknown unknown unknown None None None None None 7ucq H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-18 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.248 0.204 True True unknown unknown unknown None None None None None 7ucq I i 0 B protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-18 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.248 0.204 True True unknown unknown unknown None None None None None 7ucq J j 0 C protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-18 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.248 0.204 True True unknown unknown unknown None None None None None 7ucq K k 0 D protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1 domain in complex with 230AS-18 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.5 X-RAY DIFFRACTION 0.248 0.204 True True unknown unknown unknown None None None None None 7ufw H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1D2 in complex with LMIV230-01 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.1 X-RAY DIFFRACTION 0.213 0.190 True True unknown unknown unknown None None None None None 7ufw I i 0 B protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1D2 in complex with LMIV230-01 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 2.1 X-RAY DIFFRACTION 0.213 0.190 True True unknown unknown unknown None None None None None 7ui1 H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1D2 domain in complex with 230AL-37 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 3.3 X-RAY DIFFRACTION 0.300 0.264 True True unknown unknown unknown None None None None None 7ui1 I i 0 B protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1D2 domain in complex with 230AL-37 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 3.3 X-RAY DIFFRACTION 0.300 0.264 True True unknown unknown unknown None None None None None 7ui1 J j 0 C protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1D2 domain in complex with 230AL-37 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 3.3 X-RAY DIFFRACTION 0.300 0.264 True True unknown unknown unknown None None None None None 7ui1 K k 0 D protein NA gametocyte surface protein p230 CELL INVASION 02/15/23 Pfs230 D1D2 domain in complex with 230AL-37 Homo sapiens; Plasmodium falciparum homo sapiens plasmodium falciparum Tang, W.K., Tolia, N.H. 3.3 X-RAY DIFFRACTION 0.300 0.264 True True unknown unknown unknown None None None None None 7urv D d 0 C protein NA b-lymphocyte antigen cd19 PROTEIN BINDING 02/15/23 FMC63 scFv in complex with soluble CD19 Homo sapiens; Mus musculus mus musculus homo sapiens Meyerson, J., He, C. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7urx H L 0 C protein NA b-lymphocyte antigen cd19 PROTEIN BINDING 02/15/23 SJ25C1 Fab in complex with soluble CD19 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Meyerson, J., He, C. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7uvh A B 0 C protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by RUPA-32 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Newton, J., Julien, J.P. 2.59 X-RAY DIFFRACTION 0.233 0.196 False True IGHV3 IGKV3 Kappa None None None None None 7uvh D E 0 F protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by RUPA-32 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Newton, J., Julien, J.P. 2.59 X-RAY DIFFRACTION 0.233 0.196 False True IGHV3 IGKV3 Kappa None None None None None 7uvi A B 0 C protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by RUPA-55 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Newton, J., Julien, J.P. 2.92 X-RAY DIFFRACTION 0.237 0.218 False True IGHV3 IGKV3 Kappa None None None None None 7uvi D E 0 F protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by RUPA-55 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Newton, J., Julien, J.P. 2.92 X-RAY DIFFRACTION 0.237 0.218 False True IGHV3 IGKV3 Kappa None None None None None 7uvo A B 0 C protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by RUPA-38 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Newton, J., Julien, J.P. 2.09 X-RAY DIFFRACTION 0.235 0.217 False True IGHV3 IGLV2 Lambda None None None None None 7uvq C B 0 A protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by RUPA-97 and 15C5 Fabs Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Julien, J.P. 3.29 X-RAY DIFFRACTION 0.264 0.215 False True IGHV3 IGKV4 Kappa None None None None None 7uvq D E 0 A protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by RUPA-97 and 15C5 Fabs Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Julien, J.P. 3.29 X-RAY DIFFRACTION 0.264 0.215 False True IGHV3 IGKV3 Kappa None None None None None 7uvs A B 0 C protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by LMIV230-02 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Julien, J.P. 2.06 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV4 Kappa None None None None None 7uvs D E 0 F protein NA gametocyte surface protein p230 CELL INVASION/IMMUNE SYSTEM 02/15/23 Pfs230 domain 1 bound by LMIV230-02 Fab Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Ivanochko, D., Julien, J.P. 2.06 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV4 Kappa None None None None None 7uxl F E 0 R protein NA gametocyte surface protein p45/48 IMMUNE SYSTEM 02/15/23 Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-44 and RUPA-29 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., Ivanochko, D., Julien, J.P. 2.86 X-RAY DIFFRACTION 0.222 0.183 False True IGHV4 IGKV1 Kappa None None None None None 7uxl A B 0 R protein NA gametocyte surface protein p45/48 IMMUNE SYSTEM 02/15/23 Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-44 and RUPA-29 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., Ivanochko, D., Julien, J.P. 2.86 X-RAY DIFFRACTION 0.222 0.183 False True IGHV3 IGLV3 Lambda None None None None None 7wwi E D 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/15/23 EM structure of SARS-CoV-2 Omicron variant spike glycoprotein and 55A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wwi G F 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/15/23 EM structure of SARS-CoV-2 Omicron variant spike glycoprotein and 55A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wwi I H 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/15/23 EM structure of SARS-CoV-2 Omicron variant spike glycoprotein and 55A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wwj G F 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/15/23 EM structure of SARS-CoV-2 Omicron variant spike glycoprotein and 55A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wwj I H 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/15/23 EM structure of SARS-CoV-2 Omicron variant spike glycoprotein and 55A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wwk G F 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/15/23 EM structure of SARS-CoV-2 Omicron variant spike glycoprotein and 55A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wwk I H 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/15/23 EM structure of SARS-CoV-2 Omicron variant spike glycoprotein and 55A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Lu, Y., Yang, H., Ji, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7xv3 N NA 0 A | B protein | protein NA | NA engineered g protein subunit s (mini-gs) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/15/23 Cryo-EM structure of LPS-bound GPR174 in complex with Gs protein Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Liang, J. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8djg A B 0 F protein NA isoform 2 of adhesion g protein-coupled receptor l3 SIGNALING PROTEIN/Immune System 02/15/23 ADGRL3-lectin domain in complex with an activating synthetic antibody fragment Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Kordon, S.P., Bandekar, S.J., Arac, D. 2.65 X-RAY DIFFRACTION 0.274 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8djg C D 0 E protein NA isoform 2 of adhesion g protein-coupled receptor l3 SIGNALING PROTEIN/Immune System 02/15/23 ADGRL3-lectin domain in complex with an activating synthetic antibody fragment Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Kordon, S.P., Bandekar, S.J., Arac, D. 2.65 X-RAY DIFFRACTION 0.274 0.237 False True IGHV3 IGKV1 Kappa None None None None None 8hpj B C 0 A protein NA oxalate TRANSPORT PROTEIN/IMMUNE SYSTEM 02/15/23 Crystal structure of the bacterial oxalate transporter OxlT in a ligand-free outward-facing form Mus musculus; Oxalobacter formigenes mus musculus mus musculus oxalobacter formigenes Shimamura, T., Hirai, T., Yamashita, A. 3.3 X-RAY DIFFRACTION 0.286 0.260 False True IGHV5 IGKV6 Kappa None None None None None 8hpj E F 0 D protein NA oxalate TRANSPORT PROTEIN/IMMUNE SYSTEM 02/15/23 Crystal structure of the bacterial oxalate transporter OxlT in a ligand-free outward-facing form Mus musculus; Oxalobacter formigenes mus musculus mus musculus oxalobacter formigenes Shimamura, T., Hirai, T., Yamashita, A. 3.3 X-RAY DIFFRACTION 0.286 0.260 False True IGHV5 IGKV6 Kappa None None None None None 8hpk H L 0 A protein NA oxalate TRANSPORT PROTEIN/IMMUNE SYSTEM 02/15/23 Crystal structure of the bacterial oxalate transporter OxlT in an oxalate-bound occluded form Mus musculus; Oxalobacter formigenes mus musculus mus musculus oxalobacter formigenes Shimamura, T., Hirai, T., Yamashita, A. 3 X-RAY DIFFRACTION 0.278 0.237 False True IGHV1 IGKV4 Kappa None None None None None 7pa7 E e 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 A a 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 B b 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 C c 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 D d 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 M m 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 N n 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 O o 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 P p 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa7 Q q 0 NA NA NA NA VIRAL PROTEIN 01/08/09 BK polyomavirus VP1 in complex with scFv 29B1 Betapolyomavirus hominis; Homo sapiens Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 2.6 X-RAY DIFFRACTION 0.272 0.247 True True unknown unknown unknown None None None None None 7pa6 K k 0 A protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 L l 0 B protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 M m 0 C protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 N n 0 D protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 O o 0 E protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 P p 0 F protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 Q q 0 G protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 R r 0 H protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 S s 0 I protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7pa6 T t 0 J protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 27C11 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Nagel, F., Freytag, J., Stehle, T. 1.9 X-RAY DIFFRACTION 0.216 0.184 True True unknown unknown unknown None None None None None 7paa Z z 0 NA NA NA NA VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa K k 0 NA NA NA NA VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa A a 0 F protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa B b 0 G protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa C c 0 H protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa D d 0 I protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa E e 0 J protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa W w 0 NA NA NA NA VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa X x 0 NA NA NA NA VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7paa Y y 0 NA NA NA NA VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with scFv 29B1 Homo sapiens; JC polyomavirus Harprecht, C., Stroeh, L.J., Freytag, J., Stehle, T. 3.102 X-RAY DIFFRACTION 0.240 0.225 True True unknown unknown unknown None None None None None 7pa8 Y F 0 E protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 27C2 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 3.15 X-RAY DIFFRACTION 0.241 0.212 False False IGHV3 IGLV1 Lambda None None None None None 7pa8 H G 0 C protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 27C2 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 3.15 X-RAY DIFFRACTION 0.241 0.212 False False IGHV3 IGLV1 Lambda None None None None None 7pa8 J I 0 B protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 27C2 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 3.15 X-RAY DIFFRACTION 0.241 0.212 False False IGHV3 IGLV1 Lambda None None None None None 7pa8 L K 0 A protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 27C2 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 3.15 X-RAY DIFFRACTION 0.241 0.212 False False IGHV3 IGLV1 Lambda None None None None None 7pa8 N M 0 D protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 27C2 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 3.15 X-RAY DIFFRACTION 0.241 0.212 False False IGHV3 IGLV1 Lambda None None None None None 7pa9 K L 0 D protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 M N 0 A protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 O P 0 B protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 Q R 0 E protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 T S 0 I protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 X U 0 G protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 V W 0 J protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 Y Z 0 F protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 b a 0 H protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7pa9 c d 0 C protein NA unknown VIRAL PROTEIN 01/08/09 JC polyomavirus VP1 in complex with Fab 98D3 Homo sapiens; JC polyomavirus Stroeh, L.J., Harprecht, C., Freytag, J., Stehle, T. 2.75 X-RAY DIFFRACTION 0.263 0.207 False False IGHV3 IGKV1 Kappa None None None None None 7uhz H L 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 01/08/09 Post-fusion ectodomain of HSV-1 gB in complex with BMPC-23 Fab Human alphaherpesvirus 1 strain KOS; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 strain kos Windsor, I.W., Kong, S.L., Garforth, S.J., Almo, S.C., Harrison, S.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uhz I M 0 B protein NA envelope glycoprotein b VIRAL PROTEIN 01/08/09 Post-fusion ectodomain of HSV-1 gB in complex with BMPC-23 Fab Human alphaherpesvirus 1 strain KOS; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 strain kos Windsor, I.W., Kong, S.L., Garforth, S.J., Almo, S.C., Harrison, S.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uhz J N 0 C protein NA envelope glycoprotein b VIRAL PROTEIN 01/08/09 Post-fusion ectodomain of HSV-1 gB in complex with BMPC-23 Fab Human alphaherpesvirus 1 strain KOS; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 strain kos Windsor, I.W., Kong, S.L., Garforth, S.J., Almo, S.C., Harrison, S.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7ui0 H L 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/Immune System 01/08/09 Post-fusion ectodomain of HSV-1 gB in complex with HSV010-13 Fab Human alphaherpesvirus 1 strain KOS; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 strain kos Windsor, I.W., Kong, S.L., Garforth, S.J., Almo, S.C., Harrison, S.C. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 7ui0 I M 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/Immune System 01/08/09 Post-fusion ectodomain of HSV-1 gB in complex with HSV010-13 Fab Human alphaherpesvirus 1 strain KOS; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 strain kos Windsor, I.W., Kong, S.L., Garforth, S.J., Almo, S.C., Harrison, S.C. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 7ui0 J N 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/Immune System 01/08/09 Post-fusion ectodomain of HSV-1 gB in complex with HSV010-13 Fab Human alphaherpesvirus 1 strain KOS; Mus musculus mus musculus mus musculus human alphaherpesvirus 1 strain kos Windsor, I.W., Kong, S.L., Garforth, S.J., Almo, S.C., Harrison, S.C. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 7yue A a 0 C peptide NA spike protein s2 ANTIVIRAL PROTEIN 02/08/23 Epitope-directed anti-SARS CoV 2 scFv engineered against the key spike protein region. Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens severe acute respiratory syndrome coronavirus2 Kumar, U., Jaiswal, D., Gaur, V., Salunke, D.M. 2.35 X-RAY DIFFRACTION 0.232 0.179 True True unknown unknown unknown None None None None None 7z2m B A 0 K protein NA interleukin-17a IMMUNE SYSTEM 02/08/23 Crystal Structure of the 11.003 Fab in complex with human IL-17A Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 1.899 X-RAY DIFFRACTION 0.227 0.201 False True IGHV5 IGKV3 Kappa None None None None None 7z2m D C 0 G protein NA interleukin-17a IMMUNE SYSTEM 02/08/23 Crystal Structure of the 11.003 Fab in complex with human IL-17A Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 1.899 X-RAY DIFFRACTION 0.227 0.201 False True IGHV5 IGKV3 Kappa None None None None None 7z2m F E 0 J protein NA interleukin-17a IMMUNE SYSTEM 02/08/23 Crystal Structure of the 11.003 Fab in complex with human IL-17A Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 1.899 X-RAY DIFFRACTION 0.227 0.201 False True IGHV5 IGKV3 Kappa None None None None None 7z2m H L 0 I protein NA interleukin-17a IMMUNE SYSTEM 02/08/23 Crystal Structure of the 11.003 Fab in complex with human IL-17A Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 1.899 X-RAY DIFFRACTION 0.227 0.201 False True IGHV5 IGKV3 Kappa None None None None None 7z3w H L 0 H Hapten ETE 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL IMMUNE SYSTEM 02/08/23 Crystal structure of the AAL160 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 2 X-RAY DIFFRACTION 0.218 0.196 False True IGHV5 IGKV3 Kappa None None None None None 7z4t H L 0 I protein NA interleukin-1 beta IMMUNE SYSTEM 02/08/23 AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA Homo sapiens homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 3.3 X-RAY DIFFRACTION 0.269 0.238 False True IGHV5 IGKV3 Kappa None None None None None 8dqu A NA 0 C protein NA non-structural protein 9 VIRAL PROTEIN 02/08/23 Nanobody bound SARS-CoV-2 Nsp9 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Littler, D.R., Gully, B.S., Rossjohn, J. 2.45003 X-RAY DIFFRACTION 0.229 0.203 False True IGHV1 NA NA None None None None None 8dqu B NA 0 F protein NA non-structural protein 9 VIRAL PROTEIN 02/08/23 Nanobody bound SARS-CoV-2 Nsp9 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Littler, D.R., Gully, B.S., Rossjohn, J. 2.45003 X-RAY DIFFRACTION 0.229 0.203 False True IGHV1 NA NA None None None None None 8f6e D C 0 A protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded wild-type YiiP-Fab complex Homo sapiens; Shewanella oneidensis homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6e F E 0 B protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded wild-type YiiP-Fab complex Homo sapiens; Shewanella oneidensis homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6f D C 0 A protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded D51A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6f F E 0 B protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded D51A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6h D C 0 A protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded asymmetrical TMD D70A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis MR-1 homo sapiens homo sapiens shewanella oneidensis mr-1 Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6h F E 0 B protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded asymmetrical TMD D70A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis MR-1 homo sapiens homo sapiens shewanella oneidensis mr-1 Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6i F E 0 B protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded symmetrical D70A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis MR-1 homo sapiens homo sapiens shewanella oneidensis mr-1 Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6i D C 0 A protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded symmetrical D70A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis MR-1 homo sapiens homo sapiens shewanella oneidensis mr-1 Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6j F E 0 B protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded D287A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8f6j D C 0 A protein NA cadmium and zinc efflux pump fief TRANSPORT PROTEIN 02/08/23 Cryo-EM structure of a Zinc-loaded D287A mutant of the YiiP-Fab complex Homo sapiens; Shewanella oneidensis homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Hussein, A.K., Stokes, D.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8h3x A NA 0 C protein NA fragilysin TOXIN 02/08/23 Bacteroide Fragilis Toxin in complex with nanobody 282 Bacteroides fragilis; Vicugna pacos vicugna pacos bacteroides fragilis Wen, Y., Guo, Y. 1.66 X-RAY DIFFRACTION 0.216 0.183 False True IGHV3 NA NA None None None None None 8h3y D NA 0 B protein NA fragilysin TOXIN 02/08/23 Bacteroide Fragilis Toxin in complex with nanobody 327 Bacteroides fragilis; Vicugna pacos vicugna pacos bacteroides fragilis Wen, Y., Guo, Y. 2.25 X-RAY DIFFRACTION 0.244 0.204 False True IGHV1 NA NA None None None None None 8h3y E NA 0 C protein NA fragilysin TOXIN 02/08/23 Bacteroide Fragilis Toxin in complex with nanobody 327 Bacteroides fragilis; Vicugna pacos vicugna pacos bacteroides fragilis Wen, Y., Guo, Y. 2.25 X-RAY DIFFRACTION 0.244 0.204 False True IGHV1 NA NA None None None None None 8h3y F NA 0 A protein NA fragilysin TOXIN 02/08/23 Bacteroide Fragilis Toxin in complex with nanobody 327 Bacteroides fragilis; Vicugna pacos vicugna pacos bacteroides fragilis Wen, Y., Guo, Y. 2.25 X-RAY DIFFRACTION 0.244 0.204 False True IGHV1 NA NA None None None None None 8h8j H h 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein subunit alpha-13 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/08/23 Lodoxamide-bound GPR35 in complex with G13 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Yuan, Q., Duan, J., Liu, Q., Xu, H.E., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7qvk B NA 0 A protein NA unknown ONCOPROTEIN 01/08/09 NM-02 in complex with HER2-ECD Camelus bactrianus; Homo sapiens Cowan, R., Hall, G., Carr, M. 3.1 X-RAY DIFFRACTION 0.330 0.275 False False IGHV1 NA NA None None None None None 7ued H L 0 NA NA NA NA IMMUNE SYSTEM 02/01/23 Crystal structure of full length mesothelin bound with MORAb-009 Fab Homo sapiens; Mus musculus mus musculus mus musculus Zhan, J., Esser, L., Lin, D., Tang, W.K., Xia, D. 3 X-RAY DIFFRACTION 0.237 0.201 False True IGHV1 IGKV4 Kappa None None None None None 7wn0 B NA 0 A protein NA equilibrative nucleoside/nucleobase transporter TRANSPORT PROTEIN 02/01/23 Structure of PfENT1(Y190A) in complex with nanobody 19 Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Wang, C., Deng, D., Ren, R.B., Yu, L.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7wn1 C NA 0 A protein NA equilibrative nucleoside/nucleobase transporter TRANSPORT PROTEIN 02/01/23 Structure of PfNT1(Y190A) in complex with nanobody 48 and inosine Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Wang, C., Deng, D., Ren, R.B., Yu, L.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7wr9 A B 0 F protein NA spike protein s1 VIRAL PROTEIN 02/01/23 Local CryoEM structure of the SARS-CoV S2P in complex with BD55-3152 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 7x8p C B 0 A protein NA frizzled-2 SIGNALING PROTEIN 02/01/23 Frizzled 2 CRD in complex with pF7_A5 Fab Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Ge, Q., Wang, Q. 2.24 X-RAY DIFFRACTION 0.241 0.216 False True IGHV3 IGLV3 Lambda None None None None None 7x8p F E 0 D protein NA frizzled-2 SIGNALING PROTEIN 02/01/23 Frizzled 2 CRD in complex with pF7_A5 Fab Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Ge, Q., Wang, Q. 2.24 X-RAY DIFFRACTION 0.241 0.216 False True IGHV3 IGLV3 Lambda None None None None None 7x8t C B 0 A protein NA frizzled-10 SIGNALING PROTEIN 02/01/23 Frizzled 10 CRD in complex with hB9L9.3 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ge, Q., Wang, Q. 2.51 X-RAY DIFFRACTION 0.215 0.176 False True IGHV3 IGLV3 Lambda None None None None None 7x8t F E 0 D protein NA frizzled-10 SIGNALING PROTEIN 02/01/23 Frizzled 10 CRD in complex with hB9L9.3 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ge, Q., Wang, Q. 2.51 X-RAY DIFFRACTION 0.215 0.176 False True IGHV3 IGLV3 Lambda None None None None None 7x8t I H 0 G protein NA frizzled-10 SIGNALING PROTEIN 02/01/23 Frizzled 10 CRD in complex with hB9L9.3 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ge, Q., Wang, Q. 2.51 X-RAY DIFFRACTION 0.215 0.176 False True IGHV3 IGLV3 Lambda None None None None None 7x8t L K 0 J protein NA frizzled-10 SIGNALING PROTEIN 02/01/23 Frizzled 10 CRD in complex with hB9L9.3 Fab Homo sapiens homo sapiens homo sapiens homo sapiens Ge, Q., Wang, Q. 2.51 X-RAY DIFFRACTION 0.215 0.176 False True IGHV3 IGLV3 Lambda None None None None None 7yck C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with FP-12A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Nguyen, V.H.T., Chen, X. 2.6 X-RAY DIFFRACTION 0.264 0.229 False True IGHV3 IGLV6 Lambda None None None None None 7yck E F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with FP-12A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Nguyen, V.H.T., Chen, X. 2.6 X-RAY DIFFRACTION 0.264 0.229 False True IGHV3 IGLV6 Lambda None None None None None 7ycl A B 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with IS-9A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 2.13 X-RAY DIFFRACTION 0.218 0.174 False True IGHV5 IGKV1 Kappa None None None None None 7ycl H L 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with IS-9A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 2.13 X-RAY DIFFRACTION 0.218 0.174 False True IGHV5 IGKV1 Kappa None None None None None 7ycn K L 0 J protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with IY-2A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 2.85 X-RAY DIFFRACTION 0.250 0.211 False True IGHV4 IGLV6 Lambda None None None None None 7ycn E F 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with IY-2A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 2.85 X-RAY DIFFRACTION 0.250 0.211 False True IGHV4 IGLV6 Lambda None None None None None 7ycn C D 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with IY-2A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 2.85 X-RAY DIFFRACTION 0.250 0.211 False True IGHV4 IGLV6 Lambda None None None None None 7ycn H I 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 Crystal structure of SARS-CoV-2 Spike RBD in complex with IY-2A Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Chen, X. 2.85 X-RAY DIFFRACTION 0.250 0.211 False True IGHV4 IGLV6 Lambda None None None None None 7yzj H L 0 E peptide NA antigenic peptide PEPTIDE BINDING PROTEIN 02/01/23 FAB IN COMPLEX WITH ANTIGENIC PEPTIDE OF INTERLEUKIN-2 Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Pletnev, V., Pletneva, N. 2.6 X-RAY DIFFRACTION 0.241 0.158 False False IGHV3 IGKV1 Kappa None None None None None 8d0a H L 0 A protein NA ubiquitin carboxyl-terminal hydrolase 30 HYDROLASE 02/01/23 Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Song, X., Butler, J., Li, C., Zhang, K., Zhang, D., Hao, Y. 3.19 X-RAY DIFFRACTION 0.291 0.243 False True IGHV14 IGKV6 Kappa None None None None None 8d1t H L 0 A protein NA ubiquitin carboxyl-terminal hydrolase 30 HYDROLASE 02/01/23 Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Song, X., Butler, J., Li, C., Zhang, K., Zhang, D., Hao, Y. 2.94 X-RAY DIFFRACTION 0.294 0.236 False True IGHV14 IGKV6 Kappa None None None None None 8dtn A NA 0 B peptide NA b-cell lymphoma/leukemia 11a DNA BINDING PROTEIN 02/01/23 The complex of nanobody 6101 with BCL11A ZF6 Homo sapiens; Lama glama lama glama homo sapiens Yin, M., Tenglin, K., Zhai, L., Dassama, L.M., Orkin, S.H. 2.199 X-RAY DIFFRACTION 0.232 0.195 False True IGHV1 NA NA None None None None None 8dtn C NA 0 D peptide NA b-cell lymphoma/leukemia 11a DNA BINDING PROTEIN 02/01/23 The complex of nanobody 6101 with BCL11A ZF6 Homo sapiens; Lama glama lama glama homo sapiens Yin, M., Tenglin, K., Zhai, L., Dassama, L.M., Orkin, S.H. 2.199 X-RAY DIFFRACTION 0.232 0.195 False True IGHV1 NA NA None None None None None 8dtn E NA 0 F peptide NA b-cell lymphoma/leukemia 11a DNA BINDING PROTEIN 02/01/23 The complex of nanobody 6101 with BCL11A ZF6 Homo sapiens; Lama glama lama glama homo sapiens Yin, M., Tenglin, K., Zhai, L., Dassama, L.M., Orkin, S.H. 2.199 X-RAY DIFFRACTION 0.232 0.195 False True IGHV1 NA NA None None None None None 8dtn G NA 0 H peptide NA b-cell lymphoma/leukemia 11a DNA BINDING PROTEIN 02/01/23 The complex of nanobody 6101 with BCL11A ZF6 Homo sapiens; Lama glama lama glama homo sapiens Yin, M., Tenglin, K., Zhai, L., Dassama, L.M., Orkin, S.H. 2.199 X-RAY DIFFRACTION 0.232 0.195 False True IGHV1 NA NA None None None None None 8dtu A NA 0 C | B peptide | peptide NA | NA b-cell lymphoma/leukemia 11a | nanobody 5344n74d DNA BINDING PROTEIN 02/01/23 The complex of nanobody 5344N74D with BCL11A ZF6. Homo sapiens; Lama glama lama glama homo sapiens | lama glama Yin, M., Tenglin, K., Zhai, L., Dassama, L.M., Orkin, S.H. 2.447 X-RAY DIFFRACTION 0.288 0.261 False True IGHV1 NA NA None None None None None 8fe3 H L 0 B protein NA prm protein VIRUS/IMMUNE SYSTEM 02/01/23 Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody Dengue virus type 2; Mus musculus mus musculus mus musculus dengue virus type 2 Dowd, A.D., Sirohi, D., Speer, S., Mukherjee, S., Govero, J., Aleshnick, M., Larman, B., Sukupolvi-Petty, S., Sevvana, M., Miller, A.S., Klose, T., Zheng, A., Kielian, M., Kuhn, R.J., Diamond, M.S., Pierson, T.C. 10.2 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV1 IGKV3 Kappa None None None None None 8fe3 M N 0 D protein NA prm protein VIRUS/IMMUNE SYSTEM 02/01/23 Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody Dengue virus type 2; Mus musculus mus musculus mus musculus dengue virus type 2 Dowd, A.D., Sirohi, D., Speer, S., Mukherjee, S., Govero, J., Aleshnick, M., Larman, B., Sukupolvi-Petty, S., Sevvana, M., Miller, A.S., Klose, T., Zheng, A., Kielian, M., Kuhn, R.J., Diamond, M.S., Pierson, T.C. 10.2 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV1 IGKV3 Kappa None None None None None 8fe3 O P 0 F protein NA prm protein VIRUS/IMMUNE SYSTEM 02/01/23 Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody Dengue virus type 2; Mus musculus mus musculus mus musculus dengue virus type 2 Dowd, A.D., Sirohi, D., Speer, S., Mukherjee, S., Govero, J., Aleshnick, M., Larman, B., Sukupolvi-Petty, S., Sevvana, M., Miller, A.S., Klose, T., Zheng, A., Kielian, M., Kuhn, R.J., Diamond, M.S., Pierson, T.C. 10.2 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV1 IGKV3 Kappa None None None None None 8fe4 H L 0 B protein NA prm protein VIRUS/IMMUNE SYSTEM 02/01/23 Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody Dengue virus type 2; Mus musculus mus musculus mus musculus dengue virus type 2 Dowd, A.D., Sirohi, D., Speer, S., Mukherjee, S., Govero, J., Aleshnick, M., Larman, B., Sukupolvi-Petty, S., Sevvana, M., Miller, A.S., Klose, T., Zheng, A., Kielian, M., Kuhn, R.J., Diamond, M.S., Pierson, T.C. 9.8 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV1 IGKV4 Kappa None None None None None 8fe4 M N 0 D protein NA prm protein VIRUS/IMMUNE SYSTEM 02/01/23 Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody Dengue virus type 2; Mus musculus mus musculus mus musculus dengue virus type 2 Dowd, A.D., Sirohi, D., Speer, S., Mukherjee, S., Govero, J., Aleshnick, M., Larman, B., Sukupolvi-Petty, S., Sevvana, M., Miller, A.S., Klose, T., Zheng, A., Kielian, M., Kuhn, R.J., Diamond, M.S., Pierson, T.C. 9.8 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV1 IGKV4 Kappa None None None None None 8fe4 O P 0 F protein NA prm protein VIRUS/IMMUNE SYSTEM 02/01/23 Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody Dengue virus type 2; Mus musculus mus musculus mus musculus dengue virus type 2 Dowd, A.D., Sirohi, D., Speer, S., Mukherjee, S., Govero, J., Aleshnick, M., Larman, B., Sukupolvi-Petty, S., Sevvana, M., Miller, A.S., Klose, T., Zheng, A., Kielian, M., Kuhn, R.J., Diamond, M.S., Pierson, T.C. 9.8 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV1 IGKV4 Kappa None None None None None 8hhx F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with FP-12A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8hhx H NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with FP-12A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8hhx NA I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with FP-12A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True NA IGLV6 Lambda None None None None None 8hhy H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with IS-9A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 8hhy F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with IS-9A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 NA NA None None None None None 8hhy NA W 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with IS-9A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 8hhy G NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with IS-9A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 NA NA None None None None None 8hhy NA I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Delta Spike in complex with IS-9A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 8hhz E F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Omicron BA.1 Spike in complex with IY-2A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8hhz G H 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Omicron BA.1 Spike in complex with IY-2A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8hhz I J 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/01/23 SARS-CoV-2 Omicron BA.1 Spike in complex with IY-2A Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Mohapatra, A., Wu, Y.-M. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 8hit A B 0 C protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 02/01/23 Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Tan, S., Shi, Y., Wang, Q., Gao, G.F., Guan, J., Chai, Y., Qi, J. 3.2 X-RAY DIFFRACTION 0.298 0.251 False True IGHV4 IGKV1 Kappa None None None None None 7ts0 H h 0 A | B protein | protein NA | NA dominant negative go alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/09/22 Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhao, L.-H., Lin, J., Mao, C., Zhou, X.E., Ji, S., Shen, D., Xiao, P., Melcher, K., Zhang, Y., Yu, X., Xu, H.E. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7tn9 A B 0 U protein NA envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 7tn9 Q R 0 V protein NA gp2 IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7tn9 M N 0 W | X protein | protein NA | NA gp2 | gp2 IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 | ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7tn9 E F 0 S protein NA envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 7tn9 G H 0 T protein NA envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7tn9 O P 0 V protein NA gp2 IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7tn9 I J 0 U protein NA envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7tn9 C D 0 T protein NA envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/25/23 Structure of the Inmazeb cocktail and resistance to escape against Ebola virus Ebola virus - Mayinga, Zaire, 1976; Mus musculus mus musculus mus musculus ebola virus - mayinga, zaire, 1976 Rayaprolu, V., Fulton, B., Rafique, A., Arturo, E., Williams, D., Hariharan, C., Callaway, H., Parvate, A., Schendel, S.L., Parekh, D., Hui, S., Shaffer, K., Pascal, K.E., Wloga, E., Giordano, S., Copin, R., Franklin, M., Boytz, R.M., Donahue, C., Davey, R., Baum, A., Kyratsous, C.A., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 7yxu H L 0 A protein NA tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 01/25/23 Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB. Homo sapiens homo sapiens homo sapiens homo sapiens Hakansson, M., Rose, N., Petersson, J., Enell Smith, K., Thorolfsson, M., von Schantz, L. 2.31 X-RAY DIFFRACTION 0.252 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8de6 E F 0 A | C protein | protein NA | NA complement component c9 | complement component c9 IMMUNE SYSTEM 01/08/09 Oligomeric C9 in complex with aE11 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens | homo sapiens Bayly-Jones, C. 0 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV10 Kappa None None None None None 8de6 B I 0 G protein NA complement component c9 IMMUNE SYSTEM 01/08/09 Oligomeric C9 in complex with aE11 Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Bayly-Jones, C. 0 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV10 Kappa None None None None None 7t5o H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 VFLIP Spike Trimer with GAR03 Homo sapiens; Severe acute respiratory syndrome-related coronavirus homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Sobti, M., Stewart, A.G., Rouet, R., Langley, D.B. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 7t8x E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/25/23 Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, J., Wang, Q., Du, Y., Kobilka, B.K. 3.21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7t90 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/25/23 Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, J., Wang, Q., Du, Y., Kobilka, B.K. 3.32 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7t94 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/25/23 Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, J., Wang, Q., Du, Y., Kobilka, B.K. 3.16 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7t96 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/25/23 Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, J., Wang, Q., Du, Y., Kobilka, B.K. 3.22 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wn8 H L 0 A protein NA leukocyte surface antigen cd47 ANTITUMOR PROTEIN 01/25/23 Crystal structure of antibody (BC31M5) binds to CD47 Homo sapiens homo sapiens homo sapiens homo sapiens Li, Y., Wang, W., Sui, J., Zhang, S. 2.8 X-RAY DIFFRACTION 0.276 0.243 False True IGHV1 IGKV3 Kappa None None None None None 7wn8 P Q 0 C protein NA leukocyte surface antigen cd47 ANTITUMOR PROTEIN 01/25/23 Crystal structure of antibody (BC31M5) binds to CD47 Homo sapiens homo sapiens homo sapiens homo sapiens Li, Y., Wang, W., Sui, J., Zhang, S. 2.8 X-RAY DIFFRACTION 0.276 0.243 False True IGHV1 IGKV3 Kappa None None None None None 7wqv B b 0 A protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 7wqv D d 0 C protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 7wqv F f 0 E protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 7wqv H h 0 G protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 7wqv J j 0 I protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 7wqv L l 0 K protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 7wqv N n 0 M protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 7wqv P p 0 O protein NA spike protein s1 VIRAL PROTEIN 01/25/23 Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zha, J., Meng, L., Zhang, X., Li, D. 2.8 X-RAY DIFFRACTION 0.251 0.220 True True unknown unknown unknown None None None None None 8be1 A B 0 C protein NA spike protein s1 IMMUNE SYSTEM 01/25/23 SARS-CoV-2 RBD in complex with a Fab fragment of a neutralising antibody mRBD2 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Lulla, A., Brear, P., Fischer, K., Hollfelder, F., Hyvonen, M. 1.98 X-RAY DIFFRACTION 0.284 0.248 False True IGHV1 IGKV9 Kappa None None None None None 8be1 D E 0 F protein NA spike protein s1 IMMUNE SYSTEM 01/25/23 SARS-CoV-2 RBD in complex with a Fab fragment of a neutralising antibody mRBD2 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Lulla, A., Brear, P., Fischer, K., Hollfelder, F., Hyvonen, M. 1.98 X-RAY DIFFRACTION 0.284 0.248 False True IGHV1 IGKV9 Kappa None None None None None 8d48 H L 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN 01/25/23 sd1.040 Fab in complex with SARS-CoV-2 Spike 2P glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Abernathy, M.E., Barnes, C.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 8db4 A B 0 E protein NA ara h 2 allergen ALLERGEN/IMMUNE SYSTEM 01/25/23 Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Min, J., Pedersen, L.C. 2.3 X-RAY DIFFRACTION 0.246 0.211 False True IGHV3 IGKV3 Kappa None None None None None 8db4 C D 0 E protein NA ara h 2 allergen ALLERGEN/IMMUNE SYSTEM 01/25/23 Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Min, J., Pedersen, L.C. 2.3 X-RAY DIFFRACTION 0.246 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8db4 G H 0 F protein NA ara h 2 allergen ALLERGEN/IMMUNE SYSTEM 01/25/23 Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Min, J., Pedersen, L.C. 2.3 X-RAY DIFFRACTION 0.246 0.211 False True IGHV3 IGKV3 Kappa None None None None None 8db4 I J 0 F protein NA ara h 2 allergen ALLERGEN/IMMUNE SYSTEM 01/25/23 Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1 Arachis hypogaea; Homo sapiens homo sapiens homo sapiens arachis hypogaea Min, J., Pedersen, L.C. 2.3 X-RAY DIFFRACTION 0.246 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8dgu H L 0 A peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC25.106 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 1.89 X-RAY DIFFRACTION 0.245 0.214 False True IGHV1 IGLV1 Lambda None None None None None 8dgv H L 0 A peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC99.103 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus (isolate united kingdom/h123990006/2012) Liu, H., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.249 0.203 False True IGHV1 IGKV3 Kappa None None None None None 8dgw H L 0 G peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of HCoV-HKU1 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC95.108 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human coronavirus hku1 (isolate n1) Liu, H., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.248 0.217 False True IGHV1 IGLV1 Lambda None None None None None 8dgw A B 0 I peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of HCoV-HKU1 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC95.108 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human coronavirus hku1 (isolate n1) Liu, H., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.248 0.217 False True IGHV1 IGLV1 Lambda None None None None None 8dgw C D 0 J peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of HCoV-HKU1 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC95.108 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human coronavirus hku1 (isolate n1) Liu, H., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.248 0.217 False True IGHV1 IGLV1 Lambda None None None None None 8dgw E F 0 K peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of HCoV-HKU1 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC95.108 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human coronavirus hku1 (isolate n1) Liu, H., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.248 0.217 False True IGHV1 IGLV1 Lambda None None None None None 8dgx H L 0 C peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC68.109 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus (isolate united kingdom/h123990006/2012) Liu, H., Wilson, I.A. 2.89 X-RAY DIFFRACTION 0.280 0.233 False True IGHV1 IGKV3 Kappa None None None None None 8dgx A B 0 D peptide NA spike protein s2' IMMUNE SYSTEM 01/25/23 Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC68.109 isolated from a vaccinated COVID-19 convalescent Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus (isolate united kingdom/h123990006/2012) Liu, H., Wilson, I.A. 2.89 X-RAY DIFFRACTION 0.280 0.233 False True IGHV1 IGKV3 Kappa None None None None None 8dl6 D C 0 A protein NA solute carrier family 40 member 1 MEMBRANE PROTEIN 01/25/23 Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Shen, J., Wilbon, A.S., Pan, Y., Zhou, M. 0 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 8dm3 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with Fab 4A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Saville, J.W., Mannar, D., Berezuk, A.M., Cholak, S., Tuttle, K.S., Vahdatihassani, F., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8dm3 M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with Fab 4A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Saville, J.W., Mannar, D., Berezuk, A.M., Cholak, S., Tuttle, K.S., Vahdatihassani, F., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8dm3 P Q 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with Fab 4A8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Saville, J.W., Mannar, D., Berezuk, A.M., Cholak, S., Tuttle, K.S., Vahdatihassani, F., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8dm4 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with Fab 4A8 (focused refinement of NTD and 4A8) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Saville, J.W., Mannar, D., Berezuk, A.M., Cholak, S., Tuttle, K.S., Vahdatihassani, F., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8ek6 H L 0 NA NA NA NA IMMUNE SYSTEM 01/25/23 UCA Y35N (unbound) Fab from CH65-CH67 lineage Homo sapiens homo sapiens homo sapiens Maurer, D.P., Schmidt, A.G. 1.954 X-RAY DIFFRACTION 0.216 0.185 False True IGHV1 IGLV3 Lambda None None None None None 8ekh H L 0 NA NA NA NA IMMUNE SYSTEM 01/25/23 I-2 Y35N H35N (unbound) Fab from CH65-CH67 lineage Homo sapiens homo sapiens homo sapiens Maurer, D.P., Schmidt, A.G. 2.7 X-RAY DIFFRACTION 0.283 0.245 False True IGHV1 IGLV3 Lambda None None None None None 8epa H L 0 I protein NA cytokine receptor common subunit gamma IMMUNE SYSTEM 01/25/23 Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Franklin, M.C., Romero Hernandez, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8epa A B 0 I protein NA cytokine receptor common subunit gamma IMMUNE SYSTEM 01/25/23 Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Franklin, M.C., Romero Hernandez, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc2 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 1 YB9-258 Fab (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc3 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 2 YB9-258 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc3 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 2 YB9-258 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc4 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype spike trimer (6P) in complex with 3 YB9-258 Fabs and 3 R1-32 Fabs (3 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8hc4 F J 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype spike trimer (6P) in complex with 3 YB9-258 Fabs and 3 R1-32 Fabs (3 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc4 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype spike trimer (6P) in complex with 3 YB9-258 Fabs and 3 R1-32 Fabs (3 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc4 K M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype spike trimer (6P) in complex with 3 YB9-258 Fabs and 3 R1-32 Fabs (3 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8hc4 G I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype spike trimer (6P) in complex with 3 YB9-258 Fabs and 3 R1-32 Fabs (3 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc4 N O 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype spike trimer (6P) in complex with 3 YB9-258 Fabs and 3 R1-32 Fabs (3 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8hc5 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype S1 in complex with YB9-258 Fab and R1-32 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc5 D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 wildtype S1 in complex with YB9-258 Fab and R1-32 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8hc6 H L 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with YB9-258 Fab, focused refinement of Fab region Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc7 H L 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) complex with YB9-258 Fab, focused refinement of RBD-dimer region Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hc8 H L 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with YB13-292 Fab, focused refinement of Fab region Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hc9 D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (3 RBD down) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hc9 F G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (3 RBD down) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hc9 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (3 RBD down) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hca D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hca F G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hca H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (1 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hcb D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hcb F G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 8hcb H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/23 SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (2 RBD up) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Chen, Q., Li, Z., Su, M., He, J., Xiong, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7wvd G H 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRUS 01/18/23 Crystal structure of H14 complexed with SIA28 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Chen, Y., Qi, J., Gao, G.F. 3.39 X-RAY DIFFRACTION 0.261 0.221 False True IGHV3 IGKV1 Kappa None None None None None 7wvd I J 0 F | A | E protein | protein | protein NA | NA | NA hemagglutinin | hemagglutinin | hemagglutinin VIRUS 01/18/23 Crystal structure of H14 complexed with SIA28 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus | influenza a virus Chen, Y., Qi, J., Gao, G.F. 3.39 X-RAY DIFFRACTION 0.261 0.221 False True IGHV3 IGKV1 Kappa None None None None None 7ucx H L 0 B peptide NA cyclized cr1 peptide TRANSPORT PROTEIN 01/18/23 LRP8 11H1 Fab complexed to a cyclized CR1 peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Argiriadi, M.A., Deng, K., Egan, D., Gao, L., Gizatullin, F., Harlan, J., Karaoglu, D., Qiu, W., Goodearl, A. 1.72 X-RAY DIFFRACTION 0.240 0.205 False True IGHV5 IGKV1 Kappa None None None None None 7wh8 B A 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/18/23 SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (focused refinement on Fab-RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7whb D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/18/23 SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Ge, J.W., Wang, X.Q. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7whb G H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/18/23 SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Ge, J.W., Wang, X.Q. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7whb J K 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/18/23 SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Ge, J.W., Wang, X.Q. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7whd D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/18/23 SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Wang, X.W., Ge, J.W., Wang, Z.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7whd G H 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/18/23 SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Wang, X.W., Ge, J.W., Wang, Z.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7whd J K 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/18/23 SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Wang, X.W., Ge, J.W., Wang, Z.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wvg C D 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRUS 01/18/23 Crystal structure of H18 complexed with SIA28 Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus | influenza a virus Chen, Y., Qi, J., Gao, G.F. 2.6 X-RAY DIFFRACTION 0.224 0.212 False True IGHV3 IGKV1 Kappa None None None None None 7wvi A B 0 NA NA NA NA VIRUS with monoclonal antibody 01/18/23 Crystal structure of SIA28 Homo sapiens homo sapiens homo sapiens Chen, Y., Qi, J., Gao, G.F. 2.48 X-RAY DIFFRACTION 0.230 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7wvi C D 0 NA NA NA NA VIRUS with monoclonal antibody 01/18/23 Crystal structure of SIA28 Homo sapiens homo sapiens homo sapiens Chen, Y., Qi, J., Gao, G.F. 2.48 X-RAY DIFFRACTION 0.230 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7x25 A C 0 G protein NA spike glycoprotein VIRAL PROTEIN 01/18/23 MERS-CoV spike complex with S41 neutralizing antibody Fab Class4 (2u1d RBD with 3Fab) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x25 E F 0 J protein NA spike glycoprotein VIRAL PROTEIN 01/18/23 MERS-CoV spike complex with S41 neutralizing antibody Fab Class4 (2u1d RBD with 3Fab) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x25 H K 0 I protein NA spike glycoprotein VIRAL PROTEIN 01/18/23 MERS-CoV spike complex with S41 neutralizing antibody Fab Class4 (2u1d RBD with 3Fab) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x28 C D 0 F protein NA spike glycoprotein VIRAL PROTEIN 01/18/23 MERS-CoV spike complex with S41 neutralizing antibody Fab Class3 (2u1d RBD with 2Fab) Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x28 H K 0 G protein NA spike glycoprotein VIRAL PROTEIN 01/18/23 MERS-CoV spike complex with S41 neutralizing antibody Fab Class3 (2u1d RBD with 2Fab) Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x8q C B 0 A protein NA frizzled-10 SIGNALING PROTEIN 01/18/23 Frizzled-10 CRD in complex with F10_A9 Fab Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Ge, Q., Wang, Q. 2.65 X-RAY DIFFRACTION 0.247 0.205 False True IGHV3 IGKV1 Kappa None None None None None 7x8q F E 0 D protein NA frizzled-10 SIGNALING PROTEIN 01/18/23 Frizzled-10 CRD in complex with F10_A9 Fab Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Ge, Q., Wang, Q. 2.65 X-RAY DIFFRACTION 0.247 0.205 False True IGHV3 IGKV1 Kappa None None None None None 8dxt H L 0 R protein NA spike protein s1 ANTIVIRAL PROTEIN 01/18/23 Fab arm of antibody GAR12 bound to the receptor binding domain of SARS-CoV-2. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D., Henry, J.Y. 2.25 X-RAY DIFFRACTION 0.254 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8dxu H L 0 R protein NA spike protein s1 ANTIVIRAL PROTEIN 01/18/23 Fab arms of antibodies GAR03 and 10G4 bound to the receptor binding domain of SARS-CoV-2 in a 1:1:1 complex. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.728 X-RAY DIFFRACTION 0.269 0.223 False True IGHV3 IGKV1 Kappa None None None None None 8dxu A B 0 R protein NA spike protein s1 ANTIVIRAL PROTEIN 01/18/23 Fab arms of antibodies GAR03 and 10G4 bound to the receptor binding domain of SARS-CoV-2 in a 1:1:1 complex. Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.728 X-RAY DIFFRACTION 0.269 0.223 False True IGHV1 IGLV3 Lambda None None None None None 8e0e B NA 0 A protein NA voltage-dependent l-type calcium channel subunit beta-2 TRANSPORT PROTEIN/IMMUNE SYSTEM 01/18/23 nbF3:CaV beta subunit 2a complex Lama glama; Rattus norvegicus lama glama rattus norvegicus Nirwan, N., Minor, D.L. 2 X-RAY DIFFRACTION 0.221 0.197 False True IGHV1 NA NA None None None None None 8fbw C D 0 E peptide NA siv v2 peptide IMMUNE SYSTEM/VIRAL PROTEIN 01/18/23 Crystal structure of SIV-1 V2 antibody NCI05 in complex with a V2 peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Zhou, T., Kwong, P.D., Van Wazer, D. 2.35 X-RAY DIFFRACTION 0.246 0.194 False True IGHV3 IGLV1 Lambda None None None None None 8fbw A B 0 F peptide NA siv v2 peptide IMMUNE SYSTEM/VIRAL PROTEIN 01/18/23 Crystal structure of SIV-1 V2 antibody NCI05 in complex with a V2 peptide Macaca mulatta; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Zhou, T., Kwong, P.D., Van Wazer, D. 2.35 X-RAY DIFFRACTION 0.246 0.194 False True IGHV3 IGLV1 Lambda None None None None None 8gni C NA 0 A protein NA nad(+) hydrolase sarm1 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8gnj C NA 0 A protein NA nad(+) hydrolase sarm1 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, Conformation 2 Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8gq5 a NA 0 A protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 b NA 0 B protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 c NA 0 C protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 d NA 0 D protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 e NA 0 E protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 f NA 0 F protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 g NA 0 G protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 h NA 0 H protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 i NA 0 I protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 j NA 0 J protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 k NA 0 K protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 l NA 0 L protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 m NA 0 M protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 n NA 0 N protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 o NA 0 O protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8gq5 p NA 0 P protein NA nanobody c6 HYDROLASE 01/18/23 Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Cai, Y., Zhang, H. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 8hdo N NA 0 A | B protein | protein NA | NA chimeric minigs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/18/23 Structure of A2BR bound to synthetic agonists BAY 60-6583 Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens | homo sapiens Cai, H., Xu, Y., Xu, H.E., Jiang, Y. 2.87 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8hdp N NA 0 A | B protein | protein NA | NA chimeric minigs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/18/23 Structure of A2BR bound to endogenous agonists adenosine Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens | homo sapiens Cai, H., Xu, Y., Xu, H.E., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7t82 D C 0 A protein NA leukocidin e TOXIN 01/11/23 Crystal Structure of LEUKOCIDIN E/CENTYRIN S26/FAB B438 mus musculus mus musculus staphylococcaceae Luo, J., Malia, T.J., Buckley, P.T. 3.5 X-RAY DIFFRACTION 0.279 0.229 False True IGHV1 IGKV1 Kappa None None None None None 7t82 H L 0 B protein NA leukocidin e TOXIN 01/11/23 Crystal Structure of LEUKOCIDIN E/CENTYRIN S26/FAB B438 mus musculus mus musculus staphylococcaceae Luo, J., Malia, T.J., Buckley, P.T. 3.5 X-RAY DIFFRACTION 0.279 0.229 False True IGHV1 IGKV1 Kappa None None None None None 7t86 H L 0 I peptide NA phospho-sd peptide TOXIN 01/11/23 Crystal Structure of Fab CR5133 / Phospho-SD Peptide Complex homo sapiens homo sapiens synthetic construct Luo, J., Malia, T.J., Buckley, P.T. 1.9 X-RAY DIFFRACTION 0.222 0.196 False True IGHV3 IGKV3 Kappa None None None None None 7t86 B A 0 J peptide NA phospho-sd peptide TOXIN 01/11/23 Crystal Structure of Fab CR5133 / Phospho-SD Peptide Complex homo sapiens homo sapiens synthetic construct Luo, J., Malia, T.J., Buckley, P.T. 1.9 X-RAY DIFFRACTION 0.222 0.196 False True IGHV3 IGKV3 Kappa None None None None None 7t86 D C 0 G peptide NA phospho-sd peptide TOXIN 01/11/23 Crystal Structure of Fab CR5133 / Phospho-SD Peptide Complex homo sapiens homo sapiens synthetic construct Luo, J., Malia, T.J., Buckley, P.T. 1.9 X-RAY DIFFRACTION 0.222 0.196 False True IGHV3 IGKV3 Kappa None None None None None 7t86 F E 0 K peptide NA phospho-sd peptide TOXIN 01/11/23 Crystal Structure of Fab CR5133 / Phospho-SD Peptide Complex homo sapiens homo sapiens synthetic construct Luo, J., Malia, T.J., Buckley, P.T. 1.9 X-RAY DIFFRACTION 0.222 0.196 False True IGHV3 IGKV3 Kappa None None None None None 7t87 H L 0 A | B protein | protein NA | NA leukocidin b | leukocidin a TOXIN 01/11/23 CRYSTAL STRUCTURE OF LEUKOCIDIN AB/CENTYRIN S17/FAB 214F COMPLEX mus musculus mus musculus staphylococcaceae | staphylococcaceae Luo, J., Malia, T.J., Buckley, P.T. 3 X-RAY DIFFRACTION 0.247 0.196 False True IGHV1 IGKV4 Kappa None None None None None 7u61 H L 0 NA NA NA NA IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Nicotine Antibody NIC311 Fab Complexed with Nicotine Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P., Liban, T.L. 2.1 X-RAY DIFFRACTION 0.264 0.230 False False IGHV4 IGLV1 Lambda None None None None None 7u62 H L 0 H Hapten MOI (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL IMMUNE SYSTEM 01/11/23 Crystal structure of Anti-Heroin Antibody HY4-1F9 Fab Complexed with Morphine Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.82 X-RAY DIFFRACTION 0.208 0.170 False False IGHV4 IGLV1 Lambda None None None None None 7u62 I M 0 NA NA NA NA IMMUNE SYSTEM 01/11/23 Crystal structure of Anti-Heroin Antibody HY4-1F9 Fab Complexed with Morphine Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.82 X-RAY DIFFRACTION 0.208 0.170 False False IGHV4 IGLV1 Lambda None None None None None 7u63 H L 0 H Hapten OOX 14-hydroxy-3-methoxy-17-methyl-5beta-4,5-epoxymorphinan-6-one IMMUNE SYSTEM 01/11/23 Crystal Structure Anti-Oxycodone Antibody HY2-A12 Fab Complexed with Oxycodone Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P., Weidle, C., Rupert, P.B., Strong, R.K. 2.3 X-RAY DIFFRACTION 0.282 0.226 False False IGHV1 IGLV1 Lambda None None None None None 7u63 B A 0 B Hapten OOX 14-hydroxy-3-methoxy-17-methyl-5beta-4,5-epoxymorphinan-6-one IMMUNE SYSTEM 01/11/23 Crystal Structure Anti-Oxycodone Antibody HY2-A12 Fab Complexed with Oxycodone Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P., Weidle, C., Rupert, P.B., Strong, R.K. 2.3 X-RAY DIFFRACTION 0.282 0.226 False False IGHV1 IGLV1 Lambda None None None None None 7u63 D C 0 D Hapten OOX 14-hydroxy-3-methoxy-17-methyl-5beta-4,5-epoxymorphinan-6-one IMMUNE SYSTEM 01/11/23 Crystal Structure Anti-Oxycodone Antibody HY2-A12 Fab Complexed with Oxycodone Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P., Weidle, C., Rupert, P.B., Strong, R.K. 2.3 X-RAY DIFFRACTION 0.282 0.226 False False IGHV1 IGLV1 Lambda None None None None None 7u64 A B 0 A Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 C D 0 C Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 E F 0 E Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 G H 0 G Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 I J 0 I Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 K L 0 K Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 M N 0 M Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 O P 0 O Hapten 7V7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7u64 Q R 0 NA NA NA NA IMMUNE SYSTEM 01/11/23 Crystal Structure of Anti-Fentanyl Antibody HY6-F9.6 Fab Complexed with Fentanyl Mus musculus mus musculus mus musculus Rodarte, J.V., Pancera, M.P. 1.75 X-RAY DIFFRACTION 0.225 0.197 False True IGHV3 IGKV2 Kappa None None None None None 7uih NA C 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING 01/11/23 PSMD2 Structure Homo sapiens homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 3.1 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 7uih D NA 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING 01/11/23 PSMD2 Structure Homo sapiens homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7uih NA E 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING 01/11/23 PSMD2 Structure Homo sapiens homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 3.1 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 7uih F NA 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING 01/11/23 PSMD2 Structure Homo sapiens homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ujd NA C 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING/Immune System 01/11/23 PSMD2 Structure bound to MC1 and Fab8/14 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 2.5 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 7ujd D NA 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING/Immune System 01/11/23 PSMD2 Structure bound to MC1 and Fab8/14 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ujd NA E 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING/Immune System 01/11/23 PSMD2 Structure bound to MC1 and Fab8/14 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 2.5 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 7ujd F NA 0 A protein NA 26s proteasome non-atpase regulatory subunit 2 PROTEIN BINDING/Immune System 01/11/23 PSMD2 Structure bound to MC1 and Fab8/14 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Johnson, M.C., Bashore, C., Ciferri, C., Dueber, E.C. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7uzc E F 0 B protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 01/11/23 Structure of the SARS-CoV-2 RBD in complex with the mouse antibody Fab fragment, M8a-34 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.2 X-RAY DIFFRACTION 0.243 0.172 False True IGHV1 IGKV3 Kappa None None None None None 7uzc H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 01/11/23 Structure of the SARS-CoV-2 RBD in complex with the mouse antibody Fab fragment, M8a-34 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 2.2 X-RAY DIFFRACTION 0.243 0.172 False True IGHV1 IGKV3 Kappa None None None None None 7uzd H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 01/11/23 Structure of the SARS-CoV-2 RBD in complex with the mouse antibody Fab fragment, HSW-2 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3 X-RAY DIFFRACTION 0.273 0.231 False True IGHV1 IGKV12 Kappa None None None None None 7x4i E NA 0 D protein NA spike glycoprotein ANTIVIRAL PROTEIN 01/11/23 Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV-1 RBD Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Ma, H., Zeng, W.H., Jin, T.C. 3.38 X-RAY DIFFRACTION 0.321 0.267 False True IGHV1 NA NA None None None None None 7x4i F NA 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN 01/11/23 Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV-1 RBD Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Ma, H., Zeng, W.H., Jin, T.C. 3.38 X-RAY DIFFRACTION 0.321 0.267 False True IGHV1 NA NA None None None None None 7x4i G NA 0 C protein NA spike glycoprotein ANTIVIRAL PROTEIN 01/11/23 Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV-1 RBD Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Ma, H., Zeng, W.H., Jin, T.C. 3.38 X-RAY DIFFRACTION 0.321 0.267 False True IGHV1 NA NA None None None None None 7x4i H NA 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN 01/11/23 Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV-1 RBD Severe acute respiratory syndrome coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus Ma, H., Zeng, W.H., Jin, T.C. 3.38 X-RAY DIFFRACTION 0.321 0.267 False True IGHV1 NA NA None None None None None 7xnf H L 0 A protein NA spike protein s1 VIRAL PROTEIN 01/11/23 Structure of SARS-CoV-2 antibody P2C-1F11 with GX/P2V/2017 RBD Homo sapiens; Pangolin coronavirus homo sapiens homo sapiens pangolin coronavirus Jia, Y.F., Chai, Y., Wang, Q.H., Gao, G.F. 2.79 X-RAY DIFFRACTION 0.380 0.320 False True IGHV3 IGKV3 Kappa None None None None None 7xsw H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/11/23 Structure of SARS-CoV-2 antibody S309 with GX/P2V/2017 RBD Homo sapiens; Pangolin coronavirus homo sapiens homo sapiens pangolin coronavirus Jia, Y.F., Chai, Y., Wang, Q.H., Gao, G.F. 3.3 X-RAY DIFFRACTION 0.322 0.277 False True IGHV1 IGKV3 Kappa None None None None None 7xsw A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/11/23 Structure of SARS-CoV-2 antibody S309 with GX/P2V/2017 RBD Homo sapiens; Pangolin coronavirus homo sapiens homo sapiens pangolin coronavirus Jia, Y.F., Chai, Y., Wang, Q.H., Gao, G.F. 3.3 X-RAY DIFFRACTION 0.322 0.277 False True IGHV1 IGKV3 Kappa None None None None None 7zlg H L 0 A protein NA c-mannosyltransferase dpy-19 MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with acceptor peptide and bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct synthetic construct caenorhabditis elegans Bloch, J.S., Mukherjee, S., Mao, R., Irobalieva, R., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zlg K NA 0 NA NA NA NA MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with acceptor peptide and bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct Bloch, J.S., Mukherjee, S., Mao, R., Irobalieva, R., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7zlh H L 0 A protein NA c-mannosyltransferase dpy-19 MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in apo state, bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct synthetic construct caenorhabditis elegans Bloch, J.S., Mukherjee, S., Irobalieva, R., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zlh K NA 0 NA NA NA NA MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in apo state, bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct Bloch, J.S., Mukherjee, S., Irobalieva, R., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7zli H L 0 A protein NA c-mannosyltransferase dpy-19 MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with Dol25-P-Man and bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct synthetic construct caenorhabditis elegans Bloch, J.S., Mukherjee, S., Boilevin, J., Irobalieva, R., Darbre, T., Reymond, J.L., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zli K NA 0 NA NA NA NA MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with Dol25-P-Man and bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct Bloch, J.S., Mukherjee, S., Boilevin, J., Irobalieva, R., Darbre, T., Reymond, J.L., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7zlj H L 0 A protein NA c-mannosyltransferase dpy-19 MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in ternary complex with Dol25-P-C-Man and acceptor peptide, bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct synthetic construct caenorhabditis elegans Bloch, J.S., Mao, R., Mukherjee, S., Boilevin, J., Irobalieva, R., Darbre, T., Reymond, J.L., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zlj K NA 0 NA NA NA NA MEMBRANE PROTEIN 01/11/23 Cryo-EM structure of C-mannosyltransferase CeDPY19, in ternary complex with Dol25-P-C-Man and acceptor peptide, bound to CMT2-Fab and anti-Fab nanobody Caenorhabditis elegans; synthetic construct synthetic construct Bloch, J.S., Mao, R., Mukherjee, S., Boilevin, J., Irobalieva, R., Darbre, T., Reymond, J.L., Kossiakoff, A.A., Goddard-Borger, E.D., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dv6 C L 0 B protein NA envelope protein e VIRAL PROTEIN 01/08/09 Zika virus envelope protein structure in complex with a potent Human mAb Homo sapiens; Zika virus ZIKV/Human/Cambodia/FSS13025/2010 homo sapiens homo sapiens zika virus zikv/human/cambodia/fss13025/2010 Cameron, A., Puhl, A.C., deSilva, A.M., Premkumar, L. 3.38 X-RAY DIFFRACTION 0.259 0.232 False True IGHV3 IGLV2 Lambda None None None None None 8dv6 H D 0 A protein NA envelope protein e VIRAL PROTEIN 01/08/09 Zika virus envelope protein structure in complex with a potent Human mAb Homo sapiens; Zika virus ZIKV/Human/Cambodia/FSS13025/2010 homo sapiens homo sapiens zika virus zikv/human/cambodia/fss13025/2010 Cameron, A., Puhl, A.C., deSilva, A.M., Premkumar, L. 3.38 X-RAY DIFFRACTION 0.259 0.232 False True IGHV3 IGLV2 Lambda None None None None None 7yar I M 0 C protein NA e protein VIRUS 01/04/23 ZIKV_Fab_G9E Homo sapiens; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Shu, B., Thiam-Seng, N., Lok, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7yar G H 0 A protein NA e protein VIRUS 01/04/23 ZIKV_Fab_G9E Homo sapiens; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Shu, B., Thiam-Seng, N., Lok, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7yar K L 0 B protein NA e protein VIRUS 01/04/23 ZIKV_Fab_G9E Homo sapiens; Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Shu, B., Thiam-Seng, N., Lok, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7ox1 A B 0 G protein NA interleukin-9 CYTOKINE 12/28/22 Fab 7D6: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 2.49 X-RAY DIFFRACTION 0.262 0.209 False True IGHV4 IGLV8 Lambda None None None None None 7ox1 C D 0 Z protein NA interleukin-9 CYTOKINE 12/28/22 Fab 7D6: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 2.49 X-RAY DIFFRACTION 0.262 0.209 False True IGHV4 IGLV8 Lambda None None None None None 7ox1 E F 0 Y protein NA interleukin-9 CYTOKINE 12/28/22 Fab 7D6: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 2.49 X-RAY DIFFRACTION 0.262 0.209 False True IGHV4 IGLV8 Lambda None None None None None 7ox1 H L 0 X protein NA interleukin-9 CYTOKINE 12/28/22 Fab 7D6: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 2.49 X-RAY DIFFRACTION 0.262 0.209 False True IGHV4 IGLV8 Lambda None None None None None 7ox2 A L 0 T protein NA interleukin-9 CYTOKINE 12/28/22 Fab 6E2: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 3.34 X-RAY DIFFRACTION 0.284 0.224 False True IGHV1 IGLV3 Lambda None None None None None 7ox2 B C 0 O protein NA interleukin-9 CYTOKINE 12/28/22 Fab 6E2: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 3.34 X-RAY DIFFRACTION 0.284 0.224 False True IGHV1 IGLV3 Lambda None None None None None 7ox2 D E 0 M protein NA interleukin-9 CYTOKINE 12/28/22 Fab 6E2: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 3.34 X-RAY DIFFRACTION 0.284 0.224 False True IGHV1 IGLV3 Lambda None None None None None 7ox2 J K 0 N protein NA interleukin-9 CYTOKINE 12/28/22 Fab 6E2: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 3.34 X-RAY DIFFRACTION 0.284 0.224 False True IGHV1 IGLV3 Lambda None None None None None 7ox3 A B 0 C protein NA interleukin-9 CYTOKINE 12/28/22 Fab 6D3: hIL-9 complex Homo sapiens homo sapiens homo sapiens homo sapiens De Vos, T., Savvides, S.N. 1.7 X-RAY DIFFRACTION 0.211 0.176 False True IGHV4 IGLV3 Lambda None None None None None 7ox4 A B 0 C protein NA interleukin-9 CYTOKINE 12/28/22 Mouse interleukin-9 in complex with Fab 35D8. Mus musculus mus musculus mus musculus mus musculus De Vos, T., Savvides, S.N. 1.8 X-RAY DIFFRACTION 0.229 0.183 False True IGHV4 IGLV3 Lambda None None None None None 7ust B NA 0 A protein NA gametocyte surface protein p230 PROTEIN BINDING/IMMUNE SYSTEM 12/28/22 Plasmodium falciparum protein Pfs230 D1 in complex with nanobody F5 Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Dietrich, M.H., Tham, W.H. 1.7 X-RAY DIFFRACTION 0.220 0.189 False True IGHV1 NA NA None None None None None 7usv D NA 0 B protein NA gametocyte surface protein p230 PROTEIN BINDING/IMMUNE SYSTEM 12/28/22 Plasmodium falciparum protein Pfs230 D1 in complex with nanobody F10 Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Dietrich, M.H., Tham, W.H. 2.1 X-RAY DIFFRACTION 0.235 0.198 False True IGHV1 NA NA None None None None None 7usv C NA 0 A protein NA gametocyte surface protein p230 PROTEIN BINDING/IMMUNE SYSTEM 12/28/22 Plasmodium falciparum protein Pfs230 D1 in complex with nanobody F10 Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Dietrich, M.H., Tham, W.H. 2.1 X-RAY DIFFRACTION 0.235 0.198 False True IGHV1 NA NA None None None None None 7wch D E 0 A protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWA9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wch H L 0 B protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWA9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wch M N 0 G protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWA9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 3.19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wck A B 0 R protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 Local CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWA9 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wcp D E 0 B protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWC11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7wcp H L 0 A protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWC11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7wcp M N 0 C protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWC11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7wcu A B 0 R protein NA surface glycoprotein VIRAL PROTEIN 12/28/22 Local CryoEM structure of the SARS-CoV-2 S6P(B.1.617.2) in complex with SWC11 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7xw9 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 12/28/22 Cryo-EM structure of the TRH-bound human TRHR-Gq complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Ji, S., Dong, Y., Chen, L., Zang, S., Shen, D., Guo, J., Qin, J., Zhang, H., Wang, W., Shen, Q., Mao, C., Zhang, Y. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ykj A D 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/28/22 Omicron RBDs bound with P3E6 Fab (one up and one down) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tang, B., Dang, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8b7w H NA 0 C protein NA interleukin-17a IMMUNE SYSTEM/INHIBITOR 12/28/22 Complex IL-17A/anti-IL-17A-76 Homo sapiens; Lama glama lama glama homo sapiens Kostareva, O.S., Svoeglazova, A., Kolyadenko, I.A., Dzhus, U.F., Tishchenko, S.V., Gabdulkhakov, A.G. 2.85 X-RAY DIFFRACTION 0.265 0.222 False True IGHV1 NA NA None None None None None 8gv6 G H 0 D | C protein | protein NA | NA hemagglutinin h14-ha2 | hemagglutinin h14-ha1 VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 Crystal structure of PN-SIA28 in complex with influenza hemagglutinin H14 (A/long-tailed duck/Wisconsin/10OS3912/2010) Homo sapiens; Influenza A virus (A/long-tailed duck/Wisconsin/10OS3912/2010(H14N6)) homo sapiens homo sapiens influenza a virus (a/long-tailedduck/wisconsin/10os3912/2010(h14n6)) | influenza a virus (a/long-tailedduck/wisconsin/10os3912/2010(h14n6)) Chen, Y., Song, H., Qi, J., Gao, G.F. 3.4 X-RAY DIFFRACTION 0.261 0.221 False True IGHV3 IGKV1 Kappa None None None None None 8gv6 I J 0 F | E | A protein | protein | protein NA | NA | NA hemagglutinin h14-ha2 | hemagglutinin h14-ha1 | hemagglutinin h14-ha1 VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 Crystal structure of PN-SIA28 in complex with influenza hemagglutinin H14 (A/long-tailed duck/Wisconsin/10OS3912/2010) Homo sapiens; Influenza A virus (A/long-tailed duck/Wisconsin/10OS3912/2010(H14N6)) homo sapiens homo sapiens influenza a virus (a/long-tailedduck/wisconsin/10os3912/2010(h14n6)) | influenza a virus (a/long-tailedduck/wisconsin/10os3912/2010(h14n6)) | influenza a virus (a/long-tailedduck/wisconsin/10os3912/2010(h14n6)) Chen, Y., Song, H., Qi, J., Gao, G.F. 3.4 X-RAY DIFFRACTION 0.261 0.221 False True IGHV3 IGKV1 Kappa None None None None None 8hao F NA 0 C | D protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 LIPID BINDING PROTEIN/HORMONE/IMMUNE SYSTEM 12/21/22 Human parathyroid hormone receptor-1 dimer Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Zhao, L., Xu, H.E., Yuan, Q. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8hao N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 LIPID BINDING PROTEIN/HORMONE/IMMUNE SYSTEM 12/21/22 Human parathyroid hormone receptor-1 dimer Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Zhao, L., Xu, H.E., Yuan, Q. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7qha C NA 0 B | A protein | protein NA | NA putative trap-type c4-dicarboxylate transport system, largepermease component | putative trap-type c4-dicarboxylate transport system, smallpermease component TRANSPORT PROTEIN 12/21/22 Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Photobacterium profundum in amphipol Helicobacter pylori; Photobacterium profundum SS9; synthetic construct helicobacter pylori, synthetic construct photobacterium profundum ss9 | photobacterium profundum ss9 North, R.A., Davies, J.S., Morado, D., Dobson, R.C.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7t72 H L 0 A protein NA spike protein s1 VIRAL PROTEIN 12/21/22 Epitope-based selection of SARS-CoV-2 neutralizing antibodies from convalescent patients Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D., Rouet, R. 3.177 X-RAY DIFFRACTION 0.308 0.237 False True IGHV3 IGKV1 Kappa None None None None None 7utg A NA 0 NA NA NA NA PEPTIDE BINDING PROTEIN 12/21/22 2D9 nanobody to BCL11A-exZF23 fragment Vicugna pacos vicugna pacos Dassama, L.M.K., Zhai, L. 1.25 X-RAY DIFFRACTION 0.219 0.193 False True IGHV1 NA NA None None None None None 7wcm N NA 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/21/22 Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Qiao, A.N., Wu, S., Ye, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wcn N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/21/22 Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453 Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Qiao, A.N., Wu, S., Ye, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wd1 C NA 0 B protein NA spike protein s1 VIRAL PROTEIN 12/21/22 Crystal structure of R14 bound to SARS-CoV-2 RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, Q.H., Gao, G.F., Qi, J.X., Su, C., Liu, H.H., Wu, L.L. 2.5 X-RAY DIFFRACTION 0.240 0.201 False True IGHV1 NA NA None None None None None 7wd1 D NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/21/22 Crystal structure of R14 bound to SARS-CoV-2 RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, Q.H., Gao, G.F., Qi, J.X., Su, C., Liu, H.H., Wu, L.L. 2.5 X-RAY DIFFRACTION 0.240 0.201 False True IGHV1 NA NA None None None None None 7wd2 C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 12/21/22 Crystal structure of S43 bound to SARS-CoV-2 RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, Q.H., Gao, G.F., Qi, J.X., Su, C., Liu, H.H., Wu, L.L. 2.69 X-RAY DIFFRACTION 0.229 0.204 False True IGHV1 NA NA None None None None None 7wd2 D NA 0 B protein NA spike protein s1 VIRAL PROTEIN 12/21/22 Crystal structure of S43 bound to SARS-CoV-2 RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, Q.H., Gao, G.F., Qi, J.X., Su, C., Liu, H.H., Wu, L.L. 2.69 X-RAY DIFFRACTION 0.229 0.204 False True IGHV1 NA NA None None None None None 7wti H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv264 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7wti I K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv264 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7wti G J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv264 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7wur E F 0 A protein NA core protein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 CryoEM structure of sNS1 complexed with Fab5E3 Dengue virus 2; Homo sapiens homo sapiens homo sapiens dengue virus 2 Shu, B., Lok, S.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7wur G H 0 B protein NA core protein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 CryoEM structure of sNS1 complexed with Fab5E3 Dengue virus 2; Homo sapiens homo sapiens homo sapiens dengue virus 2 Shu, B., Lok, S.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7x2j B NA 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 Crystal structure of nanobody Nb70 with SARS-CoV RBD Severe acute respiratory syndrome-related coronavirus; Vicugna pacos vicugna pacos severe acute respiratory syndrome-relatedcoronavirus Wang, X.Q., Zhang, L.Q., Ren, Y.F., Li, M.X. 2.4 X-RAY DIFFRACTION 0.235 0.197 False True IGHV1 NA NA None None None None None 7x2k H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 Crystal structure of nanobody Nb70 with antibody 1F11 fab and SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.Q., Zhang, L.Q., Ren, Y.F., Li, M.X. 2.4 X-RAY DIFFRACTION 0.245 0.195 False True IGHV3 IGKV3 Kappa None None None None None 7x2k B NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 Crystal structure of nanobody Nb70 with antibody 1F11 fab and SARS-CoV-2 RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, X.Q., Zhang, L.Q., Ren, Y.F., Li, M.X. 2.4 X-RAY DIFFRACTION 0.245 0.195 False True IGHV1 NA NA None None None None None 8bbh H L 0 A peptide NA glucose-6-phosphate isomerase IMMUNE SYSTEM 12/21/22 The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307 Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Changrong, G., Rikard, H., Taotao, L. 1.619 X-RAY DIFFRACTION 0.229 0.198 False False IGHV9 IGKV1 Kappa None None None None None 8d47 H L 0 C peptide NA sars-cov-2 fusion peptide ANTIVIRAL PROTEIN 12/21/22 fp.006 Fab in complex with SARS-CoV-2 Fusion Peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Abernathy, M.E., Barnes, C.O. 2 X-RAY DIFFRACTION 0.238 0.184 False True IGHV3 IGKV3 Kappa None None None None None 8d47 B A 0 D peptide NA sars-cov-2 fusion peptide ANTIVIRAL PROTEIN 12/21/22 fp.006 Fab in complex with SARS-CoV-2 Fusion Peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Abernathy, M.E., Barnes, C.O. 2 X-RAY DIFFRACTION 0.238 0.184 False True IGHV3 IGKV3 Kappa None None None None None 8dam B NA 0 A protein NA voltage-dependent l-type calcium channel subunit beta-1 TRANSPORT PROTEIN/IMMUNE SYSTEM 12/21/22 nbF3:nbE8:CaV beta subunit 1b complex Lama glama; Mus musculus lama glama mus musculus Nirwan, N., Minor, D.L. 2 X-RAY DIFFRACTION 0.227 0.193 False True IGHV1 NA NA None None None None None 8dam C NA 0 A protein NA voltage-dependent l-type calcium channel subunit beta-1 TRANSPORT PROTEIN/IMMUNE SYSTEM 12/21/22 nbF3:nbE8:CaV beta subunit 1b complex Lama glama; Mus musculus lama glama mus musculus Nirwan, N., Minor, D.L. 2 X-RAY DIFFRACTION 0.227 0.193 False True IGHV1 NA NA None None None None None 8gv4 A B 0 NA NA NA NA IMMUNE SYSTEM 12/21/22 A human broadly neutralizing influenza A hemagglutinin stem-specific antibody PN-SIA28 Homo sapiens homo sapiens homo sapiens Chen, Y., Song, H., Qi, J., Gao, G.F. 2.5 X-RAY DIFFRACTION 0.230 0.195 False True IGHV3 IGKV1 Kappa None None None None None 8gv4 C D 0 NA NA NA NA IMMUNE SYSTEM 12/21/22 A human broadly neutralizing influenza A hemagglutinin stem-specific antibody PN-SIA28 Homo sapiens homo sapiens homo sapiens Chen, Y., Song, H., Qi, J., Gao, G.F. 2.5 X-RAY DIFFRACTION 0.230 0.195 False True IGHV3 IGKV1 Kappa None None None None None 8gv5 C D 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 Crystal structure of PN-SIA28 in complex with influenza hemagglutinin A/swine/Guangdong/104/2013 (H1N1) Homo sapiens; Influenza A virus (A/swine/Guangdong/104/2013(H1N1)) homo sapiens homo sapiens influenza a virus(a/swine/guangdong/104/2013(h1n1)) | influenza a virus(a/swine/guangdong/104/2013(h1n1)) Chen, Y., Song, H., Qi, J., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.308 0.267 False True IGHV3 IGKV1 Kappa None None None None None 8gv7 C D 0 B | A protein | protein NA | NA hemagglutinin h18-ha2 | hemagglutinin h18-ha1 VIRAL PROTEIN/IMMUNE SYSTEM 12/21/22 Crystal structure of PN-SIA28 in complex with influenza hemagglutinin H18 A/flat-faced bat/Peru/033/2010 Homo sapiens; Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11)) homo sapiens homo sapiens influenza a virus (a/flat-facedbat/peru/033/2010(h18n11)) | influenza a virus (a/flat-facedbat/peru/033/2010(h18n11)) Chen, Y., Song, H., Qi, J., Gao, G.F. 2.6 X-RAY DIFFRACTION 0.222 0.209 False True IGHV3 IGKV1 Kappa None None None None None 8gz3 N NA 0 L | H protein | protein NA | NA 7d5 fab light chain | 7d5 fab heavy chain OXIDOREDUCTASE 12/21/22 Structure of human phagocyte NADPH oxidase in the resting state Homo sapiens; Mus musculus; Vicugna pacos vicugna pacos mus musculus | mus musculus Chen, L., Liu, R. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8ha0 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 LIPID BINDING PROTEIN/HORMONE/IMMUNE SYSTEM 12/21/22 Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1 Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Zhao, L., Xu, H.E., Yuan, Q. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8haf N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 LIPID BINDING PROTEIN/HORMONE/IMMUNE SYSTEM 12/21/22 PTHrP-PTH1R-Gs complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Zhao, L., Xu, H.E., Yuan, Q. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8hii H L 0 A protein NA bril-slc19a1 chimera TRANSPORT PROTEIN 12/21/22 The BRIL-SLC19A1/Fab/Nb ternary complex Escherichia coli; Homo sapiens; Lama glama homo sapiens homo sapiens escherichia coli, homo sapiens Zhang, Z., Dang, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hii N NA 0 NA NA NA NA TRANSPORT PROTEIN 12/21/22 The BRIL-SLC19A1/Fab/Nb ternary complex Escherichia coli; Homo sapiens; Lama glama lama glama Zhang, Z., Dang, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hij H L 0 A protein NA bril-slc19a1 chimera TRANSPORT PROTEIN 12/21/22 The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex Escherichia coli; Homo sapiens; Lama glama homo sapiens homo sapiens escherichia coli, homo sapiens Zhang, Z., Dang, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hij N NA 0 NA NA NA NA TRANSPORT PROTEIN 12/21/22 The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex Escherichia coli; Homo sapiens; Lama glama lama glama Zhang, Z., Dang, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8hik H L 0 A protein NA bril-slc19a1 chimera TRANSPORT PROTEIN 12/21/22 The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex Escherichia coli; Homo sapiens; Lama glama homo sapiens homo sapiens escherichia coli, homo sapiens Zhang, Z., Dang, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8hik N NA 0 NA NA NA NA TRANSPORT PROTEIN 12/21/22 The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex Escherichia coli; Homo sapiens; Lama glama lama glama Zhang, Z., Dang, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8gsf H L 0 A | C protein | protein NA | NA vp1 | vp3 VIRUS/IMMUNE SYSTEM 12/14/22 Echovirus3 empty particle in complex with 6D10 Fab (sideling) Echovirus E3; Mus musculus mus musculus mus musculus echovirus e3 | echovirus e3 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 8gsf E F 0 1 | 3 protein | protein NA | NA vp1 | vp3 VIRUS/IMMUNE SYSTEM 12/14/22 Echovirus3 empty particle in complex with 6D10 Fab (sideling) Echovirus E3; Mus musculus mus musculus mus musculus echovirus e3 | echovirus e3 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7t25 H L 0 E protein NA outer surface protein a IMMUNE SYSTEM 12/14/22 OspA-Fab 319-44 complex structure Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J. 2.25 X-RAY DIFFRACTION 0.233 0.191 False True IGHV5 IGKV3 Kappa None None None None None 7t25 A B 0 C protein NA outer surface protein a IMMUNE SYSTEM 12/14/22 OspA-Fab 319-44 complex structure Borreliella burgdorferi B31; Homo sapiens homo sapiens homo sapiens borreliella burgdorferi b31 Rudolph, M.J. 2.25 X-RAY DIFFRACTION 0.233 0.191 False True IGHV5 IGKV3 Kappa None None None None None 7u5b A B 0 J protein NA kallikrein-5 HYDROLASE/IMMUNE SYSTEM 12/14/22 Structure of Human KLK5 bound to anti-KLK5 Fab Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Yin, J., Sudhamsu, J. 2.371 X-RAY DIFFRACTION 0.270 0.222 False True IGHV3 IGKV1 Kappa None None None None None 7u5b H L 0 I protein NA kallikrein-5 HYDROLASE/IMMUNE SYSTEM 12/14/22 Structure of Human KLK5 bound to anti-KLK5 Fab Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Yin, J., Sudhamsu, J. 2.371 X-RAY DIFFRACTION 0.270 0.222 False True IGHV3 IGKV1 Kappa None None None None None 7wtf H L 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/14/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv051 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wtf G J 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/14/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv051 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wtf I K 0 D protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/14/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv051 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wtg H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv051 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7wth H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv264 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7wtj H L 0 E protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/14/22 SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv286 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7wtk H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv286 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7wtk G J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv286 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7wtk I K 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 SARS-CoV-2 Omicron variant spike in complex with Fab XGv286 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7x2m B NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 Crystal structure of nanobody 1-2C7 with SARS-CoV-2 RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, X.Q., Zhang, L.Q., Ren, Y.F., Li, M.X. 1.8 X-RAY DIFFRACTION 0.207 0.180 False True IGHV1 NA NA None None None None None 8b41 G NA 0 A protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 12/14/22 Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 Mus musculus; Synthetic construct synthetic construct mus musculus Sawicka, M., Dutzler, R. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8b41 H NA 0 B protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 12/14/22 Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 Mus musculus; Synthetic construct synthetic construct mus musculus Sawicka, M., Dutzler, R. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8b41 I NA 0 C protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 12/14/22 Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 Mus musculus; Synthetic construct synthetic construct mus musculus Sawicka, M., Dutzler, R. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8b41 J NA 0 D protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 12/14/22 Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 Mus musculus; Synthetic construct synthetic construct mus musculus Sawicka, M., Dutzler, R. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8d54 A B 0 NA NA NA NA IMMUNE SYSTEM 12/14/22 anti HIV gp120/CD4 complex antibody CG10 Fab Mus musculus mus musculus mus musculus Yang, Z., Bjorkman, P.J. 1.4 X-RAY DIFFRACTION 0.188 0.169 False True IGHV1 IGKV3 Kappa None None None None None 8ddk A B 0 C protein NA envelopment polyprotein VIRAL PROTEIN 12/14/22 CCHFV GP38 Hoti/Kosovo bound with CC5_17 Crimean-Congo hemorrhagic fever orthonairovirus; Homo sapiens homo sapiens homo sapiens crimean-congo hemorrhagic feverorthonairovirus Durie, I.A., Bergeron, E., Pegan, S.D., McGuire, J. 3.86 X-RAY DIFFRACTION 0.335 0.304 False True IGHV5 IGKV1 Kappa None None None None None 8diu G C 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 Cryo-EM structure of influenza A virus A/Bayern/7/1995 hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8diu E F 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 Cryo-EM structure of influenza A virus A/Bayern/7/1995 hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8diu H I 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 Cryo-EM structure of influenza A virus A/Bayern/7/1995 hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8f7q E e 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 12/14/22 Gi bound mu-opioid receptor in complex with beta-endorphin Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus | bos taurus Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E. 3.22 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8f7r E e 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 12/14/22 Gi bound mu-opioid receptor in complex with endomorphin Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus | bos taurus Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E. 3.28 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8f7w E e 0 A | B | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 12/14/22 Gi bound kappa-opioid receptor in complex with dynorphin Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus | bos taurus Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8f7x E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/14/22 Gi bound nociceptin receptor in complex with nociceptin peptide Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E. 3.28 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gsc H L 0 1 | 3 protein | protein NA | NA vp1 | vp3 VIRUS/IMMUNE SYSTEM 12/14/22 Echovirus3 A-particle in complex with 6D10 Fab Echovirus E3; Mus musculus mus musculus mus musculus echovirus e3 | echovirus e3 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 8gsd H L 0 1 | 3 protein | protein NA | NA genome polyprotein (fragment) | genome polyprotein VIRUS/IMMUNE SYSTEM 12/14/22 Echovirus3 full particle in complex with 6D10 Fab Echovirus E3; Mus musculus mus musculus mus musculus echovirus e3 | echovirus e3 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 8gse H L 0 1 | 3 protein | protein NA | NA vp1 | vp3 VIRAL PROTEIN/IMMUNE SYSTEM 12/14/22 Echovirus3 capsid protein in complex with 6D10 Fab (upright) Echovirus E3; Mus musculus mus musculus mus musculus echovirus e3 | echovirus e3 Wang, X., Fu, W. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7t0l G K 0 E | D protein | protein NA | NA beta-2-microglobulin | mhc class i antigen IMMUNE SYSTEM 12/07/22 HLA-B*27:05 in complex with the pan-HLA-Ia monoclonal antibody W6/32 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Vivian, J.P., Rossjohn, J. 3 X-RAY DIFFRACTION 0.252 0.198 False False IGHV2 IGKV6 Kappa None None None None None 7t0l H L 0 B | A protein | protein NA | NA beta-2-microglobulin | mhc class i antigen IMMUNE SYSTEM 12/07/22 HLA-B*27:05 in complex with the pan-HLA-Ia monoclonal antibody W6/32 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Vivian, J.P., Rossjohn, J. 3 X-RAY DIFFRACTION 0.252 0.198 False False IGHV2 IGKV6 Kappa None None None None None 7t1w H L 0 A carbohydrate BXX BETA-D-ARABINOFURANOSE IMMUNE SYSTEM 01/08/09 Crystal structure of human Fab A194-01 in complex with its synthetic tetrasaccharide Ara4 epitope (BSI110886) Homo sapiens homo sapiens homo sapiens Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.45 X-RAY DIFFRACTION 0.218 0.168 False True IGHV3 IGKV3 Kappa None None None None None 7t1x H L 0 A carbohydrate BXX BETA-D-ARABINOFURANOSE IMMUNE SYSTEM 01/08/09 Crystal structure of human Fab A194-01 in complex with its synthetic heptasaccharide Ara6-Man epitope (BSI110888) Homo sapiens homo sapiens homo sapiens Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 X-RAY DIFFRACTION 0.216 0.159 False True IGHV3 IGKV3 Kappa None None None None None 7df1 H L 0 D protein NA 4f2 cell-surface antigen heavy chain ANTITUMOR PROTEIN 12/07/22 Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv Homo sapiens homo sapiens homo sapiens homo sapiens Liu, X., Ding, J., Sui, J., Tian, X. 2.806 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 IGKV4 Kappa None None None None None 7df1 E I 0 NA NA NA NA ANTITUMOR PROTEIN 12/07/22 Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv Homo sapiens homo sapiens homo sapiens Liu, X., Ding, J., Sui, J., Tian, X. 2.806 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 IGKV4 Kappa None None None None None 7df1 F J 0 C protein NA 4f2 cell-surface antigen heavy chain ANTITUMOR PROTEIN 12/07/22 Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv Homo sapiens homo sapiens homo sapiens homo sapiens Liu, X., Ding, J., Sui, J., Tian, X. 2.806 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 IGKV4 Kappa None None None None None 7df1 G K 0 D protein NA 4f2 cell-surface antigen heavy chain ANTITUMOR PROTEIN 12/07/22 Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv Homo sapiens homo sapiens homo sapiens homo sapiens Liu, X., Ding, J., Sui, J., Tian, X. 2.806 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 IGKV4 Kappa None None None None None 7t2h E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/07/22 CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Seven, A.B., Qu, Q., Huang, W., Robertson, M.J., Kobilka, B.K., Skiniotis, G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7t83 A NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t83 B NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t83 C NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t83 D NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t83 E NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t83 F NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t83 G NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t83 H NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 synthetic construct synthetic construct Skiba, M.A., Kruse, A.C. 2.1 X-RAY DIFFRACTION 0.257 0.208 False True IGHV3 NA NA None None None None None 7t84 A NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7t84 B NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7t84 C NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7t84 D NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7t84 E NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7t84 F NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7t84 G NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7t84 H NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Structure of angiotensin II type I receptor (AT1R) nanobody antagonist AT118i4h32 G26D T57I variant synthetic construct synthetic construct Nemeth, G.R., Skiba, M.A., Kruse, A.C. 1.6 X-RAY DIFFRACTION 0.190 0.165 False True IGHV3 NA NA None None None None None 7uz4 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-3 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7uz4 M N 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-3 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7uz4 P Q 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-3 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7uz5 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-6 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7uz6 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-28 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 7uz6 M N 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-28 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 7uz6 P Q 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-28 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 7uz7 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV8 Kappa None None None None None 7uz7 M N 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV8 Kappa None None None None None 7uz7 P Q 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV8 Kappa None None None None None 7uz8 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 Omicron BA.1 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV8 Kappa None None None None None 7uz8 M N 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 Omicron BA.1 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV8 Kappa None None None None None 7uz8 P Q 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 Omicron BA.1 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV8 Kappa None None None None None 7uz9 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-34 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uz9 M N 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-34 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uz9 P Q 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-34 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uza H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, HSW-1 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uzb H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/07/22 Structure of the SARS-CoV-2 S S1 doamin in complex with the mouse antibody Fab fragment, HSW-2 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7w7q A a 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Crystal structure of 1F11S antibody(ScFv) Mus musculus mus musculus Kim, B.-W., Park, J., Woo, J., Lee, W.-K. 1.96 X-RAY DIFFRACTION 0.277 0.224 True True unknown unknown unknown None None None None None 7w7q B b 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Crystal structure of 1F11S antibody(ScFv) Mus musculus mus musculus Kim, B.-W., Park, J., Woo, J., Lee, W.-K. 1.96 X-RAY DIFFRACTION 0.277 0.224 True True unknown unknown unknown None None None None None 7wvl H L 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Structure of P4A2 Fab in complex with Spike-RBD from SARS-CoV-2 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Narayanan, N., Nair, D.T. 3 X-RAY DIFFRACTION 0.279 0.233 False True IGHV1 IGKV3 Kappa None None None None None 7x2l B NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Crystal structure of nanobody 3-2A2-4 with SARS-CoV-2 RBD Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, X.Q., Zhang, L.Q., Ren, Y.F., Li, M.X. 2.4 X-RAY DIFFRACTION 0.287 0.230 False True IGHV1 NA NA None None None None None 7x8w H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/07/22 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab354 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7x8y H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/07/22 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab159 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7x8z H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/07/22 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab188 Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 7x90 E F 0 G protein NA spike glycoprotein VIRAL PROTEIN 12/07/22 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab326 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7x91 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/07/22 The SARS-CoV-2 receptor binding domain bound with an Fv-clasp form of a human neutralizing antibody Ab496 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7x92 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/07/22 The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab445 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kamada, K., Shirouzu, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dcy A B 0 C protein NA envelopment polyprotein VIRAL PROTEIN 12/07/22 CCHFV GP38 Hoti/Kosovo bound with 13G8 Fab Crimean-Congo hemorrhagic fever orthonairovirus; Mus musculus mus musculus mus musculus crimean-congo hemorrhagic feverorthonairovirus Durie, I.A., Bergeron, E., Pegan, S.D., McGuire, J. 3.62 X-RAY DIFFRACTION 0.299 0.281 False True IGHV2 IGKV4 Kappa None None None None None 8dl7 D C 0 A protein NA solute carrier family 40 member 1 MEMBRANE PROTEIN 12/07/22 Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Shen, J., Wilbon, A.S., Pan, Y., Zhou, M. 0 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 8dl8 D C 0 A protein NA solute carrier family 40 member 1 MEMBRANE PROTEIN 12/07/22 Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Shen, J., Wilbon, A.S., Pan, Y., Zhou, M. 0 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 8dw2 D C 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kwon, Y.D., Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dw2 H L 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR22, and two antibody Fabs, S309 and CR3022 Homo sapiens; Severe acute respiratory syndrome coronavirus 2; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kwon, Y.D., Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8dw3 D C 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kwon, Y.D., Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dw3 H L 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kwon, Y.D., Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 8dw9 C D 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Crystal structure of neutralizing antibody D29 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 4 X-RAY DIFFRACTION 0.381 0.300 False True IGHV1 IGKV3 Kappa None None None None None 8dw9 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Crystal structure of neutralizing antibody D29 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 4 X-RAY DIFFRACTION 0.381 0.300 False True IGHV1 IGKV3 Kappa None None None None None 8dwa H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Crystal structure of neutralizing antibody P1D9 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.2 X-RAY DIFFRACTION 0.297 0.235 False True IGHV1 IGKV1 Kappa None None None None None 8dxs H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 8dxs F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dxs NA I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.76 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 8dxs G NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dxs NA J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.76 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 8e99 E NA 0 B protein NA glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN/IMMUNE SYSTEM 12/07/22 Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4 Homo sapiens; Lama glama lama glama homo sapiens Chou, T.-H., Furukawa, H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8gz5 B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/07/22 Crystal structure of neutralizing VHH P17 in complex with SARS-CoV-2 Alpha variant spike receptor-binding domain Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Yamaguchi, K., Anzai, I., Maeda, R., Moriguchi, M., Watanabe, T., Imura, A., Takaori-Kondo, A., Inoue, T. 1.7 X-RAY DIFFRACTION 0.189 0.171 False True IGHV1 NA NA None None None None None 8gz6 A NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Crystal structure of neutralizing VHH P17 in complex with SARS-CoV-2 Alpha variant spike receptor-binding domain Vicugna pacos vicugna pacos Yamaguchi, K., Anzai, I., Maeda, R., Moriguchi, M., Watanabe, T., Imura, A., Takaori-Kondo, A., Inoue, T. 1.35 X-RAY DIFFRACTION 0.180 0.149 False True IGHV1 NA NA None None None None None 8gz6 B NA 0 NA NA NA NA IMMUNE SYSTEM 12/07/22 Crystal structure of neutralizing VHH P17 in complex with SARS-CoV-2 Alpha variant spike receptor-binding domain Vicugna pacos vicugna pacos Yamaguchi, K., Anzai, I., Maeda, R., Moriguchi, M., Watanabe, T., Imura, A., Takaori-Kondo, A., Inoue, T. 1.35 X-RAY DIFFRACTION 0.180 0.149 False True IGHV1 NA NA None None None None None 7wos D d 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 3 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wos E e 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 3 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wos F f 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 3 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wos G g 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 3 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7sx6 H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM/VIRAL PROTEIN 11/30/22 Crystal structure of broadly neutralizing antibody N49P9.3 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 3.4 X-RAY DIFFRACTION 0.287 0.234 False True unknown unknown unknown None None None None None 7sx6 B C 0 A protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM/VIRAL PROTEIN 11/30/22 Crystal structure of broadly neutralizing antibody N49P9.3 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 3.4 X-RAY DIFFRACTION 0.287 0.234 False True unknown unknown unknown None None None None None 7sx7 H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM/VIRAL PROTEIN 11/30/22 Crystal structure of broadly neutralizing antibody N49P9.3-FR3-3 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core Homo; Homo sapiens; Human immunodeficiency virus 1 homo homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 2.15 X-RAY DIFFRACTION 0.266 0.209 False True unknown unknown unknown None None None None None 7sx7 B C 0 A protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM/VIRAL PROTEIN 11/30/22 Crystal structure of broadly neutralizing antibody N49P9.3-FR3-3 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core Homo; Homo sapiens; Human immunodeficiency virus 1 homo homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 2.15 X-RAY DIFFRACTION 0.266 0.209 False True unknown unknown unknown None None None None None 7wop B b 0 A protein NA spike protein s1 VIRAL PROTEIN 11/30/22 The local refined map of Omicron spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wop C c 0 A protein NA spike protein s1 VIRAL PROTEIN 11/30/22 The local refined map of Omicron spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7woq D d 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 1 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wor D d 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 2 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wor E e 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 2 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wor F f 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 2 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wou D d 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 4 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wou E e 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 4 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wou F f 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 4 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wou G g 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 4 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wov D d 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 5 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Sun, L., Chen, Z.G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wov E e 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 5 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Sun, L., Chen, Z.G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wov F f 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 5 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Sun, L., Chen, Z.G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wov G g 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 5 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Sun, L., Chen, Z.G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wov H h 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 5 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Sun, L., Chen, Z.G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wov I i 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 5 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Sun, L., Chen, Z.G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow D d 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow E e 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow F f 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow G g 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow H h 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow I i 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow M m 0 J protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow N n 0 J protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow O o 0 K protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow P p 0 K protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow Q q 0 L protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wow R r 0 L protein NA spike glycoprotein VIRAL PROTEIN 11/30/22 The state 6 of Omicron Spike with bispecific antibody FD01 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, X., Zhan, W.Q., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8d29 A B 0 C nucleic-acid NA rna (34-mer) RNA/IMMUNE SYSTEM 11/30/22 Crystal structure of theophylline aptamer - apo form Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Menichelli, E., Spraggon, G. 1.81 X-RAY DIFFRACTION 0.211 0.176 False True IGHV3 IGKV1 Kappa None None None None None 8d29 D E 0 F nucleic-acid NA rna (34-mer) RNA/IMMUNE SYSTEM 11/30/22 Crystal structure of theophylline aptamer - apo form Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Menichelli, E., Spraggon, G. 1.81 X-RAY DIFFRACTION 0.211 0.176 False True IGHV3 IGKV1 Kappa None None None None None 8d29 G I 0 J nucleic-acid NA rna (34-mer) RNA/IMMUNE SYSTEM 11/30/22 Crystal structure of theophylline aptamer - apo form Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Menichelli, E., Spraggon, G. 1.81 X-RAY DIFFRACTION 0.211 0.176 False True IGHV3 IGKV1 Kappa None None None None None 8d29 H L 0 R nucleic-acid NA rna (34-mer) RNA/IMMUNE SYSTEM 11/30/22 Crystal structure of theophylline aptamer - apo form Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Menichelli, E., Spraggon, G. 1.81 X-RAY DIFFRACTION 0.211 0.176 False True IGHV3 IGKV1 Kappa None None None None None 8dk7 B A 0 C nucleic-acid NA rna (34-mer) RNA/IMMUNE SYSTEM 11/30/22 Crystal structure of theophylline aptamer soaked with TAL2 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Menichelli, E., Spraggon, G. 2.46 X-RAY DIFFRACTION 0.270 0.246 False True IGHV3 IGKV1 Kappa None None None None None 8dk7 D E 0 F nucleic-acid NA rna (34-mer) RNA/IMMUNE SYSTEM 11/30/22 Crystal structure of theophylline aptamer soaked with TAL2 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Menichelli, E., Spraggon, G. 2.46 X-RAY DIFFRACTION 0.270 0.246 False True IGHV3 IGKV1 Kappa None None None None None 8e9w E e 0 B | C protein | protein NA | NA minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/30/22 CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, S., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8e9x E e 0 B | C protein | protein NA | NA minigo | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/30/22 CryoEM structure of miniGo-coupled hM4Di in complex with DCZ Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, S., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8e9y E e 0 B | C protein | protein NA | NA minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/30/22 CryoEM structure of miniGq-coupled hM3Dq in complex with CNO Homo sapiens homo sapiens homo sapiens | homo sapiens Zhang, S., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8e9z E e 0 B | C protein | protein NA | NA minigq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/30/22 CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, S., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8eb2 J L 0 D protein NA hla-a*02 IMMUNE SYSTEM 11/30/22 Structure of HLA-A*02:01 in complex with NY-ESO-1 peptide and PA2.1 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Jette, C.J., West, A.P. 2.9 X-RAY DIFFRACTION 0.284 0.239 False True IGHV1 IGKV1 Kappa None None None None None 8eb2 K M 0 A protein NA hla-a*02 IMMUNE SYSTEM 11/30/22 Structure of HLA-A*02:01 in complex with NY-ESO-1 peptide and PA2.1 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Jette, C.J., West, A.P. 2.9 X-RAY DIFFRACTION 0.284 0.239 False True IGHV1 IGKV1 Kappa None None None None None 8eb2 N O 0 G protein NA hla-a*02 IMMUNE SYSTEM 11/30/22 Structure of HLA-A*02:01 in complex with NY-ESO-1 peptide and PA2.1 Fab Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Jette, C.J., West, A.P. 2.9 X-RAY DIFFRACTION 0.284 0.239 False True IGHV1 IGKV1 Kappa None None None None None 7t17 J K 0 C protein NA core protein VIRUS 11/23/22 Zika Virus asymmetric unit bound with IgM antibody DH1017 Fab fragment Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Miller, A.S., Kuhn, R.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7t17 F G 0 A protein NA core protein VIRUS 11/23/22 Zika Virus asymmetric unit bound with IgM antibody DH1017 Fab fragment Homo sapiens; Zika virus homo sapiens homo sapiens zika virus Miller, A.S., Kuhn, R.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7stg B NA 0 A protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg D NA 0 C protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg F NA 0 E protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg H NA 0 G protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg J NA 0 I protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg L NA 0 K protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg N NA 0 M protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg P NA 0 O protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg R NA 0 Q protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg T NA 0 S protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg V NA 0 U protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg X NA 0 W protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg Z NA 0 Y protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False True IGHV1 NA NA None None None None None 7stg b NA 0 a protein NA unknown IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False False IGHV1 NA NA None None None None None 7stg d NA 0 c protein NA unknown IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False False IGHV1 NA NA None None None None None 7stg f NA 0 e protein NA unknown IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.7 X-RAY DIFFRACTION 0.276 0.242 False False IGHV1 NA NA None None None None None 7ssh B NA 0 A protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh D NA 0 C protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh F NA 0 E protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh H NA 0 G protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh J NA 0 I protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh L NA 0 K protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh N NA 0 M protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh P NA 0 O protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh R NA 0 Q protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh T NA 0 S protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh V NA 0 U protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh X NA 0 W protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh Z NA 0 Y protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False True IGHV1 NA NA None None None None None 7ssh b NA 0 a protein NA unknown IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False False IGHV1 NA NA None None None None None 7ssh d NA 0 c protein NA unknown IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False False IGHV1 NA NA None None None None None 7ssh f NA 0 e protein NA unknown IMMUNE SYSTEM 01/08/09 Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.73 X-RAY DIFFRACTION 0.294 0.253 False False IGHV1 NA NA None None None None None 7st3 B NA 0 A protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 D NA 0 C protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 F NA 0 E protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 H NA 0 G protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 J NA 0 I protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 L NA 0 K protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 N NA 0 M protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 P NA 0 O protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 R NA 0 Q protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 T NA 0 S protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 V NA 0 U protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 X NA 0 W protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 Z NA 0 Y protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False True IGHV1 NA NA None None None None None 7st3 b NA 0 a protein NA unknown IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False False IGHV1 NA NA None None None None None 7st3 d NA 0 c protein NA unknown IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False False IGHV1 NA NA None None None None None 7st3 f NA 0 e protein NA unknown IMMUNE SYSTEM/VIRAL PROTEIN 01/08/09 Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.78 X-RAY DIFFRACTION 0.275 0.238 False False IGHV1 NA NA None None None None None 7uvl H L 0 NA NA NA NA IMMUNE SYSTEM 01/08/09 IgA1 Protease with IgA1 substrate Gemella haemolysans; Homo sapiens homo sapiens homo sapiens Eisenmesser, Z.E., Zheng, H. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7sqp B NA 0 A protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (Y108C) with HPV.16 E7 peptide YMLDLQPETTDL Homo sapiens; Human papillomavirus type 16; Pongo pygmaeus homo sapiens human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.53 X-RAY DIFFRACTION 0.260 0.239 False True IGHV1 NA NA None None None None None 7sqp D NA 0 C protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (Y108C) with HPV.16 E7 peptide YMLDLQPETTDL Homo sapiens; Human papillomavirus type 16; Pongo pygmaeus homo sapiens human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.53 X-RAY DIFFRACTION 0.260 0.239 False True IGHV1 NA NA None None None None None 7sr0 B NA 0 A protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPET Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.54 X-RAY DIFFRACTION 0.242 0.217 False True IGHV1 NA NA None None None None None 7sr0 D NA 0 C protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPET Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.54 X-RAY DIFFRACTION 0.242 0.217 False True IGHV1 NA NA None None None None None 7sr3 B NA 0 A protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDL Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.49 X-RAY DIFFRACTION 0.248 0.225 False True IGHV1 NA NA None None None None None 7sr3 D NA 0 C protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDL Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.49 X-RAY DIFFRACTION 0.248 0.225 False True IGHV1 NA NA None None None None None 7sr4 B NA 0 A protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.59 X-RAY DIFFRACTION 0.247 0.218 False True IGHV1 NA NA None None None None None 7sr4 D NA 0 C protein NA protein e7 peptide,beta-2-microglobulin,mhc class i antigenchimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDLYC Homo sapiens; Human papillomavirus type 16; Lama glama; Pongo pygmaeus lama glama human papillomavirus type 16, pongo pygmaeus,homo sapiens Finton, K.A.K., Rupert, P.B. 2.59 X-RAY DIFFRACTION 0.247 0.218 False True IGHV1 NA NA None None None None None 7sr5 B NA 0 A protein NA wilms tumor protein peptide,beta-2-microglobulin,mhc classi antigen chimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (Y108C, A163C) with Wilms tumor protein peptide RMFPNAPYL Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.35 X-RAY DIFFRACTION 0.248 0.229 False True IGHV1 NA NA None None None None None 7sr5 D NA 0 C protein NA wilms tumor protein peptide,beta-2-microglobulin,mhc classi antigen chimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*02:01 (Y108C, A163C) with Wilms tumor protein peptide RMFPNAPYL Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.35 X-RAY DIFFRACTION 0.248 0.229 False True IGHV1 NA NA None None None None None 7srk B NA 0 A protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*24:02 (Y108C, A163C) with 8mer peptide YPPVPETF Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.5 X-RAY DIFFRACTION 0.260 0.229 False True IGHV1 NA NA None None None None None 7srk D NA 0 C protein NA rpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera IMMUNE SYSTEM 11/23/22 Single chain trimer HLA-A*24:02 (Y108C, A163C) with 8mer peptide YPPVPETF Homo sapiens; Lama glama; Pongo pygmaeus lama glama homo sapiens, pongo pygmaeus Finton, K.A.K., Rupert, P.B. 2.5 X-RAY DIFFRACTION 0.260 0.229 False True IGHV1 NA NA None None None None None 7sww H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/23/22 SARS-CoV-2 Spike NTD in complex with neutralizing Fab SARS2-57 (local refinement) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 0 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV8 Kappa None None None None None 7swx H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/23/22 SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-57 (three down conformation) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 0 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV8 Kappa None None None None None 7tjc A NA 0 A Hapten CLM CHLORAMPHENICOL IMMUNE SYSTEM 11/23/22 VHH Chl-B2 in complex with Chloramphenicol Vicugna pacos vicugna pacos vicugna pacos Nordeen, S.A., Schwartz, T.U. 1.35 X-RAY DIFFRACTION 0.235 0.200 False True IGHV1 NA NA None None None None None 7tjc B NA 0 B Hapten CLM CHLORAMPHENICOL IMMUNE SYSTEM 11/23/22 VHH Chl-B2 in complex with Chloramphenicol Vicugna pacos vicugna pacos vicugna pacos Nordeen, S.A., Schwartz, T.U. 1.35 X-RAY DIFFRACTION 0.235 0.200 False True IGHV1 NA NA None None None None None 7tr4 L H 0 A | P protein | peptide NA | NA hla-a*02 | melanoma antigen recognized by t-cells 1 IMMUNE SYSTEM 11/23/22 MA2-MART1-HLAA0201 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Yang, X., Jude, K.M., Garcia, K.C. 2.3 X-RAY DIFFRACTION 0.267 0.223 False True IGHV3 IGLV2 Lambda None None None None None 7u9o H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/23/22 SARS-CoV-2 spike trimer RBD in complex with Fab NE12 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tsybovsky, Y., Kwong, P.D., Farci, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7u9p H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/23/22 SARS-CoV-2 spike trimer RBD in complex with Fab NA8 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tsybovsky, Y., Kwong, P.D., Farci, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7umm H L 0 A protein NA hemagglutinin VIRAL PROTEIN 11/23/22 H1 Solomon Islands 2006 hemagglutinin in complex with Ab109 Influenza A virus (A/Solomon Islands/3/2006(H1N1)); Mus musculus mus musculus mus musculus influenza a virus (a/solomonislands/3/2006(h1n1)) Windsor, I.W., Caradonna, T.M., Schmidt, A.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7umm I M 0 B protein NA hemagglutinin VIRAL PROTEIN 11/23/22 H1 Solomon Islands 2006 hemagglutinin in complex with Ab109 Influenza A virus (A/Solomon Islands/3/2006(H1N1)); Mus musculus mus musculus mus musculus influenza a virus (a/solomonislands/3/2006(h1n1)) Windsor, I.W., Caradonna, T.M., Schmidt, A.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7umm J N 0 C protein NA hemagglutinin VIRAL PROTEIN 11/23/22 H1 Solomon Islands 2006 hemagglutinin in complex with Ab109 Influenza A virus (A/Solomon Islands/3/2006(H1N1)); Mus musculus mus musculus mus musculus influenza a virus (a/solomonislands/3/2006(h1n1)) Windsor, I.W., Caradonna, T.M., Schmidt, A.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uny B NA 0 D protein NA cysteine-rich small secreted protein css CELL INVASION 11/23/22 Crystal structure of D2 nanobody in complex with PfCSS Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Scally, S.W., Lim, P.S., Cowman, A.F. 4.13 X-RAY DIFFRACTION 0.249 0.216 False True IGHV1 NA NA None None None None None 7uny C NA 0 A protein NA cysteine-rich small secreted protein css CELL INVASION 11/23/22 Crystal structure of D2 nanobody in complex with PfCSS Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Scally, S.W., Lim, P.S., Cowman, A.F. 4.13 X-RAY DIFFRACTION 0.249 0.216 False True IGHV1 NA NA None None None None None 7unz C NA 0 B protein NA cysteine-rich small secreted protein css, putative CELL INVASION 11/23/22 Crystal structure of H2 nanobody in complex with PfCSS Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Scally, S.W., Cowman, A.F. 2.03 X-RAY DIFFRACTION 0.217 0.185 False True IGHV1 NA NA None None None None None 7unz A NA 0 D protein NA cysteine-rich small secreted protein css, putative CELL INVASION 11/23/22 Crystal structure of H2 nanobody in complex with PfCSS Plasmodium falciparum; Vicugna pacos vicugna pacos plasmodium falciparum Scally, S.W., Cowman, A.F. 2.03 X-RAY DIFFRACTION 0.217 0.185 False True IGHV1 NA NA None None None None None 7uyl H L 0 NA NA NA NA ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM 11/23/22 850 Fab Lama glama; Mus musculus mus musculus mus musculus Kucharska, I., Prieto, K., Julien, J.P. 2 X-RAY DIFFRACTION 0.212 0.174 False True IGHV3 IGKV1 Kappa None None None None None 7uyl K NA 0 NA NA NA NA ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM 11/23/22 850 Fab Lama glama; Mus musculus lama glama Kucharska, I., Prieto, K., Julien, J.P. 2 X-RAY DIFFRACTION 0.212 0.174 False True unknown unknown unknown None None None None None 7uym H L 0 P peptide NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM 11/23/22 850 Fab in complex with NANPNANPNANP peptide Lama glama; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.216 0.169 False True IGHV3 IGKV1 Kappa None None None None None 7uym K NA 0 NA NA NA NA ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM 11/23/22 850 Fab in complex with NANPNANPNANP peptide Lama glama; Mus musculus; SYNTHETIC CONSTRUCT lama glama Kucharska, I., Prieto, K., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.216 0.169 False True unknown unknown unknown None None None None None 7v05 A a 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 B b 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 C c 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 D d 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 E e 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 F f 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 G g 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 H h 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 I i 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 J j 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 K k 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 L l 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 M m 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v05 N n 0 X protein NA circumsporozoite protein ANTIMICROBIAL PROTEIN,IMMUNE SYSTEM/CELL INVASION 11/23/22 Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Kucharska, I., Prieto, K., Rubinstein, J.L., Julien, J.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7wki B NA 0 A protein NA complement factor h IMMUNE SYSTEM 11/23/22 Structure of the ultra-affinity complex between CFH and a nanobody Homo sapiens; Vicugna pacos vicugna pacos homo sapiens Caaveiro, J.M.M., Yokoo, T., Tsumoto, K. 2.6 X-RAY DIFFRACTION 0.239 0.192 False True IGHV1 NA NA None None None None None 7xmx E F 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three F61 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xmx H I 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three F61 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xmx K L 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three F61 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.62 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xmz H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xmz D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xmz G I 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xst L M 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 Omicron spike glycoprotein in complex with three F61 Fab and three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xst N O 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 Omicron spike glycoprotein in complex with three F61 Fab and three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xst H I 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 Omicron spike glycoprotein in complex with three F61 Fab and three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xst J K 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 Omicron spike glycoprotein in complex with three F61 Fab and three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xst D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 Omicron spike glycoprotein in complex with three F61 Fab and three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xst F G 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/23/22 Cryo-EM structure of SARS-CoV-2 Omicron spike glycoprotein in complex with three F61 Fab and three D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Li, X. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xy8 H L 0 A protein NA isoform 2 of basigin PROTEIN BINDING 11/23/22 Crystal structure of antibody Fab fragment in complex with CD147(EMMPIRIN) Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Nakamura, K., Amano, M., Yoneda, K., Suzuki, M., Fukuchi, K. 2.3 X-RAY DIFFRACTION 0.281 0.236 False True IGHV1 IGKV1 Kappa None None None None None 7xy8 I M 0 B protein NA isoform 2 of basigin PROTEIN BINDING 11/23/22 Crystal structure of antibody Fab fragment in complex with CD147(EMMPIRIN) Homo sapiens; synthetic construct synthetic construct synthetic construct homo sapiens Nakamura, K., Amano, M., Yoneda, K., Suzuki, M., Fukuchi, K. 2.3 X-RAY DIFFRACTION 0.281 0.236 False True IGHV1 IGKV1 Kappa None None None None None 8as0 B C 0 A protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8as0 E D 0 F protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8as0 H G 0 I protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8as0 K J 0 L protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8as0 N M 0 O protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8as0 Q P 0 R protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8as0 W V 0 X protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8as0 T S 0 Y protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 11/23/22 PD-1 extracellular domain in complex with Fab fragment from D12 antibody Homo sapiens homo sapiens homo sapiens homo sapiens Ongaro, T., Scietti, L., Pluss, L., Peissert, F., Villa, A., Puca, E., De Luca, R., Neri, D., Forneris, F. 3.5 X-RAY DIFFRACTION 0.293 0.243 False True IGHV3 IGKV1 Kappa None None None None None 8bh5 H L 0 E protein NA spike protein s1 IMMUNE SYSTEM 11/23/22 SARS-CoV-2 BA.2.12.1 RBD in complex with Beta-27 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huo, J., Zhou, D., Ren, J., Stuart, D.I. 2.38 X-RAY DIFFRACTION 0.233 0.186 False True IGHV3 IGKV3 Kappa None None None None None 8bh5 C NA 0 E protein NA spike protein s1 IMMUNE SYSTEM 11/23/22 SARS-CoV-2 BA.2.12.1 RBD in complex with Beta-27 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huo, J., Zhou, D., Ren, J., Stuart, D.I. 2.38 X-RAY DIFFRACTION 0.233 0.186 False True IGHV1 NA NA None None None None None 8dtr A B 0 G peptide NA spike protein s2' stem helix peptide IMMUNE SYSTEM 11/23/22 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV30-14 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Wilson, I.A. 1.5 X-RAY DIFFRACTION 0.222 0.198 False True IGHV1 IGKV3 Kappa None None None None None 8dtr E F 0 J peptide NA spike protein s2' stem helix peptide IMMUNE SYSTEM 11/23/22 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV30-14 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Wilson, I.A. 1.5 X-RAY DIFFRACTION 0.222 0.198 False True IGHV1 IGKV3 Kappa None None None None None 8dtt A B 0 G peptide NA spike protein s2' stem helix peptide IMMUNE SYSTEM 11/23/22 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV93-03 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.225 0.195 False True IGHV1 IGKV3 Kappa None None None None None 8dtt E F 0 J peptide NA spike protein s2' stem helix peptide IMMUNE SYSTEM 11/23/22 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV93-03 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.225 0.195 False True IGHV1 IGKV3 Kappa None None None None None 8dtx H L 0 I peptide NA spike protein s2' stem helix peptide IMMUNE SYSTEM 11/23/22 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV89-22 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lin, T.H., Lee, C.C.D., Wilson, I.A. 1.6 X-RAY DIFFRACTION 0.210 0.185 False True IGHV1 IGKV3 Kappa None None None None None 8dtx A B 0 G peptide NA spike protein s2' stem helix peptide IMMUNE SYSTEM 11/23/22 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV89-22 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lin, T.H., Lee, C.C.D., Wilson, I.A. 1.6 X-RAY DIFFRACTION 0.210 0.185 False True IGHV1 IGKV3 Kappa None None None None None 8e3x N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 11/23/22 Cryo-EM structure of the PAC1R-PACAP27-Gs complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Piper, S.J., Danev, R., Sexton, P., Wootten, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8e3y N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/23/22 Cryo-EM structure of the VPAC1R-PACAP27-Gs complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Piper, S.J., Danev, R., Sexton, P., Wootten, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8e3z N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/23/22 Cryo-EM structure of the VPAC1R-VIP-Gs complex Homo sapiens; Lama glama; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Piper, S.J., Danev, R., Sexton, P., Wootten, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8ew6 V NA 0 W protein NA t-cell surface glycoprotein cd8 alpha chain IMMUNE SYSTEM 11/23/22 Anti-human CD8 VHH complex with CD8 alpha Homo sapiens; Lama glama lama glama homo sapiens Kiefer, J.R., Williams, S., Davies, C.W., Koerber, J.T., Sriraman, S.K., Yin, Y.P. 1.904 X-RAY DIFFRACTION 0.245 0.200 False True IGHV1 NA NA None None None None None 8d5c H L 0 A | D protein | protein NA | NA envelope glycoprotein gp160 | t-cell surface glycoprotein cd4 VIRAL PROTEIN/Immune System 11/16/22 anti-HIV-1 gp120-sCD4 complex antibody CG10 Fab in complex with B41-sCD4 Homo sapiens; Human immunodeficiency virus; Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus | homo sapiens Yang, Z., Bjorkman, P.J., Gershoni, J.M. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8d5c I J 0 B | E protein | protein NA | NA envelope glycoprotein gp160 | t-cell surface glycoprotein cd4 VIRAL PROTEIN/Immune System 11/16/22 anti-HIV-1 gp120-sCD4 complex antibody CG10 Fab in complex with B41-sCD4 Homo sapiens; Human immunodeficiency virus; Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus | homo sapiens Yang, Z., Bjorkman, P.J., Gershoni, J.M. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8d5c P Q 0 C | F protein | protein NA | NA envelope glycoprotein gp160 | t-cell surface glycoprotein cd4 VIRAL PROTEIN/Immune System 11/16/22 anti-HIV-1 gp120-sCD4 complex antibody CG10 Fab in complex with B41-sCD4 Homo sapiens; Human immunodeficiency virus; Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus | homo sapiens Yang, Z., Bjorkman, P.J., Gershoni, J.M. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dvd H L 0 G | E | F protein | protein | protein NA | NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 01/08/09 Cryo-EM structure of SIVmac239 SOS-2P Env trimer in complex with human bNAb PGT145 Homo sapiens; Simian immunodeficiency virus homo sapiens homo sapiens simian immunodeficiency virus | simian immunodeficiency virus | simian immunodeficiency virus Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 7pa5 B NA 0 A protein NA beta-lactamase HYDROLASE 11/16/22 Complex between the beta-lactamase CMY-2 with an inhibitory nanobody Camelidae; Escherichia coli camelidae escherichia coli Frederic Cawez, F.C., Frederic Kerff, F.K., Moreno Galleni, M.G., Raphael Herman, R.H. 3.184 X-RAY DIFFRACTION 0.250 0.207 False True IGHV3 NA NA None None None None None 7q3q B NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/16/22 Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing nanobody VHH-12 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Fernandez, I., Pederzoli, R., Rey, F.A. 2.3 X-RAY DIFFRACTION 0.220 0.185 False True IGHV1 NA NA None None None None None 7q3r F NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/16/22 Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing nanobodies VHH-F04 and VHH-G09 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Fernandez, I., Pederzoli, R., Rey, F.A. 1.92 X-RAY DIFFRACTION 0.209 0.182 False True IGHV1 NA NA None None None None None 7q3r G NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/16/22 Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing nanobodies VHH-F04 and VHH-G09 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Fernandez, I., Pederzoli, R., Rey, F.A. 1.92 X-RAY DIFFRACTION 0.209 0.182 False True IGHV1 NA NA None None None None None 7r58 H L 0 A protein NA platelet glycoprotein vi BLOOD CLOTTING 11/16/22 Crystal structure of the GPVI-glenzocimab complex Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jandrot-Perrus, M., Lebozec, K., Rose, N., Welin, M., Billiald, P. 1.902 X-RAY DIFFRACTION 0.232 0.186 False True IGHV1 IGKV1 Kappa None None None None None 7sj0 B L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/16/22 Antibody A7V3 bound to N-terminal domain of the spike Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7ubx D NA 0 A protein NA toxin a TOXIN 11/16/22 Structure of a pore forming fragment of Clostridium difficile toxin A in complex with VHH AA6 Camelidae; Clostridioides difficile camelidae clostridioides difficile Baohua, C., Rongsheng, J., Kay, P. 1.81 X-RAY DIFFRACTION 0.246 0.213 False True IGHV5 NA NA None None None None None 7ubx C NA 0 B protein NA toxin a TOXIN 11/16/22 Structure of a pore forming fragment of Clostridium difficile toxin A in complex with VHH AA6 Camelidae; Clostridioides difficile camelidae clostridioides difficile Baohua, C., Rongsheng, J., Kay, P. 1.81 X-RAY DIFFRACTION 0.246 0.213 False True IGHV5 NA NA None None None None None 7uby D NA 0 B protein NA glucosyltransferase tcda TOXIN 11/16/22 Structure of the GTD domain of Clostridium difficile toxin A in complex with VHH AH3 Camelidae; Clostridioides difficile camelidae clostridioides difficile Baohua, C., Rongsheng, J., Kay, P. 2.1 X-RAY DIFFRACTION 0.261 0.218 False True IGHV1 NA NA None None None None None 7uby C NA 0 A protein NA glucosyltransferase tcda TOXIN 11/16/22 Structure of the GTD domain of Clostridium difficile toxin A in complex with VHH AH3 Camelidae; Clostridioides difficile camelidae clostridioides difficile Baohua, C., Rongsheng, J., Kay, P. 2.1 X-RAY DIFFRACTION 0.261 0.218 False True IGHV1 NA NA None None None None None 7wvf C c 0 A protein NA toll-like receptor 3 IMMUNE SYSTEM/RNA 11/16/22 ectoTLR3-mAb12-poly(I:C) complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Lim, C.S., Jang, Y.H., Lee, G.Y., Han, G.M., Lee, J.O. 3.91 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7zw1 C NA 0 B protein NA rod outer segment membrane protein 1 MEMBRANE PROTEIN 11/16/22 Human PRPH2-ROM1 hetero-dimer Homo sapiens; Lama lama homo sapiens El Mazouni, D., Gros, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dim B C 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/16/22 CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8dim E F 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/16/22 CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8dim H I 0 G protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/16/22 CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8dyp B NA 0 A protein NA cystinosin TRANSPORT PROTEIN 11/16/22 Crystal structure of human cystine transporter cystinosin Homo sapiens; synthetic construct synthetic construct homo sapiens Guo, X., Feng, L. 3.4 X-RAY DIFFRACTION 0.302 0.270 False True IGHV1 NA NA None None None None None 8ema A R 0 NA NA NA NA IMMUNE SYSTEM 11/16/22 mouse full length B cell receptor Aliivibrio fischeri; Mus musculus mus musculus mus musculus Ying, D., Xiong, P., Michael, R. 8.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8ema B L 0 NA NA NA NA IMMUNE SYSTEM 11/16/22 mouse full length B cell receptor Aliivibrio fischeri; Mus musculus mus musculus mus musculus Ying, D., Xiong, P., Michael, R. 8.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7s07 X Y 0 A | B protein | protein NA | NA envelope glycoprotein h | envelope glycoprotein l IMMUNE SYSTEM/VIRAL PROTEIN 11/09/22 Crystal structure of Epstein-Barr virus glycoprotein gH/gL/gp42-peptide in complex with human neutralizing antibodies 769B10 and 769C2 Homo sapiens; Human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 | human gammaherpesvirus 4 Chen, W.-H., Kanekiyo, M., Cohen, J.I., Joyce, M.G. 3.29 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGLV2 Lambda None None None None None 7s07 H L 0 A protein NA envelope glycoprotein h IMMUNE SYSTEM/VIRAL PROTEIN 11/09/22 Crystal structure of Epstein-Barr virus glycoprotein gH/gL/gp42-peptide in complex with human neutralizing antibodies 769B10 and 769C2 Homo sapiens; Human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Chen, W.-H., Kanekiyo, M., Cohen, J.I., Joyce, M.G. 3.29 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 7s1b H L 0 A protein NA envelope glycoprotein h IMMUNE SYSTEM 11/09/22 Crystal structure of Epstein-Barr virus glycoproteins gH/gL/gp42-peptide in complex with human neutralizing antibodies 769C2 and 770F7 Homo sapiens; Human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 Chen, W.-H., Cohen, J.I., Kanekiyo, M., Joyce, M.G. 3.03 X-RAY DIFFRACTION 0.288 0.241 False True IGHV4 IGKV3 Kappa None None None None None 7s1b X Y 0 A | B protein | protein NA | NA envelope glycoprotein h | envelope glycoprotein l IMMUNE SYSTEM 11/09/22 Crystal structure of Epstein-Barr virus glycoproteins gH/gL/gp42-peptide in complex with human neutralizing antibodies 769C2 and 770F7 Homo sapiens; Human gammaherpesvirus 4 homo sapiens homo sapiens human gammaherpesvirus 4 | human gammaherpesvirus 4 Chen, W.-H., Cohen, J.I., Kanekiyo, M., Joyce, M.G. 3.03 X-RAY DIFFRACTION 0.288 0.241 False True IGHV3 IGLV2 Lambda None None None None None 7sd3 G H 0 F | E protein | protein NA | NA transmembrane protein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cytoplasmic tail deleted HIV-1 Env bound with three 4E10 Fabs HIV whole-genome vector AA1305#18; Homo sapiens homo sapiens homo sapiens hiv whole-genome vector aa1305#18 | hiv whole-genome vector aa1305#18 Yang, S., Walz, T. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sd3 K N 0 B protein NA transmembrane protein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cytoplasmic tail deleted HIV-1 Env bound with three 4E10 Fabs HIV whole-genome vector AA1305#18; Homo sapiens homo sapiens homo sapiens hiv whole-genome vector aa1305#18 Yang, S., Walz, T. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sd3 I M 0 D protein NA transmembrane protein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cytoplasmic tail deleted HIV-1 Env bound with three 4E10 Fabs HIV whole-genome vector AA1305#18; Homo sapiens homo sapiens homo sapiens hiv whole-genome vector aa1305#18 Yang, S., Walz, T. 3.67 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7myt A B 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal Structure of HPV L1-directed B25.M05 Fab Homo sapiens homo sapiens homo sapiens Singh, S., Pancera, M. 2.1 X-RAY DIFFRACTION 0.223 0.173 False True IGHV4 IGLV2 Lambda None None None None None 7myt H L 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal Structure of HPV L1-directed B25.M05 Fab Homo sapiens homo sapiens homo sapiens Singh, S., Pancera, M. 2.1 X-RAY DIFFRACTION 0.223 0.173 False True IGHV4 IGLV2 Lambda None None None None None 7s08 H L 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal structure of Epstein-Barr virus gH/gL targeting antibody 770F7 Homo sapiens homo sapiens homo sapiens Chen, W.-H., Joyce, M.G. 2.42 X-RAY DIFFRACTION 0.260 0.212 False True IGHV4 IGKV3 Kappa None None None None None 7s08 A B 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal structure of Epstein-Barr virus gH/gL targeting antibody 770F7 Homo sapiens homo sapiens homo sapiens Chen, W.-H., Joyce, M.G. 2.42 X-RAY DIFFRACTION 0.260 0.212 False True IGHV4 IGKV3 Kappa None None None None None 7s0j H L 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal structure of Epstein-Barr virus gH/gL targeting antibody 769B10 Homo sapiens homo sapiens homo sapiens Chen, W.-H., Kanekiyo, M., Cohen, J.I., Joyce, M.G. 2.15 X-RAY DIFFRACTION 0.262 0.235 False True IGHV3 IGKV1 Kappa None None None None None 7try H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein subunit alpha-11 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/09/22 Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein Homo sapiens; Rattus norvegicus; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhao, L.-H., Lin, J., Mao, C., Zhou, X.E., Ji, S., Shen, D., Xiao, P., Melcher, K., Zhang, Y., Yu, X., Xu, H.E. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ugm H L 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal Structure of BG24-iGL CDR3mat Fab Homo sapiens homo sapiens homo sapiens Dam, K.A., Barnes, C.O., Bjorkman, P.J. 1.4 X-RAY DIFFRACTION 0.208 0.193 False True IGHV1 IGLV2 Lambda None None None None None 7ugp M P 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugp N Q 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugp O R 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugp G J 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugp H K 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugp I L 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugq G J 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline CDRL1 and 10-1074 Fabs in complex with HIV-1 Env 6405-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugq H K 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline CDRL1 and 10-1074 Fabs in complex with HIV-1 Env 6405-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugq I L 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline CDRL1 and 10-1074 Fabs in complex with HIV-1 Env 6405-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugq M P 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline CDRL1 and 10-1074 Fabs in complex with HIV-1 Env 6405-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugq N Q 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline CDRL1 and 10-1074 Fabs in complex with HIV-1 Env 6405-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugq O R 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/09/22 Cryo-EM structure of BG24 Fabs with an inferred germline CDRL1 and 10-1074 Fabs in complex with HIV-1 Env 6405-SOSIP.664 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7wg3 E A 0 I protein NA il17rb protein IMMUNE SYSTEM 11/09/22 Structural basis of interleukin-17B receptor in complex with a neutralizing antibody D9 for guiding humanization and affinity maturation for cancer therapy Bos taurus; Mus musculus mus musculus mus musculus bos taurus Lee, W.H., Chen, X.R., Liu, I.J., Lee, J.H., Hu, C.M., Wu, H.C., Wang, S.K., Lee, W.H., Ma, C. 2.19 X-RAY DIFFRACTION 0.238 0.193 False True IGHV1 IGKV4 Kappa None None None None None 7wg3 F B 0 J protein NA il17rb protein IMMUNE SYSTEM 11/09/22 Structural basis of interleukin-17B receptor in complex with a neutralizing antibody D9 for guiding humanization and affinity maturation for cancer therapy Bos taurus; Mus musculus mus musculus mus musculus bos taurus Lee, W.H., Chen, X.R., Liu, I.J., Lee, J.H., Hu, C.M., Wu, H.C., Wang, S.K., Lee, W.H., Ma, C. 2.19 X-RAY DIFFRACTION 0.238 0.193 False True IGHV1 IGKV4 Kappa None None None None None 7wg3 G C 0 K protein NA il17rb protein IMMUNE SYSTEM 11/09/22 Structural basis of interleukin-17B receptor in complex with a neutralizing antibody D9 for guiding humanization and affinity maturation for cancer therapy Bos taurus; Mus musculus mus musculus mus musculus bos taurus Lee, W.H., Chen, X.R., Liu, I.J., Lee, J.H., Hu, C.M., Wu, H.C., Wang, S.K., Lee, W.H., Ma, C. 2.19 X-RAY DIFFRACTION 0.238 0.193 False True IGHV1 IGKV4 Kappa None None None None None 7wg3 H D 0 L protein NA il17rb protein IMMUNE SYSTEM 11/09/22 Structural basis of interleukin-17B receptor in complex with a neutralizing antibody D9 for guiding humanization and affinity maturation for cancer therapy Bos taurus; Mus musculus mus musculus mus musculus bos taurus Lee, W.H., Chen, X.R., Liu, I.J., Lee, J.H., Hu, C.M., Wu, H.C., Wang, S.K., Lee, W.H., Ma, C. 2.19 X-RAY DIFFRACTION 0.238 0.193 False True IGHV1 IGKV4 Kappa None None None None None 7x10 E e 0 A | B protein | protein NA | NA engineered g alpha 12 subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/09/22 ADGRL3/miniG12 complex Homo sapiens; Mus musculus homo sapiens homo sapiens | homo sapiens He, Y., Qian, Y. 2.93 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7x26 H K 0 I protein NA spike glycoprotein IMMUNE SYSTEM 11/09/22 S41 neutralizing antibody Fab(MERS-CoV) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zeng, J.W., Zhang, S.Y., Wang, X.W. 3.685 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x29 F G 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/09/22 MERS-CoV spike complex with S41 neutralizing antibody Fab Class2 (1u2d RBD with 2Fab) Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x29 H K 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/09/22 MERS-CoV spike complex with S41 neutralizing antibody Fab Class2 (1u2d RBD with 2Fab) Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x2a H K 0 A protein NA mers-cov spike glycoprotein VIRAL PROTEIN 11/09/22 MERS-CoV spike complex with S41 neutralizing antibody Fab Class1 (1u2d RBD with 1Fab) Homo sapiens; Middle East respiratory syndrome-related coronavirus homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Zeng, J.W., Zhang, S.Y., Zhou, H.X., Wang, X.W. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7xl0 A NA 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal structure of Vobarilizumab at 1.70 Angstrom Lama glama lama glama Caaveiro, J.M.M., Mori, C., Kinoshita, S., Nakakido, M., Tsumoto, K. 1.7 X-RAY DIFFRACTION 0.196 0.152 False True IGHV3 NA NA None None None None None 7xl0 B NA 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal structure of Vobarilizumab at 1.70 Angstrom Lama glama lama glama Caaveiro, J.M.M., Mori, C., Kinoshita, S., Nakakido, M., Tsumoto, K. 1.7 X-RAY DIFFRACTION 0.196 0.152 False True IGHV3 NA NA None None None None None 7xl1 A NA 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal structure of chimeric 7D12-Vob nanobody at 1.65 Angstrom Lama glama lama glama Caaveiro, J.M.M., Kinoshita, S., Mori, C., Nakakido, M., Tsumoto, K. 1.65 X-RAY DIFFRACTION 0.206 0.156 False True IGHV1 NA NA None None None None None 7xl1 B NA 0 NA NA NA NA IMMUNE SYSTEM 11/09/22 Crystal structure of chimeric 7D12-Vob nanobody at 1.65 Angstrom Lama glama lama glama Caaveiro, J.M.M., Kinoshita, S., Mori, C., Nakakido, M., Tsumoto, K. 1.65 X-RAY DIFFRACTION 0.206 0.156 False True IGHV1 NA NA None None None None None 8ef5 E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/09/22 Fentanyl-bound mu-opioid receptor-Gi complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | bos taurus | rattus norvegicus Zhuang, Y., Wang, Y., Guo, S., Zhou, X.E., Rao, Q., He, X., He, B., Liu, J., Zhou, Q., Wang, X., Liu, W., Jiang, X., Yang, D., Chen, X., Jiang, Y., Jiang, H., Shen, J., Melcher, K., Wang, M., Xie, X., Xu, H.E. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ef6 E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/09/22 Morphine-bound mu-opioid receptor-Gi complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | bos taurus | rattus norvegicus Zhuang, Y., Wang, Y., Guo, S., Zhou, X.E., Rao, Q., He, X., He, B., Liu, J., Zhou, Q., Wang, X., Liu, W., Jiang, X., Yang, D., Chen, X., Jiang, Y., Jiang, H., Shen, J., Melcher, K., Wang, M., Xie, X., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8efb E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/09/22 Oliceridine-bound mu-opioid receptor-Gi complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | bos taurus | rattus norvegicus Zhuang, Y., Wang, Y., Guo, S., Zhou, X.E., Rao, Q., He, X., He, B., Liu, J., Zhou, Q., Wang, X., Liu, W., Jiang, X., Yang, D., Chen, X., Jiang, Y., Jiang, H., Shen, J., Melcher, K., Wang, M., Xie, X., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8efl E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/09/22 SR17018-bound mu-opioid receptor-Gi complex Homo sapiens; Rattus norvegicus homo sapiens homo sapiens | homo sapiens | rattus norvegicus Zhuang, Y., Wang, Y., Guo, S., Zhou, X.E., Rao, Q., He, X., He, B., Liu, J., Zhou, Q., Wang, X., Liu, W., Jiang, X., Yang, D., Chen, X., Jiang, Y., Jiang, H., Shen, J., Melcher, K., Wang, M., Xie, X., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8efo E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/09/22 PZM21-bound mu-opioid receptor-Gi complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct homo sapiens | bos taurus | rattus norvegicus Zhuang, Y., Wang, Y., Guo, S., Zhou, X.E., Rao, Q., He, X., He, B., Liu, J., Zhou, Q., Wang, X., Liu, W., Jiang, X., Yang, D., Chen, X., Jiang, Y., Jiang, H., Shen, J., Melcher, K., Wang, M., Xie, X., Xu, H.E. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7uot S T 0 c protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uot O P 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uot Q R 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uot H L 0 C | A | B protein | protein | protein NA | NA | NA glycoprotein g2 | glycoprotein g2 | glycoprotein g2 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus | lassa virus | lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 7zg0 G NA 0 C | F protein | protein NA | NA interleukin-27 subunit beta | interleukin-27 receptor subunit alpha CYTOKINE 11/02/22 Murine IL-27 in complex with IL-27Ra and a non-competing Nb Lama glama; Mus musculus lama glama mus musculus | mus musculus Skladanowska, K., Bloch, Y., Savvides, S.N. 3.18 X-RAY DIFFRACTION 0.278 0.229 False True IGHV1 NA NA None None None None None 7zg0 H NA 0 D | E protein | protein NA | NA interleukin-27 subunit beta | interleukin-27 receptor subunit alpha CYTOKINE 11/02/22 Murine IL-27 in complex with IL-27Ra and a non-competing Nb Lama glama; Mus musculus lama glama mus musculus | mus musculus Skladanowska, K., Bloch, Y., Savvides, S.N. 3.18 X-RAY DIFFRACTION 0.278 0.229 False True IGHV1 NA NA None None None None None 8gpu H L 0 A protein NA envelope protein ANTIVIRAL PROTEIN 01/08/09 YFV_E_YD6Fab_prefusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 2.79 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGLV2 Lambda None None None None None 8gpu F G 0 E protein NA envelope protein ANTIVIRAL PROTEIN 01/08/09 YFV_E_YD6Fab_prefusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 2.79 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGLV2 Lambda None None None None None 8gpu C D 0 B protein NA envelope protein ANTIVIRAL PROTEIN 01/08/09 YFV_E_YD6Fab_prefusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 2.79 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGLV2 Lambda None None None None None 8gpu J K 0 I protein NA envelope protein ANTIVIRAL PROTEIN 01/08/09 YFV_E_YD6Fab_prefusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 2.79 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGLV2 Lambda None None None None None 8gpu N O 0 M protein NA envelope protein ANTIVIRAL PROTEIN 01/08/09 YFV_E_YD6Fab_prefusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 2.79 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGLV2 Lambda None None None None None 8gpu Q R 0 P protein NA envelope protein ANTIVIRAL PROTEIN 01/08/09 YFV_E_YD6Fab_prefusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 2.79 X-RAY DIFFRACTION 0.279 0.244 False True IGHV3 IGLV2 Lambda None None None None None 7u5g H L 0 NA NA NA NA IMMUNE SYSTEM 11/02/22 ACS122 Fab Homo sapiens homo sapiens homo sapiens Farokhi, E., Stanfield, R.L., Wilson, I.A. 1.84 X-RAY DIFFRACTION 0.256 0.222 False True IGHV4 IGLV3 Lambda None None None None None 7uov H L 0 A protein NA glycoprotein g2 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7uov S T 0 c protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uov D E 0 B protein NA glycoprotein g2 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7uov O P 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7uov F G 0 C protein NA glycoprotein g2 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7uov Q R 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 11/02/22 Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D Homo sapiens; Lassa virus homo sapiens homo sapiens lassa virus Li, H., Saphire, E.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7vtj H L 0 C peptide NA vqiiyk peptide IMMUNE SYSTEM 11/02/22 The cross-reaction complex structure with VQIIYK peptide and tau antibody's Fab domain. Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Tsuchida, T., Fukuhara, N., Tsuchiya, T., Miyamoto, K., In, Y., Minoura, K., Taniguchi, Y., Ishida, T., Tomoo, K. 2 X-RAY DIFFRACTION 0.295 0.196 False False IGHV1 IGLV3 Lambda None None None None None 7z12 B C 0 A protein NA var2csa CELL ADHESION 11/02/22 VAR2 complex with PAM1.4 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Raghavan, S.S.R., Wang, K.T. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zxk H L 0 C protein NA interleukin-27 subunit alpha CYTOKINE 11/02/22 Human IL-27 in complex with neutralizing SRF388 FAb fragment Homo sapiens homo sapiens homo sapiens homo sapiens Bloch, Y., Skladanowska, K., Strand, J., Welin, M., Logan, D., Hill, J., Savvides, S.N. 2.2 X-RAY DIFFRACTION 0.221 0.184 False True IGHV3 IGKV4 Kappa None None None None None 7zxk J I 0 A protein NA interleukin-27 subunit alpha CYTOKINE 11/02/22 Human IL-27 in complex with neutralizing SRF388 FAb fragment Homo sapiens homo sapiens homo sapiens homo sapiens Bloch, Y., Skladanowska, K., Strand, J., Welin, M., Logan, D., Hill, J., Savvides, S.N. 2.2 X-RAY DIFFRACTION 0.221 0.184 False True IGHV3 IGKV4 Kappa None None None None None 8dwc E e 0 B | C protein | protein NA | NA gs-mini-gq chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/02/22 CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 Bos taurus; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Liu, Y., Cao, C., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dwg E e 0 B | C protein | protein NA | NA gs-mini-gq chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/02/22 CryoEM structure of Gq-coupled MRGPRX1 with peptide ligand BAM8-22 and positive allosteric modulator ML382 Bos taurus; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Liu, Y., Cao, C., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8gpt D E 0 A protein NA envelope protein ANTIVIRAL PROTEIN 11/02/22 YFV_E_YD6scFv_postfusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 3.07 X-RAY DIFFRACTION 0.247 0.211 False True IGHV3 IGLV2 Lambda None None None None None 8gpt F G 0 B protein NA envelope protein ANTIVIRAL PROTEIN 11/02/22 YFV_E_YD6scFv_postfusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 3.07 X-RAY DIFFRACTION 0.247 0.211 False True IGHV3 IGLV2 Lambda None None None None None 8gpt H I 0 C protein NA envelope protein ANTIVIRAL PROTEIN 11/02/22 YFV_E_YD6scFv_postfusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Qi, J., Yan, J., Gao, G.F. 3.07 X-RAY DIFFRACTION 0.247 0.211 False True IGHV3 IGLV2 Lambda None None None None None 8gpx H L 0 E protein NA envelope protein ANTIVIRAL PROTEIN 11/02/22 YFV_E_YD73Fab_postfusion Homo sapiens; Yellow fever virus homo sapiens homo sapiens yellow fever virus Li, Y., Wu, L., Chai, Y., Qi, J., Yan, J., Gao, G.F. 3.8 X-RAY DIFFRACTION 0.306 0.261 False True IGHV1 IGKV3 Kappa None None None None None 8dua H L 0 B | G protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 SIV E660.CR54 SOS-2P Env Trimer with ITS92.02 Macaca mulatta; Simian immunodeficiency virus macaca mulatta macaca mulatta simian immunodeficiency virus | simian immunodeficiency virus Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dua D E 0 A | C protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 SIV E660.CR54 SOS-2P Env Trimer with ITS92.02 Macaca mulatta; Simian immunodeficiency virus macaca mulatta macaca mulatta simian immunodeficiency virus | simian immunodeficiency virus Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 8dua J K 0 F | I protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 SIV E660.CR54 SOS-2P Env Trimer with ITS92.02 Macaca mulatta; Simian immunodeficiency virus macaca mulatta macaca mulatta simian immunodeficiency virus | simian immunodeficiency virus Gorman, J., Kwong, P.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 7ocj G NA 0 A protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS2(Nb14509) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.7 X-RAY DIFFRACTION 0.260 0.228 False True IGHV1 NA NA None None None None None 7ocj E NA 0 C protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS2(Nb14509) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.7 X-RAY DIFFRACTION 0.260 0.228 False True IGHV1 NA NA None None None None None 7ocj B NA 0 D protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS2(Nb14509) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.7 X-RAY DIFFRACTION 0.260 0.228 False True IGHV1 NA NA None None None None None 7ocj H NA 0 F protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS2(Nb14509) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.7 X-RAY DIFFRACTION 0.260 0.228 False True IGHV1 NA NA None None None None None 7zra E NA 0 C protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS1(Nb14497) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.8 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 NA NA None None None None None 7zra G NA 0 A protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS1(Nb14497) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.8 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 NA NA None None None None None 7zra F NA 0 D protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS1(Nb14497) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.8 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 NA NA None None None None None 7zra H NA 0 B protein NA lexa repressor TRANSCRIPTION 01/08/09 Crystal structure of E.coli LexA in complex with nanobody NbSOS1(Nb14497) Escherichia coli; Lama glama lama glama escherichia coli Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.8 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 NA NA None None None None None 7u8g D E 0 A protein NA egfp, cytochrome b-245 heavy chain chimera OXIDOREDUCTASE 10/26/22 Cryo-EM structure of the core human NADPH oxidase NOX2 Homo sapiens; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus homo sapiens Noreng, S., Ota, N., Sun, Y., Masureel, M., Payandeh, J., Yi, T., Koerber, J.T. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7ugn G J 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugn H K 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugn I L 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugn M P 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugn N Q 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugn O R 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugo M P 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugo N Q 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugo O R 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7ugo G J 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugo H K 0 B protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ugo I L 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Dam, K.A., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7vn9 H L 0 E protein NA spike glycoprotein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with C04 Fab Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Xiang, J.C., Yang, B. 4.49 X-RAY DIFFRACTION 0.289 0.273 False True IGHV3 IGKV1 Kappa None None None None None 7vn9 A B 0 C protein NA spike glycoprotein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with C04 Fab Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Xiang, J.C., Yang, B. 4.49 X-RAY DIFFRACTION 0.289 0.273 False True IGHV3 IGKV1 Kappa None None None None None 7vng H L 0 D protein NA spike glycoprotein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with S11 Fab Homo sapiens; Human coronavirus 229E homo sapiens homo sapiens human coronavirus 229e Xiang, J.C., Zhao, W.W., Yang, B. 3.8 X-RAY DIFFRACTION 0.318 0.280 False True IGHV3 IGKV1 Kappa None None None None None 7wb5 H L 0 R protein NA surface glycoprotein VIRAL PROTEIN 10/26/22 local structure of hu33 and spike Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pulan, L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV1 Kappa None None None None None 7wbh U V 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/26/22 overall structure of hu33 and spike Homo sapiens; Severe acute respiratory syndrome-related coronavirus homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Pulan, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV1 Kappa None None None None None 7wbh O Q 0 B protein NA spike glycoprotein VIRAL PROTEIN 10/26/22 overall structure of hu33 and spike Homo sapiens; Severe acute respiratory syndrome-related coronavirus homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Pulan, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV1 Kappa None None None None None 7wbh P S 0 C protein NA spike glycoprotein VIRAL PROTEIN 10/26/22 overall structure of hu33 and spike Homo sapiens; Severe acute respiratory syndrome-related coronavirus homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Pulan, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV1 Kappa None None None None None 7wy5 N NA 0 A | B protein | protein NA | NA engineered mini g alpha q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/26/22 ADGRL3/Gq complex Homo sapiens; Mus musculus homo sapiens homo sapiens | homo sapiens He, Y., Qian, Y. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wy8 D NA 0 A | B protein | protein NA | NA engineered mini g alpha s subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/26/22 ADGRL3/Gs complex Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens He, Y., Qian, Y. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wyb E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/26/22 ADGRL3/Gi complex Homo sapiens; Mus musculus homo sapiens homo sapiens | homo sapiens He, Y., Qian, Y. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wz4 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/26/22 Structure of an orphan GPCR-G protein signaling complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, J., Chen, G., Liu, Z., Du, Y. 3.0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8ady H L 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 1 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 5.2 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8ady Q S 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 1 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 5.2 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8adz H L 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 2 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 6.7 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8adz U V 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 2 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 6.7 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8ae0 H L 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 3 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 7.1 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8ae0 Q S 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 3 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 7.1 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8ae2 H L 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 5 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 8.5 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8ae2 Q S 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 5 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 8.5 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8ae3 H L 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 4 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 6.8 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8ae3 Q S 0 NA NA NA NA IMMUNE SYSTEM 10/26/22 Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 4 Homo sapiens homo sapiens homo sapiens Chen, Q., Rosenthal, P., Tolar, P. 6.8 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 8erq H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 SARS-CoV-2 BA.1 spike ectodomain trimer in complex with the S2X324 neutralizing antibody Fab fragment (local refinement of the RBD and S2X324) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 8err H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 SARS-CoV-2 Omicron BA.1 spike ectodomain trimer in complex with the S2X324 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 8err E F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 SARS-CoV-2 Omicron BA.1 spike ectodomain trimer in complex with the S2X324 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 8err I J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/26/22 SARS-CoV-2 Omicron BA.1 spike ectodomain trimer in complex with the S2X324 neutralizing antibody Fab fragment Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7t4g H L 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/19/22 The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11 Macaca mulatta; Simian immunodeficiency virus macaca mulatta macaca mulatta simian immunodeficiency virus Berndsen, Z.T. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 7t4g G I 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/19/22 The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11 Macaca mulatta; Simian immunodeficiency virus macaca mulatta macaca mulatta simian immunodeficiency virus Berndsen, Z.T. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 7t4g J K 0 E protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/19/22 The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11 Macaca mulatta; Simian immunodeficiency virus macaca mulatta macaca mulatta simian immunodeficiency virus Berndsen, Z.T. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 7yr1 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with XG2v024 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7yr1 D F 0 B protein NA spike glycoprotein VIRAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with XG2v024 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7yr1 E G 0 C protein NA spike glycoprotein VIRAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with XG2v024 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ssc H L 0 P peptide NA envelope glycoprotein b peptide IMMUNE SYSTEM/VIRAL PROTEIN 10/19/22 TRL345 lineage ancestor I8 Fab bound to an HCMV gB-derived peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human betaherpesvirus 5 Sponholtz, M.R., McLellan, J.S. 1.8 X-RAY DIFFRACTION 0.174 0.150 False True IGHV3 IGKV3 Kappa None None None None None 7t2p H L 0 A | B protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 10/19/22 The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11 Macaca mulatta; Simian immunodeficiency virus macaca mulatta macaca mulatta simian immunodeficiency virus | simian immunodeficiency virus Berndsen, Z.T. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 7y24 S s 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 10/19/22 Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens | homo sapiens Chen, S., Zheng, S. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y26 D d 0 B | A protein | protein NA | NA engineered guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 10/19/22 Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Chen, S., Zheng, S. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y27 D d 0 B | A protein | protein NA | NA engineered guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 10/19/22 Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Chen, S., Zheng, S. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yqx H F 0 B protein NA spike glycoprotein STRUCTURAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state1) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yqx I G 0 A protein NA spike glycoprotein STRUCTURAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state1) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yqy H F 0 B protein NA spike glycoprotein STRUCTURAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yqy I G 0 A protein NA spike glycoprotein STRUCTURAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yqy J E 0 C protein NA spike glycoprotein STRUCTURAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state2) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yqz I G 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state3) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yqz J H 0 C protein NA spike glycoprotein VIRAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state3) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 3.84 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yr0 C B 0 A protein NA spike protein s1 VIRAL PROTEIN 10/19/22 SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (interface) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yv7 F E 0 A protein NA capsid protein vp1 STRUCTURAL PROTEIN 10/19/22 Cryo-EM structure of expanded coxsackievirus A16 empty particle in complex with antibody 9B5 Coxsackievirus A16 coxsackievirus a16 coxsackievirus a16 coxsackievirus a16 Cong, Y., Liu, C.X. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 8cz5 H L 0 A protein NA n11 p domain VIRAL PROTEIN/Immune System 10/19/22 N11 P domain 2D9 Fab P complex Lagovirus; Mus musculus mus musculus mus musculus lagovirus Leuthold, M., Kilic, T., Hansman, G. 2.645 X-RAY DIFFRACTION 0.223 0.194 False False IGHV9 IGKV12 Kappa None None None None None 8d8q H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/19/22 SARS-CoV-2 Spike RBD in complex with DMAbs 2130 and 2196 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, J., Cui, J., Pallesen, J. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 8d8q C B 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/19/22 SARS-CoV-2 Spike RBD in complex with DMAbs 2130 and 2196 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, J., Cui, J., Pallesen, J. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8d8r H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/19/22 SARS-CoV-2 Spike RBD in complex with DMAb 2196 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, J., Cui, J., Pallesen, J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sgf H L 0 A | a protein | protein NA | NA gpc-i53-50a | unknown VIRAL PROTEIN/IMMUNE SYSTEM 10/12/22 Lassa virus glycoprotein construct (Josiah GPC-I53-50A) in complex with LAVA01 antibody Lassa mammarenavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus lassa mammarenavirus | lassa mammarenavirus Antanasijevic, A., Brouwer, P.J.M., Ward, A.B. 4.41 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7sgf J K 0 B | b protein | protein NA | NA gpc-i53-50a | unknown VIRAL PROTEIN/IMMUNE SYSTEM 10/12/22 Lassa virus glycoprotein construct (Josiah GPC-I53-50A) in complex with LAVA01 antibody Lassa mammarenavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus lassa mammarenavirus | lassa mammarenavirus Antanasijevic, A., Brouwer, P.J.M., Ward, A.B. 4.41 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7sgf M N 0 C | c protein | protein NA | NA gpc-i53-50a | unknown VIRAL PROTEIN/IMMUNE SYSTEM 10/12/22 Lassa virus glycoprotein construct (Josiah GPC-I53-50A) in complex with LAVA01 antibody Lassa mammarenavirus; Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus lassa mammarenavirus | lassa mammarenavirus Antanasijevic, A., Brouwer, P.J.M., Ward, A.B. 4.41 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7sqw A B 0 C protein NA kcsa potassium channel MEMBRANE PROTEIN 10/12/22 Structure of the KcsA-W67F mutant with the activation gate in the closed conformation Mus musculus; Streptomyces mus musculus mus musculus streptomyces Cuello, L.G., Labro, A.J. 3.21 X-RAY DIFFRACTION 0.273 0.232 False True IGHV1 IGKV5 Kappa None None None None None 7t97 A B 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CH1-207 (HC4) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.144 X-RAY DIFFRACTION 0.227 0.194 False True IGHV3 IGKV1 Kappa None None None None None 7t97 C D 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CH1-207 (HC4) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.144 X-RAY DIFFRACTION 0.227 0.194 False True IGHV3 IGKV1 Kappa None None None None None 7t97 E F 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CH1-207 (HC4) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.144 X-RAY DIFFRACTION 0.227 0.194 False True IGHV3 IGKV1 Kappa None None None None None 7t97 H L 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CH1-207 (HC4) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.144 X-RAY DIFFRACTION 0.227 0.194 False True IGHV3 IGKV1 Kappa None None None None None 7t98 A B 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer VL-108 (LC33) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.97 X-RAY DIFFRACTION 0.274 0.192 False True IGHV3 IGKV1 Kappa None None None None None 7t98 H L 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer VL-108 (LC33) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.97 X-RAY DIFFRACTION 0.274 0.192 False True IGHV3 IGKV1 Kappa None None None None None 7t99 A B 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CL-205 (LC25) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.65 X-RAY DIFFRACTION 0.265 0.184 False True IGHV3 IGKV1 Kappa None None None None None 7t99 C D 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CL-205 (LC25) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.65 X-RAY DIFFRACTION 0.265 0.184 False True IGHV3 IGKV1 Kappa None None None None None 7t99 E F 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CL-205 (LC25) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.65 X-RAY DIFFRACTION 0.265 0.184 False True IGHV3 IGKV1 Kappa None None None None None 7t99 H L 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of engineered CYS-CYS fab dimer CL-205 (LC25) Homo sapiens homo sapiens homo sapiens Harris, S.F., Boenig, G.D.L. 2.65 X-RAY DIFFRACTION 0.265 0.184 False True IGHV3 IGKV1 Kappa None None None None None 7tgf B NA 0 A protein NA ricin chain a IMMUNE SYSTEM/TOXIN 10/12/22 Single-domain VHH intrabodies neutralize ricin toxin. Ricinus communis; Vicugna pacos vicugna pacos ricinus communis Rudolph, M.J., Mantis, N. 1.347 X-RAY DIFFRACTION 0.181 0.158 False True IGHV1 NA NA None None None None None 7tgi B NA 0 A protein NA ricin chain a IMMUNE SYSTEM/TOXIN 10/12/22 Single-domain VHH intrabodies neutralize ricin toxin Ricinus communis; Vicugna pacos vicugna pacos ricinus communis Rudolph, M.J. 2.104 X-RAY DIFFRACTION 0.222 0.176 False True IGHV1 NA NA None None None None None 7th2 C NA 0 A protein NA ricin a chain IMMUNE SYSTEM/TOXIN 10/12/22 Single-domain VHH intrabodies neutralize ricin toxin Ricinus communis; Vicugna pacos vicugna pacos ricinus communis Rudolph, M.J., Mantis, N. 1.838 X-RAY DIFFRACTION 0.187 0.149 False True IGHV1 NA NA None None None None None 7th2 D NA 0 B protein NA ricin a chain IMMUNE SYSTEM/TOXIN 10/12/22 Single-domain VHH intrabodies neutralize ricin toxin Ricinus communis; Vicugna pacos vicugna pacos ricinus communis Rudolph, M.J., Mantis, N. 1.838 X-RAY DIFFRACTION 0.187 0.149 False True IGHV1 NA NA None None None None None 7th3 B NA 0 A protein NA ricin chain a IMMUNE SYSTEM/TOXIN 10/12/22 Single-domain VHH intrabodies neutralize ricin toxin Ricinus communis; Vicugna pacos vicugna pacos ricinus communis Rudolph, M.J. 2.292 X-RAY DIFFRACTION 0.272 0.248 False True IGHV1 NA NA None None None None None 7uvf H L 0 A protein NA t-cell surface glycoprotein cd8 alpha chain IMMUNE SYSTEM 10/12/22 Crystal structure of ZED8 Fab complex with CD8 alpha Homo sapiens homo sapiens homo sapiens homo sapiens Yu, C., Davies, C., Koerber, J.T., Williams, S. 2.6 X-RAY DIFFRACTION 0.259 0.198 False True IGHV14 IGKV16 Kappa None None None None None 7uvf X Y 0 B protein NA t-cell surface glycoprotein cd8 alpha chain IMMUNE SYSTEM 10/12/22 Crystal structure of ZED8 Fab complex with CD8 alpha Homo sapiens homo sapiens homo sapiens homo sapiens Yu, C., Davies, C., Koerber, J.T., Williams, S. 2.6 X-RAY DIFFRACTION 0.259 0.198 False True IGHV14 IGKV16 Kappa None None None None None 7vmz H L 0 NA NA NA NA IMMUNE SYSTEM 10/12/22 Crystal structure of a human Coronavirus 229E antibody C04 Fab Homo sapiens homo sapiens homo sapiens Xiang, J.C., Yang, B. 2.85 X-RAY DIFFRACTION 0.285 0.248 False True IGHV3 IGKV1 Kappa None None None None None 7xp4 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/12/22 Cryo-EM structure of a class T GPCR in apo state Acetivibrio thermocellus; Homo sapiens homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Xu, W.X., Wu, L.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xp5 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/12/22 Cryo-EM structure of a class T GPCR in ligand-free state Acetivibrio thermocellus; Homo sapiens homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Xu, W.X., Wu, L.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xp6 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(t) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/12/22 Cryo-EM structure of a class T GPCR in active state Acetivibrio thermocellus; Homo sapiens homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Xu, W.X., Wu, L.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7y89 S s 0 C | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/12/22 Structure of the GPR17-Gi complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Ye, F., Chen, G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7zce E e 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 10/12/22 SARS-CoV-2 Spike protein in complex with the single chain fragment scFv76 Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Chaves-Sanjuan, A., Bolognesi, M. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7zce F f 0 B protein NA spike glycoprotein,fibritin VIRAL PROTEIN 10/12/22 SARS-CoV-2 Spike protein in complex with the single chain fragment scFv76 Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Chaves-Sanjuan, A., Bolognesi, M. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7zce G g 0 A protein NA spike glycoprotein,fibritin VIRAL PROTEIN 10/12/22 SARS-CoV-2 Spike protein in complex with the single chain fragment scFv76 Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Chaves-Sanjuan, A., Bolognesi, M. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7zcf E e 0 C protein NA spike glycoprotein,fibritin VIRAL PROTEIN 10/12/22 SARS-CoV-2 Spike RBD in complex with the single chain fragment scFv76 (Focused Refinement) Enterobacteria phage T4; Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Chaves-Sanjuan, A., Bolognesi, M. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8d3a H L 0 G carbohydrate MAN ALPHA-D-MANNOSE IMMUNE SYSTEM/ANTIGEN 10/12/22 Crystal Structure of DH475 Fab in complex with Man9 Homo sapiens homo sapiens homo sapiens Finkelstein, M., Fera, D. 2.9 X-RAY DIFFRACTION 0.272 0.229 False True IGHV3 IGLV4 Lambda None None None None None 8dfg H L 0 A protein NA merozoite surface protein 1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Patel, P.N., Tang, W.K., Tolia, N.H. 2 X-RAY DIFFRACTION 0.266 0.225 False True IGHV4 IGKV3 Kappa None None None None None 8dfg I M 0 B protein NA merozoite surface protein 1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Patel, P.N., Tang, W.K., Tolia, N.H. 2 X-RAY DIFFRACTION 0.266 0.225 False True IGHV4 IGKV3 Kappa None None None None None 8dfh H L 0 A protein NA merozoite surface protein 1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of non-neutralizing / interfering human monoclonal antibody 42C3 Fab in complex with MSP1-19 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Patel, P.N., Tang, W.K., Tolia, N.H. 2.3 X-RAY DIFFRACTION 0.233 0.209 False True IGHV3 IGLV1 Lambda None None None None None 8dfi H L 0 A protein NA merozoite surface protein 1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of moderately neutralizing / interfering human monoclonal antibody 42C11 Fab in complex with MSP1-19 Homo sapiens; Plasmodium falciparum 3D7 homo sapiens homo sapiens plasmodium falciparum 3d7 Patel, P.N., Tang, W.K., Tolia, N.H. 1.9 X-RAY DIFFRACTION 0.200 0.175 False True IGHV3 IGLV1 Lambda None None None None None 8gx9 H F 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of SARS-CoV-2 RBD with P2C-1F11 and P2B-1G5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J. 4.01 X-RAY DIFFRACTION 0.297 0.238 False True IGHV3 IGKV3 Kappa None None None None None 8gx9 I L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of SARS-CoV-2 RBD with P2C-1F11 and P2B-1G5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J. 4.01 X-RAY DIFFRACTION 0.297 0.238 False True IGHV3 IGKV3 Kappa None None None None None 8gx9 P M 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of SARS-CoV-2 RBD with P2C-1F11 and P2B-1G5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J. 4.01 X-RAY DIFFRACTION 0.297 0.238 False True IGHV7 IGLV3 Lambda None None None None None 8gx9 O N 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/12/22 Crystal structure of SARS-CoV-2 RBD with P2C-1F11 and P2B-1G5 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J. 4.01 X-RAY DIFFRACTION 0.297 0.238 False True IGHV7 IGLV3 Lambda None None None None None 7s7i H L 0 A protein NA mhc class i chain-related protein a IMMUNE SYSTEM 10/05/22 Crystal structure of Fab in complex with MICA alpha3 domain Homo sapiens homo sapiens homo sapiens homo sapiens Lee, P.S., Strop, P. 2.4 X-RAY DIFFRACTION 0.260 0.220 False True IGHV3 IGKV3 Kappa None None None None None 7s7i I M 0 B protein NA mhc class i chain-related protein a IMMUNE SYSTEM 10/05/22 Crystal structure of Fab in complex with MICA alpha3 domain Homo sapiens homo sapiens homo sapiens homo sapiens Lee, P.S., Strop, P. 2.4 X-RAY DIFFRACTION 0.260 0.220 False True IGHV3 IGKV3 Kappa None None None None None 7s7i J N 0 C protein NA mhc class i chain-related protein a IMMUNE SYSTEM 10/05/22 Crystal structure of Fab in complex with MICA alpha3 domain Homo sapiens homo sapiens homo sapiens homo sapiens Lee, P.S., Strop, P. 2.4 X-RAY DIFFRACTION 0.260 0.220 False True IGHV3 IGKV3 Kappa None None None None None 7s7i U V 0 D protein NA mhc class i chain-related protein a IMMUNE SYSTEM 10/05/22 Crystal structure of Fab in complex with MICA alpha3 domain Homo sapiens homo sapiens homo sapiens homo sapiens Lee, P.S., Strop, P. 2.4 X-RAY DIFFRACTION 0.260 0.220 False True IGHV3 IGKV3 Kappa None None None None None 7s7i W X 0 E protein NA mhc class i chain-related protein a IMMUNE SYSTEM 10/05/22 Crystal structure of Fab in complex with MICA alpha3 domain Homo sapiens homo sapiens homo sapiens homo sapiens Lee, P.S., Strop, P. 2.4 X-RAY DIFFRACTION 0.260 0.220 False True IGHV3 IGKV3 Kappa None None None None None 7s7i Y Z 0 F protein NA mhc class i chain-related protein a IMMUNE SYSTEM 10/05/22 Crystal structure of Fab in complex with MICA alpha3 domain Homo sapiens homo sapiens homo sapiens homo sapiens Lee, P.S., Strop, P. 2.4 X-RAY DIFFRACTION 0.260 0.220 False True IGHV3 IGKV3 Kappa None None None None None 7sa6 H L 0 A protein NA factor h-binding protein 2416 IMMUNE SYSTEM 10/05/22 fHbp mutant 2416 bound to Fab JAR5 Mus musculus; Neisseria meningitidis serogroup B mus musculus mus musculus neisseria meningitidis serogroup b Chesterman, C., Malito, E., Bottomley, M.J. 2.9 X-RAY DIFFRACTION 0.290 0.249 False True IGHV1 IGKV2 Kappa None None None None None 7sbz A B 0 D protein NA factor h-binding protein IMMUNE SYSTEM 10/05/22 JAR5 Fab bound to fHbp v1.1 crystallized in space group I422 Mus musculus; Neisseria meningitidis serogroup B mus musculus mus musculus neisseria meningitidis serogroup b Chesterman, C., Malito, E., Bottomley, M.J. 2.9 X-RAY DIFFRACTION 0.296 0.248 False True IGHV1 IGKV2 Kappa None None None None None 7sbz H L 0 C protein NA factor h-binding protein IMMUNE SYSTEM 10/05/22 JAR5 Fab bound to fHbp v1.1 crystallized in space group I422 Mus musculus; Neisseria meningitidis serogroup B mus musculus mus musculus neisseria meningitidis serogroup b Chesterman, C., Malito, E., Bottomley, M.J. 2.9 X-RAY DIFFRACTION 0.296 0.248 False True IGHV1 IGKV2 Kappa None None None None None 7ti6 H L 0 NA NA NA NA IMMUNE SYSTEM 10/05/22 Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage Homo sapiens homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 2.64 X-RAY DIFFRACTION 0.253 0.229 False True IGHV3 IGKV3 Kappa None None None None None 7xrp B NA 0 F | A protein | protein NA | NA spike protein s1 | spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/05/22 Cryo-EM structure of SARS-CoV-2 spike protein in complex with nanobody C5G2 (localized refinement) Camelus dromedarius; Severe acute respiratory syndrome coronavirus 2 camelus dromedarius severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Liu, L., Sun, H., Jiang, Y., Liu, X., Zhao, D., Zheng, Q., Li, S., Xia, N. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yu3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/05/22 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Akasaka, H., Shihoya, W., Nureki, O. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yu5 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/05/22 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state1 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Akasaka, H., Shihoya, W., Nureki, O. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yu6 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/05/22 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state2 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Akasaka, H., Shihoya, W., Nureki, O. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yu7 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/05/22 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state3 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Akasaka, H., Shihoya, W., Nureki, O. 3.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yu8 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/05/22 Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4 Bos taurus; Homo sapiens; Mus musculus; Rattus norvegicus mus musculus homo sapiens | rattus norvegicus Akasaka, H., Shihoya, W., Nureki, O. 4.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7yzi C NA 0 B protein NA adenylate cyclase MEMBRANE PROTEIN 10/05/22 Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya Mycobacterium tuberculosis '98-R604 INH-RIF-EM'; Vicugna pacos vicugna pacos mycobacterium tuberculosis '98-r604 inh-rif-em' Mehta, V., Khanppnavar, B., Korkhov, V.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yzi D NA 0 A protein NA adenylate cyclase MEMBRANE PROTEIN 10/05/22 Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya Mycobacterium tuberculosis '98-R604 INH-RIF-EM'; Vicugna pacos vicugna pacos mycobacterium tuberculosis '98-r604 inh-rif-em' Mehta, V., Khanppnavar, B., Korkhov, V.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yzi E NA 0 B protein NA adenylate cyclase MEMBRANE PROTEIN 10/05/22 Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya Mycobacterium tuberculosis '98-R604 INH-RIF-EM'; Vicugna pacos vicugna pacos mycobacterium tuberculosis '98-r604 inh-rif-em' Mehta, V., Khanppnavar, B., Korkhov, V.M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7x3c H L 0 A | C protein | protein NA | NA virion protein 1 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 muture virion in complex with nAbs 8A10 and 5F5 (CVB1-M:8A10:5F5) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.03 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x3c F E 0 B protein NA vp2 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 muture virion in complex with nAbs 8A10 and 5F5 (CVB1-M:8A10:5F5) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.03 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 7t9a J K 0 F protein NA hiv envelope apexgt2 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT2 in complex with GT2-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 Berndsen, Z.T. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t9a M N 0 B protein NA hiv envelope apexgt2 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT2 in complex with GT2-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 Berndsen, Z.T. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t9a O P 0 D | E protein | protein NA | NA hiv envelope apexgt2 gp41 | hiv envelope apexgt2 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT2 in complex with GT2-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t9a H L 0 A | C protein | protein NA | NA hiv envelope apexgt2 gp120 | hiv envelope apexgt2 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT2 in complex with GT2-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7t9b J K 0 F protein NA hiv-1 envelope apexgt5 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 Berndsen, Z.T. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t9b M N 0 B protein NA hiv-1 envelope apexgt5 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 Berndsen, Z.T. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t9b O P 0 D protein NA hiv-1 envelope apexgt5 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus macaca mulatta macaca mulatta human immunodeficiency virus 1 Berndsen, Z.T. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t9b H L 0 E | C | A protein | protein | protein NA | NA | NA hiv-1 envelope apexgt5 gp120 | hiv-1 envelope apexgt5 gp120 | hiv-1 envelope apexgt5 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs Human immunodeficiency virus 1; Macaca mulatta; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7t74 K G 0 D protein NA hiv envelope apexgt2 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT2 in complex with PCT64.35S Fab and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Berndsen, Z.T. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t74 H L 0 A | E protein | protein NA | NA hiv envelope apexgt2 gp120 | hiv envelope apexgt2 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT2 in complex with PCT64.35S Fab and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7t74 M N 0 F | C protein | protein NA | NA hiv envelope apexgt2 gp41 | hiv envelope apexgt2 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT2 in complex with PCT64.35S Fab and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t74 I J 0 B protein NA hiv envelope apexgt2 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT2 in complex with PCT64.35S Fab and RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1; Macaca mulatta macaca mulatta macaca mulatta human immunodeficiency virus 1 Berndsen, Z.T. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t75 H L 0 B | A protein | protein NA | NA hiv envelope apexgt2 gp41 | hiv envelope apexgt2 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT2 in complex with RM20A3 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t76 H L 0 E | C | A protein | protein | protein NA | NA | NA hiv envelope apexgt3 gp120 | hiv envelope apexgt3 gp120 | hiv envelope apexgt3 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT3 in complex with PG9.iGL Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 4.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7t73 H L 0 E | C | A protein | protein | protein NA | NA | NA hiv envelope apexgt2.2mut gp120 | hiv envelope apexgt2.2mut gp120 | hiv envelope apexgt2.2mut gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT2.2MUT in complex with PCT64.LMCA Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7t77 H L 0 E | C | A protein | protein | protein NA | NA | NA hiv envelope apexgt3.n130 gp120 | hiv envelope apexgt3.n130 gp120 | hiv envelope apexgt3.n130 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 HIV-1 Envelope ApexGT3.N130 in complex with PG9 Fab Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T. 4.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7x2g H L 0 B protein NA vp2 VIRUS 01/08/09 Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb nAb 2E6 (CVB1-E:2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.58 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV12 Kappa None None None None None 7x37 H L 0 B protein NA vp2 VIRUS 01/08/09 Cryo-EM structure of Coxsackievirus B1 A particle in complex with nAb 2E6 (CVB1-A:2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.31 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV12 Kappa None None None None None 7x38 H L 0 A | C | B protein | protein | protein NA | NA | NA virion protein 1 | vp3 | vp2 VIRUS 01/08/09 Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 8A10 (CVB1-E:8A10) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.52 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x3f H L 0 B | C protein | protein NA | NA vp2 | vp3 VIRUS 01/08/09 Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 9A3 (CVB1-A:9A3) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.52 ELECTRON MICROSCOPY NA NA False False IGHV7 IGKV4 Kappa None None None None None 7x4k H L 0 B | C protein | protein NA | NA genome polyprotein | vp3 VIRUS 01/08/09 Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 9A3 (classified from CVB1 mature virion in complex with 8A10 and 9A3) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.82 ELECTRON MICROSCOPY NA NA False False IGHV7 IGKV4 Kappa None None None None None 7nxx B NA 0 A protein NA superoxide dismutase [cu-zn] METAL BINDING PROTEIN 09/28/22 Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2). Camelus dromedarius; Homo sapiens camelus dromedarius homo sapiens Gallardo, R., Rousseau, F., Schymkowitz, J., Ulens, C. 2.189 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 NA NA None None None None None 7v6o E D 0 A protein NA spike glycoprotein PROTEIN BINDING 09/28/22 MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 4.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v6o G F 0 B protein NA spike glycoprotein PROTEIN BINDING 09/28/22 MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 4.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v6o I H 0 C protein NA spike glycoprotein PROTEIN BINDING 09/28/22 MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 4.56 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7vie E e 0 D | A protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/28/22 Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yu, L.Y., Gan, B., Xiao, Q.J., Ren, R.B. 2.86 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7vif E e 0 D | A protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/28/22 Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yu, L.Y., Gan, B., Xiao, Q.J., Ren, R.B. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7vig E e 0 D | A protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/28/22 Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yu, L.Y., Gan, B., Xiao, Q.J., Ren, R.B. 2.89 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7vih E e 0 D | A protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/28/22 Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Yu, L.Y., Gan, B., Xiao, Q.J., Ren, R.B. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7w6p H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/22 Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, J., Fink, E.A., Shoichet, B.K., Du, Y. 3.47 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7w7e H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/22 Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Xu, J., Fink, E.A., Shoichet, B.K., Du, Y. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wrj A B 0 R protein NA spike protein s1 VIRAL PROTEIN 09/28/22 Local CryoEM structure of the SARS-CoV-2 S6P(B.1.1.529) in complex with BD55-4637 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 7wry H L 0 R protein NA spike protein s1 VIRAL PROTEIN 09/28/22 Local structure of BD55-3546 Fab and SARS-COV2 Delta RBD complex SARS coronavirus B012 sars coronavirus b012 sars coronavirus b012 sars coronavirus b012 Zhang, Z.Z., Xiao, J.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV3 Kappa None None None None None 7wxu N NA 0 A | B protein | protein NA | NA engineered mini galpha-q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/22 GPR110/Gq complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Zhu, X. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wxw D NA 0 A | B protein | protein NA | NA engineered mini galpha-s subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/22 GPR110/Gs complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens He, Y., Zhu, X. 2.84 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wy0 C c 0 A | B protein | protein NA | NA engineered g alpha 13 subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/22 GPR110/G13 complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Zhu, X. 2.83 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wz7 C c 0 A | B protein | protein NA | NA engineered g alpha 12 subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/22 GPR110/G12 complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Zhu, X. 2.83 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7x2i H L 0 B protein NA vp2 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 pre-A particle in complex with nAb 2E6 (CVB1-pre-A:2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.29 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV12 Kappa None None None None None 7x2o H L 0 B protein NA vp2 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 2E6 (CVB1-M:2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.15 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV12 Kappa None None None None None 7x2t H L 0 A | B | C protein | protein | protein NA | NA | NA virion protein 1 | vp2 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (CVB1-M:8A10) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.69 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x2v E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/22 GPR110/Gi complex Homo sapiens homo sapiens homo sapiens | homo sapiens He, Y., Zhu, X. 3.09 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7x2w H L 0 A | B | C protein | protein | protein NA | NA | NA virion protein 1 | vp2 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 pre-A particle in complex with nAb 8A10 (CVB1-pre-A:8A10) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.24 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x3d H L 0 B | C protein | protein NA | NA vp2 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 9A3 (CVB1-M:9A3) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.48 ELECTRON MICROSCOPY NA NA False False IGHV7 IGKV4 Kappa None None None None None 7x3e H L 0 B | C protein | protein NA | NA vp2 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 pre-A-particle in complex with nAb 9A3 (CVB1-pre-A:9A3) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.44 ELECTRON MICROSCOPY NA NA False False IGHV7 IGKV4 Kappa None None None None None 7x40 H L 0 A | B | C protein | protein | protein NA | NA | NA virion protein 1 | vp2 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (classified from CVB1 mature virion in complex with 8A10 and 2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.02 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x42 H L 0 A | B | C protein | protein | protein NA | NA | NA virion protein 1 | capsid protein vp0 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 pre-A-particle in complex with nAb 8A10 (classified from CVB1 mature virion in complex with 8A10 and 2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.88 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x46 H L 0 B protein NA vp2 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 2E6 (classified from CVB1 mature virion in complex with 8A10 and 2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.85 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV12 Kappa None None None None None 7x47 H L 0 B protein NA vp2 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 2E6 (classified from CVB1 mature virion in complex with 8A10 and 2E6) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.66 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV12 Kappa None None None None None 7x49 H L 0 A | B | C protein | protein | protein NA | NA | NA virion protein 1 | vp2 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (classified from CVB1 mature virion in complex with 8A10 and 9A3) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.13 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x4m H L 0 A | B | C protein | protein | protein NA | NA | NA virion protein 1 | vp2 | vp3 VIRUS 09/28/22 Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (classified from CVB1 mature virion in complex with 8A10, 2E6 and 9A3) Coxsackievirus B1; Mus musculus mus musculus mus musculus coxsackievirus b1 | coxsackievirus b1 | coxsackievirus b1 Zheng, Q., Zhu, R., Sun, H., Cheng, T., Li, S., Xia, N. 3.34 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7y0c A B 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/28/22 Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z., Xiao, J. 2.94 X-RAY DIFFRACTION 0.278 0.202 False True IGHV1 IGKV3 Kappa None None None None None 7y0c M N 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/28/22 Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z., Xiao, J. 2.94 X-RAY DIFFRACTION 0.278 0.202 False True IGHV1 IGKV3 Kappa None None None None None 7y0v H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/28/22 The co-crystal structure of BA.1-RBD with Fab-5549 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J.Y., Zhang, Y. 2.48 X-RAY DIFFRACTION 0.268 0.211 False True IGHV4 IGLV3 Lambda None None None None None 7y0w A B 0 R protein NA spike protein s1 VIRAL PROTEIN 09/28/22 Local structure of BD55-5514 and BD55-5840 Fab and Omicron BA.1 RBD complex Homo sapiens homo sapiens homo sapiens homo sapiens Zhang, Z., Xiao, J. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7y0w H L 0 R protein NA spike protein s1 VIRAL PROTEIN 09/28/22 Local structure of BD55-5514 and BD55-5840 Fab and Omicron BA.1 RBD complex Homo sapiens homo sapiens homo sapiens homo sapiens Zhang, Z., Xiao, J. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV3 Kappa None None None None None 8ds5 C B 0 A protein NA cd27 antigen IMMUNE SYSTEM 09/28/22 X-ray structure of the MK5890 Fab - CD27 antibody-antigen complex Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Fischmann, T.O. 1.926 X-RAY DIFFRACTION 0.225 0.209 False True IGHV9 IGKV3 Kappa None None None None None 8e7m H L 0 A protein NA angiotensin-converting enzyme 2 ANTIVIRAL PROTEIN 09/28/22 Structure of the human ACE2 receptor in complex with antibody Fab fragment, 05B04 Homo sapiens homo sapiens homo sapiens homo sapiens Barnes, C.O. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zlk H L 0 D protein NA amc009 sosipv5.2 envelope glycoprotein gp120 VIRAL PROTEIN 09/21/22 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ozorowski, G., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 7zlk M N 0 F protein NA amc009 sosipv5.2 envelope glycoprotein gp41 VIRAL PROTEIN 09/21/22 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ozorowski, G., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 7zlk O P 0 A protein NA amc009 sosipv5.2 envelope glycoprotein gp120 VIRAL PROTEIN 09/21/22 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ozorowski, G., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 7zlk Q R 0 C protein NA amc009 sosipv5.2 envelope glycoprotein gp120 VIRAL PROTEIN 09/21/22 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ozorowski, G., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 7zlk S T 0 E | B protein | protein NA | NA amc009 sosipv5.2 envelope glycoprotein gp41 | amc009 sosipv5.2 envelope glycoprotein gp41 VIRAL PROTEIN 09/21/22 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 van Schooten, J., Ozorowski, G., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 7srr E e 0 B | C protein | protein NA | NA g protein subunit q (gi2-mini-gq chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/21/22 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) Homo sapiens homo sapiens homo sapiens | homo sapiens Barros-Alvarez, X., Kim, K., Panova, O., Cao, C., Roth, B.L., Skiniotis, G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7srs Q P 0 R protein NA 5-hydroxytryptamine receptor 2b MEMBRANE PROTEIN 09/21/22 5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Barros-Alvarez, X., Cao, C., Panova, O., Roth, B.L., Skiniotis, G. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7srs H L 0 C protein NA isoform 1b of beta-arrestin-1 MEMBRANE PROTEIN 09/21/22 5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Barros-Alvarez, X., Cao, C., Panova, O., Roth, B.L., Skiniotis, G. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ut3 H L 0 L Hapten TI0 4-nitrophenyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside IMMUNE SYSTEM 09/21/22 Crystal structure of complex of Fab, G10C with GalNAc-pNP Mus musculus mus musculus mus musculus mus musculus Li, M., Wlodawer, A. 3 X-RAY DIFFRACTION 0.240 0.186 False True IGHV5 IGKV4 Kappa None None None None None 7v5j E D 0 A protein NA spike glycoprotein PROTEIN BINDING 09/21/22 MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v5j G F 0 C protein NA spike glycoprotein PROTEIN BINDING 09/21/22 MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v5j I H 0 B protein NA spike glycoprotein PROTEIN BINDING 09/21/22 MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7vfx S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/PROTEIN BINDING 09/21/22 The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Wang, X.K., Chen, G., Liao, Q.W., Du, Y., Hu, H.L., Ye, D.Q. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xco H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/21/22 Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with S309 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Qi, J.X., Zhao, Z.N., Liu, S., Xie, Y.F. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7xco M N 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/21/22 Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with S309 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Qi, J.X., Zhao, Z.N., Liu, S., Xie, Y.F. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7xco O P 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/21/22 Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with S309 fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Qi, J.X., Zhao, Z.N., Liu, S., Xie, Y.F. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dke A B 0 P protein NA isoform 2 of cystinosin MEMBRANE PROTEIN/Transport protein 09/21/22 Cryo-EM structure of cystinosin in a cytosol-open state Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Schmiege, P., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV15 Kappa None None None None None 8dki A B 0 P protein NA isoform 2 of cystinosin MEMBRANE PROTEIN/Transport protein 09/21/22 Cryo-EM structure of cystinosin in a lumen-open state Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Schmiege, P., Li, X. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV15 Kappa None None None None None 8dkm A B 0 P protein NA isoform 2 of cystinosin MEMBRANE PROTEIN/Transport protein 09/21/22 Cryo-EM structure of cystine-bound cystinosin in a lumen-open state Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Schmiege, P., Li, X. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV15 Kappa None None None None None 8dkw A B 0 P protein NA isoform 2 of cystinosin MEMBRANE PROTEIN/Transport protein 09/21/22 Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Schmiege, P., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV15 Kappa None None None None None 8dkx A B 0 P protein NA isoform 2 of cystinosin MEMBRANE PROTEIN/Transport protein 09/21/22 Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Schmiege, P., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV15 Kappa None None None None None 7b5g B NA 0 A protein NA lexa repressor TRANSCRIPTION 09/14/22 Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527) Escherichia coli K-12; Lama glama lama glama escherichia coli k-12 Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.4 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 NA NA None None None None None 7b5g D NA 0 C protein NA lexa repressor TRANSCRIPTION 09/14/22 Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527) Escherichia coli K-12; Lama glama lama glama escherichia coli k-12 Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.4 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 NA NA None None None None None 7b5g F NA 0 E protein NA lexa repressor TRANSCRIPTION 09/14/22 Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527) Escherichia coli K-12; Lama glama lama glama escherichia coli k-12 Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.4 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 NA NA None None None None None 7b5g H NA 0 G protein NA lexa repressor TRANSCRIPTION 09/14/22 Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527) Escherichia coli K-12; Lama glama lama glama escherichia coli k-12 Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L. 2.4 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 NA NA None None None None None 7r0c D d 0 C | A protein | protein NA | NA arrestin2 | vasopressin v2 receptor MEMBRANE PROTEIN 09/14/22 Structure of the AVP-V2R-arrestin2-ScFv30 complex Homo sapiens; synthetic construct; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Bous, J., Fouillen, A., Trapani, S., Granier, S., Mouillac, B., Bron, P. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7r0j D d 0 C | A protein | peptide NA | NA arrestin2 | v2r cter MEMBRANE PROTEIN 09/14/22 Structure of the V2 receptor Cter-arrestin2-ScFv30 complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens Bous, J., Fouillen, A., Trapani, S., Granier, S., Mouillac, B., Bron, P. 4.23 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7sah B NA 0 NA NA NA NA IMMUNE SYSTEM 09/14/22 Crystal Structure of LaG16 Nanobody bound to eGFP Aequorea victoria; Lama glama lama glama Cong, A.T.Q., Schellenberg, M.J. 1.6 X-RAY DIFFRACTION 0.177 0.156 False True IGHV1 NA NA None None None None None 7sai C NA 0 A protein NA green fluorescent protein IMMUNE SYSTEM 09/14/22 Crystal Structure of Lag30 Nanobody bound to eGFP Aequorea victoria; Lama glama lama glama aequorea victoria Cong, A.T.Q., Schellenberg, M.J. 2.23 X-RAY DIFFRACTION 0.197 0.171 False True IGHV1 NA NA None None None None None 7saj B NA 0 A protein NA mcherry IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM2 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama discosoma sp. Cong, A.T.Q., Schellenberg, M.J. 2.37 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 7saj D NA 0 C protein NA mcherry IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM2 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama discosoma sp. Cong, A.T.Q., Schellenberg, M.J. 2.37 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 7saj F NA 0 E protein NA mcherry IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM2 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama discosoma sp. Cong, A.T.Q., Schellenberg, M.J. 2.37 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 7saj H NA 0 G protein NA mcherry IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM2 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama discosoma sp. Cong, A.T.Q., Schellenberg, M.J. 2.37 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 7saj J NA 0 I protein NA mcherry IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM2 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama discosoma sp. Cong, A.T.Q., Schellenberg, M.J. 2.37 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 7sak B NA 0 A protein NA mcherry IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM4 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama discosoma sp. Cong, A.T.Q., Schellenberg, M.J. 1.15 X-RAY DIFFRACTION 0.144 0.117 False True IGHV1 NA NA None None None None None 7sal C NA 0 NA NA NA NA IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM6 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama Cong, A.T.Q., Schellenberg, M.J. 1.93 X-RAY DIFFRACTION 0.191 0.161 False True IGHV1 NA NA None None None None None 7sal D NA 0 NA NA NA NA IMMUNE SYSTEM 09/14/22 Crystal Structure of LaM6 Nanobody bound to mCherry Discosoma sp.; Lama glama lama glama Cong, A.T.Q., Schellenberg, M.J. 1.93 X-RAY DIFFRACTION 0.191 0.161 False True IGHV1 NA NA None None None None None 7tjq A B 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S., Rush, S.A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7tjq D E 0 G protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S., Rush, S.A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7tjq H L 0 F protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S., Rush, S.A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7tjq I M 0 F protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S., Rush, S.A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7tjq J K 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S., Rush, S.A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7tjq N O 0 G protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S., Rush, S.A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7tl0 D E 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2 Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Rush, S.A., Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7tl0 F G 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2 Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Rush, S.A., Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7tl0 H I 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2 Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Rush, S.A., Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7tl0 J K 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2 Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Rush, S.A., Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7tl0 L M 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2 Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Rush, S.A., Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7tl0 N O 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 09/14/22 Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2 Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Rush, S.A., Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7upm B NA 0 A protein NA tribbles homolog 2 SIGNALING PROTEIN/IMMUNE SYSTEM 09/14/22 Tribbles (TRIB2) pseudokinase bound to nanobody Nb4.103 Homo sapiens; synthetic construct synthetic construct homo sapiens Jamieson, S.A., Mace, P.D. 2.7 X-RAY DIFFRACTION 0.260 0.202 False True IGHV1 NA NA None None None None None 7v6n E D 0 A protein NA spike glycoprotein PROTEIN BINDING 09/14/22 MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 3.99 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v6n G F 0 B protein NA spike glycoprotein PROTEIN BINDING 09/14/22 MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 3.99 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7v6n I H 0 C protein NA spike glycoprotein PROTEIN BINDING 09/14/22 MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Zeng, J., Zhang, S., Wang, Y. 3.99 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ven B A 0 NA NA NA NA IMMUNE SYSTEM 09/14/22 Structure of burosumab Fab Homo sapiens homo sapiens homo sapiens Heo, Y.S. 1.45 X-RAY DIFFRACTION 0.196 0.169 False True IGHV1 IGKV1 Kappa None None None None None 7x5h E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/14/22 Serotonin 5A (5-HT5A) receptor-Gi protein complex Escherichia coli; Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Tan, Y., Xu, P., Huang, S., Xu, H.E., Jiang, Y. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xxl A C 0 B protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 09/14/22 RBD in complex with Fab14 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lin, J.Q., Tan, Y.J.E., Wu, B., Lescar, J. 0 ELECTRON MICROSCOPY NA NA False True IGHV6 IGLV2 Lambda None None None None None 7yrf F E 0 C protein NA capsid protein vp3 STRUCTURAL PROTEIN 09/14/22 Cryo-EM structure of compact CA16 empty particle in complex with a neutralizing antibody 8C4 Coxsackievirus A16 coxsackievirus a16 coxsackievirus a16 coxsackievirus a16 Cong, Y., Liu, C.X. 2.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 7yrh F E 0 A protein NA capsid protein vp1 STRUCTURAL PROTEIN 09/14/22 Cryo-EM structure of compact coxsackievirus A16 empty particle in complex with a neutralizing antibody 9B5 Coxsackievirus A16 coxsackievirus a16 coxsackievirus a16 coxsackievirus a16 Cong, Y., Liu, C.X. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7phs H L 0 NA NA NA NA IMMUNE SYSTEM 09/07/22 highly potent IL6 antagonistic antibody selected from a camelid immune phage display repertoire Lama glama lama glama lama glama Cambillau, C., Pannecoucke, E., De Haard, H. 2.77 X-RAY DIFFRACTION 0.303 0.273 False True IGHV4 IGLV2 Lambda None None None None None 7pkl L l 0 NA NA NA NA IMMUNE SYSTEM 09/07/22 Mechanistic understanding of antibody masking with anti-idiotypic antibody fragments Homo sapiens homo sapiens Hargreaves, D. 2.35 X-RAY DIFFRACTION 0.265 0.180 True True unknown unknown unknown None None None None None 7pkl H NA 0 NA NA NA NA IMMUNE SYSTEM 09/07/22 Mechanistic understanding of antibody masking with anti-idiotypic antibody fragments Homo sapiens homo sapiens Hargreaves, D. 2.35 X-RAY DIFFRACTION 0.265 0.180 False True IGHV3 NA NA None None None None None 7sjm H L 0 NA NA NA NA IMMUNE SYSTEM 09/07/22 anti-HtrA1 Fab15H6.v4 Homo sapiens homo sapiens homo sapiens Ultsch, M.H., Gerhardy, S. 1.8 X-RAY DIFFRACTION 0.202 0.171 False True IGHV1 IGKV1 Kappa None None None None None 7sjn D E 0 B protein NA serine protease htra1 HYDROLASE/Immune System 09/07/22 HtrA1:Fab15H6.v4 complex Homo sapiens homo sapiens homo sapiens homo sapiens Gerhardy, S., Green, E., Estevez, A., Arthur, C.P., Ultsch, M., Rohou, A., Kirchhofer, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7sjn F G 0 C protein NA serine protease htra1 HYDROLASE/Immune System 09/07/22 HtrA1:Fab15H6.v4 complex Homo sapiens homo sapiens homo sapiens homo sapiens Gerhardy, S., Green, E., Estevez, A., Arthur, C.P., Ultsch, M., Rohou, A., Kirchhofer, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7sjn H L 0 A protein NA serine protease htra1 HYDROLASE/Immune System 09/07/22 HtrA1:Fab15H6.v4 complex Homo sapiens homo sapiens homo sapiens homo sapiens Gerhardy, S., Green, E., Estevez, A., Arthur, C.P., Ultsch, M., Rohou, A., Kirchhofer, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7sjo E F 0 C protein NA serine protease htra1 HYDROLASE/Immune System 09/07/22 HtrA1S328A:Fab15H6.v4 complex Homo sapiens homo sapiens homo sapiens homo sapiens Gerhardy, S., Green, E., Estevez, A., Arthur, C.P., Ultsch, M., Rohou, A., Kirchhofer, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7sjo H L 0 A protein NA serine protease htra1 HYDROLASE/Immune System 09/07/22 HtrA1S328A:Fab15H6.v4 complex Homo sapiens homo sapiens homo sapiens homo sapiens Gerhardy, S., Green, E., Estevez, A., Arthur, C.P., Ultsch, M., Rohou, A., Kirchhofer, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7sjo I J 0 B protein NA serine protease htra1 HYDROLASE/Immune System 09/07/22 HtrA1S328A:Fab15H6.v4 complex Homo sapiens homo sapiens homo sapiens homo sapiens Gerhardy, S., Green, E., Estevez, A., Arthur, C.P., Ultsch, M., Rohou, A., Kirchhofer, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7sjp H L 0 E peptide NA htra1-loopa peptide IMMUNE SYSTEM 09/07/22 anti-HtrA1 Fab15H6.v4 bound to HtrA1-LoopA peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Ultsch, M.H., Gerhardy, S. 2.1 X-RAY DIFFRACTION 0.199 0.168 False True IGHV1 IGKV1 Kappa None None None None None 7tuf H L 0 D protein NA tapasin IMMUNE SYSTEM 09/07/22 Crystal structure of Tapasin in complex with PaSta1-Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jiang, J., Natarajan, K., Taylor, D.K., Boyd, L.F., Margulies, D.H. 2.8 X-RAY DIFFRACTION 0.274 0.231 False True IGHV3 IGKV4 Kappa None None None None None 7tuf A B 0 C protein NA tapasin IMMUNE SYSTEM 09/07/22 Crystal structure of Tapasin in complex with PaSta1-Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jiang, J., Natarajan, K., Taylor, D.K., Boyd, L.F., Margulies, D.H. 2.8 X-RAY DIFFRACTION 0.274 0.231 False True IGHV3 IGKV4 Kappa None None None None None 7tug H L 0 D protein NA tapasin IMMUNE SYSTEM 09/07/22 Crystal structure of Tapasin in complex with PaSta2-Fab Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Jiang, J., Natarajan, K., Taylor, D.K., Boyd, L.F., Margulies, D.H. 3.9 X-RAY DIFFRACTION 0.332 0.282 False True IGHV1 IGKV8 Kappa None None None None None 7tuh H L 0 NA NA NA NA IMMUNE SYSTEM 09/07/22 Crystal structure of anti-tapasin PaSta2-Fab Mus musculus mus musculus mus musculus Jiang, J., Natarajan, K., Taylor, D.K., Boyd, L.F., Margulies, D.H. 2.3 X-RAY DIFFRACTION 0.240 0.218 False True IGHV1 IGKV8 Kappa None None None None None 7tuh A B 0 NA NA NA NA IMMUNE SYSTEM 09/07/22 Crystal structure of anti-tapasin PaSta2-Fab Mus musculus mus musculus mus musculus Jiang, J., Natarajan, K., Taylor, D.K., Boyd, L.F., Margulies, D.H. 2.3 X-RAY DIFFRACTION 0.240 0.218 False True IGHV1 IGKV8 Kappa None None None None None 7um3 I M 0 B peptide NA d1 domain loop peptide from lymphocyte activation gene 3protein IMMUNE SYSTEM 09/07/22 Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zorn, J.A., Lee, P.S., Rajpal, A., Strop, P. 2.3983 X-RAY DIFFRACTION 0.265 0.206 False True IGHV4 IGKV3 Kappa None None None None None 7um3 H L 0 A peptide NA d1 domain loop peptide from lymphocyte activation gene 3protein IMMUNE SYSTEM 09/07/22 Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zorn, J.A., Lee, P.S., Rajpal, A., Strop, P. 2.3983 X-RAY DIFFRACTION 0.265 0.206 False True IGHV4 IGKV3 Kappa None None None None None 7w71 H L 0 A protein NA regulator of sigma-e protease rsep HYDROLASE/IMMUNE SYSTEM 09/07/22 Crystal structure of the PDZ-C domain of E. coli RseP in complex with 12C7 Fab Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hirose, T., Katagiri, S., Nogi, T. 3.2 X-RAY DIFFRACTION 0.289 0.243 False True IGHV1 IGKV5 Kappa None None None None None 7w71 I M 0 B protein NA regulator of sigma-e protease rsep HYDROLASE/IMMUNE SYSTEM 09/07/22 Crystal structure of the PDZ-C domain of E. coli RseP in complex with 12C7 Fab Escherichia coli; Mus musculus mus musculus mus musculus escherichia coli Hirose, T., Katagiri, S., Nogi, T. 3.2 X-RAY DIFFRACTION 0.289 0.243 False True IGHV1 IGKV5 Kappa None None None None None 7y9t D NA 0 B protein NA auxin efflux carrier component 1 TRANSPORT PROTEIN 09/07/22 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the apo state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y9t C NA 0 A protein NA auxin efflux carrier component 1 TRANSPORT PROTEIN 09/07/22 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the apo state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y9u C NA 0 A protein NA auxin efflux carrier component 1 TRANSPORT PROTEIN 09/07/22 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the NPA-bound state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y9u D NA 0 B protein NA auxin efflux carrier component 1 TRANSPORT PROTEIN 09/07/22 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the NPA-bound state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y9v C NA 0 A protein NA auxin efflux carrier component 1 TRANSPORT PROTEIN 09/07/22 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the IAA-bound state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7y9v D NA 0 B protein NA auxin efflux carrier component 1 TRANSPORT PROTEIN 09/07/22 Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the IAA-bound state Arabidopsis thaliana; Escherichia coli arabidopsis thaliana Sun, L., Liu, X., Yang, Z., Xia, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7xw6 Y L 0 R protein NA thyrotropin receptor MEMBRANE PROTEIN 08/17/22 TSHR-Gs-M22 antibody-ML109 complex Homo sapiens; Mus musculus homo sapiens mus musculus homo sapiens Duan, J., Xu, P., Luan, X., Ji, Y., Yuan, Q., He, X., Ye, J., Cheng, X., Jiang, H., Zhang, S., Jiang, Y., Xu, H.E. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 7xw6 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/17/22 TSHR-Gs-M22 antibody-ML109 complex Homo sapiens; Mus musculus homo sapiens homo sapiens | homo sapiens Duan, J., Xu, P., Luan, X., Ji, Y., Yuan, Q., He, X., Ye, J., Cheng, X., Jiang, H., Zhang, S., Jiang, Y., Xu, H.E. 2.78 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ukt E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS4.2 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.36994 X-RAY DIFFRACTION 0.218 0.194 False True IGHV14 IGKV14 Kappa None None None None None 7ukt H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS4.2 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.36994 X-RAY DIFFRACTION 0.218 0.194 False True IGHV14 IGKV14 Kappa None None None None None 7ukp E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with a gantofiban analog Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.80113 X-RAY DIFFRACTION 0.241 0.219 False True IGHV14 IGKV14 Kappa None None None None None 7ukp H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with a gantofiban analog Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.80113 X-RAY DIFFRACTION 0.241 0.219 False True IGHV14 IGKV14 Kappa None None None None None 7uko E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with sibrafiban (Mn) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.604 X-RAY DIFFRACTION 0.239 0.214 False True IGHV14 IGKV14 Kappa None None None None None 7uko H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with sibrafiban (Mn) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.604 X-RAY DIFFRACTION 0.239 0.214 False True IGHV14 IGKV14 Kappa None None None None None 7uk9 E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with lamifiban (Mn) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.60002 X-RAY DIFFRACTION 0.242 0.223 False True IGHV14 IGKV14 Kappa None None None None None 7uk9 H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with lamifiban (Mn) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.60002 X-RAY DIFFRACTION 0.242 0.223 False True IGHV14 IGKV14 Kappa None None None None None 7ujk E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with lamifiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.43266 X-RAY DIFFRACTION 0.247 0.221 False True IGHV14 IGKV14 Kappa None None None None None 7ujk H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with lamifiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.43266 X-RAY DIFFRACTION 0.247 0.221 False True IGHV14 IGKV14 Kappa None None None None None 7uje E F 0 C protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with UR2922 in Mn2+ Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.49997 X-RAY DIFFRACTION 0.239 0.209 False False IGHV14 IGKV14 Kappa None None None None None 7uje H L 0 A protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with UR2922 in Mn2+ Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.49997 X-RAY DIFFRACTION 0.239 0.209 False False IGHV14 IGKV14 Kappa None None None None None 7uh8 E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with roxifiban (Mn/Ca) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.75002 X-RAY DIFFRACTION 0.248 0.229 False True IGHV14 IGKV14 Kappa None None None None None 7uh8 H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with roxifiban (Mn/Ca) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.75002 X-RAY DIFFRACTION 0.248 0.229 False True IGHV14 IGKV14 Kappa None None None None None 7ufh E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with fradafiban (Mn/Ca) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.99768 X-RAY DIFFRACTION 0.245 0.225 False True IGHV14 IGKV14 Kappa None None None None None 7ufh H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with fradafiban (Mn/Ca) Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.99768 X-RAY DIFFRACTION 0.245 0.225 False True IGHV14 IGKV14 Kappa None None None None None 7ue0 E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with fradafiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.74196 X-RAY DIFFRACTION 0.253 0.225 False True IGHV14 IGKV14 Kappa None None None None None 7ue0 H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with fradafiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.74196 X-RAY DIFFRACTION 0.253 0.225 False True IGHV14 IGKV14 Kappa None None None None None 7udh E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS4-3 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 1.99999 X-RAY DIFFRACTION 0.214 0.185 False True IGHV14 IGKV14 Kappa None None None None None 7udh H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS4-3 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 1.99999 X-RAY DIFFRACTION 0.214 0.185 False True IGHV14 IGKV14 Kappa None None None None None 7udg E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with lotrafiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.80007 X-RAY DIFFRACTION 0.235 0.213 False True IGHV14 IGKV14 Kappa None None None None None 7udg H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with lotrafiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.80007 X-RAY DIFFRACTION 0.235 0.213 False True IGHV14 IGKV14 Kappa None None None None None 7ucy E F 0 C protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with gantofiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.34996 X-RAY DIFFRACTION 0.231 0.221 False True IGHV14 IGKV14 Kappa None None None None None 7ucy H L 0 A protein NA integrin alpha-iib heavy chain CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with gantofiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.34996 X-RAY DIFFRACTION 0.231 0.221 False True IGHV14 IGKV14 Kappa None None None None None 7ubr E F 0 C protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with GR144053 Homo sapiens homo sapiens homo sapiens homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.04993 X-RAY DIFFRACTION 0.223 0.209 False True IGHV14 IGKV14 Kappa None None None None None 7ubr H L 0 A protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with GR144053 Homo sapiens homo sapiens homo sapiens homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.04993 X-RAY DIFFRACTION 0.223 0.209 False True IGHV14 IGKV14 Kappa None None None None None 7u9v E F 0 C protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS4-1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.25492 X-RAY DIFFRACTION 0.226 0.203 False True IGHV14 IGKV14 Kappa None None None None None 7u9v H L 0 A protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS4-1 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.25492 X-RAY DIFFRACTION 0.226 0.203 False True IGHV14 IGKV14 Kappa None None None None None 7u9f E F 0 C protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS compound 4 in Mn2+ Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.70001 X-RAY DIFFRACTION 0.237 0.217 False False IGHV14 IGKV14 Kappa None None None None None 7u9f H L 0 A protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS compound 4 in Mn2+ Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Zhu, J., Springer, T.A. 2.70001 X-RAY DIFFRACTION 0.237 0.217 False False IGHV14 IGKV14 Kappa None None None None None 7u60 E F 0 C protein NA integrin alpha-iib CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with cRGDfV Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J., Lin, F.Y., Zhu, J., Springer, T.A. 2.55 X-RAY DIFFRACTION 0.225 0.188 False False IGHV14 IGKV14 Kappa None None None None None 7u60 H L 0 A protein NA integrin alpha-iib CELL ADHESION/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with cRGDfV Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J., Lin, F.Y., Zhu, J., Springer, T.A. 2.55 X-RAY DIFFRACTION 0.225 0.188 False False IGHV14 IGKV14 Kappa None None None None None 7tpd E F 0 C protein NA integrin alpha-iib heavy chain BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with EF5154 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.6 X-RAY DIFFRACTION 0.194 0.165 False False IGHV14 IGKV14 Kappa None None None None None 7tpd H L 0 A protein NA integrin alpha-iib heavy chain BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with EF5154 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.6 X-RAY DIFFRACTION 0.194 0.165 False False IGHV14 IGKV14 Kappa None None None None None 7tmz E F 0 C protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS compound 4 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.20002 X-RAY DIFFRACTION 0.241 0.214 False False IGHV14 IGKV14 Kappa None None None None None 7tmz H L 0 A protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with BMS compound 4 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.20002 X-RAY DIFFRACTION 0.241 0.214 False False IGHV14 IGKV14 Kappa None None None None None 7tho E F 0 C protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with Eptifibatide Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.75 X-RAY DIFFRACTION 0.222 0.189 False False IGHV14 IGKV14 Kappa None None None None None 7tho H L 0 A protein NA integrin alpha-iib BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with Eptifibatide Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.75 X-RAY DIFFRACTION 0.222 0.189 False False IGHV14 IGKV14 Kappa None None None None None 7td8 E F 0 C protein NA integrin alpha-iib BLOOD CLOTTING 08/17/22 Integrin alaphIIBbeta3 complex with Tirofiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.6 X-RAY DIFFRACTION 0.210 0.182 False False IGHV14 IGKV14 Kappa None None None None None 7td8 H L 0 A protein NA integrin alpha-iib BLOOD CLOTTING 08/17/22 Integrin alaphIIBbeta3 complex with Tirofiban Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.6 X-RAY DIFFRACTION 0.210 0.182 False False IGHV14 IGKV14 Kappa None None None None None 7tct E F 0 C protein NA integrin alpha-iib heavy chain BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with UR2922 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.501 X-RAY DIFFRACTION 0.227 0.195 False False IGHV14 IGKV14 Kappa None None None None None 7tct H L 0 A protein NA integrin alpha-iib heavy chain BLOOD CLOTTING/INHIBITOR 08/17/22 Integrin alaphIIBbeta3 complex with UR2922 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, J., Lin, F.-Y., Zhu, J., Springer, T.A. 2.501 X-RAY DIFFRACTION 0.227 0.195 False False IGHV14 IGKV14 Kappa None None None None None 7xw5 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 TSHR-thyroid stimulating hormone-Gs-ML109 complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Duan, J., Xu, P., Luan, X., Ji, Y., Yuan, Q., He, X., Ye, J., Cheng, X., Jiang, H., Zhang, S., Jiang, Y., Xu, H.E. 2.96 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ph7 C NA 0 B protein NA atp-binding transport protein multicopy suppressor of htrb MEMBRANE PROTEIN 08/24/22 Nanodisc reconstituted MsbA in complex with nanobodies, spin-labeled at position T68C Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Parey, K., Januliene, D., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ph7 D NA 0 A protein NA atp-binding transport protein multicopy suppressor of htrb MEMBRANE PROTEIN 08/24/22 Nanodisc reconstituted MsbA in complex with nanobodies, spin-labeled at position T68C Escherichia coli; Vicugna pacos vicugna pacos escherichia coli Parey, K., Januliene, D., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ph2 C NA 0 B protein NA atp-dependent lipid a-core flippase MEMBRANE PROTEIN 08/24/22 Nanodisc reconstituted MsbA in complex with nanobodies, spin-labeled at position A60C Escherichia coli K-12; Vicugna pacos vicugna pacos escherichia coli k-12 Januliene, D., Parey, K., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ph2 D NA 0 A protein NA atp-dependent lipid a-core flippase MEMBRANE PROTEIN 08/24/22 Nanodisc reconstituted MsbA in complex with nanobodies, spin-labeled at position A60C Escherichia coli K-12; Vicugna pacos vicugna pacos escherichia coli k-12 Januliene, D., Parey, K., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dlx H NA 0 C | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 01/08/09 Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with VH ab6 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xz5 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 08/24/22 GPR119-Gs-LPC complex Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Xu, P., Huang, S., Jiang, Y., Xu, H.E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7y7m F G 0 C | B protein | protein NA | NA capsid protein vp3 | capsid protein vp2 VIRUS 08/24/22 The structure of coxsackievirus A16 mature virion in complex with Fab 8C4 Coxsackievirus A16 coxsackievirus a16 coxsackievirus a16 coxsackievirus a16 | coxsackievirus a16 Cong, Y., Liu, C.X. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 8dlz H NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/08/09 Cryo-EM structure of SARS-CoV-2 D614G spike protein in complex with VH ab6 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ph3 C NA 0 B protein NA atp-dependent lipid a-core flippase MEMBRANE PROTEIN 08/24/22 AMP-PNP bound nanodisc reconstituted MsbA with nanobodies, spin-labeled at position A60C Escherichia coli K-12; Vicugna pacos vicugna pacos escherichia coli k-12 Parey, K., Januliene, D., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ph3 D NA 0 A protein NA atp-dependent lipid a-core flippase MEMBRANE PROTEIN 08/24/22 AMP-PNP bound nanodisc reconstituted MsbA with nanobodies, spin-labeled at position A60C Escherichia coli K-12; Vicugna pacos vicugna pacos escherichia coli k-12 Parey, K., Januliene, D., Galazzo, L., Meier, G., Vecchis, D., Striednig, B., Hilbi, H., Schaefer, L.V., Kuprov, I., Bordignon, E., Seeger, M.A., Moeller, A. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7u0y H L 0 R nucleic-acid NA rna aptamer IMMUNE SYSTEM/RNA 08/31/22 Crystal structure of Pepper RNA aptamer in complex with HBC599 ligand and Fab BL3-6 Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Rees, H.C., Piccirilli, J.A. 2.66 X-RAY DIFFRACTION 0.255 0.219 False True IGHV3 IGKV1 Kappa None None None None None 7v8q B A 0 G peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 Glycopeptide(GlycoT) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 3.2 X-RAY DIFFRACTION 0.244 0.200 False True IGHV4 IGLV1 Lambda None None None None None 7v8q D C 0 H peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 Glycopeptide(GlycoT) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 3.2 X-RAY DIFFRACTION 0.244 0.200 False True IGHV4 IGLV1 Lambda None None None None None 7v8q F E 0 I peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 Glycopeptide(GlycoT) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 3.2 X-RAY DIFFRACTION 0.244 0.200 False True IGHV4 IGLV1 Lambda None None None None None 7vac B A 0 G peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoST) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 3.5 X-RAY DIFFRACTION 0.219 0.171 False True IGHV4 IGLV1 Lambda None None None None None 7vac D C 0 H peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoST) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 3.5 X-RAY DIFFRACTION 0.219 0.171 False True IGHV4 IGLV1 Lambda None None None None None 7vac F E 0 I peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoST) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 3.5 X-RAY DIFFRACTION 0.219 0.171 False True IGHV4 IGLV1 Lambda None None None None None 7vaz D C 0 G peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoS) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 2.73 X-RAY DIFFRACTION 0.264 0.209 False True IGHV4 IGLV1 Lambda None None None None None 7vaz B A 0 E peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoS) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 2.73 X-RAY DIFFRACTION 0.264 0.209 False True IGHV4 IGLV1 Lambda None None None None None 7vaz H F 0 I peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/31/22 Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoS) Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 2.73 X-RAY DIFFRACTION 0.264 0.209 False True IGHV4 IGLV1 Lambda None None None None None 7wbz H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Crystal structure of the SARS-Cov-2 RBD in complex with Fab 2303 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Ma, B. 2.42 X-RAY DIFFRACTION 0.220 0.182 False True IGHV3 IGKV1 Kappa None None None None None 7x1t D d 0 B | C protein | protein NA | NA mini-g alpha q protein | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/31/22 Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin. Bos taurus; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT rattus norvegicus homo sapiens | bos taurus Yang, F., Zhang, H.H., Meng, X.Y., Li, Y.G., Zhou, Y.X., Ling, S.L., Liu, L., Shi, P., Tian, C.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7x1u D d 0 B | F | C protein | peptide | protein NA | NA | NA mini-g alpha q prtoein | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/31/22 Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH. Bos taurus; Homo sapiens; Rattus norvegicus; SYNTHETIC CONSTRUCT rattus norvegicus homo sapiens | bos taurus | bos taurus Yang, F., Zhang, H.H., Meng, X.Y., Li, Y.G., Zhou, Y.X., Ling, S.L., Liu, L., Shi, P., Tian, C.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xat E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/31/22 Structure of somatostatin receptor 2 bound with SST14. Bos taurus; Homo sapiens; Rattus; synthetic construct; SYNTHETIC CONSTRUCT rattus homo sapiens | bos taurus Bo, Q., Yang, F., Li, Y.G., Meng, X.Y., Zhang, H.H., Zhou, Y.X., Ling, S.L., Sun, D.M., Lv, P., Liu, L., Shi, P., Tian, C.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xau E e 0 B | D | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/31/22 Structure of somatostatin receptor 2 bound with octreotide. Bos taurus; Homo sapiens; Rattus; synthetic construct; SYNTHETIC CONSTRUCT rattus homo sapiens | bos taurus | bos taurus Bo, Q., Yang, F., Li, Y.G., Meng, X.Y., Zhang, H.H., Zhou, Y.X., Ling, S.L., Sun, D.M., Lv, P., Liu, L., Shi, P., Tian, C.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xav E e 0 B | D | C protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/31/22 Structure of somatostatin receptor 2 bound with lanreotide. Bos taurus; Homo sapiens; Rattus; synthetic construct; SYNTHETIC CONSTRUCT rattus homo sapiens | bos taurus | bos taurus Bo, Q., Yang, F., Li, Y.G., Meng, X.Y., Zhang, H.H., Zhou, Y.X., Ling, S.L., Sun, D.M., Lv, P., Liu, L., Shi, P., Tian, C.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xck A B 0 M protein NA spike protein s1 VIRAL PROTEIN 08/31/22 Cryo-EM structure of SARS-CoV-2 Omicron RBD in complex with S309 fab (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, G.F., Qi, J.X., Zhao, Z.N., Xie, Y.F., Liu, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7xcp H L 0 B protein NA spike protein s1 VIRAL PROTEIN 08/31/22 Cryo-EM structure of Omicron RBD complexed with ACE2 and 304 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, Z., Qi, J., Gao, F.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xz6 N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 GPR119-Gs-APD668 complex Escherichia coli; Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Xu, P., Huang, S., Jiang, Y., Xu, H.E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yad A B 0 M protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/31/22 Cryo-EM structure of S309-RBD-RBD-S309 in the S309-bound Omicron spike protein (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, Z.N., Xie, Y.F., Qi, J.X., Gao, F. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7yad C D 0 E protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/31/22 Cryo-EM structure of S309-RBD-RBD-S309 in the S309-bound Omicron spike protein (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhao, Z.N., Xie, Y.F., Qi, J.X., Gao, F. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7ydi H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2, focused refinement of RBD region Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 3.98 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7ydy H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 1 R1-32 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 4.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7ye5 H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 2 R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 6.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7ye9 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7ye9 G I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7ye9 N O 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 4.17 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7yeg H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7yeg G I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7yeg N O 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, B., Gao, X., Li, Z., Chen, X., He, J., Chen, L., Xiong, X. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7yms F E 0 A protein NA capsid protein vp1 VIRUS 08/24/22 Cryo-EM structure of Coxsackievirus A16 in complex with a neutralizing antibody 9B5 Coxsackievirus A16 coxsackievirus a16 coxsackievirus a16 coxsackievirus a16 Cong, Y., Liu, C.X. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7yp7 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 apo-ADGRG2 coupled to Gs Homo sapiens; Lama glama; Mus musculus lama glama homo sapiens | homo sapiens Liu, Z.M., Bu, R.Q., Xue, C.Y., Guo, S.C., Yuan, D.P., Xiao, P., Sun, J.P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7yz9 B NA 0 A protein NA adenylate cyclase SIGNALING PROTEIN 08/31/22 Structure of catalytic domain of Rv1625c bound to nanobody NB4 Mycobacterium tuberculosis H37Rv; Vicugna pacos vicugna pacos mycobacterium tuberculosis h37rv Khanppnavar, B., Mehta, V.J., Iype, T., Korkhov, V.M. 1.97 X-RAY DIFFRACTION 0.244 0.206 False True IGHV1 NA NA None None None None None 7yzk C NA 0 B protein NA adenylate cyclase MEMBRANE PROTEIN 08/31/22 Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya Mycobacterium tuberculosis; Vicugna pacos vicugna pacos mycobacterium tuberculosis Mehta, V., Khanppnavar, B., Korkhov, V.M. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7yzk D NA 0 A protein NA adenylate cyclase MEMBRANE PROTEIN 08/31/22 Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya Mycobacterium tuberculosis; Vicugna pacos vicugna pacos mycobacterium tuberculosis Mehta, V., Khanppnavar, B., Korkhov, V.M. 3.57 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7zk1 B NA 0 A protein NA cystinosin homolog MEMBRANE PROTEIN 08/31/22 Crystal structure of cystinosin from Arabidopsis thaliana bound to sybody and nanobody Arabidopsis thaliana; Lama glama; synthetic construct lama glama arabidopsis thaliana Loebel, M., Newstead, S., Omari, K.E. 2.65 X-RAY DIFFRACTION 0.270 0.230 False True IGHV1 NA NA None None None None None 7zk1 C NA 0 A protein NA cystinosin homolog MEMBRANE PROTEIN 08/31/22 Crystal structure of cystinosin from Arabidopsis thaliana bound to sybody and nanobody Arabidopsis thaliana; Lama glama; synthetic construct synthetic construct arabidopsis thaliana Loebel, M., Newstead, S., Omari, K.E. 2.65 X-RAY DIFFRACTION 0.270 0.230 False True IGHV1 NA NA None None None None None 7zkw C NA 0 A protein NA cystinosin homolog MEMBRANE PROTEIN 08/31/22 Crystal structure of cystinosin from Arabidopsis thaliana in complex with Cystine and sybody Arabidopsis thaliana; synthetic construct synthetic construct arabidopsis thaliana Parker, J.L., Loebel, M., Newstead, S. 3.372 X-RAY DIFFRACTION 0.280 0.250 False True IGHV1 NA NA None None None None None 7zkw D NA 0 B protein NA cystinosin homolog MEMBRANE PROTEIN 08/31/22 Crystal structure of cystinosin from Arabidopsis thaliana in complex with Cystine and sybody Arabidopsis thaliana; synthetic construct synthetic construct arabidopsis thaliana Parker, J.L., Loebel, M., Newstead, S. 3.372 X-RAY DIFFRACTION 0.280 0.250 False True IGHV1 NA NA None None None None None 7zkz B NA 0 A protein NA cystinosin homolog MEMBRANE PROTEIN 08/31/22 Crystal structure of cystinosin from Arabidopsis thaliana bound to two nanobodies Arabidopsis thaliana; Lama glama lama glama arabidopsis thaliana Loebel, M., Newstead, S. 2.329 X-RAY DIFFRACTION 0.265 0.235 False True IGHV1 NA NA None None None None None 7zkz C NA 0 A protein NA cystinosin homolog MEMBRANE PROTEIN 08/31/22 Crystal structure of cystinosin from Arabidopsis thaliana bound to two nanobodies Arabidopsis thaliana; Lama glama lama glama arabidopsis thaliana Loebel, M., Newstead, S. 2.329 X-RAY DIFFRACTION 0.265 0.235 False True IGHV1 NA NA None None None None None 8dad H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 SARS-CoV-2 receptor binding domain in complex with AZ090 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zong, S., Wang, Z., Gaebler, C., Nussenzweig, M. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8di5 H NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/22 Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with VH domain F6 (focused refinement of RBD and VH F6) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Saville, J.W., Mannar, D., Berezuk, A.M., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dlr H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/31/22 Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with Fab 4-8 (focused refinement of NTD and 4-8) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 8dls H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/31/22 Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with Fab 4A8 (focused refinement of NTD and 4A8) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 8dlw C D 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/31/22 Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with Fab S2M11 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dlw F G 0 E protein NA spike glycoprotein VIRAL PROTEIN 08/31/22 Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with Fab S2M11 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dlw H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/31/22 Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with Fab S2M11 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 8dly H NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with VH ab6 (focused refinement of NTD and VH ab6) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dm0 H NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Cryo-EM structure of SARS-CoV-2 D614G spike protein in complex with VH ab6 (focused refinement of NTD and VH ab6) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Saville, J.W., Srivastava, S.S., Berezuk, A.M., Zhou, S., Tuttle, K.S., Subramaniam, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dpf E e 0 B | C protein | protein NA | NA g-alpha subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to lorcaserin Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpg E e 0 B | C protein | protein NA | NA g-alpha subunit q (gi2-mini-gq chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to psilocin Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dph E e 0 B | C protein | protein NA | NA g-alpha subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 Cryo-EM structure of the 5HT2C receptor (VGV isoform) bound to lorcaserin Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dpi E e 0 B | C protein | protein NA | NA g-alpha subunit q (gi2-mini-gq chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/24/22 Cryo-EM structure of the 5HT2C receptor (VSV isoform) bound to lorcaserin Homo sapiens homo sapiens homo sapiens | homo sapiens Gumpper, R.H., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8dzh E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Structure of SARS-CoV-2 Omicron BA.1.1.529 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody MB.02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8dzh H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Structure of SARS-CoV-2 Omicron BA.1.1.529 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody MB.02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8dzh I J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Structure of SARS-CoV-2 Omicron BA.1.1.529 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody MB.02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8dzi H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Structure of SARS-CoV-2 Omicron BA.1.1.529 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody MB.02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8dzi B D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Structure of SARS-CoV-2 Omicron BA.1.1.529 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody MB.02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8dzi G F 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/31/22 Structure of SARS-CoV-2 Omicron BA.1.1.529 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody MB.02 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 8dd3 J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, S., Hibbs, R.E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8dd3 K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, S., Hibbs, R.E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 7uce H L 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment Homo sapiens homo sapiens homo sapiens Barnes, C.O., Bjorkman, P.J. 2.25 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 IGLV2 Lambda None None None None None 7ucf D E 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4 X-RAY DIFFRACTION 0.277 0.246 False True IGHV1 IGLV2 Lambda None None None None None 7ucf H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4 X-RAY DIFFRACTION 0.277 0.246 False True IGHV4 unknown unknown None None None None None 7ucg D E 0 G protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ucg H L 0 G protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7ucg C F 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ucg J K 0 I protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7ucg N O 0 P protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ucg Q R 0 P protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 unknown unknown None None None None None 7usl H L 0 C protein NA bifunctional hemolysin-adenylate cyclase TOXIN 08/17/22 Integrin alphaM/beta2 ectodomain in complex with adenylate cyclase toxin RTX751 and M1F5 Fab Bordetella pertussis; Homo sapiens homo sapiens homo sapiens bordetella pertussis Goldsmith, J.A., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 7v3l D E 0 A protein NA spike glycoprotein PROTEIN BINDING 08/17/22 MERS S ectodomain trimer in complex with neutralizing antibody 6516 Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Wang, Y., Zeng, J. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v3l F G 0 B protein NA spike glycoprotein PROTEIN BINDING 08/17/22 MERS S ectodomain trimer in complex with neutralizing antibody 6516 Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Wang, Y., Zeng, J. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v3l H I 0 C protein NA spike glycoprotein PROTEIN BINDING 08/17/22 MERS S ectodomain trimer in complex with neutralizing antibody 6516 Homo sapiens; Human betacoronavirus 2c EMC/2012 homo sapiens homo sapiens human betacoronavirus 2c emc/2012 Wang, X., Zhao, J., Wang, Z., Wang, Y., Zeng, J. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v3q B A 0 NA NA NA NA IMMUNE SYSTEM 08/17/22 Crystal structure of anti-MUC1 antibody 16A Mus musculus mus musculus mus musculus Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 2.98 X-RAY DIFFRACTION 0.264 0.218 False True IGHV4 IGLV1 Lambda None None None None None 7v3q D C 0 NA NA NA NA IMMUNE SYSTEM 08/17/22 Crystal structure of anti-MUC1 antibody 16A Mus musculus mus musculus mus musculus Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 2.98 X-RAY DIFFRACTION 0.264 0.218 False True IGHV4 IGLV1 Lambda None None None None None 7v4w B A 0 C peptide NA mucin-1 subunit alpha IMMUNE SYSTEM 08/17/22 Crystal structure of Antibody 16A in complex with MUC1 peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Niu, J., Xu, L., Meng, B., Han, Y.B., Yang, B. 2.1 X-RAY DIFFRACTION 0.233 0.180 False True IGHV4 IGLV1 Lambda None None None None None 7wm0 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 08/17/22 Cryo-EM structure of the Omicron RBD in complex with 35B5 Fab( local refinement of the RBD and 35B5 Fab) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, Y. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7wu9 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/17/22 The structure of the GPCR-G-protein complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Suno, R., Sugita, Y., Morimoto, K., Iwasaki, K., Kato, T., Kobayashi, T. 3.375 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7x7t H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV-2 spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Liu, L., Zheng, Q., Li, S., Zhang, T., Xia, N. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7x7t A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV-2 spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Liu, L., Zheng, Q., Li, S., Zhang, T., Xia, N. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x7t C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV-2 spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Liu, L., Zheng, Q., Li, S., Zhang, T., Xia, N. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV13 Kappa None None None None None 7x7u H L 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV-2 Delta variant spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Liu, L., Zhang, T., Zheng, Q., Li, S., Xia, N. 3.77 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7x7u A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV-2 Delta variant spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Liu, L., Zhang, T., Zheng, Q., Li, S., Xia, N. 3.77 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x7u C D 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV-2 Delta variant spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, H., Liu, L., Zhang, T., Zheng, Q., Li, S., Xia, N. 3.77 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV13 Kappa None None None None None 7x7v H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus mus musculus mus musculus severe acute respiratory syndrome coronavirus Sun, H., Liu, L., Zhang, T., Zheng, Q., Li, S., Xia, N. 3.83 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7x7v A F 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus mus musculus mus musculus severe acute respiratory syndrome coronavirus Sun, H., Liu, L., Zhang, T., Zheng, Q., Li, S., Xia, N. 3.83 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV10 Kappa None None None None None 7x7v C D 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of SARS-CoV spike protein in complex with three nAbs X01, X10 and X17 Mus musculus; Severe acute respiratory syndrome coronavirus mus musculus mus musculus severe acute respiratory syndrome coronavirus Sun, H., Liu, L., Zhang, T., Zheng, Q., Li, S., Xia, N. 3.83 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV13 Kappa None None None None None 7xq8 C L 0 NA NA NA NA SIGNALING PROTEIN 08/17/22 Structure of human B-cell antigen receptor of the IgM isotype Homo sapiens homo sapiens homo sapiens Chen, M.Y., Su, Q., Shi, Y.G. 0 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7xq8 v R 0 NA NA NA NA SIGNALING PROTEIN 08/17/22 Structure of human B-cell antigen receptor of the IgM isotype Homo sapiens homo sapiens homo sapiens Chen, M.Y., Su, Q., Shi, Y.G. 0 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7xw7 A B 0 R protein NA thyrotropin receptor MEMBRANE PROTEIN 08/17/22 TSHR-K1-70 complex Homo sapiens homo sapiens homo sapiens homo sapiens Duan, J., Xu, P., Luan, X., Ji, Y., Yuan, Q., He, X., Ye, J., Cheng, X., Jiang, H., Zhang, S., Jiang, Y., Xu, H.E. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 7y3j H L 0 A peptide NA ala-leu-val-phe-phe-ala-pro-ala-val-gly-ser IMMUNE SYSTEM 08/17/22 24B3 antibody-peptide complex Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Irie, K., Irie, Y., Kita, A., Miki, K. 2.6 X-RAY DIFFRACTION 0.261 0.222 False False IGHV1 IGKV1 Kappa None None None None None 7yhk F H 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/17/22 Cryo-EM structure of the HA trimer of A/Beijing/262/1995(H1N1) in complex with neutralizing antibody 12H5 Influenza A virus (A/Beijing/262/1995(H1N1)); Mus musculus mus musculus mus musculus influenza a virus (a/beijing/262/1995(h1n1)) Zheng, Q., Li, S., Li, T., Xue, W., Sun, H. 3.14 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV3 Kappa None None None None None 7zbu H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/17/22 CryoEM structure of SARS-CoV-2 spike monomer in complex with neutralising antibody P008_60 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rosa, A., Pye, V.E., Cronin, N., Cherepanov, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8a1e D E 0 A protein NA glycoprotein VIRAL PROTEIN 08/17/22 Rabies virus glycoprotein in complex with Fab fragments of 17C7 and 1112-1 neutralizing antibodies Homo sapiens; Mus musculus; Rabies virus strain Pasteur vaccin homo sapiens homo sapiens rabies virus strain pasteur vaccin Ng, W.M., Fedosyuk, S., English, S., Augusto, G., Berg, A., Thorley, L., Haselon, A.S., Segireddy, R.R., Bowden, T.A., Douglas, A.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 8a1e B C 0 A protein NA glycoprotein VIRAL PROTEIN 08/17/22 Rabies virus glycoprotein in complex with Fab fragments of 17C7 and 1112-1 neutralizing antibodies Homo sapiens; Mus musculus; Rabies virus strain Pasteur vaccin mus musculus mus musculus rabies virus strain pasteur vaccin Ng, W.M., Fedosyuk, S., English, S., Augusto, G., Berg, A., Thorley, L., Haselon, A.S., Segireddy, R.R., Bowden, T.A., Douglas, A.D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 8dd2 J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/17/22 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, S., Hibbs, R.E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 8dd2 K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/17/22 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Zhu, S., Hibbs, R.E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 7upl E D 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 SARS-Cov2 Omicron varient S protein structure in complex with neutralizing monoclonal antibody 002-S21F2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7upl F I 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 SARS-Cov2 Omicron varient S protein structure in complex with neutralizing monoclonal antibody 002-S21F2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7nbb D NA 0 A | C | B protein | protein | protein NA | NA | NA polyubiquitin-b | polyubiquitin-b | polyubiquitin-b SIGNALING PROTEIN 08/10/22 Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with synthetic nanobody NbSL3 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Lange, S.M., Kulathu, Y. 1.55 X-RAY DIFFRACTION 0.212 0.175 False True IGHV1 NA NA None None None None None 7nbb H NA 0 E | F | G protein | protein | protein NA | NA | NA polyubiquitin-b | polyubiquitin-b | polyubiquitin-b SIGNALING PROTEIN 08/10/22 Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with synthetic nanobody NbSL3 Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Lange, S.M., Kulathu, Y. 1.55 X-RAY DIFFRACTION 0.212 0.175 False True IGHV1 NA NA None None None None None 7u0p E F 0 C protein NA spike glycoprotein VIRAL PROTEIN 01/08/09 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21F2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7u0p D I 0 B protein NA spike glycoprotein VIRAL PROTEIN 01/08/09 SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21F2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Patel, A., Ortlund, E. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7z3a G I 0 F protein NA amc009 sosip.v5.2 envelope glycoprotein gp41 VIRAL PROTEIN 01/08/09 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 7z3a H L 0 D protein NA amc009 sosipv5.2 envelope glycoprotein gp120 VIRAL PROTEIN 01/08/09 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7z3a M O 0 B protein NA amc009 sosip.v5.2 envelope glycoprotein gp41 VIRAL PROTEIN 01/08/09 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 7z3a J N 0 A protein NA amc009 sosipv5.2 envelope glycoprotein gp120 VIRAL PROTEIN 01/08/09 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7z3a K P 0 C protein NA amc009 sosipv5.2 envelope glycoprotein gp120 VIRAL PROTEIN 01/08/09 AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124 Homo sapiens; Human immunodeficiency virus 1 homo sapiens homo sapiens human immunodeficiency virus 1 van Schooten, J., Ward, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7fjc H L 0 E protein NA spike protein s1 VIRAL PROTEIN 08/10/22 Crystal structure of SARS-CoV-2 Beta RBD complexed with P36-5D2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, L.Q., Wang, X.Q., Shan, S.S., Lan, J. 2.96 X-RAY DIFFRACTION 0.269 0.212 False True IGHV1 IGKV1 Kappa None None None None None 7qvm S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha,cdnaflj31446 fis, clone nt2ne2000909, highly similar to guanine nucleotide-binding protein g(o) subunit alpha 1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/10/22 Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Waltenspuhl, Y., Ehrenmann, J., Vacca, S., Thom, C., Medalia, O., Pluckthun, A. 3.25 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7sbd H L 0 C protein NA profilin-2 ALLERGEN/IMMUNE SYSTEM 08/10/22 Murine Fab/IgE in complex with profilin from Hevea brasieliensis (Hev b 8) Hevea brasiliensis; Mus musculus mus musculus mus musculus hevea brasiliensis Rodriguez-Romero, A., Garcia-Ramirez, B. 3.04 X-RAY DIFFRACTION 0.254 0.228 False False IGHV10 IGKV12 Kappa None None None None None 7sbg H L 0 C protein NA profilin-2 ALLERGEN/IMMUNE SYSTEM 08/10/22 Murine Fab/IgE in complex with profilin from Hevea brasieliensis (Hev b 8) Hevea brasiliensis; Mus musculus mus musculus mus musculus hevea brasiliensis Rodriguez-Romero, A., Garcia-Ramirez, B. 3.34 X-RAY DIFFRACTION 0.298 0.245 False False IGHV10 IGKV12 Kappa None None None None None 7sd2 H L 0 NA NA NA NA IMMUNE SYSTEM 08/10/22 Murine Fab that recognizes Hev b 8 (profilin for Hevea brasiliensis) Mus musculus mus musculus mus musculus Rodriguez-Romero, A., Garcia-Ramirez, B. 3.75 X-RAY DIFFRACTION 0.284 0.247 False False IGHV10 IGKV12 Kappa None None None None None 7sd2 A B 0 NA NA NA NA IMMUNE SYSTEM 08/10/22 Murine Fab that recognizes Hev b 8 (profilin for Hevea brasiliensis) Mus musculus mus musculus mus musculus Rodriguez-Romero, A., Garcia-Ramirez, B. 3.75 X-RAY DIFFRACTION 0.284 0.247 False False IGHV10 IGKV12 Kappa None None None None None 7sd2 C D 0 NA NA NA NA IMMUNE SYSTEM 08/10/22 Murine Fab that recognizes Hev b 8 (profilin for Hevea brasiliensis) Mus musculus mus musculus mus musculus Rodriguez-Romero, A., Garcia-Ramirez, B. 3.75 X-RAY DIFFRACTION 0.284 0.247 False False IGHV10 IGKV12 Kappa None None None None None 7str H L 0 C protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/10/22 Crystal Structure of Human Fab S24-1063 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 1.5 X-RAY DIFFRACTION 0.202 0.161 False True IGHV4 IGKV3 Kappa None None None None None 7sts A B 0 D protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/10/22 Crystal Structure of Human Fab S24-1379 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 2.16 X-RAY DIFFRACTION 0.209 0.190 False True IGHV4 IGLV1 Lambda None None None None None 7sts H L 0 C protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/10/22 Crystal Structure of Human Fab S24-1379 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 2.16 X-RAY DIFFRACTION 0.209 0.190 False True IGHV4 IGLV1 Lambda None None None None None 7sue H L 0 C protein NA nucleoprotein VIRAL PROTEIN 08/10/22 Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 2.9 X-RAY DIFFRACTION 0.292 0.262 False True IGHV1 IGLV2 Lambda None None None None None 7sue B A 0 D protein NA nucleoprotein VIRAL PROTEIN 08/10/22 Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 2.9 X-RAY DIFFRACTION 0.292 0.262 False True IGHV1 IGLV2 Lambda None None None None None 7sue F E 0 J protein NA nucleoprotein VIRAL PROTEIN 08/10/22 Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 2.9 X-RAY DIFFRACTION 0.292 0.262 False True IGHV1 IGLV2 Lambda None None None None None 7sue I G 0 K protein NA nucleoprotein VIRAL PROTEIN 08/10/22 Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 2.9 X-RAY DIFFRACTION 0.292 0.262 False True IGHV1 IGLV2 Lambda None None None None None 7t9m H L 0 R protein NA thyrotropin receptor MEMBRANE PROTEIN 08/10/22 Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Faust, B., Cheng, Y., Manglik, A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7unb H L 0 R protein NA gametocyte surface protein p45/48 IMMUNE SYSTEM 08/10/22 Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-117 and RUPA-47 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., McLeod, B., Julien, J.-P. 2.18 X-RAY DIFFRACTION 0.228 0.178 False True IGHV1 IGKV3 Kappa None None None None None 7unb F E 0 R protein NA gametocyte surface protein p45/48 IMMUNE SYSTEM 08/10/22 Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-117 and RUPA-47 Homo sapiens; Plasmodium falciparum homo sapiens homo sapiens plasmodium falciparum Hailemariam, S., McLeod, B., Julien, J.-P. 2.18 X-RAY DIFFRACTION 0.228 0.178 False True IGHV4 IGKV1 Kappa None None None None None 7upw D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus homo sapiens, mus musculus homo sapiens, mus musculus severe acute respiratory syndrome coronavirus Zhang, J., Luo, S., Kreutzberger, A., Kirchhausen, T., Chen, B., Haynes, B., Alt, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7upw F G 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus homo sapiens, mus musculus homo sapiens, mus musculus severe acute respiratory syndrome coronavirus Zhang, J., Luo, S., Kreutzberger, A., Kirchhausen, T., Chen, B., Haynes, B., Alt, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7upw H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus homo sapiens, mus musculus homo sapiens, mus musculus severe acute respiratory syndrome coronavirus Zhang, J., Luo, S., Kreutzberger, A., Kirchhausen, T., Chen, B., Haynes, B., Alt, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7upx H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains) Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus homo sapiens, mus musculus homo sapiens, mus musculus severe acute respiratory syndrome coronavirus Zhang, J., Luo, S., Kreutzberger, A., Kirchhausen, T., Chen, B., Haynes, B., Alt, F. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7upy H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 One RBD-up state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus homo sapiens, mus musculus homo sapiens, mus musculus severe acute respiratory syndrome coronavirus Zhang, J., Luo, S., Kreutzberger, A., Kirchhausen, T., Chen, B., Haynes, B., Alt, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7upy D E 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 One RBD-up state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus homo sapiens, mus musculus homo sapiens, mus musculus severe acute respiratory syndrome coronavirus Zhang, J., Luo, S., Kreutzberger, A., Kirchhausen, T., Chen, B., Haynes, B., Alt, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7upy F G 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 One RBD-up state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment Homo sapiens; Mus musculus; Severe acute respiratory syndrome coronavirus homo sapiens, mus musculus homo sapiens, mus musculus severe acute respiratory syndrome coronavirus Zhang, J., Luo, S., Kreutzberger, A., Kirchhausen, T., Chen, B., Haynes, B., Alt, F. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7v23 O P 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7v23 Q R 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7v23 S T 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7v24 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/10/22 Local CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7v27 B A 0 C protein NA spike protein s1 VIRAL PROTEIN 08/10/22 RBD/XG005 local refinement Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Sun, L., Chen, Z.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7voa A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 08/10/22 Crystal structure of SARS-CoV-2 RBD in complex with aRBD5 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Ma, H., Zeng, W.H., Jin, T.C. 1.8 X-RAY DIFFRACTION 0.226 0.186 False True IGHV1 NA NA None None None None None 7wc0 H L 0 NA NA NA NA IMMUNE SYSTEM 08/10/22 Crystal structure of Fab region of TAU-2212 neutralizing SARS-CoV-2 Homo sapiens homo sapiens homo sapiens Xiang, Y., Li, R., Ma, B. 2.705 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGLV2 Lambda None None None None None 7wc0 A B 0 NA NA NA NA IMMUNE SYSTEM 08/10/22 Crystal structure of Fab region of TAU-2212 neutralizing SARS-CoV-2 Homo sapiens homo sapiens homo sapiens Xiang, Y., Li, R., Ma, B. 2.705 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGLV2 Lambda None None None None None 7wcd E F 0 H protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/10/22 Cryo EM structure of SARS-CoV-2 spike in complex with TAU-2212 mAbs in conformation 4 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Ma, B., Li, R. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7wcd G I 0 J protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/10/22 Cryo EM structure of SARS-CoV-2 spike in complex with TAU-2212 mAbs in conformation 4 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Ma, B., Li, R. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7wcd A B 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/10/22 Cryo EM structure of SARS-CoV-2 spike in complex with TAU-2212 mAbs in conformation 4 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiang, Y., Ma, B., Li, R. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7xkd N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/10/22 Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex Camelus bactrianus; Homo sapiens camelus bactrianus homo sapiens | homo sapiens | homo sapiens Guo, S.C., Xiao, P., Lin, H., Sun, J.P., Yu, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xke N NA 0 A | B protein | protein NA | NA mini-gs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/10/22 Cryo-EM structure of DHEA-ADGRG2-FL-Gs complex Camelus bactrianus; Homo sapiens; Mus musculus camelus bactrianus homo sapiens | homo sapiens Guo, S.C., Xiao, P., Lin, H., Sun, J.P., Yu, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xkf N NA 0 A | G | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/10/22 Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex at lower state Camelus bactrianus; Homo sapiens; Mus musculus camelus bactrianus homo sapiens | homo sapiens | homo sapiens Guo, S.C., Xiao, P., Lin, H., Sun, J.P., Yu, X. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7y0g B A 0 B Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 08/10/22 Crystal structure of anti-mPEG h15-2b Fab Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Lin, E.C., Su, Y.C. 2.08 X-RAY DIFFRACTION 0.245 0.211 False True IGHV3 IGKV1 Kappa None None None None None 7y0g E D 0 E Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 08/10/22 Crystal structure of anti-mPEG h15-2b Fab Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Lin, E.C., Su, Y.C. 2.08 X-RAY DIFFRACTION 0.245 0.211 False True IGHV3 IGKV1 Kappa None None None None None 7y0g H G 0 H Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 08/10/22 Crystal structure of anti-mPEG h15-2b Fab Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Lin, E.C., Su, Y.C. 2.08 X-RAY DIFFRACTION 0.245 0.211 False True IGHV3 IGKV1 Kappa None None None None None 7y0g K J 0 K Hapten P15 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL IMMUNE SYSTEM 08/10/22 Crystal structure of anti-mPEG h15-2b Fab Homo sapiens homo sapiens homo sapiens homo sapiens Chang, C.Y., Nguyen, T.M.T., Lin, E.C., Su, Y.C. 2.08 X-RAY DIFFRACTION 0.245 0.211 False True IGHV3 IGKV1 Kappa None None None None None 8cw9 J B 0 E protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 08/10/22 Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8cw9 C D 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 08/10/22 Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8cw9 G M 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 08/10/22 Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 8cw9 H L 0 F protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 08/10/22 Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8cw9 I K 0 E protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 08/10/22 Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 8cw9 N O 0 F protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 08/10/22 Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs Homo sapiens; Human metapneumovirus homo sapiens homo sapiens human metapneumovirus Hsieh, C.-L., McLellan, J.S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7t9n H L 0 R protein NA thyrotropin receptor MEMBRANE PROTEIN 08/03/22 M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure) Homo sapiens homo sapiens homo sapiens homo sapiens Faust, B., Cheng, Y., Manglik, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 7t9n N NA 0 X | Y protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/03/22 M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure) Homo sapiens homo sapiens homo sapiens | homo sapiens Faust, B., Cheng, Y., Manglik, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7fh0 B NA 0 A protein NA spike protein s1,spike protein s1 ANTIVIRAL PROTEIN 08/03/22 Crystallographic structure of two neutralizing nanobodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Zheng, P., Jin, J. 3.2 X-RAY DIFFRACTION 0.263 0.208 False True IGHV1 NA NA None None None None None 7fh0 C NA 0 A protein NA spike protein s1,spike protein s1 ANTIVIRAL PROTEIN 08/03/22 Crystallographic structure of two neutralizing nanobodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Zheng, P., Jin, J. 3.2 X-RAY DIFFRACTION 0.263 0.208 False True IGHV1 NA NA None None None None None 7qti G H 0 K protein NA spike glycoprotein,envelope glycoprotein VIRAL PROTEIN 08/03/22 SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ni, D., Lau, K., Turelli, P., Fenwick, C., Perez, L., Pojer, F., Stahlberg, H., Pantaleo, G., Trono, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7qti B C 0 A protein NA spike glycoprotein,envelope glycoprotein VIRAL PROTEIN 08/03/22 SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ni, D., Lau, K., Turelli, P., Fenwick, C., Perez, L., Pojer, F., Stahlberg, H., Pantaleo, G., Trono, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7qti F E 0 A protein NA spike glycoprotein,envelope glycoprotein VIRAL PROTEIN 08/03/22 SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ni, D., Lau, K., Turelli, P., Fenwick, C., Perez, L., Pojer, F., Stahlberg, H., Pantaleo, G., Trono, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7qti I J 0 D protein NA spike glycoprotein,envelope glycoprotein VIRAL PROTEIN 08/03/22 SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ni, D., Lau, K., Turelli, P., Fenwick, C., Perez, L., Pojer, F., Stahlberg, H., Pantaleo, G., Trono, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7qtj B C 0 A protein NA surface glycoprotein VIRAL PROTEIN 08/03/22 SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD up - 1-P2G3 and 1-P5C3 Fabs (Local) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ni, D., Lau, K., Turelli, P., Fenwick, C., Perez, L., Pojer, F., Stahlberg, H., Pantaleo, G., Trono, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7qtj F E 0 A protein NA surface glycoprotein VIRAL PROTEIN 08/03/22 SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD up - 1-P2G3 and 1-P5C3 Fabs (Local) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ni, D., Lau, K., Turelli, P., Fenwick, C., Perez, L., Pojer, F., Stahlberg, H., Pantaleo, G., Trono, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7qtk B C 0 D protein NA surface glycoprotein VIRAL PROTEIN 08/03/22 SARS-CoV-2 S Omicron Spike B.1.1.529 - RBD down - 1-P2G3 Fab (Local) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ni, D., Lau, K., Turelli, P., Fenwick, C., Perez, L., Pojer, F., Stahlberg, H., Pantaleo, G., Trono, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7t7b H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/03/22 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing antibody ADI-62113 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.59 X-RAY DIFFRACTION 0.267 0.221 False True IGHV1 IGKV1 Kappa None None None None None 7t9i N NA 0 X | Y protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/03/22 Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Faust, B., Cheng, Y., Manglik, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7tcq H L 0 C peptide NA pegylated spike s2 peptide VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 Crystal structure of SARS-CoV-2 neutralizing antibody WS6 in complex with spike S2 peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 2.02 X-RAY DIFFRACTION 0.213 0.172 False True IGHV1 IGKV4 Kappa None None None None None 7tcq A B 0 D peptide NA pegylated spike s2 peptide VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 Crystal structure of SARS-CoV-2 neutralizing antibody WS6 in complex with spike S2 peptide Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 2.02 X-RAY DIFFRACTION 0.213 0.172 False True IGHV1 IGKV4 Kappa None None None None None 7u09 H L 0 A peptide NA sars-cov-2 s fusion peptide VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 Crystal Structure of C13B8 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D. 2.1 X-RAY DIFFRACTION 0.239 0.190 False True IGHV4 IGLV3 Lambda None None None None None 7u0a H L 0 A peptide NA sars-cov-2 s fusion peptide VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 Crystal Structure of C77G12 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D. 1.7 X-RAY DIFFRACTION 0.187 0.154 False True IGHV3 IGKV1 Kappa None None None None None 7u0e A B 0 D peptide NA sars-cov-2 s fusion peptide VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 Crystal Structure of C13C9 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D. 2.1 X-RAY DIFFRACTION 0.203 0.179 False True IGHV1 IGLV3 Lambda None None None None None 7u0e H L 0 C peptide NA sars-cov-2 s fusion peptide VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 Crystal Structure of C13C9 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D. 2.1 X-RAY DIFFRACTION 0.203 0.179 False True IGHV1 IGLV3 Lambda None None None None None 7utz N NA 0 Y | Z | X protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 08/03/22 Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) Homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Faust, B., Cheng, Y., Manglik, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7vgr D C 0 A protein NA membrane protein VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 SARS-CoV-2 M protein dimer (long form) in complex with YN7756_1 Fab Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zhang, Z., Ohto, U., Shimizu, T. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7vgr F E 0 B protein NA membrane protein VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 SARS-CoV-2 M protein dimer (long form) in complex with YN7756_1 Fab Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zhang, Z., Ohto, U., Shimizu, T. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7vgs D C 0 A protein NA membrane protein VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 SARS-CoV-2 M protein dimer (short form) in complex with YN7717_9 Fab Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zhang, Z., Ohto, U., Shimizu, T. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7vgs F E 0 B protein NA membrane protein VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 SARS-CoV-2 M protein dimer (short form) in complex with YN7717_9 Fab Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Zhang, Z., Ohto, U., Shimizu, T. 0 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7vke B NA 0 A protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 HYDROLASE 08/03/22 Crystal structure of human CD38 ECD in complex with UniDab(TM) F11A Homo sapiens homo sapiens homo sapiens Schooten, W.V., Schellenberger, U., Ugamraj, H.S., Manicka, S., Bijpuria, S., Gondu, R.K. 1.9 X-RAY DIFFRACTION 0.231 0.193 False True IGHV3 NA NA None None None None None 7vvj N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/03/22 PTHrP-bound human PTH1R in complex with Gs Bos taurus; Homo sapiens; Rattus norvegicus; unidentified; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus Kobayashi, K., Kusakizako, T., Miyauchi, H., Tomita, A., Kobayashi, K., Shihoya, W., Yamashita, K., Nishizawa, T., Kato, H.E., Nureki, O. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7vvk N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/03/22 PTH-bound human PTH1R in complex with Gs (class1) Bos taurus; Homo sapiens; Rattus norvegicus; unidentified; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus Kobayashi, K., Kusakizako, T., Miyauchi, H., Tomita, A., Kobayashi, K., Shihoya, W., Yamashita, K., Nishizawa, T., Kato, H.E., Nureki, O. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7vvl N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/03/22 PTH-bound human PTH1R in complex with Gs (class2) Bos taurus; Homo sapiens; Rattus norvegicus; unidentified; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus Kobayashi, K., Kusakizako, T., Miyauchi, H., Tomita, A., Kobayashi, K., Shihoya, W., Yamashita, K., Nishizawa, T., Kato, H.E., Nureki, O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7vvm N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/03/22 PTH-bound human PTH1R in complex with Gs (class3) Bos taurus; Homo sapiens; Rattus norvegicus; unidentified; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus Kobayashi, K., Kusakizako, T., Miyauchi, H., Tomita, A., Kobayashi, K., Shihoya, W., Yamashita, K., Nishizawa, T., Kato, H.E., Nureki, O. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7vvn N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/03/22 PTH-bound human PTH1R in complex with Gs (class4) Bos taurus; Homo sapiens; Rattus norvegicus; unidentified; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus Kobayashi, K., Kusakizako, T., Miyauchi, H., Tomita, A., Kobayashi, K., Shihoya, W., Yamashita, K., Nishizawa, T., Kato, H.E., Nureki, O. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7vvo N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/03/22 PTH-bound human PTH1R in complex with Gs (class5) Bos taurus; Homo sapiens; Rattus norvegicus; unidentified; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus Kobayashi, K., Kusakizako, T., Miyauchi, H., Tomita, A., Kobayashi, K., Shihoya, W., Yamashita, K., Nishizawa, T., Kato, H.E., Nureki, O. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xms S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/03/22 CryoEM structure of somatostatin receptor 4 (SSTR4) in complex with Gi1 and its endogeneous ligand SST-14 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Wenli, Z., Shuo, H., Na, Q., Wenbo, Z., Mengjie, L., Dehua, Y., Ming-Wei, W., Wu, B., Zhao, Q. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xmt S s 0 A | C | B protein | peptide | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/03/22 CryoEM structure of somatostatin receptor 4 (SSTR4) with Gi1 and J-2156 Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Wenli, Z., Shuo, H., Na, Q., Wenbo, Z., Mengjie, L., Dehua, Y., Ming-Wei, W., Wu, B., Zhao, Q. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 8df5 A B 0 R protein NA spike protein s1 VIRAL PROTEIN/Hydrolase/Immune System 08/03/22 SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.7 X-RAY DIFFRACTION 0.217 0.177 False True IGHV1 IGKV3 Kappa None None None None None 8df5 C D 0 S protein NA spike protein s1 VIRAL PROTEIN/Hydrolase/Immune System 08/03/22 SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.7 X-RAY DIFFRACTION 0.217 0.177 False True IGHV1 IGKV3 Kappa None None None None None 8df5 H L 0 R protein NA spike protein s1 VIRAL PROTEIN/Hydrolase/Immune System 08/03/22 SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.7 X-RAY DIFFRACTION 0.217 0.177 False True IGHV3 IGKV1 Kappa None None None None None 8df5 M N 0 S protein NA spike protein s1 VIRAL PROTEIN/Hydrolase/Immune System 08/03/22 SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.7 X-RAY DIFFRACTION 0.217 0.177 False True IGHV3 IGKV1 Kappa None None None None None 8djk H L 0 B | A protein | protein NA | NA ubia prenyltransferase domain-containing protein 1 | 3-hydroxy-3-methylglutaryl-coenzyme a reductase Oxidoreductase/Immune System 08/03/22 HMGCR-UBIAD1 Complex State 2 Cricetulus griseus; Escherichia coli; Mus musculus mus musculus mus musculus cricetulus griseus | cricetulus griseus Chen, H., Qi, X., Li, X. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 8djm H L 0 B | A protein | protein NA | NA ubia prenyltransferase domain-containing protein 1 | 3-hydroxy-3-methylglutaryl-coenzyme a reductase Oxidoreductase/Immune System 08/03/22 HMGCR-UBIAD1 Complex State 1 Cricetulus griseus; Escherichia coli; Mus musculus mus musculus mus musculus cricetulus griseus | cricetulus griseus Chen, H., Qi, X., Li, X. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 8dt3 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/03/22 Cryo-EM structure of spike binding to Fab of neutralizing antibody (locally refined) Mus musculus; Severe acute respiratory syndrome coronavirus 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sun, P.C., Fang, Y., Bai, X.C., Chen, Z.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 7wjy B C 0 A | G protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron spike trimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wjy E F 0 D protein NA spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron spike trimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 8dfl E NA 0 A protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 07/13/22 Structure of human Kv1.3 with A0194009G09 nanobodies (alternate conformation) Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dfl F NA 0 B protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 07/13/22 Structure of human Kv1.3 with A0194009G09 nanobodies (alternate conformation) Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dfl G NA 0 C protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 07/13/22 Structure of human Kv1.3 with A0194009G09 nanobodies (alternate conformation) Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dfl H NA 0 D protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 07/13/22 Structure of human Kv1.3 with A0194009G09 nanobodies (alternate conformation) Aequorea victoria; Homo sapiens; Lama glama lama glama homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7re7 I J 0 NA NA NA NA IMMUNE SYSTEM 07/27/22 TCR mimic antibody (Fab fragment) in complex with AFP/HLA-A*02 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Dasgupta, M., Baker, B.M. 2.547 X-RAY DIFFRACTION 0.220 0.180 False True IGHV5 IGLV2 Lambda None None None None None 7re7 H L 0 A | C protein | peptide NA | NA mhc class i antigen | phe-met-asn-lys-phe-ile-tyr-glu-ile IMMUNE SYSTEM 07/27/22 TCR mimic antibody (Fab fragment) in complex with AFP/HLA-A*02 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Dasgupta, M., Baker, B.M. 2.547 X-RAY DIFFRACTION 0.220 0.180 False True IGHV5 IGLV2 Lambda None None None None None 7re9 H L 0 NA NA NA NA IMMUNE SYSTEM 07/27/22 TCR mimic antibody (Fab fragment) Homo sapiens homo sapiens homo sapiens Dasgupta, M., Baker, B.M. 2.77 X-RAY DIFFRACTION 0.267 0.223 False True IGHV5 IGLV2 Lambda None None None None None 7re9 A B 0 NA NA NA NA IMMUNE SYSTEM 07/27/22 TCR mimic antibody (Fab fragment) Homo sapiens homo sapiens homo sapiens Dasgupta, M., Baker, B.M. 2.77 X-RAY DIFFRACTION 0.267 0.223 False True IGHV5 IGLV2 Lambda None None None None None 7sk7 D C 0 B | A protein | protein NA | NA stromal cell-derived factor 1 | atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, and an extracellular Fab Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens | homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk7 K NA 0 NA NA NA NA SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, and an extracellular Fab Homo sapiens; Lama glama lama glama Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7xt8 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/27/22 Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Huang, S., Xu, P., Shen, D.D., Simon, I.A., Mao, C., Tan, Y., Zhang, H., Harpsoe, K., Li, H., Zhang, Y., You, C., Yu, X., Jiang, Y., Zhang, Y., Gloriam, D.E., Xu, H.E. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xta E e 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 07/27/22 Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Huang, S., Xu, P., Shen, D.D., Simon, I.A., Mao, C., Tan, Y., Zhang, H., Harpsoe, K., Li, H., Zhang, Y., You, C., Yu, X., Jiang, Y., Zhang, Y., Gloriam, D.E., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xtb N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/27/22 Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Huang, S., Xu, P., Shen, D.D., Simon, I.A., Mao, C., Tan, Y., Zhang, H., Harpsoe, K., Li, H., Zhang, Y., You, C., Yu, X., Jiang, Y., Zhang, Y., Gloriam, D.E., Xu, H.E. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xtc N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 07/27/22 Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens | homo sapiens Huang, S., Xu, P., Shen, D.D., Simon, I.A., Mao, C., Tan, Y., Zhang, H., Harpsoe, K., Li, H., Zhang, Y., You, C., Yu, X., Jiang, Y., Zhang, Y., Gloriam, D.E., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ums 4 5 0 1 | U protein | protein NA | NA outer capsid protein vp5* | outer capsid protein vp8* VIRUS 01/08/09 Structure of the VP5*/VP8* assembly from the human rotavirus strain CDC-9 in complex with antibody 41 - Upright conformation Homo sapiens; Rotavirus homo sapiens homo sapiens rotavirus | rotavirus Jenni, S., Zongli, L., Wang, Y., Bessey, T., Salgado, E.N., Schmidt, A.G., Greenberg, H.B., Jiang, B., Harrison, S.C. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7ums 6 7 0 2 | T protein | protein NA | NA outer capsid protein vp5* | outer capsid protein vp8* VIRUS 01/08/09 Structure of the VP5*/VP8* assembly from the human rotavirus strain CDC-9 in complex with antibody 41 - Upright conformation Homo sapiens; Rotavirus homo sapiens homo sapiens rotavirus | rotavirus Jenni, S., Zongli, L., Wang, Y., Bessey, T., Salgado, E.N., Schmidt, A.G., Greenberg, H.B., Jiang, B., Harrison, S.C. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 8dao C D 0 I peptide NA spike protein s2 fusion peptide IMMUNE SYSTEM 07/27/22 Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV44-79 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lin, T.H., Lee, C.C.D., Yuan, M., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.284 0.231 False True IGHV3 IGKV1 Kappa None None None None None 8dao A B 0 J peptide NA spike protein s2 fusion peptide IMMUNE SYSTEM 07/27/22 Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV44-79 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lin, T.H., Lee, C.C.D., Yuan, M., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.284 0.231 False True IGHV3 IGKV1 Kappa None None None None None 7t0w H L 0 D | C protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-2 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Complex of GABA-A synaptic receptor with autoimmune antibody Fab115 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Noviello, C.M., Hibbs, R.E., Kreye, J., Teng, J., Pruss, H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7t0z H L 0 D | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit gamma-2 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/08/09 Complex of GABA-A synaptic receptor with autoimmune antibody Fab175 Homo sapiens homo sapiens homo sapiens homo sapiens | homo sapiens Noviello, C.M., Hibbs, R.E., Kreye, J., Teng, J., Pruss, H. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7ozt A NA 0 B protein NA unknown CELL CYCLE 01/08/09 Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a Homo sapiens; Lama glama Pastok, M.W., Burbidge, O., Itzhaki, L., Endicott, J.A., Noble, M.E.M. 1.74 X-RAY DIFFRACTION 0.209 0.180 False False IGHV1 NA NA None None None None None 7fgj H L 0 C peptide NA vqilnk IMMUNE SYSTEM 07/27/22 The cross-reaction complex structure with VQILNK peptide and the tau antibody's Fab domain. Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tsuchida, T., Tsuchiya, T., Miyamoto, K., In, Y., Minoura, K., Taniguchi, T., Ishida, T., Tomoo, K. 1.89 X-RAY DIFFRACTION 0.262 0.196 False False IGHV1 IGLV3 Lambda None None None None None 7fgk H L 0 NA NA NA NA IMMUNE SYSTEM 07/27/22 The Fab antibody single structure against tau protein. Mus musculus mus musculus mus musculus Tsuchida, T., Susa, K., Kibiki, T., Tsuchiya, T., Miyamoto, K., In, Y., Minoura, K., Taniguchi, T., Ishida, T., Tomoo, K. 2.3 X-RAY DIFFRACTION 0.299 0.199 False False IGHV1 IGLV3 Lambda None None None None None 7fgl H L 0 C peptide NA vqivyk IMMUNE SYSTEM 07/27/22 The complex structure of PHF core domain peptide of tau, VQIVYK, and antibody's Fab domain. Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tsuchida, T., Tsuchiya, T., Miyamoto, K., In, Y., Minoura, K., Taniguchi, T., Ishida, T., Tomoo, K. 2.1 X-RAY DIFFRACTION 0.270 0.200 False False IGHV1 IGLV3 Lambda None None None None None 7fgr H L 0 C peptide NA vqifnk IMMUNE SYSTEM 07/27/22 The cross-reaction complex structure with VQIFNK peptide and the tau antibody's Fab domain. Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tsuchida, T., Tsuchiya, T., Miyamoto, K., In, Y., Minoura, K., Taniguchi, T., Ishida, T., Tomoo, K. 2.2 X-RAY DIFFRACTION 0.272 0.200 False False IGHV1 IGLV3 Lambda None None None None None 7noz R NA 0 D | C protein | protein NA | NA properdin | properdin IMMUNE SYSTEM 07/27/22 Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP Homo sapiens; Lama glama lama glama homo sapiens | homo sapiens Lorenzen, J., Pedersen, D.V., Andersen, G.R. 3.9 X-RAY DIFFRACTION 0.265 0.249 False True IGHV1 NA NA None None None None None 7qe5 B NA 0 A protein NA sialic acid trap transporter permease protein siat TRANSPORT PROTEIN 07/27/22 Structure of the membrane domains of the sialic acid TRAP transporter HiSiaQM from Haemophilus influenzae Haemophilus influenzae; Vicugna pacos vicugna pacos haemophilus influenzae Peter, M.F., Hagelueken, G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7sk3 D C 0 B protein NA stromal cell-derived factor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk3 F E 0 A protein NA atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk4 D C 0 B protein NA stromal cell-derived factor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ, an intracellular Fab, and an extracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk4 F E 0 A protein NA atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ, an intracellular Fab, and an extracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk5 F E 0 A protein NA atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab Homo sapiens; Lama glama homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk5 K NA 0 NA NA NA NA SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab Homo sapiens; Lama glama lama glama Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7sk6 F E 0 A protein NA atypical chemokine receptor 3 SIGNALING PROTEIN 07/27/22 Cryo-EM structure of human ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ and an intracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk8 D C 0 B protein NA stromal cell-derived factor 1 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk8 F E 0 A protein NA atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sk9 F E 0 A protein NA atypical chemokine receptor 3 SIGNALING PROTEIN/IMMUNE SYSTEM 07/27/22 Cryo-EM structure of human ACKR3 in complex with a small molecule partial agonist CCX662, and an intracellular Fab Homo sapiens homo sapiens homo sapiens homo sapiens Yen, Y.C., Schafer, C.T., Gustavsson, M., Handel, T.M., Tesmer, J.J.G. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7w0l S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/27/22 Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule Escherichia coli; Homo sapiens; Trichoplusia ni homo sapiens homo sapiens | homo sapiens Yue, Y., Liu, L.E., Wu, L.J., Xu, F., Hanson, M. 3.57 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7w0m S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/27/22 Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Xu, F., Yue, Y., Liu, L.E., Wu, L.J., Hanson, M. 3.71 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7w0n S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/27/22 Cryo-EM structure of a dimeric GPCR-Gi complex with peptide Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Xu, F., Yue, Y., Wu, L.J., Liu, L.E., Hanson, M. 4.21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7w0o S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/27/22 Cryo-EM structure of a monomeric GPCR-Gi complex with peptide Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Xu, F., Yue, Y., Liu, L.E., Wu, L.J., Hanson, M. 3.78 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7w0p S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/27/22 Cryo-EM structure of a GPCR-Gi complex with peptide Escherichia coli; Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Xu, F., Yue, Y., Liu, L.E., Wu, L.J., Hanson, M. 3.16 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xtp C NA 0 A protein NA eukaryotic translation initiation factor 4e RNA BINDING PROTEIN 07/27/22 eIF4E in Complex with a Disulphide-Free Autonomous VH Domain Homo sapiens homo sapiens homo sapiens Brown, C.J., Frosi, Y., Jiang, S., Lin, Y.C. 1.828 X-RAY DIFFRACTION 0.259 0.226 False True IGHV3 NA NA None None None None None 7xtp D NA 0 B protein NA eukaryotic translation initiation factor 4e RNA BINDING PROTEIN 07/27/22 eIF4E in Complex with a Disulphide-Free Autonomous VH Domain Homo sapiens homo sapiens homo sapiens Brown, C.J., Frosi, Y., Jiang, S., Lin, Y.C. 1.828 X-RAY DIFFRACTION 0.259 0.226 False True IGHV3 NA NA None None None None None 8d36 H L 0 F peptide NA spike protein s2 fusion peptide IMMUNE SYSTEM 07/27/22 Crystal structure of SARS-CoV-2 fusion peptide in complex with neutralizing antibody COV44-62 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Lee, C.C.D., Wilson, I.A. 1.45 X-RAY DIFFRACTION 0.219 0.197 False True IGHV1 IGLV2 Lambda None None None None None 8d6z A B 0 H peptide NA spike protein s2 fusion peptide IMMUNE SYSTEM 07/27/22 Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV91-27 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Yuan, M., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.279 0.235 False True IGHV3 IGKV3 Kappa None None None None None 8d6z C D 0 K peptide NA spike protein s2 fusion peptide IMMUNE SYSTEM 07/27/22 Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV91-27 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Yuan, M., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.279 0.235 False True IGHV3 IGKV3 Kappa None None None None None 8d6z E F 0 J peptide NA spike protein s2 fusion peptide IMMUNE SYSTEM 07/27/22 Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV91-27 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Yuan, M., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.279 0.235 False True IGHV3 IGKV3 Kappa None None None None None 8d6z G I 0 L peptide NA spike protein s2 fusion peptide IMMUNE SYSTEM 07/27/22 Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV91-27 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lee, C.C.D., Lin, T.H., Yuan, M., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.279 0.235 False True IGHV3 IGKV3 Kappa None None None None None 8dcr N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/27/22 Cryo-EM structure of dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein Bos taurus; Lama glama; Meleagris gallopavo lama glama bos taurus | bos taurus Su, M., Paknejad, N., Hite, R.K., Huang, X.Y. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8dcs N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/27/22 Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein Bos taurus; Lama glama; Meleagris gallopavo lama glama bos taurus | bos taurus Su, M., Paknejad, N., Hite, R.K., Huang, X.Y. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7skz H L 0 A peptide NA pro-ser-lys-arg-ser-phe-ile-glu-asp-leu-leu-phe-asn VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Crystal Structure of VN01H1 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.86 X-RAY DIFFRACTION 0.234 0.199 False True IGHV3 IGKV3 Kappa None None None None None 7sl5 A B 0 C peptide NA pro-ser-lys-arg-ser-phe-ile-glu-asp-leu-leu-phe-asn VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Crystal Structure of VP12E7 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 X-RAY DIFFRACTION 0.238 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7sl5 D E 0 F peptide NA pro-ser-lys-arg-ser-phe-ile-glu-asp-leu-leu-phe-asn VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Crystal Structure of VP12E7 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 X-RAY DIFFRACTION 0.238 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7sl5 G H 0 I peptide NA pro-ser-lys-arg-ser-phe-ile-glu-asp-leu-leu-phe-asn VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Crystal Structure of VP12E7 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 X-RAY DIFFRACTION 0.238 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7sl5 J K 0 L peptide NA pro-ser-lys-arg-ser-phe-ile-glu-asp-leu-leu-phe-asn VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Crystal Structure of VP12E7 Fab in complex with SARS-CoV-2 S fusion peptide mammal environmental sample; SYNTHETIC CONSTRUCT mammal environmental sample mammal environmental sample severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 X-RAY DIFFRACTION 0.238 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7u9g G D 0 B protein NA glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122 Homo sapiens; Rabies virus homo sapiens homo sapiens rabies virus Callaway, H.M., Zyla, D., Larrous, F., Dias de Melo, G., Hastie, K.M., Avalos, R.D., Agarwal, A., Bouhry, H., Corti, D., Saphire, E.O. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7u9g H E 0 C protein NA glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122 Homo sapiens; Rabies virus homo sapiens homo sapiens rabies virus Callaway, H.M., Zyla, D., Larrous, F., Dias de Melo, G., Hastie, K.M., Avalos, R.D., Agarwal, A., Bouhry, H., Corti, D., Saphire, E.O. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7u9g I F 0 A protein NA glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122 Homo sapiens; Rabies virus homo sapiens homo sapiens rabies virus Callaway, H.M., Zyla, D., Larrous, F., Dias de Melo, G., Hastie, K.M., Avalos, R.D., Agarwal, A., Bouhry, H., Corti, D., Saphire, E.O. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7um5 E e 0 B | C protein | protein NA | NA minigo protein | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/20/22 CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, S., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7um6 E e 0 B | C protein | protein NA | NA minigo protein | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/20/22 CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, S., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7um7 E e 0 B | C protein | protein NA | NA minigo protein | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/20/22 CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine Homo sapiens; Mus musculus mus musculus homo sapiens | homo sapiens Zhang, S., Fay, J.F., Roth, B.L. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ura H L 0 A protein NA isoform 2 of protein-serine o-palmitoleoyltransferaseporcupine TRANSFERASE/TRANSFERASE INHIBITOR 07/20/22 Human PORCN in complex with Palmitoleoyl-CoA Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Liu, Y., Qi, X., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7urc H L 0 A protein NA isoform 2 of protein-serine o-palmitoleoyltransferaseporcupine TRANSFERASE/TRANSFERASE INHIBITOR 07/20/22 Human PORCN in complex with LGK974 Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Liu, Y., Qi, X., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7urd H L 0 A protein NA isoform 2 of protein-serine o-palmitoleoyltransferaseporcupine TRANSFERASE/TRANSFERASE INHIBITOR 07/20/22 Human PORCN in complex with LGK974 and WNT3A peptide Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Liu, Y., Qi, X., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7ure H L 0 A protein NA isoform 2 of protein-serine o-palmitoleoyltransferaseporcupine TRANSFERASE/TRANSFERASE INHIBITOR 07/20/22 Human PORCN in complex with palmitoleoylated WNT3A peptide Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Liu, Y., Qi, X., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 7urf O P 0 A protein NA protein-cysteine n-palmitoyltransferase hhat TRANSFERASE/TRANSFERASE INHIBITOR 07/20/22 Human HHAT H379C in complex with SHH N-terminal peptide Homo sapiens; Mus musculus mus musculus mus musculus homo sapiens Liu, Y., Qi, X., Li, X. 0 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV1 Kappa None None None None None 7vpy A NA 0 NA NA NA NA IMMUNE SYSTEM 07/20/22 Crystal structure of the neutralizing nanobody P86 against SARS-CoV-2 Vicugna pacos vicugna pacos Maeda, R., Fujita, J., Konishi, Y., Kazuma, Y., Yamazaki, H., Anzai, I., Yamaguchi, K., Kasai, K., Nagata, K., Yamaoka, Y., Miyakawa, K., Ryo, A., Shirakawa, K., Makino, F., Matsuura, Y., Inoue, T., Imura, A., Namba, K., Takaori-Kondo, A. 1.6 X-RAY DIFFRACTION 0.213 0.177 False True IGHV1 NA NA None None None None None 7vpy B NA 0 NA NA NA NA IMMUNE SYSTEM 07/20/22 Crystal structure of the neutralizing nanobody P86 against SARS-CoV-2 Vicugna pacos vicugna pacos Maeda, R., Fujita, J., Konishi, Y., Kazuma, Y., Yamazaki, H., Anzai, I., Yamaguchi, K., Kasai, K., Nagata, K., Yamaoka, Y., Miyakawa, K., Ryo, A., Shirakawa, K., Makino, F., Matsuura, Y., Inoue, T., Imura, A., Namba, K., Takaori-Kondo, A. 1.6 X-RAY DIFFRACTION 0.213 0.177 False True IGHV1 NA NA None None None None None 7vq0 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Cryo-EM structure of the SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Maeda, R., Fujita, J., Konishi, Y., Kazuma, Y., Yamazaki, H., Anzai, I., Yamaguchi, K., Kasai, K., Nagata, K., Yamaoka, Y., Miyakawa, K., Ryo, A., Shirakawa, K., Makino, F., Matsuura, Y., Inoue, T., Imura, A., Namba, K., Takaori-Kondo, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7vq0 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Cryo-EM structure of the SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Maeda, R., Fujita, J., Konishi, Y., Kazuma, Y., Yamazaki, H., Anzai, I., Yamaguchi, K., Kasai, K., Nagata, K., Yamaoka, Y., Miyakawa, K., Ryo, A., Shirakawa, K., Makino, F., Matsuura, Y., Inoue, T., Imura, A., Namba, K., Takaori-Kondo, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7vq0 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/20/22 Cryo-EM structure of the SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Maeda, R., Fujita, J., Konishi, Y., Kazuma, Y., Yamazaki, H., Anzai, I., Yamaguchi, K., Kasai, K., Nagata, K., Yamaoka, Y., Miyakawa, K., Ryo, A., Shirakawa, K., Makino, F., Matsuura, Y., Inoue, T., Imura, A., Namba, K., Takaori-Kondo, A. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7wo4 D E 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 dimer trimer ) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo4 F G 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 dimer trimer ) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo4 H I 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 dimer trimer ) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo4 M N 0 K protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 dimer trimer ) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo4 O P 0 J protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 dimer trimer ) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo4 Q R 0 L protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 dimer trimer ) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo5 D E 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo5 F G 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo5 H I 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-15 (S-553-15 trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wo7 A B 0 C protein NA spike protein s1 VIRAL PROTEIN 07/20/22 Locally refined region of SARS-CoV-2 Spike in complex with IgG 553-15 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7woa D B 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-60 (1-up trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7woa F G 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-60 (1-up trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wob D B 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-60 (2-up trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wob F G 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-60 (2-up trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wob H I 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/20/22 SARS-CoV-2 Spike in complex with IgG 553-60 (2-up trimer) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7woc A B 0 C protein NA spike protein s1 VIRAL PROTEIN 07/20/22 S-mAb60 NRAb1 local-refined map"" into ""Locally refined region of SARS-CoV-2 Spike in complex with IgG 553-60 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wog A B 0 C protein NA spike protein s1 VIRAL PROTEIN 07/20/22 SARS-CoV-2 Omicron S monomer complexed with 553-49 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7wp0 H L 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 07/20/22 Cryo-EM structure of SARS-CoV-2 Delta S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7wp2 H L 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 07/20/22 Cryo-EM structure of SARS-CoV-2 C.1.2 S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7xou N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 NEUROPEPTIDE 07/20/22 Structural insights into human brain gut peptide cholecystokinin receptors Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xov N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 NEUROPEPTIDE 07/20/22 Structural insights into human brain gut peptide cholecystokinin receptors Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7xow E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 NEUROPEPTIDE 07/20/22 Structural insights into human brain gut peptide cholecystokinin receptors Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Ding, Y., Zhang, H., Liao, Y., Chen, L., Ji, S. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y12 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/20/22 Cryo-EM structure of MrgD-Gi complex with beta-alanine Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | mus musculus Suzuki, S., Iida, M., Kawamoto, A., Oshima, A. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7y15 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/20/22 Cryo-EM structure of apo-state MrgD-Gi complex Escherichia coli; Homo sapiens; Mus musculus; synthetic construct synthetic construct homo sapiens | mus musculus Suzuki, S., Iida, M., Kawamoto, A., Oshima, A. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7fbi H L 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 07/13/22 Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5 Epstein-Barr virus (strain GD1); Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus epstein-barr virus (strain gd1) Zheng, Q., Li, S., Zha, Z., Hong, J., Chen, Y., Zhang, X. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7fbi N M 0 A protein NA envelope glycoprotein b VIRAL PROTEIN 07/13/22 Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5 Epstein-Barr virus (strain GD1); Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus epstein-barr virus (strain gd1) Zheng, Q., Li, S., Zha, Z., Hong, J., Chen, Y., Zhang, X. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7rpt A B 0 NA NA NA NA ANTIVIRAL PROTEIN 07/13/22 Crystal Structure of Protective Human Antibody 3A6 Fab Against Ebola Virus Homo sapiens homo sapiens homo sapiens Salie, Z.L., Saphire, E.O., Davis, C.W., Ahmed, R. 2.5 X-RAY DIFFRACTION 0.254 0.198 False True IGHV3 IGKV2 Kappa None None None None None 7rpt C D 0 NA NA NA NA ANTIVIRAL PROTEIN 07/13/22 Crystal Structure of Protective Human Antibody 3A6 Fab Against Ebola Virus Homo sapiens homo sapiens homo sapiens Salie, Z.L., Saphire, E.O., Davis, C.W., Ahmed, R. 2.5 X-RAY DIFFRACTION 0.254 0.198 False True IGHV3 IGKV2 Kappa None None None None None 7rpt E F 0 NA NA NA NA ANTIVIRAL PROTEIN 07/13/22 Crystal Structure of Protective Human Antibody 3A6 Fab Against Ebola Virus Homo sapiens homo sapiens homo sapiens Salie, Z.L., Saphire, E.O., Davis, C.W., Ahmed, R. 2.5 X-RAY DIFFRACTION 0.254 0.198 False True IGHV3 IGKV2 Kappa None None None None None 7rpt G H 0 NA NA NA NA ANTIVIRAL PROTEIN 07/13/22 Crystal Structure of Protective Human Antibody 3A6 Fab Against Ebola Virus Homo sapiens homo sapiens homo sapiens Salie, Z.L., Saphire, E.O., Davis, C.W., Ahmed, R. 2.5 X-RAY DIFFRACTION 0.254 0.198 False True IGHV3 IGKV2 Kappa None None None None None 7rpu A B 0 P peptide NA gp2 epitope peptide ANTIVIRAL PROTEIN 07/13/22 Crystal Structure of Protective Human Antibody 3A6 Fab Against Ebola Virus with GP Stalk/MPER Epitope Peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens zaire ebolavirus (strain eckron-76) Salie, Z.L., Saphire, E.O., Davis, C.W., Ahmed, R. 1.27 X-RAY DIFFRACTION 0.160 0.141 False True IGHV3 IGKV2 Kappa None None None None None 7wj5 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 07/13/22 Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity Escherichia coli; Homo sapiens homo sapiens homo sapiens | homo sapiens Heo, Y.S., Yoon, E.J., Jeon, Y.E., Yun, J.-H., Ishimoto, N., Woo, H., Park, S.Y., Song, J., Lee, W.T. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7wjz A C 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron Spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wjz D N 0 I protein NA spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron Spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wjz E O 0 J protein NA spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron Spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wjz F P 0 K protein NA spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron Spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wjz G Q 0 L protein NA spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron Spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wjz H R 0 M protein NA spike glycoprotein VIRAL PROTEIN 07/13/22 Omicron Spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wk0 A B 0 C protein NA spike protein s1 VIRAL PROTEIN 07/13/22 Local refine of Omicron spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7wk0 D E 0 F protein NA spike protein s1 VIRAL PROTEIN 07/13/22 Local refine of Omicron spike bitrimer with 6m6 antibody Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7won H L 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 Cryo-EM structure of SARS-CoV-2 S2P trimer in complex with neutralizing antibody VacW-209 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7wp1 H L 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 07/13/22 Cryo-EM structure of SARS-CoV-2 Mu S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7wp5 H L 0 F protein NA spikeprotein s1 IMMUNE SYSTEM/VIRAL PROTEIN 07/13/22 Cryo-EM structure of SARS-CoV-2 Omicron S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Sun, H., Ju, B., Zhang, Z., Li, S., Xia, N. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7x6a H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 SARS-CoV-2 BA.2 variant spike protein in complex with Fab BD55-5840 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV3 Kappa None None None None None 7x6a G J 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 SARS-CoV-2 BA.2 variant spike protein in complex with Fab BD55-5840 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV3 Kappa None None None None None 7x6a I K 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/13/22 SARS-CoV-2 BA.2 variant spike protein in complex with Fab BD55-5840 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV3 Kappa None None None None None 7xbd E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/13/22 Cryo-EM structure of human galanin receptor 2 Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Ishimoto, N., Kita, S., Park, S.Y. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7xqv B NA 0 A protein NA rhoa PROTEIN BINDING 07/13/22 The complex of nanobody Rh57 binding to GTP-bound RhoA active form Camelus bactrianus; Rattus norvegicus camelus bactrianus rattus norvegicus Zhang, Y.R., Liu, R., Ding, Y. 2.76 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 NA NA None None None None None 7z6v X NA 0 A protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H., Vogirala, V.K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z6v Y NA 0 B protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H., Vogirala, V.K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z6v Z NA 0 C protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H., Vogirala, V.K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z7x F NA 0 C protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H6 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z7x D NA 0 A protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H6 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z7x E NA 0 B protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H6 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z85 F NA 0 C protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-B5 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z85 D NA 0 A protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-B5 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z85 E NA 0 B protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-B5 nanobody complex Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z86 X NA 0 A protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 1Up2Down conformation Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z86 Y NA 0 B protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 1Up2Down conformation Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z86 Z NA 0 C protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 1Up2Down conformation Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z9q D NA 0 C protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-A10 nanobody complex Lama glama; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 lama glama severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Weckener, M., Naismith, J.H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z9q E NA 0 A protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-A10 nanobody complex Lama glama; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 lama glama severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Weckener, M., Naismith, J.H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z9q F NA 0 B protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-A10 nanobody complex Lama glama; Severe acute respiratory syndrome coronavirus 2; Tequatrovirus T4 lama glama severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Weckener, M., Naismith, J.H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z9r Y NA 0 B protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 2Up1Down conformation Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z9r X NA 0 A protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 2Up1Down conformation Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7z9r Z NA 0 C protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 07/13/22 CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-H4 Q98R H100E nanobody complex in 2Up1Down conformation Escherichia virus T4; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2, escherichia virus t4 Weckener, M., Naismith, J.H. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7zms K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 07/13/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G4-043 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.7 X-RAY DIFFRACTION 0.275 0.235 False True IGHV1 NA NA None None None None None 7zyi H L 0 A protein NA sodium/bile acid cotransporter TRANSPORT PROTEIN 07/13/22 Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody Homo sapiens; Lama glama; Mus musculus mus musculus mus musculus homo sapiens Liu, H., Irobalieva, R.N., Nosol, K., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zyi K NA 0 NA NA NA NA TRANSPORT PROTEIN 07/13/22 Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody Homo sapiens; Lama glama; Mus musculus lama glama Liu, H., Irobalieva, R.N., Nosol, K., Locher, K.P. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7fah H L 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 Immune complex of head region of CA09 HA and neutralizing antibody 12H5 Influenza A virus (strain swl A/California/04/2009 H1N1); Mus musculus mus musculus mus musculus influenza a virus (strain swla/california/04/2009 h1n1) Li, T.T., Xue, W.H., Gu, Y., Li, S.W. 3.151 X-RAY DIFFRACTION 0.290 0.266 False False IGHV9 IGKV3 Kappa None None None None None 7fah C D 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 Immune complex of head region of CA09 HA and neutralizing antibody 12H5 Influenza A virus (strain swl A/California/04/2009 H1N1); Mus musculus mus musculus mus musculus influenza a virus (strain swla/california/04/2009 h1n1) Li, T.T., Xue, W.H., Gu, Y., Li, S.W. 3.151 X-RAY DIFFRACTION 0.290 0.266 False False IGHV9 IGKV3 Kappa None None None None None 7ra7 H L 0 NA NA NA NA IMMUNE SYSTEM 07/06/22 Crystal structure of rabbit anti-HIV Fab 11A Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Oyen, D., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.251 0.215 False True IGHV1 IGKV1 Kappa None None None None None 7ra7 A B 0 NA NA NA NA IMMUNE SYSTEM 07/06/22 Crystal structure of rabbit anti-HIV Fab 11A Oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Oyen, D., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.251 0.215 False True IGHV1 IGKV1 Kappa None None None None None 8cyd D NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-45 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyd E NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-45 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyd F NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-45 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyj A NA 0 R protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 RBD of SARS-CoV-2 Spike protein in complex with pan-sarbecovirus nanobodies 2-10, 2-67, 2-62 and 1-25 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyj B NA 0 R protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 RBD of SARS-CoV-2 Spike protein in complex with pan-sarbecovirus nanobodies 2-10, 2-67, 2-62 and 1-25 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyj C NA 0 R protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 RBD of SARS-CoV-2 Spike protein in complex with pan-sarbecovirus nanobodies 2-10, 2-67, 2-62 and 1-25 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8cyj D NA 0 R protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 RBD of SARS-CoV-2 Spike protein in complex with pan-sarbecovirus nanobodies 2-10, 2-67, 2-62 and 1-25 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8dcc H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 3 Bound to P2B-2F6 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dickey, T.D., Tolia, N.H. 2.6 X-RAY DIFFRACTION 0.272 0.221 False True IGHV4 IGLV2 Lambda None None None None None 7x1m A B 0 M protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 The complex structure of Omicron BA.1 RBD with BD604, S309,and S304 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huang, M., Xie, Y.F., Qi, J.X. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7x1m C D 0 M protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 The complex structure of Omicron BA.1 RBD with BD604, S309,and S304 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huang, M., Xie, Y.F., Qi, J.X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7x1m H L 0 M protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 The complex structure of Omicron BA.1 RBD with BD604, S309,and S304 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huang, M., Xie, Y.F., Qi, J.X. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xtq N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 07/06/22 Cryo-EM structure of the R399-bound GPBAR-Gs complex Homo sapiens; synthetic construct synthetic construct homo sapiens | homo sapiens | homo sapiens Ma, L., Yang, F., Wu, X., Mao, C., Sun, J., Yu, X., Zhang, Y., Zhang, P. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 8cy9 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-23 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cy9 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-23 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cy9 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-23 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cya D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-67 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cya E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-67 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cya F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-67 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7t92 H L 0 B protein NA peroxin-12 TRANSLOCASE 07/06/22 Structure of the peroxisomal retro-translocon formed by a heterotrimeric ubiquitin ligase complex synthetic construct; Thermothelomyces thermophilus ATCC 42464 synthetic construct synthetic construct thermothelomyces thermophilus atcc 42464 Peiqiang, F., Tom, R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7tz5 H N 0 C protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 Cryo-EM structure of antibody TJ5-5 bound to H3 COBRA TJ5 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Abbadi, N.S., Mousa, J.J. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7tz5 I L 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 Cryo-EM structure of antibody TJ5-5 bound to H3 COBRA TJ5 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Abbadi, N.S., Mousa, J.J. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7tz5 J M 0 B protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/06/22 Cryo-EM structure of antibody TJ5-5 bound to H3 COBRA TJ5 hemagglutinin Homo sapiens; Influenza A virus homo sapiens homo sapiens influenza a virus Abbadi, N.S., Mousa, J.J. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 8cyb D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-8 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyc D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-34 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyc E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-34 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cyc F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-34 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ran E e 0 B | C protein | protein NA | NA g protein subunit q (gi2-mini-gq chimera) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/06/22 5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) Homo sapiens homo sapiens homo sapiens | homo sapiens Barros-Alvarez, X., Kim, K., Panova, O., Roth, B.L., Skiniotis, G. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7szu H L 0 R nucleic-acid NA rna aptamer IMMUNE SYSTEM/RNA 07/06/22 Crystal structure of Pepper RNA aptamer in complex with HBC ligand and Fab BL3-6 Mus musculus; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Rees, H.C., Piccirilli, J.A. 2.24 X-RAY DIFFRACTION 0.263 0.219 False True IGHV3 IGKV1 Kappa None None None None None 8cy6 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-65 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cy6 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-65 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cy6 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-65 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cy7 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-34 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cy7 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-34 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cy7 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-34 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cwu B NA 0 A protein NA spike protein s1 IMMUNE SYSTEM 07/06/22 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing nanobody 1-21 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 1.71 X-RAY DIFFRACTION 0.203 0.185 False True IGHV1 NA NA None None None None None 8cwv H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 07/06/22 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing nanobody 2-31 and a human antibody CC12.1 Fab Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.51 X-RAY DIFFRACTION 0.264 0.238 False True IGHV3 IGKV1 Kappa None None None None None 8cwv B NA 0 A protein NA spike protein s1 IMMUNE SYSTEM 07/06/22 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing nanobody 2-31 and a human antibody CC12.1 Fab Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.51 X-RAY DIFFRACTION 0.264 0.238 False True IGHV1 NA NA None None None None None 8cxn D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-57 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cxn F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-57 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cxn E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-57 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cxq D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cxq E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8cxq F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/06/22 SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22 Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ssv H L 0 B | A | C | D protein | protein | protein | protein NA | NA | NA | NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion | potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion | potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion | potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 11/11/21 Structure of human Kv1.3 with Fab-ShK fusion Aequorea victoria; Homo sapiens; unidentified unidentified unidentified homo sapiens, aequorea victoria | homo sapiens, aequorea victoria | homo sapiens, aequorea victoria | homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P., Smider, V., Huang, R. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7ssz E NA 0 A protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 11/11/21 Structure of human Kv1.3 with A0194009G09 nanobodies Aequorea victoria; Homo sapiens; synthetic construct synthetic construct homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ssz F NA 0 B protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 11/11/21 Structure of human Kv1.3 with A0194009G09 nanobodies Aequorea victoria; Homo sapiens; synthetic construct synthetic construct homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ssz G NA 0 C protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 11/11/21 Structure of human Kv1.3 with A0194009G09 nanobodies Aequorea victoria; Homo sapiens; synthetic construct synthetic construct homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ssz H NA 0 D protein NA potassium voltage-gated channel subfamily a member 3,greenfluorescent protein fusion IMMUNE SYSTEM 11/11/21 Structure of human Kv1.3 with A0194009G09 nanobodies Aequorea victoria; Homo sapiens; synthetic construct synthetic construct homo sapiens, aequorea victoria Meyerson, J.R., Selvakumar, P. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6fe4 F NA 0 A protein shiga-like toxin 2 subunit b TOXIN 12/29/17 Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113 ENTEROBACTERIA PHAGE 933W; VICUGNA PACOS vicugna pacos enterobacteria phage 933w Bernedo, R., Muyldermans, S., Sterckx, Y.G.J. 3.0 X-RAY DIFFRACTION 0.207 0.169 False True IGHV3 9.6e-09 -10.938139080820335 SPR TBD 7jmo H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 08/02/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-04 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wu, N.C., Yuan, M., Liu, H., Zhu, X., Wilson, I.A. 2.359 X-RAY DIFFRACTION 0.238 0.195 False True IGHV3 IGKV3 Kappa None None None None None 6ch9 Q R 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated B41 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4.85 X-RAY DIFFRACTION 0.292 0.285 False True unknown IGLV3 Lambda None None None None None 4o51 B A 0 N peptide ides hinge peptide IMMUNE SYSTEM 12/19/13 Crystal structure of the QAA variant of anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide ORYCTOLAGUS CUNICULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens homo sapiens Malia, T.J., Luo, J., Teplyakov, A., Gilliland, G.L. 2.204 X-RAY DIFFRACTION 0.213 0.182 False True IGHV1 IGKV1 Kappa None None None None None 4nkd C D 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.303 X-RAY DIFFRACTION 0.231 0.195 False True IGHV1 IGKV1 Kappa None None None None None 7n0h Z NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 05/25/21 CryoEM structure of SARS-CoV-2 spike protein (S-6P, 2-up) in complex with sybodies (Sb45) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Huang, R., Margulies, D. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7orb E F 0 X protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the L452R mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-75 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.5 X-RAY DIFFRACTION 0.251 0.213 False True IGHV3 IGKV1 Kappa None None None None None 5w08 K L 0 C protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 05/30/17 A/Texas/50/2012(H3N2) Influenza hemagglutinin in complex with K03.12 Fab INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 2.6 X-RAY DIFFRACTION 0.262 0.240 False True IGHV1 IGLV2 Lambda 4e-08 -10.092595930642474 SPR TBD 5l21 B NA 0 A protein botulinum neurotoxin type a TOXIN 07/29/16 Crystal structure of BoNT/A receptor binding domain in complex with VHH C2 CLOSTRIDIUM BOTULINUM (STRAIN HALL / ATCC 3502 / NCTC 13319 / TYPE A); VICUGNA PACOS vicugna pacos clostridium botulinum (strain hall / atcc 3502/ nctc 13319 / type a) Yao, G., Jin, R. 1.68 X-RAY DIFFRACTION 0.205 0.193 False True unknown unknown unknown None None None None None 7q1u B NA 0 A protein NA protein-cysteine n-palmitoyltransferase hhat MEMBRANE PROTEIN 10/21/21 Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map) HOMO SAPIENS; ESCHERICHIA COLI K-12 escherichia coli k-12 homo sapiens Coupland, C., Carrique, L., Siebold, C. 2.7 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7lg6 J M 0 E | B protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/21 BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Torres, J.L., Wu, N.R., Ward, A.B. 3.28 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7a17 B NA 0 A protein NA isoform 2 of synaptojanin-1 HYDROLASE 08/12/20 Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Paesmans, J., Galicia, C., Martin, E., Versees, W. 2.73 X-RAY DIFFRACTION 0.257 0.196 False True IGHV1 NA NA None None None None None 5i1e H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-53/IGKV1-39 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.7 X-RAY DIFFRACTION 0.264 0.191 False True IGHV3 IGKV1 Kappa None None None None None 3eo0 D C 0 IMMUNE SYSTEM 09/26/08 Structure of the Transforming Growth Factor-Beta Neutralizing Antibody GC-1008 MUS MUSCULUS mus musculus mus musculus Gruetter, C., Gruetter, M.G. 1.75 X-RAY DIFFRACTION 0.201 0.182 False True IGHV1 IGKV8 Kappa None None None None None 6zdh H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/14/20 SARS-CoV-2 Spike glycoprotein in complex with a neutralizing antibody EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6x02 C NA 0 NA NA NA NA STRUCTURAL PROTEIN 05/15/20 Nup84-Nup133 (aa521-1157) from S. cerevisiae bound by VHH-SAN8 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos Nordeen, S.A., Schwartz, T.U. 6.38 X-RAY DIFFRACTION 0.324 0.314 False True IGHV1 NA NA None None None None None 7t6s E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/14/21 Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2 HOMO SAPIENS; RATTUS; BOS TAURUS rattus homo sapiens | rattus Zhuang, Y.W. 3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4ffv H L 0 A protein dipeptidyl peptidase 4 HYDROLASE/Immune System, INHIBITOR 06/01/12 Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Sudom, A., Walker, N.P., Min, X. 2.4 X-RAY DIFFRACTION 0.301 0.271 False False IGHV1 IGKV4 Kappa None None None None None 7cwn K I 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5cjs H L 0 D | C protein | protein NA | NA designed influenza hemagglutinin stem #4454, ha2 | designed influenza hemagglutinin stem #4454, ha1 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 Crystal structure of a monomeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct | synthetic construct Zhu, X., Wilson, I.A. 4.3 X-RAY DIFFRACTION 0.303 0.262 False True IGHV1 IGLV1 Lambda None None None None None 6mwx O P 0 N protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-69 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 8.2 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 2ny3 D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E267C, S334A, S375W) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.243 0.203 False True IGHV1 IGKV3 Kappa 8.15e-07 SPR 17301785 7lk9 A B 0 NA NA NA NA IMMUNE SYSTEM 02/01/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC + COVD21-C8 LC HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 3.4 X-RAY DIFFRACTION 0.312 0.276 False True IGHV3 IGKV3 Kappa None None None None None 7t0j H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.15 X-RAY DIFFRACTION 0.281 0.230 False True IGHV7 IGKV8 Kappa None None None None None 5jo4 A B 0 IMMUNE SYSTEM 05/01/16 Antibody Fab Fragment Complex HOMO SAPIENS homo sapiens homo sapiens Zhang, Z., Prachanronarong, K.P., Marasco, W.A., Schiffer, C.A.S. 2.53 X-RAY DIFFRACTION 0.248 0.197 False True IGHV1 IGKV3 Kappa None None None None None 6h7o D NA 0 B protein beta-1 adrenergic receptor ELECTRON TRANSPORT 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.8 X-RAY DIFFRACTION 0.274 0.240 False True IGHV1 1.4000000000000003e-10 -13.443086585131377 Unknown TBD 4yo0 C D 0 F peptide pa14 peptide IMMUNE SYSTEM 03/11/15 Crystal structure of monoclonal anti-human podoplanin antibody NZ-1 with bound PA peptide RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus homo sapiens Fujii, Y., Kitago, Y., Arimori, T., Takagi, J. 1.56 X-RAY DIFFRACTION 0.214 0.179 False True IGHV5 IGLV3 Lambda None None None None None 5ja9 B NA 0 D protein toxin higb-2 TOXIN 04/12/16 Crystal structure of the HigB2 toxin in complex with Nb6 LAMA GLAMA; VIBRIO CHOLERAE SEROTYPE O1 (STRAIN ATCC 39315 / EL TOR INABA N16961) lama glama vibrio cholerae serotype o1 (strain atcc 39315/ el tor inaba n16961) Hadzi, S., Loris, R. 1.849 X-RAY DIFFRACTION 0.241 0.195 False True IGHV1 None None None None None 1jvk NA A 0 IMMUNE SYSTEM 08/30/01 THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR HOMO SAPIENS homo sapiens Bourne, P.C., Ramsland, P.A., Shan, L., Fan, Z.-C., DeWitt, C.R., Shultz, B.B., Terzyan, S.S., Edmundson, A.B. 1.94 X-RAY DIFFRACTION 0.254 0.221 False False IGLV2 Lambda None None None None None 3qa3 B A 0 E protein integrin alpha-m IMMUNE SYSTEM/ cell adhesion 01/10/11 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 3.0 X-RAY DIFFRACTION 0.224 0.194 False False IGHV14 IGKV8 Kappa None None None None None 6x1t H L 0 M peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 2.34 X-RAY DIFFRACTION 0.269 0.244 False True IGHV1 IGKV1 Kappa None None None None None 1nca H L 0 N protein influenza a subtype n9 neuraminidase HYDROLASE(O-GLYCOSYL) 01/21/92 REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE-NC41 FAB COMPLEX INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Tulip, W.R., Varghese, J.N., Colman, P.M. 2.5 X-RAY DIFFRACTION unknown 0.191 False False IGHV9 IGKV6 Kappa 8.30e-09 -11.02 Other 25 9692956 4ypg H L 0 D protein interferon alpha-2 IMMUNE SYSTEM 03/12/15 Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oganesyan, V., Dall'Acqua, W.F. 3.0 X-RAY DIFFRACTION 0.272 0.206 False True IGHV1 IGKV3 Kappa 4.3999999999999997e-11 -14.128858472801308 SPR TBD 5toj E NA 0 B protein fusion glycoprotein f0, fibritin chimera VIRAL PROTEIN/IMMUNE SYSTEM 10/17/16 Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4 HUMAN RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama human respiratory syncytial virus Gilman, M.S.A., Kabeche, S.C., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.234 0.184 False True IGHV1 2.3e-08 -10.420467653019871 SPR TBD 1wtl NA B 0 IMMUNOGLOBULIN 06/08/94 COMPARISON OF CRYSTAL STRUCTURES OF TWO HOMOLOGOUS PROTEINS: STRUCTURAL ORIGIN OF ALTERED DOMAIN INTERACTIONS IN IMMUNOGLOBULIN LIGHT CHAIN DIMERS HOMO SAPIENS homo sapiens Huang, D.B., Chang, C.H., Schiffer, M. 1.9 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 7mta H L 5 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1maj NA A 8 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7mxl J K 0 C protein NA major pollen allergen bet v 1-a ALLERGEN 05/19/21 Complex of Bet v 1 with the Fab fragments of a three antibody cocktail HOMO SAPIENS; BETULA PENDULA homo sapiens homo sapiens betula pendula Romero-Hernandez, A., Franklin, M.C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7aqy D NA 0 A protein NA variant surface glycoprotein mitat 1.2 MEMBRANE PROTEIN 10/23/20 Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB11) LAMA GLAMA; TRYPANOSOMA BRUCEI BRUCEI lama glama trypanosoma brucei brucei Stebbins, C.E., Hempelmann, A., VanStraaten, M. 1.9 X-RAY DIFFRACTION 0.242 0.209 False True IGHV1 NA NA None None None None None 3t4y B A 0 B carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/26/11 S25-2- KDO monosaccharide complex MUS MUSCULUS mus musculus mus musculus mus musculus Nguyen, H.P., Seto, N.O., Mackenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.73 X-RAY DIFFRACTION 0.225 0.195 False True IGHV7 IGKV8 Kappa None None None None None 4u3x A NA 0 B protein lysozyme c IMMUNE SYSTEM 07/23/14 Structure of a human VH antibody domain binding to the cleft of hen egg lysozyme HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Rouet, R., Langley, D.B., Christ, D. 2.26 X-RAY DIFFRACTION 0.248 0.189 False True IGHV3 None None None None None 6hga H L 0 B protein interleukin-17 receptor c IMMUNE SYSTEM 08/23/18 Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rondeau, J.M., Goepfert, A. 2.6 X-RAY DIFFRACTION 0.232 0.205 False True IGHV8 IGKV1 Kappa None None None None None 6wj1 J K 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 04/11/20 Crystal structure of Fab 54-4H03 bound to H1 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Wilson, I.A. 3.503 X-RAY DIFFRACTION 0.232 0.179 False True IGHV6 IGKV3 Kappa None None None None None 1g9e A NA 16 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7s3n H L 0 A peptide NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/07/21 SARS-CoV-2 S stem helix peptide bound to Fab22 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Goldsmith, J.A., McLellan, J.S. 1.9 X-RAY DIFFRACTION 0.221 0.182 False True IGHV1 IGKV1 Kappa None None None None None 6q18 H L 0 A protein hemagglutinin IMMUNE SYSTEM 08/03/19 Human antibody H1244 in complex with the influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) McCarthy, K.R., Harrison, S.C. 2.55 X-RAY DIFFRACTION 0.243 0.206 False True IGHV4 IGLV3 Lambda None None None None None 6mph 3 4 0 E protein envelope glycoprotein gp41 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 2vxs J N 0 D protein interleukin-17a CYTOKINE 07/09/08 Structure of IL-17A in complex with a potent, fully human neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gerhardt, S., Hargreaves, D., Pauptit, R.A., Davies, R.A., Russell, C., Welsh, F., Tuske, S.J., Coales, S.J., Hamuro, Y., Needham, M.R.C., Langham, C., Barker, W., Bell, P., Aziz, A., Smith, M.J., Dawson, S., Abbott, W.M. 2.63 X-RAY DIFFRACTION 0.264 0.213 False True IGHV3 IGLV6 Lambda 2.10e-09 -11.83 SPR 19835883 7mno H L 0 A protein NA e3 sumo-protein ligase ranbp2 TRANSFERASE/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) I656V mutant in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 6.73 X-RAY DIFFRACTION 0.254 0.205 False True IGHV3 IGKV1 Kappa None None None None None 6oor H L 0 A protein NA antigen-presenting glycoprotein cd1d1 IMMUNE SYSTEM 04/23/19 Structure of 1B1 bound to mouse CD1d MUS MUSCULUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Ying, G., Zajonc, D.M. 2.45 X-RAY DIFFRACTION 0.244 0.208 False True IGHV5 IGKV9 Kappa None None None None None 6opa F I 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 04/01/20 Crystal structure of bovine Fab NC-Cow1 in complex with HIV-1 BG505 SOSIP.664, and human Fabs 35022 and PGT128 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Stanfield, R.L., Wilson, I.A. 4.084 X-RAY DIFFRACTION 0.343 0.332 False True unknown unknown unknown None None None None None 7tn0 M N 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/20/22 SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., McCallum, M., Veesler, D., Nix, J.C., Croll, T.I., Dillen, J.R., Czudnochowski, N. 2.85 X-RAY DIFFRACTION 0.268 0.230 False True IGHV3 IGKV1 Kappa None None None None None 2oqj E D 0 F peptide peptide 2g12.1 (acppshvldmrsgtclaaegk) Immune system 01/31/07 Crystal structure analysis of Fab 2G12 in complex with peptide 2G12.1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Menendez, A., Scott, J.K., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.275 0.234 False False IGHV3 IGKV1 Kappa 2.00e-04 -5.04 SPR 25 18198210 7bh8 G H 0 A | P protein | peptide NA | NA hla class i histocompatibility antigen, alpha chain e | vl9 leader peptide IMMUNE SYSTEM 01/10/21 3H4-Fab HLA-E-VL9 co-complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Walters, L.C., Rozbesky, D. 1.8 X-RAY DIFFRACTION 0.232 0.195 False True IGHV1 IGKV14 Kappa None None None None None 6ul6 C NA 0 A protein bont/a TOXIN/ANTITOXIN 10/07/19 Crystal Structure of BoNT/A-LCHn domain in complex with VNA ciA-D12/11/ciA-B5 and VHH ciA-H7 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.02 X-RAY DIFFRACTION 0.194 0.183 False True IGHV1 None None None None None 7mw6 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with three RBDs up in complex with the Fab fragment of human neutralizing antibody clone 2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4fqr a b 0 A protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 5y7z D NA 0 B protein cyclin-g-associated kinase TRANSFERASE/IMMUNE SYSTEM 08/18/17 Complex structure of cyclin G-associated kinase with gefitinib HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Ohbayashi, N., Murayama, K., Kato-Murayama, M., Shirouzu, M. 2.804 X-RAY DIFFRACTION 0.288 0.233 False True IGHV3 1.5400000000000002e-08 -10.658128680238939 Unknown TBD 3w13 C D 0 E protein insulin receptor domains l1-cr HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM 11/06/12 Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7 MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Smith, B.J., Brzozowski, A.M. 4.303 X-RAY DIFFRACTION 0.335 0.289 False True IGHV2 IGKV8 Kappa None None None None None 1dcl NA B 0 IMMUNOGLOBULIN 10/16/95 MCG, A LAMBDA V TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN), CRYSTALLIZED FROM AMMONIUM SULFATE HOMO SAPIENS homo sapiens Schiffer, M., Xu, Z.B. 2.3 X-RAY DIFFRACTION unknown 0.140 False False IGLV2 Lambda None None None None None 4tnw V Z 0 R protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False IGHV1 IGLV1 Lambda None None None None None 5bk5 H G 0 IMMUNE SYSTEM 09/12/17 Crystal structure of the anti-circumsporozoite protein 663 germline antibody HOMO SAPIENS homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 3.0 X-RAY DIFFRACTION 0.314 0.257 False True IGHV3 IGKV2 Kappa None None None None None 7rgp E e 0 A protein NA guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short MEMBRANE PROTEIN 07/15/21 cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT mus musculus homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7vnd D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/10/21 Structure of the SARS-CoV-2 spike glycoprotein in complex with a human single domain antibody n3113 (UUD-state, state 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Yang, Z., Wang, Y., Kong, Y., Jin, Y., Wu, Y., Ying, T. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4toy H L 0 IMMUNE SYSTEM 06/06/14 Structure of 35O22 Fab, a HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Pancera, M., Kwong, P.D. 1.551 X-RAY DIFFRACTION 0.182 0.167 False True unknown unknown unknown None None None None None 5da4 A NA 0 IMMUNE SYSTEM 08/19/15 Structure of a nanobody recognizing the fumarate transporter SLC26Dg LAMA GLAMA lama glama Dutzler, R., Geertsma, E.R., Chang, Y., Shaik, F.R. 2.4 X-RAY DIFFRACTION 0.242 0.233 False True IGHV1 None None None None None 4b50 A NA 0 NA NA NA NA IMMUNE SYSTEM 08/02/12 Crystal structure of the HIV-1 gp41 MPER-specific llama VHH 2H10 LAMA GLAMA lama glama Lutje Hulsik, D., Sabin, C., Macheboeuf, P., Weissenhorn, W. 1.3 X-RAY DIFFRACTION 0.17963 0.14502 False True IGHV1 NA NA None None None None None 5fuc E NA 0 C | B protein | protein NA | NA interleukin-6 receptor subunit alpha, interleukin-6receptor | interleukin-6 IMMUNE SYSTEM 01/25/16 Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies HOMO SAPIENS; CAMELUS DROMEDARIUS camelus dromedarius homo sapiens | homo sapiens Adams, R., Griffin, R., Doyle, C., Ettorre, A. 2.7 X-RAY DIFFRACTION 0.287 0.231 False True IGHV1 NA NA None None None None None 7li7 B C 0 A protein NA sodium-dependent serotonin transporter MEMBRANE PROTEIN 01/26/21 apo serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in occluded conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 6o2b O P 0 L | M peptide | protein NA | NA circumsporozoite protein | anti-kappa vhh domain IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein DND and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | lama glama Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.210 0.177 False True IGHV3 IGKV3 Kappa None None None None None 2ny0 D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, T257S, V275C, S334A, S375W, A433M) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.242 0.202 False True IGHV1 IGKV3 Kappa 2.32e-07 SPR 17301785 7rlw C D 0 R peptide NA pvcspvk210 peptide from circumsporozoite protein ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRAAGQPAGDRAAGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.54 X-RAY DIFFRACTION 0.253 0.201 False True IGHV1 IGKV1 Kappa None None None None None 6vi0 H L 0 G protein NA bg505 gp120 IMMUNE SYSTEM 01/10/20 Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.43 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 6idk H L 0 D protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 5.0 (Class I particle) DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 25 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7kxk I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/04/20 SARS-CoV-2 spike protein in complex with Fab 15033-7, 2-""up""-1-""down"" conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J. 5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1moe B b 0 IMMUNE SYSTEM 09/09/02 The three-dimensional structure of an engineered scFv T84.66 dimer or diabody in VL to VH linkage. MUS MUSCULUS mus musculus Carmichael, J.A., Power, B.E., Garrett, T.P.J., Yazaki, P.J., Shively, J.E., Raubischek, A.A., Wu, A.M., Hudson, P.J. 2.6 X-RAY DIFFRACTION 0.300 0.213 True True unknown unknown unknown None None None None None 2gfb L K 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 6myy G F 0 E protein 426c ds-sosip d3 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/18 Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 3 Fabs bound, sharpened map HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Borst, A.J., Weidle, C.E., Gray, M.D., Frenz, B., Snijder, J., Joyce, M.G., Georgiev, I.S., Stewart-Jones, G.B.E., Kwong, P.D., McGuire, A.T., DiMaio, F., Stamatatos, L., Pancera, M., Veesler, D. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7t4r P Q 0 K protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11 HOMO SAPIENS; HUMAN BETAHERPESVIRUS 5 homo sapiens homo sapiens human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6wf1 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin VIRAL PROTEIN/Immune System 04/03/20 Crystal Structure of Broadly Neutralizing Antibody 3I14 Bound to the Influenza A H10 Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Harshbarger, W.D., Lockbaum, G.J., Deming, D.T., Attatippaholkun, N., Schiffer, C.A., Marasco, W.A. 4.19 X-RAY DIFFRACTION 0.309 0.261 False True IGHV3 IGLV1 Lambda None None None None None 6xox E e 0 A protein NA alpha subunit of gs with n-terminus swapped with equivalentresidues in gi,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas MEMBRANE PROTEIN 07/07/20 cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA mus musculus homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2ai0 K O 0 IMMUNE SYSTEM 07/28/05 Anti-Cocaine Antibody 7.5.21, Crystal Form III MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Ringe, D., Petsko, G.A. 2.2 X-RAY DIFFRACTION 0.279 0.222 False False IGHV5 IGKV1 Kappa None None None None None 4imk B C 0 IMMUNE SYSTEM 01/03/13 Uncrossed Fab binding to human Angiopoietin 2 HOMO SAPIENS homo sapiens homo sapiens Fenn, S., Schiller, C., Griese, J.J., Hopfner, K.-P., Kettenberger, H. 2.202 X-RAY DIFFRACTION 0.226 0.199 False True IGHV1 IGLV3 Lambda None None None None None 6bdz H L 0 A protein disintegrin and metalloproteinase domain-containing protein10 MEMBRANE PROTEIN 10/24/17 ADAM10 Extracellular Domain Bound by the 11G2 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Seegar, T.C.M. 3.1 X-RAY DIFFRACTION 0.317 0.261 False True IGHV2 IGKV4 Kappa None None None None None 4hk3 J N 0 IMMUNE SYSTEM 10/14/12 I2 Fab (unbound) from CH65-CH67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 3.0 X-RAY DIFFRACTION 0.290 0.221 False True IGHV1 IGLV3 Lambda None None None None None 7dc8 B A 0 C protein NA interleukin-6 receptor subunit alpha IMMUNE SYSTEM 10/23/20 Crystal structure of Switch Ab Fab and hIL6R in complex with ATP HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kadono, S., Fukami, T.A., Kawauchi, H., Torizawa, T., Mimoto, F. 2.757 X-RAY DIFFRACTION 0.278 0.207 False True IGHV3 IGLV2 Lambda None None None None None 7rda H L 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM 07/09/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.138 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 1.92 X-RAY DIFFRACTION 0.232 0.198 False True IGHV1 IGKV4 Kappa None None None None None 4f9p D d 0 B protein butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 05/19/12 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 103.2 Single Chain Antibody HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Palakodeti, A., Sandstrom, A., Sundaresan, L., Harly, C., Nedellec, S., Olive, D., Scotet, E., Bonneville, M., Adams, E.J. 3.519 X-RAY DIFFRACTION 0.408 0.373 True True unknown unknown unknown 1.5000000000000002e-08 -10.67372125591851 SPR TBD 3t0v NA A 0 DYE-BINDING PROTEIN 07/20/11 Unliganded fluorogen activating protein M8VL HOMO SAPIENS homo sapiens Stanfield, R., Senutovitch, N., Bhattacharyya, S., Rule, G., Wilson, I.A., Armitage, B., Waggoner, A.S., Berget, P. 1.451 X-RAY DIFFRACTION 0.208 0.179 False True IGLV1 Lambda None None None None None 7wec I K 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein with three XGv347 Fabs binding to three closed state RBDs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7omn A NA 0 NA NA NA NA IMMUNE SYSTEM 05/24/21 Anti-EphA1 JD1-1 VH domain HOMO SAPIENS homo sapiens Ereno Orbea, J., Nilvebrant, J., Sidhu, S., Julien, J.P. 1.7 X-RAY DIFFRACTION 0.222 0.203 False True IGHV3 NA NA None None None None None 3duu B A 0 B carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/17/08 Crystal structure of SAG506-01, orthorhombic, twinned, crystal 2 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.217 0.194 False True IGHV7 IGKV8 Kappa None None None None None 4j8r B A 0 I peptide major prion protein IMMUNE SYSTEM 02/14/13 Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Swayampakula, M., Baral, P.K., Kav, N.N.V., Aguzzi, A., James, M.N.G. 2.303 X-RAY DIFFRACTION 0.257 0.247 False False IGHV1 IGKV6 Kappa 2e-08 -10.503274322962254 Unknown TBD 6mto H L 0 T protein vrc42 epitope t117-f scaffold IMMUNE SYSTEM 10/21/18 Crystal structure of VRC42.01 Fab in complex with T117-F MPER scaffold HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Druz, A., Law, W.H., Peng, D., Zhang, B., Doria-Rose, N.A., Kwong, P.D. 2.634 X-RAY DIFFRACTION 0.269 0.221 False True IGHV1 IGKV3 Kappa None None None None None 5ojm M NA 0 C protein human gabaa receptor chimera beta3-alpha5,gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 07/21/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 SYNTHETIC CONSTRUCT; HOMO SAPIENS; LAMA GLAMA lama glama synthetic construct, homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.3 X-RAY DIFFRACTION 0.250 0.234 False True IGHV1 None None None None None 6vsr A B 0 NA NA NA NA IMMUNE SYSTEM 02/11/20 Crystal structure of macaque anti-HIV-1 antibody RM20F MACACA MULATTA macaca mulatta macaca mulatta Oyen, D., Yuan, M., Wilson, I.A. 2.176 X-RAY DIFFRACTION 0.241 0.197 False True IGHV3 IGKV6 Kappa None None None None None 4n1c NA B 0 C protein lysozyme c Immune system/Hydrolase 10/03/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Roome, B., Stock, D., Christ, D. 1.7 X-RAY DIFFRACTION 0.233 0.197 False True IGKV1 Kappa None None None None None 4ydv H L 0 P peptide hiv gp41 peptide gp41(596-606) IMMUNE SYSTEM 02/23/15 STRUCTURE OF THE ANTIBODY 7B2 THAT CAPTURES HIV-1 VIRIONS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Nicely, N.I., Pemble IV, C.W. 2.7 X-RAY DIFFRACTION 0.223 0.189 False True IGHV3 IGKV4 Kappa None None None None None 5vta I G 0 B protein dipeptidyl peptidase 4 HYDROLASE 05/16/17 Co-Crystal Structure of DPPIV with a Chemibody Inhibitor RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Johnstone, S., Cheng, A. 2.8 X-RAY DIFFRACTION 0.300 0.250 False True IGHV1 IGKV4 Kappa None None None None None 7lja G F 0 B protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel FHEIG mutant A198E in a Tl+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.77 X-RAY DIFFRACTION 0.243 0.201 False True IGHV1 IGKV4 Kappa None None None None None 1ynk H L 0 H Hapten SC5 2-[((R)-{[4-(AMINOMETHYL)PHENYL]AMINO}{[(1R)-1-PHENYLETHYL]AMINO}METHYL)AMINO]ETHANE-1,1-DIOL IMMUNE SYSTEM 01/24/05 Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeteners: Crystal structure of NC6.8 co-crystalized with high potency sweetener compound SC45647 MUS MUSCULUS mus musculus mus musculus mus musculus Gokulan, K., Khare, S., Ronning, D.R., Linthicum, S.D., Sacchettini, J.C., Rupp, B. 2.1 X-RAY DIFFRACTION 0.277 0.213 False True IGHV1 IGKV1 Kappa None None None None None 3x3f H L 0 A protein tumor necrosis factor receptor superfamily member 10b APOPTOSIS/IMMUNE SYSTEM 01/20/15 TRAIL-R2 Extracellular Region Complexed to a Fab fragment from Human Agonist Antibody KMTR2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tamada, T. 2.1 X-RAY DIFFRACTION 0.224 0.186 False True IGHV1 IGKV3 Kappa None None None None None 4w2o A NA 0 B protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody B Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS (STRAIN MUSOKE-80) lama glama lake victoria marburgvirus (strain musoke-80) Taylor, A.B., Garza, J.A. 3.2 X-RAY DIFFRACTION 0.285 0.227 False True IGHV1 None None None None None 5zia G L 0 R peptide phosphorylated tau peptide IMMUNE SYSTEM 03/14/18 Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, H., Wilson, I.A. 2.603 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGKV4 Kappa 3e-07 -8.898798774188476 Unknown TBD 6cuf h l 0 c protein unknown VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 mus musculus mus musculus human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 7p02 H h 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/29/21 Human Neurokinin 1 receptor (NK1R) substance P Gs complex MUS MUSCULUS; HOMO SAPIENS mus musculus homo sapiens | homo sapiens | homo sapiens Thom, C., Ehrenmann, J., Vacca, S., Waltenspuhl, Y., Schoppe, J., Medalia, O., Pluckthun, A. 2.87 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6xcn H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/08/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6bi2 I M 0 IMMUNE SYSTEM 10/31/17 Trastuzumab Fab D185A (Light Chain) Mutant Biotin Conjugation. HOMO SAPIENS homo sapiens homo sapiens DiDonato, M., Spraggon, G. 1.801 X-RAY DIFFRACTION 0.202 0.166 False True IGHV3 IGKV1 Kappa None None None None None 7bel C D 0 X protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-88 and COVOX-45 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.53 X-RAY DIFFRACTION 0.286 0.249 False True IGHV3 IGKV1 Kappa None None None None None 5i16 H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1-69/IGKV3-11 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 1.9 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 IGKV3 Kappa None None None None None 6x08 K NA 0 B protein NA nucleoporin nup85 STRUCTURAL PROTEIN 05/15/20 Nup85-Seh1 from S. cerevisiae bound by VHH-SAN2 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 4.19 X-RAY DIFFRACTION 0.347 0.311 False True IGHV1 NA NA None None None None None 5vxr H L 0 P peptide virus envelope protein 2 IMMUNE SYSTEM 05/24/17 The antigen-binding fragment of MAb24 in complex with a peptide from Hepatitis C Virus E2 epitope I (412-423) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Hardy, J.M., Gu, J., Boo, I., Drummer, H.E., Coulibaly, F.J. 1.4 X-RAY DIFFRACTION 0.190 0.171 False False IGHV3 IGKV3 Kappa None None None None None 7my3 E NA 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/20/21 CryoEM structure of neutralizing nanobody Nb12 in complex with SARS-CoV2 spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Xu, K., Kwong, P.D. 2.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6okm H L 0 R protein tumor necrosis factor receptor superfamily member 4 IMMUNE SYSTEM 04/14/19 Human OX40R (TNFRSF4) bound to Fab 3C8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Boenig, G., Ultsch, M.H., Harris, S.F. 2.1 X-RAY DIFFRACTION 0.238 0.211 False True IGHV1 IGKV1 Kappa None None None None None 2r56 I M 0 B protein beta-lactoglobulin IMMUNE SYSTEM 09/03/07 Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Niemi, M., Kallio, J.M., Hakulinen, N., Rouvinen, J. 2.8 X-RAY DIFFRACTION 0.291 0.246 False False IGHV3 IGKV1 Kappa 1.30e-09 -12.12 SPR 17997967 7bej H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-158 Fab (crystal form 1) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.42 X-RAY DIFFRACTION 0.231 0.190 False True IGHV3 IGKV1 Kappa None None None None None 5x2o J K 0 C | D protein | protein NA | NA taste receptor, type 1, member 2a | taste receptor, type 1, member 3 SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-arginine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes | oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.6 X-RAY DIFFRACTION 0.272 0.185 False True IGHV1 IGKV3 Kappa None None None None None 3j42 K L 0 F protein prm VIRUS/IMMUNE SYSTEM 06/13/13 Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody MUS MUSCULUS; DENGUE VIRUS 2 mus musculus mus musculus dengue virus 2 Wang, Z., Pennington, J.G., Jiang, W., Rossmann, M.G. 21 ELECTRON MICROSCOPY False True IGHV5 IGKV6 Kappa None None None None None 7l2e H L 0 A protein NA spike glycoprotein Viral Protein/IMMUNE SYSTEM 12/16/20 Cryo-EM structure of NTD-directed neutralizing antibody 4-18 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 1g6v K NA 0 A protein carbonic anhydrase LYASE/IMMUNE SYSTEM 11/08/00 Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Desmyter, A., Decanniere, K., Muyldermans, S., Wyns, L. 3.5 X-RAY DIFFRACTION 0.276 0.210 False True IGHV1 7.20e-08 -9.74 SPR 11342547 6z7w D C 0 K | L peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Human insulin in complex with the analytical antibody HUI-018 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.42 X-RAY DIFFRACTION 0.275 0.209 False True IGHV1 IGKV6 Kappa None None None None None 4llu A B 0 IMMUNE SYSTEM 07/09/13 Structure of Pertuzumab Fab with light chain Clambda at 2.16A HOMO SAPIENS homo sapiens homo sapiens Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S. 2.16 X-RAY DIFFRACTION 0.273 0.222 False True IGHV3 IGKV1 Kappa None None None None None 7s0x C D 0 F protein NA circumsporozoite protein IMMUNE SYSTEM 08/31/21 Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.276 0.225 False True IGHV3 IGLV3 Lambda None None None None None 5gs3 H h 0 IMMUNE SYSTEM 08/13/16 Crystal structure of diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 1.698 X-RAY DIFFRACTION 0.211 0.192 True True unknown unknown unknown None None None None None 6cde H L 0 D protein glycoprotein 41 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6l8t C D 0 IMMUNE SYSTEM 11/07/19 Crystal structure of the Fab fragment of a humanized HBV therapeutic antibody HOMO SAPIENS homo sapiens homo sapiens He, M.Z., Gu, Y., Li, S.W. 1.766 X-RAY DIFFRACTION 0.192 0.165 False True IGHV3 IGKV1 Kappa None None None None None 6nb6 I M 0 B protein spike glycoprotein VIRUS 12/06/18 SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 1) SARS CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 4.2 ELECTRON MICROSCOPY False True IGHV3 IGKV2 Kappa None None None None None 7dcx B G 0 D protein NA sars-cov2 s protein VIRAL PROTEIN 10/27/20 S-3C1-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 3C1 fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 5.9 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 1g9e A NA 15 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 2qhr H L 0 P peptide envelope glycoprotein peptide Immune system/viral protein 07/02/07 Crystal structure of the 13F6-1-2 Fab fragment bound to its Ebola virus glycoprotein peptide epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Lee, J.E., Kuehne, A., Abelson, D.M., Fusco, M.L., Hart, M.K., Saphire, E.O. 2.0 X-RAY DIFFRACTION 0.245 0.203 False False IGHV5 IGLV3 Lambda 4.10e-08 -10.07 SPR 25 18005986 7zfe J K 0 A protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV3 IGKV3 Kappa None None None None None 5dup H L 0 A protein hemagglutinin IMMUNE SYSTEM 09/20/15 Influenza A virus H5 hemagglutinin globular head in complex with antibody AVFluIgG03 HOMO SAPIENS; INFLUENZA A VIRUS (A/ANHUI/1/2005(H5N1)) homo sapiens homo sapiens influenza a virus (a/anhui/1/2005(h5n1)) Zuo, T., Sun, J., Wang, G., Zhou, P., Wang, X., Zhang, L. 3.052 X-RAY DIFFRACTION 0.257 0.199 False True IGHV3 IGLV1 Lambda None None None None None 5fhc A B 0 J protein envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/15 Crystal Structure of Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP) HOMO SAPIENS; ZAIRE EBOLAVIRUS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) Gilman, M.S.A., McLellan, J.S. 6.704 X-RAY DIFFRACTION 0.343 0.260 False True IGHV4 IGLV3 Lambda None None None None None 7orb H L 0 R protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the L452R mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-75 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.5 X-RAY DIFFRACTION 0.251 0.213 False True IGHV1 IGKV3 Kappa None None None None None 5tlj F E 0 IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 3.5 X-RAY DIFFRACTION 0.356 0.283 False True IGHV1 IGKV3 Kappa None None None None None 7jkm H L 0 NA NA NA NA IMMUNE SYSTEM 07/28/20 REGN1 Human Fab in complex with anti-Kappa VHH domain HOMO SAPIENS; LAMA GLAMA homo sapiens homo sapiens Dennis, T.N., de la Cruz, M., Williams, J.C. 1.78 X-RAY DIFFRACTION 0.210 0.182 False True IGHV3 IGKV1 Kappa None None None None None 4hkb C D 0 IMMUNE SYSTEM 10/15/12 CH67 Fab (unbound) from the CH65-67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 3.6 X-RAY DIFFRACTION 0.306 0.258 False True IGHV1 IGLV3 Lambda None None None None None 4hc1 M N 0 B protein mucosal addressin cell adhesion molecule 1 IMMUNE SYSTEM 09/28/12 Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Springer, T., Yu, Y., Zhu, J. 2.871 X-RAY DIFFRACTION 0.253 0.200 False True IGHV3 IGKV14 Kappa None None None None None 4qex I M 0 B protein erythrocyte-binding antigen-175 IMMUNE SYSTEM 05/19/14 Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217 PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Chen, E., Paing, M.M., Salinas, N., Sim, B.K., Tolia, N.H. 4.5 X-RAY DIFFRACTION 0.285 0.232 False False IGHV1 IGKV3 Kappa None None None None None 5dsc E F 0 M peptide peptide IMMUNE SYSTEM 09/17/15 Context-independent anti-hypusine antibody FabHpu24.B in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Zhai, Q., Carter, P.J. 2.4 X-RAY DIFFRACTION 0.248 0.207 False True IGHV1 IGKV1 Kappa None None None None None 5nqw C NA 0 B protein immunoglobulin heavy constant epsilon IMMUNE SYSTEM 04/21/17 IgE-Fc in complex with single domain antibody 026 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Laursen, N.S., Jabs, F., Spillner, E., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.241 0.212 False True IGHV3 1.4e-09 -12.078842495721123 SPR TBD 3mlt H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.49 X-RAY DIFFRACTION 0.280 0.202 False False IGHV5 IGLV3 Lambda None None None None None 6osy H L 0 A protein bg505 gp41 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True IGHV4 IGKV1 Kappa None None None None None 2fb4 H L 0 IMMUNOGLOBULIN 04/18/89 DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L-KETTE, LAMBDA-TYP, SUBGRUPPE I (GERMAN) HOMO SAPIENS homo sapiens homo sapiens Marquart, M., Huber, R. 1.9 X-RAY DIFFRACTION unknown 0.189 False True IGHV3 IGLV1 Lambda None None None None None 7lq7 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 02/13/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 IGLV2 Lambda None None None None None 6k4z A a 0 a Hapten NPA 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID IMMUNE SYSTEM 05/27/19 Single-chain Fv antibody of C6 COMPLEXED WITH 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID MUS MUSCULUS mus musculus Nishiguchi, A., Numoto, N., Ito, N., Azuma, T., Oda, M. 1.65 X-RAY DIFFRACTION 0.196 0.167 True True unknown unknown unknown None None None None None 7qbf B NA 0 A protein NA transcobalamin-2 TRANSPORT PROTEIN 11/19/21 TC:CD320 in complex with nanobody TC-Nb34 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Bloch, J.S., Locher, K.P. 1.85 X-RAY DIFFRACTION 0.205 0.174 False True IGHV1 NA NA None None None None None 5mi0 B C 0 A protein reticulocyte binding-like protein 5,reticulocyte bindingprotein 5 IMMUNE SYSTEM 11/27/16 A thermally stabilised version of Plasmodium falciparum RH5 PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Campeotto, I., Goldenzweig, A., Davey, J., Barfod, L., Marshall, J.M., Silk, S.E., Wright, K.E., Draper, S.J., Higgins, M.K., Fleishman, S.J. 2.35 X-RAY DIFFRACTION 0.222 0.176 False True IGHV5 IGKV3 Kappa 4.0999999999999994e-07 -8.713721871255862 SPR TBD 4ma1 B C 0 IMMUNE SYSTEM 08/15/13 Unliganded 3 crystal structure of S25-26 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.32 X-RAY DIFFRACTION 0.260 0.229 False False IGHV2 IGKV1 Kappa None None None None None 5jor D A 0 NA NA NA NA IMMUNE SYSTEM 05/02/16 Crystal structure of unbound anti-glycan antibody Fab14.22 at 2.2 A MUS MUSCULUS mus musculus mus musculus Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A. 2.206 X-RAY DIFFRACTION 0.237 0.205 False True IGHV1 IGKV1 Kappa None None None None None 6nip H L 0 Z protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/31/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ1 in complex with ZIKV E glycoprotein HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 4.16 X-RAY DIFFRACTION 0.237 0.188 False True IGHV4 IGLV1 Lambda None None None None None 7r63 A NA 0 NA NA NA NA IMMUNE SYSTEM 06/22/21 Nb82, a nanobody against voltage gated sodium channels Nav1.4 and Nav1.5 LAMA GLAMA lama glama Srinivasan, L., Gabelli, S.B. 2.0 X-RAY DIFFRACTION 0.244 0.184 False True IGHV1 NA NA None None None None None 3ulu D C 0 A protein toll-like receptor 3 IMMUNE SYSTEM 11/11/11 Structure of quaternary complex of human TLR3ecd with three Fabs (Form1) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 3.52 X-RAY DIFFRACTION 0.309 0.268 False True IGHV6 IGLV3 Lambda None None None None None 3j8v F J 0 D protein NA l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.14J Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 13.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV13 Kappa None None None None None 6w51 O P 0 D | F protein | peptide NA | NA mhc class i antigen | cellular tumor antigen p53 peptide IMMUNE SYSTEM 03/12/20 Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Wright, K.M., Gabelli, S.B. 3.53 X-RAY DIFFRACTION 0.283 0.200 False True IGHV3 IGKV1 Kappa None None None None None 7tm0 E D 0 C protein NA spike glycoprotein VIRUS 01/19/22 SARS-CoV-2 S B.1.1.529 Omicron variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1vfb B A 0 C protein hen egg white lysozyme IMMUNOGLOBULIN/HYDROLASE(O-GLYCOSYL) 12/03/93 BOUND WATER MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN-ANTIBODY ASSOCIATION MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Bhat, T.N., Poljak, R.J. 1.8 X-RAY DIFFRACTION unknown 0.185 False True IGHV2 IGKV12 Kappa 3.70e-09 -11.47 ITC 24 8302837 2p42 D NA 0 C protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE3-mono-2 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 1.8 X-RAY DIFFRACTION 0.215 0.171 False True IGHV1 2.30e-08 -10.59 Other 30 18445622 3kj6 H L 0 A protein beta-2 adrenergic receptor SIGNALING PROTEIN 11/02/09 Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Bokoch, M.P., Zou, Y., Rasmussen, S.G.F., Liu, C.W., Nygaard, R., Rosenbaum, D.M., Fung, J.J., Choi, H.-J., Thian, F.S., Kobilka, T.S., Puglisi, J.D., Weis, W.I., Pardo, L., Prosser, S., Mueller, L., Kobilka, B.K. 3.4 X-RAY DIFFRACTION 0.280 0.238 False True IGHV1 IGKV14 Kappa None None None None None 6cde M N 0 C protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 4gw4 A B 0 IMMUNE SYSTEM 08/31/12 Crystal structure of 3BNC60 Fab with P61A mutation HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Fu, B.Z., Bjorkman, P.J. 2.65 X-RAY DIFFRACTION 0.256 0.213 False True IGHV1 IGKV1 Kappa None None None None None 7ra8 C D 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/30/21 SARS-CoV-2 S glycoprotein in complex with S2X259 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Veesler, D., Tortorici, M.A., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6xsk I K 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral Protein 07/15/20 Cryo-EM structure of vaccine-elicited Rhesus VH6-1 antibody 789-203-3C12 in complex with stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer MACACA MULATTA; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) macaca mulatta macaca mulatta influenza a virus (a/solomonislands/3/2006(h1n1)) | influenza a virus (a/solomonislands/3/2006(h1n1)) Cerutti, G., Gorman, J., Kwong, P.D., Shapiro, L. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6rp8 h l 0 c protein NA unknown IMMUNE SYSTEM 05/14/19 Crystal Structure of Ipilimumab Fab complexed with CTLA-4 at 2.6A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhang, F., Zhou, A. 2.6 X-RAY DIFFRACTION 0.267 0.211 False False IGHV3 IGKV3 Kappa None None None None None 7jkb B NA 0 NA NA NA NA IMMUNE SYSTEM 07/28/20 2xVH Fab HOMO SAPIENS homo sapiens Lord, D.M., Zhou, Y.F. 2.55 X-RAY DIFFRACTION 0.292 0.254 False True IGHV3 NA NA None None None None None 3hi6 H L 0 A protein integrin alpha-l cell adhesion/immune system 05/19/09 Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhang, H., Wang, J. 2.3 X-RAY DIFFRACTION 0.226 0.170 False True IGHV3 IGKV1 Kappa 4.70e-06 -7.26 SPR 19805116 2kqm NA A 4 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6awo B C 0 A protein NA sodium-dependent serotonin transporter TRANSPORT PROTEIN 09/06/17 X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Gouaux, E. 3.534 X-RAY DIFFRACTION 0.283 0.262 False True IGHV1 IGKV6 Kappa None None None None None 3upc A NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 7te1 H L 0 D protein NA spike protein s1 IMMUNE SYSTEM/Viral Protein 01/03/22 SARS-CoV-2 Receptor Binding Domain in Complex with Ab17 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hauser, B.M., Schmidt, A.G. 3.5 X-RAY DIFFRACTION 0.344 0.297 False True IGHV1 IGKV14 Kappa None None None None None 6n1w h l 0 d protein unknown VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False False IGHV4 IGKV1 Kappa None None None None None 7tpr H NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/22 Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Butay, K.J., Zhu, J., Dandey, V.P., Hong, J., Kwon, H.J., Chen, C.Z., Duan, Z., Li, D., Ren, H., Liang, T., Martin, N., Esposito, D., Ortega-Rodriguez, U., Xu, M., Xie, H., Ho, M., Cachau, R., Borgnia, M.J. 2.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7n0r D NA 0 B protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/25/21 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody C2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Ye, Q., Corbett, K.D. 1.42 X-RAY DIFFRACTION 0.166 0.141 False True IGHV3 NA NA None None None None None 6huj G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 10/08/18 CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38. BOS TAURUS; HOMO SAPIENS; LAMA GLAMA lama glama bos taurus, homo sapiens | homo sapiens Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R. 3.04 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6ikm K k 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 1q0x H L 0 IMMUNE SYSTEM 07/17/03 Anti-morphine Antibody 9B1 Unliganded Form MUS MUSCULUS mus musculus mus musculus Pozharski, E., Wilson, M.A., Hewagama, A., Shanafelt, A.B., Petsko, G., Ringe, D. 1.6 X-RAY DIFFRACTION 0.251 0.216 False True IGHV1 IGLV1 Lambda None None None None None 6u53 A NA 0 IMMUNE SYSTEM 08/26/19 Anti-Zaire ebolavirus Nucleoprotein Single Domain Antibody Zaire C (ZC) LAMA GLAMA lama glama Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 1.49 X-RAY DIFFRACTION 0.249 0.188 False True IGHV1 None None None None None 5lwf D NA 0 B protein beta-lactamase HYDROLASE 09/16/16 Structure of a single domain camelid antibody fragment cAb-G10S in complex with the BlaP beta-lactamase from Bacillus licheniformis BACILLUS LICHENIFORMIS; LAMA GLAMA lama glama bacillus licheniformis Vettore, N., Kerff, F., Pain, C., Herman, R., Sauvage, E., Preumont, S., Charlier, P., Dumoulin, M. 2.56 X-RAY DIFFRACTION 0.242 0.215 False True IGHV1 None None None None None 6kr0 D d 0 NA NA NA NA IMMUNE SYSTEM 08/20/19 Crystal structure of HL homo-diabody HOMO SAPIENS homo sapiens Tanaka, Y. 2.3 X-RAY DIFFRACTION 0.226 0.202 True True unknown unknown unknown None None None None None 6pzw F E 0 C protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-22 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 3k74 B NA 0 A protein dihydrofolate reductase OXIDOREDUCTASE 10/12/09 Disruption of protein dynamics by an allosteric effector antibody ESCHERICHIA COLI K-12; LAMA GLAMA lama glama escherichia coli k-12 Oyen, D., Srinivasan, V., Steyaert, J., Barlow, J. 1.95 X-RAY DIFFRACTION 0.240 0.196 False True IGHV1 None None None None None 4a6y B A 0 IMMUNE SYSTEM 11/10/11 CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI-(4-HYDROXY-3-NITROPHENYL) -ACETYL MURINE GERMLINE ANTIBODY BBE6.12H3 MUS MUSCULUS mus musculus mus musculus KHAN, T., SALUNKE, D.M. 2.9 X-RAY DIFFRACTION 0.26 0.24 False False IGHV1 IGLV1 Lambda None None None None None 1mcf NA A 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-b-ala-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 7s0x H L 0 E protein NA circumsporozoite protein IMMUNE SYSTEM 08/31/21 Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.276 0.225 False True IGHV3 IGLV3 Lambda None None None None None 5kel Q U 0 I protein ebola surface glycoprotein, gp2 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 ZAIRE EBOLAVIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV6 IGKV12 Kappa None None None None None 6kva h l 0 b peptide NA unknown IMMUNE SYSTEM 09/03/19 Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Xiang, J.C., Yan, L., Yang, B., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.235 0.194 False False IGHV1 IGLV5 Lambda None None None None None 6x5b I F 0 D protein NA envelope glycoprotein gp120 VIRAL PROTEIN 05/25/20 Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1oau J N 0 J Hapten DNF 2,4-DINITROPHENOL IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 1.8 X-RAY DIFFRACTION 0.264 0.226 False True IGHV1 IGLV1 Lambda 2.00e-08 Other 20 12610298 7x2d E NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/25/22 Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-Gs complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Teng, X., Zheng, S. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7lua i j 0 N carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS; HOMO SAPIENS homo sapiens homo sapiens Manne, K., Edwards, R.J., Acharya, P. 4.7 ELECTRON MICROSCOPY NA NA False False unknown IGKV2 Kappa None None None None None 4qhu B A 0 D protein interleukin-17a IMMUNE SYSTEM 05/29/14 Crystal Structure of IL-17A/Fab6785 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Malia, T., Obmolova, G., Teplyakov, A. 2.2 X-RAY DIFFRACTION 0.216 0.171 False True IGHV3 IGLV3 Lambda None None None None None 1a6t B A 0 IMMUNOGLOBULIN 03/03/98 FAB FRAGMENT OF MAB1-IA MONOCLONAL ANTIBODY TO HUMAN RHINOVIRUS 14 NIM-IA SITE MUS MUSCULUS mus musculus mus musculus Che, Z., Smith, T.J. 2.7 X-RAY DIFFRACTION 0.266 0.169 False False IGHV1 IGKV4 Kappa None None None None None 1qok a A 0 IMMUNOGLOBULIN 11/11/99 MFE-23 AN ANTI-CARCINOEMBRYONIC ANTIGEN SINGLE-CHAIN FV ANTIBODY MUS MUSCULUS mus musculus Boehm, M.K., Corper, A.L., Wan, T., Sohi, M.K., Sutton, B.J., Thornton, J.D., Keep, P.A., Chester, K.A., Begent, R.H.J., Perkins, S.J. 2.4 X-RAY DIFFRACTION 0.267 0.205 True True unknown unknown unknown None None None None None 6nqd K L 0 J | I protein | protein NA | NA t/f100 env gp41 | t/f100 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/21/19 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Fang, Q., Rossmann, M.G. 3.9 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6n51 D NA 0 B protein metabotropic glutamate receptor 5 MEMBRANE PROTEIN 11/20/18 Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K. 4 ELECTRON MICROSCOPY False True IGHV1 None None None None None 5uk2 H h 0 C protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 4 INFLUENZA A VIRUS; HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 1ggi H L 0 P peptide hiv-1 v3 loop peptide antigen IMMUNOGLOBULIN 04/02/93 CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN MUS MUSCULUS mus musculus Stanfield, R.L., Rini, J.M., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.188 False True IGHV8 IGKV3 Kappa None None None None None 4ypg B A 0 C protein interferon alpha-2 IMMUNE SYSTEM 03/12/15 Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oganesyan, V., Dall'Acqua, W.F. 3.0 X-RAY DIFFRACTION 0.272 0.206 False True IGHV1 IGKV3 Kappa 4.3999999999999997e-11 -14.128858472801308 SPR TBD 6x3x J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 2.92 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 7wwl J N 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/13/22 S protein of Delta variant in complex with ZWD12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6mfp H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 09/11/18 Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Young, B., Pazgier, M. 3.0 X-RAY DIFFRACTION 0.274 0.214 False True IGHV1 IGKV1 Kappa None None None None None 7n9t D NA 0 C protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/18/21 CryoEM structure of SARS-CoV-2 Spike in complex with Nb17 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4xx1 H L 0 A protein phosphatidylcholine-sterol acyltransferase Hydrolase/Immune system 01/29/15 Low resolution structure of LCAT in complex with Fab1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T. 3.6 X-RAY DIFFRACTION 0.280 0.196 False True IGHV3 IGLV3 Lambda None None None None None 5i1a B A 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV3-11 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.0 X-RAY DIFFRACTION 0.255 0.206 False True IGHV3 IGKV3 Kappa None None None None None 4w2p B NA 0 IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C LAMA GLAMA lama glama Taylor, A.B., Garza, J.A. 1.77 X-RAY DIFFRACTION 0.203 0.165 False True IGHV1 None None None None None 2qtj A L 5 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4ckd H L 0 C protein beta-galactosidase HYDROLASE/IMMUNE SYSTEM 01/03/14 Model of complex between the E.coli enzyme beta-galactosidase and four single chain Fv antibody domains scFv13R4. MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Vinothkumar, K.R., McMullan, G., Henderson, R. 13.0 ELECTRON MICROSCOPY False True IGHV3 IGKV5 Kappa None None None None None 2ltq F E 9 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 6nms B A 0 C protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Blocking Fab 136 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.11 X-RAY DIFFRACTION 0.244 0.204 False True IGHV3 IGKV3 Kappa None None None None None 4cad E D 0 F protein ras and a-factor converting enzyme 1, rce1 PROTEIN BINDING 10/08/13 Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 METHANOCOCCUS MARIPALUDIS; MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis Kulkarni, K., Manolaridis, I., Dodd, R.B., Cronin, N., Ogasawara, S., Iwata, S., Barford, D. 2.5 X-RAY DIFFRACTION 0.2669 0.2262 False False IGHV1 IGKV12 Kappa None None None None None 4yr6 A B 0 C peptide ace-lys-leu-arg-gly-val-leu-gln-gly-his-leu IMMUNE SYSTEM 03/14/15 Fab fragment of 5G6 in complex with epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tao, Y., Mo, X., Li, R. 2.38 X-RAY DIFFRACTION 0.251 0.212 False False IGHV8 IGKV12 Kappa None None None None None 7nd4 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-88 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 6bpb A B 0 IMMUNE SYSTEM 11/22/17 Plasmodium vivax invasion blocking monoclonal antibody 4F7 MUS MUSCULUS mus musculus mus musculus Gruszczyk, J., Chan, L.J., Tham, W.H. 1.87 X-RAY DIFFRACTION 0.219 0.206 False False IGHV5 IGKV6 Kappa None None None None None 3q3g K J 0 L protein integrin alpha-m IMMUNE SYSTEM/CELL ADHESION 12/21/10 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 2.7 X-RAY DIFFRACTION 0.244 0.211 False False IGHV14 IGKV8 Kappa 4.97e-09 -11.32 SPR 25 22095715 5gzr M N 0 VIRUS 10/01/16 Zika virus E protein complexed with a neutralizing antibody Z23-Fab HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens Gao, G.G., Shi, Y., Peng, R., Liu, S. 9.4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 2ltq F E 0 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 7r74 D NA 0 A protein NA glycoprotein 120 IMMUNE SYSTEM 06/24/21 Crystal structure of llama VHH antibody in complex with HIV-1 HXBC2 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.76 X-RAY DIFFRACTION 0.270 0.212 False True IGHV1 NA NA None None None None None 3bj9 NA 1 0 IMMUNE SYSTEM 12/03/07 Crystal structure of the Surrogate Light Chain Variable Domain VpreBJ HOMO SAPIENS homo sapiens Morstadt, L.M., Bohm, A.A., Stollar, B.D., Baleja, J.D. 2.0 X-RAY DIFFRACTION 0.230 0.181 False True unknown unknown unknown None None None None None 6ev1 K L 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Dubel, S., Blankenfeldt, W., Rau, U. 3.043 X-RAY DIFFRACTION 0.238 0.186 False True IGHV1 IGKV4 Kappa None None None None None 3opz I M 0 B protein trans-sialidase hydrolase/immune system 09/02/10 Crystal structure of trans-sialidase in complex with the Fab fragment of a neutralizing monoclonal IgG antibody TRYPANOSOMA CRUZI; MUS MUSCULUS mus musculus mus musculus trypanosoma cruzi Larrieux, N., Muia, R., Campetella, O., Buschiazzo, A. 3.4 X-RAY DIFFRACTION 0.205 0.164 False False IGHV1 IGKV4 Kappa None None None None None 1rzg C D 0 IMMUNE SYSTEM 12/24/03 Crystal structure of Human anti-HIV-1 GP120 reactive antibody 412d HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.251 0.201 False True IGHV1 IGKV1 Kappa None None None None None 2b1h H L 0 P peptide ug29 peptide of exterior membrane glycoprotein gp120 IMMMUNE SYSTEM 09/15/05 Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Stanfield, R.L., Gorny, M.K., Zolla-Pazner, S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.238 0.205 False False IGHV5 IGLV1 Lambda None None None None None 3t0w NA A 0 A Hapten DIW 1-(3-SULFOPROPYL)-4-[(1E,3E)-3-(1,3,3-TRIMETHYL-1,3-DIHYDRO-2H-INDOL-2-YLIDENE)PROP-1-EN-1-YL]QUINOLINIUM DYE-BINDING PROTEIN 07/20/11 Fluorogen activating protein M8VL in complex with dimethylindole red HOMO SAPIENS homo sapiens homo sapiens Stanfield, R., Senutovitch, N., Bhattacharyya, S., Rule, G., Wilson, I.A., Armitage, B., Waggoner, A.S., Berget, P. 1.501 X-RAY DIFFRACTION 0.183 0.148 False True IGLV1 Lambda 5.0000000000000004e-08 -9.960387018191561 Unknown TBD 1maj NA A 10 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6vel H L 0 C protein ubiquitin-like protein, smt3,cadherin-1 chimera CELL ADHESION/Immune System 01/02/20 Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody 66E8Fab MUS MUSCULUS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); HOMO SAPIENS mus musculus mus musculus saccharomyces cerevisiae (strain atcc 204508 /s288c), homo sapiens Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.65 X-RAY DIFFRACTION 0.233 0.183 False True IGHV1 IGKV16 Kappa None None None None None 5lbs H L 0 A protein envelope protein e IMMUNE SYSTEM-VIRAL PROTEIN 06/17/16 structural basis of Zika and Dengue virus potent antibody cross-neutralization ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus VANEY, M.C., ROUVINSKI, A., BARBA-SPAETH, G., REY, F.A. 2.41 X-RAY DIFFRACTION 0.217 0.194 False True IGHV3 IGKV3 Kappa None None None None None 6s3t N M 0 A protein 46 kda surface antigen PROTEIN BINDING 06/26/19 P46, an immunodominant surface protein from Mycoplasma hyopneumoniae MYCOPLASMA HYOPNEUMONIAE J; MUS MUSCULUS mus musculus mus musculus mycoplasma hyopneumoniae j Guasch, A., Fita, I. 3.5 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 7pc2 G H 0 C protein NA gp120, bg505 sosip.664 t332n VIRAL PROTEIN 08/03/21 HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Fernandez, I., Bontems, F., Pehau-Arnaudet, G., Rey, F. 2.8 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 3vi3 F E 0 B protein integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 09/21/11 Crystal structure of alpha5beta1 integrin headpiece (ligand-free form) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nagae, M., Nogi, T., Takagi, J. 2.9 X-RAY DIFFRACTION 0.267 0.207 False True IGHV1 IGKV2 Kappa None None None None None 7ws1 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7lue J N 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 02/22/21 Prefusion RSV F glycoprotein bound by neutralizing site V-directed antibody ADI-14442 RESPIRATORY SYNCYTIAL VIRUS A2; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus a2 Gilman, M.S.A., McLellan, J.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 7oau B NA 0 A protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody C5 bound to Kent variant RBD (N501Y) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 1.65 X-RAY DIFFRACTION 0.199 0.175 False False IGHV1 NA NA None None None None None 2vdm H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Tirofiban HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.9 X-RAY DIFFRACTION 0.206 0.167 False False IGHV14 IGKV14 Kappa None None None None None 6mhg G S 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7dv4 H NA 0 G protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 01/12/21 Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 HOMO SAPIENS homo sapiens homo sapiens Li, H., Gan, X., He, Y. 2.38 X-RAY DIFFRACTION 0.258 0.221 False True IGHV3 NA NA None None None None None 6adc E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148A mutant CLC-ec1 in the presence of 50mM bromoacetate ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 3.055 X-RAY DIFFRACTION 0.275 0.226 False False IGHV4 IGKV4 Kappa None None None None None 6pxg C D 0 IMMUNE SYSTEM 07/26/19 Crystal Structure of MERS-CoV neutralizing antibody G2 Fab MUS MUSCULUS mus musculus mus musculus Wang, N., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.225 0.181 False True IGHV1 IGKV3 Kappa None None None None None 6opo H L 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7mta H L 4 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5drz H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 09/16/15 Crystal structure of anti-HIV-1 antibody F240 Fab in complex with gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 m Gohain, N., Tolbert, W.D., Pazgier, M. 2.54 X-RAY DIFFRACTION 0.259 0.204 False True IGHV3 IGKV4 Kappa 4.4000000000000005e-09 -11.400370293980798 Unknown TBD 7sp9 C NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus Hyaluronan Synthase in the GlcNAc-primed channel-closed state LAMA GLAMA; PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 8fab B A 0 IMMUNOGLOBULIN 03/23/92 CRYSTAL STRUCTURE OF THE FAB FRAGMENT FROM THE HUMAN MYELOMA IMMUNOGLOBULIN IGG HIL AT 1.8 ANGSTROMS RESOLUTION HOMO SAPIENS homo sapiens homo sapiens Saul, F.A., Poljak, R.J. 1.8 X-RAY DIFFRACTION unknown 0.173 False False IGHV3 IGLV3 Lambda None None None None None 1mak NA A 0 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5x0t A B 0 E protein basigin IMMUNE SYSTEM 01/23/17 Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Lin, P., Zhang, M.-Y., Ye, S., Chen, X., Yu, X.-L., Zhang, R.-G., Zhu, P., Chen, Z.-N. 2.5 X-RAY DIFFRACTION 0.300 0.246 False True IGHV6 IGKV6 Kappa None None None None None 6mhg A N 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7a4d A NA 0 E peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 4fp8 I M 0 B protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/21/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.947 X-RAY DIFFRACTION 0.241 0.212 False True IGHV3 IGKV1 Kappa None None None None None 3ks0 K J 0 A protein cytochrome b2, mitochondrial OXIDOREDUCTASE 11/20/09 Crystal structure of the heme domain of flavocytochrome b2 in complex with Fab B2B4 SACCHAROMYCES CEREVISIAE; MUS MUSCULUS mus musculus mus musculus saccharomyces cerevisiae Golinelli-Pimpaneau, B., Lederer, F., Le, K.H.D. 2.7 X-RAY DIFFRACTION 0.289 0.214 False False IGHV3 IGLV1 Lambda None None None None None 7fci H L 0 A protein NA sodium/bile acid cotransporter TRANSPORT PROTEIN/IMMUNE SYSTEM 07/14/21 human NTCP in complex with YN69083 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Park, J.H., Iwamoto, M., Yun, J.H., Uchikubo-Kamo, T., Son, D., Jin, Z., Yoshida, H., Ohki, M., Ishimoto, N., Mizutani, K., Oshima, M., Muramatsu, M., Wakita, T., Shirouzu, M., Liu, K., Uemura, T., Nomura, N., Iwata, S., Watashi, K., Tame, J.R.H., Nishizawa, T., Lee, W., Park, S.Y. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 4p9m H L 0 NA NA NA NA IMMUNE SYSTEM 04/04/14 Crystal structure of 8ANC195 Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 2.13 X-RAY DIFFRACTION 0.239 0.211 False True unknown IGKV1 Kappa None None None None None 6v4n C G 0 M protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 1G05 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6tyl H NA 0 F protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 08/09/19 Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., McClelland, L., Yates-Hansen, C., Sprang, S.R. 3.3 X-RAY DIFFRACTION 0.287 0.248 False True IGHV1 None None None None None 6d0u H I 0 G protein hemagglutinin ANTIVIRAL PROTEIN 04/11/18 Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Wu, N.C., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.268 0.254 False True IGHV3 IGKV1 Kappa None None None None None 2vwe E C 0 A protein vascular endothelial growth factor b IMMUNE SYSTEM 06/23/08 Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Leonard, P., Scotney, P.D., Jabeen, T., Iyer, S., Fabri, L.J., Nash, A.D., Acharya, K.R. 3.4 X-RAY DIFFRACTION 0.310 0.262 False True IGHV1 IGKV10 Kappa 1.14e-10 -13.56 SPR 18930733 6nb7 H L 0 A protein spike glycoprotein VIRUS 12/06/18 SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2) SARS CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 4.5 ELECTRON MICROSCOPY False True IGHV3 IGKV2 Kappa None None None None None 6zwk F NA 0 L peptide NA histone h2ax IMMUNE SYSTEM 07/28/20 Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens McEwen, A.G., Moeglin, E., Desplancq, D., Weiss, E., Poterszman, A. 1.55 X-RAY DIFFRACTION 0.184 0.149 False True IGHV1 NA NA None None None None None 4at6 H L 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 4w2q G NA 0 H protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS lama glama lake victoria marburgvirus Taylor, A.B., Garza, J.A. 2.7 X-RAY DIFFRACTION 0.274 0.220 False True IGHV1 None None None None None 7khf A L 0 F carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/21/20 CryoEM structure of LILRB1 D3D4 domain-inserted antibody MDB1 Fab in complex with Plasmodium RIFIN (PF3D7_1373400) V2 domain HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens Xu, K., Kwong, P.D. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 6wxl K J 0 I | G protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 05/11/20 Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer INFLUENZA A VIRUS (A/SHANGHAI/JS01/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/shanghai/js01/2013(h7n9)) | influenza a virus (a/shanghai/js01/2013(h7n9)) Gorman, J., Kwong, P.D. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 1yy8 D C 0 IMMUNE SYSTEM 02/24/05 Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Li, S., Schmitz, K.R., Jeffrey, P.D., Wiltzius, J.J.W., Kussie, P., Ferguson, K.M. 2.0 X-RAY DIFFRACTION 0.264 0.224 False True IGHV2 IGKV5 Kappa None None None None None 2gfb J I 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 7vgy E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/20/21 Melatonin receptor1-2-Iodomelatonin-Gicomplex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; MUS MUSCULUS mus musculus homo sapiens | rattus norvegicus Wang, Q.G., Lu, Q.Y. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1n4x H L 0 Immune system 11/02/02 Structure of scFv 1696 at acidic pH MUS MUSCULUS mus musculus mus musculus Lescar, J., Brynda, J., Fabry, M., Horejsi, M., Rezacova, P., Sedlacek, J., Bentley, G.A. 1.7 X-RAY DIFFRACTION 0.256 0.227 False True IGHV9 IGKV1 Kappa None None None None None 6vmj F E 0 Y protein NA complement factor d HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 2.95 X-RAY DIFFRACTION 0.265 0.218 False True IGHV1 IGKV1 Kappa None None None None None 6p3s C D 0 E protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 5ifj J K 0 L peptide peptide pro-leu-gln-pro-glu-gln-pro-phe-pro IMMUNE SYSTEM 02/26/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPEQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens triticum aestivum Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 2.35 X-RAY DIFFRACTION 0.241 0.205 False True IGHV3 IGLV4 Lambda None None None None None 4k3e I M 0 IMMUNE SYSTEM 04/10/13 Crystal structure of bovine antibody BLV5B8 with ultralong CDR H3 BOS TAURUS bos taurus bos taurus Ekiert, D.C., Wang, F., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.240 0.202 False True IGHV1 IGLV1 Lambda None None None None None 2kqn NA A 11 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7tp3 H L 0 Z protein NA spike protein s1 IMMUNE SYSTEM 01/24/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K288.2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MACACA MULATTA macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.33 X-RAY DIFFRACTION 0.231 0.185 False True IGHV3 IGKV3 Kappa None None None None None 1q72 H L 0 H Hapten COC COCAINE IMMUNE SYSTEM 08/15/03 Anti-Cocaine Antibody M82G2 Complexed with Cocaine MUS MUSCULUS mus musculus mus musculus mus musculus Pozharski, E., Moulin, A., Hewagama, A., Shanafelt, A.B., Petsko, G.A., Ringe, D. 1.7 X-RAY DIFFRACTION 0.249 0.218 False False IGHV6 IGKV2 Kappa 1.4e-07 -9.350354316900614 Unknown TBD 6gfe H L 0 IMMUNE SYSTEM 04/30/18 High-resolution Structure of a therapeutic full-length anti-NPRA Antibody with exceptional Conformational Diversity HOMO SAPIENS homo sapiens homo sapiens Hoerer, S. 1.8 X-RAY DIFFRACTION 0.200 0.181 False True IGHV6 IGKV3 Kappa None None None None None 1rei NA B 0 IMMUNOGLOBULIN(PART)SEQUESTERS ANTIGENS 03/17/76 THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION HOMO SAPIENS homo sapiens Epp, O., Lattman, E.E., Colman, P., Fehlhammer, H., Bode, W., Schiffer, M., Huber, R., Palm, W. 2.0 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 7aj6 H L 0 NA NA NA NA IMMUNE SYSTEM 09/28/20 LN02 Fab HOMO SAPIENS homo sapiens homo sapiens Caillat, C., Fenwick, G., Pantaleo, G., Weissenhorn, W. 1.9 X-RAY DIFFRACTION 0.214 0.177 False True unknown unknown unknown None None None None None 6h3t I M 0 B protein envelopment polyprotein VIRAL PROTEIN 07/19/18 Schmallenberg Virus Glycoprotein Gc Head Domain in Complex with scFv 1C11 MUS MUSCULUS; BOVINE SCHMALLENBERG VIRUS mus musculus mus musculus bovine schmallenberg virus Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A. 2.836 X-RAY DIFFRACTION 0.262 0.213 False True IGHV1 IGKV8 Kappa None None None None None 1nj9 B A 0 IMMUNE SYSTEM 12/30/02 Cocaine hydrolytic antibody 15A10 MUS MUSCULUS mus musculus mus musculus Larsen, N.A., de Prada, P., Deng, S.X., Zhu, X., Landry, D.W., Wilson, I.A. 2.35 X-RAY DIFFRACTION 0.283 0.199 False False IGHV1 IGLV1 Lambda None None None None None 5vm4 H NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 5uoe M N 0 B protein insulin-degrading enzyme Hydrolase/Immune System 01/31/17 Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J. 3.8 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7r8m H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C032 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 DeLaitsch, A.T., Barnes, C.O., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 7rga F NA 0 F Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoCLAMP3:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Alexandrov, K. 2.9 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 4s10 B NA 0 D protein gelsolin METAL BINDING PROTEIN/IMMUNE SYSTEM 01/07/15 Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Wongsantichon, J., Robinson, R.C., Gettemans, J. 2.614 X-RAY DIFFRACTION 0.312 0.223 False True IGHV1 None None None None None 4ers H L 0 A protein glucagon receptor IMMUNE SYSTEM 04/20/12 A Molecular Basis for Negative Regulation of the Glucagon Receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murray, J.M., Koth, C.M., Mukund, S. 2.637 X-RAY DIFFRACTION 0.279 0.231 False True IGHV3 IGKV1 Kappa None None None None None 2vc2 H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 09/18/07 Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 3.1 X-RAY DIFFRACTION 0.217 0.177 False False IGHV14 IGKV14 Kappa None None None None None 7eh5 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/28/21 Cryo-EM structure of SARS-CoV-2 S-D614G variant in complex with neutralizing antibodies, RBD-chAb15 and RBD-chAb45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Chang, Y.C., Wu, H.C., Hsu, S.T.D. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 5hj3 M N 0 L | K protein | protein NA | NA envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/12/16 Crystal structure of host-primed Ebola virus GP, GPcl. EBOLA VIRUS SP.; ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus | ebola virus sp. Bornholdt, Z.A., Fusco, M.L., Saphire, E.O. 3.3 X-RAY DIFFRACTION 0.258 0.227 False True IGHV3 IGKV4 Kappa None None None None None 5lve NA A 0 IMMUNE SYSTEM 02/24/99 STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.-B., Chang, C.-H. 2.0 X-RAY DIFFRACTION 0.218 0.186 False True IGKV4 Kappa None None None None None 7luc F G 0 A protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/22/21 Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B RESPIRATORY SYNCYTIAL VIRUS; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus Wrapp, D., McLellan, J.S. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 6o29 H L 0 D peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein NPDP and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.240 0.201 False True IGHV3 IGKV3 Kappa None None None None None 7f3q H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/16/21 SARS-CoV-2 RBD in complex with A5-10 Fab and A34-2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dou, Y., Wang, X., Liu, P., Lu, B., Wang, K. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 1mh5 H L 0 H Hapten HAL N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE IMMUNE SYSTEM 08/19/02 The Structure Of The Complex Of The Fab Fragment Of The Esterolytic Antibody MS6-164 and A Transition-State Analog MUS MUSCULUS mus musculus mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 2.1 X-RAY DIFFRACTION 0.288 0.218 False True IGHV1 IGKV2 Kappa 6.100000000000001e-10 -12.571059308451574 Unknown TBD 6xp6 H G 0 A | C | B protein | peptide | protein NA | NA | NA mhc class ii hla-dq-alpha chain | dq2-glia-a2 peptide | mhc class ii hla-dq-beta-1 PEPTIDE BINDING PROTEIN 07/08/20 3C11-DQ2-glia-a2 complex HOMO SAPIENS; TRITICUM AESTIVUM homo sapiens homo sapiens homo sapiens | triticum aestivum | homo sapiens Petersen, J., Rossjohn, J. 2.4 X-RAY DIFFRACTION 0.212 0.176 False True IGHV1 IGKV1 Kappa None None None None None 7p78 H NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 1up/1up-out/1down conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3qq9 D C 0 IMMUNE SYSTEM 02/15/11 Crystal structure of FAB fragment of anti-human RSV (RESPIRATORY SYNCYTIAL VIRUS) F Protein MAB 101F HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Luo, J., Tsui, P., Spurlino, J., Lewansowski, F., Heavner, G.A., Del Vecchio, F. 1.64 X-RAY DIFFRACTION 0.217 0.173 False True IGHV8 IGKV3 Kappa None None None None None 7chh J K 0 C protein NA spike glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with BD-368-2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J., Zhu, Q., Wang, G. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 5m2m J NA 0 I protein tumor necrosis factor CYTOKINE 10/13/16 Complex between human TNF alpha and Llama VHH3 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.3 X-RAY DIFFRACTION 0.248 0.211 False True IGHV1 1.5000000000000002e-09 -12.037965345328766 SPR TBD 6vun B b 0 NA NA NA NA PROTEIN BINDING 02/16/20 Reverse Transcriptase Diabody with R83C Mutation HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 1.4 X-RAY DIFFRACTION 0.167 0.138 True True unknown unknown unknown None None None None None 6pz8 C G 0 J protein s protein VIRAL PROTEIN/IMMUNE SYSTEM 07/31/19 MERS S0 trimer in complex with variable domain of antibody G2 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Bowman, C.A., Pallesen, J., Ward, A.B. 4.19 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 2x89 A NA 0 D protein beta-2-microglobulin IMMUNE SYSTEM 03/07/10 Structure of the Beta2_microglobulin involved in amyloidogenesis HOMO SAPIENS; CAMELUS DROMEDARIUS homo sapiens homo sapiens Domanska, K., Srinivasan, V., Vanderhaegen, S., Pardon, E., Marquez, J.A., Bellotti, V., Wyns, L., Steyaert, J. 2.16 X-RAY DIFFRACTION 0.26691 0.23813 False True IGHV3 4.40e-08 -10.03 SPR 21220305 4yaq A B 0 B carbohydrate NAG polysaccharide IMMUNE SYSTEM 02/17/15 Crystal structure of a computationally optimized PG9 mutant HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murrell, S., Julien, J.P., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.238 0.204 False True IGHV3 IGLV2 Lambda None None None None None 7we9 H J 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv289 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7rew A B 0 G protein NA il13 CYTOKINE 07/13/21 Crystal Structure of IL-13 in complex with MMAb3 Fab HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Sudom, A., Min, X. 2.1 X-RAY DIFFRACTION 0.291 0.245 False True IGHV3 IGLV3 Lambda None None None None None 6r0x C D 0 F protein megakaryocyte and platelet inhibitory receptor g6b BLOOD CLOTTING 03/13/19 The extracellular domain of G6b-B in complex with Fab fragment and DP12 heparin oligosaccharide. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ogg, D.J., McMiken, H.J., Howard, T.D. 3.13 X-RAY DIFFRACTION 0.266 0.230 False True IGHV14 IGKV10 Kappa None None None None None 1zea H L 0 A peptide short synthetic d-amino acid peptide d2 IMMUNE SYSTEM 04/18/05 Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Scheerer, P., Krauss, N., Wessner, H., Scholz, C., Otte, L., Seifert, M., Kramer, A., Schneider-Mergener, J., Hoehne, W. 1.78 X-RAY DIFFRACTION 0.248 0.198 False False IGHV9 IGKV1 Kappa 6e-06 -7.123876292458442 Unknown TBD 4nc1 D NA 0 B protein cell wall-binding repeat protein IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A2 Bound to A20.1 VHH and A26.8 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 2.61 X-RAY DIFFRACTION 0.252 0.202 False True IGHV1 None None None None None 6hjy J NA 0 E protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.78 X-RAY DIFFRACTION 0.233 0.225 False True IGHV1 None None None None None 3dvn B A 0 Y | X protein | protein NA | NA ubiquitin | ubiquitin d77 IMMUNE SYSTEM 07/18/08 Crystal structure of K63-specific fab Apu2.16 bound to K63-linked di-ubiquitin HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Hymowitz, S.G. 2.7 X-RAY DIFFRACTION 0.268 0.220 False True IGHV3 IGKV1 Kappa 9.20e-08 -9.59 SPR 18724939 7m1h D NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/13/21 Crystal structure of LC/A-JPU-C10-JPU-D12-JPU-B8-JPU-G3-ciA-F12-ciA-D12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.78 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 NA NA None None None None None 1bjm NA A 0 IMMUNOGLOBULIN 05/26/95 LOC NAKS, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN NAKSO4 HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.2 X-RAY DIFFRACTION unknown unknown False False IGLV1 Lambda None None None None None 6z2m B C 0 A protein spike glycoprotein VIRAL PROTEIN 06/03/20 H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Naismith, J.H., Ren, J., Zhou, D., Zhao, Y., Stuart, D.I. 2.71 X-RAY DIFFRACTION 0.241 0.198 False True IGHV5 IGKV4 Kappa None None None None None 4kro B NA 0 A protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 3.054 X-RAY DIFFRACTION 0.280 0.221 False True IGHV1 2.7600000000000004e-07 -8.948201016697006 SPR TBD 6q1j H L 0 IMMUNE SYSTEM 08/05/19 Antibody H2227 from the human antibody lineage 652 HOMO SAPIENS homo sapiens homo sapiens McCarthy, K.R., Harrison, S.C., Raymond, D.D. 2.703 X-RAY DIFFRACTION 0.246 0.225 False True IGHV4 IGLV3 Lambda None None None None None 6oao L l 0 K protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 092096 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 3.497 X-RAY DIFFRACTION 0.279 0.238 True True unknown unknown unknown None None None None None 2kqm NA B 13 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5ibl C D 0 F protein NA hemagglutinin IMMUNE SYSTEM 02/22/16 Human antibody 6639 in complex with influenza hemagglutinin H1 X-181 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Raymond, D.D., Harrison, S.C. 3.39 X-RAY DIFFRACTION 0.257 0.214 False True IGHV5 IGKV3 Kappa None None None None None 7bm5 F E 0 NA NA NA NA IMMUNE SYSTEM 01/19/21 Crystal structure of Fab1, the Fab fragment of the anti-BamA monoclonal antibody MAB1 HOMO SAPIENS homo sapiens homo sapiens White, P., Storek, K.M., Rutherford, S.T., Radford, S.E. 2.95 X-RAY DIFFRACTION 0.290 0.257 False True IGHV5 IGKV12 Kappa None None None None None 6rco A B 0 IMMUNE SYSTEM 04/11/19 PfRH5-binding monoclonal antibody R5.004 HOMO SAPIENS homo sapiens homo sapiens Alanine, D.G.W., Draper, S.J., Higgins, M.K. 1.66 X-RAY DIFFRACTION 0.204 0.183 False True IGHV1 IGLV1 Lambda None None None None None 7wue C D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/22 Crystal structure of SARS-CoV-2 Receptor Binding Domain in complex with the monoclonal antibody m31A7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Mohapatra, A. 3.2 X-RAY DIFFRACTION 0.295 0.228 False True IGHV1 IGKV8 Kappa None None None None None 2qtj C N 0 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4orz C NA 0 B protein protein nef TRANSFERASE/APOPTOSIS/IMMUNE SYSTEM 02/12/14 HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain LAMA GLAMA; HOMO SAPIENS; HIV-1 M:B_ARV2/SF2 lama glama hiv-1 m Geyer, M., Lulf, S. 2.0 X-RAY DIFFRACTION 0.236 0.202 False True IGHV1 None None None None None 7cyv H h 0 B protein NA spike protein s1 VIRAL PROTEIN 09/04/20 Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens severe acute respiratory syndrome coronavirus2 Li, Y., Li, T., Lai, Y., Cai, H., Yao, H., Li, D. 3.13 X-RAY DIFFRACTION 0.276 0.252 True True unknown unknown unknown None None None None None 5a2i H h 0 P peptide antigen tn, ser is covalently bound to galnac IMMUNE SYSTEM 05/20/15 Crystal structure of scFv-SM3 in complex with APD-SGalNAc-RP MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Martinez-Saez, N., Castro-Lopez, J., Valero-Gonzalez, J., Madariaga, D., Companon, I., Somovilla, V.J., Salvado, M., Asensio, J.L., Jimenez-Barbero, J., Avenoza, A., Busto, J.H., Bernardes, G.J.L., Peregrina, J.M., Hurtado-Guerrero, R., Corzana, F. 1.88 X-RAY DIFFRACTION 0.26131 0.20598 True True unknown unknown unknown 8.8e-06 -6.896959633430256 Unknown TBD 7rth N M 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 4qhm C D 0 IMMUNE SYSTEM 05/28/14 I3.1 (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.23 X-RAY DIFFRACTION 0.251 0.224 False True IGHV4 IGLV3 Lambda None None None None None 7s6j C D 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 09/14/21 J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7mw3 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7mdj A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 04/05/21 The structure of KcsA in complex with a synthetic Fab SYNTHETIC CONSTRUCT; STREPTOMYCES LIVIDANS synthetic construct synthetic construct streptomyces lividans Rohaim, A., Slezak, T., Blackowicz, L., Kossiakoff, A., Roux, B. 2.75 X-RAY DIFFRACTION 0.265 0.201 False True IGHV3 IGKV1 Kappa None None None None None 5ig7 G H 0 I peptide peptide pro-leu-gln-pro-gln-gln-pro-phe-pro IMMUNE SYSTEM 02/27/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPQQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.97 X-RAY DIFFRACTION 0.236 0.190 False True IGHV3 IGLV4 Lambda None None None None None 5cus J N 0 C protein receptor tyrosine-protein kinase erbb-3 TRANSFERASE 07/25/15 Crystal Structure of sErbB3-Fab3379 Complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, S., Schlessinger, J. 3.2 X-RAY DIFFRACTION 0.278 0.252 False True IGHV3 IGLV1 Lambda None None None None None 3eob H L 0 I protein integrin alpha-l IMMUNE SYSTEM/CELL ADHESION 09/26/08 Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, S., Ding, J. 3.6 X-RAY DIFFRACTION 0.333 0.267 False True IGHV3 IGKV1 Kappa 2.20e-09 -11.8 SPR 25 19258452 4ffw D C 0 B protein dipeptidyl peptidase 4 HYDROLASE/Immune System, INHIBITOR 06/01/12 Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Sudom, A., Walker, N.P., Min, X. 2.9 X-RAY DIFFRACTION 0.311 0.287 False False IGHV1 IGKV4 Kappa None None None None None 5dd6 H L 0 IMMUNE SYSTEM 08/24/15 Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I., Pemble IV, C.W., Haynes, B.F. 1.699 X-RAY DIFFRACTION 0.224 0.191 False True IGHV4 IGKV1 Kappa None None None None None 7mly H I 0 C protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4kxz Q P 0 D protein transforming growth factor beta-2 immune system 05/28/13 crystal structure of tgfb2 in complex with GC2008. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mathieu, M., Moulin, A.G., Wei, R. 2.83 X-RAY DIFFRACTION 0.222 0.183 False True IGHV1 IGKV3 Kappa 3.0000000000000004e-09 -11.627286953008985 SPR TBD 3nid H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION/BLOOD CLOTTING 06/15/10 The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific Antagonist That Does Not Induce Opening HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.3 X-RAY DIFFRACTION 0.215 0.179 False True IGHV14 IGKV14 Kappa None None None None None 6oc8 C NA 0 IMMUNE SYSTEM 03/22/19 Crystal structure of a VHH against the capsid protein from BLV LAMA GLAMA lama glama Carrion, F., Larrieux, N., Trajtenberg, F., Buschiazzo, A. 2.109 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 None None None None None 5jor F E 0 NA NA NA NA IMMUNE SYSTEM 05/02/16 Crystal structure of unbound anti-glycan antibody Fab14.22 at 2.2 A MUS MUSCULUS mus musculus mus musculus Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A. 2.206 X-RAY DIFFRACTION 0.237 0.205 False True IGHV1 IGKV1 Kappa None None None None None 6ug8 H L 0 H carbohydrate GAL polysaccharide IMMUNE SYSTEM 09/26/19 Complex of ch28/11 Fab and SSEA-4 (monoclinic form) MUS MUSCULUS mus musculus mus musculus mus musculus Soliman, C., Ramsland, P.A. 1.89 X-RAY DIFFRACTION 0.230 0.176 False True IGHV2 IGKV4 Kappa None None None None None 5odb A B 0 IMMUNE SYSTEM 07/05/17 Crystal structure of the RA-associated mAb D10 (chimeric Fab fragment) HOMO SAPIENS homo sapiens homo sapiens Dobritzsch, D., Ge, C., Holmdahl, R., Amara, K., Malmstrom, V. 1.53 X-RAY DIFFRACTION 0.214 0.188 False True IGHV3 IGLV3 Lambda None None None None None 3sge J I 0 M peptide r13 peptide IMMUNE SYSTEM 06/14/11 Crystal structure of mAb 17.2 in complex with R13 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Pizarro, J.C., Boulot, G., Hontebeyrie, M., Bentley, G.A. 1.89 X-RAY DIFFRACTION 0.211 0.179 False True IGHV10 IGKV1 Kappa None None None None None 6nf5 G I 0 D protein hiv-1 env bg505 md64 n332-gt5 sosip gp41 VIRAL PROTEIN/immune system 12/18/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Steichen, J.M., Schief, W.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 3i75 B A 0 IMMUNE SYSTEM 07/08/09 Antibody Structure MUS MUSCULUS mus musculus mus musculus Isaacs, N.W., Riboldi-Tunnicliffe, A. 1.95 X-RAY DIFFRACTION 0.213 0.180 False False IGHV1 IGKV19 Kappa None None None None None 7pnq D F 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/07/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 43E6 antibody Fab fragment HOMO SAPIENS; HUMAN CORONAVIRUS OC43 homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 6xbk S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/06/20 Structure of human SMO-G111C/I496C complex with Gi HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Qi, X., Long, T., Li, X. 3.24 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5ovw I NA 0 B protein vitamin b12-binding protein TRANSPORT PROTEIN 08/30/17 Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Mireku, S.A., Sauer, M.M., Glockshuber, R., Locher, K.P. 2.653 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 None None None None None 1sy6 H L 0 A protein t-cell surface glycoprotein cd3 gamma/epsilonchain signaling protein/antibiotic 03/31/04 Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Kjer-Nielsen, L., Dunstone, M.A., Kostenko, L., Ely, L.K., Beddoe, T., Misfud, N.A., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J. 2.1 X-RAY DIFFRACTION 0.255 0.211 False True IGHV1 IGKV4 Kappa 2.73e-06 -7.59 SPR 25 15136729 5xmh H L 0 A protein immunoglobulin gamma-1 heavy chain IMMUNE SYSTEM 05/15/17 Crystal structure of an IgM rheumatoid factor YES8c in complex with IgG1 Fc HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shiroishi, M., Shimokawa, K., Lee, J.M., Kusakabe, M., Ueda, T. 2.8 X-RAY DIFFRACTION 0.272 0.220 False True IGHV1 IGKV3 Kappa 0.00015999999999999999 -5.178506877772148 SPR TBD 5tkj J K 0 L peptide hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 10/06/16 Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.118 X-RAY DIFFRACTION 0.241 0.198 False True IGHV1 IGKV1 Kappa 7.150000000000001e-09 -11.112714836617695 Unknown TBD 12e8 H L 0 NA NA NA NA IMMUNOGLOBULIN 03/14/98 2E8 FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus Rupp, B., Trakhanov, S. 1.9 X-RAY DIFFRACTION 0.271 0.221 False False IGHV14 IGKV6 Kappa None None None None None 4ut6 I M 0 B protein envelope glycoprotein e VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 B7 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 3.2 X-RAY DIFFRACTION 0.2500 0.2120 False True IGHV3 IGLV2 Lambda None None None None None 3etb I i 0 M protein anthrax protective antigen IMMUNE SYSTEM/TOXIN 10/07/08 Crystal structure of the engineered neutralizing antibody M18 complexed with anthrax protective antigen domain 4 MUS MUSCULUS; BACILLUS ANTHRACIS mus musculus bacillus anthracis Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D. 3.8 X-RAY DIFFRACTION 0.276 0.232 True True unknown unknown unknown 3.50e-11 -14.26 SPR 25 19361425 6rlo C D 0 J protein NA cd9 antigen IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop HOMO SAPIENS homo sapiens homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.2 X-RAY DIFFRACTION 0.287 0.254 False True IGHV3 IGKV4 Kappa None None None None None 7jln A B 0 NA NA NA NA IMMUNE SYSTEM 07/30/20 Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M. 2.57 X-RAY DIFFRACTION 0.256 0.197 False True IGHV1 IGKV8 Kappa None None None None None 1xct D C 0 Q | M peptide | protein NA | NA capsid protein c | protein l IMMUNE SYSTEM 09/03/04 Complex HCV core-Fab 19D9D6-Protein L mutant (D55A, L57H, Y64W) in space group P21212 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | finegoldia magna Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 3.05 X-RAY DIFFRACTION 0.329 0.193 False False IGHV9 IGKV8 Kappa None None None None None 4xvt H L 0 G protein envelope glycoprotein gp120 of hiv-1 clade a/e Viral protein/Immune System 01/28/15 Crystal structure of HIV-1 93TH057 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.69 X-RAY DIFFRACTION 0.222 0.181 False True unknown IGKV3 Kappa None None None None None 5m14 C NA 0 A protein maltose-binding periplasmic protein IMMUNE SYSTEM 10/07/16 Synthetic nanobody in complex with MBP ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct escherichia coli k-12 Zimmermann, I., Egloff, P., Seeger, M.A. 1.6 X-RAY DIFFRACTION 0.216 0.190 False True IGHV1 None None None None None 6mb3 H L 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6wrp H L 0 NA NA NA NA IMMUNE SYSTEM 04/29/20 Crystal Structure of PI3-E12 Fab, An Antibody Against Human Parainfluenza Virus Type III HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 2.08 X-RAY DIFFRACTION 0.250 0.196 False True IGHV3 IGKV2 Kappa None None None None None 7pc0 F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 08/03/21 GABA-A receptor bound by a-Cobratoxin LAMA GLAMA; HOMO SAPIENS; NAJA KAOUTHIA lama glama homo sapiens | homo sapiens Kasaragod, V.B., Miller, P.S. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4yhi A B 0 A Hapten 4CC N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine IMMUNE SYSTEM 02/27/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schiele, F., Nar, H. 1.9 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 IGKV1 Kappa None None None None None 1mlb B A 0 IMMUNOGLOBULIN 03/08/95 MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG-WHITE LYSOZYME MUS MUSCULUS mus musculus Braden, B.C., Souchon, H., Eisele, J.-L., Bentley, G.A., Bhat, T.N., Navaza, J., Poljak, R.J. 2.1 X-RAY DIFFRACTION 0.274 unknown False True IGHV1 IGKV5 Kappa None None None None None 2ddq H L 0 L Hapten HRB N-ACETYL-1-[(2R,3S,5R)-5-HYDROXY-2-PENTYLTETRAHYDROFURAN-3-YL]-L-HISTIDINE IMMUNE SYSTEM 02/02/06 Crystal Structure of the Fab fragment of a R310 antibody complexed with (R)-HNE-histidine adduct MUS MUSCULUS mus musculus mus musculus mus musculus Ito, S. 2.35 X-RAY DIFFRACTION 0.263 0.225 False True IGHV1 IGKV1 Kappa None None None None None 7lo7 H L 0 Z protein NA quinolone resistance protein nora TRANSPORT PROTEIN 02/09/21 NorA in complex with Fab25 STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus Brawley, D.N., Sauer, D.B., Song, J.M., Koide, A., Koide, S., Traaseth, N.J., Wang, D.N. 3.74 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6uye G J 0 A protein sgp VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 EBOV GPdMuc Makona bound to rEBOV-548 Fab EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.96 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 2kh2 B b 34 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6z7y B A 0 H | G peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Human insulin in complex with the analytical antibody OXI-005 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.2 X-RAY DIFFRACTION 0.253 0.217 False True IGHV5 IGKV19 Kappa None None None None None 6w7y A B 0 IMMUNE SYSTEM 03/19/20 Crystal structure of SARS-CoV and SARS-CoV-2 reactive human antibody CR3022 HOMO SAPIENS homo sapiens homo sapiens Chen, W.H., Joyce, M.G. 3.3 X-RAY DIFFRACTION 0.278 0.252 False True IGHV5 IGKV4 Kappa None None None None None 5wth E D 0 B protein vp2 VIRUS 12/12/16 Cryo-EM structure for Hepatitis A virus complexed with FAB HEPATOVIRUS A; HEPATITIS A VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis a virus Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z. 4.2 ELECTRON MICROSCOPY False False IGHV5 IGKV4 Kappa None None None None None 7lka C D 0 NA NA NA NA IMMUNE SYSTEM 02/02/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 1.981 X-RAY DIFFRACTION 0.264 0.215 False True IGHV3 IGKV1 Kappa None None None None None 5mhr P O 0 E protein NA viral attachment protein sigma 1 IMMUNE SYSTEM 11/25/16 T3D reovirus sigma1 complexed with 9BG5 Fab fragments REOVIRUS SP.; MUS MUSCULUS mus musculus mus musculus reovirus sp. Stehle, T., Dietrich, M.H. 3.0 X-RAY DIFFRACTION 0.247 0.212 False False IGHV1 IGKV4 Kappa None None None None None 6wir A B 0 C protein NA interleukin-17a CYTOKINE/IMMUNE SYSTEM 04/10/20 Fab antigen complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Antonysamy, S. 2.96 X-RAY DIFFRACTION 0.260 0.217 False True IGHV3 IGKV3 Kappa None None None None None 5drz B A 0 Q peptide envelope glycoprotein gp160 IMMUNE SYSTEM 09/16/15 Crystal structure of anti-HIV-1 antibody F240 Fab in complex with gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 m Gohain, N., Tolbert, W.D., Pazgier, M. 2.54 X-RAY DIFFRACTION 0.259 0.204 False True IGHV3 IGKV4 Kappa 4.4000000000000005e-09 -11.400370293980798 Unknown TBD 3ifp E F 0 S peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 2.95 X-RAY DIFFRACTION 0.269 0.235 False True IGHV8 IGKV1 Kappa 2.45e-08 -10.38 SPR 25 19923222 5usf D NA 0 A protein tyrosyl-trna synthetase, putative ligase/ligase inhibitor 02/13/17 Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor LAMA GLAMA; LEISHMANIA DONOVANI (STRAIN BPK282A1) lama glama leishmania donovani (strain bpk282a1) Barros-Alvarez, X., Hol, W.G.J. 2.75 X-RAY DIFFRACTION 0.244 0.189 False True IGHV3 None None None None None 5bzw B A 0 B carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 06/11/15 Crystal Structure of PCDN-27B, an antibody from the PCDN family of HIV-1 antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Garces, F., WILSON, I.A. 2.9 X-RAY DIFFRACTION 0.297 0.233 False True IGHV4 IGKV3 Kappa None None None None None 5myk B A 0 C peptide amyloid beta a4 protein IMMUNE SYSTEM 01/26/17 Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Parthier, C., Piechotta, A., Stubbs, M.T. 1.6 X-RAY DIFFRACTION 0.210 0.173 False True IGHV5 IGKV1 Kappa 9.9e-10 -12.284151464664008 Unknown TBD 3whe O P 0 B protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 5i1l H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV5-51/IGKV4-1 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 1.95 X-RAY DIFFRACTION 0.258 0.194 False True IGHV5 IGKV4 Kappa None None None None None 2aju H L 0 IMMUNE SYSTEM 08/02/05 Cyrstal structure of cocaine catalytic antibody 7A1 Fab' MUS MUSCULUS mus musculus mus musculus Zhu, X., Wilson, I.A. 1.5 X-RAY DIFFRACTION 0.228 0.181 False False IGHV3 IGKV2 Kappa None None None None None 5mhs H F 0 NA NA NA NA IMMUNE SYSTEM 11/25/16 T1L reovirus sigma1 complexed with 5C6 Fab fragments REOVIRUS TYPE 1 (STRAIN LANG); MUS MUSCULUS mus musculus mus musculus Stehle, T., Dietrich, M.H. 3.7 X-RAY DIFFRACTION 0.278 0.261 False False IGHV2 IGKV3 Kappa None None None None None 2ntf H L 0 H Hapten OHM 3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE IMMUNE SYSTEM 11/07/06 Crystal Structure of a Quorum-Quenching Antibody in Complex with an N-Acyl-L-Homoserine Lactone Analog MUS MUSCULUS mus musculus mus musculus mus musculus Debler, E.W., Wilson, I.A. 3.18 X-RAY DIFFRACTION 0.265 0.210 False False IGHV1 IGLV1 Lambda 3.00e-07 -9.25 Other 37 17400249 4xgz C D 0 c peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 4ky1 H L 0 IMMUNE SYSTEM 05/28/13 humanized HP1/2 Fab HOMO SAPIENS homo sapiens homo sapiens Arndt, J.W., Hanf, K.J.M., Lugovskoy, A., Chen, L.L., Jarpe, M., Boriack-Sjodin, A., Li, Y., van Vlijmen, H., Pepinsky, B., Taylor, F., Silvian, L., Taveras, A. 2.97 X-RAY DIFFRACTION 0.284 0.206 False True IGHV1 IGKV4 Kappa None None None None None 4xcn E F 0 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA); 2.9 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.246 0.193 False True IGHV1 IGKV3 Kappa None None None None None 4rau B A 0 C protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 7ew5 Q R 0 b protein NA unknown VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 4buh A a 0 06/20/13 Human IgE against the major allergen Bet v 1 - Crystal structure of clone M0418 scFv HOMO SAPIENS homo sapiens Davies, A.M., Levin, M., Lilljekvist, M., Carlsson, F., Gould, H.J., Sutton, B.J., Ohlin, M. 1.3 X-RAY DIFFRACTION 0.1728 0.1453 True True unknown unknown unknown None None None None None 7mzk H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 96 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.25 X-RAY DIFFRACTION 0.235 0.197 False True IGHV1 IGKV4 Kappa None None None None None 7eo4 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/21/21 Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to BAF312 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens He, Y., Xu, Z., Ikuta, T., Inoue, A. 2.86 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7oh1 E D 0 A protein NA tetanus toxin TOXIN 05/07/21 Tetanus neurotoxin LC-HN domain in complex with TT110-Fab1 CLOSTRIDIUM TETANI; HOMO SAPIENS homo sapiens homo sapiens clostridium tetani Grinzato, A., Kandiah, E., Zanotti, G. 8 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7zwf B b 0 A protein NA gametocyte surface protein p45/48 CELL ADHESION 05/19/22 Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 Mus musculus; Plasmodium falciparum mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 2.132 X-RAY DIFFRACTION 0.286 0.276 True True unknown unknown unknown None None None None None 7qbg E NA 0 C | B protein | protein NA | NA transcobalamin-2 | cd320 antigen TRANSPORT PROTEIN 11/19/21 TC:CD320 in complex with nanobody TC-Nb4 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens | homo sapiens Bloch, J.S., Locher, K.P. 2.69 X-RAY DIFFRACTION 0.285 0.227 False True IGHV1 NA NA None None None None None 6m38 H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 03/02/20 X-ray structure of a Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) in S-duloxetine bound form DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Shabareesh, P., Mallela, A.K., Joseph, D., Penmatsa, A. 3.001 X-RAY DIFFRACTION 0.244 0.215 False True IGHV5 IGKV4 Kappa None None None None None 7czx I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B9 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV4 Kappa None None None None None 7vux H L 0 A protein NA programmed cell death protein 1 IMMUNE SYSTEM 11/04/21 Complex structure of PD1 and 609A-Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Huang, H., Zhu, Z., Zhao, J., Jiang, L., Yang, H., Deng, L., Meng, X., Ding, J., Yang, S., Zhao, L., Xu, W., Wang, X. 1.64 X-RAY DIFFRACTION 0.202 0.160 False True IGHV5 IGKV3 Kappa None None None None None 6x1v H L 0 D peptide NA aclyana-3-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC44-8) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R., Wilson, I.A., Hunter, T. 2.11 X-RAY DIFFRACTION 0.220 0.177 False True IGHV1 IGKV1 Kappa None None None None None 4n1e NA A 0 I protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 2h2p E F 0 B protein clc cl transporter ION TRANSPORT 05/19/06 Crystal structure of CLC-ec1 in complex with Fab fragment in SeCN- ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Nguitragool, W., Miller, C. 3.1 X-RAY DIFFRACTION 0.280 0.278 False False IGHV4 IGKV4 Kappa None None None None None 3ra7 H L 0 L Hapten DOG DIGOXIGENIN IMMUNE SYSTEM 03/27/11 Bispecific digoxigenin binding antibodies for targeted payload delivery MUS MUSCULUS mus musculus mus musculus mus musculus Hopfner, K.P., Lammens, A. 2.798 X-RAY DIFFRACTION 0.231 0.204 False True IGHV5 IGKV10 Kappa None None None None None 6med G I 0 IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 2.04 X-RAY DIFFRACTION 0.216 0.182 False True IGHV1 IGKV1 Kappa None None None None None 7njz H L 0 C peptide NA region from c-c chemokine receptor type 5 n-terminaldomain IMMUNE SYSTEM 02/17/21 X-ray crystallography study of RoAb13 which binds to PIYDIN, a part of the CCR5 N terminal domain MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Helliwell, J.R., Chayen, N., Saridakis, E., Govada, L. 3.2 X-RAY DIFFRACTION 0.292 0.269 False False IGHV5 IGKV8 Kappa None None None None None 7rbt E e 0 A protein NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short MEMBRANE PROTEIN 07/06/21 cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT mus musculus homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.08 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5cws H G 0 K | I | J | L protein | protein | protein | peptide NA | NA | NA | NA nucleoporin nup57 | nucleoporin nsp1 | nucleoporin nup49 | nucleoporin nic96 PROTEIN TRANSPORT 07/28/15 Crystal structure of the intact Chaetomium thermophilum Nsp1-Nup49-Nup57 channel nucleoporin heterotrimer bound to its Nic96 nuclear pore complex attachment site HOMO SAPIENS; CHAETOMIUM THERMOPHILUM (STRAIN DSM 1495 / CBS 144.50 / IMI 039719); CHAETOMIUM THERMOPHILUM homo sapiens homo sapiens chaetomium thermophilum (strain dsm 1495 / cbs144.50 / imi 039719) | chaetomium thermophilum (strain dsm 1495 / cbs144.50 / imi 039719) | chaetomium thermophilum | chaetomium thermophilum (strain dsm 1495 / cbs144.50 / imi 039719) Bley, C.J., Petrovic, S., Paduch, M., Lu, V., Kossiakoff, A.A., Hoelz, A. 3.77 X-RAY DIFFRACTION 0.265 0.229 False True IGHV3 IGKV1 Kappa None None None None None 6wo5 C D 0 F protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/24/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody 212.1.1 and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 2.619 X-RAY DIFFRACTION 0.250 0.203 False True IGHV1 IGKV2 Kappa None None None None None 6bf4 B C 0 A protein hiv-1 clade ae gp120 core viral protein/immune system 10/25/17 Crystal Structure of HIV-1 Clade AE Strain CNE55 gp120 Core in Complex with Neutralizing Antibody VRC-PG05 that Targets the Center of the Silent Face on the Outer Domain of gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.382 X-RAY DIFFRACTION 0.228 0.192 False True IGHV3 IGKV4 Kappa 1.78e-07 -9.20807461785177 SPR TBD 7k43 C D 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/14/20 SARS-CoV-2 spike in complex with the S2M11 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4f15 K L 0 J protein hemagglutinin IMMUNE SYSTEM 05/06/12 Molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Lee, J.H., Park, Y.H., Khan, T.G., Lee, J.Y., Kang, S.H., Alam, I. 2.81 X-RAY DIFFRACTION 0.289 0.233 False False IGHV3 IGKV7 Kappa None None None None None 4dn4 H L 0 M protein c-c motif chemokine 2 IMMUNE SYSTEM 02/08/12 Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Obmolova, G., Teplyakov, A., Malia, T., Grygiel, T., Sweet, R., Snyder L., Gilliland, G. 2.8 X-RAY DIFFRACTION 0.266 0.196 False True IGHV1 IGKV3 Kappa 3.8e-11 -14.215718638691294 Unknown TBD 1kxt B NA 0 A protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 2.0 X-RAY DIFFRACTION 0.236 0.203 False True IGHV1 2.35e-07 -9.04 SPR 11960990 4fqr w x 0 W protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 5ip4 A NA 0 E protein neuronal migration protein doublecortin TRANSFERASE 03/09/16 X-RAY STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Ruf, A., Benz, J., Burger, D., D'Arcy, B., Debulpaep, M., Di Lello, P., Fry, D., Huber, W., Kremer, T., Laeremans, T., Matile, H., Ross, A., Rudolph, M.G., Rufer, A.C., Sharma, A., Steinmetz, M.O., Steyaert, J., Schoch, G., Stihle, M., Thoma, R. 1.81 X-RAY DIFFRACTION 0.246 0.194 False True IGHV1 4.51e-07 -8.657252145183932 SPR TBD 7ps0 H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with beta-24 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.92 X-RAY DIFFRACTION 0.271 0.222 False True IGHV4 IGLV2 Lambda None None None None None 7ly9 B C 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/06/21 Cryo-EM structure of 2909 Fab in complex with 3BNC117 Fab and CAP256.wk34.c80 SOSIP.RnS2 N160K HIV-1 Env trimer HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.91 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7lsi A C 0 NA NA NA NA ANTITUMOR PROTEIN,IMMUNE SYSTEM 02/18/21 Structure of KD035, a VEGFR2 monoclonal antibody HOMO SAPIENS homo sapiens homo sapiens Depetris, R.S. 2.4 X-RAY DIFFRACTION 0.274 0.197 False True IGHV3 IGLV3 Lambda None None None None None 5h30 I M 0 C protein structural protein e VIRUS/IMMUNE SYSTEM 10/19/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lok, S.-M. 4.4 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 5f93 H NA 0 G protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.99 X-RAY DIFFRACTION 0.234 0.181 False True IGHV1 None None None None None 1ieh A NA 5 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 6cf2 A B 0 F | G protein | nucleic-acid NA | NA protein rev | rna (35-mer) RNA BINDING PROTEIN/RNA 02/13/18 Crystal structure of HIV-1 Rev (residues 1-93)-RNA aptamer complex ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 | synthetic construct Eren, E., Dearborn, A.D., Wingfield, P.T. 3.0 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 IGKV1 Kappa None None None None None 3upc E NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 6gkd G NA 0 F protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 5k8a V M 0 IMMUNE SYSTEM 05/27/16 NIST FAB MUS MUSCULUS mus musculus mus musculus Gallagher, D.T., Galvin, C.V., Karageorgos, I., Marino, J.P. 1.999 X-RAY DIFFRACTION 0.189 0.164 False True IGHV2 IGKV1 Kappa None None None None None 6x9r H L 0 A | B protein | protein NA | NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 | hiv-1 envelope glycoprotein bg505 sosip.664 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 06/03/20 HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in HEK293F cells in complex with RM20A3 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 2zcl H L 0 P protein prostate-specific antigen IMMUNE SYSTEM 11/09/07 Crystal structure of human prostate specific antigen complexed with an activating antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Menez, R., Stura, E., Jolivet-Reynaud, C. 3.25 X-RAY DIFFRACTION 0.251 0.201 False False IGHV1 IGKV3 Kappa None None None None None 6nc2 P U 0 J | D protein | protein NA | NA amc011 v4.2 sosip gp41 | amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B. 5.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5toj F NA 0 C protein fusion glycoprotein f0, fibritin chimera VIRAL PROTEIN/IMMUNE SYSTEM 10/17/16 Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4 HUMAN RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama human respiratory syncytial virus Gilman, M.S.A., Kabeche, S.C., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.234 0.184 False True IGHV1 2.3e-08 -10.420467653019871 SPR TBD 6o3c B NA 0 A protein smoothened homolog SIGNALING PROTEIN 02/26/19 Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 MUS MUSCULUS; SYNTHETIC CONSTRUCT lama glama mus musculus Deshpande, I.S., Liang, J., Hedeen, D., Roberts, K.J., Zhang, Y., Ha, B., Latorraca, N.R., Faust, B., Dror, R.O., Beachy, P.A., Myers, B.R., Manglik, A. 2.8 X-RAY DIFFRACTION 0.294 0.245 False True IGHV1 None None None None None 7n9v B NA 0 C protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/21 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Tripler, T.N. 3.45 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 NA NA None None None None None 4yhp H L 0 P peptide h3k9me3 peptide IMMUNE SYSTEM 02/27/15 Crystal structure of 309M3-B Fab in complex with H3K9me3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Hattori, T., Dementieva, I.S., Montano, S.P., Koide, S. 2.53 X-RAY DIFFRACTION 0.250 0.211 False True IGHV3 IGLV3 Lambda 2e-09 -11.867518412372508 Unknown TBD 7lex R P 0 J protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7ooi A NA 0 NA NA NA NA IMMUNE SYSTEM 05/27/21 Anti-EphA1 JD1 VH domain HOMO SAPIENS homo sapiens Ereno-Orbea, J., Nilvebrant, J., Sidhu, S., Julien, J.P. 2.28 X-RAY DIFFRACTION 0.297 0.269 False True IGHV3 NA NA None None None None None 6k2i A NA 18 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7jkt H L 0 G protein NA hiv-1 gp120 core from strain d45-01dg5 Viral Protein/Immune System 07/28/20 Crystal structure of vaccine-elicited broadly neutralizing VRC01-class antibody 2413a in complex with HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Zhou, T., Chen, X., Kwong, P.D., Mascola, J.R. 2.75 X-RAY DIFFRACTION 0.252 0.197 False True IGHV1 IGKV3 Kappa None None None None None 6hgu H L 0 IMMUNE SYSTEM 08/23/18 Crystal Structure of an anti-APP-tag Fab MUS MUSCULUS mus musculus mus musculus Rondeau, J.M., Goepfert, A. 1.5 X-RAY DIFFRACTION 0.207 0.187 False True IGHV8 IGKV1 Kappa None None None None None 1xf3 B A 0 IMMUNE SYSTEM 09/13/04 Structure of ligand-free Fab DNA-1 in space group P65 MUS MUSCULUS mus musculus mus musculus Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J. 2.3 X-RAY DIFFRACTION 0.243 0.208 False True IGHV1 IGKV12 Kappa None None None None None 3chn C O 8 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 5ebl A B 0 C protein ph-gated potassium channel kcsa MEMBRANE PROTEIN 10/19/15 KcsA T75G in the Conductive State MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Matulef, K., Valiyaveetil, F.I. 2.3 X-RAY DIFFRACTION 0.242 0.205 False True IGHV1 IGKV5 Kappa None None None None None 4mqx E F 0 B protein h(+)/cl(-) exchange transporter clca metal transport, membrane protein 09/16/13 CLC-ec1 Fab Complex Cysless A399C-A432C mutant ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Basilio, D., Noack, K., Picollo, A., Accardi, A. 3.516 X-RAY DIFFRACTION 0.258 0.223 False True IGHV4 IGKV4 Kappa None None None None None 4aiz NA A 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of 3mJL2 from the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.75 X-RAY DIFFRACTION 0.2185 0.1662 False True IGLV3 Lambda None None None None None 5dqj H L 0 IMMUNE SYSTEM 09/14/15 Structure of unliganded S55-5 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.61 X-RAY DIFFRACTION 0.228 0.193 False False IGHV5 IGKV3 Kappa None None None None None 7cfn N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/27/20 Cryo-EM structure of the INT-777-bound GPBAR-Gs complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Yang, F., Mao, C., Guo, L., Lin, J., Ming, Q., Xiao, P., Wu, X., Shen, Q., Guo, S., Shen, D., Lu, R., Zhang, L., Huang, S., Ping, Y., Zhang, C., Ma, C., Zhang, K., Liang, X., Shen, Y., Nan, F., Yi, F., Luca, V., Zhou, J., Jiang, C., Sun, J., Xie, X., Yu, X., Zhang, Y. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7eh3 A NA 3 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 1ub6 H L 0 IMMUNE SYSTEM 03/30/03 Crystal structure of Antibody 19G2 with sera ligand MUS MUSCULUS mus musculus mus musculus Beuscher, A.B., Wirsching, P., Lerner, R.A., Janda, K., Stevens, R.C. 2.12 X-RAY DIFFRACTION 0.292 0.264 False True IGHV5 IGKV2 Kappa None None None None None 6nex B A 0 IMMUNE SYSTEM 12/18/18 Fab fragement of anti-cocaine antibody h2E2 MUS MUSCULUS mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.15 X-RAY DIFFRACTION 0.254 0.214 False True IGHV3 IGLV2 Lambda None None None None None 3x3g H L 0 IMMUNE SYSTEM 01/20/15 Fab fragment from anti TRAIL-R2 Human Agonist Antibody KMTR2 HOMO SAPIENS homo sapiens homo sapiens Tamada, T. 2.51 X-RAY DIFFRACTION 0.224 0.186 False True IGHV1 IGKV3 Kappa None None None None None 3bd5 NA A 0 IMMUNE SYSTEM 11/14/07 Crystal structure of single domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals MUS MUSCULUS mus musculus Park, S.K., Kim, J.S. 2.0 X-RAY DIFFRACTION 0.276 0.224 True True IGKV8 Kappa None None None None None 7xod X Y 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/01/22 SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xu, Y., Wu, C., Liu, H., Yin, W., Xu, H.E. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5csz H L 0 D peptide amyloid beta a4 protein IMMUNE SYSTEM 07/23/15 CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Benz, J., Burger, D., Loetscher, H.R., Bohrmann, B. 1.8 X-RAY DIFFRACTION 0.230 0.196 False True IGHV3 IGKV3 Kappa 1.7e-08 -10.599564136380756 Unknown TBD 7amr H L 0 B protein NA human t-cell receptor beta chain trbc2 IMMUNE SYSTEM 10/09/20 Crystal structure of the complex of the KFN mutant of Jovi-1 Fab with human TRBC1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferrari, M., Bulek, A., Bughda, R., Jha, R., Welin, M., Logan, D.T., Sewell, A., Onuoha, S., Pule, M. 1.949 X-RAY DIFFRACTION 0.225 0.179 False True IGHV1 IGKV1 Kappa None None None None None 7aqx C NA 0 A protein NA variant surface glycoprotein mitat 1.2 MEMBRANE PROTEIN 10/23/20 Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB9) LAMA GLAMA; TRYPANOSOMA BRUCEI BRUCEI lama glama trypanosoma brucei brucei Stebbins, C.E., Hempelmann, A. 1.499 X-RAY DIFFRACTION 0.192 0.164 False True IGHV1 NA NA None None None None None 6ur5 A B 0 C protein influenza hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/10/20 Resurfaced influenza hemagglutinin in complex with a broadly neutralizing antibody HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Bajic, G., Schmidt, A.G. 4.0 X-RAY DIFFRACTION 0.322 0.300 False True IGHV1 IGLV2 Lambda None None None None None 3u46 A B 0 IMMUNE SYSTEM 10/07/11 CH04H/CH02L P212121 HOMO SAPIENS homo sapiens homo sapiens Louder, R., Pancera, M., McLellan, J.S., Kwong, P.D. 2.906 X-RAY DIFFRACTION 0.245 0.215 False True IGHV3 IGKV3 Kappa None None None None None 6ucf H L 0 A peptide hiv fusion peptide IMMUNE SYSTEM/VIRAL PROTEIN 09/16/19 N123-VRC34_pI4 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Kwong, P.D. 1.29 X-RAY DIFFRACTION 0.182 0.167 False True IGHV1 IGKV1 Kappa None None None None None 5ebw A B 0 C protein ph-gated potassium channel kcsa MEMBRANE PROTEIN 10/19/15 KcsA with G77ester mutation MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Matulef, K., Valiyaveetil, F.I. 2.3 X-RAY DIFFRACTION 0.249 0.222 False True IGHV1 IGKV5 Kappa None None None None None 1ad9 B A 0 IMMUNOGLOBULIN 02/24/97 IGG-FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY CTM01 HOMO SAPIENS homo sapiens homo sapiens Banfield, M.J., Brady, R.L. 2.8 X-RAY DIFFRACTION 0.284 0.233 False True IGHV1 IGKV1 Kappa None None None None None 1gpo I M 0 IMMUNOGLOBULIN 03/27/97 CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT MUS MUSCULUS synthetic construct mus musculus Schiweck, W., Skerra, A. 1.95 X-RAY DIFFRACTION 0.283 0.214 False True IGHV4 IGKV6D Kappa None None None None None 7c88 A B 0 C protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 05/29/20 Complex structure of JS003 and PD-L1 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Bi, X., Shi, R., Chai, Y., Qi, J., Yan, J., Tan, S. 1.997 X-RAY DIFFRACTION 0.258 0.222 False True IGHV4 IGKV4 Kappa None None None None None 4lkx A B 0 R peptide cemx segment IMMUNE SYSTEM 07/09/13 Humanized antibody 4B12 Fab complexed with a CemX segment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chu, H.M., Wright, J., Chan, Y.H., Lin, C.J., Chang, T.W., Lim, C. 1.92 X-RAY DIFFRACTION 0.229 0.180 False True IGHV4 IGKV1 Kappa None None None None None 4xcy C D 0 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidylglycerol (06:0 PG) HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 3.96 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 IGKV3 Kappa None None None None None 6njn I i 0 A protein glutamate receptor 1 MEMBRANE PROTEIN 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.5 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 4mhj K J 0 G protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 6.98 X-RAY DIFFRACTION 0.387 0.377 False True IGHV1 IGKV3 Kappa 1e-09 -12.27819680469229 BLI TBD 2kh2 B b 54 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 4aj0 NA C 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rCW, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.7 X-RAY DIFFRACTION 0.2116 0.1741 False True IGLV3 Lambda None None None None None 2qtj A L 3 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6db5 H L 0 P peptide hiv-1 gp120 v3 peptide from ny5 strain IMMUNE SYSTEM 05/02/18 Crystal structure of anti-HIV-1 V3 Fab TA6 in complex with a HIV-1 gp120 V3 peptide from NY5 strain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.-P. 2.599 X-RAY DIFFRACTION 0.283 0.227 False True IGHV1 IGLV3 Lambda None None None None None 6azl B A 0 IMMUNE SYSTEM 09/11/17 Structure of cetuximab with aminoheptanoic acid-linked N-carboxyethylarginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.482 X-RAY DIFFRACTION 0.216 0.170 False True IGHV2 IGKV5 Kappa 1.18e-05 -6.723155843448945 Unknown TBD 7nx7 H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the K417N mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.3 X-RAY DIFFRACTION 0.239 0.208 False True IGHV3 IGKV1 Kappa None None None None None 7eh3 A NA 2 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 1mci NA A 0 P peptide peptide n-acetyl-d-phe-l-his-d-pro-oh IMMUNE SYSTEM 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown 0.177 False True IGLV2 Lambda None None None None None 4f9l d D 0 A protein butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 05/18/12 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 20.1 Single Chain Antibody HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Palakodeti, A., Sandstrom, A., Sundaresan, L., Harly, C., Nedellec, S., Olive, D., Scotet, E., Bonneville, M., Adams, E.J. 3.1404 X-RAY DIFFRACTION 0.303 0.254 True True unknown unknown unknown 6.600000000000001e-08 -9.795894745207022 SPR TBD 6qf6 D d 0 APOPTOSIS 01/09/19 Structure of an E.coli expressed anti-Mcl1 scFv HOMO SAPIENS homo sapiens Luptak, J. 2.59 X-RAY DIFFRACTION 0.262 0.181 True True unknown unknown unknown None None None None None 1mel A NA 0 L protein NA lysozyme COMPLEX (ANTIBODY/ANTIGEN) 06/06/96 CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Desmyter, A., Transue, T.R., Arbabi Gharoudi, M., Dao Thi, M., Poortmans, F., Hamers, R., Muyldermans, S., Wyns, L. 2.5 X-RAY DIFFRACTION 0.323 0.221 False True IGHV1 NA NA None None None None None 4p2c H NA 0 C protein NA shiga toxin 2e, subunit b TOXIN 03/03/14 Complex of Shiga toxin 2e with a neutralizing single-domain antibody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Lo, A.W.H., Moonens, K., De Kerpel, M., Brys, L., Pardon, E., Remaut, H., De Greve, H. 2.818 X-RAY DIFFRACTION 0.253 0.187 False True IGHV1 NA NA None None None None None 5tqa H L 0 IMMUNE SYSTEM 10/23/16 Crystal Structure of DH270.6 (unliganded) from the DH270 Broadly Neutralizing N332-Glycan Dependent Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.723 X-RAY DIFFRACTION 0.201 0.185 False True IGHV1 IGLV2 Lambda None None None None None 2bse F NA 0 C protein receptor binding protein RECEPTOR 05/20/05 Structure of Lactococcal Bacteriophage p2 Receptor Binding Protein in complex with a llama VHH domain LACTOCOCCUS LACTIS PHAGE P2; LAMA GLAMA lama glama lactococcus lactis phage p2 Spinelli1, S., Desmyter, A., Verrips, C.T., deHaard, H.J.W., Moineau, S., Cambillau, C. 2.7 X-RAY DIFFRACTION 0.294 0.251 False True IGHV1 None None None None None 7m8l N Q 0 E protein NA virion spike glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/30/21 EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7lk4 F E 0 P protein NA bcl-2 homologous antagonist/killer APOPTOSIS 02/01/21 Crystal structure of BAK L100A in complex with activating antibody fragments HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Robin, Y.A., Colman, P.M. 3.1 X-RAY DIFFRACTION 0.262 0.214 False True IGHV5 IGKV16 Kappa None None None None None 7r24 E NA 0 A protein NA activity-regulated cytoskeleton-associated protein STRUCTURAL PROTEIN 02/04/22 Crystal structure of rat Arc CTD in complex with two anti-Arc nanobodies RATTUS NORVEGICUS; VICUGNA PACOS vicugna pacos rattus norvegicus Markusson, S., Kursula, P. 2.7 X-RAY DIFFRACTION 0.274 0.257 False True IGHV1 NA NA None None None None None 1rhh B A 0 IMMUNE SYSTEM 11/14/03 Crystal Structure of the Broadly HIV-1 Neutralizing Fab X5 at 1.90 Angstrom Resolution HOMO SAPIENS homo sapiens homo sapiens Darbha, R., Phogat, S., Labrijn, A.F., Shu, Y., Gu, Y., Andrykovitch, M., Zhang, M.Y., Pantophlet, R., Martin, L., Vita, C., Burton, D.R., Dimitrov, D.S., Ji, X. 1.9 X-RAY DIFFRACTION 0.227 0.224 False True IGHV1 IGKV3 Kappa None None None None None 3j8w F J 0 D protein NA l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 13 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV12 Kappa None None None None None 5u7o H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 12/12/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer bound to small molecule HIV-1 entry inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 A HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Lai, Y.-T., Kwong, P.D. 3.031 X-RAY DIFFRACTION 0.325 0.272 False True IGHV4 IGLV3 Lambda 7.3e-08 -9.736169606109948 Unknown TBD 7mhx A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 04/15/21 KcsA E71V closed gate with Ba2+ MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Rohaim, A., Li, J., Weingarth, M., Roux, B. 2.85 X-RAY DIFFRACTION 0.244 0.202 False True IGHV1 IGKV5 Kappa None None None None None 5uk4 r NA 0 R protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 3v6f H L 0 IMMUNE SYSTEM 12/19/11 Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound MUS MUSCULUS mus musculus mus musculus Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. 2.52 X-RAY DIFFRACTION 0.220 0.179 False False IGHV5 IGKV8 Kappa None None None None None 6ev1 C D 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Dubel, S., Blankenfeldt, W., Rau, U. 3.043 X-RAY DIFFRACTION 0.238 0.186 False True IGHV1 IGKV4 Kappa None None None None None 2gjj a A 0 IMMUNE SYSTEM 03/31/06 Crystal structure of a single chain antibody scA21 against Her2/ErbB2 MUS MUSCULUS mus musculus Zhu, Z. 2.1 X-RAY DIFFRACTION 0.226 0.189 True True unknown unknown unknown None None None None None 6dzm J L 0 F | C protein | protein NA | NA bundibugyo virus gp2 | bundibugyo virus gp1 VIRAL PROTEIN 07/05/18 Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus | bundibugyo ebolavirus Murin, C.D., Ward, A.B. 4.29 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 5mp6 H L 0 IMMUNE SYSTEM 12/15/16 Structure of the Unliganded Fab from HIV-1 Neutralizing Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface, at two Angstrom resolution. HOMO SAPIENS homo sapiens homo sapiens Wibmer, C.K., Gorman, J., Kwong, P.D. 1.959 X-RAY DIFFRACTION 0.240 0.198 False True IGHV4 IGLV2 Lambda None None None None None 3uc0 I M 0 B protein envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 10/25/11 Crystal structure of domain I of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 DENGUE VIRUS 4; PAN TROGLODYTES pan troglodytes pan troglodytes dengue virus 4 Cockburn, J.J.B., Stura, E.A., Navarro-Sanchez, M.E., Rey, F.A. 2.71 X-RAY DIFFRACTION 0.252 0.220 False True IGHV4 IGKV1 Kappa 1.30e-09 -12.6 Other 37 22139356 6um7 J K 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of vaccine-elicited HIV-1 neutralizing antibody DH270.mu1 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunders, K., Haynes, B.F. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 1u8p B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ECDKWCS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 3.23 X-RAY DIFFRACTION 0.222 0.212 False False IGHV2 IGKV1 Kappa None None None None None 3oau H L 0 H carbohydrate MAN polysaccharide IMMUNE SYSTEM 08/05/10 Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Non-Domain-Exchanged Forms, but only binds the HIV-1 Glycan Shield if Domain-Exchanged HOMO SAPIENS homo sapiens homo sapiens homo sapiens Doores, K.J., Fulton, Z., Huber, M., Wilson, I.A., Burton, D.R. 1.9 X-RAY DIFFRACTION 0.243 0.212 False True IGHV3 IGKV1 Kappa None None None None None 5xp1 NA E 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 7zfa M N 0 D protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV4 IGKV1 Kappa None None None None None 5c0s H L 0 A protein hemagglutinin, envelope glycoprotein, fibritin fusionprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/12/15 Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the broadly neutralizing antibody CR6261 HOMO SAPIENS; INFLUENZA A VIRUS, HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 GROUP M SUBTYPE B, ENTEROBACTERIA PHAGE T4 homo sapiens homo sapiens influenza a virus, human immunodeficiency virustype 1 group m subtype b, enterobacteria phage t4 Boyington, J.C., Kwong, P.D., Nabel, G.J., Mascola, J.R. 4.3 X-RAY DIFFRACTION 0.310 0.238 False True IGHV1 IGLV1 Lambda 7.700000000000001e-09 -11.06880707255872 SPR TBD 4unt NA F 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 4i13 B NA 0 A protein dihydrofolate reductase OXIDOREDUCTASE/IMMUNE SYSTEM 11/19/12 Nanobody ca1697 binding to the DHFR.folate binary complex LAMA GLAMA; ESCHERICHIA COLI lama glama escherichia coli Oyen, D., Steyaert, J., Barlow, J.N. 1.6 X-RAY DIFFRACTION 0.180 0.154 False True IGHV1 None None None None None 3iu3 A B 0 K protein interleukin-2 receptor alpha chain IMMUNE SYSTEM 08/29/09 Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Du, J., Yang, H., Wang, J., Ding, J. 2.9 X-RAY DIFFRACTION 0.262 0.215 False True IGHV1 IGKV4 Kappa 1.40e-10 -13.44 SPR 25 20032294 1kxq G NA 0 B protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 1.6 X-RAY DIFFRACTION 0.219 0.197 False True IGHV1 3.50e-09 -11.53 SPR 11960990 4p3c H L 0 M peptide matrix metalloproteinase-14 IMMUNE SYSTEM 03/06/14 MT1-MMP:Fab complex (Form I) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Rozenberg, H., Udi, Y., Sagi, I. 1.943 X-RAY DIFFRACTION 0.200 0.153 False True IGHV5 IGKV1 Kappa None None None None None 4khx H L 0 A protein gp41 helix Immune system 05/01/13 Crystal structure of gp41 helix complexed with antibody 8062 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Li, M., Gustchina, A,, Wlodawer, A. 2.921 X-RAY DIFFRACTION 0.289 0.237 False False IGHV1 IGLV3 Lambda 4.2e-09 -11.427932644037817 ITC TBD 1ghf H L 0 ANTIBODY FAB FRAGMENT 11/30/95 ANTI-ANTI-IDIOTYPE GH1002 FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus Ban, N., Day, J., Wang, X., Ferrone, S., McPherson, A. 2.7 X-RAY DIFFRACTION unknown 0.210 False False IGHV9 IGKV10 Kappa None None None None None 6obe B NA 0 A protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V6H8 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.732 X-RAY DIFFRACTION 0.208 0.171 False True IGHV1 None None None None None 5npi A a 0 D peptide epitope peptide VIRAL PROTEIN 04/16/17 Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus hepatitis c virus Vasiliauskaite, I., Rey, F.A., Krey, T. 2.0 X-RAY DIFFRACTION 0.217 0.197 True True unknown unknown unknown None None None None None 7mdu H L 0 A protein NA surface protein gp120 VIRAL PROTEIN 04/06/21 BG505 SOSIP MD39 in complex with the monoclonal antibodies Rh.33104 mAb.1 and RM20A3 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta human immunodeficiency virus 1 Antanasijevic, A., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5vjq C D 0 J protein lysozyme HYDROLASE/IMMUNE SYSTEM 04/19/17 Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I) MUS MUSCULUS; ANAS PLATYRHYNCHOS mus musculus mus musculus anas platyrhynchos Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.235 0.193 False True IGHV3 IGKV5 Kappa None None None None None 7ej4 J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 04/01/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-25 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 7dk2 D E 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/22/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M., Chen, S. 3.0 X-RAY DIFFRACTION 0.304 0.258 False True IGHV3 IGKV1 Kappa None None None None None 6ws6 E F 0 IMMUNE SYSTEM 05/27/20 Structural and functional analysis of a potent sarbecovirus neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., Marco, A.D., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Telenti, A., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 IGKV3 Kappa None None None None None 4xbg J K 0 IMMUNE SYSTEM 12/16/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA): 2.73 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGKV3 Kappa None None None None None 6oq5 F NA 0 A protein toxin b TOXIN 04/25/19 Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs CLOSTRIDIOIDES DIFFICILE; CAMELIDAE camelidae clostridioides difficile Chen, P., Lam, K., Jin, R. 3.87 X-RAY DIFFRACTION 0.315 0.263 False True IGHV1 None None None None None 7pg8 I G 0 K protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 6cde m n 0 c protein unknown VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False False IGHV4 unknown unknown None None None None None 3j5m H G 0 E protein bg505 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/13 Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lyumkis, D., Julien, J.-P., Wilson, I.A., Ward, A.B. 5.8 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6wty H I 0 G protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 253245 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.481 X-RAY DIFFRACTION 0.301 0.262 False True IGHV1 IGLV2 Lambda None None None None None 6zdg B C 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/14/20 Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4rau K J 0 L protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 7nd7 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 3oay H L 0 H Hapten BDF BETA-D-FRUCTOPYRANOSE IMMUNE SYSTEM 08/05/10 A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity HOMO SAPIENS homo sapiens homo sapiens homo sapiens Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G 1.95 X-RAY DIFFRACTION 0.223 0.182 False True IGHV3 IGKV1 Kappa None None None None None 7cws P M 0 R protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike Proteins Trimer in Complex with FC05 and H014 Fabs Cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L., Wang, X. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7mtb H L 0 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1ngw B A 0 B Hapten MMP N-METHYLMESOPORPHYRIN IMMUNE SYSTEM 12/18/02 Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Yin, J., Andryski, S.E., Beuscher IV, A.E., Stevens, R.C., Schultz, P.G. 2.6 X-RAY DIFFRACTION 0.318 0.275 False True IGHV1 IGKV6 Kappa 2.07e-08 -10.48 SPR 12552112 4m5z H L 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/08/13 Crystal structure of broadly neutralizing antibody 5J8 bound to 2009 pandemic influenza hemagglutinin, HA1 subunit HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Hong, M., Lee, P.S., Wilson, I.A. 2.25 X-RAY DIFFRACTION 0.238 0.191 False True IGHV4 IGLV3 Lambda 5e-09 -11.324631107601816 BLI TBD 1jps H L 0 T protein tissue factor IMMUNE SYSTEM 08/03/01 Crystal structure of tissue factor in complex with humanized Fab D3h44 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Faelber, K., Kirchhofer, D., Presta, L., Kelley, R.F., Muller, Y.A. 1.85 X-RAY DIFFRACTION 0.224 0.201 False True IGHV3 IGKV1 Kappa 1.00e-10 -13.63 SPR 25 11307801 5mvj H L 0 IMMUNE SYSTEM 01/16/17 Structure of DC8E8 Fab at pH 6.5 crystallized in space-group P1 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.5 X-RAY DIFFRACTION 0.272 0.219 False False IGHV1 IGKV8 Kappa None None None None None 4uao C B 0 A protein apical merozoite antigen 1 CELL INVASION 08/11/14 Crystal structure of Apical Membrane Antigen 1 from Plasmodium Knowlesi in complex with an invasion inhibitory antibody PLASMODIUM KNOWLESI; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus plasmodium knowlesi Vulliez-Le Normand, B., Saul, F.A., Bentley, G.A. 3.1 X-RAY DIFFRACTION 0.266 0.188 False False IGHV5 IGKV14 Kappa None None None None None 7e8c M J 0 A protein NA 368-2 h VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7ps2 H L 0 G protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-29 and Beta-53 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.99 X-RAY DIFFRACTION 0.266 0.233 False True IGHV5 IGKV3 Kappa None None None None None 1lk3 I M 0 B protein interleukin-10 IMMUNE SYSTEM 04/23/02 ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Josephson, K., Jones, B.C., Walter, L.J., DiGiacomo, R., Indelicato, S.R., Walter, M.R. 1.91 X-RAY DIFFRACTION 0.240 0.187 False False IGHV1 IGKV3 Kappa None None None None None 7ew5 g j 0 Y protein NA major capsid protein l1 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 7zfe M N 0 C protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV3 IGKV3 Kappa None None None None None 7p5w L NA 0 F protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2dqi H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/26/06 Crystal structure of hyhel-10 FV mutant (Ly50a) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 2.0 X-RAY DIFFRACTION 0.257 0.218 False True IGHV3 IGKV5 Kappa None None None None None 4hj0 C D 0 B protein gastric inhibitory polypeptide receptor IMMUNE SYSTEM 10/12/12 Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Madhurantakam, C., Ravn, P., Gruetter, M.G., Jackson, R.H. 3.0 X-RAY DIFFRACTION 0.311 0.255 False True IGHV1 IGLV1 Lambda 2.3e-08 -10.420467653019871 SPR TBD 3ejz C D 0 A protein h(+)/cl(-) exchange transporter clca IMMUNE SYSTEM/PROTON TRANSPORT 09/18/08 Structure of E203V mutant E.coli Cl-/H+ exchanger, CLC-ec1 ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.9 X-RAY DIFFRACTION 0.281 0.252 False False IGHV4 IGKV4 Kappa None None None None None 6xrj E F 0 NA NA NA NA IMMUNE SYSTEM 07/13/20 Crystal structure of the disulfide linked DH717.1 Fab dimer, derived from a macaque HIV-1 vaccine-induced Env glycan-reactive neutralizing antibody B cell lineage HOMO SAPIENS homo sapiens homo sapiens Manne, K., Nicely, N.I., Acharya, P. 3.15 X-RAY DIFFRACTION 0.282 0.245 False True IGHV4 IGLV2 Lambda None None None None None 4f3f B A 0 C protein mesothelin IMMUNE SYSTEM 05/09/12 Crystal Structure of Msln7-64 MORAb-009 FAB complex HOMO SAPIENS; ESCHERICHIA COLI homo sapiens Xia, D., Pastan, I., Ma, J., Tang, W.K., Esser, L. 2.65 X-RAY DIFFRACTION 0.222 0.177 False True IGHV1 IGKV4 Kappa 7.2e-10 -12.472830103186848 SPR TBD 2h2s E F 0 B protein clc cl transporter ION TRANSPORT 05/19/06 Crystal Structure of E148A mutant of CLC-ec1 in SeCN- ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Nguitragool, W., Miller, C. 3.1 X-RAY DIFFRACTION 0.282 0.281 False False IGHV4 IGKV4 Kappa None None None None None 3csy E F 0 L | K protein | protein NA | NA envelope glycoprotein gp2 | envelope glycoprotein gp1 IMMUNE SYSTEM/VIRAL PROTEIN 04/10/08 Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor HOMO SAPIENS; ZAIRE EBOLA VIRUS homo sapiens homo sapiens zaire ebola virus | zaire ebola virus Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O. 3.4 X-RAY DIFFRACTION 0.302 0.261 False True IGHV3 IGKV4 Kappa None None None None None 5nh3 I M 0 B protein activin receptor type-2a TRANSFERASE 03/21/17 CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV HOMO SAPIENS homo sapiens homo sapiens homo sapiens Scheufler, C. 2.35 X-RAY DIFFRACTION 0.208 0.166 False False IGHV1 IGLV2 Lambda 9.73e-10 -12.294413792096064 Unknown TBD 3fku U u 0 H | G protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/17/08 Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens influenza a virus | influenza a virus Hwang, W.C., Santelli, E., Stec, B., Wei, G., Cadwell, G., Bankston, L.A., Sui, J., Perez, S., Aird, D., Chen, L.M., Ali, M., Murakami, A., Yammanuru, A., Han, T., Cox, N., Donis, R.O., Liddington, R.C., Marasco, W.A. 3.2 X-RAY DIFFRACTION 0.286 0.232 True True unknown unknown unknown 1.30E-10 -13.48 SPR 25 19234466 7e9g D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/04/21 Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 HOMO SAPIENS; LAMA GLAMA homo sapiens homo sapiens | homo sapiens Lin, S., Han, S., Zhao, Q., Wu, B. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7v9l N NA 0 A | Y | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/26/21 Cryo-EM structure of the SV1-Gs complex. HOMO SAPIENS; BOS TAURUS; SYNTHETIC CONSTRUCT; RATTUS NORVEGICUS synthetic construct homo sapiens | bos taurus | rattus norvegicus Cong, Z.T., Zhou, F.L., Zhang, C., Zou, X.Y., Zhang, H.B., Wang, Y.Z., Zhou, Q.T., Cai, X.Q., Liu, Q.F., Li, J., Shao, L.J., Mao, C.Y., Wang, X., Wu, J.H., Xia, T., Zhao, L.H., Jiang, H.L., Zhang, Y., Xu, H.E., Cheng, X., Yang, D.H., Wang, M.W. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2z92 A B 0 A Hapten ENE (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL IMMUNE SYSTEM 09/14/07 Crystal structure of the Fab fragment of anti-ciguatoxin antibody 10C9 in complex with CTX3C_ABCDE MUS MUSCULUS mus musculus mus musculus mus musculus Ui, M., Tanaka, Y., Tsumoto, K. 2.3 X-RAY DIFFRACTION 0.269 0.228 False True IGHV3 IGKV4 Kappa 1.11e-08 -10.85 ITC 25 18463096 4n1e NA B 0 I protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 7ndc H L 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-159 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6rcv J I 0 F protein reticulocyte binding protein homologue 5 CELL ADHESION 04/11/19 PfRH5 bound to monoclonal antibodies R5.011 and R5.016 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Alanine, D.W.G., Draper, S.J., Higgins, M.K. 3.582 X-RAY DIFFRACTION 0.305 0.280 False True IGHV1 IGKV1 Kappa None None None None None 7zfa H L 0 A protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV4 IGKV1 Kappa None None None None None 5e5m D NA 0 C protein cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 10/08/15 Crystal structure of mouse CTLA-4 in complex with nanobody MUS MUSCULUS mus musculus mus musculus Fedorov, A.A., Fedorov, E.V., Samanta, D., Bonanno, J.B., Almo, S.C. 2.182 X-RAY DIFFRACTION 0.247 0.193 False True IGHV1 None None None None None 5cp3 H A 0 A Hapten YTZ 4-AMINO-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE IMMUNE SYSTEM 07/21/15 Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides in Complex with Sulfathiazole MUS MUSCULUS mus musculus mus musculus mus musculus Wang, Z., Shen, J., Li, C., Li, Y., Wen, K., Yu, X., Zhang, X. 1.99 X-RAY DIFFRACTION 0.266 0.214 False False IGHV3 IGKV1 Kappa None None None None None 7b2q D NA 0 C | B protein | protein NA | NA complement c4 gamma chain | complement c4 alpha chain IMMUNE SYSTEM 11/27/20 Cryo-EM structure of complement C4b in complex with nanobody B12 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Oosterheert, W., De la O Becerra, K.I., Gros, P. 3.76 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4hg4 P Q 0 D | a protein | protein NA | NA hemagglutinin ha2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 6mvl H L 0 A protein v-type immunoglobulin domain-containing suppressor of t-cell activation IMMUNE SYSTEM 10/26/18 Crystal structure of VISTA bound to a pH-selective antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Critton, D.A. 1.61 X-RAY DIFFRACTION 0.225 0.182 False True IGHV3 IGKV3 Kappa None None None None None 4x7f D NA 0 B protein capsid protein VIRAL PROTEIN 12/09/14 Crystal structure of norovirus GII.10 P domain in complex with Nano-25 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, G.S. 1.7 X-RAY DIFFRACTION 0.187 0.160 False True IGHV1 2.8000000000000003e-08 -10.303920013991087 ITC TBD 6ev2 A B 0 A carbohydrate BGC BETA-D-GLUCOSE IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan in complex with laminarihexaose MUS MUSCULUS mus musculus mus musculus mus musculus Sung, K.H., Josewski, J., Duebel, S., Blankenfeldt, W., Rau, U. 2.403 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV4 Kappa None None None None None 5ayu H L 0 IMMUNE SYSTEM 09/04/15 Crystal structure of HyHEL-10 Fv MUS MUSCULUS mus musculus mus musculus Nakanishi, T., Tsumoto, K., Yokota, A., Kondo, H., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.234 0.191 False True IGHV3 IGKV5 Kappa None None None None None 7n6p H L 0 NA NA NA NA IMMUNE SYSTEM 06/08/21 Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab HOMO SAPIENS homo sapiens homo sapiens Milligan, J.C., Yu, X., Buck, T., Saphire, E.O. 2.15 X-RAY DIFFRACTION 0.231 0.175 False True IGHV1 IGKV4 Kappa None None None None None 4yhp E F 0 IMMUNE SYSTEM 02/27/15 Crystal structure of 309M3-B Fab in complex with H3K9me3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Hattori, T., Dementieva, I.S., Montano, S.P., Koide, S. 2.53 X-RAY DIFFRACTION 0.250 0.211 False True IGHV3 IGLV3 Lambda 2e-09 -11.867518412372508 Unknown TBD 5k9q U V 0 P | Q protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.503 X-RAY DIFFRACTION 0.218 0.182 False True IGHV1 IGKV1 Kappa None None None None None 5y9f P O 0 C protein NA light chains of fab fragment of antibody 28f10 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 5i15 H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1-69/IGKV1-39 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.6 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 IGKV1 Kappa None None None None None 7bud G I 0 B protein NA dengue virus serotype 2 e protein VIRUS 04/06/20 Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 8.0 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 4krm F NA 0 E protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.655 X-RAY DIFFRACTION 0.244 0.208 False True IGHV1 None None None None None 5wtg B A 0 IMMUNE SYSTEM 12/11/16 Crystal structure of the Fab fragment of anti-HAV antibody R10 MUS MUSCULUS mus musculus mus musculus Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z. 2.907 X-RAY DIFFRACTION 0.266 0.201 False False IGHV5 IGKV4 Kappa None None None None None 7czu H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B6_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6z3p H L 0 C | A | B protein | protein | protein NA | NA | NA vp3 | vp1 | vp2 VIRUS 05/21/20 Structure of EV71 in complex with a protective antibody 38-3-11A Fab HOMO SAPIENS; ENTEROVIRUS A71 homo sapiens homo sapiens enterovirus a71 | enterovirus a71 | enterovirus a71 Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 4zs6 C D 0 B protein s protein IMMUNE SYSTEM 05/13/15 Receptor binding domain and Fab complex HOMO SAPIENS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Yu, X., Wang, X. 3.166 X-RAY DIFFRACTION 0.245 0.203 False True IGHV3 IGKV1 Kappa 3.12e-07 -8.875561141727196 SPR TBD 3rif H L 0 A protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.345 X-RAY DIFFRACTION 0.271 0.248 False True IGHV1 IGLV1 Lambda None None None None None 2ok0 H L 0 D nucleic-acid 5'-d(*tp*c)-3' IMMUNE SYSTEM/DNA 01/15/07 Fab ED10-DNA complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Sanguineti, S., Wilson, I.A., de Prat-Gay, G. 1.89 X-RAY DIFFRACTION 0.204 0.177 False False IGHV1 IGKV1 Kappa None None None None None 7sc1 P Q 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, R40-1G8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6srx I M 0 PROTEIN BINDING 09/06/19 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021158 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 1.9 X-RAY DIFFRACTION 0.261 0.234 False False IGHV3 IGLV1 Lambda None None None None None 6oz6 H NA 0 D protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to 3'-hydroxymureidomycin A LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.7 X-RAY DIFFRACTION 0.301 0.257 False True IGHV1 None None None None None 1u8h B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.1 X-RAY DIFFRACTION 0.236 0.221 False False IGHV2 IGKV1 Kappa None None None None None 7akd H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/30/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the 47D11 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fedry, J., Hurdiss, D.L., Wang, C., Li, W., Obal, G., Drulyte, I., Howes, S.C., van Kuppeveld, F.J.M., Foerster, F., Bosch, B.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 1n7m L H 0 L Hapten MMP N-METHYLMESOPORPHYRIN IMMUNE SYSTEM 11/15/02 Germline 7G12 with N-methylmesoporphyrin MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Yin, J., Andryski, S.E., Beuscher IV, A.E., Stevens, R.C., Schultz, P.G. 1.8 X-RAY DIFFRACTION 0.253 0.220 False True IGHV1 IGKV6 Kappa 1.96e-06 -7.78 SPR 12552112 3u7w H L 0 IMMUNE SYSTEM 10/14/11 Crystal structure of NIH45-46 Fab HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Bjorkman, P.J. 2.6 X-RAY DIFFRACTION 0.238 0.184 False True unknown IGKV3 Kappa None None None None None 6k69 NA A 0 B protein engineered t4 lysozyme STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (9213-3LRH) HOMO SAPIENS; ENTEROBACTERIA PHAGE T4 homo sapiens enterobacteria phage t4 Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 2.401 X-RAY DIFFRACTION 0.234 0.204 False True IGLV1 Lambda None None None None None 3ogo G NA 0 B protein green fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 08/17/10 Structure of the GFP:GFP-nanobody complex at 2.8 A resolution in spacegroup P21212 AEQUOREA VICTORIA; CAMELUS DROMEDARIUS camelus dromedarius aequorea victoria Kubala, M.H., Kovtun, O., Alexandrov, K., Collins, B.M. 2.8 X-RAY DIFFRACTION 0.253 0.202 False True IGHV1 1.40e-09 -12.56 Other 37 20945358 4z5r W V 0 F protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 6bae B A 0 C | E protein | protein NA | NA immunoglobulin g binding protein a | protein l IMMUNE SYSTEM 10/12/17 Trastuzumab Fab v3 in complex with CQFDLSTRRLKC MUS MUSCULUS; HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens staphylococcus aureus | finegoldia magna Bzymek, K.P., King, J.D., Williams, J.C. 2.14 X-RAY DIFFRACTION 0.224 0.173 False True IGHV3 IGKV1 Kappa None None None None None 7f58 N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/21 Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Zhang, H., Chen, L., Mao, C., Shen, Q., Yang, D., Shen, D., Qin, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3iy2 B A 0 IMMUNE SYSTEM 04/09/09 Variable domains of the computer generated model (WAM) of Fab 6 fitted into the cryoEM reconstruction of the virus-Fab 6 complex MUS MUSCULUS mus musculus mus musculus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Chipman, P.R., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 18 ELECTRON MICROSCOPY False False IGHV1 IGKV12 Kappa None None None None None 7bnw D NA 0 NA NA NA NA IMMUNE SYSTEM 01/22/21 Llama nanobody nb18 raised against GldL from Flavobacterium jonhsoniae LAMA GLAMA lama glama Trinh, N.T., Cambillau, C., Leone, P. 2.59 X-RAY DIFFRACTION 0.243 0.193 False True IGHV1 NA NA None None None None None 6bit J L 0 G protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 11/03/17 SIRPalpha antibody complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Ring, N.G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J.P., George, B.M., Lietzenmayer, M., McKenna, K.M., Naik, T.J., McCarty, A., Zheng, Y., Ring, A.M., Flavell, R.A., Weissman, I.L. 2.191 X-RAY DIFFRACTION 0.240 0.210 False False IGHV14 IGKV4 Kappa 2.6e-09 -11.712071867460315 SPR TBD 3stz A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 07/11/11 KcsA potassium channel mutant Y82C with nitroxide spin label STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Raghuraman, H., Cordero-Morales, J., Jogini, V., Perozo, E. 2.5 X-RAY DIFFRACTION 0.285 0.246 False False IGHV1 IGKV5 Kappa None None None None None 4iml A B 0 IMMUNE SYSTEM 01/03/13 CrossFab binding to human Angiopoietin 2 HOMO SAPIENS homo sapiens homo sapiens Fenn, S., Schiller, C., Griese, J., Hopfner, K.-P., Kettenberger, H. 2.931 X-RAY DIFFRACTION 0.269 0.237 False True IGHV1 IGLV3 Lambda None None None None None 7tet H L 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in non-active2-like conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 4.45 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 6jfi H L 0 E protein zikv structural protein e VIRUS 04/10/19 The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q. 11 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 5yd4 A a 0 B peptide epitope peptide (mutation t6a) IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide (mutation T6A) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.173 0.135 True True unknown unknown unknown None None None None None 1dn0 B A 0 IMMUNE SYSTEM 12/15/99 STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ HOMO SAPIENS homo sapiens homo sapiens Cauerhff, A., Braden, B., Carvalho, J.G., Leoni, J., Polikarpov, I., Goldbaum, F. 2.28 X-RAY DIFFRACTION 0.240 0.180 False False IGHV4 IGKV3D Kappa None None None None None 5i18 H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1-69/IGKV4-1 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 1.92 X-RAY DIFFRACTION 0.213 0.167 False True IGHV1 IGKV4 Kappa None None None None None 5kov C c 0 A protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 3l7f H L 0 IMMUNE SYSTEM 12/28/09 Structure of IL-13 antibody H2L6, A humanized variant OF C836 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.6 X-RAY DIFFRACTION 0.243 0.205 False True IGHV2 IGKV3 Kappa None None None None None 2qr0 R Q 0 P protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 7zfb N NA 0 F protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.08 X-RAY DIFFRACTION 0.308 0.261 False True IGHV1 NA NA None None None None None 7ri1 B NA 0 A protein NA glycoprotein 120 IMMUNE SYSTEM 07/19/21 Crystal structure of anti-HIV llama VHH antibody A12 in complex with HIV-1 C1086 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.55 X-RAY DIFFRACTION 0.225 0.176 False True unknown unknown unknown None None None None None 1cgs H L 0 IMMUNOGLOBULIN 10/06/93 LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB MUS MUSCULUS mus musculus Guddat, L.W., Shan, L., Edmundson, A.B. 2.6 X-RAY DIFFRACTION unknown 0.218 False True IGHV1 IGKV1 Kappa None None None None None 6pxh C D 0 A protein mers-cov s1-ntd IMMUNE SYSTEM/Viral protein 07/26/19 Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Wang, N., McLellan, J.S. 2.3 X-RAY DIFFRACTION 0.213 0.180 False True IGHV1 IGKV3 Kappa None None None None None 7sn3 NA E 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/21 Structure of human SARS-CoV-2 spike glycoprotein trimer bound by neutralizing antibody C1C-A3 Fab (variable region) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Shankar, S. 3.1 ELECTRON MICROSCOPY NA NA False True NA IGKV3 Kappa None None None None None 5jym D d 0 C protein cadherin-3 CELL ADHESION/IMMUNE SYSTEM 05/14/16 Human P-cadherin EC12 with scFv TSP11 bound HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Caaveiro, J.M.M., Kudo, S., Tsumoto, K. 2.45 X-RAY DIFFRACTION 0.270 0.223 True True unknown unknown unknown None None None None None 7cec H I 0 B protein NA integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 06/22/20 Structure of alpha6beta1 integrin in complex with laminin-511 HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Miyazaki, N., Takagi, J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV8 IGKV4 Kappa None None None None None 6w41 H L 0 C protein spike glycoprotein receptor binding domain IMMUNE SYSTEM/VIRAL PROTEIN 03/09/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wu, N.C., Zhu, X.Y., Wilson, I.A. 3.084 X-RAY DIFFRACTION 0.243 0.223 False True IGHV5 IGKV4 Kappa None None None None None 6tke H L 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 ChiLob 7/4 H2 HC-C224S Kappa LC-C214S F(ab')2 HOMO SAPIENS Orr, C.M., Fisher, H., Tews, I. 2.35 X-RAY DIFFRACTION 0.245 0.192 False False IGHV1 IGKV10 Kappa None None None None None 3oke B A 0 B carbohydrate KO2 PROP-2-EN-1-YL D-GLYCERO-ALPHA-D-TALO-OCT-2-ULOPYRANOSIDONIC ACID IMMUNE SYSTEM 08/24/10 Crystal structure of S25-39 in complex with Ko MUS MUSCULUS mus musculus mus musculus mus musculus Blackler, R.J., Evans, S.V. 2.4 X-RAY DIFFRACTION 0.289 0.221 False False IGHV7 IGKV8 Kappa None None None None None 6ldy A B 0 C peptide NA methylated peptide IMMUNE SYSTEM 11/23/19 Structure antibody D6 in complex with methylated peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Tsumoto, K. 1.77 X-RAY DIFFRACTION 0.218 0.185 False True IGHV1 IGKV1 Kappa None None None None None 1bfo H G 0 ANTIBODY 05/20/98 CAMPATH-1G IGG2B RAT MONOCLONAL FAB RATTUS RATTUS rattus rattus rattus rattus Cheetham, G.M.T., Hale, G., Waldmann, H., Bloomer, A.C. 2.6 X-RAY DIFFRACTION 0.263 0.192 False False IGHV7 IGKV22 Kappa None None None None None 7a29 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/16/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) 2-up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1eeu NA A 0 IMMUNE SYSTEM 02/03/00 M4L/Y(27D)D/Q89D/T94H mutant of LEN HOMO SAPIENS homo sapiens Pokkuluri, P.R., Cai, X., Gu, M., Stevens, F.J., Schiffer, M. 1.6 X-RAY DIFFRACTION 0.222 0.194 False True IGKV4 Kappa None None None None None 1mcr NA A 0 P peptide peptide n-acetyl-l-his-d-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 3stl A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 07/11/11 KcsA potassium channel mutant Y82C with Cadmium bound STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Raghuraman, H., Cordero-Morales, J., Jogini, V., Perozo, E. 2.4 X-RAY DIFFRACTION 0.263 0.227 False False IGHV1 IGKV5 Kappa None None None None None 6dc5 H I 0 G protein rsv fusion glycoprotein IMMUNE SYSTEM 05/04/18 RSV prefusion F in complex with AM22 Fab HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Jones, H.G., McLellan, J.S. 3.5 X-RAY DIFFRACTION 0.280 0.217 False True IGHV1 IGKV3 Kappa None None None None None 5xaj E C 0 IMMUNE SYSTEM 03/13/17 Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex. DENGUE VIRUS dengue virus dengue virus Wong, Y.H., Goh, B.C., Lescar, J. 2.5 X-RAY DIFFRACTION 0.239 0.185 False True IGHV1 IGLV3 Lambda None None None None None 3so3 C B 0 A protein suppressor of tumorigenicity 14 protein HYDROLASE 06/29/11 Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schneider, E.L., Farady, C.J., Egea, P.F., Goetz, D.H., Baharuddin, A., Craik, C.S. 2.1 X-RAY DIFFRACTION 0.194 0.161 False True IGHV3 IGKV3 Kappa None None None None None 2mkw NA A 8 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 2otw B A 0 E peptide poly-gln peptide antigen IMMUNE SYSTEM 02/09/07 Crystal structure of Fv polyglutamine complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Li, P. 2.35 X-RAY DIFFRACTION 0.258 0.226 False True IGHV5 IGLV3 Lambda None None None None None 6psc C c 0 IMMUNE SYSTEM 06/17/20 Antibody scFv-M204 trimeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 3.6 X-RAY DIFFRACTION 0.282 0.252 True True unknown unknown unknown None None None None None 4om0 H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07-G54Y in complex with clade A/E 93TH057 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.289 X-RAY DIFFRACTION 0.247 0.191 False True unknown IGKV3 Kappa None None None None None 2mmx NA A 19 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 5uk4 b NA 0 B protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 5mvz H L 0 U protein interleukin-1 beta SIGNALING PROTEIN 01/17/17 Fab 4AB007 bound to Interleukin-1-beta HOMO SAPIENS homo sapiens homo sapiens homo sapiens Stark, W., Seibert, V. 2.15 X-RAY DIFFRACTION 0.281 0.219 False True IGHV5 IGKV3 Kappa None None None None None 5bo1 I M 0 A protein protein jagged-1 Signaling protein/Immune system 05/26/15 Crystal structure of a human Jag1 fragment in complex with an anti-Jag1 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Payandeh, J., de Leon-Boenig, G. 2.56 X-RAY DIFFRACTION 0.259 0.220 False True IGHV3 IGKV1 Kappa 7.900000000000001e-10 -12.41785844031504 SPR TBD 4om1 H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07-I30Q, G54W, S58N in complex with clade A/E 93TH057 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.131 X-RAY DIFFRACTION 0.226 0.191 False True unknown IGKV3 Kappa None None None None None 5kaq F G 0 C protein hemagglutinin IMMUNE SYSTEM 06/01/16 Crystal structure of broadly neutralizing Influenza A antibody 31.a.83 in complex with Hemagglutinin Hong Kong 1968. INFLUENZA A VIRUS (A/HONG KONG/1-4-MA21-1/1968(H3N2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 3.514 X-RAY DIFFRACTION 0.313 0.270 False True IGHV3 IGKV3 Kappa None None None None None 4n8c H L 0 X peptide extracellular domain of influenza matrix protein 2 IMMUNE SYSTEM 10/17/13 Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus influenza a virus (a/puerto rico/8/1934(h1n1)) Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H. 1.6 X-RAY DIFFRACTION 0.242 0.193 False False IGHV1 IGKV8 Kappa 4.0000000000000007e-10 -12.821084109462982 Unknown TBD 6xym B NA 0 NA NA NA NA IMMUNE SYSTEM 01/30/20 Nbe-LBM LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.2 X-RAY DIFFRACTION 0.198 0.154 False True IGHV1 NA NA None None None None None 6me1 A B 0 F peptide envelope glycoprotein gp160 VIRAL PROTEIN 09/05/18 Crystal structure of the clade B isolate B41 mutant fusion peptide (residues 512-521) in complex with VRC34.01 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus type 1 Kumar, S., Sarkar, A., Wilson, I.A. 1.97 X-RAY DIFFRACTION 0.238 0.199 False True IGHV1 IGKV1 Kappa None None None None None 5u8q H L 0 A protein insulin-like growth factor 1 receptor TRANSFERASE 12/14/16 Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lawrence, M., Xu, Y. 3.27104 X-RAY DIFFRACTION 0.303 0.260 False True IGHV1 IGKV5 Kappa 2.4e-06 -7.666763597229133 ITC TBD 1ic5 H L 0 Y protein lysozyme c PROTEIN BINDING/HYDROLASE 03/30/01 CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD99A)-HEN LYSOZYME COMPLEX MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Yokota, A., Tsumoto, K., Kondo, H., Nishimiya, Y., Horii, K., Matsushima, M., Ogasahara, K., Yutani, K., Kumagai, I. 2.3 X-RAY DIFFRACTION 0.252 0.165 False True IGHV3 IGKV5 Kappa None None None None None 5vl2 B NA 0 B Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 2kh2 B b 71 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6urh H L 0 C protein hcv envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 10/23/19 Crystal structure of broadly neutralizing antibody AR3X in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain HEPACIVIRUS C; HOMO SAPIENS homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 2.2 X-RAY DIFFRACTION 0.233 0.187 False True IGHV1 IGKV3 Kappa None None None None None 7kfh G J 0 A protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437 EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4r7n I J 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 6ye3 D E 0 F protein NA interleukin-2 PROTEIN BINDING 03/23/20 IL-2 in complex with a Fab fragment from UFKA-20 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Karakus, U., Mittl, P., Boyman, O. 2.89 X-RAY DIFFRACTION 0.283 0.215 False True IGHV5 IGKV8 Kappa None None None None None 7fjo H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/04/21 Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with three T6 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Zhang, S., Liang, Q. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7z1e F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-H4 Q98R H100E bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Mikolajek, H., Naismith, J.H. 1.59 X-RAY DIFFRACTION 0.202 0.161 False False IGHV1 NA NA None None None None None 6n8d D B 0 A protein major capsid protein IMMUNE SYSTEM 11/29/18 Crystal structure of GII.4 2002 norovirus P domain in complex with neutralizing human antibody A1431 NOROVIRUS HU/GII.4/FARMINGTON HILLS/2004/USA; HOMO SAPIENS homo sapiens homo sapiens norovirus hu/gii.4/farmington hills/2004/usa Changela, A., Verardi, R., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.227 0.176 False True IGHV3 IGKV3 Kappa None None None None None 7lf0 F H 0 C protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6xw4 D NA 0 B protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5867 MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 2.19 X-RAY DIFFRACTION 0.218 0.173 False True IGHV1 None None None None None 2q1e NA C 0 PROTEIN FIBRIL 05/24/07 Altered dimer interface decreases stability in an amyloidogenic kappa1 Bence Jones protein. HOMO SAPIENS homo sapiens Thompson, J.R., Ramirez-Alvarado, M., Baden, E.M. 2.55 X-RAY DIFFRACTION 0.206 0.165 False True IGKV1 Kappa None None None None None 4jo4 H L 0 IMMUNE SYSTEM 03/16/13 Crystal structure of rabbit mAb R20 Fab ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Pan, R.M., Kong, X.P. 2.27 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV1 Kappa None None None None None 6mtn H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/20/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor Compound 484 in Complex with Human Antibodies 3H109L and 35O22 at 3.0 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.263 0.223 False True IGHV4 unknown unknown None None None None None 1mcl NA B 0 P peptide n-acetyl-d-his-l-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 3qum B A 0 P protein prostate-specific antigen IMMUNE SYSTEM 02/24/11 Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Stura, E.A., Muller, B.H., Michel, S., Ducancel, F. 3.2 X-RAY DIFFRACTION 0.294 0.198 False False IGHV1 IGKV3 Kappa None None None None None 1g7i B A 0 C protein lysozyme c HYDROLASE INHIBITOR/HYDROLASE 11/10/00 CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92F) MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Sundberg, E.J., Urrutia, M., Braden, B.C., Isern, J., Mariuzza, R.A. 1.8 X-RAY DIFFRACTION 0.248 0.188 False True IGHV2 IGKV12 Kappa None None None None None 1dbb H L 0 H Hapten STR PROGESTERONE IMMUNOGLOBULIN 11/11/92 THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Arevalo, J.H., Wilson, I.A. 2.7 X-RAY DIFFRACTION unknown 0.210 False True IGHV9 IGKV1 Kappa 1e-09 -12.27819680469229 Unknown TBD 6h71 D NA 0 B protein NA capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-94 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 2.313 X-RAY DIFFRACTION 0.217 0.193 False True IGHV1 NA NA None None None None None 6k2i A NA 17 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 6mg5 NA A 0 B Hapten 6ZW 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one IMMUNE SYSTEM 04/10/19 Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1 HOMO SAPIENS homo sapiens homo sapiens Morgan, G.J., Yan, N.L., Mortenson, D.E., Stanfield, R.L., Wilson, I.A., Kelly, J.W. 1.8 X-RAY DIFFRACTION 0.263 0.204 False True IGLV6 Lambda None None None None None 3o2w H L 0 L Hapten O2W METHYL ({[(3AR,4R,7R,7AR)-2-(4-AMINOPHENYL)-1,3-DIOXOOCTAHYDRO-4H-4,7-ETHANOISOINDOL-4-YL]CARBAMOYL}OXY)ACETATE IMMUNE SYSTEM 07/22/10 Crystal structure of the 1E9 PheL89Ser/LeuH47Trp/MetH100bPhe Fab in complex with a 39A11 transition state analog MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Verdino, P., Wilson, I.A. 2.55 X-RAY DIFFRACTION 0.248 0.207 False True IGHV9 IGKV1 Kappa None None None None None 6ni3 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN/IMMUNE SYSTEM 12/26/18 B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex HOMO SAPIENS; ENTEROBACTERIA PHAGE RB59; LAMA GLAMA lama glama homo sapiens | homo sapiens | homo sapiens Nguyen, A.H., Thomsen, A.R.B., Cahill, T.J., des Georges, A., Lefkowitz, R.J. 3.8 ELECTRON MICROSCOPY False True IGHV3 None None None None None 7a3t H L 0 A protein NA core protein VIRAL PROTEIN 08/18/20 Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8 DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 2.65 X-RAY DIFFRACTION 0.254 0.207 False True IGHV3 IGKV3 Kappa None None None None None 4m43 H L 0 IMMUNE SYSTEM 08/06/13 Crystal structure of anti-rabies glycoprotein Fab 523-11 MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Wilson, I.A., Wunner, W.H. 1.85 X-RAY DIFFRACTION 0.232 0.194 False False IGHV1 IGKV5 Kappa None None None None None 1ezv X Y 0 E protein ubiquinol-cytochrome c reductase iron-sulfursubunit OXIDOREDUCTASE/ELECTRON TRANSPORT 05/12/00 STRUCTURE OF THE YEAST CYTOCHROME BC1 COMPLEX CO-CRYSTALLIZED WITH AN ANTIBODY FV-FRAGMENT SACCHAROMYCES CEREVISIAE; MUS MUSCULUS mus musculus mus musculus saccharomyces cerevisiae Hunte, C., Koepke, J., Lange, C., Rossmanith, T., Michel, H. 2.3 X-RAY DIFFRACTION 0.254 0.222 False True IGHV3 IGKV10 Kappa None None None None None 7k93 K k 0 D protein NA non-structural protein 1 VIRAL PROTEIN 09/28/20 DENV2 NS1 in complex with neutralizing 2B7 single chain Fab variable region (scFv) DENGUE VIRUS 2; MUS MUSCULUS mus musculus dengue virus 2 Akey, D.L., Smith, J.L. 2.89 X-RAY DIFFRACTION 0.269 0.223 True True unknown unknown unknown None None None None None 4jre H L 0 D protein nitrite extrusion protein 1 TRANSPORT PROTEIN/Immune System 03/21/13 Crystal structure of nitrate/nitrite exchanger NarK with nitrite bound ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Zheng, H., Wisedchaisri, G., Gonen, T. 2.8 X-RAY DIFFRACTION 0.269 0.223 False False IGHV9 IGKV19 Kappa None None None None None 7cn2 G g 0 E protein NA major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 07/29/20 Subparticle refinement of human papillomavirus type 16 pesudovirus in complex with H16.001 Fab HUMAN PAPILLOMAVIRUS TYPE 16; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human papillomavirus type 16 He, M.Z., Li, S.W. 3.43 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 7fei H L 0 2 | 1 protein | protein NA | NA capsid protein vp0 | capsid protein vp0 VIRUS 07/20/21 Complex of FMDV A/WH/CHA/09 and bovine neutralizing scFv antibody R55 BOS TAURUS; FOOT-AND-MOUTH DISEASE VIRUS - TYPE A bos taurus bos taurus foot-and-mouth disease virus - type a | foot-and-mouth disease virus - type a Yong, H., Kun, L., Zhiyong, L. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7l7r B A 0 G protein NA glycoprotein c VIRAL PROTEIN 12/30/20 CCHFV Gc prefusion monomer bound to ADI-36121 and ADI-37801 Fabs HOMO SAPIENS; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS (STRAIN NIGERIA/IBAR10200/1970) homo sapiens homo sapiens crimean-congo hemorrhagic fever virus (strainnigeria/ibar10200/1970) Mishra, A.K., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.244 0.219 False True IGHV3 IGKV1 Kappa None None None None None 1u8l B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide DLDRWAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.6 X-RAY DIFFRACTION 0.249 0.223 False False IGHV2 IGKV1 Kappa None None None None None 2kqm NA A 6 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6w1c J N 0 G protein NA e2 glycoprotein VIRUS/IMMUNE SYSTEM 03/04/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain MAYARO VIRUS (STRAIN BRAZIL); HOMO SAPIENS homo sapiens homo sapiens mayaro virus (strain brazil) Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 6mph 1 2 0 6 protein envelope glycoprotein gp41 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 7q9i E F 0 B protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-43 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6i9i H L 0 D protein glycoprotein VIRAL PROTEIN 11/23/18 Rift valley fever virus Gn in complex with a neutralizing antibody fragment ORYCTOLAGUS CUNICULUS; RIFT VALLEY FEVER VIRUS oryctolagus cuniculus oryctolagus cuniculus rift valley fever virus Allen, E.R., Bowden, T.A. 1.98 X-RAY DIFFRACTION 0.243 0.203 False True IGHV1 IGKV1 Kappa None None None None None 6udk M N 0 R protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7syz H L 0 A protein NA attachment glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/25/21 Hendra virus G protein head domain in complex with cross-neutralizing murine antibody hAH1.3 HENDRA HENIPAVIRUS; MUS MUSCULUS mus musculus mus musculus hendra henipavirus Xu, K., Xu, Y. 2.86 X-RAY DIFFRACTION 0.262 0.246 False True IGHV9 IGKV1 Kappa None None None None None 7e5s U Q 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 2h1p H L 0 P peptide pa1 COMPLEX (ANTIBODY/PEPTIDE) 11/12/97 THE THREE-DIMENSIONAL STRUCTURES OF A POLYSACCHARIDE BINDING ANTIBODY TO CRYPTOCOCCUS NEOFORMANS AND ITS COMPLEX WITH A PEPTIDE FROM A PHAGE DISPLAY LIBRARY: IMPLICATIONS FOR THE IDENTIFICATION OF PEPTIDE MIMOTOPES MUS MUSCULUS mus musculus mus musculus Young, A.C.M., Valadon, P., Casadevall, A., Scharff, M.D., Sacchettini, J.C. 2.4 X-RAY DIFFRACTION unknown 0.186 False False IGHV5 IGKV1 Kappa None None None None None 1ifh H L 0 P peptide influenza hemagglutinin ha1 (strain x47)(residues 101-107) IMMUNOGLOBULIN 05/06/93 A DETAILED ANALYSIS OF THE FREE AND BOUND CONFORMATION OF AN ANTIBODY: X-RAY STRUCTURES OF ANTI-PEPTIDE FAB 17(SLASH)9 AND THREE DIFFERENT FAB-PEPTIDE COMPLEXES MUS MUSCULUS mus musculus mus musculus Schulze-Gahmen, U., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.170 False True IGHV5 IGKV8 Kappa None None None None None 5nbw H L 0 L Hapten 8SK benzo[a]pyren-3-ol IMMUNE SYSTEM 03/02/17 Crystal structure of the Fab fragment 22F12 in complex with 3-hydroxybenzo[a]pyrene MUS MUSCULUS mus musculus mus musculus mus musculus Skerra, A., Eichinger, A. 2.4 X-RAY DIFFRACTION 0.228 0.180 False True IGHV1 IGKV14 Kappa None None None None None 2fed C D 0 A protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 12/15/05 Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C. 3.317 X-RAY DIFFRACTION 0.287 0.248 False True IGHV3 IGKV6D Kappa None None None None None 7aqx D NA 0 B protein NA variant surface glycoprotein mitat 1.2 MEMBRANE PROTEIN 10/23/20 Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB9) LAMA GLAMA; TRYPANOSOMA BRUCEI BRUCEI lama glama trypanosoma brucei brucei Stebbins, C.E., Hempelmann, A. 1.499 X-RAY DIFFRACTION 0.192 0.164 False True IGHV1 NA NA None None None None None 6c5k H L 0 H carbohydrate GP1 polysaccharide SUGAR BINDING PROTEIN 01/16/18 S25-23 Fab in complex with Chlamydiaceae LPS (Crystal form 2) MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.75 X-RAY DIFFRACTION 0.218 0.188 False False IGHV2 IGKV1 Kappa None None None None None 6be3 H L 0 H carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/24/17 Crystal structure of a polysaccharide-binding human Fab (F598) in complex with N-acetyl-D-glucosamine (GlcNAc) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Soliman, C., Ramsland, P.A. 1.6 X-RAY DIFFRACTION 0.200 0.166 False True IGHV4 IGLV4 Lambda None None None None None 6tkb I M 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 ChiLob 7/4 H2 HC-C224S F(ab')2 HOMO SAPIENS Orr, C.M., Fisher, H., Tews, I. 2.0 X-RAY DIFFRACTION 0.229 0.182 False False IGHV1 IGKV10 Kappa None None None None None 7vbi N NA 0 A | B protein | protein NA | NA isoform 3 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/31/21 Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex HOMO SAPIENS; ESCHERICHIA COLI; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Zhao, F.H., Zhou, Q.T., Cong, Z.T., Hang, K.N., Zou, X.Y., Zhang, C., Chen, Y., Dai, A.T., Liang, A.Y., Ming, Q.Q., Wang, M., Chen, L.N., Xu, P.Y., Chang, R.L., Feng, W.B., Xia, T., Zhang, Y., Wu, B.L., Yang, D.H., Zhao, L.H., Xu, H.E., Wang, M.W. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7aqz D NA 0 A protein NA variant surface glycoprotein mitat 1.2 MEMBRANE PROTEIN 10/23/20 Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB14) LAMA GLAMA; TRYPANOSOMA BRUCEI BRUCEI lama glama trypanosoma brucei brucei Stebbins, C.E., Hempelmann, A., VanStraaten, M. 1.3 X-RAY DIFFRACTION 0.172 0.151 False True IGHV1 NA NA None None None None None 3mnv D C 0 IMMUNE SYSTEM 04/22/10 Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment MUS MUSCULUS,HOMO SAPIENS mus musculus,homo sapiens mus musculus,homo sapiens Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 2.4 X-RAY DIFFRACTION 0.228 0.181 False True IGHV9 IGKV8 Kappa None None None None None 7oaq A NA 0 E protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody H3 AND C1 bound to RBD with Kent mutation LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 Naismith, J.H., Mikolajek, H. 1.55 X-RAY DIFFRACTION 0.178 0.155 False False IGHV1 NA NA None None None None None 4wfe G F 0 B protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 2.5 X-RAY DIFFRACTION 0.234 0.199 False True IGHV1 IGKV4 Kappa None None None None None 6vi4 C NA 0 B protein kappa opioid receptor MEMBRANE PROTEIN 01/11/20 Nanobody-Enabled Monitoring of Kappa Opioid Receptor States HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Che, T., Roth, B.L. 3.3 X-RAY DIFFRACTION 0.271 0.242 False True IGHV1 None None None None None 6yye C c 0 A protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 05/04/20 TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scFv-2) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Krojer, T., Mukhopadhyay, S.M.M., McKinley, G., Graslund, S., Wigren, E., Persson, H., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Di Daniel, E., Burgess-Brown, N., Bullock, A. 3.36 X-RAY DIFFRACTION 0.327 0.299 True True unknown unknown unknown None None None None None 6iyn A NA 10 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 5f7l B NA 0 A protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with Nanobody Nb-ER14 HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.74 X-RAY DIFFRACTION 0.265 0.212 False True IGHV1 None None None None None 7ejz H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/03/21 Complex Structure of antibody BD-503 and RBD-S477N of COVID-19 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xu, H., Wang, B., Zhao, T.N., Su, X.D. 3.63 X-RAY DIFFRACTION 0.284 0.241 False True IGHV3 IGKV1 Kappa None None None None None 6ldy H L 0 M peptide NA methylated peptide IMMUNE SYSTEM 11/23/19 Structure antibody D6 in complex with methylated peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Tsumoto, K. 1.77 X-RAY DIFFRACTION 0.218 0.185 False True IGHV1 IGKV1 Kappa None None None None None 6zdh D F 0 B protein NA spike glycoprotein VIRAL PROTEIN 06/14/20 SARS-CoV-2 Spike glycoprotein in complex with a neutralizing antibody EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6ks2 B A 0 NA NA NA NA IMMUNE SYSTEM 08/23/19 Structure of anti-Ghrelin receptor antibody MUS MUSCULUS mus musculus mus musculus Shiimura, Y., Horita, S., Asada, H., Hirata, K., Iwata, S., Kojima, M. 1.753 X-RAY DIFFRACTION 0.233 0.192 False True IGHV1 IGKV8 Kappa None None None None None 6p3s S T 0 U protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 1m71 B A 0 IMMUNE SYSTEM 07/18/02 Crystal structure of a Monoclonal Fab Specific for Shigella Flexneri Y lipopolysaccharide MUS MUSCULUS mus musculus mus musculus Vyas, N.K., Vyas, M.N., Chervenak, M.C., Johnson, M.A., Pinto, B.M., Bundle, D.R., Quiocho, F.A. 2.8 X-RAY DIFFRACTION 0.291 0.223 False True IGHV6 IGKV1 Kappa None None None None None 7pij K NA 0 NA NA NA NA MEMBRANE PROTEIN 08/20/21 Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA lama glama Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4nhh H L 0 IMMUNE SYSTEM 11/05/13 Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 6.5 X-RAY DIFFRACTION 0.366 0.381 False True unknown IGKV1 Kappa None None None None None 1fvc D C 0 IMMUNOGLOBULIN 10/20/92 X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Randal, M., Kossiakoff, A.A., Presta, L. 2.2 X-RAY DIFFRACTION unknown 0.183 False True IGHV3 IGKV1 Kappa None None None None None 6lxj M N 0 D protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9) INFLUENZA A VIRUS (A/ANHUI/1-BALF_RG44/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1-balf_rg44/2013(h7n9)) Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 2.903 X-RAY DIFFRACTION 0.241 0.193 False True IGHV1 IGLV2 Lambda None None None None None 6bli D E 0 F peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/10/17 RSV G peptide bound to Fab CB002.5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human respiratory syncytial virus a (strainrsb6256) Jones, H.G., McLellan, J.S., Langedijk, J.P. 2.12 X-RAY DIFFRACTION 0.218 0.169 False True IGHV4 IGKV1 Kappa 5.200000000000001e-10 -12.665637564550789 Unknown TBD 7dpm A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/20/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M. 3.304 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGKV1 Kappa None None None None None 6frj H h 0 B peptide apd-sethr-rp IMMUNE SYSTEM 02/16/18 Crystal structure of scFv-SM3 in complex with APD-SeThrGalNAc-RP MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus synthetic construct Companon, I., Castro-Lopez, J., Escudero-Casao, M., Avenoza, A., Busto, J.H., Castillon, S., Jimenez-Barbero, J., Bernardes, G.J., Boutureira, O., Jimenez-Oses, G., Asensio, J.L., Peregrina, J.M., Hurtado-Guerrero, R., Corzana, F. 1.4 X-RAY DIFFRACTION 0.230 0.205 True True unknown unknown unknown None None None None None 2kh2 B b 69 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6lun C D 0 NA NA NA NA STRUCTURAL PROTEIN 01/30/20 NN2101 Antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Kim, H.N., Seo, M.D., Park, S.K. 1.9 X-RAY DIFFRACTION 0.210 0.165 False True IGHV3 IGKV2 Kappa None None None None None 4jhw H L 0 F protein fusion glycoprotein f0 IMMUNE SYSTEM 03/05/13 Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS homo sapiens homo sapiens human respiratory syncytial virus Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S. 3.6 X-RAY DIFFRACTION 0.267 0.213 False True IGHV1 IGKV1 Kappa None None None None None 3ks0 H L 0 B protein cytochrome b2, mitochondrial OXIDOREDUCTASE 11/20/09 Crystal structure of the heme domain of flavocytochrome b2 in complex with Fab B2B4 SACCHAROMYCES CEREVISIAE; MUS MUSCULUS mus musculus mus musculus saccharomyces cerevisiae Golinelli-Pimpaneau, B., Lederer, F., Le, K.H.D. 2.7 X-RAY DIFFRACTION 0.289 0.214 False False IGHV3 IGLV1 Lambda None None None None None 5uk1 I i 0 E protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 3 HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); INFLUENZA A VIRUS homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 7dce H L 0 B | X protein | protein NA | NA isoform 2 of basigin | xk-related protein 8 TRANSPORT PROTEIN 10/26/20 Cryo-EM structure of human XKR8-basigin complex bound to Fab fragment HOMO SAPIENS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus homo sapiens | homo sapiens Sakuragi, T., Kanai, R., Tsutsumi, A., Narita, H., Onishi, E., Miyazaki, T., Baba, T., Nakagawa, A., Kikkawa, M., Toyoshima, C., Nagata, S. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6tnp D C 0 D unknown NO8 unknown IMMUNE SYSTEM 12/09/19 Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide MUS MUSCULUS mus musculus mus musculus mus musculus Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. 3.0 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV8 Kappa None None None None None 6wty K L 0 J protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 253245 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.481 X-RAY DIFFRACTION 0.301 0.262 False True IGHV1 IGLV2 Lambda None None None None None 5w23 H L 0 C protein fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/17 Crystal Structure of RSV F in complex with 5C4 Fab HUMAN RESPIRATORY SYNCYTIAL VIRUS A; MUS MUSCULUS mus musculus mus musculus human respiratory syncytial virus a Battles, M.B., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.239 0.198 False True IGHV14 IGKV3 Kappa None None None None None 6rcu E D 0 A protein reticulocyte binding protein homologue 5 CELL ADHESION 04/11/19 PfRH5 bound to monoclonal antibodies R5.004 and R5.016 PLASMODIUM FALCIPARUM (ISOLATE 3D7); HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Alanine, D.W.G., Draper, S.J., Higgins, M.K. 4.005 X-RAY DIFFRACTION 0.339 0.285 False True IGHV1 IGKV1 Kappa None None None None None 6x96 J K 0 G protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 10A fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 1f11 D C 0 IMMUNE SYSTEM 05/18/00 F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY MUS MUSCULUS mus musculus mus musculus Saul, F.A., Vulliez-Le Normand, B., Passafiume, M., Riottot, M.M., Bentley, G.A. 3.0 X-RAY DIFFRACTION 0.271 0.184 False False IGHV1 IGKV3 Kappa None None None None None 4yqx H L 0 A protein NA interleukin-2 CYTOKINE/IMMUNE SYSTEM 03/13/15 Mouse IL-2 Bound to JES6-1 scFv Fragment RATTUS NORVEGICUS; MUS MUSCULUS rattus norvegicus rattus norvegicus mus musculus Spangler, J.B., Luca, V.C., Jude, K.M., Garcia, K.C. 2.826 X-RAY DIFFRACTION 0.204 0.170 False True IGHV1 IGKV8 Kappa None None None None None 5fb8 B A 0 C protein pro-interleukin-16 IMMUNE SYSTEM 12/14/15 Structure of Interleukin-16 bound to the 14.1 antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Hall, G., Cowan, R., Bayliss, R., Carr, M. 2.07 X-RAY DIFFRACTION 0.205 0.172 False True IGHV1 IGKV3 Kappa None None None None None 6k2i A NA 3 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7cfm N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/27/20 Cryo-EM structure of the P395-bound GPBAR-Gs complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Yang, F., Mao, C., Guo, L., Lin, J., Ming, Q., Xiao, P., Wu, X., Shen, Q., Guo, S., Shen, D., Lu, R., Zhang, L., Huang, S., Ping, Y., Zhang, C., Ma, C., Zhang, K., Liang, X., Shen, Y., Nan, F., Yi, F., Luca, V., Zhou, J., Jiang, C., Sun, J., Xie, X., Yu, X., Zhang, Y. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6svl O P 0 R protein myeloid-derived growth factor CYTOKINE 09/18/19 human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ebenhoch, R., Nar, H. 1.58 X-RAY DIFFRACTION 0.206 0.181 False True IGHV14 IGKV12 Kappa None None None None None 1ap2 D C 0 IMMUNOGLOBULIN 07/23/97 SINGLE CHAIN FV OF C219 MUS MUSCULUS mus musculus mus musculus Hoedemaeker, P.J., Rose, D.R. 2.36 X-RAY DIFFRACTION 0.284 0.204 True True IGHV14 IGKV8 Kappa None None None None None 3hc3 H L 0 IMMUNE SYSTEM 05/05/09 BHA10 IgG1 Fab double mutant variant - antibody directed at human LTBR HOMO SAPIENS homo sapiens homo sapiens Arndt, J.W., Jordan, J.L., Lugovskoy, A., Wang, D. 1.72 X-RAY DIFFRACTION 0.190 0.158 False True IGHV1 IGKV1 Kappa None None None None None 6n1w M N 0 c protein unknown VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 5i2i D C 0 IMMUNE SYSTEM 02/08/16 Structure of cetuximab Fab with cyclic F3Q variant of the meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.551 X-RAY DIFFRACTION 0.205 0.160 False True IGHV2 IGKV5 Kappa None None None None None 5y9j H L 0 A protein tumor necrosis factor ligand superfamily member 13b PROTEIN BINDING 08/25/17 BAFF in complex with belimumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.-S., Shin, W. 2.05 X-RAY DIFFRACTION 0.217 0.180 False True IGHV1 IGLV3 Lambda None None None None None 6wzk A B 0 E protein NA c-x-c motif chemokine 3 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL3 HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Durbin, J.D., Druzina, Z. 1.8 X-RAY DIFFRACTION 0.209 0.178 False True IGHV1 IGKV3 Kappa None None None None None 4eow H L 0 IMMUNE SYSTEM 04/16/12 Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007 HOMO SAPIENS homo sapiens homo sapiens Blech, M. 1.97 X-RAY DIFFRACTION 0.257 0.224 False False IGHV7 IGLV1 Lambda None None None None None 6a77 H L 0 A protein roundabout homolog 1 IMMUNE SYSTEM 07/02/18 Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the Fab fragment of murine monoclonal antibody B5209B HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mizohata, E., Nakayama, T., Kado, Y., Inoue, T. 2.0 X-RAY DIFFRACTION 0.278 0.238 False True IGHV5 IGKV12 Kappa None None None None None 7ter H L 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 non-active2 conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 5.23 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 2x1p B NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama VandenAbbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., VanLoo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.1 X-RAY DIFFRACTION 0.220 0.203 False True IGHV1 None None None None None 2htl C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/26/06 Structure of the Escherichia coli ClC chloride channel Y445F mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.4 X-RAY DIFFRACTION 0.302 0.259 False False IGHV4 IGKV4 Kappa None None None None None 6ev1 I J 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Dubel, S., Blankenfeldt, W., Rau, U. 3.043 X-RAY DIFFRACTION 0.238 0.186 False True IGHV1 IGKV4 Kappa None None None None None 6vvu J K 0 B protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 02/18/20 Anti-Tryptase fab E104.v1 bound to tryptase HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Koerber, J.T. 3.0 X-RAY DIFFRACTION 0.232 0.187 False True IGHV4 IGKV1 Kappa None None None None None 4mwf A B 0 D protein envelope glycoprotein e2 IMMUNE SYSTEM 09/24/13 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core bound to broadly neutralizing antibody AR3C HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Kong, L., Wilson, I.A., Law, M. 2.645 X-RAY DIFFRACTION 0.270 0.231 False True IGHV1 IGKV3 Kappa None None None None None 3d69 H L 0 Immune System 05/19/08 Crystal Structure of the Fab Fragment of an Anti-Factor IX Antibody 10C12 HOMO SAPIENS mus musculus mus musculus Shi, X.L., Huang, M.D., Zeng, T. 3.77 X-RAY DIFFRACTION 0.342 0.249 False True IGHV3 IGLV1 Lambda None None None None None 7ley D E 0 A protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb5 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5bjz D H 0 B protein maltose-binding periplasmic protein SUGAR BINDING PROTEIN 09/12/17 Crystal structure of maltose binding protein in complex with an allosteric synthetic antibody ESCHERICHIA COLI O157:H7; HOMO SAPIENS homo sapiens homo sapiens escherichia coli o157 Mukherjee, S., Kossiakoff, A.A. 1.95 X-RAY DIFFRACTION 0.229 0.194 False True IGHV3 IGKV1 Kappa None None None None None 2gk0 H L 0 IMMUNE SYSTEM 03/31/06 Structure of Catalytic Elimination Antibody 13G5 from a twinned crystal in space group C2 MUS MUSCULUS mus musculus mus musculus Debler, E.W., Wilson, I.A. 2.45 X-RAY DIFFRACTION unknown unknown False False IGHV2 IGKV1 Kappa None None None None None 7si2 G F 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/12/21 Crystal structure of neutralizing antibody 10-28 in complex with SARS-CoV-2 spike receptor binding domain (RBD) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.2 X-RAY DIFFRACTION 0.261 0.198 False True IGHV3 IGKV1 Kappa None None None None None 2ipt H L 0 IMMUNE SYSTEM 10/12/06 PFA1 Fab Fragment MUS MUSCULUS mus musculus mus musculus Gardberg, A.S., Dealwis, C. 2.0 X-RAY DIFFRACTION 0.223 0.177 False False IGHV8 IGKV1 Kappa None None None None None 2fat H L 0 IMMUNE SYSTEM 12/07/05 An anti-urokinase plasminogen activator receptor (UPAR) antibody: Crystal structure and binding epitope MUS MUSCULUS mus musculus mus musculus Li, Y., Parry, G., Shi, X., Chen, L., Callahan, J.A., Mazar, A.P., Huang, M. 1.77 X-RAY DIFFRACTION 0.273 0.239 False False IGHV1 IGKV4 Kappa None None None None None 6ywc A B 0 C protein NA de novo design 4e1h_95 DE NOVO PROTEIN 04/29/20 De novo designed protein 4E1H_95 in complex with 101F antibody HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Yang, C., Sesterhenn, F., Pojer, F., Correia, B.E. 2.85 X-RAY DIFFRACTION 0.248 0.212 False True IGHV8 IGKV3 Kappa None None None None None 5dmi H L 0 A protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 09/08/15 Structure of the extracellular domain of the CD40 in complex with CHI220 FAB MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Sheriff, S. 3.69 X-RAY DIFFRACTION 0.207 0.168 False True IGHV9 IGKV5 Kappa 9.100000000000001e-10 -12.33407434312871 SPR TBD 7t5f F NA 0 D protein NA botulinum neurotoxin type b TOXIN 12/12/21 Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10 CLOSTRIDIUM BOTULINUM; CAMELIDAE camelidae clostridium botulinum Jin, R., Lam, K.-H. 2.6 X-RAY DIFFRACTION 0.222 0.194 False True IGHV1 NA NA None None None None None 7r8b C D 0 B | A protein | protein NA | NA atp-binding cassette sub-family g member 8 | atp-binding cassette sub-family g member 5 LIPID TRANSPORT 06/26/21 The structure of human ABCG5/ABCG8 supplemented with cholesterol HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Sun, Y., Li, X., Long, T. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV9 Kappa None None None None None 6xlq E F 0 D protein NA butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 06/29/20 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the CTX-2026 Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payne, K.K., Mine, J.A., Biswas, S., Chaurio, R.A., Perales-Puchalt, A., Anadon, C.M., Costich, T.L., Harro, C.M., Walrath, J., Ming, Q., Tcyganov, E., Buras, A.L., Rigolizzo, K.E., Mandal, G., Lajoie, J., Ophir, M., Tchou, J., Marchion, D., Luca, V.C., Bobrowicz, P., McLaughlin, B., Eskiocak, U., Schmidt, M., Cubillos-Ruiz, J.R., Rodriguez, P.C., Gabrilovich, D.I., Conejo-Garcia, J.R. 3.0 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV1 Kappa None None None None None 4yga B NA 0 A protein calmodulin-domain protein kinase 1 METAL BINDING PROTEIN 02/26/15 CDPK1, from Toxoplasma gondii, bound to inhibitory VHH-1B7 VICUGNA PACOS; TOXOPLASMA GONDII vicugna pacos toxoplasma gondii Knockenhauer, K.E., Schwartz, T.U. 2.94 X-RAY DIFFRACTION 0.262 0.226 False True IGHV1 None None None None None 6cm3 O N 0 E protein envelope glycoprotein gp160 VIRAL PROTEIN 03/02/18 BG505 SOSIP in complex with sCD4, 17b, 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 3.54 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7pi3 T U 0 O protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 4evn M N 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 5u0u G g 0 IMMUNE SYSTEM 11/27/16 Crystal Structure of DH270.1 (unliganded, single-chain Fv) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens Fera, D., Harrison, S.C. 3.428 X-RAY DIFFRACTION 0.282 0.254 True True unknown unknown unknown None None None None None 7k8s H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Malyutin, A.G., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6vi0 E D 0 C protein NA bg505 gp120 IMMUNE SYSTEM 01/10/20 Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.43 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 7cws E D 0 Q protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike Proteins Trimer in Complex with FC05 and H014 Fabs Cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L., Wang, X. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4m8q A B 0 S protein 4e10 epitope scaffold t117 IMMUNE SYSTEM 08/13/13 Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Finton, K.A.K. 2.89 X-RAY DIFFRACTION 0.302 0.261 False True IGHV1 IGKV3 Kappa 3.96e-09 -11.462794680024446 SPR TBD 6x3z J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.23 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 7wu3 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/05/22 Cryo-EM structure of the adhesion GPCR ADGRF1 in complex with miniGs HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Qu, X., Qiu, N., Wang, M., Zhao, Q., Wu, B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6xkq H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/26/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-250 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Zhu, X., Wu, N.C., Wilson, I.A. 2.55 X-RAY DIFFRACTION 0.255 0.204 False True IGHV1 IGLV2 Lambda None None None None None 7rth J I 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 5ggv H L 0 Y protein cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 06/16/16 CTLA-4 in complex with tremelimumab Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heo, Y.S. 1.998 X-RAY DIFFRACTION 0.214 0.181 False True IGHV3 IGKV1 Kappa None None None None None 6mqm D E 0 F peptide hiv env fusion peptide residue 512-519 IMMUNE SYSTEM 10/10/18 Vaccine-elicited NHP FP-targeting neutralizing antibody DF1W-a.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 3.484 X-RAY DIFFRACTION 0.246 0.200 False True IGHV4 IGKV2 Kappa None None None None None 2vh5 H L 0 R protein gtpase hras IMMUNE SYSTEM 11/19/07 CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tanaka, T., Williams, R.L., Rabbitts, T.H. 2.7 X-RAY DIFFRACTION 0.291 0.211 False True IGHV3 IGKV1 Kappa None None None None None 7ams H L 0 B protein NA human a6 t-cell receptor beta chain trbc2 IMMUNE SYSTEM 10/09/20 Crystal structure of the complex of the KFN mutant of HuJovi-1 Fab with human TRBC2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferrari, M., Bulek, A., Bughda, R., Jha, R., Welin, M., Svensson, A., Logan, D.T., Sewell, A., Onuoha, S., Pule, M. 2.419 X-RAY DIFFRACTION 0.225 0.180 False True IGHV1 IGKV1 Kappa None None None None None 5xez H L 0 B protein glucagon receptor,endolysin,glucagon receptor SIGNALING PROTEIN 04/06/17 Structure of the Full-length glucagon class B G protein-coupled receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens, enterobacteria phage t4 Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.Y., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. 3.0 X-RAY DIFFRACTION 0.243 0.210 False True IGHV3 IGKV1 Kappa None None None None None 7wpd Z NA 0 NA NA NA NA VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with one JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA lama glama Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6qtl B NA 0 H Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 4kxz N M 0 E protein transforming growth factor beta-2 immune system 05/28/13 crystal structure of tgfb2 in complex with GC2008. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mathieu, M., Moulin, A.G., Wei, R. 2.83 X-RAY DIFFRACTION 0.222 0.183 False True IGHV1 IGKV3 Kappa 3.0000000000000004e-09 -11.627286953008985 SPR TBD 6p95 D E 0 a | A protein | protein NA | NA unknown | pre-glycoprotein polyprotein gp complex viral protein/immune system 06/09/19 Structure of Lassa virus glycoprotein in complex with Fab 25.6A LASSA VIRUS; HOMO SAPIENS; LASSA VIRUS (STRAIN MOUSE/SIERRA LEONE/JOSIAH/1976) homo sapiens homo sapiens lassa virus (strain mouse/sierraleone/josiah/1976) | lassa virus Saphire, E.O., Hastie, K.M. 3.5 X-RAY DIFFRACTION 0.247 0.205 False True IGHV3 IGLV2 Lambda None None None None None 7la4 H L 0 A protein NA integrin alpha-iib CELL ADHESION 01/05/21 Integrin AlphaIIbBeta3-PT25-2 Complex MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Bush, M.W., Walz, T., Coller, B., Filizola, M., Spasic, A., Nesic, D., Li, J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV10 Kappa None None None None None 7chz H L 0 I protein NA interleukin-1 beta IMMUNOSUPPRESSANT 07/06/20 Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, C.C., Wang, A.H.J., Kuo, W.C. 2.5 X-RAY DIFFRACTION 0.260 0.193 False True IGHV3 IGKV1 Kappa None None None None None 6n1w Q R 0 c protein unknown VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 7zfe X NA 0 B protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV1 NA NA None None None None None 1d5b H L 0 IMMUNE SYSTEM 10/06/99 UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C. 2.8 X-RAY DIFFRACTION 0.285 0.232 False True IGHV1 IGKV14 Kappa None None None None None 7ws0 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6h06 E F 0 J peptide microtubule-associated protein tau IMMUNE SYSTEM 07/06/18 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Juraszek, J., Steinbacher, S. 2.63 X-RAY DIFFRACTION 0.270 0.216 False True IGHV1 IGKV2 Kappa 5.6e-06 -7.164753442850797 Unknown TBD 4cad K J 0 L protein ras and a-factor converting enzyme 1, rce1 PROTEIN BINDING 10/08/13 Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 METHANOCOCCUS MARIPALUDIS; MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis Kulkarni, K., Manolaridis, I., Dodd, R.B., Cronin, N., Ogasawara, S., Iwata, S., Barford, D. 2.5 X-RAY DIFFRACTION 0.2669 0.2262 False False IGHV1 IGKV12 Kappa None None None None None 1mcl NA A 0 P peptide n-acetyl-d-his-l-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 2orb I M 0 IMMUNE SYSTEM 02/02/07 The structure of the anti-c-myc antibody 9E10 Fab fragment MUS MUSCULUS mus musculus mus musculus Krauss, N., Scheerer, P., Hoehne, W. 2.2 X-RAY DIFFRACTION 0.317 0.261 False False IGHV5 IGKV3 Kappa None None None None None 7jxc H L 0 NA NA NA NA IMMUNE SYSTEM 08/27/20 Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology HOMO SAPIENS homo sapiens homo sapiens Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.47 X-RAY DIFFRACTION 0.226 0.187 False True IGHV3 IGLV6 Lambda None None None None None 7dm1 D C 0 A protein NA phosphate-binding protein psts 1 TRANSPROT PROTEIN/IMMUNE SYSTEM 12/01/20 crystal structure of the M.tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-36 MYCOBACTERIUM TUBERCULOSIS H37RV; HOMO SAPIENS homo sapiens homo sapiens mycobacterium tuberculosis h37rv Ma, B., Freund, N., Xiang, Y. 2.1 X-RAY DIFFRACTION 0.230 0.186 False True IGHV3 IGLV2 Lambda None None None None None 7ksg D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/22/20 SARS-CoV-2 spike in complex with nanobodies E SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS BACTRIANUS camelus bactrianus severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6ugs H L 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of PF06438179/GP1111 an infliximab biosimilar in a C-centered orthorhombic crystal form, Lot A HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H. 1.95 X-RAY DIFFRACTION 0.198 0.159 False True IGHV6 IGKV5 Kappa None None None None None 7r98 E NA 0 B protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/28/21 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody B6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Corbett, K.D., Ye, Q. 2.51 X-RAY DIFFRACTION 0.273 0.226 False True IGHV1 NA NA None None None None None 5e1a A B 0 C protein ph-gated potassium channel kcsa METAL TRANSPORT 09/29/15 Structure of KcsA with L24C/R117C mutations STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Upadhyay, V., Kim, D.M., Nimigean, C.M. 3.4 X-RAY DIFFRACTION 0.257 0.247 False False IGHV1 IGKV5 Kappa None None None None None 5l9d H L 0 L carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 06/10/16 AFAMIN ANTIBODY FRAGMENT, N14 FAB, L1- GLYCOSYLATED, CRYSTAL FORM I, parsimonious model MUS MUSCULUS mus musculus mus musculus mus musculus Rupp, B., Naschberger, A. 1.88 X-RAY DIFFRACTION 0.215 0.176 False False IGHV1 IGKV4 Kappa None None None None None 1jhl H L 0 A protein pheasant egg white lysozyme COMPLEX(ANTIBODY-ANTIGEN) 05/04/93 THREE-DIMENSIONAL STRUCTURE OF A HETEROCLITIC ANTIGEN-ANTIBODY CROSS-REACTION COMPLEX MUS MUSCULUS; PHASIANUS COLCHICUS mus musculus mus musculus phasianus colchicus Chitarra, V., Alzari, P.M., Bentley, G.A., Bhat, T.N., Eisele, J.-L., Poljak, R.J. 2.4 X-RAY DIFFRACTION unknown 0.214 False True IGHV1 IGKV16 Kappa None None None None None 7dzy O P 0 A protein NA spike glycoprotein VIRAL PROTEIN 01/26/21 Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 2490 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Y., Soh, W.T., Li, S., Kishikawa, J., Hirose, M., Kato, T., Standley, D., Okada, M., Arase, H. 3.6 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV3 IGKV3 Kappa None None None None None 4yzf G H 0 B protein band 3 anion transport protein IMMUNE SYSTEM 03/25/15 Crystal structure of the anion exchanger domain of human erythrocyte Band 3 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alguel, Y., Arakawa, T., Yugiri, T.K., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Suno, C.I., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A.D., Kobayashi, T., Hamasaki, N., Iwata, S. 3.5 X-RAY DIFFRACTION 0.290 0.274 False False IGHV8 IGKV3 Kappa None None None None None 7nxa A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the receptor binding domain of SARS-CoV-2 B.1.351 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.5 X-RAY DIFFRACTION 0.253 0.205 False True IGHV3 IGKV3 Kappa None None None None None 5bvj H G 0 IMMUNE SYSTEM 06/05/15 The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta HOMO SAPIENS homo sapiens homo sapiens Rondeau, J.M. 2.0 X-RAY DIFFRACTION 0.228 0.186 False True IGHV3 IGKV6 Kappa None None None None None 4cmh B C 0 A protein adp-ribosyl cyclase 1 HYDROLASE/IMMUNE SYSTEM 01/15/14 Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Deckert, J., Wetzel, M.C., Park, P.U., Bartle, L.M., Skaletskaya, A., Goldmacher, V., Vallee, F., ZhouLiu, Q., Ferrari, P., Pouzieux, S., Lahoute, C., Dumontet, C., Plesa, A., Chiron, M., Lejeune, P., Chittenden, T., Blanc, V. 1.53 X-RAY DIFFRACTION 0.2082 0.1878 False False IGHV1 IGKV6 Kappa 2.0000000000000003e-10 -13.231762501782761 Fluorescence TBD 6w0e A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Open-gate KcsA soaked in 10 mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 3.512 X-RAY DIFFRACTION 0.250 0.194 False True IGHV1 IGKV5 Kappa None None None None None 5jo5 A B 0 IMMUNE SYSTEM 05/02/16 Crystal structure of 10E8 gHV-gLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.263 0.233 False True IGHV3 IGLV3 Lambda None None None None None 2kqm NA B 8 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5vzx H L 0 IMMUNE SYSTEM 05/29/17 Crystal structure of crenezumab Fab HOMO SAPIENS homo sapiens homo sapiens Ultsch, M., Wang, W. 2.501 X-RAY DIFFRACTION 0.230 0.185 False True IGHV3 IGKV1 Kappa None None None None None 3h3b d D 0 B protein receptor tyrosine-protein kinase erbb-2 IMMUNE SYSTEM 04/16/09 Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Zhou, H., Liu, Y., Niu, L., Zhu, J., Teng, M. 2.45 X-RAY DIFFRACTION 0.255 0.201 True True unknown unknown unknown None None None None None 4lkc B A 0 IMMUNE SYSTEM 07/07/13 An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo HOMO SAPIENS homo sapiens homo sapiens Schiele, F., Nar, H. 2.2 X-RAY DIFFRACTION 0.245 0.172 False True IGHV3 IGKV1 Kappa None None None None None 5lsp H L 0 A protein hepatocyte growth factor receptor TRANSFERASE 09/05/16 107_A07 Fab in complex with fragment of the Met receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens DiCara, D., Chirgadze, D.Y., Pope, A., Karatt-Vellatt, A., Winter, A., van den Heuvel, J., Gherardi, E., McCafferty, J. 2.605 X-RAY DIFFRACTION 0.257 0.215 False True IGHV1 IGKV1 Kappa None None None None None 6ell H L 0 IMMUNE SYSTEM 09/29/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 1.9 X-RAY DIFFRACTION 0.245 0.203 False True IGHV4 IGKV1 Kappa None None None None None 1ynl H L 0 L Hapten NES 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID IMMUNE SYSTEM 01/24/05 Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeterners: Crystal structure of NC6.8 co-crystalized with high potency sweetener compound SC45647 MUS MUSCULUS mus musculus mus musculus mus musculus Gokulan, K., Khare, S., Ronning, D.R., Linthicum, S.D., Sacchettini, J.C., Rupp, B. 1.7 X-RAY DIFFRACTION 0.241 0.207 False True IGHV1 IGKV1 Kappa None None None None None 3g04 B A 0 C protein thyrotropin receptor IMMUNE SYSTEM 01/27/09 Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sanders, J., Chirgadze, D.Y., Sanders, P., Baker, S., Sullivan, A., Bhardwaja, A., Bolton, J., Reeve, M., Nakatake, N., Evans, M., Richards, T., Powell, M., Miguel, R.N., Blundell, T.L., Furmaniak, J., Smith, B.R. 2.55 X-RAY DIFFRACTION 0.245 0.181 False True IGHV5 IGLV1 Lambda None None None None None 7ue9 H L 0 C protein NA complement c3dg fragment IMMUNE SYSTEM 03/21/22 Structure of anti-C3d Fab(3d8b) in complex with C3d MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Olland, A.M., White, A., Suto, R.K. 1.75 X-RAY DIFFRACTION 0.201 0.171 False True IGHV1 IGKV2 Kappa None None None None None 7swd J K 0 A | C protein | protein NA | NA small/secreted glycoprotein | small/secreted glycoprotein VIRAL PROTEIN/Immune System 11/19/21 Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound ZAIRE EBOLAVIRUS (STRAIN GABON-94); ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus (strain gabon-94) | zaire ebolavirus (strain gabon-94) Milligan, J.C., Yu, X., Saphire, E.O. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 2pr4 H L 0 VIRAL PROTEIN 05/03/07 Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5 HOMO SAPIENS homo sapiens homo sapiens Bryson, S., Julien, J.-P., Pai, E.F. 2.05 X-RAY DIFFRACTION 0.270 0.240 False False IGHV2 IGKV1 Kappa None None None None None 6ni2 H L 0 B protein NA beta-arrestin-1 SIGNALING PROTEIN/IMMUNE SYSTEM 12/26/18 Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta-arrestin mega-complex LAMA GLAMA; BOS TAURUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct bos taurus Nguyen, A.H., Thomsen, A.R.B., Cahill, T.J., des Georges, A., Lefkowitz, R.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7te1 C F 0 E protein NA spike protein s1 IMMUNE SYSTEM/Viral Protein 01/03/22 SARS-CoV-2 Receptor Binding Domain in Complex with Ab17 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hauser, B.M., Schmidt, A.G. 3.5 X-RAY DIFFRACTION 0.344 0.297 False True IGHV1 IGKV14 Kappa None None None None None 2znx A a 0 Y protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 05/02/08 5-Fluorotryptophan Incorporated ScFv10 Complexed to Hen Egg Lysozyme MUS MUSCULUS; SYNTHETIC CONSTRUCT; GALLUS GALLUS mus musculus, synthetic construct gallus gallus DeSantis, M.E., Acchione, M., Li, M., Walter, R.L., Wlodawer, A., Smith-Gill, S. 2.3 X-RAY DIFFRACTION 0.232 0.193 True True unknown unknown unknown None None None None None 7s6k F G 0 E protein NA spike glycoprotein VIRAL PROTEIN/Immune System 09/14/21 J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5xaj A B 0 IMMUNE SYSTEM 03/13/17 Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex. DENGUE VIRUS dengue virus dengue virus Wong, Y.H., Goh, B.C., Lescar, J. 2.5 X-RAY DIFFRACTION 0.239 0.185 False True IGHV3 IGKV3 Kappa None None None None None 5mub I J 0 K peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 1ucb H L 0 IMMUNOGLOBULIN 02/06/96 STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ) HOMO SAPIENS homo sapiens homo sapiens Sheriff, S., Bajorath, J. 2.5 X-RAY DIFFRACTION 0.276 0.200 False True IGHV5 IGKV1 Kappa None None None None None 5ubz H L 0 IMMUNE SYSTEM 12/21/16 Fab structure of HIV gp120 specific mAb 1E12 HOMO SAPIENS homo sapiens homo sapiens Pan, R., Kong, X.-P. 2.75 X-RAY DIFFRACTION 0.264 0.189 False True IGHV4 IGLV1 Lambda None None None None None 2kqm NA A 18 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1mcf NA B 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-b-ala-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 5van B NA 0 A protein beta-klotho SIGNALING PROTEIN 03/27/17 Crystal Structure of Beta-Klotho HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Lee, S., Schlessinger, J. 2.202 X-RAY DIFFRACTION 0.211 0.186 False True IGHV1 None None None None None 5vm0 B NA 0 B Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/26/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T9 LAMA GLAMA lama glama lama glama Wogulis, L.A., Wogulis, M.D., Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.79 X-RAY DIFFRACTION 0.242 0.204 False True IGHV1 1.6000000000000003e-09 -11.99972732482342 Unknown TBD 6u8k F G 0 C nucleic-acid jiiiabc rna (68-mer) RNA/Immune System 09/05/19 Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepacivirus c Koirala, D., Lewicka, A., Koldobskaya, Y., Huang, H., Piccirilli, J.A. 2.75 X-RAY DIFFRACTION 0.222 0.186 False True IGHV3 IGKV1 Kappa None None None None None 7l57 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-15 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L. 5.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 4z7o H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 Membrane protein/Immune system 04/07/15 Integrin alphaIIbbeta3 in complex with AGDV peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Lin, F.Y., Zhu, J., Springer, T.A. 2.85 X-RAY DIFFRACTION 0.257 0.223 False True IGHV14 IGKV14 Kappa None None None None None 6y9b J N 0 B protein metalloreductase steap1 MEMBRANE PROTEIN 05/20/20 Cryo-EM structure of trimeric human STEAP1 bound to three Fab120.545 fragments HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Oosterheert, W., Gros, P. 2.97 ELECTRON MICROSCOPY False True IGHV3 IGKV8 Kappa None None None None None 6k68 C D 0 E protein protein a STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (8420-3MNZ) HUMAN IMMUNODEFICIENCY VIRUS 1; STAPHYLOCOCCUS AUREUS human immunodeficiency virus 1 human immunodeficiency virus 1 staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 3.2 X-RAY DIFFRACTION 0.318 0.289 False True IGHV9 IGKV8 Kappa None None None None None 6rlm K L 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 7ns6 H NA 0 J protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/05/21 SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4 vicugna pacos severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Das, H., Hallberg, B.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6mhg B O 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7mta H L 1 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1cly H L 0 H carbohydrate FUC polysaccharide IMMUNOGLOBULIN 03/15/95 IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sheriff, S., Bajorath, J. 2.5 X-RAY DIFFRACTION 0.298 0.238 False True IGHV5 IGKV1 Kappa None None None None None 7ksg E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/22/20 SARS-CoV-2 spike in complex with nanobodies E SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS BACTRIANUS camelus bactrianus severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5fhc H L 0 K protein envelope glycoprotein,envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/15 Crystal Structure of Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP) HOMO SAPIENS; ZAIRE EBOLAVIRUS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus Gilman, M.S.A., McLellan, J.S. 6.704 X-RAY DIFFRACTION 0.343 0.260 False True IGHV3 IGKV1 Kappa None None None None None 6s8i P O 0 C protein enveloped glycoprotein 1 VIRAL PROTEIN 07/10/19 Structure of ZEBOV GP in complex with 3T0265 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 2.99 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 3ikc B A 0 B Hapten KME (1E)-PROP-1-EN-1-YL 3-DEOXY-7-O-METHYL-ALPHA-D-MANNO-OCT-2-ULOPYRANOSIDONIC ACID IMMUNE SYSTEM 08/05/09 Structure of S67-27 in Complex with Kdo(2.8)-7-O-methyl-Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.6 X-RAY DIFFRACTION 0.291 0.235 False False IGHV7 IGKV8 Kappa 3.5e-08 -10.171711101540176 Unknown TBD 6ni2 A NA 0 B | V protein | peptide NA | NA beta-arrestin-1 | vasopressin v2 receptor SIGNALING PROTEIN/IMMUNE SYSTEM 12/26/18 Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta-arrestin mega-complex LAMA GLAMA; BOS TAURUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama bos taurus | homo sapiens Nguyen, A.H., Thomsen, A.R.B., Cahill, T.J., des Georges, A., Lefkowitz, R.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5euk D C 0 IMMUNE SYSTEM 11/18/15 Cetuximab Fab in complex with F3H meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.5 X-RAY DIFFRACTION 0.234 0.171 False True IGHV2 IGKV5 Kappa None None None None None 7k43 F G 0 E protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/14/20 SARS-CoV-2 spike in complex with the S2M11 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5o2u D NA 0 C protein capsid protein p24 VIRUS 05/22/17 Llama VHH in complex with p24 LAMA GLAMA; HUMAN IMMUNODEFICIENCY VIRUS 1 lama glama human immunodeficiency virus 1 Caillat, C., Verrips, T., Weissenhorn, W. 2.76 X-RAY DIFFRACTION 0.256 0.222 False True IGHV1 6.9e-10 -12.498045980157077 SPR TBD 4s1r H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 01/14/15 Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D. 3.214 X-RAY DIFFRACTION 0.286 0.261 False True unknown IGKV3 Kappa None None None None None 7t5f B NA 0 A protein NA botulinum neurotoxin type b TOXIN 12/12/21 Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10 CLOSTRIDIUM BOTULINUM; CAMELIDAE camelidae clostridium botulinum Jin, R., Lam, K.-H. 2.6 X-RAY DIFFRACTION 0.222 0.194 False True IGHV3 NA NA None None None None None 5vcn F E 0 A protein peptidase 1 IMMUNE SYSTEM 03/31/17 THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 5H8 MUS MUSCULUS; DERMATOPHAGOIDES PTERONYSSINUS mus musculus mus musculus dermatophagoides pteronyssinus Osinski, T., Majorek, K.A., Pomes, A., Offermann, L.R., Osinski, S., Glesner, J., Vailes, L.D., Chapman, M.D., Minor, W., Chruszcz, M. 3.0 X-RAY DIFFRACTION 0.265 0.219 False True IGHV2 IGKV10 Kappa None None None None None 6e1k D C 0 B protein two pore calcium channel protein 1 MEMBRANE PROTEIN 07/10/18 Structure of AtTPC1(DDE) reconstituted in saposin A with cat06 Fab ARABIDOPSIS THALIANA; HOMO SAPIENS homo sapiens homo sapiens arabidopsis thaliana Kintzer, A.F., Green, E.M., Cheng, Y., Stroud, R.M. 3.3 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 1bz7 B A 0 IMMUNE SYSTEM 11/06/98 FAB FRAGMENT FROM MURINE ASCITES MUS MUSCULUS mus musculus mus musculus Kaminski, M.J., Mackenzie, C.R., Mooibroek, M.J., Dahms, T.E.S., Hirama, T., Houghton, A.N., Chapman, P.B., Evans, S.V. 2.5 X-RAY DIFFRACTION unknown 0.162 False False IGHV5 IGKV10 Kappa None None None None None 6att H L 0 A protein receptor tyrosine-protein kinase erbb-2 IMMUNE SYSTEM 08/29/17 39S Fab bound to HER2 ecd HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., Dall'Acqua, W.F. 3.77 X-RAY DIFFRACTION 0.289 0.251 False True IGHV3 IGKV2 Kappa None None None None None 6dde E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/10/18 Mu Opioid Receptor-Gi Protein Complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Koehl, A., Hu, H., Maeda, S., Manglik, A., Zhang, Y., Kobilka, B.K., Skiniotis, G., Weis, W.I. 3.5 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6mzj H L 0 A protein 426c ds-sosip d3 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/18 Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 2 Fabs bound, sharpened map HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Borst, A.J., Weidle, C.E., Gray, M.D., Frenz, B., Snijder, J., Joyce, M.G., Georgiev, I.S., Stewart-Jones, G.B.E., Kwong, P.D., McGuire, A.T., DiMaio, F., Stamatatos, L., Pancera, M., Veesler, D. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6e5p 3 4 0 E protein envelope glycoprotein gp120 VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 6usf H L 0 D protein chimera of soluble cytochrome b562 (bril) and neuronalacetylcholine receptor subunit alpha-4 MEMBRANE PROTEIN/IMMUNE SYSTEM 10/26/19 CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens homo sapiens homo sapiens, escherichia coli Alvarez, F.J.D., Mukherjee, S., Han, S., Ammirati, M., Kossiakoff, A.A. 3.87 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6ey6 K NA 0 C protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 6oo0 H L 0 IMMUNE SYSTEM 04/01/20 Crystal structure of bovine Fab NC-Cow1 BOS TAURUS bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.238 0.202 False True unknown IGLV1 Lambda None None None None None 5njd T S 0 G | F protein | protein NA | NA interleukin-12 subunit beta | interleukin-23 subunit alpha IMMUNE SYSTEM 03/28/17 Structure of Interleukin 23 in complex with Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Bloch, Y., Savvides, S.N. 3.9 X-RAY DIFFRACTION 0.312 0.272 False True IGHV3 IGLV1 Lambda None None None None None 7q9p E F 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-06 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 5nml F NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 1q9w D C 0 C carbohydrate KDO polysaccharide IMMUNE SYSTEM 08/26/03 S45-18 Fab pentasaccharide bisphosphate complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Nguyen, H.P., Seto, N.O., MacKenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.75 X-RAY DIFFRACTION 0.247 0.212 False False IGHV7 IGKV8 Kappa None None None None None 5b3n A a 0 IMMUNE SYSTEM 03/04/16 The crystal structure of anti-H4K20me1_scFv, 15F11 SYNTHETIC CONSTRUCT synthetic construct Kujirai, T., Horikoshi, N., Kurumizaka, H. 1.94 X-RAY DIFFRACTION 0.244 0.203 True True unknown unknown unknown None None None None None 7qn7 G NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 HOMO SAPIENS homo sapiens homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7khf H B 0 I carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/21/20 CryoEM structure of LILRB1 D3D4 domain-inserted antibody MDB1 Fab in complex with Plasmodium RIFIN (PF3D7_1373400) V2 domain HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens Xu, K., Kwong, P.D. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV3 Lambda None None None None None 3if1 D C 0 IMMUNE SYSTEM 07/23/09 Crystal structure of 237mAb in complex with a GalNAc MUS MUSCULUS mus musculus mus musculus Brooks, C.L., Evans, S.V., Borisova, S.N. 2.39 X-RAY DIFFRACTION 0.285 0.224 False True IGHV6 IGKV1 Kappa None None None None None 6xjq H L 0 A nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - alkylated form with biotinylated epoxide substrate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 1.708 X-RAY DIFFRACTION 0.213 0.189 False True IGHV3 IGKV1 Kappa None None None None None 7rqp A B 0 NA NA NA NA IMMUNE SYSTEM 08/06/21 Structure of PfCSP NPNV binding antibody L9 HOMO SAPIENS homo sapiens homo sapiens Hurlburt, N.K., Pancera, M. 2.98 X-RAY DIFFRACTION 0.250 0.199 False True IGHV3 IGKV1 Kappa None None None None None 4kka C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 20mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.0 X-RAY DIFFRACTION 0.265 0.220 False True IGHV4 IGKV4 Kappa None None None None None 6o41 B A 0 N protein immunoglobulin g-binding protein g (domain iii) IMMUNE SYSTEM 02/27/19 Crystal structure of the unbound PGZL1 germline Fab fragment (PGZL1_gVmDmJ) HOMO SAPIENS; STREPTOCOCCUS SP. GROUP G homo sapiens homo sapiens streptococcus sp. group g Irimia, A., Wilson, I.A. 2.465 X-RAY DIFFRACTION 0.219 0.169 False True IGHV1 IGKV3 Kappa None None None None None 7c01 H L 0 A protein sars-cov-2 spike protein s1 VIRAL PROTEIN 05/27/20 Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shi, R., Qi, J., Wang, Q., Gao, F.G., Yan, J. 2.88 X-RAY DIFFRACTION 0.265 0.218 False True IGHV3 IGKV1 Kappa None None None None None 3cm9 C N 1 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6ssp L NA 0 H | G | F | I | J protein | protein | protein | protein | protein NA | NA | NA | NA | NA cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel TRANSPORT PROTEIN 09/09/19 Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi | dickeya chrysanthemi | dickeya chrysanthemi | dickeya chrysanthemi | dickeya chrysanthemi Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J. 3.25 X-RAY DIFFRACTION 0.264 0.248 False True IGHV1 NA NA None None None None None 1ol0 B NA 0 IMMUNOGLOBULIN 08/02/03 Crystal structure of a camelised human VH HOMO SAPIENS homo sapiens Dottorini, T., K Vaughan, C., Walsh, M.A., Losurdo, P., Sollazzo, M. 1.8 X-RAY DIFFRACTION 0.18015 0.15449 False True IGHV3 None None None None None 3sob H L 0 B protein low-density lipoprotein receptor-related protein 6 PROTEIN BINDING/IMMUNE SYSTEM 06/30/11 The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, W., Bourhis, E., Tam, C., Zhang, Y., Rouge, L., Wu, Y., Franke, Y., Cochran, A.G. 1.9 X-RAY DIFFRACTION 0.212 0.174 False True IGHV3 IGKV1 Kappa None None None None None 6pci I L 0 B protein NA virion spike glycoprotein immune system, viral protein 06/17/19 EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus Ward, A.B., Murin, C.D., Alkutkar, T. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7jwp K L 0 V peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 6o3l A B 0 E peptide mper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41). HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 1.98 X-RAY DIFFRACTION 0.211 0.170 False True IGHV1 IGKV3 Kappa None None None None None 2old NA B 0 IMMUNE SYSTEM 01/19/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(2)21 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.6 X-RAY DIFFRACTION 0.254 0.215 False False IGLV2 Lambda None None None None None 7cwt I J 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike protein in complex with hb27 and fc05 Fab cocktail SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cui, Z., Wang, X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 5aaw K k 0 L protein dengue serotype 4 envelope protein domain 3 07/30/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency DENGUE VIRUS; MUS MUSCULUS mus musculus dengue virus Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R. 3.27 X-RAY DIFFRACTION 0.26258 0.22661 True True unknown unknown unknown 4.320000000000001e-09 -11.411241859183763 SPR TBD 7kkl E NA 0 C protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/20 SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 2.85 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3eoa H L 0 I protein integrin alpha-l IMMUNE SYSTEM/CELL ADHESION 09/26/08 Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, S., Ding, J. 2.8 X-RAY DIFFRACTION 0.264 0.225 False True IGHV3 IGKV1 Kappa 2.20e-09 -11.8 SPR 25 19258452 5vh3 A B 0 IMMUNE SYSTEM 04/12/17 Crystal structure of Fab fragment of the anti-TNFa antibody infliximab in a C-centered orthorhombic crystal form MUS MUSCULUS mus musculus mus musculus Mayclin, S.J., Edwards, T.E., Lerch, T.F., Conlan, H., Sharpe, P. 2.0 X-RAY DIFFRACTION 0.200 0.160 False True IGHV6 IGKV5 Kappa None None None None None 7eh5 E P 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/28/21 Cryo-EM structure of SARS-CoV-2 S-D614G variant in complex with neutralizing antibodies, RBD-chAb15 and RBD-chAb45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Chang, Y.C., Wu, H.C., Hsu, S.T.D. 4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV5 Kappa None None None None None 7eh3 A NA 0 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7mdt H L 0 A protein NA surface protein gp120 VIRAL PROTEIN 04/06/21 BG505 SOSIP.v5.2 in complex with the monoclonal antibody Rh4O9.8 (as Fab fragment) HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Antanasijevic, A., Ozorowski, G., Nogal, B., Ward, A.B. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 4q6i H L 0 C protein t-cell surface glycoprotein cd4 IMMUNE SYSTEM 04/22/14 Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Boyington, J.C., Nabel, G.J., Mascola, J.R. 3.65 X-RAY DIFFRACTION 0.257 0.226 False False IGHV9 IGKV3 Kappa None None None None None 6x07 B NA 0 A protein NA nucleoporin nic96 STRUCTURAL PROTEIN 05/15/20 Nic96 from S. cerevisiae bound by VHH-SAN12 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Andersen, K., Nordeen, S.A., Schwartz, T.U. 2.1 X-RAY DIFFRACTION 0.245 0.227 False True IGHV1 NA NA None None None None None 4fze H L 0 IMMUNE SYSTEM 07/06/12 Crystal structure of N26_i1 Fab, an ADCC mediating anti-HIV-1 antibody. HOMO SAPIENS homo sapiens homo sapiens Tolbert, W.D., Wu, X., Pazgier, M. 1.999 X-RAY DIFFRACTION 0.245 0.186 False True IGHV1 IGLV3 Lambda None None None None None 3nps B C 0 A protein suppressor of tumorigenicity 14 protein HYDROLASE/IMMUNE SYSTEM 06/29/10 Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Baharuddin, A. 1.5 X-RAY DIFFRACTION 0.228 0.188 False True IGHV1 IGLV1 Lambda None None None None None 7e9g E NA 0 R protein NA metabotropic glutamate receptor 2 MEMBRANE PROTEIN 03/04/21 Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Lin, S., Han, S., Zhao, Q., Wu, B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5dd5 H L 0 IMMUNE SYSTEM 08/24/15 Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I., Pemble IV, C.W., Haynes, B.F. 1.9 X-RAY DIFFRACTION 0.261 0.198 False True IGHV4 IGKV1 Kappa None None None None None 7l8p E F 0 C protein NA isoform 3 of integrin alpha-iib CELL ADHESION 12/31/20 Integrin alphaIIbbeta3 in complex with sibrafiban HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lin, F.-Y., Springer, T.A. 2.34995 X-RAY DIFFRACTION 0.245 0.204 False True IGHV14 IGKV14 Kappa None None None None None 2kqn NA B 4 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7oo2 C D 0 NA NA NA NA ANTIMICROBIAL PROTEIN 05/26/21 Crystal structure of an antibody targeting the capsular polysaccharide of serogroup X Neisseria meningitidis (MenX) MUS MUSCULUS mus musculus mus musculus Pietri, G.P., de Ruyck, J., Lenac, T., Adamo, R., Bouckaert, J. 2.16 X-RAY DIFFRACTION 0.262 0.213 False True IGHV2 IGKV17 Kappa None None None None None 7ndf C NA 0 B protein NA lipid a abc transporter atp-binding protein/permease msba PROTEIN BINDING 02/01/21 Crystal structure of nanobody Nb_MsbA#1 in complex with the nucleotide binding domain of MsbA VICUGNA PACOS; ESCHERICHIA COLI vicugna pacos escherichia coli Meier, G., Seeger, M. 2.1 X-RAY DIFFRACTION 0.244 0.205 False True IGHV1 NA NA None None None None None 1s78 F E 0 B protein receptor protein-tyrosine kinase erbb-2 TRANSFERASE 01/29/04 Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Franklin, M.C., Carey, K.D., Vajdos, F.F., Leahy, D.J., de Vos, A.M., Sliwkowski, M.X. 3.25 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV1 Kappa None None None None None 6fyu I NA 0 H | G protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/12/18 Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36 INFLUENZA A VIRUS; LAMA GLAMA lama glama influenza a virus | influenza a virus Laursen, N.S., Wilson, I.A. 2.643 X-RAY DIFFRACTION 0.216 0.186 False True IGHV1 NA NA None None None None None 6edu L M 0 D | I protein | protein NA | NA envelope glycoprotein gp160 | t-cell surface glycoprotein cd4 IMMUNE SYSTEM 08/11/18 B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | homo sapiens Barnes, C.O., Bjorkman, P.J. 4.06 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 5yd4 G g 0 H peptide epitope peptide (mutation t6a) IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide (mutation T6A) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.173 0.135 True True unknown unknown unknown None None None None None 6k64 NA A 0 C protein protein a STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (8188-3LRH) HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS homo sapiens staphylococcus aureus subsp. aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.933 X-RAY DIFFRACTION 0.207 0.171 False True IGLV1 Lambda None None None None None 6b7z E F 0 B protein insulin-degrading enzyme HYDROLASE/IMMUNE SYSTEM 10/05/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 6.5 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 7ter M N 0 D | C protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 non-active2 conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 5.23 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 7f35 F E 0 E Hapten GFN 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid IMMUNE SYSTEM 06/15/21 Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with S-gatifloxacin MUS MUSCULUS mus musculus mus musculus mus musculus Wang, L.T., Jiao, W.Y., Shen, X., Lei, H.T. 2.6 X-RAY DIFFRACTION 0.235 0.200 False False IGHV1 IGKV3 Kappa None None None None None 4m1g H L 0 B | A protein | protein NA | NA a33r | a33r IMMUNE SYSTEM 08/02/13 Structure of murine IgG2a A27D7-Fab in complex with vaccinia antigen A33R at the resolution of 1.6 Angstroms MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus | vaccinia virus Matho, M.H., Schlossman, A.M., Zajonc, D.M. 1.6 X-RAY DIFFRACTION 0.226 0.201 False True IGHV2 IGKV4 Kappa 1.4400000000000002e-08 -10.697907621456812 SPR TBD 6qgy B NA 0 A protein outer membrane protein assembly factor bama MEMBRANE PROTEIN 01/14/19 Crystal structure of E.coli BamA beta-barrel in complex with nanobody B12 ESCHERICHIA COLI O157:H7; LAMA GLAMA lama glama escherichia coli o157 Hartmann, J.-B., Kaur, H., Jakob, R.P., Zahn, M., Zimmermann, I., Seeger, M., Maier, T., Hiller, S. 2.509 X-RAY DIFFRACTION 0.244 0.222 False True IGHV1 None None None None None 5aum A B 0 D peptide peptide renlyfqgkdg IMMUNE SYSTEM/PEPTIDE 04/30/15 Crystal structure of a Fab fragment with the ligand peptide RATTUS; SYNTHETIC CONSTRUCT rattus rattus potyviridae Kitago, Y., Takagi, J. 2.05 X-RAY DIFFRACTION 0.221 0.189 False True IGHV10 IGKV2 Kappa None None None None None 6kyz B C 0 A protein genome polyprotein VIRAL PROTEIN 05/27/20 HRV14 3C in complex with single chain antibody YDF HUMAN RHINOVIRUS 14; HOMO SAPIENS homo sapiens homo sapiens human rhinovirus 14 Meng, B., Yang, B., Wilson, I.A. 1.845 X-RAY DIFFRACTION 0.208 0.175 False True IGHV3 IGLV3 Lambda None None None None None 4hij B A 0 B carbohydrate RAM polysaccharide IMMUNE SYSTEM 10/11/12 Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound L-rhamnose-(1-2)-alpha-D-galactose-(3-O)-phosphate-2-glycerol HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Schrader, J.W., Pai, E.F. 2.1 X-RAY DIFFRACTION 0.262 0.249 False True IGHV3 IGKV3 Kappa None None None None None 7jn5 H L 0 F protein NA spike glycoprotein Viral protein/IMMUNE SYSTEM 08/03/20 Crystal structure of SARS-CoV receptor binding domain in complex with human antibody CR3022 HOMO SAPIENS; HUMAN SARS CORONAVIRUS homo sapiens homo sapiens human sars coronavirus Wu, N.C., Yuan, M., Zhu, X., Wilson, I.A. 2.705 X-RAY DIFFRACTION 0.272 0.211 False True IGHV5 IGKV4 Kappa None None None None None 7zxu A NA 0 E protein NA spike protein s1 VIRAL PROTEIN 05/23/22 SARS-CoV-2 Omicron BA.4/5 RBD in complex with Beta-27 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 lama glama severe acute respiratory syndrome coronavirus2 Huo, J., Zhou, D., Ren, J., Stuart, D.I. 1.89 X-RAY DIFFRACTION 0.209 0.181 False True IGHV1 NA NA None None None None None 7qf1 C B 0 A protein NA spike protein s1 VIRAL PROTEIN 12/03/21 Crystal structure of the SARS-CoV-2 RBD in complex with the human antibody CV2.6264 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fernandez, I., Pederzoli, R., Rey, F.A. 2.8 X-RAY DIFFRACTION 0.254 0.229 False True IGHV1 IGKV1 Kappa None None None None None 6rnk B NA 0 A protein succinate receptor 1 MEMBRANE PROTEIN 05/08/19 Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist NF-56-EJ40. RATTUS NORVEGICUS; VICUGNA PACOS vicugna pacos rattus norvegicus Haffke, M., Jaakola, V.-P. 1.94 X-RAY DIFFRACTION 0.199 0.177 False True IGHV1 None None None None None 5wym A a 0 IMMUNE SYSTEM 01/13/17 Crystal structure of an anti-connexin26 scFv HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens, synthetic construct Li, S., Xu, L. 2.65 X-RAY DIFFRACTION 0.263 0.236 True True unknown unknown unknown None None None None None 2vdo H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide, HHLGGAKQAGDV HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.51 X-RAY DIFFRACTION 0.190 0.148 False False IGHV14 IGKV14 Kappa None None None None None 6ssi H NA 0 C protein cys-loop ligand-gated ion channel TRANSPORT PROTEIN 09/07/19 Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J. 2.59 X-RAY DIFFRACTION 0.246 0.230 False True IGHV1 None None None None None 6mu3 H L 0 H carbohydrate BMA polysaccharide IMMUNE SYSTEM 10/22/18 Anti-HIV-1 Fab 2G12 + Man7 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wilson, I.A., Calarese, D.A., Stanfield, R.L. 2.327 X-RAY DIFFRACTION 0.235 0.201 False True unknown IGKV1 Kappa 7e-07 -8.39678861981014 Unknown TBD 5uk4 m NA 0 M protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 6k2i A NA 19 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7oay L NA 0 K protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 2.34 X-RAY DIFFRACTION 0.228 0.192 False False IGHV1 NA NA None None None None None 6by3 A B 0 C protein ph-gated potassium channel kcsa MEMBRANE PROTEIN 12/19/17 Open and conductive conformation of KcsA-T75A mutant MUS MUSCULUS; STREPTOMYCES COELICOLOR mus musculus mus musculus streptomyces coelicolor Labro, A.J., Cortes, D.M., Tilegenova, C., Cuello, L.G. 2.37 X-RAY DIFFRACTION 0.219 0.205 False True IGHV1 IGKV5 Kappa None None None None None 4xi5 D C 0 B | A protein | protein NA | NA envelope glycoprotein l | envelope glycoprotein h Viral Protein/Immune System 01/06/15 gHgL of varicella-zoster virus in complex with human neutralizing antibodies HUMAN HERPESVIRUS 3 STRAIN OKA VACCINE; HOMO SAPIENS homo sapiens homo sapiens human herpesvirus 3 strain oka vaccine | human herpesvirus 3 strain oka vaccine Xing, Y. 3.9 X-RAY DIFFRACTION 0.276 0.245 False True IGHV3 IGKV1 Kappa 4.900000000000001e-10 -12.700844971389516 SPR TBD 7mzk F E 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 96 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.25 X-RAY DIFFRACTION 0.235 0.197 False True IGHV3 IGLV1 Lambda None None None None None 7nj3 F NA 0 A protein NA polymerase acidic protein VIRAL PROTEIN 02/15/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (strain a/brevigmission/1/1918 h1n1) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.48 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5k9o H L 0 I protein hemagglutinin IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 31.b.09 in complex with Hemagglutinin H1 A/California/04/2009. INFLUENZA A VIRUS (STRAIN SWL A/CALIFORNIA/04/2009 H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain swla/california/04/2009 h1n1) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 3.387 X-RAY DIFFRACTION 0.346 0.291 False True IGHV1 IGKV2 Kappa None None None None None 3iy3 B A 0 IMMUNE SYSTEM 04/09/09 Variable domains of the computer generated model (WAM) of Fab 8 fitted into the cryoEM reconstruction of the virus-Fab 8 complex MUS MUSCULUS mus musculus mus musculus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Chipman, P.R., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 11.1 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 3rpi H L 0 IMMUNE SYSTEM 04/26/11 Crystal Structure of Fab from 3BNC60, Highly Potent anti-HIV Antibody HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Bjorkman, P.J. 2.648 X-RAY DIFFRACTION 0.258 0.208 False True IGHV1 IGKV1 Kappa None None None None None 7zr7 D E 0 A protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/03/22 OMI-42 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; TEQUATROVIRUS T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6e9q C D 0 IMMUNE SYSTEM 05/01/19 The crystal structure of bovine ultralong antibody BOV-6 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.4 X-RAY DIFFRACTION 0.311 0.254 False True IGHV1 IGLV1 Lambda None None None None None 4n1e NA C 0 J protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 5vj6 Q R 0 C | F protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/18/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 11.5 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5ukb e NA 0 E protein nucleocapsid Viral Protein/RNA/Immune System 01/20/17 VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 ESCHERICHIA COLI; VESICULAR STOMATITIS INDIANA VIRUS; VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 5.473 X-RAY DIFFRACTION 0.338 0.336 False False IGHV1 None None None None None 1vhp A NA 8 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7wpe X Y 0 B protein NA spike glycoprotein VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with two JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5dwu H L 0 A | B protein | protein NA | NA cytokine receptor common subunit beta | cytokine receptor common subunit beta IMMUNE SYSTEM 09/23/15 Beta common receptor in complex with a Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Dhagat, U., Parker, M.W. 3.97 X-RAY DIFFRACTION 0.330 0.289 False True IGHV3 IGKV1 Kappa 4.9e-08 -9.972356792569007 SPR TBD 3n85 H L 0 A protein receptor tyrosine-protein kinase erbb-2 Transferase/immune system 05/27/10 Crystallographic trimer of HER2 extracellular regions in complex with tryptophan-rich antibody fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C. 3.2 X-RAY DIFFRACTION 0.230 0.206 False True IGHV3 IGKV1 Kappa 7.90e-10 -12.41 SPR 20654626 3uaj C D 0 B protein envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 10/21/11 Crystal structure of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 DENGUE VIRUS 4; PAN TROGLODYTES pan troglodytes pan troglodytes dengue virus 4 Cockburn, J.J.B., Stura, E.A., Navarro-Sanchez, M.E., Rey, F.A. 3.232 X-RAY DIFFRACTION 0.246 0.241 False True IGHV4 IGKV1 Kappa 2.9e-09 -11.647373069103503 Unknown TBD 2ltq C B 2 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 5y9c H L 0 D | A | C | E protein | protein | protein | protein NA | NA | NA | NA major capsid protein l1 | major capsid protein l1 | major capsid protein l1 | major capsid protein l1 STRUCTURAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV58 pentamer in complex with the Fab fragment of antibody A12A3 HUMAN PAPILLOMAVIRUS TYPE 58; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 58 | human papillomavirus type 58 | human papillomavirus type 58 | human papillomavirus type 58 Li, S.W., Li, Z.H. 3.443 X-RAY DIFFRACTION 0.249 0.202 False False IGHV14 IGKV19 Kappa None None None None None 6snc B A 0 C peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.2 X-RAY DIFFRACTION 0.254 0.213 False True IGHV4 IGKV1 Kappa None None None None None 4xnz H L 0 G protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 01/16/15 Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 3.389 X-RAY DIFFRACTION 0.301 0.244 False True unknown unknown unknown None None None None None 3tv3 H L 0 A carbohydrate MAN ALPHA-D-MANNOSE IMMUNE SYSTEM 09/19/11 Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with Man9 HOMO SAPIENS homo sapiens homo sapiens Pejchal, R., Wilson, I.A. 1.29 X-RAY DIFFRACTION 0.184 0.159 False True IGHV4 IGLV2 Lambda None None None None None 6nms H L 0 S protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Blocking Fab 136 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.11 X-RAY DIFFRACTION 0.244 0.204 False True IGHV3 IGKV3 Kappa None None None None None 7sfx J K 0 NA NA NA NA IMMUNE SYSTEM 10/04/21 10A1 Fab in complex with CD99 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Romero, L.A., Hattori, T., Koide, S. 3.1 X-RAY DIFFRACTION 0.248 0.226 False True IGHV6 IGLV3 Lambda None None None None None 5d9q D d 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 08/18/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Ward, A.B., Wilson, I.A. 4.4 X-RAY DIFFRACTION 0.320 0.290 True True unknown unknown unknown None None None None None 4evn K L 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 7l06 H L 0 U carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 12/11/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Manne, K., Henderson, R., Acharya, P. 3.3 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7p6k G NA 0 B protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/16/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb5 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6x3v J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 5vl3 H L 0 Q protein b-cell receptor cd22 IMMUNE SYSTEM 04/24/17 CD22 d1-d3 in complex with therapeutic Fab Epratuzumab HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Sicard, T., Ereno-Orbea, J., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.295 0.280 False True IGHV1 IGKV8 Kappa None None None None None 5i5k X Y 0 A protein complement c5 IMMUNE SYSTEM 02/15/16 Structure of complement C5 in complex with eculizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schatz-Jakobsen, J.A., Andersen, G.R. 4.2 X-RAY DIFFRACTION 0.244 0.205 False True IGHV1 IGKV1 Kappa 1.7600000000000003e-11 -14.671745777572001 SPR TBD 3u79 NA A 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 7lvu D NA 0 NA NA NA NA IMMUNE SYSTEM 02/26/21 Structure of RSV F-directed VHH Cl184 LAMA GLAMA lama glama Hsieh, C.-L., McLellan, J.S. 1.94 X-RAY DIFFRACTION 0.233 0.208 False True IGHV1 NA NA None None None None None 7rdm B A 0 C carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 07/09/21 Crystal structure of PCDN-38B, a broadly neutralizing anti-HIV antibody HOMO SAPIENS homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 2.08 X-RAY DIFFRACTION 0.219 0.191 False True IGHV4 IGKV3 Kappa None None None None None 7mlu N O 0 D protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7s8g H L 0 NA NA NA NA ANTIVIRAL PROTEIN,IMMUNE SYSTEM 09/17/21 Structure of anti-LASV Fab 25.10C with FNQI mutation HOMO SAPIENS homo sapiens homo sapiens Hastie, K.M., Enriquez, A.S. 2.57 X-RAY DIFFRACTION 0.263 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7n9c E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/17/21 Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB95 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Sun, D., Zhang, C., Shi, Y. 3.71 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2nyy D C 0 A protein botulinum neurotoxin type a TOXIN/IMMUNE SYSTEM 11/21/06 Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody CR1 HOMO SAPIENS; CLOSTRIDIUM BOTULINUM clostridium botulinum Stevens, R.C., Arndt, J.W. 2.61 X-RAY DIFFRACTION 0.246 0.206 False False IGHV5 IGKV3 Kappa 2.48e-12 -15.72 Other 23 17173035 6dca J N 0 R peptide microtubule-associated protein tau IMMUNE SYSTEM 05/04/18 Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 2.599 X-RAY DIFFRACTION 0.259 0.189 False False IGHV1 IGKV1 Kappa None None None None None 7dk4 a b 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/23/20 S-2H2-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 5cus K O 0 D protein receptor tyrosine-protein kinase erbb-3 TRANSFERASE 07/25/15 Crystal Structure of sErbB3-Fab3379 Complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, S., Schlessinger, J. 3.2 X-RAY DIFFRACTION 0.278 0.252 False True IGHV3 IGLV1 Lambda None None None None None 6m2r H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 02/28/20 X-ray structure of a functional Drosophila dopamine transporter in L-norepinephrine bound form DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Shabareesh, P., Mallela, A.K., Joseph, D., Penmatsa, A. 2.802 X-RAY DIFFRACTION 0.247 0.211 False True IGHV5 IGKV4 Kappa None None None None None 7nik F NA 0 A | B protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit VIRAL PROTEIN 02/12/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (strain a/brevigmission/1/1918 h1n1) | influenza a virus (strain a/brevigmission/1/1918 h1n1) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 6.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3auv F f 0 IMMUNE SYSTEM 02/16/11 Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface HOMO SAPIENS homo sapiens Yu, C.M., Peng, H.P., Chen, I.C., Lee, Y.C., Chen, J.B., Tsai, K.C., Chen, C.T., Chang, J.Y., Yang, E.W., Hsu, P.C., Jian, J.W., Hsu, H.J., Chang, H.J., Hsu, W.L., Huang, K.F., Ma, A.C., Yang, A.S. 2.4 X-RAY DIFFRACTION 0.251 0.216 True True unknown unknown unknown None None None None None 7r23 C NA 0 A protein NA arc STRUCTURAL PROTEIN 02/04/22 Crystal structure of human Arc CTD in complex with two anti-Arc nanobodies HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Markusson, S., Kursula, P. 2.77 X-RAY DIFFRACTION 0.302 0.252 False True IGHV1 NA NA None None None None None 3eo1 H G 0 I protein transforming growth factor beta-3 IMMUNE SYSTEM/CYTOKINE 09/26/08 Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Gruetter, C., Gruetter, M.G. 3.1 X-RAY DIFFRACTION 0.279 0.255 False True IGHV1 IGKV8 Kappa 2.50e-10 -13.09 Other 19073914 7pnm I E 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/07/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 46C12 antibody Fab fragment HUMAN CORONAVIRUS OC43; HOMO SAPIENS homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 1rzk H L 0 G protein envelope glycoprotein gp120 Viral protein/Immune system 12/24/03 HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.297 0.205 False True IGHV1 IGKV3 Kappa None None None None None 7zfb M NA 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.08 X-RAY DIFFRACTION 0.308 0.261 False True IGHV1 NA NA None None None None None 7shy C D 0 A protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with omalizumab scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.230 0.173 False True IGHV3 IGKV1 Kappa None None None None None 3ujt H L 0 IMMUNE SYSTEM 11/08/11 Structure of the Fab fragment of Ab-52, an antibody that binds the O-antigen of Francisella tularensis MUS MUSCULUS mus musculus mus musculus Rynkiewicz, M.J., Lu, Z., Hui, J.H., Sharon, J., Seaton, B.A. 2.1 X-RAY DIFFRACTION 0.220 0.186 False False IGHV1 IGKV8 Kappa None None None None None 7dk0 A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/22/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW05 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M. 3.199 X-RAY DIFFRACTION 0.265 0.218 False True IGHV1 IGKV3 Kappa None None None None None 15c8 H L 0 CATALYTIC ANTIBODY 03/18/98 CATALYTIC ANTIBODY 5C8, FREE FAB MUS MUSCULUS mus musculus mus musculus Gruber, K., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.251 0.190 False False IGHV14 IGKV4 Kappa None None None None None 7amq H L 0 B protein NA human a6 t-cell receptor beta chain trbc1 IMMUNE SYSTEM 10/09/20 Crystal structure of the complex of HuJovi-1 Fab with the human TRBC2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferrari, M., Bulek, A., Bughda, R., Jha, R., Welin, M., Logan, D.T., Sewell, A., Onuoha, S., Pule, M. 2.353 X-RAY DIFFRACTION 0.249 0.201 False True IGHV1 IGKV1 Kappa None None None None None 5boz I NA 0 C protein ricin Hydrolase/Immune system 05/27/15 Ricin A chain bound to camelid nanobody (VHH9)(E1) RICINUS COMMUNIS; LAMA GLAMA lama glama ricinus communis Rudolph, M.J., Mantis, N. 3.1 X-RAY DIFFRACTION 0.277 0.215 False True IGHV1 7e-10 -12.489520888040902 SPR TBD 6heq A NA 0 PROTEIN BINDING 08/20/18 Prion nanobody 484 CAMELUS DROMEDARIUS camelus dromedarius Soror, S.H., Abskharon, R.N., Wohlkonig, A. 1.23 X-RAY DIFFRACTION 0.224 0.199 False True IGHV3 None None None None None 3jcc C B 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/25/15 Structure of Simian Immunodeficiency Virus Envelope Spikes bound with CD4 and Monoclonal Antibody 36D5 HOMO SAPIENS; SIMIAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens simian immunodeficiency virus Hu, G., Liu, J., Roux, K., Taylor, K.A. NOT ELECTRON MICROSCOPY False False IGHV4 IGLV3 Lambda None None None None None 1oax J N 0 J Hapten ANQ ACENAPHTHENEQUINONE IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with acenaphthenequinone RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.67 X-RAY DIFFRACTION 0.282 0.238 False True IGHV1 IGLV1 Lambda None None None None None 6z3q H L 0 C | A | B protein | protein | protein NA | NA | NA vp3 | vp1 | vp2 VIRUS 05/21/20 Structure of EV71 in complex with a protective antibody 38-1-10A Fab HOMO SAPIENS; ENTEROVIRUS A71 homo sapiens homo sapiens enterovirus a71 | enterovirus a71 | enterovirus a71 Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6pe9 H L 0 V protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 06/20/19 Crystal Structure of CD40 complexed to FAB516 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Argiriadi, M.A. 3.13 X-RAY DIFFRACTION 0.255 0.216 False True IGHV3 IGKV4 Kappa None None None None None 7pi3 W X 0 V protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 5m30 D NA 0 B protein type vi secretion protein SECRETION SYSTEM 10/13/16 Structure of TssK from T6SS EAEC in complex with nanobody nb18 VICUGNA PACOS; ESCHERICHIA COLI vicugna pacos escherichia coli Nguyen, V.S., Cambillau, C., Spinelli, C., Desmyter, A., Legrand, P., Cascales, E. 2.6 X-RAY DIFFRACTION 0.226 0.207 False True IGHV1 None None None None None 6bb4 I M 0 Q peptide microtubule-associated protein tau IMMUNE SYSTEM 10/16/17 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 2.099 X-RAY DIFFRACTION 0.270 0.218 False False IGHV1 IGKV11 Kappa 1.5400000000000002e-08 -10.658128680238939 Unknown TBD 7c94 B A 0 C peptide NA peptide from podoplanin IMMUNE SYSTEM 06/04/20 Crystal structure of the anti-human podoplanin antibody Fab fragment complex with glycopeptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Suzuki, K., Nakamura, S., Ogasawara, S., Naruchi, K., Shimabukuro, J., Tukahara, N., Kaneko, M.K., Kato, Y., Murata, T. 2.84 X-RAY DIFFRACTION 0.255 0.220 False False IGHV5 IGKV8 Kappa None None None None None 4ij3 C B 0 A protein sulfhydryl oxidase 1 OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR 12/21/12 Oxidoreductase Fragment of Human QSOX1 in Complex with a FAB Fragment from an Anti- Human QSOX1 Antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Fass, D., Grossman, I. 2.7 X-RAY DIFFRACTION 0.237 0.202 False True IGHV2 IGKV6 Kappa None None None None None 6xjz H L 0 A nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - apo form HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 2.488 X-RAY DIFFRACTION 0.264 0.200 False True IGHV3 IGKV1 Kappa None None None None None 6uc6 C NA 0 A protein botulinum neurotoxin type b HYDROLASE/ANTITOXIN 09/15/19 Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-H11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.32006 X-RAY DIFFRACTION 0.222 0.170 False True IGHV1 None None None None None 4m3k B NA 0 A protein beta-lactamase HYDROLASE/IMMUNE SYSTEM 08/06/13 Structure of a single domain camelid antibody fragment cAb-H7S in complex with the BlaP beta-lactamase from Bacillus licheniformis LAMA GLAMA; BACILLUS LICHENIFORMIS lama glama bacillus licheniformis Pain, C., Kerff, F., Herman, R., Sauvage, E., Preumont, S., Charlier, P., Dumoulin, M. 1.48 X-RAY DIFFRACTION 0.195 0.161 False True IGHV1 None None None None None 3mlw H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 1006-15D in complex with an MN V3 peptide HIV-1 M:B_MN; HOMO SAPIENS homo sapiens homo sapiens hiv-1 m Kong, X.-P. 2.7 X-RAY DIFFRACTION 0.291 0.214 False False IGHV5 IGLV1 Lambda None None None None None 3lrg NA B 0 IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain HOMO SAPIENS homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.05 X-RAY DIFFRACTION 0.197 0.170 False True IGLV1 Lambda None None None None None 7jwq A B 0 V peptide NA il-1beta peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-1beta peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 2.001 X-RAY DIFFRACTION 0.232 0.204 False True IGHV1 IGKV1 Kappa None None None None None 7ws1 K J 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Guo, H., Gao, Y., Ji, X., Yang, H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1zan H L 0 IMMUNE SYSTEM 04/06/05 Crystal structure of anti-NGF AD11 Fab RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Covaceuszach, S., Cattaneo, A., Cassetta, A., Lamba, D. 1.7 X-RAY DIFFRACTION 0.242 0.196 False True IGHV2 IGKV12 Kappa None None None None None 5kzp F J 0 C peptide c1 epitope VIRAL PROTEIN/IMMUNE SYSTEM 07/25/16 Structure of the HCV1-C1 Antibody-Antigen Complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Piepenbrink, K.H., Sundberg, E.J. 2.262 X-RAY DIFFRACTION 0.261 0.218 False True IGHV3 IGKV3 Kappa 7e-08 -9.761032709220395 Unknown TBD 6u36 H L 0 B protein proprotein convertase subtilisin/kexin type 9 HYDROLASE/Immune System 08/21/19 PCSK9 in complex with a Fab and compound 14 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lu, J., Soisson, S. 2.7 X-RAY DIFFRACTION 0.251 0.240 False True IGHV3 IGKV3 Kappa None None None None None 2pw1 B A 0 C peptide peptide epitope IMMUNE SYSTEM 05/10/07 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKWNSL HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.6 X-RAY DIFFRACTION 0.240 0.213 False False IGHV2 IGKV1 Kappa None None None None None 1g9e A NA 12 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 3mme H L 0 L carbohydrate NAG polysaccharide IMMUNE SYSTEM 04/19/10 Structure and functional dissection of PG16, an antibody with broad and potent neutralization of HIV-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pancera, M., McLellan, J., Zhou, T., Zhu, J., Kwong, P. 3.97 X-RAY DIFFRACTION 0.317 0.256 False True IGHV3 IGLV2 Lambda None None None None None 1mju H L 0 IMMUNE SYSTEM 08/28/02 1.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12 MUS MUSCULUS mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 1.22 X-RAY DIFFRACTION 0.154 0.123 False True IGHV1 IGKV2 Kappa None None None None None 3qcu H L 0 H Hapten NKN (2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL TETRADECANOATE IMMUNE SYSTEM 01/17/11 Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (14:0) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fleming, J.K., Wojciak, J.M., Campbell, M.-A., Huxford, T. 1.979 X-RAY DIFFRACTION 0.252 0.222 False True IGHV5 IGKV2D Kappa None None None None None 1r24 B A 0 IMMUNE SYSTEM 11/05/98 FAB FROM MURINE IGG3 KAPPA MUS MUSCULUS mus musculus mus musculus Evans, S.V. 3.1 X-RAY DIFFRACTION unknown 0.245 False False IGHV5 IGKV10 Kappa None None None None None 2kh2 B b 75 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 3g5x B A 0 IMMUNE SYSTEM 02/05/09 Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR MUS MUSCULUS mus musculus mus musculus Garrett, T.P.J., Burgess, A.W. 2.3 X-RAY DIFFRACTION 0.289 0.225 False True IGHV3 IGKV14 Kappa None None None None None 7cz5 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/07/20 Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhou, F., Zhang, H., Cong, Z., Zhao, L., Zhou, Q., Mao, C., Cheng, X., Shen, D., Cai, X., Ma, C., Wang, Y., Dai, A., Zhou, Y., Sun, W., Zhao, F., Zhao, S., Jiang, H., Jiang, Y., Yang, D., Xu, H.E., Zhang, Y., Wang, M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5grx G g 0 IMMUNE SYSTEM 08/12/16 Crystal structure of disulfide-bonded diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.002 X-RAY DIFFRACTION 0.215 0.167 True True unknown unknown unknown None None None None None 5cbe C D 0 F protein c-x-c motif chemokine 13 IMMUNE SYSTEM 06/30/15 E10 in complex with CXCL13 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tu, C., Bard, J., Mosyak, L. 2.4 X-RAY DIFFRACTION 0.275 0.248 True True IGHV1 IGLV2 Lambda None None None None None 3pnw B A 0 C protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 7a5s H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/21/20 Complex of SARS-CoV-2 spike and CR3022 Fab (Homogeneous Refinement) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 7lyv H L 0 NA NA NA NA IMMUNE SYSTEM 03/08/21 Crystal structure of the HCMV pentamer-specific antibody 1-103 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., Jones, H.G., McLellan, J.S. 1.9 X-RAY DIFFRACTION 0.217 0.191 False True IGHV4 IGKV1 Kappa None None None None None 6crk H h 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 03/19/18 Heterotrimeric G-protein in complex with an antibody fragment HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Maeda, S., Dawson, R., Kobilka, B. 2.0 X-RAY DIFFRACTION 0.210 0.175 True True unknown unknown unknown None None None None None 7nkr F NA 0 NA NA NA NA VIRAL PROTEIN 02/18/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8210 INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 5.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4ubd S T 0 R | U protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 08/12/14 Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Shore, D.A., Yang, H., Cho, M., Donis, R.O., Stevens, J. 3.5 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 IGKV3 Kappa None None None None None 1kyo J K 0 E protein ubiquinol-cytochrome c reductase iron-sulfursubunit OXIDOREDUCTASE/ELECTRON TRANSPORT 02/05/02 YEAST CYTOCHROME BC1 COMPLEX WITH BOUND SUBSTRATE CYTOCHROME C MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Lange, C., Hunte, C. 2.97 X-RAY DIFFRACTION 0.268 0.229 False True IGHV3 IGKV10 Kappa None None None None None 7k8w N S 0 G protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C119 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sharaf, N.G., Barnes, C.O., Bjorkman, P.J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6wty B C 0 A protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 253245 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.481 X-RAY DIFFRACTION 0.301 0.262 False True IGHV1 IGLV2 Lambda None None None None None 5icx B A 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with CQFDLSTRRLRCGGSK meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.6 X-RAY DIFFRACTION 0.222 0.177 False True IGHV2 IGKV5 Kappa 1.1e-07 -9.493238899799852 Unknown TBD 5u3k A B 0 C peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.2 Fab in Complex with HIV-1 gp41 MPER 662-683 Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 2.637 X-RAY DIFFRACTION 0.283 0.232 False True IGHV3 IGKV1 Kappa None None None None None 5a16 G H 0 04/28/15 Crystal structure of Fab4201 raised against Human Erythrocyte Anion Exchanger 1 MUS MUSCULUS mus musculus mus musculus Arakawa, T., Kobayashi-Yugiri, T., Alguel, Y., Weyand, S., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Ikeda-Suno, C., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A., Kobayashi, T., Hamasaki, N., Iwata, S. 2.5 X-RAY DIFFRACTION 0.2552 0.2128 False False IGHV8 IGKV3 Kappa None None None None None 6mwv K L 0 J protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-58 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 6uup A a 0 NA NA NA NA ANTITUMOR PROTEIN 10/31/19 Structure of anti-hCD33 conditional scFv CAMELIDAE MIXED LIBRARY camelidae mixed library Kimberlin, C.R., Park, S. 2.20002 X-RAY DIFFRACTION 0.237 0.197 True True unknown unknown unknown None None None None None 4iof E F 0 B protein insulin-degrading enzyme HYDROLASE 01/07/13 Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens McCord, L.A., Liang, W.G, Hoey, R., Dowdell, E., Koide, A., Koide, S., Tang, W.J. 3.353 X-RAY DIFFRACTION 0.280 0.232 False True IGHV3 IGKV1 Kappa 4e-09 -11.456840020052727 SPR TBD 4hfw B A 0 IMMUNE SYSTEM 10/05/12 Anti Rotavirus Antibody HOMO SAPIENS homo sapiens homo sapiens Spiller, B.W., Aiyegbo, M., Crowe, J.E. 2.601 X-RAY DIFFRACTION 0.233 0.186 False True IGHV1 IGKV1 Kappa None None None None None 7xod W NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/01/22 SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA lama glama Xu, Y., Wu, C., Liu, H., Yin, W., Xu, H.E. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6jep H L 0 E protein genome polyprotein ANTIVIRAL PROTEIN 02/07/19 Structure of a neutralizing antibody bound to the Zika envelope protein domain III HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q. 2.316 X-RAY DIFFRACTION 0.219 0.166 False True IGHV1 IGLV1 Lambda None None None None None 7mlu H I 0 C protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 6e65 H L 0 IMMUNE SYSTEM 07/23/18 Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody 85RF45.1 HOMO SAPIENS homo sapiens homo sapiens Kundu, P., Semesi, A., Julien, J.P. 1.5 X-RAY DIFFRACTION 0.187 0.175 False True IGHV3 IGLV6 Lambda None None None None None 1g9e A NA 2 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 5y0a D E 0 A protein protein e VIRUS/IMMUNE SYSTEM 07/15/17 Cryo-EM structure of zika virus complexed with Fab of ZKA190 at pH 8.0 and 37 celsius degree ZIKA VIRUS (STRAIN MR 766); HOMO SAPIENS homo sapiens homo sapiens zika virus (strain mr 766) Wang, J.Q., Lok, S.M. 22 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 6pv8 H I 0 A | B protein | protein NA | NA fusion protein of neuronal acetylcholine receptor subunitalpha-3 and soluble cytochrome b562 | fusion protein of neuronal acetylcholine receptor subunitbeta-4 and soluble cytochrome b562 MEMBRANE PROTEIN 07/19/19 Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001 HOMO SAPIENS; ESCHERICHIA COLI O11; MUS MUSCULUS mus musculus mus musculus homo sapiens, escherichia coli o11 | homo sapiens, escherichia coli o11 Gharpure, A., Teng, J., Zhuang, Y., Noviello, C.M., Walsh, R.M., Cabuco, R., Howard, R.J., Zaveri, N.T., Lindahl, E., Hibbs, R.E. 3.87 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 2hkf H L 0 P peptide carbonic anhydrase 9 immune system 07/04/06 Crystal structure of the Complex Fab M75- Peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kral, V., Mader, P., Stouracova, R., Fabry, M., Horejsi, M., Brynda, J. 2.01 X-RAY DIFFRACTION 0.242 0.176 False False IGHV10 IGKV1 Kappa 3.10e-07 -8.89 ITC 25 18041760 6ju0 I M 0 IMMUNE SYSTEM 04/12/19 Mouse antibody 3.3 Fab in complex with PEG MUS MUSCULUS mus musculus mus musculus Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 2.601 X-RAY DIFFRACTION 0.240 0.211 False True IGHV6 IGKV4 Kappa None None None None None 2mmx NA A 3 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6de7 D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM 05/11/18 Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Interdomain Stabilization 113C-429GCG in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.123 X-RAY DIFFRACTION 0.258 0.249 False True unknown unknown unknown None None None None None 7dnh H L 0 E | A protein | protein NA | NA major capsid protein l1 | major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 12/09/20 2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of 2H3 HUMAN PAPILLOMAVIRUS TYPE 58; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 58 | human papillomavirus type 58 He, M.Z., Chi, X., Zha, Z.H., Zheng, Q.B., Gu, Y., Li, S.W., Xia, N.S. 3.64 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV12 Kappa None None None None None 5n88 A NA 0 D protein pc4 and sfrs1-interacting protein IMMUNE SYSTEM 02/23/17 Crystal structure of antibody bound to viral protein HOMO SAPIENS homo sapiens homo sapiens Bao, L., Hannon, C., Cruz-Migoni, A., Ptchelkine, D., Sun, M.-y., Derveni, M., Bunjobpol, W., Chambers, J.S., Simmons, A., Phillips, S.E.V., Rabbitts, T.H. 1.7 X-RAY DIFFRACTION 0.252 0.188 False True IGHV3 1.0129999999999999e-06 -8.177811883783894 SPR TBD 5hi4 C D 0 B protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 1.8 X-RAY DIFFRACTION 0.224 0.200 False True IGHV3 IGLV6 Lambda None None None None None 7pqy H L 0 E protein NA spike protein s1 VIRAL PROTEIN 09/20/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FI-3A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 3.0 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7mta H L 0 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3dus B A 0 A carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/17/08 Crystal structure of SAG506-01, orthorhombic, twinned, crystal 1 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.282 0.253 False True IGHV7 IGKV8 Kappa None None None None None 7fau B NA 0 A protein NA spike protein s1 STRUCTURAL PROTEIN 07/07/21 Structure Determination of the NB1B11-RBD Complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELIDAE camelidae severe acute respiratory syndrome coronavirus2 Shi, Z.Z., Li, X.X., Wang, L., Sun, Z.C., Zhang, H.W., Chen, X.C., Cui, Q.Q., Qiao, H.R., Lan, Z.Y., Zhang, X. 2.08 X-RAY DIFFRACTION 0.228 0.198 False True IGHV1 NA NA None None None None None 5kzp H L 0 A peptide c1 epitope VIRAL PROTEIN/IMMUNE SYSTEM 07/25/16 Structure of the HCV1-C1 Antibody-Antigen Complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Piepenbrink, K.H., Sundberg, E.J. 2.262 X-RAY DIFFRACTION 0.261 0.218 False True IGHV3 IGKV3 Kappa 7e-08 -9.761032709220395 Unknown TBD 4yc2 B C 0 A protein the stabilized inner domain of clade a/e hiv-1 gp120 frome. coli VIRAL PROTEIN/IMMUNE SYSTEM 02/19/15 Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 from E. coli in complex with the antibody A32. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 3.02 X-RAY DIFFRACTION 0.288 0.227 False True IGHV4 IGLV2 Lambda None None None None None 4rfo H L 0 G protein hiv-1 clade a/e gp120 VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 09/26/14 Crystal structure of the ADCC-Potent Antibody N60-I3 Fab in complex with HIV-1 Clade A/E gp120 and M48u1 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 3.2 X-RAY DIFFRACTION 0.277 0.220 False True IGHV4 IGLV2 Lambda None None None None None 6w03 H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 02/28/20 Crystal Structure of HIV-1 BG505 DS-SOSIP.3mut Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.3 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.273 0.230 False True IGHV4 unknown unknown None None None None None 5jqh D NA 0 B protein endolysin,beta-2 adrenergic receptor signaling protein, hydrolase/inhibitor 05/05/16 Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60 LAMA GLAMA; ENTEROBACTERIA PHAGE T4 lama glama enterobacteria phage t4, homo sapiens Staus, D.P., Strachan, R.T., Manglik, A., Pani, B., Kahsai, A.W., Kim, T.H., Wingler, L.M., Ahn, S., Chatterjee, A., Masoudi, A., Kruse, A.C., Pardon, E., Steyaert, J., Weis, W.I., Prosser, R.S., Kobilka, B.K., Costa, T., Lefkowitz, R.J. 3.2 X-RAY DIFFRACTION 0.290 0.247 False True IGHV1 None None None None None 3fb8 A B 0 C protein voltage-gated potassium channel membrane protein/metal transport 11/18/08 KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 3.4 X-RAY DIFFRACTION 0.304 0.284 False False IGHV1 IGKV5 Kappa None None None None None 5o8f O NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5,gamma-aminobutyric acid receptor subunit alpha-5 | gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 06/13/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.2 X-RAY DIFFRACTION 0.242 0.232 False True IGHV1 NA NA None None None None None 6cde 7 8 0 2 protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 3cfk P O 0 O Hapten B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 5grz G g 0 IMMUNE SYSTEM 08/13/16 Crystal structure of disulfide-bonded diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.7 X-RAY DIFFRACTION 0.301 0.246 True True unknown unknown unknown None None None None None 2kh2 B b 21 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7kkh B A 0 B Hapten 91S (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one IMMUNE SYSTEM, ANTITUMOR PROTEIN 10/27/20 P1A4 Fab in complex with ARS1620 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Basu, K., Rohweder, P.J., Zhang, Z., Bohn, M.-F., Shokat, K., Craik, C.S. 2.0 X-RAY DIFFRACTION 0.204 0.185 False True IGHV3 IGLV1 Lambda None None None None None 7f0x B b 0 A protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/07/21 A SARS-CoV-2 neutralizing antibody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Zhang, G., Li, X., Guo, Y., Wang, Y., Yuan, S. 2.8 X-RAY DIFFRACTION 0.270 0.221 True True unknown unknown unknown None None None None None 5hm1 A NA 0 D peptide gp41 IMMUNE SYSTEM 01/15/16 Llama VHH 2E7 in complex with gp41 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama hiv-1 m Hock, M., Caillat, C., Haffke, M., Weissenhorn, W. 2.962 X-RAY DIFFRACTION 0.249 0.194 False True IGHV1 None None None None None 1y18 D C 0 D Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/17/04 Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.252 0.215 False True IGHV4 IGLV1 Lambda None None None None None 6xgc I J 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain ANTIVIRAL PROTEIN 06/17/20 CryoEM structure of influenza hemagglutinin A/Michigan/45/2015 in complex with cyno antibody 1C4 INFLUENZA A VIRUS (A/MICHIGAN/45/2015(H1N1)); MACACA FASCICULARIS macaca fascicularis macaca fascicularis influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Qiu, Y., Zhou, Y. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 6sge D NA 0 A protein rho-related gtp-binding protein rhob IMMUNE SYSTEM 08/04/19 Crystal structure of Human RHOB-GTP in complex with nanobody B6 HOMO SAPIENS homo sapiens homo sapiens Soulie, S., Gence, R., Cabantous, S., Lajoie-Mazenc, I., Favre, G., Pedelacq, J.D. 1.5 X-RAY DIFFRACTION 0.188 0.161 False True IGHV3 None None None None None 7na8 N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/20/21 Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Liu, H., Sun, D., Sun, J., Zhang, C. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2hff B A 0 IMMUNE SYSTEM 06/23/06 Crystal structure of CB2 Fab HOMO SAPIENS homo sapiens homo sapiens Hymowitz, S.G. 1.95 X-RAY DIFFRACTION 0.221 0.189 False True IGHV3 IGKV1 Kappa None None None None None 1bzq K NA 0 D protein protein (rnase a) HYDROLASE/IMMUNE SYSTEM 11/03/98 COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Decanniere, K., Desmyter, A., Gahroudhi, M., Lauwereys, M., Muyldermans, S., Wyns, L. 2.8 X-RAY DIFFRACTION 0.282 0.222 False True IGHV1 None None None None None 5mv3 C D 0 E peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 6lxk J K 0 C protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of Z2B3 D102R Fab in complex with influenza virus neuraminidase from A/Serbia/NS-601/2014 (H1N1) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 3.608 X-RAY DIFFRACTION 0.249 0.215 False True IGHV1 IGLV2 Lambda None None None None None 5dyo H L 0 A Hapten FDS FLUORESCIN IMMUNE SYSTEM 09/25/15 Fab43.1 complex with flourescein MUS MUSCULUS mus musculus mus musculus mus musculus Longenecker, K.L., Judge, R.A. 2.36 X-RAY DIFFRACTION 0.239 0.193 False True IGHV1 IGKV1 Kappa 6.1e-11 -13.935303397861828 Unknown TBD 3cm9 C N 0 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6dc5 B C 0 A protein rsv fusion glycoprotein IMMUNE SYSTEM 05/04/18 RSV prefusion F in complex with AM22 Fab HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Jones, H.G., McLellan, J.S. 3.5 X-RAY DIFFRACTION 0.280 0.217 False True IGHV1 IGKV3 Kappa None None None None None 7b18 H NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/24/20 SARS-CoV-spike bound to two neutralising nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; VICUGNA PACOS lama glama severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6oed H L 0 NA NA NA NA IMMUNE SYSTEM 03/27/19 CRYSTAL STRUCTURE OF THE RV144 C1-C2 SPECIFIC ANTIBODY CH55 FAB HOMO SAPIENS homo sapiens homo sapiens Yan, F., Van, V., Tolbert, W.D., Pazgier, M. 2.461 X-RAY DIFFRACTION 0.312 0.256 False True IGHV1 IGKV3 Kappa None None None None None 7vuj N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/02/21 Cryo-EM structure of a class A orphan GPCR HOMO SAPIENS; BACILLUS CIRCULANS homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Zhou, Y.L., Wu, L.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7o7f H F 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/13/21 Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist HOMO SAPIENS; MUS MUSCULUS; BOS TAURUS mus musculus mus musculus homo sapiens | bos taurus Isaikina, P., Tsai, C.-J., Dietz, N.B., Pamula, F., Goldie, K.N., Schertler, G.F.X., Maier, T., Stahlberg, H., Deupi, X., Grzesiek, S. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV2 Kappa None None None None None 3ifn H L 0 P peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 1.5 X-RAY DIFFRACTION 0.212 0.187 False True IGHV8 IGKV1 Kappa None None None None None 7xjh N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/18/22 Isoproterenol-activated dog beta3 adrenergic receptor HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; UNIDENTIFIED; CANIS LUPUS FAMILIARIS unidentified homo sapiens | rattus norvegicus Shihoya, W., Nureki, O. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7lf2 G I 0 C protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7e6u B NA 0 A protein NA extracellular calcium-sensing receptor STRUCTURAL PROTEIN 02/24/21 the complex of inactive CaSR and NB2D11 HOMO SAPIENS; ESCHERICHIA PHAGE ECSZW-2 escherichia phage ecszw-2 homo sapiens Geng, Y., Chen, X.C., Wang, L., Cui, Q.Q., Ding, Z.Y., Han, L., Kou, Y.J., Zhang, W.Q., Wang, H.N., Jia, X.M., Dai, M., Shi, Z.Z., Li, Y.Y., Li, X.Y. 6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5njd N M 0 K protein NA interleukin-12 subunit beta IMMUNE SYSTEM 03/28/17 Structure of Interleukin 23 in complex with Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 3.9 X-RAY DIFFRACTION 0.312 0.272 False True IGHV3 IGLV1 Lambda None None None None None 7eh5 I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/28/21 Cryo-EM structure of SARS-CoV-2 S-D614G variant in complex with neutralizing antibodies, RBD-chAb15 and RBD-chAb45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Chang, Y.C., Wu, H.C., Hsu, S.T.D. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4uom H L 0 VIRAL PROTEIN 06/05/14 Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC- 83 in complex with neutralizing antibody Fab F5 HOMO SAPIENS homo sapiens homo sapiens Porta, J., Jose, J., Roehrig, J.T., Blair, C.D., Kuhn, R.J., Rossmann, M.G. 17.0 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 3o0r H L 0 B | C protein | protein NA | NA nitric oxide reductase subunit b | nitric oxide reductase subunit c IMMUNE SYSTEM/OXIDOREDUCTASE 07/20/10 Crystal structure of nitric oxide reductase from Pseudomonas aeruginosa in complex with antibody fragment MUS MUSCULUS; PSEUDOMONAS AERUGINOSA mus musculus mus musculus pseudomonas aeruginosa | pseudomonas aeruginosa Hino, T., Matsumoto, Y., Nagano, S., Sugimoto, H., Fukumori, Y., Murata, T., Iwata, S., Shiro, Y. 2.7 X-RAY DIFFRACTION 0.247 0.185 False False IGHV1 IGKV16 Kappa None None None None None 1dzb A a 0 X protein turkey egg-white lysozyme c IMMUNE SYSTEM 02/23/00 Crystal structure of phage library-derived single-chain Fv fragment 1F9 in complex with turkey egg-white lysozyme MUS MUSCULUS; MELEAGRIS GALLOPAVO mus musculus meleagris gallopavo Ay, J., Keitel, T., Kuettner, G., Wessner, H., Scholz, C., Hahn, M., Hoehne, W. 2.0 X-RAY DIFFRACTION 0.306 0.225 True True unknown unknown unknown 5.20e-07 -8.57 Other 25 10926506 5xku C B 0 A protein influenza a virus IMMUNE SYSTEM 05/09/17 Crystal structure of hemagglutinin globular head from an H7N9 influenza virus in complex with a neutralizing antibody HNIgGA6 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Chen, C., Wang, J., Wang, W., Gao, X., Cui, S., Jin, Q. 1.78 X-RAY DIFFRACTION 0.242 0.206 False True IGHV4 IGKV1 Kappa None None None None None 5a8h F E 0 A | B protein | protein NA | NA hiv-1 gp120 | t-cell surface glycoprotein cd4 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | homo sapiens Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 23.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 3cfd H L 0 IMMUNE SYSTEM 03/03/08 Purple-fluorescent antibody EP2-25C10 in complex with its stilbene hapten MUS MUSCULUS mus musculus mus musculus Debler, E.W., Heine, A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.243 0.211 False False IGHV3 IGKV10 Kappa None None None None None 1lhz NA B 0 IMMUNE SYSTEM 04/17/02 Structure of a Human Bence-Jones Dimer Crystallized in U.S. Space Shuttle Mission STS-95: 293K HOMO SAPIENS homo sapiens Terzyan, S.S., DeWitt, C.R., Ramsland, P.A., Bourne, P.C., Edmundson, A.B. 2.3 X-RAY DIFFRACTION 0.226 0.173 False False IGLV2 Lambda None None None None None 1kn4 H L 0 L Hapten PDE PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE IMMUNE SYSTEM 12/18/01 CATALYTIC ANTIBODY D2.3 COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Knossow, M. 1.9 X-RAY DIFFRACTION 0.246 0.213 False False IGHV1 IGKV1 Kappa None None None None None 7kql H L 0 T protein NA hepatitis a virus cellular receptor 2 IMMUNE SYSTEM 11/16/20 Anti-Tim3 antibody Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Deng, X.A., West, S.M., Strop, P. 1.49 X-RAY DIFFRACTION 0.200 0.177 False True IGHV4 IGKV3 Kappa None None None None None 7p5v G NA 0 A protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4o5i W X 0 K protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 6.501 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 IGLV1 Lambda None None None None None 5t93 NA B 0 IMMUNE SYSTEM 09/09/16 Immunoglobulin light chain variable domain AL-T05 HOMO SAPIENS homo sapiens Ramirez-Alvarado, M., Blancas-Mejia, L.M. 1.9 X-RAY DIFFRACTION 0.223 0.171 False True IGLV1 Lambda None None None None None 1maj NA A 13 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4z7n E F 0 C protein NA integrin alpha-iib Membrane protein/Immune system 04/07/15 Integrin alphaIIbbeta3 in complex with AGDV peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Springer, T.A. 2.599 X-RAY DIFFRACTION 0.253 0.230 False True IGHV14 IGKV14 Kappa None None None None None 7qn6 M NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7kdm C NA 0 B | A protein | protein NA | NA ricin chain b | ricin chain a TOXIN 10/08/20 Ricin bound to VHH antibody V5G6 LAMA GLAMA; RICINUS COMMUNIS lama glama ricinus communis | ricinus communis Rudolph, M.J. 2.301 X-RAY DIFFRACTION 0.238 0.187 False True IGHV1 NA NA None None None None None 4olu H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07 in complex with clade A/E 93TH057 HIV-1 gp120 core HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.202 X-RAY DIFFRACTION 0.248 0.199 False True unknown IGKV3 Kappa None None None None None 6cdi m n 0 d protein unknown VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 5w9p D E 0 B protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6aru C B 0 A protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 08/23/17 Structure of Cetuximab Fab mutant in complex with EGFR extracellular domain HOMO SAPIENS homo sapiens homo sapiens homo sapiens Christie, M., Christ, D. 3.2 X-RAY DIFFRACTION 0.267 0.232 False True IGHV2 IGKV5 Kappa None None None None None 7rth o NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 7o31 X NA 0 NA NA NA NA IMMUNE SYSTEM 04/01/21 Crystal structure of the anti-PAS Fab 1.2 in complex with its epitope peptide and the anti-Kappa VHH domain MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama Schilz, J., Schiefner, A., Skerra, A. 1.55 X-RAY DIFFRACTION 0.232 0.194 False True IGHV1 NA NA None None None None None 5alb H L 0 L Hapten TIQ Ticagrelor IMMUNE SYSTEM 03/07/15 Ticagrelor antidote candidate MEDI2452 in complex with ticagrelor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Buchanan, A., Newton, P., Pehrsson, S., Inghardt, T., Antonsson, T., Svensson, P., Sjogren, T., Oster, L., Janefeldt, A., Sandinge, A., Keyes, F., Austin, M., Spooner, J., Penney, M., Howells, G., Vaughan, T., Nylander, S. 2.16 X-RAY DIFFRACTION 0.2592 0.2140 False True IGHV1 IGLV1 Lambda 1.9600000000000002e-11 -14.607976365570464 Unknown TBD 5hgg T NA 0 A protein urokinase-type plasminogen activator HYDROLASE/INHIBITOR 01/08/16 Crystal structure of uPA in complex with a camelid-derived antibody fragment VICUGNA PACOS; HOMO SAPIENS vicugna pacos homo sapiens Yung, K.W.Y., Kromann-Hansen, T., Andreasen, P.A., Ngo, J.C.K. 1.97 X-RAY DIFFRACTION 0.196 0.167 False True IGHV1 5.4e-11 -14.00752112555336 SPR TBD 3v4v H L 0 B | A protein | protein NA | NA integrin beta-7 | integrin alpha-4 CELL ADHESION 12/15/11 crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Yu, Y., Zhu, J., Springer, T.A. 3.1 X-RAY DIFFRACTION 0.231 0.197 False True IGHV1 IGKV1 Kappa None None None None None 6xoc H L 0 NA NA NA NA IMMUNE SYSTEM 07/06/20 Crystal structure of glVRC01 Fab in complex with anti-idiotypic iv4 Fab HOMO SAPIENS homo sapiens homo sapiens Aljedani, S.S., Weidle, C., Pancera, M. 2.45 X-RAY DIFFRACTION 0.240 0.199 False True IGHV1 IGKV3 Kappa None None None None None 2kqn NA A 2 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1zvo D A 0 IMMUNE SYSTEM 06/02/05 Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering HOMO SAPIENS homo sapiens homo sapiens Sun, Z., Almogren, A., Furtado, P.B., Chowdhury, B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV4 IGLV1 Lambda None None None None None 6ol7 H L 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV1 IGKV3 Kappa None None None None None 6med A B 0 IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 2.04 X-RAY DIFFRACTION 0.216 0.182 False True IGHV1 IGKV1 Kappa None None None None None 7zfb J K 0 F protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.08 X-RAY DIFFRACTION 0.308 0.261 False True IGHV3 IGLV3 Lambda None None None None None 1psk H L 0 IMMUNOGLOBULIN 03/03/97 THE CRYSTAL STRUCTURE OF AN FAB FRAGMENT THAT BINDS TO THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE MUS MUSCULUS mus musculus mus musculus Pichla, S.L., Murali, R., Burnett, R.M. 2.8 X-RAY DIFFRACTION 0.326 0.204 False False IGHV1 IGKV4 Kappa None None None None None 5f93 C NA 0 A protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.99 X-RAY DIFFRACTION 0.234 0.181 False True IGHV1 None None None None None 8dce H h 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/16/22 SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 1 Bound to C144 scFv Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens severe acute respiratory syndrome coronavirus2 Tang, W.K., Tolia, N.H. 2 X-RAY DIFFRACTION 0.203 0.177 True True unknown unknown unknown None None None None None 4lhj B NA 0 A protein NA ricin HYDROLASE/IMMUNE SYSTEM 07/01/13 Ricin A chain bound to camelid nanobody (VHH5) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Cheung, J., Franklin, M., Burshteyn, F., Cassidy, M., Gary, E., Mantis, N. 1.8 X-RAY DIFFRACTION 0.250 0.196 False True IGHV1 NA NA None None None None None 6mxs A B 0 IMMUNE SYSTEM 10/31/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98F,HC-G99M] HOMO SAPIENS homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M.S. 1.95 X-RAY DIFFRACTION 0.229 0.191 False True IGHV3 IGKV1 Kappa None None None None None 5t93 NA D 0 IMMUNE SYSTEM 09/09/16 Immunoglobulin light chain variable domain AL-T05 HOMO SAPIENS homo sapiens Ramirez-Alvarado, M., Blancas-Mejia, L.M. 1.9 X-RAY DIFFRACTION 0.223 0.171 False True IGLV1 Lambda None None None None None 6n1w m n 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False False IGHV4 IGLV3 Lambda None None None None None 7a5r I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/21/20 Complex of SARS-CoV-2 spike and CR3022 Fab (Non-Uniform Refinement) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 6mph Y a 0 B protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 3cm9 D O 1 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5hys A B 0 G protein ig epsilon chain c region IMMUNE SYSTEM 02/01/16 Structure of IgE complexed with omalizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Tarchevskaya, S.S., Sathiyamoorthy, K., Jardetzky, T.S. 2.5 X-RAY DIFFRACTION 0.239 0.221 False True IGHV3 IGKV1 Kappa 3.8899999999999996e-11 -14.201849726854265 SPR TBD 3j2y F E 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab 9.8B MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 14.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 5tr1 I M 0 B protein chloride channel protein TRANSPORT PROTEIN 10/25/16 Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation BOS TAURUS; MUS MUSCULUS mus musculus mus musculus bos taurus Park, E., MacKinnon, R. 3.95 ELECTRON MICROSCOPY False False IGHV3 IGKV6 Kappa None None None None None 1ek3 NA A 0 IMMUNE SYSTEM 03/06/00 KAPPA-4 IMMUNOGLOBULIN VL, REC HOMO SAPIENS homo sapiens Pokkuluri, P.R., Huang, D.-B., Raffen, R., Stevens, F.J., Schiffer, M. 1.9 X-RAY DIFFRACTION 0.237 0.187 False True IGKV4 Kappa None None None None None 7luc N O 0 C protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/22/21 Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B RESPIRATORY SYNCYTIAL VIRUS; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus Wrapp, D., McLellan, J.S. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 5gir A B 0 D peptide lys-pro-ile-ile-ile-gly-ser-his-ala-tyr-gly-asp IMMUNE SYSTEM 06/24/16 Crystal structure of a Fab fragment with its ligand peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Kitago, Y., Kaneko, K.K., Ogasawara, S., Kato, Y., Takagi, J. 1.93 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 IGKV5 Kappa None None None None None 7zf5 D F 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-12 and Beta-54 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 5.32 X-RAY DIFFRACTION 0.256 0.249 False True IGHV1 IGKV3 Kappa None None None None None 7shy I J 0 G protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with omalizumab scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.230 0.173 False True IGHV3 IGKV1 Kappa None None None None None 5e7b A NA 0 IMMUNE SYSTEM 10/12/15 Structure of a nanobody (vHH) from camel against phage TP901-1 RBP (BppL, ORF53) CAMELUS DROMEDARIUS camelus dromedarius Legrand, P., Collins, B., Blangy, S., Murphy, J., Spinelli, S., Gutierrez, C., Richet, N., Kellenberger, C., Desmyter, A., Mahony, J., van Sinderen, D., Cambillau, C. 1.1 X-RAY DIFFRACTION 0.189 0.158 False True IGHV1 None None None None None 3cx5 U V 0 P protein cytochrome b-c1 complex subunit rieske, mitochondrial OXIDOREDUCTASE 04/23/08 Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Solmaz, S.R.N., Hunte, C. 1.9 X-RAY DIFFRACTION 0.263 0.245 False True IGHV3 IGKV10 Kappa None None None None None 2qtj A L 9 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6zxn F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/30/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7zml F NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G1-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.79 X-RAY DIFFRACTION 0.260 0.223 False True IGHV1 NA NA None None None None None 7qnw A B 0 E protein NA surface glycoprotein VIRAL PROTEIN 12/23/21 The receptor binding domain of SARS-CoV-2 Omicron variant spike glycoprotein in complex with Beta-55 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.4 X-RAY DIFFRACTION 0.247 0.206 False True IGHV4 IGKV1 Kappa None None None None None 6m87 H G 0 G Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 08/21/18 Fab 10A6 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.609 X-RAY DIFFRACTION 0.265 0.228 False False IGHV1 IGKV4 Kappa None None None None None 1s5i H L 0 IMMUNE SYSTEM 01/21/04 Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure MUS MUSCULUS mus musculus mus musculus Pletnev, V.Z., Goryacheva, E.A., Tsygannik, I.N., Nesmeyanov, V.A., Pletnev, S.V., Pangborn, W., Duax, W. 2.7 X-RAY DIFFRACTION 0.275 0.200 False False IGHV3 IGKV1 Kappa None None None None None 6xoc A B 0 NA NA NA NA IMMUNE SYSTEM 07/06/20 Crystal structure of glVRC01 Fab in complex with anti-idiotypic iv4 Fab HOMO SAPIENS homo sapiens homo sapiens Aljedani, S.S., Weidle, C., Pancera, M. 2.45 X-RAY DIFFRACTION 0.240 0.199 False True IGHV1 IGKV1 Kappa None None None None None 3l7e B A 0 IMMUNE SYSTEM 12/28/09 Crystal structure of ANTI-IL-13 antibody C836 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.5 X-RAY DIFFRACTION 0.251 0.201 False True IGHV8 IGKV16 Kappa None None None None None 2kqn NA A 12 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5m63 H L 0 L carbohydrate GAL polysaccharide IMMUNE SYSTEM 10/24/16 Crystal structure of group B Streptococcus type III DP2 oligosaccharide bound to Fab NVS-1-19-5 ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Carboni, F., Adamo, R., Veggi, D., Rappuoli, R., Malito, E., Margarit, I.R., Berti, F. 2.74 X-RAY DIFFRACTION 0.282 0.236 False True IGHV1 IGKV1 Kappa 1.0999999999999999e-07 -9.493238899799852 Unknown TBD 6plk H L 0 E protein env ANTIVIRAL PROTEIN 07/01/19 Crystal structure of ZIKV-116 Fab in complex with ZIKV envelope DIII HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhao, H., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.3 X-RAY DIFFRACTION 0.211 0.167 False True IGHV3 IGKV1 Kappa None None None None None 4odu H L 0 IMMUNE SYSTEM 01/10/14 Unliganded Fab structure of lipid A-specific antibody S1-15 MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.29 X-RAY DIFFRACTION 0.233 0.187 False False IGHV10 IGKV10 Kappa None None None None None 6zlr H L 0 E protein NA unknown VIRAL PROTEIN 07/01/20 Soaking competent crystal form of the SARS-CoV-2 Receptor Binding Domain (RBD):CR3022 complex. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS de Nicola, G.F., Nichols, C.E. 3.1 X-RAY DIFFRACTION 0.247 0.218 False False IGHV5 IGKV4 Kappa None None None None None 7cth H L 0 C | A protein | protein NA | NA core protein | core protein VIRUS 08/19/20 Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10 DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 | dengue virus 2 Zhang, X., Sharma, A., Duquerroy, S., Zhou, Z.H., Rey, F.A. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 3cfk F E 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 7k7y C NA 0 B protein NA botulinum neurotoxin type e ANTITOXIN 09/24/20 Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 3.6 X-RAY DIFFRACTION 0.288 0.261 False True IGHV1 NA NA None None None None None 5dqd H L 0 H carbohydrate KD2 2-(acetylamino)-6-O-[2-(acetylamino)-2-deoxy-4-O-phosphono-beta-D-glucopyranosyl]-2-deoxy-1-O-phosphono-alpha-D-glucopyranose IMMUNE SYSTEM 09/14/15 Structure of S55-5 Fab in complex with lipid A carbohydrate backbone MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.94 X-RAY DIFFRACTION 0.222 0.172 False False IGHV5 IGKV3 Kappa None None None None None 7phw E F 0 D protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/18/21 PfCyRPA bound to monoclonal antibody Cy.004 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 2.793 X-RAY DIFFRACTION 0.277 0.239 False True unknown unknown unknown None None None None None 1vhp A NA 9 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5i1l B A 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV5-51/IGKV4-1 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 1.95 X-RAY DIFFRACTION 0.258 0.194 False True IGHV5 IGKV4 Kappa None None None None None 6fys C NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 2htk C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/26/06 Structure of the Escherichia coli ClC chloride channel Y445A mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.41 X-RAY DIFFRACTION 0.276 0.266 False False IGHV4 IGKV4 Kappa None None None None None 7e6u D NA 0 C protein NA extracellular calcium-sensing receptor STRUCTURAL PROTEIN 02/24/21 the complex of inactive CaSR and NB2D11 HOMO SAPIENS; ESCHERICHIA PHAGE ECSZW-2 escherichia phage ecszw-2 homo sapiens Geng, Y., Chen, X.C., Wang, L., Cui, Q.Q., Ding, Z.Y., Han, L., Kou, Y.J., Zhang, W.Q., Wang, H.N., Jia, X.M., Dai, M., Shi, Z.Z., Li, Y.Y., Li, X.Y. 6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7mdu E F 0 A | B protein | protein NA | NA surface protein gp120 | transmembrane protein gp41 VIRAL PROTEIN 04/06/21 BG505 SOSIP MD39 in complex with the monoclonal antibodies Rh.33104 mAb.1 and RM20A3 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Antanasijevic, A., Ward, A.B. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7pqg B NA 0 A protein NA sodium/bile acid cotransporter MEMBRANE PROTEIN 09/21/21 Structure of thermostabilised human NTCP in complex with nanobody 87 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Goutam, K., Reyes, N. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6xrj H L 0 NA NA NA NA IMMUNE SYSTEM 07/13/20 Crystal structure of the disulfide linked DH717.1 Fab dimer, derived from a macaque HIV-1 vaccine-induced Env glycan-reactive neutralizing antibody B cell lineage HOMO SAPIENS homo sapiens homo sapiens Manne, K., Nicely, N.I., Acharya, P. 3.15 X-RAY DIFFRACTION 0.282 0.245 False True IGHV4 IGLV2 Lambda None None None None None 4yr6 D E 0 F peptide ace-lys-leu-arg-gly-val-leu-gln-gly-his-leu IMMUNE SYSTEM 03/14/15 Fab fragment of 5G6 in complex with epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tao, Y., Mo, X., Li, R. 2.38 X-RAY DIFFRACTION 0.251 0.212 False False IGHV8 IGKV12 Kappa None None None None None 5n0a H L 0 A protein envelope glycoprotein e Immune System/Viral protein 02/02/17 Crystal structure of A259C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Vaney, M.C., Rouvinski, A., Guardado-Calvo, P., Sharma, A., Rey, F.A. 3.9 X-RAY DIFFRACTION 0.300 0.285 False True IGHV3 IGLV2 Lambda None None None None None 6vms E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 06/17/20 Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane RATTUS NORVEGICUS; HOMO SAPIENS; ENTEROBACTERIA PHAGE T4 homo sapiens rattus norvegicus | homo sapiens Yin, J., Chen, K.M., Clark, M.J., Hijazi, M., Kumari, P., Bai, X., Sunahara, R.K., Barth, P., Rosenbaum, D.M. 3.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6yla H L 0 E protein sars-cov-2 rbd VIRAL PROTEIN 04/06/20 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huo, J., Zhao, Y., Ren, J., Zhou, D., Ginn, H.M., Fry, E.E., Owens, R., Stuart, D.I. 2.42 X-RAY DIFFRACTION 0.237 0.213 False True IGHV5 IGKV4 Kappa None None None None None 3nid E F 0 C protein integrin alpha-iib CELL ADHESION/BLOOD CLOTTING 06/15/10 The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific Antagonist That Does Not Induce Opening HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.3 X-RAY DIFFRACTION 0.215 0.179 False True IGHV14 IGKV14 Kappa None None None None None 7rg9 N NA 0 A protein NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short MEMBRANE PROTEIN 07/14/21 cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA lama glama homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6l8t H L 0 IMMUNE SYSTEM 11/07/19 Crystal structure of the Fab fragment of a humanized HBV therapeutic antibody HOMO SAPIENS homo sapiens homo sapiens He, M.Z., Gu, Y., Li, S.W. 1.766 X-RAY DIFFRACTION 0.192 0.165 False True IGHV3 IGKV1 Kappa None None None None None 6gk4 E NA 0 D protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 Human NBD1 of CFTR in complex with nanobodies D12 and T8 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.91 X-RAY DIFFRACTION 0.295 0.246 False True IGHV1 None None None None None 4g80 G H 0 I protein voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (WT, 3.8 A) HOMO SAPIENS; CIONA INTESTINALIS homo sapiens homo sapiens ciona intestinalis Li, Q. 3.58 X-RAY DIFFRACTION 0.292 0.248 False True IGHV3 IGKV1 Kappa None None None None None 5tq0 H L 0 A | B protein | protein NA | NA nmda glutamate receptor subunit | glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 10/21/16 Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in the presence of EDTA RATTUS NORVEGICUS; XENOPUS LAEVIS; MUS MUSCULUS mus musculus mus musculus xenopus laevis | rattus norvegicus Romero-Hernandez, A., Simorowski, N., Karakas, E., Furukawa, H. 2.7 X-RAY DIFFRACTION 0.246 0.208 False False IGHV9 IGKV5 Kappa None None None None None 5viy H G 0 F protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 6.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7wpf T NA 0 NA NA NA NA VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA lama glama Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7k75 A B 0 E peptide NA pfcsp n-terminal peptide p17 IMMUNE SYSTEM 09/22/20 Crystal structure of MAD2-6 IgA Fab in complex with PfCSP N-terminal peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.192 False True IGHV4 IGKV1 Kappa None None None None None 1mrf H L 0 L nucleic-acid DI 2'-DEOXYINOSINE-5'-MONOPHOSPHATE IMMUNOGLOBULIN 06/13/94 PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB-MONONUCLEOTIDE COMPLEXES MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Cygler, M. 2.4 X-RAY DIFFRACTION unknown 0.184 False True IGHV1 IGKV1 Kappa None None None None None 2vis B A 0 C protein hemagglutinin COMPLEX (HEMAGGLUTININ/IMMUNOGLOBULIN) 12/22/97 INFLUENZA VIRUS HEMAGGLUTININ, (ESCAPE) MUTANT WITH THR 131 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Bizebard, T., Fleury, D., Gigant, B., Wharton, S.A., Skehel, J.J., Knossow, M. 3.25 X-RAY DIFFRACTION 0.267 0.188 False False IGHV2 IGLV1 Lambda 4.00e-06 -7.36 Other 25 9461077 7klw B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 11/01/20 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 2.6 X-RAY DIFFRACTION 0.255 0.206 False True IGHV1 NA NA None None None None None 3qeh C D 0 IMMUNE SYSTEM 01/20/11 Crystal structure of human N12-i15, an ADCC and non-neutralizing anti-HIV-1 Env antibody HOMO SAPIENS homo sapiens homo sapiens Guan, Y., DeVico, A.L., Lewis, G.K., Pazgier, M. 2.59 X-RAY DIFFRACTION 0.254 0.216 False False IGHV1 IGKV2 Kappa None None None None None 6wpw N NA 0 C | D | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN/HORMONE/IMMUNE SYSTEM 04/28/20 GCGR-Gs signaling complex bound to a designed glucagon derivative HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Hilger, D., Krishna Kumar, K., Hu, H., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5f3h E F 0 L protein growth/differentiation factor 8 Signaling Protein/Immune System 12/02/15 Structure of myostatin in complex with humanized RK35 antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Parris, K.D., Mosyak, L. 2.7 X-RAY DIFFRACTION 0.270 0.218 False True IGHV3 IGKV1 Kappa None None None None None 5gxb B NA 0 A protein lactose permease TRANSPORT PROTEIN 09/16/16 crystal structure of a LacY/Nanobody complex VICUGNA PACOS; ESCHERICHIA COLI (STRAIN K12) vicugna pacos escherichia coli (strain k12) Jiang, X., Wu, J.P., Yan, N., Kaback, H.R. 3.3 X-RAY DIFFRACTION 0.347 0.340 False True IGHV1 None None None None None 7x7o H L 0 B protein NA spike protein s1 VIRAL PROTEIN 03/10/22 SARS-CoV-2 spike RBD in complex with neutralizing antibody UT28K SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozawa, T., Tani, H., Anraku, Y., Kita, S., Igarashi, E., Saga, Y., Inasaki, N., Kawasuji, H., Yamada, H., Sasaki, S., Somekawa, M., Sasaki, J., Hayakawa, Y., Yamamoto, Y., Morinaga, Y., Kurosawa, N., Isobe, M., Fukuhara, H., Maenaka, K., Hashiguchi, T., Kishi, H., Kitajima, I., Saito, S., Niimi, H. 3.75 X-RAY DIFFRACTION 0.336 0.303 False True IGHV1 IGKV3 Kappa None None None None None 5mv3 R S 0 T peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 4nm8 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 11/14/13 Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Lee, P.S., Wilson, I.A. 4.0041 X-RAY DIFFRACTION 0.292 0.240 False True IGHV1 IGKV4 Kappa 2.5e-09 -11.735309499921595 BLI TBD 1nqb C c 0 IMMUNOGLOBULIN 04/04/97 TRIVALENT ANTIBODY FRAGMENT MUS MUSCULUS mus musculus Williams, R.L., Pei, X.Y. 2.0 X-RAY DIFFRACTION 0.230 0.187 True True unknown unknown unknown None None None None None 4aei H L 0 A protein alpha-mammal toxin aah2 IMMUNE SYSTEM/TOXIN 01/10/12 Crystal structure of the AaHII-Fab4C1 complex ANDROCTONUS AUSTRALIS HECTOR; MUS MUSCULUS mus musculus mus musculus androctonus australis hector Fabrichny, I.P., Mondielli, G., Conrod, S., Martin-Eauclaire, M.F., Bourne, Y., Marchot, P. 2.3 X-RAY DIFFRACTION 0.25403 0.19862 False False IGHV5 IGKV1 Kappa 8.000000000000001e-10 -12.410405717143199 Unknown TBD 2y06 H L 0 P peptide phage display derived antigen IMMUNE SYSTEM 11/30/10 CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-(4-HYDROXY-3-NITROPHENYL) - ACETYL MURINE GERMLINE ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE GDPRPSYISHLL MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.5 X-RAY DIFFRACTION 0.2663 0.2339 False False IGHV1 IGLV1 Lambda 8e-07 -8.317673448912437 Unknown TBD 7rga E NA 0 E Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoCLAMP3:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Alexandrov, K. 2.9 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 7kn4 M N 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-E6 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.291 0.241 False True IGHV4 IGLV1 Lambda None None None None None 3v4u H L 0 P peptide h-2 class i histocompatibility antigen, l-d alpha chain IMMUNE SYSTEM 12/15/11 Structure of a monoclonal antibody complexed with its MHC-I antigen MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K. 1.64 X-RAY DIFFRACTION 0.251 0.213 False False IGHV5 IGKV1 Kappa None None None None None 7k8s O P 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Malyutin, A.G., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1igj D C 0 D Hapten DGX DIGOXIN IMMUNOGLOBULIN 02/19/93 26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY MUS MUSCULUS mus musculus mus musculus mus musculus Jeffrey, P.D., Sheriff, S. 2.5 X-RAY DIFFRACTION unknown 0.176 False True IGHV1 IGKV1 Kappa 4.17e-11 -13.91 Other 20 8234291 5vm4 K NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 7mn8 D C 0 B protein NA receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein SIGNALING PROTEIN/IMMUNE SYSTEM 04/30/21 Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab HOMO SAPIENS; ESCHERICHIA COLI (STRAIN K12) homo sapiens homo sapiens homo sapiens, escherichia coli (strain k12) Diwanji, D., Trenker, R., Verba, K.A., Jura, N. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sp6 B NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus hyaluronan synthase PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2; LAMA GLAMA lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6ol5 A B 0 IMMUNE SYSTEM 04/15/19 Structure of iglb12 Fab in complex with anti-idiotype ib3 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M. 2.9 X-RAY DIFFRACTION 0.250 0.200 False True IGHV1 IGKV17 Kappa None None None None None 7cx4 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/01/20 Cryo-EM structure of the Evatanepag-bound EP2-Gs complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Qu, C., Mao, C., Xiao, P., Shen, Q., Zhong, Y., Yang, F., Shen, D., Tao, X., Zhang, H., Yan, X., Zhao, R., He, J., Guan, Y., Zhang, C., Hou, G., Zhang, P., Yu, X., Guan, Y., Sun, J., Zhang, Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7rku E F 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Jette, C.A., Bjorkman, P.J., Barnes, C.O. 3.2 X-RAY DIFFRACTION 0.231 0.188 False True IGHV4 IGKV1 Kappa None None None None None 4m7k H L 0 IMMUNE SYSTEM 08/12/13 Crystal structure of anti-tissue factor antibody 10H10 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.243 0.205 False True IGHV1 IGKV8 Kappa None None None None None 3mxv H L 0 IMMUNE SYSTEM 05/07/10 Crystal structure of fab fragment of anti-Shh 5E1 chimera MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Hymowitz, S.G., Maun, H.R. 1.9 X-RAY DIFFRACTION 0.224 0.179 False True IGHV1 IGKV6 Kappa None None None None None 2kqm NA B 10 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 4lde B NA 0 A protein lysozyme, beta-2 adrenergic receptor MEMBRANE PROTEIN/HYDROLASE 06/24/13 Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody ENTEROBACTERIA PHAGE T4, HOMO SAPIENS; LAMA GLAMA lama glama enterobacteria phage t4, homo sapiens Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K. 2.79 X-RAY DIFFRACTION 0.256 0.227 False True IGHV1 None None None None None 1ob1 B A 0 C protein major merozoite surface protein IMMUNE SYSTEM 01/22/03 Crystal structure of a Fab complex whith Plasmodium falciparum MSP1-19 PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Pizarro, J.C., Chitarra, V., Verger, D., Holm, I., Petres, S., Dartville, S., Nato, F., Longacre, S., Bentley, G.A. 2.9 X-RAY DIFFRACTION 0.288 0.257 False False IGHV9 IGKV4 Kappa 2.00e-10 -12.29 Other 4 12729744 6pxg H L 0 IMMUNE SYSTEM 07/26/19 Crystal Structure of MERS-CoV neutralizing antibody G2 Fab MUS MUSCULUS mus musculus mus musculus Wang, N., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.225 0.181 False True IGHV1 IGKV3 Kappa None None None None None 7jva H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2A4 neutralizing antibody Fab fragment (local refinement of the receptor-binding domain and Fab variable domains) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 5mes H L 0 A protein induced myeloid leukemia cell differentiation protein mcl-1homolog,induced myeloid leukemia cell differentiation protein mcl-1 IMMUNE SYSTEM 11/16/16 MCL1 FAB COMPLEX IN COMPLEX WITH COMPOUND 29 MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens mus musculus, homo sapiens Hargreaves, D. 2.24 X-RAY DIFFRACTION 0.230 0.180 False True IGHV3 IGLV1 Lambda 3.4000000000000003e-07 -8.824641654650721 Unknown TBD 6xc7 C D 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.3 and CR3022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 2.883 X-RAY DIFFRACTION 0.259 0.219 False True IGHV3 IGKV3 Kappa None None None None None 5bvj D C 0 IMMUNE SYSTEM 06/05/15 The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta HOMO SAPIENS homo sapiens homo sapiens Rondeau, J.M. 2.0 X-RAY DIFFRACTION 0.228 0.186 False True IGHV3 IGKV6 Kappa None None None None None 5nml H NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 5uk4 i NA 0 I protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 6ug9 A B 0 A carbohydrate GAL polysaccharide IMMUNE SYSTEM 09/26/19 Complex of ch28/11 Fab and SSEA-4 (hexagonal form) MUS MUSCULUS mus musculus mus musculus mus musculus Soliman, C., Ramsland, P.A. 2.74 X-RAY DIFFRACTION 0.247 0.170 False True IGHV2 IGKV4 Kappa None None None None None 4j1u F E 0 IMMUNE SYSTEM 02/02/13 Crystal structure of antibody 93F3 unstable variant MUS MUSCULUS mus musculus mus musculus Wang, F. 2.58 X-RAY DIFFRACTION 0.276 0.210 False True IGHV2 IGKV8 Kappa None None None None None 5wko K L 0 W | T protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 07/25/17 Crystal structure of antibody 27F3 recognizing the HA from A/California/04/2009 (H1N1) influenza virus HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wilson, A., Lang, S., Zhu, X. 3.492 X-RAY DIFFRACTION 0.268 0.246 False True IGHV1 IGKV3 Kappa None None None None None 5i73 B C 0 A protein sodium-dependent serotonin transporter MEMBRANE PROTEIN 02/16/16 X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central and allosteric sites HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Green, E.M., Gouaux, E. 3.24 X-RAY DIFFRACTION 0.275 0.233 False True IGHV1 IGKV6 Kappa None None None None None 5jqd C B 0 IMMUNE SYSTEM 05/04/16 Antibody Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Zhang, Z., Prachanronarong, K., Gellatly, K., Marasco, W.A., Schiffer, C.A. 2.591 X-RAY DIFFRACTION 0.242 0.212 False True IGHV1 IGKV3 Kappa None None None None None 1ic7 H L 0 Y protein lysozyme c PROTEIN BINDING/HYDROLASE 03/30/01 CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD32A99A)-HEN LYSOZYME COMPLEX MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Yokota, A., Tsumoto, K., Kondo, H., Nishimiya, Y., Horii, K., Matsushima, M., Ogasahara, K., Yutani, K., Kumagai, I. 2.1 X-RAY DIFFRACTION 0.230 0.177 False True IGHV3 IGKV5 Kappa None None None None None 5w4l D E 0 G protein NA clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 06/12/17 Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in complex with HIV-1 clade A/E gp120, the CD4 mimetic M48U1, and the antibody N5-i5. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 2.92 X-RAY DIFFRACTION 0.292 0.231 False True IGHV1 IGKV3 Kappa None None None None None 7eja H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/01/21 Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Xu, J., Cao, S., Liu, Z., Du, Y. 3.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6w0j A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Closed-gate KcsA incubated in BaCl2/NaCl RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 2.5 X-RAY DIFFRACTION 0.218 0.190 False True IGHV1 IGKV5 Kappa None None None None None 6did K E 0 G | J protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN 05/23/18 HIV Env BG505 SOSIP with polyclonal Fabs from immunized rabbit #3417 post-boost#1 HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Turner, H.L., Cottrell, C.A., Oyen, D., Wilson, I.A., Ward, A.B. 4.71 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6lfv A a 0 NA NA NA NA IMMUNE SYSTEM 12/03/19 Crystal structure of PCB4scFv(hN56D) MUS MUSCULUS mus musculus Nakamura, T., Yamagata, Y., Morioka, H. 1.9 X-RAY DIFFRACTION 0.231 0.189 True True unknown unknown unknown None None None None None 6n50 E NA 0 A protein metabotropic glutamate receptor 5 SIGNALING PROTEIN 11/20/18 Metabotropic Glutamate Receptor 5 Extracellular Domain in Complex with Nb43 and L-quisqualic acid HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Skiniotis, G., Mathiesen, J.M., Kobilka, B.K. 3.751 X-RAY DIFFRACTION 0.300 0.266 False True IGHV1 None None None None None 7lue H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 02/22/21 Prefusion RSV F glycoprotein bound by neutralizing site V-directed antibody ADI-14442 RESPIRATORY SYNCYTIAL VIRUS A2; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus a2 Gilman, M.S.A., McLellan, J.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 4ut9 J N 0 D protein envelope glycoprotein e VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein dimer in complex with the ScFv fragment of the broadly neutralizing human antibody EDE1 C10 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 3.2 X-RAY DIFFRACTION 0.2487 0.1975 False True IGHV1 IGLV2 Lambda None None None None None 7k5y M m 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of a chromatosome containing human linker histone H1.4 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1ai1 H L 0 P peptide aib142 COMPLEX (ANTIBODY/PEPTIDE) 11/06/96 HIV-1 V3 LOOP MIMIC MUS MUSCULUS mus musculus mus musculus Ghiara, J.B., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.220 False False IGHV12 IGKV3 Kappa None None None None None 6phf A B 0 G protein 25 kda ookinete surface antigen IMMUNE SYSTEM 06/25/19 Pfs25 in complex with the human transmission blocking antibody 2587 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum McLeod, B.R., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.267 0.237 False True IGHV1 IGLV3 Lambda None None None None None 6ksn A NA 0 METAL BINDING PROTEIN 08/24/19 Structure of a Zn-bound camelid single domain antibody CAMELUS DROMEDARIUS camelus dromedarius Kumar, S., Athreya, A., Penmatsa, A. 2.15 X-RAY DIFFRACTION 0.232 0.193 False True IGHV1 None None None None None 6oro D E 0 B protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6gwp B NA 0 A protein plasminogen activator inhibitor-1 HYDROLASE 06/25/18 Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 2.28 X-RAY DIFFRACTION 0.225 0.203 False True IGHV1 None None None None None 4pub H L 0 IMMUNE SYSTEM 03/12/14 Crystal structure of Fab DX-2930 HOMO SAPIENS homo sapiens homo sapiens Abendroth, J., Edwards, T.E., Nixon, A., Ladner, R. 1.75 X-RAY DIFFRACTION 0.214 0.172 False True IGHV3 IGKV1 Kappa None None None None None 7wwm I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/13/22 S protein of Delta variant in complex with ZWC6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6xdg B D 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/10/20 Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Franklin, M.C., Saotome, K., Romero Hernandez, A., Zhou, Y. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2h3n NA A 0 B protein ig lambda-5 IMMUNE SYSTEM 05/22/06 Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer HOMO SAPIENS homo sapiens homo sapiens Bankovich, A.J., Garcia, K.C. 2.3 X-RAY DIFFRACTION 0.281 0.228 False True unknown unknown unknown None None None None None 5ukb d NA 0 D protein nucleocapsid Viral Protein/RNA/Immune System 01/20/17 VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 ESCHERICHIA COLI; VESICULAR STOMATITIS INDIANA VIRUS; VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 5.473 X-RAY DIFFRACTION 0.338 0.336 False False IGHV1 None None None None None 7czd A NA 0 B protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 09/08/20 Crystal structure of PD-L1 in complex with a VHH LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Wang, C. 1.64 X-RAY DIFFRACTION 0.184 0.150 False True IGHV3 NA NA None None None None None 4tul H L 0 I peptide peptide2 IMMUNE SYSTEM 06/24/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus phage #d Golik, P., Grudnik, P., Dubin, G., Zdzalik, M., Rokita, H., Horwacik, I. 1.4 X-RAY DIFFRACTION 0.217 0.188 False True IGHV1 IGKV1 Kappa None None None None None 7kgu D C 0 NA NA NA NA IMMUNE SYSTEM 10/18/20 Structure of 2Q1-Fab, an antibody selective for IDH2R140Q-HLA-B*07:02 HOMO SAPIENS homo sapiens homo sapiens Miller, M.S., Aytenfisu, T.Y., Wright, K.M., Gabelli, S.B. 2.4 X-RAY DIFFRACTION 0.269 0.208 False True IGHV3 IGKV1 Kappa None None None None None 1ncb H L 0 N protein influenza a subtype n9 neuraminidase HYDROLASE(O-GLYCOSYL) 01/21/92 CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Tulip, W.R., Varghese, J.N., Colman, P.M. 2.5 X-RAY DIFFRACTION unknown 0.165 False False IGHV9 IGKV6 Kappa None None None None None 2kqm NA A 8 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6p8n B D 0 A protein env outer domain eod-gt8 IMMUNE SYSTEM 06/07/19 Crystal Structure of Antibody P-p1f1 in Complex with eOD-GT8 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Weidle, C., Pancera, M. 3.202 X-RAY DIFFRACTION 0.287 0.226 False True IGHV1 IGKV8 Kappa None None None None None 6mwc C D 0 B protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.5 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 1u6a H L 0 immune system 07/29/04 Crystal Structure of the Broadly Neutralizing Anti-HIV Fab F105 HOMO SAPIENS homo sapiens homo sapiens Wilkinson, R.A., Piscitelli, C., Teintze, M., Lawrence, C.M. 2.81 X-RAY DIFFRACTION 0.251 0.210 False True IGHV4 IGKV3 Kappa None None None None None 4tnw I O 0 D protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False IGHV1 IGLV1 Lambda None None None None None 7tm0 I H 0 A protein NA spike glycoprotein VIRUS 01/19/22 SARS-CoV-2 S B.1.1.529 Omicron variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5u3j H L 0 A peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.1 Fab in Complex with HIV-1 gp41 MPER Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 2.74 X-RAY DIFFRACTION 0.264 0.229 False True IGHV3 IGKV1 Kappa None None None None None 7v69 S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/20/21 Cryo-EM structure of a class A GPCR-G protein complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens | homo sapiens Wang, J.J., Wu, M., Wu, L.J., Hua, T., Liu, Z.J., Wang, T. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7m7w C D 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/29/21 Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 2.65 X-RAY DIFFRACTION 0.271 0.221 False True IGHV5 IGLV2 Lambda None None None None None 4pir H NA 0 B protein 5-hydroxytryptamine receptor 3a TRANSPORT PROTEIN 05/09/14 X-ray structure of the mouse serotonin 5-HT3 receptor MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M.B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X.-D., Poitevin, F., Vogel, H., Nury, H. 3.5 X-RAY DIFFRACTION 0.257 0.217 False True IGHV1 None None None None None 2kqm NA B 18 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7l56 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-43 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 5e7f B NA 0 H protein major structural protein 1 VIRAL PROTEIN 10/12/15 Complex between lactococcal phage Tuc2009 RBP head domain and a nanobody (L06) CAMELUS DROMEDARIUS; LACTOCOCCUS PHAGE TUC2009 camelus dromedarius lactococcus phage tuc2009 Legrand, P., Collins, B., Blangy, S., Murphy, J., Spinelli, S., Gutierrez, C., Richet, N., Kellenberger, C., Desmyter, A., Mahony, J., van Sinderen, D., Cambillau, C. 2.7 X-RAY DIFFRACTION 0.208 0.194 False True IGHV1 9.1e-09 -10.969830253718456 SPR TBD 3chn A L 8 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 5m2m H NA 0 G protein tumor necrosis factor CYTOKINE 10/13/16 Complex between human TNF alpha and Llama VHH3 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.3 X-RAY DIFFRACTION 0.248 0.211 False True IGHV1 1.5000000000000002e-09 -12.037965345328766 SPR TBD 6cxl H L 0 H carbohydrate BMA polysaccharide IMMUNE SYSTEM 04/03/18 anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Stanfield, R.L., Wilson, I.A. 3.586 X-RAY DIFFRACTION 0.248 0.219 False True unknown IGKV1 Kappa None None None None None 2mkw NA A 19 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 5b4m H L 0 IMMUNE SYSTEM 04/05/16 Crystal structure of an Fab against human influenza A MUS MUSCULUS mus musculus mus musculus Yuan, Y.A. 2.4 X-RAY DIFFRACTION 0.338 0.285 False False IGHV5 IGKV3 Kappa None None None None None 2kh2 B b 35 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 3qnz B A 0 C peptide peptide from tubulin beta chain IMMUNE SYSTEM 02/09/11 Orthorhombic form of IgG1 Fab fragment (in complex with antigenic tubulin peptide) sharing same Fv as IgA HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Trajtenberg, F., Correa, A., Buschiazzo, A. 2.2 X-RAY DIFFRACTION 0.235 0.196 False False IGHV3 IGKV2 Kappa None None None None None 6iut H L 0 A protein hemagglutinin IMMUNE SYSTEM 11/30/18 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01 HOMO SAPIENS; INFLUENZA A VIRUS (A/ANHUI/1/2005(H5N1)) homo sapiens homo sapiens influenza a virus (a/anhui/1/2005(h5n1)) Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X. 2.3 X-RAY DIFFRACTION 0.255 0.205 False True IGHV4 IGLV2 Lambda None None None None None 6k5d E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/28/19 Crystal structure of the E148N mutant CLC-ec1 in presence of 200 mM NaBr ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Park, K., Lim, H.H. 3.203 X-RAY DIFFRACTION 0.262 0.215 False True IGHV4 IGKV4 Kappa None None None None None 6p9y N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/10/19 PAC1 GPCR Receptor complex HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R. 3.01 ELECTRON MICROSCOPY False True IGHV3 None None None None None 4l5f H L 0 E protein envelope protein VIRAL PROTEIN, IMMUNE SYSTEM 06/11/13 Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Edeling, M.A., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.45 X-RAY DIFFRACTION 0.239 0.190 False False IGHV1 IGKV17 Kappa None None None None None 7fin N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 07/31/21 Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus | bos taurus Zhao, F.h., Zhou, Q.T., Cong, Z.T., Hang, K.N., Zou, X.Y., Zhang, C., Chen, Y., Dai, A.T., Liang, A.Y., Ming, Q.Q., Wang, M., Chen, L.N., Xu, P.Y., Chang, R.L., Feng, W.B., Xia, T., Zhang, Y., Wu, B.L., Yang, D.H., Zhao, L.H., Xu, H.E., Wang, M.W. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5esq B A 0 IMMUNE SYSTEM 11/16/15 Cetuximab Fab in complex with cyclic beta-alanine-linked meditope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Bzymek, K.P., Williams, J.C. 2.55 X-RAY DIFFRACTION 0.242 0.190 False True IGHV2 IGKV5 Kappa 1.6000000000000001e-06 -7.906995056592657 Unknown TBD 7m8l H K 0 B protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/30/21 EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6c5k A B 0 A carbohydrate GP1 polysaccharide SUGAR BINDING PROTEIN 01/16/18 S25-23 Fab in complex with Chlamydiaceae LPS (Crystal form 2) MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.75 X-RAY DIFFRACTION 0.218 0.188 False False IGHV2 IGKV1 Kappa None None None None None 7mnn K M 0 B protein NA e3 sumo-protein ligase ranbp2 TRANSPORT PROTEIN/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T653I mutant in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 6.7 X-RAY DIFFRACTION 0.263 0.218 False True IGHV3 IGKV1 Kappa None None None None None 2eks B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 03/24/07 Crystal structure of humanized HyHEL-10 FV-HEN lysozyme complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Nakanishi, T., Tsumoto, K., Yokota, A., Kondo, H., Kumagai, I. 2.0 X-RAY DIFFRACTION 0.265 0.221 False True IGHV4 IGKV3 Kappa None None None None None 1uyw H L 0 IMMUNE SYSTEM 03/03/04 Crystal Structure of the antiflavivirus Fab4g2 MUS MUSCULUS mus musculus mus musculus Martinez-Fleites, C., Ortiz-Lombardia, M., Taylor, E.J., Gil-Valdes, J., Chinea, G., Davies, G. 2.0 X-RAY DIFFRACTION 0.21953 0.19943 False False IGHV1 IGKV6 Kappa None None None None None 6ruv R NA 0 Y | X protein | protein NA | NA properdin | properdin IMMUNE SYSTEM 05/29/19 Structure of the SCIN stabilized C3bBb convertase bound to Properdin and a the non-inhibitory nanobody hFPNb1 LAMA GLAMA; HOMO SAPIENS; STAPHYLOCOCCUS AUREUS lama glama homo sapiens | homo sapiens Pedersen, D.V., Andersen, G.R. 6.15 X-RAY DIFFRACTION 0.271 0.242 False True IGHV1 NA NA None None None None None 7a4t A NA 0 C | B peptide | peptide NA | NA gcn4 isoform 1 | gcn4 isoform 1 DE NOVO PROTEIN 08/20/20 Crystal structure of the GCN coiled-coil in complex with nanobody Nb39 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Hadzi, S. 2.124 X-RAY DIFFRACTION 0.243 0.185 False True IGHV1 NA NA None None None None None 3qxu A NA 0 IMMUNE SYSTEM 03/02/11 Free Structure of an Anti-Methotrexate CDR1-3 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.8 X-RAY DIFFRACTION 0.214 0.182 False True IGHV1 None None None None None 7lxz H J 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2L28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6u1t H L 0 IMMUNE SYSTEM 08/16/19 Crystal structure of anti-Nipah virus (NiV) F 5B3 antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Dang, H.V., Chan, Y.P., Park, Y.J., Snijder, J., Da Silva, S.C., Vu, B., Yan, L., Feng, Y.R., Rockx, B., Geisbert, T., Mire, C., Mire, C.E., BBroder, C.C., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.483 X-RAY DIFFRACTION 0.173 0.137 False True IGHV5 IGKV12 Kappa None None None None None 2mmx NA A 14 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 5d1q B A 0 E protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT2 bound by clone D2-06 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN BOVINE RF122 / ET3-1) homo sapiens homo sapiens staphylococcus aureus (strain bovine rf122 /et3-1) Deng, X. 3.22 X-RAY DIFFRACTION 0.288 0.239 False True IGHV1 IGKV1 Kappa 1.3e-11 -14.851238438600605 SPR TBD 1afv H L 0 A protein human immunodeficiency virus type 1 capsidprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/14/97 HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Momany, C., Kovari, L.C., Prongay, A.J., Keller, W., Gitti, R.K., Lee, B.M., Gorbalenya, A.E., Tong, L., Mcclure, J., Ehrlich, L.S., Summers, M.F., Carter, C., Rossmann, M.G. 3.7 X-RAY DIFFRACTION 0.324 0.217 False False IGHV1 IGKV3 Kappa None None None None None 5npj A a 0 D peptide epitope peptide VIRAL PROTEIN 04/16/17 Structure of the Hepatitis C virus strain JFH1 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus hepatitis c virus Vasiliauskaite, I., Rey, F.A., Krey, T. 1.9 X-RAY DIFFRACTION 0.202 0.186 True True unknown unknown unknown None None None None None 5c9k NA A 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 6ral C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return conformation THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 3.5 ELECTRON MICROSCOPY False True IGHV1 None None None None None 4tuo A B 0 B carbohydrate GAL polysaccharide IMMUNE SYSTEM 06/24/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Golik, P., Grudnik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G. 1.55 X-RAY DIFFRACTION 0.206 0.166 False True IGHV1 IGKV1 Kappa None None None None None 3nfp H L 0 I protein interleukin-2 receptor subunit alpha Immune system/Cytokine 06/10/10 Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J. 2.86 X-RAY DIFFRACTION 0.301 0.253 False True IGHV1 IGKV1 Kappa 2.70e-10 -13.05 SPR 25 20820193 6p3s M N 0 O protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 7tcc M N 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 4jan A B 0 I protein envelope glycoprotein gp120 of hiv-1 clade c viral protein/immune system 02/18/13 crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D. 3.15 X-RAY DIFFRACTION 0.256 0.196 False True IGHV4 IGLV3 Lambda 2e-08 -10.503274322962254 SPR TBD 5ifj D E 0 F peptide peptide pro-leu-gln-pro-glu-gln-pro-phe-pro IMMUNE SYSTEM 02/26/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPEQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens triticum aestivum Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 2.35 X-RAY DIFFRACTION 0.241 0.205 False True IGHV3 IGLV4 Lambda None None None None None 1mj8 H L 0 IMMUNE SYSTEM 08/27/02 High Resolution Crystal Structure Of The Fab Fragment of The Esterolytic Antibody MS6-126 MUS MUSCULUS mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 1.75 X-RAY DIFFRACTION 0.221 0.155 False True IGHV1 IGKV2 Kappa None None None None None 4rx4 H L 0 G protein hiv-1 clade a q842.d12 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/08/14 Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC134 in complex with HIV-1 clade A Q842.d12 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Acharya, P., Moquin, S., Kwong, P.D. 3.45 X-RAY DIFFRACTION 0.253 0.208 False True unknown IGKV3 Kappa None None None None None 7euo S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/18/21 The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Wang, X.K., Chen, G., Liao, Q.W., Du, Y., Hu, H.L., Ye, D.Q. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5o0w H NA 0 D protein fructose-bisphosphate aldolase LYASE 05/17/17 Crystal structure of the complex between Nb474 and Trypanosoma congolense fructose-1,6-bisphosphate aldolase TRYPANOSOMA CONGOLENSE (STRAIN IL3000); VICUGNA PACOS vicugna pacos trypanosoma congolense (strain il3000) Pinto, J., Magez, S., Sterckx, Y. 2.57 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 7.382999999999999e-11 -13.822203424535738 SPR TBD 3qny D C 0 IMMUNE SYSTEM 02/09/11 Monoclinic form of human IgA1 Fab fragment, sharing same Fv as IgG HOMO SAPIENS homo sapiens homo sapiens Trajtenberg, F., Correa, A., Buschiazzo, A. 2.3 X-RAY DIFFRACTION 0.218 0.187 False False IGHV3 IGKV2 Kappa None None None None None 7ls9 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/17/21 Cryo-EM structure of neutralizing antibody 1-57 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7keo E F 0 H | G protein | protein NA | NA ubiquitin | ubiquitin PROTEIN BINDING 10/11/20 Crystal structure of K29-linked di-ubiquitin in complex with synthetic antigen binding fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Yu, Y., Zheng, Q., Erramilli, S., Pan, M., Kossiakoff, A., Liu, L., Zhao, M. 2.9 X-RAY DIFFRACTION 0.282 0.236 False True IGHV3 IGKV1 Kappa None None None None None 5fv2 A NA 0 X protein vascular endothelial growth factor 02/02/16 Crystal structure of hVEGF in complex with VH domain antibody HOMO SAPIENS homo sapiens homo sapiens Chung, C., Batuwangala, T. 3.45 X-RAY DIFFRACTION 0.26270 0.21244 False True IGHV3 7.1699999999999995e-12 -15.203792121426005 SPR TBD 6k2i A NA 1 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7kfv F G 0 E protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B12 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.102 X-RAY DIFFRACTION 0.216 0.183 False True IGHV3 IGKV1 Kappa None None None None None 5u68 F f 0 B protein chimera protein of fusion glycoprotein f0 and envelopeglycoprotein VIRAL PROTEIN/Immune System 12/07/16 Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); MYZUS PERSICAE myzus persicae human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Wen, X., Jardetzky, T.S. 3.083 X-RAY DIFFRACTION 0.239 0.184 True True unknown unknown unknown None None None None None 2vxs K O 0 C protein interleukin-17a CYTOKINE 07/09/08 Structure of IL-17A in complex with a potent, fully human neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gerhardt, S., Hargreaves, D., Pauptit, R.A., Davies, R.A., Russell, C., Welsh, F., Tuske, S.J., Coales, S.J., Hamuro, Y., Needham, M.R.C., Langham, C., Barker, W., Bell, P., Aziz, A., Smith, M.J., Dawson, S., Abbott, W.M. 2.63 X-RAY DIFFRACTION 0.264 0.213 False True IGHV3 IGLV6 Lambda 2.10e-09 -11.83 SPR 19835883 3jcx H L 0 A protein capsid protein 2 VIRUS/IMMUNE SYSTEM 03/21/16 Canine Parvovirus complexed with Fab E CANINE PARVOVIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus canine parvovirus Organtini, L.J., Iketani, S., Huang, K., Ashley, R.E., Makhov, A.M., Conway, J.F., Parrish, C.R., Hafenstein, S. 4.1 ELECTRON MICROSCOPY False False IGHV2 IGKV6 Kappa None None None None None 1uz6 W V 0 IMMUNE SYSTEM 03/05/04 anti-Lewis X Fab fragment uncomplexed MUS MUSCULUS mus musculus mus musculus Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P. 2.05 X-RAY DIFFRACTION 0.244 0.198 False False IGHV4 IGKV2 Kappa None None None None None 7zxg B C 0 A protein NA gametocyte surface protein p45/48 CELL ADHESION 05/20/22 Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 4.2 X-RAY DIFFRACTION 0.276 0.259 False True IGHV5 IGKV8 Kappa None None None None None 7phq N NA 0 B protein NA divalent metal cation transporter mnth MEMBRANE PROTEIN 08/18/21 Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA synthetic construct staphylococcus capitis Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 8.45 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7wuh D F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/08/22 SARS-CoV-2 Spike in complex with Fab of m31A7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 5u65 B NA 0 IMMUNE SYSTEM 12/07/16 Camel Nanobody VHH-5 CAMELUS DROMEDARIUS camelus dromedarius Stanfield, R.L., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.261 0.201 False True IGHV1 None None None None None 5o8f L NA 0 B protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 06/13/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.2 X-RAY DIFFRACTION 0.242 0.232 False True IGHV1 NA NA None None None None None 7chf A B 0 R protein NA sars-cov-2 receptor binding domain ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 RBD in complex with BD-604 Fab and BD-368-2 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J., Zhu, Q. 2.674 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV2 Kappa None None None None None 6z7x B A 0 NA NA NA NA PROTEIN BINDING 06/02/20 Insulin analytical antibody OXI-005 Fab MUS MUSCULUS mus musculus mus musculus Johansson, E. 2.15 X-RAY DIFFRACTION 0.253 0.195 False True IGHV5 IGKV19 Kappa None None None None None 4qf1 H L 0 IMMUNE SYSTEM 05/19/14 Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59 HOMO SAPIENS homo sapiens homo sapiens Wiehe, K., Easterhoff, D., Luo, K., Nicely, N.I., Bradley, T., Jaeger, F.H., Dennison, S.M., Zhang, R., Lloyd, K.E., Stolarchuk, C., Parks, R., Sutherland, L.L., Scearce, R.M., Morris, L., Kaewkungwal, J., Nitayaphan, S., Pitisuttithum, P., Rerks-Ngarm, S., Michael, N., Kim, J., Kelsoe, G., Montefiori, D.C., Tomaras, G., Bonsignori, M., Santra, S., Kepler, T.B., Alam, S.M., Moody, M.A., Liao, H.-X., Haynes, B.F. 2.4 X-RAY DIFFRACTION 0.229 0.182 False True IGHV3 IGLV3 Lambda None None None None None 1f4w H L 0 IMMUNE SYSTEM 06/10/00 CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN MUS MUSCULUS mus musculus mus musculus Alzari, P.M., Souchon, H. 2.3 X-RAY DIFFRACTION 0.261 0.197 False False IGHV5 IGLV1 Lambda None None None None None 7fig N NA 0 A | B | G protein | protein | protein NA | NA | NA engineered guanine nucleotide-binding protein g(s) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 07/31/21 luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex BOS TAURUS; RATTUS NORVEGICUS; LAMA GLAMA; HOMO SAPIENS lama glama bos taurus | rattus norvegicus | bos taurus Duan, J., Xu, P., Cheng, X., Mao, C., Croll, T., He, X., Shi, J., Luan, X., Yin, W., You, E., Liu, Q., Zhang, S., Jiang, H., Zhang, Y., Jiang, Y., Xu, H.E. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5kqv P Q 0 F protein insulin receptor,insulin receptor Hormone/Hormone Receptor/Immune System 07/06/16 Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) HOMO SAPIENS; BOS TAURUS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lawrence, M.C., Smith, B.J., Croll, T.I. 4.4 X-RAY DIFFRACTION 0.266 0.229 False False IGHV1 IGKV9 Kappa None None None None None 6cuf 8 7 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 1y18 B A 0 B Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/17/04 Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.252 0.215 False True IGHV4 IGLV1 Lambda None None None None None 2dtm H L 0 IMMUNE SYSTEM 07/13/06 Thermodynamic and structural analyses of hydrolytic mechanism by catalytic antibodies MUS MUSCULUS mus musculus mus musculus Oda, M., Ito, N., Tsumuraya, T., Suzuki, K., Fujii, I. 2.25 X-RAY DIFFRACTION 0.278 0.223 False False IGHV5 IGKV1 Kappa None None None None None 5f6i B C 0 IMMUNE SYSTEM 12/06/15 Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.32 X-RAY DIFFRACTION 0.265 0.218 False True IGHV3 IGLV2 Lambda None None None None None 6xxn H NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 6c5w E NA 0 A protein calcium uniporter MEMBRANE PROTEIN 01/17/18 Crystal structure of the mitochondrial calcium uniporter METARHIZIUM ACRIDUM (STRAIN CQMA 102); ESCHERICHIA COLI K-12 escherichia coli k-12 metarhizium acridum (strain cqma 102) Fan, C., Fan, M., Fastman, N., Zhang, J., Feng, L. 3.1001 X-RAY DIFFRACTION 0.299 0.256 False True IGHV1 None None None None None 5lmj B NA 0 IMMUNE SYSTEM 08/01/16 Llama nanobody PorM_19 LAMA GLAMA lama glama Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.210 0.188 False True IGHV1 None None None None None 7jw0 D C 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/20 SARS-CoV-2 spike in complex with the S304 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Walls, A.C., Park, Y.J., Tortorici, M.A., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7cvt E F 0 B protein NA h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 08/27/20 Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment ESCHERICHIA COLI MS 198-1; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 198-1 Park, K., Mersch, K., Robertson, J., Lim, H.-H. 2.9 X-RAY DIFFRACTION 0.241 0.201 False True IGHV4 IGKV4 Kappa None None None None None 5epm A B 0 C peptide beta-theraphotoxin-cm1a TOXIN/IMMUNE SYSTEM 11/11/15 Ceratotoxin variant in complex with specific antibody Fab fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus ceratogyrus marshalli Strop, P., Shcherbatko, A., Rossi, A. 1.75 X-RAY DIFFRACTION 0.219 0.190 False True IGHV1 IGKV1 Kappa None None None None None 3tnn H L 0 IMMUNE SYSTEM 09/01/11 Crystal structure of N5-i5 Fab, an ADCC mediating and non-neutralizing CD4i anti-HIV- 1 antibody. HOMO SAPIENS homo sapiens homo sapiens Wu, X., Pazgier, M. 1.95 X-RAY DIFFRACTION 0.245 0.198 False True IGHV3 IGLV2 Lambda None None None None None 6djp C D 0 A protein integrin alpha-v MEMBRANE PROTEIN 05/25/18 Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Cormier, A., Campbell, M.G., Nishimura, S.L., Cheng, Y. 4.8 ELECTRON MICROSCOPY False True IGHV3 IGKV4 Kappa None None None None None 7dk2 J K 0 L protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/22/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M., Chen, S. 3.0 X-RAY DIFFRACTION 0.304 0.258 False True IGHV3 IGKV1 Kappa None None None None None 5i1j H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV5-51/IGKV3-11 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.5 X-RAY DIFFRACTION 0.258 0.177 False True IGHV5 IGKV3 Kappa None None None None None 6obo D NA 0 B protein NA ricin a chain TOXIN 03/21/19 Ricin A chain bound to VHH antibody V6A6 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.9 X-RAY DIFFRACTION 0.244 0.207 False True IGHV1 NA NA None None None None None 6p8d A B 0 C peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/10/20 Vaccine-elicited murine FP-targeting antibody vFP6.01 in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 2.102 X-RAY DIFFRACTION 0.309 0.271 False False IGHV1 IGKV2 Kappa None None None None None 4yjz l L 0 E protein hemagglutinin Viral protein/Immune system 03/03/15 Human antibody H2526 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens influenza a virus Schmidt, A.G., Harrison, S.C. 2.72 X-RAY DIFFRACTION 0.266 0.230 True True unknown unknown unknown None None None None None 6vo0 H L 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/29/20 BG505 SOSIP.v5.2 in complex with rabbit Fab 43A2 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Nogal, B., Cottrell, C.A., Ward, A.B. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6wyr H L 0 NA NA NA NA IMMUNE SYSTEM 05/13/20 Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1A HOMO SAPIENS homo sapiens homo sapiens Vieni, C., Ekiert, D. 1.8 X-RAY DIFFRACTION 0.214 0.180 False True IGHV1 IGLV3 Lambda None None None None None 1pw3 NA A 0 IMMUNE SYSTEM 06/30/03 Crystal structure of JtoR68S HOMO SAPIENS homo sapiens Dealwis, C., Gupta, V., Wilkerson, M. 1.9 X-RAY DIFFRACTION 0.233 0.219 False True IGLV6 Lambda None None None None None 4aix NA A 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rC34Y, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.8 X-RAY DIFFRACTION 0.2119 0.1684 False True IGLV3 Lambda None None None None None 5bv7 C B 0 A protein phosphatidylcholine-sterol acyltransferase HYDROLASE/IMMUNE SYSTEM 06/04/15 Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Piper, D.E., Romanow, W.G., Thibault, S.T., Walker, N.P.C. 2.45 X-RAY DIFFRACTION 0.242 0.189 False True IGHV3 IGLV3 Lambda None None None None None 7k60 M m 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of a chromatosome containing human linker histone H1.10 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 3.12 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7kqh H L 0 B protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/16/20 Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Bajic, G., Harrison, S.C. 3.5 X-RAY DIFFRACTION 0.300 0.252 False True IGHV3 IGKV1 Kappa None None None None None 2hmi D C 0 B protein hisubunit of v-1 reverse transcriptase IMMUNE SYSTEM/DNA 04/10/98 HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Ding, J., Das, K., Hsiou, Y., Sarafianos, S.G., Clark Jr., A.D., Jacobo-Molina, A., Tantillo, C., Hughes, S.H., Arnold, E. 2.8 X-RAY DIFFRACTION 0.352 0.271 False False IGHV8 IGKV10 Kappa None None None None None 3uo1 H L 0 P peptide h-2 class i histocompatibility antigen, l-d alpha chain IMMUNE SYSTEM 11/16/11 Structure of a monoclonal antibody complexed with its MHC-I antigen MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K. 1.641 X-RAY DIFFRACTION 0.206 0.185 False False IGHV5 IGKV1 Kappa None None None None None 3hzm B A 0 B carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 06/23/09 Crystal structure of S73-2 antibody in complex with antigen Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Muller-Loennies, S., Borisova, S.N., Brade, L., Kosma, P., Hirama, T., MacKenzie, C.R., Brade, H., Evans, S.V. 1.8 X-RAY DIFFRACTION 0.249 0.207 False False IGHV7 IGKV8 Kappa 3e-06 -7.534554684778222 Unknown TBD 4x4z NA A 0 IMMUNE SYSTEM 12/04/14 Retrofitting antibodies with stabilizing mutations. Herceptin VL mutant F53D. HOMO SAPIENS homo sapiens Langley, D.B., Rouet, R., Christ, D. 1.8 X-RAY DIFFRACTION 0.213 0.177 False True IGKV1 Kappa None None None None None 1t2q H L 0 IMMUNE SYSTEM 04/22/04 The Crystal Structure of an NNA7 Fab that recognizes an N-type blood group antigen MUS MUSCULUS mus musculus mus musculus Xie, K., Song, S.C., Spitalnik, S.L., Wedekind, J.E. 1.83 X-RAY DIFFRACTION 0.247 0.204 False True IGHV2 IGKV1 Kappa None None None None None 7m6e D C 0 E protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, BG10-19 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 3g5y B A 0 E peptide egfr peptide IMMUNE SYSTEM 02/05/09 Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Garrett, T.P.J., Burgess, A.W. 1.59 X-RAY DIFFRACTION 0.250 0.196 False True IGHV3 IGKV14 Kappa 1.54e-07 -9.29 SPR 25 19289842 4lvn C B 0 A protein subtilisin-like serine protease hydrolase/inhibitor/immune system 07/26/13 Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Withers-Martinez, C., Blackman, M.J. 2.25 X-RAY DIFFRACTION 0.237 0.195 False False IGHV3 IGKV4 Kappa None None None None None 7fae H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 S protein of SARS-CoV-2 in complex bound with P36-5D2(state2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, L., Wang, X., Shan, S., Zhang, S. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7jwb D NA 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/25/20 SARS CoV2 Spike ectodomain with engineered trimerized VH binder HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 QCRG Structural Biology Consortium 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4o5i S T 0 G protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 6.501 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 IGLV1 Lambda None None None None None 4w2o G NA 0 H protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody B Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS (STRAIN MUSOKE-80) lama glama lake victoria marburgvirus (strain musoke-80) Taylor, A.B., Garza, J.A. 3.2 X-RAY DIFFRACTION 0.285 0.227 False True IGHV1 None None None None None 2bx5 NA A 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 4yzf E F 0 A protein band 3 anion transport protein IMMUNE SYSTEM 03/25/15 Crystal structure of the anion exchanger domain of human erythrocyte Band 3 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alguel, Y., Arakawa, T., Yugiri, T.K., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Suno, C.I., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A.D., Kobayashi, T., Hamasaki, N., Iwata, S. 3.5 X-RAY DIFFRACTION 0.290 0.274 False False IGHV8 IGKV3 Kappa None None None None None 5c8j A B 0 I protein protein mj0480 MEMBRANE PROTEIN 06/25/15 A YidC-like protein in the archaeal plasma membrane HOMO SAPIENS; METHANOCALDOCOCCUS JANNASCHII (STRAIN ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) homo sapiens homo sapiens methanocaldococcus jannaschii (strain atcc43067 / dsm 2661 / jal-1 / jcm 10045 / nbrc 100440) Borowska, M.T., Dominik, P.K., Anghel, S.A., Kossiakoff, A.A., Keenan, R.J. 3.502 X-RAY DIFFRACTION 0.302 0.253 False True IGHV3 IGKV1 Kappa None None None None None 7e8c D E 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3ixx G H 0 A protein envelope protein e VIRUS 02/26/09 The pseudo-atomic structure of West Nile immature virus in complex with Fab fragments of the anti-fusion loop antibody E53 WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Cherrier, M.V., Kaufmann, B., Nybakken, G.E., Lok, S.M., Warren, J.T., Nelson, C.A., Kostyuchenko, V.A., Holdaway, H.A., Chipman, P.R., Kuhn, R.J., Diamond, M.S., Rossmann, M.G., Fremont, D.H. 15 ELECTRON MICROSCOPY False True IGHV7 IGKV4 Kappa None None None None None 5vqm D C 0 B protein NA toxin b TOXIN/IMMUNE SYSTEM 05/09/17 Clostridium difficile TcdB-GTD bound to PA41 Fab PEPTOCLOSTRIDIUM DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens peptoclostridium difficile Kroh, H.K., Spiller, B.W., Lacy, D.B. 2.79 X-RAY DIFFRACTION 0.292 0.241 False True IGHV1 IGKV3 Kappa None None None None None 7lvw K NA 0 F protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/26/21 Structure of RSV F in Complex with VHH Cl184 RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama respiratory syncytial virus Hsieh, C.-L., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.230 0.201 False True IGHV1 NA NA None None None None None 6d9g A B 0 IMMUNE SYSTEM 04/29/18 X-ray Structure of the FAB Fragment of 15B8, a Murine Monoclonal Antibody Specific for the Human Serotonin Transporter MUS MUSCULUS mus musculus mus musculus Coleman, J.A., Yang, D., Gouaux, E. 2.3 X-RAY DIFFRACTION 0.228 0.195 False True IGHV1 IGKV3 Kappa None None None None None 6mwv O P 0 N protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-58 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 7kyl X Y 0 Z protein NA envelope protein domain iii VIRAL PROTEIN/IMMUNE SYSTEM 12/08/20 Powassan virus Envelope protein DIII in complex with neutralizing Fab POWV-80 POWASSAN VIRUS; MUS MUSCULUS mus musculus mus musculus powassan virus Errico, J.M., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.0 X-RAY DIFFRACTION 0.224 0.190 False False IGHV5 IGKV4 Kappa None None None None None 6y1r B NA 0 NA NA NA NA IMMUNE SYSTEM 02/13/20 Nb22-LBT LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.85 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 NA NA None None None None None 3s62 H L 0 IMMUNE SYSTEM 05/24/11 Structure of Fab fragment of malaria transmission blocking antibody 2A8 against P. vivax P25 protein MUS MUSCULUS mus musculus mus musculus Saxena, A.K. 4.01 X-RAY DIFFRACTION 0.310 0.264 False False IGHV1 IGKV4 Kappa None None None None None 7pgb R S 0 T protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False True IGHV3 IGKV1 Kappa None None None None None 6sne H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.9 X-RAY DIFFRACTION 0.261 0.218 False True IGHV4 IGKV1 Kappa None None None None None 6db7 I M 0 Q peptide hiv-1 gp120 v3 peptide from mn strain IMMUNE SYSTEM 05/02/18 Crystal structure of anti-HIV-1 V3 Fab 1334 in complex with a HIV-1 gp120 V3 peptide from MN strain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.-P. 2.213 X-RAY DIFFRACTION 0.260 0.213 False True IGHV1 IGLV3 Lambda None None None None None 6ymq A a 0 G protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 04/09/20 TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Scacioc, A., Mukhopadhyay, S.M.M., McKinley, G., Graslund, S., Wigren, E., Persson, H., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Di Daniel, E., Davis, J.B., Burgess-Brown, N., Bullock, A. 3.07 X-RAY DIFFRACTION 0.288 0.274 True True unknown unknown unknown None None None None None 6yxd H L 0 A protein NA adiponectin receptor protein 2 MEMBRANE PROTEIN 05/01/20 Room temperature structure of human adiponectin receptor 2 (ADIPOR2) at 2.9 A resolution determined by Serial Crystallography (SSX) using CrystalDirect HOMO SAPIENS homo sapiens homo sapiens homo sapiens Healey, R.D., Basu, S., Humm, A.S., Leyrat, C., Dupeux, F., Pica, A., Granier, S., Marquez, J.A. 2.9 X-RAY DIFFRACTION 0.253 0.199 False True IGHV1 IGKV12 Kappa None None None None None 6w5d H L 0 NA NA NA NA IMMUNE SYSTEM 03/13/20 Crystal Structure of Fab RSB1 HOMO SAPIENS homo sapiens homo sapiens Harshbarger, W., Chandramouli, S., Malito, M. 2.0 X-RAY DIFFRACTION 0.277 0.232 False True IGHV1 IGLV2 Lambda None None None None None 5d9q F E 0 A protein envelope glycoprotein gp120 IMMUNE SYSTEM 08/18/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Ward, A.B., Wilson, I.A. 4.4 X-RAY DIFFRACTION 0.320 0.290 False True IGHV4 IGLV3 Lambda None None None None None 6m87 J I 0 J Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 08/21/18 Fab 10A6 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.609 X-RAY DIFFRACTION 0.265 0.228 False False IGHV1 IGKV4 Kappa None None None None None 7sr8 E e 0 A | B protein | protein NA | NA a modified guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/08/21 Molecular mechanism of the the wake-promoting agent TAK-925 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yin, J., Chapman, K., Lian, P., De Brabander, J.K., Rosenbaum, D.M. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7k39 J I 0 C | D protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation A, neutral pH-like INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5mev H L 0 A protein induced myeloid leukemia cell differentiation protein mcl-1homolog,induced myeloid leukemia cell differentiation protein mcl-1 IMMUNE SYSTEM 11/16/16 MCL1 FAB COMPLEX IN COMPLEX WITH COMPOUND 21 MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens mus musculus, homo sapiens Hargreaves, D. 2.94 X-RAY DIFFRACTION 0.302 0.225 False True IGHV3 IGLV1 Lambda 1e-07 -9.54970862587178 Unknown TBD 5wna H L 0 B peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 07/31/17 Structure of antibody 3D3 bound to the central conserved region of RSV G HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A homo sapiens homo sapiens human respiratory syncytial virus a Fedechkin, S.O., George, N.L., Wolff, J.T., Kauvar, L.M., DuBois, R.M. 2.4 X-RAY DIFFRACTION 0.246 0.192 False True IGHV3 IGKV3 Kappa None None None None None 1f90 H L 0 E peptide antigenic nonapeptide IMMUNE SYSTEM 07/06/00 FAB FRAGMENT OF MONOCLONAL ANTIBODY (LNKB-2) AGAINST HUMAN INTERLEUKIN-2 IN COMPLEX WITH ANTIGENIC PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Afonin, P.V., Fokin, A.V., Tsigannik, I.N., Mikhailova, I.Y., Onoprienko, L.V., Mikhaleva, I.I., Ivanov, V.T., Mareeva, T.Y., Nesmeyanov, V.A., Li, N., Duax, W.L., Pletnev, V.Z. 2.6 X-RAY DIFFRACTION 0.245 0.165 False False IGHV3 IGKV1 Kappa 1.19e-08 -10.8 Other 11468348 4ki5 E F 0 M protein coagulation factor viii IMMUNE SYSTEM 05/01/13 Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Walter, J.D., Meeks, S.L., Healey, J.F., Lollar, P., Spiegel, P.C. 2.47 X-RAY DIFFRACTION 0.238 0.188 False False IGHV1 IGKV9 Kappa None None None None None 3iy1 B A 0 IMMUNE SYSTEM 04/09/09 Variable domains of the WAM of Fab B fitted into the cryoEM reconstruction of the virus-Fab B complex RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 18 ELECTRON MICROSCOPY False False IGHV1 IGKV19 Kappa None None None None None 7d0d H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-3C12_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, R.K., Ju, B., Yu, J.F., Zhang, Y.Y., Liu, N., Wang, H.W., Wang, X.Q., Zhang, L.Q., Zhou, Q. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV4 Kappa None None None None None 2qtj B M 0 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 2kh2 B b 55 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7r40 D F 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/08/22 Structure of the SARS-CoV-2 spike glycoprotein in complex with the 87G7 antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hurdiss, D.L. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5m6a NA B 0 IMMUNE SYSTEM 10/24/16 Crystal structure of cardiotoxic Bence-Jones light chain dimer H9 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 1.64 X-RAY DIFFRACTION 0.203 0.183 False False IGLV2 Lambda None None None None None 6ii8 J K 0 E protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L4B-18 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.32 X-RAY DIFFRACTION 0.251 0.203 False True IGHV3 IGLV6 Lambda 3.8600000000000004e-07 -8.749460362550247 SPR TBD 7si0 I J 0 G protein NA ige fc IMMUNE SYSTEM 10/12/21 IgE-Fc in complex with 813 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.261 0.210 False True IGHV3 IGKV1 Kappa None None None None None 5e5m B NA 0 A protein cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 10/08/15 Crystal structure of mouse CTLA-4 in complex with nanobody MUS MUSCULUS mus musculus mus musculus Fedorov, A.A., Fedorov, E.V., Samanta, D., Bonanno, J.B., Almo, S.C. 2.182 X-RAY DIFFRACTION 0.247 0.193 False True IGHV1 None None None None None 6cjk B A 0 IMMUNE SYSTEM 02/26/18 Anti HIV Fab 10A ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Hangartner, L., Ward, A.B., Wilson, I.A., Oyen, D. 1.795 X-RAY DIFFRACTION 0.206 0.163 False True IGHV1 IGKV1 Kappa None None None None None 1cr9 H L 0 IMMUNE SYSTEM 08/14/99 CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 MUS MUSCULUS mus musculus mus musculus Kanyo, Z.F., Pan, K.M., Williamson, R.A., Burton, D.R., Prusiner, S.B., Fletterick, R.J., Cohen, F.E. 2.0 X-RAY DIFFRACTION 0.217 0.171 False False IGHV14 IGKV1 Kappa None None None None None 2r23 B A 0 B carbohydrate KO1 polysaccharide IMMUNE SYSTEM 08/24/07 Crystal structure of S25-2 Fab in complex with Kdo analogues MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 1.65 X-RAY DIFFRACTION 0.264 0.228 False False IGHV7 IGKV8 Kappa 0.00018999999999999998 -5.076688405139296 Unknown TBD 6v4o A B 0 I protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 2E01 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5f93 F NA 0 E protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.99 X-RAY DIFFRACTION 0.234 0.181 False True IGHV1 None None None None None 4mhh H L 0 E protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/Viet Nam/1203/2004 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 3.564 X-RAY DIFFRACTION 0.238 0.201 False True IGHV1 IGKV3 Kappa 9.000000000000001e-10 -12.340621190735936 BLI TBD 6v4o D E 0 W protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 2E01 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2mkw NA A 7 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 7lxx H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2L28 Local Refinement HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 4z5r Z Y 0 X protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 5f21 B NA 0 A protein adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 HYDROLASE/IMMUNE SYSTEM 12/01/15 human CD38 in complex with nanobody MU375 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Hao, Q., Zhang, H. 1.9 X-RAY DIFFRACTION 0.211 0.163 False True IGHV1 None None None None None 7v0v A NA 13 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7wuj N NA 0 A protein NA mini-gs MEMBRANE PROTEIN 02/08/22 Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 HOMO SAPIENS; PSYCHROMONAS SP. B3M02; SYNTHETIC CONSTRUCT; LAMA GLAMA lama glama homo sapiens Guo, S.C., Huang, S.M., He, Q.T., Xiao, P., Sun, J.P., Yu, X. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7kq7 H L 0 B protein NA interleukin-21 receptor PROTEIN BINDING/Immune System 11/13/20 Crystal structure of IL21R in complex with an antibody Fab fragment RATTUS NORVEGICUS; HOMO SAPIENS rattus norvegicus rattus norvegicus homo sapiens Mosyak, L., Svenson, K. 2.203 X-RAY DIFFRACTION 0.240 0.215 False True IGHV5 IGKV3 Kappa None None None None None 5umi A B 0 C protein NA toxin a TOXIN/IMMUNE SYSTEM 01/27/17 Clostridium difficile TcdA-CROPs bound to PA50 Fab CLOSTRIDIOIDES DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens clostridioides difficile Kroh, H.K., Chandrasekaran, R., Rosenthal, K., Woods, R., Jin, X., Ohi, M.D., Nyborg, A.C., Rainey, G.J., Warrener, P., Spiller, B.W., Lacy, D.B. 3.23 X-RAY DIFFRACTION 0.290 0.270 False True IGHV1 IGKV3 Kappa None None None None None 4yho H L 0 H Hapten 4CC N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine IMMUNE SYSTEM 02/27/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schiele, F., Nar, H. 1.82 X-RAY DIFFRACTION 0.210 0.180 False True IGHV1 IGKV1 Kappa 1.8e-11 -14.658430977236662 Unknown TBD 6ju0 J N 0 J Hapten TOE 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL IMMUNE SYSTEM 04/12/19 Mouse antibody 3.3 Fab in complex with PEG MUS MUSCULUS mus musculus mus musculus mus musculus Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 2.601 X-RAY DIFFRACTION 0.240 0.211 False True IGHV6 IGKV4 Kappa None None None None None 6pzh H L 0 IMMUNE SYSTEM 07/31/19 Crystal structure of human NA-22 Fab HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.236 0.193 False True IGHV3 IGLV2 Lambda None None None None None 7tm0 N O 0 A protein NA spike glycoprotein VIRUS 01/19/22 SARS-CoV-2 S B.1.1.529 Omicron variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1d6v H L 0 H Hapten HOP (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL IMMUNE SYSTEM 10/15/99 CONFORMATION EFFECTS IN BIOLOGICAL CATALYSIS INTRODUCED BY OXY-COPE ANTIBODY MATURATION MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C. 2.0 X-RAY DIFFRACTION 0.264 0.224 False True IGHV1 IGKV14 Kappa 6.7e-07 -8.422740958876435 Unknown TBD 2omb NA C 0 Immune system 01/21/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(1)21 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.9 X-RAY DIFFRACTION 0.284 0.235 False False IGLV2 Lambda None None None None None 4o02 H L 0 A protein integrin alpha-v Protein binding 12/13/13 AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., van Agthoven, J., Xiong, J., Arnaout, M.A. 3.605 X-RAY DIFFRACTION, 1 0.312 0.246 False False IGHV1 IGKV10 Kappa None None None None None 7n08 H L 0 F peptide NA hiv-1 gp41 immunodominant region IMMUNE SYSTEM 05/25/21 Crystal structure of the 3D6 antibody fragment bound to the HIV-1 gp41 immunodominant region HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 06tg.ht008 Cook, J.D., Lee, J.E. 2.0 X-RAY DIFFRACTION 0.203 0.165 False True IGHV3 IGKV1 Kappa None None None None None 7nd5 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-150 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7cho H L 0 E protein NA spike protein s1 VIRAL PROTEIN 07/06/20 Crystal structure of SARS-CoV-2 antibody P5A-1D2 with RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J., Wang, R., Zhang, Q. 2.561 X-RAY DIFFRACTION 0.247 0.202 False True IGHV3 IGLV1 Lambda None None None None None 5h37 K L 0 B protein structural protein e VIRUS/IMMUNE SYSTEM 10/20/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lim, X.-N., Ooi, J.S.G., Lambert, S., Tan, T.Y., Widman, D., Shi, J., Baric, R.S., Lok, S.-M. 4 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 4qxg H L 0 IMMUNE SYSTEM 07/20/14 Antigen binding fragment of an anti IFNAR1 antibody HOMO SAPIENS homo sapiens homo sapiens Oganesyan, V.Y., Dall'Acqua, W.F. 2.3 X-RAY DIFFRACTION 0.249 0.190 False True IGHV5 IGKV3 Kappa None None None None None 7l2e G J 0 B protein NA spike glycoprotein Viral Protein/IMMUNE SYSTEM 12/16/20 Cryo-EM structure of NTD-directed neutralizing antibody 4-18 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 3dvn H L 0 V | U protein | protein NA | NA ubiquitin | ubiquitin d77 IMMUNE SYSTEM 07/18/08 Crystal structure of K63-specific fab Apu2.16 bound to K63-linked di-ubiquitin HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Hymowitz, S.G. 2.7 X-RAY DIFFRACTION 0.268 0.220 False True IGHV3 IGKV1 Kappa 9.20e-08 -9.59 SPR 18724939 7l0n M N 0 S protein NA spike protein s1 VIRAL PROTEIN/HYDROLASE 12/11/20 Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Dillen, J., Nix, J.C., Croll, T.I., Corti, D. 2.78 X-RAY DIFFRACTION 0.325 0.290 False True IGHV3 IGKV1 Kappa None None None None None 6vi1 B A 0 N peptide NA terminase, large subunit IMMUNE SYSTEM 01/11/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 2.4 X-RAY DIFFRACTION 0.239 0.189 False True IGHV3 IGKV1 Kappa None None None None None 6tcr H L 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 1.45 X-RAY DIFFRACTION 0.184 0.166 False True IGHV3 IGKV1 Kappa None None None None None 6jwc H L 0 IMMUNE SYSTEM 04/19/19 Mouse antibody 2B5 Fab in complex with PEG MUS MUSCULUS mus musculus mus musculus Lee, C.C., Ko, T.P., Su, Y.C., Lin, L.L., Roffler, S.R., Wang, A.H.J. 2.297 X-RAY DIFFRACTION 0.226 0.187 False True IGHV6 IGKV4 Kappa None None None None None 5mvg NA A 0 IMMUNE SYSTEM 01/16/17 Crystal structure of non-amyloidogenic light chain dimer M7 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.2 X-RAY DIFFRACTION 0.239 0.207 False False IGLV3 Lambda None None None None None 1nc4 D C 0 D Hapten DOF (S)-2-(4-NITROBENZYL)-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETATE Immune system 12/04/02 Crystal Structure of Monoclonal Antibody 2D12.5 Fab Complexed with Gd-DOTA MUS MUSCULUS mus musculus mus musculus mus musculus Corneillie, T.M., Fisher, A.J., Meares, C.F. 2.25 X-RAY DIFFRACTION 0.248 0.208 False False IGHV2 IGLV1 Lambda None None None None None 6uc6 D NA 0 B protein botulinum neurotoxin type b HYDROLASE/ANTITOXIN 09/15/19 Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-H11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.32006 X-RAY DIFFRACTION 0.222 0.170 False True IGHV1 None None None None None 6y90 C D 0 B protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN 03/06/20 Structure of full-length CD20 in complex with Rituximab Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kumar, A., Reyes, N. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7mfa U V 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA+P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.286 0.238 False True IGHV3 IGLV3 Lambda None None None None None 5ye3 B A 0 C peptide di-acetylated histone h4 NUCLEAR PROTEIN 09/15/17 Crystal structure of the complex of di-acetylated histone H4 and 2A7D9 Fab fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Matsuda, T., Ito, T., Wakamori, M., Umehara, T. 1.7 X-RAY DIFFRACTION 0.195 0.166 False True IGHV9 IGKV19 Kappa None None None None None 6ztf H L 0 NA NA NA NA IMMUNE SYSTEM 07/20/20 Crystal Structure of the anti-human P-Cadherin Fab CQY684 HOMO SAPIENS homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 1.55 X-RAY DIFFRACTION 0.207 0.188 False True IGHV6 IGKV1 Kappa None None None None None 4qhl A B 0 IMMUNE SYSTEM 05/28/14 I3.2 (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.153 X-RAY DIFFRACTION 0.281 0.237 False True IGHV4 IGLV3 Lambda None None None None None 6k41 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/23/19 cryo-EM structure of alpha2BAR-GoA complex HOMO SAPIENS; MUS MUSCULUS; BOS TAURUS; ENTEROBACTERIA PHAGE RB59 mus musculus homo sapiens | mus musculus Daopeng, Y., Zhongmin, L., Hongwei, W., Brian, K. 2.9 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 5l0q C B 0 A protein disintegrin and metalloproteinase domain-containing protein10 HYDROLASE/IMMUNE SYSTEM 07/28/16 Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7. HOMO SAPIENS; BOS TAURUS homo sapiens homo sapiens bos taurus Xu, K., Saha, N., Nikolov, D.B. 2.759 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV5 Kappa None None None None None 7ahu B A 0 E | F protein | protein NA | NA coagulation factor x | coagulation factor x BLOOD CLOTTING 09/25/20 Anti-FX Fab of mim8 in complex with human FXa HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Johansson, E. 2.6 X-RAY DIFFRACTION 0.263 0.203 False True IGHV5 IGKV3 Kappa None None None None None 5tud F E 0 D protein 5-hydroxytryptamine receptor 2b,soluble cytochrome b562chimera SIGNALING PROTEIN 11/05/16 Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody HOMO SAPIENS; ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus homo sapiens, escherichia coli Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G.W., Basu, S., Boutet, S., James, D., Wang, D., Weierstall, U., Liu, W., Katritch, V., Stevens, R.C., Cherezov, V. 3.0 X-RAY DIFFRACTION 0.247 0.227 False True IGHV1 IGKV4 Kappa None None None None None 6mph X Z 0 A protein pgt122 light chain VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 5i17 B A 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1-69/IGKV3-20 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 3.3 X-RAY DIFFRACTION 0.247 0.202 False True IGHV1 IGKV3 Kappa None None None None None 2qtj C O 1 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7zmv K NA 0 C protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.002 X-RAY DIFFRACTION 0.275 0.242 False True IGHV1 NA NA None None None None None 7mzg H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab PDI 42 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Chan, L.J., Dietrich, M.H., Tan, L.L., Tham, W.H. 2.0 X-RAY DIFFRACTION 0.236 0.200 False True IGHV3 IGKV1 Kappa None None None None None 5t6p D C 0 E peptide muc1 peptide fragment IMMUNE SYSTEM 09/01/16 Crystal structure of therapeutic mAB AR20.5 in complex with MUC1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Brooks, C.L., Movahedin, M. 1.97 X-RAY DIFFRACTION 0.232 0.221 False True IGHV5 IGKV1 Kappa 8.8e-07 -8.26120372284051 Unknown TBD 7rp0 A B 0 C protein NA ph-gated potassium channel kcsa TRANSPORT PROTEIN 08/02/21 Structural Snapshots of Intermediates in the Gating of a K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Reddi, R., Matulef, K., Riederer, E.A., Valiyaveetil, F.I. 2.48 X-RAY DIFFRACTION 0.271 0.242 False True IGHV1 IGKV5 Kappa None None None None None 4nco L K 0 I protein bg505 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/24/13 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Lyumkis, D., Ward, A.B., Wilson, I.A. 4.7 X-RAY DIFFRACTION 0.389 0.375 False True IGHV4 IGLV3 Lambda None None None None None 7zfc A B 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Beta RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs HOMO SAPIENS; LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.24 X-RAY DIFFRACTION 0.299 0.244 False True IGHV3 IGLV3 Lambda None None None None None 4aiz NA D 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of 3mJL2 from the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.75 X-RAY DIFFRACTION 0.2185 0.1662 False True IGLV3 Lambda None None None None None 5tfw H L 0 O protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 09/26/16 Crystal structure of 10E8 Fab light chain mutant2 against the MPER region of the HIV-1 Env, in complex with T117v2 epitope scaffold SYNTHETIC CONSTRUCT; HOMO SAPIENS homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.168 X-RAY DIFFRACTION 0.228 0.169 False True IGHV3 IGLV3 Lambda 1.64e-11 -14.71358553366757 SPR TBD 5m13 B NA 0 IMMUNE SYSTEM 10/07/16 Synthetic nanobody in complex with MBP ESCHERICHIA COLI; SYNTHETIC CONSTRUCT synthetic construct Zimmermann, I., Egloff, P., Seeger, M.A. 1.372 X-RAY DIFFRACTION 0.186 0.168 False True IGHV1 None None None None None 5njg E F 0 A protein atp-binding cassette sub-family g member 2 TRANSPORT PROTEIN 03/28/17 Structure of an ABC transporter: part of the structure that could be built de novo MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Taylor, N.M.I., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P. 3.78 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 4r4n F G 0 E protein NA m48u1 peptide VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 5c0r H L 0 A protein hemagglutinin, envelope glycoprotein, fibritin fusionprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/12/15 Crystal Structure of a Generation 3 Influenza Hemagglutinin Stabilized Stem Complexed with the Broadly Neutralizing Antibody C179 MUS MUSCULUS; INFLUENZA A VIRUS, HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 GROUP M SUBTYPE B, ENTEROBACTERIA PHAGE T4 mus musculus mus musculus influenza a virus, human immunodeficiency virustype 1 group m subtype b, enterobacteria phage t4 Boyington, J.C., kwong, P.D., Nabel, G.J., Mascola, J.R. 3.188 X-RAY DIFFRACTION 0.251 0.199 False True IGHV7 IGKV12 Kappa None None None None None 1uwx H L 0 P peptide class 1 outer membrane protein variable region 2 IMMUNE SYSTEM 02/12/04 P1.2 serosubtype antigen derived from N. meningitidis PorA in complex with Fab fragment STREPTOCOCCUS SP.; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Tzitzilonis, C., Prince, S.M., Collins, R.F., Maiden, M.C.J., Feavers, I.M., Derrick, J.P. 2.2 X-RAY DIFFRACTION 0.265 0.223 False False IGHV9 IGKV12 Kappa 1.60e-06 -7.9 SPR 16470851 6dca K O 0 S peptide microtubule-associated protein tau IMMUNE SYSTEM 05/04/18 Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 2.599 X-RAY DIFFRACTION 0.259 0.189 False False IGHV1 IGKV1 Kappa None None None None None 5ja9 A NA 0 C protein toxin higb-2 TOXIN 04/12/16 Crystal structure of the HigB2 toxin in complex with Nb6 LAMA GLAMA; VIBRIO CHOLERAE SEROTYPE O1 (STRAIN ATCC 39315 / EL TOR INABA N16961) lama glama vibrio cholerae serotype o1 (strain atcc 39315/ el tor inaba n16961) Hadzi, S., Loris, R. 1.849 X-RAY DIFFRACTION 0.241 0.195 False True IGHV1 None None None None None 6w5d A B 0 NA NA NA NA IMMUNE SYSTEM 03/13/20 Crystal Structure of Fab RSB1 HOMO SAPIENS homo sapiens homo sapiens Harshbarger, W., Chandramouli, S., Malito, M. 2.0 X-RAY DIFFRACTION 0.277 0.232 False True IGHV1 IGLV2 Lambda None None None None None 4tnv W f 0 P protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False unknown unknown unknown None None None None None 5y9f R Q 0 D protein NA heavy chain of fab fragment of antibody 28f10 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 7jtr H h 0 G protein NA maltose/maltodextrin-binding periplasmic protein SUGAR BINDING PROTEIN/IMMUNE SYSTEM 08/18/20 Complex of maltose-binding protein (MBP) with single-chain Fv (scFv) MUS MUSCULUS; ESCHERICHIA COLI mus musculus escherichia coli Loll, P.J. 2.5 X-RAY DIFFRACTION 0.237 0.201 True True unknown unknown unknown None None None None None 7m6d A B 0 C protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 RBD in complex with neutralizing antibodies BG4-25 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.259 0.219 False True IGHV5 IGKV4 Kappa None None None None None 3gm0 a A 0 A Hapten B41 (2S)-1-(1,3-BENZODIOXOL-5-YL)-N-METHYLPROPAN-2-AMINE IMMUNE SYSTEM 03/12/09 Anti-methamphetamine single chain Fv in complex with MDMA MUS MUSCULUS mus musculus mus musculus Celikel, R., Peterson, E.C., Owens, M., Varughese, K.I. 2.4 X-RAY DIFFRACTION 0.271 0.214 True True unknown unknown unknown 1.7e-08 -10.599564136380756 Unknown TBD 7mw5 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7phq H L 0 NA NA NA NA MEMBRANE PROTEIN 08/18/21 Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA synthetic construct synthetic construct Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 8.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6xun C D 0 G carbohydrate NAG N-ACETYL-D-GLUCOSAMINE ANTITUMOR PROTEIN 01/20/20 Ab 5b1 bound to CA19-9 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.215 0.169 False True IGHV3 IGLV1 Lambda None None None None None 7cwt L H 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike protein in complex with hb27 and fc05 Fab cocktail SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cui, Z., Wang, X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7nfd D C 0 B protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 02/06/21 Structure of mitoxantrone-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kowal, J., Locher, K., Ni, D., Stahlberg, H. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 2jix H L 0 E protein erythropoietin receptor RECEPTOR/IMMUNE SYSTEM 07/02/07 Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor ESCHERICHIA COLI; HOMO SAPIENS homo sapiens Liu, Z., Stoll, V.S., DeVries, P., Jakob, C.G., Xie, N., Simmer, R.L., Lacy, S.E., Egan, D.A., Harlan, J.E., Lesniewski, R.R., Reilly, E.B. 3.2 X-RAY DIFFRACTION 0.323 0.257 False True IGHV4 IGKV1 Kappa 3.00e-08 -10.26 SPR 17620453 4r7n A B 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 2r0z H L 0 Q peptide gripi peptide fragment IMMUNE SYSTEM 08/21/07 PFA1 FAB complexed with GripI peptide fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Gardberg, A.S., Dealwis, C. 2.096 X-RAY DIFFRACTION 0.261 0.201 False False IGHV8 IGKV1 Kappa 3.40e-06 -7.33 SPR 20 17895381 5v8l J N 0 A protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/22/17 BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV1 IGKV2 Kappa None None None None None 3dur B A 0 A carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/17/08 Crystal structure of SAG173-04 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.86 X-RAY DIFFRACTION 0.247 0.178 False True IGHV7 IGKV8 Kappa None None None None None 2kh2 B b 56 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6kr0 C c 0 NA NA NA NA IMMUNE SYSTEM 08/20/19 Crystal structure of HL homo-diabody HOMO SAPIENS homo sapiens Tanaka, Y. 2.3 X-RAY DIFFRACTION 0.226 0.202 True True unknown unknown unknown None None None None None 7kml J N 0 C protein NA spike glycoprotein Viral protein/Immune System 11/03/20 cryo-EM structure of SARS-CoV-2 spike in complex with Fab 15033-7, three RBDs bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6um5 C D 0 A protein ch848 10.17 dt gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunders, K.O., Haynes, B.F. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 6mwx G H 0 F protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-69 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 8.2 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 4jzn I P 0 K peptide envelope glycoprotein e2 immune system/viral protein 04/03/13 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus (isolate h) Krey, T., Rey, F.A. 2.05 X-RAY DIFFRACTION 0.235 0.198 False True IGHV1 IGLV3 Lambda None None None None None 5esa A B 0 IMMUNE SYSTEM 11/16/15 Crystal structure of anti-HCV E2 antibody HC84-26 HOMO SAPIENS homo sapiens homo sapiens Gao, M., Mariuzza, R. 2.6 X-RAY DIFFRACTION 0.251 0.185 False True IGHV1 IGLV3 Lambda None None None None None 7pgb X Y 0 Z protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False True IGHV3 IGKV1 Kappa None None None None None 4jy5 H L 0 IMMUNE SYSTEM 03/29/13 Crystal structure of human Fab PGT122, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Diwanji, D.C., Burton, D.R., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.242 0.198 False True IGHV4 IGLV3 Lambda None None None None None 7rxd H L 0 B protein NA maltodextrin-binding protein,immunoglobulin g-bindingprotein a,immunoglobulin g-binding protein g STRUCTURAL PROTEIN 08/22/21 CryoEM structure of RBD domain of COVID-19 in complex with Legobody ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS SP.; MUS MUSCULUS; VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 mus musculus mus musculus escherichia coli, staphylococcus aureus,streptococcus sp. Wu, X.D., Rapoport, T.A. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 5ggs C D 0 Y protein programmed cell death protein 1 IMMUNE SYSTEM 06/16/16 PD-1 in complex with pembrolizumab Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heo, Y.S. 1.997 X-RAY DIFFRACTION 0.228 0.180 False True IGHV1 IGKV3 Kappa None None None None None 4d9r H L 0 A protein complement factor d HYDROLASE/IMMUNE SYSTEM 01/11/12 Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murray, J.M., Wiesmann, C. 2.42 X-RAY DIFFRACTION 0.251 0.213 False True IGHV7 IGKV1 Kappa 4e-12 -15.549572288283489 SPR TBD 5j9p A B 0 C protein ph-gated potassium channel kcsa METAL TRANSPORT 04/10/16 KcsA in vitro MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus streptomyces lividans Matulef, K., Valiyaveetil, F.I. 2.85 X-RAY DIFFRACTION 0.266 0.217 False True IGHV1 IGKV5 Kappa None None None None None 6aj7 H L 0 C | B protein | protein NA | NA capsid protein vp3 | capsid protein vp2 VIRUS 08/27/18 The structure of Enterovirus D68 mature virion in complex with Fab 15C5 MUS MUSCULUS; ENTEROVIRUS D68 mus musculus mus musculus enterovirus d68 | enterovirus d68 Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. 3.6 ELECTRON MICROSCOPY False False IGHV1 IGKV9 Kappa None None None None None 7dr4 C D 0 NA NA NA NA IMMUNE SYSTEM 12/25/20 Complex of anti-human IL-2 antibody and human IL-2 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Kim, M.S., Kim, J.E. 2.49 X-RAY DIFFRACTION 0.258 0.195 False True IGHV1 IGKV17 Kappa None None None None None 7p7a A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#68 in a 2up/1flexible conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 4.76 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6vca E F 0 A protein NA 5'-nucleotidase, ecto (cd73), isoform cra_a IMMUNE SYSTEM 12/20/19 TB38 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhou, Y.F., Lord, D.M. 3.73 X-RAY DIFFRACTION 0.264 0.224 False True IGHV3 IGLV8 Lambda None None None None None 6xjw C D 0 B nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - alkylated form without biotin moiety HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 1.918 X-RAY DIFFRACTION 0.227 0.188 False True IGHV3 IGKV1 Kappa None None None None None 6u51 A NA 0 D protein nucleoprotein IMMUNE SYSTEM 08/26/19 Anti-Sudan ebolavirus Nucleoprotein Single Domain Antibody Sudan B (SB) Complexed with Sudan ebolavirus Nucleoprotein C-terminal Domain 610-738 LAMA GLAMA; SUDAN EBOLAVIRUS (STRAIN BONIFACE-76) lama glama sudan ebolavirus (strain boniface-76) Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 2.52 X-RAY DIFFRACTION 0.250 0.208 False True unknown unknown unknown None None None None None 1fj1 B A 0 F protein outer surface protein a IMMUNE SYSTEM 08/07/00 LYME DISEASE ANTIGEN OSPA IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB LA-2 BORRELIA BURGDORFERI; MUS MUSCULUS mus musculus mus musculus borrelia burgdorferi Ding, W., Lawson, C.L. 2.68 X-RAY DIFFRACTION 0.281 0.226 False False IGHV9 IGKV19 Kappa None None None None None 1g9e A NA 6 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 3lrh NA G 0 H peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 5dur H L 0 C protein hemagglutinin IMMUNE SYSTEM 09/20/15 Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4 INFLUENZA A VIRUS (A/ANHUI/1/2005(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1/2005(h5n1)) Zuo, T., Sun, J., Wang, G., Zhou, P., Wang, X., Zhang, L. 2.82 X-RAY DIFFRACTION 0.257 0.208 False True IGHV4 IGLV1 Lambda None None None None None 5fuo H L 0 01/28/16 Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life HOMO SAPIENS homo sapiens homo sapiens Adams, R., Ceska, T. 3.6 X-RAY DIFFRACTION 0.2536 0.2151 False True IGHV3 IGKV1 Kappa None None None None None 5bq7 A B 0 IMMUNE SYSTEM 05/28/15 Crystal structure of chikungunya virus-human Fab 5F-10 fragment HOMO SAPIENS homo sapiens homo sapiens Mangala Prasad, V., Rossmann, M.G. 2.738 X-RAY DIFFRACTION 0.288 0.232 False True IGHV7 IGLV1 Lambda None None None None None 1bre NA C 0 IMMUNOGLOBULIN 07/19/95 IMMUNOGLOBULIN LIGHT CHAIN PROTEIN HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 2.0 X-RAY DIFFRACTION 0.337 0.218 False True IGKV1 Kappa None None None None None 4lmq E I 0 F protein stromal cell-derived factor 1 cell adhesion/immune system 07/10/13 Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhong, Z., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., Wong, T, Chiang, N.Y., Clark, S., Clark, R., Quintana, L., Gribling, P., Suto, E., Barck, K., Corpuz, R., Yao, J., Takkar, R., Lee, W.P., Damico-Beyer, L.A., Carano, R.D., Adams, C., Kelley, R.F., Wang, W., Ferrara, N. 2.773 X-RAY DIFFRACTION 0.301 0.253 False True IGHV3 IGKV1 Kappa 9.230000000000001e-10 -12.325670178389219 BLI TBD 6mpg 3 4 0 A protein envelope glycoprotein gp41 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False True IGHV3 IGKV4 Kappa None None None None None 3hae H L 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a-2 alpha chain | nyeso-1 peptide IMMUNE SYSTEM 05/01/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E. 2.9 X-RAY DIFFRACTION 0.283 0.201 False True IGHV3 IGLV2 Lambda 4.60e-08 -10 SPR 19307587 3ezj B NA 0 A protein general secretion pathway protein gspd PROTEIN TRANSPORT 10/22/08 Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Korotkov, K.V, Pardon, E., Steyaert, J., Hol, W.G. 2.8 X-RAY DIFFRACTION 0.239 0.192 False True IGHV1 None None None None None 6vbp J I 0 K peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH815 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.298 X-RAY DIFFRACTION 0.229 0.180 False True IGHV5 IGKV4 Kappa None None None None None 5t1l D C 0 IMMUNE SYSTEM 08/19/16 Cetuximab Fab in complex with CQA(Ph)2DLSTRRLKC peptide MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.204 0.158 False True IGHV2 IGKV5 Kappa 2.4e-07 -9.031007686639388 Unknown TBD 5xwd H D 0 A protein epidermal growth factor receptor SIGNALING PROTEIN 06/29/17 Crystal structure of the complex of 059-152-Fv and EGFR-ECD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Matsuda, T., Ito, T., Shirouzu, M. 2.894 X-RAY DIFFRACTION 0.331 0.277 False True IGHV4 IGLV3 Lambda 5.900000000000001e-09 -11.22656650399949 SPR TBD 7q0a Y Z 0 B protein NA spike glycoprotein,spike ectodomain,spike protein s2' VIRAL PROTEIN 10/14/21 SARS-CoV-2 Spike ectodomain with Fab FI3A SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; BAT CORONAVIRUS RP3/2004; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, bat coronavirus rp3/2004 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4m61 B A 0 IMMUNE SYSTEM 08/08/13 Crystal structure of unliganded anti-DNA Fab A52 MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Eilat, D., Wilson, I.A. 1.62 X-RAY DIFFRACTION 0.232 0.192 False False IGHV1 IGKV8 Kappa None None None None None 7bts B NA 0 A protein NA lysozyme-beta-1 adrenergic receptor chimera MEMBRANE PROTEIN 04/02/20 Structure of human beta1 adrenergic receptor bound to epinephrine and nanobody 6B9 ENTEROBACTERIA PHAGE T4; HOMO SAPIENS; VICUGNA PACOS vicugna pacos enterobacteria phage t4, homo sapiens Xu, X., Kaindl, J., Clark, M., Hubner, H., Hirata, K., Sunahara, R., Gmeiner, P., Kobilka, B.K., Liu, X. 3.13 X-RAY DIFFRACTION 0.259 0.236 False True IGHV1 NA NA None None None None None 1vhp A NA 18 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 3kym J I 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 6itq C NA 0 C Hapten HCY (11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE IMMUNE SYSTEM 11/24/18 Crystal structure of cortisol complexed with its nanobody at pH 10.5 CAMELUS BACTRIANUS camelus bactrianus camelus bactrianus Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. 1.526 X-RAY DIFFRACTION 0.256 0.223 False True unknown unknown unknown None None None None None 3vrl H L 0 C protein gag protein IMMUNE SYSTEM/VIRAL PROTEIN 04/12/12 Crystal structure of BMJ4 p24 capsid protein in complex with A10F9 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Gu, Y., Cao, F., Li, S., Yuan, Y.A., Xia, N. 3.2 X-RAY DIFFRACTION 0.292 0.211 False False IGHV5 IGKV12 Kappa None None None None None 7p77 H NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1um4 H L 0 H Hapten SH4 (1R)-1-PHENYLETHYL 4-(ACETYLAMINO)BENZYLPHOSPHONATE IMMUNE SYSTEM 09/23/03 Catalytic Antibody 21H3 with hapten MUS MUSCULUS mus musculus mus musculus mus musculus Beuscher IV, A.E., Reuter, J., Olson, A.J., Romesberg, F.E., Schultz, P.G., Wirsching, P., Janda, K.D., Lerner, R.A., Stevens, R.C. 1.8 X-RAY DIFFRACTION 0.249 0.223 False True IGHV1 IGKV9 Kappa None None None None None 7kfw C D 0 B protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B3 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.792 X-RAY DIFFRACTION 0.229 0.189 False True IGHV3 IGKV1 Kappa None None None None None 5t29 H L 0 O protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 08/23/16 Crystal structure of 10E8 Fab light chain mutant3, against the MPER region of the HIV-1 Env, in complex with the MPER epitope scaffold T117v2 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.03 X-RAY DIFFRACTION 0.213 0.174 False True IGHV3 IGLV3 Lambda 3.7900000000000004e-10 -12.85303577200258 SPR TBD 2v7h H L 0 IMMUNE SYSTEM 07/30/07 Crystal structure of an immunogen specific anti-mannopyranoside monoclonal antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Krishnan, L., Sahni, G., Kaur, K.J., Salunke, D.M. 2.8 X-RAY DIFFRACTION 0.2676 0.2424 False False IGHV1 IGKV10 Kappa None None None None None 4kk8 E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148Q mutant of CLC-ec1 deltaNC construct in 100mM fluoride ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.86 X-RAY DIFFRACTION 0.256 0.210 False True IGHV4 IGKV4 Kappa None None None None None 4kkb E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 20mM fluoride and 20mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.021 X-RAY DIFFRACTION 0.268 0.236 False True IGHV4 IGKV4 Kappa None None None None None 4zyp N O 0 B protein fusion glycoprotein f0,fibritin IMMUNE SYSTEM 05/21/15 Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS mus musculus mus musculus human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 5.5 X-RAY DIFFRACTION 0.277 0.211 False True IGHV2 IGKV1 Kappa None None None None None 4wfg G F 0 B protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a Tl+ bound conductive conformation MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 3.0 X-RAY DIFFRACTION 0.236 0.202 False True IGHV1 IGKV4 Kappa None None None None None 2q76 D C 0 IMMUNE SYSTEM 06/06/07 Mouse anti-hen egg white lysozyme antibody F10.6.6 Fab fragment MUS MUSCULUS mus musculus mus musculus Cauerhff, A., Klinke, S., Acierno, J.P., Goldbaum, F.A., Braden, B.C. 2.0 X-RAY DIFFRACTION 0.233 0.196 False False IGHV1 IGKV5 Kappa None None None None None 5w9m B C 0 A protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.7 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6n1v X Z 0 A protein pgt122 light chain VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 1ind H L 0 H Hapten EOT [(1-[(BIS-CARBOXYMETHYL-AMINO)-METHYL]-2-{4-[3-(2-HYDROXY-ETHYL)-THIOUREIDO]-PHENY}-ETHYL)-CARBOXYMETHYL-AMINO]-ACETIC ACID IMMUNOGLOBULIN 06/14/93 HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE MUS MUSCULUS mus musculus mus musculus mus musculus Love, R.A., Butler, W.F. 2.2 X-RAY DIFFRACTION unknown 0.188 False False IGHV5 IGLV1 Lambda 2.50e-10 -13.62 Other 37 8218161 1hkl H L 0 CATALYTIC ANTIBODY 12/20/96 FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY HOMO SAPIENS homo sapiens homo sapiens Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C. 2.68 X-RAY DIFFRACTION 0.244 0.184 False True IGHV14 IGKV9 Kappa None None None None None 3b2u F G 0 E protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 7kxk H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/04/20 SARS-CoV-2 spike protein in complex with Fab 15033-7, 2-""up""-1-""down"" conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J. 5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6ozc H L 0 A carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN 05/20/20 BG505 SOSIP.664 with 2G12 Fab2 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.79 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 5xli c a 0 IMMUNE SYSTEM 05/10/17 Structure of anti-Angiotensin II type2 receptor antibody (D5711-4A03) MUS MUSCULUS mus musculus mus musculus Asada, H., Horita, S., Iwata, S., Hirata, K. 1.696 X-RAY DIFFRACTION 0.216 0.180 False False IGHV5 IGKV4 Kappa None None None None None 6oq6 D NA 0 A protein toxin b TOXIN 04/25/19 Structure of the pore forming fragment of Clostridium difficile toxin B in complex with VHH 5D CLOSTRIDIOIDES DIFFICILE; CAMELIDAE camelidae clostridioides difficile Chen, P., Lam, K., Jin, R. 2.97 X-RAY DIFFRACTION 0.274 0.259 False True IGHV1 None None None None None 6ul4 B NA 0 A protein botulinum neurotoxin type b TOXIN/ANTITOXIN 10/06/19 Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 3.18424 X-RAY DIFFRACTION 0.258 0.204 False True IGHV1 None None None None None 4evn G H 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 2fjf I G 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 6wor H L 0 NA NA NA NA IMMUNE SYSTEM 04/25/20 Structure of the broadly neutralizing antibody HC1AM HOMO SAPIENS homo sapiens homo sapiens Tzarum, N., Wilson, I.A., Law, M. 2.601 X-RAY DIFFRACTION 0.253 0.219 False True IGHV1 IGKV3 Kappa None None None None None 7lll N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/04/21 Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein HOMO SAPIENS; LAMA GLAMA; HELODERMA SUSPECTUM lama glama homo sapiens | homo sapiens Wootten, D., Sexton, P.M., Belousoff, M.J., Danev, R., Zhang, X., Khoshouei, M., Venugopal, H. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4dag H L 0 A protein fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 01/12/12 Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site HUMAN METAPNEUMOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human metapneumovirus Jardetzky, T.S., Wen, X. 3.3904 X-RAY DIFFRACTION 0.289 0.260 False True IGHV3 IGLV3 Lambda None None None None None 7lu9 l k 0 f protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta human immunodeficiency virus 1 Manne, K., Edwards, R.J., Acharya, P. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 3c09 H L 0 D protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 01/18/08 Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR HOMO SAPIENS, MUS MUSCULUS; HOMO SAPIENS homo sapiens, mus musculus homo sapiens, mus musculus homo sapiens Ferguson, K.M., Schmiedel, J., Knoechel, T. 3.2 X-RAY DIFFRACTION 0.299 0.242 False True IGHV1 IGKV1 Kappa 4.30e-08 -10.04 SPR 25 18394559 6vl8 E F 0 E Hapten PEU 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL IMMUNE SYSTEM 01/23/20 Anti-PEG antibody 6-3 Fab fragment in complex with PEG MUS MUSCULUS mus musculus mus musculus mus musculus Nicely, N.I., Huckaby, J.T., Lai, S.K., Jacobs, T.M. 2.42 X-RAY DIFFRACTION 0.240 0.185 False True IGHV9 IGKV8 Kappa None None None None None 1ngz B A 0 IMMUNE SYSTEM 12/18/02 Chimeric Germline Fab 7g12-apo MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Yin, J., Andryski, S.A., Beuscher, A.B., Stevens, R.C., Schultz, P.G. 1.6 X-RAY DIFFRACTION 0.233 0.207 False True IGHV1 IGKV6 Kappa None None None None None 6fxn D E 0 A protein tumor necrosis factor ligand superfamily member 13b IMMUNE SYSTEM 03/09/18 Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lammens, A., Maskos, K., Willen, L., Jiang, X., Schneider, P. 2.9 X-RAY DIFFRACTION 0.231 0.191 False True IGHV1 IGLV3 Lambda None None None None None 3nh7 K O 0 D protein bone morphogenetic protein receptor type-1a IMMUNE SYSTEM 06/14/10 Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mueller, T.D., Harth, S., Sebald, W. 2.7 X-RAY DIFFRACTION 0.280 0.234 False True IGHV3 IGLV3 Lambda 2.00e-08 -10.5 SPR 25 20927405 5boz G NA 0 A protein ricin Hydrolase/Immune system 05/27/15 Ricin A chain bound to camelid nanobody (VHH9)(E1) RICINUS COMMUNIS; LAMA GLAMA lama glama ricinus communis Rudolph, M.J., Mantis, N. 3.1 X-RAY DIFFRACTION 0.277 0.215 False True IGHV1 7e-10 -12.489520888040902 SPR TBD 3muh NA L 0 L carbohydrate NAG polysaccharide IMMUNE SYSTEM 05/03/10 Crystal structure of PG9 light chain HOMO SAPIENS homo sapiens homo sapiens Pejchal, R., Walker, L.M., Burton, D.R., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.277 0.245 False True IGLV2 Lambda None None None None None 7mxe H L 0 G | D protein | protein NA | NA envelope glycoprotein bg505 sosip.664 gp120 | hiv-1 envelope glycoprotein bg505 sosip.664 gp41 ANTIVIRAL PROTEIN/VIRAL PROTEIN 05/19/21 Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Abernathy, M.E., Bjorkman, P.J. 3.7 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7lqv H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/15/21 Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gorman, J., Rapp, M., Kwong, P.D., Shapiro, L. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 2kh2 B b 70 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6wn1 E F 0 D protein NA reticulocyte binding protein 2b CELL INVASION 04/22/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 241242 PLASMODIUM VIVAX SAL-1; HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax sal-1 Chan, L.J., Dietrich, M.H., Tham, W.H. 3.15 X-RAY DIFFRACTION 0.283 0.251 False True IGHV3 IGLV3 Lambda None None None None None 7n9v F NA 0 G protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/21 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Tripler, T.N. 3.45 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 NA NA None None None None None 7p6k I NA 0 F protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/16/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb5 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3whe 9 0 0 L protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 3etb F f 0 J protein anthrax protective antigen IMMUNE SYSTEM/TOXIN 10/07/08 Crystal structure of the engineered neutralizing antibody M18 complexed with anthrax protective antigen domain 4 MUS MUSCULUS; BACILLUS ANTHRACIS mus musculus bacillus anthracis Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D. 3.8 X-RAY DIFFRACTION 0.276 0.232 True True unknown unknown unknown 3.50e-11 -14.26 SPR 25 19361425 7lud A B 0 NA NA NA NA IMMUNE SYSTEM 02/22/21 Crystal structure of Fab ADI-14442 HOMO SAPIENS homo sapiens homo sapiens Rush, S.A., McLellan, J.S. 2.9 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV2 Kappa None None None None None 4ydj A B 0 I protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 02/22/15 Crystal structure of broadly and potently neutralizing antibody 44-VRC13.01 in complex with HIV-1 clade AE strain 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.308 X-RAY DIFFRACTION 0.250 0.223 False True unknown IGLV2 Lambda None None None None None 7tb8 J K 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/21 Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7pgb U V 0 W protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False True IGHV3 IGKV1 Kappa None None None None None 3qeh E F 0 IMMUNE SYSTEM 01/20/11 Crystal structure of human N12-i15, an ADCC and non-neutralizing anti-HIV-1 Env antibody HOMO SAPIENS homo sapiens homo sapiens Guan, Y., DeVico, A.L., Lewis, G.K., Pazgier, M. 2.59 X-RAY DIFFRACTION 0.254 0.216 False False IGHV1 IGKV2 Kappa None None None None None 5c6w H h 0 IMMUNE SYSTEM 06/23/15 anti-CXCL13 scFv - E10 HOMO SAPIENS homo sapiens Tu, C., Bard, J., Mosyak, L. 1.54 X-RAY DIFFRACTION 0.164 0.154 True True unknown unknown unknown None None None None None 6mui K L 0 J protein NA e2 VIRUS/IMMUNE SYSTEM 10/23/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-42 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.7 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 6ibb B NA 0 A protein succinate receptor 1 MEMBRANE PROTEIN 11/29/18 Crystal structure of the rat isoform of the succinate receptor SUCNR1 (GPR91) in complex with a nanobody RATTUS NORVEGICUS; VICUGNA PACOS vicugna pacos rattus norvegicus Haffke, M., Jaakola, V.-P. 2.12 X-RAY DIFFRACTION 0.216 0.178 False True IGHV1 None None None None None 2kqn NA A 6 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6n32 H L 0 IMMUNE SYSTEM 11/14/18 Anti-HIV-1 Fab 2G12 re-refinement HOMO SAPIENS homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.227 0.198 False True unknown IGKV1 Kappa None None None None None 2a6k H L 0 P peptide dodecapeptide IMMUNE SYSTEM 07/03/05 Crystal Structure Analysis of the germline antibody 36-65 Fab in complex with the dodecapeptide SLGDNLTNHNLR MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M. 3.0 X-RAY DIFFRACTION 0.264 0.245 False False IGHV1 IGKV10 Kappa 2.0999999999999997e-07 -9.11012285753709 Unknown TBD 6hco D C 0 B protein atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/15/18 Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Kowal, J., Stahlberg, H., Locher, K.P. 3.58 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 7olz B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 05/20/21 Crystal structure of the SARS-CoV-2 RBD with neutralizing-VHHs Re5D06 and Re9F06 VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Guttler, T., Gorlich, D. 1.75 X-RAY DIFFRACTION 0.209 0.176 False True IGHV1 NA NA None None None None None 4qhm A B 0 IMMUNE SYSTEM 05/28/14 I3.1 (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.23 X-RAY DIFFRACTION 0.251 0.224 False True IGHV4 IGLV3 Lambda None None None None None 7mhz O P 0 A protein NA protein-cysteine n-palmitoyltransferase hhat TRANSFERASE/IMMUNE SYSTEM 04/16/21 Human Hedgehog acyltransferase (HHAT) in complex with a palmitoylated Hedgehog peptide product and a Fab antibody fragment HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Long, S.B., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV1 Kappa None None None None None 4r3s A B 0 Q peptide merozoite surface protein IMMUNE SYSTEM 08/18/14 Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 11-23 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S. 1.7 X-RAY DIFFRACTION 0.200 0.152 False True IGHV14 IGKV3 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 1mcj NA A 0 P peptide peptide n-acetyl-d-phe-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 7rbu H L 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 SARS-CoV-2 Spike in complex with PVI.V6-14 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Altomare, C.G., Bajic, G. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5mv4 I J 0 K peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 6hx4 H L 0 B protein alpha-1-antitrypsin PROTEIN BINDING 10/15/18 Fab fragment of a native monomer-selective antibody in complex with alpha-1-antitrypsin HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Elliston, E.L.K., Miranda, E., Perez, J., Jagger, A.M., Lomas, D.A., Irving, J.A. 2.95 X-RAY DIFFRACTION 0.277 0.231 False False IGHV5 IGKV3 Kappa None None None None None 3lrh NA A 0 B peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 1tji H L 0 P peptide envelope glycoprotein gp41 Viral protein/Immune system 06/04/04 Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 17mer epitope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Wyatt, R., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.221 0.183 False True IGHV2 IGKV1 Kappa None None None None None 6k2i A NA 14 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7wrv U V 0 C protein NA spike glycoprotein VIRAL PROTEIN 01/27/22 The interface of JMB2002 Fab binds to SARS-CoV-2 Omicron Variant S SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.47 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7cak I H 0 C protein NA spike glycoprotein VIRAL PROTEIN 06/08/20 SARS-CoV-2 S trimer with three RBD in the open state and complexed with three H014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4etq H L 0 C protein imv membrane protein IMMUNE SYSTEM/VIRAL PROTEIN 04/24/12 Vaccinia virus D8L IMV envelope protein in complex with Fab of murine IgG2a LA5 MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus Matho, M.H., Zajonc, D.M. 2.1 X-RAY DIFFRACTION 0.252 0.202 False True IGHV1 IGKV4 Kappa 1.8e-10 -13.29418688782641 SPR TBD 5vm4 G NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 1f4x H L 0 H Hapten MGS 1,2-O-DIMETHYL-4-[2,4-DIHYDROXY-BUTYRAMIDO]-4,6-DIDEOXY-ALPHA-D-MANNOPYRANOSIDE IMMUNE SYSTEM 06/10/00 CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN MUS MUSCULUS mus musculus mus musculus mus musculus Alzari, P.M., Souchon, H. 2.3 X-RAY DIFFRACTION 0.250 0.185 False False IGHV5 IGLV1 Lambda 2.56e-06 -7.62 Other 10880560 3chn B M 4 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 1ay1 H L 0 IMMUNOGLOBULIN 11/13/97 ANTI TAQ FAB TP7 MUS MUSCULUS mus musculus mus musculus Murali, R., Helmer-Citterich, M., Sharkey, D.J., Scalice, E.R., Daiss, J.L., Sullivan, M.A., Murthy, H.M.K. 2.2 X-RAY DIFFRACTION 0.288 0.196 False False IGHV3 IGKV4 Kappa None None None None None 7neg H L 0 E protein NA surface glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/04/21 Crystal structure of the N501Y mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.19 X-RAY DIFFRACTION 0.223 0.195 False True IGHV3 IGKV1 Kappa None None None None None 6c08 D E 0 F protein NA sodium-coupled neutral amino acid transporter 9 MEMBRANE PROTEIN 12/28/17 Zebrafish SLC38A9 with arginine bound in the cytosol open state DANIO RERIO; MUS MUSCULUS mus musculus mus musculus danio rerio Lei, H.-T., Gonen, T. 3.17 X-RAY DIFFRACTION 0.286 0.267 False False unknown unknown unknown None None None None None 6ek2 H h 0 A protein cd81 antigen CELL ADHESION 09/25/17 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 10 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Harris, S.F., Villasenor, A., Kuglstatter, A. 2.65 X-RAY DIFFRACTION 0.247 0.179 True True unknown unknown unknown None None None None None 7m6i H L 0 C | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, BG1-24 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6ca9 D C 0 IMMUNE SYSTEM 01/29/18 Crystal structure of Fab PCT64_LMCA (SAR), the least mutated common ancestor of the HIV-1 broadly neutralizing antibody lineage PCT64 HOMO SAPIENS homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 2.702 X-RAY DIFFRACTION 0.268 0.242 False True IGHV3 IGKV3 Kappa None None None None None 6qna E F 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV hybrid Fab B13HC-B4LC BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.62 X-RAY DIFFRACTION 0.250 0.220 False True IGHV1 IGLV1 Lambda None None None None None 4u05 A NA 0 NA NA NA NA IMMUNE SYSTEM 07/11/14 Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) S74A Variant LAMA GLAMA lama glama Legler, P.M. 2.5 X-RAY DIFFRACTION 0.239 0.209 False True IGHV1 NA NA None None None None None 6dc7 H L 0 IMMUNE SYSTEM 05/04/18 Apo Fab structure of mouse monoclonal antibody 8B2 MUS MUSCULUS mus musculus mus musculus Chukwu, J.E., Kong, X.-P. 1.901 X-RAY DIFFRACTION 0.235 0.183 False False IGHV1 IGKV1 Kappa None None None None None 7lyv A B 0 NA NA NA NA IMMUNE SYSTEM 03/08/21 Crystal structure of the HCMV pentamer-specific antibody 1-103 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., Jones, H.G., McLellan, J.S. 1.9 X-RAY DIFFRACTION 0.217 0.191 False True IGHV4 IGKV1 Kappa None None None None None 7luc H I 0 B protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/22/21 Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B RESPIRATORY SYNCYTIAL VIRUS; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus Wrapp, D., McLellan, J.S. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 3k1k C NA 0 A protein green fluorescent protein LUMINESCENT PROTEIN/IMMUNE SYSTEM 09/28/09 Green fluorescent protein bound to minimizer nanobody AEQUOREA VICTORIA; CAMELUS DROMEDARIUS lama pacos aequorea victoria Kirchhofer, A., Helma, J., Schmidthals, K., Frauer, C., Cui, S., Karcher, A., Pellis, M., Muyldermans, S., Delucci, C.C., Cardoso, M.C., Leonhardt, H., Hopfner, K.-P., Rothbauer, U. 2.15 X-RAY DIFFRACTION 0.255 0.212 False True IGHV1 None None None None None 6osy 5 6 0 2 protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 7lex F H 0 C protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7z1c D NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-B5 and H11-F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 1.9 X-RAY DIFFRACTION 0.199 0.175 False True IGHV1 NA NA None None None None None 7php K NA 0 NA NA NA NA MEMBRANE PROTEIN 08/18/21 Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM VIBRIO CHOLERAE RC385; SYNTHETIC CONSTRUCT; LAMA GLAMA lama glama Bloch, J.S., Mukherjee, S., Kowal, J., Niederer, M., Pardon, E., Steyaert, J., Kossiakoff, A.A., Locher, K.P. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4yue H L 0 C protein NA interleukin-2 CYTOKINE/IMMUNE SYSTEM 03/18/15 Mouse IL-2 Bound to S4B6 Fab Fragment MUS MUSCULUS mus musculus mus musculus mus musculus Spangler, J.B., Jude, K.M., Garcia, K.C. 2.194 X-RAY DIFFRACTION 0.231 0.203 False True IGHV1 IGKV12 Kappa None None None None None 6n1v Y a 0 B protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6pwc H L 0 A | R protein | protein NA | NA beta-arrestin-1 | neurotensin receptor type 1 SIGNALING PROTEIN 07/22/19 A complex structure of arrestin-2 bound to neurotensin receptor 1 HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens | homo sapiens Yin, W., Li, Z., Jin, M., Yin, Y.-L., de Waal, P.W., Pal, K., Gao, X., He, Y., Gao, J., Wang, X., Zhang, Y., Zhou, H., Melcher, K., Jiang, Y., Cong, Y., Zhou, X.E., Yu, X., Xu, H.E. 4.9 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6iyn A NA 11 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 4f2m C D 0 F protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/12 Crystal structure of a TGEV coronavirus Spike fragment in complex with the TGEV neutralizing monoclonal antibody 1AF10 TGEV VIRULENT PURDUE; MUS MUSCULUS mus musculus mus musculus tgev virulent purdue Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M. 3.0 X-RAY DIFFRACTION 0.251 0.216 False True IGHV1 IGKV5 Kappa None None None None None 7n3g H L 0 NA NA NA NA IMMUNE SYSTEM 06/01/21 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C098 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J., Barnes, C.O. 1.42 X-RAY DIFFRACTION 0.205 0.186 False True IGHV3 IGKV3 Kappa None None None None None 6qfa K NA 0 B protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 01/09/19 CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 HOMO SAPIENS; HELICOBACTER PYLORI (STRAIN G27); LAMA GLAMA helicobacter pylori (strain g27), lama glama homo sapiens Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkoening, A., Zoegg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6c6x E F 0 IMMUNE SYSTEM 01/19/18 Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque. MACACA MULATTA macaca mulatta macaca mulatta Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.208 0.176 False True IGHV4 IGKV1 Kappa None None None None None 4lvh K L 0 J protein hemagglutinin IMMUNE SYSTEM 07/26/13 Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J.-H. 2.8 X-RAY DIFFRACTION 0.274 0.232 False False IGHV5 IGKV3 Kappa None None None None None 6k7o F G 0 R protein NA leukocyte immunoglobulin-like receptor subfamily b member4 IMMUNE SYSTEM 06/08/19 Complex structure of LILRB4 and h128-3 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Song, H., Chai, Y., Xu, X., Gao, F.G. 3.004 X-RAY DIFFRACTION 0.270 0.228 False True IGHV3 IGKV1 Kappa None None None None None 6bf4 H L 0 G protein hiv-1 clade ae gp120 core viral protein/immune system 10/25/17 Crystal Structure of HIV-1 Clade AE Strain CNE55 gp120 Core in Complex with Neutralizing Antibody VRC-PG05 that Targets the Center of the Silent Face on the Outer Domain of gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.382 X-RAY DIFFRACTION 0.228 0.192 False True IGHV3 IGKV4 Kappa 1.78e-07 -9.20807461785177 SPR TBD 7e33 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/07/21 Serotonin 1E (5-HT1E) receptor-Gi protein complex HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI mus musculus homo sapiens | homo sapiens Xu, P., Huang, S., Zhang, H., Mao, C., Zhou, X.E., Shen, D.D., Jiang, Y., Zhang, Y., Xu, H.E. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7tn0 C D 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/20/22 SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., McCallum, M., Veesler, D., Nix, J.C., Croll, T.I., Dillen, J.R., Czudnochowski, N. 2.85 X-RAY DIFFRACTION 0.268 0.230 False True IGHV1 IGKV3 Kappa None None None None None 6hjp I J 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/04/18 Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76) in complex with FISW84 Fab Fragment HOMO SAPIENS; INFLUENZA A VIRUS (STRAIN A/DUCK/ALBERTA/35/1976 H1N1) homo sapiens homo sapiens influenza a virus (straina/duck/alberta/35/1976 h1n1) | influenza a virus (straina/duck/alberta/35/1976 h1n1) Benton, D.J., Rosenthal, P.B. 3.3 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 5tz2 H L 0 C protein leukocyte surface antigen cd47 IMMUNE SYSTEM 11/21/16 Crystal structure of human CD47 ECD bound to Fab of C47B222 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cardoso, R.M.F. 2.302 X-RAY DIFFRACTION 0.255 0.201 False True IGHV5 IGKV3 Kappa 1.1200000000000003e-09 -12.211051408172032 SPR TBD 6ieq D E 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN 09/16/18 Crystal Structure of HIV-1 Env ConM SOSIP.v7 in Complex with bNAb PGT124 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Han, B.W., Wilson, I.A. 3.9 X-RAY DIFFRACTION 0.296 0.247 False True unknown unknown unknown None None None None None 6hjp K L 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/04/18 Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76) in complex with FISW84 Fab Fragment HOMO SAPIENS; INFLUENZA A VIRUS (STRAIN A/DUCK/ALBERTA/35/1976 H1N1) homo sapiens homo sapiens influenza a virus (straina/duck/alberta/35/1976 h1n1) | influenza a virus (straina/duck/alberta/35/1976 h1n1) Benton, D.J., Rosenthal, P.B. 3.3 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 2esg B M 0 IMMUNE SYSTEM/TRANSPORT PROTEIN 10/26/05 Solution structure of the complex between immunoglobulin IgA1 and human serum albumin HOMO SAPIENS homo sapiens homo sapiens Almogren, A., Furtado, P.B., Sun, Z., Perkins, S.J., Kerr, M.A. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 2kh2 B b 68 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 3whe M N 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 6muf H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/23/18 Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.4 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.91 X-RAY DIFFRACTION 0.297 0.253 False True IGHV4 unknown unknown None None None None None 7d5z P O 0 M protein NA envelope glycoprotein h VIRAL PROTEIN 09/28/20 Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8 HUMAN GAMMAHERPESVIRUS 4; HOMO SAPIENS homo sapiens homo sapiens human gammaherpesvirus 4 Zhu, Q., Shan, S., Yu, J., Wang, X., Zhang, L., Zeng, M. 4.2 X-RAY DIFFRACTION 0.277 0.246 False True IGHV3 IGKV1 Kappa None None None None None 3mac H L 0 A protein transmembrane glycoprotein IMMUNE SYSTEM 03/23/10 crystal structure of GP41-derived protein complexed with fab 8062 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Li, M., Gustchina, E., Louis, J., Gustchina, A., Wlodawer, A., Clore, M. 2.5 X-RAY DIFFRACTION 0.264 0.200 False True IGHV1 IGLV3 Lambda 2.00E-07 -9.23 ITC 28 21085615 5yoy P M 0 K protein tumor necrosis factor IMMUNE SYSTEM 10/31/17 Crystal structure of the human tumor necrosis factor in complex with golimumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N. 2.727 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV3 Kappa 1.8e-11 -14.658430977236662 Unknown TBD 6qcu H L 0 IMMUNE SYSTEM 12/31/18 Crystal structure of a Fab portion of the anti EBOV 3T0331 antibody HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Cohen-Dvashi, H. 1.56 X-RAY DIFFRACTION 0.203 0.176 False True IGHV3 IGKV3 Kappa None None None None None 6nfj B NA 0 A protein beta-klotho SIGNALING PROTEIN 12/20/18 Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens Kuzina, E., Schlessinger, J., Lee, S. 3.19 X-RAY DIFFRACTION 0.320 0.280 False True IGHV1 None None None None None 7so7 H L 0 A protein NA toxin b TOXIN/IMMUNE SYSTEM 10/29/21 Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B CLOSTRIDIOIDES DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens clostridioides difficile Liu, J. 3.59 X-RAY DIFFRACTION 0.258 0.209 False True IGHV3 IGLV5 Lambda None None None None None 5w9k H I 0 G protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.6 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 4evn I J 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 5wob U V 0 G protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 3h42 H L 0 B | A protein | protein NA | NA proprotein convertase subtilisin/kexin type 9 | proprotein convertase subtilisin/kexin type 9 HYDROLASE/IMMUNE SYSTEM 04/17/09 Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T., Tsai, M.M., Yang, E. 2.3 X-RAY DIFFRACTION 0.209 0.191 False True IGHV3 IGLV1 Lambda 4.00E-12 -15.54 Other 25 19443683 6ot0 H L 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 05/02/19 Structure of human Smoothened-Gi complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Qi, X., Li, X. 3.9 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 1f2x L NA 0 IMMUNE SYSTEM 05/30/00 STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05 CAMELUS DROMEDARIUS camelus dromedarius Decanniere, K., Muyldermans, S., Wyns, L. 2.1 X-RAY DIFFRACTION 0.270 0.190 False True IGHV1 None None None None None 2exw C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 11/09/05 Crystal structure of a EcClC-Fab complex in the absence of bound ions ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lobet, S., Dutzler, R. 3.2 X-RAY DIFFRACTION 0.314 0.268 False False IGHV4 IGKV4 Kappa None None None None None 4rrp L F 0 R protein antigen asf1p IMMUNE SYSTEM 11/06/14 Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Kuzin, A., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Oconnell, P.T., Maglaqui, M., Bailey, L., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG) 2.79 X-RAY DIFFRACTION 0.253 0.183 False True IGHV3 IGKV1 Kappa None None None None None 4ptt B A 0 IMMUNE SYSTEM 03/11/14 Crystal Structure of anti-23F strep Fab C05 HOMO SAPIENS homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Smith, K., Schrader, J.W., Pai, E.F. 1.8 X-RAY DIFFRACTION 0.196 0.171 False True IGHV3 IGKV3 Kappa None None None None None 6x8q H L 0 P peptide NA papp peptide IMMUNE SYSTEM 06/01/20 Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein PAPP peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium berghei anka Thai, E., Julien, J.P. 1.6 X-RAY DIFFRACTION 0.188 0.159 False True IGHV1 IGKV1 Kappa None None None None None 3s36 H L 0 X protein vascular endothelial growth factor receptor 2 IMMUNE SYSTEM/Transferase 05/17/11 Structural basis for the function of two anti-VEGF receptor antibodies MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Franklin, M.C. 3.2 X-RAY DIFFRACTION 0.332 0.274 False True IGHV3 IGKV1 Kappa None None None None None 3r06 D C 0 IMMUNE SYSTEM 03/07/11 Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius Shore, D.A., Zhu, X., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.191 False True IGHV5 IGKV14 Kappa None None None None None 1hez D C 0 E protein protein l ANTIBODY 11/27/00 antibody-antigen complex HOMO SAPIENS; FINEGOLDIA MAGNA homo sapiens homo sapiens finegoldia magna Graille, M., Stura, E.A., Housden, N.G., Bottomley, S.P., Taussig, M.J., Sutton, B.J., Gore, M.G., Charbonnier, JB. 2.7 X-RAY DIFFRACTION 0.278 0.215 False False IGHV3 IGKV1 Kappa 1.45e-07 -9.32 Other 25 11587642 1nj9 H L 0 IMMUNE SYSTEM 12/30/02 Cocaine hydrolytic antibody 15A10 MUS MUSCULUS mus musculus mus musculus Larsen, N.A., de Prada, P., Deng, S.X., Zhu, X., Landry, D.W., Wilson, I.A. 2.35 X-RAY DIFFRACTION 0.283 0.199 False False IGHV1 IGLV1 Lambda None None None None None 6pt0 E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/14/19 Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Xu, T.H., Xing, C., Zhuang, Y., Feng, Z., Zhou, X.E., Chen, M., Wang, L., Meng, X., Xue, Y., Wang, J., Liu, H., McGuire, T., Zhao, G., Melcher, K., Zhang, C., Xu, H.E., Xie, X.Q. 3.2 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 7epx H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/28/21 S protein of SARS-CoV-2 in complex with GW01 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shen, Y.P., Zhang, Y.Y., Yan, R.H., Li, Y.N., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7l5j Y X 0 A protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 12/22/20 Mouse Norovirus Protruding domain complexed with neutralizing Fab fragment from mAb A6.2 MURINE NOROVIRUS 1; MUS MUSCULUS mus musculus mus musculus murine norovirus 1 Smith, T.J., Sherman, M.B. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV4 Kappa None None None None None 6azx C D 0 IMMUNE SYSTEM 09/13/17 Crystal structure of the neutralizing anti-circumsporozoite protein 663 antibody HOMO SAPIENS homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.238 0.206 False True IGHV3 IGKV2 Kappa None None None None None 4jha H L 0 IMMUNE SYSTEM 03/04/13 Crystal Structure of RSV-Neutralizing Human Antibody D25 HOMO SAPIENS homo sapiens homo sapiens Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S. 1.6 X-RAY DIFFRACTION 0.255 0.240 False True IGHV1 IGKV1 Kappa None None None None None 7jln H L 0 NA NA NA NA IMMUNE SYSTEM 07/30/20 Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 2.57 X-RAY DIFFRACTION 0.256 0.197 False True IGHV1 IGKV3 Kappa None None None None None 4fqh H L 0 IMMUNE SYSTEM 06/25/12 Crystal Structure of Fab CR9114 HOMO SAPIENS homo sapiens homo sapiens Dreyfus, C., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGLV1 Lambda None None None None None 6qpg M NA 0 A | B protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit RNA BINDING PROTEIN 02/13/19 Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205 INFLUENZA A VIRUS (STRAIN A/NORTHERN TERRITORY/60/1968 H3N2); CAMELIDAE camelidae influenza a virus (strain a/northernterritory/60/1968 h3n2) | influenza a virus (strain a/northernterritory/60/1968 h3n2) Fan, H.T., Keown, J.R., Fodor, E., Grimes, J.M. 3.34 X-RAY DIFFRACTION 0.305 0.251 False True IGHV3 NA NA None None None None None 7wic S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 01/03/22 Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Chen, L., Wang, W., Dong, Y., Shen, D., Guo, J., Qin, J., Zhang, H., Shen, Q., Zhang, Y., Mao, C. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7cw3 q r 0 F | E protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG (subregion around icosahedral 2-fold vertex) CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 9.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 7kgu F E 0 NA NA NA NA IMMUNE SYSTEM 10/18/20 Structure of 2Q1-Fab, an antibody selective for IDH2R140Q-HLA-B*07:02 HOMO SAPIENS homo sapiens homo sapiens Miller, M.S., Aytenfisu, T.Y., Wright, K.M., Gabelli, S.B. 2.4 X-RAY DIFFRACTION 0.269 0.208 False True IGHV3 IGKV1 Kappa None None None None None 7a3o H L 0 A protein NA core protein VIRAL PROTEIN 08/18/20 Crystal structure of dengue 1 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10 DENGUE VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens dengue virus 1 Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 2.8 X-RAY DIFFRACTION 0.268 0.218 False True IGHV1 IGLV2 Lambda None None None None None 1jgl H L 0 L Hapten EST ESTRADIOL IMMUNE SYSTEM 06/26/01 Crystal structure of immunoglobulin Fab fragment complexed with 17-beta-estradiol MUS MUSCULUS mus musculus mus musculus mus musculus Lamminmaki, U., Kankare, J.A. 2.15 X-RAY DIFFRACTION 0.249 0.199 False True IGHV9 IGKV12 Kappa 2e-09 -11.867518412372508 Unknown TBD 3u9p H L 0 D protein neutrophil gelatinase-associated lipocalin IMMUNE SYSTEM 10/19/11 Crystal Structure of Murine Siderocalin in Complex with an Fab Fragment MUS MUSCULUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Correnti, C., Strong, R.K. 2.8 X-RAY DIFFRACTION 0.292 0.219 False True IGHV2 IGKV19 Kappa None None None None None 3mlr H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a NY5 V3 peptide HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 Kong, X.-P. 1.8 X-RAY DIFFRACTION 0.216 0.181 False False IGHV5 IGLV3 Lambda None None None None None 5mvj E F 0 IMMUNE SYSTEM 01/16/17 Structure of DC8E8 Fab at pH 6.5 crystallized in space-group P1 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.5 X-RAY DIFFRACTION 0.272 0.219 False False IGHV1 IGKV8 Kappa None None None None None 5eoc J M 0 Q peptide ala-cys-gln-leu-ile-asn-thr-asn-gly-ser-trp-his-ile-cys IMMUNE SYSTEM 11/10/15 Crystal structure of Fab C2 in complex with a Cyclic variant of Hepatitis C Virus E2 epitope I MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Berisio, R., Ruggiero, A., Sandomenico, A., Patel, A.H., Ruvo, M., Vitagliano, L. 1.98 X-RAY DIFFRACTION 0.266 0.234 False False IGHV1 IGKV3 Kappa 3.03e-08 -10.257147454957629 Unknown TBD 6icc H L 0 A protein pdz tandem fragment with pa tag SIGNALING PROTEIN 09/05/18 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA12 tag inserted between the residues 181 and 186 AQUIFEX AEOLICUS VF5; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus aquifex aeolicus vf5 Tamura, R., Oi, R., Kaneko, M.K., Kato, Y., Nogi, T. 2.0 X-RAY DIFFRACTION 0.260 0.213 False True IGHV5 IGLV3 Lambda None None None None None 6e4x Z Y 0 B protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/18/18 Human antibody S5V2-29 in complex with influenza hemagglutinin A/Texas/50/2012 (H3N2) INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 2.25 X-RAY DIFFRACTION 0.225 0.203 False True IGHV4 IGKV1 Kappa None None None None None 5ujz I i 0 E protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 1 HOMO SAPIENS; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 1hil B A 0 IMMUNOGLOBULIN 07/08/92 STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIGEN-ANTIBODY RECOGNITION MUS MUSCULUS mus musculus mus musculus Rini, J.M., Wilson, I.A. 2.0 X-RAY DIFFRACTION unknown 0.195 False False IGHV5 IGKV8 Kappa None None None None None 7dcc D H 0 E protein NA spike glycoprotein VIRAL PROTEIN 10/24/20 S-3C1-F3b structure, all the three RBDs are in the up conformation and each of them associates with a 3C1 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 4.3 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 6k5f C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/28/19 Crystal structure of the CLC-ec1 deltaNC in presence of 200 mM NaBr ESCHERICHIA COLI; MUS MUSCULUS mus musculus escherichia coli Park, K., Lim, H.H. 3.203 X-RAY DIFFRACTION 0.300 0.236 False True IGHV4 IGKV4 Kappa None None None None None 6xpz B C 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S1V2-83 in complex with the influenza hemagglutinin head domain of A/Moscow/10/1999(H3N2) INFLUENZA A VIRUS (A/MOSCOW/10/1999(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/moscow/10/1999(h3n2)) McCarthy, K.R., Harrison, S.C. 3.45 X-RAY DIFFRACTION 0.307 0.251 False True IGHV3 IGKV1 Kappa None None None None None 7tca H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 6jri E NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 7a4d J NA 0 K peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 5jop E D 0 A carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 05/02/16 Crystal structure of anti-glycan antibody Fab14.22 in complex with Streptococcus pneumoniae serotype 14 tetrasaccharide at 1.75 A MUS MUSCULUS mus musculus mus musculus Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.200 0.165 False True IGHV1 IGKV1 Kappa None None None None None 6raj C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing open conformation THERMUS THERMOPHILUS HB27; THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 3.5 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6dez B A 0 IMMUNE SYSTEM 05/13/18 Anti-phosphotyrosine antibody PY20-4D5 Fab complexed with sulfate SYNTHETIC CONSTRUCT synthetic construct synthetic construct Mou, K., Leung, K., Wells, J.A. 3.2 X-RAY DIFFRACTION 0.296 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7mem H L 0 E protein NA hemagglutinin ha1 chain Viral protein/IMMUNE SYSTEM 04/06/21 CryoEM structure of monoclonal Fab 045-09 2B05 binding the lateral patch of influenza virus H1 HA INFLUENZA A VIRUS (STRAIN SWL A/CALIFORNIA/04/2009 H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain swla/california/04/2009 h1n1) Han, J., Ward, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1mak NA A 3 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 3mls J N 0 R peptide rationally designed v3 mimotope IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.-P. 2.5 X-RAY DIFFRACTION 0.274 0.216 False False IGHV5 IGLV3 Lambda None None None None None 4jfy B A 0 immune system 02/28/13 Apo structure of phosphotyrosine (pYAb) scaffold ESCHERICHIA COLI Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 2.63 X-RAY DIFFRACTION 0.236 0.188 False True IGHV3 IGKV3 Kappa None None None None None 5ugy I M 0 C protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/10/17 Influenza hemagglutinin in complex with a neutralizing antibody INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Whittle, J.R.R., Jenni, S., Harrison, S.C. 2.801 X-RAY DIFFRACTION 0.289 0.259 False True IGHV1 IGLV3 Lambda None None None None None 1zv5 A NA 0 L protein lysozyme c HYDROLASE/IMMUNE SYSTEM 06/01/05 Crystal structure of the variable domain of the camelid heavy-chain antibody D2-L29 in complex with hen egg white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., Wyns, L. 2.0 X-RAY DIFFRACTION 0.239 0.217 False True IGHV1 1.00e-08 -10.91 SPR 16537393 7chf H L 0 R protein NA sars-cov-2 receptor binding domain ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 RBD in complex with BD-604 Fab and BD-368-2 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J., Zhu, Q. 2.674 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV1 Kappa None None None None None 4gxu M N 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/04/12 Crystal structure of antibody 1F1 bound to the 1918 influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 3.294 X-RAY DIFFRACTION 0.255 0.219 False True IGHV3 IGLV1 Lambda 6.24e-09 SPR 23236279 7v6a S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/20/21 Cry-EM structure of M4-c110-G protein complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Wang, J.J., Wu, M., Wu, L.J., Hua, T., Liu, Z.J., Wang, T. 3.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ki1 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 10/22/20 Taspoglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs Protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens | homo sapiens Zhang, X., Belousoff, M.J., Danev, R., Sexton, P.M., Wootten, D. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1mf2 N M 0 IMMUNOGLOBULIN 12/27/96 ANTI HIV1 PROTEASE FAB COMPLEX MUS MUSCULUS mus musculus mus musculus Lescar, J., Bentley, G.A. 2.6 X-RAY DIFFRACTION 0.307 0.206 False False IGHV5 IGKV3 Kappa None None None None None 5wob S T 0 F protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 7cmu E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/29/20 Dopamine Receptor D3R-Gi-Pramipexole complex HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI mus musculus homo sapiens | homo sapiens Xu, P., Huang, S., Mao, C., Krumm, B., Zhou, X., Tan, Y., Huang, X.-P., Liu, Y., Shen, D.-D., Jiang, Y., Yu, X., Jiang, H., Melcher, K., Roth, B., Cheng, X., Zhang, Y., Xu, H. 3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4xh2 A B 0 a peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD4 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.0 X-RAY DIFFRACTION 0.258 0.224 False True IGHV3 IGKV1 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 6waq C NA 0 D protein spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/25/20 Crystal structure of the SARS-CoV-1 RBD bound by the cross-reactive single-domain antibody SARS VHH-72 LAMA GLAMA; HUMAN SARS CORONAVIRUS lama glama human sars coronavirus Wrapp, D., McLellan, J.S. 2.2 X-RAY DIFFRACTION 0.236 0.203 False True IGHV1 None None None None None 4f33 F E 0 IMMUNE SYSTEM 05/08/12 Crystal Structure of therapeutic antibody MORAb-009 MUS MUSCULUS Xia, D., Ma, J., Tang, W.K., Esser, L. 1.749 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 IGKV4 Kappa None None None None None 7r4q E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/09/22 The SARS-CoV-2 spike in complex with the 1.29 neutralizing nanobody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Melero, R., Arranz, R., Fernandez, L.A. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6qfa N NA 0 E protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 01/09/19 CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 HOMO SAPIENS; HELICOBACTER PYLORI (STRAIN G27); LAMA GLAMA helicobacter pylori (strain g27), lama glama homo sapiens Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkoening, A., Zoegg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6peh H L 0 IMMUNE SYSTEM 06/20/19 Crystal structure of rabbit monoclonal anti-HIV antibody 1C2 HOMO SAPIENS homo sapiens homo sapiens Liban, T., Pancera, M. 2.296 X-RAY DIFFRACTION 0.255 0.219 False True IGHV1 IGKV1 Kappa None None None None None 4r7n E F 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 1uz6 H L 0 IMMUNE SYSTEM 03/05/04 anti-Lewis X Fab fragment uncomplexed MUS MUSCULUS mus musculus mus musculus Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P. 2.05 X-RAY DIFFRACTION 0.244 0.198 False False IGHV4 IGKV2 Kappa None None None None None 6h06 H L 0 I peptide microtubule-associated protein tau IMMUNE SYSTEM 07/06/18 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Juraszek, J., Steinbacher, S. 2.63 X-RAY DIFFRACTION 0.270 0.216 False True IGHV1 IGKV2 Kappa 5.6e-06 -7.164753442850797 Unknown TBD 6cxc G J 0 B | A protein | protein NA | NA fusion glycoprotein f0, envelope glycoprotein chimera | fusion glycoprotein f0, envelope glycoprotein chimera VIRAL PROTEIN/IMMUNE SYSTEM 04/02/18 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus fusion protein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN IMMUNODEFICIENCY VIRUS 1 mus musculus mus musculus human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 | human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Xie, Q., Wang, Z., Chen, X., Ni, F., Ma, J., Wang, Q. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7cwt N K 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike protein in complex with hb27 and fc05 Fab cocktail SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cui, Z., Wang, X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7lez R P 0 N protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7ws5 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7d9z H L 0 NA NA NA NA IMMUNE SYSTEM 10/14/20 Crystal structure of anti-basigin Fab fragment ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Sakuragi, T., Kanai, R., Narita, H., Onishi, E., Miyazaki, T., Baba, T., Nakagawa, A., Toyoshima, C., Nagata, S. 1.123 X-RAY DIFFRACTION 0.150 0.121 False True IGHV1 IGKV1 Kappa None None None None None 2qtj B M 5 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7omn B NA 0 NA NA NA NA IMMUNE SYSTEM 05/24/21 Anti-EphA1 JD1-1 VH domain HOMO SAPIENS homo sapiens Ereno Orbea, J., Nilvebrant, J., Sidhu, S., Julien, J.P. 1.7 X-RAY DIFFRACTION 0.222 0.203 False True IGHV3 NA NA None None None None None 4xbg H L 0 H Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 12/16/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA): 2.73 A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGKV3 Kappa None None None None None 5mhr K J 0 C protein NA viral attachment protein sigma 1 IMMUNE SYSTEM 11/25/16 T3D reovirus sigma1 complexed with 9BG5 Fab fragments REOVIRUS SP.; MUS MUSCULUS mus musculus mus musculus reovirus sp. Stehle, T., Dietrich, M.H. 3.0 X-RAY DIFFRACTION 0.247 0.212 False False IGHV1 IGKV4 Kappa None None None None None 5o6v H L 0 B protein genome polyprotein VIRUS 06/07/17 The cryo-EM structure of Tick-borne encephalitis virus complexed with Fab fragment of neutralizing antibody 19/1786 TICK-BORNE ENCEPHALITIS VIRUS (STRAIN HYPR); MUS MUSCULUS mus musculus mus musculus tick-borne encephalitis virus (strain hypr) Fuzik, T., Plevka, P. 3.9, 3.9 ELECTRON MICROSCOPY False False IGHV5 IGKV6 Kappa None None None None None 6c5j H L 0 H carbohydrate GP1 polysaccharide IMMUNE SYSTEM, SUGAR BINDING PROTEIN 01/16/18 S25-23 Fab in complex with Chlamydiaceae LPS (Crystal form 1) MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.29 X-RAY DIFFRACTION 0.239 0.193 False False IGHV2 IGKV1 Kappa None None None None None 5yd4 E e 0 F peptide epitope peptide (mutation t6a) IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide (mutation T6A) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.173 0.135 True True unknown unknown unknown None None None None None 3lzf H L 0 A protein hemagglutinin, ha1 subunit VIRAL PROTEIN/IMMUNE SYSTEM 03/01/10 Crystal Structure of Fab 2D1 in Complex with the 1918 Influenza Virus Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.259 0.230 False True IGHV2 IGLV1 Lambda None None None None None 4mqx C D 0 A protein h(+)/cl(-) exchange transporter clca metal transport, membrane protein 09/16/13 CLC-ec1 Fab Complex Cysless A399C-A432C mutant ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Basilio, D., Noack, K., Picollo, A., Accardi, A. 3.516 X-RAY DIFFRACTION 0.258 0.223 False True IGHV4 IGKV4 Kappa None None None None None 5t3s D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM 08/26/16 HIV gp140 trimer MD39-10MUTA in complex with Fabs PGT124 and 35022 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Stanfield, R.L., Wilson, I.A. 4.5 X-RAY DIFFRACTION 0.309 0.270 False True unknown unknown unknown None None None None None 6k3m NA A 0 H protein spa igg-binding domain protein,protein a STRUCTURAL PROTEIN 05/20/19 Application of anti-helix antibodies in protein structure determination (8189-3LRH) STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.8 X-RAY DIFFRACTION 0.231 0.190 False True IGLV1 Lambda None None None None None 5mhe H L 0 H Hapten T44 3,5,3',5'-TETRAIODO-L-THYRONINE IMMUNE SYSTEM 11/24/16 Crystal structure of anti-T4 Fab fragment with T4 MUS MUSCULUS mus musculus mus musculus mus musculus Parkkinen, T., Rouvinen, J. 1.9 X-RAY DIFFRACTION 0.227 0.178 False True IGHV5 IGKV4 Kappa None None None None None 5j75 B b 0 b Hapten 6GQ N,4-dimethyl-N-{2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl]ethyl}benzene-1-sulfonamide IMMUNE SYSTEM 04/05/16 Fluorogen Activating Progein AM2.2 in complex with ML342 HOMO SAPIENS homo sapiens Stanfield, R.L., Wilson, I.A., Wu, Y. 2.0 X-RAY DIFFRACTION 0.263 0.221 True True unknown unknown unknown None None None None None 3mls I M 0 Q peptide rationally designed v3 mimotope IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.-P. 2.5 X-RAY DIFFRACTION 0.274 0.216 False False IGHV5 IGLV3 Lambda None None None None None 7cgw A B 0 C protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 07/02/20 Complex structure of PD-1 and tislelizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hong, Y., Feng, Y.C., Liu, Y. 3.2 X-RAY DIFFRACTION 0.254 0.218 False True IGHV4 IGKV4 Kappa None None None None None 6qf9 B b 0 APOPTOSIS 01/09/19 Structure of an anti-Mcl1 scFv HOMO SAPIENS homo sapiens Luptak, J. 1.43 X-RAY DIFFRACTION 0.216 0.185 True True unknown unknown unknown None None None None None 4f9l c C 0 B protein butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 05/18/12 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 20.1 Single Chain Antibody HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Palakodeti, A., Sandstrom, A., Sundaresan, L., Harly, C., Nedellec, S., Olive, D., Scotet, E., Bonneville, M., Adams, E.J. 3.1404 X-RAY DIFFRACTION 0.303 0.254 True True unknown unknown unknown 6.600000000000001e-08 -9.795894745207022 SPR TBD 1ots E F 0 B protein voltage-gated clc-type chloride channel eric MEMBRANE PROTEIN 03/22/03 Structure of the Escherichia coli ClC Chloride channel and Fab Complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Dutzler, R., Campbell, E.B., MacKinnon, R. 2.51 X-RAY DIFFRACTION 0.299 0.264 False False IGHV4 IGKV4 Kappa None None None None None 4rbp M K 0 M carbohydrate KDO polysaccharide IMMUNE SYSTEM 09/12/14 Crystal structure of HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomanose HOMO SAPIENS homo sapiens homo sapiens homo sapiens Stanfield, R.L., Wilson, I.A., De Castro, C., Marzaioli, A.M., Pantophlet, R. 1.85 X-RAY DIFFRACTION 0.252 0.208 False False IGHV3 IGKV1 Kappa None None None None None 5o1r H L 0 A protein gna2132 IMMUNE SYSTEM 05/19/17 human Fab 5H2 bound to NHBA-C3 from Neisseria meningitidis serogroup B NEISSERIA MENINGITIDIS; HOMO SAPIENS homo sapiens homo sapiens neisseria meningitidis Enrico, M., Maritan, M. 2.86 X-RAY DIFFRACTION 0.222 0.178 False True IGHV4 IGKV1 Kappa None None None None None 2mmx NA A 9 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 3dwt B NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 3eot H L 0 IMMUNE SYSTEM 09/29/08 Crystal structure of LAC031, an engineered anti-VLA1 Fab MUS MUSCULUS mus musculus mus musculus Boriack-Sjodin, P.A., Clark, L.A. 1.9 X-RAY DIFFRACTION 0.270 0.234 False True IGHV5 IGKV4 Kappa None None None None None 6y6c C c 0 B protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 02/26/20 TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Williams, E., Mukhopadhyay, S.M.M., McKinley, G., Gruslund, S., Wigren, E., Persson, H., Arrowsmith, C.H., Edwards, A., von Delft, F., Bountra, C., Davis, J.B., Di Daniel, E., Burgess-Brown, N., Bullock, A. 2.26 X-RAY DIFFRACTION 0.216 0.191 True True unknown unknown unknown None None None None None 6t2j A NA 0 IMMUNE SYSTEM 10/08/19 dAb3 SYNTHETIC CONSTRUCT synthetic construct Tsai, Y.-C.I., House, D., Rittinger, K. 1.7 X-RAY DIFFRACTION 0.208 0.175 False True IGHV3 None None None None None 6k7o H L 0 A protein NA leukocyte immunoglobulin-like receptor subfamily b member4 IMMUNE SYSTEM 06/08/19 Complex structure of LILRB4 and h128-3 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Song, H., Chai, Y., Xu, X., Gao, F.G. 3.004 X-RAY DIFFRACTION 0.270 0.228 False True IGHV3 IGKV1 Kappa None None None None None 6t3j C D 0 E protein NA tumor necrosis factor receptor superfamily member 10b APOPTOSIS 10/11/19 Dual Epitope Targeting by Anti-DR5 Antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tauchert, M.J., Augustin, M., Krapp, S., Overdijk, M.B., Breij, E.C.W., Hibbert, R.G. 3.05 X-RAY DIFFRACTION 0.282 0.251 False True IGHV1 IGKV1 Kappa None None None None None 7lxz E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2L28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7l77 H L 0 NA NA NA NA IMMUNE SYSTEM 12/27/20 Crystal structure of broadly HIV-1-neutralizing antibody VRC33.01 HOMO SAPIENS homo sapiens homo sapiens Zhou, T., Kwong, P.D. 1.543 X-RAY DIFFRACTION 0.187 0.152 False True IGHV4 IGKV1 Kappa None None None None None 7t4s H I 0 D | B protein | protein NA | NA envelope glycoprotein ul130 | envelope glycoprotein l VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11 HUMAN BETAHERPESVIRUS 5; HOMO SAPIENS homo sapiens homo sapiens human betaherpesvirus 5 | human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7czp J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P2B-1A1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 6vn1 J N 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/29/20 A 2.8 Angstrom Cryo-EM Structure of a Glycoprotein B-Neutralizing Antibody Complex Reveals a Critical Domain for Herpesvirus Fusion Initiation HOMO SAPIENS; HUMAN ALPHAHERPESVIRUS 3 homo sapiens homo sapiens human alphaherpesvirus 3 Oliver, S.L. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 2mmx NA A 0 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 2kqn NA B 0 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5wl2 H L 0 ANTIVIRAL PROTEIN 07/25/17 VH1-69 germline antibody with CDR H3 sequence of CR9114 HOMO SAPIENS homo sapiens homo sapiens Wilson, I.A., Lang, S. 2.0 X-RAY DIFFRACTION 0.236 0.200 False True IGHV1 IGLV1 Lambda None None None None None 5hbt D C 0 B protein acetylcholine receptor subunit alpha 1 TRANSPORT PROTEIN/TOXIN 01/02/16 Complex structure of Fab35 and human nAChR alpha1 HOMO SAPIENS; RATTUS NORVEGICUS; BUNGARUS MULTICINCTUS rattus norvegicus rattus norvegicus homo sapiens Noridomi, K., Watanabe, G., Hansen, M.N., Han, G.W., Chen, L. 2.61 X-RAY DIFFRACTION 0.260 0.207 False False IGHV2 IGKV22 Kappa None None None None None 1hq4 D C 0 immune system 12/14/00 STRUCTURE OF NATIVE CATALYTIC ANTIBODY HA5-19A4 MUS MUSCULUS mus musculus mus musculus Paschall, C.M., Hasserodt, J., Lerner, R.A., Janda, K.D., Christianson, D.W. 2.7 X-RAY DIFFRACTION 0.265 0.225 False False IGHV3 IGKV4 Kappa None None None None None 3gjf H L 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a-2alpha chain | nyeso-1 peptide IMMUNE SYSTEM 03/08/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E., Kleber, S., Stenner-Liewen, F., Bauer, S., McMichael, A., Knuth, A., Abken, H., Hombach, A.A., Cerundolo, V., Jones, E.Y., Renner, C. 1.9 X-RAY DIFFRACTION 0.251 0.202 False True IGHV3 IGLV2 Lambda 6.30e-08 -9.82 SPR 19307587 2vl5 C D 0 IMMUNE SYSTEM 01/08/08 Structure of anti-collagen type II FAb CIIC1 MUS MUSCULUS mus musculus mus musculus Uysal, H., Sehnert, B., Nandakumar, K.S., Boiers, U., Burkhardt, H., Holmdahl, R., Thunnissen, M.M. 2.1 X-RAY DIFFRACTION 0.289 0.212 False False IGHV1 IGKV3 Kappa None None None None None 7m2h A B 0 C protein NA ph-gated potassium channel kcsa TRANSPORT PROTEIN/IMMUNE SYSTEM 03/16/21 Structural Snapshots of Intermediates in the Gating of a K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Reddi, R., Valiyaveetil, F.I. 2.642 X-RAY DIFFRACTION 0.268 0.237 False True IGHV1 IGKV5 Kappa None None None None None 6b0h D C 0 I protein pfs25 IMMUNE SYSTEM 09/14/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1262 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum McLeod, B., Scally, S.W., Bosch, A., King, C.R., Julien, J.P. 2.7 X-RAY DIFFRACTION 0.238 0.186 False True IGHV4 IGKV1 Kappa None None None None None 7nmu C NA 0 A protein NA unknown BLOOD CLOTTING 02/23/21 Crystal structure of human platelet glycoprotein VI in complex with an inhibitory nanobody. HOMO SAPIENS; LAMA GLAMA Slater, A., Jonas, E., Watson, S.P. 2.5 X-RAY DIFFRACTION 0.235 0.174 False False IGHV1 NA NA None None None None None 4xp9 H L 0 C protein dopamine transporter transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter bound to psychostimulant D-amphetamine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Aravind, P., Wang, K., Gouaux, E. 2.8 X-RAY DIFFRACTION 0.242 0.211 False True IGHV5 IGKV4 Kappa None None None None None 5vm4 D NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 7uds D E 0 B | b protein | protein NA | NA glycoprotein g2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 03/20/22 Structure of lineage I (Pinneo) Lassa virus glycoprotein bound to Fab 25.10C HOMO SAPIENS; LASSA MAMMARENAVIRUS homo sapiens homo sapiens lassa mammarenavirus | lassa mammarenavirus Buck, T.K., Enriquez, A.E., Hastie, K.M. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4ogx H L 0 A protein plasma kallikrein HYDROLASE/ANTIBODY 01/16/14 Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Edwards, T.E., Clifton, M.C., Abendroth, J., Nixon, A., Ladner, R. 2.4 X-RAY DIFFRACTION 0.236 0.185 False True IGHV3 IGKV1 Kappa None None None None None 4am0 C D 0 T protein envelope protein, VIRAL PROTEIN 03/06/12 Structure of Dengue virus strain 4 DIII in complex with Fab 2H12 DENGUE VIRUS; HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus dengue virus Midgley, C.M., Flanagan, A., Mongkolsapaya, J., Grimes, J.M., Screaton, G.R. 3.02 X-RAY DIFFRACTION 0.2522 0.1960 False False IGHV1 IGKV6 Kappa 4.2e-10 -12.792176733448072 ELISA TBD 5dhv H L 0 M protein protein rev IMMUNE SYSTEM 08/31/15 HIV-1 Rev NTD dimers with variable crossing angles HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C. 2.3 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 IGKV1 Kappa None None None None None 1oax NA O 0 IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with acenaphthenequinone RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.67 X-RAY DIFFRACTION 0.282 0.238 False True unknown unknown unknown None None None None None 7u8m H L 0 B protein NA hemagglutinin ha2 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 5.39 X-RAY DIFFRACTION 0.342 0.304 False True IGHV3 IGKV3 Kappa None None None None None 2r9h E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 09/12/07 Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab ESCHERICHIA COLI; MUS MUSCULUS escherichia coli Nguitragool, W., Miller, C. 3.1 X-RAY DIFFRACTION 0.280 0.261 False True IGHV4 IGKV4 Kappa None None None None None 1f6l NA L 0 IMMUNE SYSTEM 06/22/00 VARIABLE LIGHT CHAIN DIMER OF ANTI-FERRITIN ANTIBODY HOMO SAPIENS homo sapiens Nymalm, Y., Kravchuk, Z., Salminen, T., Chumanevich, A.A., Dubnovitsky, A.P., Kankare, J., Pentikainen, O., Lehtonen, J., Arosio, P., Martsev, S., Johnson, M.S. 2.8 X-RAY DIFFRACTION 0.257 0.191 False True IGKV1 Kappa None None None None None 5vf2 A a 0 IMMUNE SYSTEM 04/06/17 scFv 2D10 complexed with alpha 1,6 mannobiose, re-refinement MUS MUSCULUS mus musculus Porebski, P.J., Wlodawer, A., Dauter, Z., Minor, W., Stanfield, R., Jaskolski, M., Pozharski, E., Weichenberger, C.X., Rupp, B. 1.55 X-RAY DIFFRACTION 0.180 0.153 True True unknown unknown unknown None None None None None 6lmk N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/26/19 Cryo-EM structure of the human glucagon receptor in complex with Gs HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Qiao, A., Han, S., Tai, L., Sun, F., Zhao, Q., Wu, B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7fae h g 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 S protein of SARS-CoV-2 in complex bound with P36-5D2(state2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, L., Wang, X., Shan, S., Zhang, S. 3.65 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 6q0h H L 0 A protein hemagglutinin IMMUNE SYSTEM 08/01/19 Inferred intermediate I-7 (I-7-0) of the human antibody lineage 652 in complex with influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) McCarthy, K.R., Harrison, S.C. 2.75 X-RAY DIFFRACTION 0.269 0.241 False True IGHV4 IGLV3 Lambda None None None None None 7mlu L M 0 A protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7v0v A NA 2 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6elu K L 0 J protein serum resistance associated; vsg protein ANTITOXIN 09/29/17 Structure of Serum Resistance Associated protein from T. b. rhodesiense TRYPANOSOMA BRUCEI RHODESIENSE; MUS MUSCULUS mus musculus mus musculus trypanosoma brucei rhodesiense Zoll, S., Higgins, M.K. 2.3 X-RAY DIFFRACTION 0.220 0.191 False True IGHV7 IGKV3 Kappa None None None None None 5n4j H L 0 IMMUNE SYSTEM 02/10/17 human Fab fragment 10C3 against NHBA from Neisseria meningitidis HOMO SAPIENS homo sapiens homo sapiens Maritan, M., Malito, E. 1.503 X-RAY DIFFRACTION 0.212 0.179 False True IGHV1 IGLV2 Lambda None None None None None 1e4x H L 0 P peptide cyclic peptide IMMUNE SYSTEM 07/12/00 crossreactive binding of a circularized peptide to an anti-TGFalpha antibody Fab-fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Hahn, M., Winkler, D., Misselwitz, R., Wessner, H., Welfle, K., Zahn, G., Schneider-Mergener, J., Hoehne, W. 1.9 X-RAY DIFFRACTION 0.311 0.245 False False IGHV1 IGKV10 Kappa None None None None None 6pe8 H L 0 T protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 06/20/19 Crystal structure of CD40/ABBV-323 FAB complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Argiriadi, M.A. 2.84 X-RAY DIFFRACTION 0.265 0.205 False True IGHV3 IGKV4 Kappa None None None None None 6sf6 A B 0 D peptide NA p6 epitope of cartilage oligomeric matrix protein (comp) IMMUNE SYSTEM 08/01/19 Crystal structure of the mAb 15A in complex with COMP-epitope P6 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus Dobritzsch, D., Ge, C., Holmdahl, R. 1.9 X-RAY DIFFRACTION 0.203 0.174 False True IGHV1 IGKV1 Kappa None None None None None 5k9q H L 0 B protein NA hemagglutinin ha2 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.503 X-RAY DIFFRACTION 0.218 0.182 False True IGHV1 IGKV1 Kappa None None None None None 5ggt H L 0 A protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 06/16/16 PD-L1 in complex with BMS-936559 Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heo, Y.S. 2.8 X-RAY DIFFRACTION 0.269 0.211 False True IGHV1 IGKV3 Kappa None None None None None 4mhj H L 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 6.98 X-RAY DIFFRACTION 0.387 0.377 False True IGHV1 IGKV3 Kappa 1e-09 -12.27819680469229 BLI TBD 5njd V U 0 A | J protein | protein NA | NA interleukin-12 subunit beta | interleukin-23 subunit alpha IMMUNE SYSTEM 03/28/17 Structure of Interleukin 23 in complex with Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Bloch, Y., Savvides, S.N. 3.9 X-RAY DIFFRACTION 0.312 0.272 False True IGHV3 IGLV1 Lambda None None None None None 7e5r L H 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 2dqd H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/25/06 Crystal structure of hyhel-10 FV mutant (Hy50f) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.215 0.186 False True IGHV3 IGKV5 Kappa None None None None None 3whe 7 8 0 K protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 6p4c H L 0 IMMUNE SYSTEM 05/27/20 HyHEL10 Fab carrying four heavy chain mutations (HyHEL10-4x): L4F, Y33H, S56N, and Y58F MUS MUSCULUS mus musculus mus musculus Langley, D.B., Christ, D. 1.85 X-RAY DIFFRACTION 0.223 0.188 False True IGHV3 IGKV5 Kappa None None None None None 5thr T U 0 B protein bg505 sosip gp41 VIRAL PROTEIN 09/30/16 Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 8.9, 8.9 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 2exw E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 11/09/05 Crystal structure of a EcClC-Fab complex in the absence of bound ions ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lobet, S., Dutzler, R. 3.2 X-RAY DIFFRACTION 0.314 0.268 False False IGHV4 IGKV4 Kappa None None None None None 7wcr a b 0 A protein NA heavy chain of s5d2 fab VIRAL PROTEIN 12/20/21 RBD-1 of SARS-CoV-2 Beta spike in complex with S5D2 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 4aei I M 0 B protein alpha-mammal toxin aah2 IMMUNE SYSTEM/TOXIN 01/10/12 Crystal structure of the AaHII-Fab4C1 complex ANDROCTONUS AUSTRALIS HECTOR; MUS MUSCULUS mus musculus mus musculus androctonus australis hector Fabrichny, I.P., Mondielli, G., Conrod, S., Martin-Eauclaire, M.F., Bourne, Y., Marchot, P. 2.3 X-RAY DIFFRACTION 0.25403 0.19862 False False IGHV5 IGKV1 Kappa 8.000000000000001e-10 -12.410405717143199 Unknown TBD 5i8h G H 0 D protein bg505 sosip.664 gp41 IMMUNE SYSTEM 02/18/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Zhou, T., Kwong, P.D. 4.301 X-RAY DIFFRACTION 0.309 0.281 False True IGHV1 IGKV1 Kappa None None None None None 7cdj H L 0 E protein NA spike protein s1 VIRAL PROTEIN 06/19/20 Crystal structure of SARS-CoV-2 antibody P2C-1A3 with RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J., Wang, R. 3.396 X-RAY DIFFRACTION 0.271 0.231 False True IGHV3 IGKV1 Kappa None None None None None 6dfj H L 0 E protein dengue 1 envelope diii domain IMMUNE SYSTEM 05/14/18 Crystal structure of anti-Zika antibody Z021 bound to DENV-1 envelope protein DIII HOMO SAPIENS; DENGUE VIRUS 1 homo sapiens homo sapiens dengue virus 1 Keeffe, J.R., Bjorkman, P.J. 2.07 X-RAY DIFFRACTION 0.232 0.184 False True IGHV4 IGKV3 Kappa None None None None None 5dq9 A B 0 A carbohydrate KD2 2-(acetylamino)-6-O-[2-(acetylamino)-2-deoxy-4-O-phosphono-beta-D-glucopyranosyl]-2-deoxy-1-O-phosphono-alpha-D-glucopyranose IMMUNE SYSTEM 09/14/15 Structure of S55-3 Fab in complex with Lipid A MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.245 0.212 False False IGHV5 IGKV3 Kappa None None None None None 7lk9 M N 0 NA NA NA NA IMMUNE SYSTEM 02/01/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC + COVD21-C8 LC HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 3.4 X-RAY DIFFRACTION 0.312 0.276 False True IGHV3 IGKV3 Kappa None None None None None 6cw2 A B 0 D | C protein | protein NA | NA histone acetyltransferase gcn5 | transcriptional adapter 2 GENE REGULATION 03/29/18 Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 1 SACCHAROMYCES CEREVISIAE; HOMO SAPIENS homo sapiens homo sapiens saccharomyces cerevisiae | saccharomyces cerevisiae Sun, J., Paduch, M., Kim, S.A., Kramer, R.M., Barrios, A.F., Lu, V., Luke, J., Usatyuk, S., Kossiakoff, A.A., Tan, S. 2.67 X-RAY DIFFRACTION 0.284 0.250 False True IGHV3 IGKV1 Kappa None None None None None 7cwu N G 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7wee H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv265 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 7mjh D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6pis I M 0 A protein potassium channel subfamily k member 4 ION TRANSPORT, MEMBRANE PROTEIN 06/27/19 Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure MUS MUSCULUS; CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius mus musculus Brohawn, S.G. 2.77 X-RAY DIFFRACTION 0.286 0.248 False False IGHV3 IGKV22 Kappa None None None None None 6p62 C D 0 B protein hiv-1 env bg505 nfl td+ VIRAL PROTEIN/immune system 05/31/19 HIV Env BG505 NFL TD+ in complex with antibody E70 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6vtt H L 0 G | F | E protein | protein | protein NA | NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp120 | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Cryo-EM Structure of CAP256-VRC26.25 Fab bound to HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6w09 K O 0 G protein NA e2 glycoprotein VIRUS/IMMUNE SYSTEM 02/29/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain CHIKUNGUNYA VIRUS; HOMO SAPIENS homo sapiens homo sapiens chikungunya virus Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 6mqc A B 0 D peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 10/09/18 Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-c.01 in complex with FP (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.234 0.199 False True IGHV4 IGKV2 Kappa None None None None None 7my3 D NA 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/20/21 CryoEM structure of neutralizing nanobody Nb12 in complex with SARS-CoV2 spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Xu, K., Kwong, P.D. 2.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7e9p H L 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 03/04/21 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(state2, local refinement of the RBD and 35B5 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 1jfq H L 0 IMMUNE SYSTEM 06/21/01 "ANTIGEN-BINDING FRAGMENT OF THE MURINE ANTI-PHENYLARSONATE ANTIBODY 36-71, """"FAB 36-71""""" MUS MUSCULUS mus musculus mus musculus Parhami-Seren, B., Viswanathan, M., Strong, R.K., Margolies, M.N. 1.9 X-RAY DIFFRACTION unknown 0.196 False True IGHV1 IGKV10 Kappa None None None None None 2i9l F E 0 K protein virion membrane protein m25 IMMUNE SYSTEM/VIRAL PROTEIN 09/05/06 Structure of Fab 7D11 from a neutralizing antibody against the poxvirus L1 protein VACCINIA VIRUS; MUS MUSCULUS mus musculus mus musculus vaccinia virus Su, H.P., Golden, J.W., Gittis, A.G., Moss, B., Hooper, J.W., Garboczi, D.N. 3.1 X-RAY DIFFRACTION 0.259 0.240 False False IGHV1 IGKV8 Kappa None None None None None 5m6i NA B 0 IMMUNE SYSTEM 10/25/16 Crystal structure of non-cardiotoxic Bence-Jones light chain dimer M8 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.2 X-RAY DIFFRACTION 0.227 0.195 False False IGLV2 Lambda None None None None None 6dzr H L 0 IMMUNE SYSTEM 07/05/18 Crystal structure of h38C2 K99R mutation HOMO SAPIENS homo sapiens homo sapiens Park, H., Rader, C. 2.4 X-RAY DIFFRACTION 0.228 0.182 False True IGHV6 IGKV1 Kappa None None None None None 3cfk I G 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 6cwd B b 0 D protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/30/18 Hepatitis B core-antigen in complex with scFv e13 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS GENOTYPE D SUBTYPE ADW oryctolagus cuniculus hepatitis b virus genotype d subtype adw Eren, E., Steven, A.C., Wingfield, P.T. 3.33 X-RAY DIFFRACTION 0.282 0.242 True True unknown unknown unknown None None None None None 5gs1 R Q 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 False True IGHV3 IGKV3 Kappa None None None None None 6cmg C B 0 A protein glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 03/05/18 Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent Cross-Reactive Neutralizing Human Monoclonal Antibody m102.3 HENDRA VIRUS; HOMO SAPIENS homo sapiens homo sapiens hendra virus Xu, K., Nikolov, D. 2.7 X-RAY DIFFRACTION 0.275 0.229 False True IGHV1 IGKV3 Kappa 2.74e-08 -10.316754097318308 SPR TBD 4hk0 A B 0 IMMUNE SYSTEM 10/14/12 UCA Fab (unbound) from CH65-CH67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 2.497 X-RAY DIFFRACTION 0.258 0.206 False True IGHV1 IGLV3 Lambda None None None None None 6n4b S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/18/18 Cannabinoid Receptor 1-G Protein Complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G. 3.0 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 1g7l B A 0 C protein lysozyme c HYDROLASE INHIBITOR/HYDROLASE 11/10/00 CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92S) MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Sundberg, E.J., Urrutia, M., Braden, B.C., Isern, J., Mariuzza, R.A. 2.0 X-RAY DIFFRACTION 0.240 0.207 False True IGHV2 IGKV12 Kappa None None None None None 7ley G F 0 B protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb5 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5feh B A 0 IMMUNE SYSTEM 12/17/15 Crystal structure of PCT64_35B, a broadly neutralizing anti-HIV antibody HOMO SAPIENS homo sapiens homo sapiens Murrell, S., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.279 0.259 False True IGHV3 IGKV3 Kappa None None None None None 6n1w 5 6 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 7epu A a 0 B protein NA chromodomain-helicase-dna-binding protein 1-like MOTOR PROTEIN 04/27/21 Crystal structure of HsALC1 HOMO SAPIENS homo sapiens homo sapiens Wang, L., Chen, K.J. 3.5 X-RAY DIFFRACTION 0.316 0.268 True True unknown unknown unknown None None None None None 7mzk C D 0 B protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 96 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.25 X-RAY DIFFRACTION 0.235 0.197 False True IGHV3 IGLV1 Lambda None None None None None 7c94 E D 0 F peptide NA peptide from podoplanin IMMUNE SYSTEM 06/04/20 Crystal structure of the anti-human podoplanin antibody Fab fragment complex with glycopeptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Suzuki, K., Nakamura, S., Ogasawara, S., Naruchi, K., Shimabukuro, J., Tukahara, N., Kaneko, M.K., Kato, Y., Murata, T. 2.84 X-RAY DIFFRACTION 0.255 0.220 False False IGHV5 IGKV8 Kappa None None None None None 6hjy I NA 0 D protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.78 X-RAY DIFFRACTION 0.233 0.225 False True IGHV1 None None None None None 6w4y NA B 0 A unknown 7ZW unknown IMMUNE SYSTEM 03/11/20 Structure of full-length human lambda-6A light chain JTO in complex with hydantoin stabilizer HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Morgan, G.J., Kelly, J.W. 1.91 X-RAY DIFFRACTION 0.232 0.181 False True NA IGLV6 Lambda None None None None None 7klc H L 0 A protein NA hiv-1 clade a bg505 gp120,hiv-1 clade a bg505 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/20 Crystal structure of M4H2K1 Fab bound to HIV-1 BG505 gp120 core and to 17b Fab MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 mus musculus mus musculus human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 4.3 X-RAY DIFFRACTION 0.334 0.302 False True IGHV6 IGKV3 Kappa None None None None None 2atk A B 0 C protein voltage-gated potassium channel IMMUNE SYSTEM/ION TRANSPORT 08/25/05 Structure of a mutant KcsA K+ channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Cordero-Morales, J.F., Cuello, L.G., Zhao, Y., Jogini, V., Chakrapani, S., Roux, B., Perozo, E. 2.5 X-RAY DIFFRACTION 0.261 0.238 False True IGHV1 IGKV5 Kappa None None None None None 7mwx A B 0 C protein NA core protein precursor ee2 VIRAL PROTEIN/IMMUNE SYSTEM 05/17/21 Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 with tamarin CD81 HEPACIVIRUS C; MUS MUSCULUS; SAGUINUS OEDIPUS mus musculus mus musculus hepacivirus c Kumar, A., Hossain, R.A., Yost, S.A., Bu, W., Wang, Y., Dearborn, A.D., Grakoui, A., Cohen, J.I., Marcotrigiano, J. 3.32 X-RAY DIFFRACTION 0.283 0.239 False True IGHV14 IGKV8 Kappa None None None None None 5cez H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 07/08/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with an early putative precursor of the PGT121 family at 3.0 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wilson, I.A., Garces, F. 3.031 X-RAY DIFFRACTION 0.266 0.233 False True IGHV4 unknown unknown None None None None None 1v7n K O 0 Z protein thrombopoietin IMMUNE SYSTEM/CYTOKINE 12/18/03 Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R. 3.3 X-RAY DIFFRACTION 0.305 0.167 False True IGHV6 IGKV4 Kappa None None None None None 6z6v H NA 0 E | F protein | protein NA | NA complement c1q subcomponent subunit b | complement c1q subcomponent subunit c IMMUNE SYSTEM 05/29/20 Globular head of C1q in complex with the nanobody C1qNb75 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Laursen, N.S., Andersen, G.R. 2.19 X-RAY DIFFRACTION 0.227 0.178 False True IGHV1 NA NA None None None None None 7dc8 E D 0 F protein NA interleukin-6 receptor subunit alpha IMMUNE SYSTEM 10/23/20 Crystal structure of Switch Ab Fab and hIL6R in complex with ATP HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kadono, S., Fukami, T.A., Kawauchi, H., Torizawa, T., Mimoto, F. 2.757 X-RAY DIFFRACTION 0.278 0.207 False True IGHV3 IGLV2 Lambda None None None None None 6oz6 F NA 0 B protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to 3'-hydroxymureidomycin A LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.7 X-RAY DIFFRACTION 0.301 0.257 False True IGHV1 None None None None None 6rpj B NA 0 A protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 05/14/19 A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4 HOMO SAPIENS; CAMELUS BACTRIANUS camelus bactrianus homo sapiens Gao, H., Zhou, A., Zhang, F. 3.25 X-RAY DIFFRACTION 0.262 0.249 False True IGHV1 NA NA None None None None None 6dn0 A B 0 IMMUNE SYSTEM 06/05/18 Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D. HOMO SAPIENS homo sapiens homo sapiens Langley, D.B., Roome, B., Christ, D. 2.0 X-RAY DIFFRACTION 0.234 0.205 False True IGHV3 IGKV1 Kappa None None None None None 2hvk A B 0 C protein voltage-gated potassium channel Membrane Protein 07/28/06 crystal structure of the KcsA-Fab-TBA complex in high K+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y. 1.9 X-RAY DIFFRACTION 0.245 0.228 False False IGHV1 IGKV5 Kappa None None None None None 1igy B A 0 IMMUNOGLOBULIN 10/09/97 STRUCTURE OF IMMUNOGLOBULIN MUS MUSCULUS mus musculus mus musculus Harris, L.J., McPherson, A. 3.2 X-RAY DIFFRACTION 0.327 0.211 False False IGHV1 IGKV6 Kappa None None None None None 4oly H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07-G54R in complex with clade A/E 93TH057 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.351 X-RAY DIFFRACTION 0.244 0.201 False True unknown IGKV3 Kappa None None None None None 6ikm H h 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 4odx H B 0 X protein 4e10 epitope scaffold t117 IMMUNE SYSTEM 01/10/14 4E10 germline encoded precursor no.7 in complex with epitope scaffold T117 HOMO SAPIENS; ARTIFICIAL GENE homo sapiens homo sapiens artificial gene Finton, K.A.K. 3.1 X-RAY DIFFRACTION 0.304 0.280 False True IGHV1 IGKV3 Kappa 2.0600000000000003e-09 -11.850005304444045 SPR TBD 6iyn A NA 8 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 6d0x A B 0 C peptide nanp3 IMMUNE SYSTEM 04/11/18 Crystal structure of chimeric H.2140 / K.1210 Fab in complex with circumsporozoite protein NANP3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Imkeller, K., Wardemann, H., Julien, J.P. 1.849 X-RAY DIFFRACTION 0.209 0.179 False True IGHV3 IGKV1 Kappa None None None None None 6i8g B NA 0 A protein protein eds1l IMMUNE SYSTEM 11/20/18 Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB73 ARABIDOPSIS THALIANA; LAMA GLAMA lama glama arabidopsis thaliana Niefind, K., Voss, M., Toelzer, C. 2.344 X-RAY DIFFRACTION 0.222 0.194 False True IGHV1 None None None None None 1hcv A NA 0 IMMUNOGLOBULIN 07/13/96 LLAMA HEAVY CHAIN VARIABLE DOMAIN AGAINST ALPHA SUBUNIT OF HCG (HUMAN CHORIONIC GONADOTROPIN) LAMA GLAMA lama glama Spinelli, S., Cambillau, C., Tegoni, M. 1.85 X-RAY DIFFRACTION 0.218 0.171 False True unknown unknown unknown None None None None None 6ww2 H L 0 R protein NA frizzled-5,soluble cytochrome b562 MEMBRANE PROTEIN 05/07/20 Structure of human Frizzled5 by fiducial-assisted cryo-EM HOMO SAPIENS; SYNTHETIC CONSTRUCT; ESCHERICHIA COLI homo sapiens homo sapiens homo sapiens, escherichia coli Tsutsumi, N., Jude, K.M., Gati, C., Garcia, K.C. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6olp G I 0 D | C | B protein | protein | protein NA | NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 | envelope glycoprotein gp41 Viral Protein/IMMUNE SYSTEM 04/16/19 Full length HIV-1 Env AMC011 in complex with PGT151 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Rantalainen, K., Cottrell, C.A. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 1rzi H G 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 6a78 I M 0 B protein roundabout homolog 1 IMMUNE SYSTEM 07/02/18 Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the scFv fragment of murine monoclonal antibody B5209B HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mizohata, E., Nakayama, T., Kado, Y., Inoue, T. 2.1 X-RAY DIFFRACTION 0.285 0.239 False True IGHV5 IGKV12 Kappa None None None None None 1mnu H L 0 IMMUNE SYSTEM 04/30/99 UNLIGANDED BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS MUS MUSCULUS mus musculus mus musculus Van Den Elsen, J., Vandeputte-Rutten, L., Kroon, J., Gros, P. 2.5 X-RAY DIFFRACTION 0.270 0.231 False False IGHV1 IGKV1 Kappa None None None None None 7nvo N NA 0 E protein NA t-complex protein 1 subunit epsilon CHAPERONE 03/15/21 Human TRiC complex in open state with nanobody bound HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2omn NA B 0 Immune system 01/22/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P4(3)2(1)2 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.2 X-RAY DIFFRACTION 0.283 0.226 False False IGLV2 Lambda None None None None None 5mv4 O P 0 Q peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 2fx8 J N 0 R peptide fragment of hiv glycoprotein (gp41) IMMUNE SYSTEM 02/03/06 Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Brunel, F.M., Ferguson, S., Burton, D.R., Dawson, P.E., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.283 0.235 False True IGHV1 IGKV3 Kappa 3.02e-07 -8.89 SPR 17125793 7x6o J L 0 H | F protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/07/22 Cryo-EM structure of H1 hemagglutinin from A/Washington/05/2011 in complex with a neutralizing antibody 28-12 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Cong, Y., Liu, C.X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5cp7 F G 0 IMMUNE SYSTEM 07/21/15 Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides MUS MUSCULUS mus musculus mus musculus Wang, Z., Shen, J., Li, C., Li, Y., Wen, K., Yu, X., Zhang, X. 3.01 X-RAY DIFFRACTION 0.302 0.260 False False IGHV3 IGKV1 Kappa None None None None None 6o26 A B 0 C peptide circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 3246 Fab in complex with circumsporozoite protein NANA HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Castro, K., Murugan, R., Wardemann, H., Julien, J.P. 1.8 X-RAY DIFFRACTION 0.207 0.163 False True IGHV3 IGKV3 Kappa None None None None None 3vga C B 0 A protein adenosine receptor a2a SIGNALING PROTEIN 08/04/11 Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 3.1 A resolution HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T. 3.1 X-RAY DIFFRACTION 0.263 0.196 False False IGHV1 IGKV12 Kappa None None None None None 1mcs NA A 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 2kqm NA A 3 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7rso I K 0 D protein NA amc016 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/11/21 AMC016 SOSIP.v4.2 in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Cottrell, C.A., Ward, A.B. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6bzu G H 0 L peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Kong, L., Wilson, I.A., Law, M. 2.7 X-RAY DIFFRACTION 0.290 0.265 False True IGHV3 IGKV3 Kappa None None None None None 6pe9 E F 0 U | I protein | protein NA | NA tumor necrosis factor receptor superfamily member 5 | tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 06/20/19 Crystal Structure of CD40 complexed to FAB516 HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Argiriadi, M.A. 3.13 X-RAY DIFFRACTION 0.255 0.216 False True IGHV3 IGKV4 Kappa None None None None None 1bbj B A 0 IMMUNOGLOBULIN 04/30/92 CRYSTAL STRUCTURE OF A CHIMERIC FAB' FRAGMENT OF AN ANTIBODY BINDING TUMOUR CELLS HOMO SAPIENS homo sapiens Brady, R.L., Hubbard, R.E., Todd, R.J. 3.1 X-RAY DIFFRACTION unknown unknown False True unknown unknown unknown None None None None None 6niu I J 0 A protein envelope protein e Viral protein/IMMUNE SYSTEM 12/31/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 in complex with ZIKV E glycoprotein HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 4.303 X-RAY DIFFRACTION 0.359 0.264 False True IGHV4 IGLV1 Lambda None None None None None 7ew0 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Yuan, Y., Jia, G.W., Su, Z.M., Shao, Z.H. 3.42 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1p7k B A 0 IMMUNE SYSTEM 05/02/03 Crystal structure of an anti-ssDNA antigen-binding fragment (Fab) bound to 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES) MUS MUSCULUS mus musculus mus musculus Schuermann, J.P., Henzl, M.T., Deutscher, S.L., Tanner, J.J. 1.75 X-RAY DIFFRACTION 0.230 0.197 False True IGHV1 IGKV12 Kappa None None None None None 7pgb m n 0 l protein NA unknown MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False False IGHV3 IGKV1 Kappa None None None None None 6o3u B A 0 F Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 02/27/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with 06:0 PA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Wilson, I.A. 3.105 X-RAY DIFFRACTION 0.228 0.186 False True IGHV1 IGKV3 Kappa None None None None None 4g6a C D 0 B peptide e2 peptide IMMUNE SYSTEM 07/18/12 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Kong, L., Wilson, I.A., Law, M. 2.501 X-RAY DIFFRACTION 0.220 0.178 False True IGHV3 IGKV3 Kappa None None None None None 6mts H L 0 IMMUNE SYSTEM 10/21/18 Crystal structure of VRC43.03 Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Druz, A., Law, W.H., Peng, D., Doria-Rose, N.A., Kwong, P.D. 2.437 X-RAY DIFFRACTION 0.268 0.242 False True IGHV4 IGLV7 Lambda None None None None None 7l02 M K 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/10/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Henderson, R., Acharya, P. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 2w60 A B 0 IMMUNE SYSTEM 12/16/08 Anti citrullinated Collagen type 2 antibody acc4 MUS MUSCULUS mus musculus mus musculus Uysal, H., Bockermann, R., Nandakumar, K.S., Sehnert, B., Bajtner, E., Engstrom, A., Serre, G., Burkhardt, H., Thunnissen, M.M.G.M., Holmdahl, R. 1.5 X-RAY DIFFRACTION 0.220 0.169 False False IGHV9 IGKV1 Kappa None None None None None 3b5g NA A 0 IMMUNE SYSTEM 10/25/07 Crystal Structure of the Unstable and Highly Fibrillogenic PRO7SER Mutant of the Recombinant Variable Domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A. 1.9 X-RAY DIFFRACTION 0.210 0.164 False True IGLV6 Lambda None None None None None 7p5w I NA 0 C protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4nc1 E NA 0 A protein cell wall-binding repeat protein IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A2 Bound to A20.1 VHH and A26.8 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 2.61 X-RAY DIFFRACTION 0.252 0.202 False True IGHV1 None None None None None 7a3q H L 0 A protein NA envelope protein e VIRAL PROTEIN 08/18/20 Crystal structure of dengue 4 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10 DENGUE VIRUS 4; HOMO SAPIENS homo sapiens homo sapiens dengue virus 4 Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 2.7 X-RAY DIFFRACTION 0.239 0.216 False True IGHV1 IGLV2 Lambda None None None None None 4onf H L 0 P peptide amyloid beta a4 protein IMMUNE SYSTEM 01/28/14 Fab fragment of 3D6 in complex with amyloid beta 1-7 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Feinberg, H., Saldanha, J.W., Diep, L., Goel, A., Widom, A., Veldman, G.M., Weis, W.I., Schenk, D., Basi, G.S. 2.0 X-RAY DIFFRACTION 0.203 0.158 False True IGHV5 IGKV1 Kappa 1.2e-09 -12.170174257779676 Unknown TBD 6tcp F E 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.5 X-RAY DIFFRACTION 0.239 0.212 False True IGHV3 IGKV1 Kappa None None None None None 5u5m B A 0 C | E protein | protein NA | NA immunoglobulin g binding protein a | protein l IMMUNE SYSTEM 12/06/16 CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-MEDITOPE HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens staphylococcus aureus | finegoldia magna Williams, J.C., Bzymek, K.P., Pucket, J., Avery, K.A., Ma, Y., Xie, J., Zer, C., Horne, D. 1.88 X-RAY DIFFRACTION 0.197 0.161 False True IGHV3 IGKV1 Kappa None None None None None 3dro B A 0 P peptide elleldkwaslwn gp41 peptide IMMUNE SYSTEM 07/11/08 Crystal structure of the HIV-1 Cross Neutralizing Antibody 2F5 in complex with gp41 Peptide ELLELDKWASLWN grown in ammonium sulfate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., Pai, E.F. 3.9 X-RAY DIFFRACTION 0.263 0.222 False True IGHV2 IGKV1 Kappa None None None None None 6mhr A B 0 C protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 09/18/18 Structure of the human 4-1BB / Urelumab Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kimberlin, C.R., Chin, S.M., Roe-Zurz, Z., Xu, A., Yang, Y. 2.8 X-RAY DIFFRACTION 0.222 0.200 False True IGHV4 IGKV3 Kappa 2.2000000000000002e-08 -10.446804596890326 SPR TBD 3tnm A B 0 IMMUNE SYSTEM 09/01/11 Crystal structure of A32 Fab, an ADCC mediating anti-HIV-1 antibody HOMO SAPIENS homo sapiens homo sapiens Wu, X., Pazgier, M. 1.85 X-RAY DIFFRACTION 0.232 0.187 False True IGHV4 IGLV2 Lambda None None None None None 6qpg N NA 0 D | E protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit RNA BINDING PROTEIN 02/13/19 Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205 INFLUENZA A VIRUS (STRAIN A/NORTHERN TERRITORY/60/1968 H3N2); CAMELIDAE camelidae influenza a virus (strain a/northernterritory/60/1968 h3n2) | influenza a virus (strain a/northernterritory/60/1968 h3n2) Fan, H.T., Keown, J.R., Fodor, E., Grimes, J.M. 3.34 X-RAY DIFFRACTION 0.305 0.251 False True IGHV3 NA NA None None None None None 2i60 H L 0 G protein exterior membrane glycoprotein(gp120) VIRAL PROTEIN/IMMUNE SYSTEM 08/26/06 Crystal structure of [Phe23]M47, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 GP120 envelope glycoprotein and anti-HIV-1 antibody 17B HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.-C., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.281 0.215 False True IGHV1 IGKV3 Kappa 6.240000000000001e-09 -11.193370928227925 SPR TBD 6vep O P 0 Q protein insulin receptor subunit alpha HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM 06/03/20 Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G.T. 2.9 X-RAY DIFFRACTION 0.225 0.193 False True IGHV2 IGKV8 Kappa None None None None None 3mlu H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a ZAM18 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.77 X-RAY DIFFRACTION 0.310 0.196 False False IGHV5 IGLV3 Lambda None None None None None 5tr1 H L 0 A protein chloride channel protein TRANSPORT PROTEIN 10/25/16 Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation BOS TAURUS; MUS MUSCULUS mus musculus mus musculus bos taurus Park, E., MacKinnon, R. 3.95 ELECTRON MICROSCOPY False False IGHV3 IGKV6 Kappa None None None None None 1ken T U 0 C | E protein | protein NA | NA hemagglutinin ha1 | hemagglutinin ha1 Viral protein/Immune system 11/16/01 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) | influenza a virus (a/x-31(h3n2)) Barbey-Martin, C., Gigant, B., Bizebard, T., Calder, L.J., Wharto, S.A., Skehel, J.J., Knossow, M. 3.5 X-RAY DIFFRACTION 0.323 0.255 False False IGHV3 IGKV4 Kappa None None None None None 1u8j B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKWAG HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.239 0.229 False False IGHV2 IGKV1 Kappa None None None None None 6uum H F 0 NA NA NA NA IMMUNE SYSTEM 10/30/19 Crystal structure of antibody 438-B11 DSS mutant (Cys98A-Cys100aA) HOMO SAPIENS homo sapiens homo sapiens Kumar, S., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.269 0.229 False True unknown IGKV3 Kappa None None None None None 1tpx B C 0 A protein major prion protein UNKNOWN FUNCTION 06/16/04 Ovine recombinant PrP(114-234), ARQ variant in complex with the Fab of the VRQ14 antibody OVIS ARIES; MUS MUSCULUS mus musculus mus musculus ovis aries Eghiaian, F., Grosclaude, J., Lesceu, S., Debey, P., Doublet, B., Treguer, E., Rezaei, H., Knossow, M. 2.56 X-RAY DIFFRACTION 0.282 0.220 False False IGHV9 IGKV1 Kappa None None None None None 5dd3 H L 0 IMMUNE SYSTEM 08/24/15 Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I., Pemble IV, C.W., Haynes, B.F. 1.797 X-RAY DIFFRACTION 0.248 0.199 False True IGHV4 IGKV1 Kappa None None None None None 2mmx NA A 7 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 4f15 H I 0 G protein hemagglutinin IMMUNE SYSTEM 05/06/12 Molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Lee, J.H., Park, Y.H., Khan, T.G., Lee, J.Y., Kang, S.H., Alam, I. 2.81 X-RAY DIFFRACTION 0.289 0.233 False False IGHV3 IGKV7 Kappa None None None None None 6myy D C 0 B protein 426c ds-sosip d3 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/18 Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 3 Fabs bound, sharpened map HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Borst, A.J., Weidle, C.E., Gray, M.D., Frenz, B., Snijder, J., Joyce, M.G., Georgiev, I.S., Stewart-Jones, G.B.E., Kwong, P.D., McGuire, A.T., DiMaio, F., Stamatatos, L., Pancera, M., Veesler, D. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 5mwn N NA 0 A protein type vi secretion protein TRANSPORT PROTEIN 01/18/17 Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 LAMA GLAMA; ESCHERICHIA COLI escherichia coli Cambillau, C., Nguyen, V.S., Spinelli, S., Legrand, P. 2.2 X-RAY DIFFRACTION 0.220 0.199 False True IGHV1 None None None None None 3jbq H L 0 F protein phosphodiesterase 5/6 chimera catalytic domain HYDROLASE/IMMUNE SYSTEM 09/17/15 Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6 MUS MUSCULUS; BOS TAURUS mus musculus mus musculus bos taurus Zhang, Z., He, F., Constantine, R., Baker, M.L., Baehr, W., Schmid, M.F., Wensel, T.G., Agosto, M.A. 11 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa None None None None None 3ijh B A 0 B carbohydrate KO2 PROP-2-EN-1-YL D-GLYCERO-ALPHA-D-TALO-OCT-2-ULOPYRANOSIDONIC ACID IMMUNE SYSTEM 08/04/09 Structure of S67-27 in Complex with Ko MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.1 X-RAY DIFFRACTION 0.254 0.213 False False IGHV7 IGKV8 Kappa 9.999999999999999e-05 -5.456976357641017 Unknown TBD 1mak NA A 8 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7vsu D C 0 NA NA NA NA BIOSYNTHETIC PROTEIN 10/27/21 Crystal structure of Fab fragment of anti-mesothelin antibody HOMO SAPIENS homo sapiens homo sapiens Yang, Z., Ying, T. 3.1 X-RAY DIFFRACTION 0.249 0.215 False True IGHV4 IGKV1 Kappa None None None None None 7r8l H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 RBD in complex with neutralizing antibody C099 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 2.6 X-RAY DIFFRACTION 0.229 0.180 False True IGHV3 IGKV3 Kappa None None None None None 3cdf NA C 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 5xcu D E 0 F peptide ha peptide IMMUNE SYSTEM 03/23/17 Crystal structure of 12CA5 Fv-clasp fragment with its antigen peptide MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 2.454 X-RAY DIFFRACTION 0.247 0.199 False True IGHV5 IGKV8 Kappa None None None None None 7ocy C NA 0 A | B protein | protein NA | NA abc transporter atp-binding protein | abc transporter atp-binding protein MEMBRANE PROTEIN 04/28/21 Enterococcus faecalis EfrCD in complex with a nanobody ENTEROCOCCUS FAECALIS; VICUGNA PACOS vicugna pacos enterococcus faecalis | enterococcus faecalis Ehrenbolger, K., Hutter, C.A.J., Meier, G., Seeger, M.A., Barandun, J. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4uif K L 0 C protein dengue virus serotype 2 strain pvp94 07 - envelopeprotein 03/30/15 Cryo-EM structure of Dengue virus serotype 2 in complex with antigen- binding fragments of human antibody 2D22 DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.-N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Junior, J.E., Lok, S.-M. 6.5 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 4c2i H L 0 C protein envelope protein VIRUS 08/18/13 Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4 HOMO SAPIENS; DENGUE VIRUS 1 homo sapiens homo sapiens dengue virus 1 Fibriansah, G., Tan, J.L., de Alwis, R., Smith, S.A., Ng, T.-S., Kostyuchenko, V.A., Ibarra, K.D., Harris, E., de Silva, A., Crowe Junior, J.E., Lok, S.-M. 6.0 ELECTRON MICROSCOPY False False IGHV3 IGLV1 Lambda None None None None None 7x2f E NA 0 A | B | D protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/25/22 Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Teng, X., Zheng, S. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2c1o H L 0 IMMUNE SYSTEM 09/19/05 ENAIIHis Fab fragment in the free form MUS MUSCULUS mus musculus mus musculus Parkkinen, T., Nevanen, T., Koivula, A., Rouvinen, J. 2.75 X-RAY DIFFRACTION 0.3011 0.2184 False True IGHV1 IGKV1 Kappa None None None None None 6xxn F NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 6sc6 B NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR apo structure HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., House, D., Rittinger, K. 2.25 X-RAY DIFFRACTION 0.246 0.199 False True IGHV3 None None None None None 6wo3 H L 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/24/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody U1 RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1; HOMO SAPIENS homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 2.382 X-RAY DIFFRACTION 0.260 0.230 False True IGHV1 IGKV1 Kappa None None None None None 6my4 A B 0 IMMUNE SYSTEM 11/01/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M,LC-S30bR] HOMO SAPIENS homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M. 1.69 X-RAY DIFFRACTION 0.230 0.189 False True IGHV3 IGKV1 Kappa None None None None None 1yef H L 0 L Hapten PNC PARA-NITROBENZYL GLUTARYL GLYCINIC ACID CATALYTIC ANTIBODY 05/29/97 STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH SUBSTRATE ANALOGUE MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Knossow, M. 2.0 X-RAY DIFFRACTION 0.248 0.199 False False IGHV1 IGKV1 Kappa None None None None None 2znx B b 0 Z protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 05/02/08 5-Fluorotryptophan Incorporated ScFv10 Complexed to Hen Egg Lysozyme MUS MUSCULUS; SYNTHETIC CONSTRUCT; GALLUS GALLUS mus musculus, synthetic construct gallus gallus DeSantis, M.E., Acchione, M., Li, M., Walter, R.L., Wlodawer, A., Smith-Gill, S. 2.3 X-RAY DIFFRACTION 0.232 0.193 True True unknown unknown unknown None None None None None 5gs1 I i 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 7v0v A NA 0 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7oan F NA 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN 04/19/21 Nanobody C5 bound to Spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Naismith, J.H., Weckener, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3cfk N M 0 M Hapten B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 7qnb N NA 0 E | D protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2p44 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE5A-mono-1 crystal form with five se-met sites (M34, M51, F68M, M83, L86M) in vhh scaffold CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 1.8 X-RAY DIFFRACTION 0.238 0.193 False True IGHV1 2.00e-08 -10.67 Other 30 18445622 7nd6 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-40 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 7.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7mmo A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 04/30/21 LY-CoV1404 neutralizing antibody against SARS-CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hendle, J., Pustilnik, A., Sauder, J.M., Coleman, K.A., Boyles, J.S., Dickinson, C.D. 2.427 X-RAY DIFFRACTION 0.253 0.226 False True IGHV2 IGLV2 Lambda None None None None None 1g9e A NA 13 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7tpr D NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/22 Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Butay, K.J., Zhu, J., Dandey, V.P., Hong, J., Kwon, H.J., Chen, C.Z., Duan, Z., Li, D., Ren, H., Liang, T., Martin, N., Esposito, D., Ortega-Rodriguez, U., Xu, M., Xie, H., Ho, M., Cachau, R., Borgnia, M.J. 2.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4krm B NA 0 A protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.655 X-RAY DIFFRACTION 0.244 0.208 False True IGHV1 None None None None None 6cdp A B 0 C peptide hiv-1 fusion peptide 512-519 IMMUNE SYSTEM 02/08/18 Vaccine-elicited HIV-1 neutralizing antibody vFP20.01 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.456 X-RAY DIFFRACTION 0.264 0.212 False True IGHV1 IGKV1 Kappa 1.64e-09 -11.985097354847062 Unknown TBD 4ocy H L 0 IMMUNE SYSTEM 01/09/14 Fab for methotrexate (unbound apo) MUS MUSCULUS mus musculus mus musculus Longenecker, K.L., Judge, R.A., Gayda, S., Manoj, S., Saldana, S., Ruan, Q., Swift, K., Tetin, S. 2.79 X-RAY DIFFRACTION 0.206 0.182 False True IGHV3 IGKV1 Kappa None None None None None 6wfy H L 0 P peptide NA npna4 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab224 in complex with NPNA4 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 1.226 X-RAY DIFFRACTION 0.183 0.169 False True IGHV3 IGLV1 Lambda None None None None None 3fo9 H L 0 H Hapten DIK 5-{[4-(5-METHYL-3-OXOHEX-4-EN-1-YL)PHENYL]AMINO}-5-OXOPENTANOIC ACID IMMUNE SYSTEM 12/29/08 Crystal structure of aldolase antibody 33F12 Fab' in complex with hapten 1,3-diketone MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.249 0.215 False True IGHV6 IGKV1 Kappa None None None None None 1mlc B A 0 E protein hen egg white lysozyme COMPLEX (ANTIBODY/ANTIGEN) 03/10/95 MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG-WHITE LYSOZYME COMPLEXED WITH LYSOZYME MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Braden, B.C., Souchon, H., Eisele, J.-L., Bentley, G.A., Bhat, T.N., Navaza, J., Poljak, R.J. 2.5 X-RAY DIFFRACTION 0.282 unknown False True IGHV1 IGKV5 Kappa 9.10e-08 -9.6 SPR 25 10229844 5tp3 A NA 0 IMMUNE SYSTEM 10/19/16 Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4 LAMA GLAMA lama glama Wrapp, D., Gilman, M.S.A., McLellan, J.S. 1.874 X-RAY DIFFRACTION 0.208 0.170 False True IGHV1 None None None None None 6ada C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148D mutant CLC-ec1 in 200mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 3.153 X-RAY DIFFRACTION 0.290 0.231 False False IGHV4 IGKV4 Kappa None None None None None 6yz7 D NA 0 A protein spike glycoprotein VIRAL PROTEIN 05/06/20 H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Naismith, J.H., Ren, J., Zhou, D., Zhao, Y., Stuart, D.I. 3.3 X-RAY DIFFRACTION 0.269 0.238 False True IGHV1 None None None None None 6mhg H L 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7te8 D NA 0 D Hapten P0T cannabidiol BIOSYNTHETIC PROTEIN 01/04/22 CA14-CBD-DB21 ternary complex ARTIFICIAL SEQUENCES artificial sequences artificial sequences Cao, S., Zheng, N. 1.998 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 NA NA None None None None None 1cic D C 0 IMMUNOGLOBULIN 03/31/99 IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225 MUS MUSCULUS mus musculus mus musculus Bentley, G.A. 2.5 X-RAY DIFFRACTION unknown 0.179 False False IGHV2 IGKV12 Kappa None None None None None 6o3b G E 0 H protein frizzled-7 SIGNALING PROTEIN 02/26/19 Crystal structure of Frizzled 7 CRD in complex with F6 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Raman, S., Beilschmidt, M., Fransson, J., Julien, J.P. 2.5 X-RAY DIFFRACTION 0.283 0.248 False True IGHV3 IGKV1 Kappa None None None None None 4rir A B 0 IMMUNE SYSTEM 10/07/14 Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk HOMO SAPIENS homo sapiens homo sapiens Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H.-X., Alam, S.M., Hwang, K.-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F. 2.5 X-RAY DIFFRACTION 0.289 0.220 False True IGHV5 IGLV6 Lambda None None None None None 5tqq H L 0 A protein chloride channel protein TRANSPORT PROTEIN 10/24/16 Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation MUS MUSCULUS; BOS TAURUS mus musculus mus musculus bos taurus Park, E., MacKinnon, R. 3.76 ELECTRON MICROSCOPY False True IGHV3 IGKV6 Kappa None None None None None 7cw3 o p 0 N | M protein | protein NA | NA fab light chain | fab heavy chain VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG (subregion around icosahedral 2-fold vertex) CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 9.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 6vmk l k 0 m protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False False IGHV1 IGKV1 Kappa None None None None None 5gis H L 0 C peptide thr-lys-pro-ile-thr-ile-gly-ser-his-ala-his-gly-asp-gln-tyr-lys IMMUNE SYSTEM 06/24/16 Crystal structure of a Fab fragment with its ligand peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Kitago, Y., Kaneko, K.K., Ogasawara, S., Kato, Y., Takagi, J. 1.93 X-RAY DIFFRACTION 0.216 0.186 False True IGHV1 IGKV5 Kappa None None None None None 6zpl F NA 0 A protein NA sodium- and chloride-dependent glycine transporter 1 MEMBRANE PROTEIN 07/08/20 Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor, sybody Sb_GlyT1#7 and bound Na and Cl ions. HOMO SAPIENS; HUNGATEICLOSTRIDIUM THERMOCELLUM (STRAIN ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372); UNIDENTIFIED unidentified homo sapiens Shahsavar, A., Stohler, P., Bourenkov, G., Zimmermann, I., Siegrist, M., Guba, W., Pinard, E., Sinning, S., Seeger, M.A., Schneider, T.R., Dawson, R.J.P., Nissen, P. 3.945 X-RAY DIFFRACTION 0.291 0.277 False True IGHV1 NA NA None None None None None 7ew4 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Zhao, C., Wang, W., Wang, H.L., Shao, Z.H. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6p9h H L 0 A protein iron-regulated heme-iron binding protein IMMUNE SYSTEM 06/17/20 Crystal structure of human anti staphylococcus aureus antibody STAU-281 Fab in complex with IsdB NEAT2 domain STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus Dong, J., Crowe, J.E. 3.003 X-RAY DIFFRACTION 0.225 0.206 False True IGHV1 IGKV3 Kappa None None None None None 1ngw H L 0 H Hapten MMP N-METHYLMESOPORPHYRIN IMMUNE SYSTEM 12/18/02 Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Yin, J., Andryski, S.E., Beuscher IV, A.E., Stevens, R.C., Schultz, P.G. 2.6 X-RAY DIFFRACTION 0.318 0.275 False True IGHV1 IGKV6 Kappa 2.07e-08 -10.48 SPR 12552112 1b0w NA C 0 IMMUNE SYSTEM 11/13/98 Structural comparison of amyloidogenic light chain dimer in two crystal forms with nonamyloidogenic counterparts HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 1.8 X-RAY DIFFRACTION 0.299 0.226 False True IGKV1 Kappa None None None None None 3wfh A B 0 B Hapten P2E (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid IMMUNE SYSTEM 07/19/13 Crystal structure of anti-Prostaglandin E2 Fab fragment PGE2 complex MUS MUSCULUS mus musculus mus musculus mus musculus Sugahara, M., Ago, H., Saino, H., Miyano, M. 1.9 X-RAY DIFFRACTION 0.200 0.168 False False IGHV1 IGKV1 Kappa None None None None None 3u9u A B 0 F protein receptor tyrosine-protein kinase erbb-4 Transferase 10/19/11 Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Hollmen, M., Liu, P., Wildiers, H., Reinvall, I., Vandorpe, T., Smeets, A., Deraedt, K., Vahlberg, T., Joensuu, H., Leahy, D.J., Schoffski, P., Elenius, K. 3.42 X-RAY DIFFRACTION 0.272 0.234 False True IGHV8 IGKV1 Kappa None None None None None 5ty6 H L 0 NA NA NA NA IMMUNE SYSTEM 11/18/16 Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 13-1b02 Fab. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Andrews, S.F., Mascola, J.R., McDermott, A.B., Kwong, P.D. 1.361 X-RAY DIFFRACTION 0.173 0.159 False True IGHV3 IGKV1 Kappa None None None None None 5az2 H L 0 IMMUNE SYSTEM 09/16/15 Crystal structure of the Fab fragment of 9E5, a murine monoclonal antibody specific for human epiregulin MUS MUSCULUS mus musculus mus musculus Kado, Y., Mizohata, E., Nagatoishi, S., Iijima, M., Shinoda, K., Miyafusa, T., Nakayama, T., Yoshizumi, T., Sugiyama, A., Kawamura, T., Lee, Y.H., Matsumura, H., Doi, H., Fujitani, H., Kodama, T., Shibasaki, Y., Tsumoto, K., Inoue, T. 1.603 X-RAY DIFFRACTION 0.238 0.193 False False IGHV14 IGKV19 Kappa None None None None None 4u0r B C 0 A protein reticulocyte binding protein 5 IMMUNE SYSTEM 07/14/14 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody 9AD4 PLASMODIUM FALCIPARUM; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus plasmodium falciparum Wright, K.E., Hjerrild, K.A., Bartlett, J., Douglas, A.D., Jin, J., Brown, R.E., Ashfield, R., Clemmensen, S.B., de Jongh, W.A., Draper, S.J., Higgins, M.K. 2.3 X-RAY DIFFRACTION 0.258 0.221 False True IGHV5 IGKV3 Kappa None None None None None 2adf H L 0 A protein von willebrand factor BLOOD CLOTTING/IMMUNE SYSTEM 07/20/05 Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Staelens, S., Hadders, M.A., Vauterin, S., Platteau, C., Vanhoorelbeke, K., Huizinga, E.G., Deckmyn, H. 1.9 X-RAY DIFFRACTION 0.220 0.191 False False IGHV9 IGKV19 Kappa None None None None None 6db8 H L 0 R nucleic-acid rna (60-mer) RNA/IMMUNE SYSTEM 05/02/18 Structural basis for promiscuous binding and activation of fluorogenic dyes by DIR2s RNA aptamer SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct synthetic construct synthetic construct Shao, Y., Shelke, S.A., Laski, A., Piccirilli, J.A. 1.86541 X-RAY DIFFRACTION 0.233 0.219 False True IGHV3 IGKV1 Kappa None None None None None 7rlx A B 0 P peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRADGQPAGDRAAGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 1.97 X-RAY DIFFRACTION 0.235 0.186 False True IGHV1 IGKV1 Kappa None None None None None 1bfv H L 0 H Hapten STG ESTRIOL 3-(B-D-GLUCURONIDE) IMMUNOGLOBULIN 05/27/97 MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI MUS MUSCULUS mus musculus mus musculus mus musculus Trinh, C.H., Phillips, S.E.V. 2.1 X-RAY DIFFRACTION 0.271 0.187 False True IGHV5 IGKV1 Kappa None None None None None 6gwp C NA 0 A protein plasminogen activator inhibitor-1 HYDROLASE 06/25/18 Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 2.28 X-RAY DIFFRACTION 0.225 0.203 False True IGHV1 None None None None None 5iwl A a 0 D protein leukocyte surface antigen cd47 CELL ADHESION 03/22/16 CD47-diabody complex HOMO SAPIENS homo sapiens homo sapiens Di, W., Jude, K.M., Garcia, K.C. 2.8 X-RAY DIFFRACTION 0.267 0.221 True True unknown unknown unknown None None None None None 6pec H L 0 A peptide NA hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 06/20/19 Vaccine-elicited NHP FP-targeting antibody DF2F-e.01 in complex with HIV fusion peptide (residue 512-519) MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 1.746 X-RAY DIFFRACTION 0.215 0.194 False True IGHV4 IGKV1 Kappa None None None None None 6u51 C NA 0 B protein nucleoprotein IMMUNE SYSTEM 08/26/19 Anti-Sudan ebolavirus Nucleoprotein Single Domain Antibody Sudan B (SB) Complexed with Sudan ebolavirus Nucleoprotein C-terminal Domain 610-738 LAMA GLAMA; SUDAN EBOLAVIRUS (STRAIN BONIFACE-76) lama glama sudan ebolavirus (strain boniface-76) Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 2.52 X-RAY DIFFRACTION 0.250 0.208 False True unknown unknown unknown None None None None None 6apd J L 0 C protein fusion glycoprotein f0,envelope glycoprotein IMMUNE SYSTEM 08/17/17 Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 RESPIRATORY SYNCYTIAL VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus, humanimmunodeficiency virus 1 Wrapp, D., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.256 0.204 False True IGHV3 IGLV1 Lambda None None None None None 6lfo S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/03/19 Cryo-EM structure of a class A GPCR monomer HOMO SAPIENS homo sapiens homo sapiens | homo sapiens | homo sapiens Liu, Z.J., Hua, T., Liu, K.W., Wu, L.J. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7q6c K NA 0 NA NA NA NA IMMUNE SYSTEM 11/06/21 complement C6 FIM1-2 bound to CP010 antibody HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA lama glama Olesen, H.G., Andersen, G.R. 2.29274 X-RAY DIFFRACTION 0.233 0.208 False True IGHV1 NA NA None None None None None 2ny1 D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (I109C, T257S, S334A, S375W, Q428C) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X, Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.250 0.209 False True IGHV1 IGKV3 Kappa 2.02e-07 SPR 17301785 1maj NA A 9 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5i17 H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1-69/IGKV3-20 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 3.3 X-RAY DIFFRACTION 0.247 0.202 False True IGHV1 IGKV3 Kappa None None None None None 5ujz H h 0 C protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 1 HOMO SAPIENS; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 3ri5 I O 0 D protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.4 X-RAY DIFFRACTION 0.248 0.232 False True IGHV1 IGLV1 Lambda None None None None None 5imm B NA 0 A protein protein vsig4 IMMUNE SYSTEM 03/06/16 Nanobody targeting mouse Vsig4 in Spacegroup P212121 MUS MUSCULUS; CAMELIDAE camelidae mus musculus Wen, Y., Zheng, F. 1.2 X-RAY DIFFRACTION 0.176 0.156 False True IGHV1 3.5000000000000003e-09 -11.535955190950428 ITC TBD 1kno D C 0 D Hapten PNP METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER CATALYTIC ANTIBODY 09/11/95 CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES MUS MUSCULUS mus musculus mus musculus mus musculus Charbonnier, J.-B., Gigant, B., Knossow, M. 3.2 X-RAY DIFFRACTION 0.272 0.200 False False IGHV5 IGKV9 Kappa None None None None None 3t0x NA A 0 A Hapten DIW 1-(3-SULFOPROPYL)-4-[(1E,3E)-3-(1,3,3-TRIMETHYL-1,3-DIHYDRO-2H-INDOL-2-YLIDENE)PROP-1-EN-1-YL]QUINOLINIUM DYE-BINDING PROTEIN 07/20/11 Fluorogen Activating Protein M8VLA4(S55P) in complex with dimethylindole red HOMO SAPIENS homo sapiens homo sapiens Stanfield, R., Senutovitch, N., Bhattacharyya, S., Rule, G., Wilson, I.A., Armitage, B., Waggoner, A.S., Berget, P. 1.96 X-RAY DIFFRACTION 0.242 0.209 False True IGLV1 Lambda 1e-08 -10.913952715282035 Unknown TBD 5mp1 F G 0 E peptide microtubule-associated protein tau IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 3.1 X-RAY DIFFRACTION 0.268 0.222 False False IGHV1 IGKV8 Kappa None None None None None 6qkd I NA 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGHV1 None None None None None 4wht A B 0 a peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 2kh2 B b 20 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 4i0c D NA 0 A protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 11/16/12 The structure of the camelid antibody cAbHuL5 in complex with human lysozyme HOMO SAPIENS; CAMELUS DROMEDARIUS camelus dromedarius homo sapiens De Genst, E., Chan, P.H., Pardon, E., Kumita, J.R., Christodoulou, J., Menzer, L., Chirgadze, D.Y., Robinson, C.V., Muyldermans, S., Matagne, A., Wyns, L., Dobson, C.M., Dumoulin, M. 1.95 X-RAY DIFFRACTION 0.219 0.187 False True IGHV1 NA NA None None None None None 5xli d b 0 IMMUNE SYSTEM 05/10/17 Structure of anti-Angiotensin II type2 receptor antibody (D5711-4A03) MUS MUSCULUS mus musculus mus musculus Asada, H., Horita, S., Iwata, S., Hirata, K. 1.696 X-RAY DIFFRACTION 0.216 0.180 False False IGHV5 IGKV4 Kappa None None None None None 7ora H L 0 C protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the T478K mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-45 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.6 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 IGKV3 Kappa None None None None None 7uaq H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/13/22 Structure of the SARS-CoV-2 NTD in complex with C1520, local refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 4k07 NA D 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 7tb8 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/21 Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6mph Q R 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 1u8n B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKFAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.56 X-RAY DIFFRACTION 0.230 0.205 False False IGHV2 IGKV1 Kappa None None None None None 4yk4 C B 0 A protein hemagglutinin Viral protein/Immune system 03/03/15 Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Schmidt, A.G., Harrison, S.C. 2.8 X-RAY DIFFRACTION 0.260 0.220 False True IGHV4 IGKV1 Kappa 3.64e-07 -8.78422937966864 BLI TBD 5yy5 H L 0 A protein mers-cov rbd VIRAL PROTEIN 12/08/17 Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Zhang, S.Y., Wang, P.F., Zhou, P.P., Wang, X.Q., Zhang, L.Q. 2.8 X-RAY DIFFRACTION 0.279 0.246 False True IGHV3 IGLV1 Lambda None None None None None 7n9e D NA 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/17/21 Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB34 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Sun, D., Zhang, C., Shi, Y. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ws0 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6i8s G K 0 C protein plasminogen activator inhibitor 1 BLOOD CLOTTING 11/21/18 Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens Vousden, K.A., Lundqvist, T., Popovic, B. 2.9 X-RAY DIFFRACTION 0.243 0.219 False True IGHV1 IGKV1 Kappa None None None None None 1maj NA A 2 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5vl2 E NA 0 E Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 4i2x D C 0 F protein signal-regulatory protein gamma IMMUNE SYSTEM 11/23/12 Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nettleship, J.E., Ren, J., Stuart, D.I., Owens, R.J., Oxford Protein Production Facility (OPPF) 2.48 X-RAY DIFFRACTION 0.260 0.196 False False IGHV1 IGKV6 Kappa 1.2e-06 -8.077441989548914 AUC TBD 4z9k B NA 0 A protein ricin Hydrolase/Immune system 04/10/15 Ricin A chain bound to camelid nanobody (VHH2)(F5) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.5 X-RAY DIFFRACTION 0.195 0.178 False True IGHV1 2.2000000000000003e-09 -11.81104868630058 SPR TBD 4s1s H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 01/14/15 Crystal structure of a VRC01-lineage antibody, 45-VRC01.H5.F-185917, in complex with clade A/E HIV-1 gp120 core HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D. 3.39 X-RAY DIFFRACTION 0.300 0.262 False True unknown IGKV3 Kappa None None None None None 7v0v A NA 8 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6e8v A B 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False True IGHV1 IGLV1 Lambda None None None None None 4kk5 E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the CLC-ec1 deltaNC construct in 20mM fluoride and 20mM bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.171 X-RAY DIFFRACTION 0.271 0.232 False True IGHV4 IGKV4 Kappa None None None None None 7lbe H G 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 01/07/21 CryoEM structure of the HCMV Trimer gHgLgO in complex with neutralizing fabs 13H11 and MSL-109 HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN); HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus (strain merlin) Kschonsak, M., Rouge, L., Arthur, C.P., Hoangdung, H., Patel, N., Kim, I., Johnson, M., Kraft, E., Rohou, A.L., Gill, A., Martinez-Martin, N., Payandeh, J., Ciferri, C. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7qne G NA 0 A | E protein | protein NA | NA gaba(a) receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4uil H L 0 H Hapten QI9 Quinine 03/30/15 crystal structure of quinine-dependent Fab 314.1 with quinine MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. 2.853 X-RAY DIFFRACTION 0.3352 0.2685 False False IGHV1 IGKV10 Kappa 5.8e-08 -9.872450587373468 Unknown TBD 7ks9 H L 0 B protein NA spike glycoprotein Viral Protein/IMMUNE SYSTEM 11/21/20 Cryo-EM structure of prefusion SARS-CoV-2 spike glycoprotein in complex with 910-30 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 4.75 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4xce H L 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylcholine (06:0 PC); C2 space group HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.93 X-RAY DIFFRACTION 0.247 0.192 False True IGHV1 IGKV3 Kappa None None None None None 2ap2 D C 0 Q peptide protein (p-glycoprotein) IMMUNE SYSTEM 03/22/99 SINGLE CHAIN FV OF C219 IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Van Den Elsen, J.M.H., Rose, D.R. 2.4 X-RAY DIFFRACTION 0.274 0.221 True True IGHV14 IGKV8 Kappa None None None None None 7a4d I NA 0 L peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 4r9y N M 0 A | C protein | protein NA | NA platelet factor 4 | platelet factor 4 IMMUNE SYSTEM/Cytokine 09/08/14 Crystal structure of KKOFab in complex with platelet factor 4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 4.11 X-RAY DIFFRACTION 0.382 0.317 False True IGHV1 IGKV6 Kappa None None None None None 5i1d B A 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV4-1 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.0 X-RAY DIFFRACTION 0.251 0.216 False True IGHV3 IGKV4 Kappa None None None None None 4fz8 H L 0 H carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 07/06/12 Crystal structure of C11 Fab, an ADCC mediating anti-HIV-1 antibody. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, X., Tolbert, W.D., Pazgier, M. 2.66 X-RAY DIFFRACTION 0.313 0.253 False True IGHV3 IGKV2 Kappa None None None None None 6xsw A B 0 C protein NA neurogenic locus notch homolog protein 3 SIGNALING PROTEIN/Immune System 07/16/20 Structure of the Notch3 NRR in complex with an antibody Fab Fragment RATTUS NORVEGICUS; HOMO SAPIENS rattus norvegicus rattus norvegicus homo sapiens Bard, J. 2.98 X-RAY DIFFRACTION 0.256 0.233 False True IGHV3 IGKV1 Kappa None None None None None 4kml B NA 0 A protein major prion protein MEMBRANE PROTEIN/PROTEIN BINDING 05/08/13 Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Abskharon, R.N.N, Giachin, G., Wohlkonig, A., Soror, S.H., Pardon, E., Legname, G., Steyaert, J. 1.5 X-RAY DIFFRACTION 0.192 0.175 False True IGHV3 None None None None None 7m6h E G 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, BG7-20 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7a29 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/16/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) 2-up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6z3k H L 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 5esv H L 0 G protein 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase,envelope glycoprotein gp160 IMMUNE SYSTEM 11/17/15 Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade C Superinfecting Strain of Donor CAP256. HOMO SAPIENS; HAEMOPHILUS INFLUENZAE homo sapiens homo sapiens haemophilus influenzae, human immunodeficiencyvirus 1, haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd) Gorman, J., Yang, M., Kwong, P.D. 3.105 X-RAY DIFFRACTION 0.259 0.209 False True IGHV3 IGKV3 Kappa None None None None None 3l5w B A 0 J protein interleukin-13 IMMUNE SYSTEM 12/22/09 Crystal structure of the complex between IL-13 and C836 FAB MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.253 0.205 False True IGHV8 IGKV16 Kappa 5.40e-11 -14 SPR 25 20226193 2hg5 A B 0 C protein kcsa channel MEMBRANE PROTEIN 06/26/06 Cs+ complex of a K channel with an amide to ester substitution in the selectivity filter MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Valiyaveetil, F.I., MacKinnon, R., Muir, T.W. 2.75 X-RAY DIFFRACTION 0.271 0.239 False False IGHV1 IGKV5 Kappa None None None None None 3dv4 B A 0 B carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/18/08 Crystal structure of SAG506-01, tetragonal, crystal 1 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.336 0.269 False True IGHV7 IGKV8 Kappa None None None None None 6pds B A 0 C peptide NA hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 06/19/19 Vaccine-elicited NHP FP-targeting antibody 0PV-a.04 in complex with HIV fusion peptide (residue 512-519) MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 1.893 X-RAY DIFFRACTION 0.220 0.193 False True IGHV4 IGKV1 Kappa None None None None None 6qtl F NA 0 E Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 5ywy H L 0 A protein prostaglandin e2 receptor ep4 subtype,prostaglandin e2receptor ep4 subtype SIGNALING PROTEIN-IMMUNE SYSTEM 11/30/17 Crystal structure of the clinically important GPCR in complex with functional antibody. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T. 3.2 X-RAY DIFFRACTION 0.252 0.222 False True IGHV1 IGKV14 Kappa 5.9000000000000006e-08 -9.862322414589235 Unknown TBD 5w08 I J 0 B protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 05/30/17 A/Texas/50/2012(H3N2) Influenza hemagglutinin in complex with K03.12 Fab INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 2.6 X-RAY DIFFRACTION 0.262 0.240 False True IGHV1 IGLV2 Lambda 4e-08 -10.092595930642474 SPR TBD 5viy O P 0 C | E protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 6.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7mlv L M 0 A protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 6e9q E F 0 IMMUNE SYSTEM 05/01/19 The crystal structure of bovine ultralong antibody BOV-6 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.4 X-RAY DIFFRACTION 0.311 0.254 False True IGHV1 IGLV1 Lambda None None None None None 5vz1 B A 0 IMMUNE SYSTEM 05/26/17 Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains) HOMO SAPIENS homo sapiens homo sapiens Radwanska, M.J., Derewenda, U., Kossiakoff, A., Derewenda, Z.S. 2.112 X-RAY DIFFRACTION 0.268 0.218 False True IGHV3 IGKV1 Kappa None None None None None 6cr1 H L 0 IMMUNE SYSTEM 03/16/18 adalimumab EFab HOMO SAPIENS homo sapiens homo sapiens Arndt, J.W. 1.521 X-RAY DIFFRACTION 0.179 0.153 False True IGHV3 IGKV1 Kappa None None None None None 4lou C D 0 A protein h(+)/cl(-) exchange transporter clca membrane protein, tranport protein 07/13/13 Structure of the E148Q mutant of CLC-ec1 deltaNC construct in the absence of halide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.981 X-RAY DIFFRACTION 0.253 0.210 False True IGHV4 IGKV4 Kappa None None None None None 5h30 K L 0 B protein structural protein e VIRUS/IMMUNE SYSTEM 10/19/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lok, S.-M. 4.4 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7p2d C NA 0 A protein NA isoform 2 of integrin alpha-m IMMUNE SYSTEM 07/05/21 Structure of alphaMbeta2/Cd11bCD18 headpiece in complex with a nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Jensen, R.K., Andersen, G.R. 3.2 X-RAY DIFFRACTION 0.295 0.261 False True IGHV1 NA NA None None None None None 3dwt C NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 2ht3 C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/25/06 Structure of the Escherichia coli ClC chloride channel Y445L mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.3 X-RAY DIFFRACTION 0.269 0.253 False False IGHV4 IGKV4 Kappa None None None None None 7cws N K 0 O protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike Proteins Trimer in Complex with FC05 and H014 Fabs Cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L., Wang, X. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5aaw D d 0 E protein dengue serotype 4 envelope protein domain 3 07/30/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency DENGUE VIRUS; MUS MUSCULUS mus musculus dengue virus Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R. 3.27 X-RAY DIFFRACTION 0.26258 0.22661 True True unknown unknown unknown 4.320000000000001e-09 -11.411241859183763 SPR TBD 6cxg H L 0 A peptide 10v1s glycopeptide IMMUNE SYSTEM 04/03/18 anti-HIV-1 Fab 2G12 in complex with glycopeptide 10V1S HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Stanfield, R.L., Wilson, I.A. 2.298 X-RAY DIFFRACTION 0.237 0.197 False True unknown IGKV1 Kappa None None None None None 6x98 F E 0 C protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11B fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 2ipu G K 0 P peptide abeta 1-8 peptide IMMUNE SYSTEM 10/12/06 PFA1 Fab fragment complexed with Abeta 1-8 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Gardberg, A.S., Dealwis, C. 1.65 X-RAY DIFFRACTION 0.225 0.182 False False IGHV8 IGKV1 Kappa None None None None None 2kh2 B b 13 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5vjq A B 0 I protein lysozyme HYDROLASE/IMMUNE SYSTEM 04/19/17 Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I) MUS MUSCULUS; ANAS PLATYRHYNCHOS mus musculus mus musculus anas platyrhynchos Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.235 0.193 False True IGHV3 IGKV5 Kappa None None None None None 5c2u B NA 0 A protein nup54 TRANSPORT PROTEIN 06/16/15 Ferredoxin-like domain of nucleoporin Nup54 bound to a nanobody CAMELUS DROMEDARIUS; XENOPUS LAEVIS camelus dromedarius xenopus laevis Chug, H., Trakhanov, S., Hulsmann, B.B., Pleiner, T., Gorlich, D. 1.55 X-RAY DIFFRACTION 0.205 0.176 False True IGHV1 None None None None None 6idi M N 0 F protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 8.0. DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 12 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7s3m H L 0 A peptide NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/07/21 MERS-CoV S stem helix peptide bound to Fab22 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Goldsmith, J.A., McLellan, J.S. 2.4 X-RAY DIFFRACTION 0.252 0.209 False True IGHV1 IGKV1 Kappa None None None None None 7nxa H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the receptor binding domain of SARS-CoV-2 B.1.351 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.5 X-RAY DIFFRACTION 0.253 0.205 False True IGHV3 IGKV1 Kappa None None None None None 3t2n H L 0 A protein serine protease hepsin HYDROLASE 07/22/11 Human hepsin protease in complex with the Fab fragment of an inhibitory antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Koschubs, T., Dengl, S., Duerr, H., Kaluza, K., Georges, G., Hartl, C., Jennewein, S., Lanzendoerfer, M., Auer, J., Stern, A., Huang, K.-S., Kostrewa, D., Ries, S., Hansen, S., Kohnert, U., Cramer, P., Mundigl, O. 2.55 X-RAY DIFFRACTION 0.275 0.242 False True IGHV7 IGLV7 Lambda 3.98e-08 -10.5 SPR 37 22132769 1j05 H L 0 Immune system 11/01/02 The crystal structure of anti-carcinoembryonic antigen monoclonal antibody T84.66 Fv fragment MUS MUSCULUS mus musculus mus musculus Kondo, H., Nishimura, Y., Shiroishi, M., Asano, R., Noro, N., Tsumoto, K., Kumagai, I. 1.5 X-RAY DIFFRACTION unknown unknown False True IGHV14 IGKV3 Kappa None None None None None 7f63 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/24/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody chAb-45 (Focused refinement of S-RBD and chAb-45 region) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 3g6a H L 0 IMMUNE SYSTEM 02/06/09 Crystal structure of anti-IL-13 antibody CNTO607 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.1 X-RAY DIFFRACTION 0.283 0.208 False True IGHV3 IGLV3 Lambda None None None None None 5nuz H L 0 D protein pre-glycoprotein polyprotein gp complex IMMUNE SYSTEM 05/03/17 Junin virus GP1 glycoprotein in complex with an antibody Fab fragment MUS MUSCULUS; JUNIN MAMMARENAVIRUS mus musculus mus musculus junin mammarenavirus Zeltina, A., Krumm, S.A., Sahin, M., Struwe, W.B., Harlos, K., Nunberg, J.H., Crispin, M., Pinschewer, D.D., Doores, K.J., Bowden, T.A. 1.85 X-RAY DIFFRACTION 0.210 0.185 False True IGHV1 IGKV3 Kappa None None None None None 6oe4 E F 0 D protein fusion glycoprotein f0 Viral protein/immune system 03/27/19 Prefusion RSV F monomer bound by neutralizing antibody CR9501 HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2) McLellan, J.S., Gilman, M.S.A. 3.3 X-RAY DIFFRACTION 0.259 0.212 False True IGHV4 IGKV1 Kappa None None None None None 6k5i E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/29/19 Crystal structure of the E148D/R147A/F317A mutant CLC-ec1 in the presence of 20 mM NaBr ESCHERICHIA COLI MS 117-3; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 117-3 Park, K., Lim, H.H. 3.022 X-RAY DIFFRACTION 0.264 0.210 False True IGHV4 IGKV4 Kappa None None None None None 6mub M K 0 M carbohydrate BMA polysaccharide IMMUNE SYSTEM 10/22/18 Anti-HIV-1 Fab 2G12 + Man5 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wilson, I.A., Calarese, D.A., Stanfield, R.L. 2.503 X-RAY DIFFRACTION 0.280 0.245 False True unknown IGKV1 Kappa 1e-07 -9.54970862587178 Unknown TBD 7mjj F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7jv4 F G 0 C protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (one RBD open) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV7 Lambda None None None None None 6pzz K J 0 D protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5vzy H L 0 A peptide amyloid beta a4 protein IMMUNE SYSTEM 05/29/17 Crystal structure of crenezumab Fab in complex with Abeta HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Wang, W. 2.32 X-RAY DIFFRACTION 0.249 0.206 False True IGHV3 IGKV1 Kappa 3.2000000000000005e-09 -11.589048932503637 Unknown TBD 6u6m H L 0 NA NA NA NA IMMUNE SYSTEM 08/30/19 Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH840.1 MACACA MULATTA macaca mulatta macaca mulatta Chen, W.-H., Choe, M., Saunders, K.O., Joyce, M.G. 2.683 X-RAY DIFFRACTION 0.270 0.220 False True IGHV4 IGKV3 Kappa None None None None None 6emj A B 0 IMMUNE SYSTEM 10/02/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 2.3 X-RAY DIFFRACTION 0.211 0.165 False True IGHV4 IGKV1 Kappa None None None None None 7sfx C D 0 F peptide NA cd99 antigen peptide IMMUNE SYSTEM 10/04/21 10A1 Fab in complex with CD99 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Romero, L.A., Hattori, T., Koide, S. 3.1 X-RAY DIFFRACTION 0.248 0.226 False True IGHV6 IGLV3 Lambda None None None None None 6urm H L 0 F protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 10/23/19 Crystal structure of vaccine-elicited receptor-binding site targeting antibody LPAF-a.01 in complex with Hemagglutinin H1 A/California/04/2009 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhou, T., Cheung, S.F., Kwong, P.D. 2.65 X-RAY DIFFRACTION 0.262 0.215 False True IGHV2 IGLV3 Lambda None None None None None 4pir G NA 0 A protein 5-hydroxytryptamine receptor 3a TRANSPORT PROTEIN 05/09/14 X-ray structure of the mouse serotonin 5-HT3 receptor MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M.B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X.-D., Poitevin, F., Vogel, H., Nury, H. 3.5 X-RAY DIFFRACTION 0.257 0.217 False True IGHV1 None None None None None 2lve NA A 0 IMMUNOGLOBULIN 05/13/98 RECOMBINANT LEN HOMO SAPIENS homo sapiens Schiffer, M., Pokkuluri, P.R. 2.7 X-RAY DIFFRACTION 0.263 0.214 False True unknown unknown unknown None None None None None 6qd8 H L 0 F | E protein | protein NA | NA envelope glycoprotein | envelope glycoprotein,virion spike glycoprotein,ebov-gp1 VIRAL PROTEIN 01/01/19 EM structure of a EBOV-GP bound to 4M0368 neutralizing antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus | ebola virus Diskin, R., Cohen-Dvashi, H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6xjy C D 0 B nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - short time incubation with the epoxide substrate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 2.156 X-RAY DIFFRACTION 0.285 0.227 False True IGHV3 IGKV1 Kappa None None None None None 4krn A NA 0 IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain EgA1 LAMA GLAMA lama glama Ferguson, K.M., Schmitz, K.R. 1.553 X-RAY DIFFRACTION 0.226 0.199 False True IGHV1 None None None None None 7me7 B NA 0 R protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/06/21 CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb17 and Nb105 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D.J. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2jb6 B A 0 B Hapten T5C 2-{(1E,3Z,5E,7E)-7-[3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-1,3-DIHYDRO-2H-INDOL-2-YLIDENE]-4-METHYLHEPTA-1,3,5-TRIEN-1-YL}-3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-3H-INDOLIUM IMMUNE SYSTEM 12/03/06 Fab fragment in complex with small molecule hapten, crystal form-2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hillig, R.C., Baesler, S., Malawski, G., Badock, V., Bahr, I., Schirner, M., Licha, K. 2.85 X-RAY DIFFRACTION 0.282 0.229 False True IGHV1 IGLV2 Lambda 1.0999999999999999e-11 -14.95021525744087 Unknown TBD 7mlv NA K 0 D protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True NA IGKV6 Kappa None None None None None 7wuh K L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/08/22 SARS-CoV-2 Spike in complex with Fab of m31A7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7shy K L 0 H protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with omalizumab scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.230 0.173 False True IGHV3 IGKV1 Kappa None None None None None 6zdg H L 0 E protein NA spike glycoprotein VIRAL PROTEIN 06/14/20 Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4b41 B NA 0 IMMUNE SYSTEM 07/27/12 Crystal structure of an amyloid-beta binding single chain antibody G7 LAMA GLAMA lama glama Beringer, D.X., Dorresteijn, B., Rutten, L., Wienk, H., el Khattabi, M., Kroon-Batenburg, L.M.J., Verrips, C.T. 1.191 X-RAY DIFFRACTION 0.1619 0.1360 False True IGHV1 None None None None None 3rjq B NA 0 A protein c186 gp120 Viral Protein/Immune system 04/15/11 Crystal structure of anti-HIV llama VHH antibody A12 in complex with C186 gp120 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; LAMA GLAMA lama glama human immunodeficiency virus type 1 Chen, L., McLellan, J.S., Kwon, Y.D., Schmidt, S., Wu, X., Zhou, T., Yang, Y., Zhang, B., Forsman, A., Weiss, R.A., Verrips, T., Mascola, J., Kwong, P.D. 2.601 X-RAY DIFFRACTION 0.299 0.255 False True IGHV1 None None None None None 2w0l NA B 0 IMMUNE SYSTEM 08/19/08 CRYSTAL STRUCTURE OF THE MUTANT H8P FROM THE RECOMBINANT VARIABLE DOMAIN 6JAL2 HOMO SAPIENS homo sapiens RUDINO-PINERA, E., GONZALEZRUBIO-GARRIDO, P., HORJALES, E. 2.2 X-RAY DIFFRACTION 0.245 0.206 False False IGLV6 Lambda None None None None None 7po5 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/08/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 47C9 antibody Fab fragment HOMO SAPIENS; HUMAN CORONAVIRUS OC43 homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 2x7l G I 0 M protein hiv rev IMMUNE SYSTEM 03/01/10 Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element UNCLASSIFIED; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 BH10 unclassified unclassified human immunodeficiency virus type 3 DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M. 3.17 X-RAY DIFFRACTION 0.2500 0.2337 False True IGHV1 IGKV1 Kappa None None None None None 6p60 A B 0 E peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/03/20 Vaccine-elicited NHP FP-targeting neutralizing antibody A12V163-a.02 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.498 X-RAY DIFFRACTION 0.209 0.197 False True IGHV4 IGLV1 Lambda None None None None None 4m6n H L 0 IMMUNE SYSTEM 08/09/13 Crystal structure of anti-IL-23 antibody CNTO1959 at pH 6.5 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.230 0.180 False True IGHV5 IGLV1 Lambda None None None None None 6lkt A B 0 IMMUNE SYSTEM 06/17/20 Crystal structure of the Fab fragment of murine monoclonal antibody KH-1 against Human herpesvirus 6B MUS MUSCULUS mus musculus mus musculus Nishimura, M., Novita, B.D., Kato, T., Tjan, L.H., Wang, B., Wakata, A., Poetranto, A.L., Kawabata, A., Tang, H., Aoshi, T., Mori, Y. 1.8 X-RAY DIFFRACTION 0.196 0.165 False False IGHV1 IGKV4 Kappa None None None None None 7o85 NA Q 0 P | R protein | protein NA | NA protective antigen pa-63 | fab TOXIN 04/14/21 Anthrax toxin prepore in complex with the neutralizing Fab cAb29 BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus bacillus anthracis | mus musculus Hoelzgen, F., Zalk, R., Alcalay, R., Cohen-Schwartz, S., Garau, G., Shahar, A., Mazor, O., Frank, G.A. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7bq5 H L 0 A protein NA envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 03/24/20 ZIKV sE bound to mAb Z6 ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Dai, L., Qi, J., Gao, G.F. 2.99 X-RAY DIFFRACTION 0.275 0.261 False True IGHV4 IGKV1 Kappa None None None None None 6ot1 J K 0 E protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 2ht3 E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/25/06 Structure of the Escherichia coli ClC chloride channel Y445L mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.3 X-RAY DIFFRACTION 0.269 0.253 False False IGHV4 IGKV4 Kappa None None None None None 6xq0 B C 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S8V2-18 in complex with the influenza hemagglutinin head domain of A/California/7/2009(NYMC-X181)(H1N1) INFLUENZA A VIRUS (A/REASSORTANT/NYMC X-181A(A/NYMC X-157 X CALIFORNIA/07/2009)(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/reassortant/nymc x-181a(a/nymc x-157 x california/07/2009)(h1n1)) McCarthy, K.R., Harrison, S.C. 2.3 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGKV3 Kappa None None None None None 5vke A B 0 C protein ph-gated potassium channel kcsa IMMUNE SYSTEM/TRANSPORT PROTEIN 04/21/17 Open conformation of KcsA deep-inactivated STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Perozo, E., Cortes, D.M. 2.37 X-RAY DIFFRACTION 0.228 0.196 False False IGHV1 IGKV5 Kappa None None None None None 7n0g Z NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 05/25/21 CryoEm structure of SARS-CoV-2 spike protein (S-6P, 1-up) in complex with sybodies (Sb45) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Huang, R., Margulies, D. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3mug D C 0 C carbohydrate NAG polysaccharide IMMUNE SYSTEM 05/03/10 Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pejchal, R., Walker, L.M., Burton, D.R., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGLV2 Lambda None None None None None 6j5f H L 0 A protein envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 01/10/19 Complex structure of MAb 4.2-scFv with tick-borne encephalitis virus envelope protein Domain III TICK-BORNE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus tick-borne encephalitis virus Yang, X., Qi, J., Peng, R., Dai, L., Gould, E.A., Tien, P., Gao, G.F. 1.801 X-RAY DIFFRACTION 0.192 0.179 False True IGHV1 IGKV12 Kappa None None None None None 6osv H L 0 K protein tyrosine-protein kinase transmembrane receptor ror2 immune sytem/transferase 04/01/20 Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2 ORYCTOLAGUS CUNICULUS; HOMO SAPIENS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Park, H., Rader, C. 1.34 X-RAY DIFFRACTION 0.189 0.162 False True IGHV3 IGKV1 Kappa None None None None None 1yzz A NA 0 UNKNOWN FUNCTION 03/01/05 Humanized caban33 at room temperature CAMELUS DROMEDARIUS camelus dromedarius Conrath, K., Vincke, C., Stijlemans, B., Schymkowitz, J., Decanniere, K., Muyldermans, S., Loris, R. 2.7 X-RAY DIFFRACTION 0.293 0.233 False True IGHV1 None None None None None 6fys G NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 7r1z C NA 0 A protein NA activity-regulated cytoskeleton-associated protein SIGNALING PROTEIN 02/03/22 C-terminal domain of hArc in complex with nanobodies H11 and C11, collapsed crystal form VICUGNA PACOS; RATTUS NORVEGICUS vicugna pacos rattus norvegicus Markusson, S., Kursula, P. 1.94 X-RAY DIFFRACTION 0.243 0.197 False True IGHV1 NA NA None None None None None 5vod H L 0 C | E protein | protein NA | NA envelope glycoprotein ul128 | envelope glycoprotein ul131a Viral Protein/Immune System 05/02/17 Crystal structure of HCMV Pentamer in complex with neutralizing antibody 9I6 HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN); HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS; HUMAN CYTOMEGALOVIRUS (STRAIN AD169); HUMAN CYTOMEGALOVIRUS (STRAIN 5508) homo sapiens homo sapiens human cytomegalovirus (strain ad169) | human cytomegalovirus (strain merlin) Malito, E., Chandramouli, S. 5.9 X-RAY DIFFRACTION 0.299 0.258 False True IGHV5 IGKV2 Kappa None None None None None 1a6v I M 0 I Hapten NPC 4-HYDROXY-3-NITROPHENYLACETYL-EPSILON-AMINOCAPROIC ACID ANION IMMUNOGLOBULIN 03/03/98 B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-3-NITROPHENYL) ACETATE COMPOUND MUS MUSCULUS mus musculus mus musculus mus musculus Simon, T., Henrick, K., Hirshberg, M., Winter, G. 1.8 X-RAY DIFFRACTION unknown 0.296 False True IGHV1 IGLV1 Lambda None None None None None 5u0u C c 0 IMMUNE SYSTEM 11/27/16 Crystal Structure of DH270.1 (unliganded, single-chain Fv) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens Fera, D., Harrison, S.C. 3.428 X-RAY DIFFRACTION 0.282 0.254 True True unknown unknown unknown None None None None None 7jvr E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/22/20 Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein ESCHERICHIA COLI; HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Zhuang, Y., Xu, P., Mao, C., Wang, L., Krumm, B., Zhou, X.E., Huang, S., Liu, H., Cheng, X., Huang, X.-P., Sheng, D.-D., Xu, T., Liu, Y.-F., Wang, Y., Guo, J., Jiang, Y., Jiang, H., Melcher, K., Roth, B.L., Zhang, Y., Zhang, C., Xu, H.E. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6iec J K 0 I protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R17 RIFT VALLEY FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.281 0.241 False True IGHV3 IGLV3 Lambda None None None None None 4yo0 A B 0 E peptide pa14 peptide IMMUNE SYSTEM 03/11/15 Crystal structure of monoclonal anti-human podoplanin antibody NZ-1 with bound PA peptide RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus homo sapiens Fujii, Y., Kitago, Y., Arimori, T., Takagi, J. 1.56 X-RAY DIFFRACTION 0.214 0.179 False True IGHV5 IGLV3 Lambda None None None None None 3qxu C NA 0 IMMUNE SYSTEM 03/02/11 Free Structure of an Anti-Methotrexate CDR1-3 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.8 X-RAY DIFFRACTION 0.214 0.182 False True IGHV1 None None None None None 7lzp H NA 0 D protein NA botulinum neurotoxin a light chain ANTITOXIN 03/10/21 LC/A-JPU-B9-JPU-A11-JPU-G11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.86 X-RAY DIFFRACTION 0.273 0.235 False True unknown unknown unknown None None None None None 2i9l D C 0 J protein virion membrane protein m25 IMMUNE SYSTEM/VIRAL PROTEIN 09/05/06 Structure of Fab 7D11 from a neutralizing antibody against the poxvirus L1 protein VACCINIA VIRUS; MUS MUSCULUS mus musculus mus musculus vaccinia virus Su, H.P., Golden, J.W., Gittis, A.G., Moss, B., Hooper, J.W., Garboczi, D.N. 3.1 X-RAY DIFFRACTION 0.259 0.240 False False IGHV1 IGKV8 Kappa None None None None None 6eqc F f 0 C protein hexon protein VIRAL PROTEIN 10/12/17 Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon MUS MUSCULUS; HUMAN ADENOVIRUS 5 mus musculus human adenovirus 5 Schmid, M., Ernst, P., Honegger, A., Suomalainen, M., Zimmermann, M., Braun, L., Stauffer, S., Thom, C., Dreier, B., Eibauer, M., Kipar, A., Vogel, V., Greber, U.F., Medalia, O., Plueckthun, A. 7.4 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 5vob H L 0 D | B protein | protein NA | NA envelope glycoprotein ul130 | envelope glycoprotein l Viral Protein/Immune System 05/02/17 Crystal structure of HCMV Pentamer in complex with neutralizing antibody 8I21 HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS (STRAIN AD169); HUMAN CYTOMEGALOVIRUS (STRAIN 5508); HUMAN CYTOMEGALOVIRUS; HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN) homo sapiens homo sapiens human cytomegalovirus (strain merlin) | human cytomegalovirus (strain 5508) Malito, E., Chandramouli, S. 3.02 X-RAY DIFFRACTION 0.237 0.190 False True IGHV3 IGKV3 Kappa 1.5e-10 -13.40220943473902 SPR TBD 6n5e G F 0 B protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/21/18 Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope INFLUENZA A VIRUS; MUS MUSCULUS influenza a virus mus musculus influenza a virus Bajic, G., Schmidt, A.G. 3.0 X-RAY DIFFRACTION 0.287 0.250 False True IGHV5 IGLV1 Lambda None None None None None 5hyq B A 0 IMMUNE SYSTEM 02/01/16 Cetuximab Fab in complex with amidated meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.477 X-RAY DIFFRACTION 0.208 0.166 False True IGHV2 IGKV5 Kappa 1.5000000000000002e-07 -9.309477166508257 Unknown TBD 6x40 J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 2.86 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 7ldj G NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/13/21 SARS-CoV-2 receptor binding domain in complex with WNb-2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Adair, A., Tham, W.H. 2.36 X-RAY DIFFRACTION 0.268 0.210 False True IGHV1 NA NA None None None None None 4u7s B NA 0 IMMUNE SYSTEM 07/31/14 Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) Crystallized for 5 months LAMA GLAMA lama glama Legler, P.M. 2.07 X-RAY DIFFRACTION 0.242 0.232 False True IGHV1 None None None None None 6fy3 H L 0 P peptide cap45 v2 peptide IMMUNE SYSTEM 03/10/18 Crystal structure of a V2-directed, RV144 vaccine-like antibody from HIV-1 infection, CAP228-3D, bound to a heterologous V2 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Moore, P.L., Morris, L. 2.6 X-RAY DIFFRACTION 0.250 0.220 False True IGHV5 IGLV6 Lambda None None None None None 6uy3 A a 0 a Hapten MTX METHOTREXATE ANTITUMOR PROTEIN 11/11/19 Structure of anti-hCD33 conditional scFv with methotrexate CAMELIDAE MIXED LIBRARY camelidae mixed library Kimberlin, C.R., Park, S. 2.0 X-RAY DIFFRACTION 0.221 0.189 True True unknown unknown unknown None None None None None 2r1w B A 0 B carbohydrate KDA (3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID)-2-O-ALLYL IMMUNE SYSTEM 08/23/07 Crystal structure of S25-2 Fab in complex with Kdo analogues MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 1.7 X-RAY DIFFRACTION 0.246 0.219 False False IGHV7 IGKV8 Kappa 2.4999999999999998e-05 -6.278333142280578 Unknown TBD 7c8v A NA 0 B protein NA spike glycoprotein PROTEIN BINDING 06/03/20 Structure of sybody SR4 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD) SYNTHETIC CONSTRUCT; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 synthetic construct severe acute respiratory syndrome coronavirus2 Li, T., Yao, H., Cai, H., Qin, W., Li, D. 2.15 X-RAY DIFFRACTION 0.224 0.184 False True IGHV1 NA NA None None None None None 7eh5 D O 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/28/21 Cryo-EM structure of SARS-CoV-2 S-D614G variant in complex with neutralizing antibodies, RBD-chAb15 and RBD-chAb45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Chang, Y.C., Wu, H.C., Hsu, S.T.D. 4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV5 Kappa None None None None None 2gfb H G 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 7eo2 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/21/21 Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p HOMO SAPIENS homo sapiens homo sapiens | homo sapiens He, Y., Xu, Z., Ikuta, T. 2.89 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5mp5 A B 0 K peptide microtubule-associated protein tau IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M. 2.31 X-RAY DIFFRACTION 0.277 0.235 False False IGHV1 IGKV8 Kappa None None None None None 3jwo H L 0 A protein hiv-1 gp120 envelope glycoprotein VIRAL PROTEIN 09/18/09 Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pancera, M., Majeed, S., Huang, C.C., Kwon, Y.D., Zhou, T., Robinson, J.E., Sodroski, J., Wyatt, R., Kwong, P.D. 3.51 X-RAY DIFFRACTION 0.273 0.257 False True IGHV1 IGKV1 Kappa None None None None None 5d9q H L 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 08/18/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Ward, A.B., Wilson, I.A. 4.4 X-RAY DIFFRACTION 0.320 0.290 False True IGHV4 IGLV3 Lambda None None None None None 7ws3 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5fuz H L 0 02/01/16 Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life HOMO SAPIENS homo sapiens homo sapiens Adams, R., Ceska, T. 2.68 X-RAY DIFFRACTION 0.2509 0.2119 False True IGHV3 IGKV1 Kappa None None None None None 7k39 L K 0 E | F protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation A, neutral pH-like INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7wro H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/27/22 Local structure of BD55-3372 and delta spike Homo sapiens; Severe acute respiratory syndrome coronavirus homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Liu, P.L. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 4yhk H L 0 H Hapten 4CC N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine IMMUNE SYSTEM 02/27/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schiele, F., Nar, H. 2.21 X-RAY DIFFRACTION 0.234 0.174 False True IGHV1 IGKV1 Kappa None None None None None 7mep I G 0 E protein NA bg505 sosipv5.2(7s) - gp120 VIRAL PROTEIN 04/07/21 BG505 SOSIP.v5.2(7S) in complex with the monoclonal antibodies Rh.33172 mAb.1 and RM19R MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS macaca mulatta macaca mulatta human immunodeficiency virus Antanasijevic, A., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7ldj H NA 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/13/21 SARS-CoV-2 receptor binding domain in complex with WNb-2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Adair, A., Tham, W.H. 2.36 X-RAY DIFFRACTION 0.268 0.210 False True IGHV1 NA NA None None None None None 7mf7 C D 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.231 0.203 False True IGHV3 IGLV3 Lambda None None None None None 6w0b A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Open-gate KcsA soaked in 2 mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 3.604 X-RAY DIFFRACTION 0.236 0.190 False True IGHV1 IGKV5 Kappa None None None None None 6vi1 E D 0 M peptide NA terminase, large subunit IMMUNE SYSTEM 01/11/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 2.4 X-RAY DIFFRACTION 0.239 0.189 False True IGHV3 IGKV1 Kappa None None None None None 7cw3 m n 0 T | S protein | protein NA | NA capsid protein | capsid protein VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG (subregion around icosahedral 2-fold vertex) CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 9.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 7t4q J K 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with neutralizing fabs 2C12, 7I13 and 13H11 HUMAN BETAHERPESVIRUS 5; HOMO SAPIENS homo sapiens homo sapiens human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6bpe E F 0 D protein reticulocyte binding protein 2, putative CELL INVASION 11/22/17 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 6H1 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus mus musculus plasmodium vivax (strain salvador i) Gruszczyk, J., Chan, L.J., Tham, W.H. 3.34 X-RAY DIFFRACTION 0.367 0.318 False False IGHV5 IGKV6 Kappa None None None None None 2kqm NA B 11 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 2otu D C 0 Q peptide peptide antigen IMMUNE SYSTEM 02/09/07 Crystal structure of Fv polyglutamine complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Li, P. 1.68 X-RAY DIFFRACTION 0.214 0.200 False True IGHV5 IGLV3 Lambda None None None None None 7kjh B NA 0 D protein NA surface protein p12p UNKNOWN FUNCTION 10/26/20 Plasmodium falciparum protein Pf12p bound to nanobody B9 VICUGNA PACOS; PLASMODIUM FALCIPARUM vicugna pacos plasmodium falciparum Dietrich, M.H., Tham, W.H. 2.0 X-RAY DIFFRACTION 0.217 0.180 False True IGHV1 NA NA None None None None None 4ttd C D 0 B protein lysozyme c IMMUNE SYSTEM 06/20/14 Structure of a lysozyme antibody complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Wensley, B. 2.15 X-RAY DIFFRACTION 0.279 0.255 False True IGHV3 IGLV1 Lambda None None None None None 4c2i M N 0 A protein envelope protein VIRUS 08/18/13 Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4 HOMO SAPIENS; DENGUE VIRUS 1 homo sapiens homo sapiens dengue virus 1 Fibriansah, G., Tan, J.L., de Alwis, R., Smith, S.A., Ng, T.-S., Kostyuchenko, V.A., Ibarra, K.D., Harris, E., de Silva, A., Crowe Junior, J.E., Lok, S.-M. 6.0 ELECTRON MICROSCOPY False False IGHV3 IGLV1 Lambda None None None None None 6x04 J NA 0 I protein NA nucleoporin nup133 STRUCTURAL PROTEIN 05/15/20 Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN5 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 2.68 X-RAY DIFFRACTION 0.261 0.244 False True IGHV1 NA NA None None None None None 3u36 H L 0 IMMUNE SYSTEM 10/04/11 Crystal Structure of PG9 Fab HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Kwong, P.D. 3.281 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV2 Lambda None None None None None 5dub H L 0 P peptide peptide IMMUNE SYSTEM 09/18/15 Context-independent anti-hypusine antibody FabHpu98 in complex with deoxyhypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Zhai, Q., Carter, P.J. 2.0 X-RAY DIFFRACTION 0.220 0.181 False True IGHV1 IGKV1 Kappa None None None None None 7l0l G J 0 E | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral protein 12/11/20 Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer HOMO SAPIENS; INFLUENZA A VIRUS (A/CANADA/720/2005(H2N2)) homo sapiens homo sapiens influenza a virus (a/canada/720/2005(h2n2)) | influenza a virus (a/canada/720/2005(h2n2)) Gorman, J., Kwong, P.D. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5gs0 X Y 0 IMMUNE SYSTEM 08/13/16 Crystal structure of the complex of TLR3 and bi-specific diabody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 3.275 X-RAY DIFFRACTION 0.248 0.192 False True IGHV3 IGKV10 Kappa None None None None None 7oay B NA 0 A protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 2.34 X-RAY DIFFRACTION 0.228 0.192 False False IGHV1 NA NA None None None None None 1ub5 H L 0 H Hapten SPB 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID IMMUNE SYSTEM 03/30/03 Crystal structure of Antibody 19G2 with hapten at 100K MUS MUSCULUS mus musculus mus musculus mus musculus Beuscher, A.B., Wirsching, P., Lerner, R.A., Janda, K., Stevens, R.C. 2.0 X-RAY DIFFRACTION 0.267 0.248 False True IGHV5 IGKV2 Kappa None None None None None 7jum I i 0 B protein NA gametocyte surface protein p230 CELL INVASION 08/20/20 Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01 PLASMODIUM FALCIPARUM (ISOLATE 3D7); HOMO SAPIENS homo sapiens plasmodium falciparum (isolate 3d7) Tolia, N., Tang, W.K. 1.998 X-RAY DIFFRACTION 0.233 0.191 True True unknown unknown unknown None None None None None 5jxe D C 0 B protein programmed cell death protein 1 IMMUNE SYSTEM 05/13/16 Human PD-1 ectodomain complexed with Pembrolizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Na, Z., Bharath, S.R., Song, H. 2.9 X-RAY DIFFRACTION 0.286 0.261 False True IGHV1 IGKV3 Kappa None None None None None 4h0g A a 0 IMMUNE SYSTEM 09/08/12 Crystal structure of mimicry-recognizing native 2D10 scFv MUS MUSCULUS mus musculus Tapryal, S., Gaur, V., Kaur, K.J., Salunke, D.M. 2.3 X-RAY DIFFRACTION 0.275 0.262 True True unknown unknown unknown None None None None None 7mmn D E 0 B protein NA fusion glycoprotein f1,fibritin IMMUNE SYSTEM/VIRAL PROTEIN 04/29/21 Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; ENTEROBACTERIA PHAGE T4 homo sapiens homo sapiens human respiratory syncytial virus,enterobacteria phage t4 Harshbarger, W., Malito, E. 3.57 X-RAY DIFFRACTION 0.245 0.202 False True IGHV3 IGKV1 Kappa None None None None None 4evn E F 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 6plk I M 0 F protein env ANTIVIRAL PROTEIN 07/01/19 Crystal structure of ZIKV-116 Fab in complex with ZIKV envelope DIII HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhao, H., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.3 X-RAY DIFFRACTION 0.211 0.167 False True IGHV3 IGKV1 Kappa None None None None None 7s8g h l 0 NA NA NA NA ANTIVIRAL PROTEIN,IMMUNE SYSTEM 09/17/21 Structure of anti-LASV Fab 25.10C with FNQI mutation HOMO SAPIENS homo sapiens homo sapiens Hastie, K.M., Enriquez, A.S. 2.57 X-RAY DIFFRACTION 0.263 0.220 False False IGHV3 IGKV1 Kappa None None None None None 2iq9 H L 0 IMMUNE SYSTEM 10/13/06 PFA2 FAB fragment, triclinic apo form MUS MUSCULUS mus musculus mus musculus Gardberg, A.S., Dealwis, C. 2.3 X-RAY DIFFRACTION 0.278 0.211 False False IGHV8 IGKV1 Kappa None None None None None 4odh H L 0 IMMUNE SYSTEM 01/10/14 Crystal structure of human Fab CAP256-VRC26.UCA, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 2.894 X-RAY DIFFRACTION 0.244 0.224 False True IGHV3 IGLV1 Lambda None None None None None 7mzj F E 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 93 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.4 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGLV1 Lambda None None None None None 4gxu W X 0 K protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/04/12 Crystal structure of antibody 1F1 bound to the 1918 influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 3.294 X-RAY DIFFRACTION 0.255 0.219 False True IGHV3 IGLV1 Lambda 6.24e-09 SPR 23236279 1nfd H G 0 D protein n15 alpha-beta t-cell receptor COMPLEX (IMMUNORECEPTOR/IMMUNOGLOBULIN) 08/04/97 AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY MUS MUSCULUS mus musculus mus musculus mus musculus Wang, J.-H., Lim, K., Smolyar, A., Teng, M.-K., Sacchittini, J., Reinherz, E.L. 2.8 X-RAY DIFFRACTION 0.309 0.243 False True IGHV6 IGKV10 Kappa None None None None None 3mlx I M 0 Q peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with an MN V3 peptide HOMO SAPIENS; HIV-1 M:B_MN homo sapiens homo sapiens hiv-1 m Kong, X.-P. 1.9 X-RAY DIFFRACTION 0.228 0.192 False False IGHV4 IGLV1 Lambda None None None None None 6xxo A NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB8, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 1.5 X-RAY DIFFRACTION 0.183 0.162 False True IGHV1 None None None None None 7m6g H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, BG7-15 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5w1k L K 0 J protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV3 IGKV1 Kappa None None None None None 7lxz N O 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2L28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7n0g Y NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 05/25/21 CryoEm structure of SARS-CoV-2 spike protein (S-6P, 1-up) in complex with sybodies (Sb45) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Huang, R., Margulies, D. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5cd3 G H 0 IMMUNE SYSTEM 07/02/15 Structure of immature VRC01-class antibody DRVIA7 HOMO SAPIENS homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.234 False True unknown IGKV1 Kappa None None None None None 7qnx A B 0 E protein NA surface glycoprotein VIRAL PROTEIN 12/23/21 The receptor binding domain of SARS-CoV-2 spike glycoprotein in complex with Beta-55 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.92 X-RAY DIFFRACTION 0.266 0.229 False True IGHV4 IGKV1 Kappa None None None None None 3lrh NA O 0 P peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 7nfr B NA 0 A protein NA polymerase basic protein 2 VIRAL PROTEIN 02/07/21 Fujian capmidlink domain in complex with Nb8194 INFLUENZA A VIRUS (A/DUCK/FUJIAN/13/2002(H5N1)); HOMO SAPIENS homo sapiens influenza a virus (a/duck/fujian/13/2002(h5n1)) Keown, J.R., Grimes, J.M., Fodor, E. 1.88 X-RAY DIFFRACTION 0.245 0.195 False True IGHV3 NA NA None None None None None 5h8d A NA 0 IMMUNE SYSTEM 12/23/15 Crystal structure of an ASC binding nanobody LAMA GLAMA lama glama Lu, A., Schmidt, F.I., Ruan, J., Tang, C., Wu, H., Ploegh, H.L. 1.89 X-RAY DIFFRACTION 0.203 0.169 False True IGHV1 None None None None None 1gpo H L 0 IMMUNOGLOBULIN 03/27/97 CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT MUS MUSCULUS synthetic construct mus musculus Schiweck, W., Skerra, A. 1.95 X-RAY DIFFRACTION 0.283 0.214 False True IGHV4 IGKV6D Kappa None None None None None 7beo H L 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253H55L and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 3.19 X-RAY DIFFRACTION 0.274 0.234 False True IGHV1 IGKV3 Kappa None None None None None 6nfn B A 0 B Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 6awp B C 0 A protein NA sodium-dependent serotonin transporter TRANSPORT PROTEIN 09/06/17 X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Gouaux, E. 3.8 X-RAY DIFFRACTION 0.269 0.245 False True IGHV1 IGKV6 Kappa None None None None None 2kh2 B b 43 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7dk2 A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/22/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M., Chen, S. 3.0 X-RAY DIFFRACTION 0.304 0.258 False True IGHV3 IGKV1 Kappa None None None None None 6amj H L 0 IMMUNE SYSTEM 08/09/17 CAT192 Fab Wild Type HOMO SAPIENS homo sapiens homo sapiens Lord, D.M., Wei, R.R. 2.49 X-RAY DIFFRACTION 0.262 0.206 False True IGHV3 IGKV1 Kappa None None None None None 7nj5 F NA 0 A protein NA polymerase acidic protein VIRAL PROTEIN 02/16/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (a/brevigmission/1/1918(h1n1)) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.63 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1pz5 B A 0 C peptide octapeptide (mdwnmhaa) IMMUNE SYSTEM 07/09/03 Structural basis of peptide-carbohydrate mimicry in an antibody combining site MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Vyas, N.K., Vyas, M.N., Chervenak, M.C., Bundle, D.R., Pinto, B.M., Quiocho, F.A. 1.8 X-RAY DIFFRACTION 0.254 0.219 False False IGHV6 IGKV1 Kappa 4.00e-06 -7.8 ITC 25 14645714 4yzf K L 0 D protein band 3 anion transport protein IMMUNE SYSTEM 03/25/15 Crystal structure of the anion exchanger domain of human erythrocyte Band 3 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alguel, Y., Arakawa, T., Yugiri, T.K., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Suno, C.I., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A.D., Kobayashi, T., Hamasaki, N., Iwata, S. 3.5 X-RAY DIFFRACTION 0.290 0.274 False False IGHV8 IGKV3 Kappa None None None None None 2mkw NA A 18 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 5ibl H L 0 B | E protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 02/22/16 Human antibody 6639 in complex with influenza hemagglutinin H1 X-181 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Raymond, D.D., Harrison, S.C. 3.39 X-RAY DIFFRACTION 0.257 0.214 False True IGHV5 IGKV3 Kappa None None None None None 2kh2 B b 32 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6glx C D 0 B protein galectin-10 SUGAR BINDING PROTEIN 05/23/18 Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 4E8 HOMO SAPIENS; LAMA GLAMA lama glama lama glama homo sapiens Verstraete, K., Verschueren, K., Savvides, S.N. 3.396 X-RAY DIFFRACTION 0.360 0.303 False True IGHV4 IGLV3 Lambda None None None None None 3juy A a 0 IMMUNE SYSTEM 09/15/09 Crystal Structure of a 3B3 Variant, a Broadly Neutralizing HIV-1 scFv Antibody HOMO SAPIENS homo sapiens Clark, K.R., Walsh, S.T. 2.5 X-RAY DIFFRACTION 0.260 0.195 True True unknown unknown unknown None None None None None 5cez D E 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 07/08/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with an early putative precursor of the PGT121 family at 3.0 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wilson, I.A., Garces, F. 3.031 X-RAY DIFFRACTION 0.266 0.233 False True unknown unknown unknown None None None None None 6mg7 H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 09/13/18 Crystal structure of the RV144 C1-C2 specific antibody CH54 Fab in complex with HIV-1 CLADE A/E GP120 and M48U1 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Van, V., Tolbert, W.D., Pazger, M. 2.91 X-RAY DIFFRACTION 0.307 0.250 False True IGHV1 IGKV1 Kappa None None None None None 6y0e B NA 0 NA NA NA NA IMMUNE SYSTEM 02/07/20 Nbe LBM LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.5 X-RAY DIFFRACTION 0.180 0.161 False True IGHV1 NA NA None None None None None 4krm D NA 0 C protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.655 X-RAY DIFFRACTION 0.244 0.208 False True IGHV1 None None None None None 7sp7 C NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus hyaluronan synthase inhibited by UDP PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2; LAMA GLAMA lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5f97 F NA 0 B protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group A type 1 hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.62 X-RAY DIFFRACTION 0.237 0.188 False True IGHV1 None None None None None 7cwl I K 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 SARS-CoV-2 spike protein and P17 fab complex with one RBD in close state SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3p0y H L 0 A protein epidermal growth factor receptor IMMUNE SYSTEM 09/29/10 anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Shia, S. 1.8 X-RAY DIFFRACTION 0.215 0.181 False True IGHV3 IGKV1 Kappa 1.92e-09 -12.36 SPR 37 22014573 6mns A B 0 Q peptide envelope glylcoprotein IMMUNE SYSTEM 10/02/18 Rhesus macaque anti-HIV V3 antibody DH753 with gp120 V3 ZAM18 peptide MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Nicely, N.I. 2.7 X-RAY DIFFRACTION 0.256 0.170 False True IGHV3 IGLV1 Lambda None None None None None 6ehv X x 0 IMMUNE SYSTEM 09/15/17 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery HOMO SAPIENS homo sapiens Hargreaves, D. 2.54 X-RAY DIFFRACTION 0.314 0.275 True True unknown unknown unknown None None None None None 2mmx NA A 15 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6avr H L 0 B | A protein | protein NA | NA integrin beta-3 | integrin alpha-v SIGNALING PROTEIN 09/04/17 Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D. 35 ELECTRON MICROSCOPY False True IGHV5 IGKV5 Kappa None None None None None 6ibb D NA 0 C protein succinate receptor 1 MEMBRANE PROTEIN 11/29/18 Crystal structure of the rat isoform of the succinate receptor SUCNR1 (GPR91) in complex with a nanobody RATTUS NORVEGICUS; VICUGNA PACOS vicugna pacos rattus norvegicus Haffke, M., Jaakola, V.-P. 2.12 X-RAY DIFFRACTION 0.216 0.178 False True IGHV1 None None None None None 7jtr D d 0 C protein NA maltose/maltodextrin-binding periplasmic protein SUGAR BINDING PROTEIN/IMMUNE SYSTEM 08/18/20 Complex of maltose-binding protein (MBP) with single-chain Fv (scFv) MUS MUSCULUS; ESCHERICHIA COLI mus musculus escherichia coli Loll, P.J. 2.5 X-RAY DIFFRACTION 0.237 0.201 True True unknown unknown unknown None None None None None 4gxu U V 0 I protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/04/12 Crystal structure of antibody 1F1 bound to the 1918 influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 3.294 X-RAY DIFFRACTION 0.255 0.219 False True IGHV3 IGLV1 Lambda 6.24e-09 SPR 23236279 7q9f J K 0 C protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-50 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2kqn NA B 8 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5esz A B 0 C protein 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase,envelope glycoprotein gp160 IMMUNE SYSTEM 11/17/15 Crystal Structure of Broadly Neutralizing Antibody CH04, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade AE Strain A244 HOMO SAPIENS; HAEMOPHILUS INFLUENZAE homo sapiens homo sapiens haemophilus influenzae, human immunodeficiencyvirus 1, haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd) Gorman, J., Yang, M., Kwong, P.D. 4.191 X-RAY DIFFRACTION 0.282 0.252 False True IGHV3 IGKV3 Kappa None None None None None 4hk0 C D 0 IMMUNE SYSTEM 10/14/12 UCA Fab (unbound) from CH65-CH67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 2.497 X-RAY DIFFRACTION 0.258 0.206 False True IGHV1 IGLV3 Lambda None None None None None 6vrk B C 0 A protein sodium-dependent serotonin transporter TRANSPORT PROTEIN 02/07/20 Cryo-EM structure of the wild-type human serotonin transporter complexed with Br-paroxetine and 8B6 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Navratna, V., Yang, D. 4.1 ELECTRON MICROSCOPY False True IGHV1 IGKV6 Kappa None None None None None 7t0i D C 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-39 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.1 X-RAY DIFFRACTION 0.225 0.180 False True IGHV7 IGKV8 Kappa None None None None None 4xzu E F 0 G protein coagulation factor viii IMMUNE SYSTEM 02/05/15 Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Spiegel, P.C., Wuerth, M.E. 2.61 X-RAY DIFFRACTION 0.267 0.199 False False IGHV9 IGKV4 Kappa None None None None None 7jvc H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2A4 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 7mw6 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with three RBDs up in complex with the Fab fragment of human neutralizing antibody clone 2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5f8q C NA 0 A protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain S831 in complex with Nanobody Nb-ER19 HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.59 X-RAY DIFFRACTION 0.230 0.195 False True IGHV1 None None None None None 6i8s F J 0 B protein plasminogen activator inhibitor 1 BLOOD CLOTTING 11/21/18 Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens Vousden, K.A., Lundqvist, T., Popovic, B. 2.9 X-RAY DIFFRACTION 0.243 0.219 False True IGHV1 IGKV1 Kappa None None None None None 7n9b F NA 0 C | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/17/21 Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB21 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Sun, D., Zhang, C., Shi, Y. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2kqm NA A 0 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6ani I M 0 IMMUNE SYSTEM 08/13/17 Coltuximab Fab in complex with anti-Kappa VHH domain LAMA GLAMA; HOMO SAPIENS homo sapiens homo sapiens Ereno Orbea, J., Sicard, T., Julien, J.-P. 2.4 X-RAY DIFFRACTION 0.286 0.245 False True IGHV1 IGKV4 Kappa 7.8e-09 -11.061162015777013 Unknown TBD 7d0d G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-3C12_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, R.K., Ju, B., Yu, J.F., Zhang, Y.Y., Liu, N., Wang, H.W., Wang, X.Q., Zhang, L.Q., Zhou, Q. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV4 Kappa None None None None None 7rth B A 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 2q1e NA D 0 PROTEIN FIBRIL 05/24/07 Altered dimer interface decreases stability in an amyloidogenic kappa1 Bence Jones protein. HOMO SAPIENS homo sapiens Thompson, J.R., Ramirez-Alvarado, M., Baden, E.M. 2.55 X-RAY DIFFRACTION 0.206 0.165 False True IGKV1 Kappa None None None None None 6ea5 M N 0 B | C | D protein | protein | protein NA | NA | NA glycoprotein | envelope glycoprotein | glycoprotein VIRAL PROTEIN/immune system 08/02/18 Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878 BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus | bundibugyo ebolavirus | bundibugyo ebolavirus King, L.B., West, B.R., Moyer, C.L., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O. 4.75 X-RAY DIFFRACTION 0.305 0.295 False True IGHV3 IGKV1 Kappa None None None None None 7wdf D E 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with two S3H3 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 5n4g H L 0 IMMUNE SYSTEM 02/10/17 human Fab fragment 12E1 against NHBA from Neisseria meningitidis HOMO SAPIENS homo sapiens homo sapiens Maritan, M., Malito, E. 2.75 X-RAY DIFFRACTION 0.268 0.186 False True IGHV1 IGKV2 Kappa None None None None None 4cad H G 0 I protein ras and a-factor converting enzyme 1, rce1 PROTEIN BINDING 10/08/13 Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 METHANOCOCCUS MARIPALUDIS; MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis Kulkarni, K., Manolaridis, I., Dodd, R.B., Cronin, N., Ogasawara, S., Iwata, S., Barford, D. 2.5 X-RAY DIFFRACTION 0.2669 0.2262 False False IGHV1 IGKV12 Kappa None None None None None 6um6 K L 0 I protein ch848 10.17dt gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunder, K.O., Haynes, B.F. 4.3 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 6e8v c d 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False False IGHV1 IGLV1 Lambda None None None None None 6fys E NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 7wd0 c d 0 B protein NA light chain of s5d2 fab VIRAL PROTEIN 12/20/21 SARS-CoV-2 Beta spike in complex with two S5D2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.3 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 5tzt H L 0 C protein leukocyte surface antigen cd47 IMMUNE SYSTEM 11/22/16 Crystal structure of human CD47 ECD bound to Fab of C47B161 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cardoso, R.M.F. 2.89 X-RAY DIFFRACTION 0.328 0.257 False True IGHV1 IGKV1 Kappa 2.8700000000000002e-09 -11.653534133424982 SPR TBD 4kkb C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 20mM fluoride and 20mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.021 X-RAY DIFFRACTION 0.268 0.236 False True IGHV4 IGKV4 Kappa None None None None None 2uyl Y X 0 IMMUNE SYSTEM 04/10/07 Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1 MUS MUSCULUS mus musculus mus musculus Ahmed, F., Haouz, A., Nato, F., Fournier, J.M., Alzari, P.M. 2.5 X-RAY DIFFRACTION 0.257 0.211 False False IGHV1 IGKV1 Kappa None None None None None 5my6 B NA 0 A protein receptor tyrosine-protein kinase erbb-2 TRANSFERASE 01/25/17 Crystal structure of a HER2-Nb complex HOMO SAPIENS; CAMELUS DROMEDARIUS camelus dromedarius homo sapiens Sterckx, Y.G.-J., D'Huyvetter, M., Devoogdt, N. 2.246 X-RAY DIFFRACTION 0.220 0.185 False True IGHV1 3.9900000000000005e-09 -11.458323083855877 SPR TBD 6w05 H L 0 P peptide NA npna2 peptide IMMUNE SYSTEM 02/29/20 Crystal structure of Fab356 in complex with NPNA2 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 2.516 X-RAY DIFFRACTION 0.256 0.209 False True IGHV3 IGKV3 Kappa None None None None None 7cn2 I i 0 F protein NA major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 07/29/20 Subparticle refinement of human papillomavirus type 16 pesudovirus in complex with H16.001 Fab HUMAN PAPILLOMAVIRUS TYPE 16; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human papillomavirus type 16 He, M.Z., Li, S.W. 3.43 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 4jm4 H L 0 IMMUNE SYSTEM 03/13/13 Crystal Structure of PGT 135 Fab HOMO SAPIENS homo sapiens homo sapiens Kong, L., Wilson, I.A. 1.751 X-RAY DIFFRACTION 0.245 0.207 False True IGHV4 IGKV3 Kappa None None None None None 1e6j H L 0 P protein capsid protein p24 HIV CAPSID PROTEIN (P24) 08/18/00 Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (CLONE 12); MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus type 1(clone 12) Berthet-Colominas, C., Monaco, S., Novelli, A., Sibai, G., Mallet, F., Cusack, S. 3.0 X-RAY DIFFRACTION 0.284 0.210 False False IGHV1 IGKV4 Kappa 2.90e-08 -10.28 SPR 11080628 4u6h A B 0 E protein protein l1 IMMUNE SYSTEM 07/29/14 Vaccinia L1/M12B9-Fab complex VACCINIA VIRUS; MUS MUSCULUS mus musculus mus musculus vaccinia virus Matho, M.H., Schlossman, A., Zajonc, D.M. 3.1 X-RAY DIFFRACTION 0.265 0.209 False False IGHV1 IGKV1 Kappa 9.100000000000001e-11 -13.698318432538965 SPR TBD 6s3d C D 0 M protein s0_2.126 ANTIVIRAL PROTEIN 06/25/19 Structure of D25 Fab in complex with scaffold S0_2.126 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Cramer, J.T., Krey, T. 3.0 X-RAY DIFFRACTION 0.292 0.269 False True IGHV1 IGKV1 Kappa None None None None None 7m2j A B 0 C protein NA ph-gated potassium channel kcsa TRANSPORT PROTEIN/IMMUNE SYSTEM 03/16/21 Structural Snapshots of Intermediates in the Gating of a K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Reddi, R., Valiyaveetil, F.I. 3.201 X-RAY DIFFRACTION 0.305 0.247 False True IGHV1 IGKV5 Kappa None None None None None 7wlz P O 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 01/14/22 Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down-, 1 up- and 1 invisible RBDs) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, Y. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7czs I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B8_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5ivz B A 0 IMMUNE SYSTEM 03/21/16 Cetuximab Fab in complex with Arg8Cir meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.230 0.176 False True IGHV2 IGKV5 Kappa None None None None None 7e3l H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/09/21 Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Li, T., Liu, F., Gao, Y., Ji, X., Yang, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1jp5 a A 0 C peptide epitope peptide corresponding to n-terminus ofhiv-1 protease IMMUNE SYSTEM 08/01/01 Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-1 protease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus Rezacova, P., Lescar, J., Brynda, J., Fabry, M., Horejsi, M., Sedlacek, J., Bentley, G.A. 2.7 X-RAY DIFFRACTION 0.287 0.229 True True unknown unknown unknown None None None None None 6mek F E 0 C protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HEPACIVIRUS C; HOMO SAPIENS homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.290 0.223 False True IGHV1 IGLV1 Lambda None None None None None 3mob H L 0 P peptide gp41 mper-derived peptide IMMUNE SYSTEM 04/22/10 Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced Fab) with 11 aa gp41 MPER-derived peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 2.6 X-RAY DIFFRACTION 0.236 0.190 False True IGHV2 IGKV1 Kappa None None None None None 6gc2 H L 0 IMMUNE SYSTEM 04/17/18 AbLIFT: Antibody stability and affinity optimization by computational design of the variable light-heavy chain interface HOMO SAPIENS homo sapiens homo sapiens Warszawski, S., Katz, A., Khmelnitsky, L., Ben Nissan, G., Javitt, G., Dym, O., Unger, T., Knop, O., Diskin, R., Albeck, S., Fass, D., Sharon, M., Fleishman, S.J. 2.55 X-RAY DIFFRACTION 0.261 0.193 False True IGHV1 IGKV5 Kappa None None None None None 6muf D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/23/18 Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.4 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.91 X-RAY DIFFRACTION 0.297 0.253 False True unknown unknown unknown None None None None None 1bgx H L 0 T protein taq dna polymerase COMPLEX (POLYMERASE/INHIBITOR) 06/02/98 TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB THERMUS AQUATICUS; MUS MUSCULUS mus musculus mus musculus thermus aquaticus Murali, R., Sharkey, D.J., Daiss, J.L., Krishna Murthy, H.M. 2.3 X-RAY DIFFRACTION 0.253 0.189 False True IGHV3 IGKV4 Kappa None None None None None 5lxa H h 0 A protein adiponectin receptor protein 2 MEMBRANE PROTEIN 09/20/16 CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID AT 3.0 ANGSTROM RESOLUTION MUS MUSCULUS; HOMO SAPIENS mus musculus homo sapiens Vasiliauskaite-Brooks, I., Leyrat, C., Hoh, F., Granier, S. 3.0 X-RAY DIFFRACTION 0.254 0.199 True True unknown unknown unknown None None None None None 5udc B C 0 A protein fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F A2 Bound to MEDI8897 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2) homo sapiens homo sapiens human respiratory syncytial virus a (straina2) McLellan, J.S. 3.45 X-RAY DIFFRACTION 0.232 0.175 False True IGHV1 IGKV1 Kappa None None None None None 4pir F NA 0 E protein 5-hydroxytryptamine receptor 3a TRANSPORT PROTEIN 05/09/14 X-ray structure of the mouse serotonin 5-HT3 receptor MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M.B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X.-D., Poitevin, F., Vogel, H., Nury, H. 3.5 X-RAY DIFFRACTION 0.257 0.217 False True IGHV1 None None None None None 3chn A L 4 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 4glr J K 0 B peptide NA phospho-peptide IMMUNE SYSTEM 08/14/12 Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235 GALLUS GALLUS; SYNTHETIC CONSTRUCT gallus gallus gallus gallus homo sapiens Tu, C., Mosyak, L., Bard, J. 1.9 X-RAY DIFFRACTION 0.208 0.179 False True unknown unknown unknown None None None None None 4leo A B 0 C protein receptor tyrosine-protein kinase erbb-3 Transferase/Immune System 06/26/13 Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Schiller C.B., Hopfner K.P. 2.64 X-RAY DIFFRACTION 0.258 0.228 False True IGHV1 IGKV4 Kappa 5e-10 -12.68887519701207 SPR TBD 6vy5 H L 0 A protein NA receptor binding protein VIRAL PROTEIN/IMMUNE SYSTEM 02/25/20 Crystal structure of Nipah receptor binding protein head domain in complex with human neutralizing antibody HENV-26 HOMO SAPIENS; NIPAH HENIPAVIRUS homo sapiens homo sapiens nipah henipavirus Dong, J., Crowe, J.E. 3.4 X-RAY DIFFRACTION 0.250 0.208 False True IGHV3 IGLV3 Lambda None None None None None 7nd4 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-88 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 1w72 I M 0 D | F protein | peptide NA | NA hla class i histocompatibility antigen | melanoma-associated antigen 1 IMMUNE SYSTEM 08/27/04 Crystal structure of HLA-A1:MAGE-A1 in complex with Fab-Hyb3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Hulsmeyer, M., Chames, P., Hillig, R.C., Stanfield, R.L., Held, G., Coulie, P.G., Alings, C., Wille, G., Saenger, W., Ziegler, B.Uchanska-, Hoogenboom, H.R., Zieger, A. 2.15 X-RAY DIFFRACTION 0.248 0.182 False True IGHV3 IGLV3 Lambda 1.40e-08 -10.71 SPR 15537658 5fgc E B 0 A peptide genome polyprotein VIRAL PROTEIN 12/20/15 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.8 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus genotype 1a (isolate h) Girard-Blanc, C., Rey, F.A., Krey, T. 1.9 X-RAY DIFFRACTION 0.236 0.194 False True IGHV3 IGLV3 Lambda None None None None None 6b3s C D 0 B protein epidermal growth factor receptor TRANSFERASE/immune system 09/23/17 Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Bagchi, A. 2.8 X-RAY DIFFRACTION 0.245 0.208 False True IGHV4 IGKV3 Kappa 1.2000000000000002e-08 -10.805930168369423 SPR TBD 2oqj B A 0 C peptide peptide 2g12.1 (acppshvldmrsgtclaaegk) Immune system 01/31/07 Crystal structure analysis of Fab 2G12 in complex with peptide 2G12.1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Menendez, A., Scott, J.K., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.275 0.234 False False IGHV3 IGKV1 Kappa 2.00e-04 -5.04 SPR 25 18198210 4q6i B A 0 K protein t-cell surface glycoprotein cd4 IMMUNE SYSTEM 04/22/14 Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Boyington, J.C., Nabel, G.J., Mascola, J.R. 3.65 X-RAY DIFFRACTION 0.257 0.226 False False IGHV9 IGKV3 Kappa None None None None None 4j1u D C 0 IMMUNE SYSTEM 02/02/13 Crystal structure of antibody 93F3 unstable variant MUS MUSCULUS mus musculus mus musculus Wang, F. 2.58 X-RAY DIFFRACTION 0.276 0.210 False True IGHV2 IGKV8 Kappa None None None None None 6svl H L 0 Q protein myeloid-derived growth factor CYTOKINE 09/18/19 human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ebenhoch, R., Nar, H. 1.58 X-RAY DIFFRACTION 0.206 0.181 False True IGHV14 IGKV12 Kappa None None None None None 6z3x B NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/20 Crystal structure of the designed antibody DesAb-anti-HSA-P1 SYNTHETIC CONSTRUCT synthetic construct Costanzi, E., Sormanni, P., Ricagno, S. 1.74 X-RAY DIFFRACTION 0.220 0.193 False True IGHV3 NA NA None None None None None 1mak NA A 1 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6a0z H L 0 A protein hemagglutinin,envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/06/18 Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA head region INFLUENZA A VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus influenza a virus, human immunodeficiency virus1 Li, S., Li, T. 2.329 X-RAY DIFFRACTION 0.218 0.172 False False IGHV1 IGKV6 Kappa 5.3000000000000005e-08 -9.925863641076687 SPR TBD 4jzn C D 0 immune system/viral protein 04/03/13 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Krey, T., Rey, F.A. 2.05 X-RAY DIFFRACTION 0.235 0.198 False True IGHV1 IGLV3 Lambda None None None None None 4hkb E F 0 IMMUNE SYSTEM 10/15/12 CH67 Fab (unbound) from the CH65-67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 3.6 X-RAY DIFFRACTION 0.306 0.258 False True IGHV1 IGLV3 Lambda None None None None None 6nou A a 0 IMMUNE SYSTEM 01/16/19 An scFv derived from ixekizumab HOMO SAPIENS homo sapiens Durbin, J.D., Clawson, D.K., Lu, F., Tian, Y., Lu, J., Atwell, S. 1.914 X-RAY DIFFRACTION 0.234 0.180 True True unknown unknown unknown None None None None None 5i8e C D 0 IMMUNE SYSTEM 02/18/16 Crystal Structure of Broadly Neutralizing HIV-1 Fusion Peptide-Targeting Antibody VRC34.01 Fab HOMO SAPIENS homo sapiens homo sapiens Xu, K., Zhou, T., Liu, K., Kwong, P.D. 2.655 X-RAY DIFFRACTION 0.248 0.186 False True IGHV1 IGKV1 Kappa None None None None None 6au5 D C 0 IMMUNE SYSTEM 08/30/17 Structure of cetuximab with aminoheptanoic acid-linked n-butylarginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.484 X-RAY DIFFRACTION 0.227 0.186 False True IGHV2 IGKV5 Kappa 2.7e-06 -7.5969790708218685 Unknown TBD 6e63 H L 0 P protein pf48/45 IMMUNE SYSTEM 07/23/18 Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody TB31F PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Kundu, P., Semesi, A., Julien, J.P. 2.6 X-RAY DIFFRACTION 0.240 0.202 False True IGHV3 IGLV6 Lambda 3.7000000000000005e-09 -11.503030961041175 SPR TBD 6chb J K 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 6.801 X-RAY DIFFRACTION 0.417 0.318 False True unknown IGLV3 Lambda None None None None None 3ve0 A B 0 J | J | I carbohydrate | protein | protein NAG | NA | NA N-ACETYL-D-GLUCOSAMINE | envelope glycoprotein | envelope glycoprotein Immune system/viral protein 01/06/12 Crystal structure of Sudan Ebolavirus Glycoprotein (strain Boniface) bound to 16F6 SUDAN EBOLAVIRUS; MUS MUSCULUS mus musculus mus musculus sudan ebolavirus | sudan ebolavirus | sudan ebolavirus Saphire, E.O., Bale, S., Dias, J.M. 3.353 X-RAY DIFFRACTION 0.289 0.222 False False IGHV5 IGKV6 Kappa 1.94e-06 -7.7928327274821685 SPR TBD 4pgj A NA 0 B protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/02/14 Human heavy-chain domain antibody in complex with hen egg-white lysozyme HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Christ, D., Langley, D.B., Rouet, R. 2.6 X-RAY DIFFRACTION 0.287 0.225 False True IGHV3 2.6e-08 -10.347827778050062 SPR TBD 7r89 C D 0 B | A protein | protein NA | NA atp-binding cassette sub-family g member 8 | atp-binding cassette sub-family g member 5 LIPID TRANSPORT 06/26/21 The structure of human ABCG5/ABCG8 purified from yeast HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Sun, Y., Li, X., Long, T. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV9 Kappa None None None None None 7v0v A NA 5 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 5drn A B 0 IMMUNE SYSTEM 01/20/16 Context-independent anti-hypusine antibody FabHpu24 in complex with hypusine ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Zhai, Q., Carter, P.J. 1.994 X-RAY DIFFRACTION 0.222 0.183 False True IGHV1 IGKV1 Kappa None None None None None 6vcb N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/MEMBRANE PROTEIN 12/20/19 Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Sun, B., Feng, D., Bueno, A., Kobilka, B., Sloop, K. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4wv1 B A 0 C protein fibroblast growth factor receptor 2 TRANSFERASE/IMMUNE SYSTEM 11/04/14 Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, Y., Carter, P.J. 2.362 X-RAY DIFFRACTION 0.244 0.198 False True IGHV3 IGKV1 Kappa 2.6e-09 -11.712071867460315 SPR TBD 4d9l H L 0 IMMUNE SYSTEM 01/11/12 Fab structure of anti-HIV-1 gp120 V2 mAb 697 HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.485 X-RAY DIFFRACTION 0.238 0.176 False True IGHV1 IGLV1 Lambda None None None None None 5tlj D C 0 X protein cd27 antigen IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 3.5 X-RAY DIFFRACTION 0.356 0.283 False True IGHV5 IGKV3 Kappa None None None None None 5ibt H L 0 IMMUNE SYSTEM 02/22/16 UCA Fab (unbound) from 6515 Lineage HOMO SAPIENS homo sapiens homo sapiens Raymond, D.D., Harrison, S.C. 2.4 X-RAY DIFFRACTION 0.278 0.205 False True IGHV5 IGKV3 Kappa None None None None None 3chn A L 7 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 6cuf m n 0 d protein unknown VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False False IGHV4 IGLV3 Lambda None None None None None 6xxn E NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 5wi9 H L 0 A protein beta-klotho STRUCTURAL PROTEIN 07/18/17 Crystal structure of KL with an agonist Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Johnstone, S., Min, X., Wang, Z. 2.7 X-RAY DIFFRACTION 0.270 0.216 False True IGHV3 IGKV3 Kappa 8.6e-11 -13.731800994840723 SPR TBD 3r0m B NA 0 Immune system 03/08/11 Crystal structure of anti-HIV llama VHH antibody A12 LAMA GLAMA lama glama Chen, L., McLellan, J.S., Kwon, Y.D., Schmidt, S., Wu, X., Zhou, T., Yang, Y., Zhang, B., Forsman, A., Weiss, R.A., Verrips, T., Mascola, J., Kwong, P.D. 1.5 X-RAY DIFFRACTION 0.217 0.193 False True IGHV1 None None None None None 3qxt B NA 0 B Hapten MTX METHOTREXATE IMMUNE SYSTEM 03/02/11 Structure of an Anti-Methotrexate CDR1-3 Graft VHH Antibody in Complex with Methotrexate LAMA GLAMA lama glama lama glama Fanning, S.W., Horn, J.R. 1.7 X-RAY DIFFRACTION 0.195 0.175 False True IGHV1 6e-06 -7.123876292458442 Unknown TBD 6b6z B A 0 IMMUNE SYSTEM 12/19/18 Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains) HOMO SAPIENS homo sapiens homo sapiens Radwanska, M.J., Derewenda, U., Kossiakoff, A.A., Derewenda, Z.S. 2.112 X-RAY DIFFRACTION 0.258 0.203 False True IGHV3 IGKV1 Kappa None None None None None 2qtj C O 5 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6x1u H L 0 D peptide NA aclyana-3-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC39-4) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R., Wilson, I.A., Hunter, T. 1.641 X-RAY DIFFRACTION 0.225 0.189 False True IGHV1 IGKV1 Kappa None None None None None 4kvc H L 0 IMMUNE SYSTEM 05/22/13 2H2 Fab fragment of immature Dengue virus MUS MUSCULUS mus musculus mus musculus Wang, Z., Rossmann, M.G. 2.306 X-RAY DIFFRACTION 0.234 0.179 False True IGHV5 IGKV6 Kappa None None None None None 2kh2 B b 65 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7seg H L 0 C protein NA low affinity immunoglobulin gamma fc region receptor iii-a ANTITUMOR PROTEIN 09/30/21 Crystal structure of the complex of CD16A bound by an anti-CD16A Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kiefer, J.R., Wallweber, H.A., Polson, A.G. 2.156 X-RAY DIFFRACTION 0.234 0.189 False True IGHV1 IGLV3 Lambda None None None None None 7jmp H L 0 A protein NA spike protein s1 Viral Protein/IMMUNE SYSTEM 08/02/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-39 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wu, N.C., Yuan, M., Liu, H., Zhu, X., Wilson, I.A. 1.712 X-RAY DIFFRACTION 0.209 0.177 False True IGHV3 IGLV2 Lambda None None None None None 7p5y J NA 0 D protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6dyx D NA 0 IMMUNE SYSTEM 07/02/18 Structure of VHH R419 isolated from a pre-immune phage display library VICUGNA PACOS vicugna pacos Brooks, C.L. 1.5 X-RAY DIFFRACTION 0.190 0.176 False True IGHV1 None None None None None 7rk2 C c 0 B protein NA capsid protein vp25 VIRAL PROTEIN 07/21/21 Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 2D9, an astrovirus-neutralizing antibody, at 2.65-A resolution HUMAN ASTROVIRUS-8; MUS MUSCULUS mus musculus human astrovirus-8 Meyer, L., Cuellar, C., DuBois, R.M. 2.65 X-RAY DIFFRACTION 0.247 0.218 True True unknown unknown unknown None None None None None 4ma1 E F 0 IMMUNE SYSTEM 08/15/13 Unliganded 3 crystal structure of S25-26 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.32 X-RAY DIFFRACTION 0.260 0.229 False False IGHV2 IGKV1 Kappa None None None None None 4s1d O P 0 P Hapten 41M N~6~-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}-L-lysinamide IMMUNE SYSTEM 01/13/15 Structure of IgG1 Fab fragment in complex with Biotincytidinamide MUS MUSCULUS mus musculus mus musculus mus musculus Dengl, S., Hoffmann, E., Grote, M., Wagner, C., Mundigl, O., Georges, G., Theorey, I., Stubenrauch, K.-G., Bujotzek, A., Josel, H.-P., Dziadek, S., Benz, J., Brinkmann, U. 2.5 X-RAY DIFFRACTION 0.274 0.225 False True IGHV14 IGKV12 Kappa None None None None None 3cm9 B M 1 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 1fbi H L 0 X protein guinea fowl lysozyme COMPLEX (ANTIBODY/ANTIGEN) 01/19/95 CRYSTAL STRUCTURE OF A CROSS-REACTION COMPLEX BETWEEN FAB F9.13.7 AND GUINEA-FOWL LYSOZYME MUS MUSCULUS; NUMIDA MELEAGRIS mus musculus mus musculus numida meleagris Lescar, J., Alzari, P.M. 3.0 X-RAY DIFFRACTION unknown 0.190 False True IGHV1 IGKV10 Kappa None None None None None 7mw2 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with all RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3cm9 C N 2 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 2v7n B A 0 IMMUNE SYSTEM 07/31/07 Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4 SYNTHETIC CONSTRUCT synthetic construct synthetic construct Frey, D., Huber, T., Plueckthun, A., Gruetter, M.G. 1.92 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 1c08 B A 0 C protein lysozyme IMMUNE SYSTEM/HYDROLASE 07/15/99 CRYSTAL STRUCTURE OF HYHEL-10 FV-HEN LYSOZYME COMPLEX MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Matsushima, M., Tsumoto, K., Kumagai, I. 2.3 X-RAY DIFFRACTION 0.175 0.235 False True IGHV3 IGKV5 Kappa None None None None None 6ffj E e 0 ANTITUMOR PROTEIN 01/08/18 Anti-tumor antibody 14F7-derived single chain fragment variable (scFv) HOMO SAPIENS homo sapiens Bjerregaard-Andersen, K., Heggelund, J.E., Krengel, U. 2.2 X-RAY DIFFRACTION 0.238 0.184 True True unknown unknown unknown None None None None None 6flb H L 0 G protein domain iii of dengue virus 2 VIRAL PROTEIN 01/25/18 3H5 Fab bound to EDIII of DenV 2 Xtal form 2 DENGUE VIRUS 2; MUS MUSCULUS mus musculus mus musculus dengue virus 2 Flanagan, A., Renner, M., Grimes, J.M. 2.2 X-RAY DIFFRACTION 0.218 0.176 False True IGHV1 IGKV3 Kappa 1e-09 -12.27819680469229 SPR TBD 6a4k I M 0 B protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/20/18 Human antibody 32D6 Fab in complex with H1N1 influenza A virus HA1 INFLUENZA A VIRUS (A/CALIFORNIA/7/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/7/2009(h1n1)) Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 3.15 X-RAY DIFFRACTION 0.233 0.175 False True IGHV4 IGLV4 Lambda None None None None None 5cey B A 0 IMMUNE SYSTEM 07/07/15 Crystal Structure of Fab 9H+3L, a putative precursor of the PGT121 family of potent HIV-1 antibodies HOMO SAPIENS homo sapiens homo sapiens Wilson, I.A., Garces, F. 2.387 X-RAY DIFFRACTION 0.273 0.224 False True IGHV4 unknown unknown None None None None None 6iyn A NA 9 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 5t93 NA A 0 IMMUNE SYSTEM 09/09/16 Immunoglobulin light chain variable domain AL-T05 HOMO SAPIENS homo sapiens Ramirez-Alvarado, M., Blancas-Mejia, L.M. 1.9 X-RAY DIFFRACTION 0.223 0.171 False True IGLV1 Lambda None None None None None 6qf6 B b 0 APOPTOSIS 01/09/19 Structure of an E.coli expressed anti-Mcl1 scFv HOMO SAPIENS homo sapiens Luptak, J. 2.59 X-RAY DIFFRACTION 0.262 0.181 True True unknown unknown unknown None None None None None 6h70 C NA 0 B protein NA capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-62 and 2-fucosyllactose (2FL) NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 1.83 X-RAY DIFFRACTION 0.191 0.162 False True IGHV1 NA NA None None None None None 5nlw A NA 0 IMMUNE SYSTEM 04/05/17 Structure of Nb36 crystal form 2 LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 1.5 X-RAY DIFFRACTION 0.248 0.199 False True IGHV1 None None None None None 6umi H L 0 IMMUNE SYSTEM 10/09/19 Crystal structure of erenumab Fab-b HOMO SAPIENS homo sapiens homo sapiens Mohr, C. 2.4 X-RAY DIFFRACTION 0.220 0.184 False True IGHV3 IGLV1 Lambda None None None None None 5wna C D 0 A peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 07/31/17 Structure of antibody 3D3 bound to the central conserved region of RSV G HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A homo sapiens homo sapiens human respiratory syncytial virus a Fedechkin, S.O., George, N.L., Wolff, J.T., Kauvar, L.M., DuBois, R.M. 2.4 X-RAY DIFFRACTION 0.246 0.192 False True IGHV3 IGKV3 Kappa None None None None None 7v0v A NA 12 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6nov C D 0 IMMUNE SYSTEM 01/16/19 A Fab derived from ixekizumab HOMO SAPIENS homo sapiens homo sapiens Durbin, J.D., Clawson, D.K., Lu, F., Tian, Y., Lu, J., Schmitt, M., Atwell, S. 2.14 X-RAY DIFFRACTION 0.278 0.238 False True IGHV1 IGKV2 Kappa None None None None None 6vn0 I K 0 F | D protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 01/29/20 BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Shin, M., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 7pi2 E F 0 D protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to monoclonal antibody Cy.003 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 3.14 X-RAY DIFFRACTION 0.239 0.219 False True unknown unknown unknown None None None None None 7tus G H 0 NA NA NA NA IMMUNE SYSTEM 02/03/22 Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation HOMO SAPIENS homo sapiens homo sapiens Park, H., Rader, C. 2.4 X-RAY DIFFRACTION 0.257 0.218 False True IGHV6 IGKV1 Kappa None None None None None 5w9j B C 0 A protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7r74 B NA 0 C protein NA glycoprotein 120 IMMUNE SYSTEM 06/24/21 Crystal structure of llama VHH antibody in complex with HIV-1 HXBC2 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.76 X-RAY DIFFRACTION 0.270 0.212 False True IGHV1 NA NA None None None None None 1igf J M 0 IMMUNOGLOBULIN 03/21/91 CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.180 False True IGHV5 IGKV1 Kappa None None None None None 6w0d A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Open-gate KcsA soaked in 5 mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 3.639 X-RAY DIFFRACTION 0.248 0.190 False True IGHV1 IGKV5 Kappa None None None None None 6cwg D NA 0 C protein ricin IMMUNE SYSTEM 03/30/18 Ricin catalytic subunit bound go A9 VHH antibody RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Mantis, N. 2.6 X-RAY DIFFRACTION 0.262 0.223 False True IGHV1 None None None None None 6pxr H L 0 A peptide NA microtubule-associated protein tau IMMUNE SYSTEM 07/26/19 Anti-TAU BIIB092 FAB with TAU peptide MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Arndt, J.W., Quan, C. 1.556 X-RAY DIFFRACTION 0.268 0.228 False True IGHV5 IGKV1 Kappa None None None None None 7k8w H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C119 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Sharaf, N.G., Barnes, C.O., Bjorkman, P.J. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6wgk A B 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.62 X-RAY DIFFRACTION 0.236 0.210 False True IGHV3 IGKV2 Kappa None None None None None 6z43 Y NA 0 B protein spike glycoprotein VIRAL PROTEIN 06/03/20 Cryo-EM Structure of SARS-CoV-2 Spike : H11-D4 Nanobody Complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Ruza, R.R., Duyvesteyn, H.M.E., Shah, P., Carrique, L., Ren, J., Malinauskas, T., Zhou, D., Stuart, D.I., Naismith, J.H. 3.3 ELECTRON MICROSCOPY False True IGHV1 None None None None None 4utb I M 0 B protein envelope glycoprotein e IMMUNE SYSTEM/VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Rouvinski, A., Guardado-Calvo, P., Barba-Spaeth, G., Duquerroy, S., Vaney, M.C., Rey, F.A. 3.85 X-RAY DIFFRACTION 0.2567 0.2297 False True IGHV3 IGLV2 Lambda None None None None None 7cwl H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 SARS-CoV-2 spike protein and P17 fab complex with one RBD in close state SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1hq4 B A 0 immune system 12/14/00 STRUCTURE OF NATIVE CATALYTIC ANTIBODY HA5-19A4 MUS MUSCULUS mus musculus mus musculus Paschall, C.M., Hasserodt, J., Lerner, R.A., Janda, K.D., Christianson, D.W. 2.7 X-RAY DIFFRACTION 0.265 0.225 False False IGHV3 IGKV4 Kappa None None None None None 1qbl H L 0 IMMUNOGLOBULIN 04/29/98 FAB E8 (FABE8A) X-RAY STRUCTURE AT 2.26 ANGSTROM RESOLUTION MUS MUSCULUS mus musculus mus musculus Mylvaganam, S.E., Paterson, Y., Getzoff, E.D. 2.26 X-RAY DIFFRACTION 0.277 0.192 False False IGHV14 IGKV12 Kappa None None None None None 6qkd NA O 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGKV3 Kappa None None None None None 1jtp B NA 0 M protein NA lysozyme c Antibody, Hydrolase 08/21/01 Degenerate interfaces in antigen-antibody complexes CAMELUS DROMEDARIUS; MELEAGRIS GALLOPAVO camelus dromedarius meleagris gallopavo Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L. 1.9 X-RAY DIFFRACTION 0.229 0.184 False True IGHV1 NA NA None None None None None 5chn A B 0 IMMUNE SYSTEM 07/10/15 Fab fragments of chikungunya virus neutralizing human monoclonal antibody 5M16 HOMO SAPIENS homo sapiens homo sapiens Long, F., Crowe, J.E., Rossmann, M.G. 2.047 X-RAY DIFFRACTION 0.218 0.172 False False IGHV1 IGKV2 Kappa None None None None None 6oz3 H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 05/15/19 Crystal structure of broadly neutralizing antibody N49P9.1 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 3.15 X-RAY DIFFRACTION 0.295 0.243 False True unknown unknown unknown None None None None None 5fxc H h 0 P peptide glycopeptide 02/29/16 Crystal structure of glycopeptide 22 in complex with scFv-SM3 MUS MUSCULUS mus musculus mus musculus Rojas-Ocariz, V., Companon, I., Aydillo, C., Castro- Lopez, J., Jimenez-Barbero, J., Hurtado-Guerrero, R., Avenoza, A., Zurbano, M.M., Corzana, F., Busto, J.H., Peregrina, J.M. 2.05 X-RAY DIFFRACTION 0.27672 0.19979 True True unknown unknown unknown None None None None None 5sv4 B NA 0 TOXIN 08/04/16 Anti-Ricin A-chain Single Domain Antibody A3C8 LAMA GLAMA lama glama Compton, J.R., Legler, P.M. 2.7 X-RAY DIFFRACTION 0.246 0.198 False True IGHV1 None None None None None 5ggr H L 0 Z protein programmed cell death protein 1 IMMUNE SYSTEM 06/16/16 PD-1 in complex with nivolumab Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heo, Y.S. 3.3 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGKV3 Kappa None None None None None 7k90 M N 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C144 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Esswein, S.R., Bjorkman, P.J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 2vyr E NA 0 A protein mdm4 protein IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 7e5s P N 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 4fqq B A 0 IMMUNE SYSTEM 06/25/12 Crystal Structure of Germline Antibody PGT121-GL Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 2.42 X-RAY DIFFRACTION 0.237 0.194 False True IGHV4 IGLV3 Lambda None None None None None 7mzh B C 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 119 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Tan, L.L., Dietrich, M.H., Chan, L.J., Tham, W.H. 2.1 X-RAY DIFFRACTION 0.265 0.220 False True IGHV1 IGLV1 Lambda None None None None None 7sht H L 0 B protein NA immunoglobulin heavy constant epsilon IMMUNE SYSTEM 10/11/21 Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.S. 7.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5xhg B A 0 IMMUNE SYSTEM 04/20/17 Crystal structure of Trastuzumab Fab fragment bearing Ne-(o-azidobenzyloxycarbonyl)-L-lysine ESCHERICHIA COLI STR. K-12 SUBSTR. W3110 escherichia coli str. k-12 substr. w3110 escherichia coli str. k-12 substr. w3110 Kuratani, M., Yanagisawa, T., Sakamoto, K., Yokoyama, S. 1.76 X-RAY DIFFRACTION 0.199 0.173 False True IGHV3 IGKV1 Kappa None None None None None 4ut7 H L 0 IMMUNE SYSTEM 07/18/14 CRYSTAL STRUCTURE OF THE SCFV FRAGMENT OF THE BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 HOMO SAPIENS homo sapiens homo sapiens ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 1.7 X-RAY DIFFRACTION 0.1909 0.1602 False True IGHV3 IGLV2 Lambda None None None None None 5h35 H I 0 D protein membrane protein tric IMMUNE SYSTEM/MEMBRANE PROTEIN 10/20/16 Crystal structures of the TRIC trimeric intracellular cation channel orthologue from Sulfolobus solfataricus SULFOLOBUS SOLFATARICUS; MUS MUSCULUS mus musculus mus musculus sulfolobus solfataricus Kasuya, G., Hiraizumi, M., Hattori, M., Nureki, O. 2.642 X-RAY DIFFRACTION 0.252 0.211 False True IGHV5 IGKV1 Kappa None None None None None 1nl0 H L 0 G peptide factor ix IMMUNE SYSTEM 01/06/03 Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Huang, M., Furie, B.C., Furie, B. 2.2 X-RAY DIFFRACTION 0.270 0.233 False True IGHV3 IGLV1 Lambda 1.6000000000000003e-09 -11.99972732482342 Unknown TBD 7pqq B NA 0 A protein NA sodium/bile acid cotransporter MEMBRANE PROTEIN 09/18/21 Structure of thermostabilised human NTCP in complex with Megabody 91 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Goutam, K., Reyes, N. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4jdv A B 0 IMMUNE SYSTEM 02/25/13 Crystal structure of germ-line precursor of NIH45-46 Fab HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Scharf, L., Bjorkman, P.J. 1.65 X-RAY DIFFRACTION 0.203 0.174 False True IGHV1 IGKV3 Kappa None None None None None 3ezj H NA 0 G protein general secretion pathway protein gspd PROTEIN TRANSPORT 10/22/08 Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Korotkov, K.V, Pardon, E., Steyaert, J., Hol, W.G. 2.8 X-RAY DIFFRACTION 0.239 0.192 False True IGHV1 None None None None None 4zd3 H L 0 IMMUNE SYSTEM 04/16/15 Structure of a transglutaminase 2-specific autoantibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Dalhus, B., Hnida, K., Iversen, R., Sollid, L.M. 2.4 X-RAY DIFFRACTION 0.264 0.200 False True IGHV5 IGKV1 Kappa None None None None None 7f5h D NA 0 B protein NA sars-cov-2 spike receptor-binding domain (rbd) VIRAL PROTEIN 06/22/21 The crystal structure of RBD-Nanobody complex, DL28 (SC4) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Luo, Z.P., Li, T., Lai, Y., Zhou, Y., Tan, J., Li, D. 3 X-RAY DIFFRACTION 0.248 0.226 False True IGHV1 NA NA None None None None None 1a3r H L 0 P peptide human rhinovirus capsid protein vp2 VIRAL PROTEIN/IMMUNE SYSTEM 01/23/98 FAB FRAGMENT (ANTIBODY 8F5) COMPLEXED WITH PEPTIDE FROM HUMAN RHINOVIRUS (SEROTYPE 2) VIRAL CAPSID PROTEIN VP2 (RESIDUES 156-170) MUS MUSCULUS; HUMAN RHINOVIRUS 2 mus musculus mus musculus human rhinovirus 2 Tormo, J., Blaas, D., Fita, I. 2.1 X-RAY DIFFRACTION unknown 0.171 False False IGHV14 IGKV8 Kappa None None None None None 5vk2 D E 0 c | C protein | protein NA | NA unknown | pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/Immune system 04/20/17 Structural basis for antibody-mediated neutralization of Lassa virus LASSA VIRUS; LASSA VIRUS (STRAIN MOUSE/SIERRA LEONE/JOSIAH/1976); HOMO SAPIENS homo sapiens homo sapiens lassa virus (strain mouse/sierraleone/josiah/1976) | lassa virus Hastie, K.M., Zandonatti, M.A., Kleinfelter, L.M., Rowland, M.L., Rowland, M.M., Chandra, K., Branco, L.M., Robinson, J.E., Garry, R.F., Saphire, E.O. 3.201 X-RAY DIFFRACTION 0.231 0.189 False True IGHV3 IGLV2 Lambda None None None None None 4xt1 C NA 0 A protein g-protein coupled receptor homolog us28 VIRAL PROTEIN/SIGNALLING PROTEIN 01/22/15 Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1 CYTOMEGALOVIRUS; HOMO SAPIENS; VICUGNA PACOS vicugna pacos cytomegalovirus Burg, J.S., Jude, K.M., Waghray, D., Garcia, K.C. 2.886 X-RAY DIFFRACTION 0.249 0.199 False True IGHV1 None None None None None 7spa B NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus Hyaluronan Synthase in the GlcNAc-primed, channel-open state LAMA GLAMA; PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3g9a B NA 0 A protein green fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 02/13/09 Green fluorescent protein bound to minimizer nanobody AEQUOREA VICTORIA; CAMELUS DROMEDARIUS lama pacos aequorea victoria Kirchhofer, A., Helma, J., Schmidthals, K., Frauer, C., Cui, S., Karcher, A., Pellis, M., Muyldermans, S., Delucci, C.C., Cardoso, M.C., Leonhardt, H., Hopfner, K.-P., Rothbauer, U. 1.614 X-RAY DIFFRACTION 0.194 0.161 False True IGHV1 None None None None None 6xpy B C 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 07/09/20 Human antibody S1V2-58 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus McCarthy, K.R., Harrison, S.C. 3.603 X-RAY DIFFRACTION 0.304 0.256 False True IGHV4 IGKV1 Kappa None None None None None 1fgv H L 0 IMMUNOGLOBULIN 11/01/93 X-RAY STRUCTURES OF FRAGMENTS FROM BINDING AND NONBINDING VERSIONS OF A HUMANIZED ANTI-CD18 ANTIBODY: STRUCTURAL INDICATIONS OF THE KEY ROLE OF VH RESIDUES 59 TO 65 HOMO SAPIENS Eigenbrot, C., Kessler, J. 1.9 X-RAY DIFFRACTION unknown 0.180 False True IGHV3 IGKV1 Kappa None None None None None 3lhp H L 0 S protein 4e10_d0_1isea_004_n (t93) IMMUNE SYSTEM 01/22/10 Crystal structure of HIV epitope-scaffold 4E10_D0_1ISEA_004_N 4E10 Fv complex HOMO SAPIENS; ARTIFICIAL GENE homo sapiens homo sapiens artificial gene Holmes, M.A. 2.7 X-RAY DIFFRACTION 0.335 0.243 False True IGHV1 IGKV3 Kappa 7.50e-12 -15.17 SPR 20826338 6uym H L 0 E protein envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v6 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C HEPATITIS C VIRUS (ISOLATE H); HOMO SAPIENS homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Zhu, J. 2.848 X-RAY DIFFRACTION 0.260 0.215 False True IGHV1 IGKV3 Kappa None None None None None 3iu4 H L 0 IMMUNE SYSTEM 08/29/09 anti NeuGcGM3 ganglioside chimeric antibody chP3 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Eriksson, A., Okvist, M., Talavera, A., Krengel, U. 1.75 X-RAY DIFFRACTION 0.234 0.194 False True IGHV2 IGKV6 Kappa None None None None None 5tjw K NA 0 A protein nucleoprotein Viral Protein/Immune System 10/05/16 Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody VICUGNA PACOS; INFLUENZA A VIRUS (A/WSN/1933(H1N1)) vicugna pacos influenza a virus (a/wsn/1933(h1n1)) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.231 X-RAY DIFFRACTION 0.262 0.204 False True IGHV1 None None None None None 6udj H I 0 J protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 2.5 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 5mub R S 0 T peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 6q1a H L 0 IMMUNE SYSTEM 08/03/19 Inferred intermediate mutant (I-6V) of the human antibody lineage 652 HOMO SAPIENS homo sapiens homo sapiens McCarthy, K.R., Harrison, S.C. 2.001 X-RAY DIFFRACTION 0.225 0.203 False True IGHV4 IGLV3 Lambda None None None None None 4fnl I M 0 IMMUNE SYSTEM 06/19/12 Crystal structure of broadly neutralizing antibody C05 HOMO SAPIENS homo sapiens homo sapiens Ekiert, D.C., Wilson, I.A. 2.297 X-RAY DIFFRACTION 0.240 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6m58 C D 0 B protein serum albumin IMMUNE SYSTEM 03/10/20 Crystal structure of a complex between human serum albumin and the antibody Fab SL335 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Cho, S.Y., Yoon, S.I. 2.95 X-RAY DIFFRACTION 0.242 0.193 False True IGHV3 IGKV3 Kappa None None None None None 7e8f C B 0 R protein NA spike protein s1 VIRAL PROTEIN 03/01/21 SARS-CoV-2 NTD in complex with N9 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 6ad7 C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148D mutant CLC-ec1 in 20 mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 2.95 X-RAY DIFFRACTION 0.269 0.223 False False IGHV4 IGKV4 Kappa None None None None None 5yoy Q N 0 L protein tumor necrosis factor IMMUNE SYSTEM 10/31/17 Crystal structure of the human tumor necrosis factor in complex with golimumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N. 2.727 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV3 Kappa 1.8e-11 -14.658430977236662 Unknown TBD 5hd8 C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 01/05/16 Crystal structure of disulfide cross-linked D417C ClC-ec1 ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Mathews, I.I., Khantwal, C.M., Maduke, M. 3.15 X-RAY DIFFRACTION 0.257 0.205 False True IGHV4 IGKV4 Kappa None None None None None 5ocl C NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA vicugna pacos Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 5y2l I J 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin ANTIMICROBIAL PROTEIN 07/26/17 Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the 1968 H3N2 pandemic (H3-AC/68) hemagglutinin INFLUENZA A VIRUS (STRAIN A/AICHI/2/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/aichi/2/1968 h3n2) | influenza a virus (strain a/aichi/2/1968 h3n2) Xiao, H., Qi, J., Gao, F.G. 2.902 X-RAY DIFFRACTION 0.244 0.212 False True IGHV3 IGKV3 Kappa None None None None None 7kr5 O P 0 F | E protein | protein NA | NA calcium release-activated calcium channel protein 1 | calcium release-activated calcium channel protein 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 11/18/20 Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster | drosophila melanogaster Long, S.B., Hou, X., Outhwaite, I.R. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV6 Kappa None None None None None 6whc N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/27/20 CryoEM Structure of the glucagon receptor with a dual-agonist peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Belousoff, M.J., Sexton, P., Danev, R. 3.4 ELECTRON MICROSCOPY False True IGHV3 None None None None None 3dwt D NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 6ltg A B 0 IMMUNE SYSTEM 06/17/20 Crystal structure of the Fab fragment of murine monoclonal antibody OHV-3 against Human herpesvirus 6B MUS MUSCULUS mus musculus mus musculus Nishimura, M., Novita, B.D., Kato, T., Tjan, L.H., Wang, B., Wakata, A., Poetranto, A.L., Kawabata, A., Tang, H., Aoshi, T., Mori, Y. 1.63 X-RAY DIFFRACTION 0.204 0.182 False False IGHV2 IGKV3 Kappa None None None None None 6ywc D E 0 F protein NA de novo design 4e1h_95 DE NOVO PROTEIN 04/29/20 De novo designed protein 4E1H_95 in complex with 101F antibody HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Yang, C., Sesterhenn, F., Pojer, F., Correia, B.E. 2.85 X-RAY DIFFRACTION 0.248 0.212 False True IGHV8 IGKV3 Kappa None None None None None 6r0x A B 0 E protein megakaryocyte and platelet inhibitory receptor g6b BLOOD CLOTTING 03/13/19 The extracellular domain of G6b-B in complex with Fab fragment and DP12 heparin oligosaccharide. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ogg, D.J., McMiken, H.J., Howard, T.D. 3.13 X-RAY DIFFRACTION 0.266 0.230 False True IGHV14 IGKV10 Kappa None None None None None 6s3t R Q 0 B protein 46 kda surface antigen PROTEIN BINDING 06/26/19 P46, an immunodominant surface protein from Mycoplasma hyopneumoniae MYCOPLASMA HYOPNEUMONIAE J; MUS MUSCULUS mus musculus mus musculus mycoplasma hyopneumoniae j Guasch, A., Fita, I. 3.5 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 5v6l I M 0 Q peptide envelope glycoprotein, v3 region VIRAL PROTEIN/IMMUNE SYSTEM 03/17/17 Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A37 in complex with V3 peptide JR-FL ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R., Kong, X.-P. 2.549 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 IGKV1 Kappa None None None None None 1mhp H L 0 A protein integrin alpha 1, (residues 169-360) IMMUNE SYSTEM 08/20/02 Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Karpusas, M., Taylor, F., Ferrant, J., Weinreb, P., Garber, E. 2.8 X-RAY DIFFRACTION 0.272 0.213 False True IGHV3 IGKV1D Kappa None None None None None 6mxr A B 0 IMMUNE SYSTEM 10/31/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M] HOMO SAPIENS homo sapiens homo sapiens Shi, R. 2.04 X-RAY DIFFRACTION 0.200 0.167 False True IGHV3 IGKV1 Kappa None None None None None 7jkb A NA 0 NA NA NA NA IMMUNE SYSTEM 07/28/20 2xVH Fab HOMO SAPIENS homo sapiens Lord, D.M., Zhou, Y.F. 2.55 X-RAY DIFFRACTION 0.292 0.254 False True IGHV3 NA NA None None None None None 6ran C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB in inward-facing wide conformation THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 4.2 ELECTRON MICROSCOPY False True IGHV1 None None None None None 2kqn NA B 19 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6ias H L 0 IMMUNE SYSTEM 11/27/18 structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4 SYNTHETIC CONSTRUCT synthetic construct synthetic construct Roussel, A., Amigues, B. 1.75 X-RAY DIFFRACTION 0.228 0.195 False True IGHV1 IGKV1 Kappa None None None None None 6vo0 G J 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/29/20 BG505 SOSIP.v5.2 in complex with rabbit Fab 43A2 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Nogal, B., Cottrell, C.A., Ward, A.B. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6tul H L 0 NA NA NA NA PROTEIN BINDING 01/07/20 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021177 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 2.25 X-RAY DIFFRACTION 0.318 0.248 False False IGHV3 IGLV1 Lambda None None None None None 6xkp M N 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/26/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-270 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.72 X-RAY DIFFRACTION 0.269 0.220 False True IGHV3 IGLV2 Lambda None None None None None 6fzq H h 0 P peptide mucin-1 IMMUNE SYSTEM 03/15/18 Crystal structure of scFv-SM3 in complex with compound 3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Bermejo, I.A., Usabiaga, I., Companon, I., Castro-Lopez, J., Insausti, A., Fernandez, J.A., Avenoza, A., Busto, J.H., Jimenez-Barbero, J., Asensio, J.L., Jimenez-Oses, G., Peregrina, J.M., Hurtado-Guerrero, R., Cocinero, E.J., Corzana, F. 1.7 X-RAY DIFFRACTION 0.225 0.175 True True unknown unknown unknown None None None None None 6mhg F R 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 4qt5 H L 0 IMMUNE SYSTEM 07/07/14 Crystal Structure of 3BD10: A Monoclonal Antibody against the TSH Receptor MUS MUSCULUS mus musculus mus musculus Hubbard, P.A., Chen, C.R., McLachlan, S.M., Rapoport, B., Murali, R. 2.5 X-RAY DIFFRACTION 0.279 0.235 False True IGHV1 IGKV1 Kappa None None None None None 4jo1 H L 0 P peptide gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/16/13 Crystal structure of rabbit mAb R56 Fab in complex with V3 crown of HIV-1 JR-FL gp120 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R.M., Kong, X.P. 2.033 X-RAY DIFFRACTION 0.223 0.181 False True IGHV1 IGKV1 Kappa None None None None None 2wzp J NA 0 H protein putative receptor binding protein VIRAL PROTEIN 12/01/09 Structures of Lactococcal Phage p2 Baseplate Shed Light on a Novel Mechanism of Host Attachment and Activation in Siphoviridae LACTOCOCCUS PHAGE P2; LAMA GLAMA lama glama lactococcus phage p2 Sciara, G., Bebeacua, C., Bron, P., Tremblay, D., Ortiz-Lombardia, M., Lichiere, J., van Heel, M., Campanacci, V., Moineau, S., Cambillau, C. 2.6 X-RAY DIFFRACTION 0.2078 0.1789 False True IGHV1 None None None None None 6ss0 I M 0 NA NA NA NA PROTEIN BINDING 09/06/19 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021181 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 1.7 X-RAY DIFFRACTION 0.224 0.189 False False IGHV3 IGLV1 Lambda None None None None None 6pi7 C B 0 A protein tudor and kh domain-containing protein PROTEIN BINDING 06/26/19 Crystal structure of the TDRD2 extended Tudor domain in complex with an antibody fragment and the PIWIL1 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, K., Min, J.R., Structural Genomics Consortium (SGC) 2.8 X-RAY DIFFRACTION 0.206 0.190 False True IGHV3 IGKV1 Kappa None None None None None 7d5u D NA 0 A protein NA beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 09/28/20 BACE2 xaperone complex with N-{3-[(9S)-7-amino-2,2-difluoro-9-(prop-1-yn-1-yl)-6-oxa-8-azaspiro[3.5]non-7-en-9-yl]-4-fluorophenyl}-5-cyanopyridine-2-carboxamide HOMO SAPIENS homo sapiens homo sapiens Fujimoto, K., Yoshida, S., Tadano, G., Asada, N., Fuchino, K., Suzuki, S., Matsuoka, E., Yamamoto, T., Yamamoto, S., Ando, S., Kanegawa, N., Tonomura, Y., Ito, H., Moechars, D., Rombouts, F.J.R., Gijsen, H.J.M., Kusakabe, K.I. 2.04 X-RAY DIFFRACTION 0.254 0.207 False True IGHV3 NA NA None None None None None 1pew NA A 0 NA NA NA NA IMMUNE SYSTEM 05/22/03 High Resolution Crystal Structure of Jto2, a mutant of the non-amyloidogenic Lamba6 Light Chain, Jto HOMO SAPIENS homo sapiens Dealwis, C., Gupta, V., Wilkerson, M. 1.6 X-RAY DIFFRACTION 0.273 0.252 False True NA IGLV6 Lambda None None None None None 1bfo B A 0 ANTIBODY 05/20/98 CAMPATH-1G IGG2B RAT MONOCLONAL FAB RATTUS RATTUS rattus rattus rattus rattus Cheetham, G.M.T., Hale, G., Waldmann, H., Bloomer, A.C. 2.6 X-RAY DIFFRACTION 0.263 0.192 False False IGHV7 IGKV22 Kappa None None None None None 7dd8 A B 0 C | D protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 10/28/20 S-3C1-F1 structure, one RBD is up and two RBDs are down, the up RBD binds with a 3C1 fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 7.5 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 7zmq C NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2*-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.7 X-RAY DIFFRACTION 0.258 0.225 False True IGHV1 NA NA None None None None None 6os9 D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 05/01/19 human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G. 3 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6xli A B 0 E peptide NA tau phosphopeptide (ac-sr(pt)pslp(pt)pptre-oh) IMMUNE SYSTEM 06/28/20 CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Malia, T.J., Teplyakov, A., Luo, J. 2.0 X-RAY DIFFRACTION 0.213 0.186 False True IGHV5 IGKV14 Kappa None None None None None 4g80 E F 0 T protein voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (WT, 3.8 A) HOMO SAPIENS; CIONA INTESTINALIS homo sapiens homo sapiens ciona intestinalis Li, Q. 3.58 X-RAY DIFFRACTION 0.292 0.248 False True IGHV3 IGKV1 Kappa None None None None None 7pg8 B A 0 E protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 3chn B M 0 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 5icy D C 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with linear meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.5 X-RAY DIFFRACTION 0.206 0.160 False True IGHV2 IGKV5 Kappa 8.7e-06 -6.903730949189437 Unknown TBD 7paf B NA 0 D protein NA licb protein TRANSPORT PROTEIN 07/29/21 Streptococcus pneumoniae choline importer LicB in lipid nanodiscs SYNTHETIC CONSTRUCT; STREPTOCOCCUS PNEUMONIAE TIGR4 synthetic construct streptococcus pneumoniae tigr4 Perez, C., Baerland, N. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6mpg 5 6 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6mqs C D 0 F peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 10/10/18 Vaccine-elicited NHP FP-targeting HIV neutralizing antibody A12V163-a.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.997 X-RAY DIFFRACTION 0.247 0.233 False True IGHV4 IGLV1 Lambda None None None None None 6h72 D NA 0 B protein NA capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-94 and 2-fucosyllactose (2FL) NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 2.3 X-RAY DIFFRACTION 0.202 0.172 False True IGHV1 NA NA None None None None None 6mtj D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/19/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies 3H109L and 35O22 at 2.9 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.336 X-RAY DIFFRACTION 0.282 0.233 False True unknown unknown unknown None None None None None 4grw F NA 0 C protein interleukin-23 subunit alpha IMMUNE SYSTEM 08/27/12 Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) LLAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C. 2.55 X-RAY DIFFRACTION 0.218 0.183 False True IGHV1 None None None None None 7xji N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/18/22 Solabegron-activated dog beta3 adrenergic receptor HOMO SAPIENS; RATTUS NORVEGICUS; UNIDENTIFIED; CANIS LUPUS FAMILIARIS; BOS TAURUS unidentified homo sapiens | rattus norvegicus Shihoya, W., Nureki, O. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7lvu A NA 0 NA NA NA NA IMMUNE SYSTEM 02/26/21 Structure of RSV F-directed VHH Cl184 LAMA GLAMA lama glama Hsieh, C.-L., McLellan, J.S. 1.94 X-RAY DIFFRACTION 0.233 0.208 False True IGHV1 NA NA None None None None None 3na9 H L 0 IMMUNE SYSTEM 06/01/10 Crystal structure of Fab15 HOMO SAPIENS homo sapiens homo sapiens Luo, J. 1.7 X-RAY DIFFRACTION 0.197 0.168 False True IGHV5 IGKV1 Kappa None None None None None 7mdp H I 0 A protein NA isoform 2b of gtpase kras HYDROLASE/Immune System 04/05/21 KRas G12C in complex with G-2897 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oh, A., Frank, Y., Wang, W. 1.96 X-RAY DIFFRACTION 0.229 0.195 False True IGHV4 IGLV1 Lambda None None None None None 4x7s H L 0 IMMUNE SYSTEM 12/09/14 Structure of omalizumab Fab fragment crystal form 1 HOMO SAPIENS homo sapiens homo sapiens Jensen, R.K., Andersen, G.R. 1.9 X-RAY DIFFRACTION 0.233 0.200 False True IGHV3 IGKV1 Kappa 1e-08 -10.913952715282035 Unknown TBD 7swd I i 0 B protein NA virion spike glycoprotein VIRAL PROTEIN/Immune System 11/19/21 Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound ZAIRE EBOLAVIRUS (STRAIN GABON-94); ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens zaire ebolavirus Milligan, J.C., Yu, X., Saphire, E.O. 3.59 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5c9k NA F 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 6ayz B D 0 A protein histone chaperone asf1 IMMUNE SYSTEM 09/08/17 Crystal structure of Asf1-Fab 12E complex HOMO SAPIENS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C) homo sapiens homo sapiens saccharomyces cerevisiae (strain atcc 204508 /s288c) Bailey, L.J., Kossiakoff, A.A. 2.096 X-RAY DIFFRACTION 0.236 0.191 False True IGHV3 IGKV1 Kappa None None None None None 4uih F G 0 C protein dengue virus serotype 2 strain new guinea-c e proteinectodomain 03/30/15 Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human antibody 2D22 Fab at 37 degree C. The Fab molecules were added to the virus before 37 degree C incubation. DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., deSilva, A.M., Harris, E., Crowe, J.E., Lok, S.-M. 20.0 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 6q1g H L 0 IMMUNE SYSTEM 08/04/19 Human antibody H1244 of the human antibody lineage 652 HOMO SAPIENS homo sapiens homo sapiens McCarthy, K.R., Harrison, S.C. 1.75 X-RAY DIFFRACTION 0.206 0.180 False True IGHV4 IGLV3 Lambda None None None None None 6uqr C c 0 D protein ige IMMUNE SYSTEM 10/21/19 Complex of IgE and Ligelizumab HOMO SAPIENS homo sapiens homo sapiens Tarchevskaya, S.S., Kleinboelting, S., Jardetzky, T.S. 3.65029 X-RAY DIFFRACTION 0.295 0.290 True True unknown unknown unknown None None None None None 6niu H L 0 Z protein envelope protein e Viral protein/IMMUNE SYSTEM 12/31/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 in complex with ZIKV E glycoprotein HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 4.303 X-RAY DIFFRACTION 0.359 0.264 False True IGHV4 IGLV1 Lambda None None None None None 1mak NA A 6 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4imk A D 0 IMMUNE SYSTEM 01/03/13 Uncrossed Fab binding to human Angiopoietin 2 HOMO SAPIENS homo sapiens homo sapiens Fenn, S., Schiller, C., Griese, J.J., Hopfner, K.-P., Kettenberger, H. 2.202 X-RAY DIFFRACTION 0.226 0.199 False True IGHV1 IGLV3 Lambda None None None None None 6lxj E F 0 B protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9) INFLUENZA A VIRUS (A/ANHUI/1-BALF_RG44/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1-balf_rg44/2013(h7n9)) Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 2.903 X-RAY DIFFRACTION 0.241 0.193 False True IGHV1 IGLV2 Lambda None None None None None 6cwd G g 0 H protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/30/18 Hepatitis B core-antigen in complex with scFv e13 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS GENOTYPE D SUBTYPE ADW oryctolagus cuniculus hepatitis b virus genotype d subtype adw Eren, E., Steven, A.C., Wingfield, P.T. 3.33 X-RAY DIFFRACTION 0.282 0.242 True True unknown unknown unknown None None None None None 1ahw E D 0 F protein tissue factor COMPLEX (IMMUNOGLOBULIN/TISSUE FACTOR) 04/10/97 A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.285 0.217 False False IGHV14 IGKV14 Kappa None None None None None 6cue H L 0 D protein envelope glycoprotein gp41 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5y9f X W 0 G protein NA major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 6vrt H L 0 IMMUNE SYSTEM 02/09/20 LT1009 humanized antibody Fab fragment in complex with calcium MUS MUSCULUS mus musculus mus musculus Fleming, J.K., Huxford, T. 2.555 X-RAY DIFFRACTION 0.260 0.209 False True IGHV5 IGKV17 Kappa None None None None None 7uar F G 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/13/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1717 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5gzo C D 0 B protein genome polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/16 Structure of neutralizing antibody bound to Zika envelope protein HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F. 2.755 X-RAY DIFFRACTION 0.277 0.231 False True IGHV4 IGKV1 Kappa 1.6359999999999998e-07 -9.258056023338968 SPR TBD 6pzy I L 0 F protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-73 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.17 ELECTRON MICROSCOPY False True IGHV4 IGLV1 Lambda None None None None None 6x9x NA B 0 NA NA NA NA ANTIVIRAL PROTEIN, IMMUNE SYSTEM 06/03/20 Crystal structure of Fab fragment of Anti-HCV E2 antibody (HC84.26) HOMO SAPIENS homo sapiens Shahid, S., Mariuzza, R.A. 1.8 X-RAY DIFFRACTION 0.210 0.178 False True NA IGLV3 Lambda None None None None None 5mu2 K L 0 U peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 4llv H L 0 IMMUNE SYSTEM 07/09/13 The structure of the unbound form of anti-HIV antibody 4E10 Fv HOMO SAPIENS homo sapiens homo sapiens Finton, K.A.K., Rupert, P.B., Strong, R.K. 2.39 X-RAY DIFFRACTION 0.245 0.216 False True IGHV1 IGKV3 Kappa None None None None None 5jpj NA B 0 IMMUNE SYSTEM 05/03/16 Crystal structure of 6aJL2-R24G HOMO SAPIENS homo sapiens Pelaez-Aguilar, A.E., Diaz-Vilchis, A., Amero, C., Becerril, B., Rudino-Pinera, E. 2.0 X-RAY DIFFRACTION 0.249 0.195 False True IGLV6 Lambda None None None None None 3lqa H L 0 G | C protein | protein NA | NA envelope glycoprotein gp160 | t-cell surface glycoprotein cd4 IMMUNE SYSTEM 02/08/10 Crystal structure of clade C gp120 in complex with sCD4 and 21c Fab HOMO SAPIENS; HIV-1 homo sapiens homo sapiens hiv-1 | homo sapiens Diskin, R., Marcovecchio, P.M., Bjorkman, P.J. 3.4 X-RAY DIFFRACTION 0.322 0.234 False True IGHV1 IGLV1 Lambda 1.60e-06 -7.9 SPR 25 20357769 7omn C NA 0 NA NA NA NA IMMUNE SYSTEM 05/24/21 Anti-EphA1 JD1-1 VH domain HOMO SAPIENS homo sapiens Ereno Orbea, J., Nilvebrant, J., Sidhu, S., Julien, J.P. 1.7 X-RAY DIFFRACTION 0.222 0.203 False True IGHV3 NA NA None None None None None 6fys H NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 5whj H L 0 IMMUNE SYSTEM 07/17/17 Crystal structure of Fab fragment of anti-FcRn antibody DX-2507 HOMO SAPIENS homo sapiens homo sapiens Edwards, T.E., Fairman, J.W., Nixon, A.E., Kenniston, J.A. 2.15 X-RAY DIFFRACTION 0.225 0.180 False True IGHV3 IGLV2 Lambda None None None None None 6e63 B C 0 A protein pf48/45 IMMUNE SYSTEM 07/23/18 Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody TB31F PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Kundu, P., Semesi, A., Julien, J.P. 2.6 X-RAY DIFFRACTION 0.240 0.202 False True IGHV3 IGLV6 Lambda 3.7000000000000005e-09 -11.503030961041175 SPR TBD 4s11 A NA 0 IMMUNE SYSTEM 01/07/15 Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis LAMA GLAMA lama glama Wongsantichon, J., Loonchanta, A., Robinson, R.C., Gettemans, J. 1.998 X-RAY DIFFRACTION 0.206 0.159 False True IGHV1 None None None None None 6i07 B b 0 D protein epithelial cell adhesion molecule IMMUNE SYSTEM 10/25/18 Crystal structure of EpCAM in complex with scFv HOMO SAPIENS homo sapiens homo sapiens Casaletto, J.B., Geddie, M.L., Abu-Yousif, A.O., Masson, K., Fulgham, A., Boudot, A., Maiwald, T., Kearns, J.D., Kohli, N., Su, S., Razlog, M., Raue, A., Kalra, A., Hakansson, M., Logan, D.T., Welin, M., Chattopadhyay, S., Harms, B.D., Nielsen, U.B., Schoeberl, B., Lugovskoy, A.A., MacBeath, G. 2.35 X-RAY DIFFRACTION 0.279 0.230 True True unknown unknown unknown None None None None None 3lh2 K O 0 V protein 4e10_1vi7a_s0_002_n (t88) IMMUNE SYSTEM 01/21/10 Crystal structure of HIV epitope-scaffold 4E10_1VI7A_S0_002_N 4E10 Fv complex ARTIFICIAL GENE; HOMO SAPIENS homo sapiens homo sapiens artificial gene Holmes, M.A. 2.65 X-RAY DIFFRACTION 0.270 0.222 False True IGHV1 IGKV3 Kappa 5.60e-09 -11.25 SPR 20826338 3oaz M K 0 IMMUNE SYSTEM 08/06/10 A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity HOMO SAPIENS homo sapiens homo sapiens Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G 1.75 X-RAY DIFFRACTION 0.217 0.176 False True IGHV3 IGKV1 Kappa None None None None None 1zvo C B 0 IMMUNE SYSTEM 06/02/05 Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering HOMO SAPIENS homo sapiens homo sapiens Sun, Z., Almogren, A., Furtado, P.B., Chowdhury, B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV4 IGLV1 Lambda None None None None None 6xcm H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/08/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6iw2 K L 0 J protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state YELLOW FEVER VIRUS (STRAIN 17D VACCINE); HOMO SAPIENS homo sapiens homo sapiens yellow fever virus (strain 17d vaccine) Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 2.9 X-RAY DIFFRACTION 0.272 0.238 False True IGHV4 IGKV1 Kappa None None None None None 7ws1 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4xvu C D 0 B protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/28/15 Structure of Get3 bound to the transmembrane domain of Nyv1 SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE; HOMO SAPIENS, SYNTHETIC CONSTRUCT homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.35 X-RAY DIFFRACTION 0.234 0.197 False True IGHV3 IGKV1 Kappa None None None None None 4s1q H L 0 G protein hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 01/14/15 Crystal structure of a VRC01-lineage antibody, 45-VRC01.H03+06.D-001739, in complex with clade A/E HIV-1 gp120 core HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kwon, Y.D., Yang, Y., Zhang, B., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.258 0.219 False True unknown IGKV3 Kappa None None None None None 3j5m D C 0 A protein bg505 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/13 Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lyumkis, D., Julien, J.-P., Wilson, I.A., Ward, A.B. 5.8 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 7kn5 C NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobodies VHH E and U SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 1.87 X-RAY DIFFRACTION 0.213 0.177 False True IGHV1 NA NA None None None None None 3b2u T U 0 S protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 6cdi 3 4 0 A protein glycoprotein gp41 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7jv6 F G 0 E protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (closed conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV7 Lambda None None None None None 7nd4 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-88 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 3pnw W V 0 X protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 6vor C D 0 NA NA NA NA IMMUNE SYSTEM 01/31/20 Crystal structure of macaque anti-HIV-1 antibody RM20E1 MACACA MULATTA macaca mulatta macaca mulatta Yuan, M., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.252 0.224 False True IGHV5 IGKV2 Kappa None None None None None 3q6f H G 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 3.192 X-RAY DIFFRACTION 0.243 0.199 False False IGHV3 IGLV3 Lambda None None None None None 1lgv NA A 0 IMMUNE SYSTEM 04/16/02 Structure of a Human Bence-Jones Dimer Crystallized in U.S. Space Shuttle Mission STS-95: 100K HOMO SAPIENS homo sapiens Terzyan, S.S., DeWitt, C.R., Ramsland, P.A., Bourne, P.C., Edmundson, A.B. 1.95 X-RAY DIFFRACTION 0.245 0.200 False False IGLV2 Lambda None None None None None 7lsb B D 0 NA NA NA NA ANTITUMOR PROTEIN,IMMUNE SYSTEM 02/18/21 Structure of B1, a monoclonal VEGFR2 antibody parental of KD035 HOMO SAPIENS homo sapiens homo sapiens Depetris, R.S. 2.492 X-RAY DIFFRACTION 0.254 0.184 False True IGHV3 IGLV3 Lambda None None None None None 5u4l B NA 0 A protein ricin HYDROLASE/IMMUNE SYSTEM 12/05/16 RTA-V1C7_G29R-high-salt RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Mantis, N. 2.5 X-RAY DIFFRACTION 0.257 0.209 False True IGHV1 None None None None None 5ezj A B 0 IMMUNE SYSTEM 11/26/15 Crystal Structure of Fab of parasite invasion inhibitory antibody c1 - orthorhombic form HOMO SAPIENS homo sapiens homo sapiens Favuzza, A., Pluschke, G., Rudolph, M.G. 1.95 X-RAY DIFFRACTION 0.247 0.198 False True IGHV4 IGKV6 Kappa None None None None None 4ydk H L 0 G protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 02/22/15 Crystal structure of broadly and potently neutralizing antibody C38-VRC16.01 in complex with HIV-1 clade AE strain 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Zheng, A., Kwong, P.D. 2.051 X-RAY DIFFRACTION 0.206 0.166 False True IGHV3 IGKV1 Kappa None None None None None 7nir F NA 0 A | B protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit VIRAL PROTEIN 02/13/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (strain a/brevigmission/1/1918 h1n1) | influenza a virus (strain a/brevigmission/1/1918 h1n1) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 6.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6rvc F NA 0 C protein protein patched homolog 1 MEMBRANE PROTEIN 05/31/19 Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Rudolf, A.F., Kowatsch, C., El Omari, K., Malinauskas, T., Kinnebrew, M., Ansell, T.B., Bishop, B., Pardon, E., Schwab, R.A., Qian, M., Duman, R., Covey, D.F., Steyaert, J., Wagner, A., Sansom, M.S.P., Rohatgi, R., Siebold, C. 2.2 X-RAY DIFFRACTION 0.241 0.204 False True IGHV1 None None None None None 5cjx A C 0 J | K protein | protein NA | NA bg505 env gp41 | bg505 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 Crystal structure of 8ANC195 Fab in complex with BG505 SOSIP.664 HIV-1 Env trimer HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Scharf, L., Bjorkman, P.J. 3.584 X-RAY DIFFRACTION 0.286 0.239 False True unknown IGKV1 Kappa None None None None None 6ktr A B 0 C protein NA fibroblast growth factor 19 IMMUNE SYSTEM/PROTEIN BINDING 08/28/19 Crystal structure of fibroblast growth factor 19 in complex with Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liu, H., Zheng, S., Hou, X., Liu, X., Lv, X., Li, Y., Li, W., Sui, J. 2.59776 X-RAY DIFFRACTION 0.253 0.202 False True IGHV3 IGLV2 Lambda None None None None None 7su0 I M 0 D protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 11/15/21 Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, P.S., Chau, B., Strop, P. 2.41 X-RAY DIFFRACTION 0.264 0.206 False True IGHV3 IGKV3 Kappa None None None None None 7phw B C 0 A protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/18/21 PfCyRPA bound to monoclonal antibody Cy.004 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 2.793 X-RAY DIFFRACTION 0.277 0.239 False True unknown unknown unknown None None None None None 5anm H L 0 F protein ig epsilon chain c region 09/07/15 Crystal structure of IgE Fc in complex with a neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cohen, E.S., Dobson, C.L., Kack, H., Wang, B., Sims, D.A., Lloyd, C.O., England, E., Rees, D.G., Guo, H., Karagiannis, S.N., O'Brien, S., Persdotter, S., Ekdahl, H., Butler, R., Keyes, F., Oakley, S., Carlsson, M., Briend, E., Wilkinson, T., Anderson, I.K., Monk, P.D., vonWachenfeldt, K., Eriksson, P.O., Gould, H.J., Vaughan, T.J., May, R.D. 2.85 X-RAY DIFFRACTION 0.25993 0.19553 False True IGHV1 IGLV1 Lambda 1.95e-12 -15.975251068647337 Kinetic Exclusion Assay TBD 7cvy N O 0 L protein NA e2 glycoprotein IMMUNE SYSTEM/VIRUS 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124 MUS MUSCULUS; CHIKUNGUNYA VIRUS mus musculus mus musculus chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 5.2 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 7zwi B C 0 A protein NA gametocyte surface protein p45/48 CELL ADHESION 05/19/22 Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 1.9 X-RAY DIFFRACTION 0.217 0.189 False True IGHV5 IGKV4 Kappa None None None None None 2h8p A B 0 C protein kcsa channel MEMBRANE PROTEIN 06/07/06 Structure of a K channel with an amide to ester substitution in the selectivity filter MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Valiyaveetil, F.I., MacKinnon, R., Muir, T.W. 2.25 X-RAY DIFFRACTION 0.242 0.233 False True IGHV1 IGKV5 Kappa None None None None None 4kjq E F 0 B protein h(+)/cl(-) exchange transporter clca tranport protein, membrane protein 05/03/13 Structure of the CLC-ec1 deltaNC construct in 100mM fluoride MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C 2.875 X-RAY DIFFRACTION 0.263 0.220 False True IGHV4 IGKV4 Kappa None None None None None 6udj A R 0 P protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 2.5 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 4kkc C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 20mM Bromide MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.18 X-RAY DIFFRACTION 0.264 0.231 False True IGHV4 IGKV4 Kappa None None None None None 2gjz B A 0 IMMUNE SYSTEM 03/31/06 Structure of Catalytic Elimination Antibody 13G5 from a crystal in space group P2(1) MUS MUSCULUS mus musculus mus musculus Debler, E.W., Wilson, I.A. 2.65 X-RAY DIFFRACTION 0.250 0.213 False False IGHV2 IGKV1 Kappa None None None None None 5zxv C D 0 B protein mers-cov rbd VIRAL PROTEIN 05/21/18 Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Zhang, S., Wang, X. 4.482 X-RAY DIFFRACTION 0.343 0.307 False True IGHV3 IGLV1 Lambda 5.7600000000000006e-08 -9.87655083681725 SPR TBD 5a1z K L 0 C protein envelope protein 05/06/15 Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Jr, J.E., Lok, S.M. 6.9 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 2r4r H L 0 A protein beta-2 adrenergic receptor SIGNALING PROTEIN 08/31/07 Crystal structure of the human beta2 adrenoceptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K. 3.4 X-RAY DIFFRACTION 0.270 0.217 False False IGHV1 IGKV14 Kappa None None None None None 3q6f F E 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 3.192 X-RAY DIFFRACTION 0.243 0.199 False False IGHV3 IGLV3 Lambda None None None None None 6ii8 H L 0 C protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L4B-18 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.32 X-RAY DIFFRACTION 0.251 0.203 False True IGHV3 IGLV6 Lambda 3.8600000000000004e-07 -8.749460362550247 SPR TBD 7n9a A NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/17/21 Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS RBD with NB21 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 Sun, D., Zhang, C., Shi, Y. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6wf0 H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/Immune System 04/03/20 Crystal Structure of Broadly Neutralizing Antibody 3I14 Bound to the Influenza A H3 Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Harshbarger, W.D., Lockbaum, G.J., Deming, D.T., Attatippaholkun, N., Schiffer, C.A., Marasco, W.A. 3.46 X-RAY DIFFRACTION 0.282 0.231 False True IGHV3 IGLV1 Lambda None None None None None 6rpj D NA 0 C protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 05/14/19 A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4 HOMO SAPIENS; CAMELUS BACTRIANUS camelus bactrianus homo sapiens Gao, H., Zhou, A., Zhang, F. 3.25 X-RAY DIFFRACTION 0.262 0.249 False True IGHV1 NA NA None None None None None 7jlk H L 0 NA NA NA NA IMMUNE SYSTEM 07/29/20 Crystal structure of glVRC01 Fab in complex with anti-idiotype iv1 scFv MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M. 1.99 X-RAY DIFFRACTION 0.235 0.179 False True IGHV9 IGKV6 Kappa None None None None None 6o3a B A 0 E protein frizzled-7 SIGNALING PROTEIN 02/26/19 Crystal structure of Frizzled 7 CRD in complex with F7.B Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Raman, S., Beilschmidt, M., Fransson, J., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.242 0.192 False True IGHV3 IGKV1 Kappa None None None None None 7lyv C D 0 NA NA NA NA IMMUNE SYSTEM 03/08/21 Crystal structure of the HCMV pentamer-specific antibody 1-103 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., Jones, H.G., McLellan, J.S. 1.9 X-RAY DIFFRACTION 0.217 0.191 False True IGHV4 IGKV1 Kappa None None None None None 4jy6 B A 0 IMMUNE SYSTEM 03/29/13 Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Diwanji, D.C., Burton, D.R., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.265 0.207 False True IGHV4 unknown unknown None None None None None 5xqy NA H 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 7zfe W NA 0 A protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV1 NA NA None None None None None 4qhk I J 0 IMMUNE SYSTEM 05/28/14 UCA (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.487 X-RAY DIFFRACTION 0.285 0.269 False True IGHV4 IGLV3 Lambda None None None None None 7t3d O Q 0 G protein NA hemagglutinin ha2 chain Viral Protein/IMMUNE SYSTEM 12/07/21 CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA INFLUENZA A VIRUS (A/CALIFORNIA/04/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009(h1n1)) Han, J., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5uk2 G g 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 4 INFLUENZA A VIRUS; HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 1g9e A NA 5 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 2x6m A NA 0 B peptide NA alpha-synuclein peptide IMMUNE SYSTEM 02/18/10 Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein CAMELUS DROMEDARIUS; SYNTHETIC CONSTRUCT camelus dromedarius homo sapiens DeGenst, E., Guilliams, T., Wellens, J., O'Day, E.M., Waudby, C.A., Meehan, S., Dumoulin, M., Hsu, S.-T.D., Cremades, N., Verschueren, K.H.G., Pardon, E., Wyns, L., Steyaert, J., Christodoulou, J., Dobson, C.M. 1.62 X-RAY DIFFRACTION 0.203 0.156 False True IGHV1 NA NA None None None None None 4poy A NA 0 IMMUNE SYSTEM 02/26/14 Engineered Dual Specific VHH antibody LAMA GLAMA lama glama Fanning, S.W., Walter, R., Horn, J.R. 1.5 X-RAY DIFFRACTION 0.241 0.201 False True IGHV1 None None None None None 7czy H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2F11_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 2vyr G NA 0 C protein mdm4 protein IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 5vl3 A B 0 R protein b-cell receptor cd22 IMMUNE SYSTEM 04/24/17 CD22 d1-d3 in complex with therapeutic Fab Epratuzumab HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Sicard, T., Ereno-Orbea, J., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.295 0.280 False True IGHV1 IGKV8 Kappa None None None None None 2mmx NA A 2 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6zwk D NA 0 J peptide NA histone h2ax IMMUNE SYSTEM 07/28/20 Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens McEwen, A.G., Moeglin, E., Desplancq, D., Weiss, E., Poterszman, A. 1.55 X-RAY DIFFRACTION 0.184 0.149 False True IGHV1 NA NA None None None None None 3rhw F N 0 B protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.26 X-RAY DIFFRACTION 0.270 0.239 False True IGHV1 IGLV1 Lambda None None None None None 6iyn A NA 16 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 1f58 H L 0 P peptide protein (exterior membrane glycoprotein(gp120)) Viral protein/Immune system 10/21/98 IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 24-RESIDUE PEPTIDE (RESIDUES 308-333 OF HIV-1 GP120 (MN ISOLATE) WITH ALA TO AIB SUBSTITUTION AT POSITION 323 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Cabezas, E., Satterthwait, A.C., Stura, E.A., Profy, A.T., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.256 0.196 False False IGHV3 IGKV3 Kappa None None None None None 6pil A a 0 NA NA NA NA IMMUNE SYSTEM 06/26/19 Antibody scFv-M204 monomeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 2.2 X-RAY DIFFRACTION 0.234 0.194 True True unknown unknown unknown None None None None None 7r7n H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/25/21 SARS-CoV-2 spike in complex with the S2D106 neutralizing antibody Fab fragment (local refinement of the RBD and S2D106) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.95 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6vi4 D NA 0 A protein kappa opioid receptor MEMBRANE PROTEIN 01/11/20 Nanobody-Enabled Monitoring of Kappa Opioid Receptor States HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Che, T., Roth, B.L. 3.3 X-RAY DIFFRACTION 0.271 0.242 False True IGHV1 None None None None None 7q9g H L 0 A protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 COVOX-222 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5nhr A B 0 D protein activin receptor type-2b IMMUNE SYSTEM 03/22/17 CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM HOMO SAPIENS homo sapiens homo sapiens homo sapiens RONDEAU, J.-M. 3.35 X-RAY DIFFRACTION 0.229 0.216 False True IGHV1 IGLV2 Lambda None None None None None 1ivl NA A 0 IMMUNOGLOBULIN 05/04/94 THE DE NOVO DESIGN OF AN ANTIBODY COMBINING SITE: CRYSTALLOGRAPHIC ANALYSIS OF THE VL DOMAIN CONFIRMS THE STRUCTURAL MODEL SYNTHETIC CONSTRUCT synthetic construct Essen, L.-O., Skerra, A. 2.17 X-RAY DIFFRACTION unknown 0.175 False True IGKV6D Kappa None None None None None 5i8o H L 0 H carbohydrate FUC polysaccharide IMMUNE SYSTEM 02/19/16 HMM5 Fab in complex with disaccharide HOMO SAPIENS homo sapiens homo sapiens homo sapiens Andersen, G.R., Tjerrild, L.M., Spillner, E. 1.8 X-RAY DIFFRACTION 0.205 0.164 False True IGHV1 IGKV1 Kappa None None None None None 5boz J NA 0 D protein ricin Hydrolase/Immune system 05/27/15 Ricin A chain bound to camelid nanobody (VHH9)(E1) RICINUS COMMUNIS; LAMA GLAMA lama glama ricinus communis Rudolph, M.J., Mantis, N. 3.1 X-RAY DIFFRACTION 0.277 0.215 False True IGHV1 7e-10 -12.489520888040902 SPR TBD 6cm3 M L 0 F protein envelope glycoprotein gp160 VIRAL PROTEIN 03/02/18 BG505 SOSIP in complex with sCD4, 17b, 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 3.54 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 3dvi NA A 0 PROTEIN FIBRIL 07/18/08 Crystal structure of kappa 1 amyloidogenic light chain variable domain HOMO SAPIENS homo sapiens Thompson, J.R., Randles, E.G., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.251 0.189 False True IGKV1 Kappa None None None None None 5w3p H L 0 P peptide amyloid beta a4 protein IMMUNE SYSTEM 06/08/17 ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.92 X-RAY DIFFRACTION 0.236 0.198 False True IGHV1 IGKV4 Kappa None None None None None 2aep H L 0 A protein neuraminidase IMMUNE SYSTEM 07/23/05 An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex. MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Venkatramani, L., Bochkareva, E., Lee, J.T., Gulati, U., Laver, W.G., Bochkarev, A., Air, G.M. 2.1 X-RAY DIFFRACTION 0.224 0.188 False False IGHV7 IGKV6 Kappa 1.20e-08 -10.8 Other 16384583 6bpc B C 0 A protein reticulocyte binding protein 2, putative CELL INVASION 11/22/17 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 4F7 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus mus musculus plasmodium vivax (strain salvador i) Gruszczyk, J., Chan, L.J., Tham, W.H. 2.66 X-RAY DIFFRACTION 0.215 0.197 False False IGHV5 IGKV6 Kappa None None None None None 7e5r P Q 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7wbj N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 12/16/21 Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus Xu, Y.N., Feng, W.B., Zhou, Q.T., Liang, A.Y., Li, J., Dai, A.T., Zhao, F.H., Yan, J.H., Chen, C.W., Li, H., Zhao, L.H., Xia, T., Jiang, Y., Xu, H.E., Yang, D.H., Wang, M.W. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6v6w D E 0 T protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 12/06/19 Crystal structure of antibody 438-B11 DSS mutant (Cys98A-100aA) in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 6.5 X-RAY DIFFRACTION 0.355 0.309 False True unknown unknown unknown None None None None None 7vnc V NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 10/10/21 Structure of the SARS-CoV-2 spike glycoprotein in complex with a human single domain antibody n3113 (UDD-state, state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Yang, Z., Wang, Y., Kong, Y., Jin, Y., Wu, Y., Ying, T. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5u1f H L 0 D | A | C protein | protein | protein NA | NA | NA bg505 ds-sosip gp120 | bg505 ds-sosip gp120 | bg505 ds-sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/28/16 CryoEM structure of BG505 DS SOSIP trimer in complex with CD4 and PGT145 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Acharya, P., Kwong, P.D., Potter, C.S., Carragher, B. 6.8 ELECTRON MICROSCOPY False True IGHV1 IGKV2 Kappa None None None None None 5zia O P 0 Q peptide phosphorylated tau peptide IMMUNE SYSTEM 03/14/18 Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, H., Wilson, I.A. 2.603 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGKV4 Kappa 3e-07 -8.898798774188476 Unknown TBD 1ad0 B A 0 IMMUNOGLOBULIN 02/19/97 FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY A5B7 HOMO SAPIENS homo sapiens homo sapiens Banfield, M.J., Brady, R.L. 2.5 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 7uar H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/13/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1717 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6opq H L 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 CD4- and 17-bound HIV-1 Env B41 SOSIP frozen with LMNG HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6cbv H L 0 B protein bril STRUCTURAL PROTEIN 02/05/18 Crystal strutcure of BRIL bound to an affinity matured synthetic antibody. HOMO SAPIENS; ESCHERICHIA COLI homo sapiens homo sapiens escherichia coli Mukherjee, S., Skrobek, B., Kossiakoff, A.A. 1.872 X-RAY DIFFRACTION 0.225 0.194 False True IGHV3 IGKV1 Kappa None None None None None 6iec H L 0 A protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R17 RIFT VALLEY FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.281 0.241 False True IGHV3 IGLV3 Lambda None None None None None 7cn2 M m 0 A protein NA major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 07/29/20 Subparticle refinement of human papillomavirus type 16 pesudovirus in complex with H16.001 Fab HUMAN PAPILLOMAVIRUS TYPE 16; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human papillomavirus type 16 He, M.Z., Li, S.W. 3.43 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 7mjh E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2i5y R Q 0 P protein exterior membrane glycoprotein(gp120) VIRAL PROTEIN/IMMUNE SYSTEM 08/26/06 Crystal structure of CD4M47, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 GP120 envelope glycoprotein and anti-HIV-1 antibody 17B HUMAN IMMUNODEFICIENCY VIRUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus Huang, C.-C., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.273 0.214 False True IGHV1 IGKV3 Kappa 2.7e-09 -11.689711339052632 SPR TBD 3tnm H L 0 IMMUNE SYSTEM 09/01/11 Crystal structure of A32 Fab, an ADCC mediating anti-HIV-1 antibody HOMO SAPIENS homo sapiens homo sapiens Wu, X., Pazgier, M. 1.85 X-RAY DIFFRACTION 0.232 0.187 False True IGHV4 IGLV2 Lambda None None None None None 1qd0 A NA 0 A Hapten RR6 3-HYDROXY-7-(4-{1-[2-HYDROXY-3-(2-HYDROXY-5-SULFO-PHENYLAZO)-BENZYL]-2-SULFO-ETHYLAMINO}-[1,2,5]TRIAZIN-2-YLAMINO)-2-(2-HYDROXY-5-SULFO-PHENYLAZO)-NAPTHALENE-1,8-DISULFONIC ACID IMMUNE SYSTEM 07/08/99 CAMELID HEAVY CHAIN VARIABLE DOMAINS PROVIDE EFFICIENT COMBINING SITES TO HAPTENS LAMA GLAMA lama glama lama glama Spinelli, S., Frenken, L.G.J., Hermans, P., Verrips, T., Brown, K., Tegoni, M., Cambillau, C. 2.5 X-RAY DIFFRACTION 0.280 0.210 False False IGHV1 None None None None None 5ku2 7 NA 0 3 protein vp3 VIRUS/Immune System 07/12/16 expanded poliovirus in complex with VHH 7A CAMELUS DROMEDARIUS; POLIOVIRUS TYPE 1 (STRAIN MAHONEY) camelus dromedarius poliovirus type 1 (strain mahoney) Strauss, M., Schotte, L., Filman, D.J., Hogle, J.M. 4.5 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6osy C D 0 B protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 7sq1 H L 0 E protein NA envelope glycoprotein gp160 Viral Protein/Immune System 11/04/21 BG505.MD39TS Env trimer in complex with Fab from antibody C05 Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Moore, A., Du, J., Xu, Z., Walker, S., Kulp, D.W., Pallesen, J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV3 Kappa None None None None None 5e99 H L 0 IMMUNE SYSTEM 10/14/15 Bovine Fab fragment F08_B11 BOS TAURUS bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.06 X-RAY DIFFRACTION 0.235 0.194 False True IGHV1 IGLV1 Lambda None None None None None 6t9e A B 0 C protein NA unknown IMMUNE SYSTEM 10/28/19 Crystal structure of a bispecific DutaFab in complex with human PDGF HOMO SAPIENS Kimbung, R., Logan, D.T., Beckmann, R., Jensen, K., Speck, J., Fenn, S., Kettenberger, H. 2.989 X-RAY DIFFRACTION 0.304 0.253 False False IGHV3 IGKV1 Kappa None None None None None 6oge E D 0 A protein receptor tyrosine-protein kinase erbb-2 transferase/immune system 04/02/19 Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hao, Y., Yu, X., Bai, Y., Huang, X. 4.36 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 7su0 H L 0 C protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 11/15/21 Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, P.S., Chau, B., Strop, P. 2.41 X-RAY DIFFRACTION 0.264 0.206 False True IGHV3 IGKV3 Kappa None None None None None 5lgh H L 0 L carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 07/07/16 Afamin antibody fragment, N14 Fab, L1- glycosilated, crystal form II, same as 5L7X, but isomorphous setting indexed same as 5L88, 5L9D MUS MUSCULUS mus musculus mus musculus mus musculus Rupp, B., Naschberger, A. 1.86 X-RAY DIFFRACTION 0.228 0.190 False False IGHV1 IGKV4 Kappa None None None None None 6elu H I 0 G protein serum resistance associated; vsg protein ANTITOXIN 09/29/17 Structure of Serum Resistance Associated protein from T. b. rhodesiense TRYPANOSOMA BRUCEI RHODESIENSE; MUS MUSCULUS mus musculus mus musculus trypanosoma brucei rhodesiense Zoll, S., Higgins, M.K. 2.3 X-RAY DIFFRACTION 0.220 0.191 False True IGHV7 IGKV3 Kappa None None None None None 6vo1 G J 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/29/20 BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6xvi B NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/22/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_A12 HELICOBACTER PYLORI (STRAIN G27); HELICOBACTER PYLORI G27 helicobacter pylori (strain g27), helicobacterpylori g27 Steyaert, J., Uchanski, T., Fischer, B. 2.596 X-RAY DIFFRACTION 0.250 0.224 False True IGHV1 NA NA None None None None None 6tcm H L 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab - crystal form I HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 1.85 X-RAY DIFFRACTION 0.190 0.168 False True IGHV3 IGKV1 Kappa None None None None None 7a3u H L 0 A protein NA envelope protein VIRAL PROTEIN 08/18/20 Crystal structure of Zika virus envelope glycoprotein in complex with the divalent F(ab')2 fragment of the broadly neutralizing human antibody EDE1 C10 ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 3.0 X-RAY DIFFRACTION 0.273 0.224 False True IGHV1 IGLV2 Lambda None None None None None 4why M N 0 B peptide epitope peptide VIRAL PROTEIN 09/24/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P21 crystal form RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.62 X-RAY DIFFRACTION 0.258 0.204 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 7c2s I M 0 B | A protein | protein NA | NA envelope protein | envelope protein VIRUS 05/09/20 Helical reconstruction of Dengue virus serotype 3 complexed with Fab C10 HOMO SAPIENS; DENGUE VIRUS 3 homo sapiens homo sapiens dengue virus 3 | dengue virus 3 Morrone, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Zhang, S., Lok, S.M. 10.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7lcn B D 0 A protein NA spike glycoprotein IMMUNE SYSTEM 01/11/21 Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1050.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 3cdf NA A 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 4ocw H L 0 IMMUNE SYSTEM 02/26/14 Crystal structure of human Fab CAP256-VRC26.06, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 3.001 X-RAY DIFFRACTION 0.233 0.193 False True IGHV3 IGLV1 Lambda None None None None None 7k90 O P 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C144 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Esswein, S.R., Bjorkman, P.J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 3idj B A 0 C peptide gp41 mper peptide analog IMMUNE SYSTEM 07/21/09 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 Fab' fragment in complex with gp41 Peptide analog ELD(Orn)WAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.229 0.229 False False IGHV2 IGKV1 Kappa None None None None None 7bsc H L 0 A protein NA non-structural protein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/30/20 Complex structure of 1G5.3 Fab bound to DENV2 NS1c DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Song, H., Qi, J., Gao, F.G. 2.31 X-RAY DIFFRACTION 0.237 0.205 False True IGHV3 IGKV3 Kappa None None None None None 7r24 C NA 0 A protein NA activity-regulated cytoskeleton-associated protein STRUCTURAL PROTEIN 02/04/22 Crystal structure of rat Arc CTD in complex with two anti-Arc nanobodies RATTUS NORVEGICUS; VICUGNA PACOS vicugna pacos rattus norvegicus Markusson, S., Kursula, P. 2.7 X-RAY DIFFRACTION 0.274 0.257 False True IGHV1 NA NA None None None None None 7sc1 M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, R40-1G8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3chn C O 2 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 4ubd Y X 0 V | M protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 08/12/14 Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Shore, D.A., Yang, H., Cho, M., Donis, R.O., Stevens, J. 3.5 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 IGKV3 Kappa None None None None None 3rkd D C 0 B protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 04/18/11 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Sivaraman, J. 1.9 X-RAY DIFFRACTION 0.217 0.189 False False IGHV8 IGKV12 Kappa 5.89e-09 -11.22 SPR 21642534 5w1k B A 0 P protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV3 IGKV1 Kappa None None None None None 3ifp C D 0 R peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 2.95 X-RAY DIFFRACTION 0.269 0.235 False True IGHV8 IGKV1 Kappa 2.45e-08 -10.38 SPR 25 19923222 1xiw H G 0 E | B protein | protein NA | NA t-cell surface glycoprotein cd3 epsilon chain | t-cell surface glycoprotein cd3 delta chain membrane protein/Immune System 09/22/04 Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Arnett, K.L., Harrison, S.C., Wiley, D.C. 1.9 X-RAY DIFFRACTION 0.241 0.204 False True IGHV1 IGKV10 Kappa None None None None None 7mjt A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 04/20/21 KcsA open gate E71V mutant with Barium SYNTHETIC CONSTRUCT; STREPTOMYCES LIVIDANS synthetic construct synthetic construct streptomyces lividans Rohaim, A., Li, J., Weingarth, M., Roux, B. 3.3 X-RAY DIFFRACTION 0.270 0.209 False True IGHV3 IGKV1 Kappa None None None None None 2h2s C D 0 A protein clc cl transporter ION TRANSPORT 05/19/06 Crystal Structure of E148A mutant of CLC-ec1 in SeCN- ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Nguitragool, W., Miller, C. 3.1 X-RAY DIFFRACTION 0.282 0.281 False False IGHV4 IGKV4 Kappa None None None None None 7ej5 J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 04/01/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4aix NA C 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rC34Y, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.8 X-RAY DIFFRACTION 0.2119 0.1684 False True IGLV3 Lambda None None None None None 1xgr B A 0 C protein unknown protein IMMUNE SYSTEM 09/17/04 Structure for antibody HyHEL-63 Y33I mutant complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS escherichia coli Li, Y., Huang, Y., Swaminathan, C.P., Smith-Gill, S.J., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.304 0.250 False True IGHV3 IGKV5 Kappa None None None None None 6xc7 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.3 and CR3022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 2.883 X-RAY DIFFRACTION 0.259 0.219 False True IGHV5 IGKV4 Kappa None None None None None 7m8l G J 0 A protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/30/21 EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6snd H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.1 X-RAY DIFFRACTION 0.267 0.238 False True IGHV4 IGKV1 Kappa None None None None None 3o11 H L 0 IMMUNE SYSTEM 07/20/10 Anti-beta-amyloid antibody c706 fab in space group c2 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.8 X-RAY DIFFRACTION 0.304 0.220 False True IGHV1 IGKV4 Kappa None None None None None 7mw5 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1jtt A NA 0 L protein NA lysozyme Immune system, Lysozyme 08/22/01 Degenerate interfaces in antigen-antibody complexes CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L. 2.1 X-RAY DIFFRACTION 0.204 0.164 False True IGHV1 NA NA None None None None None 7lex G I 0 A protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1b6d NA B 0 IMMUNOGLOBULIN 01/13/99 BENCE JONES PROTEIN DEL: AN ENTIRE IMMUNOGLOBULIN KAPPA LIGHT-CHAIN DIMER HOMO SAPIENS homo sapiens Roussel, A., Spinelli, S., Deret, S., Aucouturier, P., Cambillau, C. 2.74 X-RAY DIFFRACTION 0.265 0.207 False False IGKV1 Kappa None None None None None 7lxw H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2X333 Local Refinement HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6o3b B A 0 C protein frizzled-7 SIGNALING PROTEIN 02/26/19 Crystal structure of Frizzled 7 CRD in complex with F6 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Raman, S., Beilschmidt, M., Fransson, J., Julien, J.P. 2.5 X-RAY DIFFRACTION 0.283 0.248 False True IGHV3 IGKV1 Kappa None None None None None 4bz2 H L 0 A protein envelope protein IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX 07/23/13 Structure of dengue virus EDIII in complex with Fab 2D73 DENGUE VIRUS 4; MUS MUSCULUS mus musculus mus musculus dengue virus 4 Li, J., Watterson, D., Chang, C.W., Li, X.Q., Ericsson, D.J., Qiu, L.W., Cai, J.P., Chen, J., Fry, S.R., Cooper, M.A., Che, X.Y., Young, P.R., Kobe, B. 2.03 X-RAY DIFFRACTION 0.2247 0.2052 False False IGHV1 IGKV14 Kappa None None None None None 7ew1 E e 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 5 in complex with Gi protein HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yuan, Y., Jia, G.W., Shao, Z.H., Su, Z.M. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3bdx NA C 0 IMMUNE SYSTEM 11/15/07 Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Fuentes-Silva, D., Del Pozo Yauner, L., Becerril, B., Rodriguez-Romero, A. 2.3 X-RAY DIFFRACTION 0.246 0.205 False True IGLV6 Lambda None None None None None 6u02 H L 0 A protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/19 CryoEM-derived model of NA-63 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.05 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 7d30 A NA 0 B protein NA spike protein s1 PROTEIN BINDING 09/17/20 Structure of sybody MR17-SR31 fusion in complex with the SARS-CoV-2 S Receptor Binding domain (RBD) SYNTHETIC CONSTRUCT; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 synthetic construct severe acute respiratory syndrome coronavirus2 Li, T., Yao, H., Cai, H., Qin, W., Li, D. 2.1 X-RAY DIFFRACTION 0.236 0.195 False True IGHV1 NA NA None None None None None 1iai H L 0 COMPLEX (IMMUNOGLOBULIN IGG1/IGG2A) 12/28/93 IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX MUS MUSCULUS mus musculus mus musculus Ban, N., Escobar, C., Garcia, R., Hasel, K., Day, J., Greenwood, A., McPherson, A. 2.9 X-RAY DIFFRACTION unknown 0.210 False False IGHV9 IGKV6 Kappa None None None None None 4p2c J NA 0 E protein NA shiga toxin 2e, subunit b TOXIN 03/03/14 Complex of Shiga toxin 2e with a neutralizing single-domain antibody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Lo, A.W.H., Moonens, K., De Kerpel, M., Brys, L., Pardon, E., Remaut, H., De Greve, H. 2.818 X-RAY DIFFRACTION 0.253 0.187 False True IGHV1 NA NA None None None None None 1i3v A NA 0 NA NA NA NA IMMUNE SYSTEM 02/16/01 THREE-DIMENSIONAL STRUCTURE OF A LAMA VHH DOMAIN UNLIGANDED LAMA GLAMA lama glama Spinelli, S., Tegoni, M., Frenken, L., van Vliet, C., Cambillau, C. 2.03 X-RAY DIFFRACTION 0.250 0.212 False True IGHV1 NA NA None None None None None 7nvo n NA 0 e protein NA unknown CHAPERONE 03/15/21 Human TRiC complex in open state with nanobody bound HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 5f3b E F 0 D protein growth/differentiation factor 8 Signaling Protein/Immune System 12/02/15 Structure of myostatin in complex with chimeric RK35 antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Parris, K.D., Mosyak, L. 1.76 X-RAY DIFFRACTION 0.206 0.179 False True IGHV5 IGKV6 Kappa 3e-12 -15.720019221239749 SPR TBD 1i9r K M 0 B protein cd40 ligand CYTOKINE/IMMUNE SYSTEM 03/20/01 STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY HOMO SAPIENS homo sapiens homo sapiens homo sapiens Karpusas, M., Lucci, J., Ferrant, J., Benjamin, C., Hsu, Y.-M. 3.1 X-RAY DIFFRACTION 0.285 0.233 False False IGHV1 IGKV3D Kappa None None None None None 4rfe H L 0 IMMUNE SYSTEM 09/25/14 Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab MACACA MULATTA macaca mulatta macaca mulatta Wu, X., Gohain, N., Tolbert, W.D., Pazgier, M. 1.91 X-RAY DIFFRACTION 0.246 0.192 False True IGHV4 IGLV1 Lambda None None None None None 7nft C NA 0 A protein NA polymerase basic protein 2 VIRAL PROTEIN 02/07/21 Fujian capbinding domain in complex with Nb8208 INFLUENZA A VIRUS (A/DUCK/FUJIAN/13/2002(H5N1)); HOMO SAPIENS homo sapiens influenza a virus (a/duck/fujian/13/2002(h5n1)) Keown, J.R., Grimes, J.M., Fodor, E. 3.14 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 NA NA None None None None None 6ous Q R 0 F | E protein | protein NA | NA fusion glycoprotein f1 fused with fibritin trimerizationdomain | fusion glycoprotein f2 VIRAL PROTEIN/Immune system 05/05/19 Structure of fusion glycoprotein from human respiratory syncytial virus HUMAN RESPIRATORY SYNCYTIAL VIRUS A2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a2, humanimmunodeficiency virus 1 | human respiratory syncytial virus a2 Su, H.P. 3.4 X-RAY DIFFRACTION 0.275 0.245 False True IGHV3 IGKV1 Kappa None None None None None 4hih B A 0 A carbohydrate RAM ALPHA-L-RHAMNOSE IMMUNE SYSTEM 10/11/12 Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound rhamnose. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S, Thomson, C.A., Schrader, J.W., Pai, E.F. 2.0 X-RAY DIFFRACTION 0.236 0.224 False True IGHV3 IGKV3 Kappa None None None None None 7zfc H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Beta RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs HOMO SAPIENS; LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.24 X-RAY DIFFRACTION 0.299 0.244 False True IGHV1 IGLV1 Lambda None None None None None 6qn7 A B 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV hybrid Fab B4HC-B13LC BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.15 X-RAY DIFFRACTION 0.234 0.203 False True IGHV1 IGLV1 Lambda None None None None None 7dk7 a b 0 A protein NA sars-cov-2 s protein VIRAL PROTEIN 11/23/20 S-2H2-F3b structure, three RBDs are up and each RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 9.7 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 7mtb H L 4 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5c9k NA C 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 6iw2 Q R 0 P protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state YELLOW FEVER VIRUS (STRAIN 17D VACCINE); HOMO SAPIENS homo sapiens homo sapiens yellow fever virus (strain 17d vaccine) Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 2.9 X-RAY DIFFRACTION 0.272 0.238 False True IGHV4 IGKV1 Kappa None None None None None 6ug9 H L 0 H carbohydrate GAL polysaccharide IMMUNE SYSTEM 09/26/19 Complex of ch28/11 Fab and SSEA-4 (hexagonal form) MUS MUSCULUS mus musculus mus musculus mus musculus Soliman, C., Ramsland, P.A. 2.74 X-RAY DIFFRACTION 0.247 0.170 False True IGHV2 IGKV4 Kappa None None None None None 6jhs E D 0 C protein vp3 VIRUS 02/19/19 The cryo-EM structure of HAV bound to a neutralizing antibody-F7 HUMAN HEPATITIS A VIRUS HU/AUSTRALIA/HM175/1976; MUS MUSCULUS mus musculus mus musculus human hepatitis a virushu/australia/hm175/1976 Cao, L., Liu, P., Yang, P., Gao, Q., Li, H., Sun, Y., Zhu, L., Lin, J., Su, D., Rao, Z., Wang, X. 3.05 ELECTRON MICROSCOPY False False IGHV5 IGKV4 Kappa None None None None None 7rbv H L 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 SARS-CoV-2 Spike in complex with PVI.V6-14 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Altomare, C.G., Bajic, G. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5hcg NA L 0 IMMUNE SYSTEM 01/04/16 CRYSTAL STRUCTURE OF FREE-CODV. HOMO SAPIENS homo sapiens Vallee, F., Dupuy, A., Rak, A. 2.68 X-RAY DIFFRACTION 0.297 0.229 False True IGKV11 Kappa None None None None None 7a3q I M 0 B protein NA envelope protein e VIRAL PROTEIN 08/18/20 Crystal structure of dengue 4 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10 DENGUE VIRUS 4; HOMO SAPIENS homo sapiens homo sapiens dengue virus 4 Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 2.7 X-RAY DIFFRACTION 0.239 0.216 False True IGHV1 IGLV2 Lambda None None None None None 6h3h A B 0 IMMUNE SYSTEM 07/18/18 Fab fragment of antibody against fullerene C60 MUS MUSCULUS mus musculus mus musculus Osipov, E.M., Tikhonova, T.V. 1.92 X-RAY DIFFRACTION 0.234 0.188 False False IGHV1 IGLV1 Lambda None None None None None 7sn3 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/21 Structure of human SARS-CoV-2 spike glycoprotein trimer bound by neutralizing antibody C1C-A3 Fab (variable region) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Shankar, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 1ad9 H L 0 IMMUNOGLOBULIN 02/24/97 IGG-FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY CTM01 HOMO SAPIENS homo sapiens homo sapiens Banfield, M.J., Brady, R.L. 2.8 X-RAY DIFFRACTION 0.284 0.233 False True IGHV1 IGKV1 Kappa None None None None None 6x1w H L 0 A peptide NA aclyana-3-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC56-2) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R., Wilson, I.A., Hunter, T. 1.95 X-RAY DIFFRACTION 0.241 0.200 False True IGHV1 IGKV1 Kappa None None None None None 6j11 F G 0 B protein n-terminal domain of spike glycoprotein VIRAL PROTEIN 12/27/18 MERS-CoV spike N-terminal domain and 7D10 scFv complex MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Zhou, H., Zhang, S., Zhang, S., Tang, W., Wang, X. 3.0 X-RAY DIFFRACTION 0.225 0.188 False True IGHV1 IGKV3 Kappa None None None None None 3v6o C E 0 A protein leptin receptor IMMUNE SYSTEM 12/20/11 Leptin Receptor-antibody complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Carpenter, B., Hemsworth, G.R., Ross, R.J., Artymiuk, P.J. 1.95 X-RAY DIFFRACTION 0.213 0.171 False False IGHV2 IGKV6 Kappa None None None None None 1uwg H L 0 H Hapten KHA 1-(4-{[(2-HYDROXYETHYL)AMINO]CARBONYL}BENZYL)-1-METHYLPIPERIDINIUM ANTIBODY 02/05/04 Molecular Mechanism of Enantioselective Proton Transfer to Carbon in Catalytic Antibody 14D9 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Baumann, , U, , Reymond, , Jl, 2.79 X-RAY DIFFRACTION 0.276 0.204 False True IGHV1 IGKV6 Kappa None None None None None 1flr H L 0 L Hapten FLU 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID IMMUNOGLOBULIN 01/19/95 4-4-20 FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus mus musculus Whitlow, M. 1.85 X-RAY DIFFRACTION unknown unknown False False IGHV6 IGKV1 Kappa 5.00E-10 -12.55 Other 22 8637844 3cm9 B M 5 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7sem B C 0 F protein NA fusion glycoprotein f0 VIRAL PROTEIN/Immune System 09/30/21 Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins HOMO SAPIENS; HUMAN METAPNEUMOVIRUS homo sapiens homo sapiens human metapneumovirus Rush, S.A., Hsieh, C.-L., McLellan, J.S. 2.2 X-RAY DIFFRACTION 0.239 0.217 False True IGHV3 IGLV1 Lambda None None None None None 4iof C D 0 A protein insulin-degrading enzyme HYDROLASE 01/07/13 Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens McCord, L.A., Liang, W.G, Hoey, R., Dowdell, E., Koide, A., Koide, S., Tang, W.J. 3.353 X-RAY DIFFRACTION 0.280 0.232 False True IGHV3 IGKV1 Kappa 4e-09 -11.456840020052727 SPR TBD 1oau H L 0 H Hapten DNF 2,4-DINITROPHENOL IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 1.8 X-RAY DIFFRACTION 0.264 0.226 False True IGHV1 IGLV1 Lambda 2.00e-08 Other 20 12610298 7l09 H L 0 T carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 12/11/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound domain-swapped antibody 2G12 from masked 3D refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Manne, K., Henderson, R., Acharya, P. 3.1 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6bb4 J N 0 R peptide microtubule-associated protein tau IMMUNE SYSTEM 10/16/17 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 2.099 X-RAY DIFFRACTION 0.270 0.218 False False IGHV1 IGKV11 Kappa 1.5400000000000002e-08 -10.658128680238939 Unknown TBD 6tco H L 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form I HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 1.8 X-RAY DIFFRACTION 0.192 0.168 False True IGHV3 IGKV1 Kappa None None None None None 6iyn A NA 6 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 3h3p I M 0 T peptide 4e10_s0_1tjlc_004_n IMMUNE SYSTEM 04/16/09 Crystal structure of HIV epitope-scaffold 4E10 Fv complex HOMO SAPIENS; ARTIFICIAL GENE homo sapiens homo sapiens artificial gene Holmes, M.A. 2.7 X-RAY DIFFRACTION 0.287 0.229 False True IGHV1 IGKV3 Kappa 1.40e-08 -10.71 SPR 25 19906921 5ukb b NA 0 B protein nucleocapsid Viral Protein/RNA/Immune System 01/20/17 VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 ESCHERICHIA COLI; VESICULAR STOMATITIS INDIANA VIRUS; VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 5.473 X-RAY DIFFRACTION 0.338 0.336 False False IGHV1 None None None None None 7s4g H L 0 J peptide NA lymphocyte antigen 6 complex locus protein g6d SIGNALING PROTEIN 09/08/21 Fab fragment bound to the Cter peptide of Ly6G6D HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rouge, L., Lupardus, P. 2.2 X-RAY DIFFRACTION 0.235 0.192 False True IGHV1 IGKV4 Kappa None None None None None 6o41 H L 0 IMMUNE SYSTEM 02/27/19 Crystal structure of the unbound PGZL1 germline Fab fragment (PGZL1_gVmDmJ) HOMO SAPIENS; STREPTOCOCCUS SP. GROUP G homo sapiens homo sapiens Irimia, A., Wilson, I.A. 2.465 X-RAY DIFFRACTION 0.219 0.169 False True IGHV1 IGKV3 Kappa None None None None None 3v6o D F 0 B protein leptin receptor IMMUNE SYSTEM 12/20/11 Leptin Receptor-antibody complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Carpenter, B., Hemsworth, G.R., Ross, R.J., Artymiuk, P.J. 1.95 X-RAY DIFFRACTION 0.213 0.171 False False IGHV2 IGKV6 Kappa None None None None None 3eff B A 0 M | N protein | protein NA | NA voltage-gated potassium channel | voltage-gated potassium channel MEMBRANE PROTEIN 09/08/08 The Crystal Structure of Full-Length KcsA in its Closed Conformation MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans | streptomyces lividans Uysal, S., Vasquez, V., Tereshko, T., Esaki, K., Fellouse,F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A. 3.8 X-RAY DIFFRACTION 0.331 0.270 False False IGHV3 IGKV1 Kappa None None None None None 4jpv H L 0 G protein hiv-1 clade a strain 93th057 gp120 with loop d and loopd v5replaced from hiv strain 3415v1 viral protein/immune system 03/19/13 Crystal structure of broadly and potently neutralizing antibody 3bnc117 in complex with hiv-1 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.827 X-RAY DIFFRACTION 0.259 0.199 False True IGHV1 IGKV1 Kappa None None None None None 5f9w B C 0 A protein clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 12/10/15 Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235 in complex with HIV-1 clade A/E 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chen, L., Zhou, T., Kwong, P.D. 2.8911 X-RAY DIFFRACTION 0.232 0.180 False True IGHV1 IGKV3 Kappa None None None None None 5cws B A 0 E | C | D | F protein | protein | protein | peptide NA | NA | NA | NA nucleoporin nup57 | nucleoporin nsp1 | nucleoporin nup49 | nucleoporin nic96 PROTEIN TRANSPORT 07/28/15 Crystal structure of the intact Chaetomium thermophilum Nsp1-Nup49-Nup57 channel nucleoporin heterotrimer bound to its Nic96 nuclear pore complex attachment site HOMO SAPIENS; CHAETOMIUM THERMOPHILUM (STRAIN DSM 1495 / CBS 144.50 / IMI 039719); CHAETOMIUM THERMOPHILUM homo sapiens homo sapiens chaetomium thermophilum (strain dsm 1495 / cbs144.50 / imi 039719) | chaetomium thermophilum (strain dsm 1495 / cbs144.50 / imi 039719) | chaetomium thermophilum | chaetomium thermophilum (strain dsm 1495 / cbs144.50 / imi 039719) Bley, C.J., Petrovic, S., Paduch, M., Lu, V., Kossiakoff, A.A., Hoelz, A. 3.77 X-RAY DIFFRACTION 0.265 0.229 False True IGHV3 IGKV1 Kappa None None None None None 7ley H I 0 C protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb5 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.05 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6dcv H L 0 IMMUNE SYSTEM 05/08/18 Crystal structure of human anti-tau antibody CBTAU-27.1 HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Zhang, H., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.229 0.186 False True IGHV5 IGKV4 Kappa None None None None None 7k93 I i 0 C protein NA non-structural protein 1 VIRAL PROTEIN 09/28/20 DENV2 NS1 in complex with neutralizing 2B7 single chain Fab variable region (scFv) DENGUE VIRUS 2; MUS MUSCULUS mus musculus dengue virus 2 Akey, D.L., Smith, J.L. 2.89 X-RAY DIFFRACTION 0.269 0.223 True True unknown unknown unknown None None None None None 7z1c F NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-B5 and H11-F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 1.9 X-RAY DIFFRACTION 0.199 0.175 False True IGHV1 NA NA None None None None None 2bfv H L 0 H Hapten STG ESTRIOL 3-(B-D-GLUCURONIDE) IMMUNOGLOBULIN 05/27/97 MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI MUS MUSCULUS mus musculus mus musculus mus musculus Trinh, C.H., Phillips, S.E.V. 2.5 X-RAY DIFFRACTION unknown 0.187 False True IGHV5 IGKV1 Kappa None None None None None 5ds8 A B 0 IMMUNE SYSTEM 09/17/15 Context-independent anti-hypusine antibody FabHpu98 in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus Zhai, Q., Carter, P.J. 1.95 X-RAY DIFFRACTION 0.224 0.183 False True IGHV1 IGKV1 Kappa None None None None None 5dmj E NA 0 D protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 09/08/15 Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB HOMO SAPIENS homo sapiens homo sapiens Sheriff, S. 2.79 X-RAY DIFFRACTION 0.258 0.229 False True IGHV3 5.3e-09 -11.290107730486941 SPR TBD 6nqd G H 0 F | E protein | protein NA | NA t/f100 env gp41 | t/f100 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/21/19 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Fang, Q., Rossmann, M.G. 3.9 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5ocl D NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA lama glama Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 7php N NA 0 A protein NA multidrug resistance protein norm MEMBRANE PROTEIN 08/18/21 Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM VIBRIO CHOLERAE RC385; SYNTHETIC CONSTRUCT; LAMA GLAMA synthetic construct vibrio cholerae rc385 Bloch, J.S., Mukherjee, S., Kowal, J., Niederer, M., Pardon, E., Steyaert, J., Kossiakoff, A.A., Locher, K.P. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6do1 E NA 0 A protein type-1 angiotensin ii receptor,soluble cytochrome b562 brilfusion protein MEMBRANE PROTEIN 06/08/18 Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8 HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT synthetic construct homo sapiens, escherichia coli Wingler, L.M., McMahon, C., Staus, D.P., Lefkowitz, R.J., Kruse, A.C. 2.901 X-RAY DIFFRACTION 0.359 0.305 False True IGHV1 None None None None None 1svz b B 0 D peptide epitope peptide corresponding to n-terminus ofhiv-2 protease IMMUNE SYSTEM 03/30/04 Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus Rezacova, P., Brynda, J., Lescar, J., Bentley, G.A., Fabry, M., Horejsi, M., Sedlacek, J. 1.89 X-RAY DIFFRACTION 0.239 0.196 True True unknown unknown unknown None None None None None 7lud H L 0 NA NA NA NA IMMUNE SYSTEM 02/22/21 Crystal structure of Fab ADI-14442 HOMO SAPIENS homo sapiens homo sapiens Rush, S.A., McLellan, J.S. 2.9 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV2 Kappa None None None None None 6x87 E F 0 X protein NA circumsporozoite protein IMMUNE SYSTEM 06/01/20 CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Kucharska, I., Thai, E., Rubinstein, J., Julien, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6h0e C D 0 G peptide microtubule-associated protein tau IMMUNE SYSTEM 07/09/18 FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens mus musculus Juraszek, J., Steinbacher, S. 1.95 X-RAY DIFFRACTION 0.285 0.222 False True IGHV1 IGKV2 Kappa 2.4000000000000003e-07 -9.031007686639388 Unknown TBD 1fl3 A B 0 A Hapten SPB 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID IMMUNE SYSTEM 08/11/00 CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K MUS MUSCULUS mus musculus mus musculus mus musculus Stevens, R.C., Beuscher IV, A.E. 2.45 X-RAY DIFFRACTION 0.262 0.231 False False IGHV5 IGKV2 Kappa 1.6e-07 -9.27123914600291 Unknown TBD 6gk4 F NA 0 D protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 Human NBD1 of CFTR in complex with nanobodies D12 and T8 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.91 X-RAY DIFFRACTION 0.295 0.246 False True IGHV1 None None None None None 5m94 B NA 0 A protein divalent metal cation transporter mnth TRANSPORT PROTEIN 10/31/16 Crystal structure of Staphylococcus capitis divalent metal ion transporter (DMT) in complex with nanobody STAPHYLOCOCCUS CAPITIS; LAMA GLAMA lama glama staphylococcus capitis Dutzler, R., Ehrnstorfer, I.A. 3.101 X-RAY DIFFRACTION 0.273 0.237 False True IGHV1 None None None None None 6q23 H L 0 A protein neuraminidase VIRAL PROTEIN,HYDROLASE/IMMUNE SYSTEM 08/06/19 Crystal structure of human 1G01 Fab in complex with influenza virus neuraminidase from A/California/04/2009 (H1N1) INFLUENZA A VIRUS (A/CALIFORNIA/04/2009 (H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009 (h1n1) Zhu, X., Wilson, I.A. 3.27 X-RAY DIFFRACTION 0.241 0.196 False True IGHV3 IGKV1 Kappa None None None None None 4nyl E F 0 IMMUNE SYSTEM 12/10/13 Crystal structure of adalimumab FAB fragment HOMO SAPIENS homo sapiens homo sapiens Fan, L.J., Lv, L.L., Zhang, Q.J., Chen, C.L. 2.8 X-RAY DIFFRACTION 0.358 0.275 False True IGHV3 IGKV1 Kappa None None None None None 7n28 S U 0 G protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/28/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Gao, F. 4.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5y2k G H 0 IMMUNE SYSTEM 07/26/17 A human antibody AF4H1L1 HOMO SAPIENS homo sapiens homo sapiens Xiao, H., Qi, J., Gao, F.G. 2.1 X-RAY DIFFRACTION 0.259 0.220 False True IGHV3 IGLV3 Lambda None None None None None 1ymh D C 0 F protein protein l IMMUNE SYSTEM 01/21/05 anti-HCV Fab 19D9D6 complexed with protein L (PpL) mutant A66W FINEGOLDIA MAGNA; MUS MUSCULUS mus musculus mus musculus finegoldia magna Granata, V., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 2.6 X-RAY DIFFRACTION 0.302 0.224 False False IGHV9 IGKV8 Kappa None None None None None 2xza H L 0 IMMUNE SYSTEM 11/24/10 Crystal Structure of recombinant A.17 antibody FAB fragment HOMO SAPIENS homo sapiens homo sapiens Carletti, E., Nachon, F., Nicolet, Y., Masson, P., Kurkova, I., Smirnov, I., Friboulet, A., Tramontano, A., Gabibov, A. 1.5 X-RAY DIFFRACTION 0.21095 0.16623 False True IGHV4 IGLV1 Lambda None None None None None 5lx9 H h 0 A protein human adiponectin receptor 2 MEMBRANE PROTEIN 09/20/16 CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID AT 2.4 ANGSTROM RESOLUTION HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Vasiliauskaite-Brooks, I., Leyrat, C., Hoh, F., Granier, S. 2.4 X-RAY DIFFRACTION 0.205 0.181 True True unknown unknown unknown None None None None None 7m74 N NA 0 NA NA NA NA SIGNALING PROTEIN 03/26/21 ATP-bound AMP-activated protein kinase HOMO SAPIENS; ESCHERICHIA COLI; LAMA GLAMA lama glama Yan, Y., Mukherjee, S., Harikumar, K.G., Strutzenberg, T., Zhou, X.E., Powell, S.K., Xu, T., Sheldon, R., Lamp, J., Brunzelle, J.S., Radziwon, K., Ellis, A., Novick, S.J., Vega, I.E., Jones, R., Miller, L.J., Xu, H.E., Griffin, P.R., Kossiakoff, A.A., Melcher, K. 3.93 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7qez E F 0 A protein NA spike protein s1 VIRAL PROTEIN 12/03/21 Crystal structure of the SARS-CoV-2 RBD in complex with the ultrapotent antibody CV2.1169 and CR3022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fernandez, I., Rey, F.A. 2.89 X-RAY DIFFRACTION 0.281 0.239 False True IGHV5 IGKV4 Kappa None None None None None 3zdx H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION/IMMUNE SYSTEM 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.45 X-RAY DIFFRACTION 0.1971 0.1628 False True IGHV14 IGKV14 Kappa None None None None None 2fl5 H L 0 H Hapten RBF RIBOFLAVIN IMMUNE SYSTEM 01/05/06 Cofactor-containing antibodies: Crystal structure of the original yellow antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.290 0.240 False False IGHV3 IGLV3 Lambda 1.8000000000000002e-09 -11.929942798416155 Unknown TBD 6dl8 A B 0 IMMUNE SYSTEM 05/31/18 Crystal Structure of an influenza A hemagglutinin antibody Fab variant CH67:1203d4 chimera HOMO SAPIENS homo sapiens homo sapiens Dong, J., Finn, J.A., Crowe, J.E. 3.805 X-RAY DIFFRACTION 0.284 0.233 False True IGHV1 IGLV3 Lambda None None None None None 2xxm B NA 0 A protein capsid protein p24 IMMUNE SYSTEM/PEPTIDE 11/10/10 Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide. HUMAN IMMUNODEFICIENCY VIRUS; VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos human immunodeficiency virus Igonet, S., Vaney, M.-C., Bartonova, V., Helma, J., Rothbauer, U., Leonhardt, H., Stura, E., Krausslich, H.-G., Rey, F.A. 1.65 X-RAY DIFFRACTION 0.2166 0.1923 False True IGHV1 None None None None None 7ri2 B NA 0 A protein NA glycoprotein 120 IMMUNE SYSTEM 07/19/21 Crystal structure of anti-HIV llama VHH antibody A12 in complex with HIV-1 C1086 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.8 X-RAY DIFFRACTION 0.330 0.273 False True IGHV1 NA NA None None None None None 6b5r H L 0 A peptide pfcsp peptide 21asp-pro-asn IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 21 with human antibody CIS42 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 1.775 X-RAY DIFFRACTION 0.237 0.191 False True IGHV7 IGLV2 Lambda 1.69e-09 -11.967303714867903 Unknown TBD 7lvw L NA 0 C protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/26/21 Structure of RSV F in Complex with VHH Cl184 RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama respiratory syncytial virus Hsieh, C.-L., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.230 0.201 False True IGHV1 NA NA None None None None None 4o5i O P 0 C protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 6.501 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 IGLV1 Lambda None None None None None 5i6x B C 0 A protein sodium-dependent serotonin transporter MEMBRANE PROTEIN 02/16/16 X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Coleman, J.A., Green, E.M., Gouaux, E. 3.14 X-RAY DIFFRACTION 0.270 0.238 False True IGHV1 IGKV6 Kappa None None None None None 7t0j F E 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.15 X-RAY DIFFRACTION 0.281 0.230 False True IGHV7 IGKV8 Kappa None None None None None 6c5w C NA 0 B protein calcium uniporter MEMBRANE PROTEIN 01/17/18 Crystal structure of the mitochondrial calcium uniporter METARHIZIUM ACRIDUM (STRAIN CQMA 102); ESCHERICHIA COLI K-12 escherichia coli k-12 metarhizium acridum (strain cqma 102) Fan, C., Fan, M., Fastman, N., Zhang, J., Feng, L. 3.1001 X-RAY DIFFRACTION 0.299 0.256 False True IGHV1 None None None None None 6mfj H L 0 IMMUNE SYSTEM 09/11/18 Crystal structure of the ADCC potent antibody DH677.3 Fab elicited in the RV305 vaccine trial. HOMO SAPIENS homo sapiens homo sapiens Young, B., Tolbert, W.D., Pazgier, M. 2.62 X-RAY DIFFRACTION 0.261 0.199 False True IGHV1 IGKV1 Kappa None None None None None 5f8r C NA 0 A protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain S831 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.44 X-RAY DIFFRACTION 0.219 0.189 False True IGHV1 None None None None None 6id4 H L 0 A | B protein | protein NA | NA mhc class i antigen | beta-2-microglobulin IMMUNE SYSTEM 09/08/18 Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Lescar, J., Wong, Y.H., Liew, C.W., Gu, Y., MacAry, P.A. 2.4 X-RAY DIFFRACTION 0.246 0.197 False True IGHV1 IGLV5 Lambda None None None None None 7pbz F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 08/03/21 a1b3 GABA-A receptor + GABA + Zn2+ LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Miller, P.S., Kasaragod, V.B. 2.79 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4g6f H L 0 P peptide gp41 mper peptide IMMUNE SYSTEM 07/19/12 Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Huang, J., Connors, M., Kwong, P.D. 2.1 X-RAY DIFFRACTION 0.218 0.180 False True IGHV3 IGLV3 Lambda 1.7e-08 -10.599564136380756 Unknown TBD 7wig S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 01/03/22 Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Chen, L., Wang, W., Dong, Y., Shen, D., Guo, J., Qin, J., Zhang, H., Shen, Q., Zhang, Y., Mao, C. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3uaj H L 0 A protein envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 10/21/11 Crystal structure of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 DENGUE VIRUS 4; PAN TROGLODYTES pan troglodytes pan troglodytes dengue virus 4 Cockburn, J.J.B., Stura, E.A., Navarro-Sanchez, M.E., Rey, F.A. 3.232 X-RAY DIFFRACTION 0.246 0.241 False True IGHV4 IGKV1 Kappa 2.9e-09 -11.647373069103503 Unknown TBD 5bzd B A 0 IMMUNE SYSTEM 06/11/15 Crystal Structure of PCDN-27A, an antibody from the PCDN family of HIV-1 antibodies HOMO SAPIENS homo sapiens homo sapiens Garces, F., WILSON, I.A. 2.7 X-RAY DIFFRACTION 0.247 0.211 False True IGHV4 IGKV3 Kappa None None None None None 6xvi D NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/22/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_A12 HELICOBACTER PYLORI (STRAIN G27); HELICOBACTER PYLORI G27 helicobacter pylori (strain g27), helicobacterpylori g27 Steyaert, J., Uchanski, T., Fischer, B. 2.596 X-RAY DIFFRACTION 0.250 0.224 False True IGHV1 NA NA None None None None None 6k6a NA B 0 C protein engineered protein a STRUCTURAL PROTEIN 06/02/19 Application of anti-helix antibodies in protein structure determination (8188cys-3LRHcys) HOMO SAPIENS; STAPHYLOCOCCUS AUREUS homo sapiens staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.94 X-RAY DIFFRACTION 0.215 0.169 False True IGLV1 Lambda None None None None None 4gmt I M 0 IMMUNE SYSTEM 08/16/12 Crystal structure of heterosubtypic Fab S139/1 MUS MUSCULUS mus musculus mus musculus Lee, P.S., Ekiert, D.C., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.209 0.158 False True IGHV1 IGKV6 Kappa None None None None None 6mwx K L 0 J protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-69 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 8.2 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 7zr7 H L 0 B protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/03/22 OMI-42 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; TEQUATROVIRUS T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7s4g A B 0 K peptide NA lymphocyte antigen 6 complex locus protein g6d SIGNALING PROTEIN 09/08/21 Fab fragment bound to the Cter peptide of Ly6G6D HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rouge, L., Lupardus, P. 2.2 X-RAY DIFFRACTION 0.235 0.192 False True IGHV1 IGKV4 Kappa None None None None None 6zpl E NA 0 B protein NA sodium- and chloride-dependent glycine transporter 1 MEMBRANE PROTEIN 07/08/20 Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor, sybody Sb_GlyT1#7 and bound Na and Cl ions. HOMO SAPIENS; HUNGATEICLOSTRIDIUM THERMOCELLUM (STRAIN ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372); UNIDENTIFIED unidentified homo sapiens Shahsavar, A., Stohler, P., Bourenkov, G., Zimmermann, I., Siegrist, M., Guba, W., Pinard, E., Sinning, S., Seeger, M.A., Schneider, T.R., Dawson, R.J.P., Nissen, P. 3.945 X-RAY DIFFRACTION 0.291 0.277 False True IGHV1 NA NA None None None None None 7m6f C D 0 E protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, BG1-22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 3nh7 H L 0 A protein bone morphogenetic protein receptor type-1a IMMUNE SYSTEM 06/14/10 Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mueller, T.D., Harth, S., Sebald, W. 2.7 X-RAY DIFFRACTION 0.280 0.234 False True IGHV3 IGLV3 Lambda 2.00e-08 -10.5 SPR 25 20927405 7tca D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 4lhq D NA 0 C protein NA ricin HYDROLASE/IMMUNE SYSTEM 07/01/13 Ricin A chain bound to camelid nanobody (VHH8) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Cheung, J., Franklin, M., Burshteyn, F., Cassidy, M., Gary, E., Mantis, N. 2.3 X-RAY DIFFRACTION 0.248 0.192 False True IGHV1 NA NA None None None None None 7zmm G NA 0 D protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.5 X-RAY DIFFRACTION 0.281 0.240 False True IGHV1 NA NA None None None None None 5aze H L 0 IMMUNE SYSTEM 10/02/15 Fab fragment of calcium-dependent antigen binding antibody, 6RL#9 HOMO SAPIENS homo sapiens homo sapiens Kadono, S., Hironiwa, N., Ishii, S., Igawa, T., Hattori, K. 2.2 X-RAY DIFFRACTION 0.272 0.211 False True IGHV1 IGLV1 Lambda None None None None None 7kh0 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/19/20 Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Wang, L., Xu, J., Gao, S., Sun, D., Liu, H., Liu, Z., Du, Y., Zhang, C. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5drn H L 0 IMMUNE SYSTEM 01/20/16 Context-independent anti-hypusine antibody FabHpu24 in complex with hypusine ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Zhai, Q., Carter, P.J. 1.994 X-RAY DIFFRACTION 0.222 0.183 False True IGHV1 IGKV1 Kappa None None None None None 4wuu E D 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, a-2 alpha chain | arg-met-phe-pro-asn-ala-pro-tyr-leu IMMUNE SYSTEM 11/03/14 Structure of ESK1 in complex with HLA-A*0201/WT1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Ataie, N.J., Ng, H.L. 3.047 X-RAY DIFFRACTION 0.254 0.198 False True IGHV5 IGLV1 Lambda 1.32e-08 -10.749460442297496 SPR TBD 6wtv H I 0 G protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 258259 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.05 X-RAY DIFFRACTION 0.277 0.235 False True IGHV3 IGLV3 Lambda None None None None None 7whi D NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 2 complex structure of Omicron spike with Bn03 (2-up RBD, 4 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7mfr Y X 0 Q peptide NA gly-gly-met IMMUNE SYSTEM 04/10/21 Crystal Structure of a Fab fragment bound to peptide GGM ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Sudhamsu, J. 2.848 X-RAY DIFFRACTION 0.260 0.211 False True IGHV1 IGKV1 Kappa None None None None None 3u36 A B 0 IMMUNE SYSTEM 10/04/11 Crystal Structure of PG9 Fab HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Kwong, P.D. 3.281 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV2 Lambda None None None None None 6hjx H NA 0 C protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.5 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 None None None None None 6k2i A NA 15 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 1tet H L 0 P peptide cholera toxin peptide 3 (ctp3) IMMUNOGLOBULIN 06/21/93 CRYSTAL STRUCTURE OF AN ANTICHOLERA TOXIN PEPTIDE COMPLEX AT 2.3 ANGSTROMS MUS MUSCULUS mus musculus mus musculus Shoham, M. 2.3 X-RAY DIFFRACTION unknown 0.148 False False IGHV9 IGKV1 Kappa 8.30e-07 -8.24 Other 23 7690406 7dx4 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 01/18/21 The structure of FC08 Fab-hA.CE2-RBD complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cao, L., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7ra8 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/30/21 SARS-CoV-2 S glycoprotein in complex with S2X259 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Veesler, D., Tortorici, M.A., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5fv2 B NA 0 V protein vascular endothelial growth factor 02/02/16 Crystal structure of hVEGF in complex with VH domain antibody HOMO SAPIENS homo sapiens homo sapiens Chung, C., Batuwangala, T. 3.45 X-RAY DIFFRACTION 0.26270 0.21244 False True IGHV3 7.1699999999999995e-12 -15.203792121426005 SPR TBD 4gft B NA 0 A protein myosin a tail domain interacting protein protein binding, immune system 08/03/12 Malaria invasion machinery protein-Nanobody complex PLASMODIUM FALCIPARUM 3D7; LAMA GLAMA lama glama plasmodium falciparum 3d7 Khamrui, S., Turley, S., Pardon, E., Steyaert, J., Verlinde, C., Fan, E., Bergman, L.W., Hol, W.G.J. 1.6 X-RAY DIFFRACTION 0.205 0.181 False True IGHV1 None None None None None 7eh3 A NA 5 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6xvi C NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/22/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_A12 HELICOBACTER PYLORI (STRAIN G27); HELICOBACTER PYLORI G27 helicobacter pylori (strain g27), helicobacterpylori g27 Steyaert, J., Uchanski, T., Fischer, B. 2.596 X-RAY DIFFRACTION 0.250 0.224 False True IGHV1 NA NA None None None None None 7l2c H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/Viral Protein 12/16/20 Crystallographic structure of neutralizing antibody 2-51 in complex with SARS-CoV-2 spike N-terminal domain (NTD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Reddem, E.R., Shapiro, L. 3.65 X-RAY DIFFRACTION 0.272 0.216 False True IGHV1 IGLV2 Lambda None None None None None 5u3p H L 0 IMMUNE SYSTEM 12/02/16 Crystal Structure of DH511.4 Fab HOMO SAPIENS homo sapiens homo sapiens Nicely, N.I., Williams, L.D., Ofek, G., Haynes, B.F. 1.5 X-RAY DIFFRACTION 0.211 0.188 False True IGHV3 IGKV1 Kappa None None None None None 5ldn H L 0 A protein hexon protein,hexon capsid VIRAL PROTEIN 06/27/16 A viral capsid:antibody complex HUMAN ADENOVIRUS C SEROTYPE 5; HUMAN ADENOVIRUS 5; MUS MUSCULUS mus musculus mus musculus human adenovirus c serotype 5, human adenovirus5 James, L. 2.7 X-RAY DIFFRACTION 0.223 0.164 False True IGHV2 IGKV6 Kappa None None None None None 7l0n A B 0 R protein NA spike protein s1 VIRAL PROTEIN/HYDROLASE 12/11/20 Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Dillen, J., Nix, J.C., Croll, T.I., Corti, D. 2.78 X-RAY DIFFRACTION 0.325 0.290 False True IGHV1 IGKV3 Kappa None None None None None 6opq M O 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 CD4- and 17-bound HIV-1 Env B41 SOSIP frozen with LMNG HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1rzi D C 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 3p9w F NA 0 E protein vascular endothelial growth factor a SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/10 Crystal structure of an engineered human autonomous VH Domain in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens Ma, X., Wiesmann, C. 2.41 X-RAY DIFFRACTION 0.233 0.193 False True IGHV3 1.6e-08 -10.635483235413165 SPR TBD 7shy E F 0 B protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with omalizumab scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.230 0.173 False True IGHV3 IGKV1 Kappa None None None None None 2kqn NA B 2 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1p84 J K 0 E protein ubiquinol-cytochrome c reductase iron-sulfursubunit OXIDOREDUCTASE 05/06/03 HDBT inhibited Yeast Cytochrome bc1 Complex MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Palsdottir, H., Lojero, C.G., Trumpower, B.L., Hunte, C. 2.5 X-RAY DIFFRACTION 0.252 0.228 False True IGHV3 IGKV10 Kappa None None None None None 1c12 B A 0 A Hapten TRZ TRAZEOLIDE IMMUNE SYSTEM 07/20/99 INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE MUS MUSCULUS mus musculus mus musculus mus musculus Langedijk, A.C., Spinelli, S., Anguille, C., Hermans, P., Nederlof, J., Butenandt, J., Honegger, A., Cambillau, C., Pluckthun, A. 2.6 X-RAY DIFFRACTION 0.270 0.205 False True IGHV3 IGKV14 Kappa 1.90e-09 -11.57 Other 17 10525411 4h88 H L 0 A protein major prion protein IMMUNE SYSTEM 09/21/12 Structure of POM1 FAB fragment complexed with mouse PrPc Fragment 120-230 MUS MUSCULUS mus musculus mus musculus mus musculus Baral, P.K., Wieland, B., Swayampakula, M., James, M.N. 1.9 X-RAY DIFFRACTION 0.234 0.199 False False IGHV1 IGKV5 Kappa 2.9e-09 -11.647373069103503 SPR TBD 3eyq D C 0 IMMUNE SYSTEM 10/21/08 Crystal structure of MJ5 Fab, a germline antibody variant of anti-human cytomegalovirus antibody 8f9 HOMO SAPIENS homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.4 X-RAY DIFFRACTION 0.270 0.250 False True IGHV3 IGKV3 Kappa None None None None None 5uoe P Q 0 C protein insulin-degrading enzyme Hydrolase/Immune System 01/31/17 Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J. 3.8 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV1 Kappa None None None None None 4nhg D B 0 IMMUNE SYSTEM 11/05/13 Crystal Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West, Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 8.001 X-RAY DIFFRACTION 0.369 0.359 False True unknown IGKV1 Kappa None None None None None 4u6v H L 0 A protein alpha-hemolysin IMMUNE SYSTEM 07/29/14 Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS TCH60 homo sapiens homo sapiens staphylococcus aureus subsp. aureus tch60 Oganesyan, V.Y., Peng, L., Damschroder, M.M., Cheng, L., Sadowska, A., Tkaczyk, C., Sellman, B., Wu, H., Dall'Acqua, W.F. 2.56 X-RAY DIFFRACTION 0.235 0.198 False True IGHV3 IGKV1 Kappa 1e-11 -15.006684983512798 SPR TBD 4lgp D NA 0 C protein NA ricin HYDROLASE/IMMUNE SYSTEM 06/28/13 Ricin A chain bound to camelid nanobody (VHH1) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Cheung, J., Franklin, M., Burshteyn, F., Cassidy, M., Gary, E., Mantis, N. 2.4 X-RAY DIFFRACTION 0.281 0.225 False True IGHV1 NA NA None None None None None 7swo H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 11/20/21 C98C7 Fab in complex with SARS-CoV-2 Spike 6P (RBD local reconstruction) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Windsor, I.W., Tong, P., Wesemann, D.R., Harrison, S.C. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7tzh C c 0 D protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 02/15/22 LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition HOMO SAPIENS homo sapiens homo sapiens Ming, Q., Tran, T.H., Luca, V.C. 2.43 X-RAY DIFFRACTION 0.255 0.212 True True unknown unknown unknown None None None None None 4rrp I C 0 O protein antigen asf1p IMMUNE SYSTEM 11/06/14 Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Kuzin, A., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Oconnell, P.T., Maglaqui, M., Bailey, L., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG) 2.79 X-RAY DIFFRACTION 0.253 0.183 False True IGHV3 IGKV1 Kappa None None None None None 2cmr H L 0 A protein transmembrane glycoprotein IMMUNE SYSTEM 05/11/06 Crystal structure of the HIV-1 neutralizing antibody D5 Fab bound to the gp41 inner-core mimetic 5-helix HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Luftig, M.A., Mattu, M., DiGiovine, P., Geleziunas, R., Hrin, R., Barbato, G., Bianchi, E., Miller, M.D., Pessi, A., Carfi, A. 2.0 X-RAY DIFFRACTION 0.258 0.209 False True IGHV1 IGKV1 Kappa 5.00e-11 -14.04 SPR 25 16862157 6uta A B 0 C protein env VIRAL PROTEIN 10/29/19 Crystal structure of Z004 iGL Fab in complex with ZIKV EDIII HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Esswein, S.R., Gristick, H.B., Keeffe, J.R., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.291 0.274 False True IGHV3 IGKV1 Kappa None None None None None 6x5b O M 0 J protein NA envelope glycoprotein gp120 VIRAL PROTEIN 05/25/20 Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7s11 K O 0 F protein NA t-cell surface protein tactile IMMUNE SYSTEM 08/31/21 Crystal structure of Fab in complex with mouse CD96 monomer MUS MUSCULUS; RATTUS rattus rattus mus musculus Lee, P.S., Chau, B., Strop, P. 2.58 X-RAY DIFFRACTION 0.279 0.226 False True IGHV2 IGLV1 Lambda None None None None None 5b8c B A 0 C protein programmed cell death protein 1 IMMUNE SYSTEM 06/14/16 High resolution structure of the human PD-1 in complex with pembrolizumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Horita, S., Shimamura, T., Iwata, S., Nomura, N. 2.146 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV3 Kappa None None None None None 4jzj H L 0 C protein interleukin-3 receptor subunit alpha CYTOKINE RECEPTOR/IMMUNE SYSTEM 04/03/13 Crystal Structure of Receptor-Fab Complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Broughton, S.E., Parker, M.W. 2.801 X-RAY DIFFRACTION 0.244 0.185 False False IGHV5 IGKV4 Kappa 4e-09 -11.456840020052727 SPR TBD 7e8c H L 0 A protein NA 368-2 h VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 5mu2 O P 0 W peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 7rsn H L 0 A protein NA amc018 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/11/21 AMC018 SOSIP.v4.2 in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.49 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6crq J L 0 F protein envelope glycoprotein gp160 VIRAL PROTEIN 03/19/18 Glutaraldehyde-treated BG505 SOSIP.664 Env in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Pallesen, J., Ward, A.B. 4.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 1dee B A 0 IMMUNE SYSTEM 11/15/99 CRYSTAL STRUCTURE AT 2.7A RESOLUTION OF A COMPLEX BETWEEN A STAPHYLOCOCCUS AUREUS DOMAIN AND A FAB FRAGMENT OF A HUMAN IGM ANTIBODY STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens Graille, M., Stura, E.A., Corper, A.L., Sutton, B.J., Taussig, M.J., Charbonnier, J.B., Silverman, G.J. 2.7 X-RAY DIFFRACTION 0.281 0.217 False False IGHV3 IGKV1 Kappa 4e-07 -8.728351841232218 Unknown TBD 7chy H L 0 I protein NA interleukin-1 beta IMMUNOSUPPRESSANT 07/06/20 Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, C.C., Wang, A.H.J., Kuo, W.C. 2.65 X-RAY DIFFRACTION 0.254 0.200 False True IGHV3 IGKV1 Kappa None None None None None 6ugs A B 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of PF06438179/GP1111 an infliximab biosimilar in a C-centered orthorhombic crystal form, Lot A HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H. 1.95 X-RAY DIFFRACTION 0.198 0.159 False True IGHV6 IGKV5 Kappa None None None None None 3t3p E F 0 C protein integrin alpha-iib CELL ADHESION 07/25/11 A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, J., Zhu, J., Springer, T.A. 2.2 X-RAY DIFFRACTION 0.220 0.189 False True IGHV14 IGKV14 Kappa None None None None None 6y1r D NA 0 NA NA NA NA IMMUNE SYSTEM 02/13/20 Nb22-LBT LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.85 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 NA NA None None None None None 6olp H L 0 F | E protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 Viral Protein/IMMUNE SYSTEM 04/16/19 Full length HIV-1 Env AMC011 in complex with PGT151 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Rantalainen, K., Cottrell, C.A. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 4xmm H L 0 D | C protein | protein NA | NA nucleoporin nup85 | nucleoporin seh1 Transport Protein/Immune System 01/14/15 Structure of the yeast coat nucleoporin complex, space group C2 SACCHAROMYCES CEREVISIAE S288C; HOMO SAPIENS homo sapiens homo sapiens saccharomyces cerevisiae s288c | saccharomyces cerevisiae s288c Stuwe, T., Correia, A.R., Lin, D.H., Paduch, M., Lu, V.T., Kossiakoff, A.A., Hoelz, A. 7.384 X-RAY DIFFRACTION 0.353 0.330 False True IGHV3 IGKV1D Kappa None None None None None 5grw A a 0 IMMUNE SYSTEM 08/12/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.8 X-RAY DIFFRACTION 0.182 0.182 True True unknown unknown unknown None None None None None 6okp Q R 0 F protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/14/19 B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.28 ELECTRON MICROSCOPY False True IGHV4 IGKV3 Kappa None None None None None 6o41 D C 0 IMMUNE SYSTEM 02/27/19 Crystal structure of the unbound PGZL1 germline Fab fragment (PGZL1_gVmDmJ) HOMO SAPIENS; STREPTOCOCCUS SP. GROUP G homo sapiens homo sapiens Irimia, A., Wilson, I.A. 2.465 X-RAY DIFFRACTION 0.219 0.169 False True IGHV1 IGKV3 Kappa None None None None None 5f6h I J 0 IMMUNE SYSTEM 12/06/15 Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.66 X-RAY DIFFRACTION 0.262 0.230 False True IGHV3 IGLV2 Lambda None None None None None 1bj1 H L 0 W protein vascular endothelial growth factor COMPLEX (ANTIBODY/ANTIGEN) 06/30/98 VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Muller, Y.A., Christinger, H.W., De Vos, A.M. 2.4 X-RAY DIFFRACTION 0.266 0.196 False True IGHV7 IGKV1 Kappa 3.40e-09 -11.55 SPR 25 9753694 4tnw F N 0 B protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False IGHV1 IGLV1 Lambda None None None None None 3bqu D C 0 IMMUNE SYSTEM 12/20/07 Crystal Structure of the 2F5 Fab'-3H6 Fab Complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus Bryson, S., Julien, J.-P., Isenman, D.E., Kunert, R., Katinger, H., Pai, E.F. 3.0 X-RAY DIFFRACTION 0.295 0.276 False False IGHV1 IGKV17 Kappa None None None None None 5h8o A NA 0 B protein apoptosis-associated speck-like protein containing a card IMMUNE SYSTEM 12/23/15 Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Lu, A., Schmidt, F.I., Ruan, J., Tang, C., Wu, H., Ploegh, H.L. 4.206 X-RAY DIFFRACTION 0.356 0.300 False True IGHV1 None None None None None 7v3h G H 0 A protein NA envelope protein e VIRUS/IMMUNE SYSTEM 08/10/21 DENV2_NGC_Fab_C10 28degrees (3Fab:3E) DENGUE VIRUS TYPE 2 (STRAIN THAILAND/NGS-C/1944); HOMO SAPIENS homo sapiens homo sapiens dengue virus type 2 (strain thailand/ngs-c/1944) Shu, B., Zhang, S., Victor, A.K., Ng, T.S., Lok, S.M. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 3j7e B A 0 IMMUNE SYSTEM 06/23/14 Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments MUS MUSCULUS mus musculus mus musculus Lee, H., Brendle, S.A., Bywaters, S.M., Christensen, N.D., Hafenstein, S. 13.6 ELECTRON MICROSCOPY False False IGHV1 IGKV8 Kappa None None None None None 5vl2 C NA 0 C Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 5t1l B A 0 IMMUNE SYSTEM 08/19/16 Cetuximab Fab in complex with CQA(Ph)2DLSTRRLKC peptide MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.204 0.158 False True IGHV2 IGKV5 Kappa 2.4e-07 -9.031007686639388 Unknown TBD 3nfp A B 0 K protein interleukin-2 receptor subunit alpha Immune system/Cytokine 06/10/10 Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J. 2.86 X-RAY DIFFRACTION 0.301 0.253 False True IGHV1 IGKV1 Kappa 2.70e-10 -13.05 SPR 25 20820193 2a6k B A 0 IMMUNE SYSTEM 07/03/05 Crystal Structure Analysis of the germline antibody 36-65 Fab in complex with the dodecapeptide SLGDNLTNHNLR MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M. 3.0 X-RAY DIFFRACTION 0.264 0.245 False False IGHV1 IGKV10 Kappa 2.0999999999999997e-07 -9.11012285753709 Unknown TBD 1za6 F E 0 IMMUNE SYSTEM 04/05/05 The structure of an antitumor CH2-domain-deleted humanized antibody HOMO SAPIENS homo sapiens homo sapiens Larson, S.B., Day, J.S., Glaser, S., Braslawsky, G., McPherson, A. 2.8 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV4 Kappa None None None None None 5j57 B NA 0 A protein ricin HYDROLASE/IMMUNE SYSTEM 04/01/16 V5E1-RTA complex RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.7 X-RAY DIFFRACTION 0.190 0.163 False True IGHV1 2.0000000000000002e-11 -14.596006591193015 SPR TBD 7dm2 H L 0 A protein NA phosphate-binding protein psts 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 12/01/20 crystal structure of the M. tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-170 MYCOBACTERIUM TUBERCULOSIS H37RV; HOMO SAPIENS homo sapiens homo sapiens mycobacterium tuberculosis h37rv Ma, B., Freund, N., Xiang, Y. 2.4 X-RAY DIFFRACTION 0.216 0.170 False True IGHV3 IGLV1 Lambda None None None None None 5bk3 C D 0 D carbohydrate NAG polysaccharide IMMUNE SYSTEM 09/12/17 Crystal structure of the neutralizing anti-circumsporozoite protein 580 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 2.8 X-RAY DIFFRACTION 0.231 0.190 False True IGHV3 IGKV4 Kappa None None None None None 6itp A NA 0 A Hapten HCY (11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE IMMUNE SYSTEM 11/24/18 Crystal structure of cortisol complexed with its nanobody at pH 3.5 CAMELUS BACTRIANUS camelus bactrianus camelus bactrianus Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. 1.572 X-RAY DIFFRACTION 0.223 0.195 False True unknown unknown unknown None None None None None 7dur N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 BIOSYNTHETIC PROTEIN 01/11/21 Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Cong, Z., Chen, L., Ma, H., Zhou, Q., Zou, X., Ye, C., Dai, A., Liu, Q., Huang, W., Sun, X., Wang, X., Xu, P., Zhao, L., Xia, T., Zhong, W., Yang, D., Xu, H.E., Zhang, Y., Wang, M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6ukt F NA 0 B protein guanine nucleotide-binding protein g(i) subunit alpha-1 SIGNALING PROTEIN 10/05/19 Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., Zhang, K., Johnston, J.D., Chiu, W., Sprang, S.R. 3.87 ELECTRON MICROSCOPY False True IGHV1 None None None None None 7d77 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/03/20 Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ping, Y., Mao, C., Xiao, P., Zhao, R., Jiang, Y., Yang, Z., An, W., Shen, D., Yang, F., Zhang, H., Qu, C., Shen, Q., Tian, C., Li, Z., Li, S., Wang, G., Tao, X., Wen, X., Zhong, Y., Yang, J., Yi, F., Yu, X., Xu, E., Zhang, Y., Sun, J. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2bx5 NA I 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 7kml I M 0 B protein NA spike glycoprotein Viral protein/Immune System 11/03/20 cryo-EM structure of SARS-CoV-2 spike in complex with Fab 15033-7, three RBDs bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5dum H L 0 A protein hemagglutinin IMMUNE SYSTEM 09/19/15 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 65C6 HOMO SAPIENS; INFLUENZA A VIRUS (A/ANHUI/1/2005(H5N1)) homo sapiens homo sapiens influenza a virus (a/anhui/1/2005(h5n1)) Sun, J., Zuo, T., Wang, G., Zhou, P., Zhang, L., Wang, X. 3.003 X-RAY DIFFRACTION 0.269 0.215 False True IGHV5 IGKV3 Kappa None None None None None 7bsd H L 0 I protein NA ns1c IMMUNE SYSTEM/VIRAL PROTEIN 03/30/20 Complex structure of 1G5.3 Fab bound to ZIKV NS1c HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Song, H., Qi, J., Gao, F.G. 2.53 X-RAY DIFFRACTION 0.239 0.221 False True IGHV3 IGKV3 Kappa None None None None None 7ps2 A B 0 G protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-29 and Beta-53 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.99 X-RAY DIFFRACTION 0.266 0.233 False True IGHV3 IGKV4 Kappa None None None None None 1mcb NA B 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS; SYNTHETIC CONSTRUCT phoca vitulina Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 4ubd C D 0 B | I protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 08/12/14 Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Shore, D.A., Yang, H., Cho, M., Donis, R.O., Stevens, J. 3.5 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 IGKV3 Kappa None None None None None 6orn A B 0 G protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.05 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 6mco D E 0 B protein transmembrane protein gp41 VIRAL PROTEIN 08/31/18 Crystal structure of the B41 SOSIP.664 Env trimer with PGT124 and 35O22 Fabs, in P23 space group HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Sarkar, A., Wilson, I.A. 3.526 X-RAY DIFFRACTION 0.322 0.306 False True unknown unknown unknown None None None None None 6sc8 B NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-Ligand4 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.106 X-RAY DIFFRACTION 0.261 0.219 False True IGHV3 None None None None None 7zf8 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron BA.2 RBD in complex with COVOX-150 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 2.95 X-RAY DIFFRACTION 0.258 0.220 False True IGHV3 IGKV1 Kappa None None None None None 4xcy J K 0 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidylglycerol (06:0 PG) HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 3.96 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 IGKV3 Kappa None None None None None 7e86 A B 0 C protein NA spike protein s1 VIRAL PROTEIN,IMMUNE SYSTEM 03/01/21 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-508 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, C., Xiao, J. 2.9 X-RAY DIFFRACTION 0.255 0.196 False True IGHV3 IGKV1 Kappa None None None None None 2qtj D O 0 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5w1k D C 0 E protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV4 IGKV3 Kappa None None None None None 1rih H L 0 IMMUNE SYSTEM 11/17/03 Crystal Structure of Fab 14F7, a unique anti-tumor antibody specific for N-glycolyl GM3 MUS MUSCULUS mus musculus mus musculus Krengel, U., Olsson, L.-L., Martinez, C., Talavera, A., Rojas, G., Mier, E., Angstrom, J., Moreno, E. 2.5 X-RAY DIFFRACTION 0.238 0.181 False False IGHV1 IGKV5 Kappa None None None None None 3ztj G H 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/VIRAL PROTEIN 07/08/11 Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin. HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Voss, J.E., Vachieri, S.G., Gamblin, S.J., Collins, P.J., Haire, L.F., Skehel, J.J. 3.41 X-RAY DIFFRACTION 0.28434 0.23410 False True IGHV3 IGKV4 Kappa None None None None None 1mcq NA A 0 P peptide peptide n-acetyl-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 3stb B NA 0 C protein rna-editing complex protein mp42 RNA BINDING PROTEIN/IMMUNE SYSTEM 07/09/11 A complex of two editosome proteins and two nanobodies LAMA GLAMA; TRYPANOSOMA BRUCEI lama trypanosoma brucei Park, Y.-J., Hol, W. 2.5 X-RAY DIFFRACTION 0.234 0.199 False True IGHV1 None None None None None 6oao D d 0 C protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 092096 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 3.497 X-RAY DIFFRACTION 0.279 0.238 True True unknown unknown unknown None None None None None 5mwn D NA 0 B protein type vi secretion protein TRANSPORT PROTEIN 01/18/17 Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 LAMA GLAMA; ESCHERICHIA COLI lama glama escherichia coli Cambillau, C., Nguyen, V.S., Spinelli, S., Legrand, P. 2.2 X-RAY DIFFRACTION 0.220 0.199 False True IGHV1 None None None None None 1fve B A 0 IMMUNOGLOBULIN 10/20/92 X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Randal, M., Presta, L., Kossiakoff, A.A. 2.7 X-RAY DIFFRACTION unknown 0.171 False True IGHV3 IGKV1 Kappa None None None None None 4zg1 D NA 0 PROTEIN BINDING 04/22/15 Crystal structure of a nanobody raised against KDM5b LAMA GLAMA lama glama Wiuf, A., Kristensen, O., Gajhede, M. 1.85 X-RAY DIFFRACTION 0.235 0.186 False True IGHV1 None None None None None 7rd3 H L 0 D peptide NA circumsporozoite protein IMMUNE SYSTEM 07/09/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.126 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 1.81 X-RAY DIFFRACTION 0.260 0.216 False True IGHV1 IGKV4 Kappa None None None None None 5xp1 NA H 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 6z43 Z NA 0 C protein spike glycoprotein VIRAL PROTEIN 06/03/20 Cryo-EM Structure of SARS-CoV-2 Spike : H11-D4 Nanobody Complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Ruza, R.R., Duyvesteyn, H.M.E., Shah, P., Carrique, L., Ren, J., Malinauskas, T., Zhou, D., Stuart, D.I., Naismith, J.H. 3.3 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6iyn A NA 4 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 1mhh D C 0 IMMUNE SYSTEM 08/20/02 Antibody-antigen complex FINEGOLDIA MAGNA; MUS MUSCULUS mus musculus mus musculus Graille, M., Stura, E.A. 2.1 X-RAY DIFFRACTION 0.247 0.197 False False IGHV9 IGKV8 Kappa 1e-09 -12.27819680469229 Unknown TBD 5w3e E G 0 B | A | C protein | protein | protein NA | NA | NA viral protein 3 | viral protein 1 | viral protein 2 VIRUS/IMMUNE SYSTEM 06/07/17 CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:3, full particle) MUS MUSCULUS; HUMAN RHINOVIRUS 14 mus musculus mus musculus human rhinovirus 14 | human rhinovirus 14 | human rhinovirus 14 Liu, Y., Dong, Y., Rossmann, M.G. 2.53 ELECTRON MICROSCOPY False False IGHV2 IGKV12 Kappa None None None None None 6raf C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB in inward-facing narrow conformation under turnover conditions THERMUS THERMOPHILUS HB27; THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 3.8 ELECTRON MICROSCOPY False True IGHV1 None None None None None 5vl3 E F 0 T protein b-cell receptor cd22 IMMUNE SYSTEM 04/24/17 CD22 d1-d3 in complex with therapeutic Fab Epratuzumab HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Sicard, T., Ereno-Orbea, J., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.295 0.280 False True IGHV1 IGKV8 Kappa None None None None None 5uqy D C 0 A protein NA envelope glycoprotein gp1 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/17 Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 LAKE VICTORIA MARBURGVIRUS (STRAIN RAVN-87); HOMO SAPIENS homo sapiens homo sapiens lake victoria marburgvirus (strain ravn-87) Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O. 3.6 X-RAY DIFFRACTION 0.262 0.221 False False IGHV4 IGKV1 Kappa None None None None None 7lf8 H L 0 A protein NA apolipoprotein l2 IMMUNE SYSTEM 01/15/21 Fab 6D12 bound to ApoL2 NTD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Kirchhofer, D. 2.15 X-RAY DIFFRACTION 0.230 0.192 False True IGHV5 IGKV16 Kappa None None None None None 6rlm I J 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 6b3d H L 0 H carbohydrate MAN polysaccharide IMMUNE SYSTEM 09/21/17 Crystal structure of anti-HIV antibody PGT128 in complex with a bacterially derived synthetic mimetic of Man9. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murrell, S., Wilson, I.A. 2.271 X-RAY DIFFRACTION 0.198 0.163 False True unknown IGLV2 Lambda None None None None None 4rbp H L 0 H carbohydrate KDO polysaccharide IMMUNE SYSTEM 09/12/14 Crystal structure of HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomanose HOMO SAPIENS homo sapiens homo sapiens homo sapiens Stanfield, R.L., Wilson, I.A., De Castro, C., Marzaioli, A.M., Pantophlet, R. 1.85 X-RAY DIFFRACTION 0.252 0.208 False False IGHV3 IGKV1 Kappa None None None None None 7qn8 K NA 0 B protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25 HOMO SAPIENS homo sapiens homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6wpt H L 0 C protein sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/27/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment (open state) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., De Marco, A., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.7 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6lxk H L 0 A protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of Z2B3 D102R Fab in complex with influenza virus neuraminidase from A/Serbia/NS-601/2014 (H1N1) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 3.608 X-RAY DIFFRACTION 0.249 0.215 False True IGHV1 IGLV2 Lambda None None None None None 6iek B C 0 A protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R12 RIFT VALLEY FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 2.7 X-RAY DIFFRACTION 0.258 0.225 False True IGHV1 IGLV5 Lambda None None None None None 2aj3 F E 0 IMMUNE SYSTEM 08/01/05 Crystal Structure of a Cross-Reactive HIV-1 Neutralizing CD4-Binding Site Antibody Fab m18 HOMO SAPIENS homo sapiens homo sapiens Prabakaran, P., Gan, J., Wu, Y.Q., Zhang, M.Y., Dimitrov, D.S., Ji, X. 2.03 X-RAY DIFFRACTION 0.269 0.225 False True IGHV4 IGKV1 Kappa None None None None None 7cea A B 0 NA NA NA NA IMMUNE SYSTEM 06/22/20 Crystal structure of HUTS-4 Fv-clasp fragment MUS MUSCULUS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Arimori, T., Takagi, J. 2.55 X-RAY DIFFRACTION 0.266 0.252 False True IGHV8 IGKV4 Kappa None None None None None 2kh2 B b 7 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5uk4 a NA 0 A protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 4k3h NA E 0 E Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 1g9e A NA 10 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6mui C D 0 B protein NA e2 VIRUS/IMMUNE SYSTEM 10/23/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-42 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.7 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 6ikm R r 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 7l7e T U 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV1 IGKV3 Kappa None None None None None 6mtj H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/19/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies 3H109L and 35O22 at 2.9 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.336 X-RAY DIFFRACTION 0.282 0.233 False True IGHV4 unknown unknown None None None None None 7a4d D NA 0 F peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 6ymq F f 0 K protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 04/09/20 TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Scacioc, A., Mukhopadhyay, S.M.M., McKinley, G., Graslund, S., Wigren, E., Persson, H., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Di Daniel, E., Davis, J.B., Burgess-Brown, N., Bullock, A. 3.07 X-RAY DIFFRACTION 0.288 0.274 True True unknown unknown unknown None None None None None 3e8u H L 0 P peptide bnp peptide epitope IMMUNE SYSTEM 08/20/08 Crystal structure and thermodynamic analysis of diagnostic Fab 106.3 complexed with BNP 5-13 (C10A) reveal basis of selective molecular recognition MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Longenecker, K.L., Ruan, Q., Fry, E.H., Saldana, S.S., Brophy, S.E., Richardson, P.L., Tetin, S.Y. 2.1 X-RAY DIFFRACTION 0.243 0.185 False True IGHV9 IGKV3 Kappa 2.00e-10 -13.14 Other 23 19274732 6pwu H L 0 A | C | E protein | protein | protein NA | NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN 07/23/19 Structure of full-length, fully glycosylated, non-modified HIV-1 gp160 bound to PG16 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Pan, J., Chen, B., Harrison, S.C. 6.2 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 7c6a H L 0 A protein NA type-2 angiotensin ii receptor,soluble cytochrome b562,type-2 angiotensin ii receptor SIGNALING PROTEIN 05/21/20 Crystal structure of AT2R-BRIL and SRP2070_Fab complex MUS MUSCULUS; HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens, escherichia coli Suzuki, M., Miyagi, H., Asada, H., Yasunaga, M., Suno, C., Takahashi, Y., Saito, J., Iwata, S. 3.4 X-RAY DIFFRACTION 0.285 0.235 False True IGHV1 IGKV5 Kappa None None None None None 7kej H K 0 B protein NA virion spike glycoprotein VIRAL PROTEIN/Immune System 10/11/20 BDBV-289 bound to EBOV GPdMuc Makona EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 6nfc C D 0 I | E protein | protein NA | NA hiv-1 env bg505 md64 n332-gt5 sosip gp41 | hiv-1 env bg505 md64 n332-gt5 sosip gp120 VIRAL PROTEIN 12/19/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7k3b L K 0 E | F protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation C, central helices splay INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7l56 J K 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-43 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7ral H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/01/21 SARS-CoV-2 S bound to S2X259 Fab (local refinement of the RBD/S2X259 variable domains) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Veesler, D., Tortorici, M.A., Seattle Structural Genomics Center for Infectious Disease (SSGCID) NOT ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7k8u H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Barnes, C.O., Malyutin, A.G., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4rrp J D 0 P protein antigen asf1p IMMUNE SYSTEM 11/06/14 Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Kuzin, A., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Oconnell, P.T., Maglaqui, M., Bailey, L., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG) 2.79 X-RAY DIFFRACTION 0.253 0.183 False True IGHV3 IGKV1 Kappa None None None None None 3cm9 A L 6 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7eh3 A NA 4 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 4idj H L 0 A protein alpha-hemolysin IMMUNE SYSTEM 12/12/12 S.Aureus a-hemolysin monomer in complex with Fab STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus Strop, P. 3.36 X-RAY DIFFRACTION 0.296 0.249 False True IGHV1 IGKV3 Kappa 1.6999999999999998e-12 -16.056540494021775 Unknown TBD 6hxw C D 0 B protein 5'-nucleotidase IMMUNE SYSTEM 10/18/18 structure of human CD73 in complex with antibody IPH53 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Roussel, A., Amigues, B. 2.78 X-RAY DIFFRACTION 0.232 0.192 False True IGHV1 IGKV1 Kappa None None None None None 1bvl A B 0 HUMANIZED ANTIBODY 09/16/98 HUMANIZED ANTI-LYSOZYME FV HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Holmes, M.A., Foote, J. 2.87 X-RAY DIFFRACTION unknown 0.220 False True IGHV4 IGKV1 Kappa None None None None None 7bue J K 0 C protein dengue serotype 2 e protein ectodomain VIRUS 05/13/20 Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 7.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7rlv E F 0 Q peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRADGQPAGDRADGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.220 0.179 False True IGHV1 IGKV1 Kappa None None None None None 2brr H L 0 P peptide class 1 outer membrane protein variable region 2 IMMUNE SYSTEM 05/11/05 Complex of the neisserial PorA P1.4 epitope peptide and two Fab- fragments (antibody MN20B9.34) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Oomen, C.J., Hoogerhout, P., Kuipers, B., Vidarsson, G., vanAlphen, L., Gros, P. 1.95 X-RAY DIFFRACTION 0.238 0.198 False True IGHV9 IGKV4 Kappa None None None None None 5a2j H h 0 P peptide the naked peptide apdtrp PEPTIDE BINDING PROTEIN 05/20/15 Crystal structure of scFv-SM3 in complex with the naked peptide APDTRP MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Martinez-Saez, N., Castro-Lopez, J., Valero-Gonzalez, J., Madariaga, D., Companon, I., Somovilla, V.J., Salvado, M., Asensio, J.L., Jimenez-Barbero, J., Avenoza, A., Busto, J.H., Bernardes, G.J.L., Peregrina, J.M., Hurtado-Guerrero, R., Corzana, F. 1.65 X-RAY DIFFRACTION 0.19733 0.16643 True True unknown unknown unknown 1.4e-06 -7.986110227490359 Unknown TBD 4aj0 NA A 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rCW, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.7 X-RAY DIFFRACTION 0.2116 0.1741 False True IGLV3 Lambda None None None None None 7czv H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B6_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6q1z H L 0 A protein neuraminidase VIRAL PROTEIN,HYDROLASE/IMMUNE SYSTEM 08/06/19 Crystal structure of human 1G04 Fab in complex with influenza virus neuraminidase from A/Hunan/02650/2016 (H7N9) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 3.446 X-RAY DIFFRACTION 0.247 0.197 False True IGHV3 IGKV1 Kappa None None None None None 7kbm A a 0 NA NA NA NA PROTEIN BINDING 10/02/20 Reverse Transcriptase Diabody with R83C Mutation Crystallized in C2 HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 2.0 X-RAY DIFFRACTION 0.257 0.209 True True unknown unknown unknown None None None None None 4rnr C D 0 D carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/24/14 Crystal structure of broadly neutralizing anti-HIV antibody PGT130 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.758 X-RAY DIFFRACTION 0.269 0.244 False True IGHV4 IGLV2 Lambda None None None None None 3zdx E F 0 C protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.45 X-RAY DIFFRACTION 0.1971 0.1628 False True IGHV14 IGKV14 Kappa None None None None None 1xf2 B A 0 IMMUNE SYSTEM/DNA 09/13/04 Structure of Fab DNA-1 complexed with dT3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J. 2.3 X-RAY DIFFRACTION 0.242 0.202 False True IGHV1 IGKV12 Kappa None None None None None 6umx H L 0 A protein growth/differentiation factor 8 SIGNALING PROTEIN/IMMUNE SYSTEM 10/10/19 Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Dagbay, K.B., Treece, E., Streich Jr., F.C., Jackson, J.W., Faucette, R.R., Nikiforov, A., Lin, S.C., Bostion, C.J., Nicholls, S.B., Capili, A.D., Carven, G.J. 2.79 X-RAY DIFFRACTION 0.264 0.217 False True IGHV3 IGLV1 Lambda None None None None None 6pv8 F G 0 D | E protein | protein NA | NA fusion protein of neuronal acetylcholine receptor subunitalpha-3 and soluble cytochrome b562 | fusion protein of neuronal acetylcholine receptor subunitbeta-4 and soluble cytochrome b562 MEMBRANE PROTEIN 07/19/19 Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001 HOMO SAPIENS; ESCHERICHIA COLI O11; MUS MUSCULUS mus musculus mus musculus homo sapiens, escherichia coli o11 | homo sapiens, escherichia coli o11 Gharpure, A., Teng, J., Zhuang, Y., Noviello, C.M., Walsh, R.M., Cabuco, R., Howard, R.J., Zaveri, N.T., Lindahl, E., Hibbs, R.E. 3.87 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 7qn8 M NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25 HOMO SAPIENS homo sapiens homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7wec H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein with three XGv347 Fabs binding to three closed state RBDs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6oyh G NA 0 C protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/14/19 Crystal structure of MraY bound to carbacaprazamycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 2.95 X-RAY DIFFRACTION 0.268 0.249 False True IGHV1 None None None None None 5vl7 H L 0 B protein proprotein convertase subtilisin/kexin type 9 HYDROLASE 04/25/17 PCSK9 complex with Fab33 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Shia, S. 3.5 X-RAY DIFFRACTION 0.245 0.199 False True IGHV3 IGKV1 Kappa None None None None None 6xw6 D NA 0 B protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5853 MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 1.96 X-RAY DIFFRACTION 0.248 0.199 False True IGHV1 None None None None None 7ul5 D NA 0 A protein NA somatostatin receptor type 2 MEMBRANE PROTEIN 04/03/22 CryoEM Structure of Inactive SSTR2 bound to Nb6 Homo sapiens; Lama glama lama glama homo sapiens Robertson, M.J., Skiniotis, G. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7q6c H L 0 A protein NA complement component c6 IMMUNE SYSTEM 11/06/21 complement C6 FIM1-2 bound to CP010 antibody HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA mus musculus mus musculus homo sapiens Olesen, H.G., Andersen, G.R. 2.29274 X-RAY DIFFRACTION 0.233 0.208 False True IGHV5 IGKV2 Kappa None None None None None 7dkj C D 0 A protein NA hemagglutinin VIRAL PROTEIN 11/24/20 Hemagglutinin Influenza A virus (A/Okuda/1957(H2N2) bound with a neutralizing antibody INFLUENZA A VIRUS (A/OKUDA/1957(H2N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/okuda/1957(h2n2)) Kamada, K., Shirouzu, M. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV12 Kappa None None None None None 7czr H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B8_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2kh2 B b 23 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6eyn D C 0 IMMUNE SYSTEM 11/13/17 Structure of the 8D6 (anti-IgE) Fab HOMO SAPIENS homo sapiens homo sapiens Chen, J.B., Ramadani, F., Pang, M.O.Y., Beavil, R.L., Holdom, M.D., Mitropoulou, A.N., Beavil, A.J., Gould, H.J., Chang, T.W., Sutton, B.J., McDonnell, J.M., Davies, A.M. 2.4 X-RAY DIFFRACTION 0.212 0.181 False True IGHV1 IGKV3 Kappa None None None None None 6fxn F G 0 B protein tumor necrosis factor ligand superfamily member 13b IMMUNE SYSTEM 03/09/18 Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lammens, A., Maskos, K., Willen, L., Jiang, X., Schneider, P. 2.9 X-RAY DIFFRACTION 0.231 0.191 False True IGHV1 IGLV3 Lambda None None None None None 5xqw H L 0 H Hapten 8EU ethyl-[(4-nitrophenyl)methoxy]phosphinic acid IMMUNE SYSTEM 06/07/17 Catalytic antibody 7B9 MUS MUSCULUS mus musculus mus musculus mus musculus Ito, N., Fujii, I., Tsumuraya, T. 2.2 X-RAY DIFFRACTION 0.261 0.187 False True IGHV1 IGKV14 Kappa None None None None None 6oik H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/09/19 Muscarinic acetylcholine receptor 2-Go complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Maeda, S., Qianhui, Q., Skiniotis, G., Kobilka, B. 3.6 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6xlq B C 0 A protein NA butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 06/29/20 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the CTX-2026 Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payne, K.K., Mine, J.A., Biswas, S., Chaurio, R.A., Perales-Puchalt, A., Anadon, C.M., Costich, T.L., Harro, C.M., Walrath, J., Ming, Q., Tcyganov, E., Buras, A.L., Rigolizzo, K.E., Mandal, G., Lajoie, J., Ophir, M., Tchou, J., Marchion, D., Luca, V.C., Bobrowicz, P., McLaughlin, B., Eskiocak, U., Schmidt, M., Cubillos-Ruiz, J.R., Rodriguez, P.C., Gabrilovich, D.I., Conejo-Garcia, J.R. 3.0 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV1 Kappa None None None None None 4qgy A NA 0 IMMUNE SYSTEM 05/26/14 Camelid (llama) nanobody n25 (VHH) against type 6 secretion system TssM protein LAMA GLAMA lama glama Nguyen, V.S., Desmyter, A., Le, T.T.H., Durand, E., Kellenberger, C., Douzi, B., Spinelli, S., Cascales, E., Cambillau, C., Roussel, A. 1.38 X-RAY DIFFRACTION 0.198 0.191 False True IGHV1 None None None None None 2y5t A B 0 E | G | F peptide | peptide | peptide NA | NA | NA c1 | c1 | c1 IMMUNE SYSTEM 01/17/11 Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus | mus musculus | mus musculus Dobritzsch, D., Lindh, I., Schneider, N., Uysal, H., Nandakumar, K.S., Burkhardt, H., Schneider, G., Holmdahl, R. 2.2 X-RAY DIFFRACTION 0.24544 0.18845 False False IGHV1 IGKV3 Kappa None None None None None 7nll A NA 0 D protein NA surface glycoprotein VIRAL PROTEIN 02/22/21 SARS-CoV-2 Spike RBD (dimer) in complex with two Fu2 nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Das, H., Hallberg, B.M. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ra3 E e 0 A protein NA guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short MEMBRANE PROTEIN 06/29/21 cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT mus musculus homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.24 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4yga H NA 0 G protein calmodulin-domain protein kinase 1 METAL BINDING PROTEIN 02/26/15 CDPK1, from Toxoplasma gondii, bound to inhibitory VHH-1B7 VICUGNA PACOS; TOXOPLASMA GONDII vicugna pacos toxoplasma gondii Knockenhauer, K.E., Schwartz, T.U. 2.94 X-RAY DIFFRACTION 0.262 0.226 False True IGHV1 None None None None None 6cxy H L 0 C protein NA cadherin-1 CELL ADHESION 04/04/18 Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.2 X-RAY DIFFRACTION 0.197 0.163 False True IGHV2 IGKV8 Kappa None None None None None 4zyp K M 0 A protein fusion glycoprotein f0,fibritin IMMUNE SYSTEM 05/21/15 Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS mus musculus mus musculus human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 5.5 X-RAY DIFFRACTION 0.277 0.211 False True IGHV2 IGKV1 Kappa None None None None None 5kaq H L 0 B protein hemagglutinin IMMUNE SYSTEM 06/01/16 Crystal structure of broadly neutralizing Influenza A antibody 31.a.83 in complex with Hemagglutinin Hong Kong 1968. INFLUENZA A VIRUS (A/HONG KONG/1-4-MA21-1/1968(H3N2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 3.514 X-RAY DIFFRACTION 0.313 0.270 False True IGHV3 IGKV3 Kappa None None None None None 5w9n E F 0 D protein mers s VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 5 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 3kr3 H L 0 D protein insulin-like growth factor ii IMMUNE SYSTEM 11/17/09 Crystal structure of IGF-II antibody complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Peat, T.S., Newman, J., Adams, T.E. 2.2 X-RAY DIFFRACTION 0.251 0.199 False True IGHV3 IGKV1 Kappa 4.90e-11 -14.06 SPR 25 20515953 5t5b A B 0 O protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 08/30/16 CRYSTAL STRUCTURE OF THE COMPLEX OF 10E8 FAB LIGHT CHAIN MUTANT5 AND T117V2 HIV-1 MPER SCAFFOLD SYNTHETIC CONSTRUCT; HOMO SAPIENS homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.07 X-RAY DIFFRACTION 0.216 0.178 False True IGHV3 IGLV3 Lambda 1.2300000000000001e-10 -13.519788377213574 SPR TBD 3p30 H L 0 A protein hiv-1 gp41 IMMUNE SYSTEM 10/04/10 crystal structure of the cluster II Fab 1281 in complex with HIV-1 gp41 ectodomain HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Frey, G., Chen, J., Rits-Volloch, S., Freeman, M.M., Zolla-Pazner, S., Chen, B. 3.3 X-RAY DIFFRACTION 0.289 0.261 False True IGHV1 IGLV1 Lambda None None None None None 7e3l D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/09/21 Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Li, T., Liu, F., Gao, Y., Ji, X., Yang, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4xaw H L 0 P peptide fragment of hiv glycoprotein (gp41) including the mperregion 671-683 IMMUNE SYSTEM 12/15/14 Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41: Crystals cryoprotected with phosphatidic acid (08:0 PA) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Stanfield, R.L., Wilson, I.A. 1.47 X-RAY DIFFRACTION 0.181 0.148 False True IGHV1 IGKV3 Kappa None None None None None 7tcc D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 6orp D E 0 B protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 6c6x H L 0 IMMUNE SYSTEM 01/19/18 Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque. MACACA MULATTA macaca mulatta macaca mulatta Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.208 0.176 False True IGHV4 IGKV1 Kappa None None None None None 3hmx H L 0 A protein interleukin-12 subunit beta Cytokine/IMMUNE SYSTEM 05/29/09 Crystal structure of ustekinumab FAB/IL-12 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J. 3.0 X-RAY DIFFRACTION 0.303 0.211 False True IGHV5 IGKV1D Kappa None None None None None 2ig2 H L 0 IMMUNOGLOBULIN 04/18/89 DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L-KETTE, LAMBDA-TYP, SUBGRUPPE I (GERMAN) HOMO SAPIENS homo sapiens homo sapiens Marquart, M., Huber, R. 3.0 X-RAY DIFFRACTION unknown 0.207 False True IGHV3 IGLV1 Lambda None None None None None 7qic B NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/14/21 Structure of magnesium-bound EleNRMT in complex with two nanobodies at 4.1A EGGERTHELLA LENTA; SYNTHETIC CONSTRUCT synthetic construct eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ljr S T 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/30/21 SARS-CoV-2 Spike Protein Trimer bound to DH1043 fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gobeil, S., Acharya, P. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5uk1 H h 0 C protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 3 HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); INFLUENZA A VIRUS homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 5vm4 J NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 6awn B C 0 A protein NA sodium-dependent serotonin transporter TRANSPORT PROTEIN 09/06/17 X-ray structure of the S439T human serotonin transporter complexed with paroxetine at the central site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Gouaux, E. 3.62 X-RAY DIFFRACTION 0.263 0.256 False True IGHV1 IGKV6 Kappa None None None None None 6b3s F G 0 E protein epidermal growth factor receptor TRANSFERASE/immune system 09/23/17 Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Bagchi, A. 2.8 X-RAY DIFFRACTION 0.245 0.208 False True IGHV4 IGKV3 Kappa 1.2000000000000002e-08 -10.805930168369423 SPR TBD 6btj A B 0 NA NA NA NA ANTIVIRAL PROTEIN 12/06/17 Crystal structure of pan-H7, anti-hemagglutinin monoclonal antibody H7.5 (Fab fragment) HOMO SAPIENS homo sapiens homo sapiens Shanshan, L., Ian, A.W. 1.999 X-RAY DIFFRACTION 0.201 0.200 False True IGHV1 IGKV1 Kappa None None None None None 7rkv D H 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C118 (State 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Jette, C.A., Bjorkman, P.J. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 3bn9 D C 0 B protein membrane-type serine protease 1 HYDROLASE 12/13/07 Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Farady, C.J., Schneider, E.L., Egea, P.F., Goetz, D.H., Craik, C.S. 2.173 X-RAY DIFFRACTION 0.267 0.223 False True IGHV3 IGKV1 Kappa None None None None None 6v8z C F 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 2.9 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 5gkr A B 0 T nucleic-acid dna (5'-d(p*tp*tp*tp*t)-3') IMMUNE SYSTEM/DNA 07/05/16 Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Arimori, T., Sakakibara, S., Kikutani, H., Takagi, J. 2.1 X-RAY DIFFRACTION 0.185 0.163 False True IGHV4 IGLV2 Lambda 4.6100000000000004e-09 -11.372746740093346 Unknown TBD 5tqq I M 0 B protein chloride channel protein TRANSPORT PROTEIN 10/24/16 Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation MUS MUSCULUS; BOS TAURUS mus musculus mus musculus bos taurus Park, E., MacKinnon, R. 3.76 ELECTRON MICROSCOPY False True IGHV3 IGKV6 Kappa None None None None None 2jb6 H L 0 H Hapten T5C 2-{(1E,3Z,5E,7E)-7-[3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-1,3-DIHYDRO-2H-INDOL-2-YLIDENE]-4-METHYLHEPTA-1,3,5-TRIEN-1-YL}-3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-3H-INDOLIUM IMMUNE SYSTEM 12/03/06 Fab fragment in complex with small molecule hapten, crystal form-2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hillig, R.C., Baesler, S., Malawski, G., Badock, V., Bahr, I., Schirner, M., Licha, K. 2.85 X-RAY DIFFRACTION 0.282 0.229 False True IGHV1 IGLV2 Lambda 1.0999999999999999e-11 -14.95021525744087 Unknown TBD 2qtj D N 9 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5gzo H L 0 A protein genome polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/16 Structure of neutralizing antibody bound to Zika envelope protein HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F. 2.755 X-RAY DIFFRACTION 0.277 0.231 False True IGHV4 IGKV1 Kappa 1.6359999999999998e-07 -9.258056023338968 SPR TBD 6qex C B 0 A protein multidrug resistance protein 1 MEMBRANE PROTEIN 01/08/19 Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alam, A., Locher, K.P. 3.6 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 2kh2 B b 59 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 1oax H L 0 H Hapten ANQ ACENAPHTHENEQUINONE IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with acenaphthenequinone RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.67 X-RAY DIFFRACTION 0.282 0.238 False True IGHV1 IGLV1 Lambda None None None None None 4nhg I F 0 IMMUNE SYSTEM 11/05/13 Crystal Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West, Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 8.001 X-RAY DIFFRACTION 0.369 0.359 False True unknown IGKV1 Kappa None None None None None 3ujj H L 0 P peptide gp120 IMMUNE SYSTEM 11/07/11 Crystal structure of anti-HIV-1 V3 Fab 4025 in complex with Con A peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.P., Sampson, J. 2.0 X-RAY DIFFRACTION 0.213 0.177 False False IGHV5 IGLV3 Lambda None None None None None 6oao F f 0 E protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 092096 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 3.497 X-RAY DIFFRACTION 0.279 0.238 True True unknown unknown unknown None None None None None 6ey0 F NA 0 B protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 N-terminal part (residues 30-212) of PorM with the llama naobody nb01 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Roche, J., Cambillau, C., Roussel, A. 2.4 X-RAY DIFFRACTION 0.242 0.213 False True IGHV1 None None None None None 6tgg H h 0 P peptide mucin-1 ANTITUMOR PROTEIN 04/08/20 scFv-1SM3 in complex with glycopeptide containing an sp2-imino sugar MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Bermejo, I.A., Navo, C.D., Castro-Lopez, J., Samchez-Fernandez, E.M., Guerreiro, A., Avenoza, A., Busto, J.H., Garcia-Martin, F., Nishimura, S.I., Garcia-Fernandez, J.M., Ortiz-Mellet, C., Bernardes, G.J.L., Hurtado-Guerrero, R., Peregrina, J.M., Corzana, F. 2.0 X-RAY DIFFRACTION 0.238 0.175 True True unknown unknown unknown None None None None None 4rau Q P 0 R protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 6phd H L 0 C protein 25 kda ookinete surface antigen IMMUNE SYSTEM 06/25/19 Pfs25 in complex with the human transmission blocking antibody 2586 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum McLeod, B.R., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.231 0.213 False True IGHV3 IGLV3 Lambda None None None None None 5wcd H L 0 IMMUNE SYSTEM 06/29/17 Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 04-1D02 Fab. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Andrews, S.F., Mascola, J.R., McDermott, A.B., Kwong, P.D. 1.814 X-RAY DIFFRACTION 0.216 0.177 False True IGHV3 IGLV2 Lambda None None None None None 7che H L 0 R protein NA sars-cov-2 receptor binding domain ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab and BD-368-2 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J., Zhu, Q. 3.416 X-RAY DIFFRACTION 0.239 0.225 False True IGHV3 IGKV1 Kappa None None None None None 6p62 F G 0 E protein hiv-1 env bg505 nfl td+ VIRAL PROTEIN/immune system 05/31/19 HIV Env BG505 NFL TD+ in complex with antibody E70 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 4y5x G H 0 I protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 3.15 X-RAY DIFFRACTION 0.241 0.201 False True IGHV3 IGLV1 Lambda None None None None None 7rso H L 0 A protein NA amc016 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/11/21 AMC016 SOSIP.v4.2 in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Cottrell, C.A., Ward, A.B. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7tat D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/21 SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (two receptor-binding domains open) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 3csy G H 0 P | O protein | protein NA | NA envelope glycoprotein gp2 | envelope glycoprotein gp1 IMMUNE SYSTEM/VIRAL PROTEIN 04/10/08 Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor HOMO SAPIENS; ZAIRE EBOLA VIRUS homo sapiens homo sapiens zaire ebola virus | zaire ebola virus Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O. 3.4 X-RAY DIFFRACTION 0.302 0.261 False True IGHV3 IGKV4 Kappa None None None None None 6z6v G NA 0 B | C protein | protein NA | NA complement c1q subcomponent subunit b | complement c1q subcomponent subunit c IMMUNE SYSTEM 05/29/20 Globular head of C1q in complex with the nanobody C1qNb75 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Laursen, N.S., Andersen, G.R. 2.19 X-RAY DIFFRACTION 0.227 0.178 False True IGHV1 NA NA None None None None None 7lvw I NA 0 D protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/26/21 Structure of RSV F in Complex with VHH Cl184 RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama respiratory syncytial virus Hsieh, C.-L., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.230 0.201 False True IGHV1 NA NA None None None None None 7duq N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 BIOSYNTHETIC PROTEIN 01/11/21 Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Cong, Z., Chen, L., Ma, H., Zhou, Q., Zou, X., Ye, C., Dai, A., Liu, Q., Huang, W., Sun, X., Wang, X., Xu, P., Zhao, L., Xia, T., Zhong, W., Yang, D., Xu, H.E., Zhang, Y., Wang, M. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6cde h l 0 d protein unknown VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 7bel E F 0 X protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-88 and COVOX-45 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.53 X-RAY DIFFRACTION 0.286 0.249 False True IGHV4 IGLV1 Lambda None None None None None 6bck H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 10/20/17 Crystal Structure of Broadly Neutralizing Antibody N49P7 in Complex with HIV-1 Clade AE strain 93TH057 gp120 core. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 2.7 X-RAY DIFFRACTION 0.285 0.225 False True unknown IGLV2 Lambda 8.6e-10 -12.367556905430469 Unknown TBD 7dwt H L 0 A protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/18/21 Cryo-EM structure of Dengue virus serotype 1 strain WestPac 74 in complex with human antibody 1C19 Fab at 37 deg C (Class 1 particle) DENGUE VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens dengue virus 1 Fibriansah, G., Ng, T.S., Kostyuchenko, V.A., Shi, J., Lok, S.M. 19 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 6w51 S T 0 NA NA NA NA IMMUNE SYSTEM 03/12/20 Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Wright, K.M., Gabelli, S.B. 3.53 X-RAY DIFFRACTION 0.283 0.200 False True IGHV3 IGKV1 Kappa None None None None None 6m87 D C 0 D Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 08/21/18 Fab 10A6 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.609 X-RAY DIFFRACTION 0.265 0.228 False False IGHV1 IGKV4 Kappa None None None None None 6e4y H L 0 P peptide proprotein convertase subtilisin/kexin type 9 IMMUNE SYSTEM 04/10/19 Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9, unmodified MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Ultsch, M.H., Kirchhofer, D.K. 2.24 X-RAY DIFFRACTION 0.255 0.212 False True IGHV6 IGKV2 Kappa None None None None None 2xzq H L 0 P peptide phage display derived antigen IMMUNE SYSTEM 12/01/10 CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-(4-HYDROXY-3-NITROPHENYL)- ACETYL MURINE GERMLINE MONOCLONAL ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE YQLRPNAETLRF MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.4 X-RAY DIFFRACTION 0.2506 0.2407 False False IGHV1 IGLV1 Lambda 2.6e-07 -8.983583688639808 Unknown TBD 6nmr A B 0 E protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.42 X-RAY DIFFRACTION 0.323 0.289 False True IGHV3 IGKV3 Kappa None None None None None 7wrz H L 0 R protein NA spike protein s1 VIRAL PROTEIN 01/28/22 Local resolution of BD55-5840 Fab and SARS-COV2 Omicron RBD SARS coronavirus B012 sars coronavirus b012 sars coronavirus b012 sars coronavirus b012 Zhang, Z.Z., Xiao, J.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV3 Kappa None None None None None 5kg9 A B 0 IMMUNE SYSTEM 06/13/16 Crystal structure of the gp120 v2 antibody RE505-22 Fab from IGH- and IGK-humanized mouse MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Nicely, N.I. 2.3 X-RAY DIFFRACTION 0.281 0.240 False True IGHV3 IGLV3 Lambda None None None None None 5ijk B D 0 Y peptide peptide pro-leu-gln-pro-glu-gln-pro-phe-pro IMMUNE SYSTEM 03/02/16 Crystal structure of anti-gliadin 1002-1E03 Fab fragment in complex of peptide PLQPEQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens triticum aestivum Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 2.5 X-RAY DIFFRACTION 0.265 0.209 False True IGHV3 IGKV4 Kappa None None None None None 7q0i H L 0 C protein NA spike protein s1 VIRAL PROTEIN 10/14/21 Crystal structure of the N-terminal domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-43 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.39 X-RAY DIFFRACTION 0.242 0.202 False True IGHV3 IGLV3 Lambda None None None None None 4qti H L 0 U protein urokinase plasminogen activator surface receptor IMMUNE SYSTEM 07/08/14 Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhao, B., Yuan, C., Luo, Z., Huang, M. 3.0 X-RAY DIFFRACTION 0.296 0.250 False False IGHV1 IGKV9 Kappa 1.7200000000000002e-08 -10.592634423700435 SPR TBD 4g80 A B 0 S protein voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (WT, 3.8 A) HOMO SAPIENS; CIONA INTESTINALIS homo sapiens homo sapiens ciona intestinalis Li, Q. 3.58 X-RAY DIFFRACTION 0.292 0.248 False True IGHV3 IGKV1 Kappa None None None None None 5w6c H L 0 IMMUNE SYSTEM 06/16/17 UCA Fab (unbound) from 6649 Lineage HOMO SAPIENS homo sapiens homo sapiens Raymond, D.D., Harrison, S.C. 1.634 X-RAY DIFFRACTION 0.201 0.177 False True IGHV4 IGLV1 Lambda None None None None None 6fyt I NA 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/12/18 Structure of H1 (A/solomon Islands/3/06) Influenza Hemagglutinin in complex with SD38 INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); LAMA GLAMA lama glama influenza a virus (a/solomonislands/3/2006(h1n1)) | influenza a virus (a/solomonislands/3/2006(h1n1)) Laursen, N.S., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.235 0.200 False True IGHV1 None None None None None 7kn5 F NA 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobodies VHH E and U SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 1.87 X-RAY DIFFRACTION 0.213 0.177 False True IGHV1 NA NA None None None None None 6mpg Q R 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 5tpl H L 0 IMMUNE SYSTEM 10/20/16 Crystal Structure of DH270.3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.5 X-RAY DIFFRACTION 0.249 0.215 False True IGHV1 IGLV2 Lambda None None None None None 7n3h H L 0 NA NA NA NA IMMUNE SYSTEM 06/01/21 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C099 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J., Barnes, C.O. 1.26 X-RAY DIFFRACTION 0.202 0.180 False True IGHV3 IGKV3 Kappa None None None None None 1g9e A NA 9 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 4fnl H L 0 IMMUNE SYSTEM 06/19/12 Crystal structure of broadly neutralizing antibody C05 HOMO SAPIENS homo sapiens homo sapiens Ekiert, D.C., Wilson, I.A. 2.297 X-RAY DIFFRACTION 0.240 0.212 False True IGHV3 IGKV1 Kappa None None None None None 3qxt A NA 0 A Hapten MTX METHOTREXATE IMMUNE SYSTEM 03/02/11 Structure of an Anti-Methotrexate CDR1-3 Graft VHH Antibody in Complex with Methotrexate LAMA GLAMA lama glama lama glama Fanning, S.W., Horn, J.R. 1.7 X-RAY DIFFRACTION 0.195 0.175 False True IGHV1 6e-06 -7.123876292458442 Unknown TBD 5ku0 7 NA 0 3 protein vp3 Virus/Immune System 07/12/16 expanded poliovirus in complex with VHH 17B CAMELUS DROMEDARIUS; POLIOVIRUS TYPE 1 (STRAIN MAHONEY) camelus dromedarius poliovirus type 1 (strain mahoney) Strauss, M., Schotte, L., Filman, D.J., Hogle, J.M. 4.2 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6wm9 B C 0 A protein NA reticulocyte binding protein 2b CELL INVASION 04/20/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 237235 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.45 X-RAY DIFFRACTION 0.279 0.223 False True IGHV3 IGLV2 Lambda None None None None None 5jor B C 0 NA NA NA NA IMMUNE SYSTEM 05/02/16 Crystal structure of unbound anti-glycan antibody Fab14.22 at 2.2 A MUS MUSCULUS mus musculus mus musculus Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A. 2.206 X-RAY DIFFRACTION 0.237 0.205 False True IGHV1 IGKV1 Kappa None None None None None 6xw5 D NA 0 B protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5820 MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 1.72 X-RAY DIFFRACTION 0.191 0.161 False True IGHV1 None None None None None 2q20 NA A 0 PROTEIN FIBRIL 05/25/07 Structure of the germline Vk1 O18/O8 light chain variable domain homodimer HOMO SAPIENS homo sapiens Thompson, J.R., Ramirez-Alvarado, M., Baden, E.M. 1.3 X-RAY DIFFRACTION 0.148 0.119 False True IGKV1 Kappa None None None None None 3dwt F NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 7mkl H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/24/21 SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-38 (three down conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Adams, L.J., Fremont, D.H. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV4 Kappa None None None None None 3iyw H L 0 A protein polyprotein VIRUS 06/18/10 West Nile virus in complex with Fab fragments of MAb CR4354 (fitted coordinates of envelope proteins and Fab fragments of one icosahedral ASU) WEST NILE VIRUS; HOMO SAPIENS homo sapiens homo sapiens west nile virus Rossmann, M.G., Kaufmann, B. 13.7 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 5c8j C D 0 L protein protein mj0480 MEMBRANE PROTEIN 06/25/15 A YidC-like protein in the archaeal plasma membrane HOMO SAPIENS; METHANOCALDOCOCCUS JANNASCHII (STRAIN ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) homo sapiens homo sapiens methanocaldococcus jannaschii (strain atcc43067 / dsm 2661 / jal-1 / jcm 10045 / nbrc 100440) Borowska, M.T., Dominik, P.K., Anghel, S.A., Kossiakoff, A.A., Keenan, R.J. 3.502 X-RAY DIFFRACTION 0.302 0.253 False True IGHV3 IGKV1 Kappa None None None None None 6iap H L 0 A protein natural cytotoxicity triggering receptor 1 IMMUNE SYSTEM 11/27/18 structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Roussel, A., Amigues, B. 2.9 X-RAY DIFFRACTION 0.263 0.187 False True IGHV1 IGKV1 Kappa None None None None None 7zf5 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-12 and Beta-54 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 5.32 X-RAY DIFFRACTION 0.256 0.249 False True IGHV4 IGKV1 Kappa None None None None None 6x5n h l 0 r nucleic-acid NA unknown Immune System/RNA 05/26/20 Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Swain, M., Li, M., Woldawer, A., LeGrice, S.F.J. 3.3 X-RAY DIFFRACTION 0.267 0.180 False False IGHV3 IGKV1 Kappa None None None None None 2fx9 H L 0 P peptide fragment of hiv glycoprotein gp41 IMMUNE SYSTEM 02/03/06 Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a thioether-linked peptide encompassing the 4e10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Brunel, F.M., Ferguson, S., Burton, D.R., Dawson, P.E., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.271 0.236 False True IGHV1 IGKV3 Kappa 1.70e-08 -10.59 SPR 17125793 4u3x C NA 0 D protein lysozyme c IMMUNE SYSTEM 07/23/14 Structure of a human VH antibody domain binding to the cleft of hen egg lysozyme HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Rouet, R., Langley, D.B., Christ, D. 2.26 X-RAY DIFFRACTION 0.248 0.189 False True IGHV3 None None None None None 4nnp H L 0 A protein lipoprotein TRANSPORT PROTEIN/IMMUNE SYSTEM 11/18/13 Crystal Structure of Apo Manganese ABC transporter MntC from Staphylococcus aureus bound to an antagonistic fab fragment HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS homo sapiens homo sapiens staphylococcus aureus subsp. aureus Rouge, L., Sudhamsu, J. 2.69 X-RAY DIFFRACTION 0.283 0.224 False True IGHV3 IGKV1 Kappa None None None None None 4xwo I J 0 G protein sec22 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 5zia A B 0 C peptide phosphorylated tau peptide IMMUNE SYSTEM 03/14/18 Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, H., Wilson, I.A. 2.603 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGKV4 Kappa 3e-07 -8.898798774188476 Unknown TBD 3k80 B NA 0 D protein mp18 rna editing complex protein Immune System, RNA Binding Protein 10/13/09 Structure of essential protein from Trypanosoma brucei LAMA GLAMA; TRYPANOSOMA BRUCEI lama glama trypanosoma brucei Wu, M. 2.4 X-RAY DIFFRACTION 0.277 0.223 False True IGHV1 None None None None None 3lex H L 0 P peptide envelope glycoprotein gp41 IMMUNE SYSTEM 01/15/10 2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D. 1.97 X-RAY DIFFRACTION 0.198 0.165 False False IGHV3 IGKV1 Kappa None None None None None 3ggw B A 0 E peptide peptide b1 IMMUNE SYSTEM 03/02/09 Crystal Structure of FAB F22-4 in complex with a Carbohydrate-mimetic peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Saul, F.A., Vulliez-Le Normand, B., Bentley, G.A. 1.7 X-RAY DIFFRACTION 0.245 0.197 False False IGHV6 IGKV2 Kappa 2.90e-06 -7.55 ITC 25 19328810 4dkf H L 0 A protein interleukin-34 CYTOKINE/IMMUNE SYSTEM 02/03/12 Crystal Structure of Human Interleukin-34 Bound to FAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ma, X., Chen, Y., Stawicki, S., Wu, Y., Bazan, J.F., Starovasnik, M.A. 2.61 X-RAY DIFFRACTION 0.256 0.225 False True IGHV3 IGKV1 Kappa 3.1000000000000005e-09 -11.607859518116271 SPR TBD 6ug7 H L 0 H carbohydrate GAL polysaccharide IMMUNE SYSTEM 09/26/19 Complex of ch28/11 Fab and SSEA-4 (tetragonal form) MUS MUSCULUS mus musculus mus musculus mus musculus Soliman, C., Ramsland, P.A. 1.52 X-RAY DIFFRACTION 0.198 0.172 False True IGHV2 IGKV4 Kappa None None None None None 6h7j C NA 0 A protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.8 X-RAY DIFFRACTION 0.317 0.285 False True IGHV1 None None None None None 5jw5 H L 0 IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 1.9 X-RAY DIFFRACTION 0.217 0.187 False True IGHV6 IGKV1 Kappa None None None None None 3qwo H L 0 P protein motavizumab epitope scaffold Immune System 02/28/11 Crystal structure of a motavizumab epitope-scaffold bound to motavizumab Fab MUS MUSCULUS; STAPHYLOCOCCUS AUREUS mus musculus mus musculus staphylococcus aureus McLellan, J.S., Kwong, P.D. 1.9 X-RAY DIFFRACTION 0.231 0.188 False True IGHV2 IGKV1 Kappa 8.70e-08 -9.63 SPR 21549714 4gms J N 0 E protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/16/12 Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Lee, P.S., Ekiert, D.C., Wilson, I.A. 2.95 X-RAY DIFFRACTION 0.233 0.207 False True IGHV1 IGKV6 Kappa 2e-08 -10.503274322962254 BLI TBD 6uum B A 0 A carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/30/19 Crystal structure of antibody 438-B11 DSS mutant (Cys98A-Cys100aA) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kumar, S., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.269 0.229 False True unknown IGKV3 Kappa None None None None None 5uqy P O 0 M | F protein | protein NA | NA envelope glycoprotein gp1 | envelope glycoprotein gp2 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/17 Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 LAKE VICTORIA MARBURGVIRUS (STRAIN RAVN-87); HOMO SAPIENS homo sapiens homo sapiens lake victoria marburgvirus (strain ravn-87) | lake victoria marburgvirus (strain ravn-87) Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O. 3.6 X-RAY DIFFRACTION 0.262 0.221 False False IGHV4 IGKV1 Kappa None None None None None 6n4r L K 0 C | D | H protein | protein | peptide NA | NA | NA nav1.7 vsd2-navab chimera | nav1.7 vsd2-navab chimera | beta/omega-theraphotoxin-tp2a MEMBRANE PROTEIN 11/20/18 CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2 ARCOBACTER BUTZLERI (STRAIN RM4018); HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus arcobacter butzleri (strain rm4018), homosapiens | arcobacter butzleri (strain rm4018), homosapiens | thrixopelma pruriens Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M. 4.2 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 4xgz A B 0 a peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 6a0x G H 0 IMMUNE SYSTEM 06/06/18 Crystal structure of broadly neutralizing antibody 13D4 MUS MUSCULUS mus musculus mus musculus Li, S., Li, T. 2.3 X-RAY DIFFRACTION 0.243 0.205 False False IGHV1 IGKV6 Kappa None None None None None 2iqa B A 0 IMMUNE SYSTEM 10/13/06 PFA2 FAB fragment, monoclinic apo form MUS MUSCULUS mus musculus mus musculus Gardberg, A.S., Dealwis, C. 2.0 X-RAY DIFFRACTION 0.279 0.230 False False IGHV8 IGKV1 Kappa None None None None None 5jny A B 0 IMMUNE SYSTEM 05/01/16 Crystal Structure of 10E8 Fab HOMO SAPIENS homo sapiens homo sapiens Ofek, G., Kwong, P. 3.041 X-RAY DIFFRACTION 0.215 0.188 False True IGHV3 IGLV3 Lambda None None None None None 7jx3 H L 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/26/20 Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Rosen, L.E., Nix, J.C., Corti, D., Veesler, D., Park, Y.J., Walls, A.C., Tortorici, M.A., Cameroni, E., Pinto, D., Beltramello, M. 2.65 X-RAY DIFFRACTION 0.288 0.258 False True IGHV3 IGKV1 Kappa None None None None None 7nvn N NA 0 E protein NA t-complex protein 1 subunit epsilon CHAPERONE 03/15/21 Human TRiC complex in closed state with nanobody and tubulin bound HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7kex G J 0 A protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-293 HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4z7o E F 0 C protein NA integrin alpha-iib Membrane protein/Immune system 04/07/15 Integrin alphaIIbbeta3 in complex with AGDV peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lin, F.Y., Zhu, J., Springer, T.A. 2.85 X-RAY DIFFRACTION 0.257 0.223 False True IGHV14 IGKV14 Kappa None None None None None 7rfc A B 0 C protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 07/14/21 Crystal structure of broadly neutralizing antibody mAb1382 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain HOMO SAPIENS; HEPACIVIRUS C homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 3.24 X-RAY DIFFRACTION 0.284 0.233 False True IGHV1 IGKV3 Kappa None None None None None 7o06 A NA 0 C protein NA centrosomal protein of 164 kda STRUCTURAL PROTEIN 03/25/21 Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 10Z CAMELIDAE MIXED LIBRARY; HOMO SAPIENS camelidae mixed library homo sapiens e Silva, I.R., van Breugel, M. 1.6 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 NA NA None None None None None 7mww H L 0 E protein NA core protein precursor ee2 VIRAL PROTEIN/IMMUNE SYSTEM 05/17/21 Structure of hepatitis C virus envelope full-length glycoprotein 2 (eE2) from J6 genotype HEPACIVIRUS C; MUS MUSCULUS mus musculus mus musculus hepacivirus c Kumar, A., Hossain, R.A., Yost, S.A., Bu, W., Wang, Y., Dearborn, A.D., Grakoui, A., Cohen, J.I., Marcotrigiano, J. 2.71 X-RAY DIFFRACTION 0.270 0.218 False True IGHV14 IGKV8 Kappa None None None None None 6wez H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/Immune System 04/03/20 Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H3 Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Harshbarger, W.D., Lockbaum, G.J., Deming, D.T., Attatippaholkun, N., Schiffer, C.A., Marasco, W.A. 3.21 X-RAY DIFFRACTION 0.281 0.233 False True IGHV3 IGLV1 Lambda None None None None None 7lmr NA B 0 B Hapten 9ZX 4-methyl-3-(morpholin-4-ylmethyl)-7-[(2~{S})-2-phenylpropoxy]chromen-2-one IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 63 [4-methyl-3-(morpholinomethyl)-7-(2-phenylpropoxy)-2H-chromen-2-one] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.09 X-RAY DIFFRACTION 0.261 0.202 False True NA IGLV6 Lambda None None None None None 5t5n M L 0 C protein bestrophin-1 (best1) MEMBRANE PROTEIN 08/31/16 Calcium-activated chloride channel bestrophin-1 (BEST1), triple mutant: I76A, F80A, F84A; in complex with an Fab antibody fragment, chloride, and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Long, S.B., Vaisey, G. 3.1 X-RAY DIFFRACTION 0.243 0.218 False False IGHV1 IGKV12 Kappa None None None None None 7dge C NA 0 A protein NA metabotropic glutamate receptor 1 MEMBRANE PROTEIN 11/11/20 intermediate state of class C GPCR HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Zhang, J.Y., Wu, L.J., Luo, F., Hua, T., Liu, Z.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3chn B M 1 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 6and H L 0 IMMUNE SYSTEM 08/12/17 Pinatuzumab Fab in complex with anti-Kappa VHH domain LAMA GLAMA; HOMO SAPIENS homo sapiens homo sapiens Ereno-Orbea, J., Sicard, T., Julien, J.-P. 1.75 X-RAY DIFFRACTION 0.290 0.241 False True IGHV3 IGKV1 Kappa 7.8e-09 -11.061162015777013 Unknown TBD 5vyf B A 0 C protein chimera of major allergen i polypeptide chain 2,majorallergen i polypeptide chain 1 IMMUNE SYSTEM 05/25/17 Structure of single chain Fel d 1 bound to a neutralizing antibody MUS MUSCULUS; FELIS CATUS mus musculus mus musculus felis catus Franklin, M.C. 2.9 X-RAY DIFFRACTION 0.259 0.225 False True IGHV3 IGKV1 Kappa 1.87e-10 -13.271582589129338 SPR TBD 6cue M N 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6nc2 H L 0 B | A protein | protein NA | NA amc011 v4.2 sosip gp41 | amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B. 5.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6u85 H L 0 IMMUNE SYSTEM 09/04/19 Site-specific lysine arylation as an alternative bioconjugation strategy for chemically programmed antibodies and antibody-drug conjugates HOMO SAPIENS homo sapiens homo sapiens Park, H., Rader, C. 2.78 X-RAY DIFFRACTION 0.259 0.211 False True IGHV6 IGKV1 Kappa None None None None None 6vca K J 0 C protein NA 5'-nucleotidase, ecto (cd73), isoform cra_a IMMUNE SYSTEM 12/20/19 TB38 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhou, Y.F., Lord, D.M. 3.73 X-RAY DIFFRACTION 0.264 0.224 False True IGHV3 IGLV8 Lambda None None None None None 2q76 B A 0 IMMUNE SYSTEM 06/06/07 Mouse anti-hen egg white lysozyme antibody F10.6.6 Fab fragment MUS MUSCULUS mus musculus mus musculus Cauerhff, A., Klinke, S., Acierno, J.P., Goldbaum, F.A., Braden, B.C. 2.0 X-RAY DIFFRACTION 0.233 0.196 False False IGHV1 IGKV5 Kappa None None None None None 6pxg E F 0 IMMUNE SYSTEM 07/26/19 Crystal Structure of MERS-CoV neutralizing antibody G2 Fab MUS MUSCULUS mus musculus mus musculus Wang, N., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.225 0.181 False True IGHV1 IGKV3 Kappa None None None None None 5f6j H F 0 E protein envelope glycoprotein gp120 of hiv-1 clade c Viral Protein/Immue System 12/06/15 Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Fera, D., Harrison, S.C. 6.63 X-RAY DIFFRACTION 0.305 0.256 False True IGHV3 IGLV2 Lambda None None None None None 7l7e H L 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV1 IGKV3 Kappa None None None None None 4m3j B NA 0 IMMUNE SYSTEM 08/06/13 Structure of a single-domain camelid antibody fragment cAb-H7S specific of the BlaP beta-lactamase from Bacillus licheniformis LAMA GLAMA lama glama Pain, C., Kerff, F., Herman, R., Sauvage, E., Preumont, S., Charlier, P., Dumoulin, M. 1.95 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 None None None None None 2uyl W V 0 IMMUNE SYSTEM 04/10/07 Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1 MUS MUSCULUS mus musculus mus musculus Ahmed, F., Haouz, A., Nato, F., Fournier, J.M., Alzari, P.M. 2.5 X-RAY DIFFRACTION 0.257 0.211 False False IGHV1 IGKV1 Kappa None None None None None 4kzd H L 0 R nucleic-acid rna (84-mer) immune system/rna 05/29/13 Crystal structure of an RNA aptamer in complex with fluorophore and Fab MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus Huang, H., Suslov, N.B., Li, N., Koldobskaya, Y., Rice, P.A., Piccirilli, J.A. 2.186 X-RAY DIFFRACTION 0.211 0.179 False True IGHV3 IGKV1 Kappa None None None None None 6pzw J G 0 B protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-22 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 5dmj G NA 0 F protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 09/08/15 Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB HOMO SAPIENS homo sapiens homo sapiens Sheriff, S. 2.79 X-RAY DIFFRACTION 0.258 0.229 False True IGHV3 5.3e-09 -11.290107730486941 SPR TBD 5vj6 H L 0 E protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/18/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 11.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 5nbl E NA 0 C | B protein | protein NA | NA actin | actin-related protein 4 HYDROLASE 03/02/17 Crystal structure of the Arp4-N-actin(APO-state) heterodimer bound by a nanobody SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS; TRICHOPLUSIA NI vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) Knoll, K.R., Eustermann, S., Hopfner, K.P. 2.8 X-RAY DIFFRACTION 0.204 0.171 False True IGHV1 None None None None None 5nb5 I M 0 IMMUNE SYSTEM 03/01/17 Principles for computational design of antibodies ESCHERICHIA COLI Dym, O., Fleishman, S.J. 3.0 X-RAY DIFFRACTION 0.257 0.223 False True IGHV3 IGKV3 Kappa None None None None None 7n8h E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/14/21 SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5kov K k 0 H protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 7a4d G NA 0 K peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 6f0d B NA 0 IMMUNE SYSTEM 11/19/17 Crystal structure of a llama VHH antibody BCD090-M2 against human ErbB3 in space group P1 with cadmium ions LAMA GLAMA lama glama Eliseev, I.E., Yudenko, A.N., Vysochinskaya, V.V., Svirina, A.A., Evstratyeva, A.V., Drozhzhachih, M.S., Krendeleva, E.A., Vladimirova, A.K., Nemankin, T.A., Ekimova, V.M., Ulitin, A.B., Lomovskaya, M.I., Yakovlev, P.A., Moiseenko, F.V., Chakchir, O.B. 1.90001 X-RAY DIFFRACTION 0.218 0.174 False True IGHV1 None None None None None 5nbm E NA 0 C | B protein | protein NA | NA actin | actin-related protein 4 HYDROLASE 03/02/17 Crystal structure of the Arp4-N-actin(ATP-state) heterodimer bound by a nanobody SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS; TRICHOPLUSIA NI vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) Knoll, K.R., Eustermann, S., Hopfner, K.P. 3.4 X-RAY DIFFRACTION 0.193 0.152 False True IGHV1 None None None None None 1aif H L 0 IMMUNOGLOBULIN 11/14/94 ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A) FAB FROM MOUSE MUS MUSCULUS mus musculus mus musculus Ban, N., Escobar, C., Hasel, K., Day, J., Greenwood, A., McPherson, A. 2.9 X-RAY DIFFRACTION unknown 0.220 False False IGHV6 IGKV4 Kappa None None None None None 6dzv B C 0 A protein sodium-dependent serotonin transporter TRANSPORT PROTEIN/IMMUNE SYSTEM 07/05/18 Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Yang, D., Gouaux, E. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6qn8 E F 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV Fab B13 BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.12 X-RAY DIFFRACTION 0.267 0.235 False True IGHV1 IGLV1 Lambda None None None None None 6e5p S T 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 6jht E D 0 C protein vp3 VIRUS 02/19/19 The cryo-EM structure of HAV bound to a neutralizing antibody-F9 HUMAN HEPATITIS A VIRUS HU/AUSTRALIA/HM175/1976 human hepatitis a virushu/australia/hm175/1976 human hepatitis a virushu/australia/hm175/1976 human hepatitis a virushu/australia/hm175/1976 Cao, L., Liu, P., Yang, P., Gao, Q., Li, H., Sun, Y., Zhu, L., Lin, J., Su, D., Rao, Z., Wang, X. 3.79 ELECTRON MICROSCOPY False False IGHV5 IGKV4 Kappa None None None None None 6bzu C D 0 I peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Kong, L., Wilson, I.A., Law, M. 2.7 X-RAY DIFFRACTION 0.290 0.265 False True IGHV3 IGKV3 Kappa None None None None None 5tkj A B 0 C peptide hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 10/06/16 Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.118 X-RAY DIFFRACTION 0.241 0.198 False True IGHV1 IGKV1 Kappa 7.150000000000001e-09 -11.112714836617695 Unknown TBD 6g8r A a 0 PEPTIDE BINDING PROTEIN 04/09/18 SP140 PHD-Bromodomain complex with scFv HOMO SAPIENS homo sapiens Fairhead, M., Graslund, S., Strain-Damerell, C., Picaud, S.S., Pike, A.C.W., Pinkas, D.M., Wigren, E., Preger, C., Persson Lotsholm, H., Ossipova, E., Filippakopoulos, P., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Structural Genomics Consortium (SGC) 2.74 X-RAY DIFFRACTION 0.266 0.226 True True unknown unknown unknown None None None None None 3zhl A NA 0 12/22/12 The crystal structure of single domain antibody 8-14 scaffold ESCHERICHIA COLI Song, H.-N., Woo, E.-J., Lim, H.-K. 2.47 X-RAY DIFFRACTION 0.2458 0.1916 False True IGHV3 None None None None None 3wsq H L 0 A protein receptor tyrosine-protein kinase erbb-2 TRANSFERASE/IMMUNE SYSTEM 03/20/14 Structure of HER2 with an Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fu, W.Y., Wang, Y.X., Zhou, L.J. 3.5 X-RAY DIFFRACTION 0.258 0.221 False True IGHV1 IGLV1 Lambda None None None None None 5kn5 D E 0 F peptide protransforming growth factor alpha IMMUNE SYSTEM 06/27/16 TGFalpha/Epiregulin complex with neutralizing antibody LY3016859 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Atwell, S., Boyles, J.S., Clawson, D.K., Druzina, Z., Josef, G.H., Weichert, K., Witcher, D.R. 2.8 X-RAY DIFFRACTION 0.263 0.206 False True IGHV1 IGKV4 Kappa 1.02e-10 -13.630708160608433 Unknown TBD 6cse H L 0 M protein sodium/alanine symporter agcs MEMBRANE PROTEIN 03/20/18 Crystal structure of sodium/alanine symporter AgcS with L-alanine bound METHANOCOCCUS MARIPALUDIS (STRAIN S2 / LL); MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis (strain s2 / ll) Ma, J., Reyes, F.E., Gonen, T. 3.24 X-RAY DIFFRACTION 0.251 0.230 False False IGHV6 IGKV12 Kappa None None None None None 7m7h E F 0 B protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 chimera BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1' SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7k8t O P 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Malyutin, A.G., Barnes, C.O., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3mcg NA 1 0 IMMUNOGLOBULIN 05/09/89 THREE-DIMENSIONAL STRUCTURE OF A LIGHT CHAIN DIMER CRYSTALLIZED IN WATER. CONFORMATIONAL FLEXIBILITY OF A MOLECULE IN TWO CRYSTAL FORMS HOMO SAPIENS homo sapiens Ely, K.R., Herron, J.N., Edmundson, A.B. 2.0 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 6qnk D C 0 IMMUNE SYSTEM 02/11/19 Antibody FAB fragment targeting Gi protein heterotrimer MUS MUSCULUS mus musculus mus musculus Tsai, C.-J., Muehle, J., Pamula, F., Dawson, R.J.P., Maeda, S., Deupi, X., Schertler, G.F.X. 1.9 X-RAY DIFFRACTION 0.212 0.180 False True IGHV5 IGKV2 Kappa None None None None None 5zia D E 0 F peptide phosphorylated tau peptide IMMUNE SYSTEM 03/14/18 Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, H., Wilson, I.A. 2.603 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGKV4 Kappa 3e-07 -8.898798774188476 Unknown TBD 5xf1 H L 0 B protein glucagon receptor,endolysin,glucagon receptor SIGNALING PROTEIN 04/06/17 Structure of the Full-length glucagon class B G protein-coupled receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens, enterobacteria phage t4 Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.Y., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. 3.19 X-RAY DIFFRACTION 0.231 0.205 False True IGHV3 IGKV1 Kappa None None None None None 5cba A B 0 E protein c-x-c motif chemokine 13 IMMUNE SYSTEM 06/30/15 3B4 in complex with CXCL13 - 3B4-CXCL13 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tu, C., Bard, J., Mosyak, L. 2.5 X-RAY DIFFRACTION 0.237 0.197 True True IGHV1 IGLV2 Lambda None None None None None 6lz9 H L 0 B protein hepatocyte growth factor IMMUNE SYSTEM 02/18/20 t8E4 antibody Fab complexed with the active form of HGF HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kitago, Y., Umitsu, M., Takagi, J. 2.8 X-RAY DIFFRACTION 0.298 0.248 False True IGHV2 IGKV10 Kappa None None None None None 5jmo C NA 0 A protein furin Hydrolase/Antibody 04/29/16 X-ray structure of a protease-antibody complex CAMELUS DROMEDARIUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT camelus dromedarius homo sapiens Dahms, S.O., Than, M.E. 1.998 X-RAY DIFFRACTION 0.197 0.163 False True IGHV3 None None None None None 7k7i X Y 0 E protein NA putative pertussis-like toxin subunit TOXIN 09/22/20 Density-fitted Model Structure of Antibody Variable Domains of TyTx4 in Complex with PltB pentamer of Typhoid Toxin SALMONELLA TYPHI; MUS MUSCULUS mus musculus mus musculus salmonella typhi Nguyen, T., Feathers, J.R., Fromme, J.C., Song, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 2ajx H L 0 L Hapten TGN 3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER IMMUNE SYSTEM 08/02/05 Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with Transition State Analog MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.255 0.227 False False IGHV3 IGKV2 Kappa None None None None None 2kh2 B b 42 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7cm4 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/24/20 Crystal Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody CT-P59 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y.G., Jeong, J.H., Bae, J.S., Lee, J.H. 2.71 X-RAY DIFFRACTION 0.242 0.217 False True IGHV2 IGLV1 Lambda None None None None None 1ieh A NA 1 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 6vzi D E 0 B protein envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 02/28/20 Crystal Structure of HIV-1 CAP256 RnS-3mut-2G-SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.716 X-RAY DIFFRACTION 0.276 0.229 False True unknown unknown unknown None None None None None 6uoe H L 0 P peptide NA envelope glycoprotein b IMMUNE SYSTEM/VIRAL PROTEIN 10/14/19 3-25 Fab germline-reversion variant bound to an HCMV gB-derived peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human betaherpesvirus 5 Wrapp, D., McLellan, J.S. 1.8 X-RAY DIFFRACTION 0.186 0.160 False True IGHV3 IGKV3 Kappa None None None None None 6phg A B 0 IMMUNE SYSTEM 06/25/19 Predicted germline variant of human transmission blocking antibody 2544 HOMO SAPIENS homo sapiens homo sapiens McLeod, B.R., Julien, J.P. 2.0 X-RAY DIFFRACTION 0.228 0.182 False True IGHV3 IGKV2 Kappa None None None None None 7k9h H L 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/20 SARS-CoV-2 Spike in complex with neutralizing Fab 2B04 (one up, two down conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Errico, J.M., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 2ez0 E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 11/10/05 Crystal structure of the S107A/E148Q/Y445A mutant of EcClC, in complex with a FaB fragment ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lobet, S., Dutzler, R. 3.54 X-RAY DIFFRACTION 0.296 0.258 False False IGHV4 IGKV4 Kappa None None None None None 5n2k L K 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 4fqv J N 0 D | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody CR9114 bound to H7 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Ekiert, D.C., Dreyfus, C., Wilson, I.A. 5.75 X-RAY DIFFRACTION 0.339 0.314 False True IGHV1 IGLV1 Lambda 1.1000000000000001e-09 -12.22172707862036 BLI TBD 3bjl NA A 0 IMMUNOGLOBULIN 05/26/95 LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.3 X-RAY DIFFRACTION unknown unknown False False IGLV1 Lambda None None None None None 2mkw NA A 17 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 2kh2 B b 33 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5da4 B NA 0 IMMUNE SYSTEM 08/19/15 Structure of a nanobody recognizing the fumarate transporter SLC26Dg LAMA GLAMA lama glama Dutzler, R., Geertsma, E.R., Chang, Y., Shaik, F.R. 2.4 X-RAY DIFFRACTION 0.242 0.233 False True IGHV1 None None None None None 7te6 G H 0 F | E protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody XENOPUS LAEVIS; RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | xenopus laevis Regan, M., Tajima, N., Furukawa, H. 4.55 X-RAY DIFFRACTION 0.324 0.282 False False IGHV5 IGKV3 Kappa None None None None None 6djp E F 0 B protein integrin beta-8 MEMBRANE PROTEIN 05/25/18 Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Cormier, A., Campbell, M.G., Nishimura, S.L., Cheng, Y. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV10 Kappa None None None None None 6cvk A a 0 C protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/28/18 Hepatitis B e-antigen in complex with scFv e13 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS oryctolagus cuniculus hepatitis b virus Eren, E., Steven, A.C., Wingfield, P.T. 2.38 X-RAY DIFFRACTION 0.221 0.175 True True unknown unknown unknown None None None None None 3cfj B A 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, orthorhombic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.253 0.199 False True IGHV4 IGLV1 Lambda None None None None None 5xcs A B 0 C peptide ha peptide IMMUNE SYSTEM 03/23/17 Crystal structure of 12CA5 Fv-clasp fragment with its antigen peptide MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 2.2 X-RAY DIFFRACTION 0.244 0.208 False True IGHV5 IGKV8 Kappa None None None None None 7rah B A 0 E protein NA bifunctional adenylate cyclase toxin/hemolysin cyaa,bifunctional adenylate cyclase toxin/hemolysin cyaa IMMUNE SYSTEM/TOXIN 07/01/21 Adenylate cyclase toxin RTX domain fragment bound to M1H5 Fab and M2B10 Fab MUS MUSCULUS; BORDETELLA PERTUSSIS mus musculus mus musculus bordetella pertussis Goldsmith, J.A., McLellan, J.S. 2.6 X-RAY DIFFRACTION 0.218 0.195 False True IGHV5 IGKV10 Kappa None None None None None 7zmo K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-052 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.75 X-RAY DIFFRACTION 0.306 0.283 False True IGHV1 NA NA None None None None None 7n3i H L 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/01/21 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment C098 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Flyak, A.I., Bjorkman, P.J., Barnes, C.O. 2.03 X-RAY DIFFRACTION 0.208 0.179 False True IGHV3 IGKV3 Kappa None None None None None 5uk4 o NA 0 O protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 2znw B b 0 Z protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 05/02/08 Crystal Structure of ScFv10 in Complex with Hen Egg Lysozyme MUS MUSCULUS; SYNTHETIC CONSTRUCT; GALLUS GALLUS mus musculus, synthetic construct gallus gallus DeSantis, M.E., Acchione, M., Li, M., Walter, R.L., Wlodawer, A., Smith-Gill, S. 2.71 X-RAY DIFFRACTION 0.250 0.193 True True unknown unknown unknown None None None None None 6jfh K I 0 A protein zikv structural e protein ANTIVIRAL PROTEIN 04/10/19 The asymmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q. 20 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 6feq D C 0 B protein atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 01/03/18 Structure of inhibitor-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Altmann, K.H., Locher, K.P. 3.6 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 7paf C NA 0 A protein NA licb protein TRANSPORT PROTEIN 07/29/21 Streptococcus pneumoniae choline importer LicB in lipid nanodiscs SYNTHETIC CONSTRUCT; STREPTOCOCCUS PNEUMONIAE TIGR4 synthetic construct streptococcus pneumoniae tigr4 Perez, C., Baerland, N. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2c1p B A 0 B Hapten FNZ 4-[(1S,2R)-3-(4-FLUOROPHENYL)-2-HYDROXY-1-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]BENZONITRILE IMMUNE SYSTEM 09/19/05 Fab-fragment of enantioselective antibody complexed with finrozole MUS MUSCULUS mus musculus mus musculus mus musculus Parkkinen, T., Nevanen, T., Koivula, A., Rouvinen, J. 2.0 X-RAY DIFFRACTION 0.2853 0.2302 False True IGHV1 IGKV1 Kappa 4e-06 -7.3641077518219635 Unknown TBD 6iyn A NA 2 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 4kkc E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 20mM Bromide MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.18 X-RAY DIFFRACTION 0.264 0.231 False True IGHV4 IGKV4 Kappa None None None None None 6kz0 H I 0 G protein genome polyprotein VIRAL PROTEIN 05/27/20 HRV14 3C in complex with single chain antibody GGVV HUMAN RHINOVIRUS 14; HOMO SAPIENS homo sapiens homo sapiens human rhinovirus 14 Meng, B., Yang, B., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.223 0.185 False True IGHV1 IGKV1 Kappa None None None None None 4xmk H L 0 P peptide hiv-1 jr-fl gp120 v3 peptide immune system/viral protein 01/14/15 Crystal structure of Fab of HIV-1 gp120 V3-specific human monoclonal antibody 2424 in complex with JR-FL V3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P., Pan, R. 3.179 X-RAY DIFFRACTION 0.283 0.225 False True IGHV3 IGKV2 Kappa None None None None None 7kfh I L 0 C protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437 EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6cwt C D 0 F protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/30/18 Hepatitis B core-antigen in complex with Fab e21 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS GENOTYPE D SUBTYPE ADW oryctolagus cuniculus oryctolagus cuniculus hepatitis b virus genotype d subtype adw Eren, E., Steven, A.C., Wingfield, P.T. 3.151 X-RAY DIFFRACTION 0.283 0.231 False True IGHV1 IGKV1 Kappa 2e-12 -15.960250680603272 AUC TBD 7ey5 B C 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/29/21 Local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-771 Fab and BD-821 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z.Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 6snh H L 0 X protein dolichyl pyrophosphate man9glcnac2 alpha-1,3-glucosyltransferase MEMBRANE PROTEIN 08/24/19 Cryo-EM structure of yeast ALG6 in complex with 6AG9 Fab and Dol25-P-Glc SACCHAROMYCES CEREVISIAE; SYNTHETIC CONSTRUCT synthetic construct synthetic construct saccharomyces cerevisiae Bloch, J.S., Pesciullesi, G., Boilevin, J., Nosol, K., Irobalieva, R.N., Darbre, T., Aebi, M., Kossiakoff, A.A., Reymond, J.L., Locher, K.P. 3.9 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 1qbm H L 0 IMMUNOGLOBULIN 05/01/98 FAB E8B ANTIBODY, X-RAY STRUCTURE AT 2.37 ANGSTROMS RESOLUTION MUS MUSCULUS mus musculus mus musculus Mylvaganam, S.E., Paterson, Y., Getzoff, E.D. 2.37 X-RAY DIFFRACTION 0.269 0.194 False False IGHV14 IGKV12 Kappa None None None None None 4hkx A B 0 E protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 10/15/12 Influenza hemagglutinin in complex with CH67 Fab INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Schmidt, A.G., Harrison, S.C. 2.5 X-RAY DIFFRACTION 0.219 0.187 False True IGHV1 IGLV3 Lambda 3.6e-07 -8.790776227275865 SPR TBD 3hr5 B A 0 S peptide m1prime-derived peptide IMMUNE SYSTEM 06/08/09 M1prime peptide from IgE bound by humanized antibody 47H4 Fab MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Eigenbrot, C.W., Ultsch, M.H. 2.4 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 5v8m S U 0 G protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/22/17 A broadly neutralizing antibody targets the dynamic HIV Envelope trimer apex via a long, rigidified, and anionic beta-hairpin structure HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Cottrell, C.A., Ward, A.B. 4.4 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7lbe F E 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 01/07/21 CryoEM structure of the HCMV Trimer gHgLgO in complex with neutralizing fabs 13H11 and MSL-109 HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN); HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus (strain merlin) Kschonsak, M., Rouge, L., Arthur, C.P., Hoangdung, H., Patel, N., Kim, I., Johnson, M., Kraft, E., Rohou, A.L., Gill, A., Martinez-Martin, N., Payandeh, J., Ciferri, C. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7pry C D 0 I protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with COVOX-45 and beta-6 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.1 X-RAY DIFFRACTION 0.291 0.245 False True IGHV4 IGKV3 Kappa None None None None None 6xun A B 0 F carbohydrate NAG N-ACETYL-D-GLUCOSAMINE ANTITUMOR PROTEIN 01/20/20 Ab 5b1 bound to CA19-9 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.215 0.169 False True IGHV3 IGLV1 Lambda None None None None None 6ck9 H L 0 G protein gp120 of envelope glycoprotein gp160 VIRAL PROTEIN 02/27/18 Crystal Structure of HIV-1 ConC_Base0 Prefusion Env Trimer in Complex with Human Antibody Fragment 3H109L and 35O22 variants at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.714 X-RAY DIFFRACTION 0.288 0.248 False True IGHV4 unknown unknown None None None None None 1jv5 B A 0 Immune System, Sugar Binding Protein 08/28/01 Anti-blood group A Fv HOMO SAPIENS homo sapiens homo sapiens Thomas, R., Patenaude, S.I., MacKenzie, C.R., To, R., Hirama, T., Young, N.M., Evans, S.V. 2.2 X-RAY DIFFRACTION 0.223 0.183 False True IGHV1 IGKV1 Kappa None None None None None 6xcm N S 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/08/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 2vyr I NA 0 IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 7zmr C NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2*-011 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.3 X-RAY DIFFRACTION 0.292 0.243 False True IGHV1 NA NA None None None None None 7k8y G I 0 B | D protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Abernathy, M.E., Barnes, C.O., Bjorkman, P.J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6vo3 I K 0 D protein NA amc009 sosip.v4.2 envelope glycoprotein gp120 IMMUNE SYSTEM 01/29/20 AMC009 SOSIP.v4.2 in complex with PGV04 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., de Val, N., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7nda H L 0 C | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-253H55L Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3c08 H L 0 IMMUNE SYSTEM 01/18/08 Crystal structure the Fab fragment of matuzumab/EMD72000 (Fab72000) HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Ferguson, K.M., Schmiedel, J., Knoechel, T. 2.15 X-RAY DIFFRACTION 0.264 0.224 False True IGHV1 IGKV1 Kappa None None None None None 3tnn E F 0 IMMUNE SYSTEM 09/01/11 Crystal structure of N5-i5 Fab, an ADCC mediating and non-neutralizing CD4i anti-HIV- 1 antibody. HOMO SAPIENS homo sapiens homo sapiens Wu, X., Pazgier, M. 1.95 X-RAY DIFFRACTION 0.245 0.198 False True IGHV3 IGLV2 Lambda None None None None None 6war D NA 0 C protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 6jep K I 0 F protein genome polyprotein ANTIVIRAL PROTEIN 02/07/19 Structure of a neutralizing antibody bound to the Zika envelope protein domain III HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q. 2.316 X-RAY DIFFRACTION 0.219 0.166 False True IGHV1 IGLV1 Lambda None None None None None 5udd M S 0 F | E protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F B9320 Bound to MEDI8897 HUMAN RESPIRATORY SYNCYTIAL VIRUS 9320; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus 9320 | human respiratory syncytial virus 9320 McLellan, J.S. 4.3 X-RAY DIFFRACTION 0.295 0.237 False True IGHV1 IGKV1 Kappa None None None None None 4kdt A NA 0 D protein beta-2-microglobulin IMMUNE SYSTEM 04/25/13 Structure of an early native-like intermediate of beta2-microglobulin amyloidosis CAMELIDAE; HOMO SAPIENS camelidae homo sapiens Vanderhaegen, S., Fislage, M., Pardon, E., Versees, W., Steyaert, J. 2.6 X-RAY DIFFRACTION 0.274 0.226 False True IGHV1 None None None None None 7tus E F 0 NA NA NA NA IMMUNE SYSTEM 02/03/22 Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation HOMO SAPIENS homo sapiens homo sapiens Park, H., Rader, C. 2.4 X-RAY DIFFRACTION 0.257 0.218 False True IGHV6 IGKV1 Kappa None None None None None 7kbb A B 0 E | C protein | protein NA | NA ul131a | envelope protein ul128 VIRAL PROTEIN/IMMUNE SYSTEM 10/01/20 Cryo-EM structure of the HCMV pentamer bound by Fabs 2-18 and 8I21 HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS homo sapiens homo sapiens human cytomegalovirus | human cytomegalovirus Wrapp, D., McLellan, J.S. 4.02 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5x2p J K 0 C protein NA taste receptor, type 1, member 2a SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-glutamate ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.608 X-RAY DIFFRACTION 0.228 0.153 False True IGHV1 IGKV3 Kappa None None None None None 2fjf H L 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 7pi3 R S 0 O protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 7nx8 H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the K417T mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 1.95 X-RAY DIFFRACTION 0.246 0.223 False True IGHV3 IGKV1 Kappa None None None None None 5sx4 H L 0 N protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 08/09/16 Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sickmier, E.A., Kurzeja, R.J.M., Michelsen, K., Mukta, V., Yang, E., Tasker, A.S. 2.8 X-RAY DIFFRACTION 0.266 0.223 False True IGHV4 IGKV1 Kappa 3.4000000000000007e-10 -12.917373922881485 SPR TBD 7vsw B A 0 NA NA NA NA BIOSYNTHETIC PROTEIN 10/27/21 Crystal structure of a Fab-like fragment of anti-mesothelin antibody HOMO SAPIENS homo sapiens homo sapiens Yang, Z., Ying, T. 3.0 X-RAY DIFFRACTION 0.253 0.217 False True IGHV4 IGKV1 Kappa None None None None None 3dvg B A 0 Y | X protein | protein NA | NA ubiquitin | ubiquitin d77 IMMUNE SYSTEM 07/18/08 Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Hymowitz, S.G. 2.6 X-RAY DIFFRACTION 0.261 0.219 False True IGHV3 IGKV1 Kappa 8.70e-09 -10.99 SPR 18724939 7cqd I M 0 B protein NA putative zinc metalloprotease aq_1964,pa14 from podoplanin,putative zinc metalloprotease aq_1964 HYDROLASE/IMMUNE SYSTEM 08/10/20 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 235 and 236 RATTUS NORVEGICUS; AQUIFEX AEOLICUS VF5; HOMO SAPIENS rattus norvegicus rattus norvegicus aquifex aeolicus vf5, homo sapiens Tamura-Sakaguchi, R., Aruga, R., Nogi, T. 3.2 X-RAY DIFFRACTION 0.286 0.265 False True IGHV5 IGLV3 Lambda None None None None None 1i8i B A 0 C peptide epidermal growth factor receptor, egfrviiipeptide antigen IMMUNE SYSTEM 03/14/01 CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT ROOM TEMPERATURE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Landry, R.C., Klimowicz, A.C., Lavictoire, S.J., Borisova, S., Kottachchi, D.T., Lorimer, I.A., Evans, S.V. 2.4 X-RAY DIFFRACTION 0.262 0.156 False True IGHV5 IGKV17 Kappa 2.2000000000000002e-08 -10.446804596890326 Unknown TBD 3cfi L NA 0 K protein type ii secretory pathway, pseudopilin epsj PROTEIN TRANSPORT/Immune system 03/03/08 Nanobody-aided structure determination of the EPSI:EPSJ pseudopilin heterdimer from Vibrio Vulnificus VIBRIO VULNIFICUS; LAMA GLAMA lama glama vibrio vulnificus Lam, A.Y., Pardon, E., Korotkov, K.V., Steyaert, J., Hol, W.G.J. 2.58 X-RAY DIFFRACTION 0.279 0.229 False True IGHV3 None None None None None 6dbd B NA 0 IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R326 LAMA GLAMA lama glama Brooks, C.L., Toride King, M., Huh, I. 1.755 X-RAY DIFFRACTION 0.182 0.160 False True unknown unknown unknown None None None None None 7uap M N 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/13/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1520 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 6idi H L 0 D protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 8.0. DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 12 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 4x0k H L 0 IMMUNE SYSTEM 11/21/14 Engineered Fab fragment specific for EYMPME (EE) peptide HOMO SAPIENS homo sapiens homo sapiens Johnson, J.L., Lieberman, R.L. 2.04 X-RAY DIFFRACTION 0.207 0.165 False True IGHV1 IGKV1 Kappa None None None None None 6wvz H L 0 M protein NA hepatocyte growth factor receptor Transferase/Immune System 05/07/20 Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cardoso, R.M.F. 3.1 X-RAY DIFFRACTION 0.235 0.190 False True IGHV1 IGKV1 Kappa None None None None None 3phq B A 0 B carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID CARBOHYDRATE-BINDING PROTEIN 11/04/10 Crystal structure of S64-4 in complex with KDO MUS MUSCULUS mus musculus mus musculus mus musculus Evans, D.W., Evans, S.V. 2.0 X-RAY DIFFRACTION 0.275 0.227 False False IGHV7 IGKV3 Kappa None None None None None 7n4m H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2151. HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 3.79 X-RAY DIFFRACTION 0.317 0.258 False True IGHV4 IGLV6 Lambda None None None None None 7cwu P I 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 2xqy G L 0 A protein envelope glycoprotein h IMMUNE SYSTEM/VIRAL PROTEIN 09/08/10 Crystal structure of Pseudorabies core fragment of glycoprotein H in complex with Fab d6.3 SUID HERPESVIRUS; MUS MUSCULUS mus musculus mus musculus suid herpesvirus Backovic, M., Dubois, R., Cockburn, J., Sharff, A., Vaney, M., Granzow, H., Klupp, B., Bricogne, G., Mettenleiter, T., Rey, F. 2.05 X-RAY DIFFRACTION 0.2046 0.1878 False True IGHV1 IGKV3 Kappa None None None None None 7pi3 P Q 0 O protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 1lo2 Y X 0 Y Hapten OX1 ? IMMUNE SYSTEM 05/06/02 Retro-Diels-Alderase Catalytic Antibody MUS MUSCULUS mus musculus mus musculus mus musculus Hugot, M., Reymond, J.L., Baumann, U. 2.0 X-RAY DIFFRACTION 0.248 0.210 False False IGHV5 IGKV1 Kappa None None None None None 4xvu K L 0 G protein nyv1 tmd HYDROLASE/TRANSPORT PROTEIN 01/28/15 Structure of Get3 bound to the transmembrane domain of Nyv1 SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE; HOMO SAPIENS, SYNTHETIC CONSTRUCT homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.35 X-RAY DIFFRACTION 0.234 0.197 False True IGHV3 IGKV1 Kappa None None None None None 7wgt H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 12/28/21 X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in complex with NO711. Drosophila melanogaster; Mus musculus mus musculus mus musculus drosophila melanogaster Joseph, D., Penmatsa, A. 2.75 X-RAY DIFFRACTION 0.296 0.248 False True IGHV5 IGKV4 Kappa None None None None None 4rgn B C 0 A protein enterotoxin type b TOXIN/IMMUNE SYSTEM 09/30/14 Structure of Staphylococcal Enterotoxin B bound to two neutralizing antibodies, 14G8 and 6D3 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Franklin, M.C., Dutta, K., Varshney, A.K., Goger, M.J., Fries, B.C. 2.698 X-RAY DIFFRACTION 0.278 0.240 False False IGHV5 IGKV5 Kappa None None None None None 6tkb H L 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 ChiLob 7/4 H2 HC-C224S F(ab')2 HOMO SAPIENS Orr, C.M., Fisher, H., Tews, I. 2.0 X-RAY DIFFRACTION 0.229 0.182 False False IGHV1 IGKV10 Kappa None None None None None 1i8k B A 0 C peptide epidermal growth factor receptor, egfrviiipeptide antigen IMMUNE SYSTEM 03/14/01 CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Landry, R.C., Klimowicz, A.C., Lavictoire, S.J., Borisova, S., Kottachchi, D.T., Lorimer, I.A., Evans, S.V. 1.8 X-RAY DIFFRACTION 0.224 0.172 False True IGHV5 IGKV17 Kappa 2.20e-08 -10.44 SPR 11352579 6o3k H L 0 IMMUNE SYSTEM 02/26/19 Crystal structure of the unbound Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Wilson, I.A. 1.451 X-RAY DIFFRACTION 0.191 0.156 False True IGHV1 IGKV3 Kappa None None None None None 7tyy N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/14/22 Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4kuz H L 0 IMMUNE SYSTEM 05/22/13 Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.7 X-RAY DIFFRACTION 0.268 0.230 False True IGHV1 IGKV8 Kappa None None None None None 4plk H L 0 A protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 05/18/14 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12 HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Li, S.W., Sivaraman, J. 4.0 X-RAY DIFFRACTION 0.296 0.264 False False IGHV1 IGKV12 Kappa None None None None None 1oau K NA 0 IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 1.8 X-RAY DIFFRACTION 0.264 0.226 False True IGHV1 2.00e-08 Other 20 12610298 4uif G H 0 A protein dengue virus serotype 2 strain pvp94 07 - envelopeprotein 03/30/15 Cryo-EM structure of Dengue virus serotype 2 in complex with antigen- binding fragments of human antibody 2D22 DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.-N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Junior, J.E., Lok, S.-M. 6.5 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 7sn3 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/21 Structure of human SARS-CoV-2 spike glycoprotein trimer bound by neutralizing antibody C1C-A3 Fab (variable region) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Shankar, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3rhw I O 0 D protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.26 X-RAY DIFFRACTION 0.270 0.239 False True IGHV1 IGLV1 Lambda None None None None None 5jqd D A 0 IMMUNE SYSTEM 05/04/16 Antibody Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Zhang, Z., Prachanronarong, K., Gellatly, K., Marasco, W.A., Schiffer, C.A. 2.591 X-RAY DIFFRACTION 0.242 0.212 False True IGHV1 IGKV3 Kappa None None None None None 6ana H L 0 IMMUNE SYSTEM 08/12/17 LL2 Fab in complex with anti-Kappa VHH domain LAMA GLAMA; MUS MUSCULUS mus musculus mus musculus Sicard, T., Ereno Orbea, J., Julien, J.-P. 1.7 X-RAY DIFFRACTION 0.237 0.215 False True IGHV1 IGKV8 Kappa 9.000000000000001e-09 -10.976377101325681 Unknown TBD 7sod H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S NTD B.1.617.1 kappa variant S2L20 Local Refinement HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6oca D NA 0 B protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V2G10 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 2.113 X-RAY DIFFRACTION 0.247 0.213 False True IGHV1 None None None None None 4lve NA A 0 IMMUNOGLOBULIN 05/12/98 LEN K30T MUTANT: A DOMAIN FLIP AS A RESULT OF A SINGLE AMINO ACID SUBSTITUTION HOMO SAPIENS homo sapiens Schiffer, M., Pokkuluri, P.R. 2.3 X-RAY DIFFRACTION 0.267 0.190 False True IGKV4 Kappa None None None None None 7rga C NA 0 C Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoCLAMP3:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Alexandrov, K. 2.9 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 7a3p H L 0 A protein NA envelope protein e VIRAL PROTEIN 08/18/20 Crystal structure of dengue 3 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10 DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 3.19 X-RAY DIFFRACTION 0.284 0.241 False True IGHV1 IGLV2 Lambda None None None None None 6vbq E F 0 J peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH822 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.116 X-RAY DIFFRACTION 0.211 0.181 False True IGHV1 IGLV3 Lambda None None None None None 2a6i B A 0 P peptide dodecapeptide IMMUNE SYSTEM 07/02/05 Crystal structure analysis of the anti-arsonate germline antibody 36-65 in complex with a phage display derived dodecapeptide KLASIPTHTSPL MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M. 2.5 X-RAY DIFFRACTION 0.264 0.245 False False IGHV1 IGKV10 Kappa 1.20e-07 -9.44 SPR 25 16618601 1ic4 H L 0 Y protein lysozyme c PROTEIN BINDING/HYDROLASE 03/30/01 CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD32A)-HEN LYSOZYME COMPLEX MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Yokota, A., Tsumoto, K., Kondo, H., Nishimiya, Y., Horii, K., Matsushima, M., Ogasahara, K., Yutani, K., Kumagai, I. 2.5 X-RAY DIFFRACTION 0.279 0.181 False True IGHV3 IGKV5 Kappa None None None None None 7lex D E 0 B protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7d5q D NA 0 B protein NA drug transporter, putative MEMBRANE PROTEIN 09/27/20 Structure of NorC transporter (K398A mutant) in an outward-open conformation in complex with a single-chain Indian camelid antibody STAPHYLOCOCCUS AUREUS SUBSP. AUREUS COL; CAMELUS DROMEDARIUS camelus dromedarius staphylococcus aureus subsp. aureus col Kumar, S., Athreya, A., Penmatsa, A. 3.6 X-RAY DIFFRACTION 0.315 0.308 False True IGHV1 NA NA None None None None None 1maj NA A 6 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 2kh2 B b 64 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7cwu M R 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5udd L R 0 D | H protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F B9320 Bound to MEDI8897 HUMAN RESPIRATORY SYNCYTIAL VIRUS 9320; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus 9320 | human respiratory syncytial virus 9320 McLellan, J.S. 4.3 X-RAY DIFFRACTION 0.295 0.237 False True IGHV1 IGKV1 Kappa None None None None None 1aj7 H L 0 H Hapten NPE 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID IMMUNOGLOBULIN 05/15/97 IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY MUS MUSCULUS; HOMO SAPIENS homo sapiens mus musculus homo sapiens Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C. 2.1 X-RAY DIFFRACTION 0.258 0.217 False True IGHV14 IGKV9 Kappa 1.35e-04 -5.31 SPR 27 9180069 6osy I J 0 G protein bg505 gp41 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True IGHV4 IGKV1 Kappa None None None None None 4fqr m n 0 M protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 7ttx H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/02/22 Crystal structure of potent neutralizing antibody 10-40 in complex with Sarbecovirus bat RaGT13 receptor-binding domain BAT CORONAVIRUS RATG13; HOMO SAPIENS homo sapiens homo sapiens bat coronavirus ratg13 Reddem, E.R., Shapiro, L. 2.8 X-RAY DIFFRACTION 0.321 0.222 False True IGHV4 IGLV6 Lambda None None None None None 7kjh A NA 0 C protein NA surface protein p12p UNKNOWN FUNCTION 10/26/20 Plasmodium falciparum protein Pf12p bound to nanobody B9 VICUGNA PACOS; PLASMODIUM FALCIPARUM vicugna pacos plasmodium falciparum Dietrich, M.H., Tham, W.H. 2.0 X-RAY DIFFRACTION 0.217 0.180 False True IGHV1 NA NA None None None None None 2kh2 B b 57 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6uyg H L 0 E protein envelope glycoprotein e2 IMMUNE SYSTEM 11/13/19 Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3B and non neutralizing antibody E1 RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1; HOMO SAPIENS; STREPTOCOCCUS SP. homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Zhu, J. 3.375 X-RAY DIFFRACTION 0.306 0.254 False True IGHV1 IGKV3 Kappa None None None None None 7fjn I J 0 A protein NA spike glycoprotein,envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/04/21 Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, human immunodeficiency virus 1 Wang, X., Zhang, L., Zhang, S., Liang, Q. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 6n81 H L 0 A protein major capsid protein IMMUNE SYSTEM 11/28/18 Crystal structure of GII.4 2002 norovirus P domain in complex with cross-reactive human antibody A1227 NOROVIRUS HU/GII.4/FARMINGTON HILLS/2004/USA; HOMO SAPIENS homo sapiens homo sapiens norovirus hu/gii.4/farmington hills/2004/usa Changela, A., Verardi, R., Kwong, P.D. 2.579 X-RAY DIFFRACTION 0.211 0.173 False True IGHV3 IGKV1 Kappa None None None None None 6fe4 I NA 0 D protein shiga-like toxin 2 subunit b TOXIN 12/29/17 Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113 ENTEROBACTERIA PHAGE 933W; VICUGNA PACOS vicugna pacos enterobacteria phage 933w Bernedo, R., Muyldermans, S., Sterckx, Y.G.J. 3.0 X-RAY DIFFRACTION 0.207 0.169 False True IGHV3 9.6e-09 -10.938139080820335 SPR TBD 2kqm NA B 3 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 4rrp G A 0 M protein antigen asf1p IMMUNE SYSTEM 11/06/14 Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Kuzin, A., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Oconnell, P.T., Maglaqui, M., Bailey, L., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG) 2.79 X-RAY DIFFRACTION 0.253 0.183 False True IGHV3 IGKV1 Kappa None None None None None 6pb0 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(i) subunit alpha- 1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 06/12/19 Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ma, S., Shen, Q., Zhao, L.-H., Mao, C., Zhou, X.E., Shen, D.-D., de Waal, P.W., Bi, P., Li, C., Jiang, Y., Wang, M.-W., Sexton, P.M., Wootten, D., Melcher, K., Zhang, Y., Xu, H.E. 3 ELECTRON MICROSCOPY False True IGHV3 None None None None None 2zpk I M 0 Q peptide proteinase-activated receptor 4 IMMUNE SYSTEM 07/16/08 Crystal structure of P20.1 Fab fragment in complex with its antigen peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Nogi, T., Sanagawa, T., Takagi, J. 1.8 X-RAY DIFFRACTION 0.204 0.172 False False IGHV9 IGLV1 Lambda 1.47e-06 -7.95 SPR 25 18787202 7ll1 H L 0 A protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/03/21 Cryo-EM structure of BG505 DS-SOSIP in complex with glycan276-dependent broadly neutralizing antibody VRC40.01 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.73 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 5m2w B NA 0 IMMUNE SYSTEM 10/13/16 Structure of nanobody nb18 raised against TssK from E. coli T6SS LAMA GLAMA lama glama Cambillau, C., Nguyen, V.S., Spinelli, S., Desmyter, A. 1.5 X-RAY DIFFRACTION 0.214 0.203 False True IGHV1 None None None None None 3nn8 D E 0 IMMUNE SYSTEM 06/23/10 Crystal structure of engineered antibody fragment based on 3D5 MUS MUSCULUS mus musculus mus musculus Lieberman, R.L., Maynard, J.A., Drury, J.E., Pai, J., Culver, J.A. 3.1 X-RAY DIFFRACTION 0.238 0.183 True True IGHV1 IGKV1 Kappa None None None None None 1u0q B NA 0 IMMUNE SYSTEM 07/14/04 Structure of a Llama VHH domain raised against a carbazole molecule LAMA GLAMA lama glama Cambillau, C., Spinelli, S., Desmyter, A., Verrips, T. 1.6 X-RAY DIFFRACTION 0.250 0.221 False True IGHV1 None None None None None 4rdq G F 0 E protein bestrophin-1 TRANSPORT PROTEIN 09/19/14 Calcium-activated chloride channel bestrophin-1, from chicken, in complex with Fab antibody fragments, chloride and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Dickson, V.K., Pedi, L., Long, S.B. 2.85 X-RAY DIFFRACTION 0.234 0.217 False False IGHV1 IGKV12 Kappa 1.5000000000000002e-08 -10.67372125591851 Unknown TBD 2pcp D C 0 C Hapten 1PC 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE IMMUNOGLOBULIN 06/02/98 ANTIBODY FAB COMPLEXED WITH PHENCYCLIDINE MUS MUSCULUS mus musculus mus musculus mus musculus Lim, K., Owens, S.M., Arnold, L., Sacchettini, J.C., Linthicum, D.S. 2.2 X-RAY DIFFRACTION 0.290 0.196 False False IGHV1 IGKV1 Kappa 2e-09 -11.867518412372508 Unknown TBD 6dc9 H L 0 P peptide microtubule-associated protein tau IMMUNE SYSTEM 05/04/18 Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chukwu, J.E., Kong, X.-P. 2.999 X-RAY DIFFRACTION 0.260 0.202 False True IGHV14 IGKV15 Kappa None None None None None 7kf9 G J 0 A protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-296 and EBOV-515 HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 2x1p D NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama VandenAbbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., VanLoo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.1 X-RAY DIFFRACTION 0.220 0.203 False True IGHV1 None None None None None 6rcs A B 0 IMMUNE SYSTEM 04/11/19 PfRH5-binding monoclonal antibody R5.016 HOMO SAPIENS homo sapiens homo sapiens Alanine, D.W.G., Jamwal, A., Draper, S.J., Higgins, M.K. 2.1 X-RAY DIFFRACTION 0.223 0.204 False True IGHV1 IGKV1 Kappa None None None None None 6tou A a 0 G protein glycoprotein,glycoprotein VIRAL PROTEIN 12/12/19 Rabies virus glycoprotein PH domain in complex with the scFv fragment of broadly neutralizing human antibody RVC20 RABIES LYSSAVIRUS; HOMO SAPIENS homo sapiens rabies lyssavirus Hellert, J., Rey, F.A. 2.587 X-RAY DIFFRACTION 0.225 0.190 True True unknown unknown unknown None None None None None 6xm2 F E 0 I protein NA transforming growth factor beta-2 CYTOKINE/IMMUNE SYSTEM 06/29/20 The structure of the 4A11.v7 antibody in complex with human TGFb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lupardus, P.J., Yin, J.P. 1.91 X-RAY DIFFRACTION 0.244 0.205 False True IGHV4 IGKV3 Kappa None None None None None 7v0v A NA 11 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 3j5m L K 0 I protein bg505 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/26/13 Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lyumkis, D., Julien, J.-P., Wilson, I.A., Ward, A.B. 5.8 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 7mlh C A 0 F protein NA der p 2 variant 3 ALLERGEN/IMMUNE SYSTEM 04/28/21 Crystal structure of human IgE (2F10) in complex with Der p 2.0103 HOMO SAPIENS; DERMATOPHAGOIDES PTERONYSSINUS homo sapiens homo sapiens dermatophagoides pteronyssinus Khatri, K., Kapingidza, A.B., Richardson, C.M., Vailes, L.D., Wunschmann, S., Dolamore, C., Chapman, M.D., Smith, S.A., Pomes, A., Chruszcz, M. 2.1 X-RAY DIFFRACTION 0.247 0.210 False True IGHV1 IGKV1 Kappa None None None None None 2kqn NA A 17 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7xod T NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/01/22 SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA lama glama Xu, Y., Wu, C., Liu, H., Yin, W., Xu, H.E. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3s34 H L 0 IMMUNE SYSTEM 05/17/11 Structure of the 1121B Fab fragment MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Franklin, M.C. 2.2 X-RAY DIFFRACTION 0.223 0.183 False True IGHV3 IGKV1 Kappa None None None None None 6azm B A 0 E peptide circumsporozoite protein nanp 5-mer IMMUNE SYSTEM 09/11/17 Crystal structure of the 580 germline antibody bound to circumsporozoite protein NANP 5-mer HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 1.6 X-RAY DIFFRACTION 0.199 0.166 False True IGHV3 IGKV4 Kappa None None None None None 3ijs D C 0 D carbohydrate GP4 polysaccharide IMMUNE SYSTEM 08/04/09 Structure of S67-27 in Complex with TSBP MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.55 X-RAY DIFFRACTION 0.261 0.217 False False IGHV7 IGKV8 Kappa None None None None None 3clf H L 0 Immune System 03/18/08 HIV neutralizing monoclonal antibody YZ23 MUS MUSCULUS mus musculus mus musculus Symersky, J., Boivin, S., Paul, S. 2.0 X-RAY DIFFRACTION 0.265 0.220 False False IGHV1 IGKV6 Kappa None None None None None 5fwo A NA 0 IMMUNE SYSTEM 02/18/16 Llama nanobody PorM_130 LAMA GLAMA lama glama Leone, P., Roussel, A. 1.7 X-RAY DIFFRACTION 0.222 0.186 False True IGHV1 None None None None None 2o5y H L 0 IMMUNE SYSTEM 12/06/06 Crystal structure of the 1E9 LeuH47Trp/ArgH100Trp Fab progesterone complex MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Verdino, P., Wilson, I.A. 2.85 X-RAY DIFFRACTION 0.236 0.183 False True IGHV7 IGKV2 Kappa None None None None None 7sob G I 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5czx H L 0 A protein neurogenic locus notch homolog protein 3 IMMUNE SYSTEM 08/01/15 Crystal structure of Notch3 NRR in complex with 20358 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hu, T., Fryer, C., Chopra, R., Clark, K. 2.1 X-RAY DIFFRACTION 0.226 0.190 False False IGHV1 IGKV1 Kappa 6e-10 -12.580852650099459 SPR TBD 7k61 M m 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of 197bp nucleosome aided by scFv HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7r23 B NA 0 A protein NA arc STRUCTURAL PROTEIN 02/04/22 Crystal structure of human Arc CTD in complex with two anti-Arc nanobodies HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Markusson, S., Kursula, P. 2.77 X-RAY DIFFRACTION 0.302 0.252 False True IGHV1 NA NA None None None None None 5b8c E D 0 F protein programmed cell death protein 1 IMMUNE SYSTEM 06/14/16 High resolution structure of the human PD-1 in complex with pembrolizumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Horita, S., Shimamura, T., Iwata, S., Nomura, N. 2.146 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV3 Kappa None None None None None 4ala H L 0 C protein envelope protein IMMUNE SYSTEM 03/02/12 Structure of Dengue virus DIII in complex with Fab 2H12 DENGUE VIRUS 3; MUS MUSCULUS mus musculus mus musculus dengue virus 3 Midgley, C.M., Flanagan, A., Mongkolsapaya, J., Grimes, J.M., Screaton, G.R. 1.84 X-RAY DIFFRACTION 0.2139 0.1770 False False IGHV1 IGKV6 Kappa 4.7e-10 -12.725535363908449 ELISA TBD 1vhp A NA 13 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6oao H h 0 G protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 092096 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 3.497 X-RAY DIFFRACTION 0.279 0.238 True True unknown unknown unknown None None None None None 5u0u A a 0 IMMUNE SYSTEM 11/27/16 Crystal Structure of DH270.1 (unliganded, single-chain Fv) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens Fera, D., Harrison, S.C. 3.428 X-RAY DIFFRACTION 0.282 0.254 True True unknown unknown unknown None None None None None 6mco H L 0 G protein surface protein gp120 VIRAL PROTEIN 08/31/18 Crystal structure of the B41 SOSIP.664 Env trimer with PGT124 and 35O22 Fabs, in P23 space group HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Sarkar, A., Wilson, I.A. 3.526 X-RAY DIFFRACTION 0.322 0.306 False True IGHV4 unknown unknown None None None None None 2adi B A 0 IMMUNE SYSTEM 07/20/05 Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Barium MUS MUSCULUS mus musculus mus musculus Zhou, T., Hamer, D.H., Hendrickson, W.A., Sattentau, Q.J., Kwong, P.D. 2.8 X-RAY DIFFRACTION 0.269 0.210 False False IGHV5 IGKV17 Kappa None None None None None 2hwz H L 0 immune system 08/02/06 Fab fragment of Humanized anti-viral antibody MEDI-493 (Synagis TM) Braden, B. 1.8 X-RAY DIFFRACTION unknown unknown False True IGHV2 IGKV1 Kappa None None None None None 6vi2 B A 0 NA NA NA NA IMMUNE SYSTEM 01/11/20 Structure of the unaligned Fab4 HOMO SAPIENS homo sapiens homo sapiens Cingolani, G., Lokareddy, R., Ko, Y. 1.15 X-RAY DIFFRACTION 0.171 0.158 False True IGHV3 IGKV1 Kappa None None None None None 1dba H L 0 IMMUNOGLOBULIN 11/10/92 THREE-DIMENSIONAL STRUCTURE OF AN ANTI-STEROID FAB' AND PROGESTERONE-FAB' COMPLEX MUS MUSCULUS mus musculus mus musculus Arevalo, J.H., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.202 False True IGHV9 IGKV1 Kappa None None None None None 3j2x D C 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m242 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 15.6 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 5cp7 B C 0 IMMUNE SYSTEM 07/21/15 Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides MUS MUSCULUS mus musculus mus musculus Wang, Z., Shen, J., Li, C., Li, Y., Wen, K., Yu, X., Zhang, X. 3.01 X-RAY DIFFRACTION 0.302 0.260 False False IGHV3 IGKV1 Kappa None None None None None 5xqy NA B 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 5tkj G H 0 I peptide hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 10/06/16 Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.118 X-RAY DIFFRACTION 0.241 0.198 False True IGHV1 IGKV1 Kappa 7.150000000000001e-09 -11.112714836617695 Unknown TBD 3j2y H G 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab 9.8B MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 14.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 7dh5 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/12/20 Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; UNIDENTIFIED; CANIS LUPUS FAMILIARIS unidentified homo sapiens | rattus norvegicus Shihoya, W., Yamashita, K., Nureki, O. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6a79 H L 0 A protein roundabout homolog 1 IMMUNE SYSTEM 07/02/18 Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the mutant scFv fragment (P103A) of murine monoclonal antibody B5209B HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mizohata, E., Nakayama, T., Kado, Y., Yokota, Y., Inoue, T. 2.31 X-RAY DIFFRACTION 0.295 0.273 False True IGHV5 IGKV12 Kappa None None None None None 7v68 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/20/21 An Agonist and PAM-bound Class A GPCR with Gi protein complex structure HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Wang, J.J., Wu, L.J., Wu, M., Hua, T., Liu, Z.J., Wang, T. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4qww D C 0 B protein acetylcholinesterase HYDROLASE/IMMUNE SYSTEM 07/17/14 Crystal structure of the Fab410-BfAChE complex BUNGARUS FASCIATUS; MUS MUSCULUS mus musculus mus musculus bungarus fasciatus Bourne, Y., Renault, L., Marchot, P. 2.7 X-RAY DIFFRACTION 0.239 0.199 False False IGHV10 IGKV4 Kappa None None None None None 7kbp C c 0 NA NA NA NA PROTEIN BINDING 10/02/20 Herceptin Diabody with R83T, E85C Mutations HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 2.3 X-RAY DIFFRACTION 0.232 0.184 True True unknown unknown unknown None None None None None 7q9j E F 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-26 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 6veq I J 0 K protein insulin receptor subunit alpha TOXIN 06/03/20 Con-Ins G1 in complex with the human insulin microreceptor in turn in complex with Fv 83-7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Menting, J.G., Chou, D.H.-C., Lawrence, M.C., Xiong, X. 3.25 X-RAY DIFFRACTION 0.277 0.228 False True IGHV2 IGKV8 Kappa None None None None None 7kf1 D E 0 F protein NA isoform l-vegf206 of vascular endothelial growth factor a IMMUNE SYSTEM 10/13/20 Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M.S. 2.45 X-RAY DIFFRACTION 0.232 0.189 False True IGHV3 IGKV1 Kappa None None None None None 7p16 B NA 0 A protein NA xk-related protein MEMBRANE PROTEIN 07/01/21 Structure of caspase-3 cleaved rXKR9 in complex with a sybody at 4.3A RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT synthetic construct rattus norvegicus Straub, M.S., Sawicka, M., Dutzler, R. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3cm9 A L 5 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5aco G J 0 C protein hiv-1 envelope glycoprotein 08/17/15 Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.36 ELECTRON MICROSCOPY False True IGHV4 IGLV2 Lambda None None None None None 7ckw N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 CELL CYCLE 07/20/20 Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens | homo sapiens Yan, W., Shao, W. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7mmn H L 0 I protein NA fusion glycoprotein f1,fibritin IMMUNE SYSTEM/VIRAL PROTEIN 04/29/21 Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; ENTEROBACTERIA PHAGE T4 homo sapiens homo sapiens human respiratory syncytial virus,enterobacteria phage t4 Harshbarger, W., Malito, E. 3.57 X-RAY DIFFRACTION 0.245 0.202 False True IGHV3 IGKV1 Kappa None None None None None 7tqa A B 0 NA NA NA NA IMMUNE SYSTEM 01/26/22 Crystal Structure of monoclonal S9.6 Fab SYNTHETIC CONSTRUCT synthetic construct synthetic construct Bou Nader, C., Zhang, J. 2.328 X-RAY DIFFRACTION 0.235 0.179 False True IGHV1 IGKV1 Kappa None None None None None 7n9t F NA 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/18/21 CryoEM structure of SARS-CoV-2 Spike in complex with Nb17 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7p5v L NA 0 F protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7wk9 a b 0 B protein NA light chain of s3h3 fab VIRAL PROTEIN 01/08/22 SARS-CoV-2 Omicron open state spike protein in complex with S3H3 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 3.48 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 6bi2 H L 0 IMMUNE SYSTEM 10/31/17 Trastuzumab Fab D185A (Light Chain) Mutant Biotin Conjugation. HOMO SAPIENS homo sapiens homo sapiens DiDonato, M., Spraggon, G. 1.801 X-RAY DIFFRACTION 0.202 0.166 False True IGHV3 IGKV1 Kappa None None None None None 7kxk J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/04/20 SARS-CoV-2 spike protein in complex with Fab 15033-7, 2-""up""-1-""down"" conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J. 5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4x7d C NA 0 B protein vp1 VIRAL PROTEIN 12/09/14 Crystal structure of 2012 NSW GII.4 P domain in complex with Nano-85 NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; LAMA GLAMA lama glama norovirus hu/gii.4/sydney/nsw0514/2012/au Koromyslova, A.D., Hansman, G.S. 2.15 X-RAY DIFFRACTION 0.238 0.196 False True IGHV1 3.5000000000000003e-09 -11.535955190950428 ITC TBD 1ck0 H L 0 IMMUNOGLOBULIN 04/26/99 ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, UNLIGANDED FORM MUS MUSCULUS mus musculus mus musculus Pan, Y.H., Amzel, L.M. 2.5 X-RAY DIFFRACTION 0.294 0.192 False False IGHV10 IGKV8 Kappa None None None None None 7n08 C D 0 G peptide NA hiv-1 gp41 immunodominant region IMMUNE SYSTEM 05/25/21 Crystal structure of the 3D6 antibody fragment bound to the HIV-1 gp41 immunodominant region HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 06tg.ht008 Cook, J.D., Lee, J.E. 2.0 X-RAY DIFFRACTION 0.203 0.165 False True IGHV3 IGKV1 Kappa None None None None None 3eyo B A 0 IMMUNE SYSTEM 10/21/08 Crystal structure of anti-human cytomegalovirus antibody 8F9 HOMO SAPIENS homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.5 X-RAY DIFFRACTION 0.268 0.241 False True IGHV3 IGKV3 Kappa None None None None None 7nx2 D C 0 NA NA NA NA PROTEIN BINDING 03/17/21 Unbound antigen-binding fragment (FAb) 324 MUS MUSCULUS mus musculus mus musculus De Munck, S., Savvides, S.N. 1.47 X-RAY DIFFRACTION 0.206 0.168 False True IGHV1 IGKV3 Kappa None None None None None 4ene C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 04/13/12 Structure of the N- and C-terminal trimmed ClC-ec1 Cl-/H+ antiporter and Fab Complex ESCHERICHIA COLI K-12; MUS MUSCULUS mus musculus mus musculus escherichia coli k-12 Hyun-Ho Lim, Shane, T., Miller, C. 2.4 X-RAY DIFFRACTION 0.278 0.239 False True IGHV4 IGKV4 Kappa None None None None None 7phq A C 0 NA NA NA NA MEMBRANE PROTEIN 08/18/21 Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA synthetic construct synthetic construct Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 8.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5ugy H L 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/10/17 Influenza hemagglutinin in complex with a neutralizing antibody INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Whittle, J.R.R., Jenni, S., Harrison, S.C. 2.801 X-RAY DIFFRACTION 0.289 0.259 False True IGHV1 IGLV3 Lambda None None None None None 7fiy N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/01/21 Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus Zhao, F.H., Zhou, Q.T., Cong, Z.T., Hang, K.N., Zou, X.Y., Zhang, C., Chen, Y., Dai, A.T., Liang, A.Y., Ming, Q.Q., Wang, M., Chen, L.N., Xu, P.Y., Chang, R.L., Feng, W.B., Xia, T., Zhang, Y., Wu, B.L., Yang, D.H., Zhao, L.H., Xu, H.E., Wang, M.W. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ns6 S NA 0 M protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/05/21 SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4 vicugna pacos severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Das, H., Hallberg, B.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7e9g F NA 0 S protein NA metabotropic glutamate receptor 2 MEMBRANE PROTEIN 03/04/21 Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Lin, S., Han, S., Zhao, Q., Wu, B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1igf H L 0 IMMUNOGLOBULIN 03/21/91 CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.180 False True IGHV5 IGKV1 Kappa None None None None None 7q0i A B 0 D protein NA spike protein s1 VIRAL PROTEIN 10/14/21 Crystal structure of the N-terminal domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-43 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.39 X-RAY DIFFRACTION 0.242 0.202 False True IGHV3 IGLV3 Lambda None None None None None 4g3y H L 0 C protein tumor necrosis factor IMMUNE SYSTEM 07/15/12 Crystal structure of TNF-alpha in complex with Infliximab Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liang, S.Y., Dai, J.X., Guo, Y.J., Lou, Z.Y. 2.6 X-RAY DIFFRACTION 0.235 0.189 False True IGHV6 IGKV5 Kappa 8.7e-09 -10.996463217420198 SPR TBD 7can A NA 0 B protein NA spike glycoprotein PROTEIN BINDING 06/09/20 Structure of sybody MR17-K99Y in complex with the SARS-CoV-2 S Receptor-binding domain (RBD) SYNTHETIC CONSTRUCT; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 synthetic construct severe acute respiratory syndrome coronavirus2 Li, T., Yao, H., Cai, H., Qin, W., Li, D. 2.94 X-RAY DIFFRACTION 0.267 0.214 False True IGHV1 NA NA None None None None None 7f53 N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/21 Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Zhang, H., Chen, L., Mao, C., Shen, Q., Yang, D., Shen, D., Qin, J. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4tpr H L 0 IMMUNE SYSTEM 06/09/14 Structure of Tau5 antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Cehlar, O., Skrabana, R., Novak, M. 1.6 X-RAY DIFFRACTION 0.191 0.143 False False IGHV14 IGKV1 Kappa None None None None None 6xxp A NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB37, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 1.5 X-RAY DIFFRACTION 0.196 0.172 False True unknown unknown unknown None None None None None 1mcc NA A 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-nh2 IMMUNE SYSTEM 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown 0.199 False True IGLV2 Lambda None None None None None 6o25 A B 0 D | G peptide | protein NA | NA circumsporozoite protein | anti-kappa vhh domain IMMUNE SYSTEM 02/22/19 Crystal structure of 3945 Fab in complex with circumsporozoite protein NANP3 and anti-Kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | lama glama Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.268 0.215 False True IGHV3 IGKV3 Kappa None None None None None 4odw H L 0 IMMUNE SYSTEM 01/10/14 Unliganded Fab structure of lipid A-specific antibody A6 MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.72 X-RAY DIFFRACTION 0.257 0.231 False False IGHV5 IGKV10 Kappa None None None None None 7nd7 J K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6rlo A B 0 I protein NA cd9 antigen IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop HOMO SAPIENS homo sapiens homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.2 X-RAY DIFFRACTION 0.287 0.254 False True IGHV3 IGKV4 Kappa None None None None None 4odv H L 0 L carbohydrate GP1 polysaccharide IMMUNE SYSTEM 01/10/14 Fab Structure of lipid A-specific antibody A6 in complex with lipid A carbohydrate backbone MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.15 X-RAY DIFFRACTION 0.249 0.204 False False IGHV5 IGKV10 Kappa None None None None None 6ss6 I M 0 B protein NA unknown PROTEIN BINDING 09/06/19 Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 3.25 X-RAY DIFFRACTION 0.361 0.300 False False IGHV3 IGLV1 Lambda None None None None None 6udk D E 0 G protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7q9f E F 0 B protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-50 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3j2x F E 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m242 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 15.6 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 2mkw NA A 4 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 7kcr H L 0 C | A | E protein | protein | protein NA | NA | NA envelope protein e | envelope protein e | envelope protein e VIRUS/IMMUNE SYSTEM 10/07/20 Cryo-EM structure of Zika virus in complex with E protein cross-linking human monoclonal antibody ADI30056 HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 | zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 | zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Sevvana, M., Rogers, T.F., Miller, A.S., Long, F., Klose, T., Beutler, N., Lai, Y.C., Parren, M., Walker, L.M., Buda, G., Burton, D.R., Rossmann, M.G., Kuhn, R.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7mjk H I 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7k84 B NA 0 A protein NA botulinum neurotoxin type e ANTITOXIN 09/25/20 Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E5 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.5 X-RAY DIFFRACTION 0.241 0.226 False True IGHV1 NA NA None None None None None 7rky D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/22/21 Binding mode of US27-Gi-scFv16 in OCL-state HOMO SAPIENS; MUS MUSCULUS; HUMAN CYTOMEGALOVIRUS mus musculus homo sapiens | homo sapiens Tsutsumi, N., Jude, K.M., Garcia, K.C. 3.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6pbw D C 0 E peptide npnanpnanpna peptide IMMUNE SYSTEM 06/14/19 Crystal structure of Fab667 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Oyen, D., Wilson, I.A. 2.058 X-RAY DIFFRACTION 0.258 0.202 False True IGHV1 IGLV2 Lambda None None None None None 1ol0 A NA 0 IMMUNOGLOBULIN 08/02/03 Crystal structure of a camelised human VH HOMO SAPIENS homo sapiens Dottorini, T., K Vaughan, C., Walsh, M.A., Losurdo, P., Sollazzo, M. 1.8 X-RAY DIFFRACTION 0.18015 0.15449 False True IGHV3 None None None None None 1s3k H L 0 H carbohydrate FUC polysaccharide IMMUNE SYSTEM 01/13/04 Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide HOMO SAPIENS, MUS MUSCULUS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens homo sapiens, mus musculus mus musculus, homo sapiens Ramsland, P.A., Farrugia, W., Bradford, T.M., Hogarth, P.M., Scott, A.M. 1.9 X-RAY DIFFRACTION 0.238 0.203 False True IGHV3 IGKV1 Kappa 2.4e-07 -9.031007686639388 Unknown TBD 4m1c E F 0 B protein insulin-degrading enzyme HYDROLASE 08/02/13 Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens McCord, L.M., Liang, W., Farcasanu, M., Scherpelz, K., Meredith, S.C., Koide, S., Tang, W.J. 3.5007 X-RAY DIFFRACTION 0.270 0.228 False True IGHV3 IGKV1 Kappa None None None None None 6v8x G H 0 E protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 5mp5 E F 0 I peptide microtubule-associated protein tau IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M. 2.31 X-RAY DIFFRACTION 0.277 0.235 False False IGHV1 IGKV8 Kappa None None None None None 6mdt D E 0 B protein transmembrane protein gp41 VIRAL PROTEIN 09/05/18 Crystal structure of the B41 SOSIP.664 Env trimer with PGT124 and 35O22 Fabs, in P63 space group HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Sarkar, A., Wilson, I.A. 3.816 X-RAY DIFFRACTION 0.311 0.294 False True unknown unknown unknown None None None None None 6woz E F 0 D protein NA reticulocyte binding protein 2b CELL INVASION 04/26/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 251249 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.258 0.211 False True IGHV3 IGKV3 Kappa None None None None None 7c81 H L 0 A | C protein | protein NA | NA vp1 | vp3 VIRUS/IMMUNE SYSTEM 05/28/20 E30 F-particle in complex with 6C5 ECHOVIRUS E30; MUS MUSCULUS mus musculus mus musculus echovirus e30 | echovirus e30 Wang, K., Zheng, B., Zhang, L., Cui, L., Su, X., Zhang, Q., Guo, Y., Zhu, L., Zhu, F., Rao, Z., Wang, X. 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 7lsf H L 0 E protein NA envelope protein e IMMUNE SYSTEM/VIRAL PROTEIN 02/18/21 Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Western Subtype) HOMO SAPIENS; TICK-BORNE ENCEPHALITIS VIRUS (WESTERN SUBTYPE) homo sapiens homo sapiens tick-borne encephalitis virus (westernsubtype) Keeffe, J.R., Bjorkman, P.J. 2.24 X-RAY DIFFRACTION 0.227 0.189 False True IGHV3 IGKV3 Kappa None None None None None 6bzw C D 0 I peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody AP33 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.2 X-RAY DIFFRACTION 0.231 0.192 False True IGHV3 IGKV3 Kappa None None None None None 7k5x N n 0 G | F | H protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of a chromatosome containing human linker histone H1.0 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 2.93 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6uup D d 0 NA NA NA NA ANTITUMOR PROTEIN 10/31/19 Structure of anti-hCD33 conditional scFv CAMELIDAE MIXED LIBRARY camelidae mixed library Kimberlin, C.R., Park, S. 2.20002 X-RAY DIFFRACTION 0.237 0.197 True True unknown unknown unknown None None None None None 7sg4 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/04/21 Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Gobeil, S., Acharya, P. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 4py7 A B 0 IMMUNE SYSTEM 03/26/14 Crystal Structure of Fab 3.1 HOMO SAPIENS homo sapiens homo sapiens Dreyfus, C. 2.7 X-RAY DIFFRACTION 0.273 0.228 False True IGHV3 IGKV1 Kappa None None None None None 3wbd B b 0 IMMUNE SYSTEM 05/14/13 Crystal structure of anti-polysialic acid antibody single chain Fv fragment (mAb735) complexed with octasialic acid SYNTHETIC CONSTRUCT synthetic construct Nagae, M., Ikeda, A., Hanashima, S., Kitajima, K., Sato, C., Yamaguchi, Y. 1.8 X-RAY DIFFRACTION 0.259 0.233 True True unknown unknown unknown None None None None None 7shu E F 0 B protein NA immunoglobulin heavy constant epsilon IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with omalizumab variant C02 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 2.75 X-RAY DIFFRACTION 0.275 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7kzb A B 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/10/20 Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.83 X-RAY DIFFRACTION 0.336 0.251 False True IGHV5 IGKV1 Kappa None None None None None 6chb M N 0 F protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 6.801 X-RAY DIFFRACTION 0.417 0.318 False True IGHV1 IGLV2 Lambda None None None None None 1um5 H L 0 H Hapten SS1 1-PHENYLETHANOL IMMUNE SYSTEM 09/23/03 Catalytic Antibody 21H3 with alcohol substrate MUS MUSCULUS mus musculus mus musculus mus musculus Beuscher IV, A.E., Reuter, J., Olson, A.J., Romesberg, F.E., Schultz, P.G., Wirsching, P., Janda, K.D., Lerner, R.A., Stevens, R.C. 1.6 X-RAY DIFFRACTION 0.246 0.205 False True IGHV1 IGKV9 Kappa None None None None None 7tqa H L 0 NA NA NA NA IMMUNE SYSTEM 01/26/22 Crystal Structure of monoclonal S9.6 Fab SYNTHETIC CONSTRUCT synthetic construct synthetic construct Bou Nader, C., Zhang, J. 2.328 X-RAY DIFFRACTION 0.235 0.179 False True IGHV1 IGKV1 Kappa None None None None None 7x7e B NA 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 SARS-CoV-2 RBD and Nb22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA lama severe acute respiratory syndrome coronavirus2 Wang, Y., Ye, S. 2.67 X-RAY DIFFRACTION 0.250 0.205 False True IGHV1 NA NA None None None None None 5b3j H L 0 D protein glutamate receptor ionotropic, nmda 2b TRANSPORT PROTEIN 03/01/16 Activation of NMDA receptors and the mechanism of inhibition by ifenprodil RATTUS NORVEGICUS; XENOPUS LAEVIS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Karakas, E., Grant, T., Simorowski, N., Diaz-Avalos, R., Grigorieff, N., Furukawa, H. 2.9 X-RAY DIFFRACTION 0.302 0.273 False False IGHV5 IGKV19 Kappa None None None None None 6x7w A C 0 D peptide NA hiv fusion peptide 512-519 IMMUNE SYSTEM/VIRAL PROTEIN 05/30/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP49.02 in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.248 0.214 False True IGHV5 IGKV5 Kappa None None None None None 6qv1 E NA 0 B | A protein | protein NA | NA uncharacterized abc transporter atp-binding proteintm_0288 | abc transporter, atp-binding protein MEMBRANE PROTEIN 03/01/19 Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM1 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); VICUGNA PACOS vicugna pacos thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) | thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 3.48 X-RAY DIFFRACTION 0.303 0.267 False True IGHV1 NA NA None None None None None 5ysl G H 0 IMMUNE SYSTEM 11/14/17 Crystal structure of antibody 1H1 Fab MUS MUSCULUS mus musculus mus musculus Hu, X.L., Yang, F.L. 2.5 X-RAY DIFFRACTION 0.273 0.212 False True IGHV1 IGKV4 Kappa None None None None None 4lvh H I 0 G protein hemagglutinin IMMUNE SYSTEM 07/26/13 Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J.-H. 2.8 X-RAY DIFFRACTION 0.274 0.232 False False IGHV5 IGKV3 Kappa None None None None None 5uk0 I i 0 E protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 2 HOMO SAPIENS; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 4unu NA B 0 IMMUNE SYSTEM 05/30/14 MCG - a dimer of lambda variable domains HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C., Whitelegge, J., Casio, D., Sawaya, M.R., Eisenberg, D.S. 0.95 X-RAY DIFFRACTION 0.12996 0.10731 False True IGLV2 Lambda None None None None None 6h6y H NA 0 D protein capsid protein vp1 VIRAL PROTEIN 12/19/18 GI.1 human norovirus protruding domain in complex with Nano-7 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Ruoff, K., Hansman, G.S. 1.58 X-RAY DIFFRACTION 0.175 0.155 False True IGHV1 None None None None None 5a7x H G 0 E protein hiv-1 yu2 gp120 VIRAL PROTEIN 07/10/15 negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 17.0 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7apj B NA 0 A protein NA rac-alpha serine/threonine-protein kinase,non-specificserine/threonine protein kinase,rac-alpha serine/threonine-protein kinase SIGNALING PROTEIN 10/16/20 Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation HOMO SAPIENS; DANIO RERIO; LAMA GLAMA lama glama homo sapiens, danio rerio Truebestein, L., Hornegger, H., Leonard, T.A. 2.05 X-RAY DIFFRACTION 0.252 0.211 False True IGHV1 NA NA None None None None None 7m6e F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, BG10-19 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 5nml D NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 7zmv G NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.002 X-RAY DIFFRACTION 0.275 0.242 False True IGHV1 NA NA None None None None None 2q8a H L 0 A protein apical membrane antigen 1 Immune System 06/10/07 Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Gupta, A., Murphy, V.J., Anders, R.F., Batchelor, A.H. 2.4 X-RAY DIFFRACTION 0.244 0.202 False False IGHV14 IGKV6 Kappa None None None None None 6tkf H L 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 ChiLob 7/4 H2 HC-C225S KappaLC-C214S F(ab')2 HOMO SAPIENS Orr, C.M., Fisher, H., Tews, I. 2.18 X-RAY DIFFRACTION 0.239 0.196 False False IGHV1 IGKV10 Kappa None None None None None 1kb9 J K 0 E protein ubiquinol-cytochrome c reductase iron-sulfur subunit OXIDOREDUCTASE/ELECTRON TRANSPORT 11/05/01 YEAST CYTOCHROME BC1 COMPLEX SACCHAROMYCES CEREVISIAE; MUS MUSCULUS mus musculus mus musculus saccharomyces cerevisiae Lange, C., Nett, J.H., Trumpower, B.L., Hunte, C. 2.3 X-RAY DIFFRACTION 0.249 0.218 False True IGHV3 IGKV10 Kappa None None None None None 6vmk M L 0 W protein NA complement factor d HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 7kkj A NA 0 NA NA NA NA IMMUNE SYSTEM 10/27/20 Structure of anti-SARS-CoV-2 Spike nanobody mNb6 SYNTHETIC CONSTRUCT synthetic construct Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 2.05 X-RAY DIFFRACTION 0.248 0.212 False True IGHV1 NA NA None None None None None 4llv A B 0 IMMUNE SYSTEM 07/09/13 The structure of the unbound form of anti-HIV antibody 4E10 Fv HOMO SAPIENS homo sapiens homo sapiens Finton, K.A.K., Rupert, P.B., Strong, R.K. 2.39 X-RAY DIFFRACTION 0.245 0.216 False True IGHV1 IGKV3 Kappa None None None None None 6p4b B A 0 D protein lysozyme c HYDROLASE/IMMUNE SYSTEM 05/27/20 HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S) MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.244 0.203 False True IGHV3 IGKV5 Kappa None None None None None 6d2p H L 0 C protein germline-targeting hiv-1 gp120 engineered outer domain eod-gt8 IMMUNE SYSTEM 04/13/18 Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sarkar, A., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.268 0.213 False True IGHV1 IGLV2 Lambda None None None None None 7qn9 L NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state HOMO SAPIENS homo sapiens homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3ncy P S 0 B | A protein | protein NA | NA adic | adic TRANSPORT PROTEIN 06/06/10 X-ray crystal structure of an arginine agmatine antiporter (AdiC) in complex with a Fab fragment SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; MUS MUSCULUS mus musculus mus musculus salmonella enterica subsp. enterica serovartyphimurium | salmonella enterica subsp. enterica serovartyphimurium Fang, Y., Jayaram, H., Shane, T., Komalkova-Partensky, L., Wu, F., Williams, C., Xiong, Y., Miller, C. 3.2 X-RAY DIFFRACTION 0.312 0.282 False True IGHV1 IGKV4 Kappa None None None None None 2kqm NA B 4 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6u59 H L 0 A protein sosip.664 gp120,sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/27/19 HIV-1 B41 SOSIP.664 in complex with rabbit antibody 13B HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Yang, Y.R., Ward, A.B. 3.86 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7d3m H L 0 1 | 3 protein | protein NA | NA o/tibet/99 vp1 | o/tibet/99 vp3 VIRUS 09/19/20 FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY R50 BOS TAURUS; FOOT-AND-MOUTH DISEASE VIRUS bos taurus bos taurus foot-and-mouth disease virus | foot-and-mouth disease virus He, Y., Lou, Z. 3.94 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5xp1 NA C 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 5tr8 H L 0 IMMUNE SYSTEM 10/25/16 Crystal structure of vaccine-elicited pan- influenza H1N1 neutralizing murine antibody 441D6. MUS; MUS MUSCULUS mus, mus musculus mus, mus musculus Joyce, M.G., Kanekiyo, M., Mascola, J.R., Graham, B.S., Kwong, P.D. 2.01 X-RAY DIFFRACTION 0.198 0.174 False True IGHV5 IGKV14 Kappa None None None None None 5dxw A NA 0 SIGNALING PROTEIN 09/24/15 Crystal structure of mouse PD-L1 nanobody MUS MUSCULUS mus musculus Fedorov, A.A., Fedorov, E.V., Samanta, D., Almo, S.C. 1.441 X-RAY DIFFRACTION 0.193 0.169 False True IGHV1 None None None None None 3cxh U V 0 P protein cytochrome b-c1 complex subunit rieske,mitochondrial OXIDOREDUCTASE 04/24/08 Structure of yeast complex III with isoform-2 cytochrome c bound and definition of a minimal core interface for electron transfer. MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Solmaz, S.R.N., Hunte, C. 2.5 X-RAY DIFFRACTION 0.256 0.225 False True IGHV3 IGKV10 Kappa None None None None None 5v8m R T 0 F protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/22/17 A broadly neutralizing antibody targets the dynamic HIV Envelope trimer apex via a long, rigidified, and anionic beta-hairpin structure HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Cottrell, C.A., Ward, A.B. 4.4 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 6nc2 S X 0 N | G protein | protein NA | NA amc011 v4.2 sosip gp41 | amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B. 5.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3juy D d 0 IMMUNE SYSTEM 09/15/09 Crystal Structure of a 3B3 Variant, a Broadly Neutralizing HIV-1 scFv Antibody HOMO SAPIENS homo sapiens Clark, K.R., Walsh, S.T. 2.5 X-RAY DIFFRACTION 0.260 0.195 True True unknown unknown unknown None None None None None 5ihl E NA 0 D protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 02/29/16 STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB HOMO SAPIENS homo sapiens homo sapiens Sheriff, S. 3.3 X-RAY DIFFRACTION 0.298 0.268 False True IGHV3 None None None None None 5iq7 H L 0 P peptide gp41 mper peptide IMMUNE SYSTEM 03/10/16 Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Kwon, Y.D., Caruso, W., Kwong, P.D. 3.2869 X-RAY DIFFRACTION 0.282 0.230 False True IGHV3 IGLV3 Lambda None None None None None 7f6z H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Complex Structure of antibody BD-503 and RBD-501Y.V2 of COVID-19 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xu, H., Wang, B., Zhao, T.N., Su, X.D. 3 X-RAY DIFFRACTION 0.254 0.207 False True IGHV3 IGKV1 Kappa None None None None None 6svl A B 0 C protein myeloid-derived growth factor CYTOKINE 09/18/19 human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ebenhoch, R., Nar, H. 1.58 X-RAY DIFFRACTION 0.206 0.181 False True IGHV14 IGKV12 Kappa None None None None None 5vm4 F NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 2kqn NA B 5 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6l8t A B 0 IMMUNE SYSTEM 11/07/19 Crystal structure of the Fab fragment of a humanized HBV therapeutic antibody HOMO SAPIENS homo sapiens homo sapiens He, M.Z., Gu, Y., Li, S.W. 1.766 X-RAY DIFFRACTION 0.192 0.165 False True IGHV3 IGKV1 Kappa None None None None None 1cic B A 0 IMMUNOGLOBULIN 03/31/99 IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225 MUS MUSCULUS mus musculus mus musculus Bentley, G.A. 2.5 X-RAY DIFFRACTION unknown 0.179 False False IGHV1 IGKV6 Kappa None None None None None 4lhq B NA 0 A protein NA ricin HYDROLASE/IMMUNE SYSTEM 07/01/13 Ricin A chain bound to camelid nanobody (VHH8) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Cheung, J., Franklin, M., Burshteyn, F., Cassidy, M., Gary, E., Mantis, N. 2.3 X-RAY DIFFRACTION 0.248 0.192 False True IGHV1 NA NA None None None None None 6zh9 H L 0 E protein NA unknown ANTIVIRAL PROTEIN 06/21/20 Ternary complex CR3022 H11-H4 and RBD (SARS-CoV-2) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H., Le Bas, A. 3.31 X-RAY DIFFRACTION 0.305 0.261 False False IGHV5 IGKV4 Kappa None None None None None 6blh H L 0 G peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/10/17 RSV G central conserved region bound to Fab CB017.5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human respiratory syncytial virus a (strainrsb6256) Jones, H.G., McLellan, J.S., Langedijk, J.P. 2.0 X-RAY DIFFRACTION 0.226 0.187 False True IGHV3 IGLV3 Lambda 4.0999999999999995e-09 -11.442210050076369 Unknown TBD 3eo1 K J 0 L protein transforming growth factor beta-3 IMMUNE SYSTEM/CYTOKINE 09/26/08 Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Gruetter, C., Gruetter, M.G. 3.1 X-RAY DIFFRACTION 0.279 0.255 False True IGHV1 IGKV8 Kappa 2.50e-10 -13.09 Other 19073914 4r0l H L 0 D protein t-cell costimulatory molecule cd28 IMMUNE SYSTEM 07/31/14 Anti-canine CD28 antibody, 1C6, bound canine CD28 CANIS LUPUS FAMILIARIS; MUS MUSCULUS mus musculus canis lupus familiaris mus musculus Gewe, M.M., Strong, R.K. 3.3 X-RAY DIFFRACTION 0.293 0.256 False True IGHV9 IGKV2 Kappa None None None None None 6pyc NA H 0 L Hapten P4S (3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide IMMUNE SYSTEM 07/29/19 Structure of kappa-on-heavy (KoH) antibody Fab bound to the cardiac hormone marinobufagenin MUS MUSCULUS mus musculus mus musculus Franklin, M.C., Macdonald, L.E., McWhirter, J., Murphy, A.J. 3.6 X-RAY DIFFRACTION 0.287 0.234 False True IGKV4 Kappa None None None None None 5jsa E F 0 C | D protein | protein NA | NA gp120 | gp41 VIRAL PROTEIN/IMMUNE SYSTEM 05/07/16 Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Kong, L., Wilson, I.A. 6.308 X-RAY DIFFRACTION 0.322 0.281 False True unknown IGKV1 Kappa None None None None None 7dzy H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 01/26/21 Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 2490 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Y., Soh, W.T., Li, S., Kishikawa, J., Hirose, M., Kato, T., Standley, D., Okada, M., Arase, H. 3.6 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV3 IGKV3 Kappa None None None None None 6h7n D NA 0 B protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G. 2.5 X-RAY DIFFRACTION 0.266 0.248 False True IGHV1 3.5000000000000003e-09 -11.535955190950428 Unknown TBD 3j2x H G 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m242 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 15.6 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 3pho B A 0 A Hapten KD1 3-DEOXY-ALPHA-D-MANNO-OCT-2-ULOPYRANONOSYL-(2->8)-3-DEOXY-ALPHA-D-MANNO-OCT-2-ULOPYRANONOSYL-(2->4)-3-DEOXY-ALPHA-D-MANNO-OCT-2-ULOPYRANONOSYL-(2->6)-2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE CARBOHYDRATE-BINDING PROTEIN 11/04/10 Crystal structure of S64-4 in complex with PSBP MUS MUSCULUS mus musculus mus musculus mus musculus Evans, D.W., Evans, S.V. 2.6 X-RAY DIFFRACTION 0.275 0.219 False False IGHV7 IGKV3 Kappa None None None None None 6v4r H L 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 Crystal structure of a chimeric MR78-like antibody chimera-1 Fab HOMO SAPIENS homo sapiens homo sapiens Bozhanova, N.G., Crowe, J.E., Meiler, J. 3.48 X-RAY DIFFRACTION 0.327 0.295 False True IGHV4 IGKV1 Kappa None None None None None 2kh2 B b 74 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6ujc E F 0 B | A protein | protein NA | NA integrin beta-8 | integrin alpha-v SIGNALING PROTEIN/IMMUNE SYSTEM 10/02/19 Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Campbell, M.G., Cormier, A., Cheng, Y., Nishimura, S.L. 3.56 ELECTRON MICROSCOPY False True IGHV9 IGKV8 Kappa None None None None None 6ous W X 0 L | K protein | protein NA | NA fusion glycoprotein f1 fused with fibritin trimerizationdomain | fusion glycoprotein f2 VIRAL PROTEIN/Immune system 05/05/19 Structure of fusion glycoprotein from human respiratory syncytial virus HUMAN RESPIRATORY SYNCYTIAL VIRUS A2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a2, humanimmunodeficiency virus 1 | human respiratory syncytial virus a2 Su, H.P. 3.4 X-RAY DIFFRACTION 0.275 0.245 False True IGHV3 IGKV1 Kappa None None None None None 7omm C NA 0 A | B protein | protein NA | NA lps-assembly protein lptd | lps-assembly lipoprotein lpte TRANSPORT PROTEIN 05/24/21 Cryo-EM structure of N. gonorhoeae LptDE in complex with ProMacrobodies (MBPs have not been built de novo) NEISSERIA GONORRHOEAE; SYNTHETIC CONSTRUCT; METHANOSARCINA MAZEI synthetic construct, methanosarcina mazei neisseria gonorrhoeae | neisseria gonorrhoeae Botte, M., Ni, D., Schenck, S., Zimmermann, I., Chami, M., Bocquet, N., Egloff, P., Bucher, D., Trabuco, M., Cheng, R.K.Y., Brunner, J.D., Seeger, M.A., Stahlberg, H., Hennig, M. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5tok F NA 0 C protein fusion glycoprotein f0, fibritin chimera VIRAL PROTEIN/IMMUNE SYSTEM 10/17/16 Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66 HUMAN RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama human respiratory syncytial virus Gilman, M.S.A., Kabeche, S.C., McLellan, J.S. 3.8 X-RAY DIFFRACTION 0.286 0.248 False True IGHV1 None None None None None 7kqy B NA 0 NA NA NA NA IMMUNE SYSTEM 11/18/20 Crystal Structure and Characterization of Human Heavy-Chain only Antibodies reveals a novel, stable dimeric structure similar to Monoclonal Antibodies HOMO SAPIENS homo sapiens Bahmanjah, S., Mieczkowski, C., Yu, Y., Baker, J., Raghunathan, G., Tomazela, D., Hsieh, M., Mccoy, M., Strickland, C., Fayadat-Dilman, L. 2.913 X-RAY DIFFRACTION 0.260 0.207 False True IGHV1 NA NA None None None None None 5wux C D 0 G protein tumor necrosis factor alpha IMMUNE SYSTEM 12/21/16 TNFalpha-certolizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, J.U. 2.9 X-RAY DIFFRACTION 0.266 0.226 False True IGHV3 IGKV1 Kappa 2.7399999999999997e-11 -14.40948636554907 SPR TBD 4eiz C NA 0 B protein dihydrofolate reductase OXIDOREDUCTASE/IMMUNE SYSTEM 04/06/12 Structure of Nb113 bound to apoDHFR ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Oyen, D., Srinivasan, V. 2.2 X-RAY DIFFRACTION 0.224 0.171 False True IGHV1 3.0000000000000004e-09 -11.627286953008985 SPR TBD 6xc2 X Y 0 Z protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 3.112 X-RAY DIFFRACTION 0.267 0.213 False True IGHV3 IGKV1 Kappa None None None None None 2wub R Q 0 C protein hepatocyte growth factor activator long chain HYDROLASE/IMMUNE SYSTEM 10/01/09 Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ganesan, R., Eigenbrot, C., Shia, S., , 2.9 X-RAY DIFFRACTION 0.275 0.216 False True IGHV3 IGKV1 Kappa 1.50e-07 -9.3 SPR 25 20004165 3hae O N 0 J | M protein | peptide NA | NA hla class i histocompatibility antigen, a-2 alpha chain | nyeso-1 peptide IMMUNE SYSTEM 05/01/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E. 2.9 X-RAY DIFFRACTION 0.283 0.201 False True IGHV3 IGLV2 Lambda 4.60e-08 -10 SPR 19307587 4qth A B 0 IMMUNE SYSTEM 07/08/14 Crystal structure of anti-uPAR Fab 8B12 MUS MUSCULUS mus musculus mus musculus Zhao, B., Yuan, C., Luo, Z., Huang, M. 2.17 X-RAY DIFFRACTION 0.273 0.229 False False IGHV1 IGKV9 Kappa None None None None None 7k8v M N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C110 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dam, K.A., Barnes, C.O., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 2vdk H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Re-refinement of Integrin AlphaIIbBeta3 Headpiece HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.8 X-RAY DIFFRACTION 0.205 0.161 False False IGHV14 IGKV14 Kappa None None None None None 6u59 K J 0 G protein sosip.664 gp120,sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/27/19 HIV-1 B41 SOSIP.664 in complex with rabbit antibody 13B HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Yang, Y.R., Ward, A.B. 3.86 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 4ncc H L 0 IMMUNE SYSTEM 10/24/13 Neutralizing antibody to murine norovirus MUS MUSCULUS mus musculus mus musculus Smith, T., Li, M. 2.49 X-RAY DIFFRACTION 0.273 0.204 False False IGHV4 IGKV4 Kappa None None None None None 7z0x H L 0 R protein NA surface glycoprotein ANTIVIRAL PROTEIN 02/23/22 THSC20.HVTR26 Fab bound to SARS-CoV-2 Receptor Binding Domain HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wibmer, C.K. 1.8 X-RAY DIFFRACTION 0.188 0.163 False True IGHV3 IGLV2 Lambda None None None None None 3v52 H L 0 P peptide h-2 class i histocompatibility antigen, l-d alpha chain IMMUNE SYSTEM 12/15/11 Structure of a monoclonal antibody complexed with its MHC-I antigen MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Mage, M.G., Dolan, M.A., Wang, R., Boyd, L.F., Revilleza, M.J., Robinson, H., Natarajan, K., Myers, N.B., Hansen, T.H., Margulies, D.H. 1.697 X-RAY DIFFRACTION 0.227 0.197 False False IGHV5 IGKV1 Kappa None None None None None 7a5s I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/21/20 Complex of SARS-CoV-2 spike and CR3022 Fab (Homogeneous Refinement) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 1n64 H L 0 P peptide genome polyprotein capsid protein c IMMUNE SYSTEM 11/08/02 Crystal structure analysis of the immunodominant antigenic site on Hepatitis C virus protein bound to mAb 19D9D6 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus Menez, R., Bossus, M., Muller, B., Sibai, G., Dalbon, P., Ducancel, F., Jolivet-Reynaud, C., Stura, E. 2.34 X-RAY DIFFRACTION 0.245 0.190 False True IGHV9 IGKV8 Kappa 1.30e-09 -12.12 SPR 12574359 3j70 M N 0 P protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/22/14 Model of gp120, including variable regions, in complex with CD4 and 17b HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Rasheed, M., Bettadapura, R., Bajaj, C. NOT ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 7nvm N NA 0 E protein NA t-complex protein 1 subunit epsilon CHAPERONE 03/15/21 Human TRiC complex in closed state with nanobody Nb18, actin and PhLP2A bound HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W., Structural Genomics Consortium (SGC) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6ba5 F E 0 O protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/12/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.62 X-RAY DIFFRACTION 0.214 0.194 False True IGHV1 IGKV1 Kappa None None None None None 6k2i A NA 12 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7mnl H L 0 A protein NA e3 sumo-protein ligase ranbp2 TRANSFERASE/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 3.95 X-RAY DIFFRACTION 0.241 0.192 False True IGHV3 IGKV1 Kappa None None None None None 6jjp D E 0 F protein programmed cell death protein 1 IMMUNE SYSTEM 02/26/19 Crystal structure of Fab of a PD-1 monoclonal antibody MW11-h317 in complex with PD-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, M., Wang, J., Wang, R., Jiao, S., Wang, S., Zhang, J., Zhang, M. 2.9 X-RAY DIFFRACTION 0.247 0.207 False True IGHV3 IGKV2 Kappa None None None None None 5mu0 A B 0 Q peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 5fv1 NA L 0 V protein vascular endothelial growth factor a 02/02/16 Crystal structure of hVEGF in complex with VK domain antibody HOMO SAPIENS homo sapiens homo sapiens Chung, C., Walker, A. 2.7 X-RAY DIFFRACTION 0.26056 0.20536 False True IGKV1 Kappa None None None None None 4y5v D E 0 F protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 2.604 X-RAY DIFFRACTION 0.229 0.187 False True IGHV3 IGLV2 Lambda None None None None None 4bfb E NA 0 B protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 03/18/13 BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 2.21 X-RAY DIFFRACTION 0.27320 0.20370 False True IGHV3 None None None None None 6z3k G I 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 6bfq H L 0 K protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 10/26/17 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W. 2.6 X-RAY DIFFRACTION 0.264 0.230 False True IGHV4 IGKV1 Kappa None None None None None 1ngx B A 0 B Hapten JEF JEFFAMINE IMMUNE SYSTEM 12/18/02 Chimeric Germline Fab 7g12 with jeffamine fragment bound MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Yin, J., Andryski, S.E., Beuscher, A.B., Stevens, R.C., Schultz, P.G. 1.8 X-RAY DIFFRACTION 0.250 0.225 False True IGHV1 IGKV6 Kappa None None None None None 7sg6 H L 0 A peptide NA pfcsp peptide 21 IMMUNE SYSTEM 10/05/21 Structure of PfCSP peptide 21 with antibody CIS43_Var10 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Tripathi, P., Kwong, P.D. 1.55 X-RAY DIFFRACTION 0.211 0.184 False True IGHV1 IGKV4 Kappa None None None None None 7k8z M N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C135 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6vtw H L 0 A peptide s4_2.45 IMMUNE SYSTEM 02/13/20 Crystal Structure of a computationally designed Immunogen S4_2.45 in complex with 101F MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human respiratory syncytial virus a2 Jardetzky, T., Correia, B. 2.6 X-RAY DIFFRACTION 0.283 0.207 False True IGHV8 IGKV3 Kappa None None None None None 7rfb A B 0 C protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 07/14/21 Crystal structure of broadly neutralizing antibody mAb1198 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain HOMO SAPIENS; HEPACIVIRUS C homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 2.7 X-RAY DIFFRACTION 0.262 0.215 False True IGHV1 IGKV2 Kappa None None None None None 1lo2 H L 0 H Hapten OX1 ? IMMUNE SYSTEM 05/06/02 Retro-Diels-Alderase Catalytic Antibody MUS MUSCULUS mus musculus mus musculus mus musculus Hugot, M., Reymond, J.L., Baumann, U. 2.0 X-RAY DIFFRACTION 0.248 0.210 False False IGHV5 IGKV1 Kappa None None None None None 7azb B NA 0 A protein NA discoidin domain-containing receptor 2 MEMBRANE PROTEIN 11/16/20 Structure of DDR2 DS domain in complex with VHH HOMO SAPIENS homo sapiens homo sapiens Talagas, A., Nawrotek, A., Arrial, A., Vuillard, L.M., Miallau, L. 2.62 X-RAY DIFFRACTION 0.299 0.210 False True IGHV3 NA NA None None None None None 5udd O U 0 I protein NA fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F B9320 Bound to MEDI8897 HUMAN RESPIRATORY SYNCYTIAL VIRUS 9320; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus 9320 McLellan, J.S. 4.3 X-RAY DIFFRACTION 0.295 0.237 False True IGHV1 IGKV1 Kappa None None None None None 1pw3 NA B 0 IMMUNE SYSTEM 06/30/03 Crystal structure of JtoR68S HOMO SAPIENS homo sapiens Dealwis, C., Gupta, V., Wilkerson, M. 1.9 X-RAY DIFFRACTION 0.233 0.219 False True IGLV6 Lambda None None None None None 1nak H L 0 P peptide peptide mp1 IMMUNE SYSTEM 11/27/02 IGG1 FAB FRAGMENT (83.1) COMPLEX WITH 16-RESIDUE PEPTIDE (RESIDUES 304-321 OF HIV-1 GP120 (MN ISOLATE)) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Ghiara, J.B., Ollmann Saphire, E., Profy, A.T., Wilson, I.A. 2.57 X-RAY DIFFRACTION 0.326 0.288 False False IGHV3 IGKV1 Kappa None None None None None 7mfa G I 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA+P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.286 0.238 False True IGHV3 IGLV3 Lambda None None None None None 3hc0 H L 0 IMMUNE SYSTEM 05/05/09 BHA10 IgG1 wild-type Fab - antibody directed at human LTBR HOMO SAPIENS homo sapiens homo sapiens Arndt, J.W., Jordan, J.L., Lugovskoy, A., Wang, D. 1.9 X-RAY DIFFRACTION 0.206 0.180 False True IGHV1 IGKV1 Kappa None None None None None 4jzn A B 0 immune system/viral protein 04/03/13 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Krey, T., Rey, F.A. 2.05 X-RAY DIFFRACTION 0.235 0.198 False True IGHV1 IGLV3 Lambda None None None None None 7sfw Q R 0 H protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 (focus refine of the asymmetric unit) VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 7n5h H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/21 Cryo-EM structure of broadly neutralizing antibody 2-36 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Cerutti, G., Shapiro, L. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 6ol6 A B 0 IMMUNE SYSTEM 04/15/19 Structure of iglb12 scFv in complex with anti-idiotype ib2 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M., Gewe, M. 2.6 X-RAY DIFFRACTION 0.231 0.171 False True IGHV1 IGKV6 Kappa None None None None None 7rfb H L 0 D protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 07/14/21 Crystal structure of broadly neutralizing antibody mAb1198 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain HOMO SAPIENS; HEPACIVIRUS C homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 2.7 X-RAY DIFFRACTION 0.262 0.215 False True IGHV1 IGKV2 Kappa None None None None None 6qtl C NA 0 A Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 6osy P O 0 K protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6v4n H L 0 N protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 1G05 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6mn7 G g 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN 10/01/18 Cryo-EM structure of BG505.SOSIP.664 in complex with BF520.1 antigen binding fragment HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens human immunodeficiency virus 1 Williams, J.A., Lee, K.K., Overbaugh, J. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6j15 H L 0 D protein programmed cell death protein 1 IMMUNE SYSTEM 12/27/18 Complex structure of GY-5 Fab and PD-1 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Chen, D., Tan, S., Zhang, H., Wang, H., Chai, Y., Qi, J., Yan, J., Gao, G.F. 2.6 X-RAY DIFFRACTION 0.277 0.212 False False IGHV1 IGKV1 Kappa None None None None None 5acm NA B 0 A Hapten MBT 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM 08/17/15 Mcg immunoglobulin variable domain with methylene blue HOMO SAPIENS homo sapiens homo sapiens Brumshtein, B., Esswein, S.R., Salwinski, L., Phillips, M.L., Ly, A.T., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 1.05 X-RAY DIFFRACTION 0.12234 0.11033 False True IGLV2 Lambda None None None None None 4jpw H L 0 G protein hiv-1 clade a/e strain 73th057 gp120 with mutation h375s viral protein/immune system 03/19/13 Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Luongo, T., Zhou, T., Kwong, P.D. 2.904 X-RAY DIFFRACTION 0.265 0.206 False True IGHV1 IGKV1 Kappa None None None None None 7qjj B NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of a Mn2+ soak of EleNRMT in complex with two Nanobodies at 4.6A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.6 X-RAY DIFFRACTION 0.327 0.284 False True IGHV1 NA NA None None None None None 5v7r H L 0 IMMUNE SYSTEM 03/20/17 Cyrstal structure of anti-Tau antibody CBTAU-7.1 Fab HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Zhang, H., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.224 0.171 False True IGHV3 IGKV3 Kappa None None None None None 6q0o Z B 0 A protein hemagglutinin head domain IMMUNE SYSTEM 08/02/19 human antibody H2227 lineage 652 in complex with influenza hemagglutinin head domain of A/Solomon Islands/3/2006(H1N1) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus McCarthy, K.R., Harrison, S.C. 3.0 X-RAY DIFFRACTION 0.268 0.230 False True IGHV4 IGLV3 Lambda None None None None None 7m7b H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/27/21 SARS-CoV-2 Spike:Fab 3D11 complex focused refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Asarnow, D., Cheng, Y. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 7p40 F B 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/09/21 P5C3 is a potent fab neutralizer SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 perez, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6iyn A NA 17 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 4rqq B A 0 IMMUNE SYSTEM 11/04/14 Crystal structure of human Fab PGDM1400, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.253 0.221 False True unknown IGKV2 Kappa None None None None None 4yxk H L 0 A protein major prion protein IMMUNE SYSTEM 03/23/15 Crystal structure of Elk prion protein complexed with POM1 FAB MUS MUSCULUS; CERVUS ELAPHUS NELSONI mus musculus mus musculus cervus elaphus nelsoni Baral, P.K., Swayampakula, M., James, M.N.G. 2.805 X-RAY DIFFRACTION 0.353 0.300 False True IGHV1 IGKV5 Kappa None None None None None 6nfn H L 0 L Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 4hkb G H 0 IMMUNE SYSTEM 10/15/12 CH67 Fab (unbound) from the CH65-67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 3.6 X-RAY DIFFRACTION 0.306 0.258 False True IGHV1 IGLV3 Lambda None None None None None 7tfn I J 0 B protein NA envelope glycoprotein bg505 sosip.664 - gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/06/22 Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV4 Lambda None None None None None 4s10 A NA 0 C protein gelsolin METAL BINDING PROTEIN/IMMUNE SYSTEM 01/07/15 Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Wongsantichon, J., Robinson, R.C., Gettemans, J. 2.614 X-RAY DIFFRACTION 0.312 0.223 False True IGHV1 None None None None None 4nnp X Y 0 B protein lipoprotein TRANSPORT PROTEIN/IMMUNE SYSTEM 11/18/13 Crystal Structure of Apo Manganese ABC transporter MntC from Staphylococcus aureus bound to an antagonistic fab fragment HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS homo sapiens homo sapiens staphylococcus aureus subsp. aureus Rouge, L., Sudhamsu, J. 2.69 X-RAY DIFFRACTION 0.283 0.224 False True IGHV3 IGKV1 Kappa None None None None None 1kcs H L 0 P peptide ps1 peptide IMMUNE SYSTEM 11/11/01 CRYSTAL STRUCTURE OF ANTIBODY PC282 IN COMPLEX WITH PS1 PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Nair, D.T., Singh, K., Siddiqui, Z., Nayak, B.P., Rao, K.V.S., Salunke, D.M. 2.5 X-RAY DIFFRACTION 0.277 0.209 False False IGHV3 IGKV6 Kappa None None None None None 4pfe A NA 0 FLUORESCENT PROTEIN 04/29/14 Crystal structure of vsfGFP-0 AEQUOREA VICTORIA aequorea victoria, vicugna pacos Jauch, R., Chen, S.L. 2.603 X-RAY DIFFRACTION 0.255 0.199 False True IGHV1 None None None None None 6vn7 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 01/29/20 Cryo-EM structure of an activated VIP1 receptor-G protein complex HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Duan, J., Shen, D.-D., Zhou, X.E., Liu, Q.-F., Zhuang, Y.-W., Zhang, H.-B., Xu, P.-Y., Ma, S.-S., He, X.-H., Melcher, K., Zhang, Y., Xu, H.E., Yi, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6lhp H L 0 C | B protein | protein NA | NA vp3 protein | vp2 protein VIRUS 12/09/19 The cryo-EM structure of coxsackievirus A16 mature virion in complex with Fab 14B10 MUS MUSCULUS; COXSACKIEVIRUS A16 mus musculus mus musculus coxsackievirus a16 | coxsackievirus a16 He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W. 3.3 ELECTRON MICROSCOPY False False IGHV1 IGKV13 Kappa None None None None None 4okv A B 0 F protein anti-platelet aggregation protein BLOOD CLOTTING 01/23/14 Crystal structure of anopheline anti-platelet protein with Fab antibody ANOPHELES STEPHENSI; MUS MUSCULUS mus musculus mus musculus anopheles stephensi Park, S.Y., Sugiyama, K. 1.802 X-RAY DIFFRACTION 0.250 0.218 False False IGHV1 IGKV1 Kappa None None None None None 7we7 H L 0 D protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 1a2y B A 0 C protein lysozyme COMPLEX (IMMUNOGLOBULIN/HYDROLASE) 01/13/98 HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Tsuchiya, D., Mariuzza, R.A. 1.5 X-RAY DIFFRACTION 0.251 0.203 False True IGHV2 IGKV12 Kappa None None None None None 6mhg I T 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7te9 M N 0 B protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 class1 RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Furukawa, H. 3.92 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV19 Kappa None None None None None 6okq D C 0 IMMUNE SYSTEM 04/14/19 Crystal structure of the SF12 Fab HOMO SAPIENS homo sapiens homo sapiens Barnes, C.O., Bjorkman, P.J. 3.2 X-RAY DIFFRACTION 0.299 0.273 False True IGHV4 IGKV3 Kappa None None None None None 3bae H L 0 A peptide amyloid beta peptide IMMUNE SYSTEM 11/07/07 Crystal structure of Fab WO2 bound to the N terminal domain of Amyloid beta peptide (1-28) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Miles, L.A., Wun, K.S., Crespi, G.A., Parker, M.W. 1.593 X-RAY DIFFRACTION 0.250 0.207 False False IGHV8 IGKV1 Kappa None None None None None 4nkm A B 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.71 X-RAY DIFFRACTION 0.282 0.264 False True IGHV1 IGKV1 Kappa None None None None None 5xcq A B 0 C peptide c8 peptide IMMUNE SYSTEM 03/23/17 Crystal structure of P20.1 Fv-clasp fragment with its antigen peptide MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 1.313 X-RAY DIFFRACTION 0.182 0.165 False True IGHV9 IGLV1 Lambda None None None None None 1yzz B NA 0 UNKNOWN FUNCTION 03/01/05 Humanized caban33 at room temperature CAMELUS DROMEDARIUS camelus dromedarius Conrath, K., Vincke, C., Stijlemans, B., Schymkowitz, J., Decanniere, K., Muyldermans, S., Loris, R. 2.7 X-RAY DIFFRACTION 0.293 0.233 False True IGHV1 None None None None None 3hr5 H L 0 R peptide m1prime-derived peptide IMMUNE SYSTEM 06/08/09 M1prime peptide from IgE bound by humanized antibody 47H4 Fab MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Eigenbrot, C.W., Ultsch, M.H. 2.4 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 6i8h B NA 0 A protein protein eds1l IMMUNE SYSTEM 11/20/18 Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB15 ARABIDOPSIS THALIANA; LAMA GLAMA lama glama arabidopsis thaliana Niefind, K., Voss, M., Toelzer, C. 3.682 X-RAY DIFFRACTION 0.287 0.242 False True IGHV1 None None None None None 4xnz E F 0 D protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 01/16/15 Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 3.389 X-RAY DIFFRACTION 0.301 0.244 False True unknown unknown unknown None None None None None 4dgi H L 0 A protein major prion protein PROTEIN BINDING 01/26/12 Structure of POM1 FAB fragment complexed with human PrPc Fragment 120-230 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Baral, P.K., Wieland, B., Swayampakula, M., James, M.N. 2.4 X-RAY DIFFRACTION 0.289 0.258 False False IGHV1 IGKV5 Kappa 4.5e-07 -8.658567314824953 ITC TBD 6x5b H L 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN 05/25/20 Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6s8d Y U 0 E protein envelope glycoprotein VIRAL PROTEIN 07/09/19 Structure of ZEBOV GP in complex with 1T0227 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 3.49 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6fpv B NA 0 IMMUNE SYSTEM 02/12/18 A llama-derived JBP1-targeting nanobody LAMA GLAMA lama glama van Beusekom, B., Adamopoulos, A., Heidebrecht, T., Joosten, R.P., Perrakis, A. 1.64 X-RAY DIFFRACTION 0.195 0.163 False True IGHV1 None None None None None 7nd0 H L 0 A protein NA outer membrane protein assembly factor bama MEMBRANE PROTEIN 01/29/21 lateral-open conformation of the wild-type BAM complex (BamABCDE) bound to a bactericidal Fab fragment ESCHERICHIA COLI K-12; HOMO SAPIENS homo sapiens homo sapiens escherichia coli k-12 Iadanza, M.G., Haysom, S.H. 5.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV12 Kappa None None None None None 6i53 G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 TRANSPORT PROTEIN 11/12/18 Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Laverty, D., Desai, R., Uchanski, T., Masiulis, S., Wojciech, J.S., Malinauskas, T., Zivanov, J., Pardon, E., Steyaert, J., Miller, K.W., Aricescu, A.R. 3.2 ELECTRON MICROSCOPY False True IGHV1 None None None None None 4rau E D 0 F protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 7cwt P M 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike protein in complex with hb27 and fc05 Fab cocktail SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cui, Z., Wang, X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7zfa J K 0 C protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV4 IGKV1 Kappa None None None None None 6ct7 H L 0 S peptide ace-met-asp-val-phe-met-lys-gly-leu-ser-lys IMMUNE SYSTEM 12/19/18 Fab of anti-a-synuclein antibody BIIB054 in complex with acetylated a-synuclein peptide (1-10) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Arndt, J.W. 1.903 X-RAY DIFFRACTION 0.223 0.180 False True IGHV3 IGLV3 Lambda None None None None None 7mnn H L 0 A protein NA e3 sumo-protein ligase ranbp2 TRANSPORT PROTEIN/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T653I mutant in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 6.7 X-RAY DIFFRACTION 0.263 0.218 False True IGHV3 IGKV1 Kappa None None None None None 6dwi P O 0 NA NA NA NA IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 7vad H L 0 A protein NA sodium/bile acid cotransporter TRANSPORT PROTEIN 08/29/21 Cryo-EM structure of human NTCP complexed with YN69202Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Asami, J., Shimizu, T., Ohto, U. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7p40 I H 0 G protein NA spike glycoprotein VIRAL PROTEIN 07/09/21 P5C3 is a potent fab neutralizer SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 perez, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2g5b D C 0 J peptide bax peptide APOPTOSIS 02/22/06 Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Peyerl, F.W., Dai, S., Murphy, G.A., Marrack, P., Kappler, J.W. 2.3 X-RAY DIFFRACTION 0.275 0.234 False True IGHV7 IGKV8 Kappa None None None None None 5zxv H L 0 A protein mers-cov rbd VIRAL PROTEIN 05/21/18 Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Zhang, S., Wang, X. 4.482 X-RAY DIFFRACTION 0.343 0.307 False True IGHV3 IGLV1 Lambda 5.7600000000000006e-08 -9.87655083681725 SPR TBD 6h7m D NA 0 B protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; ESCHERICHIA COLI meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.76 X-RAY DIFFRACTION 0.285 0.265 False True IGHV1 None None None None None 2or9 I M 0 P peptide synthetic epitope peptide of 9e10 IMMUNE SYSTEM 02/02/07 The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Krauss, N., Scheerer, P., Hoehne, W. 2.7 X-RAY DIFFRACTION 0.310 0.252 False False IGHV5 IGKV3 Kappa 5.00e-07 -8.6 ITC 25 18473392 3jwd P O 0 B protein hiv-1 gp120 envelope glycoprotein VIRAL PROTEIN 09/18/09 Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Majeed, S., Ban, Y.A., Chen, L., Huang, C.C., Kong, L., Kwon, Y.D., Stuckey, J., Zhou, T., Robinson, J.E., Schief, W.R., Sodroski, J., Wyatt, R., Kwong, P.D. 2.61 X-RAY DIFFRACTION 0.275 0.201 False True IGHV1 IGKV1 Kappa None None None None None 6o42 H L 0 G peptide mper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/27/19 Crystal structure of the germline PGZL1 (PGZL1_gVmDmJ) Fab in complex with MPER peptide epitope. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.310 0.257 False True IGHV1 IGKV3 Kappa None None None None None 3cdf NA F 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 7c95 D C 0 NA NA NA NA IMMUNE SYSTEM 06/04/20 Crystal structure of the anti-human podoplanin antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Nakamura, S., Suzuki, K., Ogasawara, S., Naruchi, K., Shimabukuro, J., Tukahara, N., Kaneko, M.K., Kato, Y., Murata, T. 2.13 X-RAY DIFFRACTION 0.237 0.204 False False IGHV5 IGKV8 Kappa None None None None None 5uk4 c NA 0 C protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 7p5y H NA 0 B protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6uda K L 0 I protein ch505.n279k.g458y.sosip.664 gp120 VIRAL PROTEIN/Immune System 09/19/19 Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6q23 E F 0 C protein neuraminidase VIRAL PROTEIN,HYDROLASE/IMMUNE SYSTEM 08/06/19 Crystal structure of human 1G01 Fab in complex with influenza virus neuraminidase from A/California/04/2009 (H1N1) INFLUENZA A VIRUS (A/CALIFORNIA/04/2009 (H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009 (h1n1) Zhu, X., Wilson, I.A. 3.27 X-RAY DIFFRACTION 0.241 0.196 False True IGHV3 IGKV1 Kappa None None None None None 4uim C D 0 03/30/15 crystal structure of quinine-dependent Fab 314.3 MUS MUSCULUS mus musculus mus musculus Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.2596 0.2215 False False IGHV1 IGKV10 Kappa None None None None None 6ey6 M NA 0 E protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 6x87 A B 0 X protein NA circumsporozoite protein IMMUNE SYSTEM 06/01/20 CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Kucharska, I., Thai, E., Rubinstein, J., Julien, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7phq K NA 0 NA NA NA NA MEMBRANE PROTEIN 08/18/21 Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA lama glama Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 8.45 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3cmo H L 0 Immune System 03/24/08 HIV neutralizing monoclonal antibody YZ18 MUS MUSCULUS mus musculus mus musculus Jin, L., Prasad, V., Paul, S. 2.3 X-RAY DIFFRACTION 0.287 0.248 False False IGHV1 IGKV10 Kappa None None None None None 1nby B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 12/04/02 Crystal Structure of HyHEL-63 complexed with HEL mutant K96A MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Mariuzza, R.A., Li, Y., Urrutia, M., Smith-Gill, S.J. 1.8 X-RAY DIFFRACTION 0.250 0.216 False True IGHV3 IGKV5 Kappa 9.09e-05 SPR 25 12515535 3o2d H L 0 A protein t-cell surface glycoprotein cd4 IMMUNE SYSTEM 07/22/10 Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Freeman, M.M., Seaman, M.S., Rits-Volloch, S., Hong, X., Ho, D.D., Chen, B. 2.19 X-RAY DIFFRACTION 0.224 0.192 False True IGHV1 IGKV4 Kappa None None None None None 4r4n N O 0 M | a protein | peptide NA | NA m48u1 peptide | unknown VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | synthetic construct Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 7zxg E F 0 D protein NA gametocyte surface protein p45/48 CELL ADHESION 05/20/22 Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 4.2 X-RAY DIFFRACTION 0.276 0.259 False True IGHV5 IGKV8 Kappa None None None None None 5dq9 C D 0 C carbohydrate KD2 2-(acetylamino)-6-O-[2-(acetylamino)-2-deoxy-4-O-phosphono-beta-D-glucopyranosyl]-2-deoxy-1-O-phosphono-alpha-D-glucopyranose IMMUNE SYSTEM 09/14/15 Structure of S55-3 Fab in complex with Lipid A MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.245 0.212 False False IGHV5 IGKV3 Kappa None None None None None 4wv1 E D 0 F protein fibroblast growth factor receptor 2 TRANSFERASE/IMMUNE SYSTEM 11/04/14 Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, Y., Carter, P.J. 2.362 X-RAY DIFFRACTION 0.244 0.198 False True IGHV3 IGKV1 Kappa 2.6e-09 -11.712071867460315 SPR TBD 6d01 G H 0 J peptide nanp5 IMMUNE SYSTEM 04/09/18 Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Imkeller, K., Wardemann, H., Julien, J.P. 3.2 X-RAY DIFFRACTION 0.227 0.204 False True IGHV3 IGKV1 Kappa 2.86e-07 -8.927113962567878 Unknown TBD 6mg4 NA A 0 IMMUNE SYSTEM 04/10/19 Structure of full-length human lambda-6A light chain JTO HOMO SAPIENS homo sapiens Morgan, G.J., Yan, N.L., Mortenson, D.E., Stanfield, R.L., Wilson, I.A., Kelly, J.W. 1.75 X-RAY DIFFRACTION 0.221 0.171 False True IGLV6 Lambda None None None None None 5jr1 H L 0 IMMUNE SYSTEM 05/05/16 Crystal structure of 10E8 gHV-matureL antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.601 X-RAY DIFFRACTION 0.201 0.185 False True IGHV3 IGLV3 Lambda None None None None None 5gir H L 0 C peptide lys-pro-ile-ile-ile-gly-ser-his-ala-tyr-gly-asp IMMUNE SYSTEM 06/24/16 Crystal structure of a Fab fragment with its ligand peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Kitago, Y., Kaneko, K.K., Ogasawara, S., Kato, Y., Takagi, J. 1.93 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 IGKV5 Kappa None None None None None 5grj H L 0 A protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 08/11/16 Crystal structure of human PD-L1 with monoclonal antibody avelumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liu, K., Tan, S., Chai, Y., Chen, D., Song, H., Zhang, C.W.-H., Shi, Y., Liu, J., Tan, W., Lyu, J., Gao, S., Yan, J., Qi, J., Gao, G.F. 3.206 X-RAY DIFFRACTION 0.238 0.204 False True IGHV3 IGLV2 Lambda 4.21e-11 -14.15501182414434 SPR TBD 2fx8 I M 0 Q peptide fragment of hiv glycoprotein (gp41) IMMUNE SYSTEM 02/03/06 Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Brunel, F.M., Ferguson, S., Burton, D.R., Dawson, P.E., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.283 0.235 False True IGHV1 IGKV3 Kappa 3.02e-07 -8.89 SPR 17125793 7a4y B NA 0 E | D peptide | peptide NA | NA coiled-coil p5 peptide | coiled-coil p6 peptide DE NOVO PROTEIN 08/20/20 Crystal structure of the P5P6 coiled-coil in complex with nanobody Nb34. LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct | synthetic construct Hadzi, S. 2.157 X-RAY DIFFRACTION 0.229 0.196 False True IGHV3 NA NA None None None None None 7t5f C NA 0 A protein NA botulinum neurotoxin type b TOXIN 12/12/21 Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10 CLOSTRIDIUM BOTULINUM; CAMELIDAE camelidae clostridium botulinum Jin, R., Lam, K.-H. 2.6 X-RAY DIFFRACTION 0.222 0.194 False True IGHV1 NA NA None None None None None 6ks2 D C 0 NA NA NA NA IMMUNE SYSTEM 08/23/19 Structure of anti-Ghrelin receptor antibody MUS MUSCULUS mus musculus mus musculus Shiimura, Y., Horita, S., Asada, H., Hirata, K., Iwata, S., Kojima, M. 1.753 X-RAY DIFFRACTION 0.233 0.192 False True IGHV1 IGKV8 Kappa None None None None None 4yxh H L 0 A protein major prion protein IMMUNE SYSTEM 03/23/15 Crystal structure of Deer prion protein complexed with POM1 FAB MUS MUSCULUS; ODOCOILEUS HEMIONUS mus musculus mus musculus odocoileus hemionus Baral, P.K., Swayampakula, M., James, M.N.G. 2.7 X-RAY DIFFRACTION 0.288 0.243 False True IGHV1 IGKV5 Kappa None None None None None 7pqy B C 0 A protein NA spike protein s1 VIRAL PROTEIN 09/20/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FI-3A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 3.0 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa None None None None None 6apd F G 0 C protein fusion glycoprotein f0,envelope glycoprotein IMMUNE SYSTEM 08/17/17 Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 RESPIRATORY SYNCYTIAL VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus, humanimmunodeficiency virus 1 Wrapp, D., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.256 0.204 False True IGHV1 IGKV3 Kappa None None None None None 6ltg C D 0 IMMUNE SYSTEM 06/17/20 Crystal structure of the Fab fragment of murine monoclonal antibody OHV-3 against Human herpesvirus 6B MUS MUSCULUS mus musculus mus musculus Nishimura, M., Novita, B.D., Kato, T., Tjan, L.H., Wang, B., Wakata, A., Poetranto, A.L., Kawabata, A., Tang, H., Aoshi, T., Mori, Y. 1.63 X-RAY DIFFRACTION 0.204 0.182 False False IGHV2 IGKV3 Kappa None None None None None 4mhh G I 0 C protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/Viet Nam/1203/2004 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 3.564 X-RAY DIFFRACTION 0.238 0.201 False True IGHV1 IGKV3 Kappa 9.000000000000001e-10 -12.340621190735936 BLI TBD 7ljd N NA 0 A | B | G protein | protein | protein NA | NA | NA engineered gs protein alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 01/28/21 Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; LAMA GLAMA lama glama homo sapiens | rattus norvegicus | bos taurus Zhuang, Y., Krumm, B., Zhang, H., Zhou, X.E., Wang, Y., Guo, J., Huang, X.-P., Liu, Y., Wang, L., Cheng, X., Jiang, Y., Jiang, H., Melcher, K., Zhang, C., Yi, W., Roth, B.L., Zhang, Y., Xu, H.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1f3d H L 0 L Hapten TPM 2-(4-AMINOBENZYLAMINO)-3,4,5,6-TETRAHYDROPYRIDINIUM IMMUNE SYSTEM 06/02/00 CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN. MUS MUSCULUS mus musculus mus musculus mus musculus Golinelli-Pimpaneau, B., Goncalves, O., Dintinger, T., Blanchard, D., Knossow, M., Tellier, C. 1.87 X-RAY DIFFRACTION 0.218 0.198 False False IGHV1 IGKV1 Kappa None None None None None 5igx H L 0 G protein 426c.tm1deltav1-3 gp120 IMMUNE SYSTEM 02/28/16 Crystal structure of NIH45-46 Fab germline precursor in complex with 426c.TM1deltaV1-3 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Bjorkman, P.J. 3.39 X-RAY DIFFRACTION 0.286 0.280 False True IGHV1 IGKV3 Kappa 7.110000000000001e-07 -8.387550558127923 SPR TBD 7wq3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/22 Galanin-bound galanin receptor 1 in complex with Gi HOMO SAPIENS; RATTUS; BOS TAURUS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | rattus Duan, J., Shen, D.D., Xu, H.E., Zhang, Y., Jiang, Y. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2qtj A L 7 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6wzn A a 0 NA NA NA NA FLUORESCENT PROTEIN 05/14/20 Crystal Structure of a Fluorescent Single Chain Fv Chimera UNIDENTIFIED unidentified Close, D., Velappan, N., Hung, L.W., Naranjo, L., Hemez, C., DeVore, N., McCullough, D., Lillo, A.M., Waldo, G., Bradbury, A.R.M. 2.5 X-RAY DIFFRACTION 0.211 0.163 True True unknown unknown unknown None None None None None 1hh6 B A 0 C peptide pep-4 IMMUNE SYSTEM 12/21/00 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Hahn, M., Wessner, H., Schneider-Mergener, J., Hohne, W. 2.6 X-RAY DIFFRACTION 0.338 0.294 False False IGHV1 IGKV14 Kappa 1.00e-07 Other 4 10990450 6ck8 A NA 0 IMMUNE SYSTEM 02/27/18 Crystal structure of anti-influenza single-domain llama antibody SD38 LAMA GLAMA lama glama Zhu, X., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.211 0.177 False True IGHV1 None None None None None 4u05 B NA 0 NA NA NA NA IMMUNE SYSTEM 07/11/14 Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) S74A Variant LAMA GLAMA lama glama Legler, P.M. 2.5 X-RAY DIFFRACTION 0.239 0.209 False True IGHV1 NA NA None None None None None 1etz B A 0 B Hapten GAS ? IMMUNE SYSTEM 04/13/00 THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS MUS MUSCULUS mus musculus mus musculus mus musculus Guddat, L.W., Shan, L., Broomell, C., Ramsland, P.A., Fan, Z., Anchin, J.M., Linthicum, D.S., Edmundson, A.B. 2.6 X-RAY DIFFRACTION 0.294 0.198 False False IGHV8 IGLV1 Lambda 7.30e-08 -9.73 Other 8232332 5nlu A NA 0 IMMUNE SYSTEM 04/05/17 Structure of Nb36 crystal form 1 LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 1.193 X-RAY DIFFRACTION 0.198 0.175 False True IGHV1 None None None None None 2y07 H L 0 P peptide phage display derived antigen IMMUNE SYSTEM 11/30/10 CRYSTAL STRUCTURE ANALYSIS OF THE ANTI-(4-HYDROXY-3-NITROPHENYL) - ACETYL MURINE GERMLINE MONOCLONAL ANTIBODY BBE6.12H3 FAB FRAGMENT IN COMPLEX WITH A PHAGE DISPLAY DERIVED DODECAPEPTIDE PPYPAWHAPGNI MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.4 X-RAY DIFFRACTION 0.2572 0.2344 False False IGHV1 IGLV1 Lambda 6e-07 -8.488120381868695 Unknown TBD 7djx A NA 0 NA NA NA NA BIOSYNTHETIC PROTEIN 11/22/20 Clec4f Nanobody 246 LAMIUM MACULATUM lamium maculatum Wen, Y., Zheng, F. 1.98 X-RAY DIFFRACTION 0.216 0.200 False True IGHV1 NA NA None None None None None 7n8h M L 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/14/21 SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4at6 O P 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 5t3z H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/26/16 3.5 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gristick, H.B., Bjorkman, P.J. 3.5 X-RAY DIFFRACTION 0.298 0.275 False True IGHV4 unknown unknown None None None None None 4x7d D NA 0 A protein vp1 VIRAL PROTEIN 12/09/14 Crystal structure of 2012 NSW GII.4 P domain in complex with Nano-85 NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; LAMA GLAMA lama glama norovirus hu/gii.4/sydney/nsw0514/2012/au Koromyslova, A.D., Hansman, G.S. 2.15 X-RAY DIFFRACTION 0.238 0.196 False True IGHV1 3.5000000000000003e-09 -11.535955190950428 ITC TBD 7whj E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 1 complex structure of Omicron spike with Bn03 (1-up RBD, 3 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7zrc H L 0 C protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/04/22 OMI-38 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7kpg H L 0 S protein NA tyrosine-protein phosphatase non-receptor type substrate 1 SIGNALING PROTEIN 11/11/20 Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Sim, J., Pons, J. 2.27 X-RAY DIFFRACTION 0.282 0.234 False True IGHV3 IGLV3 Lambda None None None None None 4x0k A B 0 IMMUNE SYSTEM 11/21/14 Engineered Fab fragment specific for EYMPME (EE) peptide HOMO SAPIENS homo sapiens homo sapiens Johnson, J.L., Lieberman, R.L. 2.04 X-RAY DIFFRACTION 0.207 0.165 False True IGHV1 IGKV1 Kappa None None None None None 5mje B NA 0 A protein cytotoxic translational repressor of toxin-antitoxinstability system TOXIN 11/30/16 Crystal structure of the HigB2 toxin in complex with Nb8 VIBRIO CHOLERAE; LAMA GLAMA lama glama vibrio cholerae Hadzi, S., Loris, R. 2.599 X-RAY DIFFRACTION 0.297 0.227 False True IGHV1 None None None None None 1g7m B A 0 C protein lysozyme c HYDROLASE INHIBITOR/HYDROLASE 11/10/00 CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92V) MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Sundberg, E.J., Urrutia, M., Braden, B.C., Isern, J., Mariuzza, R.A. 1.9 X-RAY DIFFRACTION 0.226 0.194 False True IGHV2 IGKV12 Kappa None None None None None 7nll C NA 0 B protein NA surface glycoprotein VIRAL PROTEIN 02/22/21 SARS-CoV-2 Spike RBD (dimer) in complex with two Fu2 nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Das, H., Hallberg, B.M. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6wxl H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 05/11/20 Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer INFLUENZA A VIRUS (A/SHANGHAI/JS01/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/shanghai/js01/2013(h7n9)) | influenza a virus (a/shanghai/js01/2013(h7n9)) Gorman, J., Kwong, P.D. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 3uls B A 0 IMMUNE SYSTEM 11/11/11 Crystal structure of Fab12 HOMO SAPIENS homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 2.495 X-RAY DIFFRACTION 0.267 0.212 False True IGHV6 IGLV3 Lambda None None None None None 5wk3 W V 0 D protein c-c motif chemokine 17 IMMUNE SYSTEM 07/24/17 CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.231 0.180 False True IGHV5 IGKV4 Kappa None None None None None 1d5b B A 0 IMMUNE SYSTEM 10/06/99 UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C. 2.8 X-RAY DIFFRACTION 0.285 0.232 False True IGHV1 IGKV14 Kappa None None None None None 7vdm S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/07/21 Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yu, L., Fang, Y. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7nx9 A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the N501Y mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.4 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGKV3 Kappa None None None None None 2pcp B A 0 B Hapten 1PC 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE IMMUNOGLOBULIN 06/02/98 ANTIBODY FAB COMPLEXED WITH PHENCYCLIDINE MUS MUSCULUS mus musculus mus musculus mus musculus Lim, K., Owens, S.M., Arnold, L., Sacchettini, J.C., Linthicum, D.S. 2.2 X-RAY DIFFRACTION 0.290 0.196 False False IGHV1 IGKV1 Kappa 2e-09 -11.867518412372508 Unknown TBD 4tuo C D 0 D carbohydrate GAL polysaccharide IMMUNE SYSTEM 06/24/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Golik, P., Grudnik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G. 1.55 X-RAY DIFFRACTION 0.206 0.166 False True IGHV1 IGKV1 Kappa None None None None None 7eh5 F Q 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/28/21 Cryo-EM structure of SARS-CoV-2 S-D614G variant in complex with neutralizing antibodies, RBD-chAb15 and RBD-chAb45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Chang, Y.C., Wu, H.C., Hsu, S.T.D. 4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV5 Kappa None None None None None 2imm NA A 0 IMMUNOGLOBULIN 03/01/93 REFINED CRYSTAL STRUCTURE OF A RECOMBINANT IMMUNOGLOBULIN DOMAIN AND A COMPLEMENTARITY-DETERMINING REGION 1-GRAFTED MUTANT MUS MUSCULUS mus musculus Steipe, B., Huber, R. 2.0 X-RAY DIFFRACTION unknown 0.149 False True unknown unknown unknown None None None None None 2oqj H G 0 I peptide peptide 2g12.1 (acppshvldmrsgtclaaegk) Immune system 01/31/07 Crystal structure analysis of Fab 2G12 in complex with peptide 2G12.1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Menendez, A., Scott, J.K., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.275 0.234 False False IGHV3 IGKV1 Kappa 2.00e-04 -5.04 SPR 25 18198210 2yk1 H L 0 H Hapten NCT (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE IMMUNE SYSTEM 05/25/11 Structure of human anti-nicotine Fab fragment in complex with nicotine HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tars, K., Kotelovica, S., Lipowsky, G., Bauer, M., Beerli, R., Bachmann, M., Maurer, P. 1.85 X-RAY DIFFRACTION 0.26434 0.22446 False True IGHV4 IGLV1 Lambda 7.40e-09 -11.09 Other 22079050 7wgd H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 12/28/21 X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in substrate-free form. Drosophila melanogaster; Mus musculus mus musculus mus musculus drosophila melanogaster Joseph, D., Penmatsa, A. 3.2 X-RAY DIFFRACTION 0.286 0.244 False True IGHV5 IGKV4 Kappa None None None None None 5x8l G L 0 B protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 03/03/17 PD-L1 in complex with atezolizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, H.T. 3.1 X-RAY DIFFRACTION 0.256 0.208 False True IGHV3 IGKV1 Kappa None None None None None 4fqq H L 0 IMMUNE SYSTEM 06/25/12 Crystal Structure of Germline Antibody PGT121-GL Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 2.42 X-RAY DIFFRACTION 0.237 0.194 False True IGHV4 IGLV3 Lambda None None None None None 4dgv H L 0 A peptide e2 peptide IMMUNE SYSTEM/VIRAL PROTEIN 01/26/12 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody HCV1, P2(1) form HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Kong, L., Wilson, I.A., Law, M. 1.805 X-RAY DIFFRACTION 0.214 0.170 False True IGHV3 IGKV3 Kappa None None None None None 7t0j D C 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.15 X-RAY DIFFRACTION 0.281 0.230 False True IGHV7 IGKV8 Kappa None None None None None 7amp H L 0 B protein NA beta chain 1 of a6 t-cell receptor trbc1 IMMUNE SYSTEM 10/09/20 Crystal structure of the complex of HuJovi-1 Fab with the human A6 T-cell receptor TRBC1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferrari, M., Bulek, A., Bughda, R., Jha, R., Welin, M., Logan, D.T., Sewell, A., Onuoha, S., Pule, M. 2.64 X-RAY DIFFRACTION 0.289 0.237 False True IGHV1 IGKV1 Kappa None None None None None 7l5b H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 12/21/20 Crystallographic structure of neutralizing antibody 2-15 in complex with SARS-CoV-2 spike receptor-binding Domain (RBD). SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.18 X-RAY DIFFRACTION 0.239 0.187 False True IGHV1 IGLV2 Lambda None None None None None 7tfo H L 0 A protein NA envelope glycoprotein bg505 sosip.664 - gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/06/22 Cryo-EM structure of HIV-1 Env trimer BG505 SOSIP.664 in complex with CD4bs antibody Ab1573 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 1ndm B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 12/09/02 Crystal structure of Fab fragment of antibody HyHEL-26 complexed with lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Mariuzza, R.A., Li, Y., Li, H. 2.1 X-RAY DIFFRACTION 0.258 0.208 False True IGHV3 IGKV5 Kappa None None None None None 6b08 C B 0 A protein pfs25 IMMUNE SYSTEM 09/14/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1276 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum Scally, S.W., McLeod, B., Bosch, A., King, C.R., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.233 0.191 False True IGHV1 IGLV3 Lambda 1.6e-08 -10.635483235413165 BLI TBD 7u2l E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/24/22 C5guano-uOR-Gi-scFv16 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Wang, H., Qu, Q., Skiniotis, G., Kobilka, B. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6kx0 A B 0 NA NA NA NA IMMUNE SYSTEM 09/09/19 Crystal structure of SN-101 mAb non-liganded form MUS MUSCULUS mus musculus mus musculus Wakui, H., Tanaka, Y., Kato, K., Ose, T., Matsumoto, I., Min, Y., Tachibana, T., Nishimura, S.-I. 2.404 X-RAY DIFFRACTION 0.278 0.225 False True IGHV6 IGKV1 Kappa None None None None None 6xc4 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.3 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 2.341 X-RAY DIFFRACTION 0.219 0.184 False True IGHV3 IGKV3 Kappa None None None None None 6anp H L 0 IMMUNE SYSTEM 08/14/17 CAT192 Fab Insertion Mutant H5/L0 HOMO SAPIENS homo sapiens homo sapiens Lord, D.M., Wei, R.R. 2.45 X-RAY DIFFRACTION 0.235 0.183 False True IGHV3 IGKV1 Kappa None None None None None 3u30 F E 0 D protein linear di-ubiquitin IMMUNE SYSTEM 10/04/11 Crystal structure of a linear-specific Ubiquitin fab bound to linear ubiquitin HOMO SAPIENS homo sapiens homo sapiens homo sapiens Matsumoto, M.L., Dong, K.C., Yu, C., Phu,L, Gao, X., Hannoush, R.N., Hymowitz, S.G., Kirkpatrick, D.S., Dixit, V.M., Kelley, R.F. 2.428 X-RAY DIFFRACTION 0.258 0.229 False True IGHV3 IGKV1 Kappa None None None None None 7t5f E NA 0 D protein NA botulinum neurotoxin type b TOXIN 12/12/21 Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10 CLOSTRIDIUM BOTULINUM; CAMELIDAE camelidae clostridium botulinum Jin, R., Lam, K.-H. 2.6 X-RAY DIFFRACTION 0.222 0.194 False True IGHV3 NA NA None None None None None 6dcq H L 0 B | A protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN 05/08/18 Ectodomain of full length, wild type HIV-1 glycoprotein clone PC64M18C043 in complex with PGT151 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Rantalainen, K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7n0u H L 0 C protein NA recombinant bet v 1 ALLERGEN 05/26/21 Complex of recombinant Bet v 1 with Fab fragment of REGN5713 MUS MUSCULUS; BETULA PENDULA mus musculus mus musculus betula pendula Franklin, M.C., Romero Hernandez, A. 3.0 X-RAY DIFFRACTION 0.280 0.240 False True IGHV4 IGKV3 Kappa None None None None None 7faf g f 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 S protein of SARS-CoV-2 in complex bound with P36-5D2 (state1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, L., Wang, X., Zhang, S., Shan, S. 3.69 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 1ek3 NA B 0 IMMUNE SYSTEM 03/06/00 KAPPA-4 IMMUNOGLOBULIN VL, REC HOMO SAPIENS homo sapiens Pokkuluri, P.R., Huang, D.-B., Raffen, R., Stevens, F.J., Schiffer, M. 1.9 X-RAY DIFFRACTION 0.237 0.187 False True IGKV4 Kappa None None None None None 1ncd H L 0 N protein influenza a subtype n9 neuraminidase HYDROLASE(O-GLYCOSYL) 01/21/92 REFINED CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS N9 NEURAMINIDASE-NC41 FAB COMPLEX INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Tulip, W.R., Varghese, J.N., Colman, P.M. 2.9 X-RAY DIFFRACTION unknown 0.157 False False IGHV9 IGKV6 Kappa None None None None None 7rt9 C D 0 Z peptide NA peptide yy HORMONE/IMMUNE SYSTEM 08/12/21 Crystal structures of human PYY and NPY HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.213 0.179 False True IGHV3 IGKV1 Kappa None None None None None 3etb H h 0 L protein anthrax protective antigen IMMUNE SYSTEM/TOXIN 10/07/08 Crystal structure of the engineered neutralizing antibody M18 complexed with anthrax protective antigen domain 4 MUS MUSCULUS; BACILLUS ANTHRACIS mus musculus bacillus anthracis Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D. 3.8 X-RAY DIFFRACTION 0.276 0.232 True True unknown unknown unknown 3.50e-11 -14.26 SPR 25 19361425 3j3o H L 0 1 protein protein vp1 VIRUS/IMMUNE SYSTEM 04/10/13 Conformational Shift of a Major Poliovirus Antigen Confirmed by Immuno-Cryogenic Electron Microscopy: 160S Poliovirus and C3-Fab Complex MUS MUSCULUS; UNIDENTIFIED; HUMAN POLIOVIRUS 1 mus musculus mus musculus human poliovirus 1 Lin, J., Cheng, N., Hogle, J.M., Steven, A.C., Belnap, D.M. 11.1 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 4qhk K L 0 IMMUNE SYSTEM 05/28/14 UCA (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.487 X-RAY DIFFRACTION 0.285 0.269 False True IGHV4 IGLV3 Lambda None None None None None 6fy1 H L 0 G protein cap228 autologous scaffolded v1v2 IMMUNE SYSTEM 03/10/18 Crystal structure of a V2p-reactive RV144 vaccine-like antibody, CAP228-16H, in complex with a scaffolded autologous V1V2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Moore, P.L., Morris, L. 3.132 X-RAY DIFFRACTION 0.271 0.221 False True IGHV5 IGLV3 Lambda None None None None None 7tyh N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/13/22 Human Amylin2 Receptor in complex with Gs and human calcitonin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1g9m H L 0 G protein envelope glycoprotein gp120 Viral protein/Immune system 11/24/00 HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwong, P.D., Wyatt, R., Majeed, S., Robinson, J., Sweet, R.W., Sodroski, J., Hendrickson, W.A. 2.2 X-RAY DIFFRACTION 0.330 0.268 False True IGHV1 IGKV3 Kappa None None None None None 6xxv A B 0 C protein s2_1.2 IMMUNE SYSTEM 01/28/20 Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yang, C., Sesterhenn, F., Correia, B.E., Pojer, F. 2.20116 X-RAY DIFFRACTION 0.244 0.209 False True IGHV3 IGKV1 Kappa None None None None None 6z7w F E 0 M | N peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Human insulin in complex with the analytical antibody HUI-018 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.42 X-RAY DIFFRACTION 0.275 0.209 False True IGHV1 IGKV6 Kappa None None None None None 7s2s C NA 0 B protein NA interleukin-2 receptor subunit beta PROTEIN BINDING 09/03/21 nanobody bound to Interleukin-2Rbeta CAMELUS BACTRIANUS; HOMO SAPIENS camelus bactrianus homo sapiens Glassman, C.R., Jude, K.M., Yen, M., Garcia, K.C. 1.93 X-RAY DIFFRACTION 0.247 0.213 False True IGHV1 NA NA None None None None None 6txz J N 0 C protein hepatitis a virus cellular receptor 2 IMMUNE SYSTEM 04/08/20 FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Musil, D., Sood, V. 3.06 X-RAY DIFFRACTION 0.253 0.197 False True IGHV3 IGLV2 Lambda None None None None None 2kh2 B b 0 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7ew5 B C 0 M protein NA major capsid protein l1 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 3pnw K J 0 L protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 7k37 J I 0 C | D protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 7.8 INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Xiang, Y., Gao, J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 1qyg H L 0 H Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 09/10/03 ANTI-COCAINE ANTIBODY M82G2 COMPLEXED WITH BENZOYLECGONINE MUS MUSCULUS mus musculus mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Petsko, G., Ringe, D. 1.81 X-RAY DIFFRACTION 0.216 0.178 False False IGHV6 IGKV2 Kappa 1.4e-07 -9.350354316900614 Unknown TBD 7bua H L 0 A protein genome polyprotein VIRUS 05/13/20 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6ule A B 0 I peptide circumsporozoite protein IMMUNE SYSTEM 06/10/20 Crystal structure of 2541 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Thai, E., Scally, S.W., Murugan, R., Wardemann, H., Julien, J.P. 2.55 X-RAY DIFFRACTION 0.259 0.209 False True IGHV3 IGKV1 Kappa None None None None None 6xv8 C NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/21/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_G10 LAMA GLAMA; HELICOBACTER PYLORI (STRAIN G27) lama glama, helicobacter pylori (strain g27) Steyaert, J., Uchanski, T., Fischer, B. 3.15 X-RAY DIFFRACTION 0.297 0.255 False True IGHV1 NA NA None None None None None 6u55 A NA 0 B protein nucleoprotein IMMUNE SYSTEM 08/26/19 Anti-Zaire ebolavirus Nucleoprotein Single Domain Antibody Zaire E (ZE) Complexed with Sudan ebolavirus Nucleoprotein C-terminal Domain 634-738 LAMA GLAMA; SUDAN EBOLAVIRUS (STRAIN BONIFACE-76) lama glama sudan ebolavirus (strain boniface-76) Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 1.93 X-RAY DIFFRACTION 0.263 0.193 False True IGHV1 None None None None None 4rzc E F 0 E carbohydrate M6P ALPHA-D-MANNOSE-6-PHOSPHATE IMMUNE SYSTEM 12/19/14 Fv M6P-1 in complex with mannose-6-phosphate ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Blackler, R.J., Evans, D.W., Evans, S.V., Muller-Loennies, S. 2.723 X-RAY DIFFRACTION 0.267 0.226 False True IGHV1 IGKV1 Kappa None None None None None 4nkm E F 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.71 X-RAY DIFFRACTION 0.282 0.264 False True IGHV1 IGKV1 Kappa None None None None None 6xq2 F E 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S8V2-37 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2) INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 3.002 X-RAY DIFFRACTION 0.290 0.247 False True IGHV3 IGKV1 Kappa None None None None None 3jba H L 0 A protein major capsid protein l1 VIRUS/IMMUNE SYSTEM 08/11/15 The U4 antibody epitope on human papillomavirus 16 identified by cryo-EM HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 Guan, J., Bywaters, S.M., Brendle, S.A., Lee, H., Ashley, R.E., Christensen, N.D., Hafenstein, S. 12 ELECTRON MICROSCOPY False False IGHV5 IGKV8 Kappa None None None None None 7a4y C NA 0 NA NA NA NA DE NOVO PROTEIN 08/20/20 Crystal structure of the P5P6 coiled-coil in complex with nanobody Nb34. LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama Hadzi, S. 2.157 X-RAY DIFFRACTION 0.229 0.196 False True IGHV3 NA NA None None None None None 7orb C D 0 X protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the L452R mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-75 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.5 X-RAY DIFFRACTION 0.251 0.213 False True IGHV1 IGKV3 Kappa None None None None None 6x04 L NA 0 K protein NA nucleoporin nup133 STRUCTURAL PROTEIN 05/15/20 Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN5 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 2.68 X-RAY DIFFRACTION 0.261 0.244 False True IGHV1 NA NA None None None None None 5jo4 C D 0 IMMUNE SYSTEM 05/01/16 Antibody Fab Fragment Complex HOMO SAPIENS homo sapiens homo sapiens Zhang, Z., Prachanronarong, K.P., Marasco, W.A., Schiffer, C.A.S. 2.53 X-RAY DIFFRACTION 0.248 0.197 False True IGHV1 IGKV1 Kappa None None None None None 6vy2 H L 0 A protein glycoprotein 120 IMMUNE SYSTEM 02/25/20 Cryo-EM structure of M1214_N1 Fab in complex with CH505 TF chimeric SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 4.86 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 4hij D C 0 D carbohydrate RAM polysaccharide IMMUNE SYSTEM 10/11/12 Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound L-rhamnose-(1-2)-alpha-D-galactose-(3-O)-phosphate-2-glycerol HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Schrader, J.W., Pai, E.F. 2.1 X-RAY DIFFRACTION 0.262 0.249 False True IGHV3 IGKV3 Kappa None None None None None 7ll1 J K 0 G protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/03/21 Cryo-EM structure of BG505 DS-SOSIP in complex with glycan276-dependent broadly neutralizing antibody VRC40.01 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.73 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7pg8 U S 0 W protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 6xrj A B 0 NA NA NA NA IMMUNE SYSTEM 07/13/20 Crystal structure of the disulfide linked DH717.1 Fab dimer, derived from a macaque HIV-1 vaccine-induced Env glycan-reactive neutralizing antibody B cell lineage HOMO SAPIENS homo sapiens homo sapiens Manne, K., Nicely, N.I., Acharya, P. 3.15 X-RAY DIFFRACTION 0.282 0.245 False True IGHV4 IGLV2 Lambda None None None None None 3j8z I M 0 B | A protein | protein NA | NA l1 | l1 VIRUS/IMMUNE SYSTEM 11/20/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 | human papillomavirus type 16 Guan, J., Hafenstein, S. 14 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 6azx A B 0 IMMUNE SYSTEM 09/13/17 Crystal structure of the neutralizing anti-circumsporozoite protein 663 antibody HOMO SAPIENS homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.238 0.206 False True IGHV3 IGKV2 Kappa None None None None None 5yd5 C c 0 D peptide peptide epitope (mutation n3a) IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide (mutation N3A) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.96 X-RAY DIFFRACTION 0.258 0.203 True True unknown unknown unknown None None None None None 7l2f H L 0 A protein NA spike glycoprotein Viral Protein/IMMUNE SYSTEM 12/16/20 Cryo-EM structure of NTD-directed neutralizing antibody 5-24 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7mfu B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 04/11/21 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 1.7 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 NA NA None None None None None 3kdm H L 0 H Hapten TES TESTOSTERONE IMMUNE SYSTEM 10/23/09 Crystal Structure of Human Anti-steroid Fab 5F2 in Complex with Testosterone HOMO SAPIENS homo sapiens homo sapiens homo sapiens Niemi, M.H., Rouvinen, J. 1.5 X-RAY DIFFRACTION 0.208 0.180 True True IGHV3 IGKV1 Kappa 1.00e-07 -9.54 Other 25 21360611 4nhh O Q 0 C protein 2g12 igg dimer heavy chain IMMUNE SYSTEM 11/05/13 Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 6.5 X-RAY DIFFRACTION 0.366 0.381 False True unknown IGKV1 Kappa None None None None None 7vla S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/02/21 Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Shao, Z., Shen, Q., Mao, C., Yao, B., Chen, L., Zhang, H., Shen, D., Zhang, C., Li, W., Du, X., Li, F., Ma, H., Chen, Z., Xu, H.E., Ying, S., Zhang, Y., Shen, H. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1za3 H L 0 R protein tumor necrosis factor receptor superfamily member 10b IMMUNE SYSTEM/SIGNALING PROTEIN 04/05/05 The crystal structure of the YSd1 Fab bound to DR5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Fellouse, F.A., Li, B., Compaan, D.M., Peden, A.A., Hymowitz, S.G., Sidhu, S.S. 3.35 X-RAY DIFFRACTION 0.280 0.224 False True IGHV3 IGKV1 Kappa 3.40e-08 -10.18 SPR 15854651 6pyc NA L 0 L Hapten P4S (3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide IMMUNE SYSTEM 07/29/19 Structure of kappa-on-heavy (KoH) antibody Fab bound to the cardiac hormone marinobufagenin MUS MUSCULUS mus musculus mus musculus Franklin, M.C., Macdonald, L.E., McWhirter, J., Murphy, A.J. 3.6 X-RAY DIFFRACTION 0.287 0.234 False True IGKV3 Kappa None None None None None 7tpr E NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/22 Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Butay, K.J., Zhu, J., Dandey, V.P., Hong, J., Kwon, H.J., Chen, C.Z., Duan, Z., Li, D., Ren, H., Liang, T., Martin, N., Esposito, D., Ortega-Rodriguez, U., Xu, M., Xie, H., Ho, M., Cachau, R., Borgnia, M.J. 2.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6mw9 O P 0 N protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-3 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 5n09 I M 0 B protein envelope glycoprotein e Immune System/Viral Protein 02/02/17 Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Duquerroy, S., Rouvinski, A., Guardado-Calvo, P., Vaney, M.-C., Sharma, A., Rey, F. 3.9 X-RAY DIFFRACTION 0.347 0.304 False True IGHV3 IGLV2 Lambda None None None None None 4ris H L 0 P peptide envelope glycoprotein Immune system 10/07/14 Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H.-X., Alam, S.M., Hwang, K.-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F. 2.3 X-RAY DIFFRACTION 0.246 0.161 False True IGHV5 IGLV6 Lambda 9e-07 -8.247888922505172 Unknown TBD 5nml E NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 4ut9 H L 0 A protein envelope glycoprotein e VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein dimer in complex with the ScFv fragment of the broadly neutralizing human antibody EDE1 C10 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 3.2 X-RAY DIFFRACTION 0.2487 0.1975 False True IGHV1 IGLV2 Lambda None None None None None 4fqc H L 0 IMMUNE SYSTEM 06/25/12 Crystal Structure of PGT121 Fab Bound to a complex-type sialylated N-glycan HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 2.4 X-RAY DIFFRACTION 0.249 0.201 False True IGHV4 IGLV3 Lambda None None None None None 6wiy H L 0 NA NA NA NA IMMUNE SYSTEM 04/11/20 Crystal structure of Fab 54-1G05 HOMO SAPIENS homo sapiens homo sapiens Wu, N.C., Wilson, I.A. 1.65 X-RAY DIFFRACTION 0.188 0.158 False True IGHV6 IGKV3 Kappa None None None None None 6mlm E I 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 09/27/18 H7 HA0 in complex with Fv from H7.5 IgG INFLUENZA A VIRUS (A/NEW YORK/107/2003(H7N2)); INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/new york/107/2003(h7n2)) Pallesen, J., Turner, H.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5mhg H L 0 H Hapten 4IB TETRAIODOBISPHENOLA IMMUNE SYSTEM 11/24/16 Crystal structure of anti-T4 Fab fragment with tetraiodoBPA MUS MUSCULUS mus musculus mus musculus mus musculus Parkkinen, T., Rouvinen, J. 2.801 X-RAY DIFFRACTION 0.291 0.221 False True IGHV5 IGKV4 Kappa None None None None None 7pi2 H I 0 G protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to monoclonal antibody Cy.003 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 3.14 X-RAY DIFFRACTION 0.239 0.219 False True unknown unknown unknown None None None None None 4o9h H L 0 A protein interleukin-6 IMMUNE SYSTEM 01/02/14 Structure of Interleukin-6 in complex with a Camelid Fab fragment HOMO SAPIENS; LLAMA GLAMA lama glama lama glama homo sapiens Klarenbeek, A., Blanchetot, C., Schragel, G., Sadi, A.S., Ongenae, N., Hemrika, W., Wijdenes, J., Spinelli, S., Desmyter, A., Cambillau, C., Hultberg, A., Kretz-rommel, A., Dreier, T., De haard, H.J.W., Roovers, R.C. 2.42 X-RAY DIFFRACTION 0.244 0.216 False True IGHV3 IGLV8 Lambda None None None None None 2kqn NA B 3 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7wkx A C 0 F protein NA interleukin-17a CYTOKINE 01/12/22 IL-17A in complex with the humanized antibody HB0017 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xu, J., Zhu, X., He, Y. 2.81 X-RAY DIFFRACTION 0.254 0.206 False True IGHV7 IGKV2 Kappa None None None None None 6o2a C D 0 G | N peptide | protein NA | NA circumsporozoite protein | anti-kappa vhh domain IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein NDN and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | lama glama Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.15 X-RAY DIFFRACTION 0.221 0.193 False True IGHV3 IGKV3 Kappa None None None None None 5y2m I J 0 D | A | C protein | protein | protein NA | NA | NA hemagglutinin | hemagglutinin | hemagglutinin IMMUNE SYSTEM 07/26/17 Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the H4N6 duck isolate (H4-CZ/56) hemagglutinin INFLUENZA A VIRUS (STRAIN A/DUCK/CZECHOSLOVAKIA/1956 H4N6); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (straina/duck/czechoslovakia/1956 h4n6) | influenza a virus (straina/duck/czechoslovakia/1956 h4n6) | influenza a virus (straina/duck/czechoslovakia/1956 h4n6) Xiao, H., Qi, J., Gao, F.G. 3.8 X-RAY DIFFRACTION 0.277 0.236 False True IGHV3 IGKV3 Kappa None None None None None 6bft A B 0 G protein vascular endothelial growth factor a IMMUNE SYSTEM 10/27/17 Structure of Bevacizumab Fab mutant in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Christie, M., Christ, D. 2.55 X-RAY DIFFRACTION 0.220 0.170 False True IGHV3 IGKV1 Kappa None None None None None 7kbt E F 0 A protein NA coagulation factor viii,coagulation factor viii,coagulationfactor viii,coagulation factor viii,coagulation factor viii BLOOD CLOTTING/Immune System 10/02/20 Factor VIII in complex with the anti-C2 domain antibody, G99 SUS SCROFA; HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus sus scrofa, homo sapiens Ronayne, E.K., Gish, J., Wilson, C., Peters, S., Spencer, H.T., Spiegel, P.C., Childers, K.C. 4.15 X-RAY DIFFRACTION 0.338 0.300 False True IGHV1 IGKV9 Kappa None None None None None 4xcn G I 0 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA); 2.9 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.246 0.193 False True IGHV1 IGKV3 Kappa None None None None None 3i2c H L 0 IMMUNE SYSTEM 06/29/09 Crystal structure of anti-IL-23 antibody CNTO4088 MUS MUSCULUS mus musculus mus musculus Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.8 X-RAY DIFFRACTION 0.235 0.196 False True IGHV10 IGKV3 Kappa None None None None None 5ujz G g 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 1 HOMO SAPIENS; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6mui G H 0 F protein NA e2 VIRUS/IMMUNE SYSTEM 10/23/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-42 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.7 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 1fe8 H L 0 A protein von willebrand factor IMMUNE SYSTEM 07/21/00 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Bouma, B., Huizinga, E.G., Schiphorst, M.E., Sixma, J.J., Kroon, J., Gros, P. 2.03 X-RAY DIFFRACTION 0.264 0.227 False False IGHV2 IGKV10 Kappa 2e-06 -7.7747861441417445 Unknown TBD 5mp1 C D 0 B peptide microtubule-associated protein tau IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 3.1 X-RAY DIFFRACTION 0.268 0.222 False False IGHV1 IGKV8 Kappa None None None None None 6urm D E 0 C protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 10/23/19 Crystal structure of vaccine-elicited receptor-binding site targeting antibody LPAF-a.01 in complex with Hemagglutinin H1 A/California/04/2009 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhou, T., Cheung, S.F., Kwong, P.D. 2.65 X-RAY DIFFRACTION 0.262 0.215 False True IGHV2 IGLV3 Lambda None None None None None 7s4s H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 09/09/21 Crystal Structure of SARS-CoV-2 S receptor-binding domain (RBD) in complex CoV11 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tolbert, W.D., Pazgier, M. 2.05 X-RAY DIFFRACTION 0.198 0.166 False True IGHV3 IGKV3 Kappa None None None None None 5gz0 D C 0 IMMUNE SYSTEM 09/26/16 Crystal structure of FM329, a recombinant Fab adopted from cetuximab HOMO SAPIENS/MUS MUSCULUS XENOGRAFT homo sapiens/mus musculus xenograft homo sapiens/mus musculus xenograft Sim, D.W., Kim, J.H., Kim, Y.P., Won, H.S. 1.7 X-RAY DIFFRACTION 0.227 0.188 False True IGHV2 IGKV5 Kappa None None None None None 3d0v B A 0 C peptide gp41 peptide lleldkwaslw IMMUNE SYSTEM 05/02/08 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LLELDKWASLW HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bryson, S., Julien, J.P., Pai, E.F. 2.05 X-RAY DIFFRACTION 0.232 0.218 False False IGHV2 IGKV1 Kappa None None None None None 3ztj I J 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/VIRAL PROTEIN 07/08/11 Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin. HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Voss, J.E., Vachieri, S.G., Gamblin, S.J., Collins, P.J., Haire, L.F., Skehel, J.J. 3.41 X-RAY DIFFRACTION 0.28434 0.23410 False True IGHV3 IGKV4 Kappa None None None None None 1opg H L 0 IMMUNOGLOBULIN 04/28/95 OPG2 FAB FRAGMENT HOMO SAPIENS homo sapiens homo sapiens Kodandapani, R., Veerapandian, B., Ely, K.R. 2.0 X-RAY DIFFRACTION unknown unknown False False IGHV5 IGKV5 Kappa None None None None None 4jg0 H L 0 P peptide phosphopeptide immune system 02/28/13 Structure of phosphoserine/threonine (pSTAb) scaffold bound to pSer peptide ESCHERICHIA COLI; SYNTHETIC CONSTRUCT Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 1.81 X-RAY DIFFRACTION 0.202 0.161 False True IGHV3 IGKV3 Kappa 1.72e-07 -9.228390334290179 Unknown TBD 3j2z F E 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m10 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 7q9m E F 0 B protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-53 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 6mnf M K 0 M carbohydrate BMA polysaccharide IMMUNE SYSTEM 10/01/18 Anti-HIV-1 Fab 2G12 + Man8 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 2.758 X-RAY DIFFRACTION 0.252 0.218 False True unknown IGKV1 Kappa 1.3e-06 -8.030017991549332 Unknown TBD 5vxl B NA 0 A protein invasin ipad IMMUNE SYSTEM 05/23/17 2.80 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JPS-G3 SHIGELLA FLEXNERI; VICUGNA PACOS vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.8 X-RAY DIFFRACTION 0.273 0.202 False True IGHV1 None None None None None 1ggi J M 0 Q peptide hiv-1 v3 loop peptide antigen IMMUNOGLOBULIN 04/02/93 CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN MUS MUSCULUS mus musculus Stanfield, R.L., Rini, J.M., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.188 False True IGHV8 IGKV3 Kappa None None None None None 6ml8 H L 0 A protein hemagglutinin VIRAL PROTEIN 09/27/18 Crystal structure of hemagglutinin from H1N1 Influenza A virus A/Denver/57 bound to the C05 antibody INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/DENVER/1957(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.92 X-RAY DIFFRACTION 0.264 0.201 False True IGHV3 IGKV1 Kappa None None None None None 1mck NA A 0 P peptide peptide n-acetyl-d-glu-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 7ly3 F E 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 Crystal structure of SARS-CoV-2 S NTD bound to S2M28 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.0 X-RAY DIFFRACTION 0.234 0.209 False True IGHV3 IGLV3 Lambda None None None None None 6bli A B 0 C peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/10/17 RSV G peptide bound to Fab CB002.5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human respiratory syncytial virus a (strainrsb6256) Jones, H.G., McLellan, J.S., Langedijk, J.P. 2.12 X-RAY DIFFRACTION 0.218 0.169 False True IGHV4 IGKV1 Kappa 5.200000000000001e-10 -12.665637564550789 Unknown TBD 4u6v K M 0 B protein alpha-hemolysin IMMUNE SYSTEM 07/29/14 Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS TCH60 homo sapiens homo sapiens staphylococcus aureus subsp. aureus tch60 Oganesyan, V.Y., Peng, L., Damschroder, M.M., Cheng, L., Sadowska, A., Tkaczyk, C., Sellman, B., Wu, H., Dall'Acqua, W.F. 2.56 X-RAY DIFFRACTION 0.235 0.198 False True IGHV3 IGKV1 Kappa 1e-11 -15.006684983512798 SPR TBD 6lpb N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/HORMONE 01/09/20 Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein HOMO SAPIENS; RATTUS NORVEGICUS; UNIDENTIFIED; BOS TAURUS; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus Kobayashi, K., Shihoya, W., Nishizawa, T., Nureki, O. 3.9 ELECTRON MICROSCOPY False True IGHV3 None None None None None 4p2c K NA 0 F protein NA shiga toxin 2e, subunit b TOXIN 03/03/14 Complex of Shiga toxin 2e with a neutralizing single-domain antibody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Lo, A.W.H., Moonens, K., De Kerpel, M., Brys, L., Pardon, E., Remaut, H., De Greve, H. 2.818 X-RAY DIFFRACTION 0.253 0.187 False True IGHV1 NA NA None None None None None 6grz NA B 0 IMMUNE SYSTEM 06/13/18 Crystal structure of the light chain dimer mH6 HOMO SAPIENS homo sapiens Maritan, M., Ricagno, S., Ambrosetti, A., Oberti, L. 2.1 X-RAY DIFFRACTION 0.238 0.206 False True IGLV1 Lambda None None None None None 6n7j H L 0 C peptide envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/27/18 BDBV223 Fab bound to synthetic peptide of Bundibugyo virus Glycoprotein Stalk HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens bundibugyo ebolavirus King, L.B., West, B.R., Saphire, E.O. 3.684 X-RAY DIFFRACTION 0.254 0.228 False True IGHV4 IGKV3 Kappa None None None None None 3cmo Y X 0 Immune System 03/24/08 HIV neutralizing monoclonal antibody YZ18 MUS MUSCULUS mus musculus mus musculus Jin, L., Prasad, V., Paul, S. 2.3 X-RAY DIFFRACTION 0.287 0.248 False False IGHV1 IGKV10 Kappa None None None None None 3eo1 E D 0 F protein transforming growth factor beta-3 IMMUNE SYSTEM/CYTOKINE 09/26/08 Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Gruetter, C., Gruetter, M.G. 3.1 X-RAY DIFFRACTION 0.279 0.255 False True IGHV1 IGKV8 Kappa 2.50e-10 -13.09 Other 19073914 5c9k NA B 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 2h2p C D 0 A protein clc cl transporter ION TRANSPORT 05/19/06 Crystal structure of CLC-ec1 in complex with Fab fragment in SeCN- ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Nguitragool, W., Miller, C. 3.1 X-RAY DIFFRACTION 0.280 0.278 False False IGHV4 IGKV4 Kappa None None None None None 2a1w I M 0 IMMUNE SYSTEM 06/21/05 Anti-cocaine antibody 7.5.21, crystal form I MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Ringe, D., Petsko, G.A. 2.7 X-RAY DIFFRACTION 0.247 0.185 False False IGHV5 IGKV1 Kappa None None None None None 2bjm H L 0 H Hapten ANF ANTHRONE ANTIBODY 02/04/05 SPE7:Anthrone Complex RATTUS RATTUS rattus rattus rattus rattus rattus rattus Tawfik, Leo C James Dan S 2.15 X-RAY DIFFRACTION 0.286 0.268 False True IGHV1 IGLV1 Lambda 0.00019999999999999998 -5.046297965321237 Unknown TBD 4nc0 B NA 0 A protein cell wall-binding repeat protein IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A2 Bound to A26.8 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 2.3 X-RAY DIFFRACTION 0.223 0.199 False True IGHV1 None None None None None 5vl3 C D 0 S protein b-cell receptor cd22 IMMUNE SYSTEM 04/24/17 CD22 d1-d3 in complex with therapeutic Fab Epratuzumab HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Sicard, T., Ereno-Orbea, J., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.295 0.280 False True IGHV1 IGKV8 Kappa None None None None None 3b9v A NA 0 IMMUNE SYSTEM 11/06/07 Crystal Structure of an Autonomous VH Domain HOMO SAPIENS homo sapiens Appleton, B.A., Barthelemy, P.A., Wiesmann, C. 1.8 X-RAY DIFFRACTION 0.200 0.155 False True IGHV3 None None None None None 5hj3 A B 0 P | O protein | protein NA | NA envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/12/16 Crystal structure of host-primed Ebola virus GP, GPcl. EBOLA VIRUS SP.; ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus | ebola virus sp. Bornholdt, Z.A., Fusco, M.L., Saphire, E.O. 3.3 X-RAY DIFFRACTION 0.258 0.227 False True IGHV3 IGKV4 Kappa None None None None None 3cm9 B M 7 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4mxw H L 0 A protein lymphotoxin-alpha CYTOKINE/IMMUNE SYSTEM 09/26/13 Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sudhamsu, J., Yin, J.P., Hymowitz, S.G. 3.6 X-RAY DIFFRACTION 0.296 0.231 False True IGHV3 IGKV1 Kappa None None None None None 1y18 F E 0 E Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/17/04 Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.252 0.215 False True IGHV4 IGLV1 Lambda None None None None None 4m1d I M 0 Q peptide cyclic v3 arch peptide IMMUNE SYSTEM 08/02/13 Crystal structure of anti-HIV-1 Fab 447-52D in complex with V3 cyclic peptide MN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Killikelly, A., Kong, X.P. 1.8 X-RAY DIFFRACTION 0.216 0.186 False True IGHV3 IGLV1 Lambda 2.3e-08 -10.420467653019871 Unknown TBD 3nh7 J N 0 C protein bone morphogenetic protein receptor type-1a IMMUNE SYSTEM 06/14/10 Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mueller, T.D., Harth, S., Sebald, W. 2.7 X-RAY DIFFRACTION 0.280 0.234 False True IGHV3 IGLV3 Lambda 2.00e-08 -10.5 SPR 25 20927405 1oay J N 0 J Hapten FUR FURAZOLIDONE IMMUNE SYSTEM 01/21/03 Antibody multispecificity mediated by conformational diversity RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.66 X-RAY DIFFRACTION 0.280 0.258 False True IGHV1 IGLV1 Lambda 1.20e-06 Other 20 12610298 6e5p 2 1 0 2 carbohydrate NAG polysaccharide VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens homo sapiens Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 4p9h H L 0 G protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/04/14 Crystal structure of 8ANC195 Fab in complex with gp120 of 93TH057 HIV-1 and soluble CD4 D1D2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Bjorkman, P.J. 3.0 X-RAY DIFFRACTION 0.272 0.235 False True unknown IGKV1 Kappa None None None None None 6did D C 0 F | I protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN 05/23/18 HIV Env BG505 SOSIP with polyclonal Fabs from immunized rabbit #3417 post-boost#1 HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Turner, H.L., Cottrell, C.A., Oyen, D., Wilson, I.A., Ward, A.B. 4.71 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7aqg C NA 0 A protein NA plasminogen activator inhibitor 1 HYDROLASE 10/21/20 Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Strelkov, S.V., Declerck, P.J. 2.27 X-RAY DIFFRACTION 0.268 0.215 False True IGHV1 NA NA None None None None None 7kqg B C 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/16/20 Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Bajic, G., Harrison, S.C. 2.6 X-RAY DIFFRACTION 0.280 0.232 False True IGHV3 IGKV1 Kappa None None None None None 6x8u H L 0 P peptide NA mixed peptide IMMUNE SYSTEM 06/01/20 Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein Mixed peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium berghei anka Thai, E., Julien, J.P. 1.55 X-RAY DIFFRACTION 0.180 0.164 False True IGHV1 IGKV1 Kappa None None None None None 6ous O P 0 D | C protein | protein NA | NA fusion glycoprotein f1 fused with fibritin trimerizationdomain | fusion glycoprotein f2 VIRAL PROTEIN/Immune system 05/05/19 Structure of fusion glycoprotein from human respiratory syncytial virus HUMAN RESPIRATORY SYNCYTIAL VIRUS A2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a2, humanimmunodeficiency virus 1 | human respiratory syncytial virus a2 Su, H.P. 3.4 X-RAY DIFFRACTION 0.275 0.245 False True IGHV3 IGKV1 Kappa None None None None None 5any J N 0 D | C protein | protein NA | NA e2 | e1 VIRUS 09/08/15 Electron cryo-microscopy of chikungunya virus in complex with neutralizing antibody Fab CHK265 CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Fox, J.M., Long, F., Edeling, M.A., Lin, H., Duijl-Richter, M., Fong, R.H., Kahle, K.M., Smit, J.M., Jin, J., Simmons, G., Doranz, B.J., Crowe, J.E., Fremont, D.H., Rossmann, M.G., Diamond, M.S. 16.9 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 4pou B NA 0 A protein ribonuclease pancreatic Hydrolase/Immune System 02/26/14 VHH-metal in Complex with RNase A LAMA GLAMA; BOS TAURUS lama glama bos taurus Fanning, S.W., Walter, R., Horn, J.R. 1.75 X-RAY DIFFRACTION 0.230 0.182 False True IGHV1 1.5700000000000002e-07 -9.282453682954959 ITC TBD 2jix F A 0 C | B protein | protein NA | NA erythropoietin receptor | erythropoietin receptor RECEPTOR/IMMUNE SYSTEM 07/02/07 Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor ESCHERICHIA COLI; HOMO SAPIENS homo sapiens | homo sapiens Liu, Z., Stoll, V.S., DeVries, P., Jakob, C.G., Xie, N., Simmer, R.L., Lacy, S.E., Egan, D.A., Harlan, J.E., Lesniewski, R.R., Reilly, E.B. 3.2 X-RAY DIFFRACTION 0.323 0.257 False True IGHV4 IGKV1 Kappa 3.00e-08 -10.26 SPR 17620453 6nmu B A 0 C protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Kick-Off Fab 115 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.55 X-RAY DIFFRACTION 0.261 0.193 False True IGHV3 IGKV3 Kappa None None None None None 1bzq M NA 0 C protein protein (rnase a) HYDROLASE/IMMUNE SYSTEM 11/03/98 COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Decanniere, K., Desmyter, A., Gahroudhi, M., Lauwereys, M., Muyldermans, S., Wyns, L. 2.8 X-RAY DIFFRACTION 0.282 0.222 False True IGHV1 None None None None None 7mxe M O 0 C | P protein | protein NA | NA hiv-1 envelope glycoprotein bg505 sosip.664 gp41 | envelope glycoprotein bg505 sosip.664 gp120 ANTIVIRAL PROTEIN/VIRAL PROTEIN 05/19/21 Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Abernathy, M.E., Bjorkman, P.J. 3.7 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7bu8 J K 0 C protein genome polyprotein VIRUS 05/13/20 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6zqk C NA 0 NA NA NA NA ANTITUMOR PROTEIN 07/09/20 HER2-binding scFv-Fab fusion 841 MUS MUSCULUS mus musculus Kast, F., Schwill, M., Stueber, J.C., Pfundstein, S., Nagy-Davidescu, G., Monne Rodriguez, J.M., Seehusen, F., Richter, C.P., Honegger, A., Hartmann, K.P., Weber, T.G., Kroener, F., Ernst, P., Piehler, J., Plueckthun, A. 2.2 X-RAY DIFFRACTION 0.241 0.202 False True IGHV3 NA NA None None None None None 7ns6 T NA 0 I protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/05/21 SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4 vicugna pacos severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Das, H., Hallberg, B.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7lo6 L K 0 A protein NA envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/09/21 Structure of CD4 mimetic BNM-III-170 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Jette, C.A., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4plj H L 0 A protein capsid protein VIRAL PROTEIN/IMMUME SYSTEM 05/18/14 Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing antibody 8G12 HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Li, S.W., Sivaraman, J. 2.3 X-RAY DIFFRACTION 0.242 0.187 False False IGHV1 IGKV12 Kappa None None None None None 3mug J I 0 I carbohydrate NAG polysaccharide IMMUNE SYSTEM 05/03/10 Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pejchal, R., Walker, L.M., Burton, D.R., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGLV2 Lambda None None None None None 4hqq H L 0 Immune System 10/25/12 Crystal structure of RV144-elicited antibody CH58 HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Haynes, B.F., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.225 0.183 False True IGHV5 IGLV6 Lambda None None None None None 4lci H L 0 IMMUNE SYSTEM 06/21/13 Anti canine CD28 antibody, 1C6 CANIS LUPUS FAMILIARIS canis lupus familiaris canis lupus familiaris Gewe, M.M., Rupert, P.B., Strong, R.K. 1.9 X-RAY DIFFRACTION 0.230 0.179 False True IGHV9 IGKV2 Kappa None None None None None 5feh D C 0 IMMUNE SYSTEM 12/17/15 Crystal structure of PCT64_35B, a broadly neutralizing anti-HIV antibody HOMO SAPIENS homo sapiens homo sapiens Murrell, S., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.279 0.259 False True IGHV3 IGKV3 Kappa None None None None None 4kk6 E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of CLC-ec1 deltaNC construct in 20mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.183 X-RAY DIFFRACTION 0.269 0.235 False True IGHV4 IGKV4 Kappa None None None None None 5wdf A B 0 Q peptide hiv-1 gp41 peptide IMMUNE SYSTEM 07/05/17 Crystal structure of 10E8v4-5R+100cF Fab in complex with HIV-1 gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.281 0.247 False True IGHV3 IGLV3 Lambda None None None None None 6e1k F E 0 A protein two pore calcium channel protein 1 MEMBRANE PROTEIN 07/10/18 Structure of AtTPC1(DDE) reconstituted in saposin A with cat06 Fab ARABIDOPSIS THALIANA; HOMO SAPIENS homo sapiens homo sapiens arabidopsis thaliana Kintzer, A.F., Green, E.M., Cheng, Y., Stroud, R.M. 3.3 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6obz A B 0 IMMUNE SYSTEM 03/21/19 Crystal structure of FluA-20 Fab HOMO SAPIENS homo sapiens homo sapiens Wilson, I.A., Lang, S. 1.73 X-RAY DIFFRACTION 0.238 0.202 False True IGHV4 IGKV1 Kappa None None None None None 7czz I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2F11_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 5fec H L 0 I protein 426c.tm4deltav1-3 gp120 IMMUNE SYSTEM 12/16/15 Crystal structure of 3BNC60 Fab germline precursor in complex with 426c.TM4deltaV1-3 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Bjorkman, P.J. 3.17 X-RAY DIFFRACTION 0.266 0.202 False True IGHV1 IGKV1 Kappa None None None None None 7n0x H L 0 G peptide NA glycoprotein 120 IMMUNE SYSTEM 05/26/21 Rhesusized RV144 DH827 Fab bound to HIV-1 Env V2 peptide MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 2.0 X-RAY DIFFRACTION 0.209 0.181 False True IGHV3 IGLV3 Lambda None None None None None 3jbq h l 0 B protein phosphodiesterase 5/6 chimera catalytic domain HYDROLASE/IMMUNE SYSTEM 09/17/15 Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6 MUS MUSCULUS; BOS TAURUS mus musculus mus musculus bos taurus Zhang, Z., He, F., Constantine, R., Baker, M.L., Baehr, W., Schmid, M.F., Wensel, T.G., Agosto, M.A. 11 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa None None None None None 4iml H L 0 IMMUNE SYSTEM 01/03/13 CrossFab binding to human Angiopoietin 2 HOMO SAPIENS homo sapiens homo sapiens Fenn, S., Schiller, C., Griese, J., Hopfner, K.-P., Kettenberger, H. 2.931 X-RAY DIFFRACTION 0.269 0.237 False True IGHV1 IGLV3 Lambda None None None None None 7oan G NA 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN 04/19/21 Nanobody C5 bound to Spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Naismith, J.H., Weckener, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7kd6 O P 0 Q protein NA insulin receptor subunit alpha SIGNALING PROTEIN 10/08/20 Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G. 2.6 X-RAY DIFFRACTION 0.221 0.189 False True IGHV2 IGKV8 Kappa None None None None None 6i07 A a 0 C protein epithelial cell adhesion molecule IMMUNE SYSTEM 10/25/18 Crystal structure of EpCAM in complex with scFv HOMO SAPIENS homo sapiens homo sapiens Casaletto, J.B., Geddie, M.L., Abu-Yousif, A.O., Masson, K., Fulgham, A., Boudot, A., Maiwald, T., Kearns, J.D., Kohli, N., Su, S., Razlog, M., Raue, A., Kalra, A., Hakansson, M., Logan, D.T., Welin, M., Chattopadhyay, S., Harms, B.D., Nielsen, U.B., Schoeberl, B., Lugovskoy, A.A., MacBeath, G. 2.35 X-RAY DIFFRACTION 0.279 0.230 True True unknown unknown unknown None None None None None 5a8h L K 0 G protein NA hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 23.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6df0 H L 0 IMMUNE SYSTEM 05/13/18 anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with sulfate SYNTHETIC CONSTRUCT synthetic construct synthetic construct Mou, K., Leung, K., Wells, J.A. 2.3 X-RAY DIFFRACTION 0.244 0.200 False True IGHV3 IGKV1 Kappa None None None None None 6mpg W B 0 U protein envelope glycoprotein gp41 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False True IGHV3 IGKV4 Kappa None None None None None 5thr N K 0 E protein bg505 sosip gp120 VIRAL PROTEIN 09/30/16 Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 8.9, 8.9 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7pqz H L 0 E protein NA spike protein s1 VIRAL PROTEIN 09/20/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FI-3A and FD-11A Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.2 X-RAY DIFFRACTION 0.240 0.201 False True IGHV3 IGKV1 Kappa None None None None None 6mn7 H h 0 D protein envelope glycoprotein gp120 VIRAL PROTEIN 10/01/18 Cryo-EM structure of BG505.SOSIP.664 in complex with BF520.1 antigen binding fragment HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens human immunodeficiency virus 1 Williams, J.A., Lee, K.K., Overbaugh, J. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6jb2 A NA 0 B protein lysozyme c IMMUNE SYSTEM/HYDROLASE 01/25/19 Crystal structure of nanobody D3-L11 mutant Y102A in complex with hen egg-white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Caaveiro, J.M.M., Tamura, H., Akiba, H., Tsumoto, K. 1.5 X-RAY DIFFRACTION 0.165 0.125 False True IGHV1 None None None None None 5jo5 H L 0 IMMUNE SYSTEM 05/02/16 Crystal structure of 10E8 gHV-gLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.263 0.233 False True IGHV3 IGLV3 Lambda None None None None None 3nig E F 0 C protein integrin alpha-iib CELL ADHESION/BLOOD CLOTTING 06/15/10 The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.25 X-RAY DIFFRACTION 0.212 0.172 False True IGHV14 IGKV14 Kappa None None None None None 6w1c I M 0 F | B protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRUS/IMMUNE SYSTEM 03/04/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain MAYARO VIRUS (STRAIN BRAZIL); HOMO SAPIENS homo sapiens homo sapiens mayaro virus (strain brazil) | mayaro virus (strain brazil) Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 6ea5 H L 0 F | A protein | protein NA | NA glycoprotein | envelope glycoprotein VIRAL PROTEIN/immune system 08/02/18 Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878 BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus | bundibugyo ebolavirus King, L.B., West, B.R., Moyer, C.L., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O. 4.75 X-RAY DIFFRACTION 0.305 0.295 False True IGHV3 IGKV1 Kappa None None None None None 7whk E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6ikm D d 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 7d4g N G 0 B protein NA spike glycoprotein s1 VIRAL PROTEIN 09/23/20 A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cao, L., Wang, X. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 3dus D C 0 C carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/17/08 Crystal structure of SAG506-01, orthorhombic, twinned, crystal 1 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.282 0.253 False True IGHV7 IGKV8 Kappa None None None None None 7qcq A NA 0 B peptide NA unknown IMMUNE SYSTEM 11/25/21 VHH Z70 in interaction with PHF6 Tau peptide LAMA GLAMA Danis, C., Dupre, E., Zejneli, O., Caillierez, R., Arrial, A., Begard, S., Loyens, A., Mortelecque, J., Cantrelle, F.-X., Hanoulle, X., Rain, J.-C., Colin, M., Buee, L., Landrieu, I. 1.7 X-RAY DIFFRACTION 0.214 0.195 False False IGHV3 NA NA None None None None None 6hhd D NA 0 C protein major prion protein PROTEIN BINDING 08/28/18 Mouse Prion Protein in complex with Nanobody 484 MUS MUSCULUS; CAMELUS DROMEDARIUS camelus dromedarius mus musculus Soror, S., Abskharon, R., Wohlkonig, A. 2.102 X-RAY DIFFRACTION 0.245 0.206 False True IGHV1 None None None None None 7ora A B 0 R protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the T478K mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-45 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.6 X-RAY DIFFRACTION 0.245 0.204 False True IGHV3 IGKV1 Kappa None None None None None 7s6k H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 09/14/21 J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3w2d H L 0 A protein enterotoxin type b IMMUNE SYSTEM 11/28/12 Crystal Structure of Staphylococcal Eenterotoxin B in complex with a novel neutralization monoclonal antibody Fab fragment STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Liang, S.Y., Hu, S., Dai, J.X., Guo, Y.J., Lou, Z.Y. 3.1 X-RAY DIFFRACTION 0.261 0.196 False True IGHV3 IGKV4 Kappa 5.787000000000001e-10 -12.60226823733781 SPR TBD 7deu B b 0 A protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 11/05/20 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Zhang, Z., Zhang, G., Li, X., Rao, Z., Guo, Y. 2.1 X-RAY DIFFRACTION 0.229 0.209 True True unknown unknown unknown None None None None None 7o31 H L 0 P peptide NA pas#1 epitope peptide IMMUNE SYSTEM 04/01/21 Crystal structure of the anti-PAS Fab 1.2 in complex with its epitope peptide and the anti-Kappa VHH domain MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Schilz, J., Schiefner, A., Skerra, A. 1.55 X-RAY DIFFRACTION 0.232 0.194 False True IGHV5 IGKV3 Kappa None None None None None 3ri5 H L 0 A protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.4 X-RAY DIFFRACTION 0.248 0.232 False True IGHV1 IGLV1 Lambda None None None None None 1g9e A NA 11 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6u0n H L 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN 08/14/19 Asymmetrically open conformational state (Class II) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 4z0b H L 0 IMMUNE SYSTEM 03/26/15 Crystal Structure of the Fab Fragment of Anti-ofloxacin Antibody and Exploration Its Receptor Binding Site MUS MUSCULUS mus musculus mus musculus He, K., Du, X., Sheng, W., Zhou, X., Wang, J., Wang, S. 3.2 X-RAY DIFFRACTION 0.309 0.276 False True IGHV5 IGKV4 Kappa None None None None None 4kjw C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN, membrane protein 05/03/13 Structure of the CLC-ec1 deltaNC construct in 100mM fluoride and 20mM bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.03 X-RAY DIFFRACTION 0.269 0.230 False True IGHV4 IGKV4 Kappa None None None None None 5dfz E NA 0 C protein phosphatidylinositol 3-kinase vps34 TRANSFERASE 08/27/15 Structure of Vps34 complex II from S. cerevisiae. SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); LAMA GLAMA lama glama saccharomyces cerevisiae (strain atcc 204508 /s288c) Rostislavleva, K., Soler, N., Ohashi, Y., Zhang, L., Williams, R.L. 4.4 X-RAY DIFFRACTION 0.376 0.368 False True IGHV1 None None None None None 6svl G I 0 J protein myeloid-derived growth factor CYTOKINE 09/18/19 human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ebenhoch, R., Nar, H. 1.58 X-RAY DIFFRACTION 0.206 0.181 False True IGHV14 IGKV12 Kappa None None None None None 4fqi H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal Structure of Fab CR9114 in Complex with a H5N1 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Dreyfus, C., Wilson, I.A. 1.71 X-RAY DIFFRACTION 0.232 0.198 False True IGHV1 IGLV1 Lambda 9e-10 -12.340621190735936 BLI TBD 4r4n C D 0 B | p protein | peptide NA | NA m48u1 peptide | unknown VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | synthetic construct Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 7k7i M N 0 C protein NA putative pertussis-like toxin subunit TOXIN 09/22/20 Density-fitted Model Structure of Antibody Variable Domains of TyTx4 in Complex with PltB pentamer of Typhoid Toxin SALMONELLA TYPHI; MUS MUSCULUS mus musculus mus musculus salmonella typhi Nguyen, T., Feathers, J.R., Fromme, J.C., Song, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 1q9l D C 0 IMMUNE SYSTEM 08/25/03 S25-2 Fab Unliganded 2 MUS MUSCULUS mus musculus mus musculus Nguyen, H.P., Seto, N.O., MacKenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 2.28 X-RAY DIFFRACTION 0.286 0.216 False False IGHV7 IGKV8 Kappa None None None None None 1op9 A NA 0 B protein lysozyme c HYDROLASE 03/05/03 Complex of human lysozyme with camelid VHH HL6 antibody fragment CAMELUS DROMEDARIUS; HOMO SAPIENS camelus dromedarius homo sapiens Dumoulin, M., Last, A.M., Desmyter, A., Decanniere, K., Canet, D., Larsson, G., Spencer, A., Archer, D.B., Sasse, J., Muyldermans, S., Wyns, L., Redfield, C., Matagne, A., Robinson, C.V., Dobson, C.M. 1.86 X-RAY DIFFRACTION 0.238 0.196 False True IGHV1 7.00e-10 -12.48 SPR 25 12917687 7db6 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 10/19/20 human melatonin receptor MT1 - Gi1 complex HOMO SAPIENS; RATTUS RATTUS; BOS TAURUS; MUS MUSCULUS mus musculus homo sapiens | rattus rattus Okamoto, H.H., Kusakizako, T., Shihioya, W., Yamashita, K., Nishizawa, T., Nureki, O. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5xhf B A 0 NA NA NA NA IMMUNE SYSTEM 04/20/17 Crystal structure of Trastuzumab Fab fragment bearing p-azido-L-phenylalanine MUS MUSCULUS mus musculus mus musculus Kuratani, M., Yanagisawa, T., Sakamoto, K., Yokoyama, S. 3.205 X-RAY DIFFRACTION 0.297 0.219 False True IGHV3 IGKV1 Kappa None None None None None 7whj F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 1 complex structure of Omicron spike with Bn03 (1-up RBD, 3 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6wps F G 0 E protein sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/27/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., De Marco, A., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7a0y E F 0 B protein NA na(+)/h(+) antiporter nhaa MEMBRANE PROTEIN 08/11/20 Structure of dimeric sodium proton antiporter NhaA K300R variant, at pH 8.2, crystallized with chimeric Fab antibodies SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM STR. LT2; GALLUS GALLUS; HOMO SAPIENS gallus gallus, homo sapiens gallus gallus, homo sapiens salmonella enterica subsp. enterica serovartyphimurium str. lt2 Fippel, A., Mir, S.H., Lentes, C.J., Wirth, C., Hunte, C. 2.45 X-RAY DIFFRACTION 0.241 0.203 False True unknown unknown unknown None None None None None 6oq5 D NA 0 A protein toxin b TOXIN 04/25/19 Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs CLOSTRIDIOIDES DIFFICILE; CAMELIDAE camelidae clostridioides difficile Chen, P., Lam, K., Jin, R. 3.87 X-RAY DIFFRACTION 0.315 0.263 False True IGHV1 None None None None None 6o3u F E 0 H Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 02/27/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with 06:0 PA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Wilson, I.A. 3.105 X-RAY DIFFRACTION 0.228 0.186 False True IGHV1 IGKV3 Kappa None None None None None 7n0g X NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/25/21 CryoEm structure of SARS-CoV-2 spike protein (S-6P, 1-up) in complex with sybodies (Sb45) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Huang, R., Margulies, D. 3.02 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6gs1 H NA 0 A protein dipeptide and tripeptide permease a MEMBRANE PROTEIN 06/13/18 Crystal structure of peptide transporter DtpA-nanobody in MES buffer ESCHERICHIA COLI (STRAIN K12); LAMA GLAMA lama glama escherichia coli (strain k12) Ural-Blimke, Y., Flayhan, A., Loew, C., Quistgaard, E.M. 3.29 X-RAY DIFFRACTION 0.263 0.252 False True IGHV1 None None None None None 6zwk B NA 0 H peptide NA histone h2ax IMMUNE SYSTEM 07/28/20 Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens McEwen, A.G., Moeglin, E., Desplancq, D., Weiss, E., Poterszman, A. 1.55 X-RAY DIFFRACTION 0.184 0.149 False True IGHV1 NA NA None None None None None 6qd8 Q Y 0 B | A protein | protein NA | NA envelope glycoprotein | envelope glycoprotein,virion spike glycoprotein,ebov-gp1 VIRAL PROTEIN 01/01/19 EM structure of a EBOV-GP bound to 4M0368 neutralizing antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus | ebola virus Diskin, R., Cohen-Dvashi, H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 1kno F E 0 F Hapten PNP METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER CATALYTIC ANTIBODY 09/11/95 CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES MUS MUSCULUS mus musculus mus musculus mus musculus Charbonnier, J.-B., Gigant, B., Knossow, M. 3.2 X-RAY DIFFRACTION 0.272 0.200 False False IGHV5 IGKV9 Kappa None None None None None 5y2k E F 0 IMMUNE SYSTEM 07/26/17 A human antibody AF4H1L1 HOMO SAPIENS homo sapiens homo sapiens Xiao, H., Qi, J., Gao, F.G. 2.1 X-RAY DIFFRACTION 0.259 0.220 False True IGHV3 IGLV3 Lambda None None None None None 6gdg E NA 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/23/18 Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer ESCHERICHIA COLI; HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Garcia-Nafria, J., Lee, Y. 4.11 ELECTRON MICROSCOPY False True IGHV3 None None None None None 3lrh NA C 0 D peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 6x5n H L 0 R nucleic-acid NA ggpan rna (39-mer) Immune System/RNA 05/26/20 Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Swain, M., Li, M., Woldawer, A., LeGrice, S.F.J. 3.3 X-RAY DIFFRACTION 0.267 0.180 False True IGHV3 IGKV1 Kappa None None None None None 7mep N K 0 D | B protein | protein NA | NA bg505 sosipv5.2(7s) - gp120 | bg505 sosipv5.2(7s) - gp120 VIRAL PROTEIN 04/07/21 BG505 SOSIP.v5.2(7S) in complex with the monoclonal antibodies Rh.33172 mAb.1 and RM19R MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS macaca mulatta macaca mulatta human immunodeficiency virus | human immunodeficiency virus Antanasijevic, A., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4cdg D NA 0 B protein bloom syndrome protein 10/31/13 Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Newman, J.A., Savitsky, P., Allerston, C.K., Pike, A.C.W., Pardon, E., Steyaert, J., Arrowsmith, C.H., Von Delft, F., Bountra, C., Edwards, A., Gileadi, O. 2.794 X-RAY DIFFRACTION 0.2455 0.2056 False True IGHV1 None None None None None 7q6z B NA 0 A protein NA protein-cysteine n-palmitoyltransferase hhat MEMBRANE PROTEIN 11/09/21 Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575 HOMO SAPIENS; ESCHERICHIA COLI K-12 escherichia coli k-12 homo sapiens Coupland, C., Carrique, L., Siebold, C. 3.59 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6cwg B NA 0 A protein ricin IMMUNE SYSTEM 03/30/18 Ricin catalytic subunit bound go A9 VHH antibody RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Mantis, N. 2.6 X-RAY DIFFRACTION 0.262 0.223 False True IGHV1 None None None None None 7pc2 O P 0 B protein NA gp120, bg505 sosip.664 t332n VIRAL PROTEIN 08/03/21 HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Fernandez, I., Bontems, F., Pehau-Arnaudet, G., Rey, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4gxu S T 0 G protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/04/12 Crystal structure of antibody 1F1 bound to the 1918 influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 3.294 X-RAY DIFFRACTION 0.255 0.219 False True IGHV3 IGLV1 Lambda 6.24e-09 SPR 23236279 7ljb E D 0 A protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.97 X-RAY DIFFRACTION 0.240 0.196 False True IGHV1 IGKV4 Kappa None None None None None 6x78 H L 0 G peptide NA hiv fusion peptide 512-519 v2 IMMUNE SYSTEM/VIRAL PROTEIN 05/29/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP48.03 in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Kwong, P.D. 2.359 X-RAY DIFFRACTION 0.226 0.178 False True IGHV1 IGKV1 Kappa None None None None None 7rtb N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/12/21 Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R) HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Johnson, R.M., Danev, R., Sexton, P.M., Wootten, D. 2.14 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4hkz B A 0 H | E protein | protein NA | NA immunoglobulin g-binding protein a | protein l fragment immune system 10/15/12 Trastuzumab Fab complexed with Protein L and Protein A fragments HOMO SAPIENS; STAPHYLOCOCCUS AUREUS; FINEGOLDIA MAGNA homo sapiens homo sapiens staphylococcus aureus | finegoldia magna Avery, K.N., Zer, C., Bzymek, K.P., Williams, J.C. 2.08 X-RAY DIFFRACTION 0.206 0.162 False True IGHV3 IGKV1 Kappa None None None None None 4lvh B C 0 A protein hemagglutinin IMMUNE SYSTEM 07/26/13 Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J.-H. 2.8 X-RAY DIFFRACTION 0.274 0.232 False False IGHV5 IGKV3 Kappa None None None None None 5i4f A a 0 a Hapten 6DM 6-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose IMMUNE SYSTEM 02/12/16 scFv 2D10 complexed with alpha 1,6 mannobiose MUS MUSCULUS mus musculus Vashisht, S., Kumar, A., Kaur, K.J., Salunke, D.M. 1.549 X-RAY DIFFRACTION 0.193 0.167 True True unknown unknown unknown None None None None None 2mmx NA A 4 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6wzt H L 0 A protein NA hemagglutinin ANTIVIRAL PROTEIN 05/14/20 CryoEM structure of influenza hemagglutinin A/Victoria/361/2011 in complex with cyno antibody 3B10 INFLUENZA A VIRUS; MACACA FASCICULARIS macaca fascicularis macaca fascicularis influenza a virus Qiu, Y., Zhou, Y., Darricarrere, N. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5w6d H L 0 G protein bg505-sosip.v4.1-gt1-n137a gp120 VIRAL PROTEIN/Immune System 06/16/17 Crystal structure of BG505-SOSIP.v4.1-GT1-N137A in complex with Fabs 35022 and 9H/109L HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Garces, F., Stanfield, R.L., Wilson, I.A. 3.202 X-RAY DIFFRACTION 0.267 0.242 False True IGHV4 unknown unknown None None None None None 6xlz H L 0 P | A peptide | peptide NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 IMMUNE SYSTEM 06/29/20 Structure of NHP D11A.F2 Fab in complex with 16055 V2b peptide HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Aljedani, S., Rodarte, J., Liban, T., Pancera, M. 2.8 X-RAY DIFFRACTION 0.255 0.216 False True IGHV4 IGLV6 Lambda None None None None None 6eyn B A 0 IMMUNE SYSTEM 11/13/17 Structure of the 8D6 (anti-IgE) Fab HOMO SAPIENS homo sapiens homo sapiens Chen, J.B., Ramadani, F., Pang, M.O.Y., Beavil, R.L., Holdom, M.D., Mitropoulou, A.N., Beavil, A.J., Gould, H.J., Chang, T.W., Sutton, B.J., McDonnell, J.M., Davies, A.M. 2.4 X-RAY DIFFRACTION 0.212 0.181 False True IGHV1 IGKV3 Kappa None None None None None 2kh2 B b 22 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7bep D F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-384 and S309 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.61 X-RAY DIFFRACTION 0.241 0.203 False True IGHV3 IGKV1 Kappa None None None None None 6y54 O P 0 P unknown OA8 unknown IMMUNE SYSTEM 02/24/20 Crystal structure of a Neisseria meningitidis serogroup A capsular oligosaccharide bound to a functional Fab MUS MUSCULUS mus musculus mus musculus mus musculus Dello Iacono, L., Henriques, P., Adamo, R. 2.67 X-RAY DIFFRACTION 0.267 0.210 False True IGHV1 IGKV1 Kappa None None None None None 1n8z B A 0 C protein receptor protein-tyrosine kinase erbb-2 TRANSFERASE 11/21/02 Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cho, H.-S., Mason, K., Ramyar, K.X., Stanley, A.M., Gabelli, S.B., Denney Jr., D.W., Leahy, D.J. 2.52 X-RAY DIFFRACTION 0.284 0.222 False True IGHV3 IGKV1 Kappa None None None None None 1fn4 D C 0 IMMUNE SYSTEM 08/21/00 CRYSTAL STRUCTURE OF FAB198, AN EFFICIENT PROTECTOR OF ACETYLCHOLINE RECEPTOR AGAINST MYASTHENOGENIC ANTIBODIES RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Poulas, K., Eliopoulos, E., Vatzaki, E., Navaza, J., Kontou, M. 2.8 X-RAY DIFFRACTION 0.294 0.198 False False IGHV2 IGKV22 Kappa None None None None None 4jn2 H L 0 L Hapten C24 3-({2-[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-3-METHYL-3H-BENZOIMIDAZOLE-5-CARBONYL}-PYRIDIN-2-YL-AMINO)-PROPIONIC ACID ETHYL ESTER immune system/inhibitor 03/14/13 An Antidote for Dabigatran MUS MUSCULUS mus musculus mus musculus mus musculus Schiele, F., Nar, H. 1.71 X-RAY DIFFRACTION 0.182 0.167 False True IGHV4 IGKV2 Kappa 2.1e-12 -15.931343304588362 Unknown TBD 5w05 H L 0 IMMUNE SYSTEM 05/30/17 ANTI-TISSUE FACTOR ANTIBODY M59, A HUMANIZED VERSION OF 10H10 MUS MUSCULUS mus musculus mus musculus Teplyakov, A., Obmolova, G., Malia, T.J., Gilliland, G.L. 1.64 X-RAY DIFFRACTION 0.204 0.187 False True IGHV5 IGKV2 Kappa None None None None None 6umh H L 0 IMMUNE SYSTEM 10/09/19 Crystal structure of erenumab Fab-a HOMO SAPIENS homo sapiens homo sapiens Mohr, C. 2.15 X-RAY DIFFRACTION 0.224 0.185 False True IGHV3 IGLV1 Lambda None None None None None 5eul V NA 0 Y | E protein | protein NA | NA protein translocase subunit secy | preprotein translocase sece subunit PROTEIN TRANSPORT 11/18/15 Structure of the SecA-SecY complex with a translocating polypeptide substrate VICUGNA PACOS; GEOBACILLUS THERMODENITRIFICANS (STRAIN NG80-2); BACILLUS SUBTILIS (STRAIN 168) vicugna pacos geobacillus thermodenitrificans (strain ng80-2) | geobacillus thermodenitrificans (strain ng80-2) Li, L., Park, E., Ling, J., Ingram, J., Ploegh, H., Rapoport, T.A. 3.7 X-RAY DIFFRACTION 0.315 0.295 False True IGHV1 None None None None None 5c9k NA D 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 7zwm B C 0 A protein NA gametocyte surface protein p45/48 CELL ADHESION 05/19/22 Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 3.69 X-RAY DIFFRACTION 0.280 0.255 False True IGHV5 IGKV4 Kappa None None None None None 5ihz C D 0 IMMUNE SYSTEM 03/01/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.64 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGLV4 Lambda None None None None None 6ffj A a 0 ANTITUMOR PROTEIN 01/08/18 Anti-tumor antibody 14F7-derived single chain fragment variable (scFv) HOMO SAPIENS homo sapiens Bjerregaard-Andersen, K., Heggelund, J.E., Krengel, U. 2.2 X-RAY DIFFRACTION 0.238 0.184 True True unknown unknown unknown None None None None None 3lmj H L 0 IMMUNE SYSTEM 01/30/10 Structure of human anti HIV 21c Fab HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Marcovecchio, P.M., Bjorkman, P.J. 2.2 X-RAY DIFFRACTION 0.219 0.193 False True IGHV1 IGLV1 Lambda None None None None None 6yxk A B 0 C peptide NA citrullinated vimentin (59-74) IMMUNE SYSTEM 05/03/20 Crystal structure of ACPA 3F3 in complex with cit-vimentin 59-74 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Ge, C., Holmdahl, R. 2.0 X-RAY DIFFRACTION 0.253 0.211 False True unknown IGKV4 Kappa None None None None None 3wfd H L 0 B | C protein | protein NA | NA nitric oxide reductase subunit b | nitric oxide reductase subunit c IMMUNE SYSTEM/OXIDOREDUCTASE 07/18/13 Reduced and acetaldoxime-bound cytochrome c-dependent nitric oxide reductase (cNOR) from Pseudomonas aeruginosa in complex with antibody fragment MUS MUSCULUS; PSEUDOMONAS AERUGINOSA mus musculus mus musculus pseudomonas aeruginosa | pseudomonas aeruginosa Sato, N., Ishii, S., Hino, T., Sugimoto, H., Fukumori, Y., Shiro, Y., Tosha, T. 2.3 X-RAY DIFFRACTION 0.232 0.191 False False IGHV1 IGKV16 Kappa None None None None None 6dwi N M 0 NA NA NA NA IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 7ld1 M N 0 C protein NA spike glycoprotein IMMUNE SYSTEM 01/12/21 Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1047 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7kfe G I 0 B protein NA spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-329 HOMO SAPIENS; BUNDIBUGYO EBOLAVIRUS homo sapiens homo sapiens bundibugyo ebolavirus Murin, C.D., Ward, A.B. 6.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1rzi P O 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 3opz H L 0 A protein trans-sialidase hydrolase/immune system 09/02/10 Crystal structure of trans-sialidase in complex with the Fab fragment of a neutralizing monoclonal IgG antibody TRYPANOSOMA CRUZI; MUS MUSCULUS mus musculus mus musculus trypanosoma cruzi Larrieux, N., Muia, R., Campetella, O., Buschiazzo, A. 3.4 X-RAY DIFFRACTION 0.205 0.164 False False IGHV1 IGKV4 Kappa None None None None None 6sc7 C NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-Ligand3 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.56 X-RAY DIFFRACTION 0.267 0.224 False True IGHV3 None None None None None 6oed C D 0 NA NA NA NA IMMUNE SYSTEM 03/27/19 CRYSTAL STRUCTURE OF THE RV144 C1-C2 SPECIFIC ANTIBODY CH55 FAB HOMO SAPIENS homo sapiens homo sapiens Yan, F., Van, V., Tolbert, W.D., Pazgier, M. 2.461 X-RAY DIFFRACTION 0.312 0.256 False True IGHV1 IGKV3 Kappa None None None None None 6ous S T 0 H | G protein | protein NA | NA fusion glycoprotein f1 fused with fibritin trimerizationdomain | fusion glycoprotein f2 VIRAL PROTEIN/Immune system 05/05/19 Structure of fusion glycoprotein from human respiratory syncytial virus HUMAN RESPIRATORY SYNCYTIAL VIRUS A2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a2, humanimmunodeficiency virus 1 | human respiratory syncytial virus a2 Su, H.P. 3.4 X-RAY DIFFRACTION 0.275 0.245 False True IGHV3 IGKV1 Kappa None None None None None 5i2i B A 0 IMMUNE SYSTEM 02/08/16 Structure of cetuximab Fab with cyclic F3Q variant of the meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.551 X-RAY DIFFRACTION 0.205 0.160 False True IGHV2 IGKV5 Kappa None None None None None 7rqr A B 0 C peptide NA pfcsp peptide nanpnvdp IMMUNE SYSTEM 08/06/21 Structure of chimeric antibody L9heavy_F10light with PfCSP peptide NANPNVDP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Hurlburt, N.K., Pancera, M. 2.23 X-RAY DIFFRACTION 0.238 0.189 False True IGHV3 IGKV1 Kappa None None None None None 5awn H L 0 IMMUNE SYSTEM 07/06/15 Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC176 Fab HOMO SAPIENS homo sapiens homo sapiens Lee, J.H., Wilson, I.A., Ward, A.B. 1.887 X-RAY DIFFRACTION 0.223 0.177 False True unknown IGLV2 Lambda None None None None None 5hhx H L 0 A protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 3.0 X-RAY DIFFRACTION 0.263 0.176 False True IGHV3 IGLV6 Lambda 6.16e-09 -11.201015985009631 Unknown TBD 6qd6 F NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 7ben G I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253 and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.5 X-RAY DIFFRACTION 0.282 0.240 False True IGHV3 IGKV1 Kappa None None None None None 3j8d d D 0 F protein glycoprotein diii VIRUS/IMMUNE SYSTEM 10/13/14 Cryoelectron microscopy of dengue-Fab E104 complex at pH 5.5 DENGUE VIRUS 2 THAILAND/16681/84; UNIDENTIFIED unidentified dengue virus 2 thailand/16681/84 Zhang, X.Z., Sheng, J., Austin, S.K., Hoornweg, T., Smit, J.M., Kuhn, R.J., Diamond, M.S., Rossmann, M.G. 26 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 2g5b H G 0 L peptide bax peptide APOPTOSIS 02/22/06 Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Peyerl, F.W., Dai, S., Murphy, G.A., Marrack, P., Kappler, J.W. 2.3 X-RAY DIFFRACTION 0.275 0.234 False True IGHV7 IGKV8 Kappa None None None None None 5w3o D E 0 B | A | C protein | protein | protein NA | NA | NA viral protein 3 | viral protein 1 | viral protein 2 VIRUS LIKE PARTICLE/IMMUNE SYSTEM 06/08/17 CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:3, empty particle) MUS MUSCULUS; HUMAN RHINOVIRUS 14 mus musculus mus musculus human rhinovirus 14 | human rhinovirus 14 | human rhinovirus 14 Liu, Y., Dong, Y., Rossmann, M.G. 3.01 ELECTRON MICROSCOPY False False IGHV2 IGKV12 Kappa None None None None None 6qee C B 0 A protein abcb1hm-eq MEMBRANE PROTEIN 01/07/19 Nanodisc reconstituted Human-mouse chimeric ABCB1 (ABCB1HM)-EQ mutant in complex with UIC2 Fab and Zosuquidar. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alam, A. 3.9 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7uen H L 0 A carbohydrate GAL BETA-D-GALACTOSE IMMUNE SYSTEM 03/22/22 Genetic and structural basis of the human anti-alpha-galactosyl antibody response Mus musculus mus musculus mus musculus Langley, D.B., Christ, D. 1.55 X-RAY DIFFRACTION 0.175 0.128 False True IGHV6 IGKV1 Kappa None None None None None 3qcu I M 0 I Hapten NKN (2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL TETRADECANOATE IMMUNE SYSTEM 01/17/11 Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (14:0) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fleming, J.K., Wojciak, J.M., Campbell, M.-A., Huxford, T. 1.979 X-RAY DIFFRACTION 0.252 0.222 False True IGHV5 IGKV2D Kappa None None None None None 6iec C D 0 B protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R17 RIFT VALLEY FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.281 0.241 False True IGHV3 IGLV3 Lambda None None None None None 7s1m N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 09/02/21 Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 1) HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cary, B.P., Gellman, S.H. 2.41 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4uih D E 0 A protein dengue virus serotype 2 strain new guinea-c e proteinectodomain 03/30/15 Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human antibody 2D22 Fab at 37 degree C. The Fab molecules were added to the virus before 37 degree C incubation. DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., deSilva, A.M., Harris, E., Crowe, J.E., Lok, S.-M. 20.0 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 7kde H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 10/08/20 BG505 SOSIP.664 in complex with the V3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 3aaz H L 0 IMMUNE SYSTEM 11/28/09 Crystal structure of the humanized recombinant Fab fragment of a murine; antibody HOMO SAPIENS homo sapiens homo sapiens Streltsov, V.A. 2.2 X-RAY DIFFRACTION 0.271 0.209 False True IGHV2 IGKV2 Kappa None None None None None 6x1u A B 0 C peptide NA aclyana-3-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC39-4) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R., Wilson, I.A., Hunter, T. 1.641 X-RAY DIFFRACTION 0.225 0.189 False True IGHV1 IGKV1 Kappa None None None None None 6wha E e 0 B | C protein | protein NA | NA g subunit q (gi2-mini-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/07/20 HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Skiniotis, G., Roth, B., Kim, K., Panova, O. 3.36 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7lcv A B 0 C protein NA factor h binding protein IMMUNE SYSTEM 01/11/21 Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein HOMO SAPIENS; NEISSERIA MENINGITIDIS homo sapiens homo sapiens neisseria meningitidis Beernink, P.T., Sands, N. 1.7 X-RAY DIFFRACTION 0.270 0.240 False True IGHV3 IGKV3 Kappa None None None None None 4bjl NA B 0 IMMUNOGLOBULIN 05/26/95 LOCW, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN DISTILLED WATER HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.4 X-RAY DIFFRACTION unknown unknown False False IGLV1 Lambda None None None None None 5c0n C D 0 B protein fatty acid-binding protein, adipocyte LIPID TRANSPORT 06/12/15 Development of a monoclonal antibody targeting secreted aP2 to treat diabetes and fatty liver disease ORYCTOLAGUS CUNICULUS; MUS MUSCULUS oryctolagus cuniculus oryctolagus cuniculus mus musculus Doyle, C. 3.0 X-RAY DIFFRACTION 0.265 0.186 False True IGHV1 IGKV1 Kappa 4.129999999999999e-06 -7.34515831911734 SPR TBD 7lk4 D C 0 S protein NA bcl-2 homologous antagonist/killer APOPTOSIS 02/01/21 Crystal structure of BAK L100A in complex with activating antibody fragments HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Robin, Y.A., Colman, P.M. 3.1 X-RAY DIFFRACTION 0.262 0.214 False True IGHV5 IGKV16 Kappa None None None None None 6h6z D NA 0 A protein NA capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-62 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 2.085 X-RAY DIFFRACTION 0.217 0.178 False True IGHV1 NA NA None None None None None 7zr7 F G 0 C protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/03/22 OMI-42 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; TEQUATROVIRUS T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, tequatrovirus t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 1g7h B A 0 C protein lysozyme c HYDROLASE INHIBITOR/HYDROLASE 11/10/00 CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3(VLW92A) MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Sundberg, E.J., Urrutia, M., Braden, B.C., Isern, J., Mariuzza, R.A. 1.85 X-RAY DIFFRACTION unknown 0.203 False True IGHV2 IGKV12 Kappa None None None None None 43ca D C 0 C Hapten NPO P-NITROPHENOL IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY WITH BOUND P-NITROPHENOL MUS MUSCULUS mus musculus mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.3 X-RAY DIFFRACTION 0.259 0.206 False True IGHV2 IGKV8 Kappa None None None None None 7jlk A B 0 NA NA NA NA IMMUNE SYSTEM 07/29/20 Crystal structure of glVRC01 Fab in complex with anti-idiotype iv1 scFv MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 1.99 X-RAY DIFFRACTION 0.235 0.179 False True IGHV1 IGKV3 Kappa None None None None None 4krp B NA 0 A protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR HOMO SAPIENS; LAMA GLAMA; MUS MUSCULUS, HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.823 X-RAY DIFFRACTION 0.263 0.215 False True IGHV1 1.66e-07 -9.249427467731744 SPR TBD 6sc5 C NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-Ligand2 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.1 X-RAY DIFFRACTION 0.252 0.219 False True IGHV3 None None None None None 7wwl H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/13/22 S protein of Delta variant in complex with ZWD12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 1r3l B A 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 10/02/03 potassium channel KcsA-Fab complex in Cs+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y., MacKinnon, R. 2.41 X-RAY DIFFRACTION 0.249 0.219 False False IGHV1 IGKV5 Kappa None None None None None 2xqb H L 0 A protein interleukin 15 IMMUNE SYSTEM 09/01/10 Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lowe, D.C., Gerhardt, S., Ward, A., Hargreaves, D., Anderson, M., StGallay, S., Vousden, K., Ferraro, F., Pauptit, R.A., Cochrane, D., Pattison, D.V., Buchanan, C., Popovic, B., Finch, D.K., Wilkinson, T., Sleeman, M., Vaughan, T.J., Cruwys, S., Mallinder, P.R. 2.6 X-RAY DIFFRACTION 0.31811 0.24441 False True IGHV1 IGLV1 Lambda 5.20e-11 -14.02 SPR 21167836 7rth L K 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 6ao0 NA L 0 IMMUNE SYSTEM 08/15/17 CAT192 Fab Insertion Mutant H2/L2 HOMO SAPIENS homo sapiens Lord, D.M., Wei, R.R. 2.35 X-RAY DIFFRACTION 0.261 0.206 False True IGKV1 Kappa None None None None None 5toj D NA 0 A protein fusion glycoprotein f0, fibritin chimera VIRAL PROTEIN/IMMUNE SYSTEM 10/17/16 Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4 HUMAN RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama human respiratory syncytial virus Gilman, M.S.A., Kabeche, S.C., McLellan, J.S. 3.3 X-RAY DIFFRACTION 0.234 0.184 False True IGHV1 2.3e-08 -10.420467653019871 SPR TBD 6udj N O 0 G protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 2.5 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 4hem F NA 0 C protein NA bpp VIRAL PROTEIN 10/04/12 Llama vHH-02 binder of ORF49 (RBP) from lactococcal phage TP901-1 LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 Desmyter, A., Spinelli, S., Farenc, C., Blangy, S., Bebeacua, C., van Sinderen, D., Mahony, J., Cambillau, C. 1.65 X-RAY DIFFRACTION 0.177 0.167 False True IGHV1 NA NA None None None None None 6k4z B b 0 b Hapten NPA 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID IMMUNE SYSTEM 05/27/19 Single-chain Fv antibody of C6 COMPLEXED WITH 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID MUS MUSCULUS mus musculus Nishiguchi, A., Numoto, N., Ito, N., Azuma, T., Oda, M. 1.65 X-RAY DIFFRACTION 0.196 0.167 True True unknown unknown unknown None None None None None 6cnw A NA 0 IMMUNE SYSTEM 03/09/18 STRUCTURE OF HUMANIZED SINGLE DOMAIN ANTIBODY SD84 HYBRID hybrid Luo, J., Obmolova, O. 0.92 X-RAY DIFFRACTION 0.139 0.126 False True IGHV3 None None None None None 5wdu D E 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True unknown unknown unknown None None None None None 6foe A B 0 IMMUNE SYSTEM 02/07/18 BaxB01 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Hollerweger, J., Schinagl, A., Kerschbaumer, R.J., Scheiflinger, F., Thiele, M., Goettig, P., Brandstetter, H. 2.6 X-RAY DIFFRACTION 0.263 0.214 False True IGHV3 IGKV1 Kappa None None None None None 7zr8 H L 0 A protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/03/22 OMI-38 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE RBD (local refinement) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3g6a B A 0 IMMUNE SYSTEM 02/06/09 Crystal structure of anti-IL-13 antibody CNTO607 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.1 X-RAY DIFFRACTION 0.283 0.208 False True IGHV3 IGLV3 Lambda None None None None None 7lf2 F H 0 B protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4nkd A B 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.303 X-RAY DIFFRACTION 0.231 0.195 False True IGHV1 IGKV1 Kappa None None None None None 3ab0 B C 0 A protein bcla protein IMMUNE SYSTEM 11/28/09 Crystal structure of complex of the Bacillus anthracis major spore surface protein BclA with ScFv antibody fragment BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus mus musculus bacillus anthracis Streltsov, V.A. 3.09 X-RAY DIFFRACTION 0.265 0.197 False True IGHV5 IGKV4 Kappa None None None None None 7rd5 B A 0 F protein NA tetraspanin-15 CELL ADHESION 07/09/21 Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Lipper, C.H., Gabriel, K.H., Seegar, T.C.M., Durr, K.L., Tomlinson, M.G., Blacklow, S.C. 3.6 X-RAY DIFFRACTION 0.309 0.271 False True IGHV1 IGKV15 Kappa None None None None None 4k3h NA C 0 D Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 5wt9 H L 0 G protein programmed cell death protein 1 IMMUNE SYSTEM 12/10/16 Complex structure of PD-1 and nivolumab-Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tan, S., Zhang, H., Chai, Y., Song, H., Tong, Z., Wang, Q., Qi, J., Wong, G., Zhu, X., Liu, W.J., Gao, S., Wang, Z., Shi, Y., Yang, F., Gao, G.F., Yan, J. 2.401 X-RAY DIFFRACTION 0.228 0.187 False True IGHV3 IGKV3 Kappa 1.45e-09 -12.058051461423284 SPR TBD 5ja8 D NA 0 C protein toxin higb-2 TOXIN 04/12/16 Crystal structure of the HigB2 toxin in complex with Nb2 LAMA GLAMA; VIBRIO CHOLERAE SEROTYPE O1 (STRAIN ATCC 39315 / EL TOR INABA N16961) lama glama vibrio cholerae serotype o1 (strain atcc 39315/ el tor inaba n16961) Hadzi, S., Loris, R. 2.49 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 None None None None None 7q0h H L 0 E protein NA spike protein s1 VIRAL PROTEIN 10/14/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-50 and Beta-54 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.65 X-RAY DIFFRACTION 0.303 0.255 False True IGHV4 IGKV1 Kappa None None None None None 6ayn B A 0 IMMUNE SYSTEM 09/08/17 Structure of cetuximab with aminoheptanoic acid-linked N-(3-aminopropyl)-L-arginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.222 0.172 False True IGHV2 IGKV5 Kappa 9.199999999999998e-06 -6.870622689559801 Unknown TBD 4nhg M K 0 IMMUNE SYSTEM 11/05/13 Crystal Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West, Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 8.001 X-RAY DIFFRACTION 0.369 0.359 False True unknown IGKV1 Kappa None None None None None 3whe S T 0 D protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 7z1a E NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.59 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 4nco D C 0 A protein bg505 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/24/13 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Lyumkis, D., Ward, A.B., Wilson, I.A. 4.7 X-RAY DIFFRACTION 0.389 0.375 False True IGHV4 IGLV3 Lambda None None None None None 5mv3 F G 0 H peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 4ydl B C 0 A protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 02/22/15 Crystal structure of broadly and potently neutralizing antibody C38-VRC18.02 in complex with HIV-1 clade AE strain 93TH057gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.207 0.174 False True unknown IGKV3 Kappa None None None None None 3nz8 H L 0 IMMUNE SYSTEM 07/16/10 Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 MUS MUSCULUS mus musculus mus musculus Uchtenhagen, H, Friemann, R, Raszewski, G, Spetz, A-L, Nilsson, L, Achour, A 2.7 X-RAY DIFFRACTION 0.273 0.226 False True IGHV1 IGKV1 Kappa None None None None None 3fku T t 0 L | K protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/17/08 Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens influenza a virus | influenza a virus Hwang, W.C., Santelli, E., Stec, B., Wei, G., Cadwell, G., Bankston, L.A., Sui, J., Perez, S., Aird, D., Chen, L.M., Ali, M., Murakami, A., Yammanuru, A., Han, T., Cox, N., Donis, R.O., Liddington, R.C., Marasco, W.A. 3.2 X-RAY DIFFRACTION 0.286 0.232 True True unknown unknown unknown 1.30E-10 -13.48 SPR 25 19234466 5ja8 B NA 0 A protein toxin higb-2 TOXIN 04/12/16 Crystal structure of the HigB2 toxin in complex with Nb2 LAMA GLAMA; VIBRIO CHOLERAE SEROTYPE O1 (STRAIN ATCC 39315 / EL TOR INABA N16961) lama glama vibrio cholerae serotype o1 (strain atcc 39315/ el tor inaba n16961) Hadzi, S., Loris, R. 2.49 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 None None None None None 7ly2 F C 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2M28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6ii9 P Q 0 E protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L3A-44 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.5 X-RAY DIFFRACTION 0.234 0.201 False True IGHV4 IGLV1 Lambda 1.94e-08 -10.521320906302677 SPR TBD 7dhr N NA 0 A | B | G protein | protein | peptide NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 11/17/20 Cryo-EM structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-Gs protein complex. HOMO SAPIENS; BOS TAURUS; LAMA GLAMA lama glama homo sapiens | bos taurus | bos taurus Yang, F., Ling, S.L., Zhou, Y.X., Zhang, Y.N., Lv, P., Liu, S.L., Fang, W., Sun, W.J., Hu, L.Y.A. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7b27 C NA 0 A protein NA unknown VIRAL PROTEIN 11/26/20 RBD domain SARS-CoV2 in complex with neutralizing nanobody NM1230 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS Ostertag, E., Zocher, G., Stehle, T. 2.902 X-RAY DIFFRACTION 0.305 0.266 False False unknown unknown unknown None None None None None 7bh8 E F 0 C | Q protein | peptide NA | NA hla class i histocompatibility antigen, alpha chain e | vl9 leader peptide IMMUNE SYSTEM 01/10/21 3H4-Fab HLA-E-VL9 co-complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Walters, L.C., Rozbesky, D. 1.8 X-RAY DIFFRACTION 0.232 0.195 False True IGHV1 IGKV14 Kappa None None None None None 7mtb H L 2 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6n5d C D 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/21/18 Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Bajic, G., Schmidt, A.G. 3.0 X-RAY DIFFRACTION 0.244 0.217 False True IGHV5 IGLV1 Lambda None None None None None 4dqo H L 0 C protein 1fd6-v1v2 scaffold zm109 hiv-1 strain IMMUNE SYSTEM 02/16/12 Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., McLellan, J.S., Kwong, P.D. 2.438 X-RAY DIFFRACTION 0.230 0.201 False True IGHV3 IGLV2 Lambda None None None None None 5wcc A B 0 IMMUNE SYSTEM 06/29/17 Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 02-1F07 Fab. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Andrews, S.F., Mascola, J.R., McDermott, A.B., Kwong, P.D. 2.461 X-RAY DIFFRACTION 0.240 0.203 False True IGHV3 IGLV2 Lambda None None None None None 7ld1 P O 0 A protein NA spike glycoprotein IMMUNE SYSTEM 01/12/21 Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1047 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 6i04 H L 0 A protein hepatocyte growth factor receptor IMMUNE SYSTEM 10/25/18 Crystal structure of Sema domain of the Met receptor in complex with FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Casaletto, J.B., Geddie, M.L., Abu-Yousif, A.O., Masson, K., Fulgham, A., Boudot, A., Maiwald, T., Kearns, J.D., Kohli, N., Su, S., Razlog, M., Raue, A., Kalra, A., Hakansson, M., Logan, D.T., Welin, M., Chattopadhyay, S., Harms, B.D., Nielsen, U.B., Schoeberl, B., Lugovskoy, A.A., MacBeath, G. 3.1 X-RAY DIFFRACTION 0.261 0.202 False True IGHV4 IGKV1 Kappa None None None None None 2bx5 NA C 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 4wfh G F 0 B protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a Tl+ bound nonconductive conformation MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 3.01 X-RAY DIFFRACTION 0.239 0.203 False True IGHV1 IGKV4 Kappa None None None None None 7lg6 K N 0 F | G protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/21 BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Torres, J.L., Wu, N.R., Ward, A.B. 3.28 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4at6 J K 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 6nfu A B 0 C protein ph-gated potassium channel kcsa membrane protein, metal transport 12/20/18 Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Tilegenova, C., Cortes, D.M., Jahovic, N., Hardy, E., Parameswaran, H., Guan, L., Cuello, L.G. 2.09 X-RAY DIFFRACTION 0.224 0.210 False True IGHV1 IGKV5 Kappa None None None None None 7s8n E e 0 B | C protein | protein NA | NA gs-mini-gq chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/18/21 CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Cao, C., Fay, J.F., Gumpper, R.H., Roth, B.L. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4gw1 D C 0 Immune system 08/31/12 cQFD Meditope MURINAE,HOMO SAPIENS; SYNTHETIC CONSTRUCT murinae,homo sapiens murinae,homo sapiens Donaldson, J.M., Zer, C., Avery, K.N., Bzymek, K.P., Horne, D.A., Williams, J.C. 2.24 X-RAY DIFFRACTION 0.226 0.182 False True IGHV2 IGKV5 Kappa 4.3e-07 -8.685503029519488 Unknown TBD 7lkg D E 0 F peptide NA circumsporozoite protein IMMUNE SYSTEM/ANTIGEN 02/02/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.151 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Xu, K., Kwong, P.D. 2.02 X-RAY DIFFRACTION 0.254 0.213 False True IGHV1 IGKV4 Kappa None None None None None 6qx3 O NA 0 A | B protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit RNA BINDING PROTEIN 03/07/19 Influenza A virus (A/NT/60/1968) polymerase Hetermotrimer in complex with 3'5' cRNA promoter and Nb8205 LAMA GLAMA; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); INFLUENZA A VIRUS (STRAIN A/NORTHERN TERRITORY/60/1968 H3N2); SYNTHETIC CONSTRUCT lama glama influenza a virus (strain a/northernterritory/60/1968 h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Carrique, L., Keown, J.R., Fan, H., Fodor, E., Grimes, J.M. 3.79 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6hkg A B 0 IMMUNE SYSTEM 09/06/18 Structure of FISW84 Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Benton, D.J., Rosenthal, P.B. 1.87 X-RAY DIFFRACTION 0.200 0.183 False True IGHV3 IGKV3 Kappa None None None None None 6ce0 D E 0 B protein envelope glycoprotein gp160 viral protein/immune system 02/09/18 Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Sarkar, A., Wilson, I.A. 4.602 X-RAY DIFFRACTION 0.341 0.313 False True unknown unknown unknown None None None None None 5i1c H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV3-20 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.25 X-RAY DIFFRACTION 0.266 0.220 False True IGHV3 IGKV3 Kappa None None None None None 7v3h K L 0 B protein NA envelope protein e VIRUS/IMMUNE SYSTEM 08/10/21 DENV2_NGC_Fab_C10 28degrees (3Fab:3E) DENGUE VIRUS TYPE 2 (STRAIN THAILAND/NGS-C/1944); HOMO SAPIENS homo sapiens homo sapiens dengue virus type 2 (strain thailand/ngs-c/1944) Shu, B., Zhang, S., Victor, A.K., Ng, T.S., Lok, S.M. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 5tdp D C 0 IMMUNE SYSTEM 09/19/16 Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces HOMO SAPIENS homo sapiens homo sapiens Yin, Y., Carter, P.J. 1.716 X-RAY DIFFRACTION 0.252 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7kde Q R 0 C protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp41 VIRAL PROTEIN/Immune System 10/08/20 BG505 SOSIP.664 in complex with the V3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 4k9e H L 0 C protein mast/stem cell growth factor receptor kit IMMUNE SYSTEM 04/19/13 Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J. 2.7 X-RAY DIFFRACTION 0.282 0.247 False True IGHV3 IGKV1 Kappa 6.4e-12 -15.271102808414621 SPR TBD 4lst H L 0 G protein envelope glycoprotein gp120 of hiv-1 clade c viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 clade C strain ZM176.66 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.55 X-RAY DIFFRACTION 0.239 0.190 False True IGHV1 IGKV3 Kappa None None None None None 6dwa H L 0 H carbohydrate HD4 4-O-[2-acetamido-2-deoxy-beta-D-glucopyranosyl]-1-O-phosphono-D-ribitol IMMUNE SYSTEM 06/26/18 Structure of the 4497 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fong, R., Lupardus, P.J. 1.922 X-RAY DIFFRACTION 0.235 0.207 False True IGHV3 IGKV4 Kappa None None None None None 6hxw H L 0 A protein 5'-nucleotidase IMMUNE SYSTEM 10/18/18 structure of human CD73 in complex with antibody IPH53 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Roussel, A., Amigues, B. 2.78 X-RAY DIFFRACTION 0.232 0.192 False True IGHV1 IGKV1 Kappa None None None None None 4uv4 H L 0 IMMUNE SYSTEM 08/04/14 Crystal structure of anti-FPR Fpro0165 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Douthwaite, J.A., Sridharan, S., Huntington, C., Marwood, R., Hammersley, J., Hakulinen, J.K., Ek, M., Sjogren, T., Rider, D., Privezentzev, C., Seaman, J.C., Cariuk, P., Knights, V., Young, J., Wilkinson, T., Sleeman, M., Finch, D.K., Lowe, D.C., Vaughan, T.J. 3.08 X-RAY DIFFRACTION 0.2804 0.2427 False True IGHV3 IGKV2 Kappa None None None None None 7wpe W NA 0 NA NA NA NA VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with two JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA lama glama Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.69 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7mta H L 3 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7lka A B 0 NA NA NA NA IMMUNE SYSTEM 02/02/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 1.981 X-RAY DIFFRACTION 0.264 0.215 False True IGHV3 IGKV1 Kappa None None None None None 5kaq Q R 0 A protein hemagglutinin IMMUNE SYSTEM 06/01/16 Crystal structure of broadly neutralizing Influenza A antibody 31.a.83 in complex with Hemagglutinin Hong Kong 1968. INFLUENZA A VIRUS (A/HONG KONG/1-4-MA21-1/1968(H3N2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) influenza a virus (a/hong kong/1-4-ma21-1/1968(h3n2)) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 3.514 X-RAY DIFFRACTION 0.313 0.270 False True IGHV3 IGKV3 Kappa None None None None None 2bob A B 0 C protein potassium channel kcsa IMMUNE SYSTEM/TRANSPORT PROTEIN 04/09/05 Potassium channel KcsA-Fab complex in thallium with tetrabutylammonium (TBA) STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Lenaeus, M.J., Vamvouka, M., Focia, P.J., Gross, A. 2.76 X-RAY DIFFRACTION 0.251 0.220 False False IGHV1 IGKV5 Kappa None None None None None 2ai0 I M 0 IMMUNE SYSTEM 07/28/05 Anti-Cocaine Antibody 7.5.21, Crystal Form III MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Ringe, D., Petsko, G.A. 2.2 X-RAY DIFFRACTION 0.279 0.222 False False IGHV5 IGKV1 Kappa None None None None None 7ps3 H L 0 NA NA NA NA VIRAL PROTEIN 09/22/21 Crystal structure of antibody Beta-32 Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Ren, J., Stuart, D.I. 1.7 X-RAY DIFFRACTION 0.188 0.168 False True IGHV1 IGKV1 Kappa None None None None None 1hzh K M 0 IMMUNE SYSTEM 01/24/01 CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN HOMO SAPIENS homo sapiens homo sapiens Saphire, E.O., Burton, D.R., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.273 0.229 False True IGHV1 IGKV3 Kappa None None None None None 3u79 NA F 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 7rco F E 0 A protein NA transforming growth factor beta-2 IMMUNE SYSTEM 07/07/21 Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, J., Lupardus, P.J., Sudhamsu, J. 2.9 X-RAY DIFFRACTION 0.286 0.208 False True IGHV3 IGKV1 Kappa None None None None None 3b2u Q R 0 P protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 3sge H L 0 K peptide r13 peptide IMMUNE SYSTEM 06/14/11 Crystal structure of mAb 17.2 in complex with R13 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Pizarro, J.C., Boulot, G., Hontebeyrie, M., Bentley, G.A. 1.89 X-RAY DIFFRACTION 0.211 0.179 False True IGHV10 IGKV1 Kappa None None None None None 4r4b F E 0 NA NA NA NA IMMUNE SYSTEM 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Acharya, P., Huang, C.-C., Robinson, J., Kwong, P.D. 2.199 X-RAY DIFFRACTION 0.214 0.166 False True IGHV4 IGKV1 Kappa None None None None None 6r8x C B 0 A protein coagulation factor xi BLOOD CLOTTING 04/10/19 COAGULATION FACTOR XI CATALYTIC DOMAIN IN COMPLEX WITH FAB-PORTION OF MAA868 HOMO SAPIENS; UNIDENTIFIED unidentified unidentified homo sapiens Schiering, N., Koch, A. 2.04 X-RAY DIFFRACTION 0.282 0.220 False True IGHV3 IGLV1 Lambda None None None None None 1mak NA A 9 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6pci P S 0 C | F protein | protein NA | NA virion spike glycoprotein | virion spike glycoprotein,virion spike glycoprotein,ebolavirus (makona) gp2 immune system, viral protein 06/17/19 EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus | zaire ebolavirus, ebola virus Ward, A.B., Murin, C.D., Alkutkar, T. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 6jhq D E 0 C protein vp3 VIRUS 02/18/19 The cryo-EM structure of HAV bound to a neutralizing antibody-F4 HUMAN HEPATITIS A VIRUS HU/AUSTRALIA/HM175/1976; MUS MUSCULUS mus musculus mus musculus human hepatitis a virushu/australia/hm175/1976 Cao, L., Liu, P., Yang, P., Gao, Q., Li, H., Sun, Y., Zhu, L., Lin, J., Su, D., Rao, Z., Wang, X. 3.9 ELECTRON MICROSCOPY False False IGHV5 IGKV4 Kappa None None None None None 7l1v H h 0 A | B protein | protein NA | NA engineered guanine nucleotide-binding protein subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/15/20 Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1 HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA mus musculus homo sapiens | homo sapiens Hong, C., Byrne, N.J., Zamlynny, B., Tummala, S., Xiao, L., Shipman, J.M., Partridge, A.T., Minnick, C., Breslin, M.J., Rudd, M.T., Stachel, S.J., Rada, V.L., Kern, J.C., Armacost, K.A., Hollingsworth, S.A., O'Brien, J.A., Hall, D.L., McDonald, T.P., Strickland, C., Brooun, A., Soisson, S.M., Hollenstein, K. 3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5vm4 I NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 7rm0 A B 0 P peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2E10.E9 in complex with P. vivax CSP peptide ANGAGNQPGANGAGNQPG MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 2.71 X-RAY DIFFRACTION 0.246 0.209 False True IGHV9 IGKV8 Kappa None None None None None 1l7i H L 0 IMMUNE SYSTEM 03/15/02 Crystal Structure of the anti-ErbB2 Fab2C4 HOMO SAPIENS homo sapiens homo sapiens Vajdos, F.F., Adams, C.W., Breece, T.N., Presta, L.G., de Vos, A.M., Sidhu, S.S. 1.8 X-RAY DIFFRACTION 0.230 0.197 False True IGHV3 IGKV1 Kappa None None None None None 3eyu H L 0 Q peptide ror2(518-525) peptide IMMUNE SYSTEM 10/21/08 PFA1 Fab fragment complexed with Ror2(518-525) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Gardberg, A.S., Dealwis, C.G. 2.71 X-RAY DIFFRACTION 0.248 0.177 False True IGHV8 IGKV1 Kappa 2.40e-08 -10.21 SPR 20 19385664 6fxn O P 0 L protein tumor necrosis factor ligand superfamily member 13b IMMUNE SYSTEM 03/09/18 Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lammens, A., Maskos, K., Willen, L., Jiang, X., Schneider, P. 2.9 X-RAY DIFFRACTION 0.231 0.191 False True IGHV1 IGLV3 Lambda None None None None None 6ogx C D 0 G protein tumor necrosis factor receptor superfamily member 4 IMMUNE SYSTEM 04/03/19 Ternary complex of OX40R (TNFRSF4) bound to Fab1 and Fab2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M.H., Boenig, G., Harris, S.F. 2.77 X-RAY DIFFRACTION 0.254 0.203 False True IGHV1 IGKV1 Kappa None None None None None 6t3j A B 0 E protein NA tumor necrosis factor receptor superfamily member 10b APOPTOSIS 10/11/19 Dual Epitope Targeting by Anti-DR5 Antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tauchert, M.J., Augustin, M., Krapp, S., Overdijk, M.B., Breij, E.C.W., Hibbert, R.G. 3.05 X-RAY DIFFRACTION 0.282 0.251 False True IGHV14 IGKV3 Kappa None None None None None 4r96 D C 0 Immune System 09/03/14 Structure of a Llama Glama Fab 48A2 against human cMet LLAMA GLAMA lama glama lama glama Klarenbeek, A., El Mazouari, K., Desmyter, A., Blanchetot, C., Hultberg, A., Roovers, R.C., Cambillau, C., Spinelli, S., Del-Favero, J., Verrips, T., de Haard, H., Achour, I. 3.31 X-RAY DIFFRACTION 0.261 0.217 False True IGHV1 IGKV4 Kappa None None None None None 7wpf U V 0 C protein NA spike glycoprotein VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7c61 H L 0 A protein NA 5-hydroxytryptamine receptor 1b,soluble cytochrome b562,5-hydroxytryptamine receptor 1b SIGNALING PROTEIN 05/21/20 Crystal structure of 5-HT1B-BRIL and SRP2070_Fab complex MUS MUSCULUS; HOMO SAPIENS; ESCHERICHIA COLI mus musculus mus musculus homo sapiens, escherichia coli Suzuki, M., Miyagi, H., Asada, H., Yasunaga, M., Suno, C., Takahashi, Y., Saito, J., Iwata, S. 3.0 X-RAY DIFFRACTION 0.290 0.252 False True IGHV1 IGKV5 Kappa None None None None None 6tcn B A 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab - crystal form II HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.3 X-RAY DIFFRACTION 0.226 0.188 False True IGHV3 IGKV1 Kappa None None None None None 5ilt H L 0 IMMUNE SYSTEM 03/04/16 Crystal structure of bovine Fab A01 BOS TAURUS bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.254 0.212 False True IGHV1 IGLV1 Lambda None None None None None 7rta H L 0 N peptide NA neuropeptide y HORMONE/IMMUNE SYSTEM 08/12/21 Crystal structures of human PYY and NPY HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Langley, D.B., Christ, D. 2.6 X-RAY DIFFRACTION 0.270 0.217 False True IGHV1 IGKV1 Kappa None None None None None 7v0v A NA 15 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 3iy4 B A 0 IMMUNE SYSTEM 04/09/09 Variable domains of the computer generated model (WAM) of Fab 15 fitted into the cryoEM reconstruction of the virus-Fab 15 complex MUS MUSCULUS mus musculus mus musculus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Chipman, P.R., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 11.7 ELECTRON MICROSCOPY False False IGHV9 IGKV3 Kappa None None None None None 7ej4 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/01/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-25 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 5ush D E 0 A protein imv membrane protein VIRAL PROTEIN/Immune system 02/13/17 Structure of vaccinia virus D8 protein bound to human Fab vv66 VACCINIA VIRUS; HOMO SAPIENS homo sapiens homo sapiens vaccinia virus Zajonc, D.M. 2.3 X-RAY DIFFRACTION 0.257 0.218 False False IGHV4 IGLV1 Lambda 1.5000000000000002e-09 -12.037965345328766 SPR TBD 7nft D NA 0 B protein NA polymerase basic protein 2 VIRAL PROTEIN 02/07/21 Fujian capbinding domain in complex with Nb8208 INFLUENZA A VIRUS (A/DUCK/FUJIAN/13/2002(H5N1)); HOMO SAPIENS homo sapiens influenza a virus (a/duck/fujian/13/2002(h5n1)) Keown, J.R., Grimes, J.M., Fodor, E. 3.14 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 NA NA None None None None None 6zlr B C 0 A protein NA unknown VIRAL PROTEIN 07/01/20 Soaking competent crystal form of the SARS-CoV-2 Receptor Binding Domain (RBD):CR3022 complex. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS de Nicola, G.F., Nichols, C.E. 3.1 X-RAY DIFFRACTION 0.247 0.218 False False IGHV5 IGKV4 Kappa None None None None None 6ywd A B 0 C protein NA de novo designed protein 4h_01 DE NOVO PROTEIN 04/29/20 De novo designed protein 4H_01 in complex with Mota antibody HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Yang, C., Sesterhenn, F., Pojer, F., Correia, B.E. 3.2 X-RAY DIFFRACTION 0.247 0.206 False True IGHV2 IGKV1 Kappa None None None None None 3cm9 A L 2 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7ce2 Z B 0 A protein NA tetanus toxin HYDROLASE 06/21/20 The Crystal structure of TeNT Hc complexed with neutralizing antibody CLOSTRIDIUM TETANI; HOMO SAPIENS homo sapiens homo sapiens clostridium tetani Wang, X., Wang, Y., Wu, C., Yu, J., Liao, H. 2.01 X-RAY DIFFRACTION 0.218 0.180 False True IGHV4 IGKV3 Kappa None None None None None 7xod NA S 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/01/22 SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA homo sapiens severe acute respiratory syndrome coronavirus2 Xu, Y., Wu, C., Liu, H., Yin, W., Xu, H.E. 3.27 ELECTRON MICROSCOPY NA NA False True NA IGKV1 Kappa None None None None None 5ukr H L 0 G protein chimeric b.yu2 gp120 core derived from hiv-1 env IMMUNE SYSTEM 01/23/17 Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab in complex with a gp120 core MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta human immunodeficiency virus 1 Nicely, N.I. 2.712 X-RAY DIFFRACTION 0.265 0.201 False True IGHV4 IGLV2 Lambda None None None None None 7pi3 K L 0 H protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 3pnw Q P 0 R protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 5hi3 C D 0 A protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 2.15 X-RAY DIFFRACTION 0.231 0.197 False True IGHV3 IGLV6 Lambda None None None None None 6dcw H L 0 T peptide microtubule-associated protein IMMUNE SYSTEM 05/08/18 Crystal structure of human anti-tau antibody CBTAU-27.1 Fab in complex with a human tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens colobus angolensis palliatus Zhu, X., Zhang, H., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.216 0.168 False True IGHV5 IGKV4 Kappa None None None None None 6b9y B A 0 C | E protein | protein NA | NA immunoglobulin g binding protein a | protein l IMMUNE SYSTEM 10/11/17 Trastuzumab Fab v3 in complex with 5-phenyl meditope variant HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens staphylococcus aureus | finegoldia magna Bzymek, K.P., King, J.D., Williams, J.C. 2.14 X-RAY DIFFRACTION 0.218 0.171 False True IGHV3 IGKV1 Kappa None None None None None 2ltq F E 8 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 7czp H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P2B-1A1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 4xp6 H L 0 A protein transporter tranport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Aravind, P., Wang, K., Gouaux, E. 3.1 X-RAY DIFFRACTION 0.259 0.236 False False IGHV5 IGKV4 Kappa None None None None None 5yoy H E 0 C protein tumor necrosis factor IMMUNE SYSTEM 10/31/17 Crystal structure of the human tumor necrosis factor in complex with golimumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N. 2.727 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV3 Kappa 1.8e-11 -14.658430977236662 Unknown TBD 1g9e A NA 0 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 1mlc D C 0 F protein hen egg white lysozyme COMPLEX (ANTIBODY/ANTIGEN) 03/10/95 MONOCLONAL ANTIBODY FAB D44.1 RAISED AGAINST CHICKEN EGG-WHITE LYSOZYME COMPLEXED WITH LYSOZYME MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Braden, B.C., Souchon, H., Eisele, J.-L., Bentley, G.A., Bhat, T.N., Navaza, J., Poljak, R.J. 2.5 X-RAY DIFFRACTION 0.282 unknown False True IGHV1 IGKV5 Kappa 9.10e-08 -9.6 SPR 25 10229844 6ayz R C 0 M protein histone chaperone asf1 IMMUNE SYSTEM 09/08/17 Crystal structure of Asf1-Fab 12E complex HOMO SAPIENS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C) homo sapiens homo sapiens saccharomyces cerevisiae (strain atcc 204508 /s288c) Bailey, L.J., Kossiakoff, A.A. 2.096 X-RAY DIFFRACTION 0.236 0.191 False True IGHV3 IGKV1 Kappa None None None None None 1egj H L 0 A protein cytokine receptor common beta chain precursor IMMUNE SYSTEM 02/15/00 DOMAIN 4 OF THE BETA COMMON CHAIN IN COMPLEX WITH AN ANTIBODY HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rossjohn, J., McKinstry, W.J., Woodcock, J.M., McClure, B.J., Hercus, T.R., Parker, M.W., Lopez, A.F., Bagley, C.J. 2.8 X-RAY DIFFRACTION 0.288 0.228 False False IGHV1 IGKV3 Kappa None None None None None 3uyp A a 0 B protein envelope protein IMMUNE SYSTEM 12/06/11 Crystal structure of the dengue virus serotype 4 envelope protein domain III in complex with the variable domains of Mab 4E11 MUS MUSCULUS; DENGUE VIRUS 4 mus musculus dengue virus 4 Cockburn, J.J.B., Navarro Sanchez, M.E., Fretes, N., Urvoas, A., Staropoli, I., Kikuti, C.M., Coffey, L.L., Arenzana Seisdedos, F., Bedouelle, H., Rey, F.A. 2.0 X-RAY DIFFRACTION 0.201 0.181 True True unknown unknown unknown 4.1e-06 -7.349477781845606 ELISA TBD 1jto B NA 0 M protein NA lysozyme Antibody,Hydrolase 08/21/01 Degenerate interfaces in antigen-antibody complexes CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L. 2.5 X-RAY DIFFRACTION 0.240 0.173 False True IGHV1 NA NA None None None None None 2qr0 L K 0 I protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 6xja H L 0 NA NA NA NA IMMUNE SYSTEM 06/23/20 Streptococcus Pneumoniae IgA1 Protease with IgA1 substrate STREPTOCOCCUS PNEUMONIAE (STRAIN ATCC BAA-255 / R6); HOMO SAPIENS homo sapiens homo sapiens Eisenmesser, E.Z., Zheng, H. 4 ELECTRON MICROSCOPY NA NA False False unknown unknown unknown None None None None None 7jo8 NA A 0 NA NA NA NA IMMUNE SYSTEM 08/06/20 Crystal structure of a Chimeric Antigen Receptor (CAR) scFv domain rearrangement forming a VL-VL dimer SYNTHETIC CONSTRUCT synthetic construct Cheung, J., Hendrickson, W.A., Kochenderfer, J.N., Youkharibache, P. 1.399 X-RAY DIFFRACTION 0.171 0.155 True True NA IGKV3 Kappa None None None None None 6t2j B NA 0 IMMUNE SYSTEM 10/08/19 dAb3 SYNTHETIC CONSTRUCT synthetic construct Tsai, Y.-C.I., House, D., Rittinger, K. 1.7 X-RAY DIFFRACTION 0.208 0.175 False True IGHV3 None None None None None 7lmo NA B 0 B Hapten NYO (5~{R})-3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-7-(1~{H}-imidazol-4-ylcarbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 34 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-7-(1H-imidazole-5-carbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.99 X-RAY DIFFRACTION 0.225 0.176 False True NA IGLV6 Lambda None None None None None 6pzf H L 0 A protein neuraminidase IMMUNE SYSTEM 07/31/19 Crystal structure of human NA-63 Fab in complex with neuraminidase from A/Hunan/02650/2016(H7N9) INFLUENZA A VIRUS (A/HUNAN/02650/2016(H7N9); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/hunan/02650/2016(h7n9) Zhu, X., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV1 Kappa None None None None None 6mph M N 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 4zto H L 0 P peptide epitope of rabbit monoclonal antibody r53 IMMUNE SYSTEM 05/14/15 Fab/epitope complex structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R., Kong, X.-P. 2.3 X-RAY DIFFRACTION 0.223 0.167 False True IGHV1 IGKV1 Kappa None None None None None 4g6j H L 0 A protein interleukin-1 beta IMMUNE SYSTEM 07/19/12 Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab homo sapiens homo sapiens homo sapiens Blech, M., Hoerer, S. 2.03 X-RAY DIFFRACTION 0.252 0.226 False True IGHV3 IGKV1 Kappa 4.0999999999999995e-09 -11.442210050076369 SPR TBD 6xox N NA 0 A | B protein | protein NA | NA alpha subunit of gs with n-terminus swapped with equivalentresidues in gi,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/07/20 cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA lama glama homo sapiens | homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6xxn D NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 5w9k E F 0 D protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.6 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 5ibu H L 0 IMMUNE SYSTEM 02/22/16 6652 Fab (unbound) HOMO SAPIENS homo sapiens homo sapiens Raymond, D.D., Harrison, S.C. 1.71 X-RAY DIFFRACTION 0.245 0.210 False True IGHV5 IGKV3 Kappa None None None None None 5f6h K L 0 IMMUNE SYSTEM 12/06/15 Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.66 X-RAY DIFFRACTION 0.262 0.230 False True IGHV3 IGLV2 Lambda None None None None None 2qad D C 0 A protein envelope glycoprotein gp160 viral protein/immune system 06/14/07 Structure of tyrosine-sulfated 412d antibody complexed with HIV-1 YU2 gp120 and CD4 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.-C., Tang, M., Robinson, J., Wyatt, R., Kwong, P.D. 3.3 X-RAY DIFFRACTION 0.269 0.202 False True IGHV1 IGKV1 Kappa None None None None None 6uup C c 0 NA NA NA NA ANTITUMOR PROTEIN 10/31/19 Structure of anti-hCD33 conditional scFv CAMELIDAE MIXED LIBRARY camelidae mixed library Kimberlin, C.R., Park, S. 2.20002 X-RAY DIFFRACTION 0.237 0.197 True True unknown unknown unknown None None None None None 6ssi J NA 0 E protein cys-loop ligand-gated ion channel TRANSPORT PROTEIN 09/07/19 Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J. 2.59 X-RAY DIFFRACTION 0.246 0.230 False True IGHV1 None None None None None 6y54 M N 0 N unknown OAB unknown IMMUNE SYSTEM 02/24/20 Crystal structure of a Neisseria meningitidis serogroup A capsular oligosaccharide bound to a functional Fab MUS MUSCULUS mus musculus mus musculus mus musculus Dello Iacono, L., Henriques, P., Adamo, R. 2.67 X-RAY DIFFRACTION 0.267 0.210 False True IGHV1 IGKV1 Kappa None None None None None 2mkw NA A 16 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 7luc D E 0 C protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/22/21 Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B RESPIRATORY SYNCYTIAL VIRUS; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus Wrapp, D., McLellan, J.S. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 2kh2 B b 30 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5usl H L 0 X protein imv membrane protein VIRAL PROTEIN/Immune System 02/13/17 Structure of vaccinia virus D8 protein bound to human Fab vv304 VACCINIA VIRUS; HOMO SAPIENS homo sapiens homo sapiens vaccinia virus Zajonc, D.M. 2.9 X-RAY DIFFRACTION 0.297 0.247 False False IGHV3 IGLV3 Lambda 1.6000000000000003e-11 -14.728215503643927 SPR TBD 4n9o B NA 0 A protein major prion protein MEMBRANE PROTEIN/PROTEIN BINDING 10/21/13 Probing the N-terminal beta-sheet conversion in the crystal structure of the human prion protein bound to a Nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Abskharon, R.N.N., Giachin, G., Wohlkonig, A., Soror, S.H., Pardon, E., Legname, G., Steyaert, J. 1.5 X-RAY DIFFRACTION 0.184 0.150 False True IGHV3 None None None None None 7jgj H L 0 A protein NA immunoglobulin a1 protease IMMUNE SYSTEM 07/19/20 IgA1 Protease in complex with neutralizing mAb STREPTOCOCCUS PNEUMONIAE; MUS MUSCULUS mus musculus mus musculus streptococcus pneumoniae Eisenmesser, E.Z., Zheng, H. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 6xxn A NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 7s6j F G 0 E protein NA spike glycoprotein VIRAL PROTEIN/Immune System 09/14/21 J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6e5p H L 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7m6e H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, BG10-19 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 7sfw S T 0 K protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 (focus refine of the asymmetric unit) VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 7wi0 C E 0 A protein NA spike protein s1 VIRAL PROTEIN 01/01/22 SARS-CoV-2 Omicron variant spike in complex with three human neutralizing antibodies Homo sapiens homo sapiens homo sapiens homo sapiens Zheng, Q., Li, S., Sun, H., Zheng, Z., Wang, S. 3.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7kfg A B 0 NA NA NA NA IMMUNE SYSTEM 10/13/20 Antibody Fab BDBV-289 HOMO SAPIENS homo sapiens homo sapiens Murin, C.D., Bruhn, J.F., Ward, A.B. 3.002 X-RAY DIFFRACTION 0.268 0.221 False True IGHV1 IGLV3 Lambda None None None None None 5hi5 C D 0 A protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 1.8 X-RAY DIFFRACTION 0.219 0.201 False True IGHV3 IGLV6 Lambda None None None None None 1t03 H L 0 B protein pol polyprotein Transferase/Antibody/DNA 04/07/04 HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P) HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Tuske, S., Sarafianos, S.G., Ding, J., Arnold, E. 3.1 X-RAY DIFFRACTION 0.295 0.256 False False IGHV8 IGKV10 Kappa None None None None None 2mmx NA A 17 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 2fjh B A 0 W protein vascular endothelial growth factor a HORMONE/GROWTH FACTOR/IMMUNE SYSTEM 01/02/06 Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.1 X-RAY DIFFRACTION 0.239 0.198 False True IGHV3 IGKV1 Kappa 3.80e-09 -11.94 SPR 37 16373345 6qd6 I NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 7ly2 N O 0 J protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2M28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 4am0 H L 0 R protein envelope protein, VIRAL PROTEIN 03/06/12 Structure of Dengue virus strain 4 DIII in complex with Fab 2H12 DENGUE VIRUS; HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus dengue virus Midgley, C.M., Flanagan, A., Mongkolsapaya, J., Grimes, J.M., Screaton, G.R. 3.02 X-RAY DIFFRACTION 0.2522 0.1960 False False IGHV1 IGKV6 Kappa 4.2e-10 -12.792176733448072 ELISA TBD 5vl2 G NA 0 G Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 7kpj A B 0 E protein NA gram_pos_anchoring domain-containing protein IMMUNE SYSTEM 11/11/20 Crystal structure of Ruminococcus gnavus immunoglobulin binding protein in complex with 338E6 Fab MUS MUSCULUS; RUMINOCOCCUS GNAVUS mus musculus mus musculus ruminococcus gnavus Borowska, M.T., Adams, E.J. 2.1 X-RAY DIFFRACTION 0.266 0.229 False True IGHV5 IGKV6 Kappa None None None None None 6s8d P O 0 C protein envelope glycoprotein VIRAL PROTEIN 07/09/19 Structure of ZEBOV GP in complex with 1T0227 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 3.49 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6lgw C D 0 F protein glycoprotein,glycoprotein,glycoprotein VIRAL PROTEIN 12/06/19 Structure of Rabies virus glycoprotein in complex with neutralizing antibody 523-11 at acidic pH MUS MUSCULUS; RABIES LYSSAVIRUS mus musculus mus musculus rabies lyssavirus Yang, F.L., Lin, S., Ye, F., Yang, J., Qi, J.X., Chen, Z.J., Lin, X., Wang, J.C., Yue, D., Cheng, Y.W., Chen, Z.M., Chen, H., You, Y., Zhang, Z.L., Yang, Y., Yang, M., Sun, H.L., Li, Y.H., Cao, Y., Yang, S.Y., Wei, Y.Q., Gao, G.F., Lu, G.W. 2.9037 X-RAY DIFFRACTION 0.268 0.218 False True IGHV1 IGKV5 Kappa None None None None None 4zso D C 0 F protein natural cytotoxicity triggering receptor 3 ligand 1 IMMUNE SYSTEM 05/13/15 Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xu, X., Li, Y., Mariuzza, R.A. 2.5 X-RAY DIFFRACTION 0.257 0.226 False True IGHV1 IGKV4 Kappa None None None None None 6eyn H L 0 IMMUNE SYSTEM 11/13/17 Structure of the 8D6 (anti-IgE) Fab HOMO SAPIENS homo sapiens homo sapiens Chen, J.B., Ramadani, F., Pang, M.O.Y., Beavil, R.L., Holdom, M.D., Mitropoulou, A.N., Beavil, A.J., Gould, H.J., Chang, T.W., Sutton, B.J., McDonnell, J.M., Davies, A.M. 2.4 X-RAY DIFFRACTION 0.212 0.181 False True IGHV1 IGKV3 Kappa None None None None None 3jbd 7 NA 0 3 protein NA capsid protein vp3 VIRUS/IMMUNE SYSTEM 08/26/15 Complex of poliovirus with VHH PVSP6A CAMELUS DROMEDARIUS; HUMAN POLIOVIRUS 1 MAHONEY camelus dromedarius human poliovirus 1 mahoney Strauss, M., Schotte, L., Thys, B., Filman, D.J., Hogle, J.M. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6z1z B NA 0 NA NA NA NA IMMUNE SYSTEM 05/14/20 Structure of the anti-CD9 nanobody 4C8 LAMA GLAMA lama glama Neviani, N., Oosterheert, W., Pearce, N.M., Lutz, M., Kroon-Batenburg, L.M.J., Gros, P. 1.7 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 NA NA None None None None None 5x2o H L 0 A protein NA taste receptor, type 1, member 2a SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-arginine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.6 X-RAY DIFFRACTION 0.272 0.185 False True IGHV1 IGKV3 Kappa None None None None None 1h8o B b 0 ANTIBODY 02/14/01 Selection, characterization and X-ray Structure of anti-ampicillin single chain Fv fragments from phage-displayed murine antibody libraries MUS MUSCULUS mus musculus Burmester, J., Spinelli, S., Pugliese, L., Krebber, A., Honegger, A., Jung, S., Schimmele, B., Cambillau, C., Pluckthun, A. 2.75 X-RAY DIFFRACTION 0.258 0.178 True True unknown unknown unknown None None None None None 7kej I L 0 C protein NA virion spike glycoprotein VIRAL PROTEIN/Immune System 10/11/20 BDBV-289 bound to EBOV GPdMuc Makona EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 3qxu B NA 0 IMMUNE SYSTEM 03/02/11 Free Structure of an Anti-Methotrexate CDR1-3 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.8 X-RAY DIFFRACTION 0.214 0.182 False True IGHV1 None None None None None 7a3p I M 0 B protein NA envelope protein e VIRAL PROTEIN 08/18/20 Crystal structure of dengue 3 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10 DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 3.19 X-RAY DIFFRACTION 0.284 0.241 False True IGHV1 IGLV2 Lambda None None None None None 3jab H L 0 C protein phosphodiesterase 5/6 chimera catalytic domain HYDROLASE/IMMUNE SYSTEM 05/26/15 Domain organization and conformational plasticity of the G protein effector, PDE6 BOS TAURUS; MUS MUSCULUS mus musculus mus musculus bos taurus Zhang, Z., He, F., Constantine, R., Baker, M.L., Baehr, W., Schmid, M.F., Wensel, T.G., Agosto, M.A. 11 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa None None None None None 4y5v A B 0 C protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 2.604 X-RAY DIFFRACTION 0.229 0.187 False True IGHV3 IGLV2 Lambda None None None None None 3cdc NA A 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 7ly2 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2M28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7kf9 I L 0 C protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-296 and EBOV-515 HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 6osy F E 0 B protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 5w08 O P 0 E protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 05/30/17 A/Texas/50/2012(H3N2) Influenza hemagglutinin in complex with K03.12 Fab INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 2.6 X-RAY DIFFRACTION 0.262 0.240 False True IGHV1 IGLV2 Lambda 4e-08 -10.092595930642474 SPR TBD 7eam H L 0 A protein NA spike protein s1 VIRAL PROTEIN, IMMUNE SYSTEM 03/07/21 immune complex of SARS-CoV-2 RBD and cross-neutralizing antibody 7D6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Li, T.T., Gu, Y., Li, S.W. 1.4 X-RAY DIFFRACTION 0.182 0.172 False False IGHV14 IGKV12 Kappa None None None None None 5e5m F NA 0 E protein cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 10/08/15 Crystal structure of mouse CTLA-4 in complex with nanobody MUS MUSCULUS mus musculus mus musculus Fedorov, A.A., Fedorov, E.V., Samanta, D., Bonanno, J.B., Almo, S.C. 2.182 X-RAY DIFFRACTION 0.247 0.193 False True IGHV1 None None None None None 5utz F G 0 E protein interleukin-2 CYTOKINE/IMMUNE SYSTEM 02/15/17 Human IL-2/Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Jude, K.M., Garcia, K.C. 2.747 X-RAY DIFFRACTION 0.248 0.193 False True IGHV4 IGLV6 Lambda 1.879e-09 -11.904493814008964 SPR TBD 7ej5 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 04/01/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7oan H NA 0 C protein NA spike glycoprotein ANTIVIRAL PROTEIN 04/19/21 Nanobody C5 bound to Spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Naismith, J.H., Weckener, M. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2qtj D N 6 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6psc A a 0 IMMUNE SYSTEM 06/17/20 Antibody scFv-M204 trimeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 3.6 X-RAY DIFFRACTION 0.282 0.252 True True unknown unknown unknown None None None None None 7faf H L 0 C protein NA p36-5d2 light chain VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 S protein of SARS-CoV-2 in complex bound with P36-5D2 (state1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, L., Wang, X., Zhang, S., Shan, S. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 1vhp A NA 17 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6wik D C 0 A protein NA solute carrier family 40 protein MEMBRANE PROTEIN 04/10/20 Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin CARLITO SYRICHTA; MUS MUSCULUS mus musculus mus musculus carlito syrichta Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M. 3.4 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 3pjs D C 0 K | L protein | protein NA | NA voltage-gated potassium channel | voltage-gated potassium channel TRANSPORT PROTEIN 11/10/10 Mechanism of Activation Gating in the Full-Length KcsA K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans | streptomyces lividans Uysal, S., Cuello, L.G., Kossiakoff, A., Perozo, E. 3.8 X-RAY DIFFRACTION 0.332 0.281 False True IGHV3 IGKV1 Kappa None None None None None 5uhy H G 0 A protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/12/17 A Human Antibody Against Zika Virus Crosslinks the E Protein to Prevent Infection HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Hasan, S.S., Miller, A., Sapparapu, G., Fernandez, E., Klose, T., Long, F., Fokine, A., Porta, J.C., Jiang, W., Diamond, M.S., Crowe Jr., J.E., Kuhn, R.J., Rossmann, M.G. 6.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 5yax A a 0 IMMUNE SYSTEM 09/02/17 Crystal structure of a human neutralizing antibody bound to a HBV preS1 peptide HOMO SAPIENS; HEPATITIS B VIRUS homo sapiens Liu, X., Zheng, S., Ye, K., Sui, J. 2.5 X-RAY DIFFRACTION 0.288 0.242 True True unknown unknown unknown None None None None None 5cck H L 0 IMMUNE SYSTEM 07/02/15 Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab HOMO SAPIENS homo sapiens homo sapiens Lee, J.H., Ward, A.B., Wilson, I.A. 1.95 X-RAY DIFFRACTION 0.207 0.156 False True IGHV1 IGLV2 Lambda None None None None None 5vn8 F J 0 D protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/28/17 Cryo-EM model of B41 SOSIP.664 in complex with fragment antigen binding variable domain of b12 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Pallesen, J., Ward, A.B., Cottrell, C.A. 3.6 ELECTRON MICROSCOPY / HOMOLOGY MODEL False True IGHV1 IGKV3 Kappa None None None None None 7w9f A B 0 E protein NA spike protein s1 VIRAL PROTEIN 12/09/21 SARS-CoV-2 Delta S-RBD-8D3 MUS MUSCULUS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7kza H L 0 NA NA NA NA IMMUNE SYSTEM 12/10/20 Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies HOMO SAPIENS homo sapiens homo sapiens Langley, D.B., Christ, D. 1.69 X-RAY DIFFRACTION 0.192 0.166 False True IGHV5 IGKV1 Kappa None None None None None 7n07 H L 0 NA NA NA NA IMMUNE SYSTEM 05/25/21 Crystal structure of the apo 3D6 antibody fragment HOMO SAPIENS homo sapiens homo sapiens Cook, J.D., Lee, J.E. 2.4 X-RAY DIFFRACTION 0.239 0.195 False True IGHV3 IGKV1 Kappa None None None None None 6ewb J K 0 D protein vp1 VIRAL PROTEIN 11/03/17 Crystal structure of GII.4 UNSW 2012 P domain in complex with Fab 10E9 NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; MUS MUSCULUS mus musculus mus musculus norovirus hu/gii.4/sydney/nsw0514/2012/au Koromyslova, A.D., Hansman, G.S. 2.78 X-RAY DIFFRACTION 0.222 0.186 False True IGHV1 IGKV4 Kappa None None None None None 6p91 H L 0 a | A protein | protein NA | NA unknown | pre-glycoprotein polyprotein gp complex,lassa virusglycoprotein, gp2 subunit viral protein/immune system 06/09/19 Structure of Lassa virus glycoprotein bound to Fab 18.5C LASSA MAMMARENAVIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa mammarenavirus | lassa mammarenavirus Saphire, E.O., Hastie, K.M. 4.0 X-RAY DIFFRACTION 0.254 0.204 False True IGHV3 IGKV3 Kappa None None None None None 6cue 7 8 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6db9 H L 0 R nucleic-acid rna (60-mer) RNA/Immune System 05/02/18 Structural basis for promiscuous binding and activation of fluorogenic dyes by DIR2s RNA aptamer SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct synthetic construct synthetic construct Shao, Y., Shelke, S.A., Laski, A., Piccirilli, J.A. 2.025 X-RAY DIFFRACTION 0.257 0.230 False True IGHV3 IGKV1 Kappa 7.08e-07 -8.390055778266369 Unknown TBD 7bxa H L 0 P protein programmed cell death protein 1 IMMUNE SYSTEM 06/10/20 Crystal structure of PD-1 in complex with tislelizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, S.H., Lim, H., Lee, H.T., Kim, Y.J., Park, E.B. 3.32 X-RAY DIFFRACTION 0.299 0.243 False True IGHV4 IGKV4 Kappa None None None None None 1frg H L 0 P peptide influenza hemagglutinin ha1 (strain x47)(residues 101 - 108) VIRAL PROTEIN/IMMUNE SYSTEM 01/17/94 CRYSTAL STRUCTURE, SEQUENCE, AND EPITOPE MAPPING OF A PEPTIDE COMPLEX OF AN ANTI-INFLUENZA HA PEPTIDE ANTIBODY FAB 26(SLASH)9: FINE-TUNING ANTIBODY SPECIFICITY MUS MUSCULUS mus musculus Churchill, M.E.A., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.190 False True IGHV5 IGKV8 Kappa None None None None None 1t04 B A 0 IMMUNE SYSTEM 04/07/04 Three dimensional structure of a humanized anti-IFN-Gamma Fab in C2 space group HOMO SAPIENS homo sapiens homo sapiens Bourne, P.C., Terzyan, S.S., Cloud, G., Landolfi, N.F., Vasquez, M., Edmundson, A.B. 3.0 X-RAY DIFFRACTION 0.293 0.217 False True IGHV1 IGKV1 Kappa None None None None None 4nyl H L 0 IMMUNE SYSTEM 12/10/13 Crystal structure of adalimumab FAB fragment HOMO SAPIENS homo sapiens homo sapiens Fan, L.J., Lv, L.L., Zhang, Q.J., Chen, C.L. 2.8 X-RAY DIFFRACTION 0.358 0.275 False True IGHV3 IGKV1 Kappa None None None None None 3lrs C D 0 D carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/11/10 Structure of PG16, an antibody with broad and potent neutralization of HIV-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pancera, M., Kwong, P.D. 2.37 X-RAY DIFFRACTION 0.260 0.211 False True IGHV3 IGLV2 Lambda None None None None None 6lhq H L 0 A | C | B protein | protein | protein NA | NA | NA vp1 protein | vp3 protein | vp2 protein VIRUS 12/09/19 The cryo-EM structure of coxsackievirus A16 mature virion in complex with Fab NA9D7 COXSACKIEVIRUS A16; MUS MUSCULUS mus musculus mus musculus coxsackievirus a16 | coxsackievirus a16 | coxsackievirus a16 He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W. 3.06 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 4dke I M 0 B protein interleukin-34 CYTOKINE/IMMUNE SYSTEM 02/03/12 Crystal Structure of Human Interleukin-34 Bound to FAb1.1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ma, X., Chen, Y., Stawicki, S., Wu, Y., Bazan, J.F., Starovasnik, M.A. 3.0 X-RAY DIFFRACTION 0.265 0.231 False True IGHV3 IGKV1 Kappa 1.2e-10 -13.534418347189932 SPR TBD 4ybl B C 0 A protein stabilized inner domain of clade a/e gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/15 Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 in complex with the ADCC mediating ANTI-HIV-1 antibody A32 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 3.1 X-RAY DIFFRACTION 0.289 0.232 False True IGHV4 IGLV2 Lambda 1.7000000000000003e-10 -13.328052315201264 SPR TBD 6h3u I M 0 A protein envelopment polyprotein VIRAL PROTEIN 07/19/18 Schmallenberg Virus Glycoprotein Gc Head Domain in Complex with scFv 4B6 MUS MUSCULUS; BOVINE SCHMALLENBERG VIRUS mus musculus mus musculus bovine schmallenberg virus Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A. 3.168 X-RAY DIFFRACTION 0.228 0.200 False True IGHV3 IGKV10 Kappa None None None None None 6yax I M 0 B protein NA unknown IMMUNE SYSTEM 03/14/20 Crystal structure of CD32b (Fc Gamma Receptor IIb) in complex with Human IgG1 Fab fragment (5C05) HOMO SAPIENS Fisher, H., Tews, I., Orr, C. 2.8 X-RAY DIFFRACTION 0.264 0.230 False False IGHV3 IGLV1 Lambda None None None None None 3ld8 C B 0 A protein bifunctional arginine demethylase and lysyl-hydroxylasejmjd6 IMMUNE SYSTEM 01/12/10 Structure of JMJD6 and Fab Fragments HOMO SAPIENS; CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius homo sapiens Hong, X., Zang, J., White, J., Kappler, J.W., Wang, C., Zhang, G. 2.7 X-RAY DIFFRACTION 0.260 0.233 False True IGHV3 IGKV8 Kappa None None None None None 4qhm G H 0 IMMUNE SYSTEM 05/28/14 I3.1 (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.23 X-RAY DIFFRACTION 0.251 0.224 False True IGHV4 IGLV3 Lambda None None None None None 7tht H L 0 C protein NA dh1042 light chain VIRAL PROTEIN/IMMUNE SYSTEM 01/12/22 CryoEM structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1042 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., May, A., Acharya, P. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 4xh2 G I 0 g peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD4 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.0 X-RAY DIFFRACTION 0.258 0.224 False True IGHV3 IGKV1 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 3utz C D 0 IMMUNE SYSTEM 11/27/11 Endogenous-like inhibitory antibodies targeting activated metalloproteinase motifs show therapeutic potential MUS MUSCULUS Sela-Passwell, N., Kikkeri, R, Dym, O., Rozenberg, H, Margalit, R, Arad-Yellin, R., Eisenstein, M., Brenner, O., Shoham, T., Danon, T., Shanzer, A., Sagi, I., Israel Structural Proteomics Center (ISPC) 2.18 X-RAY DIFFRACTION 0.288 0.228 False True IGHV5 IGKV1 Kappa None None None None None 7a0w C D 0 A protein NA na(+)/h(+) antiporter nhaa MEMBRANE PROTEIN 08/11/20 Structure of dimeric sodium proton antiporter NhaA, at pH 8.5, crystallized with chimeric Fab antibodies SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM STR. LT2; GALLUS GALLUS; HOMO SAPIENS gallus gallus, homo sapiens gallus gallus, homo sapiens salmonella enterica subsp. enterica serovartyphimurium str. lt2 Fippel, A., Gross, N.M., Mir, S.H., Wirth, C., Hunte, C. 2.04 X-RAY DIFFRACTION 0.235 0.198 False True unknown unknown unknown None None None None None 7p00 H h 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/29/21 Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens | homo sapiens Thom, C., Ehrenmann, J., Vacca, S., Waltenspuhl, Y., Schoppe, J., Medalia, O., Pluckthun, A. 2.71 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ls9 E G 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/17/21 Cryo-EM structure of neutralizing antibody 1-57 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6kz0 K L 0 J protein genome polyprotein VIRAL PROTEIN 05/27/20 HRV14 3C in complex with single chain antibody GGVV HUMAN RHINOVIRUS 14; HOMO SAPIENS homo sapiens homo sapiens human rhinovirus 14 Meng, B., Yang, B., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.223 0.185 False True IGHV1 IGKV1 Kappa None None None None None 6dc5 E F 0 D protein rsv fusion glycoprotein IMMUNE SYSTEM 05/04/18 RSV prefusion F in complex with AM22 Fab HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Jones, H.G., McLellan, J.S. 3.5 X-RAY DIFFRACTION 0.280 0.217 False True IGHV1 IGKV3 Kappa None None None None None 6wtu H I 0 G protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 273264 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.55 X-RAY DIFFRACTION 0.255 0.208 False True IGHV3 IGLV3 Lambda None None None None None 7ws0 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5bop A NA 0 B protein octarellin v.1 DE NOVO PROTEIN 05/27/15 Crystal structure of the artificial nanobody octarellinV.1 complex SYNTHETIC CONSTRUCT; LAMA GLAMA lama glama synthetic construct Figueroa, M., Sleutel, M., Pardon, E., Steyaert, J., Martial, J.A., van de Weerdt, C. 1.95 X-RAY DIFFRACTION 0.229 0.192 False True IGHV1 None None None None None 6dwc H L 0 IMMUNE SYSTEM 06/26/18 Structure of the apo 4497 antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.27 X-RAY DIFFRACTION 0.217 0.184 False True IGHV3 IGKV4 Kappa None None None None None 6grz NA A 0 IMMUNE SYSTEM 06/13/18 Crystal structure of the light chain dimer mH6 HOMO SAPIENS homo sapiens Maritan, M., Ricagno, S., Ambrosetti, A., Oberti, L. 2.1 X-RAY DIFFRACTION 0.238 0.206 False True IGLV1 Lambda None None None None None 7lf1 F H 0 C protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6pds H L 0 G peptide NA hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 06/19/19 Vaccine-elicited NHP FP-targeting antibody 0PV-a.04 in complex with HIV fusion peptide (residue 512-519) MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 1.893 X-RAY DIFFRACTION 0.220 0.193 False True IGHV4 IGKV1 Kappa None None None None None 1ub6 A B 0 IMMUNE SYSTEM 03/30/03 Crystal structure of Antibody 19G2 with sera ligand MUS MUSCULUS mus musculus mus musculus Beuscher, A.B., Wirsching, P., Lerner, R.A., Janda, K., Stevens, R.C. 2.12 X-RAY DIFFRACTION 0.292 0.264 False True IGHV5 IGKV2 Kappa None None None None None 3zhk B NA 0 12/22/12 The crystal structure of single domain antibody 2x1 scaffold ESCHERICHIA COLI Song, H.-N., Woo, E.-J., Lim, H.-K. 1.962 X-RAY DIFFRACTION 0.2977 0.2528 False True IGHV3 None None None None None 3mxw H L 0 A protein sonic hedgehog protein SIGNALING PROTEIN 05/07/10 Crystal structure Sonic hedgehog bound to the 5E1 fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G., Maun, H.R. 1.83 X-RAY DIFFRACTION 0.218 0.176 False True IGHV1 IGKV6 Kappa 7.00e-10 -12.7 ITC 30 20504762 7ept N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 04/27/21 Structural basis for the tethered peptide activation of adhesion GPCRs HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ping, Y.-Q., Xiao, P., Yang, F., Zhao, R.-J., Guo, S.-C., Yan, X., Wu, X., Liebscher, I., Xu, H.E., Sun, J.-P. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2ck0 H L 0 P peptide protein (11-mer; cyclic peptide) IMMUNOGLOBULIN 06/13/99 ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, COMPLEX WITH A SYNTHETIC CYCLIC PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Pan, Y.H., Amzel, L.M. 2.2 X-RAY DIFFRACTION 0.296 0.200 False False IGHV10 IGKV8 Kappa None None None None None 5euk B A 0 IMMUNE SYSTEM 11/18/15 Cetuximab Fab in complex with F3H meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.5 X-RAY DIFFRACTION 0.234 0.171 False True IGHV2 IGKV5 Kappa None None None None None 5w6d D E 0 B protein bg505-sosip.v4.1-gt1-n137a gp41 VIRAL PROTEIN/Immune System 06/16/17 Crystal structure of BG505-SOSIP.v4.1-GT1-N137A in complex with Fabs 35022 and 9H/109L HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Garces, F., Stanfield, R.L., Wilson, I.A. 3.202 X-RAY DIFFRACTION 0.267 0.242 False True unknown unknown unknown None None None None None 7tcc F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1zvy A NA 0 B protein lysozyme c HYDROLASE/IMMUNE SYSTEM 06/03/05 Crystal structure of the VHH D3-L11 in complex with hen egg white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., Wyns, L. 1.63 X-RAY DIFFRACTION 0.229 0.209 False True IGHV1 1.00e-10 -13.63 SPR 16537393 1kxq F NA 0 C protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 1.6 X-RAY DIFFRACTION 0.219 0.197 False True IGHV1 3.50e-09 -11.53 SPR 11960990 5vlv A NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T9 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.35 X-RAY DIFFRACTION 0.189 0.162 False True IGHV1 None None None None None 1p4b H L 0 P peptide gcn4(7p-14p) peptide IMMUNE SYSTEM 04/22/03 Three-Dimensional Structure Of a Single Chain Fv Fragment Complexed With The peptide GCN4(7P-14P). MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Zahnd, C., Spinelli, S., Luginbuhl, B., Jermutus, L., Amstutz, P., Cambillau, C., Pluckthun, A. 2.35 X-RAY DIFFRACTION 0.300 0.219 True True IGHV2 IGLV1 Lambda 4.00E-11 -13.94 SPR 20 14754898 2a9m H L 0 IMMUNE SYSTEM 07/12/05 Structural Analysis of a Tight-binding Fluorescein-scFv; apo form HOMO SAPIENS homo sapiens homo sapiens Cambillau, C., Spinelli, S., Honegger, A., Pluckthun, A. 2.1 X-RAY DIFFRACTION 0.263 0.210 True True IGHV3 IGLV1 Lambda None None None None None 1h3p H L 0 IMMUNOGLOBULIN 09/12/02 STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS MUS MUSCULUS mus musculus mus musculus Pizarro, J.C., Vulliez-Le-normand, B., Riottot, M.M., Budkowska, A., Bentley, G.A. 2.6 X-RAY DIFFRACTION 0.2908 0.2126 False False IGHV5 IGKV8 Kappa None None None None None 4m48 H L 0 A protein transporter TRANSPORT PROTEIN 08/06/13 X-ray structure of dopamine transporter elucidates antidepressant mechanism DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Gouaux, E., Penmatsa, A., Wang, K. 2.955 X-RAY DIFFRACTION 0.256 0.221 False False IGHV5 IGKV4 Kappa None None None None None 3qpq D C 0 IMMUNE SYSTEM 02/14/11 Crystal structure of ANTI-TLR3 antibody C1068 FAB HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Luo, J., Obmolova, G., Teplyakov, A., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.256 0.201 False True IGHV1 IGKV12 Kappa None None None None None 6ssi I NA 0 D protein cys-loop ligand-gated ion channel TRANSPORT PROTEIN 09/07/19 Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J. 2.59 X-RAY DIFFRACTION 0.246 0.230 False True IGHV1 None None None None None 7oao F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 04/19/21 Nanobody C5 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 1.5 X-RAY DIFFRACTION 0.186 0.152 False False IGHV1 NA NA None None None None None 5ea0 H L 0 P peptide complement factor h-related protein 2 IMMUNE SYSTEM 10/15/15 Structure of the antibody 7968 with human complement factor H-derived peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Bushey, R.T., Moody, M.A., Nicely, N.I., Alam, S.M., Haynes, B.F., Winkler, M.T., Gottlin, E.B., Campa, M.J., Liao, H.-X., Patz Jr., E.F. 2.0 X-RAY DIFFRACTION 0.275 0.196 False True IGHV3 IGKV4 Kappa None None None None None 2xv6 D NA 0 C protein capsid protein p24 VIRAL PROTEIN/IMMUNE SYSTEM 10/22/10 Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH. HUMAN IMMUNODEFICIENCY VIRUS 1; VICUGNA PACOS vicugna pacos human immunodeficiency virus 1 Igonet, S., Vaney, M.-C., Bartonova, V., Helma, J., Rothbauer, U., Leonhardt, H., Stura, E., Krausslich, H.-G., Rey, F.A. 1.89 X-RAY DIFFRACTION 0.1952 0.1748 False True IGHV1 None None None None None 4f15 E F 0 D protein hemagglutinin IMMUNE SYSTEM 05/06/12 Molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Lee, J.H., Park, Y.H., Khan, T.G., Lee, J.Y., Kang, S.H., Alam, I. 2.81 X-RAY DIFFRACTION 0.289 0.233 False False IGHV3 IGKV7 Kappa None None None None None 7m1c H L 0 NA NA NA NA IMMUNE SYSTEM 03/12/21 Crystal structure of the HCMV pentamer-specific antibody 1-32 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.297 0.268 False True IGHV3 IGKV1 Kappa None None None None None 5ywo N M 0 C protein NA jev e protein VIRUS 11/29/17 Structure of JEV-2F2 Fab complex JAPANESE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus japanese encephalitis virus Qiu, X., Lei, Y.F., Yang, P., Gao, Q., Wang, N., Cao, L., Yuan, S., Wang, X., Xu, Z.K., Rao, Z. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV3 Kappa None None None None None 5bk2 C D 0 B protein maltose-binding periplasmic protein SUGAR BINDING PROTEIN 09/12/17 Crystal structure of maltose binding protein in complex with a peristeric synthetic antibody ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Mukherjee, S., Kossiakoff, A.A. 2.6 X-RAY DIFFRACTION 0.259 0.212 False True IGHV3 IGKV1 Kappa None None None None None 4qww F E 0 A protein acetylcholinesterase HYDROLASE/IMMUNE SYSTEM 07/17/14 Crystal structure of the Fab410-BfAChE complex BUNGARUS FASCIATUS; MUS MUSCULUS mus musculus mus musculus bungarus fasciatus Bourne, Y., Renault, L., Marchot, P. 2.7 X-RAY DIFFRACTION 0.239 0.199 False False IGHV10 IGKV4 Kappa None None None None None 2itc A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 10/19/06 Potassium Channel KcsA-Fab complex in Sodium Chloride STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Lockless, S.W., Zhou, M., MacKinnon, R. 3.2 X-RAY DIFFRACTION 0.265 0.246 False False IGHV1 IGKV5 Kappa None None None None None 6x87 M N 0 X protein NA circumsporozoite protein IMMUNE SYSTEM 06/01/20 CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Kucharska, I., Thai, E., Rubinstein, J., Julien, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6qn8 C D 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV Fab B13 BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.12 X-RAY DIFFRACTION 0.267 0.235 False True IGHV1 IGLV1 Lambda None None None None None 7tpr F NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/22 Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Butay, K.J., Zhu, J., Dandey, V.P., Hong, J., Kwon, H.J., Chen, C.Z., Duan, Z., Li, D., Ren, H., Liang, T., Martin, N., Esposito, D., Ortega-Rodriguez, U., Xu, M., Xie, H., Ho, M., Cachau, R., Borgnia, M.J. 2.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7v0v A NA 10 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7f4f S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/18/21 Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16 SYNTHETIC CONSTRUCT; HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ma, S., Chen, Y., Dai, A., Yin, W., Guo, J., Yang, D., Zhou, F., Jiang, Y., Wang, M.-W., Xu, H.E. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3j8v I M 0 B | A protein | protein NA | NA l1 | l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.14J Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 | human papillomavirus type 16 Guan, J., Hafenstein, S. 13.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV13 Kappa None None None None None 5vr9 A B 0 IMMUNE SYSTEM 05/10/17 CH1/Ckappa Fab based on Matuzumab HOMO SAPIENS homo sapiens homo sapiens Hendle, J. 2.15 X-RAY DIFFRACTION 0.244 0.210 False True IGHV1 IGKV1 Kappa None None None None None 6jfi K I 0 A protein zikv structural protein e VIRUS 04/10/19 The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q. 11 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 7bw0 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 04/12/20 Active huamn TGR5 complex with a synthetic agonist 23H ESCHERICHIA COLI; HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; VICUGNA PACOS vicugna pacos homo sapiens | rattus norvegicus | bos taurus Chen, G., Wang, X.K., Chen, Q., Hu, H.L., Ren, R.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6fy1 Y Z 0 X protein cap228 autologous scaffolded v1v2 IMMUNE SYSTEM 03/10/18 Crystal structure of a V2p-reactive RV144 vaccine-like antibody, CAP228-16H, in complex with a scaffolded autologous V1V2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Moore, P.L., Morris, L. 3.132 X-RAY DIFFRACTION 0.271 0.221 False True IGHV5 IGLV3 Lambda None None None None None 7e9b H L 0 C protein NA programmed cell death protein 1 IMMUNE SYSTEM 03/04/21 Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fan, S.L., Jiang, W.D. 1.78 X-RAY DIFFRACTION 0.210 0.170 False True IGHV3 IGKV1 Kappa None None None None None 4uik H L 0 03/30/15 crystal structure of quinine-dependent Fab 314.1 MUS MUSCULUS mus musculus mus musculus Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. 2.0 X-RAY DIFFRACTION 0.2185 0.1877 False False IGHV1 IGKV10 Kappa None None None None None 7lbf F E 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 01/07/21 CryoEM structure of the HCMV Trimer gHgLgO in complex with human Platelet-derived growth factor receptor alpha and neutralizing fabs 13H11 and MSL-109 HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN); HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus (strain merlin) Kschonsak, M., Rouge, L., Arthur, C.P., Hoangdung, H., Patel, N., Kim, I., Johnson, M., Kraft, E., Rohou, A.L., Gill, A., Martinez-Martin, N., Payandeh, J., Ciferri, C. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7czy J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2F11_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 1ibg H L 0 H Hapten OBN OUABAIN IMMUNOGLOBULIN 10/25/94 STRUCTURE AND SPECIFICITY OF THE ANTI-DIGOXIN ANTIBODY 40-50 MUS MUSCULUS mus musculus Jeffrey, P.D., Sheriff, S. 2.7 X-RAY DIFFRACTION unknown 0.209 False True IGHV2 IGKV3 Kappa None None None None None 3tpk A NA 0 IMMUNE SYSTEM 09/08/11 Crystal structure of the oligomer-specific KW1 antibody fragment CAMELIDAE camelidae Parthier, C., Morgado, I., Stubbs, M.T., Fandrich, M. 1.3 X-RAY DIFFRACTION 0.176 0.141 False True IGHV1 None None None None None 1vhp A NA 12 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4grw E NA 0 D protein interleukin-12 subunit beta IMMUNE SYSTEM 08/27/12 Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) LLAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C. 2.55 X-RAY DIFFRACTION 0.218 0.183 False True IGHV1 None None None None None 5gs0 H L 0 IMMUNE SYSTEM 08/13/16 Crystal structure of the complex of TLR3 and bi-specific diabody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 3.275 X-RAY DIFFRACTION 0.248 0.192 False True IGHV3 IGKV10 Kappa None None None None None 7bm5 B A 0 NA NA NA NA IMMUNE SYSTEM 01/19/21 Crystal structure of Fab1, the Fab fragment of the anti-BamA monoclonal antibody MAB1 HOMO SAPIENS homo sapiens homo sapiens White, P., Storek, K.M., Rutherford, S.T., Radford, S.E. 2.95 X-RAY DIFFRACTION 0.290 0.257 False True IGHV5 IGKV12 Kappa None None None None None 7rly C D 0 P peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide DRAAGQPAGDRADGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.67 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 IGKV1 Kappa None None None None None 3t77 B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 07/29/11 S25-2- A(2-4)KDO disaccharide complex MUS MUSCULUS mus musculus mus musculus mus musculus Nguyen, H.P., Seto, N.O., Mackenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.739 X-RAY DIFFRACTION 0.236 0.205 False True IGHV7 IGKV8 Kappa None None None None None 6bhz H L 0 IMMUNE SYSTEM 10/31/17 Trastuzumab Fab D185A (Light Chain) Mutant. HOMO SAPIENS homo sapiens homo sapiens DiDonato, M., Spraggon, G. 1.75 X-RAY DIFFRACTION 0.191 0.168 False True IGHV3 IGKV1 Kappa None None None None None 7tb8 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/21 Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4ht1 H L 0 T protein tumor necrosis factor ligand superfamily member 12 IMMUNE SYSTEM 10/31/12 Human TWEAK in complex with the Fab fragment of a neutralizing antibody HOMO SAPIENS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Lammens, A. 2.498 X-RAY DIFFRACTION 0.211 0.183 False False IGHV1 IGKV1 Kappa None None None None None 5czx C D 0 B protein neurogenic locus notch homolog protein 3 IMMUNE SYSTEM 08/01/15 Crystal structure of Notch3 NRR in complex with 20358 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hu, T., Fryer, C., Chopra, R., Clark, K. 2.1 X-RAY DIFFRACTION 0.226 0.190 False False IGHV1 IGKV1 Kappa 6e-10 -12.580852650099459 SPR TBD 6z3x A NA 0 NA NA NA NA IMMUNE SYSTEM 05/22/20 Crystal structure of the designed antibody DesAb-anti-HSA-P1 SYNTHETIC CONSTRUCT synthetic construct Costanzi, E., Sormanni, P., Ricagno, S. 1.74 X-RAY DIFFRACTION 0.220 0.193 False True IGHV3 NA NA None None None None None 6rag C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB in inward-facing wide conformation under turnover conditions THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 4.2 ELECTRON MICROSCOPY False True IGHV1 None None None None None 7x7d B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 SARS-CoV-2 Delta RBD and Nb22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, Y., Ye, S. 2.92 X-RAY DIFFRACTION 0.256 0.205 False True IGHV1 NA NA None None None None None 7kba H L 0 NA NA NA NA ANTIVIRAL PROTEIN, IMMUNE SYSTEM 10/01/20 Crystal structure of the HCMV pentamer-specific Fab 2-18 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., McLellan, J.S. 2.8 X-RAY DIFFRACTION 0.257 0.222 False True IGHV3 IGKV1 Kappa None None None None None 7f55 N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/21 Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Zhang, H., Chen, L., Mao, C., Shen, Q., Yang, D., Shen, D., Qin, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7f23 E NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/10/21 Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-Gs complex with Nb35 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Xiao, T., Zheng, S. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6p9i C D 0 IMMUNE SYSTEM 06/17/20 crystal structure of human anti staphylococcus aureus antibody STAU-399 Fab HOMO SAPIENS homo sapiens homo sapiens Dong, J., Crowe, J.E. 2.4 X-RAY DIFFRACTION 0.243 0.185 False True IGHV1 IGLV2 Lambda None None None None None 2oqj K J 0 L peptide peptide 2g12.1 (acppshvldmrsgtclaaegk) Immune system 01/31/07 Crystal structure analysis of Fab 2G12 in complex with peptide 2G12.1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Menendez, A., Scott, J.K., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.275 0.234 False False IGHV3 IGKV1 Kappa 2.00e-04 -5.04 SPR 25 18198210 6xvi A NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/22/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_A12 HELICOBACTER PYLORI (STRAIN G27); HELICOBACTER PYLORI G27 helicobacter pylori (strain g27), helicobacterpylori g27 Steyaert, J., Uchanski, T., Fischer, B. 2.596 X-RAY DIFFRACTION 0.250 0.224 False True IGHV1 NA NA None None None None None 5i76 B A 0 IMMUNE SYSTEM 02/16/16 Crystal structure of FM318, a recombinant Fab adopted from cetuximab HOMO SAPIENS/MUS MUSCULUS XENOGRAFT homo sapiens/mus musculus xenograft homo sapiens/mus musculus xenograft Sim, D.W., Kim, J.H., Seok, S.H., Seo, M.D., Kim, Y.P., Won, H.S. 1.922 X-RAY DIFFRACTION 0.201 0.166 False True IGHV2 IGKV5 Kappa None None None None None 7mfa C D 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA+P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.286 0.238 False True IGHV3 IGLV3 Lambda None None None None None 6ban B A 0 M protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/14/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.95 X-RAY DIFFRACTION 0.196 0.160 False True IGHV1 IGKV1 Kappa None None None None None 6zdh G I 0 C protein NA spike glycoprotein VIRAL PROTEIN 06/14/20 SARS-CoV-2 Spike glycoprotein in complex with a neutralizing antibody EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7sp8 B NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2; LAMA GLAMA lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7mtb H L 1 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6ch8 D E 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4.1 X-RAY DIFFRACTION 0.274 0.229 False True unknown unknown unknown None None None None None 5t5n O N 0 D protein bestrophin-1 (best1) MEMBRANE PROTEIN 08/31/16 Calcium-activated chloride channel bestrophin-1 (BEST1), triple mutant: I76A, F80A, F84A; in complex with an Fab antibody fragment, chloride, and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Long, S.B., Vaisey, G. 3.1 X-RAY DIFFRACTION 0.243 0.218 False False IGHV1 IGKV12 Kappa None None None None None 5gs1 J j 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 6pze H L 0 A protein neuraminidase IMMUNE SYSTEM 07/31/19 Crystal structure of human NA-45 Fab in complex with neuraminidase Y169aH mutant from A/Shanghai/2/2013 (H7N9) INFLUENZA A VIRUS (A/SHANGHAI/02/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/shanghai/02/2013(h7n9)) Zhu, X., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.197 0.156 False True IGHV4 IGLV1 Lambda None None None None None 2fee J O 0 A protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 12/15/05 Structure of the Cl-/H+ exchanger CLC-ec1 from E.Coli in NaBr ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C. 3.2 X-RAY DIFFRACTION 0.293 0.251 False True IGHV3 IGKV6D Kappa None None None None None 2g2r H L 0 L Hapten TNS 5-[{4-[(E)-2-(4-NITROPHENYL)VINYL]PHENYL}(METHYL)AMINO]PENTANOIC ACID IMMUNE SYSTEM 02/16/06 Green-fluorescent antibody 11G10 in complex with its hapten (nitro-stilbene derivative) MUS MUSCULUS mus musculus mus musculus mus musculus Debler, E.W., Wilson, I.A. 2.75 X-RAY DIFFRACTION 0.250 0.203 False False IGHV1 IGKV1 Kappa 1.3e-08 -10.758506170369841 Unknown TBD 2h9g H L 0 S protein tumor necrosis factor receptor superfamily member 10bprecursor IMMUNE SYSTEM/APOTOSIS 06/09/06 Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G., Compaan, D.M. 2.32 X-RAY DIFFRACTION 0.282 0.228 False True IGHV3 IGKV1 Kappa 5.00e-09 -11.32 SPR 16859704 1vhp A NA 2 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4xcn H L 0 H Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA); 2.9 A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.246 0.193 False True IGHV1 IGKV3 Kappa None None None None None 6ubi D E 0 F peptide hiv fusion peptide 512-519 IMMUNE SYSTEM/VIRAL PROTEIN 09/11/19 N123-VRC34.05 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 1.903 X-RAY DIFFRACTION 0.288 0.237 False True unknown IGKV1 Kappa None None None None None 3cxd H L 0 P peptide a peptide from osteopontin IMMUNE SYSTEM 04/24/08 Crystal structure of anti-osteopontin antibody 23C3 in complex with its epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Du, J., Yang, H., Zhong, C., Ding, J. 2.8 X-RAY DIFFRACTION 0.292 0.248 False False IGHV10 IGKV12 Kappa None None None None None 6ck8 C NA 0 IMMUNE SYSTEM 02/27/18 Crystal structure of anti-influenza single-domain llama antibody SD38 LAMA GLAMA lama glama Zhu, X., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.211 0.177 False True IGHV1 None None None None None 5a7x D C 0 A protein hiv-1 yu2 gp120 VIRAL PROTEIN 07/10/15 negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 17.0 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 4yhy B C 0 IMMUNE SYSTEM 02/27/15 Crystal structure of 309M3-B in complex with trimethylated Lys HOMO SAPIENS homo sapiens homo sapiens Hattori, T., Dementieva, I.S., Montano, S.P., Koide, S. 1.9 X-RAY DIFFRACTION 0.242 0.206 False True IGHV3 IGLV3 Lambda None None None None None 5anm D C 0 E protein ig epsilon chain c region 09/07/15 Crystal structure of IgE Fc in complex with a neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cohen, E.S., Dobson, C.L., Kack, H., Wang, B., Sims, D.A., Lloyd, C.O., England, E., Rees, D.G., Guo, H., Karagiannis, S.N., O'Brien, S., Persdotter, S., Ekdahl, H., Butler, R., Keyes, F., Oakley, S., Carlsson, M., Briend, E., Wilkinson, T., Anderson, I.K., Monk, P.D., vonWachenfeldt, K., Eriksson, P.O., Gould, H.J., Vaughan, T.J., May, R.D. 2.85 X-RAY DIFFRACTION 0.25993 0.19553 False True IGHV1 IGLV1 Lambda 1.95e-12 -15.975251068647337 Kinetic Exclusion Assay TBD 4nzu H L 0 IMMUNE SYSTEM 12/12/13 Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Wilson, I.A. 1.2 X-RAY DIFFRACTION 0.163 0.136 False False IGHV3 IGKV1 Kappa None None None None None 7lxz M L 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2L28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1u93 B A 0 C peptide gp41 peptide analog IMMUNE SYSTEM 08/09/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide Analog EQDKW-[Dap]-S (cyclic) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.37 X-RAY DIFFRACTION 0.235 0.238 False False IGHV2 IGKV1 Kappa None None None None None 6vo3 G J 0 C protein NA amc009 sosip.v4.2 envelope glycoprotein gp120 IMMUNE SYSTEM 01/29/20 AMC009 SOSIP.v4.2 in complex with PGV04 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., de Val, N., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6p9j H L 0 IMMUNE SYSTEM 06/17/20 crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab HOMO SAPIENS homo sapiens homo sapiens Dong, J., Crowe, J.E. 2.2 X-RAY DIFFRACTION 0.267 0.218 False True IGHV1 IGLV2 Lambda None None None None None 1v7n I M 0 X protein thrombopoietin IMMUNE SYSTEM/CYTOKINE 12/18/03 Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R. 3.3 X-RAY DIFFRACTION 0.305 0.167 False True IGHV6 IGKV4 Kappa None None None None None 4llu C D 0 IMMUNE SYSTEM 07/09/13 Structure of Pertuzumab Fab with light chain Clambda at 2.16A HOMO SAPIENS homo sapiens homo sapiens Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S. 2.16 X-RAY DIFFRACTION 0.273 0.222 False True IGHV3 IGKV1 Kappa None None None None None 6vmk E D 0 F protein NA fab y49r heavy chain HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 7s2s A NA 0 D protein NA interleukin-2 receptor subunit beta PROTEIN BINDING 09/03/21 nanobody bound to Interleukin-2Rbeta CAMELUS BACTRIANUS; HOMO SAPIENS camelus bactrianus homo sapiens Glassman, C.R., Jude, K.M., Yen, M., Garcia, K.C. 1.93 X-RAY DIFFRACTION 0.247 0.213 False True IGHV1 NA NA None None None None None 1ieh A NA 4 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 7mmo D E 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 04/30/21 LY-CoV1404 neutralizing antibody against SARS-CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hendle, J., Pustilnik, A., Sauder, J.M., Coleman, K.A., Boyles, J.S., Dickinson, C.D. 2.427 X-RAY DIFFRACTION 0.253 0.226 False True IGHV2 IGLV2 Lambda None None None None None 7lja E D 0 A protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel FHEIG mutant A198E in a Tl+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.77 X-RAY DIFFRACTION 0.243 0.201 False True IGHV1 IGKV4 Kappa None None None None None 7nvm n NA 0 e protein NA unknown CHAPERONE 03/15/21 Human TRiC complex in closed state with nanobody Nb18, actin and PhLP2A bound HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W., Structural Genomics Consortium (SGC) 3.1 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 5k9o A B 0 F protein hemagglutinin IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 31.b.09 in complex with Hemagglutinin H1 A/California/04/2009. INFLUENZA A VIRUS (STRAIN SWL A/CALIFORNIA/04/2009 H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain swla/california/04/2009 h1n1) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 3.387 X-RAY DIFFRACTION 0.346 0.291 False True IGHV1 IGKV2 Kappa None None None None None 5uko H L 0 IMMUNE SYSTEM 01/23/17 Structure of unliganded anti-gp120 CD4bs antibody DH522IA Fab MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I. 2.3 X-RAY DIFFRACTION 0.267 0.181 False True IGHV4 IGLV2 Lambda None None None None None 7rai I M 0 C protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 07/01/21 Cryo-EM structure of M4008_N1 Fab in complex with BG505 DS-SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 3.24 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 3zkn H L 0 A protein beta-secretase 2 IMMUNE SYSTEM/HYDROLASE 01/23/13 BACE2 FAB INHIBITOR COMPLEX HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 2.0 X-RAY DIFFRACTION 0.25141 0.20318 False True IGHV2 IGKV3 Kappa None None None None None 7cyh E D 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/03/20 Binding interface of SARS-CoV-2 RBD and its neutralizing antibody HB27 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, L. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 7nk6 F NA 0 NA NA NA NA VIRAL PROTEIN 02/17/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8204 INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 6.72 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4hg4 N O 0 C protein hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 3cm9 B M 4 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6nf2 S T 0 Q protein envelope glycoprotein gp120 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 6xul J K 0 NA NA NA NA ANTITUMOR PROTEIN 01/20/20 Apo Ab 5b1 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.230 0.168 False True IGHV3 IGLV1 Lambda None None None None None 2kqn NA B 1 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 3mug F E 0 C carbohydrate NAG polysaccharide IMMUNE SYSTEM 05/03/10 Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pejchal, R., Walker, L.M., Burton, D.R., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGLV2 Lambda None None None None None 6fy0 I M 0 A peptide cap45 v2 peptide IMMUNE SYSTEM 03/10/18 Crystal structure of a V2-directed, RV144 vaccine-like antibody from HIV-1 infection, CAP228-16H, bound to a heterologous V2 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Fernandes, M., Vijayakumar, B., Dirr, H.W., Sayed, Y., Moore, P.L., Morris, L. 2.57 X-RAY DIFFRACTION 0.250 0.210 False True IGHV5 IGLV3 Lambda None None None None None 6mi2 D E 0 F protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 09/19/18 Structure of the human 4-1BB / Utomilumab Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kimberlin, C.R., Chin, S.M., Roe-Zurz, Z., Xu, A., Yang, Y. 2.72 X-RAY DIFFRACTION 0.278 0.238 False True IGHV5 IGLV3 Lambda 6.900000000000001e-08 -9.769557801336566 SPR TBD 6vx4 H K 0 F | G protein | protein NA | NA cytolethal distending toxin subunit b | pertussis toxin-like subunit arta TOXIN 02/21/20 Density-fitted Model Structure of Antibody Variable Domains of TyTx11 in Complex with Typhoid Toxin MUS MUSCULUS; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHI STR. CT18 mus musculus mus musculus salmonella enterica subsp. enterica serovartyphi str. ct18 | salmonella enterica subsp. enterica serovartyphi str. ct18 Nguyen, T., Song, J. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 6opp G I 0 D protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 Asymmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2fjg H L 0 W protein vascular endothelial growth factor a HORMONE/GROWTH FACTOR/IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 2.8 X-RAY DIFFRACTION 0.239 0.199 False True IGHV3 IGKV1 Kappa 2.00e-08 -10.92 SPR 37 16373345 7tyf N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/13/22 Human Amylin1 Receptor in complex with Gs and rat amylin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6dez H L 0 IMMUNE SYSTEM 05/13/18 Anti-phosphotyrosine antibody PY20-4D5 Fab complexed with sulfate SYNTHETIC CONSTRUCT synthetic construct synthetic construct Mou, K., Leung, K., Wells, J.A. 3.2 X-RAY DIFFRACTION 0.296 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7wu2 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/05/22 Cryo-EM structure of the adhesion GPCR ADGRD1 in complex with miniGs HOMO SAPIENS; HOMO; LAMA GLAMA lama glama homo sapiens | homo sapiens Qu, X., Qiu, N., Wang, M., Zhao, Q., Wu, B. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1kxv C NA 0 A protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 1.6 X-RAY DIFFRACTION 0.229 0.205 False True IGHV1 2.50e-08 -10.37 SPR 11960990 6c9u H L 0 A protein 6-deoxyerythronolide-b synthase erya2, modules 3 and 4 TRANSFERASE/immune system 01/28/18 Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Deis, L.N., Li, X., Mathews, I.I., Khosla, C. 2.09 X-RAY DIFFRACTION 0.210 0.166 False True IGHV3 IGKV2 Kappa None None None None None 3qhf H L 0 IMMUNE SYSTEM 01/25/11 Crystal Structure of Fab del2D1, a deletion variant of anti-influenza antibody 2D1 HOMO SAPIENS homo sapiens homo sapiens Ekiert, D.C., Wilson, I.A. 1.655 X-RAY DIFFRACTION 0.209 0.183 False True IGHV2 IGLV1 Lambda None None None None None 2v17 H L 0 A peptide peptide fragment IMMUNE SYSTEM 05/22/07 Structure of the complex of antibody MN423 with a fragment of tau protein HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Sevcik, J., Skrabana, R., Csokova, N., Dvorsky, R., Novak, M. 1.65 X-RAY DIFFRACTION 0.218 0.156 False False IGHV7 IGKV16 Kappa None None None None None 6s8j Y U 0 E protein envelope glycoprotein 1 VIRAL PROTEIN 07/10/19 Structure of ZEBOV GP in complex with 5T0180 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 2.91 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7jhh H L 0 A protein NA 5'-amp-activated protein kinase catalytic subunit alpha-1 TRANSFERASE/IMMUNE SYSTEM 07/20/20 Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody HOMO SAPIENS; ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Yan, Y., Murkherjee, S., Zhou, X.E., Xu, T.H., Xu, H.E., Kossiakoff, A.A., Melcher, K. 3.92 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6d0u C D 0 B protein hemagglutinin ANTIVIRAL PROTEIN 04/11/18 Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Wu, N.C., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.268 0.254 False True IGHV3 IGKV1 Kappa None None None None None 7cx2 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/01/20 Cryo-EM structure of the PGE2-bound EP2-Gs complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Qu, C., Mao, C., Xiao, P., Shen, Q., Zhong, Y., Yang, F., Shen, D., Tao, X., Zhang, H., Yan, X., Zhao, R., He, J., Guan, Y., Zhang, C., Hou, G., Zhang, P., Yu, X., Guan, Y., Sun, J., Zhang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4qhu H L 0 C protein interleukin-17a IMMUNE SYSTEM 05/29/14 Crystal Structure of IL-17A/Fab6785 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Malia, T., Obmolova, G., Teplyakov, A. 2.2 X-RAY DIFFRACTION 0.216 0.171 False True IGHV3 IGLV3 Lambda None None None None None 7rlv C D 0 R peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRADGQPAGDRADGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.220 0.179 False True IGHV1 IGKV1 Kappa None None None None None 4r96 B A 0 Immune System 09/03/14 Structure of a Llama Glama Fab 48A2 against human cMet LLAMA GLAMA lama glama lama glama Klarenbeek, A., El Mazouari, K., Desmyter, A., Blanchetot, C., Hultberg, A., Roovers, R.C., Cambillau, C., Spinelli, S., Del-Favero, J., Verrips, T., de Haard, H., Achour, I. 3.31 X-RAY DIFFRACTION 0.261 0.217 False True IGHV1 IGKV4 Kappa None None None None None 7msq D E 0 B protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 05/12/21 Complex between the Fab arm of AB-3467 and the SARS-CoV-2 receptor binding domain (RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.29 X-RAY DIFFRACTION 0.245 0.194 False True IGHV4 IGKV1 Kappa None None None None None 3bgf H L 0 S protein spike protein s1 Viral Protein/Immune System 11/26/07 X-ray crystal structure of the SARS coronavirus spike receptor binding domain in complex with F26G19 Fab SARS CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus sars coronavirus Pak, J.E., Rini, J.M. 3.0 X-RAY DIFFRACTION 0.286 0.234 False False IGHV1 IGKV9 Kappa 2.60e-08 -10.34 SPR 25 19324051 3ifl H L 0 P peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 1.5 X-RAY DIFFRACTION 0.206 0.178 False True IGHV8 IGKV1 Kappa 8.40e-09 -11.01 SPR 25 19923222 6x58 C D 0 F protein NA gp41 mper peptide,putative fluoride ion transporter crcb MEMBRANE PROTEIN 05/25/20 MPER-Fluc-Ec2 bound to 10E8v4 antibody HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS; ESCHERICHIA COLI homo sapiens homo sapiens human immunodeficiency virus, escherichia coli McIlwain, B.C., Stockbridge, R.B. 3.26 X-RAY DIFFRACTION 0.295 0.251 False True IGHV3 IGLV3 Lambda None None None None None 6nb5 I M 0 IMMUNE SYSTEM 12/06/18 Crystal structure of anti- MERS-CoV human neutralizing LCA60 antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Walls, A.J., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Gopal, R., Dai, M., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.0 X-RAY DIFFRACTION 0.283 0.228 False True IGHV3 IGLV2 Lambda None None None None None 6nfn D C 0 C Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 3d9a H L 0 C protein lysozyme c HYDROLASE/IMMUNE SYSTEM 05/27/08 High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus DeSantis, M.E., Li, M., Shanmuganathan, A., Acchione, M., Walter, R., Wlodawer, A., Smith-Gill, S. 1.2 X-RAY DIFFRACTION 0.205 0.190 False True IGHV3 IGKV5 Kappa None None None None None 5nhw H L 0 IMMUNE SYSTEM 03/22/17 CRYSTAL STRUCTURE OF THE BIMAGRUMAB Fab HOMO SAPIENS homo sapiens homo sapiens Rondeau, J.-M. 1.78 X-RAY DIFFRACTION 0.204 0.178 False True IGHV1 IGLV2 Lambda None None None None None 7d8b B NA 0 A protein NA eukaryotic translation initiation factor 4e RNA BINDING PROTEIN 10/07/20 Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways HOMO SAPIENS homo sapiens homo sapiens Frosi, Y., Lin, Y.C., Jiang, S., Brown, C.J. 2.46 X-RAY DIFFRACTION 0.292 0.250 False True IGHV3 NA NA None None None None None 3cm9 A L 9 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7k9z H L 0 E protein NA spike glycoprotein IMMUNE SYSTEM 09/29/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with the Fab fragments of neutralizing antibodies 298 and 52 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Newton, J.C., Kucharska, I., Rujas, E., Cui, H., Julien, J.P. 2.95 X-RAY DIFFRACTION 0.287 0.261 False True IGHV1 IGKV1 Kappa None None None None None 2qtj C O 4 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4k3h NA B 0 A Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 7k63 N n 0 G | F | H protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/18/20 Cryo-EM structure of a chromatosome containing chimeric linker histone gH1.10-ncH1.4 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 3.03 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5o0w G NA 0 C protein fructose-bisphosphate aldolase LYASE 05/17/17 Crystal structure of the complex between Nb474 and Trypanosoma congolense fructose-1,6-bisphosphate aldolase TRYPANOSOMA CONGOLENSE (STRAIN IL3000); VICUGNA PACOS vicugna pacos trypanosoma congolense (strain il3000) Pinto, J., Magez, S., Sterckx, Y. 2.57 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 7.382999999999999e-11 -13.822203424535738 SPR TBD 2ojz I M 0 IMMUNE SYSTEM 01/15/07 Anti-DNA antibody ED10 MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Sanguineti, S., Wilson, I.A., de Prat-Gay, G. 2.73 X-RAY DIFFRACTION 0.264 0.201 False False IGHV1 IGKV1 Kappa None None None None None 7e3l F G 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/09/21 Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Li, T., Liu, F., Gao, Y., Ji, X., Yang, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1i9j H L 0 H Hapten TES TESTOSTERONE IMMUNE SYSTEM 03/20/01 TESTOSTERONE COMPLEX STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus mus musculus Valjakka, J., Takkinenz, K., Teerinen, T., Soderlund, H., Rouvinen, J. 2.6 X-RAY DIFFRACTION 0.255 0.188 False True IGHV5 IGKV1 Kappa None None None None None 7p77 D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5vig H L 0 Z protein zika virus envelope protein diii IMMUNE SYSTEM 04/16/17 Crystal structure of anti-Zika antibody Z006 bound to Zika virus envelope protein DIII ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Keeffe, J.R., West Jr., A.P., Gristick, H.B., Bjorkman, P.J. 3.0 X-RAY DIFFRACTION 0.257 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6sne B A 0 O peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.9 X-RAY DIFFRACTION 0.261 0.218 False True IGHV4 IGKV1 Kappa None None None None None 4ckd J N 0 A protein beta-galactosidase HYDROLASE/IMMUNE SYSTEM 01/03/14 Model of complex between the E.coli enzyme beta-galactosidase and four single chain Fv antibody domains scFv13R4. MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Vinothkumar, K.R., McMullan, G., Henderson, R. 13.0 ELECTRON MICROSCOPY False True IGHV3 IGKV5 Kappa None None None None None 6yhq H L 0 NA NA NA NA IMMUNE SYSTEM 03/30/20 Crystal Structure of Fab F5.18.6, anti-Plasmodium vivax AMA1 MUS MUSCULUS mus musculus mus musculus Bentley, G.A., Saul, F.A., Vulliez-le Normand, B. 1.89 X-RAY DIFFRACTION 0.239 0.185 False False IGHV5 IGKV4 Kappa None None None None None 7kxj H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/04/20 SARS-CoV-2 spike protein in complex with Fab 15033-7, 3-""up"", asymmetric SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J. 6.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6oed A B 0 NA NA NA NA IMMUNE SYSTEM 03/27/19 CRYSTAL STRUCTURE OF THE RV144 C1-C2 SPECIFIC ANTIBODY CH55 FAB HOMO SAPIENS homo sapiens homo sapiens Yan, F., Van, V., Tolbert, W.D., Pazgier, M. 2.461 X-RAY DIFFRACTION 0.312 0.256 False True IGHV1 IGKV3 Kappa None None None None None 4g6k H L 0 IMMUNE SYSTEM 07/19/12 Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state homo sapiens homo sapiens Blech, M., Hoerer, S. 1.9 X-RAY DIFFRACTION 0.211 0.183 False True IGHV4 IGKV1 Kappa None None None None None 6vos H L 0 NA NA NA NA IMMUNE SYSTEM 01/31/20 Crystal structure of macaque anti-HIV-1 antibody RM20J MACACA MULATTA macaca mulatta macaca mulatta Yuan, M., Wilson, I.A. 2.299 X-RAY DIFFRACTION 0.211 0.181 False True IGHV4 IGKV1 Kappa None None None None None 2qtj A L 2 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 2zpk H L 0 P peptide proteinase-activated receptor 4 IMMUNE SYSTEM 07/16/08 Crystal structure of P20.1 Fab fragment in complex with its antigen peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Nogi, T., Sanagawa, T., Takagi, J. 1.8 X-RAY DIFFRACTION 0.204 0.172 False False IGHV9 IGLV1 Lambda 1.47e-06 -7.95 SPR 25 18787202 5y9f Z Y 0 H protein NA major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 7chc H L 0 R protein NA spike glycoprotein PROTEIN BINDING/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab and BD-368-2 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 2.71 X-RAY DIFFRACTION 0.286 0.212 False True IGHV3 IGKV3 Kappa None None None None None 6rbb K NA 0 IMMUNE SYSTEM 05/13/20 CRYSTAL STRUCTURE OF the VhH-domain of anti-IL-17A antibody netakimab LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 2.45 X-RAY DIFFRACTION 0.280 0.216 False True IGHV1 None None None None None 7e7x H L 0 A protein NA spike protein s1 VIRAL PROTEIN 02/28/21 SARS-CoV-2 Spike Protein N terminal domain in Complex with N11 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z., Shuo, D., Xiao, J. 2.78 X-RAY DIFFRACTION 0.279 0.248 False True IGHV1 IGLV2 Lambda None None None None None 3ulv H L 0 A protein toll-like receptor 3 IMMUNE SYSTEM 11/11/11 Structure of quaternary complex of human TLR3ecd with three Fabs (Form2) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 3.522 X-RAY DIFFRACTION 0.253 0.231 False True IGHV5 IGKV1 Kappa None None None None None 6chb I L 0 F protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 6.801 X-RAY DIFFRACTION 0.417 0.318 False True unknown IGLV3 Lambda None None None None None 3fo1 H L 0 H Hapten BZH 5-[(2-AMINO-1H-BENZIMIDAZOL-6-YL)AMINO]-5-OXOPENTANOIC ACID IMMUNE SYSTEM 12/27/08 Crystal structure of hapten complex of catalytic elimination antibody 13G5 (Glu(L39)Ala mutant) MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.281 0.225 False True IGHV2 IGKV1 Kappa None None None None None 7k90 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C144 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Esswein, S.R., Bjorkman, P.J. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 4nco H G 0 E protein bg505 sosip gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/24/13 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Lyumkis, D., Ward, A.B., Wilson, I.A. 4.7 X-RAY DIFFRACTION 0.389 0.375 False True IGHV4 IGLV3 Lambda None None None None None 5vn3 M O 0 J protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/28/17 Cryo-EM model of B41 SOSIP.664 in complex with soluble CD4 (D1-D2) and fragment antigen binding variable domain of 17b HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Pallesen, J., Ward, A.B. 3.7 ELECTRON MICROSCOPY / HOMOLOGY MODEL False True IGHV1 IGKV3 Kappa None None None None None 4hdi H L 0 IMMUNE SYSTEM 10/02/12 Crystal Structure of 3E5 IgG3 FAB from mus musculus MUS MUSCULUS mus musculus mus musculus Janda, A., Eryilmaz, E., Kim, J., Cordero, R.J.B., Cowburn, D., Casadevall, A. 2.449 X-RAY DIFFRACTION 0.263 0.208 False True IGHV5 IGKV1 Kappa None None None None None 5n2k N M 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 6sge B NA 0 C protein rho-related gtp-binding protein rhob IMMUNE SYSTEM 08/04/19 Crystal structure of Human RHOB-GTP in complex with nanobody B6 HOMO SAPIENS homo sapiens homo sapiens Soulie, S., Gence, R., Cabantous, S., Lajoie-Mazenc, I., Favre, G., Pedelacq, J.D. 1.5 X-RAY DIFFRACTION 0.188 0.161 False True IGHV3 None None None None None 4d3c H L 0 A protein hepatocyte growth factor 10/21/14 Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68. HOMO SAPIENS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Kang, Y.J., Kim, K.L., Cho, H.S., Chung, J.H. 2.62 X-RAY DIFFRACTION 0.29758 0.26760 False False IGHV1 IGKV1 Kappa None None None None None 7bu7 B NA 0 A protein NA endolysin,endolysin,beta-1 adrenergic receptor chimera MEMBRANE PROTEIN 04/04/20 Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9 ENTEROBACTERIA PHAGE T4; HOMO SAPIENS; CAMELIDAE MIXED LIBRARY camelidae mixed library enterobacteria phage t4, homo sapiens Xu, X., Kaindl, J., Clark, M., Hubner, H., Hirata, K., Sunahara, R., Gmeiner, P., Kobilka, B.K., Liu, X. 2.6 X-RAY DIFFRACTION 0.270 0.244 False True IGHV1 NA NA None None None None None 5bk5 B A 0 IMMUNE SYSTEM 09/12/17 Crystal structure of the anti-circumsporozoite protein 663 germline antibody HOMO SAPIENS homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 3.0 X-RAY DIFFRACTION 0.314 0.257 False True IGHV3 IGKV2 Kappa None None None None None 4rau H G 0 I protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 3chn A L 5 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 6vmk Z Y 0 a protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 3eo9 H L 0 IMMUNE SYSTEM 09/26/08 Crystal structure the Fab fragment of Efalizumab HOMO SAPIENS homo sapiens homo sapiens Li, S., Ding, J. 1.8 X-RAY DIFFRACTION 0.217 0.189 False True IGHV3 IGKV1 Kappa None None None None None 7a4d C NA 0 E peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 5uk4 q NA 0 Q protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 6n4r J I 0 A | B | F protein | protein | peptide NA | NA | NA nav1.7 vsd2-navab chimera | nav1.7 vsd2-navab chimera | beta/omega-theraphotoxin-tp2a MEMBRANE PROTEIN 11/20/18 CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2 ARCOBACTER BUTZLERI (STRAIN RM4018); HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus arcobacter butzleri (strain rm4018), homosapiens | arcobacter butzleri (strain rm4018), homosapiens | thrixopelma pruriens Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M. 4.2 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 6x19 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/18/20 Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Belousoff, M.J., Zhang, X., Danev, R. 2.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7kkz H L 0 NA NA NA NA ANTIVIRAL PROTEIN 10/28/20 Crystal structure of mouse anti-HIV potent neutralizing antibody M4H2K1 MUS MUSCULUS mus musculus mus musculus Kumar, S., Wilson, I.A. 1.5 X-RAY DIFFRACTION 0.216 0.183 False True IGHV6 IGKV3 Kappa None None None None None 4py8 I J 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 03/26/14 Crystal structure of Fab 3.1 in complex with the 1918 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Dreyfus, C. 2.91 X-RAY DIFFRACTION 0.242 0.193 False True IGHV3 IGKV1 Kappa 1e-09 -12.27819680469229 SPR TBD 7o85 NA N 0 M | O protein | protein NA | NA protective antigen pa-63 | fab TOXIN 04/14/21 Anthrax toxin prepore in complex with the neutralizing Fab cAb29 BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus bacillus anthracis | mus musculus Hoelzgen, F., Zalk, R., Alcalay, R., Cohen-Schwartz, S., Garau, G., Shahar, A., Mazor, O., Frank, G.A. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6zqk A NA 0 NA NA NA NA ANTITUMOR PROTEIN 07/09/20 HER2-binding scFv-Fab fusion 841 MUS MUSCULUS mus musculus Kast, F., Schwill, M., Stueber, J.C., Pfundstein, S., Nagy-Davidescu, G., Monne Rodriguez, J.M., Seehusen, F., Richter, C.P., Honegger, A., Hartmann, K.P., Weber, T.G., Kroener, F., Ernst, P., Piehler, J., Plueckthun, A. 2.2 X-RAY DIFFRACTION 0.241 0.202 False True IGHV3 NA NA None None None None None 6weq G H 0 B protein NA non-structural protein 1 VIRAL PROTEIN 04/02/20 DENV1 NS1 in complex with neutralizing 2B7 Fab fragment DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Akey, D.L., Smith, J.L. 3.2 X-RAY DIFFRACTION 0.261 0.207 False False IGHV1 IGKV3 Kappa None None None None None 4rzc H L 0 H carbohydrate M6P ALPHA-D-MANNOSE-6-PHOSPHATE IMMUNE SYSTEM 12/19/14 Fv M6P-1 in complex with mannose-6-phosphate ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Blackler, R.J., Evans, D.W., Evans, S.V., Muller-Loennies, S. 2.723 X-RAY DIFFRACTION 0.267 0.226 False True IGHV1 IGKV1 Kappa None None None None None 6ey0 E NA 0 A protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 N-terminal part (residues 30-212) of PorM with the llama naobody nb01 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Roche, J., Cambillau, C., Roussel, A. 2.4 X-RAY DIFFRACTION 0.242 0.213 False True IGHV1 None None None None None 6mek B D 0 A protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HEPACIVIRUS C; HOMO SAPIENS homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.290 0.223 False True IGHV1 IGKV1 Kappa None None None None None 7wvm A B 0 E protein NA programmed cell death protein 1 IMMUNE SYSTEM/ANTITUMOR PROTEIN 02/10/22 The complex structure of PD-1 and cemiplimab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lu, D., Xu, Z.P., Liu, K.F., Tan, S.G., Gao, G.F., Chai, Y. 3.4 X-RAY DIFFRACTION 0.287 0.247 False True IGHV3 IGKV1 Kappa None None None None None 6krz H I 0 C protein NA adiponectin receptor protein 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/22/19 Crystal structure of the human adiponectin receptor 1 D208A mutant HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Tanabe, H., Fujii, Y., Okada-Iwabu, M., Iwabu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S. 3.05 X-RAY DIFFRACTION 0.273 0.216 False True IGHV1 IGKV12 Kappa None None None None None 5muq H L 0 IMMUNE SYSTEM 01/13/17 Crystal structure of DC8E8 Fab at pH 7.0 containing a Zn atom MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.62 X-RAY DIFFRACTION 0.279 0.212 False False IGHV1 IGKV8 Kappa None None None None None 6z1z A NA 0 NA NA NA NA IMMUNE SYSTEM 05/14/20 Structure of the anti-CD9 nanobody 4C8 LAMA GLAMA lama glama Neviani, N., Oosterheert, W., Pearce, N.M., Lutz, M., Kroon-Batenburg, L.M.J., Gros, P. 1.7 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 NA NA None None None None None 7f4i N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/18/21 Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ma, S., Chen, Y., Dai, A., Yin, W., Guo, J., Yang, D., Zhou, F., Jiang, Y., Wang, M.-W., Xu, H.E. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1fl6 H L 0 H Hapten AAH ? IMMUNE SYSTEM 08/11/00 THE HAPTEN COMPLEXED GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4 MUS MUSCULUS; HOMO SAPIENS homo sapiens mus musculus homo sapiens Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G. 2.8 X-RAY DIFFRACTION 0.271 0.216 False True IGHV3 IGKV1 Kappa 2.50e-05 SPR 11535051 7kqb K J 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/14/20 SARS-CoV-2 spike glycoprotein:Fab 5A6 complex I SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Asarnow, D., Charles, C., Cheng, Y. 2.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4xcy E F 0 A Hapten 44G (2S)-3-{[(R)-{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidylglycerol (06:0 PG) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 3.96 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 IGKV3 Kappa None None None None None 7bm5 D C 0 NA NA NA NA IMMUNE SYSTEM 01/19/21 Crystal structure of Fab1, the Fab fragment of the anti-BamA monoclonal antibody MAB1 HOMO SAPIENS homo sapiens homo sapiens White, P., Storek, K.M., Rutherford, S.T., Radford, S.E. 2.95 X-RAY DIFFRACTION 0.290 0.257 False True IGHV5 IGKV12 Kappa None None None None None 5aco H L 0 A protein hiv-1 envelope glycoprotein 08/17/15 Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.36 ELECTRON MICROSCOPY False True IGHV4 IGLV2 Lambda None None None None None 1hez B A 0 E protein protein l ANTIBODY 11/27/00 antibody-antigen complex HOMO SAPIENS; FINEGOLDIA MAGNA homo sapiens homo sapiens finegoldia magna Graille, M., Stura, E.A., Housden, N.G., Bottomley, S.P., Taussig, M.J., Sutton, B.J., Gore, M.G., Charbonnier, JB. 2.7 X-RAY DIFFRACTION 0.278 0.215 False False IGHV3 IGKV1 Kappa 1.45e-07 -9.32 Other 25 11587642 6zer H L 0 E protein NA rbd VIRAL PROTEIN/IMMUNE SYSTEM 06/16/20 Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 3.8 X-RAY DIFFRACTION 0.251 0.212 False True IGHV3 IGKV1 Kappa None None None None None 7bub G I 0 B protein NA dengue virus serotype2 e protein VIRUS 04/06/20 Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 6.5 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5x8m B C 0 A protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 03/03/17 PD-L1 in complex with durvalumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, H.T. 2.661 X-RAY DIFFRACTION 0.219 0.181 False True IGHV3 IGKV3 Kappa None None None None None 7rw2 I K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/19/21 Cryo-EM structure of NTD-directed neutralizing antibody 5-7 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3f12 B A 0 IMMUNE SYSTEM 10/27/08 Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus HOMO SAPIENS homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.95 X-RAY DIFFRACTION 0.320 0.300 False True IGHV3 IGKV3 Kappa None None None None None 7s4g C D 0 G peptide NA lymphocyte antigen 6 complex locus protein g6d SIGNALING PROTEIN 09/08/21 Fab fragment bound to the Cter peptide of Ly6G6D HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rouge, L., Lupardus, P. 2.2 X-RAY DIFFRACTION 0.235 0.192 False True IGHV1 IGKV4 Kappa None None None None None 6fg2 F G 0 IMMUNE SYSTEM 01/09/18 CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA84. HOMO SAPIENS homo sapiens homo sapiens Bertrand, T., Pouzieux, S. 2.788 X-RAY DIFFRACTION 0.263 0.238 False True IGHV3 IGLV3 Lambda None None None None None 6dbd C NA 0 IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R326 LAMA GLAMA lama glama Brooks, C.L., Toride King, M., Huh, I. 1.755 X-RAY DIFFRACTION 0.182 0.160 False True unknown unknown unknown None None None None None 3nif E F 0 C protein integrin alphaiib beta3 CELL ADHESION/BLOOD CLOTTING 06/15/10 The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.4 X-RAY DIFFRACTION 0.216 0.176 False True IGHV14 IGKV14 Kappa None None None None None 5xxy H L 0 A protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 07/05/17 Complex structure of PD-L1 with atezolizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhou, A., Zhang, F. 2.9 X-RAY DIFFRACTION 0.295 0.236 False True IGHV3 IGKV1 Kappa 9.960000000000001e-09 -10.916327402549168 ELISA TBD 7l06 G E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/11/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Henderson, R., Acharya, P. 3.3 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6k2i A NA 13 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 4xx1 M O 0 J protein phosphatidylcholine-sterol acyltransferase Hydrolase/Immune system 01/29/15 Low resolution structure of LCAT in complex with Fab1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T. 3.6 X-RAY DIFFRACTION 0.280 0.196 False True IGHV3 IGLV3 Lambda None None None None None 6war H NA 0 G protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 3d0l B A 0 C peptide hyb3k peptide construct IMMUNE SYSTEM 05/01/08 Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 FP-MPER Hyb3K construct 514GIGALFLGFLGAAGS528KK-Ahx-655KNEQELLELDKWASLWN671 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bryson, S., Julien, J.P., Pai, E.F. 2.35 X-RAY DIFFRACTION 0.229 0.211 False False IGHV2 IGKV1 Kappa None None None None None 6jfh M N 0 C protein zikv structural e protein ANTIVIRAL PROTEIN 04/10/19 The asymmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q. 20 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 2bx5 NA H 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 2qtj D N 7 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 3p0g B NA 0 A protein beta-2 adrenergic receptor, lysozyme SIGNALING PROTEIN, Hydrolase 09/28/10 Structure of a nanobody-stabilized active state of the beta2 adrenoceptor HOMO SAPIENS, ENTEROBACTERIA PHAGE T4; LAMA GLAMA lama glama homo sapiens, enterobacteria phage t4 Rasmussen, S.G.F., Choi, H.-J., Fung, J.J., Pardon, E., Casarosa, P., Chae, P.S., DeVree, B.T., Rosenbaum, D.M., Thian, F.S., Kobilka, T.S., Schnapp, A., Konetzki, I., Sunahara, R.K., Gellman, S.H., Pautsch, A., Steyaert, J., Weis, W.I., Kobilka, B.K. 3.5 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 8.4e-11 -13.745742430538545 Unknown TBD 5iop B A 0 IMMUNE SYSTEM 03/08/16 Cetuximab Fab in complex with 4-bromophenylalanine meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.499 X-RAY DIFFRACTION 0.226 0.177 False True IGHV2 IGKV5 Kappa 2.9e-05 -6.190396711462486 Unknown TBD 5mu2 I J 0 T peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 6peh A B 0 IMMUNE SYSTEM 06/20/19 Crystal structure of rabbit monoclonal anti-HIV antibody 1C2 HOMO SAPIENS homo sapiens homo sapiens Liban, T., Pancera, M. 2.296 X-RAY DIFFRACTION 0.255 0.219 False True IGHV1 IGKV1 Kappa None None None None None 3v6f E F 0 IMMUNE SYSTEM 12/19/11 Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound MUS MUSCULUS mus musculus mus musculus Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. 2.52 X-RAY DIFFRACTION 0.220 0.179 False False IGHV5 IGKV8 Kappa None None None None None 2otu B A 0 P peptide peptide antigen IMMUNE SYSTEM 02/09/07 Crystal structure of Fv polyglutamine complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Li, P. 1.68 X-RAY DIFFRACTION 0.214 0.200 False True IGHV5 IGLV3 Lambda None None None None None 7ebz E F 0 B | A | C protein | protein | protein NA | NA | NA capsid protein vp2 | capsid protein vp1 | capsid protein vp3 VIRUS 03/11/21 EV-D68 in complex with 2H12 Fab (state S1) HUMAN ENTEROVIRUS D68; MUS MUSCULUS mus musculus mus musculus human enterovirus d68 | human enterovirus d68 | human enterovirus d68 Xu, C., Cong, Y. 3.09 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV9 Kappa None None None None None 5vsh C D 0 IMMUNE SYSTEM 05/11/17 CH1/Clambda Fab based on Pertuzumab HOMO SAPIENS homo sapiens homo sapiens Hendle, J. 2.55 X-RAY DIFFRACTION 0.255 0.207 False True IGHV3 IGKV1 Kappa None None None None None 7fcp H L 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 07/15/21 Crystallographic structure of two neutralizing antibodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, P., Jin, T. 2.4 X-RAY DIFFRACTION 0.245 0.191 False True IGHV1 IGLV2 Lambda None None None None None 4j4p H L 0 A protein ig epsilon chain c region IMMUNE SYSTEM 02/07/13 The complex of human IgE-Fc with two bound Fab fragments HOMO SAPIENS homo sapiens homo sapiens homo sapiens Drinkwater, N., Sutton, B.J. 2.91 X-RAY DIFFRACTION 0.284 0.236 False True IGHV6 IGLV1 Lambda 4e-08 -10.092595930642474 SPR TBD 3upa NA B 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 1.8 X-RAY DIFFRACTION 0.283 0.229 False True IGKV1 Kappa None None None None None 6y6c D d 0 A protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 02/26/20 TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Williams, E., Mukhopadhyay, S.M.M., McKinley, G., Gruslund, S., Wigren, E., Persson, H., Arrowsmith, C.H., Edwards, A., von Delft, F., Bountra, C., Davis, J.B., Di Daniel, E., Burgess-Brown, N., Bullock, A. 2.26 X-RAY DIFFRACTION 0.216 0.191 True True unknown unknown unknown None None None None None 5wdu T S 0 Q protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True IGHV4 unknown unknown None None None None None 7rdw G I 0 N protein NA glycoprotein 120 IMMUNE SYSTEM 07/12/21 Crystal Structure of FH1 Fab bound to HXb2 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Weidle, C., Pancera, M. 3.55 X-RAY DIFFRACTION 0.295 0.260 False True IGHV1 IGKV3 Kappa None None None None None 4w2o E NA 0 F protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody B Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS (STRAIN MUSOKE-80) lama glama lake victoria marburgvirus (strain musoke-80) Taylor, A.B., Garza, J.A. 3.2 X-RAY DIFFRACTION 0.285 0.227 False True IGHV1 None None None None None 7p5w K NA 0 E protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1r0a H L 0 B protein reverse transcriptase Transferase/immune system/DNA 09/19/03 Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Tuske, S., Ding, J., Arnold, E. 2.8 X-RAY DIFFRACTION 0.272 0.239 False False IGHV8 IGKV10 Kappa None None None None None 7vyr H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/15/21 Crystal structure of SARS-CoV-2 Spike RBD in complex with the D27 neutralizing antibody Fab fragment HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jeong, B.-S., Oh, B.-H. 2.2 X-RAY DIFFRACTION 0.235 0.192 False True IGHV1 IGLV3 Lambda None None None None None 5iv2 B A 0 IMMUNE SYSTEM 03/18/16 Cetuximab Fab in complex with Arg9Cir meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.481 X-RAY DIFFRACTION 0.211 0.165 False True IGHV2 IGKV5 Kappa None None None None None 2kqm NA A 5 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6df2 H L 0 D peptide leu-ptr-leu IMMUNE SYSTEM 05/13/18 Improved anti-phosphotyrosine antibody 4G10-S5-4D5 Fab complexed with phosphotyrosine peptide SYNTHETIC CONSTRUCT synthetic construct synthetic construct synthetic construct Mou, K., Leung, K., Wells, J.A. 2.6 X-RAY DIFFRACTION 0.230 0.177 False True IGHV3 IGKV1 Kappa 5.720000000000001e-08 -9.880679659658352 Unknown TBD 5a2l H h 0 P peptide modified antigen tn IMMUNE SYSTEM 05/20/15 Crystal structure of scFv-SM3 in complex with APD-CGalNAc-RP MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Martinez-Saez, N., Castro-Lopez, J., Valero-Gonzalez, J., Madariaga, D., Companon, I., Somovilla, V.J., Salvado, M., Asensio, J.L., Jimenez-Barbero, J., Avenoza, A., Busto, J.H., Bernardes, G.J.L., Peregrina, J.M., Hurtado-Guerrero, R., Corzana, F. 1.79 X-RAY DIFFRACTION 0.20447 0.18442 True True unknown unknown unknown None None None None None 7kzx D C 0 B protein NA cadmium and zinc efflux pump fief MEMBRANE PROTEIN 12/10/20 Cryo-EM structure of YiiP-Fab complex in Apo state SHEWANELLA ONEIDENSIS; HOMO SAPIENS homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Fan, S., Koide, A., Koide, S., Beckstein, O., Stokes, D.L. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5fhb H L 0 IMMUNE SYSTEM 12/21/15 Crystal Structure of Protective Ebola Virus Antibody 100 HOMO SAPIENS homo sapiens homo sapiens Gilman, M.S.A., McLellan, J.S. 1.973 X-RAY DIFFRACTION 0.194 0.159 False True IGHV4 IGLV3 Lambda None None None None None 5vz1 D C 0 IMMUNE SYSTEM 05/26/17 Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains) HOMO SAPIENS homo sapiens homo sapiens Radwanska, M.J., Derewenda, U., Kossiakoff, A., Derewenda, Z.S. 2.112 X-RAY DIFFRACTION 0.268 0.218 False True IGHV3 IGKV1 Kappa None None None None None 5vkd H L 0 A protein nucleoprotein IMMUNE SYSTEM 04/21/17 Crystal structure of C-terminal domain of Ebola (Bundibugyo) nucleoprotein in complex with Fab fragment BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus Radwanska, M.J., Derewenda, U., Kossiakoff, A., Derewenda, Z.S. 1.749 X-RAY DIFFRACTION 0.202 0.176 False True IGHV3 IGKV1 Kappa None None None None None 7l3n D E 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/18/20 SARS-CoV 2 Spike Protein bound to LY-CoV555 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Goldsmith, J.A., McLellan, J.S. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 1sbs H L 0 MONOCLONAL ANTIBODY 04/08/98 CRYSTAL STRUCTURE OF AN ANTI-HCG FAB MUS MUSCULUS mus musculus mus musculus Fotinou, C., Beauchamp, J., Emsley, P., Dehaan, A., Schielen, W.J.G., Bos, E., Isaacs, N.W. 2.0 X-RAY DIFFRACTION 0.240 0.180 False False IGHV6 IGKV8 Kappa None None None None None 6iyn A NA 14 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 3eyf B A 0 E peptide synthetic peptide IMMUNE SYSTEM 10/20/08 Crystal structure of anti-human cytomegalovirus antibody 8f9 plus gB peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.3 X-RAY DIFFRACTION 0.230 0.210 False True IGHV3 IGKV3 Kappa 9.40e-08 -9.3 ITC 24 18772881 7bbj M N 0 B protein NA 5'-nucleotidase IMMUNE SYSTEM 12/17/20 CD73 in complex with the humanized antagonistic antibody mAb19 HOMO SAPIENS; UNIDENTIFIED unidentified unidentified homo sapiens Boettcher, J., Han, F. 2.72 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 IGKV1 Kappa None None None None None 6vn0 G J 0 E | C protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 01/29/20 BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Shin, M., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 7q9k H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-32 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7e5s I K 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1hh9 B A 0 C peptide pep-2 IMMUNE SYSTEM/PEPTIDE 12/21/00 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Hahn, M., Wessner, H., Schneider-Mergener, J., Hohne, W. 2.7 X-RAY DIFFRACTION 0.333 0.282 False False IGHV1 IGKV14 Kappa 1.00e-05 Other 4 10990450 6ot1 S T 0 P protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7vab N NA 0 A | B protein | protein NA | NA mini-gs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/28/21 Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhao, F.H., Zhou, Q.T., Cong, Z.T., Hang, K.N., Zou, X.Y., Zhang, C., Chen, Y., Dai, A.T., Liang, A.Y., Ming, Q.Q., Wang, M., Chen, L.N., Xu, P.Y., Chang, R.L., Feng, W.B., Xia, T., Zhang, Y., Wu, B.L., Yang, D.H., Zhao, L.H., Xu, H.E., Wang, M.W. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6ikm E e 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 5m6i NA A 0 IMMUNE SYSTEM 10/25/16 Crystal structure of non-cardiotoxic Bence-Jones light chain dimer M8 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.2 X-RAY DIFFRACTION 0.227 0.195 False False IGLV2 Lambda None None None None None 5t1d H L 0 B protein NA envelope glycoprotein l VIRAL PROTEIN 08/18/16 Crystal structure of EBV gHgL/gp42/E1D1 complex EPSTEIN-BARR VIRUS (STRAIN B95-8); EPSTEIN-BARR VIRUS (STRAIN GD1); MUS MUSCULUS mus musculus mus musculus epstein-barr virus (strain b95-8) Sathiyamoorthy, K., Jardetzky, T.S. 3.1 X-RAY DIFFRACTION 0.265 0.212 False False IGHV1 IGKV1 Kappa None None None None None 5nbm F NA 0 D | A protein | protein NA | NA actin | actin-related protein 4 HYDROLASE 03/02/17 Crystal structure of the Arp4-N-actin(ATP-state) heterodimer bound by a nanobody SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS; TRICHOPLUSIA NI vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) Knoll, K.R., Eustermann, S., Hopfner, K.P. 3.4 X-RAY DIFFRACTION 0.193 0.152 False True IGHV1 None None None None None 7my2 D NA 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/20/21 CryoEM structure of neutralizing nanobody Nb30 in complex with SARS-CoV2 spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Xu, K., Kwong, P.D. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3fo9 B A 0 B Hapten DIK 5-{[4-(5-METHYL-3-OXOHEX-4-EN-1-YL)PHENYL]AMINO}-5-OXOPENTANOIC ACID IMMUNE SYSTEM 12/29/08 Crystal structure of aldolase antibody 33F12 Fab' in complex with hapten 1,3-diketone MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.249 0.215 False True IGHV6 IGKV1 Kappa None None None None None 6waq A NA 0 B protein spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/25/20 Crystal structure of the SARS-CoV-1 RBD bound by the cross-reactive single-domain antibody SARS VHH-72 LAMA GLAMA; HUMAN SARS CORONAVIRUS lama glama human sars coronavirus Wrapp, D., McLellan, J.S. 2.2 X-RAY DIFFRACTION 0.236 0.203 False True IGHV1 None None None None None 2kqn NA B 7 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1xiw D C 0 A | F protein | protein NA | NA t-cell surface glycoprotein cd3 epsilon chain | t-cell surface glycoprotein cd3 delta chain membrane protein/Immune System 09/22/04 Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Arnett, K.L., Harrison, S.C., Wiley, D.C. 1.9 X-RAY DIFFRACTION 0.241 0.204 False True IGHV1 IGKV10 Kappa None None None None None 6eqi B NA 0 C | A protein | protein NA | NA serine/threonine-protein kinase pink1, putative | ubiquitin TRANSFERASE 10/13/17 Structure of PINK1 bound to ubiquitin HOMO SAPIENS; LAMA GLAMA; PEDICULUS HUMANUS CORPORIS lama glama pediculus humanus corporis | homo sapiens Schubert, A.F., Gladkova, C., Pardon, E., Wagstaff, J.L., Freund, S.M.V., Steyaert, J., Maslen, S., Komander, D. 3.1 X-RAY DIFFRACTION 0.234 0.203 False True IGHV1 None None None None None 5j56 B NA 0 A protein ricin HYDROLASE/IMMUNE SYSTEM 04/01/16 RTA-V1C7 LAMA GLAMA; RICINUS COMMUNIS lama glama ricinus communis Rudolph, M.J. 1.8 X-RAY DIFFRACTION 0.210 0.173 False True IGHV1 3.2000000000000005e-09 -11.589048932503637 SPR TBD 4nc2 B NA 0 A protein toxin b IMMUNE SYSTEM 10/23/13 Crystal structure of TcdB-B1 bound to B39 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 2.5 X-RAY DIFFRACTION 0.229 0.192 False True IGHV1 None None None None None 7wdf F G 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with two S3H3 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 6wzt G F 0 C protein NA hemagglutinin ANTIVIRAL PROTEIN 05/14/20 CryoEM structure of influenza hemagglutinin A/Victoria/361/2011 in complex with cyno antibody 3B10 INFLUENZA A VIRUS; MACACA FASCICULARIS macaca fascicularis macaca fascicularis influenza a virus Qiu, Y., Zhou, Y., Darricarrere, N. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6k5i C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/29/19 Crystal structure of the E148D/R147A/F317A mutant CLC-ec1 in the presence of 20 mM NaBr ESCHERICHIA COLI MS 117-3; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 117-3 Park, K., Lim, H.H. 3.022 X-RAY DIFFRACTION 0.264 0.210 False True IGHV4 IGKV4 Kappa None None None None None 5njg C D 0 B protein atp-binding cassette sub-family g member 2 TRANSPORT PROTEIN 03/28/17 Structure of an ABC transporter: part of the structure that could be built de novo MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Taylor, N.M.I., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P. 3.78 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 6nf2 O P 0 I protein envelope glycoprotein gp41 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 7whz B D 0 A protein NA spike protein s1 VIRAL PROTEIN 01/01/22 SARS-CoV-2 spike protein in complex with three human neutralizing antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Li, S., Sun, H., Zheng, Z., Wang, S. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6iw0 H L 0 A protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv in complex with YFV-17D sE in postfusion state YELLOW FEVER VIRUS (STRAIN 17D VACCINE); HOMO SAPIENS homo sapiens homo sapiens yellow fever virus (strain 17d vaccine) Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 3.6 X-RAY DIFFRACTION 0.336 0.277 False True IGHV4 IGKV1 Kappa None None None None None 7wi0 B D 0 A protein NA spike protein s1 VIRAL PROTEIN 01/01/22 SARS-CoV-2 Omicron variant spike in complex with three human neutralizing antibodies Homo sapiens homo sapiens homo sapiens homo sapiens Zheng, Q., Li, S., Sun, H., Zheng, Z., Wang, S. 3.82 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6s8j H L 0 A protein envelope glycoprotein 1 VIRAL PROTEIN 07/10/19 Structure of ZEBOV GP in complex with 5T0180 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 2.91 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 5y0a F G 0 B protein protein e VIRUS/IMMUNE SYSTEM 07/15/17 Cryo-EM structure of zika virus complexed with Fab of ZKA190 at pH 8.0 and 37 celsius degree ZIKA VIRUS (STRAIN MR 766); HOMO SAPIENS homo sapiens homo sapiens zika virus (strain mr 766) Wang, J.Q., Lok, S.M. 22 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 6wmw H L 0 B protein NA gdnf family receptor alpha-like IMMUNE SYSTEM 04/21/20 GFRAL receptor bound with two antibody Fabs (3P10, 25M22) HOMO SAPIENS homo sapiens homo sapiens homo sapiens White, A., Lakshminarasimhan, D., Olland, A., Suto, R.K. 2.91 X-RAY DIFFRACTION 0.290 0.222 False True IGHV9 IGKV3 Kappa None None None None None 7lkg A B 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM/ANTIGEN 02/02/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.151 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Xu, K., Kwong, P.D. 2.02 X-RAY DIFFRACTION 0.254 0.213 False True IGHV1 IGKV4 Kappa None None None None None 4p49 A a 0 NA NA NA NA IMMUNE SYSTEM 03/12/14 The structure of a chicken anti-prostate specific antigen scFv GALLUS GALLUS gallus gallus Conroy, P.J., Law, R.H.P., Gilgunn, S., Hearty, S., Llyod, G., Caradoc-Davies, T.T., O'Kennedy, R.J., Whisstock, J.C. 1.4 X-RAY DIFFRACTION 0.214 0.183 True True unknown unknown unknown None None None None None 2kh2 B b 18 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6b7z C D 0 A protein insulin-degrading enzyme HYDROLASE/IMMUNE SYSTEM 10/05/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 6.5 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 4f33 B A 0 IMMUNE SYSTEM 05/08/12 Crystal Structure of therapeutic antibody MORAb-009 MUS MUSCULUS Xia, D., Ma, J., Tang, W.K., Esser, L. 1.749 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 IGKV4 Kappa None None None None None 4xbp E F 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylethanolamine (06:0 PE) HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.94 X-RAY DIFFRACTION 0.271 0.228 False True IGHV1 IGKV3 Kappa None None None None None 3dwt G NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 6mdt H L 0 G protein surface protein gp120 VIRAL PROTEIN 09/05/18 Crystal structure of the B41 SOSIP.664 Env trimer with PGT124 and 35O22 Fabs, in P63 space group HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Sarkar, A., Wilson, I.A. 3.816 X-RAY DIFFRACTION 0.311 0.294 False True IGHV4 unknown unknown None None None None None 7cqc H L 0 A protein NA putative zinc metalloprotease aq_1964,pa14 from podoplanin,putative zinc metalloprotease aq_1964 HYDROLASE/IMMUNE SYSTEM 08/10/20 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 181 and 184 RATTUS NORVEGICUS; AQUIFEX AEOLICUS VF5; HOMO SAPIENS rattus norvegicus rattus norvegicus aquifex aeolicus vf5, homo sapiens Aruga, R., Tamura-Sakaguchi, R., Nogi, T. 2.5 X-RAY DIFFRACTION 0.258 0.230 False True IGHV5 IGLV3 Lambda None None None None None 5da4 C NA 0 IMMUNE SYSTEM 08/19/15 Structure of a nanobody recognizing the fumarate transporter SLC26Dg LAMA GLAMA lama glama Dutzler, R., Geertsma, E.R., Chang, Y., Shaik, F.R. 2.4 X-RAY DIFFRACTION 0.242 0.233 False True IGHV1 None None None None None 7vv5 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/04/21 Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yu, L., Fang, Y. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2fbj H L 0 H carbohydrate NAG polysaccharide IMMUNOGLOBULIN 08/18/89 REFINED CRYSTAL STRUCTURE OF THE GALACTAN-BINDING IMMUNOGLOBULIN FAB J539 AT 1.95-ANGSTROMS RESOLUTION MUS MUSCULUS mus musculus Bhat, T.N., Padlan, E.A., Davies, D.R. 1.95 X-RAY DIFFRACTION unknown unknown False True IGHV4 IGKV4 Kappa None None None None None 6a0x C D 0 IMMUNE SYSTEM 06/06/18 Crystal structure of broadly neutralizing antibody 13D4 MUS MUSCULUS mus musculus mus musculus Li, S., Li, T. 2.3 X-RAY DIFFRACTION 0.243 0.205 False False IGHV1 IGKV6 Kappa None None None None None 7jw0 G F 0 E protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/20 SARS-CoV-2 spike in complex with the S304 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Walls, A.C., Park, Y.J., Tortorici, M.A., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2vdl H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Re-refinement of Integrin AlphaIIbBeta3 Headpiece HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.75 X-RAY DIFFRACTION 0.191 0.144 False False IGHV14 IGKV14 Kappa None None None None None 1ae6 H L 0 IMMUNOGLOBULIN 03/06/97 IGG-FAB FRAGMENT OF MOUSE MONOCLONAL ANTIBODY CTM01 MUS MUSCULUS mus musculus mus musculus Banfield, M.J., Brady, R.L. 3.0 X-RAY DIFFRACTION 0.311 0.210 False False IGHV1 IGKV2 Kappa None None None None None 7jwp O P 0 X peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 6nfc K N 0 B | F protein | protein NA | NA hiv-1 env bg505 md64 n332-gt5 sosip gp41 | hiv-1 env bg505 md64 n332-gt5 sosip gp120 VIRAL PROTEIN 12/19/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 3qxw B NA 0 IMMUNE SYSTEM 03/02/11 Free structure of an anti-methotrexate CDR1-4 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.85 X-RAY DIFFRACTION 0.238 0.189 False True IGHV1 None None None None None 4ub0 H L 0 NA NA NA NA IMMUNE SYSTEM 08/11/14 New design for monovalent bispecific IgG through cysteine engineering of the CH1-CL interface HOMO SAPIENS homo sapiens homo sapiens Oganesyan, V.Y., Dall'Acqua, W.F. 2.2 X-RAY DIFFRACTION 0.252 0.232 False True IGHV3 IGKV1 Kappa None None None None None 6pe9 K M 0 J protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 06/20/19 Crystal Structure of CD40 complexed to FAB516 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Argiriadi, M.A. 3.13 X-RAY DIFFRACTION 0.255 0.216 False True IGHV3 IGKV4 Kappa None None None None None 6cue h l 0 d protein unknown VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 6ccb D E 0 C protein glycoprotein 120 VIRAL PROTEIN 02/06/18 Crystal structure of 253-11 SOSIP trimer in complex with 10-1074 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Moyo, T., Ereno-Orbea, J., Dorfman, J., Julien, J.P. 6.5 X-RAY DIFFRACTION 0.366 0.298 False True IGHV4 unknown unknown None None None None None 6x7w H L 0 G peptide NA hiv fusion peptide 512-519 IMMUNE SYSTEM/VIRAL PROTEIN 05/30/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP49.02 in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.248 0.214 False True IGHV5 IGKV5 Kappa None None None None None 6b0n D E 0 G protein envelope glycoprotein gp140 Viral protein/immune system 09/14/17 Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Irimia, A., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.346 0.335 False True unknown IGLV2 Lambda None None None None None 6wzk C D 0 F protein NA c-x-c motif chemokine 3 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL3 HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Durbin, J.D., Druzina, Z. 1.8 X-RAY DIFFRACTION 0.209 0.178 False True IGHV1 IGKV3 Kappa None None None None None 6wtu K L 0 J protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 273264 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.55 X-RAY DIFFRACTION 0.255 0.208 False True IGHV3 IGLV3 Lambda None None None None None 5aaw H h 0 I protein dengue serotype 4 envelope protein domain 3 07/30/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency DENGUE VIRUS; MUS MUSCULUS mus musculus dengue virus Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R. 3.27 X-RAY DIFFRACTION 0.26258 0.22661 True True unknown unknown unknown 4.320000000000001e-09 -11.411241859183763 SPR TBD 7rth H G 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 4r4n W X 0 V | i protein | peptide NA | NA m48u1 peptide | unknown VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | synthetic construct Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 2kqn NA A 5 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6c5h H L 0 H carbohydrate GP1 polysaccharide IMMUNE SYSTEM, SUGAR BINDING PROTEIN 01/16/18 S25-5 Fab in complex with Chlamydiaceae-specific LPS antigen MUS MUSCULUS mus musculus mus musculus mus musculus Evans, S.V., Haji-Ghassemi, O. 1.99 X-RAY DIFFRACTION 0.226 0.187 False False IGHV2 IGKV1 Kappa None None None None None 5any I M 0 B | A protein | protein NA | NA e2 | e1 VIRUS 09/08/15 Electron cryo-microscopy of chikungunya virus in complex with neutralizing antibody Fab CHK265 CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Fox, J.M., Long, F., Edeling, M.A., Lin, H., Duijl-Richter, M., Fong, R.H., Kahle, K.M., Smit, J.M., Jin, J., Simmons, G., Doranz, B.J., Crowe, J.E., Fremont, D.H., Rossmann, M.G., Diamond, M.S. 16.9 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 7z1b F NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-A10 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.3 X-RAY DIFFRACTION 0.243 0.198 False True IGHV1 NA NA None None None None None 5vl2 H NA 0 H Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 2p46 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: se5b-ortho-2 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.299 0.221 False True IGHV1 1.16e-07 -9.61 Other 30 18445622 7ki6 H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 10/23/20 Structure of the HeV F glycoprotein in complex with the 1F5 neutralizing antibody HENDRA HENIPAVIRUS; MUS MUSCULUS mus musculus mus musculus hendra henipavirus Dang, H.V., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 4ubd G H 0 F | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 08/12/14 Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Shore, D.A., Yang, H., Cho, M., Donis, R.O., Stevens, J. 3.5 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 IGKV3 Kappa None None None None None 6vbo H L 0 C peptide envelope glycoprotein gp160 IMMUNE SYSTEM/VIRAL PROTEIN 12/19/19 Crystal structure of anti-HIV-1 antibody DH813 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 1.683 X-RAY DIFFRACTION 0.208 0.175 False True IGHV5 IGKV2 Kappa None None None None None 1gig H L 0 IMMUNOGLOBULIN 01/20/93 REFINED THREE-DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A MURINE IGG1, LAMBDA ANTIBODY MUS MUSCULUS mus musculus mus musculus Bizebard, T., Knossow, M. 2.3 X-RAY DIFFRACTION unknown unknown False True IGHV2 IGLV1 Lambda None None None None None 2ltq C B 1 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 6ad8 C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148D mutant CLC-ec1 in 50 mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 3.3 X-RAY DIFFRACTION 0.284 0.227 False False IGHV4 IGKV4 Kappa None None None None None 6xv8 D NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/21/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_G10 LAMA GLAMA; HELICOBACTER PYLORI (STRAIN G27) lama glama, helicobacter pylori (strain g27) Steyaert, J., Uchanski, T., Fischer, B. 3.15 X-RAY DIFFRACTION 0.297 0.255 False True IGHV1 NA NA None None None None None 7wd9 E F 0 B protein NA spike glycoprotein VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with three S3H3 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 3dsf H L 0 P peptide a peptide from osteopontin IMMUNE SYSTEM 07/12/08 Crystal structure of anti-osteopontin antibody 23C3 in complex with W43A mutated epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Du, J., Zhong, C., Yang, H., Ding, J. 2.8 X-RAY DIFFRACTION 0.297 0.241 False False IGHV10 IGKV12 Kappa None None None None None 7zf9 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron BA.2 RBD in complex with COVOX-150 Fab (P21) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.265 0.222 False True IGHV3 IGKV1 Kappa None None None None None 3j7e D C 0 IMMUNE SYSTEM 06/23/14 Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments MUS MUSCULUS mus musculus mus musculus Lee, H., Brendle, S.A., Bywaters, S.M., Christensen, N.D., Hafenstein, S. 13.6 ELECTRON MICROSCOPY False False IGHV1 IGKV8 Kappa None None None None None 6dzl H K 0 E | B | F protein | protein | protein NA | NA | NA ebola virus makona gp2 | ebola virus makona gp1 | ebola virus makona gp2 VIRAL PROTEIN 07/05/18 Ebola virus Makona variant GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus | zaire ebolavirus | zaire ebolavirus Murin, C.D., Ward, A.B. 4.14 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6gxx H L 0 PROTEIN BINDING 06/27/18 Fab fragment of an antibody selective for alpha-1-antitrypsin in the native conformation MUS MUSCULUS mus musculus mus musculus Elliston, E.L.K., Miranda, E., Perez, J., Lomas, D.A., Irving, J.A. 1.85 X-RAY DIFFRACTION 0.223 0.186 False False IGHV5 IGKV3 Kappa None None None None None 6wix D E 0 B protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 04/10/20 Crystal Structure of HIV-1 MI369 RnS-DS.SOSIP Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Olia, A., Kwong, P.D. 2.67 X-RAY DIFFRACTION 0.270 0.225 False True unknown unknown unknown None None None None None 5mud NA B 0 IMMUNE SYSTEM 01/13/17 Crystal structure of an amyloidogenic light chain dimer H6 HOMO SAPIENS homo sapiens Oberti, L., Bacarizo, J., Maritan, M., Rognoni, P., Bolognesi, M., Ricagno, S. 2.34 X-RAY DIFFRACTION 0.249 0.205 False True IGLV1 Lambda None None None None None 7mfa H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA+P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.286 0.238 False True IGHV3 IGLV3 Lambda None None None None None 2z4q B A 0 IMMUNE SYSTEM 06/22/07 Crystal structure of a murine antibody FAB 528 MUS MUSCULUS mus musculus mus musculus Nakanishi, T., Tsumoto, K., Asano, R., Kondo, H., Kumagai, I. 2.3 X-RAY DIFFRACTION 0.228 0.191 False False IGHV1 IGKV1 Kappa None None None None None 7x9e A B 0 E peptide NA spike peptide IMMUNE SYSTEM/VIRAL PROTEIN 03/15/22 Crystal structure of the 76E1 Fab in complex with a SARS-CoV-2 spike peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Zhang, T., Ding, J., Sun, X., Sun, B. 2.6 X-RAY DIFFRACTION 0.243 0.195 False True IGHV3 IGLV2 Lambda None None None None None 7a69 C B 0 A protein NA multidrug resistance protein 1 TRANSPORT PROTEIN 08/25/20 Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nosol, K., Locher, K.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7vv3 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/04/21 Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yu, L., Fang, Y. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7lf2 K L 0 J protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3j93 H L 0 IMMUNE SYSTEM 12/02/14 Fitting of Fab into the cryoEM density map of EV71 procapsid in complex with Fab22A12 MUS MUSCULUS mus musculus mus musculus Shingler, K.L., Cifuente, J.O., Ashley, R.E., Makhov, A.M., Conway, J.F., Hafenstein, S. 8.8 ELECTRON MICROSCOPY False False IGHV1 IGKV6 Kappa None None None None None 5ig7 A B 0 C peptide peptide pro-leu-gln-pro-gln-gln-pro-phe-pro IMMUNE SYSTEM 02/27/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPQQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.97 X-RAY DIFFRACTION 0.236 0.190 False True IGHV3 IGLV4 Lambda None None None None None 2ltq C B 9 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 5ocl H NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA vicugna pacos Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 5wi9 F E 0 B protein beta-klotho STRUCTURAL PROTEIN 07/18/17 Crystal structure of KL with an agonist Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Johnstone, S., Min, X., Wang, Z. 2.7 X-RAY DIFFRACTION 0.270 0.216 False True IGHV3 IGKV3 Kappa 8.6e-11 -13.731800994840723 SPR TBD 7pg8 N M 0 Q protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 4evn O P 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 5f7y D NA 0 B protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group A type-1 hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.44 X-RAY DIFFRACTION 0.205 0.176 False True IGHV1 None None None None None 7ps7 A B 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-40 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.9 X-RAY DIFFRACTION 0.284 0.233 False True IGHV4 IGLV3 Lambda None None None None None 3a6c H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 08/28/09 Crystal Structure of HyHEL-10 Fv mutant LN92D complexed with hen egg white lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Yokota, A., Tsumoto, K., Shiroishi, M., Nakanishi, T., Kondo, H., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.216 0.186 False True IGHV3 IGKV5 Kappa 7.14e-09 -11.28 ITC 30 20038580 1fl6 B A 0 B Hapten AAH ? IMMUNE SYSTEM 08/11/00 THE HAPTEN COMPLEXED GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4 MUS MUSCULUS; HOMO SAPIENS homo sapiens mus musculus homo sapiens Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G. 2.8 X-RAY DIFFRACTION 0.271 0.216 False True IGHV3 IGKV1 Kappa 2.50e-05 SPR 11535051 7mzj C D 0 B protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 93 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.4 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGLV1 Lambda None None None None None 5v8l I M 0 D protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/22/17 BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 1za6 H G 0 IMMUNE SYSTEM 04/05/05 The structure of an antitumor CH2-domain-deleted humanized antibody HOMO SAPIENS homo sapiens homo sapiens Larson, S.B., Day, J.S., Glaser, S., Braslawsky, G., McPherson, A. 2.8 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV4 Kappa None None None None None 5dd1 H L 0 IMMUNE SYSTEM 08/24/15 Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques MACACA MULATTA macaca mulatta macaca mulatta Zhang, R., Verkoczy, L., Wiehe, K., Alam, S.M., Nicely, N.I., Santra, S., Bradley, T., Pemble, C., Gao, F., Montefiori, D.C., Bouton-Verville, H., Kelsoe, G., Parks, R., Foulger, A., Tomaras, G., Keple, T.B., Moody, M.A., Liao, H.-X., Haynes, B.F. 1.597 X-RAY DIFFRACTION 0.228 0.185 False True IGHV4 IGKV1 Kappa None None None None None 6vi1 J I 0 Q peptide NA terminase, large subunit IMMUNE SYSTEM 01/11/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 2.4 X-RAY DIFFRACTION 0.239 0.189 False True IGHV3 IGKV1 Kappa None None None None None 5xf1 C D 0 A protein glucagon receptor,endolysin,glucagon receptor SIGNALING PROTEIN 04/06/17 Structure of the Full-length glucagon class B G protein-coupled receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens, enterobacteria phage t4 Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.Y., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. 3.19 X-RAY DIFFRACTION 0.231 0.205 False True IGHV3 IGKV1 Kappa None None None None None 6w16 H L 0 F protein fusion glycoprotein f0,envelope glycoprotein fusion IMMUNE SYSTEM 06/03/20 Crystal structure of a human metapneumovirus monomeric fusion protein complexed with 458 Fab HUMAN METAPNEUMOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human metapneumovirus, human immunodeficiencyvirus 1 Huang, J., Mousa, J.J. 3.1 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV1 Kappa None None None None None 1ohq B NA 0 IMMUNOGLOBULIN 05/30/03 Crystal structure of HEL4, a soluble human VH antibody domain resistant to aggregation HOMO SAPIENS homo sapiens Jespers, L., Schon, O., James, L.C., Veprintsev, D., Winter, G. 2.0 X-RAY DIFFRACTION 0.26 0.182 False True IGHV3 None None None None None 7ly2 G I 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2M28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 1xf4 B A 0 IMMUNE SYSTEM 09/13/04 Structure of ligand-free Fab DNA-1 in space group P321 solved from crystals with perfect hemihedral twinning MUS MUSCULUS mus musculus mus musculus Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J. 2.5 X-RAY DIFFRACTION 0.224 0.183 False True IGHV1 IGKV12 Kappa None None None None None 2adj B A 0 IMMUNE SYSTEM 07/20/05 Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium MUS MUSCULUS mus musculus mus musculus Zhou, T., Hamer, D.H., Hendrickson, W.A., Sattentau, Q.J., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.300 0.213 False False IGHV5 IGKV17 Kappa Unknown TBD 7mfr B A 0 P peptide NA gly-gly-met IMMUNE SYSTEM 04/10/21 Crystal Structure of a Fab fragment bound to peptide GGM ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Sudhamsu, J. 2.848 X-RAY DIFFRACTION 0.260 0.211 False True IGHV1 IGKV1 Kappa None None None None None 7nx8 A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the K417T mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 1.95 X-RAY DIFFRACTION 0.246 0.223 False True IGHV3 IGKV3 Kappa None None None None None 1ine H L 0 H Hapten EOT [(1-[(BIS-CARBOXYMETHYL-AMINO)-METHYL]-2-{4-[3-(2-HYDROXY-ETHYL)-THIOUREIDO]-PHENY}-ETHYL)-CARBOXYMETHYL-AMINO]-ACETIC ACID IMMUNOGLOBULIN 06/14/93 HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE MUS MUSCULUS mus musculus mus musculus mus musculus Love, R.A., Butler, W.F. 2.8 X-RAY DIFFRACTION unknown 0.176 False False IGHV5 IGLV1 Lambda None None None None None 6h5n C B 0 A protein gametocyte surface protein p45/48 CELL INVASION 07/25/18 Plasmodium falciparum Pfs48/45 C-terminal domain bound to monoclonal antibody 85RF45.1 PLASMODIUM FALCIPARUM; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus plasmodium falciparum Lennartz, F., Higgins, M.K. 3.23 X-RAY DIFFRACTION 0.282 0.261 False True IGHV5 IGLV3 Lambda None None None None None 2gfb F E 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 6gwn B NA 0 A protein plasminogen activator inhibitor 1 HYDROLASE 06/25/18 Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 2.03 X-RAY DIFFRACTION 0.250 0.208 False True IGHV1 None None None None None 7v5n B A 0 D nucleic-acid NA dna (5'-d(*gp*cp*gp*gp*tp*tp*gp*gp*tp*gp*gp*tp*ap*gp*tp*tp*ap*cp*gp*tp*tp*cp* gp*c)-3') IMMUNE SYSTEM/DNA 08/17/21 Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Hishiki, A., Tong, J., Todoroki, K., Hashimoto, H. 1.7 X-RAY DIFFRACTION 0.210 0.178 False True IGHV3 IGKV1 Kappa None None None None None 6nc3 H L 0 B | A protein | protein NA | NA hiv-1 env amc011 v4.2 sosip gp41 | hiv-1 env amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Torres, J.L., Ward, A.B. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5acm NA A 0 08/17/15 Mcg immunoglobulin variable domain with methylene blue HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Salwinski, L., Phillips, M.L., Ly, A.T., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 1.05 X-RAY DIFFRACTION 0.12234 0.11033 False True IGLV2 Lambda None None None None None 1mvf B NA 0 D peptide pemi-like protein 1 IMMUNE SYSTEM 09/25/02 MazE addiction antidote CAMELUS DROMEDARIUS; ESCHERICHIA COLI camelus dromedarius escherichia coli Loris, R., Marianovsky, I., Lah, J., Laeremans, T., Engelberg-Kulka, H., Glaser, G., Muyldermans, S., Wyns, L. 1.65 X-RAY DIFFRACTION 0.249 0.218 False True IGHV1 None None None None None 2yss B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 04/03/07 Crystal structure of Humanized HYHEL-10 FV mutant(HQ39KW47Y)-HEN lysozyme complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Nakanishi, T., Tsumoto, K., Yokota, A., Kondo, H., Kumagai, I. 2.4 X-RAY DIFFRACTION 0.265 0.218 False True IGHV4 IGKV3 Kappa None None None None None 7s0c H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-017 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7coe H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM 08/04/20 Crystal structure of Receptor binding domain of MERS-CoV and KNIH90-F1 Fab complex HOMO SAPIENS; MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Lee, J.Y., Song, J.Y., Lee, H.S., Hong, E., Jang, T.H. 2.05 X-RAY DIFFRACTION 0.223 0.176 False True IGHV1 IGKV3 Kappa None None None None None 6pci O R 0 B | E protein | protein NA | NA virion spike glycoprotein | virion spike glycoprotein,virion spike glycoprotein,ebolavirus (makona) gp2 immune system, viral protein 06/17/19 EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus | zaire ebolavirus, ebola virus Ward, A.B., Murin, C.D., Alkutkar, T. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 6wzl C D 0 F protein NA c-x-c motif chemokine 7 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL7 HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Durbin, J.D., Druzina, Z. 2.29 X-RAY DIFFRACTION 0.222 0.193 False True IGHV1 IGKV3 Kappa None None None None None 5uea H L 0 D protein histone chaperone asf1 IMMUNE SYSTEM 12/29/16 Structure of antigen-Fab complex with Histone chaperone ASF1 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C) homo sapiens homo sapiens saccharomyces cerevisiae (strain atcc 204508 /s288c) Bailey, L.J., Kossiakoff, A.A. 1.701 X-RAY DIFFRACTION 0.207 0.154 False True IGHV3 IGKV1 Kappa None None None None None 1kxt F NA 0 E protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 2.0 X-RAY DIFFRACTION 0.236 0.203 False True IGHV1 2.35e-07 -9.04 SPR 11960990 1otu E F 0 B protein voltage-gated clc-type chloride channel eric MEMBRANE PROTEIN 03/23/03 Structure of the Escherichia coli ClC Chloride channel E148Q mutant and Fab Complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Dutzler, R., Campbell, E.B., MacKinnon, R. 3.3 X-RAY DIFFRACTION 0.325 0.294 False False IGHV4 IGKV4 Kappa None None None None None 6xmi E D 0 F peptide NA terminase, large subunit VIRAL PROTEIN, IMMUNE SYSTEM 06/30/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 1.51 X-RAY DIFFRACTION 0.203 0.167 False True IGHV3 IGKV1 Kappa None None None None None 7rso G J 0 C protein NA amc016 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/11/21 AMC016 SOSIP.v4.2 in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Bader, D.L.V., Cottrell, C.A., Ward, A.B. 4.1 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 4m5y H L 0 IMMUNE SYSTEM 08/08/13 Crystal structure of broadly neutralizing Fab 5J8 HOMO SAPIENS homo sapiens homo sapiens Lee, P.S., Wilson, I.A. 1.55 X-RAY DIFFRACTION 0.186 0.172 False True IGHV4 IGLV3 Lambda None None None None None 7wpf Z NA 0 NA NA NA NA VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA lama glama Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7e7y C D 0 E protein NA spike protein s1 VIRAL PROTEIN 02/28/21 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-623 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wei, Y., Xiao, J. 2.41 X-RAY DIFFRACTION 0.241 0.197 False True IGHV3 IGLV2 Lambda None None None None None 1r3k B A 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 10/02/03 potassium channel KcsA-Fab complex in low concentration of Tl+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y., MacKinnon, R. 2.8 X-RAY DIFFRACTION 0.273 0.238 False False IGHV1 IGKV5 Kappa None None None None None 3kym L K 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 2ez0 C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 11/10/05 Crystal structure of the S107A/E148Q/Y445A mutant of EcClC, in complex with a FaB fragment ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lobet, S., Dutzler, R. 3.54 X-RAY DIFFRACTION 0.296 0.258 False False IGHV4 IGKV4 Kappa None None None None None 6u0l I J 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN 08/14/19 Asymmetrically open conformational state (Class I) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 4nrz H L 0 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66.6 HOMO SAPIENS homo sapiens homo sapiens Ofek, G., Yang, Y., Kwong, P.D. 2.42 X-RAY DIFFRACTION 0.216 0.177 False True IGHV5 IGKV1 Kappa None None None None None 6ca6 H L 0 IMMUNE SYSTEM 01/29/18 Crystal structure of PCT64_35S, a broadly neutralizing anti-HIV antibody. HOMO SAPIENS homo sapiens homo sapiens Murrell, S., Wilson, I.A. 2.43 X-RAY DIFFRACTION 0.245 0.201 False True IGHV3 IGKV3 Kappa None None None None None 3q3g D C 0 G protein integrin alpha-m IMMUNE SYSTEM/CELL ADHESION 12/21/10 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 2.7 X-RAY DIFFRACTION 0.244 0.211 False False IGHV14 IGKV8 Kappa 4.97e-09 -11.32 SPR 25 22095715 4jzj A B 0 D protein interleukin-3 receptor subunit alpha CYTOKINE RECEPTOR/IMMUNE SYSTEM 04/03/13 Crystal Structure of Receptor-Fab Complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Broughton, S.E., Parker, M.W. 2.801 X-RAY DIFFRACTION 0.244 0.185 False False IGHV5 IGKV4 Kappa 4e-09 -11.456840020052727 SPR TBD 7l0n C D 0 S protein NA spike protein s1 VIRAL PROTEIN/HYDROLASE 12/11/20 Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Dillen, J., Nix, J.C., Croll, T.I., Corti, D. 2.78 X-RAY DIFFRACTION 0.325 0.290 False True IGHV1 IGKV3 Kappa None None None None None 5w4l B C 0 A protein NA clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 06/12/17 Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in complex with HIV-1 clade A/E gp120, the CD4 mimetic M48U1, and the antibody N5-i5. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 2.92 X-RAY DIFFRACTION 0.292 0.231 False True IGHV1 IGKV3 Kappa None None None None None 7r4q D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/09/22 The SARS-CoV-2 spike in complex with the 1.29 neutralizing nanobody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Melero, R., Arranz, R., Fernandez, L.A. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6vja H L 0 C protein b-lymphocyte antigen cd20 IMMUNE SYSTEM 01/15/20 Structure of CD20 in complex with rituximab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rohou, A., Croll, T.I. 3.3 ELECTRON MICROSCOPY False True IGHV1 IGKV4 Kappa None None None None None 7kfv H L 0 A protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B12 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.102 X-RAY DIFFRACTION 0.216 0.183 False True IGHV3 IGKV1 Kappa None None None None None 6wg1 H L 0 C peptide NA npna6 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab399 in complex with NPNA6 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 2.086 X-RAY DIFFRACTION 0.246 0.197 False True IGHV3 IGKV2 Kappa None None None None None 6ii9 M N 0 C protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L3A-44 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.5 X-RAY DIFFRACTION 0.234 0.201 False True IGHV4 IGLV1 Lambda 1.94e-08 -10.521320906302677 SPR TBD 1wc7 B A 0 A Hapten PP3 ALANYL-PYRIDOXAL-5'-PHOSPHATE ANTIBODY 11/09/04 FAB FRAGMENT OF PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH PHOSPHOPYRIDOXYL-L-ALANINE MUS MUSCULUS mus musculus mus musculus mus musculus PIMPANEAU, B.GOLINELLI-, CHRISTEN, P. 2.33 X-RAY DIFFRACTION unknown unknown False True IGHV7 IGKV4 Kappa None None None None None 6o2a A B 0 F peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein NDN and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.15 X-RAY DIFFRACTION 0.221 0.193 False True IGHV3 IGKV3 Kappa None None None None None 2vyr K NA 0 IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 6zwk C NA 0 I peptide NA histone h2ax IMMUNE SYSTEM 07/28/20 Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens McEwen, A.G., Moeglin, E., Desplancq, D., Weiss, E., Poterszman, A. 1.55 X-RAY DIFFRACTION 0.184 0.149 False True IGHV1 NA NA None None None None None 1lo3 H L 0 H Hapten AN1 3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID IMMUNE SYSTEM 05/06/02 Retro-Diels-Alderase Catalytic Antibody: Product Analogue MUS MUSCULUS mus musculus mus musculus mus musculus Hugot, M., Reymond, J.L., Baumann, U. 2.3 X-RAY DIFFRACTION 0.259 0.208 False False IGHV5 IGKV1 Kappa None None None None None 4xbp C D 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylethanolamine (06:0 PE) HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.94 X-RAY DIFFRACTION 0.271 0.228 False True IGHV1 IGKV3 Kappa None None None None None 7wr8 A B 0 R protein NA spike protein s1 VIRAL PROTEIN 01/26/22 Local CryoEM structure of the SARS-CoV-2 S6P(B.1.1.529) in complex with BD55-3152 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 2dqu H L 0 H Hapten CPD [1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL ESTER IMMUNE SYSTEM 05/30/06 Crystal form II: high resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog MUS MUSCULUS mus musculus mus musculus mus musculus Kristensen, O., Vassylyev, D.G., Tanaka, F., Ito, N., Morikawa, K., Fujii, I. 1.7 X-RAY DIFFRACTION 0.246 0.207 False False IGHV5 IGKV1 Kappa None None None None None 1z3g I M 0 B protein ookinete surface protein pvs25 IMMUNE SYSTEM/CELL ADHESION 03/12/05 Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8 MUS MUSCULUS; PLASMODIUM VIVAX SAI-1 mus musculus mus musculus plasmodium vivax sai-1 Saxena, A.K., Singh, K., Su, H.P., Klein, M.M., Stowers, A.W., Saul, A.J., Long, C.A., Garboczi, D.N. 3.3 X-RAY DIFFRACTION 0.327 0.272 False True IGHV1 IGKV4 Kappa None None None None None 5xqy NA E 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 3j70 R S 0 U protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/22/14 Model of gp120, including variable regions, in complex with CD4 and 17b HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Rasheed, M., Bettadapura, R., Bajaj, C. NOT ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 6xq4 E F 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S8V2-47 in complex with the influenza hemagglutinin head domain of A/Beijing/262/1995(H1N1) INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) McCarthy, K.R., Harrison, S.C. 3.347 X-RAY DIFFRACTION 0.279 0.238 False True IGHV3 IGKV4 Kappa None None None None None 5kvf H L 0 E protein zika envelope diii VIRAL PROTEIN/IMMUNE SYSTEM 07/14/16 Zika specific antibody, ZV-64, bound to ZIKA envelope DIII ZIKA VIRUS; MUS MUSCULUS mus musculus mus musculus zika virus Zhao, H., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 1.4 X-RAY DIFFRACTION 0.187 0.154 False False IGHV1 IGKV8 Kappa 3.2e-08 -10.224804843093384 SPR TBD 6fys B NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 1dql H L 0 IMMUNE SYSTEM 01/04/00 CRYSTAL STRUCTURE OF AN UNLIGANDED (NATIVE) FV FROM A HUMAN IGM ANTI-PEPTIDE ANTIBODY HOMO SAPIENS homo sapiens homo sapiens Ramsland, P.A., Shan, L., Moomaw, C.R., Slaughter, C.A., Guddat, L.W., Edmundson, A.B. 2.6 X-RAY DIFFRACTION 0.261 0.181 False False IGHV3 IGKV1 Kappa None None None None None 1igy D C 0 IMMUNOGLOBULIN 10/09/97 STRUCTURE OF IMMUNOGLOBULIN MUS MUSCULUS mus musculus mus musculus Harris, L.J., McPherson, A. 3.2 X-RAY DIFFRACTION 0.327 0.211 False False IGHV1 IGKV6 Kappa None None None None None 7qn8 L NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25 HOMO SAPIENS homo sapiens homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7jv4 H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (one RBD open) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV7 Lambda None None None None None 4kfz D NA 0 B protein lmo-2 TRANSCRIPTION 04/28/13 Crystal structure of LMO2 and anti-LMO2 VH complex HOMO SAPIENS homo sapiens homo sapiens Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H. 2.8 X-RAY DIFFRACTION 0.258 0.239 False True IGHV3 9.400000000000001e-08 -9.586368792768159 Unknown TBD 4gw4 H L 0 IMMUNE SYSTEM 08/31/12 Crystal structure of 3BNC60 Fab with P61A mutation HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Fu, B.Z., Bjorkman, P.J. 2.65 X-RAY DIFFRACTION 0.256 0.213 False True IGHV1 IGKV1 Kappa None None None None None 6mph H L 0 D protein envelope glycoprotein gp41 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 6o3g E F 0 G peptide meper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41). HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 3.645 X-RAY DIFFRACTION 0.289 0.260 False True IGHV1 IGKV3 Kappa None None None None None 7qu2 A B 0 C protein NA glycoprotein g1 IMMUNE SYSTEM 01/17/22 Junin virus GP1 glycoprotein in complex with Fab fragment of antibody JUN1 MUS MUSCULUS; ARGENTINIAN MAMMARENAVIRUS mus musculus mus musculus argentinian mammarenavirus Ng, W.M., Sahin, M., Krumm, S.A., Seow, J., Zeltina, A., Harlos, K., Paesen, G., Pinschewer, D.D., Doores, K.J., Bowden, T.A. 2.5 X-RAY DIFFRACTION 0.254 0.223 False True IGHV13 IGKV6 Kappa None None None None None 5ktz 7 NA 0 3 protein genome polyprotein VIRUS/immune system 07/12/16 expanded poliovirus in complex with VHH 12B CAMELUS DROMEDARIUS; POLIOVIRUS TYPE 1; POLIOVIRUS TYPE 1 (STRAIN MAHONEY) camelus dromedarius poliovirus type 1 Strauss, M., Schotte, L., Filman, D.J., Hogle, J.M. 4.3 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6fxn H I 0 C protein tumor necrosis factor ligand superfamily member 13b IMMUNE SYSTEM 03/09/18 Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lammens, A., Maskos, K., Willen, L., Jiang, X., Schneider, P. 2.9 X-RAY DIFFRACTION 0.231 0.191 False True IGHV1 IGLV3 Lambda None None None None None 5w9o H I 0 G protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.5 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 4wff E D 0 A protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a K+ bound nonconductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 2.5 X-RAY DIFFRACTION 0.245 0.213 False True IGHV1 IGKV4 Kappa None None None None None 7kxj J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/04/20 SARS-CoV-2 spike protein in complex with Fab 15033-7, 3-""up"", asymmetric SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J. 6.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3upa NA A 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 1.8 X-RAY DIFFRACTION 0.283 0.229 False True IGKV1 Kappa None None None None None 4hii D C 0 C carbohydrate GAL polysaccharide IMMUNE SYSTEM 10/11/12 Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound rhamnose-galactose HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S, Thomson, C.A., Schrader, J.W., Pai, E.F. 2.3 X-RAY DIFFRACTION 0.256 0.243 False True IGHV3 IGKV3 Kappa None None None None None 6z7w H G 0 O | P peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Human insulin in complex with the analytical antibody HUI-018 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.42 X-RAY DIFFRACTION 0.275 0.209 False True IGHV1 IGKV6 Kappa None None None None None 6vyv K O 0 E protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/27/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain ROSS RIVER VIRUS (STRAIN T48); HOMO SAPIENS homo sapiens homo sapiens ross river virus (strain t48) Miller, A.S., Kuhn, R.J. 6.33 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 4tnv G K 0 C protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False IGHV1 IGLV1 Lambda None None None None None 7kgk B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 10/16/20 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 2.6 X-RAY DIFFRACTION 0.276 0.258 False True IGHV1 NA NA None None None None None 7lfa H L 0 C protein NA apolipoprotein l1 IMMUNE SYSTEM 01/15/21 Fab 3B6 bound to ApoL1 NTD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Kirchhofer, D. 1.857 X-RAY DIFFRACTION 0.242 0.205 False True IGHV1 IGLV1 Lambda None None None None None 7ps5 H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-47 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.14 X-RAY DIFFRACTION 0.274 0.226 False True IGHV1 IGKV3 Kappa None None None None None 3wlw C D 0 A protein receptor tyrosine-protein kinase erbb-2 HYDROLASE/IMMUNE SYSTEM 11/15/13 Molecular Architecture of the ErbB2 Extracellular Domain Homodimer HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hu, S., Lou, Z.Y., Guo, Y.J. 3.088 X-RAY DIFFRACTION 0.269 0.232 False True IGHV1 IGLV2 Lambda None None None None None 1q9o B A 0 IMMUNE SYSTEM 08/25/03 S45-18 Fab Unliganded MUS MUSCULUS mus musculus mus musculus Nguyen, H.P., Seto, N.O., MacKenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.79 X-RAY DIFFRACTION 0.247 0.220 False False IGHV7 IGKV8 Kappa None None None None None 5ijv H L 0 IMMUNE SYSTEM 03/02/16 Crystal structure of bovine Fab E03 BOS TAURUS bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.247 0.204 False True IGHV1 IGLV1 Lambda None None None None None 4nm4 I M 0 immune system 11/14/13 Crystal structure of broadly neutralizing antibody CR8043 HOMO SAPIENS homo sapiens homo sapiens Lee, P.S., Wilson, I.A. 2.65 X-RAY DIFFRACTION 0.232 0.175 False False IGHV1 IGKV4 Kappa None None None None None 6orp J K 0 I protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 3whe 5 6 0 J protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 5mub L M 0 N peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 5e8d H L 0 A peptide proepiregulin IMMUNE SYSTEM 10/14/15 Crystal structure of human epiregulin in complex with the Fab fragment of murine monoclonal antibody 9E5 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kado, Y., Mizohata, E., Nagatoishi, S., Iijima, M., Shinoda, K., Miyafusa, T., Nakayama, T., Yoshizumi, T., Sugiyama, A., Kawamura, T., Lee, Y.H., Matsumura, H., Doi, H., Fujitani, H., Kodama, T., Shibasaki, Y., Tsumoto, K., Inoue, T. 2.5 X-RAY DIFFRACTION 0.263 0.190 False False IGHV14 IGKV19 Kappa 6.5e-09 -11.169184562689624 Unknown TBD 5i8h I J 0 A protein bg505 sosip.664 gp120 IMMUNE SYSTEM 02/18/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Zhou, T., Kwong, P.D. 4.301 X-RAY DIFFRACTION 0.309 0.281 False True IGHV4 IGLV3 Lambda None None None None None 6sni H L 0 X protein dolichyl pyrophosphate man9glcnac2 alpha-1,3-glucosyltransferase MEMBRANE PROTEIN 08/24/19 Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab SACCHAROMYCES CEREVISIAE; SYNTHETIC CONSTRUCT synthetic construct synthetic construct saccharomyces cerevisiae Bloch, J.S., Pesciullesi, G., Boilevin, J., Nosol, K., Irobalieva, R.N., Darbre, T., Aebi, M., Kossiakoff, A.A., Reymond, J.L., Locher, K.P. 3 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 3fo2 B A 0 A Hapten BZH 5-[(2-AMINO-1H-BENZIMIDAZOL-6-YL)AMINO]-5-OXOPENTANOIC ACID IMMUNE SYSTEM 12/27/08 Crystal structure of hapten complex of catalytic elimination antibody 13G5 (Glu(L39)Gln mutant) MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.18 X-RAY DIFFRACTION 0.256 0.201 False True IGHV2 IGKV1 Kappa None None None None None 7lex K L 0 M protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1fgn H L 0 IMMUNOGLOBULIN 04/10/97 MONOCLONAL MURINE ANTIBODY 5G9-ANTI-HUMAN TISSUE FACTOR MUS MUSCULUS mus musculus mus musculus Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.304 0.217 False False IGHV14 IGKV14 Kappa None None None None None 5ush H L 0 X protein imv membrane protein VIRAL PROTEIN/Immune system 02/13/17 Structure of vaccinia virus D8 protein bound to human Fab vv66 VACCINIA VIRUS; HOMO SAPIENS homo sapiens homo sapiens vaccinia virus Zajonc, D.M. 2.3 X-RAY DIFFRACTION 0.257 0.218 False False IGHV4 IGLV1 Lambda 1.5000000000000002e-09 -12.037965345328766 SPR TBD 5i8e A B 0 IMMUNE SYSTEM 02/18/16 Crystal Structure of Broadly Neutralizing HIV-1 Fusion Peptide-Targeting Antibody VRC34.01 Fab HOMO SAPIENS homo sapiens homo sapiens Xu, K., Zhou, T., Liu, K., Kwong, P.D. 2.655 X-RAY DIFFRACTION 0.248 0.186 False True IGHV1 IGKV1 Kappa None None None None None 6ubi A B 0 C peptide hiv fusion peptide 512-519 IMMUNE SYSTEM/VIRAL PROTEIN 09/11/19 N123-VRC34.05 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 1.903 X-RAY DIFFRACTION 0.288 0.237 False True unknown IGKV1 Kappa None None None None None 5ggu A B 0 IMMUNE SYSTEM 06/16/16 Crystal structure of tremelimumab Fab homo sapiens homo sapiens Heo, Y.S. 2.292 X-RAY DIFFRACTION 0.243 0.185 False True IGHV3 IGKV1 Kappa None None None None None 1ncw H L 0 IMMUNE SYSTEM 12/05/02 Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid MUS MUSCULUS mus musculus mus musculus Zhu, X., Wilson, I.A. 1.3 X-RAY DIFFRACTION unknown unknown False False IGHV3 IGKV1 Kappa None None None None None 4d9l J N 0 IMMUNE SYSTEM 01/11/12 Fab structure of anti-HIV-1 gp120 V2 mAb 697 HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.485 X-RAY DIFFRACTION 0.238 0.176 False True IGHV1 IGLV1 Lambda None None None None None 6vl9 A B 0 NA NA NA NA IMMUNE SYSTEM 01/23/20 Anti-PEG antibody 6-3 Fab fragment in complex with PEG MUS MUSCULUS mus musculus mus musculus Nicely, N.I., Huckaby, J.T., Lai, S.K., Jacobs, T.M. 2.63 X-RAY DIFFRACTION 0.250 0.178 False True IGHV9 IGKV8 Kappa None None None None None 6k2i A NA 4 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7sp6 C NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus hyaluronan synthase PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2; LAMA GLAMA lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1a6w H L 0 H Hapten NIP 4-HYDROXY-5-IODO-3-NITROPHENYLACETYL-EPSILON-AMINOCAPROIC ACID ANION IMMUNOGLOBULIN 03/03/98 B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-5-IODO-3-NITROPHENYL) ACETATE COMPOUND MUS MUSCULUS mus musculus mus musculus mus musculus Simon, T., Henrick, K., Hirshberg, M., Winter, G. 2.0 X-RAY DIFFRACTION unknown 0.171 False False IGHV1 IGLV1 Lambda None None None None None 3esu F f 0 IMMUNE SYSTEM 10/06/08 Crystal structure of anthrax-neutralizing single-chain antibody 14b7 MUS MUSCULUS mus musculus Monzingo, A.F., Maynard, J.A., Iverson, B.L., Georgiou, G., Robertus, J.D. 1.3 X-RAY DIFFRACTION 0.236 0.216 True True unknown unknown unknown None None None None None 6whk C B 0 A protein NA hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 04/08/20 Minimally mutated anti-influenza broadly neutralizing antibody INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) Bajic, G., Schmidt, A.G. 2.6 X-RAY DIFFRACTION 0.268 0.218 False True IGHV3 IGLV1 Lambda None None None None None 7lyw C D 0 NA NA NA NA IMMUNE SYSTEM 03/08/21 Crystal structure of the HCMV pentamer-specific antibody 2-25 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., Mishra, A.K., McLellan, J.S. 2.51 X-RAY DIFFRACTION 0.219 0.187 False True IGHV1 IGLV3 Lambda None None None None None 1qp1 NA C 0 IMMUNE SYSTEM 05/30/99 KAPPA VARIABLE LIGHT CHAIN HOMO SAPIENS homo sapiens Steinrauf, L.K. 2.06 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 6cnj G F 0 C protein NA neuronal acetylcholine receptor subunit beta-2 TRANSPORT PROTEIN 03/08/18 Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Walsh Jr, R.M., Roh, S.H., Gharpure, A., Morales-Perez, C.L., Teng, J., Hibbs, R.E. 3.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 1mex H L 0 H Hapten RAC 4-(2-DIMETHYLCARBAMOYL-PHENYLCARBAMOYLOXYMETHYL)-BENZOIC ACID IMMUNE SYSTEM 08/08/02 Antibody Catalysis of a Bimolecular Cycloaddition Reaction MUS MUSCULUS mus musculus mus musculus mus musculus Heine, A., Wilson, I.A. 1.25 X-RAY DIFFRACTION unknown unknown False False IGHV1 IGKV6 Kappa None None None None None 3u0w H L 0 IMMUNE SYSTEM 09/29/11 AD related murine antibody Fragment MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Miles, L.A., Crespi, G.A.N., Parker, M.W. 2.0 X-RAY DIFFRACTION 0.235 0.189 False True IGHV4 IGKV10 Kappa None None None None None 1dvf B A 0 COMPLEX (IDIOTOPE-ANTIIDIOTOPE) 04/13/96 IDIOTOPIC ANTIBODY D1.3 FV FRAGMENT-ANTIIDIOTOPIC ANTIBODY E5.2 FV FRAGMENT COMPLEX MUS MUSCULUS mus musculus mus musculus Braden, B.C., Fields, B.A., Ysern, X., Dall'Acqua, W., Goldbaum, F.A., Poljak, R.J., Mariuzza, R.A. 1.9 X-RAY DIFFRACTION 0.249 0.194 False True IGHV2 IGKV12 Kappa None None None None None 5esv C D 0 F protein 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase,envelope glycoprotein gp160 IMMUNE SYSTEM 11/17/15 Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade C Superinfecting Strain of Donor CAP256. HOMO SAPIENS; HAEMOPHILUS INFLUENZAE homo sapiens homo sapiens haemophilus influenzae, human immunodeficiencyvirus 1, haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd) Gorman, J., Yang, M., Kwong, P.D. 3.105 X-RAY DIFFRACTION 0.259 0.209 False True IGHV3 IGKV3 Kappa None None None None None 5tlk F E 0 Y protein cd27 antigen IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.7 X-RAY DIFFRACTION 0.263 0.213 False True IGHV1 IGKV3 Kappa None None None None None 7dst E NA 0 C protein NA vp3 of o type fmdv capsid VIRUS 01/02/21 FMDV capsid in complex with M170 Nab LAMA GLAMA; FOOT-AND-MOUTH DISEASE VIRUS lama glama foot-and-mouth disease virus Dong, H., Liu, P. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7sq1 A I 0 G protein NA envelope glycoprotein gp160 Viral Protein/Immune System 11/04/21 BG505.MD39TS Env trimer in complex with Fab from antibody C05 Human immunodeficiency virus 1; Mus musculus mus musculus mus musculus human immunodeficiency virus 1 Moore, A., Du, J., Xu, Z., Walker, S., Kulp, D.W., Pallesen, J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV3 Kappa None None None None None 7t0r H L 0 A protein NA t-cell surface glycoprotein cd4 ANTIVIRAL PROTEIN 11/30/21 Crystal structure of the anti-CD4 adnectin 6940_B01 as a complex with the extracellular domains of CD4 and ibalizumab fAb MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Williams, S.P., Concha, N.O., Wensel, D.L., Hong, X. 3.65 X-RAY DIFFRACTION 0.292 0.226 False True IGHV1 IGKV4 Kappa None None None None None 3t0w NA B 0 A Hapten DIW 1-(3-SULFOPROPYL)-4-[(1E,3E)-3-(1,3,3-TRIMETHYL-1,3-DIHYDRO-2H-INDOL-2-YLIDENE)PROP-1-EN-1-YL]QUINOLINIUM DYE-BINDING PROTEIN 07/20/11 Fluorogen activating protein M8VL in complex with dimethylindole red HOMO SAPIENS homo sapiens homo sapiens Stanfield, R., Senutovitch, N., Bhattacharyya, S., Rule, G., Wilson, I.A., Armitage, B., Waggoner, A.S., Berget, P. 1.501 X-RAY DIFFRACTION 0.183 0.148 False True IGLV1 Lambda 5.0000000000000004e-08 -9.960387018191561 Unknown TBD 7wuj S s 0 A | B protein | protein NA | NA mini-gs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/08/22 Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 HOMO SAPIENS; PSYCHROMONAS SP. B3M02; SYNTHETIC CONSTRUCT; LAMA GLAMA synthetic construct homo sapiens | homo sapiens Guo, S.C., Huang, S.M., He, Q.T., Xiao, P., Sun, J.P., Yu, X. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4fqy H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody CR9114 bound to H3 influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Ekiert, D.C., Dreyfus, C., Wilson, I.A. 5.253 X-RAY DIFFRACTION 0.374 0.366 False True IGHV1 IGLV1 Lambda 2.2000000000000003e-09 -11.81104868630058 BLI TBD 7r8a C D 0 B | A protein | protein NA | NA atp-binding cassette sub-family g member 8 | atp-binding cassette sub-family g member 5 LIPID TRANSPORT 06/26/21 The structure of human ABCG5/ABCG8 purified from mammalian cells HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Sun, Y., Li, X., Long, T. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV9 Kappa None None None None None 3fb5 A B 0 C protein voltage-gated potassium channel membrane protein/metal transport 11/18/08 KcsA potassium channel in the partially open state with 14.5 A opening at T112 STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 2.8 X-RAY DIFFRACTION 0.252 0.243 False False IGHV1 IGKV5 Kappa None None None None None 6o3j H L 0 G peptide mper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41) and phosphatidic acid (06:0 PA) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 3.416 X-RAY DIFFRACTION 0.265 0.215 False True IGHV1 IGKV3 Kappa None None None None None 5h32 I M 0 C protein structural protein e VIRUS/IMMUNE SYSTEM 10/20/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lok, S.-M. 12 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7tm0 G F 0 B protein NA spike glycoprotein VIRUS 01/19/22 SARS-CoV-2 S B.1.1.529 Omicron variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1jnh H G 0 H Hapten ECO ESTRADIOL-6 CARBOXYL-METHYL-OXIME IMMUNE SYSTEM 07/24/01 Crystal Structure of Fab-Estradiol Complexes MUS MUSCULUS mus musculus mus musculus mus musculus Monnet, C., Bettsworth, F., Stura, E.A., Le Du, M.-H., Menez, R., Derrien, L., Zinn-Justin, S., Gilquin, B., Sibai, G., Battail-Poirot, N., Jolivet, M., Menez, A., Arnaud, M., Ducancel, F., Charbonnier, J.B. 2.85 X-RAY DIFFRACTION 0.253 0.198 False False IGHV1 IGLV1 Lambda None None None None None 6oyh E NA 0 A protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/14/19 Crystal structure of MraY bound to carbacaprazamycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 2.95 X-RAY DIFFRACTION 0.268 0.249 False True IGHV1 None None None None None 5j3d H L 0 K | J protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 IMMUNE SYSTEM 03/30/16 Crystal structure of human Fab 14N4 in complex with post-fusion RSV F HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A homo sapiens homo sapiens human respiratory syncytial virus a | human respiratory syncytial virus a Mousa, J.J., Crowe, J.E. 4.077 X-RAY DIFFRACTION 0.282 0.257 False True IGHV3 IGKV1 Kappa None None None None None 1mel B NA 0 M protein NA lysozyme COMPLEX (ANTIBODY/ANTIGEN) 06/06/96 CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Desmyter, A., Transue, T.R., Arbabi Gharoudi, M., Dao Thi, M., Poortmans, F., Hamers, R., Muyldermans, S., Wyns, L. 2.5 X-RAY DIFFRACTION 0.323 0.221 False True IGHV1 NA NA None None None None None 7k76 H L 0 P peptide NA pfcsp n-terminal peptide p17 IMMUNE SYSTEM 09/22/20 Crystal structure of MAD2-6 IgG Fab in complex with PfCSP N-terminal peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Wilson, I.A. 2.14 X-RAY DIFFRACTION 0.218 0.184 False True IGHV4 IGKV1 Kappa None None None None None 6pzf F E 0 B protein neuraminidase IMMUNE SYSTEM 07/31/19 Crystal structure of human NA-63 Fab in complex with neuraminidase from A/Hunan/02650/2016(H7N9) INFLUENZA A VIRUS (A/HUNAN/02650/2016(H7N9); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/hunan/02650/2016(h7n9) Zhu, X., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV1 Kappa None None None None None 7mub A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 05/14/21 KcsA Open gate E71V mutant in Potassium SYNTHETIC CONSTRUCT; STREPTOMYCES LIVIDANS synthetic construct synthetic construct streptomyces lividans Rohaim, A., Li, J., Weingarth, M., Roux, B. 3.0 X-RAY DIFFRACTION 0.260 0.197 False True IGHV3 IGKV1 Kappa None None None None None 5mo9 H L 0 X protein bdnf/nt-3 growth factors receptor IMMUNE SYSTEM 12/14/16 Structure of human TrkB receptor ligand binding domain in complex with the Fab frgment of antibody AB20 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Hoerer, S. 2.594 X-RAY DIFFRACTION 0.224 0.190 False True IGHV1 IGKV1 Kappa None None None None None 2ltq C B 0 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 7lcn H L 0 C protein NA spike glycoprotein IMMUNE SYSTEM 01/11/21 Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1050.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 4k3d I M 0 IMMUNE SYSTEM 04/10/13 Crystal structure of bovine antibody BLV1H12 with ultralong CDR H3 BOS TAURUS bos taurus bos taurus Ekiert, D.C., Wang, F., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.210 0.182 False True IGHV1 IGLV1 Lambda None None None None None 6oan B b 0 A protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 053054 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 2.9 X-RAY DIFFRACTION 0.252 0.230 True True unknown unknown unknown None None None None None 6qup B NA 0 A protein NA lysm type receptor kinase PLANT PROTEIN 02/28/19 Crystal structure of EPR3 ectodomain LOTUS JAPONICUS; LAMA GLAMA lama glama lotus japonicus Wong, J.E., Gysel, K., Birkefeldt, T.G., Vinther, M., Muszynski, A., Azadi, P., Laursen, N.S., Sullivan, J.T., Ronson, C.W., Stougaard, J., Andersen, K.R. 1.871 X-RAY DIFFRACTION 0.210 0.163 False True IGHV1 NA NA None None None None None 4nkd E F 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.303 X-RAY DIFFRACTION 0.231 0.195 False True IGHV1 IGKV1 Kappa None None None None None 7v2a E D 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/07/21 SARS-CoV-2 Spike trimer in complex with XG014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, K., Wang, X., Pan, L. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 5f3h G H 0 K protein growth/differentiation factor 8 Signaling Protein/Immune System 12/02/15 Structure of myostatin in complex with humanized RK35 antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Parris, K.D., Mosyak, L. 2.7 X-RAY DIFFRACTION 0.270 0.218 False True IGHV3 IGKV1 Kappa None None None None None 7jv4 D E 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (one RBD open) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV7 Lambda None None None None None 5yd3 G g 0 H peptide epitope peptide IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.184 0.136 True True unknown unknown unknown None None None None None 3kj4 H L 0 A protein reticulon-4 receptor IMMUNE SYSTEM 11/02/09 Structure of rat Nogo receptor bound to 1D9 antagonist antibody RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Silvian, L.F. 3.1 X-RAY DIFFRACTION 0.318 0.253 False True IGHV2 IGKV8 Kappa None None None None None 5hvh B NA 0 A protein carboxypeptidase b2 HYDROLASE/HYDROLASE INHIBITOR 01/28/16 Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 3.0 X-RAY DIFFRACTION 0.202 0.190 False True IGHV1 None None None None None 2kqm NA B 9 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6dlb H L 0 IMMUNE SYSTEM 05/31/18 Crystal Structure of an influenza A hemagglutinin antibody Fab CH65:1203d4 chimera HOMO SAPIENS homo sapiens homo sapiens Dong, J., Finn, J.A., Crowe, J.E. 2.2 X-RAY DIFFRACTION 0.222 0.190 False True IGHV1 IGLV3 Lambda None None None None None 1rzf H L 0 IMMUNE SYSTEM 12/24/03 Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51 HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.232 0.198 False True IGHV1 IGLV1 Lambda None None None None None 5id0 D C 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with aminoheptanoic acid-linked meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.208 0.160 False True IGHV2 IGKV5 Kappa 1.7e-06 -7.871075957560247 Unknown TBD 1b6d NA A 0 IMMUNOGLOBULIN 01/13/99 BENCE JONES PROTEIN DEL: AN ENTIRE IMMUNOGLOBULIN KAPPA LIGHT-CHAIN DIMER HOMO SAPIENS homo sapiens Roussel, A., Spinelli, S., Deret, S., Aucouturier, P., Cambillau, C. 2.74 X-RAY DIFFRACTION 0.265 0.207 False False IGKV1 Kappa None None None None None 7tee H L 0 D protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 Non-active2-like RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Furukawa, H. 6.59 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV19 Kappa None None None None None 3fku X x 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/17/08 Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens influenza a virus | influenza a virus Hwang, W.C., Santelli, E., Stec, B., Wei, G., Cadwell, G., Bankston, L.A., Sui, J., Perez, S., Aird, D., Chen, L.M., Ali, M., Murakami, A., Yammanuru, A., Han, T., Cox, N., Donis, R.O., Liddington, R.C., Marasco, W.A. 3.2 X-RAY DIFFRACTION 0.286 0.232 True True unknown unknown unknown 1.30E-10 -13.48 SPR 25 19234466 6k6a NA A 0 D protein engineered protein a STRUCTURAL PROTEIN 06/02/19 Application of anti-helix antibodies in protein structure determination (8188cys-3LRHcys) HOMO SAPIENS; STAPHYLOCOCCUS AUREUS homo sapiens staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.94 X-RAY DIFFRACTION 0.215 0.169 False True IGLV1 Lambda None None None None None 4org A B 0 IMMUNE SYSTEM 02/11/14 Crystal structure of human Fab CAP256-VRC26.04, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 3.121 X-RAY DIFFRACTION 0.289 0.275 False True IGHV3 IGLV1 Lambda None None None None None 1tzg I M 0 Q peptide envelope polyprotein gp160 IMMUNE SYSTEM 07/09/04 Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Zwick, M.B., Stanfield, R.L., Kunert, R., Binley, J.M., Katinger, H., Burton, D.R., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.260 0.217 False True IGHV1 IGKV3 Kappa None None None None None 5f7k D NA 0 B protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with Nanobody Nb-ER19 HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.17 X-RAY DIFFRACTION 0.207 0.171 False True IGHV1 None None None None None 6ute G H 0 VIRAL PROTEIN 10/29/19 Crystal structure of Z032 Fab in complex with WNV EDIII HOMO SAPIENS; WEST NILE VIRUS homo sapiens homo sapiens Esswein, S.R., Gristick, H.B., Keeffe, J.R., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 6y1m H L 0 L Hapten DEP DIETHYL PHOSPHONATE IMMUNE SYSTEM 02/12/20 Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - L47K mutant HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chatziefthimiou, S., Mokrushina, Y., Smirnov, I., Gabibov, A., Wilmanns, M. 2.0 X-RAY DIFFRACTION 0.230 0.182 False True IGHV4 IGLV1 Lambda None None None None None 7kqb H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/14/20 SARS-CoV-2 spike glycoprotein:Fab 5A6 complex I SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Asarnow, D., Charles, C., Cheng, Y. 2.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7xod R NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/01/22 SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA homo sapiens severe acute respiratory syndrome coronavirus2 Xu, Y., Wu, C., Liu, H., Yin, W., Xu, H.E. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6vmk i h 0 j protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False False IGHV1 IGKV1 Kappa None None None None None 7tzg A a 0 D protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 02/15/22 LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition HOMO SAPIENS homo sapiens homo sapiens Ming, Q., Tran, T.H., Luca, V.C. 3.71 X-RAY DIFFRACTION 0.275 0.226 True True unknown unknown unknown None None None None None 1lgv NA B 0 IMMUNE SYSTEM 04/16/02 Structure of a Human Bence-Jones Dimer Crystallized in U.S. Space Shuttle Mission STS-95: 100K HOMO SAPIENS homo sapiens Terzyan, S.S., DeWitt, C.R., Ramsland, P.A., Bourne, P.C., Edmundson, A.B. 1.95 X-RAY DIFFRACTION 0.245 0.200 False False IGLV2 Lambda None None None None None 6nqd C D 0 B | A protein | protein NA | NA t/f100 env gp41 | t/f100 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/21/19 Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Fang, Q., Rossmann, M.G. 3.9 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7or9 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and COVOX-278 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.34 X-RAY DIFFRACTION 0.230 0.194 False True IGHV1 IGKV1 Kappa None None None None None 43c9 H G 0 IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY MUS MUSCULUS mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.2 X-RAY DIFFRACTION 0.265 0.210 False True IGHV2 IGKV8 Kappa None None None None None 5ado H L 0 L Hapten DEP DIETHYL PHOSPHONATE 08/21/15 Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - Light chain S35R mutant HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chatziefthimiou, S.D., Smirnov, I.V., Golovin, A.V., Stepanova, A.V., Peng, Y., Zolotareva, O.I., Belogurov, A.A., Ponomarenko, N.A., Blackburn, G.M., Gabibov, A.A., Lerner, R., Wilmanns, M. 1.55 X-RAY DIFFRACTION 0.199 0.168 False True IGHV4 IGLV1 Lambda None None None None None 5t4z A B 0 IMMUNE SYSTEM 08/30/16 STRUCTURE OF THE ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 WITH FREE MAN9 GLYCAN MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I., Haynes, B.F. 1.991 X-RAY DIFFRACTION 0.239 0.187 False True IGHV2 IGLV1 Lambda None None None None None 1ieh A NA 8 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 5t3z D E 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/26/16 3.5 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gristick, H.B., Bjorkman, P.J. 3.5 X-RAY DIFFRACTION 0.298 0.275 False True IGHV1 IGLV2 Lambda None None None None None 7pgb f g 0 e protein NA unknown MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False False IGHV3 IGKV1 Kappa None None None None None 5w9p F G 0 J protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7kfy H L 0 A protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-F10 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.157 X-RAY DIFFRACTION 0.249 0.205 False True IGHV3 IGKV1 Kappa None None None None None 7bnv H L 0 A protein NA surface glycoprotein VIRAL PROTEIN 01/22/21 Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-300 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hall, G., Cowan, R., Carr, M. 2.35 X-RAY DIFFRACTION 0.265 0.224 False True IGHV5 IGKV3 Kappa None None None None None 1xgq B A 0 C protein lysozyme c IMMUNE SYSTEM 09/17/04 Structure for antibody HyHEL-63 Y33V mutant complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Li, Y., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.277 0.235 False True IGHV3 IGKV5 Kappa None None None None None 3l7f E D 0 IMMUNE SYSTEM 12/28/09 Structure of IL-13 antibody H2L6, A humanized variant OF C836 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.6 X-RAY DIFFRACTION 0.243 0.205 False True IGHV2 IGKV3 Kappa None None None None None 2fjf X W 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 2c1o B A 0 IMMUNE SYSTEM 09/19/05 ENAIIHis Fab fragment in the free form MUS MUSCULUS mus musculus mus musculus Parkkinen, T., Nevanen, T., Koivula, A., Rouvinen, J. 2.75 X-RAY DIFFRACTION 0.3011 0.2184 False True IGHV1 IGKV1 Kappa None None None None None 1qle H L 0 B protein cytochrome c oxidase polypeptide ii OXIDOREDUCTASE/IMMUNE SYSTEM 08/30/99 CRYO-STRUCTURE OF THE PARACOCCUS DENITRIFICANS FOUR-SUBUNIT CYTOCHROME C OXIDASE IN THE COMPLETELY OXIDIZED STATE COMPLEXED WITH AN ANTIBODY FV FRAGMENT MUS MUSCULUS; PARACOCCUS DENITRIFICANS mus musculus mus musculus paracoccus denitrificans Harrenga, A., Michel, H. 3.0 X-RAY DIFFRACTION 0.309 0.235 False True IGHV5 IGKV12 Kappa None None None None None 5cjs F E 0 K | J protein | protein NA | NA designed influenza hemagglutinin stem #4454, ha2 | designed influenza hemagglutinin stem #4454, ha1 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 Crystal structure of a monomeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct | synthetic construct Zhu, X., Wilson, I.A. 4.3 X-RAY DIFFRACTION 0.303 0.262 False True IGHV1 IGLV1 Lambda None None None None None 6ws6 A B 0 A Hapten JEF JEFFAMINE IMMUNE SYSTEM 05/27/20 Structural and functional analysis of a potent sarbecovirus neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., Marco, A.D., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Telenti, A., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 IGKV3 Kappa None None None None None 5i5k H L 0 B protein complement c5 IMMUNE SYSTEM 02/15/16 Structure of complement C5 in complex with eculizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schatz-Jakobsen, J.A., Andersen, G.R. 4.2 X-RAY DIFFRACTION 0.244 0.205 False True IGHV1 IGKV1 Kappa 1.7600000000000003e-11 -14.671745777572001 SPR TBD 5i8k H L 0 IMMUNE SYSTEM 02/19/16 HHH1 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Andersen, G.R., Spillner, E. 1.771 X-RAY DIFFRACTION 0.212 0.183 False True IGHV1 IGKV1 Kappa None None None None None 6ffj G g 0 ANTITUMOR PROTEIN 01/08/18 Anti-tumor antibody 14F7-derived single chain fragment variable (scFv) HOMO SAPIENS homo sapiens Bjerregaard-Andersen, K., Heggelund, J.E., Krengel, U. 2.2 X-RAY DIFFRACTION 0.238 0.184 True True unknown unknown unknown None None None None None 4c58 B NA 0 A protein cyclin-g-associated kinase TRANSFERASE 09/10/13 Structure of GAK kinase in complex with nanobody (NbGAK_4) HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S. 2.16 X-RAY DIFFRACTION 0.24172 0.17929 False False IGHV1 None None None None None 1kb5 H L 0 A | B protein | protein NA | NA kb5-c20 t-cell antigen receptor | kb5-c20 t-cell antigen receptor COMPLEX (IMMUNOGLOBULIN/RECEPTOR) 04/06/97 MURINE T-CELL RECEPTOR VARIABLE DOMAIN/FAB COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus | mus musculus Housset, D., Mazza, G., Gregoire, C., Piras, C., Malissen, B., Fontecilla-Camps, J.C. 2.5 X-RAY DIFFRACTION unknown 0.219 False False IGHV1 IGKV12 Kappa None None None None None 6osy R S 0 Q protein bg505 gp41 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True IGHV4 IGKV1 Kappa None None None None None 6wkl A B 0 NA NA NA NA IMMUNE SYSTEM 04/16/20 Fab Fragment of Anti-human LAG3 antibody (BAP050) MUS MUSCULUS mus musculus mus musculus Agnihotri, P., Mishra, A.K., Mariuzza, R.A. 1.89 X-RAY DIFFRACTION 0.223 0.193 False True IGHV9 IGKV10 Kappa None None None None None 7rku J K 0 B | C protein | protein NA | NA spike protein s1 | spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Jette, C.A., Bjorkman, P.J., Barnes, C.O. 3.2 X-RAY DIFFRACTION 0.231 0.188 False True IGHV4 IGKV1 Kappa None None None None None 6x04 H NA 0 G protein NA nucleoporin nup133 STRUCTURAL PROTEIN 05/15/20 Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN5 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 2.68 X-RAY DIFFRACTION 0.261 0.244 False True IGHV1 NA NA None None None None None 5o04 C NA 0 A protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 norovirus protruding domain in complex with Nanobody Nano-26 and Nano-85 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, A.D. 2.3 X-RAY DIFFRACTION 0.242 0.212 False True IGHV1 None None None None None 7dc7 A B 0 NA NA NA NA IMMUNE SYSTEM 10/23/20 Crystal structure of D12 Fab-ATP complex HOMO SAPIENS homo sapiens homo sapiens Kawauchi, H., Fukami, T.A., Tatsumi, K., Torizawa, T., Mimoto, F. 1.77 X-RAY DIFFRACTION 0.220 0.177 False True IGHV3 IGLV2 Lambda None None None None None 6gjq F NA 0 E protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/16/18 human NBD1 of CFTR in complex with nanobody T27 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.49 X-RAY DIFFRACTION 0.240 0.199 False True IGHV1 None None None None None 5w1k I H 0 J protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV4 IGKV3 Kappa None None None None None 2gki B b 0 IMMUNE SYSTEM 04/02/06 Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity MUS MUSCULUS mus musculus Kim, Y.R., Kim, J.S., Lee, S.H., Lee, W.R., Sohn, J.N., Chung, Y.C., Shim, H.K., Lee, S.C., Kwon, M.H., Kim, Y.S. 2.88 X-RAY DIFFRACTION 0.242 0.212 True True unknown unknown unknown None None None None None 4kq3 H L 0 IMMUNE SYSTEM 05/14/13 Crystal structure of Anti-IL-17A antibody CNTO3186 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 1.92 X-RAY DIFFRACTION 0.225 0.171 False True IGHV1 IGKV1 Kappa None None None None None 7ki0 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 10/22/20 Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Zhang, X., Belousoff, M.J., Danev, R., Sexton, P.M., Wootten, D. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1lo0 Y X 0 Y Hapten BC1 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID IMMUNE SYSTEM 05/05/02 Catalytic Retro-Diels-Alderase Transition State Analogue Complex MUS MUSCULUS mus musculus mus musculus mus musculus Hugot, M., Reymond, J.L., Baumann, U. 2.0 X-RAY DIFFRACTION 0.255 0.206 False False IGHV5 IGKV1 Kappa None None None None None 1nc2 B A 0 B Hapten DOE (S)-2-(4-(2-(2-HYDROXYETHYLTHIO)-ACETAMIDO)-BENZYL)-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETATE Immune system 12/04/02 Crystal Structure of Monoclonal Antibody 2D12.5 Fab Complexed with Y-DOTA MUS MUSCULUS mus musculus mus musculus mus musculus Corneillie, T.M., Fisher, A.J., Meares, C.F. 2.1 X-RAY DIFFRACTION 0.247 0.209 False False IGHV2 IGLV1 Lambda None None None None None 7luc L M 0 B protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/22/21 Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B RESPIRATORY SYNCYTIAL VIRUS; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus Wrapp, D., McLellan, J.S. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 4ksd B NA 0 A protein multidrug resistance protein 1a MEMBRANE PROTEIN, TRANSPORT PROTEIN 05/17/13 Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Ward, A., Szewczyk, P., Grimard, V., Lee, C-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G. 4.1001 X-RAY DIFFRACTION 0.344 0.323 False True IGHV1 None None None None None 6cxc X Y 0 D | C protein | protein NA | NA fusion glycoprotein f0, envelope glycoprotein chimera | fusion glycoprotein f0, envelope glycoprotein chimera VIRAL PROTEIN/IMMUNE SYSTEM 04/02/18 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus fusion protein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN IMMUNODEFICIENCY VIRUS 1 mus musculus mus musculus human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 | human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Xie, Q., Wang, Z., Chen, X., Ni, F., Ma, J., Wang, Q. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4qkx B NA 0 A protein beta-2 adrenergic receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 06/10/14 Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Weichert, D., Kruse, A.C., Manglik, A., Hiller, C., Zhang, C., Huebner, H., Kobilka, B.K., Gmeiner, P. 3.3 X-RAY DIFFRACTION 0.280 0.236 False True IGHV1 None None None None None 6dbe B NA 0 IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R330 LAMA GLAMA lama glama Brooks, C.L., Toride King, M., Huh, I. 1.65 X-RAY DIFFRACTION 0.223 0.185 False True IGHV1 None None None None None 7kfb I L 0 C protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442 EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5xhv H L 0 E protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 04/24/17 Crystal Structure Of Fab S40 In Complex With Influenza Hemagglutinin, HA1 subunit. INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Lee, C.C., Wang, A.H.J., Yu, C.M., Yang, A.S. 3.35 X-RAY DIFFRACTION 0.275 0.230 False True IGHV3 IGKV1 Kappa None None None None None 5v7j D E 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/20/17 Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Four Glycans (N197, N276, N362, and N462) removed in Complex with Neutralizing Antibodies 3H+109L and 35O22. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Stewart-Jones, G.B.E., Zhou, T., Kwong, P.D. 2.907 X-RAY DIFFRACTION 0.339 0.316 False True unknown unknown unknown None None None None None 3piq A B 0 IMMUNE SYSTEM 11/07/10 Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1 HOMO SAPIENS homo sapiens homo sapiens Changela, A., Gorny, M.K., Zolla-Pazner, S., Kwong, P.D. 3.325 X-RAY DIFFRACTION 0.299 0.236 False True IGHV3 IGLV3 Lambda None None None None None 7u0c A B 0 NA NA NA NA ANTIVIRAL PROTEIN,IMMUNE SYSTEM 02/17/22 Crystal structure of broadly neutralizing antibody HEPC3.4 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 3.3 X-RAY DIFFRACTION 0.260 0.215 False True IGHV1 IGKV1 Kappa None None None None None 7k7r E D 0 F peptide NA ebna1 peptide aa386-405 IMMUNE SYSTEM 09/23/20 EBNA1 peptide AA386-405 with Fab MS39p2w174 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human gammaherpesvirus 4 Lanz, T.V., Robinson, W.H., Jude, K.M. 2.5 X-RAY DIFFRACTION 0.252 0.211 False True IGHV3 IGKV2 Kappa None None None None None 6fpv A NA 0 IMMUNE SYSTEM 02/12/18 A llama-derived JBP1-targeting nanobody LAMA GLAMA lama glama van Beusekom, B., Adamopoulos, A., Heidebrecht, T., Joosten, R.P., Perrakis, A. 1.64 X-RAY DIFFRACTION 0.195 0.163 False True IGHV1 None None None None None 3chn A L 3 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 2kh2 B b 31 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7rxj A B 0 G protein NA circumsporozoite protein IMMUNE SYSTEM 08/23/21 Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 2.345 X-RAY DIFFRACTION 0.249 0.218 False True IGHV3 IGLV3 Lambda None None None None None 4i0c C NA 0 B protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 11/16/12 The structure of the camelid antibody cAbHuL5 in complex with human lysozyme HOMO SAPIENS; CAMELUS DROMEDARIUS camelus dromedarius homo sapiens De Genst, E., Chan, P.H., Pardon, E., Kumita, J.R., Christodoulou, J., Menzer, L., Chirgadze, D.Y., Robinson, C.V., Muyldermans, S., Matagne, A., Wyns, L., Dobson, C.M., Dumoulin, M. 1.95 X-RAY DIFFRACTION 0.219 0.187 False True IGHV1 NA NA None None None None None 4dk6 B NA 0 C protein rna-editing complex protein mp81 RNA BINDING PROTEIN/IMMUNE SYSTEM 02/03/12 Structure of Editosome protein LAMA GLAMA; TRYPANOSOMA BRUCEI lama trypanosoma brucei Park, Y.-J., Hol, W. 2.65 X-RAY DIFFRACTION 0.264 0.224 False True IGHV1 None None None None None 7raq H L 0 P peptide NA spike stem helix peptide IMMUNE SYSTEM 07/02/21 Crystal structure of CV3-25 Fab bound to SARS-CoV-2 spike stem helix peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hurlburt, N.K., Pancera, M. 1.74 X-RAY DIFFRACTION 0.203 0.181 False True IGHV5 IGKV1 Kappa None None None None None 6oc3 C D 0 E protein hemagglutinin IMMUNE SYSTEM 03/21/19 Crystal structure of FluA-20 Fab in complex with the head domain of H1 (A/Solomon Islands/3/2006) HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Wilson, I.A., Lang, S. 2.85 X-RAY DIFFRACTION 0.257 0.237 False True IGHV4 IGKV1 Kappa None None None None None 7r6w A B 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/23/21 SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2X35 Fab and S309 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Hernandez, P., Nix, J.C., Croll, T.I., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 1.83 X-RAY DIFFRACTION 0.232 0.211 False True IGHV1 IGKV3 Kappa None None None None None 7z1a D NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.59 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 6x3v K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 5nph H L 0 A peptide genome polyprotein IMMUNE SYSTEM 04/16/17 Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the Fab fragment of the non-neutralizing antibody DAO5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Vasiliauskaite, I., Rey, F.A., Krey, T. 1.7 X-RAY DIFFRACTION 0.203 0.179 False True IGHV1 IGKV5 Kappa None None None None None 7ly2 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2M28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7xic K L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/22 S-ECD (Omicron) in complex with STS165 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Y.N., Shen, Y.P., Zhang, Y.Y., Yan, R.H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7ckx N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 CELL CYCLE 07/20/20 Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens | homo sapiens Yan, W., Shao, Z. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4mhj W V 0 S protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 6.98 X-RAY DIFFRACTION 0.387 0.377 False True IGHV1 IGKV3 Kappa 1e-09 -12.27819680469229 BLI TBD 2kh2 B b 25 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 4nko F E 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.496 X-RAY DIFFRACTION 0.344 0.308 False True IGHV1 IGKV1 Kappa None None None None None 4n1c NA A 0 C protein lysozyme c Immune system/Hydrolase 10/03/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Roome, B., Stock, D., Christ, D. 1.7 X-RAY DIFFRACTION 0.233 0.197 False True IGKV1 Kappa None None None None None 6wgj G H 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.9 X-RAY DIFFRACTION 0.289 0.235 False True IGHV3 IGKV2 Kappa None None None None None 6x9x A NA 0 NA NA NA NA ANTIVIRAL PROTEIN, IMMUNE SYSTEM 06/03/20 Crystal structure of Fab fragment of Anti-HCV E2 antibody (HC84.26) HOMO SAPIENS homo sapiens Shahid, S., Mariuzza, R.A. 1.8 X-RAY DIFFRACTION 0.210 0.178 False True IGHV1 NA NA None None None None None 7qny H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 12/23/21 The receptor binding domain of SARS-CoV-2 spike glycoprotein in complex with COVOX-58 and COVOX-158 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.84 X-RAY DIFFRACTION 0.278 0.226 False True IGHV3 IGKV1 Kappa None None None None None 4fqv H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody CR9114 bound to H7 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Ekiert, D.C., Dreyfus, C., Wilson, I.A. 5.75 X-RAY DIFFRACTION 0.339 0.314 False True IGHV1 IGLV1 Lambda 1.1000000000000001e-09 -12.22172707862036 BLI TBD 4kte H L 0 IMMUNE SYSTEM 05/20/13 Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE148, from non-human primate MACACA MULATTA macaca mulatta macaca mulatta Poulsen, C., Tran, K., Stanfield, R., Wyatt, R.T. 1.8 X-RAY DIFFRACTION 0.194 0.165 False True IGHV4 IGLV5 Lambda None None None None None 3ixt H L 0 P peptide fusion glycoprotein f1 IMMUNE SYSTEM 09/04/09 Crystal Structure of Motavizumab Fab Bound to Peptide Epitope MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS mus musculus mus musculus human respiratory syncytial virus McLellan, J.S., Chen, M., Kim, A., Yang, Y., Graham, B.S., Kwong, P.D. 2.75 X-RAY DIFFRACTION 0.274 0.213 False True IGHV2 IGKV1 Kappa 2.41e-07 -9.02 SPR 20098425 6ss6 H L 0 A protein NA unknown PROTEIN BINDING 09/06/19 Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 3.25 X-RAY DIFFRACTION 0.361 0.300 False False IGHV3 IGLV1 Lambda None None None None None 7zfb C D 0 F protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.08 X-RAY DIFFRACTION 0.308 0.261 False True IGHV1 IGLV1 Lambda None None None None None 2osl H L 0 P peptide b-lymphocyte antigen cd20 Immune System 02/06/07 Crystal structure of Rituximab Fab in complex with an epitope peptide HOMO SAPIENS, MUS MUSCULUS; SYNTHETIC CONSTRUCT homo sapiens, mus musculus homo sapiens, mus musculus Du, J., Zhong, C., Ding, J. 2.6 X-RAY DIFFRACTION 0.296 0.239 False True IGHV1 IGKV4 Kappa None None None None None 3wlw H L 0 B protein receptor tyrosine-protein kinase erbb-2 HYDROLASE/IMMUNE SYSTEM 11/15/13 Molecular Architecture of the ErbB2 Extracellular Domain Homodimer HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hu, S., Lou, Z.Y., Guo, Y.J. 3.088 X-RAY DIFFRACTION 0.269 0.232 False True IGHV1 IGLV2 Lambda None None None None None 7kx4 B C 0 NA NA NA NA IMMUNE SYSTEM 12/03/20 Anti-CCHFV ADI-36121 Fab HOMO SAPIENS homo sapiens homo sapiens Mishra, A.K., McLellan, J.S. 2.6 X-RAY DIFFRACTION 0.239 0.198 False True IGHV3 IGKV1 Kappa None None None None None 7t6b E e 0 A | C protein | protein NA | NA guanine nucleotide-binding protein subunit alpha-13 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 12/13/21 Structure of S1PR2-heterotrimeric G13 signaling complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Li, X., Chen, H. 3.19 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6okp K L 0 E protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/14/19 B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.28 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 5jxe G F 0 A protein programmed cell death protein 1 IMMUNE SYSTEM 05/13/16 Human PD-1 ectodomain complexed with Pembrolizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Na, Z., Bharath, S.R., Song, H. 2.9 X-RAY DIFFRACTION 0.286 0.261 False True IGHV1 IGKV3 Kappa None None None None None 3eo1 B A 0 C protein transforming growth factor beta-3 IMMUNE SYSTEM/CYTOKINE 09/26/08 Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Gruetter, C., Gruetter, M.G. 3.1 X-RAY DIFFRACTION 0.279 0.255 False True IGHV1 IGKV8 Kappa 2.50e-10 -13.09 Other 19073914 6dw2 B A 0 B unknown HD4 unknown IMMUNE SYSTEM 06/26/18 Structure of the 6078 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fong, R., Lupardus, P.J. 1.7 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 IGKV1 Kappa None None None None None 3cdf NA B 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 6xbl S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/06/20 Structure of human SMO-Gi complex with SAG HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Qi, X., Li, X. 3.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7rk2 D d 0 A protein NA capsid protein vp25 VIRAL PROTEIN 07/21/21 Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 2D9, an astrovirus-neutralizing antibody, at 2.65-A resolution HUMAN ASTROVIRUS-8; MUS MUSCULUS mus musculus human astrovirus-8 Meyer, L., Cuellar, C., DuBois, R.M. 2.65 X-RAY DIFFRACTION 0.247 0.218 True True unknown unknown unknown None None None None None 4isv B A 0 IMMUNE SYSTEM 01/17/13 Crystal structure of the Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR POLY-GLUTAMINE MUS MUSCULUS mus musculus mus musculus Klein, F.A.C., Zeder-Lutz, G., Cousido-Siah, A, Mitschler, A., Katz, A., Eberling, P., Mandel, J.L., Podjarny, A., Trottier, Y. 1.497 X-RAY DIFFRACTION 0.218 0.198 False True IGHV9 IGLV3 Lambda None None None None None 7e88 D E 0 F protein NA spike protein s1 VIRAL PROTEIN,IMMUNE SYSTEM 03/01/21 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-515 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, C., Wei, Y., Xiao, J. 3.14 X-RAY DIFFRACTION 0.255 0.217 False True IGHV3 IGKV1 Kappa None None None None None 7p78 B NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 1up/1up-out/1down conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6qn8 H L 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV Fab B13 BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.12 X-RAY DIFFRACTION 0.267 0.235 False True IGHV1 IGLV1 Lambda None None None None None 6cdi H L 0 D protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6weq K L 0 D protein NA non-structural protein 1 VIRAL PROTEIN 04/02/20 DENV1 NS1 in complex with neutralizing 2B7 Fab fragment DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Akey, D.L., Smith, J.L. 3.2 X-RAY DIFFRACTION 0.261 0.207 False False IGHV1 IGKV3 Kappa None None None None None 3cm9 B M 0 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 1u8o B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKHAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 3.02 X-RAY DIFFRACTION 0.215 0.211 False False IGHV2 IGKV1 Kappa None None None None None 7d3k H L 0 2 protein NA o/tibet/99 vp2 VIRUS 09/19/20 FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY B77 BOS TAURUS; FOOT-AND-MOUTH DISEASE VIRUS bos taurus bos taurus foot-and-mouth disease virus He, Y., Lou, Z. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7kde M N 0 E protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 10/08/20 BG505 SOSIP.664 in complex with the V3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 5iml B NA 0 A protein v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 03/06/16 Nanobody targeting human Vsig4 in Spacegroup P212121 HOMO SAPIENS; CAMELIDAE camelidae homo sapiens Wen, Y. 1.8 X-RAY DIFFRACTION 0.226 0.181 False True IGHV1 None None None None None 4hh9 D C 0 IMMUNE SYSTEM 10/09/12 Anti-Human Cytomegalovirus (HCMV) Fab KE5 HOMO SAPIENS homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Pfoh, R., Schrader, J.W., Pai, E.F. 1.7 X-RAY DIFFRACTION 0.224 0.217 False False IGHV3 IGKV3 Kappa None None None None None 6bb4 H L 0 P peptide microtubule-associated protein tau IMMUNE SYSTEM 10/16/17 Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 2.099 X-RAY DIFFRACTION 0.270 0.218 False False IGHV1 IGKV11 Kappa 1.5400000000000002e-08 -10.658128680238939 Unknown TBD 7jvc F G 0 E protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2A4 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 2fjh H L 0 V protein vascular endothelial growth factor a HORMONE/GROWTH FACTOR/IMMUNE SYSTEM 01/02/06 Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.1 X-RAY DIFFRACTION 0.239 0.198 False True IGHV3 IGKV1 Kappa 3.80e-09 -11.94 SPR 37 16373345 6woq C D 0 F protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/25/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody HC1AM and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 3.667 X-RAY DIFFRACTION 0.277 0.227 False True IGHV1 IGKV2 Kappa None None None None None 6umg H L 0 C | R protein | protein NA | NA calcitonin gene-related peptide type 1 receptor | receptor activity-modifying protein 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 10/09/19 Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Mohr, C. 2.7 X-RAY DIFFRACTION 0.282 0.245 False True IGHV3 IGLV1 Lambda None None None None None 6s3t D C 0 S protein 46 kda surface antigen PROTEIN BINDING 06/26/19 P46, an immunodominant surface protein from Mycoplasma hyopneumoniae MYCOPLASMA HYOPNEUMONIAE J; MUS MUSCULUS mus musculus mus musculus mycoplasma hyopneumoniae j Guasch, A., Fita, I. 3.5 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 6vmj M L 0 W protein NA complement factor d HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 2.95 X-RAY DIFFRACTION 0.265 0.218 False True IGHV1 IGKV1 Kappa None None None None None 7dnk H L 0 D | A | C | E protein | protein | protein | protein NA | NA | NA | NA major capsid protein l1 | major capsid protein l1 | major capsid protein l1 | major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 12/09/20 2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of 5G9 HUMAN PAPILLOMAVIRUS TYPE 58; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 58 | human papillomavirus type 58 | human papillomavirus type 58 | human papillomavirus type 58 He, M.Z., Chi, X., Zha, Z.H., Zheng, Q.B., Gu, Y., Li, S.W., Xia, N.S. 6.41 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV16 Kappa None None None None None 4nhh M K 0 B protein 2g12 igg dimer heavy chain IMMUNE SYSTEM 11/05/13 Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 6.5 X-RAY DIFFRACTION 0.366 0.381 False True unknown IGKV1 Kappa None None None None None 7pgb i k 0 h protein NA unknown MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False False IGHV3 IGKV1 Kappa None None None None None 2w9e H L 0 A protein major prion protein IMMUNE SYSTEM 01/23/09 Structure of ICSM 18 (anti-Prp therapeutic antibody) Fab fragment complexed with human Prp fragment 119-231 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Antonyuk, S.V., Trevitt, C.R., Strange, R.W., Jackson, G.S., Sangar, D., Batchelor, M., Jones, S., Georgiou, T., Cooper, S., Fraser, C., Khalili-Shirazi, A., Clarke, A.R., Hasnain, S.S., Collinge, J. 2.9 X-RAY DIFFRACTION 0.269 0.207 False False IGHV1 IGKV4 Kappa 1.00e-10 -13.63 Other 19204296 7kr5 H L 0 B | A protein | protein NA | NA calcium release-activated calcium channel protein 1 | calcium release-activated calcium channel protein 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 11/18/20 Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster | drosophila melanogaster Long, S.B., Hou, X., Outhwaite, I.R. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV6 Kappa None None None None None 2h3n NA C 0 D protein ig lambda-5 IMMUNE SYSTEM 05/22/06 Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer HOMO SAPIENS homo sapiens homo sapiens Bankovich, A.J., Garcia, K.C. 2.3 X-RAY DIFFRACTION 0.281 0.228 False True unknown unknown unknown None None None None None 6p4y H L 0 NA NA NA NA IMMUNE SYSTEM 05/29/19 Crystal Structure of anti-IL-7Ralpha 4A10 Fab MUS MUSCULUS mus musculus mus musculus Walsh, S.T.R., Kashi, L., Kohnhorst, C.L. 1.799 X-RAY DIFFRACTION 0.231 0.188 False False IGHV1 IGKV19 Kappa None None None None None 6vrq A B 0 NA NA NA NA IMMUNE SYSTEM 02/08/20 Crystal structure of gl12A21 Fab in complex with anti-idiotypic iv12 Fab MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Aljedani, S.S., Weidle, C., Pancera, M. 2.57 X-RAY DIFFRACTION 0.241 0.189 False True IGHV1 IGKV1 Kappa None None None None None 1zmy A NA 0 L protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/11/05 cAbBCII-10 VHH framework with CDR loops of cAbLys3 grafted on it and in complex with hen egg white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Saerens, D., Pellis, M., Loris, R., Pardon, E., Dumoulin, M., Matagne, A., Wyns, L., Muyldermans, S., Conrath, K. 3.0 X-RAY DIFFRACTION 0.254 0.206 False True IGHV1 5.20e-08 -9.93 SPR 16095608 5tsj 1 NA 0 J | H protein | protein NA | NA v-type atpase subunit g | v-type atp synthase subunit e membrane protein, hydrolase 10/29/16 Thermus thermophilus V/A-ATPase bound to VH dAbs HOMO SAPIENS; THERMUS THERMOPHILUS (STRAIN HB8 / ATCC 27634 / DSM 579) homo sapiens thermus thermophilus (strain hb8 / atcc 27634 /dsm 579) | thermus thermophilus (strain hb8 / atcc 27634 /dsm 579) Davies, R.B., Smits, C., Wong, A.S.W., Stock, D., Sandin, S., Stewart, A.G. 8.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7rm0 E F 0 R peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2E10.E9 in complex with P. vivax CSP peptide ANGAGNQPGANGAGNQPG MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 2.71 X-RAY DIFFRACTION 0.246 0.209 False True IGHV9 IGKV8 Kappa None None None None None 2fr4 H L 0 N nucleic-acid 5'-d(*cp*tp*gp*cp*cp*tp*tp*cp*ap*g)-3' IMMUNE SYSTEM/DNA 01/18/06 Structure of Fab DNA-1 complexed with a stem-loop DNA ligand MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Tanner, J.J., Ou, Z. 1.95 X-RAY DIFFRACTION 0.256 0.207 False True IGHV1 IGKV12 Kappa 4e-06 -7.3641077518219635 Unknown TBD 7cvy D E 0 B protein NA e2 glycoprotein IMMUNE SYSTEM/VIRUS 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124 MUS MUSCULUS; CHIKUNGUNYA VIRUS mus musculus mus musculus chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 5.2 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 4y5x A B 0 C protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 3.15 X-RAY DIFFRACTION 0.241 0.201 False True IGHV3 IGLV1 Lambda None None None None None 7zmv E NA 0 D protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.002 X-RAY DIFFRACTION 0.275 0.242 False True IGHV1 NA NA None None None None None 3lrs E F 0 F carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/11/10 Structure of PG16, an antibody with broad and potent neutralization of HIV-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pancera, M., Kwong, P.D. 2.37 X-RAY DIFFRACTION 0.260 0.211 False True IGHV3 IGLV2 Lambda None None None None None 6uye H K 0 B protein sgp VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 EBOV GPdMuc Makona bound to rEBOV-548 Fab EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.96 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 5f6h O P 0 IMMUNE SYSTEM 12/06/15 Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.66 X-RAY DIFFRACTION 0.262 0.230 False True IGHV3 IGLV2 Lambda None None None None None 4ttd H L 0 A protein lysozyme c IMMUNE SYSTEM 06/20/14 Structure of a lysozyme antibody complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Wensley, B. 2.15 X-RAY DIFFRACTION 0.279 0.255 False True IGHV3 IGLV1 Lambda None None None None None 7mmn M G 0 K protein NA fusion glycoprotein f1,fibritin IMMUNE SYSTEM/VIRAL PROTEIN 04/29/21 Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; ENTEROBACTERIA PHAGE T4 homo sapiens homo sapiens human respiratory syncytial virus,enterobacteria phage t4 Harshbarger, W., Malito, E. 3.57 X-RAY DIFFRACTION 0.245 0.202 False True IGHV3 IGKV1 Kappa None None None None None 5dd6 A B 0 IMMUNE SYSTEM 08/24/15 Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I., Pemble IV, C.W., Haynes, B.F. 1.699 X-RAY DIFFRACTION 0.224 0.191 False True IGHV4 IGKV1 Kappa None None None None None 6z06 H L 0 A protein NA envelope polyprotein VIRAL PROTEIN 05/07/20 Crystal structure of Puumala virus Gc in complex with Fab 4G2 MYODES GLAREOLUS; PUUMALA ORTHOHANTAVIRUS myodes glareolus myodes glareolus puumala orthohantavirus Rissanen, I.R., Stass, R., Krumm, S.A., Seow, J., Hulswit, R.J.G., Paesen, G.C., Hepojoki, J., Vapalahti, O., Lundkvist, A., Reynard, O., Volchkov, V., Doores, K.J., Huiskonen, J.T., Bowden, T.A. 3.5 X-RAY DIFFRACTION 0.264 0.217 False True IGHV5 unknown unknown None None None None None 3pnw N M 0 O protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 6vbg C NA 0 A protein NA galactoside permease PROTEIN TRANSPORT 12/18/19 Lactose permease complex with thiodigalactoside and nanobody 9043 ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Kumar, H., Stroud, R.M., Kaback, H.R., Finer-Moore, J., Smirnova, I., Kasho, V., Pardon, E., Steyart, J. 2.8 X-RAY DIFFRACTION 0.275 0.239 False True IGHV1 NA NA None None None None None 7lu9 m n 0 I carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta Manne, K., Edwards, R.J., Acharya, P. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7s13 I M 0 C protein NA t-cell surface protein tactile IMMUNE SYSTEM 08/31/21 Crystal structure of Fab in complex with mouse CD96 dimer RATTUS; MUS MUSCULUS rattus rattus mus musculus Lee, P.S., Barman, I., Strop, P. 2.12 X-RAY DIFFRACTION 0.265 0.217 False True IGHV2 IGLV3 Lambda None None None None None 6bzw A B 0 J peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody AP33 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.2 X-RAY DIFFRACTION 0.231 0.192 False True IGHV3 IGKV3 Kappa None None None None None 7lrt F G 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/17/21 Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody A23-58.1 that targets the receptor-binding domain HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3oko B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 08/25/10 Crystal structure of S25-39 in complex with Kdo(2.8)Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Blackler, R.J., Evans, S.V. 2.45 X-RAY DIFFRACTION 0.267 0.210 False False IGHV7 IGKV8 Kappa None None None None None 6eyo H L 0 A protein immunoglobulin heavy constant epsilon IMMUNE SYSTEM 11/13/17 Structure of extended IgE-Fc in complex with two anti-IgE Fabs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chen, J.B., Ramadani, F., Pang, M.O.Y., Beavil, R.L., Holdom, M.D., Mitropoulou, A.N., Beavil, A.J., Gould, H.J., Chang, T.W., Sutton, B.J., McDonnell, J.M., Davies, A.M. 3.7 X-RAY DIFFRACTION 0.288 0.247 False True IGHV1 IGKV3 Kappa 2e-11 -14.596006591193015 SPR TBD 1mf2 H L 0 IMMUNOGLOBULIN 12/27/96 ANTI HIV1 PROTEASE FAB COMPLEX MUS MUSCULUS mus musculus mus musculus Lescar, J., Bentley, G.A. 2.6 X-RAY DIFFRACTION 0.307 0.206 False False IGHV5 IGKV3 Kappa None None None None None 7sg5 H L 0 A peptide NA pfcsp peptide 21 IMMUNE SYSTEM 10/05/21 Structure of PfCSP peptide 21 with antibody CIS43_Var2 Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Tripathi, P., Kwong, P.D. 1.4 X-RAY DIFFRACTION 0.218 0.185 False True IGHV1 IGKV4 Kappa None None None None None 5mv4 L M 0 N peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 7o30 B A 0 Q peptide NA pas#1 epitope peptide IMMUNE SYSTEM 04/01/21 Crystal structure of the anti-PAS Fab 1.1 in complex with its epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Schilz, J., Schiefner, A., Skerra, A. 2.65 X-RAY DIFFRACTION 0.269 0.220 False True IGHV2 IGKV3 Kappa None None None None None 1rjc A NA 0 B protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 11/19/03 Crystal structure of the camelid single domain antibody cAb-Lys2 in complex with hen egg white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus De Genst, E., Silence, K., Ghahroudi, M.A., Decanniere, K., Loris, R., Kinne, J., Wyns, L., Muyldermans, S. 1.4 X-RAY DIFFRACTION 0.235 0.220 False True IGHV1 NA NA None None None None None 3ifp H L 0 P peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 2.95 X-RAY DIFFRACTION 0.269 0.235 False True IGHV8 IGKV1 Kappa 2.45e-08 -10.38 SPR 25 19923222 6w4m H L 0 G | N protein | peptide NA | NA clade a/e 93th057 hiv-1 gp120 core | m48u1 cd4 mimetic peptide VIRAL PROTEIN/IMMUNE SYSTEM 03/11/20 CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | synthetic construct Tolbert, W.D., Gohain, N., Pazgier, M. 3.2 X-RAY DIFFRACTION 0.301 0.241 False True IGHV1 IGKV3 Kappa None None None None None 2f5b H L 0 P peptide protein (gp41 epitope) IMMUNOGLOBULIN 04/09/99 CRYSTAL STRUCTURE OF FAB' FROM THE HIV-1 NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH ITS GP41 EPITOPE HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bryson, S., Julien, J.P., Hynes, R.C., Pai, E.F. 2.0 X-RAY DIFFRACTION 0.258 0.232 False False IGHV2 IGKV1 Kappa None None None None None 7mlv F NA 0 D protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2hfg H L 0 R peptide tumor necrosis factor receptor superfamily member 13c IMMUNE SYSTEM 06/23/06 Crystal structure of hBR3 bound to CB3s-Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G. 2.61 X-RAY DIFFRACTION 0.252 0.195 False True IGHV3 IGKV1 Kappa 6.00e-10 -12.57 SPR 25 16840730 5u3o H L 0 A peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.2_K3 Fab in Complex with HIV-1 gp41 MPER Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 1.761 X-RAY DIFFRACTION 0.192 0.161 False True IGHV3 IGKV1 Kappa None None None None None 7swd H h 0 D | E protein | protein NA | NA virion spike glycoprotein | small/secreted glycoprotein VIRAL PROTEIN/Immune System 11/19/21 Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound ZAIRE EBOLAVIRUS (STRAIN GABON-94); ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens zaire ebolavirus | zaire ebolavirus (strain gabon-94) Milligan, J.C., Yu, X., Saphire, E.O. 3.59 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1mci NA B 0 P peptide peptide n-acetyl-d-phe-l-his-d-pro-oh IMMUNE SYSTEM 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown 0.177 False True IGLV2 Lambda None None None None None 4x7e C NA 0 A protein capsid protein VIRAL PROTEIN 12/09/14 Crystal structure of norovirus GII.10 P domain in complex with Nano-85 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Hansman, G.H., Koromyslova, A.D. 2.11 X-RAY DIFFRACTION 0.218 0.189 False True IGHV1 7.000000000000001e-09 -11.125276798630649 ITC TBD 5jmr B NA 0 IMMUNE SYSTEM 04/29/16 X-ray structure of an camelid VHH fragment CAMELUS DROMEDARIUS camelus dromedarius Dahms, S.O., Than, M.E. 2.27 X-RAY DIFFRACTION 0.216 0.190 False True IGHV3 None None None None None 7zmp C NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-055 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.626 X-RAY DIFFRACTION 0.359 0.332 False True IGHV1 NA NA None None None None None 6q0i H L 0 A protein hemagglutinin IMMUNE SYSTEM 08/01/19 Inferred intermediate I-7 (I-7-6) of the human antibody lineage 652 in complex with influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) McCarthy, K.R., Harrison, S.C. 2.702 X-RAY DIFFRACTION 0.255 0.213 False True IGHV4 IGLV3 Lambda None None None None None 3qa3 D C 0 G protein integrin alpha-m IMMUNE SYSTEM/ cell adhesion 01/10/11 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 3.0 X-RAY DIFFRACTION 0.224 0.194 False False IGHV14 IGKV8 Kappa None None None None None 5n0a I M 0 B protein envelope glycoprotein e Immune System/Viral protein 02/02/17 Crystal structure of A259C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Vaney, M.C., Rouvinski, A., Guardado-Calvo, P., Sharma, A., Rey, F.A. 3.9 X-RAY DIFFRACTION 0.300 0.285 False True IGHV3 IGLV2 Lambda None None None None None 6tnp B A 0 H unknown NO8 unknown IMMUNE SYSTEM 12/09/19 Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide MUS MUSCULUS mus musculus mus musculus mus musculus Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. 3.0 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV8 Kappa None None None None None 3k1k D NA 0 B protein green fluorescent protein LUMINESCENT PROTEIN/IMMUNE SYSTEM 09/28/09 Green fluorescent protein bound to minimizer nanobody AEQUOREA VICTORIA; CAMELUS DROMEDARIUS lama pacos aequorea victoria Kirchhofer, A., Helma, J., Schmidthals, K., Frauer, C., Cui, S., Karcher, A., Pellis, M., Muyldermans, S., Delucci, C.C., Cardoso, M.C., Leonhardt, H., Hopfner, K.-P., Rothbauer, U. 2.15 X-RAY DIFFRACTION 0.255 0.212 False True IGHV1 None None None None None 1i7z B A 0 A Hapten COC COCAINE IMMUNE SYSTEM 03/12/01 ANTIBODY GNC92H2 BOUND TO LIGAND MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Larsen, N.A., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.265 0.220 False True IGHV9 IGKV3 Kappa 4e-07 -8.728351841232218 Unknown TBD 7zf9 A B 0 C protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron BA.2 RBD in complex with COVOX-150 Fab (P21) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.265 0.222 False True IGHV3 IGKV1 Kappa None None None None None 5veb H L 0 Y protein cadherin-6 IMMUNE SYSTEM 04/04/17 Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhu, X., Bialucha, C.U., London, A., Clark, K., Hu, T. 2.34 X-RAY DIFFRACTION 0.252 0.212 False False IGHV3 IGKV1 Kappa None None None None None 7p60 H NA 0 D protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4 at 1:0.5 ratio MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7e3k F G 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/09/21 Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Li, T., Liu, F., Gao, Y., Ji, X., Yang, H. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1mcw NA M 0 IMMUNOGLOBULIN 05/09/89 THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY HOMO SAPIENS homo sapiens Ely, K.R., Herron, J.N., Edmundson, A.B. 3.5 X-RAY DIFFRACTION unknown unknown False False IGLV2 Lambda None None None None None 5f93 D NA 0 B protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.99 X-RAY DIFFRACTION 0.234 0.181 False True IGHV1 None None None None None 6cse A B 0 C protein sodium/alanine symporter agcs MEMBRANE PROTEIN 03/20/18 Crystal structure of sodium/alanine symporter AgcS with L-alanine bound METHANOCOCCUS MARIPALUDIS (STRAIN S2 / LL); MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis (strain s2 / ll) Ma, J., Reyes, F.E., Gonen, T. 3.24 X-RAY DIFFRACTION 0.251 0.230 False False IGHV6 IGKV12 Kappa None None None None None 6sc7 B NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-Ligand3 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.56 X-RAY DIFFRACTION 0.267 0.224 False True IGHV3 None None None None None 7nis F NA 0 NA NA NA NA VIRAL PROTEIN 02/13/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core CAMELIDAE MIXED LIBRARY; INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); STAPHYLOCOCCUS AUREUS; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 5.96 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3idy B C 0 A protein hiv-1 hxbc2 gp120 core IMMUNE SYSTEM 07/22/09 Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C2221 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chen, L., Kwon, Y.D., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z.Y., Zhang, M.Y., Arthos, J., Burton, D.R., Dimitrov, D.S., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D. 3.2 X-RAY DIFFRACTION 0.237 0.196 False True IGHV3 IGKV1 Kappa 4.04e-09 -11.450944611411623 SPR TBD 6iw2 N O 0 M protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state YELLOW FEVER VIRUS (STRAIN 17D VACCINE); HOMO SAPIENS homo sapiens homo sapiens yellow fever virus (strain 17d vaccine) Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 2.9 X-RAY DIFFRACTION 0.272 0.238 False True IGHV4 IGKV1 Kappa None None None None None 6xv8 B NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/21/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_G10 LAMA GLAMA; HELICOBACTER PYLORI (STRAIN G27) lama glama, helicobacter pylori (strain g27) Steyaert, J., Uchanski, T., Fischer, B. 3.15 X-RAY DIFFRACTION 0.297 0.255 False True IGHV1 NA NA None None None None None 6bzv C D 0 J peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.654 X-RAY DIFFRACTION 0.241 0.199 False True IGHV3 IGKV3 Kappa None None None None None 3hi5 H L 0 IMMUNE SYSTEM 05/18/09 Crystal structure of Fab fragment of AL-57 HOMO SAPIENS homo sapiens homo sapiens Zhang, H., Wang, J. 2.5 X-RAY DIFFRACTION 0.277 0.234 False True IGHV3 IGKV1 Kappa None None None None None 6bpe H I 0 G protein reticulocyte binding protein 2, putative CELL INVASION 11/22/17 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 6H1 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus mus musculus plasmodium vivax (strain salvador i) Gruszczyk, J., Chan, L.J., Tham, W.H. 3.34 X-RAY DIFFRACTION 0.367 0.318 False False IGHV5 IGKV6 Kappa None None None None None 7f7e C L 0 E protein NA spike protein s1 VIRAL PROTEIN 06/29/21 SARS-CoV-2 S protein RBD in complex with A5-10 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dou, Y., Wang, X., Wang, K., Liu, P., Lu, B. 2.49 X-RAY DIFFRACTION 0.256 0.214 False True IGHV3 IGKV1 Kappa None None None None None 5dtf A B 0 B Hapten 5CT Hypusine IMMUNE SYSTEM 09/18/15 context-independent anti-hypusine antibody FabHpu98.61 in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Zhai, Q., Carter, P.J. 1.9 X-RAY DIFFRACTION 0.254 0.212 False True IGHV1 IGKV1 Kappa None None None None None 2bx5 NA K 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 5xp1 NA G 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 3piq E F 0 IMMUNE SYSTEM 11/07/10 Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1 HOMO SAPIENS homo sapiens homo sapiens Changela, A., Gorny, M.K., Zolla-Pazner, S., Kwong, P.D. 3.325 X-RAY DIFFRACTION 0.299 0.236 False True IGHV3 IGLV3 Lambda None None None None None 6feq F E 0 A protein atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 01/03/18 Structure of inhibitor-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Altmann, K.H., Locher, K.P. 3.6 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 3mod H L 0 P peptide gp41 mper-derived peptide IMMUNE SYSTEM 04/22/10 Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced IgG) with 11 aa gp41 MPER-derived peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 2.2 X-RAY DIFFRACTION 0.214 0.184 False True IGHV2 IGKV1 Kappa None None None None None 3thm H L 0 F protein NA tumor necrosis factor receptor superfamily member 6 IMMUNE SYSTEM 08/19/11 Crystal structure of Fas receptor extracellular domain in complex with Fab EP6b_B01 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zuger, S., Stirnimann, C., Briand, C., Grutter, M.G. 2.1 X-RAY DIFFRACTION 0.221 0.183 False True IGHV4 IGLV1 Lambda None None None None None 7mfa M N 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA+P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.286 0.238 False True IGHV3 IGLV3 Lambda None None None None None 1ngy B A 0 IMMUNE SYSTEM 12/18/02 Chimeric Mature Fab 7g12-Apo MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Yin, J., Andryski, S.A., Beuscher, A.B., Stevens, R.C., Schultz, P.G. 2.2 X-RAY DIFFRACTION 0.273 0.235 False True IGHV1 IGKV6 Kappa None None None None None 7llk G H 0 E protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/21 Cryo-EM structure of Q23.17_DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody 179NC75 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 4.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 1xfp A NA 0 L protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 09/15/04 Crystal structure of the CDR2 germline reversion mutant of cAb-Lys3 in complex with hen egg white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus De Genst, E., Handelberg, F., Van Meirhaeghe, A., Vynck, S., Loris, R., Wyns, L., Muyldermans, S. 1.5 X-RAY DIFFRACTION 0.216 0.201 False True IGHV1 NA NA None None None None None 6u02 D C 0 B protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/19 CryoEM-derived model of NA-63 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.05 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6ca7 H L 0 IMMUNE SYSTEM 01/29/18 Crystal structure of PCT64_13C, a strain specific anti-HIV antibody HOMO SAPIENS homo sapiens homo sapiens Murrell, S., Wilson, I.A. 1.643 X-RAY DIFFRACTION 0.190 0.169 False True IGHV3 IGKV3 Kappa None None None None None 5a3i G H 0 E protein NA hemagglutinin VIRAL PROTEIN 06/01/15 Crystal Structure of a Complex formed between FLD194 Fab and Transmissible Mutant H5 Haemagglutinin INFLUENZA A VIRUS (A/VIETNAM/1203/2004(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/vietnam/1203/2004(h5n1)) Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S.R., Lin, Y.P., Walker, P.A., Collins, P.J., Monne, I., Suguitan Jr, A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J.J. 2.89 X-RAY DIFFRACTION 0.277 0.244 False False IGHV5 IGKV2 Kappa None None None None None 5obf H L 0 IMMUNE SYSTEM 06/26/17 fAb. AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery. MUS MUSCULUS mus musculus mus musculus Vicentini, G., Convery, M.A. 1.92 X-RAY DIFFRACTION 0.210 0.174 False True IGHV14 IGKV2 Kappa None None None None None 4yfl H L 0 G protein envelope glycoprotein gp160,envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 02/25/15 Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Zhou, T., Moquin, S., Kwong, P.D. 3.387 X-RAY DIFFRACTION 0.326 0.268 False True unknown IGLV1 Lambda None None None None None 6iyn A NA 5 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 5d1z D C 0 I protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT1 bound by clone D4-10 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN MSSA476) homo sapiens homo sapiens staphylococcus aureus (strain mssa476) Deng, X. 3.17 X-RAY DIFFRACTION 0.287 0.233 False True IGHV4 IGKV1 Kappa None None None None None 7tb8 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/21 Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 2.83 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1dqq B A 0 IMMUNE SYSTEM 01/04/00 CRYSTAL STRUCTURE OF ANTI-LYSOZYME ANTIBODY HYHEL-63 MUS MUSCULUS mus musculus mus musculus Li, H., Mariuzza, R.A. 1.8 X-RAY DIFFRACTION 0.255 0.210 False True IGHV3 IGKV5 Kappa None None None None None 7mdw A NA 0 R protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/06/21 CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb105 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D.J. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4nbz D NA 0 C protein tcda IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A1 Bound to A26.8 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 1.75 X-RAY DIFFRACTION 0.247 0.206 False True IGHV1 None None None None None 2ajv H L 0 L Hapten COC COCAINE IMMUNE SYSTEM 08/02/05 Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with Cocaine MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 1.5 X-RAY DIFFRACTION 0.227 0.182 False False IGHV3 IGKV2 Kappa None None None None None 4fqr e f 0 E protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 1nmc H L 0 N protein neuraminidase COMPLEX (SINGLE-CHAIN ANTIBODY/ANTIGEN) 12/21/97 COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 15 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Malby, R.L., Mccoy, A.J., Kortt, A.A., Hudson, P.J., Colman, P.M. 2.5 X-RAY DIFFRACTION 0.260 0.220 False True IGHV1 IGKV10 Kappa None None None None None 5cus I M 0 B protein receptor tyrosine-protein kinase erbb-3 TRANSFERASE 07/25/15 Crystal Structure of sErbB3-Fab3379 Complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, S., Schlessinger, J. 3.2 X-RAY DIFFRACTION 0.278 0.252 False True IGHV3 IGLV1 Lambda None None None None None 7sp7 B NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus hyaluronan synthase inhibited by UDP PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2; LAMA GLAMA lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4zyk H L 0 IMMUNE SYSTEM 05/21/15 Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14 HOMO SAPIENS homo sapiens homo sapiens Gilman, M.S.A., McLellan, J.S. 2.0 X-RAY DIFFRACTION 0.226 0.186 False True IGHV3 IGKV1 Kappa None None None None None 6w1c L P 0 H protein NA e2 glycoprotein VIRUS/IMMUNE SYSTEM 03/04/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain MAYARO VIRUS (STRAIN BRAZIL); HOMO SAPIENS homo sapiens homo sapiens mayaro virus (strain brazil) Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 7dk6 a b 0 A protein NA the heavy chain of 2h2 fab VIRAL PROTEIN 11/23/20 S-2H2-F2 structure, two RBDs are up and one RBD is down, each up RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 4.3 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 5mub F G 0 H peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 2bx5 NA F 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 5nml I NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 1u8m B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKYAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.4 X-RAY DIFFRACTION 0.225 0.218 False False IGHV2 IGKV1 Kappa None None None None None 4tuk H L 0 I peptide peptide2 IMMUNE SYSTEM 06/24/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus phage #d Golik, P., Grudnik, P., Dubin, G., Horwacik, I., Zdzalik, M., Rokita, H. 1.6 X-RAY DIFFRACTION 0.206 0.162 False True IGHV1 IGKV1 Kappa None None None None None 2vxs H L 0 B protein interleukin-17a CYTOKINE 07/09/08 Structure of IL-17A in complex with a potent, fully human neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gerhardt, S., Hargreaves, D., Pauptit, R.A., Davies, R.A., Russell, C., Welsh, F., Tuske, S.J., Coales, S.J., Hamuro, Y., Needham, M.R.C., Langham, C., Barker, W., Bell, P., Aziz, A., Smith, M.J., Dawson, S., Abbott, W.M. 2.63 X-RAY DIFFRACTION 0.264 0.213 False True IGHV3 IGLV6 Lambda 2.10e-09 -11.83 SPR 19835883 2itd A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 10/19/06 Potassium Channel KcsA-Fab complex in Barium Chloride STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Lockless, S.W., Zhou, M., MacKinnon, R. 2.7 X-RAY DIFFRACTION 0.261 0.241 False False IGHV1 IGKV5 Kappa None None None None None 7p5w J NA 0 D protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3v6f C D 0 IMMUNE SYSTEM 12/19/11 Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound MUS MUSCULUS mus musculus mus musculus Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. 2.52 X-RAY DIFFRACTION 0.220 0.179 False False IGHV5 IGKV8 Kappa None None None None None 2fjf P O 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 4g7v H L 0 S protein voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.5 A) CIONA INTESTINALIS; HOMO SAPIENS homo sapiens homo sapiens ciona intestinalis Li, Q. 2.5 X-RAY DIFFRACTION 0.240 0.201 False True IGHV3 IGKV1 Kappa None None None None None 6iyn A NA 1 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 6qfa L NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 01/09/19 CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 HOMO SAPIENS; HELICOBACTER PYLORI (STRAIN G27); LAMA GLAMA helicobacter pylori (strain g27), lama glama homo sapiens Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkoening, A., Zoegg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6u54 A NA 0 B protein nucleoprotein IMMUNE SYSTEM 08/26/19 Anti-Zaire ebolavirus Nucleoprotein Single Domain Antibody Zaire C (ZC) Complexed with Zaire ebolavirus Nucleoprotein C-terminal Domain 634-739 LAMA GLAMA; ZAIRE EBOLAVIRUS (STRAIN KIKWIT-95) lama glama zaire ebolavirus (strain kikwit-95) Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 1.6 X-RAY DIFFRACTION 0.215 0.173 False True IGHV1 None None None None None 5occ H L 0 A protein low affinity immunoglobulin gamma fc region receptor ii-b IMMUNE SYSTEM 06/30/17 Crystal structure of CD32b (Fc Gamma Receptor IIb) in complex with Human IgG1 Fab fragment (6G08) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tews, I., Orr, C. 2.5 X-RAY DIFFRACTION 0.261 0.192 False True IGHV3 IGLV1 Lambda None None None None None 7ryv I J 0 NA NA NA NA IMMUNE SYSTEM 08/26/21 Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques MACACA MULATTA macaca mulatta macaca mulatta Yang, Z., Bjorkman, P.J. 2.5 X-RAY DIFFRACTION 0.254 0.216 False True IGHV1 IGLV1 Lambda None None None None None 7mx8 H L 0 NA NA NA NA IMMUNE SYSTEM 05/18/21 Crystal Structure of HPV L1-directed E7M03 Fab HOMO SAPIENS homo sapiens homo sapiens Singh, S., Pancera, M. 2.02 X-RAY DIFFRACTION 0.246 0.208 False True IGHV4 IGKV3 Kappa None None None None None 7l1u H h 0 A | B protein | protein NA | NA engineered guanine nucleotide-binding protein subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/15/20 Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB) HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Hong, C., Byrne, N.J., Zamlynny, B., Tummala, S., Xiao, L., Shipman, J.M., Partridge, A.T., Minnick, C., Breslin, M.J., Rudd, M.T., Stachel, S.J., Rada, V.L., Kern, J.C., Armacost, K.A., Hollingsworth, S.A., O'Brien, J.A., Hall, D.L., McDonald, T.P., Strickland, C., Brooun, A., Soisson, S.M., Hollenstein, K. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5gs1 D d 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 5fcu H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 12/15/15 CRYSTAL STRUCTURE OF THE INNER DOMAIN OF CLADE A/E HIV-1 GP120 IN COMPLEX WITH THE ADCC-POTENT RHESUS MACAQUE ANTIBODY JR4 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta human immunodeficiency virus 1 Gohain, N., Tolbert, W.D., Pazgier, M. 1.85 X-RAY DIFFRACTION 0.223 0.184 False True IGHV4 IGLV1 Lambda 6.000000000000001e-09 -11.216608560689204 SPR TBD 7x7d C NA 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 SARS-CoV-2 Delta RBD and Nb22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, Y., Ye, S. 2.92 X-RAY DIFFRACTION 0.256 0.205 False True IGHV1 NA NA None None None None None 6cez H L 0 P peptide hiv-1 gp120 v2 peptide con b IMMUNE SYSTEM 02/13/18 Crystal Structure of Rabbit Anti-HIV-1 gp120 V2 Fab 16C2 in complex with V2 peptide ConB ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Kong, X., Pan, R. 2.399 X-RAY DIFFRACTION 0.296 0.237 False True IGHV1 IGKV1 Kappa None None None None None 7cwn E D 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 6gkd H NA 0 F protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 6z10 B NA 0 A protein NA succinate receptor 1 MEMBRANE PROTEIN 05/11/20 Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist RATTUS NORVEGICUS; VICUGNA PACOS vicugna pacos rattus norvegicus Haffke, M., Villard, F. 2.269 X-RAY DIFFRACTION 0.223 0.204 False True IGHV1 NA NA None None None None None 7kdm F NA 0 E | D protein | protein NA | NA ricin chain b | ricin chain a TOXIN 10/08/20 Ricin bound to VHH antibody V5G6 LAMA GLAMA; RICINUS COMMUNIS lama glama ricinus communis | ricinus communis Rudolph, M.J. 2.301 X-RAY DIFFRACTION 0.238 0.187 False True IGHV1 NA NA None None None None None 7mw5 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6w4s H L 0 F protein NA solute carrier family 40 member 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 03/11/20 Structure of apo human ferroportin in lipid nanodisc HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Billesboelle, C.B., Azumaya, C.M., Gonen, S., Powers, A., Kretsch, R.C., Schneider, S., Arvedson, T., Dror, R.O., Cheng, Y., Manglik, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5k9q G I 0 D | C | E protein | protein | protein NA | NA | NA hemagglutinin ha2 | hemagglutinin ha1 | hemagglutinin ha1 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus | influenza a virus Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.503 X-RAY DIFFRACTION 0.218 0.182 False True IGHV1 IGKV1 Kappa None None None None None 1qlr D C 0 IMMUNOGLOBULIN 09/11/99 CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A HUMAN MONOCLONAL IgM COLD AGGLUTININ HOMO SAPIENS homo sapiens homo sapiens Carvalho, J.G., Cauerhff, A., Goldbaum, F., Leoni, J., Polikarpov, I. 2.83 X-RAY DIFFRACTION 0.265 0.216 False False IGHV4 IGKV3D Kappa None None None None None 7e9h D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/04/21 Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu4 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Lin, S., Han, S., Zhao, Q., Wu, B. 4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7pi3 B C 0 A protein NA monoclonal antibody cy.004 heavy chain IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 2kh2 B b 40 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7np1 I M 0 B protein NA spike protein s1 VIRAL PROTEIN 02/26/21 Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hall, G., Cowan, R., Carr, M. 2.8 X-RAY DIFFRACTION 0.281 0.232 False True IGHV3 IGKV1 Kappa None None None None None 1c5d H L 0 IMMUNE SYSTEM 11/17/99 THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Kontou, M., Leonidas, D.D., Vatzaki, E.H., Tsantili, P., Mamalaki, A., Oikonomakos, N.G., Acharya, K.R., Tzartos, S.J. 2.4 X-RAY DIFFRACTION 0.304 0.196 False False IGHV2 IGKV19 Kappa None None None None None 5f9a C NA 0 A protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain P436 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.44 X-RAY DIFFRACTION 0.257 0.205 False True IGHV1 None None None None None 7prz H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with beta-22 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.2 X-RAY DIFFRACTION 0.223 0.190 False True IGHV3 IGKV4 Kappa None None None None None 6xey J K 0 C protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/Immune System 06/14/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L., Ho, D.D. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 2kqm NA A 7 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6rqm B NA 0 A protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 05/16/19 A blocking anti-CTLA-4 Nanobody (KN044) complexed with CTLA-4 CAMELUS BACTRIANUS; HOMO SAPIENS camelus bactrianus homo sapiens Zhang, F., Zhou, A., Gao, H. 3.0 X-RAY DIFFRACTION 0.313 0.250 False True IGHV3 NA NA None None None None None 7te8 C NA 0 C Hapten P0T cannabidiol BIOSYNTHETIC PROTEIN 01/04/22 CA14-CBD-DB21 ternary complex ARTIFICIAL SEQUENCES artificial sequences artificial sequences Cao, S., Zheng, N. 1.998 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 NA NA None None None None None 6k68 F G 0 I protein protein a STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (8420-3MNZ) HUMAN IMMUNODEFICIENCY VIRUS 1; STAPHYLOCOCCUS AUREUS human immunodeficiency virus 1 human immunodeficiency virus 1 staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 3.2 X-RAY DIFFRACTION 0.318 0.289 False True IGHV9 IGKV8 Kappa None None None None None 2b2x H L 0 A protein integrin alpha-1 Immune system 09/19/05 VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Clark, L.A., Boriack-Sjodin, P.A., Eldredge, J., Fitch, C., Friedman, B., Hanf, K.J., Jarpe, M., Liparoto, S.F., Li, Y., Lugovskoy, A. 2.2 X-RAY DIFFRACTION 0.272 0.238 False True IGHV5 IGKV4 Kappa 1.72e-09 -11.95 Other 16597831 7shz E F 0 B protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with HAE HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.236 0.186 False True IGHV3 IGKV1 Kappa None None None None None 6rty B NA 0 A protein protein patched homolog 1 MEMBRANE PROTEIN 05/27/19 Crystal structure of the Patched ectodomain in complex with nanobody NB64 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Rudolf, A.F., Kowatsch, C., El Omari, K., Malinauskas, T., Kinnebrew, M., Ansell, T.B., Bishop, B., Pardon, E., Schwab, R.A., Qian, M., Duman, R., Covey, D.F., Steyaert, J., Wagner, A., Sansom, M.S.P., Rohatgi, R., Siebold, C. 2.1 X-RAY DIFFRACTION 0.255 0.216 False True IGHV1 None None None None None 2mkw NA A 15 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 3ze2 E F 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.35 X-RAY DIFFRACTION 0.2037 0.1753 False True IGHV14 IGKV14 Kappa None None None None None 3mlt I G 0 IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens Kong, X.-P. 2.49 X-RAY DIFFRACTION 0.280 0.202 False False IGHV5 IGLV3 Lambda None None None None None 6uul A B 0 E carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/30/19 Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5 HOMO SAPIENS homo sapiens homo sapiens Kumar, S., Wilson, I.A. 2.06 X-RAY DIFFRACTION 0.246 0.201 False True unknown IGKV3 Kappa None None None None None 7zf5 B C 0 A protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-12 and Beta-54 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 5.32 X-RAY DIFFRACTION 0.256 0.249 False True IGHV4 IGKV1 Kappa None None None None None 4qhk M N 0 IMMUNE SYSTEM 05/28/14 UCA (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.487 X-RAY DIFFRACTION 0.285 0.269 False True IGHV4 IGLV3 Lambda None None None None None 5kel C D 0 A protein ebola surface glycoprotein, gp1 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 ZAIRE EBOLAVIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV8 IGKV6 Kappa None None None None None 3ze0 H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.95 X-RAY DIFFRACTION 0.2427 0.1847 False True IGHV14 IGKV14 Kappa None None None None None 6ot1 Q R 0 P protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 6oan D d 0 C protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 053054 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 2.9 X-RAY DIFFRACTION 0.252 0.230 True True unknown unknown unknown None None None None None 4u1g E F 0 D protein reticulocyte binding protein 5 IMMUNE SYSTEM 07/15/14 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody QA1 PLASMODIUM FALCIPARUM; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus plasmodium falciparum Wright, K.E., Hjerrild, K.A., Bartlett, J., Douglas, A.D., Jin, J., Brown, R.E., Ashfield, R., Clemmensen, S.B., de Jongh, W.A., Draper, S.J., Higgins, M.K. 3.1 X-RAY DIFFRACTION 0.281 0.236 False True IGHV5 IGKV3 Kappa None None None None None 2mmx NA A 10 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 5y9f N M 0 B protein NA heavy chain of fab fragment of antibody 28f10 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 5o0w F NA 0 B protein fructose-bisphosphate aldolase LYASE 05/17/17 Crystal structure of the complex between Nb474 and Trypanosoma congolense fructose-1,6-bisphosphate aldolase TRYPANOSOMA CONGOLENSE (STRAIN IL3000); VICUGNA PACOS vicugna pacos trypanosoma congolense (strain il3000) Pinto, J., Magez, S., Sterckx, Y. 2.57 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 7.382999999999999e-11 -13.822203424535738 SPR TBD 7a25 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/16/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6ldv H L 0 P peptide NA gly-m3l-gly-gly-thr-tyr-pro IMMUNE SYSTEM 11/23/19 Structure antibody F9 in complex with methylated peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Tsumoto, K. 1.9 X-RAY DIFFRACTION 0.229 0.179 False True IGHV1 IGKV1 Kappa None None None None None 6zxn D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/30/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4wht G H 0 g peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 7qnw H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 12/23/21 The receptor binding domain of SARS-CoV-2 Omicron variant spike glycoprotein in complex with Beta-55 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.4 X-RAY DIFFRACTION 0.247 0.206 False True IGHV3 IGKV1 Kappa None None None None None 2uud J K 0 T peptide nq10-1.12 anti-phox antibody IMMUNE SYSTEM 03/02/07 Crystal structure of the TEPC15-Vk45.1 anti-2-phenyl-5-oxazolone NQ10- 1.12 scFv in complex with the hapten MUS MUSCULUS mus musculus mus musculus mus musculus Scotti, C., Gherardi, E. 2.9 X-RAY DIFFRACTION 0.297 0.228 False True IGHV7 IGKV1 Kappa None None None None None 6udk H L 0 K protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 3u9u C D 0 Transferase 10/19/11 Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Hollmen, M., Liu, P., Wildiers, H., Reinvall, I., Vandorpe, T., Smeets, A., Deraedt, K., Vahlberg, T., Joensuu, H., Leahy, D.J., Schoffski, P., Elenius, K. 3.42 X-RAY DIFFRACTION 0.272 0.234 False True IGHV8 IGKV1 Kappa None None None None None 6ztf A B 0 NA NA NA NA IMMUNE SYSTEM 07/20/20 Crystal Structure of the anti-human P-Cadherin Fab CQY684 HOMO SAPIENS homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 1.55 X-RAY DIFFRACTION 0.207 0.188 False True IGHV6 IGKV1 Kappa None None None None None 5t3x H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/26/16 3.9 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gristick, H.B., Bjorkman, P.J. 3.9 X-RAY DIFFRACTION 0.331 0.296 False True IGHV4 unknown unknown None None None None None 3tnn A B 0 IMMUNE SYSTEM 09/01/11 Crystal structure of N5-i5 Fab, an ADCC mediating and non-neutralizing CD4i anti-HIV- 1 antibody. HOMO SAPIENS homo sapiens homo sapiens Wu, X., Pazgier, M. 1.95 X-RAY DIFFRACTION 0.245 0.198 False True IGHV3 IGLV2 Lambda None None None None None 5uk4 s NA 0 S protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 4jqi H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | vasopressin v2 receptor phosphopeptide SIGNALING PROTEIN 03/20/13 Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide RATTUS NORVEGICUS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus | Shukla, A.K., Manglik, A., Kruse, A.C., Xiao, K., Reis, R.I., Tseng, W.C., Staus, D.P., Hilger, D., Uysal, S., Huang, L.H., Paduch, M., Shukla, P.T., Koide, A., Koide, S., Weis, W.I., Kossiakoff, A.A., Kobilka, B.K., Lefkowitz, R.J. 2.6 X-RAY DIFFRACTION 0.247 0.201 False True IGHV3 IGKV1 Kappa None None None None None 2qtj A L 8 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 2rcj R S 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 4hjj H NA 0 A protein interleukin-18 IMMUNE SYSTEM 10/12/12 Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule HOMO SAPIENS homo sapiens homo sapiens Jakob, C.G., Edalji, R., Judge, R.A., DiGiammarino, E., Li, Y., Gu, J., Ghayur, T. 2.1 X-RAY DIFFRACTION 0.220 0.184 False True IGHV2 1.6e-10 -13.363971414233674 Unknown TBD 3upc D NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 6pzz I G 0 C protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 4k07 NA E 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 3etb G g 0 K protein anthrax protective antigen IMMUNE SYSTEM/TOXIN 10/07/08 Crystal structure of the engineered neutralizing antibody M18 complexed with anthrax protective antigen domain 4 MUS MUSCULUS; BACILLUS ANTHRACIS mus musculus bacillus anthracis Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D. 3.8 X-RAY DIFFRACTION 0.276 0.232 True True unknown unknown unknown 3.50e-11 -14.26 SPR 25 19361425 6jri H NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 2bx5 NA G 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 5n2k P O 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 3i02 B A 0 A carbohydrate KDA polysaccharide IMMUNE SYSTEM 06/24/09 Crystal structure of S54-10 antibody in complex with antigen Kdo(2.4)Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Muller-Loennies, S., Borisova, S.N., Brade, L., Kosma, P., Hirama, T., MacKenzie, C.R., Brade, H., Evans, S.V. 2.6 X-RAY DIFFRACTION 0.268 0.211 False False IGHV7 IGKV8 Kappa 3e-08 -10.26304286359873 Unknown TBD 5mv3 O P 0 Q peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 7qnd M NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6apc H L 0 IMMUNE SYSTEM 08/17/17 Crystal Structure of Infant Antibody ADI-19425 HOMO SAPIENS homo sapiens homo sapiens Gilman, M.S.A., McLellan, J.S. 1.7 X-RAY DIFFRACTION 0.204 0.174 False True IGHV3 IGLV1 Lambda None None None None None 7mno K M 0 B protein NA e3 sumo-protein ligase ranbp2 TRANSFERASE/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) I656V mutant in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 6.73 X-RAY DIFFRACTION 0.254 0.205 False True IGHV3 IGKV1 Kappa None None None None None 7l56 F G 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-43 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 5wux A B 0 F protein tumor necrosis factor alpha IMMUNE SYSTEM 12/21/16 TNFalpha-certolizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, J.U. 2.9 X-RAY DIFFRACTION 0.266 0.226 False True IGHV3 IGKV1 Kappa 2.7399999999999997e-11 -14.40948636554907 SPR TBD 7jtf A B 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 08/17/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM2-01 MACACA MULATTA; RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 3.35 X-RAY DIFFRACTION 0.296 0.242 False True IGHV1 IGKV1 Kappa None None None None None 7uar D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/13/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1717 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5hdb E F 0 C protein NA integrin alpha-iib MEMBRANE PROTEIN/IMMUNE SYSTEM 01/05/16 Integrin alphaIIbbeta3 in complex with Ro-435054 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lin, F.Y. 2.7012 X-RAY DIFFRACTION 0.238 0.212 False True IGHV14 IGKV14 Kappa None None None None None 1rei NA A 0 IMMUNOGLOBULIN(PART)SEQUESTERS ANTIGENS 03/17/76 THE MOLECULAR STRUCTURE OF A DIMER COMPOSED OF THE VARIABLE PORTIONS OF THE BENCE-JONES PROTEIN REI REFINED AT 2.0 ANGSTROMS RESOLUTION HOMO SAPIENS homo sapiens Epp, O., Lattman, E.E., Colman, P., Fehlhammer, H., Bode, W., Schiffer, M., Huber, R., Palm, W. 2.0 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 2j6e I M 0 B protein ig gamma-1 chain c region IMMUNE SYSTEM 09/28/06 Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation HOMO SAPIENS homo sapiens homo sapiens homo sapiens Duquerroy, S., Stura, E.A., Bressanelli, S., Browne, H., Beale, D., Hamon, M., Casali, P., Vaney, M.-C., Rey, F.A., Sutton, B.J., Taussig, M.J. 3.0 X-RAY DIFFRACTION 0.2877 0.2234 False True IGHV4 IGLV1 Lambda 6e-07 -8.488120381868695 Unknown TBD 1k4c A B 0 C protein potassium channel kcsa MEMBRANE PROTEIN 10/07/01 Potassium Channel KcsA-Fab complex in high concentration of K+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R. 2.0 X-RAY DIFFRACTION 0.233 0.218 False False IGHV1 IGKV5 Kappa None None None None None 6qf6 A a 0 APOPTOSIS 01/09/19 Structure of an E.coli expressed anti-Mcl1 scFv HOMO SAPIENS homo sapiens Luptak, J. 2.59 X-RAY DIFFRACTION 0.262 0.181 True True unknown unknown unknown None None None None None 6y9a H L 0 A | B protein | protein NA | NA b-lymphocyte antigen cd20 | b-lymphocyte antigen cd20 MEMBRANE PROTEIN 03/06/20 Structure of full-length CD20 in complex with Obinutuzumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Kumar, A., Reyes, N. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 5w9j E F 0 D protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6mb3 B M 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7q9j H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-26 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 6ey0 H NA 0 D protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 N-terminal part (residues 30-212) of PorM with the llama naobody nb01 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Roche, J., Cambillau, C., Roussel, A. 2.4 X-RAY DIFFRACTION 0.242 0.213 False True IGHV1 None None None None None 7dha C B 0 A protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 IMMUNE SYSTEM 11/13/20 crystal structure of CD38 in complex with daratumumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, H.T., Heo, Y.S. 2.55 X-RAY DIFFRACTION 0.261 0.207 False True IGHV3 IGKV3 Kappa None None None None None 4hlz I J 0 D | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 10/17/12 Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus | influenza a virus Dreyfus, C., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.228 False True IGHV7 IGKV12 Kappa 2e-09 -11.867518412372508 BLI TBD 7lez Q O 0 M | J protein | protein NA | NA arginase-1 | arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7we7 K N 0 G protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7c2s G H 0 B protein NA envelope protein VIRUS 05/09/20 Helical reconstruction of Dengue virus serotype 3 complexed with Fab C10 HOMO SAPIENS; DENGUE VIRUS 3 homo sapiens homo sapiens dengue virus 3 Morrone, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Zhang, S., Lok, S.M. 10.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 5m15 C NA 0 A protein maltose-binding periplasmic protein IMMUNE SYSTEM 10/07/16 Synthetic nanobody in complex with MBP ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct escherichia coli k-12 Zimmermann, I., Egloff, P., Seeger, M.A. 1.9 X-RAY DIFFRACTION 0.257 0.209 False True IGHV1 None None None None None 6a67 C D 0 B protein hemagglutinin IMMUNE SYSTEM 06/26/18 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody FLD21.140 HOMO SAPIENS; INFLUENZA A VIRUS (A/THAILAND/1(KAN-1)/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/thailand/1(kan-1)/2004(h5n1)) Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X. 2.33 X-RAY DIFFRACTION 0.235 0.197 False True IGHV4 IGLV1 Lambda 1.004e-09 -12.275831597239875 SPR TBD 4r7d M N 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 7e5r M U 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6obg C NA 0 A protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V8E6 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.996 X-RAY DIFFRACTION 0.218 0.189 False True IGHV1 None None None None None 7czw H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2G7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 6fy2 X Y 0 Z peptide cap225 scaffolded v1v2 IMMUNE SYSTEM 03/10/18 Crystal structure of a V2p-reactive RV144 vaccine-like antibody, CAP228-16H, in complex with a heterologous CAP225 V1V2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Moore, P.L., Morris, L. 2.301 X-RAY DIFFRACTION 0.217 0.190 False True IGHV5 IGLV3 Lambda None None None None None 7rgp N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/15/21 cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1lmk A a 0 IMMUNOGLOBULIN 08/29/94 THE STRUCTURE OF A BIVALENT DIABODY MUS MUSCULUS mus musculus Williams, R.L. 2.6 X-RAY DIFFRACTION unknown 0.200 True True unknown unknown unknown None None None None None 2mpa H L 0 P peptide conjugate of pora p1.16 peptide with fluorescein IMMUNE SYSTEM 06/09/99 BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Van Den Elsen, J.M.H., Herron, J.N., Kroon, J., Gros, P. 2.6 X-RAY DIFFRACTION 0.264 0.202 False False IGHV1 IGKV1 Kappa 9.1e-09 -10.969830253718456 Unknown TBD 6zfo B C 0 A protein NA spike glycoprotein IMMUNE SYSTEM 06/17/20 Association of two complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ke1 C D 0 NA NA NA NA IMMUNE SYSTEM 10/09/20 Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein HOMO SAPIENS homo sapiens homo sapiens Beernink, P.T., Sands, N. 1.5 X-RAY DIFFRACTION 0.183 0.162 False True IGHV3 IGKV3 Kappa None None None None None 7e5s R O 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 5bvj F E 0 IMMUNE SYSTEM 06/05/15 The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta HOMO SAPIENS homo sapiens homo sapiens Rondeau, J.M. 2.0 X-RAY DIFFRACTION 0.228 0.186 False True IGHV3 IGKV6 Kappa None None None None None 5ihl G NA 0 F protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 02/29/16 STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB HOMO SAPIENS homo sapiens homo sapiens Sheriff, S. 3.3 X-RAY DIFFRACTION 0.298 0.268 False True IGHV3 None None None None None 7klg I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 10/30/20 SARS-CoV-2 RBD in complex with Fab 15033 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 3.2 X-RAY DIFFRACTION 0.290 0.271 False True IGHV3 IGKV1 Kappa None None None None None 4wfe E D 0 A protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 2.5 X-RAY DIFFRACTION 0.234 0.199 False True IGHV1 IGKV4 Kappa None None None None None 3upc J NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 4uuj A B 0 C protein voltage-gated potassium channel kcsa IMMUNE SYSTEM/METAL TRANSPORT 07/29/14 POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Lenaeus, M.J., Burdette, D., Wagner, T., Focia, P.J., Gross, A. 2.4 X-RAY DIFFRACTION 0.24823 0.19148 False True IGHV1 IGKV5 Kappa None None None None None 5ec1 A B 0 C protein ph-gated potassium channel kcsa MEMBRANE PROTEIN 10/20/15 KcsA with V76ester mutation STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Matulef, K., Valiyaveetil, F.I. 2.75 X-RAY DIFFRACTION 0.268 0.244 False True IGHV1 IGKV5 Kappa None None None None None 7lyw H L 0 NA NA NA NA IMMUNE SYSTEM 03/08/21 Crystal structure of the HCMV pentamer-specific antibody 2-25 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., Mishra, A.K., McLellan, J.S. 2.51 X-RAY DIFFRACTION 0.219 0.187 False True IGHV1 IGLV3 Lambda None None None None None 6ieb H L 0 A protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R15 HOMO SAPIENS; RIFT VALLEY FEVER VIRUS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 2.409 X-RAY DIFFRACTION 0.246 0.195 False True IGHV4 IGLV3 Lambda None None None None None 7rah D C 0 E protein NA bifunctional adenylate cyclase toxin/hemolysin cyaa,bifunctional adenylate cyclase toxin/hemolysin cyaa IMMUNE SYSTEM/TOXIN 07/01/21 Adenylate cyclase toxin RTX domain fragment bound to M1H5 Fab and M2B10 Fab MUS MUSCULUS; BORDETELLA PERTUSSIS mus musculus mus musculus bordetella pertussis Goldsmith, J.A., McLellan, J.S. 2.6 X-RAY DIFFRACTION 0.218 0.195 False True IGHV1 IGKV4 Kappa None None None None None 7m3i H L 0 R protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 03/18/21 Structure of SARS-CoV-2 spike protein receptor binding domain in complex with a neutralizing antibody, CV2-75 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hurlburt, N.K., Pancera, M. 2.8 X-RAY DIFFRACTION 0.281 0.245 False True IGHV4 IGLV3 Lambda None None None None None 7wka c d 0 C protein NA heavy chain of s3h3 fab VIRAL PROTEIN 01/08/22 SARS-CoV-2 Omicron closed state spike protein in complex with S3H3 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 3.64 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 2mmx NA A 1 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6gkd B NA 0 A protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 3tnn C D 0 IMMUNE SYSTEM 09/01/11 Crystal structure of N5-i5 Fab, an ADCC mediating and non-neutralizing CD4i anti-HIV- 1 antibody. HOMO SAPIENS homo sapiens homo sapiens Wu, X., Pazgier, M. 1.95 X-RAY DIFFRACTION 0.245 0.198 False True IGHV3 IGLV2 Lambda None None None None None 6nfn R Q 0 Q Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 1bbj H L 0 IMMUNOGLOBULIN 04/30/92 CRYSTAL STRUCTURE OF A CHIMERIC FAB' FRAGMENT OF AN ANTIBODY BINDING TUMOUR CELLS HOMO SAPIENS homo sapiens Brady, R.L., Hubbard, R.E., Todd, R.J. 3.1 X-RAY DIFFRACTION unknown unknown False True IGHV1 IGKV12 Kappa None None None None None 4hcr M N 0 B protein mucosal addressin cell adhesion molecule 1 IMMUNE SYSTEM 10/01/12 Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Springer, T., Yu, Y., Zhu, J. 2.3 X-RAY DIFFRACTION 0.208 0.153 False True IGHV1 IGKV2D Kappa None None None None None 7v0v A NA 3 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7kbk C NA 0 A | B protein | protein NA | NA ricin | ricin TOXIN 10/02/20 Ricin bound to VHH antibody V6E11 VICUGNA PACOS; RICINUS COMMUNIS vicugna pacos ricinus communis | ricinus communis Rudolph, M.J. 2.091 X-RAY DIFFRACTION 0.203 0.172 False True IGHV1 NA NA None None None None None 6adb C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148N mutant CLC-ec1 in 20mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 2.692 X-RAY DIFFRACTION 0.278 0.237 False False IGHV4 IGKV4 Kappa None None None None None 6iw2 E F 0 D protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state YELLOW FEVER VIRUS (STRAIN 17D VACCINE); HOMO SAPIENS homo sapiens homo sapiens yellow fever virus (strain 17d vaccine) Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 2.9 X-RAY DIFFRACTION 0.272 0.238 False True IGHV4 IGKV1 Kappa None None None None None 1oaq H L 0 ANTIBODY 01/21/03 Free conformation Ab1 of the IgE SPE-7 RATTUS RATTUS rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 1.5 X-RAY DIFFRACTION 0.18167 0.15965 False True IGHV1 IGLV1 Lambda None None None None None 7aql C c 0 NA NA NA NA IMMUNE SYSTEM 10/22/20 Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7) MUS MUSCULUS mus musculus Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 1.8 X-RAY DIFFRACTION 0.223 0.186 True True unknown unknown unknown None None None None None 1m7d B A 0 A carbohydrate RAM polysaccharide IMMUNE SYSTEM 07/19/02 Crystal structure of a Monoclonal Fab Specific for Shigella flexneri Y Lipopolysaccharide complexed with a trisaccharide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Vyas, N.K., Vyas, M.N., Chervenak, M.C., Johnson, M.A., Pinto, B.M., Bundle, D.R., Quiocho, F.A. 2.3 X-RAY DIFFRACTION 0.279 0.216 False True IGHV6 IGKV1 Kappa 5.9e-07 -8.49807832517898 Unknown TBD 4ios E NA 0 A protein NA bpp VIRAL PROTEIN 01/08/13 Structure of phage TP901-1 RBP (ORF49) in complex with nanobody 11. LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 Desmyter, A., Farenc, C., Mahony, J., Spinelli, S., Bebeacua, C., Blangy, S., Veesler, D., van Sinderen, D., Cambillau, C. 2.4 X-RAY DIFFRACTION 0.227 0.201 False True IGHV1 NA NA None None None None None 3l5x H L 0 A protein interleukin-13 IMMUNE SYSTEM 12/22/09 Crystal structure of the complex between IL-13 and H2L6 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.247 0.197 False True IGHV2 IGKV3 Kappa 2.69e-10 -13.05 SPR 25 20226193 7akj H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/01/20 Structure of the SARS-CoV spike glycoprotein in complex with the 47D11 neutralizing antibody Fab fragment SARS CORONAVIRUS WH20; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus wh20 Fedry, J., Hurdiss, D.L., Wang, C., Li, W., Obal, G., Drulyte, I., Howes, S.C., van Kuppeveld, F.J.M., Foerster, F., Bosch, B.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7t0k F E 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 4 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.0 X-RAY DIFFRACTION 0.255 0.222 False True IGHV7 IGKV8 Kappa None None None None None 1dqq D C 0 IMMUNE SYSTEM 01/04/00 CRYSTAL STRUCTURE OF ANTI-LYSOZYME ANTIBODY HYHEL-63 MUS MUSCULUS mus musculus mus musculus Li, H., Mariuzza, R.A. 1.8 X-RAY DIFFRACTION 0.255 0.210 False True IGHV3 IGKV5 Kappa None None None None None 2ak1 H L 0 IMMUNE SYSTEM 08/02/05 Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with benzoic acid MUS MUSCULUS mus musculus mus musculus Zhu, X., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.238 0.217 False False IGHV3 IGKV2 Kappa None None None None None 7rby B NA 0 A protein NA spike protein s1 VIRAL PROTEIN 07/06/21 Crystal structure of Nanobody nb112 and SARS-CoV-2 RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Chen, Y., Tolbert, W., Pazgier, M. 2.82 X-RAY DIFFRACTION 0.287 0.201 False True IGHV1 NA NA None None None None None 5n09 H L 0 A protein envelope glycoprotein e Immune System/Viral Protein 02/02/17 Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Duquerroy, S., Rouvinski, A., Guardado-Calvo, P., Vaney, M.-C., Sharma, A., Rey, F. 3.9 X-RAY DIFFRACTION 0.347 0.304 False True IGHV3 IGLV2 Lambda None None None None None 2r1y B A 0 B carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 08/23/07 Crystal structure of S25-2 Fab in complex with Kdo analogues MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 1.6 X-RAY DIFFRACTION 0.255 0.229 False False IGHV7 IGKV8 Kappa 3.1e-05 -6.150883160475254 Unknown TBD 3dwt H NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 7kf1 G I 0 J protein NA isoform l-vegf206 of vascular endothelial growth factor a IMMUNE SYSTEM 10/13/20 Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M.S. 2.45 X-RAY DIFFRACTION 0.232 0.189 False True IGHV3 IGKV1 Kappa None None None None None 4fqr s t 0 S protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 6uyn H L 0 B | A protein | protein NA | NA hemagglutinin ha1 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 Crystal structure of influenza A virus hemagglutinin from A/Ohio/09/2015 bound to the stalk-binding CR6261 antibody Fab INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.85 X-RAY DIFFRACTION 0.248 0.209 False True IGHV1 IGLV1 Lambda None None None None None 2qtj D O 8 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5whz H NA 0 IMMUNE SYSTEM 07/18/17 PGDM1400-10E8v4 CODV Fab HOMO SAPIENS homo sapiens Lord, D.M., Wei, R.R. 3.549 X-RAY DIFFRACTION 0.287 0.239 False True IGHV3 None None None None None 2kh2 B b 66 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 4pfe B NA 0 FLUORESCENT PROTEIN 04/29/14 Crystal structure of vsfGFP-0 AEQUOREA VICTORIA aequorea victoria, vicugna pacos Jauch, R., Chen, S.L. 2.603 X-RAY DIFFRACTION 0.255 0.199 False True IGHV1 None None None None None 7pgb p q 0 o protein NA unknown MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False False IGHV3 IGKV1 Kappa None None None None None 6ch8 Q R 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4.1 X-RAY DIFFRACTION 0.274 0.229 False True unknown IGLV3 Lambda None None None None None 2gsg B A 0 IMMUNE SYSTEM 04/26/06 Crystal structure of the Fv fragment of a monoclonal antibody specific for poly-glutamine MUS MUSCULUS mus musculus mus musculus Li, P., Huey-Tubman, K.E., West Jr., A.P., Bennett, M.J., Bjorkman, P.J. 2.1 X-RAY DIFFRACTION 0.253 0.229 False True IGHV5 IGLV3 Lambda None None None None None 6x3s K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 5u3d B A 0 E protein protein l IMMUNE SYSTEM 12/01/16 STRUCTURE OF MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS homo sapiens homo sapiens finegoldia magna Bzymek, K.P., Avery, K.N., Zer, C., Williams, J.C. 1.77 X-RAY DIFFRACTION 0.185 0.157 False True IGHV3 IGKV1 Kappa None None None None None 6nf2 E F 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 6lxj H L 0 A protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9) INFLUENZA A VIRUS (A/ANHUI/1-BALF_RG44/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1-balf_rg44/2013(h7n9)) Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 2.903 X-RAY DIFFRACTION 0.241 0.193 False True IGHV1 IGLV2 Lambda None None None None None 1y0l H L 0 H Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/15/04 Catalytic elimination antibody 34E4 in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.239 0.204 False True IGHV4 IGLV1 Lambda 1e-09 -12.27819680469229 Unknown TBD 3jau H L 0 A peptide capsid protein vp1 VIRUS/IMMUNE SYSTEM 06/24/15 The cryoEM map of EV71 mature viron in complex with the Fab fragment of antibody D5 HUMAN ENTEROVIRUS human enterovirus human enterovirus human enterovirus Fan, C., Ye, X.H., Ku, Z.Q., Zuo, T., Kong, L.L., Zhang, C., Shi, J.P., Liu, Q.W., Chen, T., Zhang, Y.Y., Jiang, W., Zhang, L.Q., Huang, Z., Cong, Y. 4.8 ELECTRON MICROSCOPY False False IGHV14 IGKV1 Kappa None None None None None 5wdu C B 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True IGHV4 unknown unknown None None None None None 6jod H L 0 A | C protein | protein NA | NA type-2 angiotensin ii receptor | soluble cytochrome b562,soluble cytochrome b562 SIGNALING PROTEIN 03/20/19 Angiotensin II type 2 receptor with ligand HOMO SAPIENS; ESCHERICHIA COLI; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | escherichia coli Asada, H., Iwata, S., Hirata, K., Shimamura, T. 3.2 X-RAY DIFFRACTION 0.287 0.235 False False IGHV5 IGKV4 Kappa None None None None None 6cxc I K 0 F | E protein | protein NA | NA fusion glycoprotein f0, envelope glycoprotein chimera | fusion glycoprotein f0, envelope glycoprotein chimera VIRAL PROTEIN/IMMUNE SYSTEM 04/02/18 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus fusion protein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN IMMUNODEFICIENCY VIRUS 1 mus musculus mus musculus human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 | human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Xie, Q., Wang, Z., Chen, X., Ni, F., Ma, J., Wang, Q. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 6mb3 C N 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 4yc2 H L 0 G protein the stabilized inner domain of clade a/e hiv-1 gp120 frome. coli VIRAL PROTEIN/IMMUNE SYSTEM 02/19/15 Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 from E. coli in complex with the antibody A32. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 3.02 X-RAY DIFFRACTION 0.288 0.227 False True IGHV4 IGLV2 Lambda None None None None None 7vug S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/02/21 Cryo-EM structure of a class A orphan GPCR in complex with Gi HOMO SAPIENS; BACILLUS CIRCULANS homo sapiens homo sapiens | homo sapiens | homo sapiens Liu, Z.J., Hua, T., Zhou, Y.L., Wu, L.J. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6yxf H h 0 A protein NA adiponectin receptor protein 2 MEMBRANE PROTEIN 05/01/20 Cryogenic human adiponectin receptor 2 (ADIPOR2) with Gd-DO3 ligand determined by Serial Crystallography (SSX) using CrystalDirect HOMO SAPIENS homo sapiens homo sapiens Healey, R.D., Basu, S., Humm, A.S., Leyrat, C., Dupeux, F., Pica, A., Granier, S., Marquez, J.A. 3.025 X-RAY DIFFRACTION 0.259 0.214 True True unknown unknown unknown None None None None None 5niv B A 0 IMMUNE SYSTEM 03/27/17 Crystal structure of 5D3 Fab MUS MUSCULUS mus musculus mus musculus Manolaridis, I., Locher, K.P. 1.498 X-RAY DIFFRACTION 0.205 0.181 False False IGHV3 IGKV13 Kappa None None None None None 7u2e H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/23/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADI-55688 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.85 X-RAY DIFFRACTION 0.284 0.254 False True IGHV3 IGLV1 Lambda None None None None None 3fn0 H L 0 P peptide envelope polyprotein gp160 IMMUNE SYSTEM 12/22/08 Crystal structure of HIV-1 neutralizing human Fab Z13e1 in complex with a 12-residue peptide containing the Z13e1 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Pejchal, R., Wilson, I.A., Zwick, M.B. 1.8 X-RAY DIFFRACTION 0.252 0.210 False True IGHV4 IGKV3D Kappa 3.9999999999999996e-05 -5.99986366241171 Unknown TBD 7ll2 I J 0 C protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/03/21 Cryo-EM structure of BG505 DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody VRC33.01 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6rcv H G 0 F protein reticulocyte binding protein homologue 5 CELL ADHESION 04/11/19 PfRH5 bound to monoclonal antibodies R5.011 and R5.016 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Alanine, D.W.G., Draper, S.J., Higgins, M.K. 3.582 X-RAY DIFFRACTION 0.305 0.280 False True IGHV7 IGLV3 Lambda None None None None None 7tow H L 0 E peptide NA spike protein s2 IMMUNE SYSTEM/Viral Protein 01/24/22 Antibody DH1058 Fab fragment bound to SARS-CoV-2 fusion peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gobeil, S., Acharya, P. 2.15 X-RAY DIFFRACTION 0.234 0.167 False True IGHV3 IGKV1 Kappa None None None None None 3k7u A NA 0 C protein mp18 rna editing complex protein Immune System, RNA Binding Protein 10/13/09 Structure of essential protein from Trypanosoma brucei LAMA GLAMA; TRYPANOSOMA BRUCEI lama glama trypanosoma brucei Wu, M. 2.1 X-RAY DIFFRACTION 0.265 0.202 False True IGHV1 None None None None None 6gs7 H NA 0 A protein dipeptide and tripeptide permease a MEMBRANE PROTEIN 06/13/18 Crystal structure of peptide transporter DtpA-nanobody in glycine buffer ESCHERICHIA COLI K-12; LAMA lama escherichia coli k-12 Ural-Blimke, Y., Flayhan, A., Quistgaard, E.M., Loew, C. 3.3 X-RAY DIFFRACTION 0.246 0.210 False True IGHV1 None None None None None 7v0v A NA 17 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6mqe A B 0 D peptide hiv fusion peptide IMMUNE SYSTEM 10/09/18 Vaccine-elicited NHP FP-targeting neutralizing antibody DFPH-a.15 in complex with FP (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.459 X-RAY DIFFRACTION 0.245 0.192 False True IGHV4 IGKV1 Kappa None None None None None 2vxq H L 0 A protein pollen allergen phl p 2 ALLERGEN 07/08/08 Crystal structure of the major grass pollen allergen Phl p 2 in complex with its specific IgE-Fab PHLEUM PRATENSE; HOMO SAPIENS homo sapiens homo sapiens phleum pratense Padavattan, S., Flicker, S., Schirmer, T., Madritsch, C., Randow, S., Reese, G., Vieths, S., Lupinek, C., Ebner, C., Rudolf, V., Markovic-Housley, Z. 1.9 X-RAY DIFFRACTION 0.226 0.177 False True IGHV4 IGKV1 Kappa 1.10e-10 -13.58 SPR 25 19201867 4j8r D C 0 J peptide major prion protein IMMUNE SYSTEM 02/14/13 Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Swayampakula, M., Baral, P.K., Kav, N.N.V., Aguzzi, A., James, M.N.G. 2.303 X-RAY DIFFRACTION 0.257 0.247 False False IGHV1 IGKV6 Kappa 2e-08 -10.503274322962254 Unknown TBD 4o5i U V 0 I protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 6.501 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 IGLV1 Lambda None None None None None 6ocd B NA 0 A protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V6D4 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 2.103 X-RAY DIFFRACTION 0.228 0.189 False True IGHV1 None None None None None 4jo3 I M 0 Q peptide gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/16/13 Crystal structure of rabbit mAb R20 Fab in complex with V3 C-terminus of HIV-1 Consensus B gp120 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R.M., Kong, X.P. 2.6 X-RAY DIFFRACTION 0.234 0.184 False True IGHV1 IGKV1 Kappa None None None None None 6ozc J M 0 E carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN 05/20/20 BG505 SOSIP.664 with 2G12 Fab2 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.79 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 3vi4 H L 0 D protein integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 09/21/11 Crystal structure of alpha5beta1 integrin headpiece in complex with RGD peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Nagae, M., Nogi, T., Takagi, J. 2.9 X-RAY DIFFRACTION 0.275 0.215 False True IGHV1 IGKV2 Kappa None None None None None 5ywo R Q 0 A protein NA jev e protein VIRUS 11/29/17 Structure of JEV-2F2 Fab complex JAPANESE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus japanese encephalitis virus Qiu, X., Lei, Y.F., Yang, P., Gao, Q., Wang, N., Cao, L., Yuan, S., Wang, X., Xu, Z.K., Rao, Z. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV3 Kappa None None None None None 1xcq D C 0 Q | M peptide | protein NA | NA capsid protein c | protein l IMMUNE SYSTEM 09/03/04 Complex HCV core-Fab 19D9D6-Protein L mutant (D55A,L57H,Y64W) in space group P21 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | finegoldia magna Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 3.5 X-RAY DIFFRACTION 0.264 0.192 False False IGHV9 IGKV8 Kappa None None None None None 6um5 G H 0 E protein ch848 10.17 dt gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunders, K.O., Haynes, B.F. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7wwm H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/13/22 S protein of Delta variant in complex with ZWC6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6t9d A B 0 D protein NA unknown IMMUNE SYSTEM 10/28/19 Crystal structure of a bispecific DutaFab in complex with human VEGF121 HOMO SAPIENS Kimbung, R., Logan, D.T., Beckmann, R., Jensen, K., Speck, J., Fenn, S., Kettenberger, H. 2.905 X-RAY DIFFRACTION 0.280 0.212 False False IGHV3 IGKV1 Kappa None None None None None 7m8l I L 0 C protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 03/30/21 EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 3whe U V 0 E protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 4nzt H L 0 M protein protein m td PROTEIN BINDING/IMMUNE SYSTEM 12/12/13 Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-infleunza hemagglutinin antibody CR9114 Fab MYCOPLASMA GENITALIUM; HOMO SAPIENS homo sapiens homo sapiens mycoplasma genitalium Zhu, X., Wilson, I.A. 2.497 X-RAY DIFFRACTION 0.246 0.177 False True IGHV1 IGLV1 Lambda None None None None None 1vhp A NA 11 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4gmt H L 0 IMMUNE SYSTEM 08/16/12 Crystal structure of heterosubtypic Fab S139/1 MUS MUSCULUS mus musculus mus musculus Lee, P.S., Ekiert, D.C., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.209 0.158 False True IGHV1 IGKV6 Kappa None None None None None 1jrh H L 0 I protein interferon-gamma receptor alpha chain COMPLEX (ANTIBODY/ANTIGEN) 09/23/97 COMPLEX (ANTIBODY/ANTIGEN) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Winkler, F.K., Sogabe, S. 2.8 X-RAY DIFFRACTION 0.314 0.246 False False IGHV8 IGKV13 Kappa 1.42e-08 -10.7 SPR 25 9367779 4wuk H L 0 IMMUNE SYSTEM 11/01/14 Crystal structure of apo CH65 Fab HOMO SAPIENS homo sapiens homo sapiens Lee, P.S., Wilson, I.A. 1.7 X-RAY DIFFRACTION 0.207 0.181 False True IGHV1 IGLV3 Lambda None None None None None 1mch NA A 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-b-ala-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 4nc1 C NA 0 A protein cell wall-binding repeat protein IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A2 Bound to A20.1 VHH and A26.8 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 2.61 X-RAY DIFFRACTION 0.252 0.202 False True IGHV1 None None None None None 4xvj H L 0 A peptide hcv e2 antigen IMMUNE SYSTEM 01/27/15 STUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC 2 REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC33.1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Li, Y., Mariuzza, R.A. 2.0 X-RAY DIFFRACTION 0.274 0.225 False True IGHV3 IGLV1 Lambda None None None None None 6q1k H L 0 IMMUNE SYSTEM 08/05/19 Inferred intermediate I-7 of the human antibody lineage 652 HOMO SAPIENS homo sapiens homo sapiens McCarthy, K.R., Harrison, S.C. 2.2 X-RAY DIFFRACTION 0.239 0.191 False True IGHV4 IGLV3 Lambda None None None None None 6nha H L 0 A | B protein | protein NA | NA igg receptor fcrn large subunit p51 | beta-2-microglobulin IMMUNE SYSTEM 12/21/18 Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Blumberg, R.S., Cheung, J., Mahmood, A., Gandhi, A.K. 2.381 X-RAY DIFFRACTION 0.245 0.190 False True IGHV1 IGKV13 Kappa None None None None None 7u2d H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/23/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADG20 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, X., Yuan, M., Wilson, I.A. 2.76 X-RAY DIFFRACTION 0.259 0.220 False True IGHV3 IGLV1 Lambda None None None None None 6pi7 F E 0 D protein tudor and kh domain-containing protein PROTEIN BINDING 06/26/19 Crystal structure of the TDRD2 extended Tudor domain in complex with an antibody fragment and the PIWIL1 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, K., Min, J.R., Structural Genomics Consortium (SGC) 2.8 X-RAY DIFFRACTION 0.206 0.190 False True IGHV3 IGKV1 Kappa None None None None None 6k2i A NA 9 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 4ios F NA 0 C protein NA bpp VIRAL PROTEIN 01/08/13 Structure of phage TP901-1 RBP (ORF49) in complex with nanobody 11. LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 Desmyter, A., Farenc, C., Mahony, J., Spinelli, S., Bebeacua, C., Blangy, S., Veesler, D., van Sinderen, D., Cambillau, C. 2.4 X-RAY DIFFRACTION 0.227 0.201 False True IGHV1 NA NA None None None None None 7mkm H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/24/21 SARS-CoV-2 Spike RBD in complex with neutralizing Fab SARS2-38 (local refinement) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Adams, L.J., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.16 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV4 Kappa None None None None None 7zff H L 0 NA NA NA NA IMMUNE SYSTEM 04/01/22 Omi-42 Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Huo, J., Ren, J., Stuart, D.I. 2.32 X-RAY DIFFRACTION 0.269 0.231 False True IGHV3 IGLV2 Lambda None None None None None 6b3k H L 0 R nucleic-acid rna (83-mer),rna (83-mer) Immuny system/RNA 09/22/17 Spinach RNA aptamer_AGACC mutant-Fab BL3-6 complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct DasGupta, S., Koirala, D., Shelke, S.A., Piccirilli, J.A. 2.09 X-RAY DIFFRACTION 0.226 0.193 False True IGHV3 IGKV1 Kappa 1.2000000000000002e-07 -9.441686078959169 Unknown TBD 4ygv A B 0 IMMUNE SYSTEM 02/26/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens Schiele, F., Nar, H. 1.76 X-RAY DIFFRACTION 0.198 0.178 False True IGHV1 IGKV1 Kappa None None None None None 5aum H L 0 C peptide peptide renlyfqgkdg IMMUNE SYSTEM/PEPTIDE 04/30/15 Crystal structure of a Fab fragment with the ligand peptide RATTUS; SYNTHETIC CONSTRUCT rattus rattus potyviridae Kitago, Y., Takagi, J. 2.05 X-RAY DIFFRACTION 0.221 0.189 False True IGHV10 IGKV2 Kappa None None None None None 7tpg H L 0 B protein NA putative cell surface polysaccharide polymerase/ligase MEMBRANE PROTEIN 01/25/22 Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its ligand bound state CUPRIAVIDUS METALLIDURANS; HOMO SAPIENS homo sapiens homo sapiens cupriavidus metallidurans Ashraf, K.U., Nygaard, R., Vickery, O.N., Erramilli, S.K., Herrera, C.M., McConville, T.H., Petrou, V.I., Giacometti, S.I., Dufrisne, M.B., Nosol, K., Zinkle, A.P., Graham, C.L.B., Loukeris, M., Kloss, B., Skorupinska-Tudek, K., Swiezewska, E., Roper, D., Clarke, O.B., Uhlemann, A.C., Kossiakoff, A.A., Trent, M.S., Stansfeld, P.J., Mancia, F. 3.23 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5xs7 H L 0 A protein genome polyprotein VIRUS 06/12/17 Structure of Coxsackievirus A6 (CVA6) virus A-particle in complex with the neutralizing antibody fragment 1D5 MUS MUSCULUS; COXSACKIEVIRUS A6 mus musculus mus musculus coxsackievirus a6 Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Li, S.W., Cheng, T. 3.8 ELECTRON MICROSCOPY False False IGHV5 IGKV6 Kappa None None None None None 6xzf B NA 0 A protein NA egfp IMMUNE SYSTEM 02/04/20 Nanobody in complex with eGFP LAMA GLAMA; AEQUOREA VICTORIA lama glama aequorea victoria Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.8 X-RAY DIFFRACTION 0.204 0.173 False True IGHV1 NA NA None None None None None 7r4r D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/09/22 The SARS-CoV-2 spike in complex with the 1.10 neutralizing nanobody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Melero, R., Arranz, R., Fernandez, L.A. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5omn C NA 0 B protein capsid protein VIRAL PROTEIN 08/01/17 GII.10 Vietnam 026 protruding domain in complex with Nanobody Nano-27 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, G.S. 2.682 X-RAY DIFFRACTION 0.263 0.235 False True IGHV1 9.5e-09 -10.944343155100093 ITC TBD 5wtt A B 0 C peptide epitope peptide of cyr61 PROTEIN BINDING 12/14/16 Structure of the 093G9 Fab in complex with the epitope peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens homo sapiens Zhong, C., Hu, K., Shen, J., Ding, J. 2.7 X-RAY DIFFRACTION 0.274 0.222 False True IGHV3 IGKV1 Kappa 2.5e-07 -9.006821321101087 Unknown TBD 5tud C B 0 A protein 5-hydroxytryptamine receptor 2b,soluble cytochrome b562chimera SIGNALING PROTEIN 11/05/16 Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody HOMO SAPIENS; ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus homo sapiens, escherichia coli Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G.W., Basu, S., Boutet, S., James, D., Wang, D., Weierstall, U., Liu, W., Katritch, V., Stevens, R.C., Cherezov, V. 3.0 X-RAY DIFFRACTION 0.247 0.227 False True IGHV1 IGKV4 Kappa None None None None None 7dk4 e f 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/23/20 S-2H2-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 6idk I J 0 E protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 5.0 (Class I particle) DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 25 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 5w9k B C 0 A protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.6 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 4k3h NA F 0 E Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 4rgn D E 0 A protein enterotoxin type b TOXIN/IMMUNE SYSTEM 09/30/14 Structure of Staphylococcal Enterotoxin B bound to two neutralizing antibodies, 14G8 and 6D3 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Franklin, M.C., Dutta, K., Varshney, A.K., Goger, M.J., Fries, B.C. 2.698 X-RAY DIFFRACTION 0.278 0.240 False False IGHV1 IGKV8 Kappa None None None None None 5xcv A B 0 C peptide pa14 peptide IMMUNE SYSTEM 03/23/17 Crystal structure of NZ-1 Fv-clasp fragment with its antigen peptide RATTUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT rattus, homo sapiens rattus, homo sapiens homo sapiens Arimori, T., Takagi, J. 2.143 X-RAY DIFFRACTION 0.277 0.228 False True IGHV5 IGLV3 Lambda None None None None None 7kgv C E 0 B protein NA sodium-coupled neutral amino acid transporter 9 TRANSPORT PROTEIN 10/19/20 Crystal structure of sodium-coupled neutral amino acid transporter SLC38A9 in the N-terminal plugged form DANIO RERIO; MUS MUSCULUS mus musculus mus musculus danio rerio Lei, H., Mu, X., Hattne, J., Gonen, T. 3.4 X-RAY DIFFRACTION 0.284 0.251 False False unknown unknown unknown None None None None None 4dcq B A 0 IMMUNE SYSTEM 01/18/12 Crystal Structure of the Fab Fragment of 3B5H10, an Antibody-Specific for Extended Polyglutamine Repeats (orthorhombic form) MUS MUSCULUS mus musculus mus musculus Peters-Libeu, C.A., Tran, T., Finkbeiner, S., Weisgraber, K. 1.94 X-RAY DIFFRACTION 0.246 0.185 False False IGHV9 IGLV3 Lambda None None None None None 5kem I J 0 F protein ebola secreted glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91 HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 5.5 ELECTRON MICROSCOPY False True IGHV8 IGKV6 Kappa None None None None None 6lz2 D NA 0 C protein NA thermostable green fluorescent protein FLUORESCENT PROTEIN 02/17/20 Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb44) GALAXEA FASCICULARIS; LAMA GLAMA lama glama galaxea fascicularis Cai, H., Yao, H., Li, T., Hutter, C., Tang, Y., Li, Y., Seeger, M., Li, D. 2.03 X-RAY DIFFRACTION 0.215 0.175 False True IGHV1 NA NA None None None None None 4rav A B 0 E peptide huntingtin IMMUNE SYSTEM/Apoptosis 09/11/14 Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens De Genst, E., Chirgadze, D.Y., Dobson, C.M. 2.5 X-RAY DIFFRACTION 0.226 0.180 False True IGHV3 IGLV2 Lambda None None None None None 4xvu I J 0 H protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/28/15 Structure of Get3 bound to the transmembrane domain of Nyv1 SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE; HOMO SAPIENS, SYNTHETIC CONSTRUCT homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.35 X-RAY DIFFRACTION 0.234 0.197 False True IGHV3 IGKV1 Kappa None None None None None 2ymx H L 0 10/10/12 Crystal structure of inhibitory anti-AChE Fab408 MUS MUSCULUS mus musculus mus musculus Bourne, Y., Renault, L., Essono, S., Mondielli, G., Lamourette, P., Bocquet, D., Grassi, J., Marchot, P. 1.9 X-RAY DIFFRACTION 0.25353 0.20845 False False IGHV1 IGKV12 Kappa None None None None None 2hff H L 0 IMMUNE SYSTEM 06/23/06 Crystal structure of CB2 Fab HOMO SAPIENS homo sapiens homo sapiens Hymowitz, S.G. 1.95 X-RAY DIFFRACTION 0.221 0.189 False True IGHV3 IGKV1 Kappa None None None None None 3gi8 H L 0 C protein uncharacterized protein mj0609 TRANSPORT PROTEIN 03/05/09 Crystal Structure of ApcT K158A Transporter Bound to 7F11 Monoclonal Fab Fragment METHANOCALDOCOCCUS JANNASCHII; MUS MUSCULUS mus musculus mus musculus methanocaldococcus jannaschii Shaffer, P.L., Goehring, A.S., Shankaranarayanan, A., Gouaux, E., New York Consortium on Membrane Protein Structure (NYCOMPS) 2.59 X-RAY DIFFRACTION 0.307 0.254 False True IGHV1 IGKV8 Kappa None None None None None 5uby H L 0 IMMUNE SYSTEM 12/21/16 Fab structure of anti-HIV-1 gp120 mAb 1A8 HOMO SAPIENS homo sapiens homo sapiens Pan, R., Kong, X.-P. 2.6 X-RAY DIFFRACTION 0.249 0.188 False True IGHV4 IGLV3 Lambda None None None None None 6uyd H L 0 E protein envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C HEPATITIS C VIRUS (ISOLATE H); HOMO SAPIENS homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Zhu, J. 1.897 X-RAY DIFFRACTION 0.243 0.208 False True IGHV1 IGKV3 Kappa None None None None None 5lhr B NA 0 A protein urokinase-type plasminogen activator HYDROLASE 07/12/16 The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22 MUS MUSCULUS; VICUGNA PACOS vicugna pacos mus musculus Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A. 2.3 X-RAY DIFFRACTION 0.243 0.188 False True IGHV1 None None None None None 1a7r H L 0 IMMUNOGLOBULIN 03/16/98 FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) VARIANT CHAIN L GLU81->ASP MUS MUSCULUS mus musculus mus musculus Marks, C., Henrick, K., Winter, G. 2.01 X-RAY DIFFRACTION unknown 0.170 False True IGHV2 IGKV12 Kappa None None None None None 5u15 A B 0 IMMUNE SYSTEM 11/27/16 Crystal Structure of DH270.UCA3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.26 X-RAY DIFFRACTION 0.255 0.216 False True IGHV1 IGLV2 Lambda None None None None None 5bk2 H L 0 A protein maltose-binding periplasmic protein SUGAR BINDING PROTEIN 09/12/17 Crystal structure of maltose binding protein in complex with a peristeric synthetic antibody ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Mukherjee, S., Kossiakoff, A.A. 2.6 X-RAY DIFFRACTION 0.259 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6bzu A B 0 J peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Kong, L., Wilson, I.A., Law, M. 2.7 X-RAY DIFFRACTION 0.290 0.265 False True IGHV3 IGKV3 Kappa None None None None None 1bjm NA B 0 IMMUNOGLOBULIN 05/26/95 LOC NAKS, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN NAKSO4 HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.2 X-RAY DIFFRACTION unknown unknown False False IGLV1 Lambda None None None None None 7klg H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 10/30/20 SARS-CoV-2 RBD in complex with Fab 15033 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 3.2 X-RAY DIFFRACTION 0.290 0.271 False True IGHV3 IGKV1 Kappa None None None None None 7zmn K NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-048 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.2 X-RAY DIFFRACTION 0.275 0.242 False True IGHV1 NA NA None None None None None 6xw7 C NA 0 A protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5829 and glycochenodeoxycholate (GCDCA) MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 2.15 X-RAY DIFFRACTION 0.215 0.171 False True IGHV1 None None None None None 7ndc F G 0 A protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-159 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4ebq H L 0 IMMUNE SYSTEM 03/23/12 Fab structure of anti-Vaccinia virus D8L antigen mouse IgG2a LA5 MUS MUSCULUS mus musculus mus musculus Matho, M.H., Zajonc, D.M. 1.6 X-RAY DIFFRACTION 0.229 0.198 False True IGHV1 IGKV4 Kappa None None None None None 7p7a D NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#68 in a 2up/1flexible conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 4.76 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7qia B NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/14/21 Structure of apo-EleNRMT in complex with two nanobodies at 3.5A EGGERTHELLA LENTA; SYNTHETIC CONSTRUCT synthetic construct eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7e88 A B 0 C protein NA spike protein s1 VIRAL PROTEIN,IMMUNE SYSTEM 03/01/21 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-515 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, C., Wei, Y., Xiao, J. 3.14 X-RAY DIFFRACTION 0.255 0.217 False True IGHV3 IGKV1 Kappa None None None None None 7so5 H L 0 A protein NA toxin b TOXIN/IMMUNE SYSTEM 10/29/21 Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B HOMO SAPIENS; CLOSTRIDIOIDES DIFFICILE R20291 homo sapiens homo sapiens clostridioides difficile r20291 Liu, J. 1.797 X-RAY DIFFRACTION 0.223 0.185 False True IGHV4 IGKV2 Kappa None None None None None 6ot1 H L 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 4h0h B b 0 D peptide peptide IMMUNE SYSTEM 09/08/12 Crystal structure of mimicry-recognizing 2D10 scFv with peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus Tapryal, S., Gaur, V., Kaur, K.J., Salunke, D.M. 2.0 X-RAY DIFFRACTION 0.215 0.195 True True unknown unknown unknown None None None None None 7qbe E NA 0 A protein NA transcobalamin-2 TRANSPORT PROTEIN 11/19/21 TC:CD320 in complex with nanobody TC-Nb11 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Bloch, J.S., Locher, K.P. 3.0 X-RAY DIFFRACTION 0.284 0.252 False True IGHV1 NA NA None None None None None 7d8b D NA 0 C protein NA eukaryotic translation initiation factor 4e RNA BINDING PROTEIN 10/07/20 Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways HOMO SAPIENS homo sapiens homo sapiens Frosi, Y., Lin, Y.C., Jiang, S., Brown, C.J. 2.46 X-RAY DIFFRACTION 0.292 0.250 False True IGHV3 NA NA None None None None None 7s8h H L 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 09/17/21 Structure of Lassa virus glycoprotein bound to Fab 18.5C and Fab 36.1F LASSA VIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa virus Hastie, K.M., Enriquez, A.S. 2.7 X-RAY DIFFRACTION 0.251 0.218 False True IGHV3 IGKV3 Kappa None None None None None 6wos H L 0 NA NA NA NA IMMUNE SYSTEM 04/25/20 Structure of broadly neutralizing antibody AR3B HOMO SAPIENS homo sapiens homo sapiens Tzarum, N., Wilson, I.A., Law, M. 1.645 X-RAY DIFFRACTION 0.232 0.194 False True IGHV1 IGKV3 Kappa None None None None None 5tzu H L 0 C protein leukocyte surface antigen cd47 IMMUNE SYSTEM 11/22/16 Crystal structure of human CD47 ECD bound to Fab of B6H12.2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cardoso, R.M.F. 2.1 X-RAY DIFFRACTION 0.213 0.177 False True IGHV5 IGKV5 Kappa None None None None None 5w9i C D 0 A protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6kn9 F f 0 C protein interleukin-18 receptor accessory protein CYTOKINE 08/05/19 Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv HOMO SAPIENS homo sapiens homo sapiens Wu, D.H., Liu, C.C. 3.302 X-RAY DIFFRACTION 0.277 0.247 True True unknown unknown unknown None None None None None 4zff A B 0 C protein vascular endothelial growth factor a SIGNALING PROTEIN/IMMUNE SYSTEM 04/21/15 Dual-acting Fab 5A12 in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Harris, S.F., Wu, P. 2.75 X-RAY DIFFRACTION 0.238 0.197 False True IGHV3 IGKV1 Kappa 5e-09 -11.324631107601816 SPR TBD 6gff N M 0 J | G | H protein | protein | protein NA | NA | NA leucine-rich repeat-containing protein 32 | transforming growth factor beta-1 | transforming growth factor beta-1 IMMUNE SYSTEM 04/30/18 Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Merceron, R., Lienart, S., Vanderaa, C., Colau, D., Stockis, J., Van Der Woning, B., De Haard, H., Saunders, M., Coulie, P.G., Savvides, S.N., Lucas, S. 3.1 X-RAY DIFFRACTION 0.268 0.233 False False IGHV2 IGKV13 Kappa None None None None None 1g9e A NA 4 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7cjf A B 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/10/20 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Li, X., Zhang, G., Fu, D., Schweizer, L., Zhang, H., Rao, Z. 2.108 X-RAY DIFFRACTION 0.229 0.185 False True IGHV3 IGKV1 Kappa None None None None None 7m8l M P 0 D protein NA virion spike glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/30/21 EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 5jw4 W X 0 L | K protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment in Complex with H5 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 3.7 X-RAY DIFFRACTION 0.285 0.274 False True IGHV6 IGKV1 Kappa None None None None None 4z7q H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 MEMBRANE PROTEIN/IMMUNE SYSTEM 04/07/15 Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Lin, F.-Y., Zhu, J., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.236 0.188 False True IGHV14 IGKV14 Kappa None None None None None 6b6z D C 0 IMMUNE SYSTEM 12/19/18 Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains) HOMO SAPIENS homo sapiens homo sapiens Radwanska, M.J., Derewenda, U., Kossiakoff, A.A., Derewenda, Z.S. 2.112 X-RAY DIFFRACTION 0.258 0.203 False True IGHV3 IGKV1 Kappa None None None None None 6wzt E D 0 B protein NA hemagglutinin ANTIVIRAL PROTEIN 05/14/20 CryoEM structure of influenza hemagglutinin A/Victoria/361/2011 in complex with cyno antibody 3B10 INFLUENZA A VIRUS; MACACA FASCICULARIS macaca fascicularis macaca fascicularis influenza a virus Qiu, Y., Zhou, Y., Darricarrere, N. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5m94 D NA 0 C protein divalent metal cation transporter mnth TRANSPORT PROTEIN 10/31/16 Crystal structure of Staphylococcus capitis divalent metal ion transporter (DMT) in complex with nanobody STAPHYLOCOCCUS CAPITIS; LAMA GLAMA lama glama staphylococcus capitis Dutzler, R., Ehrnstorfer, I.A. 3.101 X-RAY DIFFRACTION 0.273 0.237 False True IGHV1 None None None None None 6orq H L 0 G protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 6p3s V W 0 X protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 5kzp G K 0 D peptide c1 epitope VIRAL PROTEIN/IMMUNE SYSTEM 07/25/16 Structure of the HCV1-C1 Antibody-Antigen Complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Piepenbrink, K.H., Sundberg, E.J. 2.262 X-RAY DIFFRACTION 0.261 0.218 False True IGHV3 IGKV3 Kappa 7e-08 -9.761032709220395 Unknown TBD 6ul6 B NA 0 A protein bont/a TOXIN/ANTITOXIN 10/07/19 Crystal Structure of BoNT/A-LCHn domain in complex with VNA ciA-D12/11/ciA-B5 and VHH ciA-H7 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.02 X-RAY DIFFRACTION 0.194 0.183 False True IGHV1 None None None None None 7tbf H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/21 Locally refined region of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5wdf H L 0 P peptide hiv-1 gp41 peptide IMMUNE SYSTEM 07/05/17 Crystal structure of 10E8v4-5R+100cF Fab in complex with HIV-1 gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.281 0.247 False True IGHV3 IGLV3 Lambda None None None None None 4lve NA B 0 IMMUNOGLOBULIN 05/12/98 LEN K30T MUTANT: A DOMAIN FLIP AS A RESULT OF A SINGLE AMINO ACID SUBSTITUTION HOMO SAPIENS homo sapiens Schiffer, M., Pokkuluri, P.R. 2.3 X-RAY DIFFRACTION 0.267 0.190 False True IGKV4 Kappa None None None None None 1shm D NA 0 IMMUNE SYSTEM 02/26/04 Convergent solutions to VHH domain stabilization from natural and in vitro evolution LAMA GLAMA lama glama Bond, C.J., Wiesmann, C., Marsters, J.C., Sidhu, S.S. 1.9 X-RAY DIFFRACTION 0.236 0.185 False True IGHV1 None None None None None 7p40 C D 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/09/21 P5C3 is a potent fab neutralizer SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 perez, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4k8r D C 0 B protein proprotein convertase subtilisin/kexin type 9 IMMUNE SYSTEM 04/18/13 An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schiele, F., Nar, H. 3.22 X-RAY DIFFRACTION 0.226 0.167 False True IGHV3 IGKV1 Kappa None None None None None 2j5l C B 0 A peptide apical membrane antigen 1 IMMUNE SYSTEM 09/18/06 Structure of a Plasmodium falciparum apical membrane antigen 1-Fab F8. 12.19 complex PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Igonet, S., Vulliez-Le Normand, B., Faure, G., Riottot, M.M., Kocken, C., Thomas, A.W., Bentley, G.A. 2.9 X-RAY DIFFRACTION 0.278 0.212 False False IGHV5 IGKV4 Kappa 7.70e-08 -9.7 SPR 17229439 7p77 A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6hhd B NA 0 A protein major prion protein PROTEIN BINDING 08/28/18 Mouse Prion Protein in complex with Nanobody 484 MUS MUSCULUS; CAMELUS DROMEDARIUS camelus dromedarius mus musculus Soror, S., Abskharon, R., Wohlkonig, A. 2.102 X-RAY DIFFRACTION 0.245 0.206 False True IGHV1 None None None None None 7ktx I J 0 A protein NA er membrane protein complex subunit 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/24/20 Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to a Fab in DDM detergent HOMO SAPIENS; SACCHAROMYCES CEREVISIAE BY4743 homo sapiens homo sapiens saccharomyces cerevisiae by4743 Miller-Vedam, L.E., Schirle Oakdale, N.S., Braeuning, B., Boydston, E.A., Sevillano, N., Popova, K.D., Bonnar, J.L., Shurtleff, M.J., Prabu, J.R., Stroud, R.M., Craik, C.S., Schulman, B.A., Weissman, J.S., Frost, A. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 7v26 e f 0 E protein NA xg005 heavy chain VIRAL PROTEIN 08/07/21 XG005-bound SARS-CoV-2 S SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Sun, L., Chen, Z.G. 3.85 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 3lhp I M 0 T protein 4e10_d0_1isea_004_n (t93) IMMUNE SYSTEM 01/22/10 Crystal structure of HIV epitope-scaffold 4E10_D0_1ISEA_004_N 4E10 Fv complex HOMO SAPIENS; ARTIFICIAL GENE homo sapiens homo sapiens artificial gene Holmes, M.A. 2.7 X-RAY DIFFRACTION 0.335 0.243 False True IGHV1 IGKV3 Kappa 7.50e-12 -15.17 SPR 20826338 7lx5 C NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/03/21 The SARS-CoV-2 spike protein receptor binding domain bound to neutralizing nanobodies WNb 2 and WNb 10 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Pymm, P., Glukhova, A., Tham, W.-H. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3j7e F E 0 IMMUNE SYSTEM 06/23/14 Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments MUS MUSCULUS mus musculus mus musculus Lee, H., Brendle, S.A., Bywaters, S.M., Christensen, N.D., Hafenstein, S. 13.6 ELECTRON MICROSCOPY False False IGHV1 IGKV8 Kappa None None None None None 5w9m H I 0 G protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.7 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6dn0 C D 0 IMMUNE SYSTEM 06/05/18 Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D. HOMO SAPIENS homo sapiens homo sapiens Langley, D.B., Roome, B., Christ, D. 2.0 X-RAY DIFFRACTION 0.234 0.205 False True IGHV3 IGKV1 Kappa None None None None None 7t0k H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 4 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.0 X-RAY DIFFRACTION 0.255 0.222 False True IGHV7 IGKV8 Kappa None None None None None 3cm9 B M 2 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 2qtj D N 3 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5i8c A B 0 C peptide hiv-1 clade a bg505 fusion peptide (residue 512-520) IMMUNE SYSTEM 02/18/16 Crystal Structure of HIV-1 Clade A BG505 Fusion Peptide (residue 512-520) in Complex with Broadly Neutralizing Antibody VRC34.01 Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Zhou, T., Liu, K., Kwong, P.D. 1.54 X-RAY DIFFRACTION 0.182 0.160 False True IGHV1 IGKV1 Kappa 2.5000000000000002e-08 -10.371065410511342 Unknown TBD 4lcu A B 0 C protein ph-gated potassium channel kcsa TRANSPORT PROTEIN, membrane protein 06/23/13 Structure of KcsA with E118A mutation STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Nimigean, C.M., Posson, D.J., McCoy, J.M. 2.752 X-RAY DIFFRACTION 0.216 0.183 False True IGHV1 IGKV5 Kappa None None None None None 5aaw B b 0 J protein dengue serotype 4 envelope protein domain 3 07/30/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency DENGUE VIRUS; MUS MUSCULUS mus musculus dengue virus Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R. 3.27 X-RAY DIFFRACTION 0.26258 0.22661 True True unknown unknown unknown 4.320000000000001e-09 -11.411241859183763 SPR TBD 6n2x M K 0 M carbohydrate NAG polysaccharide IMMUNE SYSTEM 11/14/18 Anti-HIV-1 Fab 2G12 + Man9 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.283 0.243 False True unknown IGKV1 Kappa None None None None None 2vxs I M 0 A protein interleukin-17a CYTOKINE 07/09/08 Structure of IL-17A in complex with a potent, fully human neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gerhardt, S., Hargreaves, D., Pauptit, R.A., Davies, R.A., Russell, C., Welsh, F., Tuske, S.J., Coales, S.J., Hamuro, Y., Needham, M.R.C., Langham, C., Barker, W., Bell, P., Aziz, A., Smith, M.J., Dawson, S., Abbott, W.M. 2.63 X-RAY DIFFRACTION 0.264 0.213 False True IGHV3 IGLV6 Lambda 2.10e-09 -11.83 SPR 19835883 6w51 M N 0 NA NA NA NA IMMUNE SYSTEM 03/12/20 Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Wright, K.M., Gabelli, S.B. 3.53 X-RAY DIFFRACTION 0.283 0.200 False True IGHV3 IGKV1 Kappa None None None None None 7rdw H L 0 M protein NA glycoprotein 120 IMMUNE SYSTEM 07/12/21 Crystal Structure of FH1 Fab bound to HXb2 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Weidle, C., Pancera, M. 3.55 X-RAY DIFFRACTION 0.295 0.260 False True IGHV1 IGKV3 Kappa None None None None None 6nfc J M 0 G protein NA hiv-1 env bg505 md64 n332-gt5 sosip gp41 VIRAL PROTEIN 12/19/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 7mly F K 0 D | E protein | protein NA | NA glycine receptor alpha 1 | glycine receptor beta MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa | sus scrofa Zhu, H., Gouaux, E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7lg6 H L 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/21 BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Torres, J.L., Wu, N.R., Ward, A.B. 3.28 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 3hi6 X Y 0 B protein integrin alpha-l cell adhesion/immune system 05/19/09 Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhang, H., Wang, J. 2.3 X-RAY DIFFRACTION 0.226 0.170 False True IGHV3 IGKV1 Kappa 4.70e-06 -7.26 SPR 19805116 1mjj H L 0 H Hapten HAL N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE IMMUNE SYSTEM 08/28/02 HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12 AND A TRANSITION-STATE ANALOG MUS MUSCULUS mus musculus mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 2.1 X-RAY DIFFRACTION 0.256 0.178 False True IGHV1 IGKV2 Kappa 1.83e-09 -11.920149456768272 Unknown TBD 3j8w H L 0 E protein NA l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 13 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV12 Kappa None None None None None 7d5p C NA 0 A protein NA drug transporter, putative MEMBRANE PROTEIN 09/27/20 Structure of NorC transporter in an outward-open conformation in complex with a single-chain Indian camelid antibody STAPHYLOCOCCUS AUREUS SUBSP. AUREUS COL; CAMELUS DROMEDARIUS camelus dromedarius staphylococcus aureus subsp. aureus col Kumar, S., Athreya, A., Penmatsa, A. 3.65 X-RAY DIFFRACTION 0.318 0.297 False True IGHV1 NA NA None None None None None 6dca I M 0 Q peptide microtubule-associated protein tau IMMUNE SYSTEM 05/04/18 Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 2.599 X-RAY DIFFRACTION 0.259 0.189 False False IGHV1 IGKV1 Kappa None None None None None 7myz I M 0 D protein NA fusion protein of leukocyte surface antigen cd47 an solublecytochrome b562 MEMBRANE PROTEIN 05/22/21 Structure of the full length 5-TM receptor CD47 bound to Fab B6H12 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens homo sapiens homo sapiens, escherichia coli Fenalti, G., Villanueva, N. 3.4 X-RAY DIFFRACTION 0.277 0.253 False True IGHV5 IGKV5 Kappa None None None None None 5hi5 H L 0 B protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 1.8 X-RAY DIFFRACTION 0.219 0.201 False True IGHV3 IGLV6 Lambda None None None None None 5mv3 A B 0 X peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 6pef A B 0 C peptide NA hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/20/19 Vaccine-elicited NHP FP-targeting antibody DF2F-a.01 in complex with HIV fusion peptide (residue 512-519) MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 2.004 X-RAY DIFFRACTION 0.214 0.183 False True IGHV4 IGLV1 Lambda None None None None None 6ww5 E F 0 A protein NA dass family sodium-coupled anion symporter MEMBRANE PROTEIN 05/07/20 Structure of VcINDY-Na-Fab84 in nanodisc VIBRIO CHOLERAE; HOMO SAPIENS homo sapiens homo sapiens vibrio cholerae Sauer, D.B., Marden, J., Song, J.M., Koide, A., Koide, S., Wang, D.N. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6e9h A B 0 IMMUNE SYSTEM 08/01/18 The crystal structure of bovine ultralong antibody BOV-3 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 2.0 X-RAY DIFFRACTION 0.256 0.217 False True IGHV1 IGLV1 Lambda None None None None None 5w1m D C 0 T protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 MACV GP1 CR1-07 Fab complex HOMO SAPIENS; MACHUPO VIRUS homo sapiens homo sapiens machupo virus Raymond, D.D., Clark, L.E., Abraham, J. 3.91 X-RAY DIFFRACTION 0.264 0.248 False True IGHV3 IGKV4 Kappa 1.63e-08 -10.624477030127814 SPR TBD 7tet M N 0 D | C protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in non-active2-like conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 4.45 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 6nf5 Q R 0 M protein hiv-1 env bg505 md64 n332-gt5 sosip gp41 VIRAL PROTEIN/immune system 12/18/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Steichen, J.M., Schief, W.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 7cu5 A a 0 Q protein NA programmed cell death protein 1 IMMUNE SYSTEM 08/21/20 N-Glycosylation of PD-1 and glycosylation dependent binding of PD-1 specific monoclonal antibody camrelizumab HOMO SAPIENS homo sapiens homo sapiens Liu, K.F., Tan, S.G., Jin, W.J., Guan, J.W., Wang, W.L., Sun, H., Qi, J.X., Yan, J.H., Chai, Y., Wang, Z.F., Chu, X.D., Gao, G.F. 2.81 X-RAY DIFFRACTION 0.252 0.212 True True unknown unknown unknown None None None None None 4r2g N M 0 A protein surface protein gp160 IMMUNE SYSTEM 08/11/14 Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (JRCSF ISOLATE); HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 (jrcsfisolate) Garces, F., Wilson, I.A. 3.283 X-RAY DIFFRACTION 0.263 0.207 False True IGHV4 IGLV3 Lambda 3.4e-08 -10.188885744060974 ITC TBD 6tys C D 0 B protein fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 08/09/19 A potent cross-neutralizing antibody targeting the fusion glycoprotein inhibits Nipah virus and Hendra virus infection NIPAH VIRUS; MUS MUSCULUS mus musculus mus musculus nipah virus Dang, H.V., Chan, Y.P., Park, Y.J., Snijder, J., Da Silva, S.C., Vu, B., Yan, L., Feng, Y.R., Rockx, B., Geisbert, T., Mire, C.E., Broder, C.B., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.5 ELECTRON MICROSCOPY False True IGHV5 IGKV12 Kappa None None None None None 6nf2 N M 0 A protein envelope glycoprotein gp120 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7ki4 H L 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 10/23/20 Structure of the NiV F glycoprotein in complex with the 12B2 neutralizing antibody NIPAH VIRUS; MUS MUSCULUS mus musculus mus musculus nipah virus Dang, H.V., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV12 Kappa None None None None None 7lwd H L 0 A protein NA sodium-dependent serotonin transporter TRANSPORT PROTEIN/Immune System 03/01/21 Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Kalenderoglou, I.E., Gouaux, E., Coleman, J.A., Loland, C.J. 3.65 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 4jy6 D C 0 IMMUNE SYSTEM 03/29/13 Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Diwanji, D.C., Burton, D.R., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.265 0.207 False True IGHV4 unknown unknown None None None None None 3bd5 NA B 0 IMMUNE SYSTEM 11/14/07 Crystal structure of single domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals MUS MUSCULUS mus musculus Park, S.K., Kim, J.S. 2.0 X-RAY DIFFRACTION 0.276 0.224 True True IGKV8 Kappa None None None None None 6cm3 K J 0 D protein envelope glycoprotein gp160 VIRAL PROTEIN 03/02/18 BG505 SOSIP in complex with sCD4, 17b, 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 3.54 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7kn7 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH W and antibody Fab CC12.3 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.241 0.203 False True IGHV3 IGKV3 Kappa None None None None None 7lf2 D E 0 A protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3mme A B 0 IMMUNE SYSTEM 04/19/10 Structure and functional dissection of PG16, an antibody with broad and potent neutralization of HIV-1 HOMO SAPIENS homo sapiens homo sapiens Pancera, M., McLellan, J., Zhou, T., Zhu, J., Kwong, P. 3.97 X-RAY DIFFRACTION 0.317 0.256 False True IGHV3 IGLV2 Lambda None None None None None 6b0g D C 0 E protein 25 kda ookinete surface antigen IMMUNE SYSTEM 09/14/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1245 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum McLeod, B., Scally, S.W., Bosch, A., King, C.R., Julien, J.P. 1.9 X-RAY DIFFRACTION 0.200 0.164 False True IGHV1 IGKV2 Kappa 3.1e-08 -10.243615428706017 BLI TBD 5jo5 C D 0 IMMUNE SYSTEM 05/02/16 Crystal structure of 10E8 gHV-gLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.263 0.233 False True IGHV3 IGLV3 Lambda None None None None None 5lwy H L 0 A protein adiponectin receptor protein 2 MEMBRANE PROTEIN 09/19/16 Revised crystal structure of the human adiponectin receptor 2 in complex with a C18 free fatty acid HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Leyrat, C., Vasiliauskaite-Brooks, I., Granier, S. 2.4 X-RAY DIFFRACTION 0.224 0.198 False True IGHV1 IGKV12 Kappa None None None None None 7t4q F G 0 C | E protein | protein NA | NA envelope protein ul128 | envelope protein ul131a VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with neutralizing fabs 2C12, 7I13 and 13H11 HUMAN BETAHERPESVIRUS 5; HOMO SAPIENS homo sapiens homo sapiens human betaherpesvirus 5 | human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 5v8l G K 0 C protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/22/17 BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 6plh B A 0 C peptide NA interleukin-21 receptor IMMUNE SYSTEM 06/30/19 FAB fragment complexed with C-mannosylated tryptophan peptide HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens John, A., Jarva, M.A., Goddard-Borger, E.D. 1.6 X-RAY DIFFRACTION 0.221 0.189 False False IGHV1 IGKV1 Kappa None None None None None 6udk F I 0 K protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 5wko A B 0 Q | N protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 07/25/17 Crystal structure of antibody 27F3 recognizing the HA from A/California/04/2009 (H1N1) influenza virus HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wilson, A., Lang, S., Zhu, X. 3.492 X-RAY DIFFRACTION 0.268 0.246 False True IGHV1 IGKV3 Kappa None None None None None 4lvh E F 0 D protein hemagglutinin IMMUNE SYSTEM 07/26/13 Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J.-H. 2.8 X-RAY DIFFRACTION 0.274 0.232 False False IGHV5 IGKV3 Kappa None None None None None 6bpc E F 0 D protein reticulocyte binding protein 2, putative CELL INVASION 11/22/17 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 4F7 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus mus musculus plasmodium vivax (strain salvador i) Gruszczyk, J., Chan, L.J., Tham, W.H. 2.66 X-RAY DIFFRACTION 0.215 0.197 False False IGHV5 IGKV6 Kappa None None None None None 6fy2 H L 0 P peptide cap225 scaffolded v1v2 IMMUNE SYSTEM 03/10/18 Crystal structure of a V2p-reactive RV144 vaccine-like antibody, CAP228-16H, in complex with a heterologous CAP225 V1V2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Moore, P.L., Morris, L. 2.301 X-RAY DIFFRACTION 0.217 0.190 False True IGHV5 IGLV3 Lambda None None None None None 6by2 A B 0 C protein ph-gated potassium channel kcsa MEMBRANE PROTEIN 12/19/17 Closed and deep-inactivated conformation of KcsA-T75A mutant MUS MUSCULUS; STREPTOMYCES COELICOLOR mus musculus mus musculus streptomyces coelicolor Labro, A.J., Cortes, D.M., Tilegenova, C., Cuello, L.G. 2.35 X-RAY DIFFRACTION 0.245 0.221 False True IGHV1 IGKV5 Kappa None None None None None 5hcg H NA 0 IMMUNE SYSTEM 01/04/16 CRYSTAL STRUCTURE OF FREE-CODV. HOMO SAPIENS homo sapiens Vallee, F., Dupuy, A., Rak, A. 2.68 X-RAY DIFFRACTION 0.297 0.229 False True IGHV2 None None None None None 3eyf D C 0 F peptide synthetic peptide IMMUNE SYSTEM 10/20/08 Crystal structure of anti-human cytomegalovirus antibody 8f9 plus gB peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.3 X-RAY DIFFRACTION 0.230 0.210 False True IGHV3 IGKV3 Kappa 9.40e-08 -9.3 ITC 24 18772881 6k2i A NA 10 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 6fgb H L 0 A | B protein | protein NA | NA igg receptor fcrn large subunit p51 | beta-2-microglobulin IMMUNE SYSTEM 01/10/18 Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Sarkar, K., Ceska, T., Meier, C. 2.9 X-RAY DIFFRACTION 0.284 0.232 False True IGHV3 IGKV1 Kappa 5.9e-11 -13.955054682819997 SPR TBD 6n35 M K 0 M carbohydrate MAN ALPHA-D-MANNOSE IMMUNE SYSTEM 11/14/18 Anti-HIV-1 Fab 2G12 + Man1-2 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 1.747 X-RAY DIFFRACTION 0.238 0.207 False True unknown IGKV1 Kappa None None None None None 7x8s N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/14/22 Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Cong, Z.T., Zhou, Q.T., Li, Y., Chen, L.N., Zhang, Z.C., Liang, A.Y., Liu, Q., Wu, X.Y., Dai, A.T., Xia, T., Wu, W., Zhang, Y., Yang, D.H., Wang, M.W. 3.09 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7vyt B C 0 A protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 11/15/21 Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Jeong, B.-S., Nam, H., Kim, M., Oh, B.-H. 1.53 X-RAY DIFFRACTION 0.219 0.201 False True IGHV1 IGKV3 Kappa None None None None None 7rm1 C D 0 P peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide EDGAGNQPGANGAGNQPGANGAGNQPG MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 3.19 X-RAY DIFFRACTION 0.210 0.180 False True IGHV9 IGKV8 Kappa None None None None None 3ghe H L 0 P peptide envelope glycoprotein IMMUNE SYSTEM 03/03/09 Crystal structure of anti-HIV-1 Fab 537-10D in complex with V3 peptide MN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.P., Burke, V.J. 2.4 X-RAY DIFFRACTION 0.241 0.187 False False IGHV3 IGLV2 Lambda 1.30e-06 -8.03 Other 25 19913488 7d3r H L 0 1 | 3 protein | protein NA | NA a/wh/cha/09 vp1 | a/wh/cha/09 vp3 VIRUS 09/20/20 FOOT AND MOUTH DISEASE VIRUS A/WH/CHA/09-BOUND THE SINGLE CHAIN FRAGME ANTIBODY R50 BOS TAURUS; FOOT-AND-MOUTH DISEASE VIRUS bos taurus bos taurus foot-and-mouth disease virus | foot-and-mouth disease virus He, Y., Lou, Z. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6bpd A B 0 IMMUNE SYSTEM 11/22/17 Plasmodium vivax invasion blocking monoclonal antibody 10B12 MUS MUSCULUS mus musculus mus musculus Gruszczyk, J., Chan, L.J., Tham, W.H. 2.32 X-RAY DIFFRACTION 0.262 0.211 False False IGHV1 IGKV1 Kappa None None None None None 5czv H L 0 A protein neurogenic locus notch homolog protein 3 IMMUNE SYSTEM 08/01/15 Crystal structure of Notch3 NRR in complex with 20350 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hu, T., Fryer, C., Chopra, R., Clark, K. 3.19 X-RAY DIFFRACTION 0.257 0.204 False True IGHV1 IGKV1 Kappa 3e-10 -12.991531042419238 SPR TBD 4kk6 C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of CLC-ec1 deltaNC construct in 20mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.183 X-RAY DIFFRACTION 0.269 0.235 False True IGHV4 IGKV4 Kappa None None None None None 6tkd H L 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 ChiLob 7/4 H2 HC-C228S F(ab')2 HOMO SAPIENS Orr, C.M., Fisher, H., Tews, I. 1.9 X-RAY DIFFRACTION 0.206 0.173 False False IGHV1 IGKV10 Kappa None None None None None 4llv E F 0 IMMUNE SYSTEM 07/09/13 The structure of the unbound form of anti-HIV antibody 4E10 Fv HOMO SAPIENS homo sapiens homo sapiens Finton, K.A.K., Rupert, P.B., Strong, R.K. 2.39 X-RAY DIFFRACTION 0.245 0.216 False True IGHV1 IGKV3 Kappa None None None None None 2vyr H NA 0 D protein mdm4 protein IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 1emt H L 0 IMMUNE SYSTEM 03/17/00 FAB ANTIBODY FRAGMENT OF AN C60 ANTIFULLERENE ANTIBODY MUS MUSCULUS mus musculus mus musculus Braden, B.C., Goldbaum, F.A., Chen, B.-X., Erlanger, B.F., Kirschner, A.N., Wilson, S.R. 2.25 X-RAY DIFFRACTION 0.240 0.180 False False IGHV1 IGKV10 Kappa None None None None None 6ye3 A B 0 C protein NA interleukin-2 PROTEIN BINDING 03/23/20 IL-2 in complex with a Fab fragment from UFKA-20 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Karakus, U., Mittl, P., Boyman, O. 2.89 X-RAY DIFFRACTION 0.283 0.215 False True IGHV5 IGKV8 Kappa None None None None None 4jfz H L 0 P peptide phosphopeptide immune system 02/28/13 Structure of phosphoserine (pSAb) scaffold bound to pSer peptide ESCHERICHIA COLI; SYNTHETIC CONSTRUCT Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 1.75 X-RAY DIFFRACTION 0.199 0.154 False True IGHV3 IGKV3 Kappa 7.1e-08 -9.752628544480903 Unknown TBD 2qr0 T S 0 U protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 4aiz NA B 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of 3mJL2 from the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.75 X-RAY DIFFRACTION 0.2185 0.1662 False True IGLV3 Lambda None None None None None 6cde Q R 0 C protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7cwn G F 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6zwk E NA 0 K peptide NA histone h2ax IMMUNE SYSTEM 07/28/20 Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens McEwen, A.G., Moeglin, E., Desplancq, D., Weiss, E., Poterszman, A. 1.55 X-RAY DIFFRACTION 0.184 0.149 False True IGHV1 NA NA None None None None None 7mxl H L 0 C protein NA major pollen allergen bet v 1-a ALLERGEN 05/19/21 Complex of Bet v 1 with the Fab fragments of a three antibody cocktail HOMO SAPIENS; BETULA PENDULA homo sapiens homo sapiens betula pendula Romero-Hernandez, A., Franklin, M.C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5lsp S T 0 P protein hepatocyte growth factor receptor TRANSFERASE 09/05/16 107_A07 Fab in complex with fragment of the Met receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens DiCara, D., Chirgadze, D.Y., Pope, A., Karatt-Vellatt, A., Winter, A., van den Heuvel, J., Gherardi, E., McCafferty, J. 2.605 X-RAY DIFFRACTION 0.257 0.215 False True IGHV1 IGKV1 Kappa None None None None None 7vyr A B 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/15/21 Crystal structure of SARS-CoV-2 Spike RBD in complex with the D27 neutralizing antibody Fab fragment HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jeong, B.-S., Oh, B.-H. 2.2 X-RAY DIFFRACTION 0.235 0.192 False True IGHV1 IGLV3 Lambda None None None None None 4r7d O P 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 4ydi H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 02/22/15 Crystal structure of broad and potently neutralizing VRC01-class antibody Z258-VRC27.01, isolated from human donor Z258, in complex with HIV-1 gp120 from clade A strain Q23.17 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 3.452 X-RAY DIFFRACTION 0.276 0.222 False True unknown unknown unknown None None None None None 6u3z C D 0 IMMUNE SYSTEM 08/22/19 Structure of VD20_5A4 Fab MACACA MULATTA macaca mulatta macaca mulatta Dionne, G., Shapiro, L. 1.99002 X-RAY DIFFRACTION 0.236 0.199 False True IGHV4 IGKV1 Kappa None None None None None 5j74 B b 0 b Hapten 6GN 1-(17-amino-5,8-dioxo-12,15-dioxa-4,9-diazaheptadecan-1-yl)-4-{[3-(3-sulfopropyl)-1,3-benzothiazol-3-ium-2-yl]methyl}quinolin-1-ium IMMUNE SYSTEM 04/05/16 Fluorogen activating protein AM2.2 in complex with TO1-2p HOMO SAPIENS homo sapiens Stanfield, R.L., Wilson, I.A., Wu, Y. 2.7 X-RAY DIFFRACTION 0.250 0.197 True True unknown unknown unknown 1.9e-09 -11.897908852190566 Unknown TBD 5utf D E 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 02/14/17 Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Chuang, G.-Y., Xu, K., Kwong, P.D. 3.503 X-RAY DIFFRACTION 0.299 0.216 False True unknown unknown unknown None None None None None 6iyn A NA 15 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 3w11 C D 0 E protein insulin receptor domains l1-cr HORMONE/HORMONE RECEPTOR/IMMUNE SYSTEM 11/06/12 Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Smith, B.J. 3.9 X-RAY DIFFRACTION 0.292 0.264 False True IGHV2 IGKV8 Kappa None None None None None 4nki H L 0 CYTOKINE 11/12/13 Crystal structure of a Fab HOMO SAPIENS homo sapiens homo sapiens Jiang, X. 2.41 X-RAY DIFFRACTION 0.245 0.197 False True IGHV3 IGLV2 Lambda None None None None None 6do1 C NA 0 A protein type-1 angiotensin ii receptor,soluble cytochrome b562 brilfusion protein MEMBRANE PROTEIN 06/08/18 Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8 HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT synthetic construct homo sapiens, escherichia coli Wingler, L.M., McMahon, C., Staus, D.P., Lefkowitz, R.J., Kruse, A.C. 2.901 X-RAY DIFFRACTION 0.359 0.305 False True IGHV1 None None None None None 7ki6 D C 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 10/23/20 Structure of the HeV F glycoprotein in complex with the 1F5 neutralizing antibody HENDRA HENIPAVIRUS; MUS MUSCULUS mus musculus mus musculus hendra henipavirus Dang, H.V., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 6cnk K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 03/08/18 Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Walsh Jr, R.M., Roh, S.H., Gharpure, A., Morales-Perez, C.L., Hibbs, R.E. 3.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 5mub O P 0 Q peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 5vnw C NA 0 B protein serum albumin TRANSPORT PROTEIN/DE NOVO PROTEIN 05/01/17 Crystal structure of Nb.b201 bound to human serum albumin HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens McMahon, C., Kruse, A.C. 2.6 X-RAY DIFFRACTION 0.256 0.221 False True IGHV1 None None None None None 6mee A B 0 IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 1.36 X-RAY DIFFRACTION 0.191 0.167 False True IGHV1 IGKV1 Kappa None None None None None 4gxu Q R 0 E protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/04/12 Crystal structure of antibody 1F1 bound to the 1918 influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 3.294 X-RAY DIFFRACTION 0.255 0.219 False True IGHV3 IGLV1 Lambda 6.24e-09 SPR 23236279 5mub U V 0 W peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 7l5j W L 0 B protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 12/22/20 Mouse Norovirus Protruding domain complexed with neutralizing Fab fragment from mAb A6.2 MURINE NOROVIRUS 1; MUS MUSCULUS mus musculus mus musculus murine norovirus 1 Smith, T.J., Sherman, M.B. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV4 Kappa None None None None None 3h3p H L 0 S peptide 4e10_s0_1tjlc_004_n IMMUNE SYSTEM 04/16/09 Crystal structure of HIV epitope-scaffold 4E10 Fv complex HOMO SAPIENS; ARTIFICIAL GENE homo sapiens homo sapiens artificial gene Holmes, M.A. 2.7 X-RAY DIFFRACTION 0.287 0.229 False True IGHV1 IGKV3 Kappa 1.40e-08 -10.71 SPR 25 19906921 7f0t E NA 0 A | B | D protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/07/21 Cryo-EM structure of dopamine receptor 1 and mini-Gs complex with dopamine bound HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Xiao, T., Zheng, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4nm8 J N 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 11/14/13 Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Lee, P.S., Wilson, I.A. 4.0041 X-RAY DIFFRACTION 0.292 0.240 False True IGHV1 IGKV4 Kappa 2.5e-09 -11.735309499921595 BLI TBD 1z3g H L 0 A protein ookinete surface protein pvs25 IMMUNE SYSTEM/CELL ADHESION 03/12/05 Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8 MUS MUSCULUS; PLASMODIUM VIVAX SAI-1 mus musculus mus musculus plasmodium vivax sai-1 Saxena, A.K., Singh, K., Su, H.P., Klein, M.M., Stowers, A.W., Saul, A.J., Long, C.A., Garboczi, D.N. 3.3 X-RAY DIFFRACTION 0.327 0.272 False True IGHV1 IGKV4 Kappa None None None None None 1nqb A a 0 IMMUNOGLOBULIN 04/04/97 TRIVALENT ANTIBODY FRAGMENT MUS MUSCULUS mus musculus Williams, R.L., Pei, X.Y. 2.0 X-RAY DIFFRACTION 0.230 0.187 True True unknown unknown unknown None None None None None 3ghb H L 0 P peptide envelope glycoprotein IMMUNE SYSTEM 03/03/09 Crystal structure of anti-HIV-1 Fab 447-52D in complex with V3 peptide W2RW020 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.P., Burke, V.J. 2.25 X-RAY DIFFRACTION 0.232 0.196 False False IGHV3 IGLV1 Lambda None None None None None 2r0w H L 0 Q peptide amyloid beta peptide fragment IMMUNE SYSTEM 08/21/07 PFA2 FAB complexed with Abeta1-8 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Gardberg, A.S., Dealwis, C. 2.503 X-RAY DIFFRACTION 0.277 0.208 False False IGHV8 IGKV1 Kappa None None None None None 1kxv D NA 0 B protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 1.6 X-RAY DIFFRACTION 0.229 0.205 False True IGHV1 2.50e-08 -10.37 SPR 11960990 6sxi A B 0 NA NA NA NA IMMUNE SYSTEM 09/26/19 Antibody-anti-idiotype complex: AP33 Fab (hepatitis C virus E2 antibody) - B2.1A scFv (anti-idiotype) MUS MUSCULUS mus musculus mus musculus Taylor, G.L., Potter, J.A., Fadda, V., Patel, A.H., Owsianka, A.M., Cowtan, V.M. 1.85 X-RAY DIFFRACTION 0.203 0.156 False False IGHV1 IGKV6 Kappa None None None None None 7rks H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C118 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Jette, C.A., Bjorkman, P.J., Barnes, C.O. 2.7 X-RAY DIFFRACTION 0.247 0.195 False True IGHV3 IGLV4 Lambda None None None None None 1a4j H L 0 IMMUNOGLOBULIN 01/30/98 DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR MUS MUSCULUS mus musculus mus musculus Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C. 2.1 X-RAY DIFFRACTION 0.292 0.229 False True IGHV9 IGKV1 Kappa None None None None None 3o6m H L 0 C peptide protein tat 9-mer peptide IMMUNE SYSTEM 07/29/10 Anti-Tat HIV 11H6H1 Fab' complexed with a 9-mer Tat peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Serriere, J., Gouet, P., Guillon, C. 2.4 X-RAY DIFFRACTION 0.290 0.211 False False IGHV5 IGKV1 Kappa 3.30e-08 -9.89 Other 16 21035463 6b20 F NA 0 A protein NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/19/17 Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator BOS TAURUS; LAMA GLAMA lama glama bos taurus Gulati, S., Kiser, P.D., Palczewski, K. 2.34 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 1dqj B A 0 C protein lysozyme immune system/hydrolase 01/04/00 CRYSTAL STRUCTURE OF THE ANTI-LYSOZYME ANTIBODY HYHEL-63 COMPLEXED WITH HEN EGG WHITE LYSOZYME MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Li, H., Mariuzza, R.A. 2.0 X-RAY DIFFRACTION 0.250 0.217 False True IGHV3 IGKV5 Kappa 2.86e-09 -11.45 SPR 25 10828942 7vuy S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/04/21 Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12. state1 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yu, L., Fang, Y. 2.84 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4gxu O P 0 C protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 09/04/12 Crystal structure of antibody 1F1 bound to the 1918 influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 3.294 X-RAY DIFFRACTION 0.255 0.219 False True IGHV3 IGLV1 Lambda 6.24e-09 SPR 23236279 7t6u E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/14/21 Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2 HOMO SAPIENS; RATTUS; BOS TAURUS; SYNTHETIC CONSTRUCT rattus homo sapiens | rattus Zhuang, Y.W. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7na9 D NA 0 A protein NA botulinum neurotoxin type b TOXIN 06/20/21 Crystal structure of BoNT/B-LC-JSG-C1 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 1.76 X-RAY DIFFRACTION 0.205 0.167 False True IGHV1 NA NA None None None None None 2dqt H L 0 H Hapten CPD [1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL ESTER IMMUNE SYSTEM 05/30/06 High resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog MUS MUSCULUS mus musculus mus musculus mus musculus Kristensen, O., Vassylyev, D.G., Tanaka, F., Ito, N., Morikawa, K., Fujii, I. 1.8 X-RAY DIFFRACTION 0.246 0.187 False False IGHV5 IGKV1 Kappa None None None None None 7lfb H L 0 X protein NA apolipoprotein l1 IMMUNE SYSTEM 01/16/21 Fab 7D6 bound to ApoL1 NTD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Kirchhofer, D. 1.913 X-RAY DIFFRACTION 0.197 0.168 False True IGHV9 IGKV12 Kappa None None None None None 4g6f B D 0 F peptide gp41 mper peptide IMMUNE SYSTEM 07/19/12 Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Huang, J., Connors, M., Kwong, P.D. 2.1 X-RAY DIFFRACTION 0.218 0.180 False True IGHV3 IGLV3 Lambda 1.7e-08 -10.599564136380756 Unknown TBD 4ut6 H L 0 A protein envelope glycoprotein e VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 B7 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 3.2 X-RAY DIFFRACTION 0.2500 0.2120 False True IGHV3 IGLV2 Lambda None None None None None 4fqr q r 0 Q protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 6o3l H L 0 D peptide mper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41). HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 1.98 X-RAY DIFFRACTION 0.211 0.170 False True IGHV1 IGKV3 Kappa None None None None None 5yd5 A a 0 B peptide peptide epitope (mutation n3a) IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide (mutation N3A) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.96 X-RAY DIFFRACTION 0.258 0.203 True True unknown unknown unknown None None None None None 1yee H L 0 H Hapten PNB 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE CATALYTIC ANTIBODY 04/15/97 STRUCTURE OF A CATALYTIC ANTIBODY, IGG2A FAB FRAGMENT (D2.5) MUS MUSCULUS mus musculus mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 2.2 X-RAY DIFFRACTION 0.260 0.204 False False IGHV1 IGKV1 Kappa None None None None None 3lrh NA I 0 J peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 6b14 H L 0 R nucleic-acid rna (86-mer) RNA/IMMUNE SYSTEM 09/16/17 Spinach RNA aptamer - Fab BL3-6 S to N mutant complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct DasGupta, S., Shelke, S.A., Piccirilli, J.A. 1.64 X-RAY DIFFRACTION 0.227 0.212 False True IGHV3 IGKV1 Kappa 5e-09 -11.324631107601816 Unknown TBD 4f57 H L 0 IMMUNE SYSTEM 05/12/12 Fab structure of a neutralizing antibody L1 from an early subtype A HIV-1 infected patient HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 1.7 X-RAY DIFFRACTION 0.209 0.186 False False IGHV3 IGLV2 Lambda None None None None None 2vdq H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.59 X-RAY DIFFRACTION 0.190 0.141 False False IGHV14 IGKV14 Kappa None None None None None 1dbj H L 0 H Hapten AE2 AETIOCHOLANOLONE IMMUNOGLOBULIN 08/24/93 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY MUS MUSCULUS mus musculus mus musculus mus musculus Arevalo, J.H., Wilson, I.A. 2.7 X-RAY DIFFRACTION unknown 0.214 False True IGHV9 IGKV1 Kappa None None None None None 7t0r C B 0 D protein NA t-cell surface glycoprotein cd4 ANTIVIRAL PROTEIN 11/30/21 Crystal structure of the anti-CD4 adnectin 6940_B01 as a complex with the extracellular domains of CD4 and ibalizumab fAb MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Williams, S.P., Concha, N.O., Wensel, D.L., Hong, X. 3.65 X-RAY DIFFRACTION 0.292 0.226 False True IGHV1 IGKV4 Kappa None None None None None 6fy3 X Y 0 Z peptide cap45 v2 peptide IMMUNE SYSTEM 03/10/18 Crystal structure of a V2-directed, RV144 vaccine-like antibody from HIV-1 infection, CAP228-3D, bound to a heterologous V2 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Moore, P.L., Morris, L. 2.6 X-RAY DIFFRACTION 0.250 0.220 False True IGHV5 IGLV6 Lambda None None None None None 5o1r I M 0 B protein gna2132 IMMUNE SYSTEM 05/19/17 human Fab 5H2 bound to NHBA-C3 from Neisseria meningitidis serogroup B NEISSERIA MENINGITIDIS; HOMO SAPIENS homo sapiens homo sapiens neisseria meningitidis Enrico, M., Maritan, M. 2.86 X-RAY DIFFRACTION 0.222 0.178 False True IGHV4 IGKV1 Kappa None None None None None 4tnw W f 0 P protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False unknown unknown unknown None None None None None 5te6 H L 0 G protein clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 09/20/16 Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in complex with HIV-1 Clade AE strain 93TH057 core gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.278 0.227 False True unknown unknown unknown 2.59e-09 -11.714355044389787 SPR TBD 4lbe A B 0 C protein ph-gated potassium channel kcsa TRANSPORT PROTEIN, membrane protein 06/20/13 Structure of KcsA with R122A mutation STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Nimigean, C.M., Posson, D.J., McCoy, J.M. 2.751 X-RAY DIFFRACTION 0.202 0.167 False True IGHV1 IGKV5 Kappa None None None None None 5fyl D E 0 B protein bg505 gp120 env ectodomain 03/08/16 Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Stewart-Jones, G.B.E., Zhou, T., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.3072 0.2503 False True unknown unknown unknown None None None None None 6itq D NA 0 D Hapten HCY (11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE IMMUNE SYSTEM 11/24/18 Crystal structure of cortisol complexed with its nanobody at pH 10.5 CAMELUS BACTRIANUS camelus bactrianus camelus bactrianus Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. 1.526 X-RAY DIFFRACTION 0.256 0.223 False True unknown unknown unknown None None None None None 6m0z H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 02/24/20 X-ray structure of Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in L-norepinephrine bound form DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Shabareesh, P., Mallela, A.K., Joseph, D., Penmatsa, A. 2.88 X-RAY DIFFRACTION 0.243 0.213 False True IGHV5 IGKV4 Kappa None None None None None 6pv7 F G 0 D | E protein | protein NA | NA fusion protein of neuronal acetylcholine receptor subunitalpha-3 and soluble cytochrome b562 | fusion protein of neuronal acetylcholine receptor subunitbeta-4 and soluble cytochrome b562 MEMBRANE PROTEIN 07/19/19 Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine HOMO SAPIENS; ESCHERICHIA COLI O11; MUS MUSCULUS mus musculus mus musculus homo sapiens, escherichia coli o11 | homo sapiens, escherichia coli o11 Gharpure, A., Teng, J., Zhuang, Y., Noviello, C.M., Walsh, R.M., Cabuco, R., Howard, R.J., Zaveri, N.T., Lindahl, E., Hibbs, R.E. 3.34 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 3qyc A NA 0 IMMUNE SYSTEM 03/03/11 Structure of a dimeric anti-HER2 single domain antibody homo sapiens Baral, T.N., Chao, S., Li, S., Tanha, J., Arbabai, M., Wang, S., Zhang, J. 1.6 X-RAY DIFFRACTION 0.229 0.209 False True IGHV3 None None None None None 6ym0 H L 0 E protein rbd VIRAL PROTEIN 04/07/20 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab (crystal form 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huo, J., Zhao, Y., Ren, J., Zhou, D., Ginn, H.M., Fry, E.E., Owens, R., Stuart, D.I. 4.36 X-RAY DIFFRACTION 0.319 0.323 False True IGHV5 IGKV4 Kappa None None None None None 6tcp H L 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.5 X-RAY DIFFRACTION 0.239 0.212 False True IGHV3 IGKV1 Kappa None None None None None 1eeu NA B 0 IMMUNE SYSTEM 02/03/00 M4L/Y(27D)D/Q89D/T94H mutant of LEN HOMO SAPIENS homo sapiens Pokkuluri, P.R., Cai, X., Gu, M., Stevens, F.J., Schiffer, M. 1.6 X-RAY DIFFRACTION 0.222 0.194 False True IGKV4 Kappa None None None None None 6os0 D NA 0 A protein type-1 angiotensin ii receptor,soluble cytochrome b562 brilfusion protein MEMBRANE PROTEIN 05/01/19 Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens, escherichia coli Wingler, L.M., Staus, D.P., Skiba, M.A., McMahon, C., Kleinhenz, A.L.W., Lefkowitz, R.J., Kruse, A.C. 2.9 X-RAY DIFFRACTION 0.318 0.259 False True IGHV1 None None None None None 1rz8 B A 0 IMMUNE SYSTEM 12/24/03 CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.262 0.212 False True IGHV1 IGKV3 Kappa None None None None None 7whk D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7m7w E F 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/29/21 Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 2.65 X-RAY DIFFRACTION 0.271 0.221 False True IGHV5 IGLV2 Lambda None None None None None 6zwk A NA 0 G peptide NA histone h2ax IMMUNE SYSTEM 07/28/20 Crystal structure of the phosphorylated C-terminal tail of histone H2AX in complex with a specific nanobody (C6 gammaXbody) VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens McEwen, A.G., Moeglin, E., Desplancq, D., Weiss, E., Poterszman, A. 1.55 X-RAY DIFFRACTION 0.184 0.149 False True IGHV1 NA NA None None None None None 6o9h A B 0 C protein ecd IMMUNE SYSTEM 03/13/19 Mouse ECD with Fab1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Min, X., Wang, Z. 2.1 X-RAY DIFFRACTION 0.248 0.203 False True IGHV5 IGKV8 Kappa None None None None None 7dfa H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | varpp-4 SIGNALING PROTEIN 11/06/20 Crystal of Arrestin2-V2Rpp-4-Fab30 complex BOS TAURUS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | synthetic construct Sun, J.P., Yu, X., Xiao, P., He, Q.T., Lin, J.Y., Zhu, Z.L. 2.54 X-RAY DIFFRACTION 0.280 0.234 False True IGHV3 IGKV1 Kappa None None None None None 7mzf H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab PDI 37 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Chan, L.J., Dietrich, M.H., Tan, L.L., Tham, W.H. 2.493 X-RAY DIFFRACTION 0.227 0.185 False True IGHV3 IGKV1 Kappa None None None None None 5m2w A NA 0 IMMUNE SYSTEM 10/13/16 Structure of nanobody nb18 raised against TssK from E. coli T6SS LAMA GLAMA lama glama Cambillau, C., Nguyen, V.S., Spinelli, S., Desmyter, A. 1.5 X-RAY DIFFRACTION 0.214 0.203 False True IGHV1 None None None None None 6qtl H NA 0 H Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 6wmw M N 0 B protein NA gdnf family receptor alpha-like IMMUNE SYSTEM 04/21/20 GFRAL receptor bound with two antibody Fabs (3P10, 25M22) HOMO SAPIENS homo sapiens homo sapiens homo sapiens White, A., Lakshminarasimhan, D., Olland, A., Suto, R.K. 2.91 X-RAY DIFFRACTION 0.290 0.222 False True IGHV1 IGKV1 Kappa None None None None None 7e8f D E 0 R protein NA spike protein s1 VIRAL PROTEIN 03/01/21 SARS-CoV-2 NTD in complex with N9 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4n1e NA F 0 K protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 7whz C E 0 A protein NA spike protein s1 VIRAL PROTEIN 01/01/22 SARS-CoV-2 spike protein in complex with three human neutralizing antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Li, S., Sun, H., Zheng, Z., Wang, S. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7km5 D NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/20 Crystal structure of SARS-CoV-2 RBD complexed with Nanosota-1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Ye, G., Shi, K., Aihara, H., Li, F. 3.19 X-RAY DIFFRACTION 0.294 0.247 False True IGHV1 NA NA None None None None None 5vzx E I 0 IMMUNE SYSTEM 05/29/17 Crystal structure of crenezumab Fab HOMO SAPIENS homo sapiens homo sapiens Ultsch, M., Wang, W. 2.501 X-RAY DIFFRACTION 0.230 0.185 False True IGHV3 IGKV1 Kappa None None None None None 7jkm K NA 0 NA NA NA NA IMMUNE SYSTEM 07/28/20 REGN1 Human Fab in complex with anti-Kappa VHH domain HOMO SAPIENS; LAMA GLAMA lama glama Dennis, T.N., de la Cruz, M., Williams, J.C. 1.78 X-RAY DIFFRACTION 0.210 0.182 False True IGHV1 NA NA None None None None None 1kn2 H L 0 L Hapten PNE PARA-NITROPHENYL PHOSPHONOBUTANOYL L-ALANINE IMMUNE SYSTEM 12/18/01 CATALYTIC ANTIBODY D2.3 COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Knossow, M. 1.9 X-RAY DIFFRACTION 0.238 0.213 False False IGHV1 IGKV1 Kappa None None None None None 5dhx B b 0 C protein protein rev IMMUNE SYSTEM 08/31/15 HIV-1 Rev NTD dimers with variable crossing angles ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus human immunodeficiency virus 1 DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C. 2.9 X-RAY DIFFRACTION 0.273 0.246 True True unknown unknown unknown None None None None None 7e5r W R 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5bjz C L 0 A protein maltose-binding periplasmic protein SUGAR BINDING PROTEIN 09/12/17 Crystal structure of maltose binding protein in complex with an allosteric synthetic antibody ESCHERICHIA COLI O157:H7; HOMO SAPIENS homo sapiens homo sapiens escherichia coli o157 Mukherjee, S., Kossiakoff, A.A. 1.95 X-RAY DIFFRACTION 0.229 0.194 False True IGHV3 IGKV1 Kappa None None None None None 3umt A a 0 IMMUNE SYSTEM 11/14/11 scFv12, Anti-BclA antibody single chain variable fragment MUS MUSCULUS mus musculus Pokkuluri, P.R. 1.798 X-RAY DIFFRACTION 0.223 0.175 True True unknown unknown unknown None None None None None 6uyg A B 0 E protein envelope glycoprotein e2 IMMUNE SYSTEM 11/13/19 Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3B and non neutralizing antibody E1 RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1; HOMO SAPIENS; STREPTOCOCCUS SP. homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Zhu, J. 3.375 X-RAY DIFFRACTION 0.306 0.254 False True IGHV1 IGKV2 Kappa None None None None None 2fl5 F E 0 F Hapten RBF RIBOFLAVIN IMMUNE SYSTEM 01/05/06 Cofactor-containing antibodies: Crystal structure of the original yellow antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.290 0.240 False False IGHV3 IGLV3 Lambda 1.8000000000000002e-09 -11.929942798416155 Unknown TBD 7neq F E 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 02/04/21 Structure of tariquidar-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kowal, J., Locher, K. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 6ncp C D 0 E peptide hiv-1 fusion peptide (residues 512-520) IMMUNE SYSTEM 12/11/18 Crystal structure of HIV-1 broadly neutralizing antibody ACS202 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Yuan, M., Wilson, I.A. 2.76 X-RAY DIFFRACTION 0.256 0.222 False True IGHV3 IGKV1 Kappa None None None None None 4xmp H L 0 G protein envelope glycoprotein gp160,envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 01/15/15 Crystal structure of broadly and potently neutralizing antibody VRC08 in complex with HIV-1 clade A strain Q842.d12 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 1.7831 X-RAY DIFFRACTION 0.201 0.165 False True unknown unknown unknown None None None None None 3cm9 B M 9 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5mp2 D NA 0 B protein type ii secretion system protein d TRANSPORT PROTEIN 12/15/16 XcpQN012 in complex with VHH04 PSEUDOMONAS AERUGINOSA; LAMA GLAMA lama glama pseudomonas aeruginosa Trinh, T.T.N., Roussel, A., Douzi, B., Voulhoux, R. 2.9 X-RAY DIFFRACTION 0.256 0.213 False True IGHV1 None None None None None 6ztr H L 0 I protein NA cadherin-3 IMMUNE SYSTEM 07/20/20 Crystal Structure of the anti-human P-Cadherin Fab CQY684 in complex with human P-Cadherin(108-324) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 2.1 X-RAY DIFFRACTION 0.221 0.192 False True IGHV6 IGKV1 Kappa None None None None None 6al4 B A 0 IMMUNE SYSTEM 08/07/17 CRYSTAL STRUCTURE OF ANTI-CD19 ANTIBODY B43 FAB HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.45 X-RAY DIFFRACTION 0.236 0.206 False True IGHV1 IGKV1 Kappa None None None None None 6qf6 C c 0 APOPTOSIS 01/09/19 Structure of an E.coli expressed anti-Mcl1 scFv HOMO SAPIENS homo sapiens Luptak, J. 2.59 X-RAY DIFFRACTION 0.262 0.181 True True unknown unknown unknown None None None None None 7u8j H L 0 B | A protein | protein NA | NA hemagglutinin ha2 subunit | hemagglutinin ha1 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH4/3 in complex with broad protective antibody 31.a.83 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Zhu, X., Wilson, I.A. 4.9 X-RAY DIFFRACTION 0.340 0.324 False True IGHV3 IGKV3 Kappa None None None None None 6mug H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/23/18 Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-386150 in Complex with Human Antibodies 3H109L and 35O22 at 3.8 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.954 X-RAY DIFFRACTION 0.290 0.230 False True IGHV4 unknown unknown None None None None None 4unt NA B 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 6nb3 D E 0 A protein spike glycoprotein VIRUS 12/06/18 MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1) MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.5 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 3cm9 A L 7 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7lm8 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/21 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with two cross-neutralizing antibodies CV38-142 and COVA1-16 Fabs isolated from COVID-19 patients SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 1.936 X-RAY DIFFRACTION 0.201 0.169 False True IGHV1 IGKV1 Kappa None None None None None 6o2b C D 0 G | E | J peptide | protein | protein NA | NA | NA circumsporozoite protein | anti-kappa vhh domain | anti-kappa vhh domain IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein DND and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | lama glama | lama glama Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.210 0.177 False True IGHV3 IGKV3 Kappa None None None None None 7z1c E NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-B5 and H11-F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 1.9 X-RAY DIFFRACTION 0.199 0.175 False True IGHV1 NA NA None None None None None 2kh2 B b 49 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6nip A B 0 E protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/31/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ1 in complex with ZIKV E glycoprotein HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 4.16 X-RAY DIFFRACTION 0.237 0.188 False True IGHV4 IGLV1 Lambda None None None None None 7pry A B 0 I protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with COVOX-45 and beta-6 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.1 X-RAY DIFFRACTION 0.291 0.245 False True IGHV3 IGKV1 Kappa None None None None None 7n0i K NA 0 E | F protein | protein NA | NA nucleoprotein | nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/25/21 Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Ye, Q., Corbett, K.D. 2.2 X-RAY DIFFRACTION 0.271 0.239 False True IGHV1 NA NA None None None None None 4lex H L 0 IMMUNE SYSTEM 06/26/13 Unliganded crystal structure of mAb7 MUS MUSCULUS mus musculus mus musculus Murray, J.M., Mukund, S. 2.02 X-RAY DIFFRACTION 0.218 0.185 False True IGHV4 IGKV1 Kappa None None None None None 5uk4 d NA 0 D protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 6n1v 3 4 0 F protein vrc03 heavy chain VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False True IGHV4 IGLV1 Lambda None None None None None 4w2o C NA 0 D protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody B Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS (STRAIN MUSOKE-80) lama glama lake victoria marburgvirus (strain musoke-80) Taylor, A.B., Garza, J.A. 3.2 X-RAY DIFFRACTION 0.285 0.227 False True IGHV1 None None None None None 6e5p O P 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7lxy F C 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2X333 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1b4j H L 0 ANTIBODY ENGINEERING 12/22/98 COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY HOMO SAPIENS homo sapiens homo sapiens Fan, Z., Shan, L., Goldsteen, B.Z., Guddat, L.W., Thakur, A., Landolfi, N.F., Co, M.S., Vasques, M., Queen, C., Ramsland, P.A., Edmundson, A.B. 2.9 X-RAY DIFFRACTION 0.330 0.193 False False IGHV1 IGKV6 Kappa None None None None None 7kqk H L 0 P peptide NA ptau peptide IMMUNE SYSTEM 11/16/20 anti-pTau C21-ABS Fab in complex with pTau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Mosyak, L., Brinth, A. 2.6 X-RAY DIFFRACTION 0.231 0.211 False True IGHV3 IGLV3 Lambda None None None None None 6ot1 F I 0 E protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 6jb5 A NA 0 B protein lysozyme c IMMUNE SYSTEM/HYDROLASE 01/25/19 Crystal structure of nanobody D3-L11 mutant Y102A in complex with hen egg-white lysozyme (form II) CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Caaveiro, J.M.M., Tamura, H., Akiba, H., Tsumoto, K. 1.55 X-RAY DIFFRACTION 0.169 0.132 False True IGHV1 None None None None None 6pdu H L 0 C peptide NA hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 06/19/19 Vaccine-elicited NHP FP-targeting antibody 13N024-a.01 in complex with HIV fusion peptide (residue 512-519) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 1.953 X-RAY DIFFRACTION 0.211 0.173 False True IGHV3 IGKV2 Kappa None None None None None 4tnw Y g 0 T protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False unknown unknown unknown None None None None None 5a1z G H 0 A protein envelope protein 05/06/15 Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Jr, J.E., Lok, S.M. 6.9 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 7wef C L 0 E protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv289 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5xhg D C 0 IMMUNE SYSTEM 04/20/17 Crystal structure of Trastuzumab Fab fragment bearing Ne-(o-azidobenzyloxycarbonyl)-L-lysine ESCHERICHIA COLI STR. K-12 SUBSTR. W3110 escherichia coli str. k-12 substr. w3110 escherichia coli str. k-12 substr. w3110 Kuratani, M., Yanagisawa, T., Sakamoto, K., Yokoyama, S. 1.76 X-RAY DIFFRACTION 0.199 0.173 False True IGHV3 IGKV1 Kappa None None None None None 4z5r B A 0 N protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 4olw H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07-G54H in complex with clade A/E 93TH057 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.709 X-RAY DIFFRACTION 0.257 0.196 False True unknown IGKV3 Kappa None None None None None 7lpn D NA 0 C protein NA envelope glycoprotein gp160 VIRAL PROTEIN 02/12/21 Cryo-EM structure of llama J3 VHH antibody in complex with HIV-1 Env BG505 DS-SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.61 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 4r4n Q R 0 P | b protein | peptide NA | NA m48u1 peptide | unknown VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | synthetic construct Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 3cm9 C N 7 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6qv2 F NA 0 D protein uncharacterized abc transporter atp-binding proteintm_0288 MEMBRANE PROTEIN 03/01/19 Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); VICUGNA PACOS vicugna pacos thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 4.23 X-RAY DIFFRACTION 0.330 0.306 False True IGHV1 None None None None None 2bse D NA 0 B protein receptor binding protein RECEPTOR 05/20/05 Structure of Lactococcal Bacteriophage p2 Receptor Binding Protein in complex with a llama VHH domain LACTOCOCCUS LACTIS PHAGE P2; LAMA GLAMA lama glama lactococcus lactis phage p2 Spinelli1, S., Desmyter, A., Verrips, C.T., deHaard, H.J.W., Moineau, S., Cambillau, C. 2.7 X-RAY DIFFRACTION 0.294 0.251 False True IGHV1 None None None None None 7ceb C D 0 B protein NA integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 06/22/20 Crystal structure of alpha6beta1 integrin headpiece HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 2.89 X-RAY DIFFRACTION 0.249 0.207 False True IGHV5 IGKV4 Kappa None None None None None 7kgu H L 0 NA NA NA NA IMMUNE SYSTEM 10/18/20 Structure of 2Q1-Fab, an antibody selective for IDH2R140Q-HLA-B*07:02 HOMO SAPIENS homo sapiens homo sapiens Miller, M.S., Aytenfisu, T.Y., Wright, K.M., Gabelli, S.B. 2.4 X-RAY DIFFRACTION 0.269 0.208 False True IGHV3 IGKV1 Kappa None None None None None 7d0b H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-3C12_1B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, R.K., Ju, B., Yu, J.F., Zhang, Y.Y., Liu, N., Wang, H.W., Wang, X.Q., Zhang, L.Q., Zhou, Q. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV4 Kappa None None None None None 6o2b A B 0 F peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein DND and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.210 0.177 False True IGHV3 IGKV3 Kappa None None None None None 6s3d E F 0 O protein s0_2.126 ANTIVIRAL PROTEIN 06/25/19 Structure of D25 Fab in complex with scaffold S0_2.126 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Cramer, J.T., Krey, T. 3.0 X-RAY DIFFRACTION 0.292 0.269 False True IGHV1 IGKV1 Kappa None None None None None 4jan H L 0 G protein envelope glycoprotein gp120 of hiv-1 clade c viral protein/immune system 02/18/13 crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D. 3.15 X-RAY DIFFRACTION 0.256 0.196 False True IGHV4 IGLV3 Lambda 2e-08 -10.503274322962254 SPR TBD 4plk I G 0 F protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 05/18/14 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12 HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Li, S.W., Sivaraman, J. 4.0 X-RAY DIFFRACTION 0.296 0.264 False False IGHV1 IGKV12 Kappa None None None None None 7pry F G 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with COVOX-45 and beta-6 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.1 X-RAY DIFFRACTION 0.291 0.245 False True IGHV3 IGKV1 Kappa None None None None None 6vl8 H L 0 C Hapten PEU 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL IMMUNE SYSTEM 01/23/20 Anti-PEG antibody 6-3 Fab fragment in complex with PEG MUS MUSCULUS mus musculus mus musculus mus musculus Nicely, N.I., Huckaby, J.T., Lai, S.K., Jacobs, T.M. 2.42 X-RAY DIFFRACTION 0.240 0.185 False True IGHV9 IGKV8 Kappa None None None None None 7u0b H L 0 NA NA NA NA ANTIVIRAL PROTEIN,IMMUNE SYSTEM 02/17/22 Crystal structure of broadly neutralizing antibody HEPC3.1 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 2.79 X-RAY DIFFRACTION 0.244 0.212 False True IGHV1 IGKV1 Kappa None None None None None 6zg3 J NA 0 F | D protein | protein NA | NA energy-coupling factor transporter atp-binding proteinecfa1 | putative cobalt abc transporter, permease protein TRANSPORT PROTEIN 06/18/20 the structure of ECF PanT transporter in a complex with a nanobody LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS ATCC 11842 = JCM 1002; LAMA GLAMA lama glama lactobacillus delbrueckii subsp. bulgaricusatcc 11842 = jcm 1002 | lactobacillus delbrueckii subsp. bulgaricusatcc 11842 = jcm 1002 Setyawati, I., Guskov, A., Slotboom, D.J. 2.8 X-RAY DIFFRACTION 0.276 0.242 False False IGHV1 NA NA None None None None None 6xp6 J I 0 D | E | F protein | protein | peptide NA | NA | NA mhc class ii hla-dq-alpha chain | mhc class ii hla-dq-beta-1 | dq2-glia-a2 peptide PEPTIDE BINDING PROTEIN 07/08/20 3C11-DQ2-glia-a2 complex HOMO SAPIENS; TRITICUM AESTIVUM homo sapiens homo sapiens homo sapiens | homo sapiens | triticum aestivum Petersen, J., Rossjohn, J. 2.4 X-RAY DIFFRACTION 0.212 0.176 False True IGHV1 IGKV1 Kappa None None None None None 6ugt A B 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of PF06438179/GP1111 an infliximab biosimilar in a I-centered orthorhombic crystal form, Lot A HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H.D. 2.15 X-RAY DIFFRACTION 0.228 0.185 False True IGHV6 IGKV5 Kappa None None None None None 7mem G J 0 C protein NA hemagglutinin ha1 chain Viral protein/IMMUNE SYSTEM 04/06/21 CryoEM structure of monoclonal Fab 045-09 2B05 binding the lateral patch of influenza virus H1 HA INFLUENZA A VIRUS (STRAIN SWL A/CALIFORNIA/04/2009 H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain swla/california/04/2009 h1n1) Han, J., Ward, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7mxe A B 0 J | F protein | protein NA | NA envelope glycoprotein bg505 sosip.664 gp120 | hiv-1 envelope glycoprotein bg505 sosip.664 gp41 ANTIVIRAL PROTEIN/VIRAL PROTEIN 05/19/21 Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Abernathy, M.E., Bjorkman, P.J. 3.7 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5eoq H L 0 A peptide protein a27 VIRAL PROTEIN/IMMUNE SYSTEM 11/10/15 Structure of the murine Fab 1G6 bound to the vaccinia virus A27 peptide 31-40 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus vaccinia virus Matho, M.H., Zajonc, D.M. 1.95 X-RAY DIFFRACTION 0.235 0.197 False False IGHV8 IGKV1 Kappa None None None None None 6dbf B NA 0 A protein listeria virulence factor inlb IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R303 in complex with InlB-LRR LISTERIA MONOCYTOGENES; CAMELUS DROMEDARIUS camelus dromedarius listeria monocytogenes Brooks, C.L., Toride King, M., Huh, I. 1.55 X-RAY DIFFRACTION 0.163 0.138 False True IGHV1 None None None None None 5mub A B 0 X peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 1mch NA B 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-b-ala-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 7zfa Q R 0 A protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV3 IGKV1 Kappa None None None None None 6dwi J I 0 J carbohydrate HD4 4-O-[2-acetamido-2-deoxy-beta-D-glucopyranosyl]-1-O-phosphono-D-ribitol IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 7d5z D C 0 A protein NA envelope glycoprotein h VIRAL PROTEIN 09/28/20 Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8 HUMAN GAMMAHERPESVIRUS 4; HOMO SAPIENS homo sapiens homo sapiens human gammaherpesvirus 4 Zhu, Q., Shan, S., Yu, J., Wang, X., Zhang, L., Zeng, M. 4.2 X-RAY DIFFRACTION 0.277 0.246 False True IGHV3 IGKV1 Kappa None None None None None 7s8l E e 0 B | C protein | protein NA | NA gs-mini-gq chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/18/21 CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Cao, C., Fay, J.F., Gumpper, R.H., Roth, B.L. 2.45 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6nex H L 0 IMMUNE SYSTEM 12/18/18 Fab fragement of anti-cocaine antibody h2E2 MUS MUSCULUS mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.15 X-RAY DIFFRACTION 0.254 0.214 False True IGHV3 IGLV2 Lambda None None None None None 7si0 K L 0 H protein NA ige fc IMMUNE SYSTEM 10/12/21 IgE-Fc in complex with 813 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.261 0.210 False True IGHV3 IGKV1 Kappa None None None None None 1g9e A NA 8 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 4zfo H L 0 K peptide tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 04/21/15 J22.9-xi: chimeric mouse/human antibody against human BCMA (CD269) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Marino, S.F., Daumke, O., Olal, D. 1.895 X-RAY DIFFRACTION 0.209 0.176 False True IGHV4 IGKV6 Kappa 2.1e-11 -14.567099215178107 Unknown TBD 7o9s H L 0 A protein NA envelope polyprotein VIRAL PROTEIN 04/16/21 Hantaan virus Gn in complex with Fab nnHTN-Gn2 ORYCTOLAGUS CUNICULUS; HANTAAN ORTHOHANTAVIRUS oryctolagus cuniculus oryctolagus cuniculus hantaan orthohantavirus Rissanen, I., Bowden, T.A., Huiskonen, J.T., Stass, R. 2.7 X-RAY DIFFRACTION 0.267 0.211 False True IGHV1 IGKV1 Kappa None None None None None 6ui1 C NA 0 A protein bont/a TOXIN/ANTITOXIN 09/29/19 Crystal structure of BoNT/A-LCHn domain in complex with VHH ciA-D12, ciA-B5, and ciA-H7 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.20001 X-RAY DIFFRACTION 0.229 0.181 False True IGHV1 None None None None None 6utk D E 0 T protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/19 Crystal structure of 438-B11 Fab in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 at 3.80 Angstrom HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 3.8 X-RAY DIFFRACTION 0.317 0.299 False True unknown unknown unknown None None None None None 6wg2 H L 0 P peptide NA npna4 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab239 in complex with NPNA4 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 2.534 X-RAY DIFFRACTION 0.246 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7rm1 A B 0 P peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide EDGAGNQPGANGAGNQPGANGAGNQPG MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 3.19 X-RAY DIFFRACTION 0.210 0.180 False True IGHV9 IGKV8 Kappa None None None None None 7nki F NA 0 A protein NA polymerase acidic protein VIRAL PROTEIN 02/18/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (a/brevigmission/1/1918(h1n1)) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.67 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2bx5 NA B 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 2a6j B A 0 IMMUNE SYSTEM 07/02/05 Crystal structure analysis of the anti-arsonate germline antibody 36-65 MUS MUSCULUS mus musculus mus musculus Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M. 2.7 X-RAY DIFFRACTION 0.265 0.225 False False IGHV1 IGKV10 Kappa None None None None None 1shm B NA 0 IMMUNE SYSTEM 02/26/04 Convergent solutions to VHH domain stabilization from natural and in vitro evolution LAMA GLAMA lama glama Bond, C.J., Wiesmann, C., Marsters, J.C., Sidhu, S.S. 1.9 X-RAY DIFFRACTION 0.236 0.185 False True IGHV1 None None None None None 2qtj B M 2 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 1dqm H L 0 IMMUNE SYSTEM 01/04/00 CRYSTAL STRUCTURE OF ANTI-LYSOZYME ANTIBODY MUS MUSCULUS mus musculus mus musculus Li, H., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.268 0.225 False True IGHV3 IGKV5 Kappa None None None None None 2qtj D N 4 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6j15 A B 0 C protein programmed cell death protein 1 IMMUNE SYSTEM 12/27/18 Complex structure of GY-5 Fab and PD-1 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Chen, D., Tan, S., Zhang, H., Wang, H., Chai, Y., Qi, J., Yan, J., Gao, G.F. 2.6 X-RAY DIFFRACTION 0.277 0.212 False False IGHV1 IGKV1 Kappa None None None None None 4dk3 A NA 0 C protein rna-editing complex protein mp81 RNA BINDING PROTEIN/IMMUNE SYSTEM 02/03/12 Structure of Editosome protein LAMA GLAMA; TRYPANOSOMA BRUCEI lama trypanosoma brucei Park, Y.-J., Hol, W. 2.76 X-RAY DIFFRACTION 0.267 0.224 False True IGHV1 None None None None None 7rxi H L 0 A protein NA circumsporozoite protein IMMUNE SYSTEM 08/23/21 Fab234 in complex with the C-terminal alpha-TSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 2.15 X-RAY DIFFRACTION 0.265 0.219 False True IGHV3 IGLV3 Lambda None None None None None 6otc H L 0 A protein polymerase cofactor vp35 VIRAL PROTEIN/IMMUNE SYSTEM 05/02/19 Synthetic Fab bound to Marburg virus VP35 interferon inhibitory domain LAKE VICTORIA MARBURGVIRUS (STRAIN POPP-67); SYNTHETIC CONSTRUCT synthetic construct synthetic construct lake victoria marburgvirus (strain popp-67) Amatya, P., Chen, G., Borek, D., Sidhu, S.S., Leung, D.W. 1.7 X-RAY DIFFRACTION 0.233 0.196 False True IGHV3 IGKV1 Kappa None None None None None 6z2m F NA 0 E protein spike glycoprotein VIRAL PROTEIN 06/03/20 H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Naismith, J.H., Ren, J., Zhou, D., Zhao, Y., Stuart, D.I. 2.71 X-RAY DIFFRACTION 0.241 0.198 False True IGHV1 None None None None None 7qu1 A B 0 C protein NA pre-glycoprotein polyprotein gp complex IMMUNE SYSTEM 01/17/22 Machupo virus GP1 glycoprotein in complex with Fab fragment of antibody MAC1 MUS MUSCULUS; MACHUPO MAMMARENAVIRUS mus musculus mus musculus machupo mammarenavirus Ng, W.M., Sahin, M., Krumm, S.A., Seow, J., Zeltina, A., Harlos, K., Paesen, G., Pinschewer, D.D., Doores, K.J., Bowden, T.A. 1.91 X-RAY DIFFRACTION 0.229 0.194 False True IGHV1 IGKV10 Kappa None None None None None 6ldx H L 0 B peptide NA gly-m3l-gly-gly-thr-tyr-pro IMMUNE SYSTEM 11/23/19 Structure antibody E6 in complex with methylated peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Tsumoto, K. 1.8 X-RAY DIFFRACTION 0.217 0.169 False True IGHV1 IGKV1 Kappa None None None None None 2kqm NA A 9 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7qji B NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.1 X-RAY DIFFRACTION 0.316 0.267 False True IGHV1 NA NA None None None None None 3ab0 E F 0 D protein bcla protein IMMUNE SYSTEM 11/28/09 Crystal structure of complex of the Bacillus anthracis major spore surface protein BclA with ScFv antibody fragment BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus mus musculus bacillus anthracis Streltsov, V.A. 3.09 X-RAY DIFFRACTION 0.265 0.197 False True IGHV5 IGKV4 Kappa None None None None None 7jvc C D 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2A4 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV6 Lambda None None None None None 5a7x P O 0 E protein hiv-1 yu2 gp120 VIRAL PROTEIN 07/10/15 negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 17.0 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 1ar2 NA A 0 IMMUNOGLOBULIN 08/08/97 DISULFIDE-FREE IMMUNOGLOBULIN FRAGMENT HOMO SAPIENS homo sapiens Uson, I., Bes, M.T., Sheldrick, G.M., Schneider, T.R., Hartsch, T., Fritz, H.-J. 2.8 X-RAY DIFFRACTION unknown unknown False True unknown unknown unknown None None None None None 6zbv B NA 0 A protein NA sodium- and chloride-dependent glycine transporter 1,sodium- and chloride-dependent glycine transporter 1 MEMBRANE PROTEIN 06/09/20 Inward-open structure of human glycine transporter 1 in complex with a benzoylisoindoline inhibitor and sybody Sb_GlyT1#7 HOMO SAPIENS; UNIDENTIFIED unidentified homo sapiens Shahsavar, A., Stohler, P., Bourenkov, G., Zimmermann, I., Siegrist, M., Guba, W., Pinard, E., Sinning, S., Seeger, M.A., Schneider, T.R., Dawson, R.J.P., Nissen, P. 3.4 X-RAY DIFFRACTION 0.259 0.214 False True IGHV1 NA NA None None None None None 6xgc H L 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain ANTIVIRAL PROTEIN 06/17/20 CryoEM structure of influenza hemagglutinin A/Michigan/45/2015 in complex with cyno antibody 1C4 INFLUENZA A VIRUS (A/MICHIGAN/45/2015(H1N1)); MACACA FASCICULARIS macaca fascicularis macaca fascicularis influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Qiu, Y., Zhou, Y. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 6e62 H L 0 P protein pf48/45 IMMUNE SYSTEM 07/23/18 Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody 85RF45.1 PLASMODIUM FALCIPARUM; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus plasmodium falciparum Kundu, P., Semesi, A., Julien, J.P. 2.7 X-RAY DIFFRACTION 0.276 0.246 False True IGHV5 IGLV3 Lambda 3.2000000000000005e-09 -11.589048932503637 SPR TBD 5wko E F 0 P | M protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 07/25/17 Crystal structure of antibody 27F3 recognizing the HA from A/California/04/2009 (H1N1) influenza virus HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wilson, A., Lang, S., Zhu, X. 3.492 X-RAY DIFFRACTION 0.268 0.246 False True IGHV1 IGKV3 Kappa None None None None None 7f2o S s 0 A | B protein | protein NA | NA g subunit q (gi1-gq chimeric) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/11/21 Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein HOMO SAPIENS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Yin, Y., Jiang, Y. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ket A B 0 C protein NA factor h binding protein IMMUNE SYSTEM 10/12/20 Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein HOMO SAPIENS; NEISSERIA MENINGITIDIS homo sapiens homo sapiens neisseria meningitidis Beernink, P.T., Sands, N. 2.0 X-RAY DIFFRACTION 0.281 0.234 False True IGHV3 IGKV3 Kappa None None None None None 4olz H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07-G54W in complex with clade A/E 93TH057 HIV-1 gp120 core HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.1 X-RAY DIFFRACTION 0.254 0.203 False True unknown IGKV3 Kappa None None None None None 7bbg H L 0 A | C protein | peptide NA | NA mhc class i antigen | wilms tumor 1 (wt1) derived peptide IMMUNE SYSTEM 12/17/20 CRYSTAL STRUCTURE OF HLA-A2-WT1-RMF AND FAB 11D06 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Bujotzek, A., Georges, G., Hanisch, L.J., Klein, C., Benz, J. 2.64 X-RAY DIFFRACTION 0.230 0.168 False True IGHV1 IGKV1 Kappa None None None None None 1riu H L 0 H Hapten RBE 3-(BENZOYLOXY)-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 11/18/03 Anti-Cocaine Antibody M82G2 Complexed With Norbenzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Petsko, G., Ringe, D. 2.0 X-RAY DIFFRACTION 0.208 0.183 False False IGHV6 IGKV2 Kappa None None None None None 6o2a H I 0 K peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein NDN and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.15 X-RAY DIFFRACTION 0.221 0.193 False True IGHV3 IGKV3 Kappa None None None None None 7wph E D 0 A protein NA spike protein s1 PROTEIN BINDING 01/23/22 SARS-CoV2 RBD bound to Fab06 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lin, J.Q., El Sahili, A., Lescar, J. 2.89 X-RAY DIFFRACTION 0.269 0.229 False True IGHV4 IGLV2 Lambda None None None None None 6obz H L 0 IMMUNE SYSTEM 03/21/19 Crystal structure of FluA-20 Fab HOMO SAPIENS homo sapiens homo sapiens Wilson, I.A., Lang, S. 1.73 X-RAY DIFFRACTION 0.238 0.202 False True IGHV4 IGKV1 Kappa None None None None None 7nd8 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-384 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7k63 M m 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/18/20 Cryo-EM structure of a chromatosome containing chimeric linker histone gH1.10-ncH1.4 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 3.03 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7p60 G NA 0 B protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4 at 1:0.5 ratio MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6lxk E F 0 D protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of Z2B3 D102R Fab in complex with influenza virus neuraminidase from A/Serbia/NS-601/2014 (H1N1) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 3.608 X-RAY DIFFRACTION 0.249 0.215 False True IGHV1 IGLV2 Lambda None None None None None 5hvg B NA 0 A protein carboxypeptidase b2 hydrolase/hydrolase inhibitor 01/28/16 Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204) VICUGNA PACOS; HOMO SAPIENS vicugna pacos homo sapiens Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 3.05 X-RAY DIFFRACTION 0.212 0.179 False True IGHV1 6.3e-10 -12.551945274084549 SPR TBD 4qf1 A B 0 IMMUNE SYSTEM 05/19/14 Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59 HOMO SAPIENS homo sapiens homo sapiens Wiehe, K., Easterhoff, D., Luo, K., Nicely, N.I., Bradley, T., Jaeger, F.H., Dennison, S.M., Zhang, R., Lloyd, K.E., Stolarchuk, C., Parks, R., Sutherland, L.L., Scearce, R.M., Morris, L., Kaewkungwal, J., Nitayaphan, S., Pitisuttithum, P., Rerks-Ngarm, S., Michael, N., Kim, J., Kelsoe, G., Montefiori, D.C., Tomaras, G., Bonsignori, M., Santra, S., Kepler, T.B., Alam, S.M., Moody, M.A., Liao, H.-X., Haynes, B.F. 2.4 X-RAY DIFFRACTION 0.229 0.182 False True IGHV3 IGLV3 Lambda None None None None None 1igt D C 0 IMMUNOGLOBULIN 10/25/96 STRUCTURE OF IMMUNOGLOBULIN MUS MUSCULUS mus musculus mus musculus Harris, L.J., Larson, S.B., Hasel, K.W., McPherson, A. 2.8 X-RAY DIFFRACTION 0.297 0.209 False False IGHV5 IGKV10 Kappa None None None None None 6nnj U V 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 01/15/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to CH31 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.1 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.6 X-RAY DIFFRACTION 0.293 0.248 False True unknown unknown unknown None None None None None 6x3s J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV14 IGKV6 Kappa None None None None None 1u91 B A 0 C peptide gp41 peptide analog IMMUNE SYSTEM 08/09/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide Analog ENDKW-[Dap]-S (cyclic) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.232 0.226 False False IGHV2 IGKV1 Kappa None None None None None 2jel H L 0 P protein histidine-containing protein COMPLEX (ANTIBODY/ANTIGEN) 02/24/98 JEL42 FAB/HPR COMPLEX MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Prasad, L., Waygood, E.B., Lee, J.S., Delbaere, L.T.J. 2.5 X-RAY DIFFRACTION 0.280 0.210 False False IGHV1 IGKV1 Kappa 3.70e-09 -11.49 Other 23 9671548 4yhn A B 0 IMMUNE SYSTEM 02/27/15 Dabigatran Reversal Agent HOMO SAPIENS homo sapiens homo sapiens Schiele, F., Nar, H. 2.31 X-RAY DIFFRACTION 0.220 0.182 False True IGHV1 IGKV1 Kappa None None None None None 4rdq M L 0 C protein bestrophin-1 TRANSPORT PROTEIN 09/19/14 Calcium-activated chloride channel bestrophin-1, from chicken, in complex with Fab antibody fragments, chloride and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Dickson, V.K., Pedi, L., Long, S.B. 2.85 X-RAY DIFFRACTION 0.234 0.217 False False IGHV1 IGKV12 Kappa 1.5000000000000002e-08 -10.67372125591851 Unknown TBD 6mam A B 0 J | I protein | protein NA | NA envelope glycoprotein | envelope glycoprotein Viral protein/immune system 08/28/18 Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) | zaire ebolavirus (strain mayinga-76) West, B.R., Moyer, C.L., Fusco, M.L., Saphire, E.O. 4.1 X-RAY DIFFRACTION 0.281 0.262 False True IGHV3 IGKV1 Kappa None None None None None 2qr0 B A 0 D protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 2rcj A D 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 7rxl H L 0 E protein NA circumsporozoite protein IMMUNE SYSTEM 08/23/21 Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 1.823 X-RAY DIFFRACTION 0.255 0.207 False True IGHV3 IGLV3 Lambda None None None None None 5kve H L 0 E protein zika envelope diii VIRAL PROTEIN/IMMUNE SYSTEM 07/14/16 Zika specific antibody, ZV-48, bound to ZIKA envelope DIII ZIKA VIRUS; MUS MUSCULUS mus musculus mus musculus zika virus Zhao, H., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 1.7 X-RAY DIFFRACTION 0.213 0.187 False False IGHV1 IGKV8 Kappa 3.5e-08 -10.171711101540176 SPR TBD 3qxu D NA 0 IMMUNE SYSTEM 03/02/11 Free Structure of an Anti-Methotrexate CDR1-3 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.8 X-RAY DIFFRACTION 0.214 0.182 False True IGHV1 None None None None None 3det C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 06/10/08 Structure of the E418A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Jayaram, H., Accardi, A., Wu, F., Williams, C., Miller, C. 2.8 X-RAY DIFFRACTION 0.299 0.255 False False IGHV4 IGKV4 Kappa None None None None None 3ria I O 0 D protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.8 X-RAY DIFFRACTION 0.280 0.266 False True IGHV1 IGLV1 Lambda None None None None None 5usl B C 0 A protein imv membrane protein VIRAL PROTEIN/Immune System 02/13/17 Structure of vaccinia virus D8 protein bound to human Fab vv304 VACCINIA VIRUS; HOMO SAPIENS homo sapiens homo sapiens vaccinia virus Zajonc, D.M. 2.9 X-RAY DIFFRACTION 0.297 0.247 False False IGHV3 IGLV3 Lambda 1.6000000000000003e-11 -14.728215503643927 SPR TBD 7lj4 G F 0 B protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel FHEIG mutant A270P in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.782 X-RAY DIFFRACTION 0.258 0.215 False True IGHV1 IGKV4 Kappa None None None None None 7c2t K L 0 B protein NA envelope protein VIRUS 05/09/20 Helical reconstruction of Zika virus complexed with Fab C10 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Morrone, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Zhang, S., Lok, S.M. 9.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7cmv E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/29/20 Dopamine Receptor D3R-Gi-PD128907 complex HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI mus musculus homo sapiens | homo sapiens Xu, P., Huang, S., Mao, C., Krumm, B., Zhou, X., Tan, Y., Huang, X.-P., Liu, Y., Shen, D.-D., Jiang, Y., Yu, X., Jiang, H., Melcher, K., Roth, B., Cheng, X., Zhang, Y., Xu, H. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5xqy NA G 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 7fg3 D NA 0 A protein NA spike glycoprotein PROTEIN BINDING 07/25/21 Major cryo-EM structure of S protein trimer of SARS-CoV2 with K-874, composite map SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Song, C., Katayama, K., Murata, K. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6okq F E 0 IMMUNE SYSTEM 04/14/19 Crystal structure of the SF12 Fab HOMO SAPIENS homo sapiens homo sapiens Barnes, C.O., Bjorkman, P.J. 3.2 X-RAY DIFFRACTION 0.299 0.273 False True IGHV4 IGKV3 Kappa None None None None None 1nsn H L 0 S protein staphylococcal nuclease COMPLEX (IMMUNOGLOBULIN/HYDROLASE) 06/06/95 THE CRYSTAL STRUCTURE OF ANTIBODY N10-STAPHYLOCOCCAL NUCLEASE COMPLEX AT 2.9 ANGSTROMS RESOLUTION STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Sheriff, S., Bossart-Whitaker, P. 2.8 X-RAY DIFFRACTION unknown 0.195 False False IGHV3 IGKV3 Kappa 1.00e-10 -13.63 Other 1704035 3tyg H L 0 A protein NA envelope glycoprotein gp160 IMMUNE SYSTEM, VIRAL PROTEIN 09/25/11 Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a glycosylated engineered gp120 outer domain with miniV3 (eODmV3) HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pejchal, R., Huang, P.S., Schief, W.R., Stanfield, R.L., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.257 0.207 False True IGHV4 IGLV2 Lambda None None None None None 4aeh H L 0 IMMUNE SYSTEM 01/10/12 Crystal structure of the anti-AaHI Fab9C2 antibody MUS MUSCULUS mus musculus mus musculus Fabrichny, I.P., Mondielli, G., Conrod, S., Martin-Eauclaire, M.F., Bourne, Y., Marchot, P. 1.6 X-RAY DIFFRACTION 0.21359 0.17407 False False IGHV1 IGKV12 Kappa None None None None None 7akj G F 0 C protein NA spike glycoprotein VIRAL PROTEIN 10/01/20 Structure of the SARS-CoV spike glycoprotein in complex with the 47D11 neutralizing antibody Fab fragment SARS CORONAVIRUS WH20; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus wh20 Fedry, J., Hurdiss, D.L., Wang, C., Li, W., Obal, G., Drulyte, I., Howes, S.C., van Kuppeveld, F.J.M., Foerster, F., Bosch, B.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7zmt K NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.5 X-RAY DIFFRACTION 0.288 0.254 False True IGHV1 NA NA None None None None None 5tlk B A 0 X protein cd27 antigen IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.7 X-RAY DIFFRACTION 0.263 0.213 False True IGHV1 IGKV3 Kappa None None None None None 3eys H L 0 Q peptide pyro-glu3-a-beta (3-8) peptide IMMUNE SYSTEM 10/21/08 PFA1 Fab fragment complexed with pyro-Glu3-A-Beta (3-8) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Gardberg, A.S., Dealwis, C.G. 1.95 X-RAY DIFFRACTION 0.256 0.204 False True IGHV8 IGKV1 Kappa 3.00e-06 -7.4 SPR 20 19385664 7lf1 P R 0 J protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6ldw H L 0 C peptide NA ile-phe-glu-lys-phe-gly-m3l-gly-gly IMMUNE SYSTEM 11/23/19 Structure of antibody C9 in complex with methylated peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Tsumoto, K. 1.6 X-RAY DIFFRACTION 0.235 0.171 False True IGHV1 IGKV1 Kappa None None None None None 3idi B A 0 C peptide gp41 mper peptide IMMUNE SYSTEM 07/21/09 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 Fab' fragment in complex with gp41 Peptide ALDKWNQ HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., Pai, E.F. 2.1 X-RAY DIFFRACTION 0.230 0.212 False False IGHV2 IGKV1 Kappa None None None None None 4jfx B A 0 immune system 02/28/13 Structure of phosphotyrosine (pTyr) scaffold bound to pTyr peptide ESCHERICHIA COLI; SYNTHETIC CONSTRUCT Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 1.95 X-RAY DIFFRACTION 0.202 0.163 False True IGHV3 IGKV3 Kappa 3.6000000000000005e-07 -8.790776227275865 Unknown TBD 2rcj B C 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 5mp2 C NA 0 A protein type ii secretion system protein d TRANSPORT PROTEIN 12/15/16 XcpQN012 in complex with VHH04 PSEUDOMONAS AERUGINOSA; LAMA GLAMA lama glama pseudomonas aeruginosa Trinh, T.T.N., Roussel, A., Douzi, B., Voulhoux, R. 2.9 X-RAY DIFFRACTION 0.256 0.213 False True IGHV1 None None None None None 7zwm G H 0 F protein NA gametocyte surface protein p45/48 CELL ADHESION 05/19/22 Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 3.69 X-RAY DIFFRACTION 0.280 0.255 False True IGHV5 IGKV4 Kappa None None None None None 7p5w H NA 0 B protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2r0l H L 0 A protein hepatocyte growth factor activator HYDROLASE, IMMUNE SYSTEM 08/20/07 Short Form HGFA with Inhibitory Fab75 HOMO SAPIENS; HOMO SAPIENS, SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT homo sapiens Eigenbrot, C., Shia, S. 2.2 X-RAY DIFFRACTION 0.248 0.193 False True IGHV3 IGKV1 Kappa 1.46e-08 -10.68 SPR 25 18077410 6iuv C D 0 B protein hemagglutinin IMMUNE SYSTEM 11/30/18 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 3C11 INFLUENZA A VIRUS (A/HONG KONG/482/97(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/hong kong/482/97(h5n1)) Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X. 2.332 X-RAY DIFFRACTION 0.246 0.207 False True IGHV5 IGKV2 Kappa None None None None None 6uuh C D 0 D carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/30/19 Crystal structure of broad and potent HIV-1 neutralizing antibody 438-B11 HOMO SAPIENS; STREPTOCOCCUS SP. 'GROUP G' homo sapiens homo sapiens homo sapiens Kumar, S., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.260 0.227 False True unknown IGKV3 Kappa None None None None None 4rfe E F 0 IMMUNE SYSTEM 09/25/14 Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab MACACA MULATTA macaca mulatta macaca mulatta Wu, X., Gohain, N., Tolbert, W.D., Pazgier, M. 1.91 X-RAY DIFFRACTION 0.246 0.192 False True IGHV4 IGLV1 Lambda None None None None None 7czx H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B9 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV4 Kappa None None None None None 2g75 A B 0 IMMUNE SYSTEM 02/27/06 Crystal Structure of anti-SARS m396 Antibody HOMO SAPIENS homo sapiens homo sapiens Prabakaran, P., Gan, J.H., Feng, Y., Zhu, Z.Y., Xiao, X.D., Ji, X., Dimitrov, D.S. 2.28 X-RAY DIFFRACTION 0.277 0.221 False True IGHV1 IGLV3 Lambda None None None None None 5x2q H L 0 A | B protein | protein NA | NA taste receptor, type 1, member 2a | taste receptor, type 1, member 3 SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with glycine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes | oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.6 X-RAY DIFFRACTION 0.230 0.154 False True IGHV1 IGKV3 Kappa None None None None None 4q0x H L 0 E peptide envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 04/02/14 Crystal structure of non-neutralizing antibody in complex with Epitope II of HCV E2 HEPATITIS C VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis c virus Deng, L., Zhang, P. 2.9 X-RAY DIFFRACTION 0.285 0.221 False False IGHV1 IGKV1 Kappa None None None None None 7pi7 E F 0 D protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to monoclonal antibody Cy.002 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 2.72 X-RAY DIFFRACTION 0.301 0.273 False True IGHV14 IGKV3 Kappa None None None None None 1lmk G g 0 IMMUNOGLOBULIN 08/29/94 THE STRUCTURE OF A BIVALENT DIABODY MUS MUSCULUS mus musculus Williams, R.L. 2.6 X-RAY DIFFRACTION unknown 0.200 True True unknown unknown unknown None None None None None 7q9m H L 0 C protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-53 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 6xob S T 0 K protein NA togavirin Virus/Immune System 07/06/20 CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP with Fab EEEV-143. EASTERN EQUINE ENCEPHALITIS VIRUS; HOMO SAPIENS homo sapiens homo sapiens eastern equine encephalitis virus Binshtein, E., Crowe, J.E. 8.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6y1k H L 0 NA NA NA NA IMMUNE SYSTEM 02/12/20 Crystal structure of the unmodified A.17 antibody FAB fragment - L47R mutant HOMO SAPIENS homo sapiens homo sapiens Chatziefthimiou, S., Stepanova, A., Mokrushina, Y., Smirnov, I., Gabibov, A., Wilmanns, M. 1.65 X-RAY DIFFRACTION 0.217 0.185 False True IGHV4 IGLV1 Lambda None None None None None 6vy2 I M 0 C protein glycoprotein 120 IMMUNE SYSTEM 02/25/20 Cryo-EM structure of M1214_N1 Fab in complex with CH505 TF chimeric SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 4.86 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 3iy6 B A 0 IMMUNE SYSTEM 04/09/09 Variable domains of the computer generated model (WAM) of Fab E fitted into the cryoEM reconstruction of the virus-Fab E complex RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Chipman, P.R., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 12 ELECTRON MICROSCOPY False False IGHV2 IGKV6 Kappa None None None None None 1maj NA A 3 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6mam E F 0 H | G protein | protein NA | NA envelope glycoprotein | envelope glycoprotein Viral protein/immune system 08/28/18 Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) | zaire ebolavirus (strain mayinga-76) West, B.R., Moyer, C.L., Fusco, M.L., Saphire, E.O. 4.1 X-RAY DIFFRACTION 0.281 0.262 False True IGHV3 IGKV1 Kappa None None None None None 4tsb H L 0 A protein lysozyme c Immune system/hydrolase 06/18/14 Structure of a lysozyme antibody complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Wensley, B. 1.95 X-RAY DIFFRACTION 0.227 0.194 False True IGHV3 IGLV1 Lambda None None None None None 7pg8 L J 0 C protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 2a9n H L 0 H Hapten ORE 4-(2,7-DIFLUORO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)ISOPHTHALIC ACID Immune System 07/12/05 A Mutation Designed to Alter Crystal Packing Permits Structural Analysis of a Tight-binding Fluorescein-scFv complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cambillau, C., Spinelli, S., Honegger, A., Pluckthun, A. 3.0 X-RAY DIFFRACTION 0.266 0.217 True True IGHV3 IGLV1 Lambda None None None None None 2qr0 F E 0 C protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 2nxz D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.04 X-RAY DIFFRACTION 0.244 0.206 False True IGHV1 IGKV3 Kappa 5.29e-07 SPR 17301785 1pg7 Z Y 0 IMMUNE SYSTEM 05/27/03 Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab SYNTHETIC CONSTRUCT; MUS MUSCULUS mus musculus mus musculus Eigenbrot, C., Meng, Y.G., Krishnamurthy, R., Lipari, M.T., Presta, L., Devaux, B., Wong, T., Moran, P., Bullens, S., Kirchhofer, D. 2.5 X-RAY DIFFRACTION 0.265 0.217 False False IGHV1 IGLV1 Lambda None None None None None 4n1e NA E 0 K protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 6h3h C D 0 IMMUNE SYSTEM 07/18/18 Fab fragment of antibody against fullerene C60 MUS MUSCULUS mus musculus mus musculus Osipov, E.M., Tikhonova, T.V. 1.92 X-RAY DIFFRACTION 0.234 0.188 False False IGHV1 IGLV1 Lambda None None None None None 6qd6 D NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 3ijy B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 08/05/09 Structure of S67-27 in Complex with Kdo(2.8)Kdo MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.85 X-RAY DIFFRACTION 0.284 0.237 False False IGHV7 IGKV8 Kappa 9.1e-07 -8.241342074897947 Unknown TBD 7r40 E G 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/08/22 Structure of the SARS-CoV-2 spike glycoprotein in complex with the 87G7 antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hurdiss, D.L. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7f9z E e 0 A protein NA engineered g-alpha-q MEMBRANE PROTEIN 07/05/21 GHRP-6-bound ghrelin receptor in complex with Gq HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT mus musculus homo sapiens Wang, Y., Zhuang, Y., Xu, P., Xu, H.E., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3c2a H L 0 P peptide envelope glycoprotein IMMUNE SYSTEM 01/24/08 Antibody Fab fragment 447-52D in complex with UG1033 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Dhillon, A.K., Stanfield, R.L., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.298 0.240 False False IGHV3 IGLV1 Lambda None None None None None 6tyl C NA 0 A protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 08/09/19 Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., McClelland, L., Yates-Hansen, C., Sprang, S.R. 3.3 X-RAY DIFFRACTION 0.287 0.248 False True IGHV1 None None None None None 7urq H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/22/22 Crystal Structure of SARS-CoV-2 S delta variant receptor-binding domain (RBD) in complex CoV11 Fab crystal form 1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tolbert, W.D., Pazgier, M. 2.05 X-RAY DIFFRACTION 0.208 0.177 False True IGHV3 IGKV3 Kappa None None None None None 6d0u E F 0 A protein hemagglutinin ANTIVIRAL PROTEIN 04/11/18 Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Wu, N.C., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.268 0.254 False True IGHV3 IGKV1 Kappa None None None None None 5icz D C 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with GQFDLSTRRLKG peptide MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.55 X-RAY DIFFRACTION 0.221 0.171 False True IGHV2 IGKV5 Kappa 5e-06 -7.231898839371053 Unknown TBD 6sc6 C NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR apo structure HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., House, D., Rittinger, K. 2.25 X-RAY DIFFRACTION 0.246 0.199 False True IGHV3 None None None None None 6cdi q r 0 d protein unknown VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False False unknown IGKV3 Kappa None None None None None 7m7h C D 0 A protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 chimera BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1' SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7zfc M NA 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Beta RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs HOMO SAPIENS; LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.24 X-RAY DIFFRACTION 0.299 0.244 False True IGHV1 NA NA None None None None None 7q9j J K 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-26 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 6ddr B A 0 C protein mhc class i polypeptide-related sequence a IMMUNE SYSTEM 05/10/18 Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Matsumoto, M.L. 1.9 X-RAY DIFFRACTION 0.247 0.208 False True IGHV1 IGKV12 Kappa 9.4e-10 -12.314856971588666 ITC TBD 5uty D E 0 B protein hiv-1 bg505 strain env gp41 VIRAL PROTEIN/immune system 02/15/17 Crystal Structure of a Stabilized DS-SOSIP.mut4 BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, N300M, N302M, T320L in Complex with Human Antibodies PGT122 and 35O22 at 4.1 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Chuang, G.-Y., Pancera, M., Kwong, P.D. 3.412 X-RAY DIFFRACTION 0.288 0.241 False True unknown unknown unknown None None None None None 6vmk u t 0 v protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False False IGHV1 IGKV1 Kappa None None None None None 6n1w 8 7 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 3o45 A B 0 C peptide fusion glycoprotein f1 IMMUNE SYSTEM/VIRAL PROTEIN 07/26/10 Crystal Structure of 101F Fab Bound to 17-mer Peptide Epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus McLellan, J.S., Chen, M., Chang, J.S., Yang, Y., Kim, A., Graham, B.S., Kwong, P.D. 2.872 X-RAY DIFFRACTION 0.254 0.200 False True IGHV8 IGKV3 Kappa None None None None None 6wg2 I M 0 P peptide NA npna4 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab239 in complex with NPNA4 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 2.534 X-RAY DIFFRACTION 0.246 0.195 False True IGHV3 IGKV1 Kappa None None None None None 5nj3 C D 0 B protein atp-binding cassette sub-family g member 2 TRANSPORT PROTEIN 03/28/17 Structure of an ABC transporter: complete structure MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Taylor, N.M.I., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P. 3.78 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 6oz6 E NA 0 A protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to 3'-hydroxymureidomycin A LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.7 X-RAY DIFFRACTION 0.301 0.257 False True IGHV1 None None None None None 5xqy NA D 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 7buf G I 0 B protein dengue virus serotype 2 e protein VIRUS 05/13/20 Cryo-EM structure of Dengue virus serotype 2 complexed with SIgN-3C IgG HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 6.1 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6ol7 M N 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV1 IGKV3 Kappa None None None None None 5o03 C NA 0 A protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 protruding domain in complex with Nanobody Nano-32 NORWALK VIRUS; NOROVIRUS norovirus norwalk virus Koromyslova, A.D., Hansman, G.H. 2.194 X-RAY DIFFRACTION 0.193 0.172 False True IGHV1 6.000000000000001e-08 -9.85236447127895 ITC TBD 7sob H J 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4zyp J L 0 C protein fusion glycoprotein f0,fibritin IMMUNE SYSTEM 05/21/15 Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS mus musculus mus musculus human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 5.5 X-RAY DIFFRACTION 0.277 0.211 False True IGHV2 IGKV1 Kappa None None None None None 4uif I J 0 E protein dengue virus serotype 2 strain pvp94 07 - envelopeprotein 03/30/15 Cryo-EM structure of Dengue virus serotype 2 in complex with antigen- binding fragments of human antibody 2D22 DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.-N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Junior, J.E., Lok, S.-M. 6.5 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 3ixt A B 0 C peptide fusion glycoprotein f1 IMMUNE SYSTEM 09/04/09 Crystal Structure of Motavizumab Fab Bound to Peptide Epitope MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS mus musculus mus musculus human respiratory syncytial virus McLellan, J.S., Chen, M., Kim, A., Yang, Y., Graham, B.S., Kwong, P.D. 2.75 X-RAY DIFFRACTION 0.274 0.213 False True IGHV2 IGKV1 Kappa 2.41e-07 -9.02 SPR 20098425 1dbk H L 0 H Hapten ANO 5-BETA-ANDROSTANE-3,17-DIONE IMMUNOGLOBULIN 08/24/93 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY MUS MUSCULUS mus musculus mus musculus mus musculus Arevalo, J.H., Wilson, I.A. 3.0 X-RAY DIFFRACTION unknown 0.213 False True IGHV9 IGKV1 Kappa None None None None None 5ja8 H NA 0 G protein toxin higb-2 TOXIN 04/12/16 Crystal structure of the HigB2 toxin in complex with Nb2 LAMA GLAMA; VIBRIO CHOLERAE SEROTYPE O1 (STRAIN ATCC 39315 / EL TOR INABA N16961) lama glama vibrio cholerae serotype o1 (strain atcc 39315/ el tor inaba n16961) Hadzi, S., Loris, R. 2.49 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 None None None None None 6xmi B A 0 C peptide NA terminase, large subunit VIRAL PROTEIN, IMMUNE SYSTEM 06/30/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 1.51 X-RAY DIFFRACTION 0.203 0.167 False True IGHV3 IGKV1 Kappa None None None None None 4plk J K 0 E protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 05/18/14 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12 HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Li, S.W., Sivaraman, J. 4.0 X-RAY DIFFRACTION 0.296 0.264 False False IGHV1 IGKV12 Kappa None None None None None 7t3d H L 0 B protein NA hemagglutinin ha2 chain Viral Protein/IMMUNE SYSTEM 12/07/21 CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA INFLUENZA A VIRUS (A/CALIFORNIA/04/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009(h1n1)) Han, J., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 3cdc NA B 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 6c6x A B 0 IMMUNE SYSTEM 01/19/18 Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque. MACACA MULATTA macaca mulatta macaca mulatta Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.208 0.176 False True IGHV4 IGKV1 Kappa None None None None None 7n8i H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/14/21 SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 (Local Refinement of the NTD/S2L20) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ora D E 0 C protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the T478K mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-45 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.6 X-RAY DIFFRACTION 0.245 0.204 False True IGHV3 IGKV1 Kappa None None None None None 7djy D NA 0 NA NA NA NA BIOSYNTHETIC PROTEIN 11/22/20 Clec4f Nanobody 322 LAMIUM MACULATUM lamium maculatum Wen, Y., Zheng, F. 2.7 X-RAY DIFFRACTION 0.266 0.228 False True IGHV1 NA NA None None None None None 7nk1 F NA 0 NA NA NA NA VIRAL PROTEIN 02/17/21 1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201 INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.22 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7czt I M 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2G9 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV5 Lambda None None None None None 6zer F G 0 D protein NA rbd VIRAL PROTEIN/IMMUNE SYSTEM 06/16/20 Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 3.8 X-RAY DIFFRACTION 0.251 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6b0w H L 0 IMMUNE SYSTEM 09/15/17 Crystal structure of the anti-circumsporozoite protein 1710 antibody HOMO SAPIENS homo sapiens homo sapiens Scally, S.W., Murugan, R., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 1.9 X-RAY DIFFRACTION 0.218 0.183 False True IGHV3 IGLV3 Lambda None None None None None 1p2c B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 04/15/03 crystal structure analysis of an anti-lysozyme antibody MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Cauerhff, A., Goldbaum, F.A., Braden, B.C. 2.0 X-RAY DIFFRACTION 0.242 0.204 False False IGHV1 IGKV5 Kappa 9.80e-11 -13.65 SPR 25 14988501 6j7w B NA 0 D peptide tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/18/19 Crystal Structure of Human BCMA in complex with UniAb(TM) VH HOMO SAPIENS homo sapiens homo sapiens Clarke, S.C., Ma, B., Trinklein, N.D., Schellenberger, U., Osborn, M., Ouisse, L., Boudreau, A., Davison, L., Harris, K.E., Ugamraj, H., Balasubramani, A., Dang, K., Jorgensen, B., Ogana, H., Pham, D., Pratap, P., Sankaran, P., Anegon, I., van Schooten, W., Bruggemann, M., Buelow, R., Force Aldred, S. 2.6 X-RAY DIFFRACTION 0.271 0.209 False True IGHV3 None None None None None 1a0q H L 0 CATALYTIC ANTIBODY 12/05/97 29G11 COMPLEXED WITH PHENYL [1-(1-N-SUCCINYLAMINO)PENTYL] PHOSPHONATE MUS MUSCULUS mus musculus mus musculus Buchbinder, J.L., Stephenson, R.C., Scanlan, T.S., Fletterick, R.J. 2.3 X-RAY DIFFRACTION 0.275 0.203 False False IGHV1 IGKV19 Kappa None None None None None 5m6a NA A 0 IMMUNE SYSTEM 10/24/16 Crystal structure of cardiotoxic Bence-Jones light chain dimer H9 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 1.64 X-RAY DIFFRACTION 0.203 0.183 False False IGLV2 Lambda None None None None None 6eti F E 0 A protein atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 10/26/17 Structure of inhibitor-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Altmann, K.H., Locher, K.P. 3.1 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 3kyk H L 0 IMMUNE SYSTEM 12/06/09 Crystal structure of li33 Igg1 Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 3.2 X-RAY DIFFRACTION 0.290 0.194 False True IGHV3 IGKV3 Kappa None None None None None 7q9p H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-06 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7k8m A B 0 E protein NA surface glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C110 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Jette, C.A., Barnes, C.O., Bjorkman, P.J. 3.2 X-RAY DIFFRACTION 0.234 0.175 False True IGHV3 IGKV3 Kappa None None None None None 4npy B A 0 IMMUNE SYSTEM 11/22/13 Crystal structure of germline Fab PGT121, a putative precursor of the broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Diwanji, D.C., Wilson, I.A. 1.796 X-RAY DIFFRACTION 0.220 0.182 False True IGHV4 IGLV3 Lambda None None None None None 7bz5 H L 0 A protein spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 05/13/20 Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wu, Y., Qi, J., Gao, F. 1.84 X-RAY DIFFRACTION 0.191 0.167 False True IGHV3 IGKV1 Kappa None None None None None 2bx5 NA O 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 6i3z H L 0 A | B protein | peptide NA | NA alpha-1-antitrypsin | alpha-1-antitrypsin PROTEIN BINDING 11/08/18 Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Laffranchi, M., Elliston, E.L.K., Miranda, E., Perez, J., Jagger, A.M., Fra, A., Lomas, D.A., Irving, J.A. 3.1 X-RAY DIFFRACTION 0.307 0.261 False False IGHV5 IGKV14 Kappa None None None None None 7nk8 F NA 0 A | B protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit VIRAL PROTEIN 02/17/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8205 core CAMELIDAE MIXED LIBRARY; INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (a/brevigmission/1/1918(h1n1)) | influenza a virus (a/brevigmission/1/1918(h1n1)) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 5.34 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4dkf I M 0 B protein interleukin-34 CYTOKINE/IMMUNE SYSTEM 02/03/12 Crystal Structure of Human Interleukin-34 Bound to FAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ma, X., Chen, Y., Stawicki, S., Wu, Y., Bazan, J.F., Starovasnik, M.A. 2.61 X-RAY DIFFRACTION 0.256 0.225 False True IGHV3 IGKV1 Kappa 3.1000000000000005e-09 -11.607859518116271 SPR TBD 6w03 D E 0 B protein envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 02/28/20 Crystal Structure of HIV-1 BG505 DS-SOSIP.3mut Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.3 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.273 0.230 False True unknown unknown unknown None None None None None 3gje B A 0 IMMUNE SYSTEM 03/08/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS homo sapiens homo sapiens Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E., Kleber, S., Stenner-Liewen, F., Bauer, S., McMichael, A., Knuth, A., Abken, H., Hombach, A.A., Cerundolo, V., Jones, E.Y., Renner, C. 2.3 X-RAY DIFFRACTION 0.302 0.222 False True IGHV3 IGLV2 Lambda None None None None None 5da0 B NA 0 A protein sulphate transporter TRANSPORT PROTEIN 08/19/15 Structure of the the SLC26 transporter SLC26Dg in complex with a nanobody DEINOCOCCUS GEOTHERMALIS (STRAIN DSM 11300); LAMA GLAMA lama glama deinococcus geothermalis (strain dsm 11300) Dutzler, R., Geertsma, E.R., Chang, Y., Shaik, F.R. 3.2 X-RAY DIFFRACTION 0.308 0.258 False True IGHV1 None None None None None 5f7m C NA 0 A protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.72 X-RAY DIFFRACTION 0.218 0.179 False True IGHV1 None None None None None 4zto I M 0 Q peptide epitope of rabbit monoclonal antibody r53 IMMUNE SYSTEM 05/14/15 Fab/epitope complex structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R., Kong, X.-P. 2.3 X-RAY DIFFRACTION 0.223 0.167 False True IGHV1 IGKV1 Kappa None None None None None 5wdu L K 0 F protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True IGHV4 unknown unknown None None None None None 5x2m J K 0 C | D protein | protein NA | NA taste receptor, type 1, member 2a | taste receptor, type 1, member 3 SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-glutamine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes | oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.206 X-RAY DIFFRACTION 0.227 0.173 False True IGHV1 IGKV3 Kappa None None None None None 3iy7 B A 0 IMMUNE SYSTEM 04/09/09 Variable domains of the computer generated model (WAM) of Fab F fitted into the cryoEM reconstruction of the virus-Fab F complex RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Chipman, P.R., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 14 ELECTRON MICROSCOPY False False IGHV2 IGKV22 Kappa None None None None None 3ghb I M 0 Q peptide envelope glycoprotein IMMUNE SYSTEM 03/03/09 Crystal structure of anti-HIV-1 Fab 447-52D in complex with V3 peptide W2RW020 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.P., Burke, V.J. 2.25 X-RAY DIFFRACTION 0.232 0.196 False False IGHV3 IGLV1 Lambda None None None None None 2wzp D NA 0 B protein putative receptor binding protein VIRAL PROTEIN 12/01/09 Structures of Lactococcal Phage p2 Baseplate Shed Light on a Novel Mechanism of Host Attachment and Activation in Siphoviridae LACTOCOCCUS PHAGE P2; LAMA GLAMA lama glama lactococcus phage p2 Sciara, G., Bebeacua, C., Bron, P., Tremblay, D., Ortiz-Lombardia, M., Lichiere, J., van Heel, M., Campanacci, V., Moineau, S., Cambillau, C. 2.6 X-RAY DIFFRACTION 0.2078 0.1789 False True IGHV1 None None None None None 3cm9 C N 6 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6o89 H NA 0 NA NA NA NA IMMUNE SYSTEM 03/09/19 Anti-CD28xCD3 CODV Fab HOMO SAPIENS homo sapiens Lord, D.M., Wei, R.R. 2.09 X-RAY DIFFRACTION 0.222 0.178 False True IGHV3 NA NA None None None None None 7k39 H G 0 A | B protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation A, neutral pH-like INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7aej D NA 0 A protein NA envelope glycoprotein gp160,envelope glycoprotein gp160 VIRAL PROTEIN 09/17/20 Crystal structure of asymmetric HIV-1 gp41 containing all membrane anchors HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Caillat, C., Guilligay, D., Weissenhorn, W. 3.8 X-RAY DIFFRACTION 0.308 0.265 False True IGHV1 NA NA None None None None None 4aq1 D NA 0 STRUCTURAL PROTEIN 04/12/12 Structure of the SbsB S-layer protein of Geobacillus stearothermophilus PV72p2 in complex with nanobody KB6 GEOBACILLUS STEAROTHERMOPHILUS; LAMA GLAMA lama glama Baranova, E., Remaut, H. 2.42 X-RAY DIFFRACTION 0.23567 0.18301 False True IGHV1 None None None None None 6wkm H L 0 NA NA NA NA IMMUNE SYSTEM 04/16/20 Fab Fragment of Anti-human LAG3 antibody (22D2) MUS MUSCULUS mus musculus mus musculus Agnihotri, P., Mishra, A.K., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.235 0.203 False True IGHV1 IGKV3 Kappa None None None None None 3k3q A NA 0 C | B protein | protein NA | NA botulinum neurotoxin type a | botulinum neurotoxin type a IMMUNE SYSTEM 10/04/09 Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain LAMA GLAMA; CLOSTRIDIUM BOTULINUM A STR. HALL lama glama clostridium botulinum a str. hall | clostridium botulinum a str. hall Thompson, A.A., Dong, J., Marks, J.D., Stevens, R.C. 2.6 X-RAY DIFFRACTION 0.256 0.218 False True unknown unknown unknown None None None None None 7p78 D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 1up/1up-out/1down conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5ob5 H L 0 A protein c-x-c motif chemokine 2 IMMUNE SYSTEM 06/26/17 fAb complex with GroBeta. AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhao, B., Ward, P., Convery, M.A. 1.65 X-RAY DIFFRACTION 0.195 0.168 False True IGHV1 IGKV14 Kappa None None None None None 7bel H L 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-88 and COVOX-45 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.53 X-RAY DIFFRACTION 0.286 0.249 False True IGHV4 IGLV1 Lambda None None None None None 3u46 H L 0 IMMUNE SYSTEM 10/07/11 CH04H/CH02L P212121 HOMO SAPIENS homo sapiens homo sapiens Louder, R., Pancera, M., McLellan, J.S., Kwong, P.D. 2.906 X-RAY DIFFRACTION 0.245 0.215 False True IGHV3 IGKV3 Kappa None None None None None 3cm9 B M 6 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4z7n H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 Membrane protein/Immune system 04/07/15 Integrin alphaIIbbeta3 in complex with AGDV peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Lin, F.-Y., Zhu, J., Springer, T.A. 2.599 X-RAY DIFFRACTION 0.253 0.230 False True IGHV14 IGKV14 Kappa None None None None None 5m2m F NA 0 A protein tumor necrosis factor CYTOKINE 10/13/16 Complex between human TNF alpha and Llama VHH3 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.3 X-RAY DIFFRACTION 0.248 0.211 False True IGHV1 1.5000000000000002e-09 -12.037965345328766 SPR TBD 1qfu H L 0 A protein protein (hemagglutinin (ha1 chain)) Viral protein/Immune system 04/14/99 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Fleury, D., Gigant, B., Bizebard, T., Daniels, R.S., Skehel, J.J., Knossow, M. 2.8 X-RAY DIFFRACTION 0.284 0.198 False False IGHV1 IGKV1 Kappa 3.00E-09 -11.5 SPR 22 10360354 6p50 H L 0 C protein NA interleukin-7 receptor subunit alpha IMMUNE SYSTEM 05/29/19 Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Walsh, S.T.R., Kashi, L., Kohnhorst, C.L. 2.9 X-RAY DIFFRACTION 0.330 0.286 False False IGHV1 IGKV19 Kappa None None None None None 2kh2 B b 24 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 2qtj C O 7 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 1it9 H L 0 IMMUNE SYSTEM 01/11/02 CRYSTAL STRUCTURE OF AN ANTIGEN-BINDING FRAGMENT FROM A HUMANIZED VERSION OF THE ANTI-HUMAN FAS ANTIBODY HFE7A MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Ito, S., Takayama, T., Hanzawa, H., Takahashi, T., Miyadai, K., Serizawa, N., Hata, T., Haruyama, H. 2.8 X-RAY DIFFRACTION 0.280 0.202 False True IGHV1 IGKV3 Kappa None None None None None 4p59 H L 0 A protein receptor tyrosine-protein kinase erbb-3 Signaling protein, immune system 03/15/14 HER3 extracellular domain in complex with Fab fragment of MOR09825 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Sprague, E.R. 3.4 X-RAY DIFFRACTION 0.250 0.184 False True IGHV3 IGKV1 Kappa 3.2e-11 -14.317537111324148 Solution Equilibrium Titration TBD 5u0u E e 0 IMMUNE SYSTEM 11/27/16 Crystal Structure of DH270.1 (unliganded, single-chain Fv) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens Fera, D., Harrison, S.C. 3.428 X-RAY DIFFRACTION 0.282 0.254 True True unknown unknown unknown None None None None None 6war F NA 0 E protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 3lve NA A 0 IMMUNOGLOBULIN 05/12/98 LEN Q38E MUTANT: A DOMAIN FLIP FROM A SINGLE AMINO ACID SUBSTITUTION HOMO SAPIENS homo sapiens Schiffer, M., Pokkuluri, P.R. 2.0 X-RAY DIFFRACTION 0.248 0.176 False True unknown unknown unknown None None None None None 6vi0 K J 0 I protein NA bg505 gp120 IMMUNE SYSTEM 01/10/20 Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.43 ELECTRON MICROSCOPY NA NA False True unknown IGKV3 Kappa None None None None None 6bpa E F 0 D protein reticulocyte binding protein 2, putative CELL INVASION 11/22/17 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 3E9 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus mus musculus plasmodium vivax (strain salvador i) Gruszczyk, J., Chan, L.J., Tham, W.H. 2.53 X-RAY DIFFRACTION 0.225 0.194 False False IGHV14 IGKV17 Kappa None None None None None 7xod Z NA 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 05/01/22 SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA lama glama Xu, Y., Wu, C., Liu, H., Yin, W., Xu, H.E. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6cyf F E 0 B protein type iii secretion system protein IMMUNE SYSTEM 04/05/18 PcrV fragment with bound Fab PSEUDOMONAS AERUGINOSA; HOMO SAPIENS homo sapiens homo sapiens pseudomonas aeruginosa Oganesyan, V. 2.78 X-RAY DIFFRACTION 0.249 0.215 False True IGHV3 IGKV1 Kappa None None None None None 1t66 D C 0 C Hapten FLU 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID IMMUNE SYSTEM 05/05/04 The structure of FAB with intermediate affinity for fluorescein. MUS MUSCULUS mus musculus mus musculus mus musculus Terzyan, S., Ramsland, P.A., Voss Jr., E.W., Herron, J.N., Edmundson, A.B. 2.3 X-RAY DIFFRACTION 0.253 0.204 False False IGHV6 IGKV1 Kappa None None None None None 5udd K Q 0 C | B protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F B9320 Bound to MEDI8897 HUMAN RESPIRATORY SYNCYTIAL VIRUS 9320; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus 9320 | human respiratory syncytial virus 9320 McLellan, J.S. 4.3 X-RAY DIFFRACTION 0.295 0.237 False True IGHV1 IGKV1 Kappa None None None None None 6rcu B C 0 A protein reticulocyte binding protein homologue 5 CELL ADHESION 04/11/19 PfRH5 bound to monoclonal antibodies R5.004 and R5.016 PLASMODIUM FALCIPARUM (ISOLATE 3D7); HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Alanine, D.W.G., Draper, S.J., Higgins, M.K. 4.005 X-RAY DIFFRACTION 0.339 0.285 False True IGHV1 IGLV1 Lambda None None None None None 7mf9 C D 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA Fab in space group C2 HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 3.7 X-RAY DIFFRACTION 0.269 0.240 False True IGHV3 IGLV3 Lambda None None None None None 1jto A NA 0 L protein NA lysozyme Antibody,Hydrolase 08/21/01 Degenerate interfaces in antigen-antibody complexes CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L. 2.5 X-RAY DIFFRACTION 0.240 0.173 False True IGHV1 NA NA None None None None None 7s11 J N 0 E protein NA t-cell surface protein tactile IMMUNE SYSTEM 08/31/21 Crystal structure of Fab in complex with mouse CD96 monomer MUS MUSCULUS; RATTUS rattus rattus mus musculus Lee, P.S., Chau, B., Strop, P. 2.58 X-RAY DIFFRACTION 0.279 0.226 False True IGHV2 IGLV1 Lambda None None None None None 4tnv I O 0 D protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False IGHV1 IGLV1 Lambda None None None None None 7ew7 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of SEW2871-bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Jia, G.W., Yuan, Y., Su, Z.M., Shao, Z.H. 3.27 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7rth m NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 6ch7 D E 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 02/22/18 XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.8 X-RAY DIFFRACTION 0.262 0.232 False True unknown unknown unknown None None None None None 4oqt H L 0 A protein leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 02/10/14 LINGO-1/Li81 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pepinsky, R.B., Arndt, J.W., Quan, C., Gao, Y., Quintero-Monzon, O., Lee, X., Mi, S. 3.23 X-RAY DIFFRACTION 0.256 0.192 False True IGHV3 IGKV3 Kappa None None None None None 2i9l B A 0 I protein virion membrane protein m25 IMMUNE SYSTEM/VIRAL PROTEIN 09/05/06 Structure of Fab 7D11 from a neutralizing antibody against the poxvirus L1 protein VACCINIA VIRUS; MUS MUSCULUS mus musculus mus musculus vaccinia virus Su, H.P., Golden, J.W., Gittis, A.G., Moss, B., Hooper, J.W., Garboczi, D.N. 3.1 X-RAY DIFFRACTION 0.259 0.240 False False IGHV1 IGKV8 Kappa None None None None None 6ss0 H L 0 NA NA NA NA PROTEIN BINDING 09/06/19 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021181 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 1.7 X-RAY DIFFRACTION 0.224 0.189 False False IGHV3 IGLV1 Lambda None None None None None 6vmj J I 0 X protein NA complement factor d HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 2.95 X-RAY DIFFRACTION 0.265 0.218 False True IGHV1 IGKV1 Kappa None None None None None 1wz1 H L 0 IMMUNE SYSTEM 02/21/05 Crystal structure of the Fv fragment complexed with dansyl-lysine MUS MUSCULUS mus musculus mus musculus Nakasako, M., Oka, T., Mashumo, M., Takahashi, H., Shimada, I., Yamaguchi, Y., Kato, K., Arata, Y. 1.85 X-RAY DIFFRACTION 0.253 0.216 False True IGHV6 IGKV1 Kappa None None None None None 6ehg C NA 0 B | A protein | protein NA | NA complement c3 | complement c3 IMMUNE SYSTEM 09/13/17 complement component C3b in complex with a nanobody LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Jensen, R.K., Andersen, K.R., Gadeberg, T.A.F., Laursen, N.S., Andersen, G.R. 2.65 X-RAY DIFFRACTION unknown unknown False True IGHV1 2.4e-10 -13.12373995487015 SPR TBD 2a6j H L 0 IMMUNE SYSTEM 07/02/05 Crystal structure analysis of the anti-arsonate germline antibody 36-65 MUS MUSCULUS mus musculus mus musculus Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M. 2.7 X-RAY DIFFRACTION 0.265 0.225 False False IGHV1 IGKV10 Kappa None None None None None 6vy4 C D 0 B protein NA receptor binding protein VIRAL PROTEIN/IMMUNE SYSTEM 02/25/20 Crystal structure of Hendra receptor binding protein head domain in complex with human neutralizing antibody HENV-32 HENDRA HENIPAVIRUS; HOMO SAPIENS homo sapiens homo sapiens hendra henipavirus Dong, J., Crowe, J.E. 2.0 X-RAY DIFFRACTION 0.226 0.183 False True IGHV1 IGLV3 Lambda None None None None None 6xw5 C NA 0 A protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5820 MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 1.72 X-RAY DIFFRACTION 0.191 0.161 False True IGHV1 None None None None None 7zr9 F G 0 B protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/03/22 OMI-2 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2fjf V U 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 4x7e D NA 0 B protein capsid protein VIRAL PROTEIN 12/09/14 Crystal structure of norovirus GII.10 P domain in complex with Nano-85 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Hansman, G.H., Koromyslova, A.D. 2.11 X-RAY DIFFRACTION 0.218 0.189 False True IGHV1 7.000000000000001e-09 -11.125276798630649 ITC TBD 7lm8 M N 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/05/21 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with two cross-neutralizing antibodies CV38-142 and COVA1-16 Fabs isolated from COVID-19 patients SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 1.936 X-RAY DIFFRACTION 0.201 0.169 False True IGHV5 IGKV1 Kappa None None None None None 7pi7 B C 0 A protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to monoclonal antibody Cy.002 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 2.72 X-RAY DIFFRACTION 0.301 0.273 False True IGHV14 IGKV3 Kappa None None None None None 5my4 B A 0 C peptide pyroglutamate-abeta pe3-12-pegb IMMUNE SYSTEM 01/25/17 Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Parthier, C., Piechotta, A., Stubbs, M.T. 2.211 X-RAY DIFFRACTION 0.250 0.186 False True IGHV5 IGKV1 Kappa None None None None None 1osp H L 0 O protein outer surface protein a COMPLEX (IMMUNOGLOBULIN/LIPOPROTEIN) 11/23/96 CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB BORRELIA BURGDORFERI; MUS MUSCULUS mus musculus mus musculus borrelia burgdorferi Li, H., Lawson, C.L. 1.95 X-RAY DIFFRACTION 0.295 0.229 False False IGHV3 IGKV13 Kappa None None None None None 1rhh D C 0 IMMUNE SYSTEM 11/14/03 Crystal Structure of the Broadly HIV-1 Neutralizing Fab X5 at 1.90 Angstrom Resolution HOMO SAPIENS homo sapiens homo sapiens Darbha, R., Phogat, S., Labrijn, A.F., Shu, Y., Gu, Y., Andrykovitch, M., Zhang, M.Y., Pantophlet, R., Martin, L., Vita, C., Burton, D.R., Dimitrov, D.S., Ji, X. 1.9 X-RAY DIFFRACTION 0.227 0.224 False True IGHV1 IGKV3 Kappa None None None None None 7lia B C 0 A protein NA sodium-dependent serotonin transporter MEMBRANE PROTEIN 01/26/21 5-HT bound serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in outward facing conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Gouaux, E. 3.3 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 6m87 B A 0 B Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 08/21/18 Fab 10A6 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.609 X-RAY DIFFRACTION 0.265 0.228 False False IGHV1 IGKV4 Kappa None None None None None 5uix H L 0 IMMUNE SYSTEM 01/15/17 Crystal Structure of the DH576 CD4bs Fab (unliganded) from the RV305 HIV Vaccine Trial HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.501 X-RAY DIFFRACTION 0.250 0.211 False True IGHV3 IGKV1 Kappa None None None None None 2arj H L 0 Q protein t-cell surface glycoprotein cd8 alpha chain Immune System 08/19/05 CD8alpha-alpha in complex with YTS 105.18 Fab MUS MUSCULUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Shore, D.A., Teyton, L., Dwek, R.A., Rudd, P.M., Wilson, I.A. 2.88 X-RAY DIFFRACTION 0.277 0.220 False False IGHV2 IGKV6 Kappa None None None None None 6ehy B b 0 IMMUNE SYSTEM 09/15/17 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery HOMO SAPIENS homo sapiens Hargreaves, D. 2.25 X-RAY DIFFRACTION 0.285 0.228 True True unknown unknown unknown None None None None None 7r6x H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/23/21 SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2E12 Fab, S309 Fab, and S304 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 2.95 X-RAY DIFFRACTION 0.262 0.232 False True IGHV3 IGKV1 Kappa None None None None None 6srv H L 0 NA NA NA NA PROTEIN BINDING 09/06/19 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021144 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 2.4 X-RAY DIFFRACTION 0.241 0.205 False False IGHV3 IGLV1 Lambda None None None None None 5kw9 H L 0 A protein capsid protein vp1 ANTIVIRAL PROTEIN 07/15/16 Structural Basis for Norovirus Neutralization by a HBGA Blocking Human IgA Antibody NORWALK VIRUS; HOMO SAPIENS homo sapiens homo sapiens norwalk virus Shanker, S., Prasad, B.V.V. 2.3 X-RAY DIFFRACTION 0.212 0.186 False False IGHV1 IGKV4 Kappa 2.05e-08 -10.488644352985895 BLI TBD 4odx A L 0 Y protein 4e10 epitope scaffold t117 IMMUNE SYSTEM 01/10/14 4E10 germline encoded precursor no.7 in complex with epitope scaffold T117 HOMO SAPIENS; ARTIFICIAL GENE homo sapiens homo sapiens artificial gene Finton, K.A.K. 3.1 X-RAY DIFFRACTION 0.304 0.280 False True IGHV1 IGKV3 Kappa 2.0600000000000003e-09 -11.850005304444045 SPR TBD 3inu M N 0 IMMUNE SYSTEM 08/12/09 Crystal structure of an unbound KZ52 neutralizing anti-Ebolavirus antibody. HOMO SAPIENS homo sapiens homo sapiens Lee, J.E., Fusco, M.L., Abelson, D.M., Hessell, A.J., Burton, D.R., Saphire, E.O. 2.5 X-RAY DIFFRACTION 0.252 0.203 False True IGHV3 IGKV4 Kappa None None None None None 1b0w NA B 0 IMMUNE SYSTEM 11/13/98 Structural comparison of amyloidogenic light chain dimer in two crystal forms with nonamyloidogenic counterparts HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 1.8 X-RAY DIFFRACTION 0.299 0.226 False True IGKV1 Kappa None None None None None 3vg9 C B 0 A protein adenosine receptor a2a SIGNALING PROTEIN 08/04/11 Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T. 2.7 X-RAY DIFFRACTION 0.246 0.206 False False IGHV1 IGKV12 Kappa 4.4000000000000005e-09 -11.400370293980798 SPR TBD 6fe4 H NA 0 C protein shiga-like toxin 2 subunit b TOXIN 12/29/17 Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113 ENTEROBACTERIA PHAGE 933W; VICUGNA PACOS vicugna pacos enterobacteria phage 933w Bernedo, R., Muyldermans, S., Sterckx, Y.G.J. 3.0 X-RAY DIFFRACTION 0.207 0.169 False True IGHV3 9.6e-09 -10.938139080820335 SPR TBD 5sx5 J K 0 M protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 08/09/16 Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sickmier, E.A. 2.5 X-RAY DIFFRACTION 0.250 0.226 False True IGHV4 IGKV1 Kappa 1.15e-09 -12.195390134749905 SPR TBD 4nhc H L 0 P peptide modified fragment of hiv glycoprotein (gp41) IMMUNE SYSTEM 11/04/13 Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Irimia, A., Wilson, I.A. 2.912 X-RAY DIFFRACTION 0.268 0.210 False True IGHV1 IGKV3 Kappa None None None None None 5u4r H L 0 IMMUNE SYSTEM 12/05/16 Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 53-1A09 Fab. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Andrews, S.F., Mascola, J.R., McDermott, A.B., Kwong, P.D. 1.762 X-RAY DIFFRACTION 0.204 0.177 False True IGHV3 IGKV1 Kappa None None None None None 3w12 C D 0 E protein insulin receptor domains l1-cr HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM 11/06/12 Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7 MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Smith, B.J., Brzozowsk, A.M. 4.301 X-RAY DIFFRACTION 0.349 0.289 False True IGHV2 IGKV8 Kappa None None None None None 7wvm C D 0 F protein NA programmed cell death protein 1 IMMUNE SYSTEM/ANTITUMOR PROTEIN 02/10/22 The complex structure of PD-1 and cemiplimab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lu, D., Xu, Z.P., Liu, K.F., Tan, S.G., Gao, G.F., Chai, Y. 3.4 X-RAY DIFFRACTION 0.287 0.247 False True IGHV3 IGKV1 Kappa None None None None None 5v7u H L 0 IMMUNE SYSTEM 03/20/17 Cyrstal structure of anti-Tau antibody CBTAU-22.1 Fab HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Zhang, H., Wilson, I.A. 1.64 X-RAY DIFFRACTION 0.217 0.176 False True IGHV1 IGKV2 Kappa None None None None None 7kfw F G 0 E protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B3 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.792 X-RAY DIFFRACTION 0.229 0.189 False True IGHV3 IGKV1 Kappa None None None None None 6x96 H L 0 A protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 10A fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6i2g A NA 0 B peptide n7p-ser-arg-leu-glu-glu-glu-leu-arg-arg-arg-leu-thr-glu-lpd PEPTIDE BINDING PROTEIN 11/01/18 ALFA-tag binding nanobody (NbALFA) bound to ALFA-tag peptide. VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos synthetic construct Martinez-Carranza, M., Stenmark, P. 1.5 X-RAY DIFFRACTION 0.200 0.165 False True unknown unknown unknown None None None None None 4fqr k l 0 K protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 5t1m B A 0 IMMUNE SYSTEM 08/19/16 Cetuximab Fab in complex with CQYDLSTRRLKC MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.53 X-RAY DIFFRACTION 0.216 0.153 False True IGHV2 IGKV5 Kappa 1.5e-06 -7.945233077098003 Unknown TBD 6p3r C D 0 E protein hemagglutinin VIRAL PROTEIN 05/27/20 crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.226 0.192 False True IGHV3 IGKV1 Kappa None None None None None 6vpx P Q 0 D | C | B protein | protein | protein NA | NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp120 | envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 02/04/20 Nanodisc of full-length HIV-1 Envelope glycoprotein clone AMC011 in complex with one PGT151 Fab and three 10E8 Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Rantalainen, K., Ward, A.B.W. 5.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 4xbg E F 0 IMMUNE SYSTEM 12/16/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA): 2.73 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGKV3 Kappa None None None None None 6vpx M O 0 J | E | F peptide | protein | protein NA | NA | NA mper peptide | envelope glycoprotein gp120 | envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 02/04/20 Nanodisc of full-length HIV-1 Envelope glycoprotein clone AMC011 in complex with one PGT151 Fab and three 10E8 Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens homo sapiens | human immunodeficiency virus 1 | human immunodeficiency virus 1 Rantalainen, K., Ward, A.B.W. 5.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 4zs6 H L 0 A protein s protein IMMUNE SYSTEM 05/13/15 Receptor binding domain and Fab complex HOMO SAPIENS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Yu, X., Wang, X. 3.166 X-RAY DIFFRACTION 0.245 0.203 False True IGHV3 IGKV1 Kappa 3.12e-07 -8.875561141727196 SPR TBD 5aaw A a 0 C protein dengue serotype 4 envelope protein domain 3 07/30/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency DENGUE VIRUS; MUS MUSCULUS mus musculus dengue virus Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R. 3.27 X-RAY DIFFRACTION 0.26258 0.22661 True True unknown unknown unknown 4.320000000000001e-09 -11.411241859183763 SPR TBD 1bvk B A 0 C protein lysozyme COMPLEX (HUMANIZED ANTIBODY/HYDROLASE) 09/16/98 HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Holmes, M.A., Buss, T.N., Foote, J. 2.7 X-RAY DIFFRACTION 0.297 0.208 False True IGHV4 IGKV1 Kappa 1.40e-08 -10.53 Other 20 1560463 7l7e I J 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV1 IGKV3 Kappa None None None None None 2fec I L 0 B protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 12/15/05 Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C. 3.967 X-RAY DIFFRACTION 0.326 0.269 False True IGHV3 IGKV6D Kappa None None None None None 6fyu C NA 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/12/18 Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36 INFLUENZA A VIRUS; LAMA GLAMA lama glama influenza a virus | influenza a virus Laursen, N.S., Wilson, I.A. 2.643 X-RAY DIFFRACTION 0.216 0.186 False True IGHV1 NA NA None None None None None 3ma9 H L 0 A protein transmembrane glycoprotein IMMUNE SYSTEM 03/23/10 Crystal structure of gp41 derived protein complexed with fab 8066 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Li, M., Gustchina, E., Louis, J., Gustchina, A., Wlodawer, A., Clore, M. 2.05 X-RAY DIFFRACTION 0.245 0.193 False True IGHV1 IGLV3 Lambda 1.00e-08 -11.02 ITC 28 21085615 3ezj D NA 0 C protein general secretion pathway protein gspd PROTEIN TRANSPORT 10/22/08 Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Korotkov, K.V, Pardon, E., Steyaert, J., Hol, W.G. 2.8 X-RAY DIFFRACTION 0.239 0.192 False True IGHV1 None None None None None 3chn D N 4 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7eh3 A NA 8 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 4f33 H G 0 IMMUNE SYSTEM 05/08/12 Crystal Structure of therapeutic antibody MORAb-009 MUS MUSCULUS Xia, D., Ma, J., Tang, W.K., Esser, L. 1.749 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 IGKV4 Kappa None None None None None 7dk2 G H 0 I protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/22/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M., Chen, S. 3.0 X-RAY DIFFRACTION 0.304 0.258 False True IGHV3 IGKV1 Kappa None None None None None 7on5 A NA 0 NA NA NA NA IMMUNE SYSTEM 05/25/21 Crystal structure of the SARS-CoV-2 neutralizing nanobody Re5D06 VICUGNA PACOS vicugna pacos Aksu, M., Guttler, T., Gorlich, D. 1.25 X-RAY DIFFRACTION 0.167 0.146 False True IGHV1 NA NA None None None None None 4hlz K L 0 F | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 10/17/12 Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus | influenza a virus Dreyfus, C., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.228 False True IGHV7 IGKV12 Kappa 2e-09 -11.867518412372508 BLI TBD 7zmm E NA 0 C protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.5 X-RAY DIFFRACTION 0.281 0.240 False True IGHV1 NA NA None None None None None 6li3 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 12/10/19 cryo-EM structure of GPR52-miniGs-NB35 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens | homo sapiens Li, M., Wang, N., Xu, F., Wu, J., Lei, M. 3.32 ELECTRON MICROSCOPY False True IGHV3 None None None None None 7sfv M N 0 B protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 4jvp B NA 0 NA NA NA NA IMMUNE SYSTEM 03/26/13 Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 alpaca nanobody D03 VICUGNA PACOS vicugna pacos Krey, T., Rey, F.A. 1.76 X-RAY DIFFRACTION 0.204 0.182 False True IGHV1 NA NA None None None None None 7czz J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2F11_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7ll1 E F 0 C protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/03/21 Cryo-EM structure of BG505 DS-SOSIP in complex with glycan276-dependent broadly neutralizing antibody VRC40.01 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.73 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6gjq D NA 0 C protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/16/18 human NBD1 of CFTR in complex with nanobody T27 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.49 X-RAY DIFFRACTION 0.240 0.199 False True IGHV1 None None None None None 1qp1 NA B 0 IMMUNE SYSTEM 05/30/99 KAPPA VARIABLE LIGHT CHAIN HOMO SAPIENS homo sapiens Steinrauf, L.K. 2.06 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 6nb7 G I 0 C protein spike glycoprotein VIRUS 12/06/18 SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2) SARS CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 4.5 ELECTRON MICROSCOPY False True IGHV3 IGKV2 Kappa None None None None None 8fab D C 0 IMMUNOGLOBULIN 03/23/92 CRYSTAL STRUCTURE OF THE FAB FRAGMENT FROM THE HUMAN MYELOMA IMMUNOGLOBULIN IGG HIL AT 1.8 ANGSTROMS RESOLUTION HOMO SAPIENS homo sapiens homo sapiens Saul, F.A., Poljak, R.J. 1.8 X-RAY DIFFRACTION unknown 0.173 False False IGHV3 IGLV3 Lambda None None None None None 5tpw H L 0 A | B protein | protein NA | NA nmda glutamate receptor subunit | glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 10/21/16 Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at the GluN2A XENOPUS LAEVIS; RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus xenopus laevis | rattus norvegicus Romero-Hernandez, A., Simorowski, N., Karakas, E., Furukawa, H. 2.909 X-RAY DIFFRACTION 0.245 0.200 False False IGHV9 IGKV5 Kappa None None None None None 6s8i Y U 0 E protein enveloped glycoprotein 1 VIRAL PROTEIN 07/10/19 Structure of ZEBOV GP in complex with 3T0265 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 2.99 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6y1r C NA 0 NA NA NA NA IMMUNE SYSTEM 02/13/20 Nb22-LBT LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.85 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 NA NA None None None None None 1pkq B A 0 E protein myelin oligodendrocyte glycoprotein IMMUNE SYSTEM 06/06/03 Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Breithaupt, C., Schubart, A., Zander, H., Skerra, A., Huber, R., Linington, C., Jacob, U. 3.0 X-RAY DIFFRACTION 0.319 0.250 False True IGHV1 IGKV8 Kappa None None None None None 6be2 H L 0 IMMUNE SYSTEM 10/24/17 Crystal structure of a polysaccharide-binding human Fab (F598) HOMO SAPIENS homo sapiens homo sapiens Soliman, C., Ramsland, P.A. 1.7 X-RAY DIFFRACTION 0.210 0.171 False True IGHV4 IGLV4 Lambda None None None None None 3i02 D C 0 D carbohydrate KDA polysaccharide IMMUNE SYSTEM 06/24/09 Crystal structure of S54-10 antibody in complex with antigen Kdo(2.4)Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Muller-Loennies, S., Borisova, S.N., Brade, L., Kosma, P., Hirama, T., MacKenzie, C.R., Brade, H., Evans, S.V. 2.6 X-RAY DIFFRACTION 0.268 0.211 False False IGHV7 IGKV8 Kappa 3e-08 -10.26304286359873 Unknown TBD 3opz J N 0 C protein trans-sialidase hydrolase/immune system 09/02/10 Crystal structure of trans-sialidase in complex with the Fab fragment of a neutralizing monoclonal IgG antibody TRYPANOSOMA CRUZI; MUS MUSCULUS mus musculus mus musculus trypanosoma cruzi Larrieux, N., Muia, R., Campetella, O., Buschiazzo, A. 3.4 X-RAY DIFFRACTION 0.205 0.164 False False IGHV1 IGKV4 Kappa None None None None None 2rcs H L 0 GERMLINE ANTIBODY 05/14/97 IMMUNOGLOBULIN 48G7 GERMLINE FAB-AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY MUS MUSCULUS; HOMO SAPIENS homo sapiens mus musculus Wedemayer, G.J., Wang, L.H., Patten, P.A., Schultz, P.G., Stevens, R.C. 2.1 X-RAY DIFFRACTION 0.259 0.210 False True IGHV14 IGKV9 Kappa None None None None None 7e32 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/07/21 Serotonin 1D (5-HT1D) receptor-Gi protein complex HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI mus musculus homo sapiens | homo sapiens Xu, P., Huang, S., Zhang, H., Mao, C., Zhou, X.E., Shen, D.D., Jiang, Y., Zhang, Y., Xu, H.E. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6uta H L 0 E protein env VIRAL PROTEIN 10/29/19 Crystal structure of Z004 iGL Fab in complex with ZIKV EDIII HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Esswein, S.R., Gristick, H.B., Keeffe, J.R., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.291 0.274 False True IGHV3 IGKV1 Kappa None None None None None 7cak E D 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/08/20 SARS-CoV-2 S trimer with three RBD in the open state and complexed with three H014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 3chn D N 6 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 6zer B C 0 A protein NA rbd VIRAL PROTEIN/IMMUNE SYSTEM 06/16/20 Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 3.8 X-RAY DIFFRACTION 0.251 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6wit H L 0 I protein NA 16055 v1v2 1fd6 scaffold ANTIVIRAL PROTEIN/IMMUNE SYSTEM 04/10/20 Crystal structure of NHP D15.SD7 Fab in complex with 16055 V1V2 1FD6 scaffold MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta homo sapiens Liban, T., Aljedani, S., Rodarte, J., Pancera, M. 2.79 X-RAY DIFFRACTION 0.284 0.224 False True IGHV1 IGLV6 Lambda None None None None None 6vo0 I K 0 D protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/29/20 BG505 SOSIP.v5.2 in complex with rabbit Fab 43A2 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Nogal, B., Cottrell, C.A., Ward, A.B. 3.52 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 4k07 NA J 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 4nm8 I M 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 11/14/13 Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Lee, P.S., Wilson, I.A. 4.0041 X-RAY DIFFRACTION 0.292 0.240 False True IGHV1 IGKV4 Kappa 2.5e-09 -11.735309499921595 BLI TBD 6vy2 J N 0 E protein glycoprotein 120 IMMUNE SYSTEM 02/25/20 Cryo-EM structure of M1214_N1 Fab in complex with CH505 TF chimeric SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 4.86 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 7v61 I M 0 D protein NA angiotensin-converting enzyme 2 MEMBRANE PROTEIN 08/18/21 ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker Homo sapiens; Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 homo sapiens Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 1nbz B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 12/04/02 Crystal Structure of HyHEL-63 complexed with HEL mutant K97A MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Mariuzza, R.A., Li, Y., Urrutia, M., Smith-Gill, S.J. 1.85 X-RAY DIFFRACTION 0.229 0.229 False True IGHV3 IGKV5 Kappa 1.06e-06 SPR 25 12515535 6fn4 C B 0 A protein apo form of human-mouse chimeric abcb1 (abcb1hm) in complexwith antigen binding fragment of uic2. MEMBRANE PROTEIN 02/02/18 Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alam, A., Locher, K.P. 4.14 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6d9w H L 0 A protein divalent metal cation transporter mnth TRANSPORT PROTEIN 04/30/18 Crystal structure of Deinococcus radiodurans MntH, an Nramp-family transition metal transporter, in the inward-open apo state DEINOCOCCUS RADIODURANS; MUS MUSCULUS mus musculus mus musculus deinococcus radiodurans Gaudet, R., Bane, L.B., Weihofen, W.A., Singharoy, A., Zimanyi, C.M., Bozzi, A.T. 3.941 X-RAY DIFFRACTION 0.309 0.271 False True IGHV2 IGKV5 Kappa None None None None None 7rw2 G J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/19/21 Cryo-EM structure of NTD-directed neutralizing antibody 5-7 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7dr4 E F 0 NA NA NA NA IMMUNE SYSTEM 12/25/20 Complex of anti-human IL-2 antibody and human IL-2 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Kim, M.S., Kim, J.E. 2.49 X-RAY DIFFRACTION 0.258 0.195 False True IGHV1 IGKV17 Kappa None None None None None 1oaz H L 0 A protein thioredoxin 1 IMMUNE SYSTEM 01/21/03 IgE Fv SPE7 complexed with a recombinant thioredoxin RATTUS RATTUS; ESCHERICHIA COLI rattus rattus rattus rattus escherichia coli James, L.C., Roversi, P., Tawfik, D. 2.78 X-RAY DIFFRACTION 0.276 0.208 False True IGHV1 IGLV1 Lambda None None None None None 7e8c O Q 0 A protein NA 368-2 h VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1qp1 NA A 0 IMMUNE SYSTEM 05/30/99 KAPPA VARIABLE LIGHT CHAIN HOMO SAPIENS homo sapiens Steinrauf, L.K. 2.06 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 7p5y I NA 0 C protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5t6l A B 0 G protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 09/01/16 Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.218 0.178 False True IGHV3 IGLV3 Lambda 2.85e-11 -14.386165571647554 SPR TBD 1cz8 Y X 0 V protein vascular endothelial growth factor IMMUNE SYSTEM 09/01/99 VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B. 2.4 X-RAY DIFFRACTION 0.267 0.208 False True IGHV7 IGKV1 Kappa 1.10e-10 -14.12 SPR 37 10543973 2fjf N M 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 6orn F I 0 K protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.05 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 3cm9 D O 5 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 3c6s H G 0 H carbohydrate RAM polysaccharide IMMUNE SYSTEM 02/05/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag pentadecasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.251 0.191 False False IGHV6 IGKV2 Kappa None None None None None 3j2z H G 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m10 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 5hyq D C 0 IMMUNE SYSTEM 02/01/16 Cetuximab Fab in complex with amidated meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.477 X-RAY DIFFRACTION 0.208 0.166 False True IGHV2 IGKV5 Kappa 1.5000000000000002e-07 -9.309477166508257 Unknown TBD 7mxd J K 0 F protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/19/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Gao, F. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7r8l C D 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 RBD in complex with neutralizing antibody C099 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 2.6 X-RAY DIFFRACTION 0.229 0.180 False True IGHV5 IGKV4 Kappa None None None None None 6bfq E F 0 J protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 10/26/17 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W. 2.6 X-RAY DIFFRACTION 0.264 0.230 False True IGHV4 IGKV1 Kappa None None None None None 1fvd B A 0 IMMUNOGLOBULIN 10/20/92 X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Presta, L., Randal, M., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION unknown 0.179 False True IGHV3 IGKV1 Kappa None None None None None 3bt2 H L 0 U protein urokinase plasminogen activator surface receptor IMMUNE SYSTEM 12/27/07 Structure of urokinase receptor, urokinase and vitronectin complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Huang, M. 2.5 X-RAY DIFFRACTION 0.272 0.229 False True IGHV1 IGKV4 Kappa None None None None None 1rzj H L 0 G protein envelope glycoprotein gp120 Viral protein/Immune system 12/24/03 HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.323 0.262 False True IGHV1 IGKV3 Kappa None None None None None 2kh2 B b 19 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6a67 H L 0 A protein hemagglutinin IMMUNE SYSTEM 06/26/18 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody FLD21.140 HOMO SAPIENS; INFLUENZA A VIRUS (A/THAILAND/1(KAN-1)/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/thailand/1(kan-1)/2004(h5n1)) Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X. 2.33 X-RAY DIFFRACTION 0.235 0.197 False True IGHV4 IGLV1 Lambda 1.004e-09 -12.275831597239875 SPR TBD 1fn4 B A 0 IMMUNE SYSTEM 08/21/00 CRYSTAL STRUCTURE OF FAB198, AN EFFICIENT PROTECTOR OF ACETYLCHOLINE RECEPTOR AGAINST MYASTHENOGENIC ANTIBODIES RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Poulas, K., Eliopoulos, E., Vatzaki, E., Navaza, J., Kontou, M. 2.8 X-RAY DIFFRACTION 0.294 0.198 False False IGHV2 IGKV22 Kappa None None None None None 5dq9 H L 0 H carbohydrate KD2 2-(acetylamino)-6-O-[2-(acetylamino)-2-deoxy-4-O-phosphono-beta-D-glucopyranosyl]-2-deoxy-1-O-phosphono-alpha-D-glucopyranose IMMUNE SYSTEM 09/14/15 Structure of S55-3 Fab in complex with Lipid A MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.245 0.212 False False IGHV5 IGKV3 Kappa None None None None None 6j9o H L 0 ANTIVIRAL PROTEIN 01/23/19 Crystal structure of a free scFv molecule from a group 2 influenza A viruses HA binding antibody AF4H1K1 HOMO SAPIENS homo sapiens homo sapiens Xiao, H.X., Qi, J.X., Gao, F.G. 1.397 X-RAY DIFFRACTION 0.192 0.176 True True IGHV3 IGKV3 Kappa None None None None None 5vh4 H L 0 IMMUNE SYSTEM 04/12/17 Crystal structure of Fab fragment of anti-TNFa antibody infliximab in an I-centered orthorhombic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Mayclin, S.J., Edwards, T.E., Lerch, T.F., Conlan, H., Sharpe, P. 2.0 X-RAY DIFFRACTION 0.187 0.158 False True IGHV6 IGKV5 Kappa None None None None None 7dty N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 01/06/21 Structural basis of ligand selectivity conferred by the human glucose-dependent insulinotropic polypeptide receptor HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus | bos taurus Zhao, F.H., Zhang, C., Zhou, Q.T., Hang, K.N., Zou, X.Y., Chen, Y., Wu, F., Rao, Q.D., Dai, A.T., Yin, W.C., Shen, D.D., Zhang, Y., Xia, T., Stevens, R.C., Xu, H.E., Yang, D.H., Zhao, L.H., Wang, M.W. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6iyn A NA 0 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 6omm E e 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/19/19 Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Zhuang, Y., Liu, H., de Waal, P.W., Zhou, X.E., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Xu, H.E., Zhang, C. 3.17 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 7m7w H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/29/21 Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 2.65 X-RAY DIFFRACTION 0.271 0.221 False True IGHV1 IGLV1 Lambda None None None None None 3lrs H L 0 L carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/11/10 Structure of PG16, an antibody with broad and potent neutralization of HIV-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pancera, M., Kwong, P.D. 2.37 X-RAY DIFFRACTION 0.260 0.211 False True IGHV3 IGLV2 Lambda None None None None None 1a6u H L 0 IMMUNOGLOBULIN 03/03/98 B1-8 FV FRAGMENT MUS MUSCULUS mus musculus mus musculus Simon, T., Henrick, K., Hirshberg, M., Winter, G. 2.1 X-RAY DIFFRACTION unknown 0.192 False False IGHV1 IGLV1 Lambda None None None None None 2kqn NA B 13 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6dca H L 0 P peptide microtubule-associated protein tau IMMUNE SYSTEM 05/04/18 Fab/epitope complex of mouse monoclonal antibody 6B2 targeting a non-phosphorylated tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 2.599 X-RAY DIFFRACTION 0.259 0.189 False False IGHV1 IGKV1 Kappa None None None None None 6do1 F NA 0 B protein type-1 angiotensin ii receptor,soluble cytochrome b562 brilfusion protein MEMBRANE PROTEIN 06/08/18 Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8 HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT synthetic construct homo sapiens, escherichia coli Wingler, L.M., McMahon, C., Staus, D.P., Lefkowitz, R.J., Kruse, A.C. 2.901 X-RAY DIFFRACTION 0.359 0.305 False True IGHV1 None None None None None 6ozc O Q 0 E carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN 05/20/20 BG505 SOSIP.664 with 2G12 Fab2 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.79 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 1igc H L 0 COMPLEX (ANTIBODY/BINDING PROTEIN) 08/05/94 IGG1 FAB FRAGMENT (MOPC21) COMPLEX WITH DOMAIN III OF PROTEIN G FROM STREPTOCOCCUS MUS MUSCULUS; STREPTOCOCCUS SP. G148 mus musculus mus musculus Derrick, J.P., Wigley, D.B. 2.6 X-RAY DIFFRACTION unknown unknown False True IGHV5 IGKV6 Kappa None None None None None 3qpq H L 0 IMMUNE SYSTEM 02/14/11 Crystal structure of ANTI-TLR3 antibody C1068 FAB HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Luo, J., Obmolova, G., Teplyakov, A., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.256 0.201 False True IGHV1 IGKV12 Kappa None None None None None 4kuc H D 0 A protein ricin HYDROLASE/IMMUNE SYSTEM 05/21/13 Crystal structure of ricin-A chain in complex with the antibody 6C2 RICINUS COMMUNIS; MUS MUSCULUS mus musculus mus musculus ricinus communis Zhu, Y., Li, X., Teng, M. 2.787 X-RAY DIFFRACTION 0.289 0.238 False True IGHV1 IGKV3 Kappa None None None None None 6xq0 E F 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S8V2-18 in complex with the influenza hemagglutinin head domain of A/California/7/2009(NYMC-X181)(H1N1) INFLUENZA A VIRUS (A/REASSORTANT/NYMC X-181A(A/NYMC X-157 X CALIFORNIA/07/2009)(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/reassortant/nymc x-181a(a/nymc x-157 x california/07/2009)(h1n1)) McCarthy, K.R., Harrison, S.C. 2.3 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGKV3 Kappa None None None None None 6mb3 D O 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7tyn N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/13/22 Calcitonin Receptor in complex with Gs and salmon calcitonin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6lfm S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/03/19 Cryo-EM structure of a class A GPCR HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Liu, K.W., Wu, L.J. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6i8s H L 0 D protein plasminogen activator inhibitor 1 BLOOD CLOTTING 11/21/18 Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens Vousden, K.A., Lundqvist, T., Popovic, B. 2.9 X-RAY DIFFRACTION 0.243 0.219 False True IGHV1 IGKV1 Kappa None None None None None 3esv G g 0 IMMUNE SYSTEM 10/06/08 Crystal structure of the engineered neutralizing antibody M18 MUS MUSCULUS mus musculus Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D. 2.0 X-RAY DIFFRACTION 0.229 0.194 True True unknown unknown unknown None None None None None 7si2 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/12/21 Crystal structure of neutralizing antibody 10-28 in complex with SARS-CoV-2 spike receptor binding domain (RBD) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.2 X-RAY DIFFRACTION 0.261 0.198 False True IGHV3 IGKV1 Kappa None None None None None 7ezv M N 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/02/21 local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-812 Fab and BD-836 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, P.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5e7f C NA 0 I protein major structural protein 1 VIRAL PROTEIN 10/12/15 Complex between lactococcal phage Tuc2009 RBP head domain and a nanobody (L06) CAMELUS DROMEDARIUS; LACTOCOCCUS PHAGE TUC2009 camelus dromedarius lactococcus phage tuc2009 Legrand, P., Collins, B., Blangy, S., Murphy, J., Spinelli, S., Gutierrez, C., Richet, N., Kellenberger, C., Desmyter, A., Mahony, J., van Sinderen, D., Cambillau, C. 2.7 X-RAY DIFFRACTION 0.208 0.194 False True IGHV1 9.1e-09 -10.969830253718456 SPR TBD 5bop C NA 0 D protein octarellin v.1 DE NOVO PROTEIN 05/27/15 Crystal structure of the artificial nanobody octarellinV.1 complex SYNTHETIC CONSTRUCT; LAMA GLAMA lama glama synthetic construct Figueroa, M., Sleutel, M., Pardon, E., Steyaert, J., Martial, J.A., van de Weerdt, C. 1.95 X-RAY DIFFRACTION 0.229 0.192 False True IGHV1 None None None None None 6i04 C D 0 B protein hepatocyte growth factor receptor IMMUNE SYSTEM 10/25/18 Crystal structure of Sema domain of the Met receptor in complex with FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Casaletto, J.B., Geddie, M.L., Abu-Yousif, A.O., Masson, K., Fulgham, A., Boudot, A., Maiwald, T., Kearns, J.D., Kohli, N., Su, S., Razlog, M., Raue, A., Kalra, A., Hakansson, M., Logan, D.T., Welin, M., Chattopadhyay, S., Harms, B.D., Nielsen, U.B., Schoeberl, B., Lugovskoy, A.A., MacBeath, G. 3.1 X-RAY DIFFRACTION 0.261 0.202 False True IGHV4 IGKV1 Kappa None None None None None 5w9i K L 0 I protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7sbf E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/24/21 PZM21 bound Mu Opioid Receptor-Gi Protein Complex HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI mus musculus homo sapiens | homo sapiens Huang, W., Qu, Q., Wang, H., Skiniotis, G., Kobilka, B. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7cwt G F 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike protein in complex with hb27 and fc05 Fab cocktail SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cui, Z., Wang, X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 2kh2 B b 47 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7t0i F E 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-39 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.1 X-RAY DIFFRACTION 0.225 0.180 False True IGHV7 IGKV8 Kappa None None None None None 5xhf D C 0 NA NA NA NA IMMUNE SYSTEM 04/20/17 Crystal structure of Trastuzumab Fab fragment bearing p-azido-L-phenylalanine MUS MUSCULUS mus musculus mus musculus Kuratani, M., Yanagisawa, T., Sakamoto, K., Yokoyama, S. 3.205 X-RAY DIFFRACTION 0.297 0.219 False True IGHV3 IGKV1 Kappa None None None None None 4od3 H L 0 IMMUNE SYSTEM 01/09/14 Crystal structure of human Fab CAP256-VRC26.07, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 2.616 X-RAY DIFFRACTION 0.245 0.221 False True IGHV3 IGLV1 Lambda None None None None None 7e39 C B 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/21 SARS-CoV-2 spike in complex with the Ab4 neutralizing antibody (State 3) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, C. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6weq E F 0 A protein NA non-structural protein 1 VIRAL PROTEIN 04/02/20 DENV1 NS1 in complex with neutralizing 2B7 Fab fragment DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Akey, D.L., Smith, J.L. 3.2 X-RAY DIFFRACTION 0.261 0.207 False False IGHV1 IGKV3 Kappa None None None None None 7nx3 E D 0 A protein NA alk tyrosine kinase receptor PROTEIN BINDING 03/17/21 Crystal structure of ALK in complex with Fab324 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens De Munck, S., Savvides, S.N. 2.81 X-RAY DIFFRACTION 0.266 0.228 False True IGHV1 IGKV3 Kappa None None None None None 4ocm F NA 0 E | D protein | protein NA | NA 26s proteasome regulatory subunit rpn11 | 26s proteasome regulatory subunit rpn8 HYDROLASE, PROTEIN BINDING 01/09/14 Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form Ib SACCHAROMYCES CEREVISIAE; LAMA GLAMA lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Pathare, G.R., Bracher, A. 1.99 X-RAY DIFFRACTION 0.262 0.216 False True IGHV1 NA NA None None None None None 6gk8 H L 0 I peptide tau peptide a7731 (residues 52-71) IMMUNE SYSTEM 05/18/18 Crystal structure of anti-tau antibody dmCBTAU-28.1, double mutant (S32R, E35K) of CBTAU-28.1, in complex with Tau peptide A7731 (residues 52-71) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Steinbacher, S., Mrosek, M., Juraszek, J. 2.85 X-RAY DIFFRACTION 0.278 0.236 False True IGHV5 IGKV4 Kappa None None None None None 7e5r O E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 2mkw NA A 14 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6ss5 H L 0 NA NA NA NA PROTEIN BINDING 09/06/19 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0020187 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 1.78 X-RAY DIFFRACTION 0.217 0.178 False False IGHV3 IGLV1 Lambda None None None None None 6idk M N 0 F protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 5.0 (Class I particle) DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 25 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 5ff6 D C 0 IMMUNE SYSTEM 12/17/15 Cetuximab Fab in complex with L10Q meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.5 X-RAY DIFFRACTION 0.201 0.155 False True IGHV2 IGKV5 Kappa 9.499999999999999e-06 -6.851610886869331 Unknown TBD 2vxu I M 0 IMMUNE SYSTEM 07/10/08 Crystal structure of murine reference antibody 125-2H Fab fragment MUS MUSCULUS mus musculus mus musculus Argiriadi, M.A., Xiang, T., Wu, C., Ghayur, T., Borhani, D.W. 2.36 X-RAY DIFFRACTION 0.242 0.184 False True IGHV1 IGKV9 Kappa None None None None None 7evy E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Jia, G.W., Yuan, Y., Su, Z.M., Shao, Z.H. 2.98 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 32c2 B A 0 IMMUNE SYSTEM 04/21/99 STRUCTURE OF AN ACTIVITY SUPPRESSING FAB FRAGMENT TO CYTOCHROME P450 AROMATASE MUS MUSCULUS mus musculus mus musculus Sawicki, M.W., Ng, P.C., Burkhart, B., Pletnev, V., Higashiyama, T., Osawa, Y., Ghosh, D. 3.0 X-RAY DIFFRACTION 0.317 0.213 False False IGHV3 IGKV3 Kappa None None None None None 5j1s C NA 0 A | B protein | protein NA | NA torsin-1a | torsin-1a-interacting protein 2 HYDROLASE 03/29/16 TorsinA-LULL1 complex, H. sapiens, bound to VHH-BS2 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens | homo sapiens Demircioglu, F.E., Schwartz, T.U. 1.399 X-RAY DIFFRACTION 0.188 0.143 False True IGHV1 None None None None None 6jri C NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 2mmx NA A 5 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 7dun H L 0 NA NA NA NA ANTITUMOR PROTEIN 01/10/21 Crystal structure of Fab fragment of Daratumumab HOMO SAPIENS homo sapiens homo sapiens Yu, X.J., Wang, L., Yu, C.F. 1.607 X-RAY DIFFRACTION 0.218 0.205 False True IGHV3 IGKV3 Kappa None None None None None 6n1v 1 2 0 E protein envelope glycoprotein gp41 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False True IGHV4 IGLV1 Lambda None None None None None 7o3b A NA 0 G protein NA tau-tubulin kinase 2,centrosomal protein of 164 kda STRUCTURAL PROTEIN 04/01/21 Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody CAMELIDAE MIXED LIBRARY; HOMO SAPIENS camelidae mixed library homo sapiens e Silva, I.R., van Breugel, M. 2.4 X-RAY DIFFRACTION 0.240 0.189 False True IGHV1 NA NA None None None None None 6wo5 G I 0 F protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/24/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody 212.1.1 and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 2.619 X-RAY DIFFRACTION 0.250 0.203 False True IGHV1 IGKV1 Kappa None None None None None 5dmg E F 0 X peptide microtubule-associated protein IMMUNE SYSTEM 09/08/15 X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430) ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Benz, J., Lorenz, S., Georges, G., Jochner, A., Goepfert, U., Grueninger, F., Bujotzek, A. 2.5 X-RAY DIFFRACTION 0.263 0.210 False True IGHV1 IGKV1 Kappa None None None None None 2mmx NA A 11 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 5ysl E F 0 IMMUNE SYSTEM 11/14/17 Crystal structure of antibody 1H1 Fab MUS MUSCULUS mus musculus mus musculus Hu, X.L., Yang, F.L. 2.5 X-RAY DIFFRACTION 0.273 0.212 False True IGHV1 IGKV4 Kappa None None None None None 6qnk B A 0 IMMUNE SYSTEM 02/11/19 Antibody FAB fragment targeting Gi protein heterotrimer MUS MUSCULUS mus musculus mus musculus Tsai, C.-J., Muehle, J., Pamula, F., Dawson, R.J.P., Maeda, S., Deupi, X., Schertler, G.F.X. 1.9 X-RAY DIFFRACTION 0.212 0.180 False True IGHV5 IGKV2 Kappa None None None None None 5td8 E NA 0 C | A protein | protein NA | NA kinetochore protein spc24 | kinetochore protein ndc80 REPLICATION 09/17/16 Crystal structure of an Extended Dwarf Ndc80 Complex SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) Valverde, R., Ingram, J., Harrison, S.C. 7.531 X-RAY DIFFRACTION 0.328 0.312 False True IGHV1 None None None None None 4k07 NA C 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 7lfa B D 0 A protein NA apolipoprotein l1 IMMUNE SYSTEM 01/15/21 Fab 3B6 bound to ApoL1 NTD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Kirchhofer, D. 1.857 X-RAY DIFFRACTION 0.242 0.205 False True IGHV1 IGLV1 Lambda None None None None None 7ul3 H L 0 NA NA NA NA MEMBRANE PROTEIN 04/03/22 CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab Homo sapiens; synthetic construct synthetic construct synthetic construct Robertson, M.J., Skiniotis, G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7rdw U V 0 D protein NA glycoprotein 120 IMMUNE SYSTEM 07/12/21 Crystal Structure of FH1 Fab bound to HXb2 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Weidle, C., Pancera, M. 3.55 X-RAY DIFFRACTION 0.295 0.260 False True IGHV1 IGKV3 Kappa None None None None None 4r26 H L 0 Immune System 08/08/14 Crystal structure of human Fab PGT124, a broadly neutralizing and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Garces, F., Kong, L., Wilson, I.A. 2.4969 X-RAY DIFFRACTION 0.267 0.233 False True IGHV4 IGLV3 Lambda None None None None None 2fjf K J 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 1q9l B A 0 IMMUNE SYSTEM 08/25/03 S25-2 Fab Unliganded 2 MUS MUSCULUS mus musculus mus musculus Nguyen, H.P., Seto, N.O., MacKenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 2.28 X-RAY DIFFRACTION 0.286 0.216 False False IGHV7 IGKV8 Kappa None None None None None 7rkv G L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C118 (State 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Jette, C.A., Bjorkman, P.J. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 7c2l J N 0 C protein NA spike glycoprotein MEMBRANE PROTEIN/IMMUNE SYSTEM 05/08/20 S protein of SARS-CoV-2 in complex bound with 4A8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Guo, Y.Y., Li, Y.N., Xia, L., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 1kxq H NA 0 A protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 1.6 X-RAY DIFFRACTION 0.219 0.197 False True IGHV1 3.50e-09 -11.53 SPR 11960990 6xm2 D C 0 J protein NA transforming growth factor beta-2 CYTOKINE/IMMUNE SYSTEM 06/29/20 The structure of the 4A11.v7 antibody in complex with human TGFb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lupardus, P.J., Yin, J.P. 1.91 X-RAY DIFFRACTION 0.244 0.205 False True IGHV4 IGKV3 Kappa None None None None None 3b5g NA B 0 IMMUNE SYSTEM 10/25/07 Crystal Structure of the Unstable and Highly Fibrillogenic PRO7SER Mutant of the Recombinant Variable Domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A. 1.9 X-RAY DIFFRACTION 0.210 0.164 False True IGLV6 Lambda None None None None None 5lhn B NA 0 A protein urokinase-type plasminogen activator Hydrolase/Antibody 07/12/16 The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 MUS MUSCULUS; VICUGNA PACOS vicugna pacos mus musculus Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P., Andreasen, P.A. 2.55 X-RAY DIFFRACTION 0.219 0.177 False True IGHV1 1.12e-08 -10.84680731876178 SPR TBD 7lzp B NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/10/21 LC/A-JPU-B9-JPU-A11-JPU-G11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.86 X-RAY DIFFRACTION 0.273 0.235 False True IGHV1 NA NA None None None None None 4d9l I M 0 IMMUNE SYSTEM 01/11/12 Fab structure of anti-HIV-1 gp120 V2 mAb 697 HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.485 X-RAY DIFFRACTION 0.238 0.176 False True IGHV1 IGLV1 Lambda None None None None None 6app A NA 0 B protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody A Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS (STRAIN MUSOKE-80) lama glama lake victoria marburgvirus (strain musoke-80) Taylor, A.B., Garza, J.A. 1.75 X-RAY DIFFRACTION 0.219 0.172 False True unknown unknown unknown None None None None None 7mw4 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7mfu E NA 0 D protein NA spike protein s1 VIRAL PROTEIN 04/11/21 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 1.7 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 NA NA None None None None None 7lop W V 0 Z protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/10/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.246 X-RAY DIFFRACTION 0.268 0.220 False True IGHV5 IGKV4 Kappa None None None None None 5wuv H L 0 IMMUNE SYSTEM 12/21/16 Crystal structure of Certolizumab Fab HOMO SAPIENS homo sapiens homo sapiens Heo, Y.S., Lee, J.U., Son, J.Y., Shin, W., Yoo, K.Y. 1.952 X-RAY DIFFRACTION 0.179 0.148 False True IGHV3 IGKV1 Kappa None None None None None 2op4 H L 0 IMMUNE SYSTEM 01/26/07 Crystal Structure of Quorum-Quenching Antibody 1G9 MUS MUSCULUS mus musculus mus musculus Kirchdoerfer, R.N., Debler, E.W., Wilson, I.A. 2.85 X-RAY DIFFRACTION 0.263 0.200 False False IGHV1 IGLV1 Lambda None None None None None 6mft A B 0 C protein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 09/12/18 Crystal structure of glycosylated 426c HIV-1 gp120 core G459C in complex with glVRC01 A60C heavy chain HOMO SAPIENS homo sapiens homo sapiens homo sapiens Weidle, C., Pancera, M., Stamatatos, L., Gray, M. 2.315 X-RAY DIFFRACTION 0.295 0.244 False True IGHV1 IGKV3 Kappa 2.2999999999999996e-06 -7.691979474199363 SPR TBD 4olx H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07-G54L in complex with clade A/E 93TH057 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.247 0.201 False True unknown IGKV3 Kappa None None None None None 7piv N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/23/21 Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution. HOMO SAPIENS; RATTUS NORVEGICUS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus norvegicus Heyder, N.A., Schmidt, A., Kleinau, G., Hilal, T., Scheerer, P. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2ltq F E 2 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 5wnb H L 0 B peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 07/31/17 Structure of antibody 3D3 bound to the linear epitope of RSV G HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human respiratory syncytial virus a Fedechkin, S.O., George, N.L., Wolff, J.T., Kauvar, L.M., DuBois, R.M. 2.4 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV3 Kappa None None None None None 7jwp C D 0 R peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 1uj3 B A 0 C protein tissue factor IMMUNE SYSTEM/BLOOD CLOTTING 07/25/03 Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ohto, U., Mizutani, R., Nakamura, M., Adachi, H., Satow, Y. 2.1 X-RAY DIFFRACTION 0.227 0.196 False True IGHV1 IGKV1D Kappa None None None None None 3chn B M 5 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7lr4 A B 0 C protein NA hapless 2 CELL ADHESION/IMMUNE SYSTEM 02/15/21 Complex of Fab 2/1.12 with domain 3 of P. berghei HAP2 MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Feng, J., Dong, X.C., Su, Y., Lu, X.F., Springer, T.A. 2.1 X-RAY DIFFRACTION 0.231 0.189 False True IGHV1 IGKV10 Kappa None None None None None 5nml A NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 6i8s E I 0 A protein plasminogen activator inhibitor 1 BLOOD CLOTTING 11/21/18 Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens Vousden, K.A., Lundqvist, T., Popovic, B. 2.9 X-RAY DIFFRACTION 0.243 0.219 False True IGHV1 IGKV1 Kappa None None None None None 6aod B A 0 C protein coagulation factor xi BLOOD CLOTTING/IMMUNE SYSTEM 08/15/17 FXIa antibody complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lolicato, M., Minor, D.L. 1.8 X-RAY DIFFRACTION 0.207 0.182 False True IGHV1 IGKV1 Kappa 1.62e-10 -13.356611273870055 SPR TBD 7m6h D F 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, BG7-20 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5yhl H L 0 A protein prostaglandin e2 receptor ep4 subtype SIGNALING PROTEIN/IMMUNE SYSTEM 09/28/17 Crystal structure of the clinically important GPCR in complex with functional antibody. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T. 4.2 X-RAY DIFFRACTION 0.359 0.333 False True IGHV1 IGKV14 Kappa 1.8000000000000002e-08 -10.565698709005899 Unknown TBD 7chs H L 0 E protein NA spike protein s1 VIRAL PROTEIN 07/06/20 Crystal structure of SARS-CoV-2 antibody P22A-1D1 with RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J., Wang, R., Zhang, Q. 2.401 X-RAY DIFFRACTION 0.224 0.191 False True IGHV3 IGKV1 Kappa None None None None None 1a3l H L 0 L Hapten CFC 1-CARBOXY-1'-[(DIMETHYLAMINO)-CARBONYL]FERROCENE IMMUNOGLOBULIN 01/22/98 CATALYSIS OF A DISFAVORED REACTION: AN ANTIBODY EXO DIELS-ALDERASE-TSA-INHIBITOR COMPLEX AT 1.95 A RESOLUTION MUS MUSCULUS mus musculus mus musculus mus musculus Heine, A., Wilson, I.A. 1.95 X-RAY DIFFRACTION unknown unknown False False IGHV1 IGKV2 Kappa None None None None None 5tzt A B 0 D protein leukocyte surface antigen cd47 IMMUNE SYSTEM 11/22/16 Crystal structure of human CD47 ECD bound to Fab of C47B161 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cardoso, R.M.F. 2.89 X-RAY DIFFRACTION 0.328 0.257 False True IGHV1 IGKV1 Kappa 2.8700000000000002e-09 -11.653534133424982 SPR TBD 3eak A NA 0 IMMUNE SYSTEM 08/26/08 NbBCII10 humanized (FGLA mutant) CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., Conrath, K. 1.95 X-RAY DIFFRACTION 0.252 0.215 False True IGHV1 None None None None None 6cm3 R S 0 A protein envelope glycoprotein gp160 VIRAL PROTEIN 03/02/18 BG505 SOSIP in complex with sCD4, 17b, 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 3.54 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 4xak D E 0 B protein spike glycoprotein IMMUNE SYSTEM 12/15/14 Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD HUMAN CORONAVIRUS EMC; HOMO SAPIENS homo sapiens homo sapiens human coronavirus emc Zhou, T., Dimtrov, D.S., Ying, T. 2.45 X-RAY DIFFRACTION 0.249 0.198 False True IGHV1 IGKV1 Kappa None None None None None 3p11 H L 0 A protein receptor tyrosine-protein kinase erbb-3 IMMUNE SYSTEM 09/29/10 anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Shia, S. 3.7 X-RAY DIFFRACTION 0.323 0.245 False True IGHV3 IGKV1 Kappa 2.55e-09 -12.19 SPR 37 22014573 6p3s I J 0 K protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 6uft B NA 0 A protein botulinum neurotoxin type b TOXIN/ANTITOXIN 09/25/19 Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.90008 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 None None None None None 4yqx N O 0 M protein NA interleukin-2 CYTOKINE/IMMUNE SYSTEM 03/13/15 Mouse IL-2 Bound to JES6-1 scFv Fragment RATTUS NORVEGICUS; MUS MUSCULUS rattus norvegicus rattus norvegicus mus musculus Spangler, J.B., Luca, V.C., Jude, K.M., Garcia, K.C. 2.826 X-RAY DIFFRACTION 0.204 0.170 False True IGHV1 IGKV8 Kappa None None None None None 6tko H L 0 B | A protein | protein NA | NA beta-arrestin-1 | beta-1 adrenergic receptor SIGNALING PROTEIN 06/17/20 Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc. MELEAGRIS GALLOPAVO; HOMO SAPIENS; PHAGE DISPLAY VECTOR PTDISP phage display vector ptdisp phage display vector ptdisp homo sapiens | meleagris gallopavo Lee, Y., Tate, C.G. 3.3 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6was H L 0 J protein NA 1fd6 16055 v1v2 scaffold IMMUNE SYSTEM 03/26/20 Structure of D19.PA8 Fab in complex with 1FD6 16055 V1V2 scaffold HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Singh, S., Liban, T.J., Pancera, M. 1.904 X-RAY DIFFRACTION 0.228 0.194 False True IGHV3 IGLV6 Lambda None None None None None 6h7n C NA 0 A protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G. 2.5 X-RAY DIFFRACTION 0.266 0.248 False True IGHV1 3.5000000000000003e-09 -11.535955190950428 Unknown TBD 5vnv A NA 0 DE NOVO PROTEIN 05/01/17 Crystal structure of Nb.b201 SYNTHETIC CONSTRUCT synthetic construct Kruse, A.C., McMahon, C. 1.4 X-RAY DIFFRACTION 0.214 0.183 False True IGHV1 None None None None None 2kh2 B b 28 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7dfc H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | v2rpp-3 SIGNALING PROTEIN 11/06/20 Crystal of Arrestin2-V2Rpp-3-Fab30 complex BOS TAURUS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | synthetic construct Sun, J.P., Yu, X., Xiao, P., He, Q.T., Lin, J.Y., Zhu, Z.L. 2.49 X-RAY DIFFRACTION 0.284 0.229 False True IGHV3 IGKV1 Kappa None None None None None 4jn2 B A 0 A Hapten C24 3-({2-[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-3-METHYL-3H-BENZOIMIDAZOLE-5-CARBONYL}-PYRIDIN-2-YL-AMINO)-PROPIONIC ACID ETHYL ESTER immune system/inhibitor 03/14/13 An Antidote for Dabigatran MUS MUSCULUS mus musculus mus musculus mus musculus Schiele, F., Nar, H. 1.71 X-RAY DIFFRACTION 0.182 0.167 False True IGHV4 IGKV2 Kappa 2.1e-12 -15.931343304588362 Unknown TBD 6mqm A B 0 C peptide hiv env fusion peptide residue 512-519 IMMUNE SYSTEM 10/10/18 Vaccine-elicited NHP FP-targeting neutralizing antibody DF1W-a.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 3.484 X-RAY DIFFRACTION 0.246 0.200 False True IGHV4 IGKV2 Kappa None None None None None 7epx I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/28/21 S protein of SARS-CoV-2 in complex with GW01 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shen, Y.P., Zhang, Y.Y., Yan, R.H., Li, Y.N., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 6fla H L 0 I protein domain iii of dengue virus 2 VIRAL PROTEIN 01/25/18 3H5 Fab bound to EDIII of DenV 2 Xtal form 1 MUS MUSCULUS; DENGUE VIRUS 2 mus musculus mus musculus dengue virus 2 Flanagan, A., Renner, M., Grimes, J.M. 2.9 X-RAY DIFFRACTION 0.221 0.203 False True IGHV1 IGKV3 Kappa None None None None None 3hnt H L 0 H carbohydrate AXR polysaccharide IMMUNE SYSTEM 06/01/09 CS-35 Fab complex with a linear, terminal oligoarabinofuranosyl tetrasaccharide from lipoarabinomannan MUS MUSCULUS mus musculus mus musculus mus musculus Murase, T., Zheng, R.B., Joe, M., Bai, Y., Marcus, S.L., Lowary, T.L., Ng, K.K.S. 1.8 X-RAY DIFFRACTION 0.255 0.196 False False IGHV1 IGKV10 Kappa None None None None None 3ujt I M 0 IMMUNE SYSTEM 11/08/11 Structure of the Fab fragment of Ab-52, an antibody that binds the O-antigen of Francisella tularensis MUS MUSCULUS mus musculus mus musculus Rynkiewicz, M.J., Lu, Z., Hui, J.H., Sharon, J., Seaton, B.A. 2.1 X-RAY DIFFRACTION 0.220 0.186 False False IGHV1 IGKV8 Kappa None None None None None 7crh N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 CELL CYCLE 08/13/20 Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Yan, W., Shao, Z.H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5ocl F NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA vicugna pacos Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 6bsp A B 0 D protein major capsid protein l1 VIRUS/IMMUNE SYSTEM 12/04/17 High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitope on Human Papillomavirus 16 MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 Guan, J., Bywaters, S.M., Brendle, S.A., Ashley, R.E., Makhov, A.M., Conway, J.F., Christenson, N.D., Hafenstein, S. 4.7 ELECTRON MICROSCOPY False False IGHV5 IGKV8 Kappa None None None None None 7m7i E F 0 B protein NA eryai BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2 (TE-free) SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS saccharopolyspora erythraea homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 3ixx I J 0 E | B protein | protein NA | NA peptide pr | envelope protein e VIRUS 02/26/09 The pseudo-atomic structure of West Nile immature virus in complex with Fab fragments of the anti-fusion loop antibody E53 WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus | west nile virus Cherrier, M.V., Kaufmann, B., Nybakken, G.E., Lok, S.M., Warren, J.T., Nelson, C.A., Kostyuchenko, V.A., Holdaway, H.A., Chipman, P.R., Kuhn, R.J., Diamond, M.S., Rossmann, M.G., Fremont, D.H. 15 ELECTRON MICROSCOPY False True IGHV7 IGKV4 Kappa None None None None None 6iyn A NA 18 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 4w70 A NA 0 NA NA NA NA IMMUNE SYSTEM 08/21/14 Periplasmically Produced Monomeric Single Domain Antibody (sdAb) C22A/C99V variant against Staphylococcal enterotoxin B (SEB) at pH 7.0 LAMA GLAMA lama glama George, J., Legler, P.M. 2.28 X-RAY DIFFRACTION 0.236 0.188 False True IGHV1 NA NA None None None None None 5e2t H L 0 IMMUNE SYSTEM 10/01/15 Crystal structure of anti-TAU antibody AT8 FAB MUS MUSCULUS mus musculus mus musculus Malia, T., Teplyakov, A. 2.1 X-RAY DIFFRACTION 0.246 0.207 False True IGHV3 IGKV2 Kappa None None None None None 6txz H L 0 A protein hepatitis a virus cellular receptor 2 IMMUNE SYSTEM 04/08/20 FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Musil, D., Sood, V. 3.06 X-RAY DIFFRACTION 0.253 0.197 False True IGHV3 IGLV2 Lambda None None None None None 5u3l H L 0 P peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.2 Fab in Complex with HIV-1 gp41 MPER 670-683 Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 2.165 X-RAY DIFFRACTION 0.231 0.205 False True IGHV3 IGKV1 Kappa None None None None None 5d72 M N 0 B protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 08/13/15 Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M. 2.6 X-RAY DIFFRACTION 0.266 0.232 False True IGHV3 IGLV3 Lambda 6e-12 -15.309340828919966 Unknown TBD 1za3 B A 0 S protein tumor necrosis factor receptor superfamily member 10b IMMUNE SYSTEM/SIGNALING PROTEIN 04/05/05 The crystal structure of the YSd1 Fab bound to DR5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Fellouse, F.A., Li, B., Compaan, D.M., Peden, A.A., Hymowitz, S.G., Sidhu, S.S. 3.35 X-RAY DIFFRACTION 0.280 0.224 False True IGHV3 IGKV1 Kappa 3.40e-08 -10.18 SPR 15854651 6v4o H L 0 N protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 2E01 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7n04 H L 0 NA NA NA NA IMMUNE SYSTEM 05/25/21 Crystal structure of the apo F240 antibody fragment HOMO SAPIENS homo sapiens homo sapiens Cook, J.D., Lee, J.E. 1.70001 X-RAY DIFFRACTION 0.222 0.179 False True unknown IGKV4 Kappa None None None None None 3okd B A 0 IMMUNE SYSTEM 08/24/10 Crystal structure of S25-39 in complex with Kdo MUS MUSCULUS mus musculus mus musculus Blackler, R.J., Evans, S.V. 1.8 X-RAY DIFFRACTION 0.275 0.233 False False IGHV7 IGKV8 Kappa None None None None None 2g5b F E 0 K peptide bax peptide APOPTOSIS 02/22/06 Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Peyerl, F.W., Dai, S., Murphy, G.A., Marrack, P., Kappler, J.W. 2.3 X-RAY DIFFRACTION 0.275 0.234 False True IGHV7 IGKV8 Kappa None None None None None 1mcb NA A 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS; SYNTHETIC CONSTRUCT phoca vitulina Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 4a6y H L 0 IMMUNE SYSTEM 11/10/11 CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI-(4-HYDROXY-3-NITROPHENYL) -ACETYL MURINE GERMLINE ANTIBODY BBE6.12H3 MUS MUSCULUS mus musculus mus musculus KHAN, T., SALUNKE, D.M. 2.9 X-RAY DIFFRACTION 0.26 0.24 False False IGHV1 IGLV1 Lambda None None None None None 2kh2 B b 61 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6v8z P Q 0 M protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 2.9 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 7wea H L 0 A | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with two XGv347 binding to one close state RBD and one open state RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7djy C NA 0 NA NA NA NA BIOSYNTHETIC PROTEIN 11/22/20 Clec4f Nanobody 322 LAMIUM MACULATUM lamium maculatum Wen, Y., Zheng, F. 2.7 X-RAY DIFFRACTION 0.266 0.228 False True IGHV1 NA NA None None None None None 3cm9 A L 1 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6mfj A B 0 IMMUNE SYSTEM 09/11/18 Crystal structure of the ADCC potent antibody DH677.3 Fab elicited in the RV305 vaccine trial. HOMO SAPIENS homo sapiens homo sapiens Young, B., Tolbert, W.D., Pazgier, M. 2.62 X-RAY DIFFRACTION 0.261 0.199 False True IGHV1 IGKV1 Kappa None None None None None 5mp1 J K 0 I peptide microtubule-associated protein tau IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 3.1 X-RAY DIFFRACTION 0.268 0.222 False False IGHV1 IGKV8 Kappa None None None None None 2ltq F E 7 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 1jnh F E 0 F Hapten ECO ESTRADIOL-6 CARBOXYL-METHYL-OXIME IMMUNE SYSTEM 07/24/01 Crystal Structure of Fab-Estradiol Complexes MUS MUSCULUS mus musculus mus musculus mus musculus Monnet, C., Bettsworth, F., Stura, E.A., Le Du, M.-H., Menez, R., Derrien, L., Zinn-Justin, S., Gilquin, B., Sibai, G., Battail-Poirot, N., Jolivet, M., Menez, A., Arnaud, M., Ducancel, F., Charbonnier, J.B. 2.85 X-RAY DIFFRACTION 0.253 0.198 False False IGHV1 IGLV1 Lambda None None None None None 7vnb A NA 0 B protein NA spike protein s1 VIRAL PROTEIN 10/10/21 Crystal structure of the SARS-CoV-2 RBD in complex with a human single domain antibody n3113 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens severe acute respiratory syndrome coronavirus2 Yang, Z., Wang, Y., Kong, Y., Jin, Y., Wu, Y., Ying, T. 2.27 X-RAY DIFFRACTION 0.203 0.177 False True IGHV3 NA NA None None None None None 5ik3 C D 0 IMMUNE SYSTEM 03/03/16 Crystal structure of anti-gliadin 1002-1E03 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.65 X-RAY DIFFRACTION 0.236 0.196 False True IGHV3 IGKV4 Kappa None None None None None 5dqj A B 0 IMMUNE SYSTEM 09/14/15 Structure of unliganded S55-5 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.61 X-RAY DIFFRACTION 0.228 0.193 False False IGHV5 IGKV3 Kappa None None None None None 7kbp D d 0 NA NA NA NA PROTEIN BINDING 10/02/20 Herceptin Diabody with R83T, E85C Mutations HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 2.3 X-RAY DIFFRACTION 0.232 0.184 True True unknown unknown unknown None None None None None 7nj7 F NA 0 A protein NA polymerase acidic protein VIRAL PROTEIN 02/16/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (a/brevigmission/1/1918(h1n1)) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.82 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7cac E D 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 06/08/20 SARS-CoV-2 S trimer with one RBD in the open state and complexed with one H014 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 2vq1 B A 0 IMMUNE SYSTEM 03/10/08 anti trimeric Lewis X Fab54-5C10-A MUS MUSCULUS mus musculus mus musculus de Geus, D.C., van Roon, A.M.M., Thomassen, E.A.J., Hokke, C.H., Deelder, A.M., Abrahams, J.P. 2.5 X-RAY DIFFRACTION 0.260 0.203 False False IGHV8 IGKV1 Kappa None None None None None 6k5a E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/28/19 Crystal structure of the E148D/R147A/F317A mutant in presence of 200 mM NaBr ESCHERICHIA COLI MS 117-3; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 117-3 Park, K., Lim, H.H. 3.162 X-RAY DIFFRACTION 0.276 0.222 False True IGHV4 IGKV4 Kappa None None None None None 1yei H L 0 L Hapten PGG PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINE IMMUNE SYSTEM 08/13/98 CATALYTIC ANTIBODY D2.3 COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Knossow, M. 1.9 X-RAY DIFFRACTION 0.241 0.204 False False IGHV1 IGKV1 Kappa 3.5e-08 -10.171711101540176 Unknown TBD 4at6 C D 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 7llk K L 0 I protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/21 Cryo-EM structure of Q23.17_DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody 179NC75 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 4.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 2r8s H L 0 R nucleic-acid p4-p6 rna ribozyme domain IMMUNE SYSTEM/RNA 09/11/07 High resolution structure of a specific synthetic FAB bound to P4-P6 RNA ribozyme domain MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Ye, J.D., Tereshko, V., Sidhu, S.S., Koide, S., Kossiakoff, A.A., Piccirilli, J.A. 1.95 X-RAY DIFFRACTION 0.226 0.195 False False IGHV3 IGKV1 Kappa 5.1e-08 -9.94865428469745 Unknown TBD 6mv5 H L 0 P peptide proprotein convertase subtilisin/kexin type 9 IMMUNE SYSTEM 04/10/19 Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9 (E32K) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Ultsch, M.H., Kirchhofer, D.K. 2.1 X-RAY DIFFRACTION 0.239 0.210 False True IGHV6 IGKV2 Kappa None None None None None 6edu P Q 0 F | B protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 IMMUNE SYSTEM 08/11/18 B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4.06 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 4lrn H L 0 IMMUNE SYSTEM 07/20/13 Ontogeny of recognition specificity and functionality for the anti-HIV antibody 4E10 HOMO SAPIENS homo sapiens homo sapiens Finton, K.A.K. 1.89 X-RAY DIFFRACTION 0.233 0.187 False True IGHV1 IGKV3 Kappa None None None None None 4jzo G H 0 L peptide envelope glycoprotein e2 immune system/viral protein 04/03/13 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-27 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus (isolate h) Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.236 0.196 False True IGHV1 IGLV3 Lambda None None None None None 7cdi H L 0 E protein NA spike protein s1 VIRAL PROTEIN 06/19/20 Crystal structure of SARS-CoV-2 antibody P2C-1F11 with RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J., Wang, R. 2.96 X-RAY DIFFRACTION 0.254 0.202 False True IGHV3 IGKV3 Kappa None None None None None 5ken Q P 0 K protein ebola surface glycoprotein, gp1 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76); ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV8 IGKV6 Kappa None None None None None 3dif D C 0 IMMUNE SYSTEM 06/20/08 Crystal structure of FabOX117 HOMO SAPIENS homo sapiens homo sapiens Nettleship, J.E., Ren, J., Owens, R.J., Oxford Protein Production Facility (OPPF) 2.4 X-RAY DIFFRACTION 0.286 0.219 False True IGHV1 IGKV6 Kappa None None None None None 7k3q H L 0 NA NA NA NA IMMUNE SYSTEM 09/12/20 An ultra-potent human neutralizing antibody locks the SARS-CoV-2 spike in the closed conformation HOMO SAPIENS homo sapiens homo sapiens Snell, G., Czudnochowski, N., Ng, C. 1.38 X-RAY DIFFRACTION 0.215 0.199 False True IGHV1 IGKV3 Kappa None None None None None 7bm5 K J 0 NA NA NA NA IMMUNE SYSTEM 01/19/21 Crystal structure of Fab1, the Fab fragment of the anti-BamA monoclonal antibody MAB1 HOMO SAPIENS homo sapiens homo sapiens White, P., Storek, K.M., Rutherford, S.T., Radford, S.E. 2.95 X-RAY DIFFRACTION 0.290 0.257 False True IGHV5 IGKV12 Kappa None None None None None 7kew G J 0 A protein NA spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-43 BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus Murin, C.D., Ward, A.B. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5u0r H L 0 IMMUNE SYSTEM 11/26/16 Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.295 X-RAY DIFFRACTION 0.273 0.245 False True IGHV1 IGLV2 Lambda None None None None None 1ndg B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 12/09/02 Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Mariuzza, R.A., Li, Y., Li, H., Yang, F., Smith-Gill, S.J. 1.9 X-RAY DIFFRACTION 0.249 0.206 False True IGHV3 IGKV5 Kappa None None None None None 7v0v A NA 16 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 5t80 H L 0 G protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 09/06/16 Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 and phosphatidic acid (06:0 PA) SYNTHETIC CONSTRUCT; HOMO SAPIENS homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.62 X-RAY DIFFRACTION 0.243 0.184 False True IGHV3 IGLV3 Lambda None None None None None 3esv F f 0 IMMUNE SYSTEM 10/06/08 Crystal structure of the engineered neutralizing antibody M18 MUS MUSCULUS mus musculus Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D. 2.0 X-RAY DIFFRACTION 0.229 0.194 True True unknown unknown unknown None None None None None 3qum H L 0 P protein prostate-specific antigen IMMUNE SYSTEM 02/24/11 Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Stura, E.A., Muller, B.H., Michel, S., Ducancel, F. 3.2 X-RAY DIFFRACTION 0.294 0.198 False False IGHV1 IGKV2 Kappa None None None None None 7cws L C 0 Q protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike Proteins Trimer in Complex with FC05 and H014 Fabs Cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L., Wang, X. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6dl8 H L 0 IMMUNE SYSTEM 05/31/18 Crystal Structure of an influenza A hemagglutinin antibody Fab variant CH67:1203d4 chimera HOMO SAPIENS homo sapiens homo sapiens Dong, J., Finn, J.A., Crowe, J.E. 3.805 X-RAY DIFFRACTION 0.284 0.233 False True IGHV1 IGLV3 Lambda None None None None None 4gay H L 0 IMMUNE SYSTEM 07/26/12 Structure of the broadly neutralizing antibody AP33 MUS MUSCULUS mus musculus mus musculus Potter, J.A., Owsianka, A., Jeffery, N., Matthews, D., Keck, Z., Lau, P., Foung, S.K.H., Taylor, G.L., Patel, A.H. 2.65 X-RAY DIFFRACTION 0.320 0.243 False False IGHV3 IGKV3 Kappa None None None None None 6gk4 C NA 0 A protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 Human NBD1 of CFTR in complex with nanobodies D12 and T8 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.91 X-RAY DIFFRACTION 0.295 0.246 False True IGHV1 None None None None None 6arp D C 0 IMMUNE SYSTEM 08/23/17 Structure of a mutant Cetuximab Fab fragment HOMO SAPIENS homo sapiens homo sapiens Christie, M., Christ, D. 1.7 X-RAY DIFFRACTION 0.197 0.172 False True IGHV2 IGKV5 Kappa None None None None None 4w2p D NA 0 IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C LAMA GLAMA lama glama Taylor, A.B., Garza, J.A. 1.77 X-RAY DIFFRACTION 0.203 0.165 False True IGHV1 None None None None None 2xtj D B 0 A protein proprotein convertase subtilisin/kexin type 9 HYDROLASE/ANTIBODY 10/10/10 The crystal structure of PCSK9 in complex with 1D05 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Di Marco, S., Volpari, C., Carfi, A. 2.7 X-RAY DIFFRACTION 0.25944 0.19992 False True IGHV1 IGKV1D Kappa 4.40e-09 -11.39 SPR 25 20959675 2eiz B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 03/14/07 Crystal structure of humanized HYHEL-10 fv mutant(HW47Y)-hen lysozyme complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Nakanishi, T., Tsumoto, K., Yokota, A., Kondo, H., Kumagai, I. 1.9 X-RAY DIFFRACTION 0.253 0.214 False True IGHV4 IGKV3 Kappa None None None None None 1r3j B A 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 10/02/03 potassium channel KcsA-Fab complex in high concentration of Tl+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y., MacKinnon, R. 1.9 X-RAY DIFFRACTION 0.228 0.208 False False IGHV1 IGKV5 Kappa None None None None None 7czw J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2G7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 1uwe H L 0 ANTIBODY 02/05/04 MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9 MUS MUSCULUS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Baumann, U., Reymond, J.L. 2.67 X-RAY DIFFRACTION 0.271 0.218 False True IGHV1 IGKV6 Kappa None None None None None 7kd6 U V 0 W protein NA insulin receptor subunit alpha SIGNALING PROTEIN 10/08/20 Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G. 2.6 X-RAY DIFFRACTION 0.221 0.189 False True IGHV2 IGKV8 Kappa None None None None None 5hys E F 0 J protein ig epsilon chain c region IMMUNE SYSTEM 02/01/16 Structure of IgE complexed with omalizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Tarchevskaya, S.S., Sathiyamoorthy, K., Jardetzky, T.S. 2.5 X-RAY DIFFRACTION 0.239 0.221 False True IGHV3 IGKV1 Kappa 3.8899999999999996e-11 -14.201849726854265 SPR TBD 7w1s B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/21 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007 Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Yang, J., Lin, S., Sun, H.L., Lu, G.W. 1.997 X-RAY DIFFRACTION 0.224 0.199 False True IGHV1 NA NA None None None None None 7cw3 k l 0 f | e protein | protein NA | NA unknown | unknown VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG (subregion around icosahedral 2-fold vertex) CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 9.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 6h7l D NA 0 B protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.7 X-RAY DIFFRACTION 0.278 0.241 False True IGHV1 None None None None None 1tjg H L 0 P peptide envelope glycoprotein gp41 Viral protein/Immune system 06/04/04 Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 7mer epitope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Wyatt, R., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.225 0.198 False True IGHV2 IGKV1 Kappa None None None None None 4jvp A NA 0 NA NA NA NA IMMUNE SYSTEM 03/26/13 Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 alpaca nanobody D03 VICUGNA PACOS vicugna pacos Krey, T., Rey, F.A. 1.76 X-RAY DIFFRACTION 0.204 0.182 False True IGHV1 NA NA None None None None None 7kqe J M 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/15/20 SARS-CoV-2 spike glycoprotein:Fab 3D11 complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Asarnow, D., Charles, C., Cheng, Y. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 1afv K M 0 B protein human immunodeficiency virus type 1 capsidprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/14/97 HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Momany, C., Kovari, L.C., Prongay, A.J., Keller, W., Gitti, R.K., Lee, B.M., Gorbalenya, A.E., Tong, L., Mcclure, J., Ehrlich, L.S., Summers, M.F., Carter, C., Rossmann, M.G. 3.7 X-RAY DIFFRACTION 0.324 0.217 False False IGHV1 IGKV3 Kappa None None None None None 1qfw I M 0 B protein gonadotrophin beta subunit IMMUNE SYSTEM 04/15/99 TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Tegoni, M., Spinelli, S., Cambillau, C. 3.5 X-RAY DIFFRACTION 0.310 0.260 False True IGHV5 IGKV6 Kappa 1e-08 -10.913952715282035 Unknown TBD 4k3h NA D 0 D Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 5uk4 f NA 0 F protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 5ir3 NA A 0 IMMUNE SYSTEM 03/11/16 Crystal structure of the recombinant highest fibrillogenic natural mutant (obtained from patient AR) derived from lambda 6 light chain variable domain HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A. 1.7 X-RAY DIFFRACTION 0.207 0.174 False True IGLV6 Lambda None None None None None 4uim H L 0 03/30/15 crystal structure of quinine-dependent Fab 314.3 MUS MUSCULUS mus musculus mus musculus Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.2596 0.2215 False False IGHV1 IGKV10 Kappa None None None None None 2hjf A B 0 C protein voltage-gated potassium channel METAL TRANSPORT 06/30/06 Potassium channel kcsa-fab complex with tetrabutylammonium (TBA) MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Faraldo-Gomez, J.D., Kutluay, E., Jogini, V., Zhao, Y., Heginbotham, L., Roux, B. 2.9 X-RAY DIFFRACTION 0.284 0.225 False False IGHV1 IGKV5 Kappa None None None None None 6vo3 H L 0 A protein NA amc009 sosip.v4.2 envelope glycoprotein gp120 IMMUNE SYSTEM 01/29/20 AMC009 SOSIP.v4.2 in complex with PGV04 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., de Val, N., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6x8s H L 0 P peptide NA nand peptide IMMUNE SYSTEM 06/01/20 Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein NAND peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium berghei anka Thai, E., Julien, J.P. 1.55 X-RAY DIFFRACTION 0.185 0.162 False True IGHV1 IGKV1 Kappa None None None None None 6dc7 I M 0 IMMUNE SYSTEM 05/04/18 Apo Fab structure of mouse monoclonal antibody 8B2 MUS MUSCULUS mus musculus mus musculus Chukwu, J.E., Kong, X.-P. 1.901 X-RAY DIFFRACTION 0.235 0.183 False False IGHV1 IGKV1 Kappa None None None None None 7lx5 A NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/03/21 The SARS-CoV-2 spike protein receptor binding domain bound to neutralizing nanobodies WNb 2 and WNb 10 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Pymm, P., Glukhova, A., Tham, W.-H. 3.44 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4poz D C 0 Immune system 02/26/14 Fab fragment of Der p 1 specific antibody 10B9 MUS MUSCULUS mus musculus mus musculus Osinski, T., Majorek, K.A., Pomes, A., Offermann, L.R., Osinski, S., Glesner, J., Vailes, L.D., Chapman, M.D., Minor, W., Chruszcz, M. 1.75 X-RAY DIFFRACTION 0.206 0.169 False True IGHV3 IGKV10 Kappa None None None None None 6b70 E F 0 B protein insulin-degrading enzyme HYDROLASE/IMMUNE SYSTEM/HORMONE 10/03/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 3.7 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 3zhd B NA 0 12/21/12 The crystal structure of single domain antibody 8-4 scaffold. HOMO SAPIENS homo sapiens Song, H.-N., Woo, E.-J., Lim, H.-K. 1.962 X-RAY DIFFRACTION 0.2311 0.1779 False True IGHV3 None None None None None 4qlr A NA 0 IMMUNE SYSTEM 06/13/14 Llama nanobody n02 raised against EAEC T6SS TssM LAMA GLAMA lama glama Nguyen, V.S., Desmyter, A., Le, T.T.H., Durand, E., Kellenberger, C., Douzi, B., Spinelli, S., Cascales, E., Cambillau, C., Roussel, A. 1.7 X-RAY DIFFRACTION 0.251 0.205 False True IGHV1 None None None None None 1acy H L 0 P peptide hiv-1 gp120 (mn isolate) COMPLEX(ANTIBODY/HIV-1 FRAGMENT) 02/10/94 CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1 MUS MUSCULUS; HIV-1 M:B_MN mus musculus mus musculus hiv-1 m Ghiara, J.B., Wilson, I.A. 3.0 X-RAY DIFFRACTION unknown 0.210 False True IGHV12 IGKV3 Kappa None None None None None 6ugv A B 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a I-centered orthorhombic crystal form, Lot C HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H.D. 2.4 X-RAY DIFFRACTION 0.210 0.153 False True IGHV6 IGKV5 Kappa None None None None None 3piq J K 0 IMMUNE SYSTEM 11/07/10 Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1 HOMO SAPIENS homo sapiens homo sapiens Changela, A., Gorny, M.K., Zolla-Pazner, S., Kwong, P.D. 3.325 X-RAY DIFFRACTION 0.299 0.236 False True IGHV3 IGLV3 Lambda None None None None None 4q2z H L 0 IMMUNE SYSTEM 04/10/14 Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE356, from a non-human primate MACACA MULATTA macaca mulatta macaca mulatta Navis, M., Tran, K., Bale, S., Phad, G., Guenaga, J., Wilson, R., Soldemo, M., McKee, K., Sundling, C., Mascola, J., Li, Y., Wyatt, R.T., Hedestam, G.B.K. 1.93 X-RAY DIFFRACTION 0.272 0.232 False True IGHV1 IGLV1 Lambda None None None None None 4r4n J K 0 I | v protein | peptide NA | NA m48u1 peptide | unknown VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | synthetic construct Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 2vxv H L 0 IMMUNE SYSTEM 07/10/08 Crystal structure of human IgG ABT-325 Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Argiriadi, M.A., Xiang, T., Wu, C., Ghayur, T., Borhani, D.W. 1.49 X-RAY DIFFRACTION 0.179 0.153 False True IGHV5 IGKV3 Kappa None None None None None 4rx4 A D 0 E protein hiv-1 clade a q842.d12 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/08/14 Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC134 in complex with HIV-1 clade A Q842.d12 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Acharya, P., Moquin, S., Kwong, P.D. 3.45 X-RAY DIFFRACTION 0.253 0.208 False True unknown IGKV3 Kappa None None None None None 6h6z C NA 0 A | B protein | protein NA | NA capsid protein vp1 | capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-62 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) | norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 2.085 X-RAY DIFFRACTION 0.217 0.178 False True IGHV1 NA NA None None None None None 7a17 F NA 0 E protein NA isoform 2 of synaptojanin-1 HYDROLASE 08/12/20 Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Paesmans, J., Galicia, C., Martin, E., Versees, W. 2.73 X-RAY DIFFRACTION 0.257 0.196 False True IGHV1 NA NA None None None None None 2kqm NA A 11 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7wpv H L 0 NA NA NA NA PROTEIN BINDING 01/24/22 Fab14 - a SARS-CoV2 RBD neutralising antibody HOMO SAPIENS homo sapiens homo sapiens Lin, J.Q., El Sahili, A., Lescar, J. 2.46 X-RAY DIFFRACTION 0.256 0.210 False True IGHV6 IGLV2 Lambda None None None None None 6rlm M N 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 3eak B NA 0 IMMUNE SYSTEM 08/26/08 NbBCII10 humanized (FGLA mutant) CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., Conrath, K. 1.95 X-RAY DIFFRACTION 0.252 0.215 False True IGHV1 None None None None None 7r8o M N 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C548 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 DeLaitsch, A.T., Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV9 Lambda None None None None None 7kfe H J 0 C protein NA spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-329 HOMO SAPIENS; BUNDIBUGYO EBOLAVIRUS homo sapiens homo sapiens bundibugyo ebolavirus Murin, C.D., Ward, A.B. 6.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6ks1 H L 0 A protein NA adiponectin receptor protein 2 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/22/19 Crystal structure of the human adiponectin receptor 2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S. 2.4 X-RAY DIFFRACTION 0.267 0.229 False True IGHV1 IGKV12 Kappa None None None None None 2qtj B M 4 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6bi0 H L 0 IMMUNE SYSTEM 10/31/17 Trastuzumab Fab N158A, D185A, K190A (Light Chain) Triple Mutant. HOMO SAPIENS homo sapiens homo sapiens DiDonato, M., Spraggon, G. 2.057 X-RAY DIFFRACTION 0.230 0.199 False True IGHV3 IGKV1 Kappa None None None None None 5dfv C D 0 A protein cd81 antigen IMMUNE SYSTEM 08/27/15 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH MURINE FAB FRAGMENT K04 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Harris, S.F., Wong, A., Kuglstatter, A. 2.8 X-RAY DIFFRACTION 0.291 0.239 False False IGHV1 IGKV3 Kappa 5e-10 -12.68887519701207 SPR TBD 7rxj H L 0 I protein NA circumsporozoite protein IMMUNE SYSTEM 08/23/21 Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 2.345 X-RAY DIFFRACTION 0.249 0.218 False True IGHV3 IGLV3 Lambda None None None None None 5y7z C NA 0 A protein cyclin-g-associated kinase TRANSFERASE/IMMUNE SYSTEM 08/18/17 Complex structure of cyclin G-associated kinase with gefitinib HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Ohbayashi, N., Murayama, K., Kato-Murayama, M., Shirouzu, M. 2.804 X-RAY DIFFRACTION 0.288 0.233 False True IGHV3 1.5400000000000002e-08 -10.658128680238939 Unknown TBD 6uud H L 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM 10/30/19 Crystal structure of antibody 5D5 in complex with PfCSP N-terminal peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Thai, E., Scally, S.W., Julien, J.P. 1.85 X-RAY DIFFRACTION 0.224 0.178 False True IGHV1 IGKV6 Kappa None None None None None 7kf1 H L 0 V protein NA isoform l-vegf206 of vascular endothelial growth factor a IMMUNE SYSTEM 10/13/20 Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M.S. 2.45 X-RAY DIFFRACTION 0.232 0.189 False True IGHV3 IGKV1 Kappa None None None None None 4unt NA E 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 6be4 H L 0 H carbohydrate NAG polysaccharide IMMUNE SYSTEM 10/24/17 Crystal structure of a polysaccharide-binding human Fab (F598) in complex with nona-N-acetyl-D-glucosamine (9NAc) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Soliman, C., Ramsland, P.A. 1.9 X-RAY DIFFRACTION 0.210 0.164 False True IGHV4 IGLV4 Lambda None None None None None 7vl8 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/02/21 Cryo-EM structure of the Apo CCR1-Gi complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Shao, Z., Shen, Q., Mao, C., Yao, B., Chen, L., Zhang, H., Shen, D., Zhang, C., Li, W., Du, X., Li, F., Ma, H., Chen, Z., Xu, H.E., Ying, S., Zhang, Y., Shen, H. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6x3t J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 2.55 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 6wtu E F 0 D protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 273264 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.55 X-RAY DIFFRACTION 0.255 0.208 False True IGHV3 IGLV3 Lambda None None None None None 4s1d E F 0 E Hapten 41M N~6~-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}-L-lysinamide IMMUNE SYSTEM 01/13/15 Structure of IgG1 Fab fragment in complex with Biotincytidinamide MUS MUSCULUS mus musculus mus musculus mus musculus Dengl, S., Hoffmann, E., Grote, M., Wagner, C., Mundigl, O., Georges, G., Theorey, I., Stubenrauch, K.-G., Bujotzek, A., Josel, H.-P., Dziadek, S., Benz, J., Brinkmann, U. 2.5 X-RAY DIFFRACTION 0.274 0.225 False True IGHV14 IGKV12 Kappa None None None None None 4k07 NA G 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 1tjh H L 0 P peptide envelope glycoprotein gp41 Viral protein/Immune system 06/04/04 Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 11mer epitope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Wyatt, R., Kwong, P.D. 2.1 X-RAY DIFFRACTION 0.233 0.200 False True IGHV2 IGKV1 Kappa None None None None None 5t5b H L 0 E protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 08/30/16 CRYSTAL STRUCTURE OF THE COMPLEX OF 10E8 FAB LIGHT CHAIN MUTANT5 AND T117V2 HIV-1 MPER SCAFFOLD SYNTHETIC CONSTRUCT; HOMO SAPIENS homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.07 X-RAY DIFFRACTION 0.216 0.178 False True IGHV3 IGLV3 Lambda 1.2300000000000001e-10 -13.519788377213574 SPR TBD 1nld H L 0 IMMUNOGLOBULIN 07/02/96 FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1 MUS MUSCULUS mus musculus mus musculus Davies, C., Beauchamp, J.C., Emery, D., Rawas, A., Muirhead, H. 2.9 X-RAY DIFFRACTION 0.326 0.198 False False IGHV2 IGKV1 Kappa None None None None None 5boz L NA 0 F protein ricin Hydrolase/Immune system 05/27/15 Ricin A chain bound to camelid nanobody (VHH9)(E1) RICINUS COMMUNIS; LAMA GLAMA lama glama ricinus communis Rudolph, M.J., Mantis, N. 3.1 X-RAY DIFFRACTION 0.277 0.215 False True IGHV1 7e-10 -12.489520888040902 SPR TBD 7tzg B b 0 C protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 02/15/22 LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition HOMO SAPIENS homo sapiens homo sapiens Ming, Q., Tran, T.H., Luca, V.C. 3.71 X-RAY DIFFRACTION 0.275 0.226 True True unknown unknown unknown None None None None None 5g64 I M 0 B protein ig epsilon chain c region IMMUNE SYSTEM 06/14/16 The complex between human IgE-Fc and two anti-IgE Fab fragments HOMO SAPIENS homo sapiens homo sapiens homo sapiens Davies, A.M., Allan, E.G., Keeble, A.H., Delgado, J., Cossins, B.P., Mitropoulou, A.N., Pang, M.O.Y., Ceska, T., Beavil, A.J., Craggs, G., Westwood, M., Henry, A.J., McDonnell, J.M., Sutton, B.J. 3.715 X-RAY DIFFRACTION 0.309 0.259 False True IGHV3 IGKV1 Kappa None None None None None 3ffd A B 0 P peptide parathyroid hormone-related protein IMMUNE SYSTEM/HORMONE 12/03/08 Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Mckinstry, W.J., Polekhina, G., Diefenbach-Jagger, H., Ho, P.W.M., Sato, K., Onuma, E., Gillespie, M.T., Martin, T.J., Parker, M.W. 2.0 X-RAY DIFFRACTION 0.271 0.224 False True IGHV5 IGLV3 Lambda None None None None None 7ls9 D F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/17/21 Cryo-EM structure of neutralizing antibody 1-57 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5tfs H L 0 IMMUNE SYSTEM 09/26/16 Structure of chimeric 02-K Fab, a VRC01-like germline antibody HOMO SAPIENS homo sapiens homo sapiens Pancera, M. 2.319 X-RAY DIFFRACTION 0.228 0.201 False True IGHV1 IGKV3 Kappa None None None None None 6vmk c b 0 d protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False False IGHV1 IGKV1 Kappa None None None None None 7zmr K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2*-011 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.3 X-RAY DIFFRACTION 0.292 0.243 False True IGHV1 NA NA None None None None None 7x7o G I 0 A protein NA spike protein s1 VIRAL PROTEIN 03/10/22 SARS-CoV-2 spike RBD in complex with neutralizing antibody UT28K SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozawa, T., Tani, H., Anraku, Y., Kita, S., Igarashi, E., Saga, Y., Inasaki, N., Kawasuji, H., Yamada, H., Sasaki, S., Somekawa, M., Sasaki, J., Hayakawa, Y., Yamamoto, Y., Morinaga, Y., Kurosawa, N., Isobe, M., Fukuhara, H., Maenaka, K., Hashiguchi, T., Kishi, H., Kitajima, I., Saito, S., Niimi, H. 3.75 X-RAY DIFFRACTION 0.336 0.303 False True IGHV1 IGKV3 Kappa None None None None None 3okm B A 0 IMMUNE SYSTEM 08/25/10 Crystal structure of unliganded S25-39 MUS MUSCULUS mus musculus mus musculus Blackler, R.J., Evans, S.V. 2.4 X-RAY DIFFRACTION 0.306 0.229 False False IGHV7 IGKV8 Kappa None None None None None 5lxg H L 0 A protein adiponectin receptor protein 1 MEMBRANE PROTEIN 09/21/16 Revised crystal structure of the human adiponectin receptor 1 in an open conformation MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Leyrat, C., Vasiliauskaite-Brooks, I., Granier, S. 2.73 X-RAY DIFFRACTION 0.234 0.225 False True IGHV1 IGKV12 Kappa None None None None None 6qd6 G NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 6eqc D d 0 A protein hexon protein VIRAL PROTEIN 10/12/17 Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon MUS MUSCULUS; HUMAN ADENOVIRUS 5 mus musculus human adenovirus 5 Schmid, M., Ernst, P., Honegger, A., Suomalainen, M., Zimmermann, M., Braun, L., Stauffer, S., Thom, C., Dreier, B., Eibauer, M., Kipar, A., Vogel, V., Greber, U.F., Medalia, O., Plueckthun, A. 7.4 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 3qxw C NA 0 IMMUNE SYSTEM 03/02/11 Free structure of an anti-methotrexate CDR1-4 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.85 X-RAY DIFFRACTION 0.238 0.189 False True IGHV1 None None None None None 3bn9 F E 0 A protein membrane-type serine protease 1 HYDROLASE 12/13/07 Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Farady, C.J., Schneider, E.L., Egea, P.F., Goetz, D.H., Craik, C.S. 2.173 X-RAY DIFFRACTION 0.267 0.223 False True IGHV3 IGKV1 Kappa None None None None None 2kqm NA A 10 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 3c6s F E 0 F carbohydrate RAM polysaccharide IMMUNE SYSTEM 02/05/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag pentadecasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.251 0.191 False False IGHV6 IGKV2 Kappa None None None None None 5m76 NA B 0 IMMUNE SYSTEM 10/26/16 Crystal structure of cardiotoxic Bence-Jones light chain dimer H10 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.5 X-RAY DIFFRACTION 0.282 0.239 False False unknown unknown None None None None None 7nd9 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-253H55L Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6b3s H L 0 A protein epidermal growth factor receptor TRANSFERASE/immune system 09/23/17 Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Bagchi, A. 2.8 X-RAY DIFFRACTION 0.245 0.208 False True IGHV4 IGKV3 Kappa 1.2000000000000002e-08 -10.805930168369423 SPR TBD 1lk3 H L 0 A protein interleukin-10 IMMUNE SYSTEM 04/23/02 ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Josephson, K., Jones, B.C., Walter, L.J., DiGiacomo, R., Indelicato, S.R., Walter, M.R. 1.91 X-RAY DIFFRACTION 0.240 0.187 False False IGHV1 IGKV3 Kappa None None None None None 1ieh A NA 9 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 4krm J NA 0 I protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.655 X-RAY DIFFRACTION 0.244 0.208 False True IGHV1 None None None None None 3t3m E F 0 C protein integrin alpha-iib CELL ADHESION 07/25/11 A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, J., Zhu, J., Springer, T.A. 2.6 X-RAY DIFFRACTION 0.222 0.179 False True IGHV14 IGKV14 Kappa None None None None None 3cm9 D O 3 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5mo3 H L 0 A peptide microtubule-associated protein tau IMMUNE SYSTEM 12/13/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 8.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M. 1.69 X-RAY DIFFRACTION 0.235 0.189 False False IGHV1 IGKV8 Kappa None None None None None 6x1t G I 0 R peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 2.34 X-RAY DIFFRACTION 0.269 0.244 False True IGHV1 IGKV1 Kappa None None None None None 1mcs NA B 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 6cuf H L 0 D protein envelope glycoprotein gp41 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 mus musculus mus musculus human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7p77 X NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7rd5 D C 0 E protein NA tetraspanin-15 CELL ADHESION 07/09/21 Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Lipper, C.H., Gabriel, K.H., Seegar, T.C.M., Durr, K.L., Tomlinson, M.G., Blacklow, S.C. 3.6 X-RAY DIFFRACTION 0.309 0.271 False True IGHV1 IGKV15 Kappa None None None None None 7lk9 H L 0 NA NA NA NA IMMUNE SYSTEM 02/01/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC + COVD21-C8 LC HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 3.4 X-RAY DIFFRACTION 0.312 0.276 False True IGHV3 IGKV3 Kappa None None None None None 3ztj K L 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/VIRAL PROTEIN 07/08/11 Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H3 Influenza haemagglutinin. HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Voss, J.E., Vachieri, S.G., Gamblin, S.J., Collins, P.J., Haire, L.F., Skehel, J.J. 3.41 X-RAY DIFFRACTION 0.28434 0.23410 False True IGHV3 IGKV4 Kappa None None None None None 6z43 X NA 0 A protein spike glycoprotein VIRAL PROTEIN 06/03/20 Cryo-EM Structure of SARS-CoV-2 Spike : H11-D4 Nanobody Complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Ruza, R.R., Duyvesteyn, H.M.E., Shah, P., Carrique, L., Ren, J., Malinauskas, T., Zhou, D., Stuart, D.I., Naismith, J.H. 3.3 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6nc2 O T 0 I | C protein | protein NA | NA amc011 v4.2 sosip gp41 | amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B. 5.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7n05 H L 0 E peptide NA hiv-1 gp41 immunodominant region IMMUNE SYSTEM 05/25/21 Crystal structure of the F240 antibody fragment bound to the HIV-1 gp41 immunodominant region HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 06tg.ht008 Cook, J.D., Lee, J.E. 1.7 X-RAY DIFFRACTION 0.204 0.172 False True unknown IGKV4 Kappa None None None None None 6t9e H L 0 D protein NA unknown IMMUNE SYSTEM 10/28/19 Crystal structure of a bispecific DutaFab in complex with human PDGF HOMO SAPIENS Kimbung, R., Logan, D.T., Beckmann, R., Jensen, K., Speck, J., Fenn, S., Kettenberger, H. 2.989 X-RAY DIFFRACTION 0.304 0.253 False False IGHV3 IGKV1 Kappa None None None None None 7mlh E D 0 B protein NA der p 2 variant 3 ALLERGEN/IMMUNE SYSTEM 04/28/21 Crystal structure of human IgE (2F10) in complex with Der p 2.0103 HOMO SAPIENS; DERMATOPHAGOIDES PTERONYSSINUS homo sapiens homo sapiens dermatophagoides pteronyssinus Khatri, K., Kapingidza, A.B., Richardson, C.M., Vailes, L.D., Wunschmann, S., Dolamore, C., Chapman, M.D., Smith, S.A., Pomes, A., Chruszcz, M. 2.1 X-RAY DIFFRACTION 0.247 0.210 False True IGHV1 IGKV1 Kappa None None None None None 6b0n H L 0 G protein envelope glycoprotein gp140 Viral protein/immune system 09/14/17 Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Sarkar, A., Irimia, A., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.346 0.335 False True IGHV4 unknown unknown None None None None None 3ijh D C 0 C carbohydrate KO2 PROP-2-EN-1-YL D-GLYCERO-ALPHA-D-TALO-OCT-2-ULOPYRANOSIDONIC ACID IMMUNE SYSTEM 08/04/09 Structure of S67-27 in Complex with Ko MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.1 X-RAY DIFFRACTION 0.254 0.213 False False IGHV7 IGKV8 Kappa 9.999999999999999e-05 -5.456976357641017 Unknown TBD 3mj8 B A 0 IMMUNE SYSTEM 04/12/10 Crystal structure of HL4E10 Fab, a hamster Ab stimulatory for gammadelta T cells CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius Verdino, P., Wilson, I.A. 2.94 X-RAY DIFFRACTION 0.281 0.227 False False IGHV2 IGLV3 Lambda None None None None None 6csf H L 0 M protein sodium/alanine symporter agcs MEMBRANE PROTEIN 03/20/18 Crystal structure of sodium/alanine symporter AgcS with D-alanine bound METHANOCOCCUS MARIPALUDIS (STRAIN S2 / LL); MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis (strain s2 / ll) Ma, J., Reyes, F.E., Gonen, T. 3.3 X-RAY DIFFRACTION 0.253 0.240 False False IGHV6 IGKV12 Kappa None None None None None 4rnr A B 0 B carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/24/14 Crystal structure of broadly neutralizing anti-HIV antibody PGT130 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.758 X-RAY DIFFRACTION 0.269 0.244 False True IGHV4 IGLV2 Lambda None None None None None 6bp2 H L 0 A protein envelope glycoprotein VIRAL PROTEIN/immune system 11/21/17 Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein MARBURG MARBURGVIRUS; HOMO SAPIENS homo sapiens homo sapiens marburg marburgvirus King, L.B., Fusco, M.L., Flyak, A.I., Ilinykh, P.A., Huang, K., Gunn, B., Kirchdoerfer, R.N., Hastie, K.M., Sangha, A.K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J.E.J., Saphire, E.O. 3.172 X-RAY DIFFRACTION 0.284 0.252 False True IGHV4 IGLV1 Lambda None None None None None 6txz K O 0 D protein hepatitis a virus cellular receptor 2 IMMUNE SYSTEM 04/08/20 FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Musil, D., Sood, V. 3.06 X-RAY DIFFRACTION 0.253 0.197 False True IGHV3 IGLV2 Lambda None None None None None 7the B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/10/22 Structure of RBD directed antibody DH1042 in complex with SARS-CoV-2 spike: Local refinement of RBD-Fab interface SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 May, A.J., Manne, K., Acharya, P. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3k81 B NA 0 C protein mp18 rna editing complex protein Immune System, RNA Binding Protein 10/13/09 Structure of the central interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies TRYPANOSOMA BRUCEI; LAMA GLAMA lama glama trypanosoma brucei Park, Y.-J., Hol, W. 3.4 X-RAY DIFFRACTION 0.320 0.267 False True IGHV1 None None None None None 7nvn n NA 0 e protein NA unknown CHAPERONE 03/15/21 Human TRiC complex in closed state with nanobody and tubulin bound HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W. 3 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 5hgg S NA 0 B protein urokinase-type plasminogen activator HYDROLASE/INHIBITOR 01/08/16 Crystal structure of uPA in complex with a camelid-derived antibody fragment VICUGNA PACOS; HOMO SAPIENS vicugna pacos homo sapiens Yung, K.W.Y., Kromann-Hansen, T., Andreasen, P.A., Ngo, J.C.K. 1.97 X-RAY DIFFRACTION 0.196 0.167 False True IGHV1 5.4e-11 -14.00752112555336 SPR TBD 3ifo H L 0 P peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 2.15 X-RAY DIFFRACTION 0.218 0.162 False True IGHV8 IGKV1 Kappa 5.45e-08 -9.9 SPR 25 19923222 5veb A B 0 X protein cadherin-6 IMMUNE SYSTEM 04/04/17 Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhu, X., Bialucha, C.U., London, A., Clark, K., Hu, T. 2.34 X-RAY DIFFRACTION 0.252 0.212 False False IGHV3 IGKV1 Kappa None None None None None 6pdx M N 0 B protein hemagglutinin IMMUNE SYSTEM 06/19/19 Crystal structure of C585 Fab in complex with influenza virus hemagglutinin from A/Switzerland/9715293/2013 (H3N2) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Qiu, Y., Zhou, Y. 3.993 X-RAY DIFFRACTION 0.242 0.212 False True IGHV4 IGLV1 Lambda None None None None None 5f7n D NA 0 B protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group A Lewis b pentasaccharide HELICOBACTER PYLORI helicobacter pylori helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.28 X-RAY DIFFRACTION 0.197 0.171 False True IGHV1 None None None None None 3qum K M 0 Q protein prostate-specific antigen IMMUNE SYSTEM 02/24/11 Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Stura, E.A., Muller, B.H., Michel, S., Ducancel, F. 3.2 X-RAY DIFFRACTION 0.294 0.198 False False IGHV1 IGKV2 Kappa None None None None None 3qo1 B A 0 IMMUNE SYSTEM 02/09/11 Monoclinic form of IgG1 Fab fragment (apo form) sharing same Fv as IgA HOMO SAPIENS homo sapiens homo sapiens Trajtenberg, F., Correa, A., Buschiazzo, A. 2.4 X-RAY DIFFRACTION 0.224 0.166 False False IGHV3 IGKV2 Kappa None None None None None 3bd3 NA A 0 IMMUNE SYSTEM 11/14/07 Crystal structure of single domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals MUS MUSCULUS mus musculus Park, S.K., Kim, J.S. 1.6 X-RAY DIFFRACTION 0.270 0.229 True True IGKV8 Kappa None None None None None 5jrp H L 0 IMMUNE SYSTEM 05/06/16 crystal structure of monoclonal antibody MR78 Fab HOMO SAPIENS homo sapiens homo sapiens Dong, J., Crowe, J. 2.0 X-RAY DIFFRACTION 0.194 0.171 False True IGHV4 IGKV1 Kappa None None None None None 4r7n S T 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 4r7n G H 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 4qth H L 0 IMMUNE SYSTEM 07/08/14 Crystal structure of anti-uPAR Fab 8B12 MUS MUSCULUS mus musculus mus musculus Zhao, B., Yuan, C., Luo, Z., Huang, M. 2.17 X-RAY DIFFRACTION 0.273 0.229 False False IGHV1 IGKV9 Kappa None None None None None 7kgu B A 0 NA NA NA NA IMMUNE SYSTEM 10/18/20 Structure of 2Q1-Fab, an antibody selective for IDH2R140Q-HLA-B*07:02 HOMO SAPIENS homo sapiens homo sapiens Miller, M.S., Aytenfisu, T.Y., Wright, K.M., Gabelli, S.B. 2.4 X-RAY DIFFRACTION 0.269 0.208 False True IGHV3 IGKV1 Kappa None None None None None 5w9h H I 0 G protein mers s VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 2dqj H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/26/06 Crystal structure of hyhel-10 FV (wild-type) complexed with hen egg lysozyme at 1.8A resolution MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.219 0.194 False True IGHV3 IGKV5 Kappa None None None None None 7n28 X Y 0 F protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/28/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Zhou, T., Gao, F. 4.2 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 5od0 H L 0 IMMUNE SYSTEM 07/04/17 Crystal structure of ACPA E4 HOMO SAPIENS homo sapiens homo sapiens Dobritzsch, D., Ge, C., Holmdahl, R. 1.8 X-RAY DIFFRACTION 0.213 0.170 False True IGHV4 IGLV1 Lambda None None None None None 6wo5 A B 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/24/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody 212.1.1 and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 2.619 X-RAY DIFFRACTION 0.250 0.203 False True IGHV1 IGKV2 Kappa None None None None None 4nhh I F 0 D protein 2g12 igg dimer heavy chain IMMUNE SYSTEM 11/05/13 Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 6.5 X-RAY DIFFRACTION 0.366 0.381 False True unknown IGKV1 Kappa None None None None None 6axp D C 0 IMMUNE SYSTEM 09/07/17 Structure of cetuximab with aminoheptanoic acid-linked n-octylarginine meditope variant HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bzymek, K.P., Williams, J.C. 2.484 X-RAY DIFFRACTION 0.228 0.179 False True IGHV2 IGKV5 Kappa 8.5e-06 -6.917510260469774 Unknown TBD 1fsk I H 0 G protein major pollen allergen bet v 1-a IMMUNE SYSTEM 09/11/00 COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 BETULA PENDULA; MUS MUSCULUS mus musculus mus musculus betula pendula Mirza, O., Henriksen, A., Ipsen, H., Larsen, J., Wissenbach, M., Spangfort, M., Gajhede, M. 2.9 X-RAY DIFFRACTION 0.285 0.253 False True IGHV1 IGKV6 Kappa 2.4e-10 -13.12373995487015 Unknown TBD 7pgb A B 0 C protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False True IGHV3 IGKV1 Kappa None None None None None 5tdp B A 0 IMMUNE SYSTEM 09/19/16 Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces HOMO SAPIENS homo sapiens homo sapiens Yin, Y., Carter, P.J. 1.716 X-RAY DIFFRACTION 0.252 0.220 False True IGHV3 IGKV1 Kappa None None None None None 6bkb H L 0 E protein polyprotein IMMUNE SYSTEM 11/08/17 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A HOMO SAPIENS; RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 2.799 X-RAY DIFFRACTION 0.267 0.230 False True IGHV1 IGKV3 Kappa 1.5000000000000002e-09 -12.037965345328766 BLI TBD 6udk A B 0 G protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 7obf A NA 0 NA NA NA NA HYDROLASE 04/22/21 Crystal structure of the human VH antibody domain HEL4 HOMO SAPIENS homo sapiens Belviso, B.D., Caliandro, R., Carrozzini, B. 2.699 X-RAY DIFFRACTION 0.264 0.214 False False IGHV3 NA NA None None None None None 7mxd C D 0 A protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/19/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Gao, F. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5u3n H L 0 A peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.12P Fab in Complex with HIV-1 gp41 MPER Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 2.0 X-RAY DIFFRACTION 0.228 0.182 False True IGHV3 IGKV1 Kappa None None None None None 4y7m B NA 0 D protein type vi secretion protein icmf MEMBRANE PROTEIN 02/15/15 T6SS protein TssM C-terminal domain (835-1129) from EAEC LAMA GLAMA; ESCHERICHIA COLI 2-156-04_S3_C3 lama glama escherichia coli 2-156-04_s3_c3 Nguyen, V.S., Spinelli, S., Durand, E., Roussel, A., Cambillau, C. 1.92 X-RAY DIFFRACTION 0.211 0.183 False True IGHV1 None None None None None 5ocl A NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA vicugna pacos Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 4o5i M N 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 6.501 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 IGLV1 Lambda None None None None None 5t5f H L 0 A protein factor h binding protein variant b24 PROTEIN BINDING 08/30/16 Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5 NEISSERIA MENINGITIDIS; MUS MUSCULUS mus musculus mus musculus neisseria meningitidis Malito, E. 2.98 X-RAY DIFFRACTION 0.273 0.223 False False IGHV1 IGKV2 Kappa 1.9000000000000002e-10 -13.26215294160082 SPR TBD 3vi4 F E 0 B protein integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 09/21/11 Crystal structure of alpha5beta1 integrin headpiece in complex with RGD peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Nagae, M., Nogi, T., Takagi, J. 2.9 X-RAY DIFFRACTION 0.275 0.215 False True IGHV1 IGKV2 Kappa None None None None None 2a0l F E 0 B protein voltage-gated potassium channel Membrane Protein 06/16/05 Crystal structure of KvAP-33H1 Fv complex AEROPYRUM PERNIX; MUS MUSCULUS mus musculus mus musculus aeropyrum pernix Lee, S.Y., Lee, A., Chen, J., Mackinnon, R. 3.9 X-RAY DIFFRACTION 0.392 0.358 False False IGHV3 IGKV4 Kappa None None None None None 6e9i C D 0 IMMUNE SYSTEM 08/01/18 The crystal structure of bovine ultralong antibody BOV-4 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 2.5 X-RAY DIFFRACTION 0.243 0.202 False True IGHV1 IGLV1 Lambda None None None None None 1bey H L 0 ANTIBODY 05/18/98 ANTIBODY TO CAMPATH-1H HUMANIZED FAB HOMO SAPIENS homo sapiens homo sapiens Cheetham, G.M.T., Hale, G., Waldmann, H., Bloomer, A.C. 3.25 X-RAY DIFFRACTION 0.306 0.214 False False IGHV4 IGKV1 Kappa None None None None None 2nz9 F E 0 B protein botulinum neurotoxin type a TOXIN/IMMUNE SYSTEM 11/22/06 Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2 HOMO SAPIENS; CLOSTRIDIUM BOTULINUM clostridium botulinum Stevens, R.C., Arndt, J.W. 3.79 X-RAY DIFFRACTION 0.278 0.224 False False IGHV5 IGKV3 Kappa 6.80e-12 -15.12 Other 23 17173035 3c5s D C 0 IMMUNE SYSTEM 02/01/08 Crystal Structure of monoclonal Fab F22-4 specific for Shigella flexneri 2a O-Ag MUS MUSCULUS mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 2.0 X-RAY DIFFRACTION 0.260 0.199 False False IGHV6 IGKV2 Kappa None None None None None 7bel A B 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-88 and COVOX-45 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.53 X-RAY DIFFRACTION 0.286 0.249 False True IGHV3 IGKV1 Kappa None None None None None 6ev2 C D 0 C carbohydrate BGC polysaccharide IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan in complex with laminarihexaose MUS MUSCULUS mus musculus mus musculus mus musculus Sung, K.H., Josewski, J., Duebel, S., Blankenfeldt, W., Rau, U. 2.403 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV4 Kappa None None None None None 5x2p H L 0 A | B protein | protein NA | NA taste receptor, type 1, member 2a | taste receptor, type 1, member 3 SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-glutamate ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes | oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.608 X-RAY DIFFRACTION 0.228 0.153 False True IGHV1 IGKV3 Kappa None None None None None 6qpg P NA 0 J | K protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit RNA BINDING PROTEIN 02/13/19 Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205 INFLUENZA A VIRUS (STRAIN A/NORTHERN TERRITORY/60/1968 H3N2); CAMELIDAE camelidae influenza a virus (strain a/northernterritory/60/1968 h3n2) | influenza a virus (strain a/northernterritory/60/1968 h3n2) Fan, H.T., Keown, J.R., Fodor, E., Grimes, J.M. 3.34 X-RAY DIFFRACTION 0.305 0.251 False True IGHV3 NA NA None None None None None 4yny C D 0 IMMUNE SYSTEM 03/11/15 Crystal structure of monoclonal anti-human podoplanin antibody NZ-1 RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Fujii, Y., Kitago, Y., Arimori, T., Takagi, J. 1.584 X-RAY DIFFRACTION 0.204 0.168 False True IGHV5 IGLV3 Lambda None None None None None 5thr P Q 0 C protein bg505 sosip gp41 VIRAL PROTEIN 09/30/16 Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 8.9, 8.9 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 6sc5 B NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-Ligand2 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.1 X-RAY DIFFRACTION 0.252 0.219 False True IGHV3 None None None None None 7fjs C A 0 B protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/04/21 Crystal structure of T6 Fab bound to theSARS-CoV-2 RBD of B.1.351 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Zhang, S., Liang, Q. 2.9 X-RAY DIFFRACTION 0.285 0.217 False True IGHV1 IGKV8 Kappa None None None None None 6xbj S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/06/20 Structure of human SMO-D384R complex with Gi HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Qi, X., Long, T., Li, X. 3.88 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5alc H L 0 L Hapten TIQ Ticagrelor IMMUNE SYSTEM 03/07/15 Ticagrelor antidote candidate Fab 72 in complex with ticagrelor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Buchanan, A., Newton, P., Pehrsson, S., Inghardt, T., Antonsson, T., Svensson, P., Sjogren, T., Oster, L., Janefeldt, A., Sandinge, A., Keyes, F., Austin, M., Spooner, J., Penney, M., Howells, G., Vaughan, T., Nylander, S. 1.7 X-RAY DIFFRACTION 0.2367 0.1975 False True IGHV1 IGLV1 Lambda 7.400000000000001e-09 -11.092352568721394 Unknown TBD 7te6 C D 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody XENOPUS LAEVIS; RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | xenopus laevis Regan, M., Tajima, N., Furukawa, H. 4.55 X-RAY DIFFRACTION 0.324 0.282 False False IGHV5 IGKV3 Kappa None None None None None 3cfc H L 0 IMMUNE SYSTEM 03/03/08 High-resolution structure of blue fluorescent antibody EP2-19G2 MUS MUSCULUS mus musculus mus musculus Debler, E.W., Wilson, I.A. 1.7 X-RAY DIFFRACTION 0.231 0.191 False False IGHV5 IGKV2 Kappa None None None None None 1dee F E 0 H protein immunoglobulin g binding protein a IMMUNE SYSTEM 11/15/99 CRYSTAL STRUCTURE AT 2.7A RESOLUTION OF A COMPLEX BETWEEN A STAPHYLOCOCCUS AUREUS DOMAIN AND A FAB FRAGMENT OF A HUMAN IGM ANTIBODY STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus Graille, M., Stura, E.A., Corper, A.L., Sutton, B.J., Taussig, M.J., Charbonnier, J.B., Silverman, G.J. 2.7 X-RAY DIFFRACTION 0.281 0.217 False False IGHV3 IGKV1 Kappa 4e-07 -8.728351841232218 Unknown TBD 7b18 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/24/20 SARS-CoV-spike bound to two neutralising nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; VICUGNA PACOS lama glama severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4nko D C 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.496 X-RAY DIFFRACTION 0.344 0.308 False True IGHV1 IGKV1 Kappa None None None None None 1baf H L 0 L Hapten NPP N-(2-AMINO-ETHYL)-4,6-DINITRO-N'-(2,2,6,6-TETRAMETHYL-1-OXY-PIPERIDIN-4-YL)-BENZENE-1,3-DIAMINE IMMUNOGLOBULIN 01/16/92 2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI-DINITROPHENYL-SPIN-LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN MUS MUSCULUS mus musculus mus musculus Leahy, D.J., Brunger, A.T., Fox, R.O., Hynes, T.R. 2.9 X-RAY DIFFRACTION unknown 0.195 False True IGHV3 IGKV4 Kappa None None None None None 7x7d F NA 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 SARS-CoV-2 Delta RBD and Nb22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Wang, Y., Ye, S. 2.92 X-RAY DIFFRACTION 0.256 0.205 False True IGHV1 NA NA None None None None None 7rai H L 0 A protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 07/01/21 Cryo-EM structure of M4008_N1 Fab in complex with BG505 DS-SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 3.24 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7syy H L 0 A protein NA attachment glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/25/21 Hendra virus G protein head domain in complex with cross-neutralizing murine antibody hAH1.3 HENDRA HENIPAVIRUS; MUS MUSCULUS mus musculus mus musculus hendra henipavirus Xu, K., Xu, Y. 2.74 X-RAY DIFFRACTION 0.233 0.211 False True IGHV9 IGKV1 Kappa None None None None None 6k2i A NA 11 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 4wen B NA 0 A protein k88 fimbrial protein ac STRUCTURAL PROTEIN 09/10/14 Co-complex structure of the F4 fimbrial adhesin FaeG variant ac with llama single domain antibody V2 ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Moonens, K., Van den Broeck, I., Pardon, E., De Kerpel, M., Remaut, H., De Greve, H. 1.89 X-RAY DIFFRACTION 0.226 0.188 False True IGHV1 1e-07 -9.54970862587178 SPR TBD 1s78 D C 0 A protein receptor protein-tyrosine kinase erbb-2 TRANSFERASE 01/29/04 Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Franklin, M.C., Carey, K.D., Vajdos, F.F., Leahy, D.J., de Vos, A.M., Sliwkowski, M.X. 3.25 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV1 Kappa None None None None None 7bxa B C 0 A protein programmed cell death protein 1 IMMUNE SYSTEM 06/10/20 Crystal structure of PD-1 in complex with tislelizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, S.H., Lim, H., Lee, H.T., Kim, Y.J., Park, E.B. 3.32 X-RAY DIFFRACTION 0.299 0.243 False True IGHV4 IGKV4 Kappa None None None None None 7dfp C B 0 A protein NA d(2) dopamine receptor,soluble cytochrome b562 MEMBRANE PROTEIN 11/09/20 Human dopamine D2 receptor in complex with spiperone HOMO SAPIENS; ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus homo sapiens, escherichia coli Im, D., Shimamura, T., Iwata, S. 3.1 X-RAY DIFFRACTION 0.217 0.185 False False IGHV1 IGKV10 Kappa None None None None None 7zf4 F NA 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-9 Fab and nanobody F2 LAMA GLAMA; HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.18 X-RAY DIFFRACTION 0.385 0.370 False True IGHV1 NA NA None None None None None 7ldd K J 0 D protein NA glutamate receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV10 Kappa None None None None None 5kel M O 0 F protein ebola surface glycoprotein, gp1 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 ZAIRE EBOLAVIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV8 IGKV6 Kappa None None None None None 3kym N M 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 7n8h H G 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/14/21 SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4n1h D NA 0 C protein beta-lactamase HYDROLASE/IMMUNE SYSTEM 10/04/13 Structure of a single-domain camelid antibody fragment cAb-F11N in complex with the BlaP beta-lactamase from Bacillus licheniformis LAMA GLAMA; BACILLUS LICHENIFORMIS lama glama bacillus licheniformis Pain, C., Kerff, F., Herman, R., Sauvage, E., Preumont, S., Charlier, P., Dumoulin, M. 3.0 X-RAY DIFFRACTION 0.284 0.208 False True IGHV1 None None None None None 7mxp H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/19/21 Cryo-EM structure of NTD-directed neutralizing antibody LP5 Fab in complex with SARS-CoV-2 S2P spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Casner, R.G., Shapiro, L. 4.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7ryv P Q 0 NA NA NA NA IMMUNE SYSTEM 08/26/21 Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques MACACA MULATTA macaca mulatta macaca mulatta Yang, Z., Bjorkman, P.J. 2.5 X-RAY DIFFRACTION 0.254 0.216 False True IGHV1 IGLV1 Lambda None None None None None 6weq I J 0 C protein NA non-structural protein 1 VIRAL PROTEIN 04/02/20 DENV1 NS1 in complex with neutralizing 2B7 Fab fragment DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Akey, D.L., Smith, J.L. 3.2 X-RAY DIFFRACTION 0.261 0.207 False False IGHV1 IGKV3 Kappa None None None None None 3chn B M 3 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 6ey6 O NA 0 G protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 7c8w A NA 0 B protein NA spike glycoprotein PROTEIN BINDING 06/03/20 Structure of sybody MR17 in complex with the SARS-CoV-2 S receptor-binding domain (RBD) SYNTHETIC CONSTRUCT; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 synthetic construct severe acute respiratory syndrome coronavirus2 Li, T., Cai, H., Yao, H., Qin, W., Li, D. 2.77 X-RAY DIFFRACTION 0.267 0.205 False True IGHV1 NA NA None None None None None 5umn E F 0 A protein hemagglutinin IMMUNE SYSTEM 01/27/17 Crystal structure of C05 VPGSGW mutant bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Wu, N.C., Wilson, I.A. 1.97 X-RAY DIFFRACTION 0.208 0.181 False True IGHV3 IGKV1 Kappa None None None None None 5xaj F D 0 IMMUNE SYSTEM 03/13/17 Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex. DENGUE VIRUS dengue virus dengue virus Wong, Y.H., Goh, B.C., Lescar, J. 2.5 X-RAY DIFFRACTION 0.239 0.185 False True IGHV1 IGLV3 Lambda None None None None None 1ru9 H L 0 immune system 12/11/03 Crystal Structure (A) of u.v.-irradiated cationic cyclization antibody 4C6 Fab at pH 4.6 with a data set collected in-house. MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.247 0.192 False False IGHV3 IGKV1 Kappa None None None None None 7czv J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B6_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6pdr H L 0 A peptide NA hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/19/19 Vaccine-elicited murine FP-targeting antibody vFP25.18 in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 1.555 X-RAY DIFFRACTION 0.200 0.175 False True IGHV1 IGKV1 Kappa None None None None None 7vne U NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/10/21 Structure of the SARS-CoV-2 spike glycoprotein in complex with a human single domain antibody n3113.1 (UUU-state) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Yang, Z., Wang, Y., Kong, Y., Jin, Y., Wu, Y., Ying, T. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ur4 F G 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/21/22 Cryo-EM Structure of the Neutralizing Antibody MPV467 in Complex with Prefusion Human Metapneumovirus F Glycoprotein HUMAN METAPNEUMOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human metapneumovirus Rush, S.A., McLellan, J.S. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 5nj3 E F 0 A protein atp-binding cassette sub-family g member 2 TRANSPORT PROTEIN 03/28/17 Structure of an ABC transporter: complete structure MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Taylor, N.M.I., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P. 3.78 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 5ewi H L 0 IMMUNE SYSTEM 11/20/15 Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90 homo sapiens homo sapiens Gorman, J., Kwong, P.D. 1.5996 X-RAY DIFFRACTION 0.202 0.173 False True IGHV3 IGKV2 Kappa None None None None None 5vak B NA 0 A protein beta-klotho SIGNALING PROTEIN 03/27/17 Crystal Structure of Beta-Klotho, Domain 1 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Lee, S., Schlessinger, J. 1.7 X-RAY DIFFRACTION 0.196 0.172 False True IGHV1 None None None None None 7cth I M 0 B protein NA core protein VIRUS 08/19/20 Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10 DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Zhang, X., Sharma, A., Duquerroy, S., Zhou, Z.H., Rey, F.A. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7bwj H L 0 E protein sars-cov-2 receptor binding domain VIRAL PROTEIN 06/03/20 crystal structure of SARS-CoV-2 antibody with RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Ge, J. 2.85 X-RAY DIFFRACTION 0.264 0.219 False True IGHV4 IGLV2 Lambda None None None None None 7q4q B A 0 E peptide NA lrg1 epitope IMMUNE SYSTEM 11/01/21 Magacizumab Fab fragment in complex with human LRG1 epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Gutierrez-Fernandez, J., Luecke, H. 1.65 X-RAY DIFFRACTION 0.207 0.183 False False IGHV1 IGKV3 Kappa None None None None None 4fqr i j 0 I protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 3chn A L 2 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 1eap B A 0 B Hapten HEP PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATE CATALYTIC ANTIBODY 08/10/94 CRYSTAL STRUCTURE OF A CATALYTIC ANTIBODY WITH A SERINE PROTEASE ACTIVE SITE MUS MUSCULUS mus musculus mus musculus mus musculus Zhou, G.W., Guo, J., Huang, W., Scanlan, T.S., Fletterick, R.J. 2.4 X-RAY DIFFRACTION unknown 0.186 False False IGHV1 IGKV19 Kappa None None None None None 7tyv H L 0 C | c protein | protein NA | NA glycoprotein g2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 02/14/22 Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C LASSA VIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa virus | lassa virus Enriquez, A.S., Hastie, K.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7cwn O M 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4xcn A B 0 A Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA); 2.9 A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.246 0.193 False True IGHV1 IGKV3 Kappa None None None None None 7q9m J K 0 A protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-53 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 5t0y A B 0 IMMUNE SYSTEM 08/17/16 2A10 Antibody FAB fragment MUS MUSCULUS mus musculus mus musculus Jackson, C.J., Fisher, C. 3.011 X-RAY DIFFRACTION 0.247 0.225 False True IGHV9 IGKV10 Kappa None None None None None 7xh8 B C 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/07/22 The structure of ZCB11 Fab against SARS-CoV-2 Omicron Spike Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hang, L., Dang, S. 2.99 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6ikm L l 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 7kd0 C NA 0 B | A protein | protein NA | NA ricin chain b | ricin chain a TOXIN 10/07/20 Ricin bound to VHH antibody V2C11 LAMA GLAMA; RICINUS COMMUNIS lama glama ricinus communis | ricinus communis Rudolph, M.J. 2.768 X-RAY DIFFRACTION 0.255 0.207 False True IGHV1 NA NA None None None None None 5x5x H L 0 IMMUNE SYSTEM 02/18/17 Crystal structure of the Fab fragment of anti-osteocalcin C-terminal peptide antibody KTM219 MUS MUSCULUS mus musculus mus musculus Komatsu, M., Dong, J., Ueda, H., Arai, R. 1.9 X-RAY DIFFRACTION 0.224 0.181 False True IGHV1 IGKV1 Kappa None None None None None 6gs4 H NA 0 A protein dipeptide and tripeptide permease a MEMBRANE PROTEIN 06/13/18 Crystal structure of peptide transporter DtpA-nanobody in complex with valganciclovir ESCHERICHIA COLI K-12; LAMA lama escherichia coli k-12 Ural-Blimke, Y., Flayhan, A., Quistgaard, E.M., Loew, C. 2.645 X-RAY DIFFRACTION 0.239 0.216 False True IGHV1 None None None None None 2dbl H L 0 L Hapten S5H 5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE IMMUNOGLOBULIN 02/08/94 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY MUS MUSCULUS mus musculus mus musculus mus musculus Arevalo, J.H., Wilson, I.A. 2.9 X-RAY DIFFRACTION unknown 0.205 False True IGHV9 IGKV1 Kappa None None None None None 7ur4 I J 0 A protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/21/22 Cryo-EM Structure of the Neutralizing Antibody MPV467 in Complex with Prefusion Human Metapneumovirus F Glycoprotein HUMAN METAPNEUMOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human metapneumovirus Rush, S.A., McLellan, J.S. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 3go1 H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 03/18/09 Crystal structure of anti-HIV-1 Fab 268-D in complex with V3 peptide MN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.P., Burke, V.J. 1.89 X-RAY DIFFRACTION 0.213 0.191 False False IGHV4 IGLV3 Lambda None None None None None 5k9j H L 0 IMMUNE SYSTEM 05/31/16 Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 56.a.09 isolated following H5 immunization. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 1.904 X-RAY DIFFRACTION 0.231 0.195 False True IGHV6 IGKV3 Kappa None None None None None 5i1k H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV5-51/IGKV3-20 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 1.65 X-RAY DIFFRACTION 0.197 0.172 False True IGHV5 IGKV3 Kappa None None None None None 5erw A B 0 C peptide hcv e2 glycoprotein epitope ii VIRAL PROTEIN/IMMUNE SYSTEM 11/15/15 Structure of HCV E2 glycoprotein antigenic Epitope II bound to the broadly neutralizing antibody HC84-26 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Gao, M., Mariuzza, R. 2.9 X-RAY DIFFRACTION 0.258 0.215 False True IGHV1 IGLV3 Lambda None None None None None 6cbj H L 0 L carbohydrate NAG polysaccharide IMMUNE SYSTEM 02/03/18 Crystal Structure of DH270.3 Fab in complex with Man9 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.85 X-RAY DIFFRACTION 0.231 0.204 False True IGHV1 IGLV2 Lambda None None None None None 4p2c I NA 0 D protein NA shiga toxin 2e, subunit b TOXIN 03/03/14 Complex of Shiga toxin 2e with a neutralizing single-domain antibody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Lo, A.W.H., Moonens, K., De Kerpel, M., Brys, L., Pardon, E., Remaut, H., De Greve, H. 2.818 X-RAY DIFFRACTION 0.253 0.187 False True IGHV1 NA NA None None None None None 3upc C NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 4tnw G K 0 C protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False IGHV1 IGLV1 Lambda None None None None None 5d1z F E 0 J protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT1 bound by clone D4-10 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN MSSA476) homo sapiens homo sapiens staphylococcus aureus (strain mssa476) Deng, X. 3.17 X-RAY DIFFRACTION 0.287 0.233 False True IGHV4 IGKV1 Kappa None None None None None 5vxj D NA 0 C protein NA invasin ipad IMMUNE SYSTEM 05/23/17 2.50 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-E3 SHIGELLA FLEXNERI; VICUGNA PACOS vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.5 X-RAY DIFFRACTION 0.259 0.196 False True IGHV1 NA NA None None None None None 6os2 D NA 0 A protein type-1 angiotensin ii receptor,soluble cytochrome b562 brilfusion protein MEMBRANE PROTEIN 05/01/19 Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV026 HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens, escherichia coli Wingler, L.M., Staus, D.P., Skiba, M.A., McMahon, C., Kleinhenz, A.L.W., Lefkowitz, R.J., Kruse, A.C. 2.7 X-RAY DIFFRACTION 0.285 0.233 False True IGHV1 None None None None None 5vai N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 Signaling Protein/Hormone 03/27/17 Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein ORYCTOLAGUS CUNICULUS; HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus norvegicus Zhang, Y., Sun, B., Feng, D., Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Kobilka, T.S., Kobilka, B.K., Skiniotis, G. 4.1 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6qd6 B NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 7o0s A NA 0 B protein NA centrosomal protein of 164 kda STRUCTURAL PROTEIN 03/26/21 Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 36Z CAMELIDAE MIXED LIBRARY; HOMO SAPIENS camelidae mixed library homo sapiens e Silva, I.R., van Breugel, M. 1.7 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 NA NA None None None None None 4trp H L 0 IMMUNE SYSTEM 06/17/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS mus musculus mus musculus Horwacik, I., Golik, P., Grudnik, P., Zdzalik, M., Rokita, H., Dubin, G. 1.25 X-RAY DIFFRACTION 0.178 0.149 False True IGHV1 IGKV1 Kappa None None None None None 6pci N Q 0 A | D protein | protein NA | NA virion spike glycoprotein | virion spike glycoprotein,virion spike glycoprotein,ebolavirus (makona) gp2 immune system, viral protein 06/17/19 EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus | zaire ebolavirus, ebola virus Ward, A.B., Murin, C.D., Alkutkar, T. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 5vco D C 0 E protein peptidase 1 IMMUNE SYSTEM 03/31/17 THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 10B9 MUS MUSCULUS; DERMATOPHAGOIDES PTERONYSSINUS mus musculus mus musculus dermatophagoides pteronyssinus Osinski, T., Majorek, K.A., Pomes, A., Offermann, L.R., Osinski, S., Glesner, J., Vailes, L.D., Chapman, M.D., Minor, W., Chruszcz, M. 2.74 X-RAY DIFFRACTION 0.261 0.200 False True IGHV3 IGKV10 Kappa None None None None None 7urs H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/22/22 Crystal Structure of SARS-CoV-2 S delta variant receptor-binding domain (RBD) in complex CoV11 Fab crystal form 2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tolbert, W.D., Pazgier, M. 2.4 X-RAY DIFFRACTION 0.224 0.179 False True IGHV3 IGKV3 Kappa None None None None None 1bre NA D 0 IMMUNOGLOBULIN 07/19/95 IMMUNOGLOBULIN LIGHT CHAIN PROTEIN HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 2.0 X-RAY DIFFRACTION 0.337 0.218 False True IGKV1 Kappa None None None None None 1etz H L 0 H Hapten GAS ? IMMUNE SYSTEM 04/13/00 THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS MUS MUSCULUS mus musculus mus musculus mus musculus Guddat, L.W., Shan, L., Broomell, C., Ramsland, P.A., Fan, Z., Anchin, J.M., Linthicum, D.S., Edmundson, A.B. 2.6 X-RAY DIFFRACTION 0.294 0.198 False False IGHV8 IGLV1 Lambda 7.30e-08 -9.73 Other 8232332 7x7o E F 0 C protein NA spike protein s1 VIRAL PROTEIN 03/10/22 SARS-CoV-2 spike RBD in complex with neutralizing antibody UT28K SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozawa, T., Tani, H., Anraku, Y., Kita, S., Igarashi, E., Saga, Y., Inasaki, N., Kawasuji, H., Yamada, H., Sasaki, S., Somekawa, M., Sasaki, J., Hayakawa, Y., Yamamoto, Y., Morinaga, Y., Kurosawa, N., Isobe, M., Fukuhara, H., Maenaka, K., Hashiguchi, T., Kishi, H., Kitajima, I., Saito, S., Niimi, H. 3.75 X-RAY DIFFRACTION 0.336 0.303 False True IGHV1 IGKV3 Kappa None None None None None 3chn B M 8 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 4rfn B C 0 A protein hiv-1 clade a/e 93th057 (h375s) gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/26/14 Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Gohain, N., Tolbert, W.D., Pazgier, M. 3.21 X-RAY DIFFRACTION 0.332 0.273 False True IGHV4 IGLV1 Lambda None None None None None 1oay NA O 0 IMMUNE SYSTEM 01/21/03 Antibody multispecificity mediated by conformational diversity RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.66 X-RAY DIFFRACTION 0.280 0.258 False True unknown unknown unknown 1.20e-06 Other 20 12610298 7cn2 J j 0 B protein NA major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 07/29/20 Subparticle refinement of human papillomavirus type 16 pesudovirus in complex with H16.001 Fab HUMAN PAPILLOMAVIRUS TYPE 16; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human papillomavirus type 16 He, M.Z., Li, S.W. 3.43 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 1h8n A a 0 ANTIBODY 02/14/01 THE IMPORTANCE OF FRAMEWORK RESIDUES 6 AND 9 IN THE HEAVY CHAINS OF ANTIBODY FV FRAGMENT MUS MUSCULUS mus musculus Jung, S., Spinelli, S., Schimmele, B., Honegger, A., Pugliese, L., Cambillau, C., Plucktun, A. 1.87 X-RAY DIFFRACTION 0.276 0.233 True True unknown unknown unknown None None None None None 1tzi B A 0 V protein vascular endothelial growth factor a immune system 07/10/04 Crystal Structure of the Fab YADS2 Complexed with h-VEGF MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Fellouse, F.A., Wiesmann, C., Sidhu, S.S. 2.8 X-RAY DIFFRACTION 0.254 0.218 False True IGHV5 IGKV6 Kappa 1.00E-08 -11.35 SPR 37 15306681 3mj8 H L 0 IMMUNE SYSTEM 04/12/10 Crystal structure of HL4E10 Fab, a hamster Ab stimulatory for gammadelta T cells CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius Verdino, P., Wilson, I.A. 2.94 X-RAY DIFFRACTION 0.281 0.227 False False IGHV2 IGLV3 Lambda None None None None None 1iga A C 0 IMMUNOGLOBULIN 12/23/98 MODEL OF HUMAN IGA1 DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING HOMO SAPIENS homo sapiens homo sapiens Boehm, M.K., Woof, J.M., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 3we6 A B 0 IMMUNE SYSTEM 07/01/13 Crystal structure of anti-Prostaglandin E2 Fab fragment MUS MUSCULUS mus musculus mus musculus Sugahara, M., Ago, H., Saino, H., Miyano, M. 2.02 X-RAY DIFFRACTION 0.217 0.188 False False IGHV1 IGKV1 Kappa None None None None None 3b9v B NA 0 IMMUNE SYSTEM 11/06/07 Crystal Structure of an Autonomous VH Domain HOMO SAPIENS homo sapiens Appleton, B.A., Barthelemy, P.A., Wiesmann, C. 1.8 X-RAY DIFFRACTION 0.200 0.155 False True IGHV3 None None None None None 3zdy H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.45 X-RAY DIFFRACTION 0.2156 0.1820 False True IGHV14 IGKV14 Kappa None None None None None 4xwo Q R 0 N protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 2agj H L 0 IMMUNE SYSTEM 07/27/05 Crystal Structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody HOMO SAPIENS homo sapiens homo sapiens Ramsland, P.A., Terzyan, S.S., Cloud, G., Bourne, C.R., Farrugia, W., Tribbick, G., Geysen, H.M., Moomaw, C.R., Slaughter, C.A., Edmundson, A.B. 2.6 X-RAY DIFFRACTION 0.279 0.219 False False IGHV2 IGKV3 Kappa None None None None None 6xqw H L 0 E protein NA pfmsp1-19 IMMUNE SYSTEM 07/10/20 Crystal Structure of MaliM03 Fab in complex with Pfmsp1-19 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum Singh, S., Pancera, M. 2.991 X-RAY DIFFRACTION 0.309 0.252 False True IGHV4 IGLV1 Lambda None None None None None 6wxl F E 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 05/11/20 Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer INFLUENZA A VIRUS (A/SHANGHAI/JS01/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/shanghai/js01/2013(h7n9)) | influenza a virus (a/shanghai/js01/2013(h7n9)) Gorman, J., Kwong, P.D. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 7aql B b 0 NA NA NA NA IMMUNE SYSTEM 10/22/20 Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7) MUS MUSCULUS mus musculus Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 1.8 X-RAY DIFFRACTION 0.223 0.186 True True unknown unknown unknown None None None None None 7tdn H L 0 B protein NA heat-labile enterotoxin b chain MEMBRANE PROTEIN 01/01/22 CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain HOMO SAPIENS; CLOSTRIDIUM PERFRINGENS homo sapiens homo sapiens clostridium perfringens Vecchio, A.J. 5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ecy E F 0 C | A protein | protein NA | NA capsid protein vp2 | capsid protein vp1 VIRUS 03/13/21 EV-D68 in complex with 2H12 Fab (State 3) HUMAN ENTEROVIRUS D68; MUS MUSCULUS mus musculus mus musculus human enterovirus d68 | human enterovirus d68 Xu, C., Cong, Y. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV9 Kappa None None None None None 6qv0 F NA 0 D | C protein | protein NA | NA uncharacterized abc transporter atp-binding proteintm_0288 | abc transporter, atp-binding protein MEMBRANE PROTEIN 03/01/19 Structure of ATP-bound outward-facing TM287/288 in complex with sybody Sb_TM35 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); SYNTHETIC CONSTRUCT synthetic construct thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) | thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 3.12 X-RAY DIFFRACTION 0.264 0.244 False True IGHV1 NA NA None None None None None 7dm1 F E 0 B protein NA phosphate-binding protein psts 1 TRANSPROT PROTEIN/IMMUNE SYSTEM 12/01/20 crystal structure of the M.tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-36 MYCOBACTERIUM TUBERCULOSIS H37RV; HOMO SAPIENS homo sapiens homo sapiens mycobacterium tuberculosis h37rv Ma, B., Freund, N., Xiang, Y. 2.1 X-RAY DIFFRACTION 0.230 0.186 False True IGHV3 IGLV2 Lambda None None None None None 6zhd D NA 0 A protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 06/22/20 H11-H4 bound to Spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Clare, D.K., Naismith, J.H., Weckener, M., Vogirala, V.K. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7r98 D NA 0 A protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/28/21 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody B6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Corbett, K.D., Ye, Q. 2.51 X-RAY DIFFRACTION 0.273 0.226 False True IGHV1 NA NA None None None None None 4rau W V 0 X protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 6ea7 M N 0 B | C | D protein | protein | protein NA | NA | NA envelope glycoprotein | envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN/immune system 08/02/18 Structure of EBOV GPcl in complex with the pan-ebolavirus mAb ADI-15878 ZAIRE EBOLAVIRUS; EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus | zaire ebolavirus | ebola virus West, B.R., Moyer, C.L., King, L.B., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O. 4.25 X-RAY DIFFRACTION 0.324 0.280 False True IGHV3 IGKV1 Kappa None None None None None 1a7o H L 0 IMMUNOGLOBULIN 03/16/98 FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) R96L DELETION MUTANT ON VARIANT FOR CHAIN L GLU81->ASP AND CHAIN H LEU312->VAL MUS MUSCULUS mus musculus mus musculus Marks, C., Henrick, K., Winter, G. 2.0 X-RAY DIFFRACTION unknown 0.167 False True IGHV2 IGKV12 Kappa None None None None None 6x1s C D 0 J peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC1-1) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 1.65 X-RAY DIFFRACTION 0.226 0.200 False True IGHV1 IGKV1 Kappa None None None None None 1u8q B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELEKWAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.238 0.228 False False IGHV2 IGKV1 Kappa None None None None None 3pjs B A 0 M | N protein | protein NA | NA voltage-gated potassium channel | voltage-gated potassium channel TRANSPORT PROTEIN 11/10/10 Mechanism of Activation Gating in the Full-Length KcsA K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans | streptomyces lividans Uysal, S., Cuello, L.G., Kossiakoff, A., Perozo, E. 3.8 X-RAY DIFFRACTION 0.332 0.281 False True IGHV3 IGKV1 Kappa None None None None None 6nfj E NA 0 D protein beta-klotho SIGNALING PROTEIN 12/20/18 Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens Kuzina, E., Schlessinger, J., Lee, S. 3.19 X-RAY DIFFRACTION 0.320 0.280 False True IGHV1 None None None None None 4kfz C NA 0 A protein lmo-2 TRANSCRIPTION 04/28/13 Crystal structure of LMO2 and anti-LMO2 VH complex HOMO SAPIENS homo sapiens homo sapiens Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H. 2.8 X-RAY DIFFRACTION 0.258 0.239 False True IGHV3 9.400000000000001e-08 -9.586368792768159 Unknown TBD 7tc9 H L 0 B protein NA spike protein s1 VIRAL PROTEIN/Immune System 12/23/21 Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhou, T., Kwong, P.D. 5.08 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 3iu3 H L 0 I protein interleukin-2 receptor alpha chain IMMUNE SYSTEM 08/29/09 Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Du, J., Yang, H., Wang, J., Ding, J. 2.9 X-RAY DIFFRACTION 0.262 0.215 False True IGHV1 IGKV4 Kappa 1.40e-10 -13.44 SPR 25 20032294 5jmr A NA 0 IMMUNE SYSTEM 04/29/16 X-ray structure of an camelid VHH fragment CAMELUS DROMEDARIUS camelus dromedarius Dahms, S.O., Than, M.E. 2.27 X-RAY DIFFRACTION 0.216 0.190 False True IGHV3 None None None None None 5f89 H L 0 IMMUNE SYSTEM 12/09/15 Structure of the Unliganded Fab from HIV-1 Neutralising Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface HOMO SAPIENS homo sapiens homo sapiens Wibmer, C.K., Gorman, J., Kwong, P.D. 2.7842 X-RAY DIFFRACTION 0.279 0.228 False True IGHV4 IGLV2 Lambda None None None None None 7zml E NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G1-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.79 X-RAY DIFFRACTION 0.260 0.223 False True IGHV1 NA NA None None None None None 6txz I M 0 B protein hepatitis a virus cellular receptor 2 IMMUNE SYSTEM 04/08/20 FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Musil, D., Sood, V. 3.06 X-RAY DIFFRACTION 0.253 0.197 False True IGHV3 IGLV2 Lambda None None None None None 4rau T S 0 U protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 5whk H L 0 A | B protein | protein NA | NA igg receptor fcrn large subunit p51 | beta-2-microglobulin IMMUNE SYSTEM 07/17/17 Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Edwards, T.E., Clifton, M.C., Nixon, A.E., Kenniston, J.A. 2.5 X-RAY DIFFRACTION 0.225 0.169 False True IGHV3 IGLV2 Lambda 1.8100000000000002e-09 -11.926660331959345 SPR TBD 7kdd D E 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 10/08/20 HCMV postfusion gB in complex with SM5-1 Fab HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS (STRAIN TOWNE) homo sapiens homo sapiens human cytomegalovirus (strain towne) Liu, Y., Heim, P.K., Che, Y., Chi, X., Qiu, X., Han, S., Dormitzer, P.R., Yang, X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 4aj0 NA D 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rCW, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.7 X-RAY DIFFRACTION 0.2116 0.1741 False True IGLV3 Lambda None None None None None 7n08 A B 0 E peptide NA hiv-1 gp41 immunodominant region IMMUNE SYSTEM 05/25/21 Crystal structure of the 3D6 antibody fragment bound to the HIV-1 gp41 immunodominant region HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 06tg.ht008 Cook, J.D., Lee, J.E. 2.0 X-RAY DIFFRACTION 0.203 0.165 False True IGHV3 IGKV1 Kappa None None None None None 2gsi B A 0 W peptide thermonuclease IMMUNE SYSTEM 04/26/06 Crystal Structure of a Murine Fab in Complex with an 11 Residue Peptide Derived from Staphylococcal Nuclease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Armstrong, A.A., Amzel, L.M. 2.81 X-RAY DIFFRACTION 0.293 0.221 False False IGHV14 IGKV3 Kappa None None None None None 7lfd H L 0 A peptide NA apolipoprotein l1 bh3 like peptide IMMUNE SYSTEM 01/16/21 Fab 7D6 bound to ApoL1 BH3 like peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Ultsch, M., Kirchhofer, D. 2.157 X-RAY DIFFRACTION 0.203 0.166 False True IGHV9 IGKV12 Kappa None None None None None 7cwu J F 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5tdn D C 0 IMMUNE SYSTEM 09/19/16 Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces HOMO SAPIENS homo sapiens homo sapiens Yin, Y., Carter, P.J. 1.63 X-RAY DIFFRACTION 0.215 0.185 False True IGHV3 IGKV1 Kappa None None None None None 7t3d K N 0 F protein NA hemagglutinin ha1 chain Viral Protein/IMMUNE SYSTEM 12/07/21 CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA INFLUENZA A VIRUS (A/CALIFORNIA/04/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009(h1n1)) Han, J., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2wuc H L 0 A protein hepatocyte growth factor activator long chain HYDROLASE/HYDROLASE INHIBITOR 10/01/09 Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp and Ac-KQLR-chloromethylketone HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Ganesan, R., Eigenbrot, C., Shia, S., , 2.7 X-RAY DIFFRACTION 0.274 0.226 False True IGHV3 IGKV1 Kappa 1.61e-07 -9.26 SPR 25 20004165 6gci B NA 0 A protein mitochondrial adp/atp carrier MEMBRANE PROTEIN 04/17/18 Structure of the bongkrekic acid-inhibited mitochondrial ADP/ATP carrier THERMOTHELOMYCES THERMOPHILA (STRAIN ATCC 42464 / BCRC 31852 / DSM 1799); LAMA GLAMA lama glama thermothelomyces thermophila (strain atcc 42464/ bcrc 31852 / dsm 1799) Ruprecht, J.J., King, M.S., Pardon, E., Aleksandrova, A.A., Zogg, T., Crichton, P.G., Steyaert, J., Kunji, E.R.S. 3.3 X-RAY DIFFRACTION 0.283 0.252 False True IGHV1 None None None None None 4mxv H L 0 A protein lymphotoxin-alpha CYTOKINE/IMMUNE SYSTEM 09/26/13 Structure of Lymphotoxin alpha bound to anti-LTa Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, J.P., Hymowitz, S.G. 3.2 X-RAY DIFFRACTION 0.235 0.177 False True IGHV3 IGKV1 Kappa None None None None None 2p8m B A 0 C peptide gp41 peptide viral protein 03/22/07 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELLELDKWASLWN in new crystal form HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.P., Bryson, S., Pai, E.F. 2.7 X-RAY DIFFRACTION 0.238 0.223 False False IGHV2 IGKV1 Kappa None None None None None 7e5r I K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2aeq H L 0 A protein neuraminidase HYDROLASE/IMMUNE SYSTEM 07/23/05 An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex. INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Venkatramani, L., Bochkarev, A., Air, G.M. 3.0 X-RAY DIFFRACTION 0.312 0.267 False False IGHV7 IGKV6 Kappa 1.20e-08 -10.8 Other 16384583 3fo1 B A 0 B Hapten BZH 5-[(2-AMINO-1H-BENZIMIDAZOL-6-YL)AMINO]-5-OXOPENTANOIC ACID IMMUNE SYSTEM 12/27/08 Crystal structure of hapten complex of catalytic elimination antibody 13G5 (Glu(L39)Ala mutant) MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.281 0.225 False True IGHV2 IGKV1 Kappa None None None None None 6bzv E F 0 K peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.654 X-RAY DIFFRACTION 0.241 0.199 False True IGHV3 IGKV3 Kappa None None None None None 6mam C D 0 L | K protein | protein NA | NA envelope glycoprotein | envelope glycoprotein Viral protein/immune system 08/28/18 Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) | zaire ebolavirus (strain mayinga-76) West, B.R., Moyer, C.L., Fusco, M.L., Saphire, E.O. 4.1 X-RAY DIFFRACTION 0.281 0.262 False True IGHV3 IGKV1 Kappa None None None None None 7cwo H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 SARS-CoV-2 spike protein RBD and P17 fab complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6pz8 H L 0 B protein s protein VIRAL PROTEIN/IMMUNE SYSTEM 07/31/19 MERS S0 trimer in complex with variable domain of antibody G2 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Bowman, C.A., Pallesen, J., Ward, A.B. 4.19 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 3iu3 C D 0 J protein interleukin-2 receptor alpha chain IMMUNE SYSTEM 08/29/09 Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Du, J., Yang, H., Wang, J., Ding, J. 2.9 X-RAY DIFFRACTION 0.262 0.215 False True IGHV1 IGKV4 Kappa 1.40e-10 -13.44 SPR 25 20032294 4dka B NA 0 RNA BINDING PROTEIN/IMMUNE SYSTEM 02/03/12 Structure of Editosome protein LAMA GLAMA; TRYPANOSOMA BRUCEI lama Park, Y.-J., Hol, W. 1.97 X-RAY DIFFRACTION 0.229 0.187 False True IGHV1 None None None None None 6o9h H L 0 D protein ecd IMMUNE SYSTEM 03/13/19 Mouse ECD with Fab1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Min, X., Wang, Z. 2.1 X-RAY DIFFRACTION 0.248 0.203 False True IGHV5 IGKV8 Kappa None None None None None 6xsn H L 0 C peptide NA 16055_v1v2-1fd6 IMMUNE SYSTEM 07/15/20 Crystal structure of NHP VD20.5A4 Fab in complex with 16055 V1V2 1FD6 scaffold MACACA MULATTA macaca mulatta macaca mulatta macaca mulatta Aljedani, S., Pancera, M. 2.87 X-RAY DIFFRACTION 0.267 0.221 False False IGHV4 IGKV1 Kappa None None None None None 5gs1 F f 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 5icy B A 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with linear meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.5 X-RAY DIFFRACTION 0.206 0.160 False True IGHV2 IGKV5 Kappa 8.7e-06 -6.903730949189437 Unknown TBD 5dhv A B 0 N protein protein rev IMMUNE SYSTEM 08/31/15 HIV-1 Rev NTD dimers with variable crossing angles HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C. 2.3 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 IGKV1 Kappa None None None None None 7oap F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 04/19/21 Nanobody H3 AND C1 bound to RBD LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 Naismith, J.H., Mikolajek, H. 1.901 X-RAY DIFFRACTION 0.204 0.180 False False IGHV1 NA NA None None None None None 1moe A a 0 IMMUNE SYSTEM 09/09/02 The three-dimensional structure of an engineered scFv T84.66 dimer or diabody in VL to VH linkage. MUS MUSCULUS mus musculus Carmichael, J.A., Power, B.E., Garrett, T.P.J., Yazaki, P.J., Shively, J.E., Raubischek, A.A., Wu, A.M., Hudson, P.J. 2.6 X-RAY DIFFRACTION 0.300 0.213 True True unknown unknown unknown None None None None None 1sjv A NA 0 ANTIBIOTIC 03/04/04 Three-Dimensional Structure of a Llama VHH Domain Swapping LAMA GLAMA lama glama Spinelli, S., Desmyter, A., Frenken, L., Verrips, T., Cambillau, C. 1.94 X-RAY DIFFRACTION 0.225 0.206 False True IGHV1 None None None None None 5th9 J N 0 C protein matrix metalloproteinase-9,matrix metalloproteinase-9 hydrolase/hydrolase inhibitor 09/29/16 Structure determination of a potent, selective antibody inhibitor of human MMP9 (GS-5745 bound to MMP-9) ORYCTOLAGUS CUNICULUS; HOMO SAPIENS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Appleby, T.C., Greenstein, A.E., Kwon, H.J. 2.999 X-RAY DIFFRACTION 0.257 0.218 False True IGHV2 IGKV6 Kappa None None None None None 7rdw Q R 0 C protein NA glycoprotein 120 IMMUNE SYSTEM 07/12/21 Crystal Structure of FH1 Fab bound to HXb2 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Weidle, C., Pancera, M. 3.55 X-RAY DIFFRACTION 0.295 0.260 False True IGHV1 IGKV3 Kappa None None None None None 6mb3 J S 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7q9p J K 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-06 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4xbg C D 0 IMMUNE SYSTEM 12/16/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA): 2.73 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGKV3 Kappa None None None None None 3j70 A B 0 D protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/22/14 Model of gp120, including variable regions, in complex with CD4 and 17b HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Rasheed, M., Bettadapura, R., Bajaj, C. NOT ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 6ad8 E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148D mutant CLC-ec1 in 50 mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 3.3 X-RAY DIFFRACTION 0.284 0.227 False False IGHV4 IGKV4 Kappa None None None None None 7zmv F NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.002 X-RAY DIFFRACTION 0.275 0.242 False True IGHV1 NA NA None None None None None 6x1s H L 0 I peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC1-1) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 1.65 X-RAY DIFFRACTION 0.226 0.200 False True IGHV1 IGKV1 Kappa None None None None None 3mlw I M 0 Q peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 1006-15D in complex with an MN V3 peptide HIV-1 M:B_MN; HOMO SAPIENS homo sapiens homo sapiens hiv-1 m Kong, X.-P. 2.7 X-RAY DIFFRACTION 0.291 0.214 False False IGHV5 IGLV1 Lambda None None None None None 6mzj D C 0 B protein 426c ds-sosip d3 VIRAL PROTEIN/IMMUNE SYSTEM 11/05/18 Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 2 Fabs bound, sharpened map HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Borst, A.J., Weidle, C.E., Gray, M.D., Frenz, B., Snijder, J., Joyce, M.G., Georgiev, I.S., Stewart-Jones, G.B.E., Kwong, P.D., McGuire, A.T., DiMaio, F., Stamatatos, L., Pancera, M., Veesler, D. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 3gi9 H L 0 C protein uncharacterized protein mj0609 TRANSPORT PROTEIN 03/05/09 Crystal Structure of ApcT Transporter Bound to 7F11 Monoclonal Fab Fragment MUS MUSCULUS; METHANOCALDOCOCCUS JANNASCHII mus musculus mus musculus methanocaldococcus jannaschii Shaffer, P.L., Goehring, A.S., Shankaranarayanan, A., Gouaux, E., New York Consortium on Membrane Protein Structure (NYCOMPS) 2.48 X-RAY DIFFRACTION 0.296 0.248 False True IGHV1 IGKV8 Kappa None None None None None 5iq9 H L 0 P peptide gp41 mper peptide IMMUNE SYSTEM 03/10/16 Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Kwon, Y.D., Caruso, W., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.236 0.191 False True IGHV3 IGLV3 Lambda None None None None None 7f46 H L 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 06/17/21 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab (state1, local refinement of the RBD, NTD and 35B5 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 4.79 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 2gcy B A 0 IMMUNE SYSTEM 03/14/06 humanized antibody C25 Fab fragment MUS MUSCULUS mus musculus mus musculus LaPorte, S.L., Finer-Moore, J., Marks, J.D., Forsyth, C.M. 2.5 X-RAY DIFFRACTION 0.232 0.225 False True IGHV5 IGKV3 Kappa None None None None None 7e6p H L 0 A peptide NA amyloid beta fragment with an intramolecular disulfide bondat positions 17 and 28 IMMUNE SYSTEM 02/23/21 Fab-amyloid beta fragment complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Kita, A., Irie, K., Irie, Y., Miki, K. 2.5 X-RAY DIFFRACTION 0.244 0.191 False False IGHV1 IGKV8 Kappa None None None None None 4zg1 A NA 0 PROTEIN BINDING 04/22/15 Crystal structure of a nanobody raised against KDM5b LAMA GLAMA lama glama Wiuf, A., Kristensen, O., Gajhede, M. 1.85 X-RAY DIFFRACTION 0.235 0.186 False True IGHV1 None None None None None 6mi2 A B 0 C protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 09/19/18 Structure of the human 4-1BB / Utomilumab Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kimberlin, C.R., Chin, S.M., Roe-Zurz, Z., Xu, A., Yang, Y. 2.72 X-RAY DIFFRACTION 0.278 0.238 False True IGHV5 IGLV3 Lambda 6.900000000000001e-08 -9.769557801336566 SPR TBD 7jv5 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 08/20/20 Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Zhuang, Y., Xu, P., Mao, C., Wang, L., Krumm, B., Zhou, X.E., Huang, S., Liu, H., Cheng, X., Huang, X.-P., Sheng, D.-D., Xu, T., Liu, Y.-F., Wang, Y., Guo, J., Jiang, Y., Jiang, H., Melcher, K., Roth, B.L., Zhang, Y., Zhang, C., Xu, H.E. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7qji F NA 0 E protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.1 X-RAY DIFFRACTION 0.316 0.267 False True IGHV1 NA NA None None None None None 3eba A NA 0 B protein lysozyme c IMMUNE SYSTEM/HYDROLASE 08/27/08 CAbHul6 FGLW mutant (humanized) in complex with human lysozyme CAMELUS DROMEDARIUS; HOMO SAPIENS camelus dromedarius homo sapiens Loris, R., Vincke, C., Saerens, D., Martinez-Rodriguez, S., Muyldermans, S., Conrath, K. 1.85 X-RAY DIFFRACTION 0.255 0.211 False True IGHV1 2.36e-09 -11.76 SPR 19010777 5uoe H L 0 A protein insulin-degrading enzyme Hydrolase/Immune System 01/31/17 Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J. 3.8 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV1 Kappa None None None None None 7vui N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/02/21 Cryo-EM structure of a class A orphan GPCR HOMO SAPIENS; BACILLUS CIRCULANS homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Zhou, Y.L., Wu, L.J. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2qqk H L 0 A protein neuropilin-2 SIGNALING PROTEIN 07/26/07 Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Appleton, B.A., Wiesmann, C. 2.75 X-RAY DIFFRACTION 0.243 0.186 False True IGHV3 IGKV1D Kappa None None None None None 4m1d H L 0 P peptide cyclic v3 arch peptide IMMUNE SYSTEM 08/02/13 Crystal structure of anti-HIV-1 Fab 447-52D in complex with V3 cyclic peptide MN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Killikelly, A., Kong, X.P. 1.8 X-RAY DIFFRACTION 0.216 0.186 False True IGHV3 IGLV1 Lambda 2.3e-08 -10.420467653019871 Unknown TBD 4xph H L 0 A protein transporter protein transport/inhibitor 01/17/15 X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to 3,4dichlorophenethylamine MUS MUSCULUS; DROSOPHILA MELANOGASTER mus musculus mus musculus drosophila melanogaster Penmatsa, A., Wang, K., Gouaux, E. 2.9 X-RAY DIFFRACTION 0.277 0.240 False True IGHV5 IGKV4 Kappa None None None None None 7sob C B 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4r4n T U 0 S protein NA m48u1 peptide VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 7vsu B A 0 NA NA NA NA BIOSYNTHETIC PROTEIN 10/27/21 Crystal structure of Fab fragment of anti-mesothelin antibody HOMO SAPIENS homo sapiens homo sapiens Yang, Z., Ying, T. 3.1 X-RAY DIFFRACTION 0.249 0.215 False True IGHV4 IGKV1 Kappa None None None None None 3efd H L 0 K peptide kcsa IMMUNE SYSTEM 09/08/08 The crystal structure of the cytoplasmic domain of KcsA MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Uysal, S., Vasquez, V., Tereshko, V., Esaki, K., Fellouse, F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A. 2.6 X-RAY DIFFRACTION 0.276 0.225 False False IGHV3 IGKV1 Kappa None None None None None 3j8w G K 0 C protein NA l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 13 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV12 Kappa None None None None None 3rpi A B 0 IMMUNE SYSTEM 04/26/11 Crystal Structure of Fab from 3BNC60, Highly Potent anti-HIV Antibody HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Bjorkman, P.J. 2.648 X-RAY DIFFRACTION 0.258 0.208 False True IGHV1 IGKV1 Kappa None None None None None 7nc0 H L 0 NA NA NA NA IMMUNE SYSTEM 01/28/21 The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer HOMO SAPIENS homo sapiens homo sapiens Tang, J., Zhang, C., Dalby, P., Kozielski, F. 2.2 X-RAY DIFFRACTION 0.257 0.215 False True IGHV3 IGKV1 Kappa None None None None None 3be1 H L 0 A protein receptor tyrosine-protein kinase erbb-2 TRANSFERASE 11/15/07 Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bostrom, J.M., Wiesmann, C., Appleton, B.A. 2.9 X-RAY DIFFRACTION 0.277 0.236 False True IGHV3 IGKV1 Kappa 2.60e-08 -10.34 SPR 19299620 4zpv H L 0 R protein spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/15 Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2) HUMAN CORONAVIRUS EMC (ISOLATE UNITED KINGDOM/H123990006/2012); MUS MUSCULUS mus musculus mus musculus human coronavirus emc (isolate unitedkingdom/h123990006/2012) Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 3.2 X-RAY DIFFRACTION 0.281 0.223 False False IGHV5 IGKV10 Kappa None None None None None 6y97 H L 0 A | B protein | protein NA | NA b-lymphocyte antigen cd20 | b-lymphocyte antigen cd20 MEMBRANE PROTEIN 03/06/20 Structure of full-length CD20 in complex with Obinutuzumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Kumar, A., Reyes, N. 4.33 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 6xw6 C NA 0 A protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5853 MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 1.96 X-RAY DIFFRACTION 0.248 0.199 False True IGHV1 None None None None None 4grw I NA 0 D protein interleukin-12 subunit beta IMMUNE SYSTEM 08/27/12 Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) LLAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C. 2.55 X-RAY DIFFRACTION 0.218 0.183 False True IGHV1 None None None None None 7e9n H L 0 A protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/04/21 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 6war L NA 0 K protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 4grw J NA 0 A protein interleukin-23 subunit alpha IMMUNE SYSTEM 08/27/12 Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) LLAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C. 2.55 X-RAY DIFFRACTION 0.218 0.183 False True IGHV1 None None None None None 5dmg C D 0 Z peptide microtubule-associated protein IMMUNE SYSTEM 09/08/15 X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430) ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Benz, J., Lorenz, S., Georges, G., Jochner, A., Goepfert, U., Grueninger, F., Bujotzek, A. 2.5 X-RAY DIFFRACTION 0.263 0.210 False True IGHV1 IGKV1 Kappa None None None None None 6e5p R Q 0 R carbohydrate NAG polysaccharide VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens homo sapiens Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7lf7 H L 0 K protein NA apolipoprotein l1 IMMUNE SYSTEM 01/15/21 Fab 6D12 bound to ApoL1 NTD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Kirchhofer, D. 2.026 X-RAY DIFFRACTION 0.217 0.189 False True IGHV5 IGKV16 Kappa None None None None None 5vxm B NA 0 A protein invasin ipad IMMUNE SYSTEM 05/23/17 2.05 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody 20ipaD SHIGELLA FLEXNERI; VICUGNA PACOS vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.05 X-RAY DIFFRACTION 0.246 0.210 False True IGHV1 None None None None None 6vy4 H L 0 A protein NA receptor binding protein VIRAL PROTEIN/IMMUNE SYSTEM 02/25/20 Crystal structure of Hendra receptor binding protein head domain in complex with human neutralizing antibody HENV-32 HENDRA HENIPAVIRUS; HOMO SAPIENS homo sapiens homo sapiens hendra henipavirus Dong, J., Crowe, J.E. 2.0 X-RAY DIFFRACTION 0.226 0.183 False True IGHV1 IGLV3 Lambda None None None None None 1r3i H L 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 10/02/03 potassium channel KcsA-Fab complex in Rb+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y., MacKinnon, R. 2.4 X-RAY DIFFRACTION 0.236 0.217 False False IGHV1 IGKV5 Kappa None None None None None 7wd7 a b 0 A protein NA heavy chain of s5d2 fab VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with three S5D2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 5vm6 A NA 0 A Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/26/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T10 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.5 X-RAY DIFFRACTION 0.193 0.172 False True unknown unknown unknown None None None None None 5esz H L 0 G protein 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase,envelope glycoprotein gp160 IMMUNE SYSTEM 11/17/15 Crystal Structure of Broadly Neutralizing Antibody CH04, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade AE Strain A244 HOMO SAPIENS; HAEMOPHILUS INFLUENZAE homo sapiens homo sapiens haemophilus influenzae, human immunodeficiencyvirus 1, haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd) Gorman, J., Yang, M., Kwong, P.D. 4.191 X-RAY DIFFRACTION 0.282 0.252 False True IGHV3 IGKV3 Kappa None None None None None 3ria G K 0 C protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.8 X-RAY DIFFRACTION 0.280 0.266 False True IGHV1 IGLV1 Lambda None None None None None 7p5y G NA 0 A protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7lyw A B 0 NA NA NA NA IMMUNE SYSTEM 03/08/21 Crystal structure of the HCMV pentamer-specific antibody 2-25 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., Mishra, A.K., McLellan, J.S. 2.51 X-RAY DIFFRACTION 0.219 0.187 False True IGHV1 IGLV3 Lambda None None None None None 1wtl NA A 0 IMMUNOGLOBULIN 06/08/94 COMPARISON OF CRYSTAL STRUCTURES OF TWO HOMOLOGOUS PROTEINS: STRUCTURAL ORIGIN OF ALTERED DOMAIN INTERACTIONS IN IMMUNOGLOBULIN LIGHT CHAIN DIMERS HOMO SAPIENS homo sapiens Huang, D.B., Chang, C.H., Schiffer, M. 1.9 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 5jds B NA 0 A protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 04/17/16 Crystal structure of PD-L1 complexed with a nanobody at 1.7 Angstron resolution CAMELIDAE; HOMO SAPIENS camelidae homo sapiens Zhou, A., Wei, H. 1.7 X-RAY DIFFRACTION 0.204 0.178 False True IGHV1 3.0000000000000004e-09 -11.627286953008985 SPR TBD 2mmx NA A 16 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 7k7i H L 0 A protein NA putative pertussis-like toxin subunit TOXIN 09/22/20 Density-fitted Model Structure of Antibody Variable Domains of TyTx4 in Complex with PltB pentamer of Typhoid Toxin SALMONELLA TYPHI; MUS MUSCULUS mus musculus mus musculus salmonella typhi Nguyen, T., Feathers, J.R., Fromme, J.C., Song, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 1wcb B A 0 IMMUNE SYSTEM 11/12/04 PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH ITS HAPTEN MUS MUSCULUS mus musculus mus musculus Pimpaneau, Beatrice Golinelli-, Christen, P. 2.5 X-RAY DIFFRACTION 0.2899 0.2230 False True IGHV7 IGKV4 Kappa None None None None None 2qr0 N M 0 O protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 3s96 C D 0 IMMUNE SYSTEM 05/31/11 Crystal structure of 3B5H10 MUS MUSCULUS mus musculus mus musculus Weisgraber, K., Peters-Libeu, C., Rutenber, E., Newhouse, Y., Finkbeiner, S. 1.9 X-RAY DIFFRACTION 0.260 0.183 False False IGHV9 IGLV3 Lambda None None None None None 1mfb H L 0 H carbohydrate GLA polysaccharide IMMUNOGLOBULIN 10/25/93 HIGH RESOLUTION STRUCTURES OF ANTIBODY FAB FRAGMENT COMPLEXED WITH CELL-SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA MUS MUSCULUS mus musculus mus musculus mus musculus Zdanov, A., Cygler, M. 2.1 X-RAY DIFFRACTION unknown 0.160 False True IGHV1 IGLV1 Lambda None None None None None 7mfg E F 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 04/09/21 Cryo-EM structure of the VRC310 clinical trial, vaccine-elicited, human antibody 310-030-1D06 Fab in complex with an H1 NC99 HA trimer INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6pcu I H 0 G protein outer capsid protein vp4 viral protein/immune system 06/18/19 VP8* of a G2P[4] human rotavirus in complex with scFv antibody 9 ROTAVIRUS A; HOMO SAPIENS homo sapiens homo sapiens rotavirus a Hu, L., Venkataram Prasad, B.V. 2.4 X-RAY DIFFRACTION 0.237 0.186 False True IGHV4 IGLV9 Lambda None None None None None 6n81 C D 0 B protein major capsid protein IMMUNE SYSTEM 11/28/18 Crystal structure of GII.4 2002 norovirus P domain in complex with cross-reactive human antibody A1227 NOROVIRUS HU/GII.4/FARMINGTON HILLS/2004/USA; HOMO SAPIENS homo sapiens homo sapiens norovirus hu/gii.4/farmington hills/2004/usa Changela, A., Verardi, R., Kwong, P.D. 2.579 X-RAY DIFFRACTION 0.211 0.173 False True IGHV3 IGKV1 Kappa None None None None None 1bww NA A 0 IMMUNE SYSTEM 09/29/98 BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT HOMO SAPIENS homo sapiens Uson, I., Pohl, E., Schneider, T.R., Dauter, Z., Schmidt, A., Fritz, H.J., Sheldrick, G.M. 1.7 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 1hzh H L 0 IMMUNE SYSTEM 01/24/01 CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN HOMO SAPIENS homo sapiens homo sapiens Saphire, E.O., Burton, D.R., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.273 0.229 False True IGHV1 IGKV3 Kappa None None None None None 4zpv A B 0 S protein spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/15 Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2) HUMAN CORONAVIRUS EMC (ISOLATE UNITED KINGDOM/H123990006/2012); MUS MUSCULUS mus musculus mus musculus human coronavirus emc (isolate unitedkingdom/h123990006/2012) Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 3.2 X-RAY DIFFRACTION 0.281 0.223 False False IGHV5 IGKV10 Kappa None None None None None 1f8t H L 0 IMMUNE SYSTEM 07/05/00 FAB (LNKB-2) OF MONOCLONAL ANTIBODY, CRYSTAL STRUCTURE MUS MUSCULUS mus musculus mus musculus Fokin, A.V., Afonin, P.V., Mikhailova, I.I., Tsygannik, I.N., Mareeva, T.I. 2.2 X-RAY DIFFRACTION 0.221 0.171 False False IGHV3 IGKV1 Kappa None None None None None 7wec G J 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein with three XGv347 Fabs binding to three closed state RBDs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4r7n K L 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 6iw2 B C 0 A protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state YELLOW FEVER VIRUS (STRAIN 17D VACCINE); HOMO SAPIENS homo sapiens homo sapiens yellow fever virus (strain 17d vaccine) Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 2.9 X-RAY DIFFRACTION 0.272 0.238 False True IGHV4 IGKV1 Kappa None None None None None 2qtj C O 3 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7djy A NA 0 NA NA NA NA BIOSYNTHETIC PROTEIN 11/22/20 Clec4f Nanobody 322 LAMIUM MACULATUM lamium maculatum Wen, Y., Zheng, F. 2.7 X-RAY DIFFRACTION 0.266 0.228 False True IGHV1 NA NA None None None None None 3ntc H L 0 IMMUNE SYSTEM 07/03/10 Crystal structure of KD-247 Fab, an anti-V3 antibody that inhibits HIV-1 Entry HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Sarafianos, S.G., Kirby, K.A. 1.55 X-RAY DIFFRACTION 0.222 0.182 False True IGHV1 IGKV8 Kappa None None None None None 6woz H I 0 G protein NA reticulocyte binding protein 2b CELL INVASION 04/26/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 251249 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.258 0.211 False True IGHV3 IGKV3 Kappa None None None None None 1ce1 H L 0 P peptide protein (peptide antigen) IMMUNE SYSTEM 03/12/99 1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN HOMO SAPIENS; SYNTHETIC CONSTRUCT James, L.C., Hale, G., Waldmann, H., Bloomer, A.C. 1.9 X-RAY DIFFRACTION 0.270 0.220 False True IGHV4 IGKV1 Kappa None None None None None 4wht X Y 0 x peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 3ze0 E F 0 C protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.95 X-RAY DIFFRACTION 0.2427 0.1847 False True IGHV14 IGKV14 Kappa None None None None None 7ey0 A B 0 R protein NA spike glycoprotein VIRAL PROTEIN 05/29/21 Local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-813 Fab and BD-744 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6q19 H L 0 IMMUNE SYSTEM 08/03/19 Inferred intermediate (I-6) of the human antibody lineage 652 HOMO SAPIENS homo sapiens homo sapiens McCarthy, K.R., Harrison, S.C. 1.58 X-RAY DIFFRACTION 0.191 0.164 False True IGHV4 IGLV3 Lambda None None None None None 3mls H L 0 P peptide rationally designed v3 mimotope IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.-P. 2.5 X-RAY DIFFRACTION 0.274 0.216 False False IGHV5 IGLV3 Lambda None None None None None 1axt H L 0 IMMUNOGLOBULIN 10/20/97 IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES MUS MUSCULUS mus musculus mus musculus Heine, A., Wilson, I.A. 2.15 X-RAY DIFFRACTION unknown unknown False False IGHV6 IGKV1 Kappa None None None None None 7nqk B NA 0 A protein NA solute carrier family 15 member 2 MEMBRANE PROTEIN 03/01/21 Cryo-EM structure of the mammalian peptide transporter PepT2 RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Parker, J.L., Deme, J.C., Lea, S.M., Newstead, S. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 6umj H L 0 H Hapten BU2 1,3-BUTANEDIOL IMMUNE SYSTEM 10/09/19 Crystal structure of erenumab Fab-c HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mohr, C. 2.7 X-RAY DIFFRACTION 0.267 0.225 False True IGHV3 IGLV1 Lambda None None None None None 5od8 A B 0 IMMUNE SYSTEM 07/05/17 Crystal structure of the RA-associated mAb B2 (Fab fragment) HOMO SAPIENS homo sapiens homo sapiens Dobritzsch, D., Ge, C., Holmdahl, R., Amara, K., Malmstrom, V. 2.2 X-RAY DIFFRACTION 0.243 0.200 False True IGHV1 IGKV1 Kappa None None None None None 7vgx S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/19/21 Neuropeptide Y Y1 Receptor (NPY1R) in Complex with G Protein and its endogeneous Peptide-Agonist Neuropeptide Y (NPY) HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Park, C., Kim, J., Jeong, H., Kang, H., Bang, I., Choi, H.-J. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7kde O P 0 G | B protein | protein NA | NA envelope glycoprotein gp120 | hiv-1 envelope glycoprotein bg505 sosip.664 gp41 VIRAL PROTEIN/Immune System 10/08/20 BG505 SOSIP.664 in complex with the V3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 3ls5 H L 0 IMMUNE SYSTEM 02/12/10 Anti-tetrahydrocannabinol Fab Fragment, Free Form MUS MUSCULUS mus musculus mus musculus Niemi, M.H., Rouvinen, J. 1.9 X-RAY DIFFRACTION 0.243 0.214 False True IGHV5 IGKV4 Kappa None None None None None 7mlu G J 0 B protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 6swr A NA 0 TRANSPORT PROTEIN 09/23/19 Crystal structure of the lysosomal potassium channel MtTMEM175 T38A mutant soaked with zinc LAMA GLAMA; ESCHERICHIA COLI (STRAIN K12); MARIVIRGA TRACTUOSA (STRAIN ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) lama glama, escherichia coli (strain k12) Brunner, J.D., Jakob, R.P., Schulze, T., Neldner, Y., Moroni, A., Thiel, G., Maier, T., Schenck, S. 3.2 X-RAY DIFFRACTION 0.299 0.269 False True IGHV1 None None None None None 6e9q A B 0 IMMUNE SYSTEM 05/01/19 The crystal structure of bovine ultralong antibody BOV-6 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.4 X-RAY DIFFRACTION 0.311 0.254 False True IGHV1 IGLV1 Lambda None None None None None 2xra H L 0 A protein transmembrane protein gp41 IMMUNE SYSTEM 09/13/10 crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix SYNTHETIC CONSTRUCT; HOMO SAPIENS homo sapiens homo sapiens synthetic construct Sabin, C., Corti, D., Buzon, V., Seaman, M.S., Lutje-Hulsik, D., Hinz, A., Vanzetta, F., Agatic, G., Silacci, C., Langedijk, J.P.M., Mainetti, L., Scarlatti, G., Sallusto, F., Weiss, R., Lanzavecchia, A., Weissenhorn, W. 2.3 X-RAY DIFFRACTION 0.27943 0.23693 False False IGHV1 IGKV1 Kappa 3.30e-09 -11.56 SPR 25 21124990 3sqo H L 0 A protein proprotein convertase subtilisin/kexin type 9 HYDROLASE/Immune system 07/05/11 PCSK9 J16 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Strop, P. 2.7 X-RAY DIFFRACTION 0.283 0.223 False True IGHV1 IGKV1D Kappa 5e-12 -15.417363375832577 SPR TBD 7z1a B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.59 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 5wux H L 0 E protein tumor necrosis factor alpha IMMUNE SYSTEM 12/21/16 TNFalpha-certolizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, J.U. 2.9 X-RAY DIFFRACTION 0.266 0.226 False True IGHV3 IGKV1 Kappa 2.7399999999999997e-11 -14.40948636554907 SPR TBD 2fed E F 0 B protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 12/15/05 Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C. 3.317 X-RAY DIFFRACTION 0.287 0.248 False True IGHV3 IGKV6D Kappa None None None None None 7lxy E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2X333 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7lk4 B A 0 R protein NA bcl-2 homologous antagonist/killer APOPTOSIS 02/01/21 Crystal structure of BAK L100A in complex with activating antibody fragments HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Robin, Y.A., Colman, P.M. 3.1 X-RAY DIFFRACTION 0.262 0.214 False True IGHV5 IGKV16 Kappa None None None None None 6oyz H NA 0 D protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to capuramycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.62 X-RAY DIFFRACTION 0.301 0.277 False True IGHV1 None None None None None 5w23 J N 0 A protein fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/17 Crystal Structure of RSV F in complex with 5C4 Fab HUMAN RESPIRATORY SYNCYTIAL VIRUS A; MUS MUSCULUS mus musculus mus musculus human respiratory syncytial virus a Battles, M.B., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.239 0.198 False True IGHV14 IGKV3 Kappa None None None None None 7kmh A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/02/20 LY-CoV488 neutralizing antibody against SARS-CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hendle, J., Pustilnik, A., Sauder, J.M., Boyles, J.S., Dickinson, C.D., Coleman, K.A. 1.72 X-RAY DIFFRACTION 0.242 0.194 False True IGHV3 IGKV1 Kappa None None None None None 4xnm B A 0 D protein hemagglutinin Viral protein/Immune system 01/15/15 Antibody Influenza H5 Complex HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Winarski, K.L., Spiler, B.W. 2.51 X-RAY DIFFRACTION 0.241 0.214 False True IGHV4 IGLV3 Lambda 8e-09 -11.046161627732946 SPR TBD 6axk A B 0 E peptide ace-asn-pro-asn-ala-asn-pro-asn-ala-asn-pro-asn IMMUNE SYSTEM 09/07/17 Crystal structure of Fab311 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Oyen, D., Wilson, I.A. 2.103 X-RAY DIFFRACTION 0.236 0.204 False True IGHV3 IGLV1 Lambda 3.05e-07 -8.889005432540593 Unknown TBD 7nx6 H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.25 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGKV1 Kappa None None None None None 7wka a b 0 B protein NA light chain of s3h3 fab VIRAL PROTEIN 01/08/22 SARS-CoV-2 Omicron closed state spike protein in complex with S3H3 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 3.64 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 6svl D E 0 F protein myeloid-derived growth factor CYTOKINE 09/18/19 human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ebenhoch, R., Nar, H. 1.58 X-RAY DIFFRACTION 0.206 0.181 False True IGHV14 IGKV12 Kappa None None None None None 7x7e A NA 0 D protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 SARS-CoV-2 RBD and Nb22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA lama severe acute respiratory syndrome coronavirus2 Wang, Y., Ye, S. 2.67 X-RAY DIFFRACTION 0.250 0.205 False True IGHV1 NA NA None None None None None 5hm1 C NA 0 F peptide gp41 IMMUNE SYSTEM 01/15/16 Llama VHH 2E7 in complex with gp41 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama hiv-1 m Hock, M., Caillat, C., Haffke, M., Weissenhorn, W. 2.962 X-RAY DIFFRACTION 0.249 0.194 False True IGHV1 None None None None None 7rbt N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/06/21 cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.08 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4m93 H L 0 IMMUNE SYSTEM 08/14/13 Unliganded 2 crystal structure of S25-26 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.09 X-RAY DIFFRACTION 0.251 0.218 False False IGHV2 IGKV1 Kappa None None None None None 5d1x B A 0 E protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT2 bound by D4-30 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN USA300) homo sapiens homo sapiens staphylococcus aureus (strain usa300) Deng, X. 3.21 X-RAY DIFFRACTION 0.310 0.269 False True unknown IGKV2 Kappa 2.1e-11 -14.567099215178107 SPR TBD 7r63 C NA 0 NA NA NA NA IMMUNE SYSTEM 06/22/21 Nb82, a nanobody against voltage gated sodium channels Nav1.4 and Nav1.5 LAMA GLAMA lama glama Srinivasan, L., Gabelli, S.B. 2.0 X-RAY DIFFRACTION 0.244 0.184 False True IGHV1 NA NA None None None None None 7a5r H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/21/20 Complex of SARS-CoV-2 spike and CR3022 Fab (Non-Uniform Refinement) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 1fbi Q P 0 Y protein guinea fowl lysozyme COMPLEX (ANTIBODY/ANTIGEN) 01/19/95 CRYSTAL STRUCTURE OF A CROSS-REACTION COMPLEX BETWEEN FAB F9.13.7 AND GUINEA-FOWL LYSOZYME MUS MUSCULUS; NUMIDA MELEAGRIS mus musculus mus musculus numida meleagris Lescar, J., Alzari, P.M. 3.0 X-RAY DIFFRACTION unknown 0.190 False True IGHV1 IGKV10 Kappa None None None None None 6v7z E NA 0 C | D protein | protein NA | NA antigen-presenting glycoprotein cd1d | beta-2-microglobulin IMMUNE SYSTEM 12/10/19 Human CD1d presenting alpha-Galactosylceramide in complex with VHH nanobody 1D22 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Shahine, A., Rossjohn, J. 2.75 X-RAY DIFFRACTION 0.252 0.186 False True IGHV1 NA NA None None None None None 3j30 H G 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab CHK152 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 2jk5 A B 0 C protein voltage-gated potassium channel IMMUNE SYSTEM/METAL TRANSPORT 08/15/08 Potassium Channel KcsA in complex with Tetrabutylammonium in high K MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Lenaeus, M.J., Focia, P.J., Wagner, T., Gross, A. 2.4 X-RAY DIFFRACTION 0.249 0.202 False True IGHV1 IGKV5 Kappa None None None None None 7f3q C B 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/16/21 SARS-CoV-2 RBD in complex with A5-10 Fab and A34-2 Fab Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dou, Y., Wang, X., Liu, P., Lu, B., Wang, K. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6zxn E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/30/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3h0t B A 0 C peptide hepcidin IMMUNE SYSTEM/Antimicrobial Protein 04/10/09 Hepcidin-Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Syed, R., Li, V. 1.89 X-RAY DIFFRACTION 0.251 0.202 False True IGHV6 IGLV6 Lambda None None None None None 6p65 H L 0 A protein hiv env 16055 nfl td 2cc+ VIRAL PROTEIN/immune system 05/31/19 HIV Env 16055 NFL TD 2CC+ in complex with antibody 1C2 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.94 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 1g9e A NA 7 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7kzc H L 0 NA NA NA NA IMMUNE SYSTEM 12/10/20 Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies HOMO SAPIENS homo sapiens homo sapiens Langley, D.B., Christ, D. 2.3 X-RAY DIFFRACTION 0.257 0.212 False True IGHV1 IGLV3 Lambda None None None None None 6vlr D K 0 H protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/24/20 BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 4.42 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 4ubd K L 0 J | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 08/12/14 Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Shore, D.A., Yang, H., Cho, M., Donis, R.O., Stevens, J. 3.5 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 IGKV3 Kappa None None None None None 6mee C D 0 IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 1.36 X-RAY DIFFRACTION 0.191 0.167 False True IGHV1 IGKV1 Kappa None None None None None 4jkp H L 0 G protein gp120 viral protein/immune system 03/11/13 Restricting HIV-1 Pathways for Escape using Rationally-Designed Anti-HIV-1 Antibodies HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Diskin, R., Bjorkman, P.J. 2.82 X-RAY DIFFRACTION 0.231 0.193 False True unknown IGKV3 Kappa 5.1e-08 -9.94865428469745 SPR TBD 3vfg H L 0 IMMUNE SYSTEM 01/09/12 Crystal structure of monoclonal anitbody 3F8 Fab fragment that binds to GD2 ganglioside MUS MUSCULUS mus musculus mus musculus Ahmed, M., Goldgur, Y., Cheung, N.-K. 1.65 X-RAY DIFFRACTION 0.225 0.176 False True IGHV2 IGKV6 Kappa None None None None None 4qo1 A NA 0 B protein cellular tumor antigen p53 Apoptosis, transcription 06/19/14 p53 DNA binding domain in complex with Nb139 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens De Gieter, S., Bethuyne, J., Gettemans, J., Garcia-Pino, A., Loris, R. 1.924 X-RAY DIFFRACTION 0.205 0.165 False True IGHV1 None None None None None 6nfn F E 0 E Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 4xbe H L 0 P peptide peptide fragment of hiv glycoprotein (gp41) including theregion 671-683 of the mper IMMUNE SYSTEM 12/16/14 Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41: crystals cryoprotected with sphingomyelin (02:0 SM (d18:1/2:0)). HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Stanfield, R.L., Wilson, I.A. 1.756 X-RAY DIFFRACTION 0.197 0.150 False True IGHV1 IGKV3 Kappa None None None None None 4hwe H L 0 IMMUNE SYSTEM 11/07/12 Crystal structure of ectodomain 3 of the IL-13 receptor alpha1 in complex with a human neutralizing monoclonal antibody fragment HOMO SAPIENS homo sapiens homo sapiens Xu, Y. 2.43 X-RAY DIFFRACTION 0.223 0.175 False True IGHV5 IGKV3 Kappa None None None None None 7teq H L 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 active conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 7.51 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 6ele H L 0 IMMUNE SYSTEM 09/28/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 1.78 X-RAY DIFFRACTION 0.218 0.190 False True IGHV4 IGKV1 Kappa None None None None None 6cxg M K 0 C peptide 10v1s glycopeptide IMMUNE SYSTEM 04/03/18 anti-HIV-1 Fab 2G12 in complex with glycopeptide 10V1S HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Stanfield, R.L., Wilson, I.A. 2.298 X-RAY DIFFRACTION 0.237 0.197 False True unknown IGKV1 Kappa None None None None None 2kh2 B b 14 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5gs0 D C 0 A protein toll-like receptor 3 IMMUNE SYSTEM 08/13/16 Crystal structure of the complex of TLR3 and bi-specific diabody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 3.275 X-RAY DIFFRACTION 0.248 0.192 False True IGHV6 IGLV3 Lambda None None None None None 2ny5 H L 0 G protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.255 0.198 False True IGHV1 IGKV3 Kappa 3.19e-07 SPR 17301785 4zpt H L 0 S protein spike glycoprotein Viral protein/Immune system 05/08/15 Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 1) HUMAN CORONAVIRUS EMC (ISOLATE UNITED KINGDOM/H123990006/2012); MUS MUSCULUS mus musculus mus musculus human coronavirus emc (isolate unitedkingdom/h123990006/2012) Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 2.591 X-RAY DIFFRACTION 0.244 0.204 False False IGHV5 IGKV10 Kappa 9.93e-09 -10.91811468499047 BLI TBD 5gzn C D 0 B | G protein | protein NA | NA genome polyprotein | genome polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/16 Structure of neutralizing antibody bound to Zika envelope protein ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus | zika virus Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F. 3.0 X-RAY DIFFRACTION 0.258 0.223 False True IGHV3 IGLV1 Lambda None None None None None 5gs0 F E 0 B protein toll-like receptor 3 IMMUNE SYSTEM 08/13/16 Crystal structure of the complex of TLR3 and bi-specific diabody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 3.275 X-RAY DIFFRACTION 0.248 0.192 False True IGHV6 IGLV3 Lambda None None None None None 2ypv H L 0 A protein lipoprotein IMMUNE SYSTEM 11/01/12 Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody NEISSERIA MENINGITIDIS MC58; MUS MUSCULUS mus musculus mus musculus neisseria meningitidis mc58 Malito, E., Veggi, D., Bottomley, M.J. 1.8 X-RAY DIFFRACTION 0.2246 0.1812 False False IGHV1 IGKV14 Kappa 3e-11 -14.355775131829494 SPR TBD 4llw C D 0 IMMUNE SYSTEM 07/09/13 Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A HOMO SAPIENS homo sapiens homo sapiens Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S. 1.95 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 5if0 A B 0 I protein germline-targeting hiv-1 gp120 engineered outer domain eod-gt8 IMMUNE SYSTEM/VIRAL PROTEIN 02/25/16 Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.44 A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sarkar, A., Wilson, I.A. 2.44 X-RAY DIFFRACTION 0.232 0.191 False True IGHV1 IGKV4 Kappa None None None None None 5iie H L 0 IMMUNE SYSTEM 03/01/16 STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 HOMO SAPIENS homo sapiens homo sapiens Nicely, N.I., Haynes, B.F. 2.8 X-RAY DIFFRACTION 0.273 0.206 False True IGHV2 IGLV1 Lambda None None None None None 4xgz S T 0 s peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 7a0w E F 0 B protein NA na(+)/h(+) antiporter nhaa MEMBRANE PROTEIN 08/11/20 Structure of dimeric sodium proton antiporter NhaA, at pH 8.5, crystallized with chimeric Fab antibodies SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM STR. LT2; GALLUS GALLUS; HOMO SAPIENS gallus gallus, homo sapiens gallus gallus, homo sapiens salmonella enterica subsp. enterica serovartyphimurium str. lt2 Fippel, A., Gross, N.M., Mir, S.H., Wirth, C., Hunte, C. 2.04 X-RAY DIFFRACTION 0.235 0.198 False True unknown unknown unknown None None None None None 5ezl A B 0 IMMUNE SYSTEM 11/26/15 Crystal Structure of Fab c12 MUS MUSCULUS mus musculus mus musculus Favuzza, P., Pluschke, G., Rudolph, M.G. 2.43 X-RAY DIFFRACTION 0.245 0.187 False True IGHV4 IGKV6 Kappa None None None None None 7ns6 O NA 0 N protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/05/21 SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4 vicugna pacos severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Das, H., Hallberg, B.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6pk8 D d 0 NA NA NA NA IMMUNE SYSTEM 06/28/19 Antibody scFv-M204 dimeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 2.91 X-RAY DIFFRACTION 0.238 0.186 True True unknown unknown unknown None None None None None 6tyl I NA 0 F protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 08/09/19 Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., McClelland, L., Yates-Hansen, C., Sprang, S.R. 3.3 X-RAY DIFFRACTION 0.287 0.248 False True IGHV1 None None None None None 7pgb a b 0 d protein NA unknown MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False False IGHV3 IGKV1 Kappa None None None None None 6avq H L 0 B | A protein | protein NA | NA integrin beta-3 | integrin alpha-v SIGNALING PROTEIN 09/04/17 The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D. 35 ELECTRON MICROSCOPY False True IGHV5 IGKV5 Kappa None None None None None 2w9d H L 0 IMMUNE SYSTEM 01/23/09 Structure of Fab fragment of the ICSM 18 - anti-Prp therapeutic antibody at 1.65 A resolution. MUS MUSCULUS mus musculus mus musculus Antonyuk, S.V., Trevitt, C.R., Strange, R.W., Jackson, G.S., Sangar, D., Batchelor, M., Jones, S., Georgiou, T., Cooper, S., Fraser, C., Khalili-Shirazi, A., Clarke, A.R., Hasnain, S.S., Collinge, J. 1.57 X-RAY DIFFRACTION 0.217 0.184 False False IGHV1 IGKV4 Kappa None None None None None 7nkc F NA 0 NA NA NA NA VIRAL PROTEIN 02/17/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207 INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.46 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4etq A B 0 X protein imv membrane protein IMMUNE SYSTEM/VIRAL PROTEIN 04/24/12 Vaccinia virus D8L IMV envelope protein in complex with Fab of murine IgG2a LA5 MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus Matho, M.H., Zajonc, D.M. 2.1 X-RAY DIFFRACTION 0.252 0.202 False True IGHV1 IGKV4 Kappa 1.8e-10 -13.29418688782641 SPR TBD 5i1a H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV3-11 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.0 X-RAY DIFFRACTION 0.255 0.206 False True IGHV3 IGKV3 Kappa None None None None None 6h3u H L 0 B protein envelopment polyprotein VIRAL PROTEIN 07/19/18 Schmallenberg Virus Glycoprotein Gc Head Domain in Complex with scFv 4B6 MUS MUSCULUS; BOVINE SCHMALLENBERG VIRUS mus musculus mus musculus bovine schmallenberg virus Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A. 3.168 X-RAY DIFFRACTION 0.228 0.200 False True IGHV3 IGKV10 Kappa None None None None None 7kpb H L 0 A | C protein | protein NA | NA tumor necrosis factor | tumor necrosis factor CYTOKINE/Immune System 11/10/20 asymmetric hTNF-alpha HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Fox III, D., Conrady, D.G., Lowe, M., Ceska, T. 3.0 X-RAY DIFFRACTION 0.256 0.223 False True IGHV5 IGKV12 Kappa None None None None None 3naa H L 0 IMMUNE SYSTEM 06/01/10 Crystal structure of Fab15 Mut5 HOMO SAPIENS homo sapiens homo sapiens Luo, J., Feng, Y., Gilliland, G.L. 1.7 X-RAY DIFFRACTION 0.200 0.178 False True IGHV5 IGKV1 Kappa None None None None None 5vm0 A NA 0 A Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/26/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T9 LAMA GLAMA lama glama lama glama Wogulis, L.A., Wogulis, M.D., Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.79 X-RAY DIFFRACTION 0.242 0.204 False True IGHV1 1.6000000000000003e-09 -11.99972732482342 Unknown TBD 6rlm O P 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 4aix NA D 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rC34Y, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.8 X-RAY DIFFRACTION 0.2119 0.1684 False True IGLV3 Lambda None None None None None 7dq7 H L 0 B protein NA vp2 VIRUS/IMMUNE SYSTEM 12/22/20 Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 5F5 COXSACKIEVIRUS B1; MUS MUSCULUS mus musculus mus musculus coxsackievirus b1 Li, S., Zhu, R., Xu, L., Cheng, T., Zheng, Q. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 7eyc A B 0 Q peptide NA acetylated tau peptide IMMUNE SYSTEM 05/30/21 Crystal structure of Tau and acetylated tau peptide antigen MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Hong, M., Park, J. 2.49 X-RAY DIFFRACTION 0.245 0.192 False True IGHV4 IGKV1 Kappa None None None None None 5gry A a 0 IMMUNE SYSTEM 08/12/16 Crystal structure of disulfide-bonded diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 1.639 X-RAY DIFFRACTION 0.231 0.198 True True unknown unknown unknown None None None None None 7xic H I 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/22 S-ECD (Omicron) in complex with STS165 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Y.N., Shen, Y.P., Zhang, Y.Y., Yan, R.H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 1gc1 H L 0 G protein envelope protein gp120 VIRAL PROTEIN/RECEPTOR/IMMUNE SYSTEM 06/15/98 HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kwong, P.D., Wyatt, R., Robinson, J., Sweet, R.W., Sodroski, J., Hendrickson, W.A. 2.5 X-RAY DIFFRACTION 0.302 0.210 False True IGHV1 IGKV3 Kappa None None None None None 3fo0 H L 0 IMMUNE SYSTEM 12/27/08 Crystal structure of hapten complex of catalytic elimination antibody 13G5 (wild-type) MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.277 0.219 False True IGHV2 IGKV1 Kappa None None None None None 3zdz E F 0 C protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.75 X-RAY DIFFRACTION 0.2211 0.1844 False True IGHV14 IGKV14 Kappa None None None None None 2kqm NA B 6 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5o8f N NA 0 I | D carbohydrate | protein NAG | NA N-ACETYL-D-GLUCOSAMINE | gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 06/13/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.2 X-RAY DIFFRACTION 0.242 0.232 False True IGHV1 NA NA None None None None None 4ouu H L 0 HYDROLASE 02/19/14 anti-MT1-MMP monoclonal antibody MUS MUSCULUS mus musculus mus musculus Udi, Y., Grossman, M., Solomonov, I., Dym, O., Rozenberg, H., Koziol, A., Cuniasse, P., Dive, V., Arroyo, A.G., Irit, S., Israel Structural Proteomics Center (ISPC) 2.6 X-RAY DIFFRACTION 0.253 0.197 False True IGHV5 IGKV1 Kappa None None None None None 6e9u A B 0 IMMUNE SYSTEM 08/01/18 The crystal structure of bovine ultralong antibody BOV-7 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 2.295 X-RAY DIFFRACTION 0.257 0.214 False True IGHV1 IGLV1 Lambda None None None None None 7n0i L NA 0 G | H protein | protein NA | NA nucleoprotein | nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/25/21 Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Ye, Q., Corbett, K.D. 2.2 X-RAY DIFFRACTION 0.271 0.239 False True IGHV1 NA NA None None None None None 5o04 D NA 0 B protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 norovirus protruding domain in complex with Nanobody Nano-26 and Nano-85 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, A.D. 2.3 X-RAY DIFFRACTION 0.242 0.212 False True IGHV1 None None None None None 7cr5 H L 0 A protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/12/20 Complex structure of a human monoclonal antibody with SARS-CoV-2 nucleocapsid protein NTD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, S., Kang, S. 2.08 X-RAY DIFFRACTION 0.222 0.191 False True IGHV3 IGLV4 Lambda None None None None None 6p60 J K 0 L peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/03/20 Vaccine-elicited NHP FP-targeting neutralizing antibody A12V163-a.02 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.498 X-RAY DIFFRACTION 0.209 0.197 False True IGHV4 IGLV1 Lambda None None None None None 5gs1 P O 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 False True IGHV3 IGKV3 Kappa None None None None None 7m3n H L 0 A protein NA capsid protein 2 VIRUS/Immune System 03/18/21 Canine parvovirus and Fab14 asymmetric reconstruction MUS MUSCULUS; CANINE PARVOVIRUS TYPE 2 mus musculus mus musculus canine parvovirus type 2 Goteschius, D.J., Hartmann, S.R., Hafenstein, S.L. 2.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV6 Kappa None None None None None 6dc9 I M 0 Q peptide microtubule-associated protein tau IMMUNE SYSTEM 05/04/18 Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chukwu, J.E., Kong, X.-P. 2.999 X-RAY DIFFRACTION 0.260 0.202 False True IGHV14 IGKV15 Kappa None None None None None 7ew5 K L 0 G protein NA heavy chain of 13h5 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 7f6y H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Complex Structure of antibody BD-503 and RBD-E484K of COVID-19 Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xu, H., Wang, B., Zhao, T.N., Su, X.D. 3 X-RAY DIFFRACTION 0.253 0.198 False True IGHV3 IGKV1 Kappa None None None None None 7mgw B C 0 A protein NA sodium-dependent serotonin transporter MEMBRANE PROTEIN 04/13/21 5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Gouaux, E. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5tok D NA 0 B protein fusion glycoprotein f0, fibritin chimera VIRAL PROTEIN/IMMUNE SYSTEM 10/17/16 Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66 HUMAN RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama human respiratory syncytial virus Gilman, M.S.A., Kabeche, S.C., McLellan, J.S. 3.8 X-RAY DIFFRACTION 0.286 0.248 False True IGHV1 None None None None None 1kxt D NA 0 C protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 2.0 X-RAY DIFFRACTION 0.236 0.203 False True IGHV1 2.35e-07 -9.04 SPR 11960990 3eoa B A 0 J protein integrin alpha-l IMMUNE SYSTEM/CELL ADHESION 09/26/08 Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form I HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, S., Ding, J. 2.8 X-RAY DIFFRACTION 0.264 0.225 False True IGHV3 IGKV1 Kappa 2.20e-09 -11.8 SPR 25 19258452 6mwc G H 0 F protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.5 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 6ehw B b 0 IMMUNE SYSTEM 09/15/17 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery HOMO SAPIENS homo sapiens Hargreaves, D. 2.19 X-RAY DIFFRACTION 0.248 0.212 True True unknown unknown unknown None None None None None 5wtg D C 0 IMMUNE SYSTEM 12/11/16 Crystal structure of the Fab fragment of anti-HAV antibody R10 MUS MUSCULUS mus musculus mus musculus Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z. 2.907 X-RAY DIFFRACTION 0.266 0.201 False False IGHV5 IGKV4 Kappa None None None None None 1mfd H L 0 H carbohydrate GLA polysaccharide IMMUNOGLOBULIN 10/25/93 THE SOLUTION STRUCTURE OF A TRISACCHARIDE-ANTIBODY COMPLEX: COMPARISON OF NMR MEASUREMENTS WITH A CRYSTAL STRUCTURE MUS MUSCULUS mus musculus mus musculus mus musculus Zdanov, A., Cygler, M. 2.1 X-RAY DIFFRACTION unknown 0.183 False True IGHV1 IGLV1 Lambda 4.9000000000000005e-06 -7.243868613748499 Unknown TBD 6j6y B C 0 A protein fibroblast growth factor receptor 4 TRANSFERASE/IMMUNE SYSTEM 01/16/19 FGFR4 D2 - Fab complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Takahashi, M., Hanzawa, H. 2.15 X-RAY DIFFRACTION 0.258 0.193 False True IGHV3 IGLV1 Lambda None None None None None 7dv4 D NA 0 C protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 01/12/21 Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 HOMO SAPIENS homo sapiens homo sapiens Li, H., Gan, X., He, Y. 2.38 X-RAY DIFFRACTION 0.258 0.221 False True IGHV3 NA NA None None None None None 5cbe A B 0 E protein c-x-c motif chemokine 13 IMMUNE SYSTEM 06/30/15 E10 in complex with CXCL13 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tu, C., Bard, J., Mosyak, L. 2.4 X-RAY DIFFRACTION 0.275 0.248 True True IGHV1 IGLV2 Lambda None None None None None 4nm4 H L 0 immune system 11/14/13 Crystal structure of broadly neutralizing antibody CR8043 HOMO SAPIENS homo sapiens homo sapiens Lee, P.S., Wilson, I.A. 2.65 X-RAY DIFFRACTION 0.232 0.175 False False IGHV1 IGKV4 Kappa None None None None None 7lf1 K L 0 M protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3cm9 A L 3 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6vun A a 0 NA NA NA NA PROTEIN BINDING 02/16/20 Reverse Transcriptase Diabody with R83C Mutation HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 1.4 X-RAY DIFFRACTION 0.167 0.138 True True unknown unknown unknown None None None None None 6mpg q r 0 V protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False False unknown IGKV3 Kappa None None None None None 2gsg D C 0 IMMUNE SYSTEM 04/26/06 Crystal structure of the Fv fragment of a monoclonal antibody specific for poly-glutamine MUS MUSCULUS mus musculus mus musculus Li, P., Huey-Tubman, K.E., West Jr., A.P., Bennett, M.J., Bjorkman, P.J. 2.1 X-RAY DIFFRACTION 0.253 0.229 False True IGHV5 IGLV3 Lambda None None None None None 7kn7 B NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH W and antibody Fab CC12.3 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS; HOMO SAPIENS vicugna pacos severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.241 0.203 False True IGHV1 NA NA None None None None None 7ezv H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/02/21 local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-812 Fab and BD-836 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, P.L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7cwn H N 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 1yqv H L 0 Y protein hen egg white lysozyme IMMUNE SYSTEM 02/02/05 The crystal structure of the antibody Fab HyHEL5 complex with lysozyme at 1.7A resolution MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Cohen, G.H., Silverton, E.W., Padlan, E.A., Dyda, F., Wibbenmeyer, J.A., Wilson, R.C., Davies, D.R. 1.7 X-RAY DIFFRACTION 0.234 0.195 False False IGHV1 IGKV4 Kappa None None None None None 5csz A B 0 E peptide amyloid beta a4 protein IMMUNE SYSTEM 07/23/15 CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Benz, J., Burger, D., Loetscher, H.R., Bohrmann, B. 1.8 X-RAY DIFFRACTION 0.230 0.196 False True IGHV3 IGKV3 Kappa 1.7e-08 -10.599564136380756 Unknown TBD 3kym B A 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 1i9r X Y 0 C protein cd40 ligand CYTOKINE/IMMUNE SYSTEM 03/20/01 STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY HOMO SAPIENS homo sapiens homo sapiens homo sapiens Karpusas, M., Lucci, J., Ferrant, J., Benjamin, C., Hsu, Y.-M. 3.1 X-RAY DIFFRACTION 0.285 0.233 False False IGHV1 IGKV3D Kappa None None None None None 5tf1 H L 0 IMMUNE SYSTEM 09/23/16 Structure of chimeric 02-CC Fab, a VRC01-like germline antibody HOMO SAPIENS homo sapiens homo sapiens Pancera, M. 1.858 X-RAY DIFFRACTION 0.233 0.210 False True IGHV1 IGKV3 Kappa None None None None None 7kf1 A B 0 C protein NA isoform l-vegf206 of vascular endothelial growth factor a IMMUNE SYSTEM 10/13/20 Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M.S. 2.45 X-RAY DIFFRACTION 0.232 0.189 False True IGHV3 IGKV1 Kappa None None None None None 7nab A B 0 D peptide NA spike protein s2 VIRAL PROTEIN/IMMUNE SYSTEM 06/21/21 Crystal structure of human neutralizing mAb CV3-25 binding to SARS-CoV-2 S MPER peptide 1140-1165 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, Y., Tolbert, W.D., Pazgier, M. 2.15 X-RAY DIFFRACTION 0.239 0.185 False True IGHV5 IGKV1 Kappa None None None None None 7zxf D E 0 A protein NA gametocyte surface protein p45/48 CELL ADHESION 05/20/22 Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 Mus musculus; Plasmodium falciparum; Rattus norvegicus mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 3.72 X-RAY DIFFRACTION 0.298 0.281 False True IGHV5 IGKV8 Kappa None None None None None 7k66 B C 0 A protein NA coagulation factor viii,coagulation factor viii,coagulationfactor viii,coagulation factor viii BLOOD CLOTTING/Immune System 09/18/20 Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor SUS SCROFA; HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus sus scrofa, homo sapiens Childers, K.C., Gish, J., Jarvis, L., Peters, S., Garrels, C., Smith, I.W., Spencer, H.T., Spiegel, P.C. 3.92 X-RAY DIFFRACTION 0.322 0.226 False True IGHV9 IGKV4 Kappa None None None None None 6wbv H L 0 A protein NA solute carrier family 40 member 1 TRANSLOCASE/IMMUNE SYSTEM/HORMONE 03/27/20 Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Billesboelle, C.B., Azumaya, C.M., Gonen, S., Powers, A., Kretsch, R.C., Schneider, S., Arvedson, T., Dror, R.O., Cheng, Y., Manglik, A. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7ul7 H L 0 a protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 04/04/22 Lineage I (Pinneo) Lassa virus glycoprotein bound to 18.5C-M30 Fab LASSA MAMMARENAVIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa mammarenavirus Buck, T.K., Enriquez, A.S., Hastie, K.M. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 3ob0 M K 0 M Hapten 2M6 7-DEOXY-L-GLYCERO-ALPHA-D-MANNO-HEPTOPYRANOSYL-(1->2)-ALPHA-D-MANNOPYRANOSYL-(1->2)-ALPHA-D-MANNOPYRANOSYL-(1->3)-ALPHA-D-MANNOPYRANOSE IMMUNE SYSTEM 08/06/10 A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity HOMO SAPIENS homo sapiens homo sapiens homo sapiens Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G 2.85 X-RAY DIFFRACTION 0.280 0.232 False True IGHV3 IGKV1 Kappa None None None None None 6ppg H L 0 F protein interleukin-17f CYTOKINE 07/06/19 Crystal structure of IL17FF bound to Fab fragments of MCAF5352A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Huang, C.S., Yin, J.P., Hymowitz, S.G. 2.75 X-RAY DIFFRACTION 0.275 0.224 False True IGHV3 IGKV3 Kappa None None None None None 3j3p H L 0 1 protein protein vp1 VIRUS/IMMUNE SYSTEM 04/10/13 Conformational Shift of a Major Poliovirus Antigen Confirmed by Immuno-Cryogenic Electron Microscopy: 135S Poliovirus and C3-Fab Complex MUS MUSCULUS; HUMAN POLIOVIRUS 1 mus musculus mus musculus human poliovirus 1 Lin, J., Cheng, N., Hogle, J.M., Steven, A.C., Belnap, D.M. 9.1 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 1xf2 H L 0 T nucleic-acid 5'-d(*tp*tp*t)-3' IMMUNE SYSTEM/DNA 09/13/04 Structure of Fab DNA-1 complexed with dT3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J. 2.3 X-RAY DIFFRACTION 0.242 0.202 False True IGHV1 IGKV12 Kappa None None None None None 3j1s H L 0 A protein capsid protein vp1 VIRUS/IMMUNE SYSTEM 05/23/12 Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20 ADENO-ASSOCIATED VIRUS - 2; MUS MUSCULUS mus musculus mus musculus adeno-associated virus - 2 Chapman, M.S., McCraw, D.M. 8.5 ELECTRON MICROSCOPY / HOMOLOGY MODEL False False IGHV3 IGKV13 Kappa None None None None None 5vco B A 0 F protein peptidase 1 IMMUNE SYSTEM 03/31/17 THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 10B9 MUS MUSCULUS; DERMATOPHAGOIDES PTERONYSSINUS mus musculus mus musculus dermatophagoides pteronyssinus Osinski, T., Majorek, K.A., Pomes, A., Offermann, L.R., Osinski, S., Glesner, J., Vailes, L.D., Chapman, M.D., Minor, W., Chruszcz, M. 2.74 X-RAY DIFFRACTION 0.261 0.200 False True IGHV3 IGKV10 Kappa None None None None None 6phh C D 0 IMMUNE SYSTEM 06/25/19 Unliganded human transmission blocking antibody 2544 HOMO SAPIENS homo sapiens homo sapiens McLeod, B.R., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.249 0.218 False True IGHV3 IGKV2 Kappa None None None None None 6p79 H L 0 IMMUNE SYSTEM 06/05/19 Engineered single chain antibody C9+C14 ScFv MUS MUSCULUS mus musculus mus musculus Zhang, Y., Li, W., Marshall, N. 1.583 X-RAY DIFFRACTION 0.202 0.175 False True IGHV14 IGKV12 Kappa None None None None None 7k93 E e 0 A protein NA non-structural protein 1 VIRAL PROTEIN 09/28/20 DENV2 NS1 in complex with neutralizing 2B7 single chain Fab variable region (scFv) DENGUE VIRUS 2; MUS MUSCULUS mus musculus dengue virus 2 Akey, D.L., Smith, J.L. 2.89 X-RAY DIFFRACTION 0.269 0.223 True True unknown unknown unknown None None None None None 6vbp C D 0 E peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH815 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.298 X-RAY DIFFRACTION 0.229 0.180 False True IGHV5 IGKV4 Kappa None None None None None 7or9 A B 0 E protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and COVOX-278 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.34 X-RAY DIFFRACTION 0.230 0.194 False True IGHV3 IGKV3 Kappa None None None None None 3ubx H L 0 A protein antigen-presenting glycoprotein cd1d1 IMMUNE SYSTEM 10/25/11 Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex MUS MUSCULUS mus musculus mus musculus mus musculus Yu, E.D., Zajonc, D.M. 3.1 X-RAY DIFFRACTION 0.230 0.202 False False IGHV9 IGKV13 Kappa 2.52e-08 -10.366344400034732 Unknown TBD 7lf1 D E 0 B protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6fax H L 0 R protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 12/18/17 Complex of Human CD40 Ectodomain with Lob 7.4 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Orr, C.M., Tews, I., Pearson, A.R. 2.99 X-RAY DIFFRACTION 0.231 0.185 False True IGHV1 IGKV10 Kappa None None None None None 7b17 B NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/23/20 SARS-CoV-spike RBD bound to two neutralising nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS; LAMA GLAMA vicugna pacos, lama glama severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 4.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3sdy H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain Viral Protein/Immune System 06/09/11 Crystal Structure of Broadly Neutralizing Antibody CR8020 Bound to the Influenza A H3 Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Ekiert, D.C., Wilson, I.A. 2.85 X-RAY DIFFRACTION 0.235 0.202 False True IGHV1 IGKV3 Kappa 1.00E-09 -12.48 Other 30 21737702 1jgv H L 0 IMMUNE SYSTEM 06/26/01 STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4 MUS MUSCULUS mus musculus mus musculus Larsen, N.A., Heine, A., Crane, L., Cravatt, B.F., Lerner, R.A., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.247 0.206 False False IGHV5 IGKV1 Kappa None None None None None 7q6e H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/07/21 Beta049 fab in complex with SARS-CoV2 beta-Spike glycoprotein, The Beta mAb response underscores the antigenic distance to other SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1i8m B A 0 D nucleic-acid 5'-d(p*tp*t)-3' IMMUNE SYSTEM/DNA 03/14/01 CRYSTAL STRUCTURE OF A RECOMBINANT ANTI-SINGLE-STRANDED DNA ANTIBODY FRAGMENT COMPLEXED WITH DT5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Tanner, J.J., Komissarov, A.A., Deutscher, S.L. 2.1 X-RAY DIFFRACTION 0.258 0.220 False True IGHV1 IGKV12 Kappa 2.7e-06 -7.5969790708218685 Unknown TBD 3n9g H L 0 IMMUNE SYSTEM 05/29/10 Crystal structure of the Fab fragment of the human neutralizing anti-West Nile Virus MAb CR4354 HOMO SAPIENS homo sapiens homo sapiens Kaufmann, B., Rossmann, M.G. 1.434 X-RAY DIFFRACTION 0.186 0.167 False True IGHV1 IGLV1 Lambda None None None None None 6db5 I M 0 Q peptide hiv-1 gp120 v3 peptide from ny5 strain IMMUNE SYSTEM 05/02/18 Crystal structure of anti-HIV-1 V3 Fab TA6 in complex with a HIV-1 gp120 V3 peptide from NY5 strain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.-P. 2.599 X-RAY DIFFRACTION 0.283 0.227 False True IGHV1 IGLV3 Lambda None None None None None 1mh5 B A 0 B Hapten HAL N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE IMMUNE SYSTEM 08/19/02 The Structure Of The Complex Of The Fab Fragment Of The Esterolytic Antibody MS6-164 and A Transition-State Analog MUS MUSCULUS mus musculus mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 2.1 X-RAY DIFFRACTION 0.288 0.218 False True IGHV1 IGKV2 Kappa 6.100000000000001e-10 -12.571059308451574 Unknown TBD 6x97 J K 0 G protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11A fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6vyv I M 0 F protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/27/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain ROSS RIVER VIRUS (STRAIN T48); HOMO SAPIENS homo sapiens homo sapiens ross river virus (strain t48) Miller, A.S., Kuhn, R.J. 6.33 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 6swr D NA 0 TRANSPORT PROTEIN 09/23/19 Crystal structure of the lysosomal potassium channel MtTMEM175 T38A mutant soaked with zinc LAMA GLAMA; ESCHERICHIA COLI (STRAIN K12); MARIVIRGA TRACTUOSA (STRAIN ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) lama glama, escherichia coli (strain k12) Brunner, J.D., Jakob, R.P., Schulze, T., Neldner, Y., Moroni, A., Thiel, G., Maier, T., Schenck, S. 3.2 X-RAY DIFFRACTION 0.299 0.269 False True IGHV1 None None None None None 5kzp E I 0 B peptide c1 epitope VIRAL PROTEIN/IMMUNE SYSTEM 07/25/16 Structure of the HCV1-C1 Antibody-Antigen Complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Piepenbrink, K.H., Sundberg, E.J. 2.262 X-RAY DIFFRACTION 0.261 0.218 False True IGHV3 IGKV3 Kappa 7e-08 -9.761032709220395 Unknown TBD 2kh2 B b 27 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6dfh H L 0 A protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 05/14/18 BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Steichen, J.M., Schief, W.R., Ward, A.B. 3.85 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 1ztx H L 0 E protein envelope protein Viral protein/Immune system 05/27/05 West Nile Virus Envelope Protein DIII in complex with neutralizing E16 antibody Fab WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Nybakken, G.E., Oliphant, T., Diamond, M.S., Fremont, D.H. 2.5 X-RAY DIFFRACTION 0.282 0.208 False False IGHV1 IGKV6 Kappa None None None None None 6dcv B A 0 IMMUNE SYSTEM 05/08/18 Crystal structure of human anti-tau antibody CBTAU-27.1 HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Zhang, H., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.229 0.186 False True IGHV5 IGKV4 Kappa None None None None None 7v0v A NA 4 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6azz F E 0 D protein pfs25 IMMUNE SYSTEM 09/13/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1190 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum Scally, S.W., McLeod, B., Bosch, A., King, C.R., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.217 0.191 False True IGHV1 IGLV3 Lambda 6.7000000000000004e-09 -11.151229137696946 BLI TBD 7na7 N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/20/21 Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Liu, H., Sun, D., Sun, J., Zhang, C. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6ikm B b 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 5ken G H 0 F protein ebola surface glycoprotein, gp2 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76); ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV1 IGKV12 Kappa None None None None None 2fjg B A 0 V protein vascular endothelial growth factor a HORMONE/GROWTH FACTOR/IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 2.8 X-RAY DIFFRACTION 0.239 0.199 False True IGHV3 IGKV1 Kappa 2.00e-08 -10.92 SPR 37 16373345 6wt3 H L 0 NA NA NA NA IMMUNE SYSTEM 05/01/20 Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase MUS MUSCULUS mus musculus mus musculus Luz, J.G., Birrane, G., Young, S.G., Meiyappan, M., Ploug, M. 2.85 X-RAY DIFFRACTION 0.308 0.253 False False IGHV1 IGKV4 Kappa None None None None None 5u68 E e 0 A protein chimera protein of fusion glycoprotein f0 and envelopeglycoprotein VIRAL PROTEIN/Immune System 12/07/16 Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); MYZUS PERSICAE myzus persicae human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Wen, X., Jardetzky, T.S. 3.083 X-RAY DIFFRACTION 0.239 0.184 True True unknown unknown unknown None None None None None 7fg2 D NA 0 A protein NA spike glycoprotein PROTEIN BINDING 07/25/21 Minor cryo-EM structure of S protein trimer of SARS-CoV2 with K-874A VHH, composite map SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Song, C., Murata, K., Katayama, K. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7lxy N O 0 J protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2X333 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 3qhz I M 0 IMMUNE SYSTEM 01/26/11 Crystal Structure of human anti-influenza Fab 2D1 HOMO SAPIENS homo sapiens homo sapiens Ekiert, D.C., Wilson, I.A. 1.55 X-RAY DIFFRACTION 0.206 0.180 False True IGHV2 IGLV1 Lambda None None None None None 5f7m D NA 0 B protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.72 X-RAY DIFFRACTION 0.218 0.179 False True IGHV1 None None None None None 5ghw H L 0 P peptide endogenous retrovirus group k member 8 env polyprotein IMMUNE SYSTEM 06/21/16 Crystal structure of broad neutralizing antibody 10E8 with long epitope bound HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caaveiro, J.M.M., Rujas, E., Morante, K., Nieva, J.L., Tsumoto, K. 2.4 X-RAY DIFFRACTION 0.230 0.192 False True IGHV3 IGLV3 Lambda 9.6e-09 -10.938139080820335 Unknown TBD 5m6a NA D 0 IMMUNE SYSTEM 10/24/16 Crystal structure of cardiotoxic Bence-Jones light chain dimer H9 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 1.64 X-RAY DIFFRACTION 0.203 0.183 False False IGLV2 Lambda None None None None None 6azk B A 0 IMMUNE SYSTEM 09/11/17 Structure of cetuximab with aminoheptanoic acid-linked N-(3-hydroxypropyl)-L-arginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.477 X-RAY DIFFRACTION 0.213 0.170 False True IGHV2 IGKV5 Kappa 2.2999999999999996e-06 -7.691979474199363 Unknown TBD 4k3g NA B 0 B carbohydrate MAN ALPHA-D-MANNOSE IMMUNE SYSTEM 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activating protein HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 1.93 X-RAY DIFFRACTION 0.231 0.193 False True IGLV7 Lambda None None None None None 7qnc G NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6jsz D NA 0 A protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 04/08/19 BACE2 xaperone complex with N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9lambda6-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Fujimoto, K., Matsuoka, E., Asada, N., Tadano, G., Yamamoto, T., Nakahara, K., Fuchino, K., Ito, H., Kanegawa, N., Moechars, D., Gijsen, H.J.M., Kusakabe, K.I. 1.53 X-RAY DIFFRACTION 0.237 0.225 False True IGHV3 None None None None None 7z1b D NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-A10 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.3 X-RAY DIFFRACTION 0.243 0.198 False True IGHV1 NA NA None None None None None 7s0d H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-014 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7niw C B 0 A protein NA phosphatidylcholine translocator abcb4 PROTEIN TRANSPORT 02/14/21 Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nosol, K., Locher, K.P. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5vm4 A NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 6dzl I L 0 D | C protein | protein NA | NA ebola virus makona gp2 | ebola virus makona gp1 VIRAL PROTEIN 07/05/18 Ebola virus Makona variant GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus | zaire ebolavirus Murin, C.D., Ward, A.B. 4.14 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 4xbg G I 0 IMMUNE SYSTEM 12/16/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA): 2.73 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGKV3 Kappa None None None None None 7n9v H NA 0 K protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/21 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Tripler, T.N. 3.45 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 NA NA None None None None None 3hae I G 0 D | F protein | peptide NA | NA hla class i histocompatibility antigen, a-2 alpha chain | nyeso-1 peptide IMMUNE SYSTEM 05/01/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E. 2.9 X-RAY DIFFRACTION 0.283 0.201 False True IGHV3 IGLV2 Lambda 4.60e-08 -10 SPR 19307587 6cvk B b 0 D protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/28/18 Hepatitis B e-antigen in complex with scFv e13 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS oryctolagus cuniculus hepatitis b virus Eren, E., Steven, A.C., Wingfield, P.T. 2.38 X-RAY DIFFRACTION 0.221 0.175 True True unknown unknown unknown None None None None None 7t0h H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-39 Fab Unliganded 2 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 1.3 X-RAY DIFFRACTION 0.200 0.148 False True IGHV7 IGKV8 Kappa None None None None None 1mcn NA A 0 P peptide peptide n-acetyl-d-his-l-pro-nh2 IMMUNE SYSTEM 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown 0.183 False True IGLV2 Lambda None None None None None 7czs H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B8_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5bo1 H L 0 B protein protein jagged-1 Signaling protein/Immune system 05/26/15 Crystal structure of a human Jag1 fragment in complex with an anti-Jag1 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Payandeh, J., de Leon-Boenig, G. 2.56 X-RAY DIFFRACTION 0.259 0.220 False True IGHV3 IGKV1 Kappa 7.900000000000001e-10 -12.41785844031504 SPR TBD 5u68 G g 0 C protein chimera protein of fusion glycoprotein f0 and envelopeglycoprotein VIRAL PROTEIN/Immune System 12/07/16 Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); MYZUS PERSICAE myzus persicae human respiratory syncytial virus a (straina2), human immunodeficiency virus 1 Wen, X., Jardetzky, T.S. 3.083 X-RAY DIFFRACTION 0.239 0.184 True True unknown unknown unknown None None None None None 5gks A B 0 IMMUNE SYSTEM 07/05/16 Crystal structure of SLE patient-derived anti-DNA antibody HOMO SAPIENS homo sapiens homo sapiens Arimori, T., Sakakibara, S., Kikutani, H., Takagi, J. 2.05 X-RAY DIFFRACTION 0.255 0.217 False True IGHV4 IGLV2 Lambda None None None None None 7zmt C NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.5 X-RAY DIFFRACTION 0.288 0.254 False True IGHV1 NA NA None None None None None 6orn O P 0 R protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.05 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 5kel P T 0 G protein ebola surface glycoprotein, gp2 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 ZAIRE EBOLAVIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV6 IGKV12 Kappa None None None None None 7nk2 F NA 0 NA NA NA NA VIRAL PROTEIN 02/17/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.84 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ndd F G 0 A protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-159 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6b73 D NA 0 A protein soluble cytochrome b562, kappa-type opioid receptor MEMBRANE PROTEIN/AGONIST 10/03/17 Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor ESCHERICHIA COLI; HOMO SAPIENS; LAMA GLAMA lama glama escherichia coli, homo sapiens Che, T., Majumdar, S., Zaidi, S.A., Kormos, C., McCorvy, J.D., Wang, S., Mosier, P.D., Uprety, R., Vardy, E., Krumm, B.E., Han, G.W., Lee, M.Y., Pardon, E., Steyaert, J., Huang, X.P., Strachan, R.T., Tribo, A.R., Pasternak, G.W., Carroll, I.F., Stevens, R.C., Cherezov, V., Katritch, V., Wacker, D., Roth, B.L. 3.1 X-RAY DIFFRACTION 0.275 0.254 False True IGHV1 None None None None None 2omb NA A 0 Immune system 01/21/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(1)21 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.9 X-RAY DIFFRACTION 0.284 0.235 False False IGLV2 Lambda None None None None None 3auv D d 0 IMMUNE SYSTEM 02/16/11 Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface HOMO SAPIENS homo sapiens Yu, C.M., Peng, H.P., Chen, I.C., Lee, Y.C., Chen, J.B., Tsai, K.C., Chen, C.T., Chang, J.Y., Yang, E.W., Hsu, P.C., Jian, J.W., Hsu, H.J., Chang, H.J., Hsu, W.L., Huang, K.F., Ma, A.C., Yang, A.S. 2.4 X-RAY DIFFRACTION 0.251 0.216 True True unknown unknown unknown None None None None None 7a25 E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/16/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5u15 H L 0 IMMUNE SYSTEM 11/27/16 Crystal Structure of DH270.UCA3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.26 X-RAY DIFFRACTION 0.255 0.216 False True IGHV1 IGLV2 Lambda None None None None None 1i3v B NA 0 NA NA NA NA IMMUNE SYSTEM 02/16/01 THREE-DIMENSIONAL STRUCTURE OF A LAMA VHH DOMAIN UNLIGANDED LAMA GLAMA lama glama Spinelli, S., Tegoni, M., Frenken, L., van Vliet, C., Cambillau, C. 2.03 X-RAY DIFFRACTION 0.250 0.212 False True IGHV1 NA NA None None None None None 2w0k NA A 0 IMMUNE SYSTEM 08/19/08 Crystal structure of the recombinant variable domain 6JAL2 HOMO SAPIENS homo sapiens Rudino-Pinera, E., Gonzalezrubio-Garrido, P., Horjales, E. 2.35 X-RAY DIFFRACTION 0.242 0.209 False False IGLV6 Lambda None None None None None 7qbg G NA 0 A | D protein | protein NA | NA transcobalamin-2 | cd320 antigen TRANSPORT PROTEIN 11/19/21 TC:CD320 in complex with nanobody TC-Nb4 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens | homo sapiens Bloch, J.S., Locher, K.P. 2.69 X-RAY DIFFRACTION 0.285 0.227 False True IGHV1 NA NA None None None None None 1t04 D C 0 IMMUNE SYSTEM 04/07/04 Three dimensional structure of a humanized anti-IFN-Gamma Fab in C2 space group HOMO SAPIENS homo sapiens homo sapiens Bourne, P.C., Terzyan, S.S., Cloud, G., Landolfi, N.F., Vasquez, M., Edmundson, A.B. 3.0 X-RAY DIFFRACTION 0.293 0.217 False True IGHV1 IGKV1 Kappa None None None None None 1lo4 H L 0 IMMUNE SYSTEM 07/03/02 Retro-Diels-Alderase Catalytic antibody 9D9 MUS MUSCULUS mus musculus mus musculus Hugot, M., Reymond, J.L., Baumann, U. 2.4 X-RAY DIFFRACTION 0.308 0.235 False False IGHV5 IGKV1 Kappa None None None None None 5waw H L 0 IMMUNE SYSTEM 06/27/17 FcAbVance: Increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Williams, S.P., Reid, R.A., Convery, M. 2.25 X-RAY DIFFRACTION 0.280 0.231 False True IGHV3 IGKV2 Kappa None None None None None 4m5y I M 0 IMMUNE SYSTEM 08/08/13 Crystal structure of broadly neutralizing Fab 5J8 HOMO SAPIENS homo sapiens homo sapiens Lee, P.S., Wilson, I.A. 1.55 X-RAY DIFFRACTION 0.186 0.172 False True IGHV4 IGLV3 Lambda None None None None None 7p5w G NA 0 A protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb2 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3chn A L 0 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 6a9k B A 0 B Hapten 9T0 5-[(2R,3R)-2-[2,2-bis(chloranyl)ethanoylamino]-3-(4-nitrophenyl)-3-[oxidanyl-[[4-[2,2,2-tris(fluoranyl)ethanoylamino]phenyl]methyl]phosphoryl]oxy-propoxy]-5-oxidanylidene-pentanoic acid IMMUNE SYSTEM 07/13/18 Crystal structure of the complex of the hydrolytic antibody Fab 9C10 with a transition-state analog MUS MUSCULUS mus musculus mus musculus mus musculus Tsuchiya, Y., Fujii, I., Tada, T., Yamaguchi, A., Tsumuraya, T., Kumon, A. 1.9 X-RAY DIFFRACTION 0.249 0.194 False False IGHV5 IGKV1 Kappa None None None None None 5jw4 Q R 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment in Complex with H5 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 3.7 X-RAY DIFFRACTION 0.285 0.274 False True IGHV6 IGKV1 Kappa None None None None None 7kdu C NA 0 B | A protein | protein NA | NA ricin chain b | ricin chain a TOXIN 10/09/20 Ricin bound to VHH antibody V5E4 VICUGNA PACOS; RICINUS COMMUNIS vicugna pacos ricinus communis | ricinus communis Rudolph, M.J. 2.809 X-RAY DIFFRACTION 0.294 0.237 False True IGHV1 NA NA None None None None None 2omb NA B 0 Immune system 01/21/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(1)21 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.9 X-RAY DIFFRACTION 0.284 0.235 False False IGLV2 Lambda None None None None None 6xey H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/Immune System 06/14/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L., Ho, D.D. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6mtp H L 0 P peptide rv217 founder virus gp41 peptide IMMUNE SYSTEM 10/21/18 Crystal structure of VRC42.04 Fab in complex with gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Druz, A., Law, W.H., Peng, D., Zhang, B., Doria-Rose, N.A., Kwong, P.D. 2.036 X-RAY DIFFRACTION 0.223 0.199 False True IGHV1 IGKV3 Kappa None None None None None 3nh7 I M 0 B protein bone morphogenetic protein receptor type-1a IMMUNE SYSTEM 06/14/10 Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mueller, T.D., Harth, S., Sebald, W. 2.7 X-RAY DIFFRACTION 0.280 0.234 False True IGHV3 IGLV3 Lambda 2.00e-08 -10.5 SPR 25 20927405 4hcr H L 0 A protein mucosal addressin cell adhesion molecule 1 IMMUNE SYSTEM 10/01/12 Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Springer, T., Yu, Y., Zhu, J. 2.3 X-RAY DIFFRACTION 0.208 0.153 False True IGHV1 IGKV2D Kappa None None None None None 6ejg D d 0 B protein cd81 antigen CELL ADHESION 09/21/17 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 4 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Harris, S.F., Wong, A., Kuglstatter, A. 2.82 X-RAY DIFFRACTION 0.263 0.227 True True unknown unknown unknown 8.100000000000001e-10 -12.403045576779583 SPR TBD 7t4s J K 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11 HUMAN BETAHERPESVIRUS 5; HOMO SAPIENS homo sapiens homo sapiens human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 2a0l D C 0 A protein voltage-gated potassium channel Membrane Protein 06/16/05 Crystal structure of KvAP-33H1 Fv complex AEROPYRUM PERNIX; MUS MUSCULUS mus musculus mus musculus aeropyrum pernix Lee, S.Y., Lee, A., Chen, J., Mackinnon, R. 3.9 X-RAY DIFFRACTION 0.392 0.358 False False IGHV3 IGKV4 Kappa None None None None None 1yym H L 0 G protein exterior membrane glycoprotein(gp120) Viral protein/Immune system 02/25/05 crystal structure of F23, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.C., Stricher, F., Martin, L., Decker, J.M., Majeed, S., Barthe, P., Hendrickson, W.A., Robinson, J., Roumestand, C., Sodroski, J., Wyatt, R., Shaw, G.M., Vita, C., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.268 0.209 False True IGHV1 IGKV3 Kappa 9.48e-06 -6.852859535761411 SPR TBD 7aue S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/02/20 Melanocortin receptor 4 (MC4R) Gs protein complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Degtjarik, O., Israeli, H., Prabahar, V., Shalev-Benami, M. 2.97 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6hhc H L 0 A protein coagulation factor xi BLOOD CLOTTING 08/27/18 Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schaefer, M., Buchmueller, A., Dittmer, F., Strassburger, J., Wilmen, A. 2.7 X-RAY DIFFRACTION 0.314 0.227 False True IGHV3 IGKV1 Kappa None None None None None 4xcn C D 0 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA); 2.9 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.246 0.193 False True IGHV1 IGKV3 Kappa None None None None None 5udc H L 0 F protein fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F A2 Bound to MEDI8897 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2) homo sapiens homo sapiens human respiratory syncytial virus a (straina2) McLellan, J.S. 3.45 X-RAY DIFFRACTION 0.232 0.175 False True IGHV1 IGKV1 Kappa None None None None None 7mxp I K 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/19/21 Cryo-EM structure of NTD-directed neutralizing antibody LP5 Fab in complex with SARS-CoV-2 S2P spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Casner, R.G., Shapiro, L. 4.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6q20 H L 0 A protein neuraminidase VIRAL PROTEIN,HYDROLASE/IMMUNE SYSTEM 08/06/19 Crystal structure of human 1E01 Fab in complex with influenza virus neuraminidase from A/Japan/305/1957 (H2N2) INFLUENZA A VIRUS (STRAIN A/JAPAN/305/1957 H2N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/japan/305/1957h2n2) Zhu, X., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.272 0.217 False True IGHV3 IGKV1 Kappa None None None None None 2kqn NA A 18 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1vge H L 0 IMMUNOGLOBULIN 01/04/96 TR1.9 FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY HOMO SAPIENS homo sapiens homo sapiens Chacko, S., Padlan, E.A. 2.0 X-RAY DIFFRACTION unknown 0.180 False True IGHV1 IGKV1 Kappa None None None None None 7whz H L 0 A protein NA spike protein s1 VIRAL PROTEIN 01/01/22 SARS-CoV-2 spike protein in complex with three human neutralizing antibodies Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, Q., Li, S., Sun, H., Zheng, Z., Wang, S. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5uhy J I 0 C | E protein | protein NA | NA envelope protein | envelope protein VIRUS/IMMUNE SYSTEM 01/12/17 A Human Antibody Against Zika Virus Crosslinks the E Protein to Prevent Infection HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus | zika virus Hasan, S.S., Miller, A., Sapparapu, G., Fernandez, E., Klose, T., Long, F., Fokine, A., Porta, J.C., Jiang, W., Diamond, M.S., Crowe Jr., J.E., Kuhn, R.J., Rossmann, M.G. 6.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7mfg J K 0 I | G protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 04/09/21 Cryo-EM structure of the VRC310 clinical trial, vaccine-elicited, human antibody 310-030-1D06 Fab in complex with an H1 NC99 HA trimer INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7whj D NA 0 C | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 12/30/21 The state 1 complex structure of Omicron spike with Bn03 (1-up RBD, 3 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6oy4 D C 0 A protein der p 2 variant 3 allergen/immune system 05/14/19 Crystal structure of complex between recombinant Der p 2.0103 and Fab fragment of 7A1 DERMATOPHAGOIDES PTERONYSSINUS; MUS MUSCULUS mus musculus mus musculus dermatophagoides pteronyssinus Kapingidza, A.B., Offermann, L.R., Glesner, J., Wunschmann, S., Vailes, L.D., Chapman, M.D.C., Pomes, A., Chruszcz, M. 2.45 X-RAY DIFFRACTION 0.260 0.203 False True IGHV9 IGKV3 Kappa None None None None None 5a16 C D 0 04/28/15 Crystal structure of Fab4201 raised against Human Erythrocyte Anion Exchanger 1 MUS MUSCULUS mus musculus mus musculus Arakawa, T., Kobayashi-Yugiri, T., Alguel, Y., Weyand, S., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Ikeda-Suno, C., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A., Kobayashi, T., Hamasaki, N., Iwata, S. 2.5 X-RAY DIFFRACTION 0.2552 0.2128 False False IGHV8 IGKV3 Kappa None None None None None 7e7y A B 0 R protein NA spike protein s1 VIRAL PROTEIN 02/28/21 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-623 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wei, Y., Xiao, J. 2.41 X-RAY DIFFRACTION 0.241 0.197 False True IGHV3 IGLV2 Lambda None None None None None 7e3k H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/09/21 Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Li, T., Liu, F., Gao, Y., Ji, X., Yang, H. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7raj H L 0 A peptide NA asn-pro-asp-pro-asn-ala-asn-pro-asn-val-asp-pro-asn-ala-asn IMMUNE SYSTEM 07/01/21 Structure of PfCSP peptide 21 with antibody iGL-CIS43.D3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Tripathi, P., Kwong, P.D. 3.0 X-RAY DIFFRACTION 0.317 0.253 False True IGHV1 IGKV4 Kappa None None None None None 7lss H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/18/21 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 5wnb I M 0 A peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 07/31/17 Structure of antibody 3D3 bound to the linear epitope of RSV G HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human respiratory syncytial virus a Fedechkin, S.O., George, N.L., Wolff, J.T., Kauvar, L.M., DuBois, R.M. 2.4 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV3 Kappa None None None None None 2d03 H L 0 IMMUNE SYSTEM 07/23/05 Crystal structure of the G91S mutant of the NNA7 Fab MUS MUSCULUS mus musculus mus musculus Xie, K., Song, S.C., Spitalnik, S.L., Wedekind, J.E. 1.97 X-RAY DIFFRACTION 0.262 0.218 False True IGHV2 IGKV1 Kappa None None None None None 4ut9 K O 0 C protein envelope glycoprotein e VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein dimer in complex with the ScFv fragment of the broadly neutralizing human antibody EDE1 C10 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 3.2 X-RAY DIFFRACTION 0.2487 0.1975 False True IGHV1 IGLV2 Lambda None None None None None 5kov Q q 0 N protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 7fae e d 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 S protein of SARS-CoV-2 in complex bound with P36-5D2(state2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, L., Wang, X., Shan, S., Zhang, S. 3.65 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 7wkx B D 0 E protein NA interleukin-17a CYTOKINE 01/12/22 IL-17A in complex with the humanized antibody HB0017 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xu, J., Zhu, X., He, Y. 2.81 X-RAY DIFFRACTION 0.254 0.206 False True IGHV7 IGKV2 Kappa None None None None None 7ll2 H L 0 A protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/03/21 Cryo-EM structure of BG505 DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody VRC33.01 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 4kk5 C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the CLC-ec1 deltaNC construct in 20mM fluoride and 20mM bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.171 X-RAY DIFFRACTION 0.271 0.232 False True IGHV4 IGKV4 Kappa None None None None None 7myz H L 0 C protein NA fusion protein of leukocyte surface antigen cd47 an solublecytochrome b562 MEMBRANE PROTEIN 05/22/21 Structure of the full length 5-TM receptor CD47 bound to Fab B6H12 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens homo sapiens homo sapiens, escherichia coli Fenalti, G., Villanueva, N. 3.4 X-RAY DIFFRACTION 0.277 0.253 False True IGHV5 IGKV5 Kappa None None None None None 3ri5 J M 0 E protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.4 X-RAY DIFFRACTION 0.248 0.232 False True IGHV1 IGLV1 Lambda None None None None None 7a0x E F 0 B protein NA na(+)/h(+) antiporter nhaa MEMBRANE PROTEIN 08/11/20 Structure of dimeric sodium proton antiporter NhaA, at pH 6.0, crystallized with chimeric Fab antibodies SALMONELLA TYPHIMURIUM (STRAIN LT2 / SGSC1412 / ATCC 700720); GALLUS GALLUS; HOMO SAPIENS gallus gallus, homo sapiens gallus gallus, homo sapiens salmonella typhimurium (strain lt2 / sgsc1412 /atcc 700720) Fippel, A., Lentes, C.J., Mir, S.H., Wirth, C., Hunte, C. 2.37 X-RAY DIFFRACTION 0.241 0.205 False True unknown unknown unknown None None None None None 4xml H L 0 IMMUNE SYSTEM 01/14/15 Crystal structure of Fab of HIV-1 gp120 V3-specific human monoclonal antibody 2424 HOMO SAPIENS homo sapiens homo sapiens Pan, R., Kong, X.-P. 2.68 X-RAY DIFFRACTION 0.285 0.200 False True IGHV3 IGKV2 Kappa None None None None None 6qna C D 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV hybrid Fab B13HC-B4LC BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.62 X-RAY DIFFRACTION 0.250 0.220 False True IGHV1 IGLV1 Lambda None None None None None 6um7 B C 0 I protein envelope glycoprotein gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of vaccine-elicited HIV-1 neutralizing antibody DH270.mu1 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunders, K., Haynes, B.F. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7bua G I 0 B protein genome polyprotein VIRUS 05/13/20 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5w1g H L 0 IMMUNE SYSTEM 06/03/17 CR1-07 unliganded Fab HOMO SAPIENS homo sapiens homo sapiens Raymond, D.D., Clark, L.E., Abraham, J. 2.0 X-RAY DIFFRACTION 0.282 0.231 False True IGHV3 IGKV4 Kappa None None None None None 6k64 NA B 0 H protein protein a STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (8188-3LRH) HOMO SAPIENS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS homo sapiens staphylococcus aureus subsp. aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.933 X-RAY DIFFRACTION 0.207 0.171 False True IGLV1 Lambda None None None None None 6was A B 0 G protein NA 1fd6 16055 v1v2 scaffold IMMUNE SYSTEM 03/26/20 Structure of D19.PA8 Fab in complex with 1FD6 16055 V1V2 scaffold HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Singh, S., Liban, T.J., Pancera, M. 1.904 X-RAY DIFFRACTION 0.228 0.194 False True IGHV3 IGLV6 Lambda None None None None None 7ljc N NA 0 A | B | G protein | protein | protein NA | NA | NA engineered human gs alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 01/28/21 Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; LAMA GLAMA lama glama homo sapiens | rattus norvegicus | bos taurus Zhuang, Y., Krumm, B., Zhang, H., Zhou, X.E., Wang, Y., Guo, J., Huang, X.-P., Liu, Y., Wang, L., Cheng, X., Jiang, Y., Jiang, H., Melcher, K., Zhang, C., Yi, W., Roth, B.L., Zhang, Y., Xu, H.E. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6n1w q r 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 2bmk H L 0 IMMUNE SYSTEM 03/14/05 Fab fragment of PLP-dependent catalytic antibody 15A9 in complex with phosphopyridoxyl-D-alanine MUS MUSCULUS mus musculus mus musculus Pimpaneau, B.Golinelli-, Christen, P. 2.3 X-RAY DIFFRACTION 0.2725 0.2097 False True IGHV7 IGKV4 Kappa 2.4e-06 -7.666763597229133 Unknown TBD 2kqn NA A 15 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 4ffv D C 0 B protein dipeptidyl peptidase 4 HYDROLASE/Immune System, INHIBITOR 06/01/12 Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Sudom, A., Walker, N.P., Min, X. 2.4 X-RAY DIFFRACTION 0.301 0.271 False False IGHV1 IGKV4 Kappa None None None None None 6x3w J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.3 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 7klw C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 11/01/20 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 2.6 X-RAY DIFFRACTION 0.255 0.206 False True IGHV1 NA NA None None None None None 6nb6 H L 0 C | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRUS 12/06/18 SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 1) SARS CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus | sars coronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 4.2 ELECTRON MICROSCOPY False True IGHV3 IGKV2 Kappa None None None None None 7s0e H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 S1 subunit in complex with antibody N-612-004 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 4.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6id4 C D 0 E | F protein | protein NA | NA mhc class i antigen | beta-2-microglobulin IMMUNE SYSTEM 09/08/18 Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Lescar, J., Wong, Y.H., Liew, C.W., Gu, Y., MacAry, P.A. 2.4 X-RAY DIFFRACTION 0.246 0.197 False True IGHV1 IGLV5 Lambda None None None None None 6oca C NA 0 A protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V2G10 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 2.113 X-RAY DIFFRACTION 0.247 0.213 False True IGHV1 None None None None None 2a1w H L 0 IMMUNE SYSTEM 06/21/05 Anti-cocaine antibody 7.5.21, crystal form I MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Ringe, D., Petsko, G.A. 2.7 X-RAY DIFFRACTION 0.247 0.185 False False IGHV5 IGKV1 Kappa None None None None None 2a6d H L 0 IMMUNE SYSTEM 07/02/05 Crystal structure analysis of the anti-arsonate germline antibody 36-65 in complex with a phage display derived dodecapeptide RLLIADPPSPRE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M. 2.9 X-RAY DIFFRACTION 0.264 0.230 False False IGHV1 IGKV10 Kappa 1.5e-07 -9.309477166508257 Unknown TBD 7cho B C 0 A protein NA spike protein s1 VIRAL PROTEIN 07/06/20 Crystal structure of SARS-CoV-2 antibody P5A-1D2 with RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J., Wang, R., Zhang, Q. 2.561 X-RAY DIFFRACTION 0.247 0.202 False True IGHV3 IGLV1 Lambda None None None None None 7q0g H L 0 E protein NA spike protein s1 VIRAL PROTEIN 10/14/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-49 and FI-3A Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 1.82 X-RAY DIFFRACTION 0.224 0.192 False True IGHV3 IGKV1 Kappa None None None None None 5chn H L 0 IMMUNE SYSTEM 07/10/15 Fab fragments of chikungunya virus neutralizing human monoclonal antibody 5M16 HOMO SAPIENS homo sapiens homo sapiens Long, F., Crowe, J.E., Rossmann, M.G. 2.047 X-RAY DIFFRACTION 0.218 0.172 False False IGHV1 IGKV2 Kappa None None None None None 7jwp A B 0 Q peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 6lz4 A B 0 C peptide map peptide IMMUNE SYSTEM 05/20/20 Crystal structure of PMab-1 Fv-clasp fragment with its antigen peptide RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus mus musculus Arimori, T., Takagi, J. 2.49 X-RAY DIFFRACTION 0.269 0.245 False True IGHV1 IGKV3 Kappa None None None None None 7dcc A F 0 K protein NA spike glycoprotein VIRAL PROTEIN 10/24/20 S-3C1-F3b structure, all the three RBDs are in the up conformation and each of them associates with a 3C1 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 4.3 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 3rhw J M 0 E protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.26 X-RAY DIFFRACTION 0.270 0.239 False True IGHV1 IGLV1 Lambda None None None None None 6umh h l 0 IMMUNE SYSTEM 10/09/19 Crystal structure of erenumab Fab-a HOMO SAPIENS homo sapiens homo sapiens Mohr, C. 2.15 X-RAY DIFFRACTION 0.224 0.185 False False IGHV3 IGLV1 Lambda None None None None None 6uj9 H L 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen, b-7 alpha chain | isocitrate dehydrogenase [nadp], mitochondrial IMMUNE SYSTEM 10/02/19 Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide in complex with Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Miller, M.S., Thirawatananond, P., Aytenfisu, T.Y., Wright, K., Gabelli, S.B. 2.9 X-RAY DIFFRACTION 0.287 0.214 False True IGHV3 IGKV1 Kappa None None None None None 4m1c C D 0 A protein insulin-degrading enzyme HYDROLASE 08/02/13 Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens McCord, L.M., Liang, W., Farcasanu, M., Scherpelz, K., Meredith, S.C., Koide, S., Tang, W.J. 3.5007 X-RAY DIFFRACTION 0.270 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7tcc H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 2w0l NA A 0 IMMUNE SYSTEM 08/19/08 CRYSTAL STRUCTURE OF THE MUTANT H8P FROM THE RECOMBINANT VARIABLE DOMAIN 6JAL2 HOMO SAPIENS homo sapiens RUDINO-PINERA, E., GONZALEZRUBIO-GARRIDO, P., HORJALES, E. 2.2 X-RAY DIFFRACTION 0.245 0.206 False False IGLV6 Lambda None None None None None 5cd3 A B 0 IMMUNE SYSTEM 07/02/15 Structure of immature VRC01-class antibody DRVIA7 HOMO SAPIENS homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.234 False True unknown IGKV1 Kappa None None None None None 5myx B A 0 E peptide pyroglutamate-abeta pe3-18 IMMUNE SYSTEM 01/30/17 Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Parthier, C., Piechotta, A., Stubbs, M.T. 1.492 X-RAY DIFFRACTION 0.213 0.181 False True IGHV1 IGKV1 Kappa 6.85e-09 -11.13811088195787 Unknown TBD 4ogy H L 0 A protein plasma kallikrein HYDROLASE/ANTIBODY 01/16/14 Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Edwards, T.E., Clifton, M.C., Abendroth, J., Nixon, A., Ladner, R. 2.1 X-RAY DIFFRACTION 0.221 0.183 False True IGHV3 IGKV1 Kappa None None None None None 7ew3 S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein HOMO SAPIENS homo sapiens homo sapiens | homo sapiens | homo sapiens Zhao, C., Wang, W., Wang, H.L., Shao, Z.H. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7p79 D NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybodyb#15 in a 1up/1up-out/1down conformation. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6m47 H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 03/05/20 X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in tramadol bound form DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Shabareesh, P., Mallela, A.K., Joseph, D., Penmatsa, A. 3.252 X-RAY DIFFRACTION 0.275 0.241 False True IGHV5 IGKV4 Kappa None None None None None 3cfk D C 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 3mug L K 0 I carbohydrate NAG polysaccharide IMMUNE SYSTEM 05/03/10 Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pejchal, R., Walker, L.M., Burton, D.R., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGLV2 Lambda None None None None None 7rlz D C 0 R peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRAAGQPAGNGAGGQAA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.27 X-RAY DIFFRACTION 0.239 0.191 False True IGHV1 IGKV1 Kappa None None None None None 7n5h J K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/21 Cryo-EM structure of broadly neutralizing antibody 2-36 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Cerutti, G., Shapiro, L. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 2ipu H L 0 Q peptide abeta 1-8 peptide IMMUNE SYSTEM 10/12/06 PFA1 Fab fragment complexed with Abeta 1-8 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Gardberg, A.S., Dealwis, C. 1.65 X-RAY DIFFRACTION 0.225 0.182 False False IGHV8 IGKV1 Kappa None None None None None 5d1x C D 0 E protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT2 bound by D4-30 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN USA300) homo sapiens homo sapiens staphylococcus aureus (strain usa300) Deng, X. 3.21 X-RAY DIFFRACTION 0.310 0.269 False True IGHV3 IGKV3 Kappa 2.1e-11 -14.567099215178107 SPR TBD 7tyv D E 0 A | a protein | protein NA | NA glycoprotein g2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 02/14/22 Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C LASSA VIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa virus | lassa virus Enriquez, A.S., Hastie, K.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2qsc H L 0 P peptide envelope glycoprotein gp120 immune system 07/30/07 Crystal structure analysis of anti-HIV-1 V3-Fab F425-B4e8 in complex with a V3-peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bell, C.H., Schiefner, A., Stanfield, R.L., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.264 0.219 False True IGHV3 IGKV1 Kappa None None None None None 3oaz H L 0 IMMUNE SYSTEM 08/06/10 A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity HOMO SAPIENS homo sapiens homo sapiens Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G 1.75 X-RAY DIFFRACTION 0.217 0.176 False True IGHV3 IGKV1 Kappa None None None None None 5wob I J 0 A protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 6cdm A B 0 C peptide hiv fusion peptide (512-519) IMMUNE SYSTEM 02/08/18 Structure of vaccine-elicited HIV-1 neutralizing antibody vFP7.04 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.408 X-RAY DIFFRACTION 0.222 0.184 False True IGHV1 IGKV1 Kappa 8.050000000000001e-10 -12.406714218098521 Unknown TBD 3jbf 7 NA 0 3 protein capsid protein vp3 VIRUS/IMMUNE SYSTEM 08/26/15 Complex of poliovirus with VHH PVSP19B CAMELUS DROMEDARIUS; HUMAN POLIOVIRUS 1 MAHONEY camelus dromedarius human poliovirus 1 mahoney Strauss, M., Schotte, L., Thys, B., Filman, D.J., Hogle, J.M. 4.6 ELECTRON MICROSCOPY False True IGHV1 None None None None None 2xv6 B NA 0 A protein capsid protein p24 VIRAL PROTEIN/IMMUNE SYSTEM 10/22/10 Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH. HUMAN IMMUNODEFICIENCY VIRUS 1; VICUGNA PACOS vicugna pacos human immunodeficiency virus 1 Igonet, S., Vaney, M.-C., Bartonova, V., Helma, J., Rothbauer, U., Leonhardt, H., Stura, E., Krausslich, H.-G., Rey, F.A. 1.89 X-RAY DIFFRACTION 0.1952 0.1748 False True IGHV1 None None None None None 3i9g H L 0 L Hapten S1P (2S,3R,4E)-2-AMINO-3-HYDROXYOCTADEC-4-EN-1-YL DIHYDROGEN PHOSPHATE IMMUNE SYSTEM 07/10/09 Crystal structure of the LT1009 (SONEPCIZUMAB) antibody Fab fragment in complex with sphingosine-1-phosphate MUS MUSCULUS mus musculus mus musculus mus musculus Huxford, T. 1.9 X-RAY DIFFRACTION 0.219 0.190 False True IGHV5 IGKV1 Kappa 1.10e-09 -12.21 SPR 25 19815502 3mlv N M 0 Q peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with an NOF V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.48 X-RAY DIFFRACTION 0.342 0.233 False False IGHV5 IGLV3 Lambda None None None None None 2a77 H L 0 IMMUNE SYSTEM 07/04/05 Anti-Cocaine Antibody 7.5.21, Crystal Form II MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Ringe, D., Petsko, G.A. 1.8 X-RAY DIFFRACTION 0.263 0.218 False False IGHV5 IGKV1 Kappa None None None None None 7dpm J K 0 L protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/20/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M. 3.304 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGKV1 Kappa None None None None None 1cf8 H L 0 H Hapten HAZ 4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACID CATALYTIC ANTIBODY 03/24/99 Convergence of catalytic antibody and terpene cyclase mechanisms: polyene cyclization directed by carbocation-pi interactions MUS MUSCULUS mus musculus mus musculus mus musculus Paschall, C.M., Hasserodt, J., Jones, T., Lerner, R.A., Janda, K.D., Christianson, D.W. 2.7 X-RAY DIFFRACTION 0.257 0.165 False False IGHV3 IGKV4 Kappa None None None None None 5h32 G H 0 A protein structural protein e VIRUS/IMMUNE SYSTEM 10/20/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lok, S.-M. 12 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7rkm D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/22/21 Structure of CX3CL1-US28-Gi-scFv16 in C-state HOMO SAPIENS; MUS MUSCULUS; HUMAN BETAHERPESVIRUS 5 mus musculus homo sapiens | homo sapiens Tsutsumi, N., Qu, Q., Jude, K.M., Skiniotis, G., Garcia, K.C. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6qd6 E NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 6p3b H L 0 IMMUNE SYSTEM 05/23/19 Crystal structure of the anti-HIV antibody DH501 unmutated common ancestor (UCA) MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I., Saunders, K.O. 2.02 X-RAY DIFFRACTION 0.272 0.218 False True IGHV2 IGLV1 Lambda None None None None None 6ey6 I NA 0 A protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 6mjz H L 0 C | A | B protein | protein | protein NA | NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 | fusion glycoprotein f0 VIRAL PROTEIN/immune system 09/24/18 Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174 HUMAN PARAINFLUENZA VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens human parainfluenza virus 3 | human parainfluenza virus 3 | human parainfluenza virus 3 Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True IGHV4 IGKV1 Kappa None None None None None 1bql H L 0 Y protein bobwhite quail lysozyme ANTIBODY/ANTIGEN 02/03/95 STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME MUS MUSCULUS; COLINUS VIRGINIANUS mus musculus mus musculus colinus virginianus Chacko, S., Davies, D.R. 2.6 X-RAY DIFFRACTION 0.291 0.191 False True IGHV1 IGKV4 Kappa None None None None None 5cd5 C D 0 A protein 93th057 hiv-1 gp120 core IMMUNE SYSTEM 07/03/15 Crystal structure of an immature VRC01-class antibody DRVIA7 from a Chinese donor bound to clade A/E HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kong, L., Wilson, I.A. 3.396 X-RAY DIFFRACTION 0.306 0.253 False True unknown IGKV1 Kappa 2.89e-07 -8.920931468069222 SPR TBD 6x04 F NA 0 E protein NA nucleoporin nup133 STRUCTURAL PROTEIN 05/15/20 Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN5 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 2.68 X-RAY DIFFRACTION 0.261 0.244 False True IGHV1 NA NA None None None None None 1t4k D C 0 IMMUNE SYSTEM 04/29/04 Crystal Structure of Unliganded Aldolase Antibody 93F3 Fab MUS MUSCULUS mus musculus mus musculus Zhu, X., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.281 0.233 False False IGHV2 IGKV8 Kappa None None None None None 5tlj B A 0 X protein cd27 antigen IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 3.5 X-RAY DIFFRACTION 0.356 0.283 False True IGHV1 IGKV3 Kappa None None None None None 7pi3 M N 0 H protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 4xwo O P 0 M protein sec22 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 5f97 E NA 0 A protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group A type 1 hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.62 X-RAY DIFFRACTION 0.237 0.188 False True IGHV1 None None None None None 6wfz H L 0 P peptide NA npna3 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab399 in complex with NPNA3 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 1.84 X-RAY DIFFRACTION 0.225 0.186 False True IGHV3 IGKV2 Kappa None None None None None 4xh2 J K 0 j peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD4 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.0 X-RAY DIFFRACTION 0.258 0.224 False True IGHV3 IGKV1 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 43c9 F E 0 IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY MUS MUSCULUS mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.2 X-RAY DIFFRACTION 0.265 0.210 False True IGHV2 IGKV8 Kappa None None None None None 5udd N T 0 G protein NA fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F B9320 Bound to MEDI8897 HUMAN RESPIRATORY SYNCYTIAL VIRUS 9320; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus 9320 McLellan, J.S. 4.3 X-RAY DIFFRACTION 0.295 0.237 False True IGHV1 IGKV1 Kappa None None None None None 3cm9 D O 9 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6umg h l 0 c | r protein | protein NA | NA unknown | unknown MEMBRANE PROTEIN/IMMUNE SYSTEM 10/09/19 Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Mohr, C. 2.7 X-RAY DIFFRACTION 0.282 0.245 False False IGHV3 IGLV1 Lambda None None None None None 6xc3 H L 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.1 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 2.698 X-RAY DIFFRACTION 0.225 0.177 False True IGHV5 IGKV4 Kappa None None None None None 7mf9 H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA Fab in space group C2 HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 3.7 X-RAY DIFFRACTION 0.269 0.240 False True IGHV3 IGLV3 Lambda None None None None None 6e5p M K 0 M carbohydrate NAG polysaccharide VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens homo sapiens Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 5jny C D 0 IMMUNE SYSTEM 05/01/16 Crystal Structure of 10E8 Fab HOMO SAPIENS homo sapiens homo sapiens Ofek, G., Kwong, P. 3.041 X-RAY DIFFRACTION 0.215 0.188 False True IGHV3 IGLV3 Lambda None None None None None 4dke H L 0 A protein interleukin-34 CYTOKINE/IMMUNE SYSTEM 02/03/12 Crystal Structure of Human Interleukin-34 Bound to FAb1.1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ma, X., Chen, Y., Stawicki, S., Wu, Y., Bazan, J.F., Starovasnik, M.A. 3.0 X-RAY DIFFRACTION 0.265 0.231 False True IGHV3 IGKV1 Kappa 1.2e-10 -13.534418347189932 SPR TBD 7ul3 C NA 0 A protein NA histamine h2 receptor MEMBRANE PROTEIN 04/03/22 CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab Homo sapiens; synthetic construct synthetic construct homo sapiens Robertson, M.J., Skiniotis, G. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3auv B b 0 IMMUNE SYSTEM 02/16/11 Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface HOMO SAPIENS homo sapiens Yu, C.M., Peng, H.P., Chen, I.C., Lee, Y.C., Chen, J.B., Tsai, K.C., Chen, C.T., Chang, J.Y., Yang, E.W., Hsu, P.C., Jian, J.W., Hsu, H.J., Chang, H.J., Hsu, W.L., Huang, K.F., Ma, A.C., Yang, A.S. 2.4 X-RAY DIFFRACTION 0.251 0.216 True True unknown unknown unknown None None None None None 4k2u I M 0 B protein erythrocyte binding antigen 175 IMMUNE SYSTEM 04/09/13 Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Tolia, N.H. 2.45 X-RAY DIFFRACTION 0.253 0.204 False False IGHV14 IGKV10 Kappa 1.53e-11 -14.754720790655165 SPR TBD 7cvz Q R 0 H | G protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263 CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 6o24 A B 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4498 Fab in complex with circumsporozoite protein NANP3 and anti-Kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 1.4 X-RAY DIFFRACTION 0.186 0.161 False True IGHV3 IGKV3 Kappa None None None None None 2qad H G 0 E protein envelope glycoprotein gp160 viral protein/immune system 06/14/07 Structure of tyrosine-sulfated 412d antibody complexed with HIV-1 YU2 gp120 and CD4 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.-C., Tang, M., Robinson, J., Wyatt, R., Kwong, P.D. 3.3 X-RAY DIFFRACTION 0.269 0.202 False True IGHV1 IGKV1 Kappa None None None None None 7np9 C NA 0 NA NA NA NA IMMUNE SYSTEM 02/26/21 Structure of the human CR3 - CD11bCD18 specific nanobody hCR3Nb1 LAMA GLAMA lama glama Jensen, R.K., Andersen, G.R. 1.14 X-RAY DIFFRACTION 0.167 0.146 False True IGHV1 NA NA None None None None None 7t0g H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-39 Fab Unliganded 1 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 1.53 X-RAY DIFFRACTION 0.212 0.176 False True IGHV7 IGKV8 Kappa None None None None None 3l1o H L 0 IMMUNE SYSTEM 12/14/09 Crystal structure of monoclonal antibody MN423 Fab fragment with free combining site, crystallized in the presence of zinc MUS MUSCULUS mus musculus mus musculus Skrabana, R., Sevcik, J. 2.0 X-RAY DIFFRACTION 0.249 0.158 False False IGHV7 IGKV16 Kappa None None None None None 6idg H L 0 A nucleic-acid 64T 5-HYDROXY-THYMIDINE-5'-MONOPHOSPHATE IMMUNE SYSTEM 09/10/18 antibody 64M-5 Fab in complex with dT(6-4)T MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Yokoyama, H., Mizutani, R., Noguchi, S., Hayashida, N. 2.0 X-RAY DIFFRACTION 0.240 0.192 False False IGHV1 IGKV1 Kappa None None None None None 7kn6 C NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH V and antibody Fab CC12.3 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS; HOMO SAPIENS vicugna pacos severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.55 X-RAY DIFFRACTION 0.239 0.193 False True IGHV1 NA NA None None None None None 5mv4 A B 0 X peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 1kir B A 0 C protein lysozyme COMPLEX (IMMUNOGLOBULIN/HYDROLASE) 10/23/96 FV MUTANT Y(A 50)S (VL DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Fields, B.A., Poljak, R.J., Mariuzza, R.A. 2.0 X-RAY DIFFRACTION unknown 0.167 False True IGHV2 IGKV12 Kappa None None None None None 6dbg C NA 0 B protein internalin b IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R303 in complex with InlB-LRR-IR LISTERIA MONOCYTOGENES; CAMELUS DROMEDARIUS camelus dromedarius listeria monocytogenes Brooks, C.L., Toride King, M., Huh, I. 1.51 X-RAY DIFFRACTION 0.180 0.160 False True IGHV1 None None None None None 6d6u K L 0 D protein gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 04/22/18 Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, S., Noviello, C.M., Teng, J., Walsh Jr, R.M., Kim, J.J., Hibbs, R.E. 3.8 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa 6.1e-09 -11.20681521904132 Unknown TBD 7ws7 K J 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Guo, H., Gao, Y., Ji, X., Yang, H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ch4 H L 0 R protein NA spike glycoprotein PROTEIN BINDING/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-604 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 3.15 X-RAY DIFFRACTION 0.273 0.225 False True IGHV3 IGKV1 Kappa None None None None None 2kh2 B b 46 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7rd4 A B 0 I peptide NA circumsporozoite protein IMMUNE SYSTEM 07/09/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.149 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 1.75 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV4 Kappa None None None None None 3qeh G H 0 IMMUNE SYSTEM 01/20/11 Crystal structure of human N12-i15, an ADCC and non-neutralizing anti-HIV-1 Env antibody HOMO SAPIENS homo sapiens homo sapiens Guan, Y., DeVico, A.L., Lewis, G.K., Pazgier, M. 2.59 X-RAY DIFFRACTION 0.254 0.216 False False IGHV1 IGKV2 Kappa None None None None None 5uk4 h NA 0 H protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 2zjs H L 0 Y protein preprotein translocase secy subunit PROTEIN TRANSPORT/IMMUNE SYSTEM 03/08/08 Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment THERMUS THERMOPHILUS; MUS MUSCULUS mus musculus mus musculus thermus thermophilus Tsukazaki, T., Mori, H., Fukai, S., Ishitani, R., Perederina, A., Vassylyev, D.G., Ito, K., Nureki, O. 3.2 X-RAY DIFFRACTION 0.280 0.244 False True IGHV1 IGKV10 Kappa None None None None None 7m51 H L 0 A peptide NA spike glycoprotein stem helix peptide ANTIVIRAL PROTEIN, IMMUNE SYSTEM 03/22/21 B6 Fab fragment bound to the OC43 spike stem helix peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human coronavirus oc43 Sauer, M.M., Park, Y.J., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.8 X-RAY DIFFRACTION 0.230 0.182 False True IGHV1 IGKV8 Kappa None None None None None 3auv E e 0 IMMUNE SYSTEM 02/16/11 Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface HOMO SAPIENS homo sapiens Yu, C.M., Peng, H.P., Chen, I.C., Lee, Y.C., Chen, J.B., Tsai, K.C., Chen, C.T., Chang, J.Y., Yang, E.W., Hsu, P.C., Jian, J.W., Hsu, H.J., Chang, H.J., Hsu, W.L., Huang, K.F., Ma, A.C., Yang, A.S. 2.4 X-RAY DIFFRACTION 0.251 0.216 True True unknown unknown unknown None None None None None 1i3g H L 0 ANTIBIOTIC 02/15/01 CRYSTAL STRUCTURE OF AN AMPICILLIN SINGLE CHAIN FV, FORM 1, FREE MUS MUSCULUS mus musculus mus musculus Jung, S., Spinelli, S., Schimmele, B., Honegger, A., Pugliese, L., Cambillau, C., Pluckthun, A. 2.44 X-RAY DIFFRACTION 0.243 0.175 False True IGHV1 IGKV6 Kappa None None None None None 6az2 C E 0 D protein histone chaperone asf1 IMMUNE SYSTEM 09/09/17 Crystal structure of Asf1-Fab 12E complex HOMO SAPIENS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C) homo sapiens homo sapiens saccharomyces cerevisiae (strain atcc 204508 /s288c) Bailey, L.J., Kossiakoff, A.A. 2.477 X-RAY DIFFRACTION 0.228 0.193 False True IGHV3 IGKV1 Kappa None None None None None 7neh H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/04/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 1.77 X-RAY DIFFRACTION 0.198 0.188 False True IGHV3 IGKV1 Kappa None None None None None 6nmr F G 0 I protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.42 X-RAY DIFFRACTION 0.323 0.289 False True IGHV3 IGKV3 Kappa None None None None None 1nbv H L 0 IMMUNOGLOBULIN 03/16/93 AN AUTOANTIBODY TO SINGLE-STRANDED DNA: COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE-FAB COMPLEX MUS MUSCULUS mus musculus mus musculus Herron, J.N., He, X.M., Edmundson, A.B. 2.0 X-RAY DIFFRACTION unknown 0.246 False True IGHV10 IGKV1 Kappa None None None None None 2mkw NA A 13 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 3ria F N 0 B protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.8 X-RAY DIFFRACTION 0.280 0.266 False True IGHV1 IGLV1 Lambda None None None None None 5uek H L 0 A protein histone chaperone asf1 IMMUNE SYSTEM 01/02/17 Structure of antigen-Fab 12E complex with Histone chaperone ASF1 SACCHAROMYCES CEREVISIAE; HOMO SAPIENS homo sapiens homo sapiens saccharomyces cerevisiae Bailey, L.J., Kossiakoff, A.A. 1.7 X-RAY DIFFRACTION 0.213 0.176 False True IGHV3 IGKV1 Kappa None None None None None 7n9v L NA 0 A protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/21 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Tripler, T.N. 3.45 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 NA NA None None None None None 3ixy I J 0 B protein envelope protein e VIRUS 02/26/09 The pseudo-atomic structure of dengue immature virus in complex with Fab fragments of the anti-fusion loop antibody E53 DENGUE VIRUS 2; MUS MUSCULUS mus musculus mus musculus dengue virus 2 Cherrier, M.V., Kaufmann, B., Nybakken, G.E., Lok, S.M., Warren, J.T., Nelson, C.A., Kostyuchenko, V.A., Holdaway, H.A., Chipman, P.R., Kuhn, R.J., Diamond, M.S., Rossmann, M.G., Fremont, D.H. 23 ELECTRON MICROSCOPY False True IGHV7 IGKV4 Kappa None None None None None 7mep H L 0 A protein NA bg505 sosipv5.2(7s) - gp120 VIRAL PROTEIN 04/07/21 BG505 SOSIP.v5.2(7S) in complex with the monoclonal antibodies Rh.33172 mAb.1 and RM19R MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS macaca mulatta macaca mulatta human immunodeficiency virus Antanasijevic, A., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5w1k T S 0 R protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV3 IGKV1 Kappa None None None None None 6nc3 Q V 0 K | E protein | protein NA | NA hiv-1 env amc011 v4.2 sosip gp41 | hiv-1 env amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Torres, J.L., Ward, A.B. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6wn4 A B 0 C peptide NA lipoprotein lipase peptide IMMUNE SYSTEM 04/22/20 Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Luz, J.G., Birrane, G., Young, S.G., Meiyappan, M., Ploug, M. 2.8 X-RAY DIFFRACTION 0.243 0.208 False False IGHV1 IGKV4 Kappa None None None None None 5any K O 0 F | E protein | protein NA | NA e2 | e1 VIRUS 09/08/15 Electron cryo-microscopy of chikungunya virus in complex with neutralizing antibody Fab CHK265 CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Fox, J.M., Long, F., Edeling, M.A., Lin, H., Duijl-Richter, M., Fong, R.H., Kahle, K.M., Smit, J.M., Jin, J., Simmons, G., Doranz, B.J., Crowe, J.E., Fremont, D.H., Rossmann, M.G., Diamond, M.S. 16.9 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 6qb6 H L 0 A protein induced myeloid leukemia cell differentiation protein mcl-1 APOPTOSIS 12/20/18 Mcl1 in complex with a Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hargreaves, D. 2.24 X-RAY DIFFRACTION 0.232 0.187 False True IGHV3 IGLV1 Lambda None None None None None 1bzq N NA 0 B protein protein (rnase a) HYDROLASE/IMMUNE SYSTEM 11/03/98 COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Decanniere, K., Desmyter, A., Gahroudhi, M., Lauwereys, M., Muyldermans, S., Wyns, L. 2.8 X-RAY DIFFRACTION 0.282 0.222 False True IGHV1 None None None None None 3zkm H L 0 A protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 01/23/13 BACE2 FAB COMPLEX HOMO SAPIENS; MUS MUSCULUS homo sapiens mus musculus homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 1.85 X-RAY DIFFRACTION 0.24545 0.21077 False True IGHV2 IGKV3 Kappa None None None None None 2mmx NA A 12 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6wk4 A B 0 NA NA NA NA IMMUNE SYSTEM 04/15/20 Fab Fragment of Anti-human LAG3 antibody (13E2) MUS MUSCULUS mus musculus mus musculus Agnihotri, P., Mishra, A.K., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.228 0.186 False True IGHV8 IGKV6 Kappa None None None None None 6woz K L 0 J protein NA reticulocyte binding protein 2b CELL INVASION 04/26/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 251249 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.258 0.211 False True IGHV3 IGKV3 Kappa None None None None None 7kfb G J 0 A protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442 EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5xcr A B 0 C peptide c8 peptide IMMUNE SYSTEM 03/23/17 Crystal structure of P20.1 Fv-clasp fragment with its antigen peptide MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 1.75 X-RAY DIFFRACTION 0.202 0.171 False True IGHV9 IGLV1 Lambda None None None None None 7c4s J K 0 B protein NA sphingosine 1-phosphate receptor 3 MEMBRANE PROTEIN 05/18/20 Sphingosine-1-phosphate receptor 3 with a natural ligand. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Iwata, S., Maeda, S., Luo, F., Nango, E., hirata, K., Asada, H. 3.2 X-RAY DIFFRACTION 0.263 0.242 False False IGHV1 IGKV6 Kappa None None None None None 7f2s A B 0 NA NA NA NA IMMUNE SYSTEM 06/14/21 Crystal structure of anti S-gatifloxacin antibody Fab fragment apo form MUS MUSCULUS mus musculus mus musculus Wang, L.T., Jiao, W.Y., Shen, X., Lei, H.T. 2.62 X-RAY DIFFRACTION 0.278 0.247 False False IGHV1 IGKV3 Kappa None None None None None 1xcq F E 0 P | N peptide | protein NA | NA capsid protein c | protein l IMMUNE SYSTEM 09/03/04 Complex HCV core-Fab 19D9D6-Protein L mutant (D55A,L57H,Y64W) in space group P21 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | finegoldia magna Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 3.5 X-RAY DIFFRACTION 0.264 0.192 False False IGHV9 IGKV8 Kappa None None None None None 7kji A NA 0 B protein NA surface protein p12p UNKNOWN FUNCTION 10/26/20 Plasmodium falciparum protein Pf12p bound to nanobody D9 VICUGNA PACOS; PLASMODIUM FALCIPARUM vicugna pacos plasmodium falciparum Dietrich, M.H., Tham, W.H. 3.25 X-RAY DIFFRACTION 0.286 0.245 False True IGHV1 NA NA None None None None None 3hfm H L 0 Y protein hen egg white lysozyme COMPLEX(ANTIBODY-ANTIGEN) 08/11/88 STRUCTURE OF AN ANTIBODY-ANTIGEN COMPLEX. CRYSTAL STRUCTURE OF THE HY/HEL-10 FAB-LYSOZYME COMPLEX MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Padlan, E.A., Davies, D.R. 3.0 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV5 Kappa None None None None None 4c59 B NA 0 A protein cyclin-g-associated kinase TRANSFERASE 09/10/13 Structure of GAK kinase in complex with nanobody (NbGAK_4) HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S. 2.8 X-RAY DIFFRACTION 0.26163 0.20238 False False IGHV1 None None None None None 6wh9 E F 0 D protein NA kr1 OXIDOREDUCTASE/IMMUNE SYSTEM 04/07/20 Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Mathews, I.I., Khosla, C. 2.75 X-RAY DIFFRACTION 0.271 0.228 False True IGHV1 IGLV7 Lambda None None None None None 2ny7 H L 0 G protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.255 0.193 False True IGHV1 IGKV3 Kappa 3.64e-08 SPR 17301785 6w7s H L 0 A protein NA eryai OXIDOREDUCTASE/IMMUNE SYSTEM 03/19/20 Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 2G10 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Mathews, I.I., Khosla, C. 2.25 X-RAY DIFFRACTION 0.232 0.179 False True IGHV3 IGLV5 Lambda None None None None None 5vl2 D NA 0 D Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 4xgz E F 0 e peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 2gfb P O 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 3chn C O 6 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7ar0 B NA 0 A protein NA variant surface glycoprotein mitat 1.2 MEMBRANE PROTEIN 10/23/20 Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB19) LAMA GLAMA; TRYPANOSOMA BRUCEI BRUCEI lama glama trypanosoma brucei brucei Stebbins, C.E., Hempelmann, A. 2.139 X-RAY DIFFRACTION 0.234 0.206 False True IGHV1 NA NA None None None None None 2hlf E F 0 B protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 07/07/06 Structure of the Escherichis coli ClC chloride channel Y445E mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.3 X-RAY DIFFRACTION 0.309 0.281 False False IGHV4 IGKV4 Kappa None None None None None 7ws4 I H 0 C | A | B protein | protein | protein NA | NA | NA spike glycoprotein | spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5ojm O NA 0 E protein human gabaa receptor chimera beta3-alpha5,gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 07/21/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 SYNTHETIC CONSTRUCT; HOMO SAPIENS; LAMA GLAMA lama glama synthetic construct, homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.3 X-RAY DIFFRACTION 0.250 0.234 False True IGHV1 None None None None None 5xrq H L 0 IMMUNE SYSTEM 06/09/17 Crystal structure of human monoclonal antibody H3v-47 HOMO SAPIENS homo sapiens homo sapiens Zhang, H., Willson, I.A. 2.6 X-RAY DIFFRACTION 0.214 0.180 False True IGHV1 IGKV3 Kappa None None None None None 7e8c K I 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7mlu F K 0 E protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7n0v H L 0 C protein NA major pollen allergen bet v 1-a ALLERGEN 05/26/21 Complex of recombinant Bet v 1 with Fab fragment of REGN5715 MUS MUSCULUS; BETULA PENDULA mus musculus mus musculus betula pendula Franklin, M.C., Romero Hernandez, A. 3.71 X-RAY DIFFRACTION 0.378 0.327 False True IGHV1 IGKV3 Kappa None None None None None 5w4l H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 06/12/17 Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in complex with HIV-1 clade A/E gp120, the CD4 mimetic M48U1, and the antibody N5-i5. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 2.92 X-RAY DIFFRACTION 0.292 0.231 False True IGHV3 IGLV2 Lambda None None None None None 6xq4 C B 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S8V2-47 in complex with the influenza hemagglutinin head domain of A/Beijing/262/1995(H1N1) INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) McCarthy, K.R., Harrison, S.C. 3.347 X-RAY DIFFRACTION 0.279 0.238 False True IGHV3 IGKV4 Kappa None None None None None 1yuh H L 0 H Hapten NP 4-HYDROXY-3-NITROPHENYLACETYL-EPSILON-AMINOCAPROIC ACID IMMUNOGLOBULIN 01/30/96 FAB FRAGMENT MUS MUSCULUS mus musculus Yuhasz, S.C., Amzel, L.M., Parry, C., Strand, M. 3.0 X-RAY DIFFRACTION unknown 0.190 False True IGHV1 IGLV1 Lambda None None None None None 6wh9 H I 0 A protein NA kr1 OXIDOREDUCTASE/IMMUNE SYSTEM 04/07/20 Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Mathews, I.I., Khosla, C. 2.75 X-RAY DIFFRACTION 0.271 0.228 False True IGHV1 IGLV7 Lambda None None None None None 3l7e H L 0 IMMUNE SYSTEM 12/28/09 Crystal structure of ANTI-IL-13 antibody C836 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.5 X-RAY DIFFRACTION 0.251 0.201 False True IGHV8 IGKV16 Kappa None None None None None 7s6d E G 0 A protein NA 6-deoxyerythronolide-b synthase erya2, modules 3 and 4,lsd14 polyketide synthase fusion BIOSYNTHETIC PROTEIN 09/13/21 CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES LASALOCIDI; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea, streptomyceslasalocidi Bagde, S.R., Kim, C.-Y., Fromme, J.C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7k7y H NA 0 G protein NA botulinum neurotoxin type e ANTITOXIN 09/24/20 Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 3.6 X-RAY DIFFRACTION 0.288 0.261 False True IGHV1 NA NA None None None None None 2x7l A B 0 O protein hiv rev IMMUNE SYSTEM 03/01/10 Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element UNCLASSIFIED; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 BH10 unclassified unclassified human immunodeficiency virus type 3 DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M. 3.17 X-RAY DIFFRACTION 0.2500 0.2337 False True IGHV1 IGKV1 Kappa None None None None None 6bf7 E F 0 B protein insulin-degrading enzyme HYDROLASE/IMMUNE SYSTEM 10/26/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 6.5 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 2aj3 B A 0 IMMUNE SYSTEM 08/01/05 Crystal Structure of a Cross-Reactive HIV-1 Neutralizing CD4-Binding Site Antibody Fab m18 HOMO SAPIENS homo sapiens homo sapiens Prabakaran, P., Gan, J., Wu, Y.Q., Zhang, M.Y., Dimitrov, D.S., Ji, X. 2.03 X-RAY DIFFRACTION 0.269 0.225 False True IGHV4 IGKV1 Kappa None None None None None 6gkd N NA 0 L protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 6vi1 L K 0 R peptide NA terminase, large subunit IMMUNE SYSTEM 01/11/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 2.4 X-RAY DIFFRACTION 0.239 0.189 False True IGHV3 IGKV1 Kappa None None None None None 6ui1 D NA 0 A protein bont/a TOXIN/ANTITOXIN 09/29/19 Crystal structure of BoNT/A-LCHn domain in complex with VHH ciA-D12, ciA-B5, and ciA-H7 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.20001 X-RAY DIFFRACTION 0.229 0.181 False True IGHV1 None None None None None 5i1h H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-53/IGKV3-20 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.222 X-RAY DIFFRACTION 0.266 0.229 False True IGHV3 IGKV3 Kappa None None None None None 6a78 H L 0 A protein roundabout homolog 1 IMMUNE SYSTEM 07/02/18 Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the scFv fragment of murine monoclonal antibody B5209B HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mizohata, E., Nakayama, T., Kado, Y., Inoue, T. 2.1 X-RAY DIFFRACTION 0.285 0.239 False True IGHV5 IGKV12 Kappa None None None None None 6zcz F NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 06/12/20 Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in ternary complex with EY6A Fab and a nanobody. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; HOMO SAPIENS lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 2.65 X-RAY DIFFRACTION 0.260 0.215 False True IGHV1 NA NA None None None None None 6gff L K 0 I | C | D protein | protein | protein NA | NA | NA leucine-rich repeat-containing protein 32 | transforming growth factor beta-1 | transforming growth factor beta-1 IMMUNE SYSTEM 04/30/18 Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens | homo sapiens Merceron, R., Lienart, S., Vanderaa, C., Colau, D., Stockis, J., Van Der Woning, B., De Haard, H., Saunders, M., Coulie, P.G., Savvides, S.N., Lucas, S. 3.1 X-RAY DIFFRACTION 0.268 0.233 False False IGHV2 IGKV13 Kappa None None None None None 7now A NA 0 B protein NA nuclear pore complex protein nup96 NUCLEAR PROTEIN 02/26/21 Complex of Nucleoporin-98 and nanobody MS98-27 solved at 1.85A resolution VICUGNA PACOS; XENOPUS TROPICALIS vicugna pacos xenopus tropicalis Sola-Colom, M., Trakhanov, S., Goerlich, D. 1.85 X-RAY DIFFRACTION 0.209 0.184 False True IGHV1 NA NA None None None None None 6n8d F E 0 C protein major capsid protein IMMUNE SYSTEM 11/29/18 Crystal structure of GII.4 2002 norovirus P domain in complex with neutralizing human antibody A1431 NOROVIRUS HU/GII.4/FARMINGTON HILLS/2004/USA; HOMO SAPIENS homo sapiens homo sapiens norovirus hu/gii.4/farmington hills/2004/usa Changela, A., Verardi, R., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.227 0.176 False True IGHV3 IGKV3 Kappa None None None None None 4z5r K J 0 D protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 6qx4 D NA 0 A protein s-layer protein sap STRUCTURAL PROTEIN 03/07/19 Structure of the Bacillus anthracis Sap S-layer assembly domain BACILLUS ANTHRACIS; LAMA GLAMA lama glama bacillus anthracis Remaut, H., Fioravanti, A. 3.27 X-RAY DIFFRACTION 0.218 0.173 False True IGHV3 None None None None None 7z0y H L 0 R protein NA spike protein s1 ANTIVIRAL PROTEIN, IMMUNE SYSTEM 02/23/22 THSC20.HVTR04 Fab bound to SARS-CoV-2 Receptor Binding Domain HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wibmer, C.K. 2.95 X-RAY DIFFRACTION 0.241 0.219 False True IGHV3 IGLV2 Lambda None None None None None 6dfi H L 0 E protein zika virus envelope protein diii IMMUNE SYSTEM 05/14/18 Crystal structure of anti-Zika antibody Z021 bound to Zika virus envelope protein DIII HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Keeffe, J.R., Bjorkman, P.J. 2.48 X-RAY DIFFRACTION 0.229 0.182 False True IGHV4 IGKV3 Kappa None None None None None 5nm0 A NA 0 IMMUNE SYSTEM 04/05/17 Nb36 Ser85Cys with Hg, crystal form 1 LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 1.5 X-RAY DIFFRACTION 0.211 0.189 False True IGHV1 None None None None None 7a0y C D 0 A protein NA na(+)/h(+) antiporter nhaa MEMBRANE PROTEIN 08/11/20 Structure of dimeric sodium proton antiporter NhaA K300R variant, at pH 8.2, crystallized with chimeric Fab antibodies SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM STR. LT2; GALLUS GALLUS; HOMO SAPIENS gallus gallus, homo sapiens gallus gallus, homo sapiens salmonella enterica subsp. enterica serovartyphimurium str. lt2 Fippel, A., Mir, S.H., Lentes, C.J., Wirth, C., Hunte, C. 2.45 X-RAY DIFFRACTION 0.241 0.203 False True unknown unknown unknown None None None None None 4k23 H L 0 IMMUNE SYSTEM 04/08/13 Structure of anti-uPAR Fab ATN-658 MUS MUSCULUS mus musculus mus musculus Yuan, C., Huang, M., Chen, L. 1.6 X-RAY DIFFRACTION 0.246 0.198 False False IGHV1 IGKV1 Kappa None None None None None 2bx5 NA L 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 7kc1 H L 0 B | A protein | protein NA | NA fusion protein of hemagglutinin and envelope glycoprotein | hemagglutinin IMMUNE SYSTEM 10/04/20 Cryo-EM structure of SRR2899884.46167H+MEDI8852L fab in complex with Victoria HA INFLUENZA A VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens influenza a virus, human immunodeficiency virus1 | influenza a virus Gorman, J., Kwong, P.D. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV1 Kappa None None None None None 3ngb B C 0 A protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/10 Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.68 X-RAY DIFFRACTION 0.256 0.197 False True IGHV1 IGKV3 Kappa 7.70e-09 -10.88 SPR 20 20616231 7det D d 0 C protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 11/05/20 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y., Zhang, G., Li, X., Rao, Z., Guo, Y. 2.2 X-RAY DIFFRACTION 0.260 0.212 True True unknown unknown unknown None None None None None 5jpj NA A 0 IMMUNE SYSTEM 05/03/16 Crystal structure of 6aJL2-R24G HOMO SAPIENS homo sapiens Pelaez-Aguilar, A.E., Diaz-Vilchis, A., Amero, C., Becerril, B., Rudino-Pinera, E. 2.0 X-RAY DIFFRACTION 0.249 0.195 False True IGLV6 Lambda None None None None None 7ns6 U NA 0 K protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/05/21 SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4 vicugna pacos severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Das, H., Hallberg, B.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6wds H L 0 C | A | B protein | protein | protein NA | NA | NA viral protein 3 | viral protein 1 | viral protein 2 VIRUS/IMMUNE SYSTEM 04/01/20 Enterovirus D68 in complex with human monoclonal antibody EV68-159 HOMO SAPIENS; ENTEROVIRUS D68 homo sapiens homo sapiens enterovirus d68 | enterovirus d68 | enterovirus d68 Fu, J., Klose, T., Vogt, M.R., Crowe, J.E., Rossmann, M.G., Kuhn, R.J., Center for Structural Genomics of Infectious Diseases (CSGID) 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 2ibz X Y 0 E protein ubiquinol-cytochrome c reductase iron-sulfursubunit, mitochondrial precursor OXIDOREDUCTASE 09/12/06 Yeast Cytochrome BC1 Complex with Stigmatellin MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Hunte, C. 2.3 X-RAY DIFFRACTION 0.256 0.222 False True IGHV3 IGKV10 Kappa None None None None None 6y1r E NA 0 NA NA NA NA IMMUNE SYSTEM 02/13/20 Nb22-LBT LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.85 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 NA NA None None None None None 4tsa H L 0 A protein lysozyme c Immune System/hydrolase 06/18/14 Structure of a lysozyme FAb complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Wensley, B. 2.27 X-RAY DIFFRACTION 0.310 0.281 False True IGHV3 IGLV1 Lambda None None None None None 3g6j H G 0 D | C protein | protein NA | NA complement c3 alpha chain | complement c3 beta chain IMMUNE SYSTEM 02/06/09 C3b in complex with a C3b specific Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Wiesmann, C. 3.1 X-RAY DIFFRACTION 0.282 0.214 False True IGHV3 IGKV1 Kappa 1.90e-09 -11.89 SPR 25 19196712 6qkd J NA 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGHV1 None None None None None 5hi3 H L 0 B protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 2.15 X-RAY DIFFRACTION 0.231 0.197 False True IGHV3 IGLV6 Lambda None None None None None 4kuc F E 0 I protein ricin HYDROLASE/IMMUNE SYSTEM 05/21/13 Crystal structure of ricin-A chain in complex with the antibody 6C2 RICINUS COMMUNIS; MUS MUSCULUS mus musculus mus musculus ricinus communis Zhu, Y., Li, X., Teng, M. 2.787 X-RAY DIFFRACTION 0.289 0.238 False True IGHV1 IGKV3 Kappa None None None None None 1p2c E D 0 F protein lysozyme c IMMUNE SYSTEM/HYDROLASE 04/15/03 crystal structure analysis of an anti-lysozyme antibody MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Cauerhff, A., Goldbaum, F.A., Braden, B.C. 2.0 X-RAY DIFFRACTION 0.242 0.204 False False IGHV1 IGKV5 Kappa 9.80e-11 -13.65 SPR 25 14988501 6fla A B 0 G protein domain iii of dengue virus 2 VIRAL PROTEIN 01/25/18 3H5 Fab bound to EDIII of DenV 2 Xtal form 1 MUS MUSCULUS; DENGUE VIRUS 2 mus musculus mus musculus dengue virus 2 Flanagan, A., Renner, M., Grimes, J.M. 2.9 X-RAY DIFFRACTION 0.221 0.203 False True IGHV1 IGKV3 Kappa None None None None None 4h8w H L 0 G protein hiv-1 clade a/e 93th057 (h375s) gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/24/12 Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tolbert, W.D., Acharya, P., Kwong, P.D., Pazgier, M. 1.85 X-RAY DIFFRACTION 0.215 0.182 False True IGHV3 IGLV2 Lambda None None None None None 5njd R Q 0 C | D protein | protein NA | NA interleukin-12 subunit beta | interleukin-23 subunit alpha IMMUNE SYSTEM 03/28/17 Structure of Interleukin 23 in complex with Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Bloch, Y., Savvides, S.N. 3.9 X-RAY DIFFRACTION 0.312 0.272 False True IGHV3 IGLV1 Lambda None None None None None 3bpc B A 0 B carbohydrate KDA (3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID)-2-O-ALLYL IMMUNE SYSTEM 12/18/07 co-crystal structure of S25-2 Fab in complex with 5-deoxy-4-epi-2,3-dehydro Kdo (4.8) Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 1.85 X-RAY DIFFRACTION 0.273 0.224 False False IGHV7 IGKV8 Kappa 1.6e-05 -6.5427509671824025 Unknown TBD 3o6l H L 0 C peptide protein tat 15-mer peptide IMMUNE SYSTEM 07/29/10 Anti-Tat HIV 11H6H1 Fab' complexed with a 15-mer Tat peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Serriere, J., Gouet, P., Guillon, C. 2.1 X-RAY DIFFRACTION 0.227 0.186 False False IGHV5 IGKV1 Kappa 3.10e-08 -9.93 Other 16 21035463 3j7e H L 0 IMMUNE SYSTEM 06/23/14 Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments MUS MUSCULUS mus musculus mus musculus Lee, H., Brendle, S.A., Bywaters, S.M., Christensen, N.D., Hafenstein, S. 13.6 ELECTRON MICROSCOPY False False IGHV1 IGKV8 Kappa None None None None None 2fjf D C 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 6ol7 P O 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV5 IGKV8 Kappa None None None None None 6dsi A a 0 IMMUNE SYSTEM 06/14/18 Anti recombinant prolactin receptor scFv HOMO SAPIENS homo sapiens Langley, D.B., Rouet, R., Christ, D. 2.49 X-RAY DIFFRACTION 0.245 0.207 True True unknown unknown unknown None None None None None 7lqv Y Z 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/15/21 Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gorman, J., Rapp, M., Kwong, P.D., Shapiro, L. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 7e88 G H 0 I protein NA spike protein s1 VIRAL PROTEIN,IMMUNE SYSTEM 03/01/21 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-515 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, C., Wei, Y., Xiao, J. 3.14 X-RAY DIFFRACTION 0.255 0.217 False True IGHV3 IGKV1 Kappa None None None None None 4rdq O N 0 D protein bestrophin-1 TRANSPORT PROTEIN 09/19/14 Calcium-activated chloride channel bestrophin-1, from chicken, in complex with Fab antibody fragments, chloride and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Dickson, V.K., Pedi, L., Long, S.B. 2.85 X-RAY DIFFRACTION 0.234 0.217 False False IGHV1 IGKV12 Kappa 1.5000000000000002e-08 -10.67372125591851 Unknown TBD 6a9k H L 0 H Hapten 9T0 5-[(2R,3R)-2-[2,2-bis(chloranyl)ethanoylamino]-3-(4-nitrophenyl)-3-[oxidanyl-[[4-[2,2,2-tris(fluoranyl)ethanoylamino]phenyl]methyl]phosphoryl]oxy-propoxy]-5-oxidanylidene-pentanoic acid IMMUNE SYSTEM 07/13/18 Crystal structure of the complex of the hydrolytic antibody Fab 9C10 with a transition-state analog MUS MUSCULUS mus musculus mus musculus mus musculus Tsuchiya, Y., Fujii, I., Tada, T., Yamaguchi, A., Tsumuraya, T., Kumon, A. 1.9 X-RAY DIFFRACTION 0.249 0.194 False False IGHV5 IGKV1 Kappa None None None None None 6iyn A NA 19 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7rkx D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/22/21 Structure of US27-Gi-scFv16 in CL-state HOMO SAPIENS; MUS MUSCULUS; HUMAN CYTOMEGALOVIRUS mus musculus homo sapiens | homo sapiens Tsutsumi, N., Jude, K.M., Garcia, K.C. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6gkd T NA 0 R protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 5c9k NA E 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 6xgc M N 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain ANTIVIRAL PROTEIN 06/17/20 CryoEM structure of influenza hemagglutinin A/Michigan/45/2015 in complex with cyno antibody 1C4 INFLUENZA A VIRUS (A/MICHIGAN/45/2015(H1N1)); MACACA FASCICULARIS macaca fascicularis macaca fascicularis influenza a virus (a/michigan/45/2015(h1n1)) | influenza a virus (a/michigan/45/2015(h1n1)) Qiu, Y., Zhou, Y. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 5yd4 C c 0 D peptide epitope peptide (mutation t6a) IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide (mutation T6A) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.173 0.135 True True unknown unknown unknown None None None None None 6apq A NA 0 IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody B LAMA GLAMA lama glama Taylor, A.B., Garza, J.A. 1.9 X-RAY DIFFRACTION 0.217 0.185 False True IGHV1 None None None None None 4jpi A B 0 IMMUNE SYSTEM 03/19/13 Crystal structure of a putative VRC01 germline precursor Fab HOMO SAPIENS Julien, J.-P., Diwanji, D.C., Jardine, J., Schief, W.R., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.214 0.175 False True IGHV1 IGKV3 Kappa None None None None None 7rnn C NA 0 D protein NA acid-sensing ion channel 1 MEMBRANE PROTEIN 07/29/21 Human ASIC1a-Nb.C1 complex VICUGNA PACOS; HOMO SAPIENS vicugna pacos homo sapiens Wu, Y., Chen, Z., Sigworth, F.J., Canessa, C.M. 2.86 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2c1p H L 0 H Hapten FNZ 4-[(1S,2R)-3-(4-FLUOROPHENYL)-2-HYDROXY-1-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]BENZONITRILE IMMUNE SYSTEM 09/19/05 Fab-fragment of enantioselective antibody complexed with finrozole MUS MUSCULUS mus musculus mus musculus mus musculus Parkkinen, T., Nevanen, T., Koivula, A., Rouvinen, J. 2.0 X-RAY DIFFRACTION 0.2853 0.2302 False True IGHV1 IGKV1 Kappa 4e-06 -7.3641077518219635 Unknown TBD 6k5d C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/28/19 Crystal structure of the E148N mutant CLC-ec1 in presence of 200 mM NaBr ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Park, K., Lim, H.H. 3.203 X-RAY DIFFRACTION 0.262 0.215 False True IGHV4 IGKV4 Kappa None None None None None 7sfv Q R 0 H protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 6dzn H L 0 IMMUNE SYSTEM 07/05/18 Pan-ebolavirus human antibody ADI-15878 Fab HOMO SAPIENS homo sapiens homo sapiens Murin, C.D., Ward, A.B., Bruhn, J.F., Stanfield, R. 2.1 X-RAY DIFFRACTION 0.265 0.224 False True IGHV3 IGKV1 Kappa None None None None None 4x8j H L 0 IMMUNE SYSTEM 12/10/14 Crystal Structure of murine 12F4 Fab monoclonal antibody against ADAMTS5 MUS MUSCULUS mus musculus mus musculus Larkin, J., Lohr, T.A., Elefante, L., Shearin, J., Matico, R., Su, J.-L., Xue, Y., Liu, F., Genell, C., Miller, R.E., Tran, P.B., Malfait, A.-M., Maier, C.C., Matheny, C.J. 2.35 X-RAY DIFFRACTION 0.234 0.217 False True IGHV6 IGKV6 Kappa None None None None None 7x2c E NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/25/22 Cryo-EM structure of the fenoldopam-bound D1 dopamine receptor and mini-Gs complex Homo sapiens; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Teng, X., Zheng, S. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5nm0 C NA 0 IMMUNE SYSTEM 04/05/17 Nb36 Ser85Cys with Hg, crystal form 1 LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 1.5 X-RAY DIFFRACTION 0.211 0.189 False True IGHV1 None None None None None 2ltq C B 6 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 3b2u H L 0 A protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 4rfe C D 0 IMMUNE SYSTEM 09/25/14 Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab MACACA MULATTA macaca mulatta macaca mulatta Wu, X., Gohain, N., Tolbert, W.D., Pazgier, M. 1.91 X-RAY DIFFRACTION 0.246 0.192 False True IGHV4 IGLV1 Lambda None None None None None 7kfb H K 0 B protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442 EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4zff H L 0 D protein vascular endothelial growth factor a SIGNALING PROTEIN/IMMUNE SYSTEM 04/21/15 Dual-acting Fab 5A12 in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Harris, S.F., Wu, P. 2.75 X-RAY DIFFRACTION 0.238 0.197 False True IGHV3 IGKV1 Kappa 5e-09 -11.324631107601816 SPR TBD 7mtb H L 5 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6itq B NA 0 B Hapten HCY (11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE IMMUNE SYSTEM 11/24/18 Crystal structure of cortisol complexed with its nanobody at pH 10.5 CAMELUS BACTRIANUS camelus bactrianus camelus bactrianus Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. 1.526 X-RAY DIFFRACTION 0.256 0.223 False True unknown unknown unknown None None None None None 7ew5 Z a 0 V protein NA major capsid protein l1 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 6m3c K J 0 G protein NA vitamin k-dependent protein c heavy chain BLOOD CLOTTING/IMMUNE SYSTEM 03/03/20 hAPC-h1573 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, X., Wang, D., Zhao, X., Egner, U. 3.7 X-RAY DIFFRACTION 0.302 0.278 False True IGHV3 IGKV3 Kappa None None None None None 6j11 D E 0 C protein n-terminal domain of spike glycoprotein VIRAL PROTEIN 12/27/18 MERS-CoV spike N-terminal domain and 7D10 scFv complex MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Zhou, H., Zhang, S., Zhang, S., Tang, W., Wang, X. 3.0 X-RAY DIFFRACTION 0.225 0.188 False True IGHV1 IGKV3 Kappa None None None None None 1mak NA A 14 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6v4n A B 0 I protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 1G05 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5wk3 Q P 0 A protein c-c motif chemokine 17 IMMUNE SYSTEM 07/24/17 CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.231 0.180 False True IGHV5 IGKV4 Kappa None None None None None 2ny6 D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T123C, T257S, V275C,S334A, S375W, Q428C, G431C) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.8 X-RAY DIFFRACTION 0.276 0.192 False True IGHV1 IGKV3 Kappa 1.85e-08 SPR 17301785 4i9w E D 0 A protein potassium channel subfamily k member 4 METAL TRANSPORT 12/05/12 Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Brohawn, S.G., Mackinnon, R. 2.75 X-RAY DIFFRACTION 0.236 0.201 False True IGHV1 IGKV4 Kappa None None None None None 6xsk G J 0 D | C protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral Protein 07/15/20 Cryo-EM structure of vaccine-elicited Rhesus VH6-1 antibody 789-203-3C12 in complex with stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer MACACA MULATTA; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) macaca mulatta macaca mulatta influenza a virus (a/solomonislands/3/2006(h1n1)) | influenza a virus (a/solomonislands/3/2006(h1n1)) Cerutti, G., Gorman, J., Kwong, P.D., Shapiro, L. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6sm2 NA B 0 PROTEIN FIBRIL 08/21/19 Mutant immunoglobulin light chain causing amyloidosis (Pat-1) HOMO SAPIENS homo sapiens Kazman, P., Vielberg, M.-T., Cendales, M.D.P., Hunziger, L., Weber, B., Hegenbart, U., Zacharias, M., Koehler, R., Schoenland, S., Groll, M., Buchner, J. 2.5 X-RAY DIFFRACTION 0.227 0.162 False True IGLV2 Lambda None None None None None 6hdb A NA 0 TRANSPORT PROTEIN 08/17/18 Crystal structure of the potassium channel MtTMEM175 with zinc LAMA GLAMA; ESCHERICHIA COLI (STRAIN K12); MARIVIRGA TRACTUOSA DSM 4126 lama glama, escherichia coli (strain k12) Brunner, J.D., Jakob, R.P., Schulze, T., Neldner, Y., Moroni, A., Thiel, G., Maier, T., Schenck, S. 2.9 X-RAY DIFFRACTION 0.286 0.275 False True IGHV1 None None None None None 4hdi B A 0 IMMUNE SYSTEM 10/02/12 Crystal Structure of 3E5 IgG3 FAB from mus musculus MUS MUSCULUS mus musculus mus musculus Janda, A., Eryilmaz, E., Kim, J., Cordero, R.J.B., Cowburn, D., Casadevall, A. 2.449 X-RAY DIFFRACTION 0.263 0.208 False True IGHV5 IGKV1 Kappa None None None None None 7stz H L 0 C protein NA cadherin-1 cell adhesion/immune system 11/15/21 Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.95 X-RAY DIFFRACTION 0.208 0.182 False True IGHV2 IGKV8 Kappa None None None None None 2rcj Q T 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 5b71 D C 0 F protein complement c5 beta chain IMMUNE SYSTEM 06/03/16 Crystal structure of complement C5 in complex with SKY59 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irie, M., Shimizu, Y., Sampei, Z., Fukuzawa, T. 2.11 X-RAY DIFFRACTION 0.285 0.246 False True unknown IGKV1 Kappa 1.5200000000000002e-10 -13.394361854051732 SPR TBD 4grw H NA 0 B protein interleukin-12 subunit beta IMMUNE SYSTEM 08/27/12 Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) LLAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C. 2.55 X-RAY DIFFRACTION 0.218 0.183 False True IGHV1 None None None None None 7o2z H L 0 P peptide NA p/a#1 epitope peptide IMMUNE SYSTEM 04/01/21 Crystal structure of the anti-PAS Fab 2.2 in complex with its epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Schilz, J., Schiefner, A., Skerra, A. 2.55 X-RAY DIFFRACTION 0.238 0.195 False True IGHV8 IGKV8 Kappa None None None None None 6apd H I 0 B protein fusion glycoprotein f0,envelope glycoprotein IMMUNE SYSTEM 08/17/17 Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 RESPIRATORY SYNCYTIAL VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus, humanimmunodeficiency virus 1 Wrapp, D., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.256 0.204 False True IGHV1 IGKV3 Kappa None None None None None 7lez D E 0 B protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7d00 J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with FabP5A-1B8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6p95 F G 0 b | B protein | protein NA | NA unknown | pre-glycoprotein polyprotein gp complex viral protein/immune system 06/09/19 Structure of Lassa virus glycoprotein in complex with Fab 25.6A LASSA VIRUS; HOMO SAPIENS; LASSA VIRUS (STRAIN MOUSE/SIERRA LEONE/JOSIAH/1976) homo sapiens homo sapiens lassa virus (strain mouse/sierraleone/josiah/1976) | lassa virus Saphire, E.O., Hastie, K.M. 3.5 X-RAY DIFFRACTION 0.247 0.205 False True IGHV3 IGLV2 Lambda None None None None None 1ieh A NA 0 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 7qn5 F NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4zg1 B NA 0 PROTEIN BINDING 04/22/15 Crystal structure of a nanobody raised against KDM5b LAMA GLAMA lama glama Wiuf, A., Kristensen, O., Gajhede, M. 1.85 X-RAY DIFFRACTION 0.235 0.186 False True IGHV1 None None None None None 5c8j G H 0 K protein protein mj0480 MEMBRANE PROTEIN 06/25/15 A YidC-like protein in the archaeal plasma membrane HOMO SAPIENS; METHANOCALDOCOCCUS JANNASCHII (STRAIN ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) homo sapiens homo sapiens methanocaldococcus jannaschii (strain atcc43067 / dsm 2661 / jal-1 / jcm 10045 / nbrc 100440) Borowska, M.T., Dominik, P.K., Anghel, S.A., Kossiakoff, A.A., Keenan, R.J. 3.502 X-RAY DIFFRACTION 0.302 0.253 False True IGHV3 IGKV1 Kappa None None None None None 1bzq L NA 0 A protein protein (rnase a) HYDROLASE/IMMUNE SYSTEM 11/03/98 COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Decanniere, K., Desmyter, A., Gahroudhi, M., Lauwereys, M., Muyldermans, S., Wyns, L. 2.8 X-RAY DIFFRACTION 0.282 0.222 False True IGHV1 None None None None None 6ncp A B 0 IMMUNE SYSTEM 12/11/18 Crystal structure of HIV-1 broadly neutralizing antibody ACS202 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Yuan, M., Wilson, I.A. 2.76 X-RAY DIFFRACTION 0.256 0.222 False True IGHV3 IGKV1 Kappa None None None None None 4ene E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 04/13/12 Structure of the N- and C-terminal trimmed ClC-ec1 Cl-/H+ antiporter and Fab Complex ESCHERICHIA COLI K-12; MUS MUSCULUS mus musculus mus musculus escherichia coli k-12 Hyun-Ho Lim, Shane, T., Miller, C. 2.4 X-RAY DIFFRACTION 0.278 0.239 False True IGHV4 IGKV4 Kappa None None None None None 4i3r H L 0 G protein outer domain of hiv-1 gp120 (ker2018 od4.2.2) Viral Protein/Immune System 11/26/12 Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221 HUMAN IMMUNODEFICIENCY VIRUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus Joyce, M.G., Biertumpfel, C., Nabel, G.J., Kwong, P.D. 3.0 X-RAY DIFFRACTION 0.245 0.183 False True unknown unknown unknown 1.19e-08 -10.81088821972937 SPR TBD 5tdo B A 0 IMMUNE SYSTEM 09/19/16 Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces HOMO SAPIENS homo sapiens homo sapiens Yin, Y., Carter, P.J. 1.61 X-RAY DIFFRACTION 0.267 0.237 False True IGHV3 IGKV1 Kappa None None None None None 7a6f C B 0 A protein NA multidrug resistance protein 1 TRANSPORT PROTEIN 08/25/20 Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and zosuquidar HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nosol, K., Locher, K.P. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7kmg A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/02/20 LY-CoV555 neutralizing antibody against SARS-CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hendle, J., Pustilnik, A., Sauder, J.M., Coleman, K.A., Boyles, J.S., Dickinson, C.D. 2.16 X-RAY DIFFRACTION 0.257 0.209 False True IGHV1 IGKV1 Kappa None None None None None 2x89 C NA 0 E | G protein | protein NA | NA beta-2-microglobulin | beta-2-microglobulin IMMUNE SYSTEM 03/07/10 Structure of the Beta2_microglobulin involved in amyloidogenesis HOMO SAPIENS; CAMELUS DROMEDARIUS homo sapiens homo sapiens | homo sapiens Domanska, K., Srinivasan, V., Vanderhaegen, S., Pardon, E., Marquez, J.A., Bellotti, V., Wyns, L., Steyaert, J. 2.16 X-RAY DIFFRACTION 0.26691 0.23813 False True IGHV3 4.40e-08 -10.03 SPR 21220305 2kqn NA A 4 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 4plj D C 0 B protein capsid protein VIRAL PROTEIN/IMMUME SYSTEM 05/18/14 Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing antibody 8G12 HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Li, S.W., Sivaraman, J. 2.3 X-RAY DIFFRACTION 0.242 0.187 False False IGHV1 IGKV12 Kappa None None None None None 6krz D E 0 A protein NA adiponectin receptor protein 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/22/19 Crystal structure of the human adiponectin receptor 1 D208A mutant HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Tanabe, H., Fujii, Y., Okada-Iwabu, M., Iwabu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S. 3.05 X-RAY DIFFRACTION 0.273 0.216 False True IGHV1 IGKV12 Kappa None None None None None 3upc I NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 7cvs C D 0 A protein NA h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 08/27/20 Crystal structure of the C85A/L194A mutant CLC-ec1 with Fab fragment ESCHERICHIA COLI MS 198-1; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 198-1 Park, K., Mersch, K., Robertson, J., Lim, H.-H. 3.01 X-RAY DIFFRACTION 0.255 0.201 False True IGHV4 IGKV4 Kappa None None None None None 3qxv B NA 0 B Hapten MTX METHOTREXATE IMMUNE SYSTEM 03/02/11 Structure of an Anti-Methotrexate CDR1-4 Graft VHH Antibody in Complex with Methotrexate LAMA GLAMA lama glama lama glama Fanning, S.W., Horn, J.R. 2.5 X-RAY DIFFRACTION 0.279 0.230 False True IGHV1 4e-09 -11.456840020052727 Unknown TBD 6cnk G F 0 C | B protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 03/08/18 Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Walsh Jr, R.M., Roh, S.H., Gharpure, A., Morales-Perez, C.L., Hibbs, R.E. 3.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 7v0v A NA 9 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7lzp C NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/10/21 LC/A-JPU-B9-JPU-A11-JPU-G11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.86 X-RAY DIFFRACTION 0.273 0.235 False True IGHV1 NA NA None None None None None 5mv3 L M 0 N peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 7kew I L 0 C protein NA spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-43 BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus Murin, C.D., Ward, A.B. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7r6w H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/23/21 SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2X35 Fab and S309 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Hernandez, P., Nix, J.C., Croll, T.I., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 1.83 X-RAY DIFFRACTION 0.232 0.211 False True IGHV1 IGLV1 Lambda None None None None None 4x7t H L 0 IMMUNE SYSTEM 12/09/14 Structure of Omalizumab Fab fragment, crystal form 2 HOMO SAPIENS homo sapiens homo sapiens Jensen, R.K., Andersen, G.R. 3.0 X-RAY DIFFRACTION 0.237 0.193 False True IGHV3 IGKV1 Kappa None None None None None 7pij H L 0 NA NA NA NA MEMBRANE PROTEIN 08/20/21 Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA synthetic construct synthetic construct Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7o85 NA B 0 A protein NA protective antigen pa-63 TOXIN 04/14/21 Anthrax toxin prepore in complex with the neutralizing Fab cAb29 BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus bacillus anthracis Hoelzgen, F., Zalk, R., Alcalay, R., Cohen-Schwartz, S., Garau, G., Shahar, A., Mazor, O., Frank, G.A. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 5ifj A B 0 C peptide peptide pro-leu-gln-pro-glu-gln-pro-phe-pro IMMUNE SYSTEM 02/26/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPEQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens triticum aestivum Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 2.35 X-RAY DIFFRACTION 0.241 0.205 False True IGHV3 IGLV4 Lambda None None None None None 5a1z I J 0 E protein envelope protein 05/06/15 Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C DENGUE VIRUS 2; HOMO SAPIENS homo sapiens homo sapiens dengue virus 2 Fibriansah, G., Ibarra, K.D., Ng, T.S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Jr, J.E., Lok, S.M. 6.9 ELECTRON MICROSCOPY False False IGHV1 IGLV1 Lambda None None None None None 7b18 I NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/24/20 SARS-CoV-spike bound to two neutralising nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4xpa H L 0 A protein transporter transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Aravind, P., Wang, K., Gouaux, E. 2.95 X-RAY DIFFRACTION 0.255 0.230 False True IGHV5 IGKV4 Kappa None None None None None 4hxa H L 0 IMMUNE SYSTEM 11/09/12 Crystal structure of 13D9 FAB MUS MUSCULUS mus musculus mus musculus Johal, A.R., Jarrell, H.C., Khieu, N.H., Letts, J.A., Landry, R.C., Jachymek, W., Yang, Q., Jennings, H.J., Brisson, J.R., Evans, S.V. 2.06 X-RAY DIFFRACTION 0.286 0.213 False False IGHV13 IGKV4 Kappa None None None None None 6vc9 H L 0 A protein NA 5'-nucleotidase, ecto (cd73), isoform cra_a IMMUNE SYSTEM 12/20/19 TB19 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhou, Y.F., Lord, D.M. 2.25 X-RAY DIFFRACTION 0.279 0.237 False True IGHV4 IGKV3 Kappa None None None None None 3vg0 H L 0 IMMUNE SYSTEM 01/10/12 Antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Carpenter, B., Hemsworth, G.R., Ross, R.J., Artymiuk, P.J. 2.27 X-RAY DIFFRACTION 0.260 0.190 False False IGHV2 IGKV6 Kappa None None None None None 7eyc H L 0 P peptide NA acetylated tau peptide IMMUNE SYSTEM 05/30/21 Crystal structure of Tau and acetylated tau peptide antigen MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Hong, M., Park, J. 2.49 X-RAY DIFFRACTION 0.245 0.192 False True IGHV4 IGKV1 Kappa None None None None None 6jhr E D 0 C protein vp3 VIRUS 02/18/19 The cryo-EM structure of HAV bound to a neutralizing antibody-F6 HUMAN HEPATITIS A VIRUS HU/AUSTRALIA/HM175/1976; MUS MUSCULUS mus musculus mus musculus human hepatitis a virushu/australia/hm175/1976 Cao, L., Liu, P., Yang, P., Gao, Q., Li, H., Sun, Y., Zhu, L., Lin, J., Su, D., Rao, Z., Wang, X. 3.68 ELECTRON MICROSCOPY False False IGHV5 IGKV4 Kappa None None None None None 2fx8 H L 0 P peptide fragment of hiv glycoprotein (gp41) IMMUNE SYSTEM 02/03/06 Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Brunel, F.M., Ferguson, S., Burton, D.R., Dawson, P.E., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.283 0.235 False True IGHV1 IGKV3 Kappa 3.02e-07 -8.89 SPR 17125793 7wph H L 0 B protein NA spike protein s1 PROTEIN BINDING 01/23/22 SARS-CoV2 RBD bound to Fab06 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Lin, J.Q., El Sahili, A., Lescar, J. 2.89 X-RAY DIFFRACTION 0.269 0.229 False True IGHV4 IGLV2 Lambda None None None None None 3ogc A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 08/16/10 KcsA E71A variant in presence of Na+ MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans McCoy, J.G., Nimigean, C.M. 3.8 X-RAY DIFFRACTION 0.283 0.247 False True IGHV1 IGKV5 Kappa None None None None None 1maj NA A 0 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4i18 H L 0 C protein prolactin receptor CYTOKINE, SIGNALING PROTEIN 11/20/12 Crystal structure of human prolactin receptor complexed with Fab fragment MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Duguid, E.M., Mukherjee, S., Kouadio, J.L. 3.238 X-RAY DIFFRACTION 0.246 0.191 False True IGHV3 IGKV1 Kappa 5.6e-09 -11.25748571108156 SPR TBD 4oii I M 0 B protein non-structural protein ns1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/14 West Nile Virus NS1 in complex with neutralizing 22NS1 antibody Fab WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Edeling, M.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.0 X-RAY DIFFRACTION 0.265 0.214 False True IGHV1 IGKV12 Kappa None None None None None 7tty H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/02/22 Crystal structure of potent neutralizing antibody 10-40 in complex with bat WIV1 receptor-binding domain BAT SARS-LIKE CORONAVIRUS WIV1; HOMO SAPIENS homo sapiens homo sapiens bat sars-like coronavirus wiv1 Reddem, E.R., Shapiro, L. 3.11 X-RAY DIFFRACTION 0.329 0.235 False True IGHV4 IGLV6 Lambda None None None None None 6rlo G H 0 L protein NA cd9 antigen IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop HOMO SAPIENS homo sapiens homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.2 X-RAY DIFFRACTION 0.287 0.254 False True IGHV3 IGKV4 Kappa None None None None None 6xpr B C 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/08/20 Human antibody D2 H1-1/H3-1 H3 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2) INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C., Lee, J. 4.092 X-RAY DIFFRACTION 0.298 0.252 False True IGHV3 IGKV1 Kappa None None None None None 6h06 A B 0 K peptide microtubule-associated protein tau IMMUNE SYSTEM 07/06/18 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Juraszek, J., Steinbacher, S. 2.63 X-RAY DIFFRACTION 0.270 0.216 False True IGHV1 IGKV2 Kappa 5.6e-06 -7.164753442850797 Unknown TBD 7o85 NA K 0 J | L protein | protein NA | NA protective antigen pa-63 | fab TOXIN 04/14/21 Anthrax toxin prepore in complex with the neutralizing Fab cAb29 BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus bacillus anthracis | mus musculus Hoelzgen, F., Zalk, R., Alcalay, R., Cohen-Schwartz, S., Garau, G., Shahar, A., Mazor, O., Frank, G.A. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 4xwo W X 0 T protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 3d85 B A 0 C protein interleukin-23 subunit p19 IMMUNE SYSTEM/CYTOKINE 05/22/08 Crystal structure of IL-23 in complex with neutralizing FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V. 1.9 X-RAY DIFFRACTION 0.214 0.171 False False IGHV1 IGKV5 Kappa None None None None None 1t3f B A 0 IMMUNE SYSTEM 04/26/04 THREE DIMENSIONAL STRUCTURE OF A HUMANIZED ANTI-IFN-GAMMA FAB (HuZAF) IN P21 21 21 SPACE GROUP HOMO SAPIENS homo sapiens homo sapiens Bourne, P.C., Terzyan, S.S., Cloud, G., Landolfi, N.F., Vasquez, M., Edmundson, A.B. 2.0 X-RAY DIFFRACTION 0.222 0.172 False True IGHV1 IGKV1 Kappa None None None None None 3cvh H L 0 A | C protein | peptide NA | NA h-2 class i histocompatibility antigen, k-b alpha chain | ovalbumin IMMUNE SYSTEM 04/18/08 How TCR-like antibody recognizes MHC-bound peptide MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus mus musculus | gallus gallus Mareeva, T., Martinez-Hackert, E., Sykulev, Y. 2.9 X-RAY DIFFRACTION 0.296 0.219 False False IGHV1 IGKV13 Kappa None None None None None 7m8l O R 0 F protein NA virion spike glycoprotein 2 VIRAL PROTEIN/IMMUNE SYSTEM 03/30/21 EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7wk8 C D 0 A | B protein | peptide NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 01/08/22 SARS-CoV-2 Omicron spike protein SD1 in complex with S3H3 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 3.61 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6bah B A 0 C | E protein | protein NA | NA immunoglobulin g binding protein a | protein l IMMUNE SYSTEM 10/12/17 Trastuzumab Fab v3 with 5-diphenyl meditope variant MUS MUSCULUS; HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens staphylococcus aureus | finegoldia magna Bzymek, K.P., King, J.D., Williams, J.C. 1.9 X-RAY DIFFRACTION 0.194 0.164 False True IGHV3 IGKV1 Kappa None None None None None 4z8f H L 0 E | A nucleic-acid | nucleic-acid NA | NA 5'-d(p*tp*tp*tp*tp*t)-3' | 5'-d(p*tp*tp*tp*tp*t)-3' IMMUNE SYSTEM/DNA 04/08/15 Fab structure of antibody S1-15 in complex with ssDNA DNA, 5'-p5(dT)p-3' MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | Haji-Ghassemi, O., Evans, S.V. 1.75 X-RAY DIFFRACTION 0.240 0.208 False False IGHV10 IGKV10 Kappa None None None None None 5x4g A B 0 IMMUNE SYSTEM 02/13/17 Crystal structure of Fab fragment of anti-CD147 monoclonal antibody 6H8 MUS MUSCULUS mus musculus mus musculus Lin, P., Zhang, M.-Y., Chen, X., Ye, S., Yu, X.-L., Zhang, R.-G., Zhu, P., Chen, Z.-N. 1.45 X-RAY DIFFRACTION 0.226 0.206 False True IGHV6 IGKV6 Kappa None None None None None 5c3l D NA 0 C | A | B protein | protein | protein NA | NA | NA nucleoporin nup62 | nup54 | nucleoporin nup58 TRANSPORT PROTEIN 06/17/15 Structure of the metazoan Nup62.Nup58.Nup54 nucleoporin complex. XENOPUS LAEVIS; CAMELUS DROMEDARIUS camelus dromedarius xenopus laevis | xenopus laevis | xenopus laevis Chug, H., Trakhanov, S., Hulsmann, B.B., Pleiner, T., Gorlich, D. 2.9 X-RAY DIFFRACTION 0.301 0.265 False True IGHV3 None None None None None 6lfx A a 0 a Hapten OM4 1,2-bis(chloranyl)-4-(3-chloranyl-4-methoxy-phenyl)benzene IMMUNE SYSTEM 12/03/19 Crystal structure of PCB4scFv(hN56D) in complex with PCB#77 MUS MUSCULUS mus musculus Nakamura, T., Yamagata, Y., Morioka, H. 1.43 X-RAY DIFFRACTION 0.166 0.136 True True unknown unknown unknown None None None None None 5jof A B 0 IMMUNE SYSTEM 05/02/16 Crystal structure of VRC03 gHVgLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 3.208 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 IGKV3 Kappa None None None None None 6mej H L 0 C protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS; HEPACIVIRUS C homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 2.8 X-RAY DIFFRACTION 0.271 0.198 False True IGHV1 IGKV1 Kappa None None None None None 5wb2 A NA 0 MEMBRANE PROTEIN 06/27/17 US28 bound to engineered chemokine CX3CL1.35 and nanobodies HUMAN CYTOMEGALOVIRUS; LAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT human cytomegalovirus, lama glama Jude, K.M., Burg, J.S., Tsutsumi, N., Miles, T.F., Garcia, K.C. 3.5 X-RAY DIFFRACTION 0.296 0.252 False True IGHV1 None None None None None 4xce C D 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylcholine (06:0 PC); C2 space group HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.93 X-RAY DIFFRACTION 0.247 0.192 False True IGHV1 IGKV3 Kappa None None None None None 6hjx G NA 0 B protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.5 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 None None None None None 6ikm O o 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 7b27 D NA 0 a protein NA unknown VIRAL PROTEIN 11/26/20 RBD domain SARS-CoV2 in complex with neutralizing nanobody NM1230 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS Ostertag, E., Zocher, G., Stehle, T. 2.902 X-RAY DIFFRACTION 0.305 0.266 False False unknown unknown unknown None None None None None 6my5 A B 0 IMMUNE SYSTEM 11/01/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98F,HC-G99M,LC-S30bR] HOMO SAPIENS homo sapiens homo sapiens Shi, R. 1.73 X-RAY DIFFRACTION 0.229 0.186 False True IGHV3 IGKV1 Kappa None None None None None 5dhy H L 0 M protein protein rev IMMUNE SYSTEM 08/31/15 HIV-1 Rev NTD dimers with variable crossing angles HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C. 3.1 X-RAY DIFFRACTION 0.300 0.291 False True IGHV1 IGKV1 Kappa None None None None None 1j05 B A 0 Immune system 11/01/02 The crystal structure of anti-carcinoembryonic antigen monoclonal antibody T84.66 Fv fragment MUS MUSCULUS mus musculus mus musculus Kondo, H., Nishimura, Y., Shiroishi, M., Asano, R., Noro, N., Tsumoto, K., Kumagai, I. 1.5 X-RAY DIFFRACTION unknown unknown False True IGHV14 IGKV3 Kappa None None None None None 5j3h C D 0 E protein insulin receptor HORMONE RECEPTOR/IMMUNE SYSTEM 03/30/16 Human insulin receptor domains L1-CR in complex with peptide S519C16 and 83-7 Fv HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M., Menting, J., Lawrence, C. 3.27 X-RAY DIFFRACTION 0.248 0.226 False True IGHV2 IGKV8 Kappa 2.5e-09 -11.735309499921595 ITC TBD 2v7n F E 0 IMMUNE SYSTEM 07/31/07 Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4 SYNTHETIC CONSTRUCT synthetic construct synthetic construct Frey, D., Huber, T., Plueckthun, A., Gruetter, M.G. 1.92 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 6udk O P 0 R protein rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 3chn C O 0 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7whk F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5etu D C 0 IMMUNE SYSTEM 11/18/15 Cetuximab Fab in complex with L5E meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.53 X-RAY DIFFRACTION 0.232 0.180 False True IGHV2 IGKV5 Kappa 0.00013 -5.301529812728825 Unknown TBD 2vxt H L 0 I protein interleukin-18 CYTOKINE 07/10/08 Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Argiriadi, M.A., Xiang, T., Wu, C., Ghayur, T., Borhani, D.W. 1.49 X-RAY DIFFRACTION 0.196 0.162 False True IGHV1 IGKV9 Kappa 5.33e-10 -12.64 SPR 19553661 6q0e H L 0 A protein hemagglutinin IMMUNE SYSTEM 08/01/19 Inferred precursor (UCA) of the human antibody lineage 652 in complex with influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) McCarthy, K.R., Harrison, S.C. 2.15 X-RAY DIFFRACTION 0.249 0.230 False True IGHV4 IGLV3 Lambda None None None None None 6mb3 G Q 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6sne D C 0 J peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.9 X-RAY DIFFRACTION 0.261 0.218 False True IGHV4 IGKV1 Kappa None None None None None 4mxw W V 0 X protein lymphotoxin-alpha CYTOKINE/IMMUNE SYSTEM 09/26/13 Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sudhamsu, J., Yin, J.P., Hymowitz, S.G. 3.6 X-RAY DIFFRACTION 0.296 0.231 False True IGHV3 IGKV1 Kappa None None None None None 5m95 B NA 0 A protein divalent metal cation transporter mnth TRANSPORT PROTEIN 10/31/16 STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE LAMA GLAMA; STAPHYLOCOCCUS CAPITIS lama glama staphylococcus capitis Ehrnstorfer, I.A., Geertsma, E.R., Pardon, E., Steyaert, J., Dutzler, R. 3.4 X-RAY DIFFRACTION 0.292 0.252 False True IGHV1 None None None None None 5ir1 B A 0 IMMUNE SYSTEM 03/11/16 Cetuximab Fab in complex with 3-bromophenylalanine meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.482 X-RAY DIFFRACTION 0.215 0.163 False True IGHV2 IGKV5 Kappa None None None None None 7me7 A NA 0 R protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/06/21 CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb17 and Nb105 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D.J. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2iqa H L 0 IMMUNE SYSTEM 10/13/06 PFA2 FAB fragment, monoclinic apo form MUS MUSCULUS mus musculus mus musculus Gardberg, A.S., Dealwis, C. 2.0 X-RAY DIFFRACTION 0.279 0.230 False False IGHV8 IGKV1 Kappa None None None None None 6b3j N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/22/17 3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Liang, Y.L., Khoshouei, M., Glukhova, A., Furness, S.G.B., Koole, C., Zhao, P., Clydesdale, L., Thal, D.M., Radjainia, M., Danev, R., Baumeister, W., Wang, M.W., Miller, L.J., Christopoulos, A., Sexton, P.M., Wootten, D. 3.3 ELECTRON MICROSCOPY False True IGHV3 None None None None None 1rul H L 0 immune system 12/11/03 Crystal Structure (D) of u.v.-irradiated cationic cyclization antibody 4C6 Fab at pH 5.6 with a data set collected at SSRL beamline 11-1. MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 1.88 X-RAY DIFFRACTION unknown unknown False False IGHV3 IGKV1 Kappa None None None None None 5c9k NA H 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 6ch9 D E 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated B41 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4.85 X-RAY DIFFRACTION 0.292 0.285 False True unknown unknown unknown None None None None None 5tru H L 0 C protein cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 10/27/16 Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ramagopal, U.A., Liu, W., Garrett-Thomson, S.C., Yan, Q., Srinivasan, M., Wong, S.C., Bell, A., Mankikar, S., Rangan, V.S., Deshpande, S., Bonanno, J.B., Korman, A.J., Almo, S.C. 3.0 X-RAY DIFFRACTION 0.268 0.204 False True IGHV3 IGKV3 Kappa 1.06e-08 -10.87942933816716 Unknown TBD 5kan H L 0 B | C protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.g.07 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.785 X-RAY DIFFRACTION 0.243 0.218 False True IGHV1 IGKV1 Kappa None None None None None 5zmj H L 0 IMMUNE SYSTEM 04/04/18 Crystal structure of the Fab region of a neutralizing fully human antibody against GM-CSF HOMO SAPIENS homo sapiens homo sapiens Angkawidjaja, C., Torashima, T. 1.81 X-RAY DIFFRACTION 0.191 0.161 False True IGHV7 IGLV1 Lambda None None None None None 3cfb H L 0 L Hapten SPB 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID IMMUNE SYSTEM 03/03/08 High-resolution structure of blue fluorescent antibody EP2-19G2 in complex with stilbene hapten at 100K MUS MUSCULUS mus musculus mus musculus mus musculus Debler, E.W., Wilson, I.A. 1.6 X-RAY DIFFRACTION 0.218 0.186 False False IGHV5 IGKV2 Kappa None None None None None 4nkm G H 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.71 X-RAY DIFFRACTION 0.282 0.264 False True IGHV1 IGKV1 Kappa None None None None None 7joz N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/07/20 Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist HOMO SAPIENS; LAMA GLAMA; ENTEROBACTERIA PHAGE T4 lama glama homo sapiens | homo sapiens Sun, B., Feng, D., Chu, M.L., Fish, I., Kelm, S., Lebon, F., Lovera, S., Valade, A., Wood, M., Ceska, T., Kobilka, T.S., Sands, Z., Kobilka, B.K. 3.8 X-RAY DIFFRACTION 0.297 0.254 False True IGHV3 NA NA None None None None None 6h1f A NA 0 B protein gelsolin STRUCTURAL PROTEIN 07/11/18 Structure of the nanobody-stabilized gelsolin D187N variant (second domain) LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Hassan, A., Milani, M., Mastrangelo, E., de Rosa, M. 1.9 X-RAY DIFFRACTION 0.233 0.199 False True IGHV1 None None None None None 6ezw B NA 0 IMMUNE SYSTEM 11/16/17 Crystal structure of a llama VHH antibody BCD090-M2 against human ErbB3 in space group C2 LAMA GLAMA lama glama Eliseev, I.E., Yudenko, A.N., Vysochinskaya, V.V., Svirina, A.A., Evstratyeva, A.V., Drozhzhachih, M.S., Krendeleva, E.A., Vladimirova, A.K., Nemankin, T.A., Ekimova, V.M., Ulitin, A.B., Lomovskaya, M.I., Yakovlev, P.A., Moiseenko, F.V., Chakchir, O.B. 1.59843 X-RAY DIFFRACTION 0.213 0.182 False True IGHV1 None None None None None 7ngh D NA 0 B protein NA proton/glutamate symporter, sdf family TRANSPORT PROTEIN 02/09/21 Structure of glutamate transporter homologue in complex with Sybody THERMOCOCCUS KODAKARENSIS KOD1; SYNTHETIC CONSTRUCT synthetic construct thermococcus kodakarensis kod1 Arkhipova, V., Slotboom, D.J., Guskov, A. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7v0v A NA 6 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 4n9g M N 0 Z peptide epitope scaffold rsv_1isea_ffl_001_c IMMUNE SYSTEM 10/21/13 Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9 MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta synthetic construct Carrico, C.T.D., Strong, R.K. 2.5 X-RAY DIFFRACTION 0.295 0.263 False True IGHV4 IGKV1 Kappa 3.26e-10 -12.942286816628542 Unknown TBD 4hg4 L M 0 B protein hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 6dba B NA 0 IMMUNE SYSTEM 05/02/18 Crystal Structure of VHH R303 CAMELUS DROMEDARIUS camelus dromedarius Brooks, C.L., Toride King, M., Huh, I. 1.3 X-RAY DIFFRACTION 0.182 0.161 False True IGHV1 None None None None None 4xgz U V 0 u peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 5vn8 I K 0 E protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/28/17 Cryo-EM model of B41 SOSIP.664 in complex with fragment antigen binding variable domain of b12 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Pallesen, J., Ward, A.B., Cottrell, C.A. 3.6 ELECTRON MICROSCOPY / HOMOLOGY MODEL False True IGHV1 IGKV3 Kappa None None None None None 2kqn NA A 9 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1kcv H L 0 IMMUNE SYSTEM 11/11/01 Crystal structure of antibody pc282 MUS MUSCULUS mus musculus mus musculus Nair, D.T., Singh, K., Siddiqui, Z., Nayak, B.P., Rao, K.V., Salunke, D.M. 1.8 X-RAY DIFFRACTION 0.233 0.203 False False IGHV3 IGKV6 Kappa None None None None None 4k3g NA A 0 IMMUNE SYSTEM 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activating protein HOMO SAPIENS homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 1.93 X-RAY DIFFRACTION 0.231 0.193 False True IGLV7 Lambda None None None None None 2omb NA D 0 Immune system 01/21/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(1)21 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.9 X-RAY DIFFRACTION 0.284 0.235 False False IGLV2 Lambda None None None None None 7ew5 W X 0 S protein NA major capsid protein l1 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 1y0l F E 0 F Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/15/04 Catalytic elimination antibody 34E4 in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.239 0.204 False True IGHV4 IGLV1 Lambda 1e-09 -12.27819680469229 Unknown TBD 3juy F f 0 IMMUNE SYSTEM 09/15/09 Crystal Structure of a 3B3 Variant, a Broadly Neutralizing HIV-1 scFv Antibody HOMO SAPIENS homo sapiens Clark, K.R., Walsh, S.T. 2.5 X-RAY DIFFRACTION 0.260 0.195 True True unknown unknown unknown None None None None None 6b0h B A 0 J protein pfs25 IMMUNE SYSTEM 09/14/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1262 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum McLeod, B., Scally, S.W., Bosch, A., King, C.R., Julien, J.P. 2.7 X-RAY DIFFRACTION 0.238 0.186 False True IGHV4 IGKV1 Kappa None None None None None 3lrs A B 0 B carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 02/11/10 Structure of PG16, an antibody with broad and potent neutralization of HIV-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pancera, M., Kwong, P.D. 2.37 X-RAY DIFFRACTION 0.260 0.211 False True IGHV3 IGLV2 Lambda None None None None None 6e8v Y Z 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False True IGHV1 IGLV1 Lambda None None None None None 3fku S s 0 J | I protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/17/08 Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens influenza a virus | influenza a virus Hwang, W.C., Santelli, E., Stec, B., Wei, G., Cadwell, G., Bankston, L.A., Sui, J., Perez, S., Aird, D., Chen, L.M., Ali, M., Murakami, A., Yammanuru, A., Han, T., Cox, N., Donis, R.O., Liddington, R.C., Marasco, W.A. 3.2 X-RAY DIFFRACTION 0.286 0.232 True True unknown unknown unknown 1.30E-10 -13.48 SPR 25 19234466 5yfi H L 0 IMMUNE SYSTEM 09/21/17 Crystal structure of the clinically important GPCR in complex with functional antibody MUS MUSCULUS mus musculus mus musculus Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T. 1.848 X-RAY DIFFRACTION 0.232 0.194 False False IGHV1 IGKV14 Kappa None None None None None 6dbd A NA 0 IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R326 LAMA GLAMA lama glama Brooks, C.L., Toride King, M., Huh, I. 1.755 X-RAY DIFFRACTION 0.182 0.160 False True unknown unknown unknown None None None None None 4hkb A B 0 IMMUNE SYSTEM 10/15/12 CH67 Fab (unbound) from the CH65-67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 3.6 X-RAY DIFFRACTION 0.306 0.258 False True IGHV1 IGLV3 Lambda None None None None None 3gbm H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin viral protein / immune system 02/20/09 Crystal Structure of Fab CR6261 in Complex with a H5N1 influenza virus hemagglutinin. INFLUENZA A VIRUS (A/VIET NAM/1203/2004(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) | influenza a virus (a/viet nam/1203/2004(h5n1)) Ekiert, D.C., Elsliger, M.A., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.261 0.203 False True IGHV1 IGLV1 Lambda None None None None None 7r4i D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/08/22 The SARS-CoV-2 spike in complex with the 2.15 neutralizing nanobody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Melero, R., Arranz, R., Fernandez, L.A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5i74 B C 0 A protein sodium-dependent serotonin transporter MEMBRANE PROTEIN 02/16/16 X-ray structure of the ts3 human serotonin transporter complexed with Br-citalopram at the central site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Green, E.M., Gouaux, E. 3.395 X-RAY DIFFRACTION 0.296 0.249 False True IGHV1 IGKV6 Kappa None None None None None 7q9i H L 0 A protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-43 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6pxg A B 0 IMMUNE SYSTEM 07/26/19 Crystal Structure of MERS-CoV neutralizing antibody G2 Fab MUS MUSCULUS mus musculus mus musculus Wang, N., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.225 0.181 False True IGHV1 IGKV3 Kappa None None None None None 2kqm NA B 0 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6nov A B 0 IMMUNE SYSTEM 01/16/19 A Fab derived from ixekizumab HOMO SAPIENS homo sapiens homo sapiens Durbin, J.D., Clawson, D.K., Lu, F., Tian, Y., Lu, J., Schmitt, M., Atwell, S. 2.14 X-RAY DIFFRACTION 0.278 0.238 False True IGHV1 IGKV2 Kappa None None None None None 7rly E F 0 R peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide DRAAGQPAGDRADGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.67 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 IGKV1 Kappa None None None None None 6ugt H L 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of PF06438179/GP1111 an infliximab biosimilar in a I-centered orthorhombic crystal form, Lot A HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H.D. 2.15 X-RAY DIFFRACTION 0.228 0.185 False True IGHV6 IGKV5 Kappa None None None None None 1u0q A NA 0 IMMUNE SYSTEM 07/14/04 Structure of a Llama VHH domain raised against a carbazole molecule LAMA GLAMA lama glama Cambillau, C., Spinelli, S., Desmyter, A., Verrips, T. 1.6 X-RAY DIFFRACTION 0.250 0.221 False True IGHV1 None None None None None 5hdo B NA 0 IMMUNE SYSTEM 01/05/16 Crystal structure of a nanobody raised against urokinase-type plasminogen activator CAMELUS DROMEDARIUS camelus dromedarius Kromann-Hansen, T. 2.16 X-RAY DIFFRACTION 0.218 0.177 False True IGHV1 None None None None None 4nj9 H L 0 H Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 11/08/13 Crystal structure of Fab 8B10 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Romesberg, F.E., Zimmermann, J., Wilson, I.A. 1.95 X-RAY DIFFRACTION 0.264 0.214 False False IGHV1 IGKV3 Kappa 1.08e-07 -9.504110465002816 Unknown TBD 7kf9 H K 0 B protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-296 and EBOV-515 HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 7p78 Y NA 0 E protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 1up/1up-out/1down conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4bz1 H L 0 A protein envelope protein IMMUNE SYSTEM/VIRAL PROTEIN 07/23/13 Structure of dengue virus EDIII in complex with Fab 3e31 DENGUE VIRUS 4; MUS MUSCULUS mus musculus mus musculus dengue virus 4 Li, J., Watterson, D., Chang, C.W., Li, X.Q., Ericsson, D.J., Qiu, L.W., Cai, J.P., Chen, J., Fry, S.R., Cooper, M.A., Che, X.Y., Young, P.R., Kobe, B. 2.15 X-RAY DIFFRACTION 0.2546 0.2234 False False IGHV1 IGKV8 Kappa None None None None None 3hc4 H L 0 IMMUNE SYSTEM 05/05/09 BHA10 IgG1 Fab quadruple mutant variant - antibody directed at human LTBR HOMO SAPIENS homo sapiens homo sapiens Arndt, J.W., Jordan, J.L., Lugovskoy, A., Wang, D. 1.62 X-RAY DIFFRACTION 0.180 0.161 False True IGHV1 IGKV1 Kappa None None None None None 7e8f H L 0 A protein NA spike protein s1 VIRAL PROTEIN 03/01/21 SARS-CoV-2 NTD in complex with N9 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7jwq C D 0 P peptide NA il-1beta peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-1beta peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 2.001 X-RAY DIFFRACTION 0.232 0.204 False True IGHV1 IGKV1 Kappa None None None None None 6gju B NA 0 A protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/17/18 human NBD1 of CFTR in complex with nanobodies T2a and T4 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.6 X-RAY DIFFRACTION 0.244 0.220 False True IGHV1 None None None None None 7klh H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 10/30/20 SARS-CoV-2 RBD in complex with Fab 15033-7 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 3.0 X-RAY DIFFRACTION 0.284 0.256 False True IGHV3 IGKV1 Kappa None None None None None 6apd K M 0 B protein fusion glycoprotein f0,envelope glycoprotein IMMUNE SYSTEM 08/17/17 Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 RESPIRATORY SYNCYTIAL VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus, humanimmunodeficiency virus 1 Wrapp, D., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.256 0.204 False True IGHV3 IGLV1 Lambda None None None None None 1jp5 b B 0 D peptide epitope peptide corresponding to n-terminus ofhiv-1 protease IMMUNE SYSTEM 08/01/01 Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-1 protease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus Rezacova, P., Lescar, J., Brynda, J., Fabry, M., Horejsi, M., Sedlacek, J., Bentley, G.A. 2.7 X-RAY DIFFRACTION 0.287 0.229 True True unknown unknown unknown None None None None None 5w3l E G 0 B | A | C protein | protein | protein NA | NA | NA viral protein 3 | viral protein 1 | viral protein 2 VIRUS/IMMUNE SYSTEM 06/08/17 CryoEM structure of rhinovirus B14 in complex with C5 Fab (4 degrees Celsius, molar ratio 1:3, full particle) HUMAN RHINOVIRUS 14; MUS MUSCULUS mus musculus mus musculus human rhinovirus 14 | human rhinovirus 14 | human rhinovirus 14 Liu, Y., Dong, Y., Rossmann, M.G. 2.71 ELECTRON MICROSCOPY False False IGHV2 IGKV12 Kappa None None None None None 6nmt B A 0 C protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Non-Blocking Fab 3 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 1.83 X-RAY DIFFRACTION 0.204 0.178 False True unknown unknown unknown None None None None None 4c83 A B 0 A carbohydrate NDG polysaccharide IMMUNE SYSTEM 09/29/13 Crystal Structure of the IgG2a LPT3 in complex with an 8-sugar inner core analogue of Neisseria meningitidis MUS MUSCULUS mus musculus mus musculus mus musculus Parker, M.J., Gomery, K., Richard, G., Mackenzie, C.R., Cox, A.D., Richards, J.C., Evans, S.V. 2.69 X-RAY DIFFRACTION 0.29255 0.22484 False False IGHV5 IGKV4 Kappa None None None None None 4xrc B A 0 D protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 01/20/15 Antibody hemagglutinin Complexes HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/THAILAND/TAK-01/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/chicken/thailand/tak-01/2004(h5n1)) Spiller, B.W., Winarski, K.L. 2.74 X-RAY DIFFRACTION 0.248 0.192 False True IGHV4 IGLV3 Lambda None None None None None 6w2c B C 0 A protein sodium-dependent serotonin transporter TRANSPORT PROTEIN 03/05/20 Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Navratna, V., Yang, D. 6.3 X-RAY DIFFRACTION 0.370 0.306 False True IGHV1 IGKV6 Kappa None None None None None 3qxv D NA 0 D Hapten MTX METHOTREXATE IMMUNE SYSTEM 03/02/11 Structure of an Anti-Methotrexate CDR1-4 Graft VHH Antibody in Complex with Methotrexate LAMA GLAMA lama glama lama glama Fanning, S.W., Horn, J.R. 2.5 X-RAY DIFFRACTION 0.279 0.230 False True IGHV1 4e-09 -11.456840020052727 Unknown TBD 1mam H L 0 IMMUNOGLOBULIN 01/14/92 CRYSTAL STRUCTURE TO 2.45 A RESOLUTION OF A MONOCLONAL FAB SPECIFIC FOR THE BRUCELLA A CELL WALL POLYSACCHARIDE ANTIGEN MUS MUSCULUS mus musculus mus musculus Rose, D.R. 2.45 X-RAY DIFFRACTION unknown unknown False True IGHV7 IGKV10 Kappa None None None None None 6svl K M 0 N protein myeloid-derived growth factor CYTOKINE 09/18/19 human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ebenhoch, R., Nar, H. 1.58 X-RAY DIFFRACTION 0.206 0.181 False True IGHV14 IGKV12 Kappa None None None None None 5f6h M N 0 IMMUNE SYSTEM 12/06/15 Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.66 X-RAY DIFFRACTION 0.262 0.230 False True IGHV3 IGLV2 Lambda None None None None None 7kmk H L 0 A protein NA spike glycoprotein Viral protein/Immune System 11/03/20 cryo-EM structure of SARS-CoV-2 spike in complex with Fab 15033-7, two RBDs bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6rcq A B 0 IMMUNE SYSTEM 04/11/19 PfRH5-binding monoclonal antibody R5.011 HOMO SAPIENS homo sapiens homo sapiens Alanine, D.W.G., Draper, S.J., Higgins, M.K. 2.28 X-RAY DIFFRACTION 0.227 0.185 False True IGHV7 IGLV3 Lambda None None None None None 1hi6 B A 0 C peptide peptide 5 IMMUNE SYSTEM/PEPTIDE 01/02/01 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Hahn, M., Wessner, H., Schneider-Mergener, J., Hohne, W. 2.55 X-RAY DIFFRACTION 0.329 0.284 False False IGHV1 IGKV14 Kappa None None None None None 5npi B b 0 E peptide epitope peptide VIRAL PROTEIN 04/16/17 Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus hepatitis c virus Vasiliauskaite, I., Rey, F.A., Krey, T. 2.0 X-RAY DIFFRACTION 0.217 0.197 True True unknown unknown unknown None None None None None 3jcb C B 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/25/15 Structure of Simian Immunodeficiency Virus Envelope Spikes bound with CD4 and Monoclonal Antibody 36D5 HOMO SAPIENS; SIMIAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens simian immunodeficiency virus Hu, G., Liu, J., Roux, K., Taylor, K.A. NOT ELECTRON MICROSCOPY False False IGHV4 IGLV3 Lambda None None None None None 6phc A B 0 I protein 25 kda ookinete surface antigen IMMUNE SYSTEM 06/25/19 Pfs25 in complex with the human transmission blocking antibody 2544 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum McLeod, B.R., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.238 0.200 False True IGHV3 IGKV2 Kappa None None None None None 2x1p A NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama VandenAbbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., VanLoo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.1 X-RAY DIFFRACTION 0.220 0.203 False True IGHV1 None None None None None 3uyr H L 0 P peptide h-2 class i histocompatibility antigen, l-d alpha chain IMMUNE SYSTEM 12/06/11 Structure of a monoclonal antibody complexed with its MHC-I antigen MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K. 1.7 X-RAY DIFFRACTION 0.226 0.192 False False IGHV5 IGKV1 Kappa 1.27e-07 -9.408095013098825 Unknown TBD 7cz0 G NA 0 C protein NA thermostable green fluorescent protein (tgp) FLUORESCENT PROTEIN 09/06/20 Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb92) GALAXEA FASCICULARIS; SYNTHETIC CONSTRUCT synthetic construct galaxea fascicularis Cai, H., Yao, H., Li, T., Hutter, C., Tang, Y., Li, Y., Seeger, M., Li, D. 2.77 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 NA NA None None None None None 4r7n C D 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 5tl5 H L 0 A protein cd27 antigen IMMUNE SYSTEM 10/10/16 COMPLEX BETWEEN HUMAN CD27 AND ANTIBODY M2177 MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 1.8 X-RAY DIFFRACTION 0.232 0.197 False True IGHV1 IGKV3 Kappa None None None None None 4lgr B NA 0 A protein NA ricin HYDROLASE/IMMUNE SYSTEM 06/28/13 Ricin A chain bound to camelid nanobody (VHH3) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Cheung, J., Franklin, M., Burshteyn, F., Cassidy, M., Gary, E., Mantis, N. 1.65 X-RAY DIFFRACTION 0.204 0.180 False True IGHV1 NA NA None None None None None 7dss A NA 0 1 | 3 protein | protein NA | NA vp1 of o type fmdv capsid | vp3 of o-type fmdv capsid VIRUS 01/02/21 Complex of FMDV and M8 Nab VICUGNA PACOS; FOOT-AND-MOUTH DISEASE VIRUS vicugna pacos foot-and-mouth disease virus | foot-and-mouth disease virus Dong, H., Liu, P. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5i71 B C 0 A protein sodium-dependent serotonin transporter MEMBRANE PROTEIN 02/16/16 X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Coleman, J.A., Green, E.M., Gouaux, E. 3.15 X-RAY DIFFRACTION 0.276 0.240 False True IGHV1 IGKV6 Kappa None None None None None 6z1v B NA 0 A protein NA cd9 antigen CELL ADHESION 05/14/20 Structure of the EC2 domain of CD9 in complex with nanobody 4E8 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Oosterheert, W., Pearce, N.M., Gros, P. 1.33 X-RAY DIFFRACTION 0.190 0.151 False True IGHV1 NA NA None None None None None 4o51 F E 0 P peptide ides hinge peptide IMMUNE SYSTEM 12/19/13 Crystal structure of the QAA variant of anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide ORYCTOLAGUS CUNICULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens homo sapiens Malia, T.J., Luo, J., Teplyakov, A., Gilliland, G.L. 2.204 X-RAY DIFFRACTION 0.213 0.182 False True IGHV1 IGKV1 Kappa None None None None None 4irz H L 0 A protein integrin alpha4 subunit IMMUNE SYSTEM 01/15/13 Crystal structure of A4b7 headpiece complexed with Fab Natalizumab ORYCTOLAGUS CUNICULUS; HOMO SAPIENS homo sapiens homo sapiens oryctolagus cuniculus Yu, Y., Schurpf, T., Springer, T.A. 2.84 X-RAY DIFFRACTION 0.287 0.237 False True IGHV1 IGKV1 Kappa None None None None None 7qjj G NA 0 E protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of a Mn2+ soak of EleNRMT in complex with two Nanobodies at 4.6A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.6 X-RAY DIFFRACTION 0.327 0.284 False True IGHV1 NA NA None None None None None 6gju C NA 0 A protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/17/18 human NBD1 of CFTR in complex with nanobodies T2a and T4 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.6 X-RAY DIFFRACTION 0.244 0.220 False True IGHV1 None None None None None 7jmw H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/03/20 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with cross-neutralizing antibody COVA1-16 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.89 X-RAY DIFFRACTION 0.291 0.238 False True IGHV1 IGKV1 Kappa None None None None None 6ugu A B 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a C-centered orthorhombic crystal form, Lot C HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H.D. 2.2 X-RAY DIFFRACTION 0.219 0.170 False True IGHV6 IGKV5 Kappa None None None None None 6k2i A NA 8 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 3b9v D NA 0 IMMUNE SYSTEM 11/06/07 Crystal Structure of an Autonomous VH Domain HOMO SAPIENS homo sapiens Appleton, B.A., Barthelemy, P.A., Wiesmann, C. 1.8 X-RAY DIFFRACTION 0.200 0.155 False True IGHV3 None None None None None 7oay F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 2.34 X-RAY DIFFRACTION 0.228 0.192 False False IGHV1 NA NA None None None None None 7zml K NA 0 C protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G1-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.79 X-RAY DIFFRACTION 0.260 0.223 False True IGHV1 NA NA None None None None None 6tnp I G 0 I unknown NO8 unknown IMMUNE SYSTEM 12/09/19 Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide MUS MUSCULUS mus musculus mus musculus mus musculus Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. 3.0 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV8 Kappa None None None None None 4k7p Y X 0 IMMUNE SYSTEM 04/17/13 Generation and Characterization of a Unique Reagent that Recognizes a Panel of Recombinant Human Monoclonal Antibody Therapeutics in the Presence of Endogenous Human IgG MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Shia, S. 2.95 X-RAY DIFFRACTION 0.284 0.219 False True IGHV3 IGKV1 Kappa None None None None None 1h8o A a 0 ANTIBODY 02/14/01 Selection, characterization and X-ray Structure of anti-ampicillin single chain Fv fragments from phage-displayed murine antibody libraries MUS MUSCULUS mus musculus Burmester, J., Spinelli, S., Pugliese, L., Krebber, A., Honegger, A., Jung, S., Schimmele, B., Cambillau, C., Pluckthun, A. 2.75 X-RAY DIFFRACTION 0.258 0.178 True True unknown unknown unknown None None None None None 6ieb E F 0 B protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R15 HOMO SAPIENS; RIFT VALLEY FEVER VIRUS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 2.409 X-RAY DIFFRACTION 0.246 0.195 False True IGHV4 IGLV3 Lambda None None None None None 4ztp H L 0 IMMUNE SYSTEM 05/14/15 Fab structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Pan, R., Kong, X.-P. 1.63 X-RAY DIFFRACTION 0.228 0.195 False True IGHV1 IGKV1 Kappa None None None None None 4xgz G I 0 g peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 5gmq B C 0 A protein s protein VIRAL PROTEIN/IMMUNE SYSTEM 07/15/16 Structure of MERS-CoV RBD in complex with a fully human antibody MCA1 MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Chen, C., Wang, J.M., Zou, T.T., Gao, X.P., Cui, S., Jin, Q. 2.703 X-RAY DIFFRACTION 0.285 0.239 False True IGHV1 IGKV3 Kappa None None None None None 6k2i A NA 7 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7kbb H L 0 D protein NA envelope glycoprotein ul130 VIRAL PROTEIN/IMMUNE SYSTEM 10/01/20 Cryo-EM structure of the HCMV pentamer bound by Fabs 2-18 and 8I21 HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS homo sapiens homo sapiens human cytomegalovirus Wrapp, D., McLellan, J.S. 4.02 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5mhr R Q 0 A protein NA viral attachment protein sigma 1 IMMUNE SYSTEM 11/25/16 T3D reovirus sigma1 complexed with 9BG5 Fab fragments REOVIRUS SP.; MUS MUSCULUS mus musculus mus musculus reovirus sp. Stehle, T., Dietrich, M.H. 3.0 X-RAY DIFFRACTION 0.247 0.212 False False IGHV1 IGKV4 Kappa None None None None None 5lz0 B NA 0 IMMUNE SYSTEM 09/29/16 Llama nanobody PorM_01 LAMA GLAMA lama glama Duhoo, Y., Leone, P., Roussel, A. 1.6 X-RAY DIFFRACTION 0.232 0.203 False True IGHV1 None None None None None 3u1s H L 0 IMMUNE SYSTEM 09/30/11 Crystal structure of human Fab PGT145, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Diwanji, D., Burton, D.R., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.228 0.195 False True IGHV1 IGKV2 Kappa None None None None None 6y1n H L 0 L Hapten XOP 8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE IMMUNE SYSTEM 02/12/20 Crystal structure of the phosphonate-modified A.5 antibody FAB fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chatziefthimiou, S., Mokrushina, Y., Smirnov, I., Gabibov, A., Wilmanns, M. 2.2 X-RAY DIFFRACTION 0.266 0.216 False True IGHV4 IGLV1 Lambda None None None None None 6df1 H L 0 A peptide leu-ptr IMMUNE SYSTEM 05/13/18 anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with sulfate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Mou, K., Leung, K., Wells, J.A. 2.3 X-RAY DIFFRACTION 0.222 0.203 False True IGHV3 IGKV1 Kappa 2.77e-07 -8.946058216241992 Unknown TBD 4w68 B NA 0 NA NA NA NA IMMUNE SYSTEM 08/20/14 Cytoplasmically Produced Homodimeric Single Domain Antibody (sdAb) C22A/C99V variant against Staphylococcal enterotoxin B (SEB) LAMA GLAMA lama glama George, J., Legler, P.M. 2.0 X-RAY DIFFRACTION 0.242 0.199 False True IGHV1 NA NA None None None None None 7nj4 F NA 0 NA NA NA NA VIRAL PROTEIN 02/16/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 5.84 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5ovw G NA 0 C protein vitamin b12-binding protein TRANSPORT PROTEIN 08/30/17 Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Mireku, S.A., Sauer, M.M., Glockshuber, R., Locher, K.P. 2.653 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 None None None None None 1bfo F E 0 ANTIBODY 05/20/98 CAMPATH-1G IGG2B RAT MONOCLONAL FAB RATTUS RATTUS rattus rattus rattus rattus Cheetham, G.M.T., Hale, G., Waldmann, H., Bloomer, A.C. 2.6 X-RAY DIFFRACTION 0.263 0.192 False False IGHV7 IGKV22 Kappa None None None None None 1zwi A B 0 C protein voltage-gated potassium channel IMMUNE SYSTEM/ION TRANSPORT 06/03/05 Structure of mutant KcsA potassium channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Cordero-Morales, J.F., Cuello, L.G., Zhao, Y., Jogini, V., Cortes, D.M., Roux, B., Perozo, E. 2.5 X-RAY DIFFRACTION 0.256 0.243 False True IGHV1 IGKV5 Kappa None None None None None 2x7l E F 0 R protein hiv rev IMMUNE SYSTEM 03/01/10 Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element UNCLASSIFIED; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 BH10 unclassified unclassified human immunodeficiency virus type 3 DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M. 3.17 X-RAY DIFFRACTION 0.2500 0.2337 False True IGHV1 IGKV1 Kappa None None None None None 5mv4 F G 0 H peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 4xh2 H L 0 h peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD4 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.0 X-RAY DIFFRACTION 0.258 0.224 False True IGHV3 IGKV1 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 5hj3 E F 0 H | G protein | protein NA | NA envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/12/16 Crystal structure of host-primed Ebola virus GP, GPcl. EBOLA VIRUS SP.; ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus | ebola virus sp. Bornholdt, Z.A., Fusco, M.L., Saphire, E.O. 3.3 X-RAY DIFFRACTION 0.258 0.227 False True IGHV3 IGKV4 Kappa None None None None None 7n8h O N 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/14/21 SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5d1z G H 0 J protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT1 bound by clone D4-10 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN MSSA476) homo sapiens homo sapiens staphylococcus aureus (strain mssa476) Deng, X. 3.17 X-RAY DIFFRACTION 0.287 0.233 False True IGHV3 IGKV1 Kappa None None None None None 7kd2 C NA 0 B | A protein | protein NA | NA ricin chain b | ricin chain a TOXIN 10/07/20 Ricin bound to VHH antibody V11B2 VICUGNA PACOS; RICINUS COMMUNIS vicugna pacos ricinus communis | ricinus communis Rudolph, M.J. 2.55 X-RAY DIFFRACTION 0.280 0.227 False True IGHV1 NA NA None None None None None 6hf1 C B 0 A protein sulfhydryl oxidase 1 OXIDOREDUCTASE 08/21/18 Mutant oxidoreductase fragment of mouse QSOX1 in complex with an antibody Fab MUS MUSCULUS mus musculus mus musculus mus musculus Grossman-Haham, I., Fass, D. 1.94 X-RAY DIFFRACTION 0.231 0.194 False True IGHV1 IGKV4 Kappa None None None None None 5kel H L 0 B protein ebola surface glycoprotein, gp2 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 ZAIRE EBOLAVIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV6 IGKV12 Kappa None None None None None 7olz C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 05/20/21 Crystal structure of the SARS-CoV-2 RBD with neutralizing-VHHs Re5D06 and Re9F06 VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 vicugna pacos severe acute respiratory syndrome coronavirus2 Aksu, M., Guttler, T., Gorlich, D. 1.75 X-RAY DIFFRACTION 0.209 0.176 False True IGHV1 NA NA None None None None None 1mie H L 0 IMMUNE SYSTEM 08/23/02 Crystal Structure Of The Fab Fragment of Esterolytic Antibody MS5-393 MUS MUSCULUS mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 1.95 X-RAY DIFFRACTION 0.302 0.219 False True IGHV1 IGKV2 Kappa None None None None None 6ukt E NA 0 A protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 10/05/19 Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., Zhang, K., Johnston, J.D., Chiu, W., Sprang, S.R. 3.87 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6azk D C 0 IMMUNE SYSTEM 09/11/17 Structure of cetuximab with aminoheptanoic acid-linked N-(3-hydroxypropyl)-L-arginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.477 X-RAY DIFFRACTION 0.213 0.170 False True IGHV2 IGKV5 Kappa 2.2999999999999996e-06 -7.691979474199363 Unknown TBD 4ouo A a 0 NA NA NA NA IMMUNE SYSTEM 02/18/14 anti-Bla g 1 scFv GALLUS GALLUS gallus gallus Mueller, G.A., Ankney, J.A., Glesner, J., Khurana, T., Edwards, L.L., Pedersen, L.C., Perera, L., Slater, J.E., Pomes, A., London, R.E. 1.8 X-RAY DIFFRACTION 0.191 0.165 True True unknown unknown unknown None None None None None 7lki D E 0 F peptide NA unknown VIRUS 02/02/21 The crystal structure of Epitope III of HCV envelop protein E2 in complex with antibody 1H8 MUS MUSCULUS; HEPACIVIRUS C Deng, L., Zhang, P. 2.0 X-RAY DIFFRACTION 0.294 0.245 False False IGHV6 IGKV1 Kappa None None None None None 7cwn L J 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4pir I NA 0 C protein 5-hydroxytryptamine receptor 3a TRANSPORT PROTEIN 05/09/14 X-ray structure of the mouse serotonin 5-HT3 receptor MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M.B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X.-D., Poitevin, F., Vogel, H., Nury, H. 3.5 X-RAY DIFFRACTION 0.257 0.217 False True IGHV1 None None None None None 5i16 B A 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV1-69/IGKV3-11 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 1.9 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 IGKV3 Kappa None None None None None 3s37 H L 0 X protein vascular endothelial growth factor receptor 2 IMMUNE SYSTEM/Transferase 05/17/11 Structural basis for the function of two anti-VEGF receptor antibodies MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Franklin, M.C. 2.7 X-RAY DIFFRACTION 0.315 0.282 False True IGHV3 IGKV1 Kappa None None None None None 6uga H L 0 IMMUNE SYSTEM 09/26/19 ch28/11 Fab (monoclinic form) MUS MUSCULUS mus musculus mus musculus Soliman, C., Ramsland, P.A. 2.5 X-RAY DIFFRACTION 0.239 0.164 False True IGHV2 IGKV4 Kappa None None None None None 5vsi H L 0 IMMUNE SYSTEM 05/11/17 CH1/Ckappa Fab mutant 15.1 HOMO SAPIENS homo sapiens homo sapiens Hendle, J. 1.51 X-RAY DIFFRACTION 0.227 0.194 False True IGHV1 IGKV1 Kappa None None None None None 5xp1 NA B 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 7kfw H L 0 A protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B3 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.792 X-RAY DIFFRACTION 0.229 0.189 False True IGHV3 IGKV1 Kappa None None None None None 6u9s A B 0 C protein cd81 antigen CELL ADHESION 05/13/20 Crystal structure of human CD81 large extracellular loop in complex with 5A6 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Susa, K.J., Seegar, T.C.M., Blacklow, S.C.B., Kruse, A.C. 2.4 X-RAY DIFFRACTION 0.281 0.214 False True IGHV7 IGKV2 Kappa None None None None None 5jw4 O P 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment in Complex with H5 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 3.7 X-RAY DIFFRACTION 0.285 0.274 False True IGHV6 IGKV1 Kappa None None None None None 2o5z H L 0 IMMUNE SYSTEM 12/06/06 Crystal structure of the 1E9 LeuH47Trp/ArgH100Trp Fab 5-beta-androstane-3,17-dione complex MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Verdino, P., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.216 0.171 False True IGHV7 IGKV2 Kappa None None None None None 4liq H L 0 E protein macrophage colony-stimulating factor 1 receptor IMMUNE SYSTEM 07/03/13 Structure of the extracellular domain of human CSF-1 receptor in complex with the Fab fragment of RG7155 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Benz, J., Gorr, I.H., Hertenberger, H., Ries, C.H. 2.6 X-RAY DIFFRACTION 0.237 0.186 False True IGHV1 IGKV1 Kappa 2.0000000000000003e-10 -13.231762501782761 SPR TBD 7si0 E F 0 B protein NA ige fc IMMUNE SYSTEM 10/12/21 IgE-Fc in complex with 813 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.261 0.210 False True IGHV3 IGKV1 Kappa None None None None None 6nfn N M 0 M Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 4yhm H L 0 H Hapten 4CC N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine IMMUNE SYSTEM 02/27/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schiele, F., Nar, H. 2.16 X-RAY DIFFRACTION 0.220 0.170 False True IGHV1 IGKV1 Kappa 1.73e-10 -13.317687904901941 Unknown TBD 7o30 H L 0 P peptide NA pas#1 epitope peptide IMMUNE SYSTEM 04/01/21 Crystal structure of the anti-PAS Fab 1.1 in complex with its epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Schilz, J., Schiefner, A., Skerra, A. 2.65 X-RAY DIFFRACTION 0.269 0.220 False True IGHV2 IGKV3 Kappa None None None None None 2kqn NA A 1 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6mlm F G 0 B protein hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 09/27/18 H7 HA0 in complex with Fv from H7.5 IgG INFLUENZA A VIRUS (A/NEW YORK/107/2003(H7N2)); INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/new york/107/2003(h7n2)) Pallesen, J., Turner, H.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7nqa C NA 0 B protein NA nuclear pore complex protein nup96 NUCLEAR PROTEIN 03/01/21 Complex of Nucleoporin-98 and nanobody MS98-27 solved at 1.85A resolution XENOPUS TROPICALIS; VICUGNA PACOS vicugna pacos xenopus tropicalis Sola-Colom, M., Trakhanov, S., Goerlich, D. 2.2 X-RAY DIFFRACTION 0.226 0.176 False True IGHV1 NA NA None None None None None 7mzn H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab PDI 231 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Tan, L.L., Dietrich, M.H., Chan, L.J., Tham, W.H. 3.1 X-RAY DIFFRACTION 0.259 0.223 False True IGHV3 IGKV1 Kappa None None None None None 6xpx B C 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 07/09/20 Human antibody S1V2-51 in complex with the influenza hemagglutinin head domain of A/Aichi/2/1968 (X-31)(H3N2) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus McCarthy, K.R., Harrison, S.C. 2.598 X-RAY DIFFRACTION 0.215 0.185 False True IGHV3 IGKV4 Kappa None None None None None 4fg6 E F 0 B protein h(+)/cl(-) exchange transporter clca transport protein 06/04/12 Structure of EcCLC E148A mutant in Glutamate MUS MUSCULUS; SHIGELLA SONNEI mus musculus mus musculus shigella sonnei Feng, L., MacKinnon, R. 3.019 X-RAY DIFFRACTION 0.274 0.237 False True IGHV4 IGKV4 Kappa None None None None None 4pgj C NA 0 D protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/02/14 Human heavy-chain domain antibody in complex with hen egg-white lysozyme HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Christ, D., Langley, D.B., Rouet, R. 2.6 X-RAY DIFFRACTION 0.287 0.225 False True IGHV3 2.6e-08 -10.347827778050062 SPR TBD 4zs7 H L 0 A protein interleukin-6 IMMUNE SYSTEM 05/13/15 Structural mimicry of receptor interaction by antagonistic IL-6 antibodies LAMA GLAMA; HOMO SAPIENS lama glama lama glama homo sapiens Blanchetot, C., De Jonge, N., Desmyter, A., Ongenae, N., Hofman, E., Klarenbeek, A., Sadi, A., Hultberg, A., Kretz-Rommel, A., Spinelli, S., Loris, R., Cambillau, C., de Haard, H. 2.93 X-RAY DIFFRACTION 0.293 0.261 False True IGHV4 IGLV2 Lambda 2.1e-11 -14.567099215178107 SPR TBD 1mcc NA B 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-nh2 IMMUNE SYSTEM 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown 0.199 False True IGLV2 Lambda None None None None None 5ukb c NA 0 C protein nucleocapsid Viral Protein/RNA/Immune System 01/20/17 VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 ESCHERICHIA COLI; VESICULAR STOMATITIS INDIANA VIRUS; VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 5.473 X-RAY DIFFRACTION 0.338 0.336 False False IGHV1 None None None None None 3rif F N 0 B protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.345 X-RAY DIFFRACTION 0.271 0.248 False True IGHV1 IGLV1 Lambda None None None None None 6gfe K M 0 IMMUNE SYSTEM 04/30/18 High-resolution Structure of a therapeutic full-length anti-NPRA Antibody with exceptional Conformational Diversity HOMO SAPIENS homo sapiens homo sapiens Hoerer, S. 1.8 X-RAY DIFFRACTION 0.200 0.181 False True IGHV6 IGKV3 Kappa None None None None None 1him L H 0 P peptide influenza hemagglutinin ha1 (strain x47)(residues 100-108) IMMUNOGLOBULIN 07/08/92 STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION MUS MUSCULUS mus musculus mus musculus Schulze-Gahmen, U., Wilson, I.A. 2.9 X-RAY DIFFRACTION unknown 0.200 False True IGHV5 IGKV8 Kappa None None None None None 5mth A B 0 IMMUNE SYSTEM 01/09/17 Structure of DC8E8 Fab at pH 6.5 crystallized in spacegroup P21 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 1.73 X-RAY DIFFRACTION 0.236 0.185 False False IGHV1 IGKV8 Kappa None None None None None 7epb C NA 0 A protein NA metabotropic glutamate receptor 2 MEMBRANE PROTEIN 04/26/21 Cryo-EM structure of LY354740-bound mGlu2 homodimer HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Du, J., Wang, D., Fan, H., Tai, L., Lin, S., Han, S., Sun, F., Wu, B., Zhao, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 43c9 D C 0 IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY MUS MUSCULUS mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.2 X-RAY DIFFRACTION 0.265 0.210 False True IGHV2 IGKV8 Kappa None None None None None 6h06 C D 0 G peptide microtubule-associated protein tau IMMUNE SYSTEM 07/06/18 FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Juraszek, J., Steinbacher, S. 2.63 X-RAY DIFFRACTION 0.270 0.216 False True IGHV1 IGKV2 Kappa 5.6e-06 -7.164753442850797 Unknown TBD 7fau D NA 0 C protein NA spike protein s1 STRUCTURAL PROTEIN 07/07/21 Structure Determination of the NB1B11-RBD Complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELIDAE camelidae severe acute respiratory syndrome coronavirus2 Shi, Z.Z., Li, X.X., Wang, L., Sun, Z.C., Zhang, H.W., Chen, X.C., Cui, Q.Q., Qiao, H.R., Lan, Z.Y., Zhang, X. 2.08 X-RAY DIFFRACTION 0.228 0.198 False True IGHV1 NA NA None None None None None 7kn4 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-E6 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.291 0.241 False True IGHV4 IGLV1 Lambda None None None None None 4yfl F I 0 E protein envelope glycoprotein gp160,envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 02/25/15 Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Zhou, T., Moquin, S., Kwong, P.D. 3.387 X-RAY DIFFRACTION 0.326 0.268 False True unknown IGLV1 Lambda None None None None None 1q0y H L 0 IMMUNE SYSTEM 07/17/03 Anti-Morphine Antibody 9B1 Complexed with Morphine MUS MUSCULUS mus musculus mus musculus Pozharski, E., Wilson, M.A., Hewagama, A., Shanafelt, A.B., Petsko, G., Ringe, D. 2.0 X-RAY DIFFRACTION 0.239 0.194 False False IGHV1 IGLV1 Lambda None None None None None 6ozc P R 0 F carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN 05/20/20 BG505 SOSIP.664 with 2G12 Fab2 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.79 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7tm0 L M 0 C protein NA spike glycoprotein VIRUS 01/19/22 SARS-CoV-2 S B.1.1.529 Omicron variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6pzw K I 0 D protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-22 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 1tqc B C 0 A protein prion protein UNKNOWN FUNCTION/IMMUNE SYSTEM 06/17/04 Ovine recombinant PrP(114-234), ARR variant in complex with the VRQ14 Fab fragment (IgG2a) OVIS ARIES; MUS MUSCULUS mus musculus mus musculus ovis aries Eghiaian, F., Grosclaude, J., Lesceu, S., Debey, P., Doublet, B., Treguer, E., Rezaei, H., Knossow, M. 2.8 X-RAY DIFFRACTION 0.288 0.222 False True IGHV9 IGKV1 Kappa None None None None None 4hbc H L 0 IMMUNE SYSTEM 09/27/12 Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Arai, H. 1.54 X-RAY DIFFRACTION 0.259 0.197 False True IGHV1 IGKV1 Kappa None None None None None 6bft H L 0 C protein vascular endothelial growth factor a IMMUNE SYSTEM 10/27/17 Structure of Bevacizumab Fab mutant in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Christie, M., Christ, D. 2.55 X-RAY DIFFRACTION 0.220 0.170 False True IGHV3 IGKV1 Kappa None None None None None 3jbe 7 NA 0 3 protein capsid protein vp3 VIRUS/IMMUNE SYSTEM 08/26/15 Complex of poliovirus with VHH PVSS8A CAMELUS DROMEDARIUS; HUMAN POLIOVIRUS 1 MAHONEY camelus dromedarius human poliovirus 1 mahoney Strauss, M., Schotte, L., Thys, B., Filman, D.J., Hogle, J.M. 4.2 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6ss4 H L 0 A protein NA unknown PROTEIN BINDING 09/06/19 Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021181 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 2.9 X-RAY DIFFRACTION 0.318 0.266 False False IGHV3 IGLV1 Lambda None None None None None 4why I J 0 A peptide epitope peptide VIRAL PROTEIN 09/24/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P21 crystal form RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.62 X-RAY DIFFRACTION 0.258 0.204 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 7djz A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/22/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW01 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M. 2.397 X-RAY DIFFRACTION 0.230 0.183 False True IGHV1 IGKV3 Kappa None None None None None 6n4y F NA 0 A protein metabotropic glutamate receptor 5 MEMBRANE PROTEIN 11/20/18 Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K. 3.262 X-RAY DIFFRACTION 0.251 0.199 False True IGHV1 None None None None None 5tok E NA 0 A protein fusion glycoprotein f0, fibritin chimera VIRAL PROTEIN/IMMUNE SYSTEM 10/17/16 Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66 HUMAN RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama human respiratory syncytial virus Gilman, M.S.A., Kabeche, S.C., McLellan, J.S. 3.8 X-RAY DIFFRACTION 0.286 0.248 False True IGHV1 None None None None None 6dwi F E 0 NA NA NA NA IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 3gnm H L 0 IMMUNE SYSTEM 03/17/09 The crystal structure of the JAA-F11 monoclonal antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Gulick, A.M., Rittenhouse-Olson, K., Jadey, S. 2.1 X-RAY DIFFRACTION 0.263 0.185 False False IGHV1 IGKV1 Kappa None None None None None 4r7n Q R 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 3u79 NA B 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 7d3s N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 09/20/20 Human SECR in complex with an engineered Gs heterotrimer HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; UNIDENTIFIED; SYNTHETIC CONSTRUCT unidentified homo sapiens | rattus norvegicus | bos taurus Fukuhara, S., Kobayashi, K., Kusakizako, T., Shihoya, W., Nureki, O. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5wdu H I 0 A protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True unknown unknown unknown None None None None None 5jw4 U V 0 J | I protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment in Complex with H5 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 3.7 X-RAY DIFFRACTION 0.285 0.274 False True IGHV6 IGKV1 Kappa None None None None None 1nd0 B A 0 A Hapten DP4 (1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE 1-OXIDE IMMUNE SYSTEM 12/05/02 CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.286 0.242 False False IGHV3 IGKV1 Kappa None None None None None 2kqm NA B 5 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6qu9 A B 0 PROTEIN BINDING 02/26/19 Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin MUS MUSCULUS mus musculus mus musculus Jagger, A.M., Heyer-Chauhan, N., Lomas, D.A., Irving, J.A. 1.9 X-RAY DIFFRACTION 0.233 0.202 False False IGHV1 IGKV19 Kappa None None None None None 6wx2 A B 0 C peptide NA fusion peptide IMMUNE SYSTEM/VIRAL PROTEIN 05/09/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with F60P mutation on light chain in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.39 X-RAY DIFFRACTION 0.250 0.200 False True IGHV1 IGKV1 Kappa None None None None None 6kx1 A B 0 C peptide NA synthetic muc1 glycopepide IMMUNE SYSTEM 09/09/19 Crystal structure of SN-101 mAb in complex with MUC1 glycopeptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Wakui, H., Tanaka, Y., Kato, K., Ose, T., Matsumoto, I., Min, Y., Tachibana, T., Nishimura, S.-I. 1.773 X-RAY DIFFRACTION 0.229 0.177 False True IGHV6 IGKV1 Kappa None None None None None 6n1w H L 0 D protein envelope glycoprotein gp41 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV4 IGKV1 Kappa None None None None None 7ndd D E 0 C protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-159 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7bm5 H L 0 NA NA NA NA IMMUNE SYSTEM 01/19/21 Crystal structure of Fab1, the Fab fragment of the anti-BamA monoclonal antibody MAB1 HOMO SAPIENS homo sapiens homo sapiens White, P., Storek, K.M., Rutherford, S.T., Radford, S.E. 2.95 X-RAY DIFFRACTION 0.290 0.257 False True IGHV5 IGKV12 Kappa None None None None None 7sbu H L 0 A protein NA spike protein s1 IMMUNE SYSTEM 09/25/21 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a highly potent antibody J08 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Wilson, I.A. 2.53 X-RAY DIFFRACTION 0.261 0.220 False True IGHV1 IGKV3 Kappa None None None None None 7mw2 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with all RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5nbw B A 0 A Hapten 8SK benzo[a]pyren-3-ol IMMUNE SYSTEM 03/02/17 Crystal structure of the Fab fragment 22F12 in complex with 3-hydroxybenzo[a]pyrene MUS MUSCULUS mus musculus mus musculus mus musculus Skerra, A., Eichinger, A. 2.4 X-RAY DIFFRACTION 0.228 0.180 False True IGHV1 IGKV14 Kappa None None None None None 7nks C D 0 B protein NA envelope polyprotein VIRAL PROTEIN 02/18/21 Structure of the Hantaan virus Gn glycoprotein ectodomain in complex with Fab HTN-Gn1 HANTAAN ORTHOHANTAVIRUS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus hantaan orthohantavirus Rissanen, I., Bowden, T.A., Huiskonen, J.T., Stass, R. 3.5 X-RAY DIFFRACTION 0.274 0.224 False True IGHV1 IGKV1 Kappa None None None None None 6p65 F G 0 E protein hiv env 16055 nfl td 2cc+ VIRAL PROTEIN/immune system 05/31/19 HIV Env 16055 NFL TD 2CC+ in complex with antibody 1C2 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.94 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6ldw B A 0 D peptide NA ile-phe-glu-lys-phe-gly-m3l-gly-gly IMMUNE SYSTEM 11/23/19 Structure of antibody C9 in complex with methylated peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Caaveiro, J.M.M., Tsumoto, K. 1.6 X-RAY DIFFRACTION 0.235 0.171 False True IGHV1 IGKV1 Kappa None None None None None 5myo D C 0 IMMUNE SYSTEM 01/27/17 Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Parthier, C., Piechotta, A., Stubbs, M.T. 1.59 X-RAY DIFFRACTION 0.215 0.178 False True IGHV1 IGKV1 Kappa 2.93e-11 -14.369763591907674 Unknown TBD 7jwp G H 0 T peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 2zkh H L 0 IMMUNE SYSTEM 03/21/08 Human thrombopoietin neutralizing antibody TN1 FAB HOMO SAPIENS homo sapiens homo sapiens Arai, S., Tamada, T., Honjo, E., Maeda, Y., Kuroki, R. 2.04 X-RAY DIFFRACTION 0.232 0.193 False True IGHV6 IGKV4 Kappa None None None None None 6yax H L 0 A protein NA unknown IMMUNE SYSTEM 03/14/20 Crystal structure of CD32b (Fc Gamma Receptor IIb) in complex with Human IgG1 Fab fragment (5C05) HOMO SAPIENS Fisher, H., Tews, I., Orr, C. 2.8 X-RAY DIFFRACTION 0.264 0.230 False False IGHV3 IGLV1 Lambda None None None None None 6ele A B 0 IMMUNE SYSTEM 09/28/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 1.78 X-RAY DIFFRACTION 0.218 0.190 False True IGHV4 IGKV1 Kappa None None None None None 2mkw NA A 1 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6obd H L 0 F peptide gld52 peptide mimetic IMMUNE SYSTEM 03/20/19 Crystal structure of anti-GLD52 Fab complex with human GLD52 peptide mimetic MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Wei, R. 2.2 X-RAY DIFFRACTION 0.307 0.234 False True IGHV3 IGKV1 Kappa None None None None None 6kva H L 0 B peptide NA peptide from c-x-c chemokine receptor type 2 IMMUNE SYSTEM 09/03/19 Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Xiang, J.C., Yan, L., Yang, B., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.235 0.194 False True IGHV1 IGLV5 Lambda None None None None None 6nz7 G I 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 02/13/19 Crystal structure of broadly neutralizing Influenza A antibody 429 B01 in complex with Hemagglutinin Hong Kong 1968 INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Zhou, T., Kwong, P.D. 2.95 X-RAY DIFFRACTION 0.267 0.224 False True IGHV3 IGKV1 Kappa None None None None None 5g5x B NA 0 A protein site-2 protease HYDROLASE 06/09/16 CBS domain tandem of site-2 protease from Archaeoglobus fulgidus in complex with llama Nanobody - nucleotide-bound form LAMA GLAMA; ARCHAEOGLOBUS FULGIDUS lama glama archaeoglobus fulgidus Schacherl, M., Baumann, U. 2.8 X-RAY DIFFRACTION 0.269 0.246 False True IGHV1 None None None None None 4jo3 H L 0 P peptide gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/16/13 Crystal structure of rabbit mAb R20 Fab in complex with V3 C-terminus of HIV-1 Consensus B gp120 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R.M., Kong, X.P. 2.6 X-RAY DIFFRACTION 0.234 0.184 False True IGHV1 IGKV1 Kappa None None None None None 5cex D C 0 IMMUNE SYSTEM 07/07/15 Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies HOMO SAPIENS homo sapiens homo sapiens Garces, F., Wilson, I.A. 2.105 X-RAY DIFFRACTION 0.244 0.200 False True IGHV4 IGLV3 Lambda None None None None None 7pi2 K L 0 J protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to monoclonal antibody Cy.003 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 3.14 X-RAY DIFFRACTION 0.239 0.219 False True unknown unknown unknown None None None None None 1a7n H L 0 IMMUNOGLOBULIN 03/16/98 FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) VARIANT FOR CHAIN L GLU81->ASP AND CHAIN H LEU312->VAL MUS MUSCULUS mus musculus mus musculus Marks, C., Henrick, K., Winter, G. 2.01 X-RAY DIFFRACTION unknown 0.155 False True IGHV2 IGKV12 Kappa None None None None None 6ck8 B NA 0 IMMUNE SYSTEM 02/27/18 Crystal structure of anti-influenza single-domain llama antibody SD38 LAMA GLAMA lama glama Zhu, X., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.211 0.177 False True IGHV1 None None None None None 7rlv A B 0 P peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRADGQPAGDRADGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.2 X-RAY DIFFRACTION 0.220 0.179 False True IGHV1 IGKV1 Kappa None None None None None 5ggr A B 0 Y protein programmed cell death protein 1 IMMUNE SYSTEM 06/16/16 PD-1 in complex with nivolumab Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heo, Y.S. 3.3 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGKV3 Kappa None None None None None 5nj6 H L 0 A protein proteinase-activated receptor 2,soluble cytochrome b562,proteinase-activated receptor 2 MEMBRANE PROTEIN 03/28/17 Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in ternary complex with Fab3949 and AZ7188 at 4.0 angstrom resolution MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens, escherichia coli Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N. 4.0 X-RAY DIFFRACTION 0.319 0.263 False True IGHV5 IGKV4 Kappa None None None None None 5vj6 M N 0 B protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/18/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 11.5 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6qn7 H L 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV hybrid Fab B4HC-B13LC BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.15 X-RAY DIFFRACTION 0.234 0.203 False True IGHV1 IGLV1 Lambda None None None None None 6ze1 B NA 0 A protein NA cystic fibrosis transmembrane conductance regulator HYDROLASE 06/15/20 human NBD1 of CFTR in complex with nanobody G11a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Garcia-Pino, A., Govaerts, C., Scholl, D., Sigoillot, M. 2.705 X-RAY DIFFRACTION 0.258 0.207 False True unknown unknown unknown None None None None None 1axs B A 0 B Hapten HOP (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL CATALYTIC ANTIBODY 10/20/97 MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mundorff, E.C., Ulrich, H.D., Stevens, R.C. 2.6 X-RAY DIFFRACTION 0.305 0.200 False True IGHV1 IGKV14 Kappa 1.7e-08 -10.599564136380756 Unknown TBD 6xcj H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/08/20 Crystal Structure of DH650 Fab from a Rhesus Macaque in Complex with HIV-1 gp120 Core HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Raymond, D.D., Chug, H., Harrison, S.C. 2.8 X-RAY DIFFRACTION 0.284 0.227 False True IGHV1 IGKV2 Kappa None None None None None 6uig B C 0 A protein NA hemagglutinin ANTIVIRAL PROTEIN 09/30/19 Crystal structure of human monoclonal antibody H7.200 in complex with H7N9 hemagglutinin HA1 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Dong, J., Crowe, J.E. 3.2 X-RAY DIFFRACTION 0.234 0.207 False True IGHV4 IGKV1 Kappa None None None None None 5bk1 H L 0 A protein maltose binding protein SUGAR BINDING PROTEIN 09/12/17 Crystal structure of maltose binding protein in complex with an endosteric synthetic antibody HOMO SAPIENS; ESCHERICHIA COLI homo sapiens homo sapiens escherichia coli Mukherjee, S., Kossiakoff, A.A. 2.15 X-RAY DIFFRACTION 0.253 0.205 False True IGHV3 IGKV1 Kappa 1.1000000000000001e-09 -12.22172707862036 SPR TBD 6idh H L 0 IMMUNE SYSTEM 09/10/18 Antibody 64M-5 Fab in ligand-free form MUS MUSCULUS mus musculus mus musculus Yokoyama, H., Mizutani, R., Noguchi, S., Hayashida, N. 2.5 X-RAY DIFFRACTION 0.281 0.229 False False IGHV1 IGKV1 Kappa None None None None None 7p6k H NA 0 D protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/16/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb5 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4xwo C D 0 A protein sec22 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 7bm5 I G 0 NA NA NA NA IMMUNE SYSTEM 01/19/21 Crystal structure of Fab1, the Fab fragment of the anti-BamA monoclonal antibody MAB1 HOMO SAPIENS homo sapiens homo sapiens White, P., Storek, K.M., Rutherford, S.T., Radford, S.E. 2.95 X-RAY DIFFRACTION 0.290 0.257 False True IGHV5 IGKV12 Kappa None None None None None 7cwu H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7stz I M 0 D protein NA cadherin-1 cell adhesion/immune system 11/15/21 Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.95 X-RAY DIFFRACTION 0.208 0.182 False True IGHV2 IGKV8 Kappa None None None None None 7lab Y X 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/06/21 Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1052 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5f97 H NA 0 D protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group A type 1 hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.62 X-RAY DIFFRACTION 0.237 0.188 False True IGHV1 None None None None None 7deo A a 0 B protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 11/04/20 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens severe acute respiratory syndrome coronavirus2 Fu, D., Zhang, G., Li, X., Rao, Z., Guo, Y. 2.5 X-RAY DIFFRACTION 0.232 0.187 True True unknown unknown unknown None None None None None 3qcv I M 0 I Hapten 18L (2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL (9Z,12Z)-OCTADECA-9,12-DIENOATE IMMUNE SYSTEM 01/17/11 Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (18:2) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fleming, J.K., Wojciak, J.M., Campbell, M.-A., Huxford, T. 2.51 X-RAY DIFFRACTION 0.266 0.215 False True IGHV5 IGKV2D Kappa None None None None None 4wht C D 0 c peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 4nby B NA 0 A protein cell wall-binding repeat protein IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A2 Bound to Two Molecules of A20.1 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E., Klassen, J.S., Ng, K.K.S. 2.08 X-RAY DIFFRACTION 0.255 0.209 False True IGHV1 None None None None None 6nfv A B 0 C protein ph-gated potassium channel kcsa membrane protein, metal transport 12/20/18 Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Tilegenova, C., Cortes, D.M., Jahovic, N., Hardy, E., Parameswaran, H., Guan, L., Cuello, L.G. 2.13 X-RAY DIFFRACTION 0.243 0.206 False True IGHV1 IGKV5 Kappa None None None None None 5ogi B b 0 A protein hexon protein VIRAL PROTEIN 07/13/17 Complex of a binding protein and human adenovirus C 5 hexon MUS MUSCULUS; HUMAN ADENOVIRUS C SEROTYPE 5 mus musculus human adenovirus c serotype 5 Schmid, M., Ernst, P., Honegger, A., Suomalainen, M., Zimmermann, M., Braun, L., Stauffer, S., Thom, C., Dreier, B., Eibauer, M., Kipar, A., Vogel, V., Greber, U.F., Medalia, O., Plueckthun, A. 2.8 X-RAY DIFFRACTION 0.235 0.198 True True unknown unknown unknown None None None None None 6xv8 A NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/21/20 Crystal structure of Megabody Mb-Nb207-c7HopQ_G10 LAMA GLAMA; HELICOBACTER PYLORI (STRAIN G27) lama glama, helicobacter pylori (strain g27) Steyaert, J., Uchanski, T., Fischer, B. 3.15 X-RAY DIFFRACTION 0.297 0.255 False True IGHV1 NA NA None None None None None 1uwe Y X 0 ANTIBODY 02/05/04 MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9 MUS MUSCULUS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Baumann, U., Reymond, J.L. 2.67 X-RAY DIFFRACTION 0.271 0.218 False True IGHV1 IGKV6 Kappa None None None None None 4k3h NA H 0 G Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 5ezi H L 0 IMMUNE SYSTEM 11/26/15 Crystal Structure of Fab of parasite invasion inhibitory antibody c1 - hexagonal form HOMO SAPIENS homo sapiens homo sapiens Favuzza, A., Pluschke, G., Rudolph, M.G. 1.61 X-RAY DIFFRACTION 0.221 0.195 False True IGHV4 IGKV6 Kappa None None None None None 5hdq H L 0 A protein abc transporter substrate-binding protein Transport protein/Immune System 01/05/16 MntC co-structure with mAB 305-78-7 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Parris, K., Mosyak, L. 1.83 X-RAY DIFFRACTION 0.236 0.207 False True IGHV1 IGKV8 Kappa 1.2e-09 -12.170174257779676 SPR TBD 1mqk H L 0 IMMUNE SYSTEM 09/16/02 Crystal structure of the unliganded Fv-fragment of the anti-cytochrome C oxidase antibody 7E2 MUS MUSCULUS mus musculus mus musculus Essen, L.-O., Harrenga, A., Ostermeier, C., Michel, H. 1.28 X-RAY DIFFRACTION unknown unknown False True IGHV5 IGKV12 Kappa None None None None None 7f4h N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/18/21 Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16 HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ma, S., Chen, Y., Dai, A., Yin, W., Guo, J., Yang, D., Zhou, F., Jiang, Y., Wang, M.-W., Xu, H.E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7ps1 A B 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-27 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.4 X-RAY DIFFRACTION 0.215 0.184 False True IGHV3 IGKV3 Kappa None None None None None 5a8h R Q 0 M protein NA hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 23.0 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6fe4 J NA 0 E protein shiga-like toxin 2 subunit b TOXIN 12/29/17 Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113 ENTEROBACTERIA PHAGE 933W; VICUGNA PACOS vicugna pacos enterobacteria phage 933w Bernedo, R., Muyldermans, S., Sterckx, Y.G.J. 3.0 X-RAY DIFFRACTION 0.207 0.169 False True IGHV3 9.6e-09 -10.938139080820335 SPR TBD 6h2y H L 0 D protein lipoprotein gna1870 IMMUNE SYSTEM 07/17/18 human Fab 1E6 bound to fHbp variant 3 from Neisseria meningitidis serogroup B NEISSERIA MENINGITIDIS; HOMO SAPIENS homo sapiens homo sapiens neisseria meningitidis Veggi, D., Bianchi, F., Cozzi, R., Malito, E., Bottomley, M.J. 2.65 X-RAY DIFFRACTION 0.275 0.205 False True IGHV1 IGLV3 Lambda None None None None None 7ws5 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7km5 C NA 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/20 Crystal structure of SARS-CoV-2 RBD complexed with Nanosota-1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Ye, G., Shi, K., Aihara, H., Li, F. 3.19 X-RAY DIFFRACTION 0.294 0.247 False True IGHV1 NA NA None None None None None 1mcw NA W 0 IMMUNOGLOBULIN 05/09/89 THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY HOMO SAPIENS homo sapiens Ely, K.R., Herron, J.N., Edmundson, A.B. 3.5 X-RAY DIFFRACTION unknown unknown False False IGLV2 Lambda None None None None None 1j1x H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 12/20/02 Crystal Structure of HyHEL-10 Fv mutant LS93A complexed with hen egg white lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Yokota, A., Tsumoto, K., Shiroishi, M., Kondo, H., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.217 0.189 False True IGHV3 IGKV5 Kappa None None None None None 5mhr M L 0 D protein NA viral attachment protein sigma 1 IMMUNE SYSTEM 11/25/16 T3D reovirus sigma1 complexed with 9BG5 Fab fragments REOVIRUS SP.; MUS MUSCULUS mus musculus mus musculus reovirus sp. Stehle, T., Dietrich, M.H. 3.0 X-RAY DIFFRACTION 0.247 0.212 False False IGHV1 IGKV4 Kappa None None None None None 3dif B A 0 IMMUNE SYSTEM 06/20/08 Crystal structure of FabOX117 HOMO SAPIENS homo sapiens homo sapiens Nettleship, J.E., Ren, J., Owens, R.J., Oxford Protein Production Facility (OPPF) 2.4 X-RAY DIFFRACTION 0.286 0.219 False True IGHV1 IGKV6 Kappa None None None None None 5fgb E B 0 G peptide genome polyprotein IMMUNE SYSTEM 12/20/15 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.4 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus genotype 1a (isolate h) Girard-Blanc, C., Rey, F.A., Krey, T. 1.65 X-RAY DIFFRACTION 0.190 0.171 False True IGHV3 IGLV3 Lambda None None None None None 7f1g D NA 0 A protein NA beta-secretase 2 HYDROLASE 06/09/21 BACE2 xaperone complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-2H,3H-[1,4]dioxino[2,3-c]pyridine-7-carboxamide HOMO SAPIENS homo sapiens homo sapiens Ueno, T., Matsuoka, E., Asada, N., Yamamoto, S., Kanegawa, N., Ito, M., Ito, H., Moechars, D., Rombouts, F.J.R., Gijsen, H.J.M., Kusakabe, K.I. 1.5 X-RAY DIFFRACTION 0.245 0.226 False True IGHV3 NA NA None None None None None 7zfa O P 0 B protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV3 IGKV1 Kappa None None None None None 1xgy H L 0 P peptide rhodopsin epitope mimetic peptide immune system 09/17/04 Crystal Structure of Anti-Meta I Rhodopsin Fab Fragment K42-41L MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Piscitelli, C.L., Angel, T.E., Bailey, B.W., Lawerence, C.M. 2.71 X-RAY DIFFRACTION 0.272 0.233 False False IGHV1 IGKV2 Kappa None None None None None 4at6 G I 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 2gsi H G 0 Z peptide thermonuclease IMMUNE SYSTEM 04/26/06 Crystal Structure of a Murine Fab in Complex with an 11 Residue Peptide Derived from Staphylococcal Nuclease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Armstrong, A.A., Amzel, L.M. 2.81 X-RAY DIFFRACTION 0.293 0.221 False False IGHV14 IGKV3 Kappa None None None None None 7m2i A B 0 C protein NA ph-gated potassium channel kcsa TRANSPORT PROTEIN/IMMUNE SYSTEM 03/16/21 Structural Snapshots of Intermediates in the Gating of a K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Reddi, R., Valiyaveetil, F.I. 2.695 X-RAY DIFFRACTION 0.251 0.228 False True IGHV1 IGKV5 Kappa None None None None None 6p67 E F 0 G protein NA interleukin-7 receptor subunit alpha IMMUNE SYSTEM 06/03/19 Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Walsh, S.T.R., Kashi, L., Kohnhorst, C.L. 2.9 X-RAY DIFFRACTION 0.266 0.249 False True IGHV1 IGKV6 Kappa None None None None None 3mnw B A 0 P peptide gp41 IMMUNE SYSTEM 04/22/10 Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide in a helical conformation MUS MUSCULUS,HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus,homo sapiens mus musculus,homo sapiens human immunodeficiency virus 1 Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 2.2 X-RAY DIFFRACTION 0.253 0.181 False True IGHV9 IGKV8 Kappa None None None None None 7jxd C D 0 NA NA NA NA IMMUNE SYSTEM 08/27/20 Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology HOMO SAPIENS homo sapiens homo sapiens Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.5 X-RAY DIFFRACTION 0.259 0.203 False True IGHV3 IGLV6 Lambda None None None None None 5hhv H L 0 A protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 2.2 X-RAY DIFFRACTION 0.236 0.198 False True IGHV3 IGLV6 Lambda None None None None None 7vqx N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 10/21/21 Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus Xu, Y.N., Feng, W.B., Zhou, Q.T., Liang, A.Y., Li, J., Dai, A.T., Zhao, F.H., Yan, J.H., Chen, C.W., Li, H., Zhao, L.H., Xia, T., Jiang, Y., Xu, H.E., Yang, D.H., Wang, M.W. 2.74 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6d6t J I 0 B protein gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 04/22/18 Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, S., Noviello, C.M., Teng, J., Walsh Jr, R.M., Kim, J.J., Hibbs, R.E. 3.8 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa 6.1e-09 -11.20681521904132 Unknown TBD 7cwm H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 Complex of SARS-CoV-2 spike protein and Fab P17 with one RBD in open state and two RBD in closed state SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5wtt H L 0 P peptide epitope peptide of cyr61 PROTEIN BINDING 12/14/16 Structure of the 093G9 Fab in complex with the epitope peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens homo sapiens Zhong, C., Hu, K., Shen, J., Ding, J. 2.7 X-RAY DIFFRACTION 0.274 0.222 False True IGHV3 IGKV1 Kappa 2.5e-07 -9.006821321101087 Unknown TBD 4jj5 B A 0 Immune System 03/07/13 CRYSTAL STRUCTURE OF THE Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC for POLY-GLUTAMINE MUS MUSCULUS mus musculus mus musculus Klein, F.A.C., Zeder-Lutz, G., Cousido-Siah, A., Mitschler, A., Katz, A., Eberling, P., Mandel, J.L., Podjarny, A., Trottier, Y. 2.445 X-RAY DIFFRACTION 0.283 0.239 False True IGHV9 IGLV3 Lambda None None None None None 3j2z B A 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m10 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 6h7o C NA 0 A protein beta-1 adrenergic receptor ELECTRON TRANSPORT 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.8 X-RAY DIFFRACTION 0.274 0.240 False True IGHV1 1.4000000000000003e-10 -13.443086585131377 Unknown TBD 5x8l F K 0 A protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 03/03/17 PD-L1 in complex with atezolizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, H.T. 3.1 X-RAY DIFFRACTION 0.256 0.208 False True IGHV3 IGKV1 Kappa None None None None None 6um5 K L 0 I protein ch848 10.17 dt gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunders, K.O., Haynes, B.F. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 6mh2 B A 0 IMMUNE SYSTEM 09/17/18 Structure of Herceptin Fab without antigen HOMO SAPIENS homo sapiens homo sapiens Luthra, A., Langley, D.B., Christie, M., Christ, D. 2.8 X-RAY DIFFRACTION 0.306 0.251 False True IGHV3 IGKV1 Kappa None None None None None 6b0a H L 0 A protein 25 kda ookinete surface antigen IMMUNE SYSTEM 09/14/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1269 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum Scally, S.W., McLeod, B., Bosch, A., King, C.R., Julien, J.P. 2.5 X-RAY DIFFRACTION 0.249 0.217 False True IGHV3 IGKV3 Kappa 3.7000000000000005e-09 -11.503030961041175 BLI TBD 4f2m A B 0 E protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 05/08/12 Crystal structure of a TGEV coronavirus Spike fragment in complex with the TGEV neutralizing monoclonal antibody 1AF10 TGEV VIRULENT PURDUE; MUS MUSCULUS mus musculus mus musculus tgev virulent purdue Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M. 3.0 X-RAY DIFFRACTION 0.251 0.216 False True IGHV1 IGKV5 Kappa None None None None None 1c1e H L 0 H Hapten ENH 1,7,8,9,10,10-HEXACHLORO-4-METHYL-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE IMMUNE SYSTEM 07/22/99 CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN MUS MUSCULUS mus musculus mus musculus mus musculus Xu, J., Wilson, I.A. 1.9 X-RAY DIFFRACTION 0.294 0.239 False False IGHV9 IGKV1 Kappa None None None None None 4xcf H L 0 P peptide modified fragment of hiv-1 glycoprotein (gp41) includingthe mper region 671-683 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41; crystals cryoprotected with phosphatidylcholine (03:0 PC) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Stanfield, R.L., Wilson, I.A. 1.43 X-RAY DIFFRACTION 0.170 0.137 False True IGHV1 IGKV3 Kappa None None None None None 4plk D C 0 B protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 05/18/14 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12 HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Li, S.W., Sivaraman, J. 4.0 X-RAY DIFFRACTION 0.296 0.264 False False IGHV1 IGKV12 Kappa None None None None None 7d6i B C 0 A protein NA sars-cov-2 receptor binding domain ANTIVIRAL PROTEIN,IMMUNE SYSTEM 09/30/20 A neutralizing MAb targeting receptor-binding-domain of SARS-CoV-2 SEVERE ACUTE RESPIRATORY SYNDROME-RELATED CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Shi, R., Qi, J.X., Gao, G.F., Yan, J.H. 3.41 X-RAY DIFFRACTION 0.255 0.226 False True IGHV3 IGLV6 Lambda None None None None None 6gwn C NA 0 A protein plasminogen activator inhibitor 1 HYDROLASE 06/25/18 Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 2.03 X-RAY DIFFRACTION 0.250 0.208 False True IGHV1 None None None None None 7kqi A C 0 B protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/16/20 Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses HOMO SAPIENS; INFLUENZA B VIRUS homo sapiens homo sapiens influenza b virus Bajic, G., Harrison, S.C. 4.2 X-RAY DIFFRACTION 0.420 0.372 False True IGHV3 IGKV1 Kappa None None None None None 6xob M N 0 B protein NA togavirin Virus/Immune System 07/06/20 CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP with Fab EEEV-143. EASTERN EQUINE ENCEPHALITIS VIRUS; HOMO SAPIENS homo sapiens homo sapiens eastern equine encephalitis virus Binshtein, E., Crowe, J.E. 8.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7wk9 c d 0 C protein NA heavy chain of s3h3 fab VIRAL PROTEIN 01/08/22 SARS-CoV-2 Omicron open state spike protein in complex with S3H3 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Hong, Q., Cong, Y. 3.48 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 5viy J I 0 D protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 6.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 4dw2 H L 0 U protein urokinase-type plasminogen activator HYDROLASE/IMMUNE SYSTEM 02/24/12 The crystal structure of uPA in complex with the Fab fragment of mAb-112 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M. 2.97 X-RAY DIFFRACTION 0.300 0.240 False False IGHV5 IGKV4 Kappa None None None None None 6wju H L 0 NA NA NA NA IMMUNE SYSTEM 04/14/20 Fab Fragment of Anti-human LAG3 antibody (4A10) MUS MUSCULUS mus musculus mus musculus Agnihotri, P., Mishra, A.K., Mariuzza, R.A. 3.1 X-RAY DIFFRACTION 0.287 0.228 False True IGHV14 IGKV2 Kappa None None None None None 3mug B A 0 IMMUNE SYSTEM 05/03/10 Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Pejchal, R., Walker, L.M., Burton, D.R., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGLV2 Lambda None None None None None 5k9k H L 0 F protein hemagglutinin IMMUNE SYSTEM 05/31/16 Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 56.a.09 in complex with Hemagglutinin Hong Kong 1968. HOMO SAPIENS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2) homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.97 X-RAY DIFFRACTION 0.265 0.225 False True IGHV6 IGKV3 Kappa None None None None None 6vrp A a 0 NA NA NA NA PROTEIN BINDING 02/08/20 Reverse Transcriptase Diabody with R83T Mutation HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 1.6 X-RAY DIFFRACTION 0.183 0.146 True True unknown unknown unknown None None None None None 7kgj B NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 10/16/20 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 2.3 X-RAY DIFFRACTION 0.216 0.186 False True IGHV1 NA NA None None None None None 7e8c N P 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4nhg A C 0 IMMUNE SYSTEM 11/05/13 Crystal Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West, Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 8.001 X-RAY DIFFRACTION 0.369 0.359 False True unknown IGKV1 Kappa None None None None None 6qtl G NA 0 D Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 7l7e C D 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV3 IGKV4 Kappa None None None None None 6wwc D H 0 F peptide NA fusion peptide IMMUNE SYSTEM/VIRAL PROTEIN 05/09/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with S48K mutation in light chain in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.563 X-RAY DIFFRACTION 0.267 0.209 False True IGHV1 IGKV1 Kappa None None None None None 1hin H L 0 P peptide influenza hemagglutinin ha1 (strain x47)(residues 100-107) IMMUNOGLOBULIN 07/08/92 STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION MUS MUSCULUS mus musculus mus musculus Rini, J.M., Wilson, I.A. 3.1 X-RAY DIFFRACTION unknown 0.220 False True IGHV5 IGKV8 Kappa None None None None None 6de7 H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 05/11/18 Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Interdomain Stabilization 113C-429GCG in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.123 X-RAY DIFFRACTION 0.258 0.249 False True IGHV4 unknown unknown None None None None None 6oc7 H L 0 IMMUNE SYSTEM 03/22/19 HMP42 Fab in complex with Protein G HOMO SAPIENS; STREPTOCOCCUS SP. GROUP G homo sapiens homo sapiens Bernard, S.M., Wilson, I.A. 1.296 X-RAY DIFFRACTION 0.184 0.168 False True IGHV1 IGLV3 Lambda None None None None None 6bt3 B A 0 N protein NA major capsid protein l1 VIRUS 12/05/17 High-Resolution Structure Analysis of Antibody V5 Conformational Epitope on Human Papillomavirus 16 MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 Guan, J., Bywaters, S.M., Brendle, S.A., Ashley, R.E., Makhov, A.M., Conway, J.F., Christensen, N.D., Hafenstein, S. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 5m95 D NA 0 C protein divalent metal cation transporter mnth TRANSPORT PROTEIN 10/31/16 STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE LAMA GLAMA; STAPHYLOCOCCUS CAPITIS lama glama staphylococcus capitis Ehrnstorfer, I.A., Geertsma, E.R., Pardon, E., Steyaert, J., Dutzler, R. 3.4 X-RAY DIFFRACTION 0.292 0.252 False True IGHV1 None None None None None 7laa H L 0 A protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/06/21 Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1041 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 2xzc H L 0 L Hapten XOP 8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE IMMUNE SYSTEM 11/24/10 Crystal Structure of phosphonate-modified recombinant A.17 antibody FAB fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Carletti, E., Nachon, F., Nicolet, Y., Masson, P., Kurkova, I., Smirnov, I., Friboulet, A., Tramontano, A., Gabibov, A. 1.36 X-RAY DIFFRACTION 0.19137 0.16172 False True IGHV4 IGLV1 Lambda 2.30e-06 -7.67 ITC 25 21896761 2bmk B A 0 IMMUNE SYSTEM 03/14/05 Fab fragment of PLP-dependent catalytic antibody 15A9 in complex with phosphopyridoxyl-D-alanine MUS MUSCULUS mus musculus mus musculus Pimpaneau, B.Golinelli-, Christen, P. 2.3 X-RAY DIFFRACTION 0.2725 0.2097 False True IGHV7 IGKV4 Kappa 2.4e-06 -7.666763597229133 Unknown TBD 3ngb J K 0 I protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/10 Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.68 X-RAY DIFFRACTION 0.256 0.197 False True IGHV1 IGKV3 Kappa 7.70e-09 -10.88 SPR 20 20616231 7kqy F NA 0 NA NA NA NA IMMUNE SYSTEM 11/18/20 Crystal Structure and Characterization of Human Heavy-Chain only Antibodies reveals a novel, stable dimeric structure similar to Monoclonal Antibodies HOMO SAPIENS homo sapiens Bahmanjah, S., Mieczkowski, C., Yu, Y., Baker, J., Raghunathan, G., Tomazela, D., Hsieh, M., Mccoy, M., Strickland, C., Fayadat-Dilman, L. 2.913 X-RAY DIFFRACTION 0.260 0.207 False True IGHV1 NA NA None None None None None 7f54 N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/21/21 Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Zhang, H., Chen, L., Mao, C., Shen, Q., Yang, D., Shen, D., Qin, J. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6al4 F E 0 IMMUNE SYSTEM 08/07/17 CRYSTAL STRUCTURE OF ANTI-CD19 ANTIBODY B43 FAB HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.45 X-RAY DIFFRACTION 0.236 0.206 False True IGHV1 IGKV1 Kappa None None None None None 6u50 C NA 0 IMMUNE SYSTEM 08/26/19 Anti-Sudan ebolavirus Nucleoprotein Single Domain Antibody Sudan B (SB) LAMA GLAMA lama glama Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 1.6 X-RAY DIFFRACTION 0.214 0.169 False True unknown unknown unknown None None None None None 7l8p H L 0 A protein NA isoform 3 of integrin alpha-iib CELL ADHESION 12/31/20 Integrin alphaIIbbeta3 in complex with sibrafiban HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lin, F.-Y., Springer, T.A. 2.34995 X-RAY DIFFRACTION 0.245 0.204 False True IGHV14 IGKV14 Kappa None None None None None 2htk E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/26/06 Structure of the Escherichia coli ClC chloride channel Y445A mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.41 X-RAY DIFFRACTION 0.276 0.266 False False IGHV4 IGKV4 Kappa None None None None None 5gs1 N M 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 False True IGHV3 IGKV3 Kappa None None None None None 7bnp A NA 0 NA NA NA NA IMMUNE SYSTEM 01/22/21 Llama nanobody nb17 raised against GldL from Flavobacterium jonhsoniae LAMA GLAMA lama glama Trinh, N.T., Cambillau, C., Leone, P. 1.7 X-RAY DIFFRACTION 0.226 0.213 False True IGHV1 NA NA None None None None None 7nrh H L 0 A protein NA envelope polyprotein VIRUS LIKE PARTICLE 03/03/21 Hantaan virus glycoprotein (Gn) in complex with Fab fragment HTN-Gn1. ORYCTOLAGUS CUNICULUS; HANTAAN ORTHOHANTAVIRUS oryctolagus cuniculus oryctolagus cuniculus hantaan orthohantavirus Stass, R., Rissanen, I., Bowden, T.A., Huiskonen, J.T. 19 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6k0y A B 0 C protein programmed cell death protein 1 IMMUNE SYSTEM 05/08/19 Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liu, J.X., Wang, G.Q. 1.7 X-RAY DIFFRACTION 0.214 0.171 False True IGHV4 IGKV1 Kappa None None None None None 7jie C D 0 B protein NA vp1 VIRAL PROTEIN 07/23/20 Structure of GII.4 P-domain in Complex with NORO-320 FAB NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; HOMO SAPIENS homo sapiens homo sapiens norovirus hu/gii.4/sydney/nsw0514/2012/au Salmen, W., Hu, L., Prasad, B. 2.254 X-RAY DIFFRACTION 0.225 0.181 False True IGHV1 IGKV2 Kappa None None None None None 5hdo A NA 0 IMMUNE SYSTEM 01/05/16 Crystal structure of a nanobody raised against urokinase-type plasminogen activator CAMELUS DROMEDARIUS camelus dromedarius Kromann-Hansen, T. 2.16 X-RAY DIFFRACTION 0.218 0.177 False True IGHV1 None None None None None 7p5y K NA 0 E protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3qeh A B 0 IMMUNE SYSTEM 01/20/11 Crystal structure of human N12-i15, an ADCC and non-neutralizing anti-HIV-1 Env antibody HOMO SAPIENS homo sapiens homo sapiens Guan, Y., DeVico, A.L., Lewis, G.K., Pazgier, M. 2.59 X-RAY DIFFRACTION 0.254 0.216 False False IGHV1 IGKV2 Kappa None None None None None 7s0b C D 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 RBD in complex with neutralizing antibody N-612-056 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tanaka, S., Barnes, C.O., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.260 0.215 False True IGHV3 IGKV1 Kappa None None None None None 7tfo P Q 0 C protein NA envelope glycoprotein bg505 sosip.664 - gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/06/22 Cryo-EM structure of HIV-1 Env trimer BG505 SOSIP.664 in complex with CD4bs antibody Ab1573 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6mw9 C D 0 B protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-3 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 3chn A L 6 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7dk6 c d 0 B protein NA the light chain of 2h2 fab VIRAL PROTEIN 11/23/20 S-2H2-F2 structure, two RBDs are up and one RBD is down, each up RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 4.3 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 1a4k H L 0 H Hapten FRA [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID IMMUNOGLOBULIN 01/30/98 DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE MUS MUSCULUS mus musculus mus musculus mus musculus Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C. 2.4 X-RAY DIFFRACTION 0.291 0.211 False True IGHV9 IGKV1 Kappa 1.00e-08 -10.91 Other 25 9506942 4k07 NA I 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 7n65 C D 0 A protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 06/07/21 Complex structure of HIV superinfection Fab QA013.2 and BG505.SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Mangala Prasad, V., Shipley, M.M., Overbaugh, J.M., Lee, K.K. 4.15 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 5mx3 A B 0 IMMUNE SYSTEM 01/20/17 Structure of DC8E8 Fab crystallized at pH 8.5 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.98 X-RAY DIFFRACTION 0.256 0.219 False False IGHV1 IGKV8 Kappa None None None None None 7mu4 H L 0 NA NA NA NA IMMUNE SYSTEM 05/14/21 Crystal Structure of HPV L1-directed D24.M01Fab HOMO SAPIENS homo sapiens homo sapiens Singh, S., Pancera, M. 1.83 X-RAY DIFFRACTION 0.211 0.174 False True IGHV2 IGLV1 Lambda None None None None None 7rai J N 0 E protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 07/01/21 Cryo-EM structure of M4008_N1 Fab in complex with BG505 DS-SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.P. 3.24 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7a17 D NA 0 C protein NA isoform 2 of synaptojanin-1 HYDROLASE 08/12/20 Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Paesmans, J., Galicia, C., Martin, E., Versees, W. 2.73 X-RAY DIFFRACTION 0.257 0.196 False True IGHV1 NA NA None None None None None 6gkd P NA 0 O protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 6o25 I J 0 L | C peptide | protein NA | NA circumsporozoite protein | anti-kappa vhh domain IMMUNE SYSTEM 02/22/19 Crystal structure of 3945 Fab in complex with circumsporozoite protein NANP3 and anti-Kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | lama glama Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.268 0.215 False True IGHV3 IGKV3 Kappa None None None None None 1lo3 Y X 0 Y Hapten AN1 3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID IMMUNE SYSTEM 05/06/02 Retro-Diels-Alderase Catalytic Antibody: Product Analogue MUS MUSCULUS mus musculus mus musculus mus musculus Hugot, M., Reymond, J.L., Baumann, U. 2.3 X-RAY DIFFRACTION 0.259 0.208 False False IGHV5 IGKV1 Kappa None None None None None 7vsw N M 0 NA NA NA NA BIOSYNTHETIC PROTEIN 10/27/21 Crystal structure of a Fab-like fragment of anti-mesothelin antibody HOMO SAPIENS homo sapiens homo sapiens Yang, Z., Ying, T. 3.0 X-RAY DIFFRACTION 0.253 0.217 False True IGHV4 IGKV1 Kappa None None None None None 4jlr H L 0 S protein rsv_1isea designed scaffold IMMUNE SYSTEM 03/12/13 Crystal structure of a designed Respiratory Syncytial Virus Immunogen in complex with Motavizumab Rupert, P.B., Correia, B., Schief, W., Strong, R.K. 2.71 X-RAY DIFFRACTION 0.249 0.191 False True IGHV2 IGKV1 Kappa 2.9899999999999995e-11 -14.357753376338442 SPR TBD 6phb D C 0 I protein 25 kda ookinete surface antigen IMMUNE SYSTEM 06/25/19 Pfs25 in complex with the human transmission blocking antibody 2530 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum McLeod, B.R., Julien, J.P. 2.0 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV1 Kappa None None None None None 3ejy C D 0 A protein h(+)/cl(-) exchange transporter clca IMMUNE SYSTEM/PROTON TRANSPORT 09/18/08 Structure of E203H mutant of E.coli Cl-/H+ antiporter, CLC-ec1 ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.2 X-RAY DIFFRACTION 0.279 0.244 False False IGHV4 IGKV4 Kappa None None None None None 6niy N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/02/19 A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens dal Maso, E., Glukhova, A., Zhu, Y., Garcia-Nafria, J., Tate, C.G., Atanasio, S., Reynolds, C.A., Ramirez-Aportela, E., Carazo, J.-M., Hick, C.A., Furness, S.G.B., Hay, D.L., Liang, Y.-L., Miller, L.J., Christopoulos, A., Wang, M.-W., Wootten, D., Sexton, P.M. 3.34 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6opo O K 0 J protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1tqb B C 0 A protein prion protein UNKNOWN FUNCTION/IMMUNE SYSTEM 06/17/04 Ovine recombinant PrP(114-234), VRQ variant in complex with the Fab of the VRQ14 antibody OVIS ARIES; MUS MUSCULUS mus musculus mus musculus ovis aries Eghiaian, F., Grosclaude, J., Debey, P., Doublet, B., Treguer, E., Rezaei, H., Knossow, M. 2.55 X-RAY DIFFRACTION 0.268 0.214 False True IGHV9 IGKV1 Kappa None None None None None 4tqe H L 0 A peptide microtubule-associated protein tau IMMUNE SYSTEM 06/11/14 Structure of tau peptide in complex with Tau5 antibody Fab fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Cehlar, O., Skrabana, R., Novak, M. 1.6 X-RAY DIFFRACTION 0.197 0.151 False False IGHV14 IGKV1 Kappa None None None None None 4yhn F L 0 IMMUNE SYSTEM 02/27/15 Dabigatran Reversal Agent HOMO SAPIENS homo sapiens homo sapiens Schiele, F., Nar, H. 2.31 X-RAY DIFFRACTION 0.220 0.182 False True IGHV1 IGKV1 Kappa None None None None None 2j4w H L 0 D peptide apical membrane antigen 1 IMMUNE SYSTEM 09/07/06 Structure of a Plasmodium vivax apical membrane antigen 1-Fab F8.12. 18 complex PLASMODIUM VIVAX; MUS MUSCULUS mus musculus mus musculus plasmodium vivax Igonet, S., Vulliez-Le Normand, B., Faure, G., Riottot, M.M., Kocken, C.H.M., Thomas, A.W., Bentley, G.A. 2.5 X-RAY DIFFRACTION 0.241 0.187 False False IGHV5 IGKV4 Kappa 6.00e-10 -12.57 SPR 17229439 4hc1 H L 0 A protein mucosal addressin cell adhesion molecule 1 IMMUNE SYSTEM 09/28/12 Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Springer, T., Yu, Y., Zhu, J. 2.871 X-RAY DIFFRACTION 0.253 0.200 False True IGHV3 IGKV14 Kappa None None None None None 6m0f H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 02/21/20 X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) in substrate-free form DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Shabareesh, P., Mallela, A.K., Joseph, D., Penmatsa, A. 3.3 X-RAY DIFFRACTION 0.277 0.241 False True IGHV5 IGKV4 Kappa None None None None None 6wgj C D 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.9 X-RAY DIFFRACTION 0.289 0.235 False True IGHV3 IGKV2 Kappa None None None None None 5utz H L 0 D protein interleukin-2 CYTOKINE/IMMUNE SYSTEM 02/15/17 Human IL-2/Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Jude, K.M., Garcia, K.C. 2.747 X-RAY DIFFRACTION 0.248 0.193 False True IGHV4 IGLV6 Lambda 1.879e-09 -11.904493814008964 SPR TBD 2q8b H L 0 A protein apical membrane antigen 1 Immune System 06/10/07 Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Gupta, A., Murphy, V.J., Anders, R.F., Batchelor, A.H. 2.3 X-RAY DIFFRACTION 0.256 0.209 False False IGHV14 IGKV6 Kappa None None None None None 5o05 C NA 0 B protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 norovirus protruding domain in complex with Nanobody Nano-42 VICUGNA PACOS; NORWALK VIRUS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, G.S. 2.0 X-RAY DIFFRACTION 0.222 0.180 False True IGHV1 8.100000000000001e-10 -12.403045576779583 ITC TBD 7a4y A NA 0 NA NA NA NA DE NOVO PROTEIN 08/20/20 Crystal structure of the P5P6 coiled-coil in complex with nanobody Nb34. LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama Hadzi, S. 2.157 X-RAY DIFFRACTION 0.229 0.196 False True IGHV3 NA NA None None None None None 6x98 H L 0 A protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11B fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6ehy A a 0 IMMUNE SYSTEM 09/15/17 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery HOMO SAPIENS homo sapiens Hargreaves, D. 2.25 X-RAY DIFFRACTION 0.285 0.228 True True unknown unknown unknown None None None None None 2qtj A L 6 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5k59 E F 0 B protein uncharacterized leukocidin-like protein 1 IMMUNE SYSTEM 05/23/16 Crystal structure of LukGH from Staphylococcus aureus in complex with a neutralising antibody STAPHYLOCOCCUS AUREUS (STRAIN USA300); HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus (strain usa300) WELIN, M., LOGAN, D.T., BADARAU, A., MIRKINA, I., ZAUNER, G., DOLEZILKOVA, I., NAGY, E. 2.84 X-RAY DIFFRACTION 0.237 0.197 False True IGHV4 IGKV1 Kappa 2.5e-12 -15.82804176815236 SPR TBD 7mfa Q R 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA+P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.286 0.238 False True IGHV3 IGLV3 Lambda None None None None None 6y54 H L 0 L unknown OAB unknown IMMUNE SYSTEM 02/24/20 Crystal structure of a Neisseria meningitidis serogroup A capsular oligosaccharide bound to a functional Fab MUS MUSCULUS mus musculus mus musculus mus musculus Dello Iacono, L., Henriques, P., Adamo, R. 2.67 X-RAY DIFFRACTION 0.267 0.210 False True IGHV1 IGKV1 Kappa None None None None None 5ywf D C 0 IMMUNE SYSTEM 11/29/17 Crystal structure of 2H4 Fab MUS MUSCULUS mus musculus mus musculus Qiu, X., Lei, Y., Yang, P., Gao, Q., Wang, N., Cao, L., Wang, X., Xu, Z.K., Rao, Z. 2.206 X-RAY DIFFRACTION 0.262 0.216 False False IGHV9 IGKV3 Kappa None None None None None 3ulv D C 0 A protein toll-like receptor 3 IMMUNE SYSTEM 11/11/11 Structure of quaternary complex of human TLR3ecd with three Fabs (Form2) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 3.522 X-RAY DIFFRACTION 0.253 0.231 False True IGHV6 IGLV3 Lambda None None None None None 6sc8 C NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-Ligand4 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.106 X-RAY DIFFRACTION 0.261 0.219 False True IGHV3 None None None None None 2kh2 B b 15 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 4zg1 E NA 0 PROTEIN BINDING 04/22/15 Crystal structure of a nanobody raised against KDM5b LAMA GLAMA lama glama Wiuf, A., Kristensen, O., Gajhede, M. 1.85 X-RAY DIFFRACTION 0.235 0.186 False True IGHV1 None None None None None 7ej5 I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/01/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7jie E F 0 A protein NA vp1 VIRAL PROTEIN 07/23/20 Structure of GII.4 P-domain in Complex with NORO-320 FAB NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; HOMO SAPIENS homo sapiens homo sapiens norovirus hu/gii.4/sydney/nsw0514/2012/au Salmen, W., Hu, L., Prasad, B. 2.254 X-RAY DIFFRACTION 0.225 0.181 False True IGHV1 IGKV2 Kappa None None None None None 5x2m H L 0 A protein NA taste receptor, type 1, member 2a SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-glutamine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.206 X-RAY DIFFRACTION 0.227 0.173 False True IGHV1 IGKV3 Kappa None None None None None 7czs J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B8_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6a76 H L 0 IMMUNE SYSTEM 07/02/18 Crystal structure of the Fab fragment of B5209B, a murine monoclonal antibody specific for the fifth immunoglobulin domain (Ig5) of human ROBO1 MUS MUSCULUS mus musculus mus musculus Mizohata, E., Nakayama, T., Kado, Y., Inoue, T. 1.5 X-RAY DIFFRACTION 0.165 0.129 False True IGHV5 IGKV12 Kappa None None None None None 3lrg NA A 0 IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain HOMO SAPIENS homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.05 X-RAY DIFFRACTION 0.197 0.170 False True IGLV1 Lambda None None None None None 4fqh A B 0 IMMUNE SYSTEM 06/25/12 Crystal Structure of Fab CR9114 HOMO SAPIENS homo sapiens homo sapiens Dreyfus, C., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGLV1 Lambda None None None None None 3g6j F E 0 B | A protein | protein NA | NA complement c3 alpha chain | complement c3 beta chain IMMUNE SYSTEM 02/06/09 C3b in complex with a C3b specific Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Wiesmann, C. 3.1 X-RAY DIFFRACTION 0.282 0.214 False True IGHV3 IGKV1 Kappa 1.90e-09 -11.89 SPR 25 19196712 4f9p C c 0 A protein butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 05/19/12 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 103.2 Single Chain Antibody HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Palakodeti, A., Sandstrom, A., Sundaresan, L., Harly, C., Nedellec, S., Olive, D., Scotet, E., Bonneville, M., Adams, E.J. 3.519 X-RAY DIFFRACTION 0.408 0.373 True True unknown unknown unknown 1.5000000000000002e-08 -10.67372125591851 SPR TBD 5g5r B NA 0 A protein site-2 protease HYDROLASE 06/02/16 CBS domain tandem of site-2 protease from Archaeoglobus fulgidus in complex with llama Nanobody - apo form LAMA GLAMA; ARCHAEOGLOBUS FULGIDUS lama glama archaeoglobus fulgidus Schacherl, M., Baumann, U. 2.4 X-RAY DIFFRACTION 0.250 0.207 False True IGHV1 None None None None None 3hi1 H L 0 G protein glycoprotein 120 STRUCTURAL PROTEIN/Immune System 05/18/09 Structure of HIV-1 gp120 (core with V3) in Complex with CD4-Binding-Site Antibody F105 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 Kwon, Y.D., Chen, L., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z., Zhang, M.-Y., Arthos, J., Burton, D.R., Dimitrov, D., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.243 0.202 False False IGHV4 IGKV3 Kappa 1.12e-08 -10.84 SPR 19965434 7e5y C B 0 A protein NA spike protein s1 VIRAL PROTEIN 02/21/21 Molecular basis for neutralizing antibody 2B11 targeting SARS-CoV-2 RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wu, H., Yu, F., Wang, Q.S., Zhou, H., Wang, W.W., Zhao, T., Pan, Y.B., Yang, X.M. 3.59 X-RAY DIFFRACTION 0.277 0.232 False True IGHV3 IGLV1 Lambda None None None None None 3g5z B A 0 IMMUNE SYSTEM 02/05/09 Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR MUS MUSCULUS mus musculus mus musculus Garrett, T.P.J., Burgess, A.W. 2.6 X-RAY DIFFRACTION 0.301 0.214 False True IGHV3 IGKV14 Kappa None None None None None 7rdk B A 0 NA NA NA NA IMMUNE SYSTEM 07/09/21 Crystal structure of PCDN-16B, an anti-HIV antibody from the PCDN bnAb lineage (cysteinylated state) HOMO SAPIENS homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 2.46 X-RAY DIFFRACTION 0.253 0.208 False True IGHV4 IGKV3 Kappa None None None None None 7phu B C 0 A protein NA reticulocyte-binding protein homolog 5 IMMUNE SYSTEM 08/18/21 PfRH5 bound to monoclonal antibody R5.015 and R5.016 Fab fragments PLASMODIUM FALCIPARUM (ISOLATE 3D7); HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 2.53 X-RAY DIFFRACTION 0.276 0.236 False True IGHV1 IGLV3 Lambda None None None None None 7vne W NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 10/10/21 Structure of the SARS-CoV-2 spike glycoprotein in complex with a human single domain antibody n3113.1 (UUU-state) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Yang, Z., Wang, Y., Kong, Y., Jin, Y., Wu, Y., Ying, T. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4ios D NA 0 H protein NA bpp VIRAL PROTEIN 01/08/13 Structure of phage TP901-1 RBP (ORF49) in complex with nanobody 11. LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 Desmyter, A., Farenc, C., Mahony, J., Spinelli, S., Bebeacua, C., Blangy, S., Veesler, D., van Sinderen, D., Cambillau, C. 2.4 X-RAY DIFFRACTION 0.227 0.201 False True IGHV1 NA NA None None None None None 2xqy J K 0 E protein envelope glycoprotein h IMMUNE SYSTEM/VIRAL PROTEIN 09/08/10 Crystal structure of Pseudorabies core fragment of glycoprotein H in complex with Fab d6.3 SUID HERPESVIRUS; MUS MUSCULUS mus musculus mus musculus suid herpesvirus Backovic, M., Dubois, R., Cockburn, J., Sharff, A., Vaney, M., Granzow, H., Klupp, B., Bricogne, G., Mettenleiter, T., Rey, F. 2.05 X-RAY DIFFRACTION 0.2046 0.1878 False True IGHV1 IGKV3 Kappa None None None None None 5v8l H L 0 A protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/22/17 BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7eh3 A NA 1 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 4r7d K L 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 5vh4 A B 0 IMMUNE SYSTEM 04/12/17 Crystal structure of Fab fragment of anti-TNFa antibody infliximab in an I-centered orthorhombic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Mayclin, S.J., Edwards, T.E., Lerch, T.F., Conlan, H., Sharpe, P. 2.0 X-RAY DIFFRACTION 0.187 0.158 False True IGHV6 IGKV5 Kappa None None None None None 6mu7 H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/22/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-818251 in Complex with Human Antibodies 3H109L and 35O22 at 3.1 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.501 X-RAY DIFFRACTION 0.261 0.223 False True IGHV4 unknown unknown None None None None None 1mcd NA B 0 P peptide peptide n-acetyl-d-phe-b-ala-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 6vl8 A B 0 E Hapten PEU 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL IMMUNE SYSTEM 01/23/20 Anti-PEG antibody 6-3 Fab fragment in complex with PEG MUS MUSCULUS mus musculus mus musculus mus musculus Nicely, N.I., Huckaby, J.T., Lai, S.K., Jacobs, T.M. 2.42 X-RAY DIFFRACTION 0.240 0.185 False True IGHV9 IGKV8 Kappa None None None None None 4xpb H L 0 tranport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus Aravind, P., Wang, K., Gouaux, E. 3.05 X-RAY DIFFRACTION 0.269 0.244 False True IGHV5 IGKV4 Kappa None None None None None 5sx4 J I 0 M protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 08/09/16 Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sickmier, E.A., Kurzeja, R.J.M., Michelsen, K., Mukta, V., Yang, E., Tasker, A.S. 2.8 X-RAY DIFFRACTION 0.266 0.223 False True IGHV4 IGKV1 Kappa 3.4000000000000007e-10 -12.917373922881485 SPR TBD 7zf5 G I 0 A protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-12 and Beta-54 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 5.32 X-RAY DIFFRACTION 0.256 0.249 False True IGHV1 IGKV3 Kappa None None None None None 7t62 B b 0 NA NA NA NA IMMUNE SYSTEM 12/13/21 GPC2 HEP CT3 complex HOMO SAPIENS; MUS MUSCULUS mus musculus Zhu, J., Cachau, R., De Val Alda, N., Li, N., Ho, M. 21 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3ldb C B 0 A protein bifunctional arginine demethylase and lysyl-hydroxylasejmjd6 IMMUNE SYSTEM 01/12/10 Structure of JMJD6 complexd with ALPHA-KETOGLUTARATE and Fab Fragment. HOMO SAPIENS; CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius homo sapiens Hong, X., Zang, J., White, J., Kappler, J.W., Wang, C., Zhang, G. 2.7 X-RAY DIFFRACTION 0.285 0.250 False True IGHV3 IGKV8 Kappa None None None None None 5n88 H NA 0 E protein pc4 and sfrs1-interacting protein IMMUNE SYSTEM 02/23/17 Crystal structure of antibody bound to viral protein HOMO SAPIENS homo sapiens homo sapiens Bao, L., Hannon, C., Cruz-Migoni, A., Ptchelkine, D., Sun, M.-y., Derveni, M., Bunjobpol, W., Chambers, J.S., Simmons, A., Phillips, S.E.V., Rabbitts, T.H. 1.7 X-RAY DIFFRACTION 0.252 0.188 False True IGHV3 1.0129999999999999e-06 -8.177811883783894 SPR TBD 5f7y C NA 0 A protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group A type-1 hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.44 X-RAY DIFFRACTION 0.205 0.176 False True IGHV1 None None None None None 3qxv C NA 0 C Hapten MTX METHOTREXATE IMMUNE SYSTEM 03/02/11 Structure of an Anti-Methotrexate CDR1-4 Graft VHH Antibody in Complex with Methotrexate LAMA GLAMA lama glama lama glama Fanning, S.W., Horn, J.R. 2.5 X-RAY DIFFRACTION 0.279 0.230 False True IGHV1 4e-09 -11.456840020052727 Unknown TBD 4cdg C NA 0 A protein bloom syndrome protein 10/31/13 Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Newman, J.A., Savitsky, P., Allerston, C.K., Pike, A.C.W., Pardon, E., Steyaert, J., Arrowsmith, C.H., Von Delft, F., Bountra, C., Edwards, A., Gileadi, O. 2.794 X-RAY DIFFRACTION 0.2455 0.2056 False True IGHV1 None None None None None 6oyz E NA 0 A protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to capuramycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.62 X-RAY DIFFRACTION 0.301 0.277 False True IGHV1 None None None None None 7d4b B NA 0 A protein NA tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 09/23/20 Crystal structure of 4-1BB in complex with a VHH HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Wang, C. 3.14 X-RAY DIFFRACTION 0.258 0.211 False True IGHV1 NA NA None None None None None 5dfv E F 0 B protein cd81 antigen IMMUNE SYSTEM 08/27/15 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH MURINE FAB FRAGMENT K04 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Harris, S.F., Wong, A., Kuglstatter, A. 2.8 X-RAY DIFFRACTION 0.291 0.239 False False IGHV1 IGKV3 Kappa 5e-10 -12.68887519701207 SPR TBD 4tyu B NA 0 IMMUNE SYSTEM 07/09/14 Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) LAMA GLAMA lama glama Legler, P.M. 2.13 X-RAY DIFFRACTION 0.263 0.239 False True IGHV1 None None None None None 7s8o E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/18/21 CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 ESCHERICHIA COLI; HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Cao, C., Fay, J.F., Gumpper, R.H., Roth, B.L. 2.58 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3w9d A B 0 IMMUNE SYSTEM 04/03/13 Structure of Human Monoclonal Antibody E317 Fab HOMO SAPIENS homo sapiens homo sapiens Lee, C.C., Lin, L.L., Wang, A.H.J. 2.32 X-RAY DIFFRACTION 0.259 0.190 False True IGHV1 IGKV3 Kappa None None None None None 7v61 H K 0 B protein NA angiotensin-converting enzyme 2 MEMBRANE PROTEIN 08/18/21 ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker Homo sapiens; Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus2 severe acute respiratory syndrome coronavirus2 homo sapiens Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 5ken C D 0 B protein ebola surface glycoprotein, gp2 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76); ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV1 IGKV12 Kappa None None None None None 6tnp K J 0 NA NA NA NA IMMUNE SYSTEM 12/09/19 Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide MUS MUSCULUS mus musculus mus musculus Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. 3.0 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV8 Kappa None None None None None 7st8 H L 0 S peptide NA astacin-like metalloendopeptidase IMMUNE SYSTEM 11/12/21 Crystal structure of 7H2.2 Fab in complex with SAS1B C-terminal region MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Legg, M.S.G., Evans, S.V. 2.75 X-RAY DIFFRACTION 0.270 0.231 False True IGHV8 IGKV3 Kappa None None None None None 4o4y H L 0 A peptide ides hinge peptide IMMUNE SYSTEM 12/19/13 Crystal structure of the anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide ORYCTOLAGUS CUNICULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens homo sapiens Malia, T.J., Teplyakov, A., Luo, J., Gilliland, G.L. 1.85 X-RAY DIFFRACTION 0.237 0.192 False True IGHV1 IGKV1 Kappa 1.55e-08 -10.654293821025798 Unknown TBD 4hjg B A 0 H | E protein | protein NA | NA immunoglobulin g-binding protein a | protein l fragment immune system 10/12/12 Meditope-enabled trastuzumab HOMO SAPIENS; STAPHYLOCOCCUS AUREUS; FINEGOLDIA MAGNA homo sapiens homo sapiens staphylococcus aureus | finegoldia magna Donaldson, J.M., Zer, C., Avery, K.N., Bzymek, K.P., Horne, D.A., Williams, J.C. 2.0 X-RAY DIFFRACTION 0.195 0.153 False True IGHV3 IGKV1 Kappa None None None None None 4w2q E NA 0 F protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS lama glama lake victoria marburgvirus Taylor, A.B., Garza, J.A. 2.7 X-RAY DIFFRACTION 0.274 0.220 False True IGHV1 None None None None None 7eh3 A NA 7 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 5aam B b 0 J protein envelope protein 07/27/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency MUS MUSCULUS; DENGUE VIRUS mus musculus dengue virus Wong, Y.H., Robinson, L.N., Lescar, J., Sasisekharan, R. 2.49 X-RAY DIFFRACTION 0.2698 0.2196 True True unknown unknown unknown 3.8e-09 -11.487230459870787 SPR TBD 4xnq H L 0 C protein influenza h5 ha head domain vietnam rdt mutations Viral protein/Immune system 01/15/15 Antibody hemagglutinin Complexes INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Spiller, B.W., Winarski, K.L. 2.001 X-RAY DIFFRACTION 0.225 0.191 False True IGHV4 IGLV3 Lambda None None None None None 3ubx G I 0 D protein antigen-presenting glycoprotein cd1d1 IMMUNE SYSTEM 10/25/11 Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex MUS MUSCULUS mus musculus mus musculus mus musculus Yu, E.D., Zajonc, D.M. 3.1 X-RAY DIFFRACTION 0.230 0.202 False False IGHV9 IGKV13 Kappa 2.52e-08 -10.366344400034732 Unknown TBD 6my4 H L 0 IMMUNE SYSTEM 11/01/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M,LC-S30bR] HOMO SAPIENS homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M. 1.69 X-RAY DIFFRACTION 0.230 0.189 False True IGHV3 IGKV1 Kappa None None None None None 2bx5 NA M 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 7a4d H NA 0 L peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 6ukt C NA 0 A protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 10/05/19 Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., Zhang, K., Johnston, J.D., Chiu, W., Sprang, S.R. 3.87 ELECTRON MICROSCOPY False True IGHV1 None None None None None 5nml J NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 4dvb A B 0 IMMUNE SYSTEM 02/23/12 The crystal structure of the Fab fragment of pro-uPA antibody mAb-112 MUS MUSCULUS mus musculus mus musculus Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M. 1.93 X-RAY DIFFRACTION 0.259 0.223 False False IGHV5 IGKV4 Kappa None None None None None 5t5n G F 0 E protein bestrophin-1 (best1) MEMBRANE PROTEIN 08/31/16 Calcium-activated chloride channel bestrophin-1 (BEST1), triple mutant: I76A, F80A, F84A; in complex with an Fab antibody fragment, chloride, and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Long, S.B., Vaisey, G. 3.1 X-RAY DIFFRACTION 0.243 0.218 False False IGHV1 IGKV12 Kappa None None None None None 5mp3 A B 0 C peptide microtubule-associated protein IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.75 X-RAY DIFFRACTION 0.250 0.199 False False IGHV1 IGKV8 Kappa None None None None None 4fq2 H L 0 IMMUNE SYSTEM 06/24/12 Crystal Structure of 10-1074 Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 1.9 X-RAY DIFFRACTION 0.223 0.187 False True IGHV4 unknown unknown None None None None None 7lq7 y z 0 E protein NA spike protein s1 IMMUNE SYSTEM 02/13/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.233 0.197 False False IGHV1 IGKV1 Kappa None None None None None 5t1k D C 0 IMMUNE SYSTEM 08/19/16 Cetuximab Fab in complex with CQFDA(Ph)2STRRLKC MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.213 0.160 False True IGHV2 IGKV5 Kappa 5.3e-07 -8.561619551666432 Unknown TBD 5t3s H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 08/26/16 HIV gp140 trimer MD39-10MUTA in complex with Fabs PGT124 and 35022 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Stanfield, R.L., Wilson, I.A. 4.5 X-RAY DIFFRACTION 0.309 0.270 False True IGHV4 unknown unknown None None None None None 7x7o J K 0 D protein NA spike protein s1 VIRAL PROTEIN 03/10/22 SARS-CoV-2 spike RBD in complex with neutralizing antibody UT28K SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozawa, T., Tani, H., Anraku, Y., Kita, S., Igarashi, E., Saga, Y., Inasaki, N., Kawasuji, H., Yamada, H., Sasaki, S., Somekawa, M., Sasaki, J., Hayakawa, Y., Yamamoto, Y., Morinaga, Y., Kurosawa, N., Isobe, M., Fukuhara, H., Maenaka, K., Hashiguchi, T., Kishi, H., Kitajima, I., Saito, S., Niimi, H. 3.75 X-RAY DIFFRACTION 0.336 0.303 False True IGHV1 IGKV3 Kappa None None None None None 6db7 H L 0 P peptide hiv-1 gp120 v3 peptide from mn strain IMMUNE SYSTEM 05/02/18 Crystal structure of anti-HIV-1 V3 Fab 1334 in complex with a HIV-1 gp120 V3 peptide from MN strain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.-P. 2.213 X-RAY DIFFRACTION 0.260 0.213 False True IGHV1 IGLV3 Lambda None None None None None 7mhy O P 0 A protein NA protein-cysteine n-palmitoyltransferase hhat TRANSFERASE/IMMUNE SYSTEM 04/16/21 Human Hedgehog acyltransferase (HHAT) in complex with palmitoyl-CoA and two Fab antibody fragments HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Long, S.B., Jiang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV9 IGKV1 Kappa None None None None None 7tyo N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/14/22 Calcitonin receptor in complex with Gs and human calcitonin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7t3d P R 0 I protein NA hemagglutinin ha2 chain Viral Protein/IMMUNE SYSTEM 12/07/21 CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA INFLUENZA A VIRUS (A/CALIFORNIA/04/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009(h1n1)) Han, J., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5m30 F NA 0 C protein type vi secretion protein SECRETION SYSTEM 10/13/16 Structure of TssK from T6SS EAEC in complex with nanobody nb18 VICUGNA PACOS; ESCHERICHIA COLI vicugna pacos escherichia coli Nguyen, V.S., Cambillau, C., Spinelli, C., Desmyter, A., Legrand, P., Cascales, E. 2.6 X-RAY DIFFRACTION 0.226 0.207 False True IGHV1 None None None None None 6ocd D NA 0 C protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V6D4 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 2.103 X-RAY DIFFRACTION 0.228 0.189 False True IGHV1 None None None None None 6rbb I NA 0 IMMUNE SYSTEM 05/13/20 CRYSTAL STRUCTURE OF the VhH-domain of anti-IL-17A antibody netakimab LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 2.45 X-RAY DIFFRACTION 0.280 0.216 False True IGHV1 None None None None None 6opp H L 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 Asymmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6n7j A B 0 D peptide envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/27/18 BDBV223 Fab bound to synthetic peptide of Bundibugyo virus Glycoprotein Stalk HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens bundibugyo ebolavirus King, L.B., West, B.R., Saphire, E.O. 3.684 X-RAY DIFFRACTION 0.254 0.228 False True IGHV4 IGKV3 Kappa None None None None None 3qrg H L 0 IMMUNE SYSTEM 02/17/11 Crystal structure of antiRSVF Fab B21m HOMO SAPIENS homo sapiens homo sapiens Luo, J., Tsui, P., Lewandowski, F., Spurlino, J., Vecchio, F.D. 1.699 X-RAY DIFFRACTION 0.185 0.161 False True IGHV2 IGKV4 Kappa None None None None None 7l7e E F 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV3 IGKV4 Kappa None None None None None 7lmo NA A 0 B Hapten NYO (5~{R})-3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-7-(1~{H}-imidazol-4-ylcarbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 34 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-7-(1H-imidazole-5-carbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.99 X-RAY DIFFRACTION 0.225 0.176 False True NA IGLV6 Lambda None None None None None 7ej4 I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/01/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-25 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 1svz a A 0 C peptide epitope peptide corresponding to n-terminus ofhiv-2 protease IMMUNE SYSTEM 03/30/04 Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus Rezacova, P., Brynda, J., Lescar, J., Bentley, G.A., Fabry, M., Horejsi, M., Sedlacek, J. 1.89 X-RAY DIFFRACTION 0.239 0.196 True True unknown unknown unknown None None None None None 4zxb C D 0 E protein insulin receptor HORMONE RECEPTOR/IMMUNE SYSTEM 05/20/15 Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Croll, T., Smith, B.J., Margetts, M.B., Whittaker, J., Weiss, M.A., Ward, C.W., Lawrence, M.C. 3.3 X-RAY DIFFRACTION 0.237 0.205 False True IGHV1 IGKV9 Kappa None None None None None 5u5f B A 0 C | E protein | protein NA | NA immunoglobulin g binding protein a | protein l IMMUNE SYSTEM 12/06/16 MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT IN COMPLEX WITH (Ac) CQFDA(PH)2STRRLRCGGSK HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens staphylococcus aureus | finegoldia magna Bzymek, K.P., Avery, K.N., Zer, C., Williams, J.C. 1.81 X-RAY DIFFRACTION 0.192 0.163 False True IGHV3 IGKV1 Kappa None None None None None 1mj7 H L 0 H Hapten HAL N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE IMMUNE SYSTEM 08/27/02 Crystal Structure Of The Complex Of The Fab fragment of Esterolytic Antibody MS5-393 and A Transition-State Analog MUS MUSCULUS mus musculus mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 2.25 X-RAY DIFFRACTION 0.303 0.200 False True IGHV1 IGKV2 Kappa 4.500000000000001e-09 -11.38705549364546 Unknown TBD 7np1 K O 0 D protein NA spike protein s1 VIRAL PROTEIN 02/26/21 Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hall, G., Cowan, R., Carr, M. 2.8 X-RAY DIFFRACTION 0.281 0.232 False True IGHV3 IGKV1 Kappa None None None None None 5vk2 F G 0 b | B protein | protein NA | NA unknown | pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/Immune system 04/20/17 Structural basis for antibody-mediated neutralization of Lassa virus LASSA VIRUS; LASSA VIRUS (STRAIN MOUSE/SIERRA LEONE/JOSIAH/1976); HOMO SAPIENS homo sapiens homo sapiens lassa virus (strain mouse/sierraleone/josiah/1976) | lassa virus Hastie, K.M., Zandonatti, M.A., Kleinfelter, L.M., Rowland, M.L., Rowland, M.M., Chandra, K., Branco, L.M., Robinson, J.E., Garry, R.F., Saphire, E.O. 3.201 X-RAY DIFFRACTION 0.231 0.189 False True IGHV3 IGLV2 Lambda None None None None None 6xsk H L 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral Protein 07/15/20 Cryo-EM structure of vaccine-elicited Rhesus VH6-1 antibody 789-203-3C12 in complex with stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer MACACA MULATTA; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) macaca mulatta macaca mulatta influenza a virus (a/solomonislands/3/2006(h1n1)) | influenza a virus (a/solomonislands/3/2006(h1n1)) Cerutti, G., Gorman, J., Kwong, P.D., Shapiro, L. 3.85 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 6p3s P Q 0 R protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 4m7j H L 0 H carbohydrate KDA polysaccharide IMMUNE SYSTEM 08/12/13 Crystal structure of S25-26 in complex with Kdo(2.8)Kdo(2.4)Kdo trisaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V., Muller-Loennies, S., Saldova, R., Muniyappa, M., Brade, L., Rudd, P.M., Harvey, D.J., Kosma, P., Brade, H. 1.95 X-RAY DIFFRACTION 0.247 0.212 False False IGHV2 IGKV1 Kappa 7.81e-07 -8.33191472899872 Unknown TBD 2ltq C B 3 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 6vep I J 0 K protein insulin receptor subunit alpha HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM 06/03/20 Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G.T. 2.9 X-RAY DIFFRACTION 0.225 0.193 False True IGHV2 IGKV8 Kappa None None None None None 5fec A B 0 D protein 426c.tm4deltav1-3 gp120 IMMUNE SYSTEM 12/16/15 Crystal structure of 3BNC60 Fab germline precursor in complex with 426c.TM4deltaV1-3 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Bjorkman, P.J. 3.17 X-RAY DIFFRACTION 0.266 0.202 False True IGHV1 IGKV1 Kappa None None None None None 7rly A B 0 Q peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide DRAAGQPAGDRADGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.67 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 IGKV1 Kappa None None None None None 1s5h B A 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 01/20/04 Potassium Channel Kcsa-Fab Complex T75C mutant in K+ STREPTOMYCES COELICOLOR, STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces coelicolor, streptomyces lividans Mackinnon, R., Zhou, M. 2.2 X-RAY DIFFRACTION 0.240 0.222 False False IGHV1 IGKV5 Kappa None None None None None 6q23 J K 0 B protein neuraminidase VIRAL PROTEIN,HYDROLASE/IMMUNE SYSTEM 08/06/19 Crystal structure of human 1G01 Fab in complex with influenza virus neuraminidase from A/California/04/2009 (H1N1) INFLUENZA A VIRUS (A/CALIFORNIA/04/2009 (H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009 (h1n1) Zhu, X., Wilson, I.A. 3.27 X-RAY DIFFRACTION 0.241 0.196 False True IGHV3 IGKV1 Kappa None None None None None 3zks D NA 0 A protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 01/24/13 BACE2 XAPERONE COMPLEX WITH INHIBITOR HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 2.11 X-RAY DIFFRACTION 0.26041 0.20850 False True IGHV3 None None None None None 3ifp A B 0 Q peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 2.95 X-RAY DIFFRACTION 0.269 0.235 False True IGHV8 IGKV1 Kappa 2.45e-08 -10.38 SPR 25 19923222 3j2z D C 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m10 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 3kym H G 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 6wju B A 0 NA NA NA NA IMMUNE SYSTEM 04/14/20 Fab Fragment of Anti-human LAG3 antibody (4A10) MUS MUSCULUS mus musculus mus musculus Agnihotri, P., Mishra, A.K., Mariuzza, R.A. 3.1 X-RAY DIFFRACTION 0.287 0.228 False True IGHV14 IGKV2 Kappa None None None None None 6azm D C 0 F peptide circumsporozoite protein nanp 5-mer IMMUNE SYSTEM 09/11/17 Crystal structure of the 580 germline antibody bound to circumsporozoite protein NANP 5-mer HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 1.6 X-RAY DIFFRACTION 0.199 0.166 False True IGHV3 IGKV4 Kappa None None None None None 7mem I K 0 F protein NA hemagglutinin ha1 chain Viral protein/IMMUNE SYSTEM 04/06/21 CryoEM structure of monoclonal Fab 045-09 2B05 binding the lateral patch of influenza virus H1 HA INFLUENZA A VIRUS (STRAIN SWL A/CALIFORNIA/04/2009 H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain swla/california/04/2009 h1n1) Han, J., Ward, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3iyw K M 0 C protein polyprotein VIRUS 06/18/10 West Nile virus in complex with Fab fragments of MAb CR4354 (fitted coordinates of envelope proteins and Fab fragments of one icosahedral ASU) WEST NILE VIRUS; HOMO SAPIENS homo sapiens homo sapiens west nile virus Rossmann, M.G., Kaufmann, B. 13.7 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 7f9y N NA 0 A | B | G protein | protein | protein NA | NA | NA engineered g-alpha-q subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 07/05/21 ghrelin-bound ghrelin receptor in complex with Gq HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens | homo sapiens Wang, Y., Zhuang, Y., Xu, P., Xu, H.E., Jiang, Y. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5ds8 H L 0 P peptide tetrapeptide gly-hpu-gly-ala IMMUNE SYSTEM 09/17/15 Context-independent anti-hypusine antibody FabHpu98 in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Zhai, Q., Carter, P.J. 1.95 X-RAY DIFFRACTION 0.224 0.183 False True IGHV1 IGKV1 Kappa None None None None None 6rps N M 0 B protein carbonic anhydrase 12 LYASE 05/14/19 X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Alterio, V., Esposito, D., De Simone, G. 2.79 X-RAY DIFFRACTION 0.231 0.203 False True IGHV2 IGKV5 Kappa None None None None None 4dvb H L 0 IMMUNE SYSTEM 02/23/12 The crystal structure of the Fab fragment of pro-uPA antibody mAb-112 MUS MUSCULUS mus musculus mus musculus Jiang, L., Botkjaer, K.A., Andersen, L.M., Yuan, C., Andreasen, P.A., Huang, M. 1.93 X-RAY DIFFRACTION 0.259 0.223 False False IGHV5 IGKV4 Kappa None None None None None 5e7f A NA 0 G protein major structural protein 1 VIRAL PROTEIN 10/12/15 Complex between lactococcal phage Tuc2009 RBP head domain and a nanobody (L06) CAMELUS DROMEDARIUS; LACTOCOCCUS PHAGE TUC2009 camelus dromedarius lactococcus phage tuc2009 Legrand, P., Collins, B., Blangy, S., Murphy, J., Spinelli, S., Gutierrez, C., Richet, N., Kellenberger, C., Desmyter, A., Mahony, J., van Sinderen, D., Cambillau, C. 2.7 X-RAY DIFFRACTION 0.208 0.194 False True IGHV1 9.1e-09 -10.969830253718456 SPR TBD 6zrv B NA 0 A protein NA plasminogen activator inhibitor 1 HYDROLASE 07/15/20 Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 1.88 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 NA NA None None None None None 5mth H L 0 IMMUNE SYSTEM 01/09/17 Structure of DC8E8 Fab at pH 6.5 crystallized in spacegroup P21 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 1.73 X-RAY DIFFRACTION 0.236 0.185 False False IGHV1 IGKV8 Kappa None None None None None 4jlr A B 0 C protein rsv_1isea designed scaffold IMMUNE SYSTEM 03/12/13 Crystal structure of a designed Respiratory Syncytial Virus Immunogen in complex with Motavizumab Rupert, P.B., Correia, B., Schief, W., Strong, R.K. 2.71 X-RAY DIFFRACTION 0.249 0.191 False True IGHV2 IGKV1 Kappa 2.9899999999999995e-11 -14.357753376338442 SPR TBD 7zf6 H L 0 NA NA NA NA IMMUNE SYSTEM 04/01/22 Omi-12 Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Huo, J., Ren, J., Stuart, D.I. 2.21 X-RAY DIFFRACTION 0.265 0.235 False True IGHV1 IGKV3 Kappa None None None None None 4laq H L 0 IMMUNE SYSTEM 06/20/13 Crystal structures of a therapeutic single chain antibody in the free Form and in complex with amphetamine and 4-hydroxymethamphetamine MUS MUSCULUS mus musculus mus musculus Celikel, R., Gokulan, K., Peterson, E.C., Varughese, K.I. 2.8 X-RAY DIFFRACTION 0.270 0.208 False True IGHV3 IGKV4 Kappa None None None None None 6xkr H L 0 P protein NA programmed cell death protein 1 ANTITUMOR PROTEIN/IMMUNE SYSTEM 06/27/20 Structure of Sasanlimab Fab in complex with PD-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kimberlin, C.R., Chin, S.M. 2.59 X-RAY DIFFRACTION 0.271 0.219 False True IGHV1 IGKV4 Kappa None None None None None 3or6 A B 0 C protein voltage-gated potassium channel IMMUNE SYSTEM/TRANSPORT PROTEIN 09/06/10 On the structural basis of modal gating behavior in K+channels - E71Q MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Chakrapani, S., Cordero-Morales, J.F., Jogini, V., Perozo, E. 2.7 X-RAY DIFFRACTION 0.268 0.226 False False IGHV1 IGKV5 Kappa None None None None None 2x7l J K 0 Q protein hiv rev IMMUNE SYSTEM 03/01/10 Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element UNCLASSIFIED; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 BH10 unclassified unclassified human immunodeficiency virus type 3 DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M. 3.17 X-RAY DIFFRACTION 0.2500 0.2337 False True IGHV1 IGKV1 Kappa None None None None None 1dqd H L 0 IMMUNE SYSTEM 01/04/00 CRYSTAL STRUCTURE OF FAB HGR-2 F6, A COMPETITIVE ANTAGONIST OF THE GLUCAGON RECEPTOR MUS MUSCULUS mus musculus mus musculus Wright, L.M., Brzozowski, A.M., Hubbard, R.E., Pike, A.C.W., Roberts, S.M., Skovgaard, R.N., Svendsen, I., Vissing, H., Bywater, R.P. 2.1 X-RAY DIFFRACTION 0.315 0.217 False False IGHV3 IGKV4 Kappa None None None None None 7ooi B NA 0 NA NA NA NA IMMUNE SYSTEM 05/27/21 Anti-EphA1 JD1 VH domain HOMO SAPIENS homo sapiens Ereno-Orbea, J., Nilvebrant, J., Sidhu, S., Julien, J.P. 2.28 X-RAY DIFFRACTION 0.297 0.269 False True IGHV3 NA NA None None None None None 3q6f D C 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 3.192 X-RAY DIFFRACTION 0.243 0.199 False False IGHV3 IGLV3 Lambda None None None None None 5c8j E F 0 J protein protein mj0480 MEMBRANE PROTEIN 06/25/15 A YidC-like protein in the archaeal plasma membrane HOMO SAPIENS; METHANOCALDOCOCCUS JANNASCHII (STRAIN ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) homo sapiens homo sapiens methanocaldococcus jannaschii (strain atcc43067 / dsm 2661 / jal-1 / jcm 10045 / nbrc 100440) Borowska, M.T., Dominik, P.K., Anghel, S.A., Kossiakoff, A.A., Keenan, R.J. 3.502 X-RAY DIFFRACTION 0.302 0.253 False True IGHV3 IGKV1 Kappa None None None None None 7pg8 R P 0 T protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 6x97 E F 0 C protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11A fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3r06 H L 0 IMMUNE SYSTEM 03/07/11 Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius Shore, D.A., Zhu, X., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.191 False True IGHV5 IGKV14 Kappa None None None None None 7uds F G 0 A | a protein | protein NA | NA glycoprotein g2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 03/20/22 Structure of lineage I (Pinneo) Lassa virus glycoprotein bound to Fab 25.10C HOMO SAPIENS; LASSA MAMMARENAVIRUS homo sapiens homo sapiens lassa mammarenavirus | lassa mammarenavirus Buck, T.K., Enriquez, A.E., Hastie, K.M. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2kh2 B b 26 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6vu2 H L 0 IMMUNE SYSTEM 02/14/20 M1214_N1 Fab structure HUMAN IMMUNODEFICIENCY VIRUS human immunodeficiency virus human immunodeficiency virus Pan, R., Kong, X. 2.19 X-RAY DIFFRACTION 0.216 0.177 False True unknown unknown unknown None None None None None 7k75 C D 0 F peptide NA pfcsp n-terminal peptide p17 IMMUNE SYSTEM 09/22/20 Crystal structure of MAD2-6 IgA Fab in complex with PfCSP N-terminal peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.192 False True IGHV4 IGKV1 Kappa None None None None None 3gkz a A 0 A Hapten B40 (2S)-N-METHYL-1-PHENYLPROPAN-2-AMINE IMMUNE SYSTEM 03/11/09 Crystal structures of a therapeutic single chain antibody in complex methamphetamine MUS MUSCULUS mus musculus mus musculus Celikel, R., Peterson, E.C., Owens, M., Varughese, K.I. 1.9 X-RAY DIFFRACTION 0.235 0.210 True True unknown unknown unknown 1e-08 -10.913952715282035 Unknown TBD 5wob O P 0 D protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 3eff D C 0 K | L protein | protein NA | NA voltage-gated potassium channel | voltage-gated potassium channel MEMBRANE PROTEIN 09/08/08 The Crystal Structure of Full-Length KcsA in its Closed Conformation MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans | streptomyces lividans Uysal, S., Vasquez, V., Tereshko, T., Esaki, K., Fellouse,F.A., Sidhu, S.S., Koide, S., Perozo, E., Kossiakoff, A. 3.8 X-RAY DIFFRACTION 0.331 0.270 False False IGHV3 IGKV1 Kappa None None None None None 1v7n J N 0 Y protein thrombopoietin IMMUNE SYSTEM/CYTOKINE 12/18/03 Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R. 3.3 X-RAY DIFFRACTION 0.305 0.167 False True IGHV6 IGKV4 Kappa None None None None None 4rqs D C 0 G protein hiv-1 yu2 gp120 core chimeric protein IMMUNE SYSTEM 11/05/14 Crystal structure of fully glycosylated HIV-1 gp120 core bound to CD4 and 17b Fab CRICETULUS GRISEUS; HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kong, L., Wilson, I.A., Kwong, P.D. 4.493 X-RAY DIFFRACTION 0.322 0.276 False True IGHV1 IGKV3 Kappa None None None None None 6vvu E F 0 C protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 02/18/20 Anti-Tryptase fab E104.v1 bound to tryptase HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Koerber, J.T. 3.0 X-RAY DIFFRACTION 0.232 0.187 False True IGHV4 IGKV1 Kappa None None None None None 5m7q A NA 0 IMMUNE SYSTEM 10/28/16 Engineering the Thermostability of Nanobodies - NbD2 CAMELUS DROMEDARIUS camelus dromedarius Soler, N., Kunz, P., Muyldermans, S. 1.8 X-RAY DIFFRACTION 0.249 0.196 False True IGHV1 None None None None None 1xcq H G 0 S peptide capsid protein c IMMUNE SYSTEM 09/03/04 Complex HCV core-Fab 19D9D6-Protein L mutant (D55A,L57H,Y64W) in space group P21 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 3.5 X-RAY DIFFRACTION 0.264 0.192 False False IGHV9 IGKV8 Kappa None None None None None 6pb1 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(i) subunit alpha- 1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 06/12/19 Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35 HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ma, S., Shen, Q., Zhao, L.-H., Mao, C., Zhou, X.E., Shen, D.-D., de Waal, P.W., Bi, P., Li, C., Jiang, Y., Wang, M.-W., Sexton, P.M., Wootten, D., Melcher, K., Zhang, Y., Xu, H.E. 2.8 ELECTRON MICROSCOPY False True IGHV3 None None None None None 7m6i M N 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, BG1-24 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7lqw H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/15/21 Cryo-EM structure of NTD-directed neutralizing antibody 2-17 Fab in complex with SARS-CoV-2 S2P spike HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gorman, J., Rapp, M., Kwong, P.D., Shapiro, L. 4.47 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sjs H L 0 C peptide NA stem helix peptide of spike protein s2' IMMUNE SYSTEM 10/18/21 Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody CC40.8 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Wilson, I.A. 1.612 X-RAY DIFFRACTION 0.206 0.174 False True IGHV3 IGLV3 Lambda None None None None None 6qkd H NA 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGHV1 None None None None None 6nf5 H L 0 A protein hiv-1 env bg505 md64 n332-gt5 sosip gp120 VIRAL PROTEIN/immune system 12/18/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Steichen, J.M., Schief, W.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 4mhj R Q 0 O protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 6.98 X-RAY DIFFRACTION 0.387 0.377 False True IGHV1 IGKV3 Kappa 1e-09 -12.27819680469229 BLI TBD 7nvl n NA 0 e protein NA unknown CHAPERONE 03/15/21 Human TRiC complex in closed state with nanobody bound (Consensus Map) LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W., Structural Genomics Consortium (SGC) 2.5 ELECTRON MICROSCOPY NA NA False False IGHV1 NA NA None None None None None 4tnv J M 0 E protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False IGHV1 IGLV1 Lambda None None None None None 7bue G I 0 B protein dengue serotype 2 e protein ectodomain VIRUS 05/13/20 Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 7.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7lu9 i j 0 B carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta Manne, K., Edwards, R.J., Acharya, P. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7s6c E G 0 A protein NA 6-deoxyerythronolide-b synthase erya2, modules 3 and 4,lsd14 polyketide synthase fusion BIOSYNTHETIC PROTEIN 09/13/21 CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES LASALOCIDI; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea, streptomyceslasalocidi Bagde, S.R., Kim, C.-Y., Fromme, J.C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 3qnx B A 0 IMMUNE SYSTEM 02/09/11 Orthorhombic form of human IgA1 Fab fragment, sharing same Fv as IgG HOMO SAPIENS homo sapiens homo sapiens Trajtenberg, F., Correa, A., Buschiazzo, A. 2.2 X-RAY DIFFRACTION 0.224 0.181 False False IGHV3 IGKV2 Kappa None None None None None 7cyp E D 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN 09/04/20 Complex of SARS-CoV-2 spike trimer with its neutralizing antibody HB27 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 7kmd A E 0 T protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/20 Crystal structure of a HIV-1 clade C isolate Du172.17 HR1.R4.664 Env trimer in complex with human Fabs PGT124 and 35O22 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 3.39229 X-RAY DIFFRACTION 0.292 0.242 False True unknown unknown unknown None None None None None 6cue Q R 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 3ixy G H 0 A protein envelope protein e VIRUS 02/26/09 The pseudo-atomic structure of dengue immature virus in complex with Fab fragments of the anti-fusion loop antibody E53 DENGUE VIRUS 2; MUS MUSCULUS mus musculus mus musculus dengue virus 2 Cherrier, M.V., Kaufmann, B., Nybakken, G.E., Lok, S.M., Warren, J.T., Nelson, C.A., Kostyuchenko, V.A., Holdaway, H.A., Chipman, P.R., Kuhn, R.J., Diamond, M.S., Rossmann, M.G., Fremont, D.H. 23 ELECTRON MICROSCOPY False True IGHV7 IGKV4 Kappa None None None None None 5ijv F E 0 IMMUNE SYSTEM 03/02/16 Crystal structure of bovine Fab E03 BOS TAURUS bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.247 0.204 False True IGHV1 IGLV1 Lambda None None None None None 7pnq H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/07/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 43E6 antibody Fab fragment HOMO SAPIENS; HUMAN CORONAVIRUS OC43 homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4xwo K L 0 H protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 4hlz G H 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 10/17/12 Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus | influenza a virus Dreyfus, C., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.228 False True IGHV7 IGKV12 Kappa 2e-09 -11.867518412372508 BLI TBD 6hjy G NA 0 B protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.78 X-RAY DIFFRACTION 0.233 0.225 False True IGHV1 None None None None None 1t4k B A 0 IMMUNE SYSTEM 04/29/04 Crystal Structure of Unliganded Aldolase Antibody 93F3 Fab MUS MUSCULUS mus musculus mus musculus Zhu, X., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.281 0.233 False False IGHV2 IGKV8 Kappa None None None None None 4kph I M 0 immune system 05/13/13 Structure of the Fab fragment of N62, a protective monoclonal antibody to the nonreducing end of Francisella tularensis O-antigen MUS MUSCULUS mus musculus mus musculus Lu, Z., Rynkiewicz, M.J., Yang, C.-Y., Madico, G., Perkins, H.M., Wang, Q., Costello, C.E., Zaia, J., Seaton, B.A., Sharon, J. 2.59 X-RAY DIFFRACTION 0.268 0.222 False False IGHV3 IGKV4 Kappa None None None None None 7rga D NA 0 D Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoCLAMP3:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Alexandrov, K. 2.9 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 1ad0 D C 0 IMMUNOGLOBULIN 02/19/97 FAB FRAGMENT OF ENGINEERED HUMAN MONOCLONAL ANTIBODY A5B7 HOMO SAPIENS homo sapiens homo sapiens Banfield, M.J., Brady, R.L. 2.5 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 3u36 E F 0 IMMUNE SYSTEM 10/04/11 Crystal Structure of PG9 Fab HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Kwong, P.D. 3.281 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV2 Lambda None None None None None 5tq2 H L 0 A | B protein | protein NA | NA nmda glutamate receptor subunit | glutamate receptor ionotropic, nmda 2a TRANSPORT PROTEIN 10/21/16 Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at GluN1 and GluN2A RATTUS NORVEGICUS; XENOPUS LAEVIS; MUS MUSCULUS mus musculus mus musculus xenopus laevis | rattus norvegicus Romero-Hernandez, A., Simorowski, N., Karakas, E., Furukawa, H. 3.289 X-RAY DIFFRACTION 0.261 0.224 False False IGHV9 IGKV5 Kappa None None None None None 3chn A L 9 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 3eyv B A 0 IMMUNE SYSTEM 10/22/08 Anti-Lewis Y Fab fragment with Lewis Y antigen in the presence of zinc ions MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Farrugia, W., Scott, A.M., Ramsland, P.A. 2.5 X-RAY DIFFRACTION 0.262 0.210 False True IGHV5 IGKV1 Kappa None None None None None 6dg2 A B 0 IMMUNE SYSTEM 05/16/18 Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6 MUS MUSCULUS mus musculus mus musculus Milligan, J.C., Saphire, E.O. 1.96 X-RAY DIFFRACTION 0.235 0.191 False True IGHV1 IGKV6 Kappa None None None None None 7l2d H L 0 A protein NA spike glycoprotein Viral protein/Immune system 12/16/20 Cryo-EM structure of NTD-directed neutralizing antibody 1-87 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 2p7t A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 03/20/07 Crystal Structure of KcsA mutant STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cordero-Morales, J.F., Vishwanath, J., Lewis, A., Valeria, V.R., Cortes, D.M., Roux, B., Perozo, E. 2.05 X-RAY DIFFRACTION 0.234 0.219 False False IGHV1 IGKV5 Kappa None None None None None 1wc7 H L 0 ANTIBODY 11/09/04 FAB FRAGMENT OF PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH PHOSPHOPYRIDOXYL-L-ALANINE MUS MUSCULUS mus musculus mus musculus PIMPANEAU, B.GOLINELLI-, CHRISTEN, P. 2.33 X-RAY DIFFRACTION unknown unknown False True IGHV7 IGKV4 Kappa None None None None None 7v3j H L 0 A | C | B protein | protein | protein NA | NA | NA envelope protein e | envelope protein e | envelope protein e IMMUNE SYSTEM/VIRUS 08/10/21 DENV2:F(ab')2-local HOMO SAPIENS; DENGUE VIRUS TYPE 2 (STRAIN THAILAND/NGS-C/1944) homo sapiens homo sapiens dengue virus type 2 (strain thailand/ngs-c/1944) | dengue virus type 2 (strain thailand/ngs-c/1944) | dengue virus type 2 (strain thailand/ngs-c/1944) Shu, B., Zhang, S., Victor, A.K., Ng, T.S., Lok, S.M. 4.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 5i6z B C 0 A protein sodium-dependent serotonin transporter MEMBRANE PROTEIN 02/16/16 X-ray structure of the ts2 human serotonin transporter MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Coleman, J.A., Green, E.M., Gouaux, E. 4.53 X-RAY DIFFRACTION 0.317 0.280 False True IGHV1 IGKV6 Kappa None None None None None 5uk0 G g 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 2 HOMO SAPIENS; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 7jwp E F 0 S peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 7rxd N NA 0 R protein NA spike protein s1 STRUCTURAL PROTEIN 08/22/21 CryoEM structure of RBD domain of COVID-19 in complex with Legobody ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS SP.; MUS MUSCULUS; VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 vicugna pacos severe acute respiratory syndrome coronavirus2 Wu, X.D., Rapoport, T.A. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3mck H L 0 IMMUNE SYSTEM 03/29/10 Crystal structure of anti-beta-amyloid antibody C705 MUS MUSCULUS mus musculus mus musculus Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.3 X-RAY DIFFRACTION 0.254 0.203 False True IGHV8 IGKV1 Kappa None None None None None 5u3m H L 0 A peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.11P Fab in Complex with HIV-1 gp41 MPER Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 2.418 X-RAY DIFFRACTION 0.270 0.227 False True IGHV3 IGKV1 Kappa None None None None None 4nc1 F NA 0 B protein cell wall-binding repeat protein IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A2 Bound to A20.1 VHH and A26.8 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 2.61 X-RAY DIFFRACTION 0.252 0.202 False True IGHV1 None None None None None 7np1 H L 0 A protein NA spike protein s1 VIRAL PROTEIN 02/26/21 Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hall, G., Cowan, R., Carr, M. 2.8 X-RAY DIFFRACTION 0.281 0.232 False True IGHV3 IGKV1 Kappa None None None None None 5jz7 H L 0 B protein beta-nerve growth factor SIGNALING PROTEIN 05/16/16 NGF IN COMPLEX WITH MEDI578 scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Olsson, L.-L., Aagaard, A. 3.4 X-RAY DIFFRACTION 0.268 0.258 False True IGHV1 IGLV1 Lambda None None None None None 6ukj H L 0 A protein chloroquine resistance transporter MEMBRANE PROTEIN 10/05/19 Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform PLASMODIUM FALCIPARUM (ISOLATE 7G8); HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum (isolate 7g8) Kim, J., Tan, Y.Z., Wicht, K.J., Erramilli, S.K., Dhingra, S.K., Okombo, J., Vendome, J., Hagenah, L.M., Giacometti, S.I., Warren, A.L., Nosol, K., Roepe, P.D., Potter, C.S., Carragher, B., Kossiakoff, A.A., Quick, M., Fidock, D.A., Mancia, F. 3.3 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 7mf9 G I 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA Fab in space group C2 HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 3.7 X-RAY DIFFRACTION 0.269 0.240 False True IGHV3 IGLV3 Lambda None None None None None 7r40 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/08/22 Structure of the SARS-CoV-2 spike glycoprotein in complex with the 87G7 antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hurdiss, D.L. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4ocn C NA 0 B | A protein | protein NA | NA 26s proteasome regulatory subunit rpn11 | 26s proteasome regulatory subunit rpn8 HYDROLASE, PROTEIN BINDING 01/09/14 Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form II SACCHAROMYCES CEREVISIAE; LAMA GLAMA lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Pathare, G.R., Bracher, A. 2.25 X-RAY DIFFRACTION 0.281 0.232 False True IGHV1 NA NA None None None None None 7l7e M N 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV3 IGKV4 Kappa None None None None None 6cdi 5 6 0 2 protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 1a5f H L 0 IMMUNOGLOBULIN 02/16/98 FAB FRAGMENT OF A MONOCLONAL ANTI-E-SELECTIN ANTIBODY MUS MUSCULUS mus musculus mus musculus Rodriguez-Romero, A., Almog, O., Tordova, M., Randhawa, Z. 2.8 X-RAY DIFFRACTION unknown 0.195 False False IGHV14 IGKV8 Kappa None None None None None 7ke1 A B 0 NA NA NA NA IMMUNE SYSTEM 10/09/20 Factor H enhancing human antibody fragment (Fab) to meningococcal Factor H binding protein HOMO SAPIENS homo sapiens homo sapiens Beernink, P.T., Sands, N. 1.5 X-RAY DIFFRACTION 0.183 0.162 False True IGHV3 IGKV3 Kappa None None None None None 6fg2 H L 0 IMMUNE SYSTEM 01/09/18 CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA84. HOMO SAPIENS homo sapiens homo sapiens Bertrand, T., Pouzieux, S. 2.788 X-RAY DIFFRACTION 0.263 0.238 False True IGHV1 IGKV19 Kappa None None None None None 1nmc B C 0 A protein neuraminidase COMPLEX (SINGLE-CHAIN ANTIBODY/ANTIGEN) 12/21/97 COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 15 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Malby, R.L., Mccoy, A.J., Kortt, A.A., Hudson, P.J., Colman, P.M. 2.5 X-RAY DIFFRACTION 0.260 0.220 False True IGHV1 IGKV10 Kappa None None None None None 3kj4 C B 0 D protein reticulon-4 receptor IMMUNE SYSTEM 11/02/09 Structure of rat Nogo receptor bound to 1D9 antagonist antibody RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Silvian, L.F. 3.1 X-RAY DIFFRACTION 0.318 0.253 False True IGHV2 IGKV8 Kappa None None None None None 7rkf D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein subunit alpha-11 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/22/21 Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state HOMO SAPIENS; MUS MUSCULUS; HUMAN CYTOMEGALOVIRUS mus musculus homo sapiens | homo sapiens Tsutsumi, N., Maeda, S., Qu, Q., Skiniotis, G., Kobilka, B.K., Garcia, K.C. 4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7dcx E H 0 K protein NA sars-cov2 s protein VIRAL PROTEIN 10/27/20 S-3C1-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 3C1 fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 5.9 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 5ywp R Q 0 A protein NA jev e protein IMMUNE SYSTEM 11/29/17 JEV-2H4 Fab complex JAPANESE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus japanese encephalitis virus Qiu, X.D., Lei, Y.F., Yang, P., Gao, Q., WANG, N., Cao, L., Yuan, S., Wang, X.X., Xu, Z.K., Rao, Z.H. 4.6 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV3 Kappa None None None None None 5nyx M N 0 IMMUNE SYSTEM 05/12/17 human Fab fragment 5H2 against NHBA from Neisseria meningitidis HOMO SAPIENS homo sapiens homo sapiens Enrico, M., Maritan, M. 1.88 X-RAY DIFFRACTION 0.226 0.186 False True IGHV4 IGKV1 Kappa None None None None None 3ux9 B b 0 A protein interferon alpha-1/13 CYTOKINE/IMMUNE SYSTEM 12/04/11 Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus HOMO SAPIENS homo sapiens homo sapiens Ouyang, S., Zhao, L.X., Liang, W., Shaw, N., Liu, Z.-J., Liang, M.-F. 2.8 X-RAY DIFFRACTION 0.243 0.183 True True unknown unknown unknown 7.47e-10 -12.45101842491568 SPR TBD 3hpl A B 0 C protein voltage-gated potassium channel IMMUNE SYSTEM/metal TRANSPORT 06/04/09 KcsA E71H-F103A mutant in the closed state STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 3.2 X-RAY DIFFRACTION 0.269 0.220 False True IGHV1 IGKV5 Kappa None None None None None 7ean H L 0 A protein NA spike protein s1 VIRAL PROTEIN 03/07/21 immune complex of SARS-CoV-2 RBD and cross-neutralizing antibody 6D6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Li, T.T., Gu, Y., Li, S.W. 1.91 X-RAY DIFFRACTION 0.224 0.191 False False IGHV14 IGKV6 Kappa None None None None None 7vgz F f 0 C | D protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/20/21 MT1-remalteon-Gi complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Wang, Q.G., Lu, Q.Y. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7jvp N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 08/22/20 Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Zhuang, Y., Xu, P., Mao, C., Wang, L., Krumm, B., Zhou, X.E., Huang, S., Liu, H., Cheng, X., Huang, X.-P., Sheng, D.-D., Xu, T., Liu, Y.-F., Wang, Y., Guo, J., Jiang, Y., Jiang, H., Melcher, K., Roth, B.L., Zhang, Y., Zhang, C., Xu, H.E. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3u30 C B 0 A protein linear di-ubiquitin IMMUNE SYSTEM 10/04/11 Crystal structure of a linear-specific Ubiquitin fab bound to linear ubiquitin HOMO SAPIENS homo sapiens homo sapiens homo sapiens Matsumoto, M.L., Dong, K.C., Yu, C., Phu,L, Gao, X., Hannoush, R.N., Hymowitz, S.G., Kirkpatrick, D.S., Dixit, V.M., Kelley, R.F. 2.428 X-RAY DIFFRACTION 0.258 0.229 False True IGHV3 IGKV1 Kappa None None None None None 7k45 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/14/20 SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5nml B NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 3whe W X 0 F protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 6wyt H L 0 NA NA NA NA IMMUNE SYSTEM 05/13/20 Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1B HOMO SAPIENS homo sapiens homo sapiens Vieni, C., Ekiert, D. 1.75 X-RAY DIFFRACTION 0.222 0.195 False True IGHV4 IGLV3 Lambda None None None None None 7lj4 E D 0 A protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel FHEIG mutant A270P in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.782 X-RAY DIFFRACTION 0.258 0.215 False True IGHV1 IGKV4 Kappa None None None None None 4zg1 C NA 0 PROTEIN BINDING 04/22/15 Crystal structure of a nanobody raised against KDM5b LAMA GLAMA lama glama Wiuf, A., Kristensen, O., Gajhede, M. 1.85 X-RAY DIFFRACTION 0.235 0.186 False True IGHV1 None None None None None 7rm0 G H 0 S peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2E10.E9 in complex with P. vivax CSP peptide ANGAGNQPGANGAGNQPG MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 2.71 X-RAY DIFFRACTION 0.246 0.209 False True IGHV9 IGKV8 Kappa None None None None None 6ol5 H L 0 IMMUNE SYSTEM 04/15/19 Structure of iglb12 Fab in complex with anti-idiotype ib3 Fab MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 2.9 X-RAY DIFFRACTION 0.250 0.200 False True IGHV1 IGKV3 Kappa None None None None None 7wea G I 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with two XGv347 binding to one close state RBD and one open state RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5o03 D NA 0 B protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 protruding domain in complex with Nanobody Nano-32 NORWALK VIRUS; NOROVIRUS norovirus norwalk virus Koromyslova, A.D., Hansman, G.H. 2.194 X-RAY DIFFRACTION 0.193 0.172 False True IGHV1 6.000000000000001e-08 -9.85236447127895 ITC TBD 7qic C NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/14/21 Structure of magnesium-bound EleNRMT in complex with two nanobodies at 4.1A EGGERTHELLA LENTA; SYNTHETIC CONSTRUCT synthetic construct eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7dk7 e f 0 C protein NA sars-cov-2 s protein VIRAL PROTEIN 11/23/20 S-2H2-F3b structure, three RBDs are up and each RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 9.7 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 1yy9 D C 0 A protein epidermal growth factor receptor IMMUNE SYSTEM/Transferase 02/24/05 Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Li, S., Schmitz, K.R., Jeffrey, P.D., Wiltzius, J.J.W., Kussie, P., Ferguson, K.M. 2.605 X-RAY DIFFRACTION 0.289 0.239 False True IGHV2 IGKV5 Kappa 2.30e-09 -11.78 SPR 25 15837620 6ulf A B 0 P | K peptide | protein NA | NA circumsporozoite protein | anti kappa vhh domain IMMUNE SYSTEM 06/17/20 Crystal structure of 4498 Fab in complex with circumsporozoite protein NDN3 and anti-Kappa VHH domain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | camelidae mixed library Thai, E., Scally, S.W., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 1.7 X-RAY DIFFRACTION 0.235 0.207 False True IGHV3 IGKV3 Kappa None None None None None 2kqn NA A 19 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5vqm H L 0 A protein NA toxin b TOXIN/IMMUNE SYSTEM 05/09/17 Clostridium difficile TcdB-GTD bound to PA41 Fab PEPTOCLOSTRIDIUM DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens peptoclostridium difficile Kroh, H.K., Spiller, B.W., Lacy, D.B. 2.79 X-RAY DIFFRACTION 0.292 0.241 False True IGHV1 IGKV3 Kappa None None None None None 1fsk L K 0 J protein major pollen allergen bet v 1-a IMMUNE SYSTEM 09/11/00 COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 BETULA PENDULA; MUS MUSCULUS mus musculus mus musculus betula pendula Mirza, O., Henriksen, A., Ipsen, H., Larsen, J., Wissenbach, M., Spangfort, M., Gajhede, M. 2.9 X-RAY DIFFRACTION 0.285 0.253 False True IGHV1 IGKV6 Kappa 2.4e-10 -13.12373995487015 Unknown TBD 7l6v D NA 0 A protein NA bont/a ANTITOXIN 12/24/20 Crystal structure of BoNT/A-LC-JPU-A5-JPU-C1-JPU-H7-JPU-D12-ciA-F12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.01 X-RAY DIFFRACTION 0.234 0.197 False True IGHV1 NA NA None None None None None 2g5b B A 0 I peptide bax peptide APOPTOSIS 02/22/06 Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Peyerl, F.W., Dai, S., Murphy, G.A., Marrack, P., Kappler, J.W. 2.3 X-RAY DIFFRACTION 0.275 0.234 False True IGHV7 IGKV8 Kappa None None None None None 5c1m B NA 0 A protein mu-type opioid receptor Signaling Protein/antagonist 06/15/15 Crystal structure of active mu-opioid receptor bound to the agonist BU72 LAMA GLAMA; MUS MUSCULUS lama glama mus musculus Huang, W.J., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R., Granier, S., Gmeiner, P., Husbands, S.M., Traynor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilka, B.K. 2.1 X-RAY DIFFRACTION 0.222 0.185 False True IGHV1 None None None None None 5vk6 A B 0 C protein ph-gated potassium channel kcsa IMMUNE SYSTEM/TRANSPORT PROTEIN 04/21/17 Open conformation of KcsA non-inactivating E71A mutant STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Perozo, E. 2.25 X-RAY DIFFRACTION 0.213 0.186 False False IGHV1 IGKV5 Kappa None None None None None 7s4g E F 0 I peptide NA lymphocyte antigen 6 complex locus protein g6d SIGNALING PROTEIN 09/08/21 Fab fragment bound to the Cter peptide of Ly6G6D HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rouge, L., Lupardus, P. 2.2 X-RAY DIFFRACTION 0.235 0.192 False True IGHV1 IGKV4 Kappa None None None None None 5drw A B 0 IMMUNE SYSTEM 09/16/15 Crystal structure of the BCR Fab fragment from subset #4 case CLL183 HOMO SAPIENS homo sapiens homo sapiens Minici, C., Degano, M. 2.27 X-RAY DIFFRACTION 0.241 0.195 False True IGHV4 IGKV2 Kappa None None None None None 5dur B D 0 A protein hemagglutinin IMMUNE SYSTEM 09/20/15 Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4 INFLUENZA A VIRUS (A/ANHUI/1/2005(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1/2005(h5n1)) Zuo, T., Sun, J., Wang, G., Zhou, P., Wang, X., Zhang, L. 2.82 X-RAY DIFFRACTION 0.257 0.208 False True IGHV4 IGLV1 Lambda None None None None None 7f15 B b 0 A protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/07/21 A SARS-CoV-2 neutralizing antibody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, G., Li, X., Guo, Y., Wang, Y., Yuan, S. 2.65 X-RAY DIFFRACTION 0.246 0.201 True True unknown unknown unknown None None None None None 7pc2 K L 0 A protein NA gp120, bg505 sosip.664 t332n VIRAL PROTEIN 08/03/21 HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Fernandez, I., Bontems, F., Pehau-Arnaudet, G., Rey, F. 2.8 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6uuh A B 0 G carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/30/19 Crystal structure of broad and potent HIV-1 neutralizing antibody 438-B11 HOMO SAPIENS; STREPTOCOCCUS SP. 'GROUP G' homo sapiens homo sapiens Kumar, S., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.260 0.227 False True unknown IGKV3 Kappa None None None None None 5kov U u 0 T protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 7tuy H L 0 R protein NA g-protein coupled receptor 183,soluble cytochrome b562fusion IMMUNE SYSTEM 02/03/22 Cryo-EM structure of GSK682753A-bound EBI2/GPR183 HOMO SAPIENS; SYNTHETIC CONSTRUCT; ESCHERICHIA COLI homo sapiens homo sapiens homo sapiens, escherichia coli Chen, H., Huang, W., Li, X. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1ktr H L 0 P peptide oligohistidine peptide antigen IMMUNE SYSTEM 01/17/02 Crystal Structure of the Anti-His Tag Antibody 3D5 Single-Chain Fragment (scFv) in Complex with a Oligohistidine peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kaufmann, M., Lindner, P., Honegger, A., Blank, K., Tschopp, M., Capitani, G., Plueckthun, A., Gruetter, M.G. 2.7 X-RAY DIFFRACTION 0.222 0.190 True True IGHV1 IGKV1 Kappa None None None None None 4ldo B NA 0 A protein lysozyme, beta-2 adrenergic receptor MEMBRANE PROTEIN/HYDROLASE 06/24/13 Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody LAMA GLAMA; ENTEROBACTERIA PHAGE T4, HOMO SAPIENS lama glama enterobacteria phage t4, homo sapiens Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K. 3.2 X-RAY DIFFRACTION 0.254 0.222 False True IGHV1 None None None None None 6xpr E F 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/08/20 Human antibody D2 H1-1/H3-1 H3 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2) INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C., Lee, J. 4.092 X-RAY DIFFRACTION 0.298 0.252 False True IGHV3 IGKV1 Kappa None None None None None 6mui O P 0 N protein NA e2 VIRUS/IMMUNE SYSTEM 10/23/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-42 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.7 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 3fct D C 0 D Hapten MMP N-METHYLMESOPORPHYRIN IMMUNE SYSTEM 06/13/99 MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN HOMO SAPIENS homo sapiens homo sapiens homo sapiens Romesberg, F.E., Santarsiero, B.D., Barnes, D., Yin, J., Spiller, B., Schultz, P.G., Stevens, R.C. 2.4 X-RAY DIFFRACTION 0.293 0.206 False True IGHV1 IGKV6 Kappa None None None None None 5xcr D E 0 F peptide c8 peptide IMMUNE SYSTEM 03/23/17 Crystal structure of P20.1 Fv-clasp fragment with its antigen peptide MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 1.75 X-RAY DIFFRACTION 0.202 0.171 False True IGHV9 IGLV1 Lambda None None None None None 7lvw J NA 0 B protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/26/21 Structure of RSV F in Complex with VHH Cl184 RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama respiratory syncytial virus Hsieh, C.-L., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.230 0.201 False True IGHV1 NA NA None None None None None 5d8j H L 0 A protein fatty acid-binding protein, adipocyte IMMUNE SYSTEM 08/17/15 Development of a therapeutic monoclonal antibody targeting secreted aP2 to treat type 2 diabetes. MUS MUSCULUS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus mus musculus Doyle, C., Birrane, G. 3.0 X-RAY DIFFRACTION 0.269 0.205 False True IGHV1 IGKV4 Kappa 1.78e-09 -11.936562796672279 SPR TBD 6cde q r 0 c protein unknown VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False False unknown IGKV3 Kappa None None None None None 5j74 A a 0 a Hapten 6GN 1-(17-amino-5,8-dioxo-12,15-dioxa-4,9-diazaheptadecan-1-yl)-4-{[3-(3-sulfopropyl)-1,3-benzothiazol-3-ium-2-yl]methyl}quinolin-1-ium IMMUNE SYSTEM 04/05/16 Fluorogen activating protein AM2.2 in complex with TO1-2p HOMO SAPIENS homo sapiens Stanfield, R.L., Wilson, I.A., Wu, Y. 2.7 X-RAY DIFFRACTION 0.250 0.197 True True unknown unknown unknown 1.9e-09 -11.897908852190566 Unknown TBD 6x5m h l 0 r nucleic-acid NA unknown Immune System/RNA 05/26/20 Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Swain, M., Li, M., Wlodawer, A., Le Grice, S.F.J. 2.5 X-RAY DIFFRACTION 0.279 0.207 False False IGHV3 IGKV1 Kappa None None None None None 2zch H L 0 P protein prostate-specific antigen IMMUNE SYSTEM 11/08/07 Crystal structure of human prostate specific antigen complexed with an activating antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Menez, R., Stura, E., Jolivet-Reynaud, C. 2.83 X-RAY DIFFRACTION 0.270 0.203 False False IGHV1 IGKV3 Kappa None None None None None 6t3j H I 0 J protein NA tumor necrosis factor receptor superfamily member 10b APOPTOSIS 10/11/19 Dual Epitope Targeting by Anti-DR5 Antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tauchert, M.J., Augustin, M., Krapp, S., Overdijk, M.B., Breij, E.C.W., Hibbert, R.G. 3.05 X-RAY DIFFRACTION 0.282 0.251 False True IGHV1 IGKV1 Kappa None None None None None 6pzh B A 0 IMMUNE SYSTEM 07/31/19 Crystal structure of human NA-22 Fab HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.236 0.193 False True IGHV3 IGLV2 Lambda None None None None None 7ul2 D NA 0 R protein NA neurotensin receptor 1 MEMBRANE PROTEIN 04/03/22 CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6 Homo sapiens; Lama glama lama glama homo sapiens Robertson, M.J., Skiniotis, G. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7kyl H L 0 E protein NA envelope protein domain iii VIRAL PROTEIN/IMMUNE SYSTEM 12/08/20 Powassan virus Envelope protein DIII in complex with neutralizing Fab POWV-80 POWASSAN VIRUS; MUS MUSCULUS mus musculus mus musculus powassan virus Errico, J.M., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.0 X-RAY DIFFRACTION 0.224 0.190 False False IGHV5 IGKV4 Kappa None None None None None 2f58 H L 0 P peptide protein (hiv-1 gp120) IMMUNE SYSTEM 10/23/98 IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 12-RESIDUE CYCLIC PEPTIDE (INCLUDING RESIDUES 315-324 OF HIV-1 GP120) (MN ISOLATE) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Cabezas, E., Satterthwait, A.C., Stura, E.A., Profy, A.T., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.305 0.185 False False IGHV3 IGKV3 Kappa None None None None None 6p9i A B 0 IMMUNE SYSTEM 06/17/20 crystal structure of human anti staphylococcus aureus antibody STAU-399 Fab HOMO SAPIENS homo sapiens homo sapiens Dong, J., Crowe, J.E. 2.4 X-RAY DIFFRACTION 0.243 0.185 False True IGHV1 IGLV2 Lambda None None None None None 2exy E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 11/09/05 Crystal structure of the E148Q Mutant of EcClC, Fab complexed in absence of bound ions ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lobet, S., Dutzler, R. 3.1 X-RAY DIFFRACTION 0.352 0.328 False False IGHV4 IGKV4 Kappa None None None None None 7v3h I M 0 C protein NA envelope protein e VIRUS/IMMUNE SYSTEM 08/10/21 DENV2_NGC_Fab_C10 28degrees (3Fab:3E) DENGUE VIRUS TYPE 2 (STRAIN THAILAND/NGS-C/1944); HOMO SAPIENS homo sapiens homo sapiens dengue virus type 2 (strain thailand/ngs-c/1944) Shu, B., Zhang, S., Victor, A.K., Ng, T.S., Lok, S.M. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 5mu0 M N 0 W peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 6dwi D C 0 D carbohydrate HD4 4-O-[2-acetamido-2-deoxy-beta-D-glucopyranosyl]-1-O-phosphono-D-ribitol IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 7rqr H L 0 P peptide NA pfcsp peptide nanpnvdp IMMUNE SYSTEM 08/06/21 Structure of chimeric antibody L9heavy_F10light with PfCSP peptide NANPNVDP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Hurlburt, N.K., Pancera, M. 2.23 X-RAY DIFFRACTION 0.238 0.189 False True IGHV3 IGKV1 Kappa None None None None None 6cw3 C D 0 F | E protein | protein NA | NA histone acetyltransferase gcn5 | transcriptional adapter 2 GENE REGULATION 03/29/18 Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 2 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE S288C homo sapiens homo sapiens saccharomyces cerevisiae s288c | saccharomyces cerevisiae s288c Sun, J., Paduch, M., Kim, S.A., Kramer, R.M., Barrios, A.F., Lu, V., Luke, J., Usatyuk, S., Kossiakoff, A.A., Tan, S. 1.98 X-RAY DIFFRACTION 0.227 0.203 False True IGHV3 IGKV1 Kappa None None None None None 2orb H L 0 IMMUNE SYSTEM 02/02/07 The structure of the anti-c-myc antibody 9E10 Fab fragment MUS MUSCULUS mus musculus mus musculus Krauss, N., Scheerer, P., Hoehne, W. 2.2 X-RAY DIFFRACTION 0.317 0.261 False False IGHV5 IGKV3 Kappa None None None None None 5uem H L 0 G protein clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 01/02/17 Crystal structure of 354NC37 Fab in complex with HIV-1 clade AE strain 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Sievers, S.A., Gristick, H.B., Bjorkman, P.J. 2.7 X-RAY DIFFRACTION 0.266 0.220 False True unknown IGKV3 Kappa None None None None None 6ewb G I 0 C protein vp1 VIRAL PROTEIN 11/03/17 Crystal structure of GII.4 UNSW 2012 P domain in complex with Fab 10E9 NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; MUS MUSCULUS mus musculus mus musculus norovirus hu/gii.4/sydney/nsw0514/2012/au Koromyslova, A.D., Hansman, G.S. 2.78 X-RAY DIFFRACTION 0.222 0.186 False True IGHV1 IGKV4 Kappa None None None None None 7teb H L 0 D protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 non-active1-like RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Furukawa, H. 4.23 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV19 Kappa None None None None None 3cle H L 0 NA NA NA NA IMMUNE SYSTEM 03/18/08 HIV neutralizing monoclonal antibody YZ23 MUS MUSCULUS mus musculus mus musculus Jin, L., Paul, S., Symersky, J. 2.5 X-RAY DIFFRACTION 0.272 0.225 False False IGHV1 IGKV6 Kappa None None None None None 4xce A B 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylcholine (06:0 PC); C2 space group HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.93 X-RAY DIFFRACTION 0.247 0.192 False True IGHV1 IGKV3 Kappa None None None None None 3ra7 I M 0 M Hapten DOG DIGOXIGENIN IMMUNE SYSTEM 03/27/11 Bispecific digoxigenin binding antibodies for targeted payload delivery MUS MUSCULUS mus musculus mus musculus mus musculus Hopfner, K.P., Lammens, A. 2.798 X-RAY DIFFRACTION 0.231 0.204 False True IGHV5 IGKV10 Kappa None None None None None 5mtl NA D 0 IMMUNE SYSTEM 01/10/17 Crystal structure of an amyloidogenic light chain HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.45 X-RAY DIFFRACTION 0.277 0.234 False True IGLV1 Lambda None None None None None 3ztn H L 0 A | B | A carbohydrate | protein | protein NAG | NA | NA N-ACETYL-D-GLUCOSAMINE | haemagglutinin | haemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/12/11 Structure of influenza A neutralizing antibody selected from cultures of single human plasma cells in complex with human H1 Influenza haemagglutinin. HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus | influenza a virus Hubbard, P.A., Ritchie, A.J., Corti, D., Voss, J.E., Gamblin, S.J., Codoni, G., Macagno, A., Jarrossay, D., Pinna, D., Minola, A., Vanzetta, F., Silacci, C., Fernandez-Rodriguez, B.M., Agatic, G., Giacchetto-Sasselli, I., Vachieri, S.G., Sallusto, F., Collins, P.J., Haire, L.F., Temperton, N., Langedijk, J.P.M., Skehel, J.J., Lanzavecchia, A. 3.001 X-RAY DIFFRACTION 0.2891 0.2141 False True IGHV3 IGKV4 Kappa None None None None None 2boc A B 0 C protein potassium channel kcsa IMMUNE SYSTEM/TRANSPORT PROTEIN 04/09/05 Potassium channel KcsA-Fab complex in thallium with tetraethylarsonium (TEAs) STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Lenaeus, M.J., Vamvouka, M., Focia, P.J., Gross, A. 3.01 X-RAY DIFFRACTION 0.250 0.222 False False IGHV1 IGKV5 Kappa None None None None None 7jx3 C D 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/26/20 Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Rosen, L.E., Nix, J.C., Corti, D., Veesler, D., Park, Y.J., Walls, A.C., Tortorici, M.A., Cameroni, E., Pinto, D., Beltramello, M. 2.65 X-RAY DIFFRACTION 0.288 0.258 False True IGHV3 IGLV6 Lambda None None None None None 1ngp H L 0 H Hapten NPA 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID IMMUNOGLOBULIN 06/23/95 N1G9 (IGG1-LAMBDA) FAB FRAGMENT COMPLEXED WITH (4-HYDROXY-3-NITROPHENYL) ACETATE MUS MUSCULUS mus musculus mus musculus mus musculus Mizutani, R., Satow, Y. 2.4 X-RAY DIFFRACTION 0.250 0.196 False False IGHV1 IGLV1 Lambda None None None None None 7rq6 J K 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/05/21 Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing NTD-directed CV3-13 Fab isolated from convalescent individual SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, Y., Pozharskiy, E., Tolbert, W.D., Pazgier, M. 4.18 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV1 Kappa None None None None None 4xcc H L 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylcholine (06:0 PC); I422 space group HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.81 X-RAY DIFFRACTION 0.272 0.221 False True IGHV1 IGKV3 Kappa None None None None None 2nr6 F E 0 B protein aspartic protease bla g 2 HYDROLASE/IMMUNE SYSTEM 11/01/06 Crystal structure of the complex of antibody and the allergen Bla g 2 BLATTELLA GERMANICA; MUS MUSCULUS mus musculus mus musculus blattella germanica Li, M., Gustchina, A., Wlodawer, A., Pomes, A., Wunschmann, S. 2.81 X-RAY DIFFRACTION 0.281 0.232 False True IGHV14 IGKV6 Kappa None None None None None 7n9b D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/17/21 Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB21 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Sun, D., Zhang, C., Shi, Y. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6war J NA 0 I protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 1nak I M 0 Q peptide peptide mp1 IMMUNE SYSTEM 11/27/02 IGG1 FAB FRAGMENT (83.1) COMPLEX WITH 16-RESIDUE PEPTIDE (RESIDUES 304-321 OF HIV-1 GP120 (MN ISOLATE)) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Ghiara, J.B., Ollmann Saphire, E., Profy, A.T., Wilson, I.A. 2.57 X-RAY DIFFRACTION 0.326 0.288 False False IGHV3 IGKV1 Kappa None None None None None 6a96 L NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/11/18 Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Liu, S., Xu, L., Guan, F., Liu, Y.T., Cui, Y., Zhang, Q., Bi, G.Q., Zhou, Z.H., Zhang, X., Ye, S. 3.51 ELECTRON MICROSCOPY False True IGHV1 None None None None None 7wd7 c d 0 B protein NA light chain of s5d2 fab VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with three S5D2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 6vmk o n 0 p protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False False IGHV1 IGKV1 Kappa None None None None None 3g5v B A 0 C peptide epidermal growth factor receptor peptide IMMUNE SYSTEM 02/05/09 Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Garrett, T.P.J., Burgess, A.W., Huyton, T., Xu, Y. 2.001 X-RAY DIFFRACTION 0.279 0.226 False True IGHV3 IGKV14 Kappa 8.50e-08 -9.64 SPR 25 19289842 5mu0 I J 0 U peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 1uwe V U 0 ANTIBODY 02/05/04 MOLECULAR MECHANISM OF ENANTIOSELECTIVE PROTON TRANSFER TO CARBON IN CATALYTIC ANTIBODY 14D9 MUS MUSCULUS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Baumann, U., Reymond, J.L. 2.67 X-RAY DIFFRACTION 0.271 0.218 False True IGHV1 IGKV6 Kappa None None None None None 7jwp M N 0 W peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 4dvr H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/TRANSCRIPTION INHIBITOR 02/23/12 Crystal structure of YU2 gp120 core in complex with Fab 48d and NBD-557 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (ISOLATE YU2) homo sapiens homo sapiens human immunodeficiency virus type 1 (isolateyu2) Kwon, Y.D., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.289 0.228 False True IGHV1 IGKV1 Kappa None None None None None 3bkc H L 0 IMMUNE SYSTEM 12/06/07 Crystal structure of anti-amyloid beta FAB WO2 (P21, FormB) MUS MUSCULUS mus musculus mus musculus Miles, L.A., Wun, K.S., Crespi, G.A., Fodero-Tavoletti, M., Galatis, D., Bageley, C.J., Beyreuther, K., Masters, C.L., Cappai, R., McKinstry, W.J., Barnham, K.J., Parker, M.W. 1.9 X-RAY DIFFRACTION 0.236 0.179 False False IGHV8 IGKV1 Kappa None None None None None 2gjz H L 0 IMMUNE SYSTEM 03/31/06 Structure of Catalytic Elimination Antibody 13G5 from a crystal in space group P2(1) MUS MUSCULUS mus musculus mus musculus Debler, E.W., Wilson, I.A. 2.65 X-RAY DIFFRACTION 0.250 0.213 False False IGHV2 IGKV1 Kappa None None None None None 7x6o I K 0 G | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/07/22 Cryo-EM structure of H1 hemagglutinin from A/Washington/05/2011 in complex with a neutralizing antibody 28-12 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Cong, Y., Liu, C.X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7s8h B C 0 A protein NA glycoprotein g2 VIRAL PROTEIN/IMMUNE SYSTEM 09/17/21 Structure of Lassa virus glycoprotein bound to Fab 18.5C and Fab 36.1F LASSA VIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa virus Hastie, K.M., Enriquez, A.S. 2.7 X-RAY DIFFRACTION 0.251 0.218 False True IGHV4 IGKV3 Kappa None None None None None 5ocy H L 0 C peptide cii-c-48-cit IMMUNE SYSTEM 07/04/17 Crystal structure of ACPA E4 in complex with CII-C-48-CIT HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Dobritzsch, D., Ge, C., Holmdahl, R. 2.6 X-RAY DIFFRACTION 0.245 0.187 False True IGHV4 IGLV1 Lambda None None None None None 5uy3 A B 0 IMMUNE SYSTEM 02/23/17 Crystal structure of human Fab PGT144, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Lee, J.H., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.282 0.241 False True unknown IGKV2 Kappa None None None None None 6ir1 B NA 0 A protein mcherry fluorescent protein FLUORESCENT PROTEIN 11/09/18 Crystal structure of red fluorescent protein mCherry complexed with the nanobody LaM4 at 1.9 Angstron resolution ANAPLASMA MARGINALE; CAMELUS BACTRIANUS camelus bactrianus anaplasma marginale Ding, Y., Wang, Z.Y., Hu, R.T., Chen, X. 1.919 X-RAY DIFFRACTION 0.232 0.180 False True IGHV1 None None None None None 7e72 A B 0 E protein NA angiopoietin-1 receptor MEMBRANE PROTEIN 02/25/21 Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kim, H.M., Jo, G.H., Hong, H.J., Han, A. 2.094 X-RAY DIFFRACTION 0.233 0.183 False True IGHV1 IGKV9 Kappa None None None None None 7ps4 B C 0 A protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-38 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 1.94 X-RAY DIFFRACTION 0.231 0.204 False True IGHV5 IGLV1 Lambda None None None None None 7k8z H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C135 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6cyf M L 0 I protein type iii secretion system protein IMMUNE SYSTEM 04/05/18 PcrV fragment with bound Fab PSEUDOMONAS AERUGINOSA; HOMO SAPIENS homo sapiens homo sapiens pseudomonas aeruginosa Oganesyan, V. 2.78 X-RAY DIFFRACTION 0.249 0.215 False True IGHV3 IGKV1 Kappa None None None None None 5jyl D d 0 C protein cadherin-3 CELL ADHESION/IMMUNE SYSTEM 05/14/16 Human P-cadherin MEC1 with scFv TSP7 bound MUS MUSCULUS; HOMO SAPIENS mus musculus homo sapiens Caaveiro, J.M.M., Kudo, S., Tsumoto, K. 2.55 X-RAY DIFFRACTION 0.271 0.214 True True unknown unknown unknown 8.7e-09 -10.996463217420198 SPR TBD 3upc B NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 2kqn NA B 11 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7w2z S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/24/21 Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Qin, J., Ming, Q., Ji, S., Mao, C., Shen, D., Zhang, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5tbd E F 0 I peptide merozoite surface protein 2 IMMUNE SYSTEM 09/12/16 Crystal Structure of anti-MSP2 Fv fragment (mAb4D11) in complex with 3D7-MSP2 215-222 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum 3d7 Seow, J., Morales, R.A.V., MacRaild, C.A., Bankala, K., Drinkwater, N., Dingjan, T., Jaipuria, G., Wilde, K., Anders, R.F., Atreya, H.S., Christ, D., McGowan, S., Norton, R.S. 2.2 X-RAY DIFFRACTION 0.247 0.207 False True IGHV14 IGKV1 Kappa None None None None None 6xrj C D 0 NA NA NA NA IMMUNE SYSTEM 07/13/20 Crystal structure of the disulfide linked DH717.1 Fab dimer, derived from a macaque HIV-1 vaccine-induced Env glycan-reactive neutralizing antibody B cell lineage HOMO SAPIENS homo sapiens homo sapiens Manne, K., Nicely, N.I., Acharya, P. 3.15 X-RAY DIFFRACTION 0.282 0.245 False True IGHV4 IGLV2 Lambda None None None None None 5b3j E F 0 C protein glutamate receptor ionotropic, nmda 2b TRANSPORT PROTEIN 03/01/16 Activation of NMDA receptors and the mechanism of inhibition by ifenprodil RATTUS NORVEGICUS; XENOPUS LAEVIS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Karakas, E., Grant, T., Simorowski, N., Diaz-Avalos, R., Grigorieff, N., Furukawa, H. 2.9 X-RAY DIFFRACTION 0.302 0.273 False False IGHV5 IGKV19 Kappa None None None None None 4ktd H L 0 IMMUNE SYSTEM 05/20/13 Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE136, from non-human primate MACACA MULATTA macaca mulatta macaca mulatta Poulsen, C., Tran, K., Standfield, R., Wyatt, R.T. 2.0 X-RAY DIFFRACTION 0.243 0.214 False True IGHV4 IGLV5 Lambda None None None None None 5k9k A B 0 I protein hemagglutinin IMMUNE SYSTEM 05/31/16 Crystal structure of multidonor HV6-1-class broadly neutralizing Influenza A antibody 56.a.09 in complex with Hemagglutinin Hong Kong 1968. HOMO SAPIENS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2) homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.97 X-RAY DIFFRACTION 0.265 0.225 False True IGHV6 IGKV3 Kappa None None None None None 1za6 B A 0 IMMUNE SYSTEM 04/05/05 The structure of an antitumor CH2-domain-deleted humanized antibody HOMO SAPIENS homo sapiens homo sapiens Larson, S.B., Day, J.S., Glaser, S., Braslawsky, G., McPherson, A. 2.8 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV4 Kappa None None None None None 5w9l E F 0 D protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6p8d D E 0 F peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/10/20 Vaccine-elicited murine FP-targeting antibody vFP6.01 in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 2.102 X-RAY DIFFRACTION 0.309 0.271 False False IGHV1 IGKV2 Kappa None None None None None 6a3w A B 0 C protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 06/17/18 Complex structure of 4-1BB and utomilumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F. 2.0 X-RAY DIFFRACTION 0.215 0.185 False True IGHV5 IGLV3 Lambda None None None None None 1mcq NA B 0 P peptide peptide n-acetyl-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 6oyh F NA 0 B protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/14/19 Crystal structure of MraY bound to carbacaprazamycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 2.95 X-RAY DIFFRACTION 0.268 0.249 False True IGHV1 None None None None None 7ws3 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7k3b H G 0 A | B protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation C, central helices splay INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 1yc8 B NA 0 IMMUNE SYSTEM 12/22/04 cAbAn33- Y37V/E44G/R45L triple mutant CAMELUS DROMEDARIUS camelus dromedarius Conrath, K., Vincke, C., Stijlemans, B., Schymkowitz, J., Wyns, L., Muyldermans, S., Loris, R. 2.7 X-RAY DIFFRACTION 0.324 0.246 False True IGHV1 None None None None None 2j6e H L 0 A protein ig gamma-1 chain c region IMMUNE SYSTEM 09/28/06 Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation HOMO SAPIENS homo sapiens homo sapiens homo sapiens Duquerroy, S., Stura, E.A., Bressanelli, S., Browne, H., Beale, D., Hamon, M., Casali, P., Vaney, M.-C., Rey, F.A., Sutton, B.J., Taussig, M.J. 3.0 X-RAY DIFFRACTION 0.2877 0.2234 False True IGHV4 IGLV1 Lambda 6e-07 -8.488120381868695 Unknown TBD 3zkm C D 0 B protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 01/23/13 BACE2 FAB COMPLEX HOMO SAPIENS; MUS MUSCULUS homo sapiens mus musculus homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 1.85 X-RAY DIFFRACTION 0.24545 0.21077 False True IGHV2 IGKV3 Kappa None None None None None 6v8x K L 0 I protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7lvw G NA 0 A protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/26/21 Structure of RSV F in Complex with VHH Cl184 RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama respiratory syncytial virus Hsieh, C.-L., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.230 0.201 False True IGHV1 NA NA None None None None None 2bse E NA 0 A protein receptor binding protein RECEPTOR 05/20/05 Structure of Lactococcal Bacteriophage p2 Receptor Binding Protein in complex with a llama VHH domain LACTOCOCCUS LACTIS PHAGE P2; LAMA GLAMA lama glama lactococcus lactis phage p2 Spinelli1, S., Desmyter, A., Verrips, C.T., deHaard, H.J.W., Moineau, S., Cambillau, C. 2.7 X-RAY DIFFRACTION 0.294 0.251 False True IGHV1 None None None None None 6xm2 H G 0 K protein NA transforming growth factor beta-2 CYTOKINE/IMMUNE SYSTEM 06/29/20 The structure of the 4A11.v7 antibody in complex with human TGFb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lupardus, P.J., Yin, J.P. 1.91 X-RAY DIFFRACTION 0.244 0.205 False True IGHV4 IGKV3 Kappa None None None None None 3iy5 B A 0 IMMUNE SYSTEM 04/09/09 Variable domains of the mouse Fab (1AIF) fitted into the cryoEM reconstruction of the virus-Fab 16 complex MUS MUSCULUS mus musculus mus musculus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Chipman, P.R., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 18 ELECTRON MICROSCOPY False False IGHV6 IGKV4 Kappa None None None None None 5mvg NA B 0 IMMUNE SYSTEM 01/16/17 Crystal structure of non-amyloidogenic light chain dimer M7 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.2 X-RAY DIFFRACTION 0.239 0.207 False False IGLV3 Lambda None None None None None 7eya H L 0 R protein NA spike glycoprotein VIRAL PROTEIN 05/30/21 Local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-804 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J. 3.77 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1oau NA M 0 IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 1.8 X-RAY DIFFRACTION 0.264 0.226 False True IGLV1 Lambda 2.00e-08 Other 20 12610298 7n28 J K 0 F protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/28/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Gao, F. 4.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6qd7 X Z 0 F | E protein | protein NA | NA envelope glycoprotein | envelope glycoprotein,virion spike glycoprotein,ebov-gp1 VIRAL PROTEIN 01/01/19 EM structure of a EBOV-GP bound to 3T0331 neutralizing antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus | ebola virus Diskin, R., Cohen-Dvashi, H. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5tlj H G 0 IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 3.5 X-RAY DIFFRACTION 0.356 0.283 False True IGHV5 IGKV3 Kappa None None None None None 6xjz C D 0 B nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - apo form HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 2.488 X-RAY DIFFRACTION 0.264 0.200 False True IGHV3 IGKV1 Kappa None None None None None 7v35 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/10/21 Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GCGR-Gs complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhao, F.h., Zhou, Q.T., Cong, Z.T., Hang, K.N., Zou, X.Y., Zhang, C., Chen, Y., Dai, A.T., Liang, A.Y., Ming, Q.Q., Wang, M., Chen, L.N., Xu, P.Y., Chang, R.L., Feng, W.B., Xia, T., Zhang, Y., Wu, B.L., Yang, D.H., Zhao, L.H., Xu, H.E., Wang, M.W. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3lev H L 0 A protein rna polymerase sigma factor IMMUNE SYSTEM 01/15/10 HIV-1 antibody 2F5 in complex with epitope scaffold ES2 THERMUS AQUATICUS; HOMO SAPIENS homo sapiens homo sapiens thermus aquaticus Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.253 0.201 False True IGHV2 IGKV1 Kappa 6.00e-10 -12.8 SPR 20876137 6u1n H L 0 C | R protein | protein NA | NA beta-arrestin-1 | muscarinic acetylcholine receptor m2, vasopressin v2receptor chimera SIGNALING PROTEIN/IMMUNE SYSTEM 08/16/19 GPCR-Beta arrestin structure in lipid bilayer HOMO SAPIENS; RATTUS NORVEGICUS homo sapiens homo sapiens rattus norvegicus | homo sapiens Staus, D.P., Hu, H., Robertson, M.J., Kleinhenz, A.L.W., Wingler, L.M., Capel, W.D., Latorraca, N.R., Lefkowitz, R.J., Skiniotis, G. 4 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6v6w F H 0 C protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/06/19 Crystal structure of antibody 438-B11 DSS mutant (Cys98A-100aA) in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 6.5 X-RAY DIFFRACTION 0.355 0.309 False True unknown IGKV3 Kappa None None None None None 7pr0 C B 0 A protein NA spike protein s1 VIRAL PROTEIN 09/20/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FD-5D Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.92 X-RAY DIFFRACTION 0.251 0.214 False True IGHV3 IGKV2 Kappa None None None None None 3zhk A NA 0 12/22/12 The crystal structure of single domain antibody 2x1 scaffold ESCHERICHIA COLI Song, H.-N., Woo, E.-J., Lim, H.-K. 1.962 X-RAY DIFFRACTION 0.2977 0.2528 False True IGHV3 None None None None None 7zwm D E 0 A protein NA gametocyte surface protein p45/48 CELL ADHESION 05/19/22 Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 3.69 X-RAY DIFFRACTION 0.280 0.255 False True IGHV5 IGKV8 Kappa None None None None None 6lun A B 0 NA NA NA NA STRUCTURAL PROTEIN 01/30/20 NN2101 Antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Kim, H.N., Seo, M.D., Park, S.K. 1.9 X-RAY DIFFRACTION 0.210 0.165 False True IGHV3 IGKV2 Kappa None None None None None 7rdl D C 0 NA NA NA NA IMMUNE SYSTEM 07/09/21 Crystal structure of PCDN-22A, an anti-HIV antibody from the PCDN bnAb lineage HOMO SAPIENS homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 2.71 X-RAY DIFFRACTION 0.258 0.230 False True IGHV4 IGKV3 Kappa None None None None None 6qv2 E NA 0 B protein uncharacterized abc transporter atp-binding proteintm_0288 MEMBRANE PROTEIN 03/01/19 Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); VICUGNA PACOS vicugna pacos thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 4.23 X-RAY DIFFRACTION 0.330 0.306 False True IGHV1 None None None None None 4rau N M 0 O protein platelet factor 4 IMMUNE SYSTEM 09/11/14 crystal structure of RTOFab in complex with human PF4 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 3.74 X-RAY DIFFRACTION 0.284 0.243 False True IGHV5 IGKV10 Kappa None None None None None 2kqn NA B 18 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 2r29 H L 0 A protein envelope protein e Viral protein/Immune system 08/24/07 Neutralization of dengue virus by a serotype cross-reactive antibody elucidated by cryoelectron microscopy and x-ray crystallography DENGUE VIRUS 2 THAILAND/16681/84; MUS MUSCULUS mus musculus mus musculus dengue virus 2 thailand/16681/84 Lok, S.M., Kostyuchenko, V.K., Nybakken, G.E., Holdaway,H.A, Battisti, A.J., Sukupolvi-petty,S., Sedlak,D., Fremont, D.H., Chipman, P.R., Roehrig, J.T., Diamond, M.S., Kuhn, R.J., Rossmann, M.G. 3.0 X-RAY DIFFRACTION 0.321 0.259 False False IGHV14 IGKV3 Kappa None None None None None 5mvj C D 0 IMMUNE SYSTEM 01/16/17 Structure of DC8E8 Fab at pH 6.5 crystallized in space-group P1 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.5 X-RAY DIFFRACTION 0.272 0.219 False False IGHV1 IGKV8 Kappa None None None None None 7kew H K 0 B protein NA spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-43 BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus Murin, C.D., Ward, A.B. 4.16 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6wex H L 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 04/03/20 Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H6 Hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Harshbarger, W.D., Lockbaum, G.J., Deming, D.T., Attatippaholkun, N., Schiffer, C.A., Marasco, W.A. 3.49 X-RAY DIFFRACTION 0.333 0.276 False True IGHV3 IGLV1 Lambda None None None None None 7spa C NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus Hyaluronan Synthase in the GlcNAc-primed, channel-open state LAMA GLAMA; PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5e5m H NA 0 G protein cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 10/08/15 Crystal structure of mouse CTLA-4 in complex with nanobody MUS MUSCULUS mus musculus mus musculus Fedorov, A.A., Fedorov, E.V., Samanta, D., Bonanno, J.B., Almo, S.C. 2.182 X-RAY DIFFRACTION 0.247 0.193 False True IGHV1 None None None None None 3cfd B A 0 B Hapten SPB 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID IMMUNE SYSTEM 03/03/08 Purple-fluorescent antibody EP2-25C10 in complex with its stilbene hapten MUS MUSCULUS mus musculus mus musculus mus musculus Debler, E.W., Heine, A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.243 0.211 False False IGHV3 IGKV10 Kappa None None None None None 7so9 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.2 delta variant + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4qci H L 0 C protein platelet-derived growth factor subunit b CYTOKINE/CYTOKINE RECEPTOR 05/12/14 PDGF-B blocking antibody bound to PDGF-BB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kuai, J., Mosyak, L., Tam, M., LaVallie, E., Pullen, N., Carven, G. 2.3 X-RAY DIFFRACTION 0.247 0.211 False True IGHV3 IGLV3 Lambda 2.8e-11 -14.396652282221849 SPR TBD 2mmx NA A 13 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 4r9y H L 0 B | D protein | protein NA | NA platelet factor 4 | platelet factor 4 IMMUNE SYSTEM/Cytokine 09/08/14 Crystal structure of KKOFab in complex with platelet factor 4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 4.11 X-RAY DIFFRACTION 0.382 0.317 False True IGHV1 IGKV6 Kappa None None None None None 6p67 A B 0 K protein NA interleukin-7 receptor subunit alpha IMMUNE SYSTEM 06/03/19 Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Walsh, S.T.R., Kashi, L., Kohnhorst, C.L. 2.9 X-RAY DIFFRACTION 0.266 0.249 False True IGHV1 IGKV6 Kappa None None None None None 4edx H L 0 V protein beta-nerve growth factor immune system 03/27/12 Nerve Growth Factor in Complex with Fab from mouse mAb 911 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Eigenbrot, C., Ultsch, M. 2.5 X-RAY DIFFRACTION 0.258 0.208 False True IGHV2 IGKV10 Kappa None None None None None 7u8m T U 0 G protein NA hemagglutinin ha1 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 5.39 X-RAY DIFFRACTION 0.342 0.304 False True IGHV4 IGKV1 Kappa None None None None None 3cm9 D O 8 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7kr5 M N 0 D | C protein | protein NA | NA calcium release-activated calcium channel protein 1 | calcium release-activated calcium channel protein 1 TRANSPORT PROTEIN/IMMUNE SYSTEM 11/18/20 Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster | drosophila melanogaster Long, S.B., Hou, X., Outhwaite, I.R. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV10 IGKV6 Kappa None None None None None 2kh2 B b 2 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 1mhp X Y 0 B protein integrin alpha 1, (residues 169-360) IMMUNE SYSTEM 08/20/02 Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Karpusas, M., Taylor, F., Ferrant, J., Weinreb, P., Garber, E. 2.8 X-RAY DIFFRACTION 0.272 0.213 False True IGHV3 IGKV1D Kappa None None None None None 3ze1 E F 0 C protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 3.0 X-RAY DIFFRACTION 0.2330 0.1749 False True IGHV14 IGKV14 Kappa None None None None None 3v0a C NA 0 A protein bont/a TOXIN 12/07/11 2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA CLOSTRIDIUM BOTULINUM; LAMA GLAMA lama glama clostridium botulinum Gu, S., Rumpel, S., Zhou, J., Strotmeier, J., Bigalke, H., Perry, K., Shoemaker, C.B., Rummel, A., Jin, R. 2.703 X-RAY DIFFRACTION 0.224 0.176 False True IGHV1 None None None None None 7np1 J N 0 C protein NA spike protein s1 VIRAL PROTEIN 02/26/21 Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hall, G., Cowan, R., Carr, M. 2.8 X-RAY DIFFRACTION 0.281 0.232 False True IGHV3 IGKV1 Kappa None None None None None 3idm B A 0 C peptide gp41 mper peptide analog IMMUNE SYSTEM 07/21/09 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 Fab' fragment in complex with gp41 Peptide analog ELD(Nrg)WAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.236 0.229 False False IGHV2 IGKV1 Kappa None None None None None 3v0w H L 0 H carbohydrate KDO polysaccharide IMMUNE SYSTEM 12/08/11 Crystal structure of Fab WN1 222-5 in complex with LPS MUS MUSCULUS mus musculus mus musculus mus musculus Gomery, K., Evans, S.V. 1.73 X-RAY DIFFRACTION 0.231 0.182 False False IGHV7 IGKV15 Kappa None None None None None 3chn D N 5 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 5c7k A B 0 C protein NA envelope glycoprotein gp120 IMMUNE SYSTEM 06/24/15 Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, L., Stanfield, R.L., Wilson, I.A. 4.6019 X-RAY DIFFRACTION 0.295 0.289 False True unknown IGLV2 Lambda None None None None None 7k4n C D 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/15/20 SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7p77 Y NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7mjj D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5udc E G 0 D protein fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F A2 Bound to MEDI8897 HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2) homo sapiens homo sapiens human respiratory syncytial virus a (straina2) McLellan, J.S. 3.45 X-RAY DIFFRACTION 0.232 0.175 False True IGHV1 IGKV1 Kappa None None None None None 6h5n F E 0 D protein gametocyte surface protein p45/48 CELL INVASION 07/25/18 Plasmodium falciparum Pfs48/45 C-terminal domain bound to monoclonal antibody 85RF45.1 PLASMODIUM FALCIPARUM; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus plasmodium falciparum Lennartz, F., Higgins, M.K. 3.23 X-RAY DIFFRACTION 0.282 0.261 False True IGHV5 IGLV3 Lambda None None None None None 4wht O P 0 o peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 1oaz J N 0 B protein thioredoxin 1 IMMUNE SYSTEM 01/21/03 IgE Fv SPE7 complexed with a recombinant thioredoxin RATTUS RATTUS; ESCHERICHIA COLI rattus rattus rattus rattus escherichia coli James, L.C., Roversi, P., Tawfik, D. 2.78 X-RAY DIFFRACTION 0.276 0.208 False True IGHV1 IGLV1 Lambda None None None None None 4edx B A 0 W protein beta-nerve growth factor immune system 03/27/12 Nerve Growth Factor in Complex with Fab from mouse mAb 911 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Eigenbrot, C., Ultsch, M. 2.5 X-RAY DIFFRACTION 0.258 0.208 False True IGHV2 IGKV10 Kappa None None None None None 4n1h B NA 0 A protein beta-lactamase HYDROLASE/IMMUNE SYSTEM 10/04/13 Structure of a single-domain camelid antibody fragment cAb-F11N in complex with the BlaP beta-lactamase from Bacillus licheniformis LAMA GLAMA; BACILLUS LICHENIFORMIS lama glama bacillus licheniformis Pain, C., Kerff, F., Herman, R., Sauvage, E., Preumont, S., Charlier, P., Dumoulin, M. 3.0 X-RAY DIFFRACTION 0.284 0.208 False True IGHV1 None None None None None 5f8q D NA 0 B protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain S831 in complex with Nanobody Nb-ER19 HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.59 X-RAY DIFFRACTION 0.230 0.195 False True IGHV1 None None None None None 7kfx H L 0 A protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-C2 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.226 X-RAY DIFFRACTION 0.226 0.191 False True IGHV3 IGKV1 Kappa None None None None None 1kel H L 0 H Hapten AAH ? CATALYTIC ANTIBODY 04/16/96 CATALYTIC ANTIBODY 28B4 FAB FRAGMENT COMPLEXED WITH HAPTEN (1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO] METHYLPHOSPHONIC ACID) MUS MUSCULUS mus musculus mus musculus mus musculus Hsieh-Wilson, L.C., Schultz, P.G., Stevens, R.C. 1.9 X-RAY DIFFRACTION 0.258 0.199 False False IGHV7 IGKV1 Kappa 3.70e-08 -9.83 SPR 11535051 3zlq C NA 0 A protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 02/04/13 BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kuglstatter, A., Stihle, M. 2.1 X-RAY DIFFRACTION 0.29601 0.23825 False True IGHV3 None None None None None 7wpe U V 0 A protein NA spike glycoprotein VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with two JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7r63 B NA 0 NA NA NA NA IMMUNE SYSTEM 06/22/21 Nb82, a nanobody against voltage gated sodium channels Nav1.4 and Nav1.5 LAMA GLAMA lama glama Srinivasan, L., Gabelli, S.B. 2.0 X-RAY DIFFRACTION 0.244 0.184 False True IGHV1 NA NA None None None None None 1riv H L 0 H Hapten OBE 3-(3-HYDROXY-BENZOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 11/18/03 Anti-Cocaine Antibody M82G2 Complexed With meta-Oxybenzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Petsko, G., Ringe, D. 2.2 X-RAY DIFFRACTION 0.215 0.172 False False IGHV6 IGKV2 Kappa None None None None None 6rnn H L 0 IMMUNE SYSTEM 05/09/19 P46, an immunodominant surface protein from Mycoplasma hyopneumoniae MUS MUSCULUS mus musculus mus musculus Guasch, A., Fita, I. 1.735 X-RAY DIFFRACTION 0.256 0.222 False True IGHV3 IGKV3 Kappa None None None None None 5i30 H L 0 IMMUNE SYSTEM 02/09/16 Crystal structure of the human astrovirus 2 neutralizing monoclonal antibody PL-2 Fab fragment at 1.9 A resolution MUS MUSCULUS mus musculus mus musculus Bogdanoff, W.A., DuBois, R.M. 1.9 X-RAY DIFFRACTION 0.221 0.180 False False IGHV2 IGKV10 Kappa None None None None None 3cm9 B M 3 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5mu0 G H 0 T peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 5dfw H h 0 A protein cd81 antigen CELL ADHESION 08/27/15 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT K13 MUS MUSCULUS; HOMO SAPIENS mus musculus homo sapiens Harris, S.F., Villasenor, A., Kuglstatter, A. 2.33 X-RAY DIFFRACTION 0.264 0.190 True True unknown unknown unknown 5e-10 -12.68887519701207 SPR TBD 7tfo I J 0 B protein NA envelope glycoprotein bg505 sosip.664 - gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/06/22 Cryo-EM structure of HIV-1 Env trimer BG505 SOSIP.664 in complex with CD4bs antibody Ab1573 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7tyv G K 0 B | b protein | protein NA | NA glycoprotein g2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 02/14/22 Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C LASSA VIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa virus | lassa virus Enriquez, A.S., Hastie, K.M. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4ybq D C 0 B protein solute carrier family 2, facilitated glucose transportermember 5 TRANSPORT PROTEIN/IMMUNE SYSTEM 02/19/15 Rat GLUT5 with Fv in the outward-open form MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Nomura, N., Shimamura, T., Iwata, S. 3.27 X-RAY DIFFRACTION 0.288 0.242 False True IGHV5 IGKV1 Kappa None None None None None 5f88 B A 0 IMMUNE SYSTEM 12/09/15 Cetuximab Fab in complex with L5Y meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.481 X-RAY DIFFRACTION 0.217 0.163 False True IGHV2 IGKV5 Kappa None None None None None 4qhk O P 0 IMMUNE SYSTEM 05/28/14 UCA (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.487 X-RAY DIFFRACTION 0.285 0.269 False True IGHV4 IGLV3 Lambda None None None None None 3ulu H L 0 A protein toll-like receptor 3 IMMUNE SYSTEM 11/11/11 Structure of quaternary complex of human TLR3ecd with three Fabs (Form1) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 3.52 X-RAY DIFFRACTION 0.309 0.268 False True IGHV5 IGKV1 Kappa None None None None None 3chn D N 7 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 1b0w NA A 0 IMMUNE SYSTEM 11/13/98 Structural comparison of amyloidogenic light chain dimer in two crystal forms with nonamyloidogenic counterparts HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 1.8 X-RAY DIFFRACTION 0.299 0.226 False True IGKV1 Kappa None None None None None 7aql A a 0 NA NA NA NA IMMUNE SYSTEM 10/22/20 Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7) MUS MUSCULUS mus musculus Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 1.8 X-RAY DIFFRACTION 0.223 0.186 True True unknown unknown unknown None None None None None 6u8k H L 0 A nucleic-acid jiiiabc rna (68-mer) RNA/Immune System 09/05/19 Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepacivirus c Koirala, D., Lewicka, A., Koldobskaya, Y., Huang, H., Piccirilli, J.A. 2.75 X-RAY DIFFRACTION 0.222 0.186 False True IGHV3 IGKV1 Kappa None None None None None 3zdz H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.75 X-RAY DIFFRACTION 0.2211 0.1844 False True IGHV14 IGKV14 Kappa None None None None None 6ikm J j 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 4yhy H L 0 IMMUNE SYSTEM 02/27/15 Crystal structure of 309M3-B in complex with trimethylated Lys HOMO SAPIENS homo sapiens homo sapiens Hattori, T., Dementieva, I.S., Montano, S.P., Koide, S. 1.9 X-RAY DIFFRACTION 0.242 0.206 False True IGHV3 IGLV3 Lambda None None None None None 7zf3 A B 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-3 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.15 X-RAY DIFFRACTION 0.266 0.208 False True IGHV3 IGKV3 Kappa None None None None None 4nhh E G 0 IMMUNE SYSTEM 11/05/13 Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 6.5 X-RAY DIFFRACTION 0.366 0.381 False True unknown IGKV1 Kappa None None None None None 1ors B A 0 C protein potassium channel MEMBRANE PROTEIN 03/14/03 X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab AEROPYRUM PERNIX; MUS MUSCULUS mus musculus mus musculus aeropyrum pernix Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. 1.9 X-RAY DIFFRACTION 0.251 0.231 False False IGHV3 IGKV4 Kappa None None None None None 5d1z B A 0 I protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT1 bound by clone D4-10 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN MSSA476) homo sapiens homo sapiens staphylococcus aureus (strain mssa476) Deng, X. 3.17 X-RAY DIFFRACTION 0.287 0.233 False True IGHV3 IGKV1 Kappa None None None None None 5i0z B NA 0 IMMUNE SYSTEM 02/04/16 Crystal structure of the single domain catalytic antibody 3D8-VH MUS MUSCULUS mus musculus Park, S.Y., Kim, J.S. 1.9 X-RAY DIFFRACTION 0.262 0.218 False True IGHV1 None None None None None 5cd3 C D 0 IMMUNE SYSTEM 07/02/15 Structure of immature VRC01-class antibody DRVIA7 HOMO SAPIENS homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.234 False True unknown IGKV1 Kappa None None None None None 3hns H L 0 H carbohydrate AXR polysaccharide IMMUNE SYSTEM 06/01/09 CS-35 Fab Complex with Oligoarabinofuranosyl Hexasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Murase, T., Zheng, R.B., Joe, M., Bai, Y., Marcus, S.L., Lowary, T.L., Ng, K.K.S. 2.0 X-RAY DIFFRACTION 0.217 0.170 False False IGHV1 IGKV10 Kappa None None None None None 4w6x B NA 0 A protein NA f18 fimbrial adhesin ac CELL ADHESION 08/21/14 Co-complex structure of the lectin domain of F18 fimbrial adhesin FedF with inhibitory nanobody NbFedF7 ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Moonens, K., De Kerpel, M., Coddens, A., Cox, E., Pardon, E., Remaut, H., De Greve, H. 1.88 X-RAY DIFFRACTION 0.226 0.186 False True IGHV1 NA NA None None None None None 6l62 H L 0 A protein capsid protein IMMUNE SYSTEM/VIRUS 10/25/19 Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope MUS MUSCULUS; PORCINE CIRCOVIRUS 2 mus musculus mus musculus porcine circovirus 2 Sun, Z., Huang, L., Xia, D., Wei, Y., Sun, E., Zhu, H., Bian, H., Wu, H., Feng, L., Wang, J., Liu, C. 7.2 ELECTRON MICROSCOPY False False IGHV1 IGKV6 Kappa None None None None None 7bem H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 scFv HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.52 X-RAY DIFFRACTION 0.247 0.217 False True IGHV3 IGKV1 Kappa None None None None None 7jx3 A B 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/26/20 Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Rosen, L.E., Nix, J.C., Corti, D., Veesler, D., Park, Y.J., Walls, A.C., Tortorici, M.A., Cameroni, E., Pinto, D., Beltramello, M. 2.65 X-RAY DIFFRACTION 0.288 0.258 False True IGHV1 IGKV3 Kappa None None None None None 7tpj H L 0 B protein NA putative cell surface polysaccharide polymerase/ligase MEMBRANE PROTEIN 01/25/22 Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its apo state CUPRIAVIDUS METALLIDURANS; HOMO SAPIENS homo sapiens homo sapiens cupriavidus metallidurans Ashraf, K.U., Nygaard, R., Vickery, O.N., Erramilli, S.K., Herrera, C.M., McConville, T.H., Petrou, V.I., Giacometti, S.I., Dufrisne, M.B., Nosol, K., Zinkle, A.P., Graham, C.L.B., Loukeris, M., Kloss, B., Skorupinska-Tudek, K., Swiezewska, E., Roper, D., Clarke, O.B., Uhlemann, A.C., Kossiakoff, A.A., Trent, M.S., Stansfeld, P.J., Mancia, F. 3.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4m3j A NA 0 IMMUNE SYSTEM 08/06/13 Structure of a single-domain camelid antibody fragment cAb-H7S specific of the BlaP beta-lactamase from Bacillus licheniformis LAMA GLAMA lama glama Pain, C., Kerff, F., Herman, R., Sauvage, E., Preumont, S., Charlier, P., Dumoulin, M. 1.95 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 None None None None None 7chb H L 0 R protein NA sars-cov-2 receptor binding domain ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Junyu, X., Qinyu, Z. 2.4 X-RAY DIFFRACTION 0.226 0.192 False True IGHV3 IGKV1 Kappa None None None None None 2pw2 B A 0 C peptide peptide epitope IMMUNE SYSTEM 05/10/07 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKWKSL HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.55 X-RAY DIFFRACTION 0.237 0.218 False False IGHV2 IGKV1 Kappa None None None None None 6ute A B 0 VIRAL PROTEIN 10/29/19 Crystal structure of Z032 Fab in complex with WNV EDIII HOMO SAPIENS; WEST NILE VIRUS homo sapiens homo sapiens Esswein, S.R., Gristick, H.B., Keeffe, J.R., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 5vsh E F 0 IMMUNE SYSTEM 05/11/17 CH1/Clambda Fab based on Pertuzumab HOMO SAPIENS homo sapiens homo sapiens Hendle, J. 2.55 X-RAY DIFFRACTION 0.255 0.207 False True IGHV3 IGKV1 Kappa None None None None None 5vjq G H 0 L protein lysozyme HYDROLASE/IMMUNE SYSTEM 04/19/17 Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I) MUS MUSCULUS; ANAS PLATYRHYNCHOS mus musculus mus musculus anas platyrhynchos Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.235 0.193 False True IGHV3 IGKV5 Kappa None None None None None 3t65 B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 07/28/11 S25-2- A(2-8)KDO disaccharide complex MUS MUSCULUS mus musculus mus musculus mus musculus Nguyen, H.P., Seto, N.O., Mackenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.45 X-RAY DIFFRACTION 0.211 0.193 False True IGHV7 IGKV8 Kappa None None None None None 7nx0 D NA 0 C protein NA leukocyte tyrosine kinase receptor PROTEIN BINDING 03/17/21 Extracellular TG and EGF-like domains of ALK HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens De Munck, S., Savvides, S.N. 1.95 X-RAY DIFFRACTION 0.196 0.169 False True IGHV1 NA NA None None None None None 4wfh E D 0 A protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a Tl+ bound nonconductive conformation MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 3.01 X-RAY DIFFRACTION 0.239 0.203 False True IGHV1 IGKV4 Kappa None None None None None 6nmv H L 0 S protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Non-Blocking Fab 218 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.61 X-RAY DIFFRACTION 0.301 0.195 False True IGHV3 unknown unknown None None None None None 7oxn H K 0 A peptide NA amyloid-beta precursor protein IMMUNE SYSTEM 06/22/21 Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Hall, G., Cowan, R., Carr, M.D. 2.5 X-RAY DIFFRACTION 0.265 0.228 False True IGHV2 IGKV10 Kappa None None None None None 5w23 I M 0 B protein fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 06/05/17 Crystal Structure of RSV F in complex with 5C4 Fab HUMAN RESPIRATORY SYNCYTIAL VIRUS A; MUS MUSCULUS mus musculus mus musculus human respiratory syncytial virus a Battles, M.B., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.239 0.198 False True IGHV14 IGKV3 Kappa None None None None None 1yc7 B NA 0 IMMUNE SYSTEM 12/22/04 cAbAn33 VHH fragment against VSG CAMELUS DROMEDARIUS camelus dromedarius Conrath, K., Vincke, C., Stijlemans, B., Schymkowitz, J., Wyns, L., Muyldermans, S., Loris, R. 1.6 X-RAY DIFFRACTION 0.212 0.192 False True IGHV1 None None None None None 5cjx D E 0 X | Y protein | protein NA | NA bg505 env gp41 | bg505 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 Crystal structure of 8ANC195 Fab in complex with BG505 SOSIP.664 HIV-1 Env trimer HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Scharf, L., Bjorkman, P.J. 3.584 X-RAY DIFFRACTION 0.286 0.239 False True unknown IGKV1 Kappa None None None None None 5cjq H L 0 B | A protein | protein NA | NA designed influenza hemagglutinin stem #4900, ha2 | designed influenza hemagglutinin stem #4900, ha1 VIRAL PROTEIN/IMMUNE SYSTEM 07/14/15 Crystal structure of a trimeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct | synthetic construct Zhu, X., Wilson, I.A. 3.6 X-RAY DIFFRACTION 0.369 0.346 False True IGHV1 IGLV1 Lambda 5e-10 -12.68887519701207 BLI TBD 2kh2 B b 5 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6ws6 C D 0 A Hapten JEF JEFFAMINE IMMUNE SYSTEM 05/27/20 Structural and functional analysis of a potent sarbecovirus neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., Marco, A.D., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Telenti, A., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 X-RAY DIFFRACTION 0.227 0.188 False True IGHV1 IGKV3 Kappa None None None None None 7rxc H L 0 B protein NA maltodextrin-binding protein,immunoglobulin g-bindingprotein a,immunoglobulin g-binding protein g STRUCTURAL PROTEIN 08/22/21 CryoEM structure of KDELR with Legobody MUS MUSCULUS; VICUGNA PACOS; ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS SP.; GALLUS GALLUS mus musculus mus musculus escherichia coli, staphylococcus aureus,streptococcus sp. Wu, X.D., Rapoport, T.A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV8 Kappa None None None None None 6os1 D NA 0 A protein type-1 angiotensin ii receptor,soluble cytochrome b562 brilfusion protein MEMBRANE PROTEIN 05/01/19 Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023 HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens, escherichia coli Wingler, L.M., Staus, D.P., Skiba, M.A., McMahon, C., Kleinhenz, A.L.W., Lefkowitz, R.J., Kruse, A.C. 2.794 X-RAY DIFFRACTION 0.282 0.239 False True IGHV1 None None None None None 3cfi I NA 0 H protein type ii secretory pathway, pseudopilin epsj PROTEIN TRANSPORT/Immune system 03/03/08 Nanobody-aided structure determination of the EPSI:EPSJ pseudopilin heterdimer from Vibrio Vulnificus VIBRIO VULNIFICUS; LAMA GLAMA lama glama vibrio vulnificus Lam, A.Y., Pardon, E., Korotkov, K.V., Steyaert, J., Hol, W.G.J. 2.58 X-RAY DIFFRACTION 0.279 0.229 False True IGHV3 None None None None None 1maj NA A 4 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7pnm G D 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/07/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 46C12 antibody Fab fragment HUMAN CORONAVIRUS OC43; HOMO SAPIENS homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7sob F E 0 D protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5d6c H L 0 L Hapten 57S 4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-5-O-phosphono-D-ribitol IMMUNE SYSTEM 08/12/15 Structure of 4497 Fab bound to synthetic wall teichoic acid fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lupardus, P.J., Fong, R. 1.72 X-RAY DIFFRACTION 0.238 0.203 False True IGHV3 IGKV4 Kappa None None None None None 2cju H L 0 H Hapten PHX 4-{[(Z)-(5-OXO-2-PHENYL-1,3-OXAZOL-4(5H)-YLIDENE)METHYL]AMINO}BUTANOIC ACID IMMUNE SYSTEM 04/09/06 Crystal structure of the TEPC15-Vk45.1 anti-2-phenyl-5-oxazolone NQ16- 113.8 scFv in complex with phOxGABA MUS MUSCULUS mus musculus mus musculus mus musculus Scotti, C., Gherardi, E. 2.5 X-RAY DIFFRACTION 0.291 0.241 False True IGHV7 IGKV1 Kappa None None None None None 2kh2 B b 63 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6zec H L 0 A carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 06/16/20 Crystal Structure of the Fab Fragment of a Glycosylated Lymphoma Antibody HOMO SAPIENS homo sapiens homo sapiens Allen, J.D., Watanabe, Y., Crispin, M., Bowden, T.A. 1.65 X-RAY DIFFRACTION 0.206 0.175 False True IGHV4 IGKV4 Kappa None None None None None 6xym A NA 0 NA NA NA NA IMMUNE SYSTEM 01/30/20 Nbe-LBM LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.2 X-RAY DIFFRACTION 0.198 0.154 False True IGHV1 NA NA None None None None None 3nz8 A B 0 IMMUNE SYSTEM 07/16/10 Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 MUS MUSCULUS mus musculus mus musculus Uchtenhagen, H, Friemann, R, Raszewski, G, Spetz, A-L, Nilsson, L, Achour, A 2.7 X-RAY DIFFRACTION 0.273 0.226 False True IGHV1 IGKV1 Kappa None None None None None 7pnq X Y 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/07/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 43E6 antibody Fab fragment HOMO SAPIENS; HUMAN CORONAVIRUS OC43 homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7we8 H L 0 A | C | B protein | protein | protein NA | NA | NA spike glycoprotein | spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV2 Lambda None None None None None 1lhz NA A 0 IMMUNE SYSTEM 04/17/02 Structure of a Human Bence-Jones Dimer Crystallized in U.S. Space Shuttle Mission STS-95: 293K HOMO SAPIENS homo sapiens Terzyan, S.S., DeWitt, C.R., Ramsland, P.A., Bourne, P.C., Edmundson, A.B. 2.3 X-RAY DIFFRACTION 0.226 0.173 False False IGLV2 Lambda None None None None None 1lil NA B 0 IMMUNOGLOBULIN 05/13/96 BENCE JONES PROTEIN CLE, A LAMBDA III IMMUNOGLOBULIN LIGHT-CHAIN DIMER HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.65 X-RAY DIFFRACTION 0.340 0.190 False False IGLV3 Lambda None None None None None 7cak G F 0 B protein NA spike glycoprotein VIRAL PROTEIN 06/08/20 SARS-CoV-2 S trimer with three RBD in the open state and complexed with three H014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 5iv2 D C 0 IMMUNE SYSTEM 03/18/16 Cetuximab Fab in complex with Arg9Cir meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.481 X-RAY DIFFRACTION 0.211 0.165 False True IGHV2 IGKV5 Kappa None None None None None 6mnf H L 0 IMMUNE SYSTEM 10/01/18 Anti-HIV-1 Fab 2G12 + Man8 re-refinement HOMO SAPIENS homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 2.758 X-RAY DIFFRACTION 0.252 0.218 False True unknown IGKV1 Kappa 1.3e-06 -8.030017991549332 Unknown TBD 6n5d L N 0 K protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/21/18 Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Bajic, G., Schmidt, A.G. 3.0 X-RAY DIFFRACTION 0.244 0.217 False True IGHV5 IGLV1 Lambda None None None None None 7bud H L 0 A | C protein | protein NA | NA dengue virus serotype 2 e protein | dengue virus serotype 2 e protein VIRUS 04/06/20 Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 8.0 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 | dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7k9j H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/20 SARS-CoV-2 Spike in complex with neutralizing Fab 2H04 (three down conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Errico, J.M., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 6vlr F N 0 I | B protein | protein NA | NA bg505 sosipv5.2 gp41 | bg505 sosipv5.2 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/24/20 BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 4.42 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV2 Kappa None None None None None 6vmk r q 0 s protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False False IGHV1 IGKV1 Kappa None None None None None 5u4m B NA 0 A protein ricin HYDROLASE/IMMUNE SYSTEM 12/05/16 RTA-V1C7-G29R-no_salt RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Mantis, N. 2.5 X-RAY DIFFRACTION 0.247 0.202 False True IGHV1 3.9000000000000005e-10 -12.836084497507047 SPR TBD 6xul G I 0 NA NA NA NA ANTITUMOR PROTEIN 01/20/20 Apo Ab 5b1 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.230 0.168 False True IGHV3 IGLV1 Lambda None None None None None 4gaj H L 0 P peptide genome polyprotein IMMUNE SYSTEM 07/25/12 Structure of the broadly neutralizing antibody AP33 in complex with its HCV epitope (E2 residues 411-424) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Potter, J.A., Owsianka, A., Taylor, G.L, Patel, A.H. 2.51 X-RAY DIFFRACTION 0.320 0.240 False False IGHV3 IGKV3 Kappa None None None None None 7u8m K J 0 I protein NA hemagglutinin ha2 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 5.39 X-RAY DIFFRACTION 0.342 0.304 False True IGHV3 IGKV3 Kappa None None None None None 5o7p B A 0 C protein receptor tyrosine-protein kinase erbb-3 IMMUNE SYSTEM 06/09/17 HER3 in complex with Fab MF3178 HOMO SAPIENS homo sapiens homo sapiens homo sapiens De Nardis, C., Gros, P. 4.5 X-RAY DIFFRACTION 0.296 0.247 False True IGHV1 IGKV1 Kappa None None None None None 7chh G H 0 B protein NA spike glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with BD-368-2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J., Zhu, Q., Wang, G. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7bep A B 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-384 and S309 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.61 X-RAY DIFFRACTION 0.241 0.203 False True IGHV3 IGKV1 Kappa None None None None None 6pcu C B 0 A protein outer capsid protein vp4 viral protein/immune system 06/18/19 VP8* of a G2P[4] human rotavirus in complex with scFv antibody 9 ROTAVIRUS A; HOMO SAPIENS homo sapiens homo sapiens rotavirus a Hu, L., Venkataram Prasad, B.V. 2.4 X-RAY DIFFRACTION 0.237 0.186 False True IGHV4 IGLV9 Lambda None None None None None 6sm1 NA A 0 IMMUNE SYSTEM 08/21/19 Wild type immunoglobulin light chain (WT-1) HOMO SAPIENS homo sapiens Kazman, P., Vielberg, M.-T., Cendales, M.D.P., Hunziger, L., Weber, B., Hegenbart, U., Zacharias, M., Koehler, R., Schoenland, S., Groll, M., Buchner, J. 1.55 X-RAY DIFFRACTION 0.165 0.142 False True IGLV2 Lambda None None None None None 2r6p D E 0 A protein major envelope protein e Virus/Immune System 09/06/07 Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus. DENGUE VIRUS 2 PUERTO RICO/PR159-S1/1969; MUS MUSCULUS mus musculus mus musculus dengue virus 2 puerto rico/pr159-s1/1969 Lok, S.M., Kostyuchenko, V.K., Holdaway, H.A., Chipman, P.R., Kuhn, R.J, Rossmann, M.G 24 ELECTRON MICROSCOPY False True IGHV14 IGKV3 Kappa None None None None None 3chn C O 4 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7t4r G H 0 B protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11 HOMO SAPIENS; HUMAN BETAHERPESVIRUS 5 homo sapiens homo sapiens human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 1ken H L 0 A protein hemagglutinin ha1 Viral protein/Immune system 11/16/01 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Barbey-Martin, C., Gigant, B., Bizebard, T., Calder, L.J., Wharto, S.A., Skehel, J.J., Knossow, M. 3.5 X-RAY DIFFRACTION 0.323 0.255 False False IGHV3 IGKV4 Kappa None None None None None 6h7l C NA 0 A protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.7 X-RAY DIFFRACTION 0.278 0.241 False True IGHV1 None None None None None 2nlj B A 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 10/20/06 Potassium Channel KcsA(M96V)-Fab complex in KCl STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Lockless, S.W., Zhou, M., MacKinnon, R. 2.52 X-RAY DIFFRACTION 0.255 0.235 False False IGHV1 IGKV5 Kappa None None None None None 3cm9 C N 9 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6wps H L 0 A protein sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/27/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., De Marco, A., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6n4y H NA 0 C protein metabotropic glutamate receptor 5 MEMBRANE PROTEIN 11/20/18 Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K. 3.262 X-RAY DIFFRACTION 0.251 0.199 False True IGHV1 None None None None None 6ymq E e 0 0 protein NA unknown IMMUNE SYSTEM 04/09/20 TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) HOMO SAPIENS homo sapiens Szykowska, A., Preger, C., Scacioc, A., Mukhopadhyay, S.M.M., McKinley, G., Graslund, S., Wigren, E., Persson, H., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Di Daniel, E., Davis, J.B., Burgess-Brown, N., Bullock, A. 3.07 X-RAY DIFFRACTION 0.288 0.274 True True unknown unknown unknown None None None None None 5e1h B NA 0 A protein ricin TOXIN/IMMUNE SYSTEM 09/29/15 Ricin toxin in complex with neutralizing single chain monoclonal antibodies (VHHs) CAMELIDAE; RICINUS COMMUNIS camelidae ricinus communis Rudolph, M.J., Vance, D., Shoemaker, C., Mantis, N. 2.032 X-RAY DIFFRACTION 0.257 0.204 False True IGHV1 None None None None None 3fct B A 0 IMMUNE SYSTEM 06/13/99 MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN HOMO SAPIENS homo sapiens homo sapiens Romesberg, F.E., Santarsiero, B.D., Barnes, D., Yin, J., Spiller, B., Schultz, P.G., Stevens, R.C. 2.4 X-RAY DIFFRACTION 0.293 0.206 False True IGHV1 IGKV6 Kappa None None None None None 3mcl H L 0 IMMUNE SYSTEM 03/29/10 Anti-beta-amyloid antibody c706 fab in space group P21 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.7 X-RAY DIFFRACTION 0.260 0.203 False True IGHV1 IGKV4 Kappa None None None None None 5lmw A NA 0 IMMUNE SYSTEM 08/01/16 Llama nanobody PorM_02 LAMA GLAMA lama glama Roche, J., Gaubert, A., Leone, P., Roussel, A. 1.5 X-RAY DIFFRACTION 0.196 0.188 False True IGHV1 None None None None None 7t4q I H 0 D | B protein | protein NA | NA envelope glycoprotein ul130 | envelope glycoprotein l VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with neutralizing fabs 2C12, 7I13 and 13H11 HUMAN BETAHERPESVIRUS 5; HOMO SAPIENS homo sapiens homo sapiens human betaherpesvirus 5 | human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6apd D E 0 A protein fusion glycoprotein f0,envelope glycoprotein IMMUNE SYSTEM 08/17/17 Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 RESPIRATORY SYNCYTIAL VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus, humanimmunodeficiency virus 1 Wrapp, D., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.256 0.204 False True IGHV1 IGKV3 Kappa None None None None None 7b18 E NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/24/20 SARS-CoV-spike bound to two neutralising nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7sfx A B 0 E peptide NA cd99 antigen peptide IMMUNE SYSTEM 10/04/21 10A1 Fab in complex with CD99 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Romero, L.A., Hattori, T., Koide, S. 3.1 X-RAY DIFFRACTION 0.248 0.226 False True IGHV6 IGLV3 Lambda None None None None None 4tnw X i 0 S protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False unknown unknown unknown None None None None None 6fbj H L 0 METAL BINDING PROTEIN 12/19/17 monoclonal antibody targeting Matrix metalloproteinase 7 ESCHERICHIA COLI K-12 escherichia coli k-12 escherichia coli k-12 Dym, O. 2.3 X-RAY DIFFRACTION 0.249 0.207 False True IGHV1 IGKV3 Kappa None None None None None 3drt B A 0 C peptide scrhyb3k construct IMMUNE SYSTEM 07/11/08 Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 scrambledFP-MPER scrHyb3K construct GIGAFGLLGFLAAGSKK-Ahx-K656NEQELLELDKWASLWN671 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., de la Torre, B.G., Andreu, D., Nieva, J.L., Pai, E.F. 3.3 X-RAY DIFFRACTION 0.229 0.203 False True IGHV2 IGKV1 Kappa None None None None None 7jks H L 0 G protein NA hiv-1 gp120 core IMMUNE SYSTEM 07/28/20 Crystal structure of vaccine-elicited broadly neutralizing VRC01-class antibody 2411a in complex with HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Zhou, T., Chen, X., Kwong, P.D., Mascola, J.R. 3.45 X-RAY DIFFRACTION 0.332 0.283 False True IGHV1 IGKV3 Kappa None None None None None 1vhp A NA 16 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4nry H L 0 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66 HOMO SAPIENS homo sapiens homo sapiens Ofek, G., Yang, Y., Kwong, P.D. 3.14 X-RAY DIFFRACTION 0.256 0.228 False True IGHV5 IGKV1 Kappa None None None None None 6foe H L 0 IMMUNE SYSTEM 02/07/18 BaxB01 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Hollerweger, J., Schinagl, A., Kerschbaumer, R.J., Scheiflinger, F., Thiele, M., Goettig, P., Brandstetter, H. 2.6 X-RAY DIFFRACTION 0.263 0.214 False True IGHV3 IGKV1 Kappa None None None None None 7lxz G I 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2L28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6v4o C G 0 M protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 2E01 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7kba A B 0 NA NA NA NA ANTIVIRAL PROTEIN, IMMUNE SYSTEM 10/01/20 Crystal structure of the HCMV pentamer-specific Fab 2-18 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., McLellan, J.S. 2.8 X-RAY DIFFRACTION 0.257 0.222 False True IGHV3 IGKV1 Kappa None None None None None 5ibu G B 0 IMMUNE SYSTEM 02/22/16 6652 Fab (unbound) HOMO SAPIENS homo sapiens homo sapiens Raymond, D.D., Harrison, S.C. 1.71 X-RAY DIFFRACTION 0.245 0.210 False True IGHV5 IGKV3 Kappa None None None None None 6niu F G 0 B protein envelope protein e Viral protein/IMMUNE SYSTEM 12/31/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 in complex with ZIKV E glycoprotein HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 4.303 X-RAY DIFFRACTION 0.359 0.264 False True IGHV4 IGLV1 Lambda None None None None None 4i2x B A 0 E protein signal-regulatory protein gamma IMMUNE SYSTEM 11/23/12 Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nettleship, J.E., Ren, J., Stuart, D.I., Owens, R.J., Oxford Protein Production Facility (OPPF) 2.48 X-RAY DIFFRACTION 0.260 0.196 False False IGHV1 IGKV6 Kappa 1.2e-06 -8.077441989548914 AUC TBD 7kfv C D 0 B protein NA surface glycoprotein IMMUNE SYSTEM/Viral protein 10/15/20 Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B12 Fab) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Clark, L., Clark, S. 2.102 X-RAY DIFFRACTION 0.216 0.183 False True IGHV3 IGKV1 Kappa None None None None None 4b41 A NA 0 IMMUNE SYSTEM 07/27/12 Crystal structure of an amyloid-beta binding single chain antibody G7 LAMA GLAMA lama glama Beringer, D.X., Dorresteijn, B., Rutten, L., Wienk, H., el Khattabi, M., Kroon-Batenburg, L.M.J., Verrips, C.T. 1.191 X-RAY DIFFRACTION 0.1619 0.1360 False True IGHV1 None None None None None 7r4i E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/08/22 The SARS-CoV-2 spike in complex with the 2.15 neutralizing nanobody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Casasnovas, J.M., Melero, R., Arranz, R., Fernandez, L.A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3r06 F E 0 IMMUNE SYSTEM 03/07/11 Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius Shore, D.A., Zhu, X., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.191 False True IGHV5 IGKV14 Kappa None None None None None 6cm3 T U 0 C protein envelope glycoprotein gp160 VIRAL PROTEIN 03/02/18 BG505 SOSIP in complex with sCD4, 17b, 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 3.54 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7m1h F NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/13/21 Crystal structure of LC/A-JPU-C10-JPU-D12-JPU-B8-JPU-G3-ciA-F12-ciA-D12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.78 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 NA NA None None None None None 1a8j NA H 0 L Hapten PME N-L-ALPHA-ASPARTYL L-PHENYLALANINE 1-METHYL ESTER IMMUNOGLOBULIN 03/26/98 IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME HOMO SAPIENS homo sapiens homo sapiens Edmundson, A.B., Manion, C.V. 2.7 X-RAY DIFFRACTION 0.380 0.220 False False IGLV2 Lambda None None None None None 6bfq C D 0 G protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 10/26/17 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W. 2.6 X-RAY DIFFRACTION 0.264 0.230 False True IGHV4 IGKV1 Kappa None None None None None 7niv C B 0 A protein NA isoform 2 of phosphatidylcholine translocator abcb4 PROTEIN TRANSPORT 02/14/21 Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nosol, K., Locher, K.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5gzr H L 0 VIRUS 10/01/16 Zika virus E protein complexed with a neutralizing antibody Z23-Fab HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens Gao, G.G., Shi, Y., Peng, R., Liu, S. 9.4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6sne F E 0 N peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.9 X-RAY DIFFRACTION 0.261 0.218 False True IGHV4 IGKV1 Kappa None None None None None 1u8k B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LELDKWASL HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.246 0.215 False False IGHV2 IGKV1 Kappa None None None None None 4hg4 V W 0 G protein hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 7zfa E F 0 B protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV4 IGKV1 Kappa None None None None None 7d0c G F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-3A1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, R.K., Yu, J.F., Zhang, Y.Y., Liu, N., Wang, H.W., Wang, X.Q., Zhang, L.Q., Zhou, Q. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 2osl A B 0 Q peptide b-lymphocyte antigen cd20 Immune System 02/06/07 Crystal structure of Rituximab Fab in complex with an epitope peptide HOMO SAPIENS, MUS MUSCULUS; SYNTHETIC CONSTRUCT homo sapiens, mus musculus homo sapiens, mus musculus Du, J., Zhong, C., Ding, J. 2.6 X-RAY DIFFRACTION 0.296 0.239 False True IGHV1 IGKV4 Kappa None None None None None 5ucb H L 0 B protein histone chaperone asf1 IMMUNE SYSTEM 12/22/16 Structure of antigen-Fab complex with engineered switch residue region. HOMO SAPIENS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C) homo sapiens homo sapiens saccharomyces cerevisiae (strain atcc 204508 /s288c) Bailey, L.J., Kossiakoff, A.A., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS) 1.521 X-RAY DIFFRACTION 0.169 0.138 False True IGHV3 IGKV1 Kappa None None None None None 3o45 H L 0 P peptide fusion glycoprotein f1 IMMUNE SYSTEM/VIRAL PROTEIN 07/26/10 Crystal Structure of 101F Fab Bound to 17-mer Peptide Epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus McLellan, J.S., Chen, M., Chang, J.S., Yang, Y., Kim, A., Graham, B.S., Kwong, P.D. 2.872 X-RAY DIFFRACTION 0.254 0.200 False True IGHV8 IGKV3 Kappa None None None None None 5nm0 D NA 0 IMMUNE SYSTEM 04/05/17 Nb36 Ser85Cys with Hg, crystal form 1 LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 1.5 X-RAY DIFFRACTION 0.211 0.189 False True IGHV1 None None None None None 4ydl H L 0 G protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 02/22/15 Crystal structure of broadly and potently neutralizing antibody C38-VRC18.02 in complex with HIV-1 clade AE strain 93TH057gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.207 0.174 False True unknown IGKV3 Kappa None None None None None 2uud H L 0 S peptide nq10-1.12 anti-phox antibody IMMUNE SYSTEM 03/02/07 Crystal structure of the TEPC15-Vk45.1 anti-2-phenyl-5-oxazolone NQ10- 1.12 scFv in complex with the hapten MUS MUSCULUS mus musculus mus musculus mus musculus Scotti, C., Gherardi, E. 2.9 X-RAY DIFFRACTION 0.297 0.228 False True IGHV7 IGKV1 Kappa None None None None None 7mlv H I 0 C protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7bc6 B NA 0 A protein NA proton-coupled folate transporter MEMBRANE PROTEIN 12/18/20 Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5 GALLUS GALLUS; LAMA GLAMA lama glama gallus gallus Parker, J.L., Deme, J.C., Lea, S.M., Newstead, S. 3.2 ELECTRON MICROSCOPY NA NA False False IGHV3 NA NA None None None None None 7k8n A B 0 NA NA NA NA IMMUNE SYSTEM 09/27/20 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C102 HOMO SAPIENS homo sapiens homo sapiens Jette, C.A., Barnes, C.O., Bjorkman, P.J. 1.65 X-RAY DIFFRACTION 0.207 0.197 False True IGHV3 IGKV3 Kappa None None None None None 4org C D 0 IMMUNE SYSTEM 02/11/14 Crystal structure of human Fab CAP256-VRC26.04, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 3.121 X-RAY DIFFRACTION 0.289 0.275 False True IGHV3 IGLV1 Lambda None None None None None 3wii H L 0 IMMUNE SYSTEM 09/12/13 Crystal structure of the Fab fragment of B2212A, a murine monoclonal antibody specific for the third fibronectin domain (Fn3) of human ROBO1. MUS MUSCULUS mus musculus mus musculus Nakayama, T., Mizohata, E., Yamashita, T., Nagatoishi, S., Nakakido, M., Iwanari, H., Mochizuki, Y., Kado, Y., Yokota, Y., Sato, R., Tsumoto, K., Fujitani, H., Kodama, T., Hamakubo, T., Inoue, T. 1.6 X-RAY DIFFRACTION 0.230 0.185 False False IGHV1 IGKV10 Kappa None None None None None 7dw9 S s 0 A protein NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 01/15/21 Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Zhou, F., Jiang, Y. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7m7j C D 0 A protein NA eryai BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: ""turnstile closed"" state (TE-free) SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 4uta H L 0 B protein envelope glycoprotein e IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Rouvinski, A., Guardado-Calvo, P., Barba-Spaeth, G., Duquerroy, S., Vaney, M.C., Rey, F.A. 3.0 X-RAY DIFFRACTION 0.2477 0.2128 False True IGHV3 IGKV3 Kappa None None None None None 5yoy I F 0 A protein tumor necrosis factor IMMUNE SYSTEM 10/31/17 Crystal structure of the human tumor necrosis factor in complex with golimumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N. 2.727 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV3 Kappa 1.8e-11 -14.658430977236662 Unknown TBD 7lxz F C 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2L28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5vpl D C 0 A protein der f 1 variant HYDROLASE/IMMUNE SYSTEM 05/05/17 CRYSTAL STRUCTURE OF DER F 1 COMPLEXED WITH FAB 4C1 MUS MUSCULUS; DERMATOPHAGOIDES FARINAE mus musculus mus musculus dermatophagoides farinae Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W. 1.9 X-RAY DIFFRACTION 0.194 0.152 False True IGHV3 IGKV14 Kappa 1.7e-08 -10.599564136380756 ITC TBD 7wq4 N NA 0 A | B protein | protein NA | NA engineered guanine nucleotide-binding protein g(q) subunitalpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/24/22 Galanin-bound galanin receptor 2 in complex with Gq HOMO SAPIENS; RATTUS; LAMA GLAMA; BOS TAURUS; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus Duan, J., Shen, D.D., Xu, H.E., Zhang, Y., Jiang, Y. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6yxg H h 0 A protein NA adiponectin receptor protein 2 MEMBRANE PROTEIN 05/01/20 Cryogenic human adiponectin receptor 2 (ADIPOR2) with Tb-XO4 ligand determined by Serial Crystallography (SSX) using CrystalDirect HOMO SAPIENS homo sapiens homo sapiens Healey, R.D., Basu, S., Humm, A.S., Leyrat, C., Dupeux, F., Pica, A., Granier, S., Marquez, J.A. 3.01 X-RAY DIFFRACTION 0.252 0.213 True True unknown unknown unknown None None None None None 7f1o E NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/09/21 Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex with Nb35 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Xiao, T., Zheng, S. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6oz6 G NA 0 C protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to 3'-hydroxymureidomycin A LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.7 X-RAY DIFFRACTION 0.301 0.257 False True IGHV1 None None None None None 7lf0 D E 0 B protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7om5 A NA 0 NA NA NA NA IMMUNE SYSTEM 05/21/21 Anti-EGFR nanobody EgB4 LAMA GLAMA lama glama Zeronian, M.R., Janssen, B.J.C. 1.48 X-RAY DIFFRACTION 0.205 0.177 False True IGHV1 NA NA None None None None None 6aj9 D E 0 A protein NA capsid protein vp1 VIRUS 08/27/18 The structure of Enterovirus D68 mature virion in complex with Fab 15C5 and 11G1 MUS MUSCULUS; ENTEROVIRUS D68 mus musculus mus musculus enterovirus d68 Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 6gjs C NA 0 A protein cystic fibrosis transmembrane conductance regulator IMMUNE SYSTEM 05/16/18 Human NBD1 of CFTR in complex with nanobodies D12 and T4 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 1.95 X-RAY DIFFRACTION 0.212 0.177 False True IGHV1 None None None None None 7zmm K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.5 X-RAY DIFFRACTION 0.281 0.240 False True IGHV1 NA NA None None None None None 4fqk E F 0 C protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dreyfus, C., Laursen, N.S., Wilson, I.A. 5.65 X-RAY DIFFRACTION 0.324 0.306 False True IGHV1 IGLV1 Lambda None None None None None 3bjl NA B 0 IMMUNOGLOBULIN 05/26/95 LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.3 X-RAY DIFFRACTION unknown unknown False False IGLV1 Lambda None None None None None 7cj2 C D 0 A protein NA chitinase 3-like 1 (cartilage glycoprotein-39), isoformcra_a IMMUNE SYSTEM 07/09/20 Crystal structure of the Fab antibody complexed with human YKL-40 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Choi, S., Na, J.H., Lee, S.J., Woo, J.R., Kim, D.Y., Hong, J.T., Lee, W.K. 2.7 X-RAY DIFFRACTION 0.269 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6nmr J K 0 M protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.42 X-RAY DIFFRACTION 0.323 0.289 False True IGHV3 IGKV3 Kappa None None None None None 4yga F NA 0 E protein calmodulin-domain protein kinase 1 METAL BINDING PROTEIN 02/26/15 CDPK1, from Toxoplasma gondii, bound to inhibitory VHH-1B7 VICUGNA PACOS; TOXOPLASMA GONDII vicugna pacos toxoplasma gondii Knockenhauer, K.E., Schwartz, T.U. 2.94 X-RAY DIFFRACTION 0.262 0.226 False True IGHV1 None None None None None 4unt NA G 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 7q6e E F 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/07/21 Beta049 fab in complex with SARS-CoV2 beta-Spike glycoprotein, The Beta mAb response underscores the antigenic distance to other SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1fl5 H L 0 IMMUNE SYSTEM 08/11/00 THE UNLIGANDED GERMLINE PRECURSOR TO THE SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4. MUS MUSCULUS; HOMO SAPIENS homo sapiens mus musculus Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G. 2.1 X-RAY DIFFRACTION 0.268 0.226 False True IGHV7 IGKV1 Kappa None None None None None 6nnj H L 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 01/15/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to CH31 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.1 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.6 X-RAY DIFFRACTION 0.293 0.248 False True IGHV4 unknown unknown None None None None None 6bf7 C D 0 A protein insulin-degrading enzyme HYDROLASE/IMMUNE SYSTEM 10/26/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 6.5 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 5itf B A 0 IMMUNE SYSTEM 03/16/16 Cetuximab Fab in complex with 2-bromophenylalanine meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.51 X-RAY DIFFRACTION 0.223 0.184 False True IGHV2 IGKV5 Kappa 1.8e-06 -7.837210530185391 Unknown TBD 5tru h l 0 c protein unknown IMMUNE SYSTEM 10/27/16 Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ramagopal, U.A., Liu, W., Garrett-Thomson, S.C., Yan, Q., Srinivasan, M., Wong, S.C., Bell, A., Mankikar, S., Rangan, V.S., Deshpande, S., Bonanno, J.B., Korman, A.J., Almo, S.C. 3.0 X-RAY DIFFRACTION 0.268 0.204 False False IGHV3 IGKV3 Kappa 1.06e-08 -10.87942933816716 Unknown TBD 3fzu C D 0 IMMUNE SYSTEM 01/26/09 IgG1 Fab characterized by H/D exchange HOMO SAPIENS homo sapiens homo sapiens Arndt, J., Houde, D., Domeier, W., Berkowitz, S., Engen, J.R. 2.5 X-RAY DIFFRACTION 0.261 0.210 False True IGHV3 IGKV1 Kappa None None None None None 2kqm NA A 12 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7whi E NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 2 complex structure of Omicron spike with Bn03 (2-up RBD, 4 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7bsd A B 0 G protein NA ns1c IMMUNE SYSTEM/VIRAL PROTEIN 03/30/20 Complex structure of 1G5.3 Fab bound to ZIKV NS1c HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Song, H., Qi, J., Gao, F.G. 2.53 X-RAY DIFFRACTION 0.239 0.221 False True IGHV3 IGKV3 Kappa None None None None None 3fo2 H L 0 H Hapten BZH 5-[(2-AMINO-1H-BENZIMIDAZOL-6-YL)AMINO]-5-OXOPENTANOIC ACID IMMUNE SYSTEM 12/27/08 Crystal structure of hapten complex of catalytic elimination antibody 13G5 (Glu(L39)Gln mutant) MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.18 X-RAY DIFFRACTION 0.256 0.201 False True IGHV2 IGKV1 Kappa None None None None None 6niu M N 0 E protein envelope protein e Viral protein/IMMUNE SYSTEM 12/31/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 in complex with ZIKV E glycoprotein HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 4.303 X-RAY DIFFRACTION 0.359 0.264 False True IGHV4 IGLV1 Lambda None None None None None 6ocb H L 0 A protein hemagglutinin IMMUNE SYSTEM 03/22/19 Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/1968) HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Wilson, I.A., Lang, S. 2.1 X-RAY DIFFRACTION 0.239 0.202 False True IGHV4 IGKV1 Kappa None None None None None 7ps0 B C 0 A protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with beta-24 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.92 X-RAY DIFFRACTION 0.271 0.222 False True IGHV4 IGLV2 Lambda None None None None None 6bfq A B 0 I protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 10/26/17 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W. 2.6 X-RAY DIFFRACTION 0.264 0.230 False True IGHV4 IGKV1 Kappa None None None None None 1k6q H L 0 IMMUNE SYSTEM 10/17/01 Crystal structure of antibody Fab fragment D3 MUS MUSCULUS mus musculus mus musculus Faelber, K., Kelley, R.F., Kirchhofer, D., Muller, Y.A. 2.4 X-RAY DIFFRACTION 0.298 0.225 False True IGHV14 IGKV14 Kappa None None None None None 3duu D C 0 D carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/17/08 Crystal structure of SAG506-01, orthorhombic, twinned, crystal 2 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.217 0.194 False True IGHV7 IGKV8 Kappa None None None None None 3wd5 H L 0 A protein tumor necrosis factor IMMUNE SYSTEM 06/06/13 Crystal structure of TNFalpha in complex with Adalimumab Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hu, S., Liang, S.Y., Guo, Y.J., Lou, Z.Y. 3.101 X-RAY DIFFRACTION 0.275 0.187 False True IGHV3 IGKV1 Kappa 1.1500000000000002e-10 -13.559634224160162 SPR TBD 7nil F NA 0 A protein NA polymerase acidic protein VIRAL PROTEIN 02/12/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); STAPHYLOCOCCUS AUREUS; CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (a/brevigmission/1/1918(h1n1)) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 5.01 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7ndf D NA 0 A protein NA lipid a abc transporter atp-binding protein/permease msba PROTEIN BINDING 02/01/21 Crystal structure of nanobody Nb_MsbA#1 in complex with the nucleotide binding domain of MsbA VICUGNA PACOS; ESCHERICHIA COLI vicugna pacos escherichia coli Meier, G., Seeger, M. 2.1 X-RAY DIFFRACTION 0.244 0.205 False True IGHV1 NA NA None None None None None 6d01 E F 0 J peptide nanp5 IMMUNE SYSTEM 04/09/18 Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Imkeller, K., Wardemann, H., Julien, J.P. 3.2 X-RAY DIFFRACTION 0.227 0.204 False True IGHV3 IGKV1 Kappa 2.86e-07 -8.927113962567878 Unknown TBD 4ocl F NA 0 E | D protein | protein NA | NA 26s proteasome regulatory subunit rpn11 | 26s proteasome regulatory subunit rpn8 HYDROLASE, PROTEIN BINDING 01/09/14 Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form Ia SACCHAROMYCES CEREVISIAE; LAMA GLAMA lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Pathare, G.R., Bracher, A. 2.4 X-RAY DIFFRACTION 0.252 0.195 False True IGHV1 NA NA None None None None None 7nx7 A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the K417N mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.3 X-RAY DIFFRACTION 0.239 0.208 False True IGHV3 IGKV3 Kappa None None None None None 6s8j P O 0 C protein envelope glycoprotein 1 VIRAL PROTEIN 07/10/19 Structure of ZEBOV GP in complex with 5T0180 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 2.91 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7r1z E NA 0 A protein NA activity-regulated cytoskeleton-associated protein SIGNALING PROTEIN 02/03/22 C-terminal domain of hArc in complex with nanobodies H11 and C11, collapsed crystal form VICUGNA PACOS; RATTUS NORVEGICUS vicugna pacos rattus norvegicus Markusson, S., Kursula, P. 1.94 X-RAY DIFFRACTION 0.243 0.197 False True IGHV1 NA NA None None None None None 6ca6 B A 0 IMMUNE SYSTEM 01/29/18 Crystal structure of PCT64_35S, a broadly neutralizing anti-HIV antibody. HOMO SAPIENS homo sapiens homo sapiens Murrell, S., Wilson, I.A. 2.43 X-RAY DIFFRACTION 0.245 0.201 False True IGHV3 IGKV3 Kappa None None None None None 7mbx N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN/SIGNALING PROTEIN 04/01/21 Human Cholecystokinin 1 receptor (CCK1R) Gs complex HOMO SAPIENS; RATTUS NORVEGICUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus norvegicus | homo sapiens Mobbs, J.I., Belousoff, M.J., Danev, R., Thal, D.M., Sexton, P.M. 1.95 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6uda G H 0 E protein ch505.n279k.g458y.sosip.664 gp120 VIRAL PROTEIN/Immune System 09/19/19 Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 2eh8 H L 0 P peptide pres1/pres2/surface protein IMMUNE SYSTEM 03/05/07 Crystal structure of the complex of humanized KR127 fab and PRES1 peptide epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Chi, S.-W., Kim, S.-J., Maeng, C.-Y., Hong, H.J., Ryu, S.-E. 2.6 X-RAY DIFFRACTION 0.258 0.193 False True IGHV1 IGKV1 Kappa 1.10e-08 -11.29 Other 37 17517649 7n28 C D 0 A protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/28/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Gao, F. 4.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5tqa A B 0 IMMUNE SYSTEM 10/23/16 Crystal Structure of DH270.6 (unliganded) from the DH270 Broadly Neutralizing N332-Glycan Dependent Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.723 X-RAY DIFFRACTION 0.201 0.185 False True IGHV1 IGLV2 Lambda None None None None None 5wk2 H L 0 IMMUNE SYSTEM 07/24/17 CRYSTAL STRUCTURE OF ANTI-CCL17 ANTIBODY M116 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.5 X-RAY DIFFRACTION 0.208 0.180 False True IGHV5 IGKV4 Kappa None None None None None 4ios G NA 0 B protein NA bpp VIRAL PROTEIN 01/08/13 Structure of phage TP901-1 RBP (ORF49) in complex with nanobody 11. LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 Desmyter, A., Farenc, C., Mahony, J., Spinelli, S., Bebeacua, C., Blangy, S., Veesler, D., van Sinderen, D., Cambillau, C. 2.4 X-RAY DIFFRACTION 0.227 0.201 False True IGHV1 NA NA None None None None None 6vmk K J 0 N protein NA fab y49r light chain HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 6k5f E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/28/19 Crystal structure of the CLC-ec1 deltaNC in presence of 200 mM NaBr ESCHERICHIA COLI; MUS MUSCULUS mus musculus escherichia coli Park, K., Lim, H.H. 3.203 X-RAY DIFFRACTION 0.300 0.236 False True IGHV4 IGKV4 Kappa None None None None None 6pz8 D K 0 F protein s protein VIRAL PROTEIN/IMMUNE SYSTEM 07/31/19 MERS S0 trimer in complex with variable domain of antibody G2 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Bowman, C.A., Pallesen, J., Ward, A.B. 4.19 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 1eeq NA B 0 IMMUNE SYSTEM 02/01/00 M4L/Y(27D)D/T94H Mutant of LEN HOMO SAPIENS homo sapiens Pokkuluri, P.R., Raffen, R., Dieckman, L., Boogaard, C., Stevens, F.J., Schiffer, M. 1.5 X-RAY DIFFRACTION 0.238 0.211 False True IGKV4 Kappa None None None None None 7rlz A B 0 P peptide NA peptide from circumsporozoite protein variant vk210 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRAAGQPAGNGAGGQAA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.27 X-RAY DIFFRACTION 0.239 0.191 False True IGHV1 IGKV1 Kappa None None None None None 1i7z D C 0 C Hapten COC COCAINE IMMUNE SYSTEM 03/12/01 ANTIBODY GNC92H2 BOUND TO LIGAND MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Larsen, N.A., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.265 0.220 False True IGHV9 IGKV3 Kappa 4e-07 -8.728351841232218 Unknown TBD 6w0c A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Open-gate KcsA soaked in 4 mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 3.556 X-RAY DIFFRACTION 0.248 0.200 False True IGHV1 IGKV5 Kappa None None None None None 6cde 3 4 0 1 protein glycoprotein 41 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7ldj E NA 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/13/21 SARS-CoV-2 receptor binding domain in complex with WNb-2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Adair, A., Tham, W.H. 2.36 X-RAY DIFFRACTION 0.268 0.210 False True IGHV1 NA NA None None None None None 7lk9 C D 0 NA NA NA NA IMMUNE SYSTEM 02/01/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HC + COVD21-C8 LC HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 3.4 X-RAY DIFFRACTION 0.312 0.276 False True IGHV3 IGKV3 Kappa None None None None None 1f3d K J 0 J Hapten TPM 2-(4-AMINOBENZYLAMINO)-3,4,5,6-TETRAHYDROPYRIDINIUM IMMUNE SYSTEM 06/02/00 CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN. MUS MUSCULUS mus musculus mus musculus mus musculus Golinelli-Pimpaneau, B., Goncalves, O., Dintinger, T., Blanchard, D., Knossow, M., Tellier, C. 1.87 X-RAY DIFFRACTION 0.218 0.198 False False IGHV1 IGKV1 Kappa None None None None None 4m62 I M 0 T protein t117 IMMUNE SYSTEM 08/08/13 Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Finton, K.A.K. 1.8 X-RAY DIFFRACTION 0.216 0.189 False True IGHV1 IGKV3 Kappa 2.57e-09 -11.718947964134085 SPR TBD 4z5r M L 0 E protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 3kdm B A 0 B Hapten TES TESTOSTERONE IMMUNE SYSTEM 10/23/09 Crystal Structure of Human Anti-steroid Fab 5F2 in Complex with Testosterone HOMO SAPIENS homo sapiens homo sapiens homo sapiens Niemi, M.H., Rouvinen, J. 1.5 X-RAY DIFFRACTION 0.208 0.180 True True IGHV3 IGKV1 Kappa 1.00e-07 -9.54 Other 25 21360611 7zfe H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV3 IGKV3 Kappa None None None None None 6do1 D NA 0 B protein type-1 angiotensin ii receptor,soluble cytochrome b562 brilfusion protein MEMBRANE PROTEIN 06/08/18 Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8 HOMO SAPIENS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT synthetic construct homo sapiens, escherichia coli Wingler, L.M., McMahon, C., Staus, D.P., Lefkowitz, R.J., Kruse, A.C. 2.901 X-RAY DIFFRACTION 0.359 0.305 False True IGHV1 None None None None None 7mxe R W 0 J protein NA envelope glycoprotein bg505 sosip.664 gp120 ANTIVIRAL PROTEIN/VIRAL PROTEIN 05/19/21 Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Abernathy, M.E., Bjorkman, P.J. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV9 Lambda None None None None None 7nkt B NA 0 A protein NA unknown VIRAL PROTEIN 02/18/21 RBD domain of SARS-CoV2 in complex with neutralizing nanobody NM1226 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS Ostertag, E., Zocher, G., Stehle, T. 2.3 X-RAY DIFFRACTION 0.224 0.184 False False IGHV1 NA NA None None None None None 7te9 H L 0 D protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 class1 RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Furukawa, H. 3.92 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV19 Kappa None None None None None 3hmw H L 0 IMMUNE SYSTEM 05/29/09 Crystal structure of ustekinumab FAB HOMO SAPIENS homo sapiens homo sapiens Luo, J. 3.0 X-RAY DIFFRACTION 0.287 0.228 False True IGHV5 IGKV1D Kappa None None None None None 5dk3 B A 0 IMMUNE SYSTEM 09/02/15 Crystal Structure of Pembrolizumab, a full length IgG4 antibody HOMO SAPIENS homo sapiens homo sapiens Scapin, G., Prosise, W., Reichert, P. 2.28 X-RAY DIFFRACTION 0.224 0.184 False True IGHV1 IGKV3 Kappa None None None None None 7jr7 C D 0 B | A protein | protein NA | NA atp-binding cassette sub-family g member 8 | atp-binding cassette sub-family g member 5 TRANSLOCASE/IMMUNE SYSTEM 08/11/20 Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Huang, C.S., Yu, X., Min, X., Wang, Z., Zhang, H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 7n6p A B 0 NA NA NA NA IMMUNE SYSTEM 06/08/21 Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab HOMO SAPIENS homo sapiens homo sapiens Milligan, J.C., Yu, X., Buck, T., Saphire, E.O. 2.15 X-RAY DIFFRACTION 0.231 0.175 False True IGHV1 IGKV4 Kappa None None None None None 5w9j H I 0 G protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 1bm3 H L 0 IMMUNE SYSTEM 04/15/99 IMMUNOGLOBULIN OPG2 FAB-PEPTIDE COMPLEX MUS MUSCULUS mus musculus mus musculus Kodandapani, R., Veerapandian, L., Ni, C.Z., Chiou, C.-K., Whital, R., Kunicki, T.J., Ely, K.R. 2.0 X-RAY DIFFRACTION unknown 0.152 False False IGHV5 IGKV5 Kappa None None None None None 6e8v U V 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False True IGHV1 IGLV1 Lambda None None None None None 7nka F NA 0 NA NA NA NA VIRAL PROTEIN 02/17/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8206 INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 4.07 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5vxk B NA 0 A protein invasin ipad IMMUNE SYSTEM 05/23/17 2.55 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-H2 VICUGNA PACOS; SHIGELLA FLEXNERI vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.55 X-RAY DIFFRACTION 0.273 0.202 False True IGHV1 None None None None None 2qtj B M 9 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4xzu A B 0 M protein coagulation factor viii IMMUNE SYSTEM 02/05/15 Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Spiegel, P.C., Wuerth, M.E. 2.61 X-RAY DIFFRACTION 0.267 0.199 False False IGHV9 IGKV4 Kappa None None None None None 7m3i A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 03/18/21 Structure of SARS-CoV-2 spike protein receptor binding domain in complex with a neutralizing antibody, CV2-75 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hurlburt, N.K., Pancera, M. 2.8 X-RAY DIFFRACTION 0.281 0.245 False True IGHV4 IGLV3 Lambda None None None None None 6ol7 I F 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV1 IGKV3 Kappa None None None None None 2or9 H L 0 P peptide synthetic epitope peptide of 9e10 IMMUNE SYSTEM 02/02/07 The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Krauss, N., Scheerer, P., Hoehne, W. 2.7 X-RAY DIFFRACTION 0.310 0.252 False False IGHV5 IGKV3 Kappa 5.00e-07 -8.6 ITC 25 18473392 5id1 B A 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with MPT-Cys meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.49 X-RAY DIFFRACTION 0.221 0.173 False True IGHV2 IGKV5 Kappa 5.6e-07 -8.528997532261052 Unknown TBD 6oyh H NA 0 D protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/14/19 Crystal structure of MraY bound to carbacaprazamycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 2.95 X-RAY DIFFRACTION 0.268 0.249 False True IGHV1 None None None None None 1t66 H L 0 L Hapten FLU 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID IMMUNE SYSTEM 05/05/04 The structure of FAB with intermediate affinity for fluorescein. MUS MUSCULUS mus musculus mus musculus mus musculus Terzyan, S., Ramsland, P.A., Voss Jr., E.W., Herron, J.N., Edmundson, A.B. 2.3 X-RAY DIFFRACTION 0.253 0.204 False False IGHV6 IGKV1 Kappa None None None None None 7vuh N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/02/21 Cryo-EM structure of a class A orphan GPCR HOMO SAPIENS; BACILLUS CIRCULANS homo sapiens homo sapiens | homo sapiens Liu, Z.J., Hua, T., Zhou, Y.L., Wu, L.J. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6mwn C D 0 B nucleic-acid hav dv rna (92-mer) RNA/Immune System 10/29/18 Crystal structure of hepatitis A virus IRES domain V in complex with Fab HAVx HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatovirus a Koirala, D., Shao, Y., Piccirilli, J.A. 2.838 X-RAY DIFFRACTION 0.252 0.186 False True IGHV3 IGKV1 Kappa None None None None None 3hzy B A 0 A carbohydrate KDA polysaccharide IMMUNE SYSTEM 06/24/09 Crystal structure of S73-2 antibody in complex with antigen Kdo(2.4)Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Muller-Loennies, S., Borisova, S.N., Brade, L., Kosma, P., Hirama, T., MacKenzie, C.R., Brade, H., Evans, S.V. 2.1 X-RAY DIFFRACTION 0.261 0.216 False False IGHV7 IGKV8 Kappa 1e-07 -9.54970862587178 Unknown TBD 6hjy F NA 0 A protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.78 X-RAY DIFFRACTION 0.233 0.225 False True IGHV1 None None None None None 4yny A B 0 IMMUNE SYSTEM 03/11/15 Crystal structure of monoclonal anti-human podoplanin antibody NZ-1 RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Fujii, Y., Kitago, Y., Arimori, T., Takagi, J. 1.584 X-RAY DIFFRACTION 0.204 0.168 False True IGHV5 IGLV3 Lambda None None None None None 4wht U V 0 u peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 4w2q C NA 0 D protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS lama glama lake victoria marburgvirus Taylor, A.B., Garza, J.A. 2.7 X-RAY DIFFRACTION 0.274 0.220 False True IGHV1 None None None None None 3lh2 I M 0 T protein 4e10_1vi7a_s0_002_n (t88) IMMUNE SYSTEM 01/21/10 Crystal structure of HIV epitope-scaffold 4E10_1VI7A_S0_002_N 4E10 Fv complex ARTIFICIAL GENE; HOMO SAPIENS homo sapiens homo sapiens artificial gene Holmes, M.A. 2.65 X-RAY DIFFRACTION 0.270 0.222 False True IGHV1 IGKV3 Kappa 5.60e-09 -11.25 SPR 20826338 7lly N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/04/21 Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein HOMO SAPIENS; LAMA GLAMA; SUS SCROFA lama glama homo sapiens | homo sapiens Wootten, D., Sexton, P.M., Belousoff, M.J., Danev, R., Zhang, X., Khoshouei, M., Venugopal, H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7qjj F NA 0 E protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of a Mn2+ soak of EleNRMT in complex with two Nanobodies at 4.6A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.6 X-RAY DIFFRACTION 0.327 0.284 False True IGHV1 NA NA None None None None None 6zqk B NA 0 NA NA NA NA ANTITUMOR PROTEIN 07/09/20 HER2-binding scFv-Fab fusion 841 MUS MUSCULUS mus musculus Kast, F., Schwill, M., Stueber, J.C., Pfundstein, S., Nagy-Davidescu, G., Monne Rodriguez, J.M., Seehusen, F., Richter, C.P., Honegger, A., Hartmann, K.P., Weber, T.G., Kroener, F., Ernst, P., Piehler, J., Plueckthun, A. 2.2 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 NA NA None None None None None 4n8c I M 0 Y peptide extracellular domain of influenza matrix protein 2 IMMUNE SYSTEM 10/17/13 Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus influenza a virus (a/puerto rico/8/1934(h1n1)) Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H. 1.6 X-RAY DIFFRACTION 0.242 0.193 False False IGHV1 IGKV8 Kappa 4.0000000000000007e-10 -12.821084109462982 Unknown TBD 7pi3 Y Z 0 V protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 7mzm H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab PDI 215 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.3 X-RAY DIFFRACTION 0.257 0.216 False True IGHV3 IGKV3 Kappa None None None None None 6mtq H L 0 T protein vrc42 epitope t117-f scaffold IMMUNE SYSTEM 10/21/18 Crystal structure of VRC42.N1 Fab in complex with T117-F MPER scaffold HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Law, W.H., Veradi, R., Doria-Rose, N.A., Kwong, P.D. 2.7 X-RAY DIFFRACTION 0.259 0.206 False True IGHV1 IGKV3 Kappa None None None None None 1a4j B A 0 IMMUNOGLOBULIN 01/30/98 DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR MUS MUSCULUS mus musculus mus musculus Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C. 2.1 X-RAY DIFFRACTION 0.292 0.229 False True IGHV9 IGKV1 Kappa None None None None None 4n90 H I 0 T | C protein | protein NA | NA tumor necrosis factor receptor superfamily member 10b | tumor necrosis factor ligand superfamily member 10 Apoptosis/Immune System 10/18/13 Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Huang, X. 3.3 X-RAY DIFFRACTION 0.286 0.229 False True IGHV4 IGKV3 Kappa None None None None None 6xy2 H L 0 A protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 01/29/20 Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gao, H., Zhou, A. 3.05 X-RAY DIFFRACTION 0.293 0.249 False True IGHV4 IGKV1 Kappa None None None None None 6dzm G H 0 D | A protein | protein NA | NA bundibugyo virus gp2 | bundibugyo virus gp1 VIRAL PROTEIN 07/05/18 Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus | bundibugyo ebolavirus Murin, C.D., Ward, A.B. 4.29 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 2b4c H L 0 G | C protein | protein NA | NA envelope glycoprotein | t-cell surface glycoprotein cd4 Viral protein/Immune system 09/23/05 Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | homo sapiens Huang, C., Tang, M., Zhang, M.Y., Majeed, S., Montabana, E., Stanfield, R.L., Dimitrov, D.S., Korber, B., Sodroski, J., Wilson, I.A., Wyatt, R., Kwong, P.D. 3.3 X-RAY DIFFRACTION 0.349 0.319 False True IGHV1 IGKV3 Kappa None None None None None 4r97 C B 0 IMMUNE SYSTEM 09/03/14 Crystal structure of the Fab fragment of KKO MUS MUSCULUS mus musculus mus musculus Cai, Z., Zhu, Z., Liu, Q., Greene, M.I. 2.2 X-RAY DIFFRACTION 0.262 0.200 False True IGHV1 IGKV6 Kappa None None None None None 7b2m D NA 0 B | A protein | protein NA | NA complement c4 alpha chain | complement c4 beta chain IMMUNE SYSTEM 11/27/20 Cryo-EM structure of complement C4b in complex with nanobody E3 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Oosterheert, W., De la O Becerra, K.I., van den Bos, R.M., Gros, P. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5mp1 H L 0 A peptide microtubule-associated protein tau IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 3.1 X-RAY DIFFRACTION 0.268 0.222 False False IGHV1 IGKV8 Kappa None None None None None 6j7w A NA 0 C peptide tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 01/18/19 Crystal Structure of Human BCMA in complex with UniAb(TM) VH HOMO SAPIENS homo sapiens homo sapiens Clarke, S.C., Ma, B., Trinklein, N.D., Schellenberger, U., Osborn, M., Ouisse, L., Boudreau, A., Davison, L., Harris, K.E., Ugamraj, H., Balasubramani, A., Dang, K., Jorgensen, B., Ogana, H., Pham, D., Pratap, P., Sankaran, P., Anegon, I., van Schooten, W., Bruggemann, M., Buelow, R., Force Aldred, S. 2.6 X-RAY DIFFRACTION 0.271 0.209 False True IGHV3 None None None None None 7sob M L 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5fyl H L 0 G protein bg505 gp120 env ectodomain 03/08/16 Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Stewart-Jones, G.B.E., Zhou, T., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.3072 0.2503 False True IGHV4 IGLV3 Lambda None None None None None 7ws2 E D 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6anp B A 0 IMMUNE SYSTEM 08/14/17 CAT192 Fab Insertion Mutant H5/L0 HOMO SAPIENS homo sapiens homo sapiens Lord, D.M., Wei, R.R. 2.45 X-RAY DIFFRACTION 0.235 0.183 False True IGHV3 IGKV1 Kappa None None None None None 5xct A B 0 C peptide c8 peptide IMMUNE SYSTEM 03/23/17 Crystal structure of P20.1 Fv-clasp fragment with its antigen peptide MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 1.17 X-RAY DIFFRACTION 0.185 0.152 False True IGHV9 IGLV1 Lambda None None None None None 6co3 H L 0 Q peptide ala-glu-phe-arg-his-asp IMMUNE SYSTEM 03/10/18 aducanumab abeta complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Arndt, J.W. 2.384 X-RAY DIFFRACTION 0.235 0.181 False True IGHV3 IGKV1 Kappa None None None None None 3bkj H L 0 A peptide amyloid beta peptide IMMUNE SYSTEM 12/06/07 Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Miles, L.A., Wun, K.S., Crespi, G.A., Fodero-Tavoletti, M., Galatis, D., Bageley, C.J., Beyreuther, K., Masters, C.L., Cappai, R., McKinstry, W.J., Barnham, K.J., Parker, M.W. 1.59 X-RAY DIFFRACTION 0.231 0.188 False False IGHV8 IGKV1 Kappa None None None None None 2z91 C D 0 IMMUNE SYSTEM 09/14/07 Crystal structure of the Fab fragment of anti-ciguatoxin antibody 10C9 MUS MUSCULUS mus musculus mus musculus Ui, M., Tanaka, Y., Tsumoto, K. 2.6 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV4 Kappa None None None None None 6okn A B 0 R protein tumor necrosis factor receptor superfamily member 4 IMMUNE SYSTEM 04/14/19 OX40R (TNFRSF4) bound to Fab 1A7 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M.H., Boenig, G., Harris, S.F. 3.25 X-RAY DIFFRACTION 0.228 0.192 False True IGHV1 IGKV1 Kappa None None None None None 5foj A NA 0 B protein grapevine fanleaf virus 11/22/15 Electron cryo-microscopy of Grapevine Fanleaf Virus complex with Nanobody GRAPEVINE FANLEAF VIRUS grapevine fanleaf virus grapevine fanleaf virus Hemmer, C., Orlov, I., Ackerer, L., Marmonier, A., Hleibieh, K., Schmitt-Keichinger, C., Vigne, E., Gersch, S., Komar, V., Belval, L., Berthold, F., Monsion, B., Bron, P., Lemaire, O., Lorber, B., Sgro, J.Y., Gutierrez, C., Muyldermans, S., Demangeat, G., Klaholz, B.P., Ritzenthaler, C. 2.8 ELECTRON MICROSCOPY False False IGHV1 None None None None None 6xun H L 0 E carbohydrate NAG N-ACETYL-D-GLUCOSAMINE ANTITUMOR PROTEIN 01/20/20 Ab 5b1 bound to CA19-9 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.215 0.169 False True IGHV3 IGLV1 Lambda None None None None None 3cm9 D O 6 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 2kh2 B b 4 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 3j2y D C 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab 9.8B MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 14.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 7rth D C 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 3bd4 NA A 0 IMMUNE SYSTEM 11/14/07 Crystal structure of single domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals MUS MUSCULUS mus musculus Park, S.K., Kim, J.S. 2.4 X-RAY DIFFRACTION 0.281 0.213 True True IGKV8 Kappa None None None None None 6p8n H L 0 C protein env outer domain eod-gt8 IMMUNE SYSTEM 06/07/19 Crystal Structure of Antibody P-p1f1 in Complex with eOD-GT8 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Weidle, C., Pancera, M. 3.202 X-RAY DIFFRACTION 0.287 0.226 False True IGHV1 IGKV8 Kappa None None None None None 7ryv H L 0 NA NA NA NA IMMUNE SYSTEM 08/26/21 Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques MACACA MULATTA macaca mulatta macaca mulatta Yang, Z., Bjorkman, P.J. 2.5 X-RAY DIFFRACTION 0.254 0.216 False True IGHV1 IGLV1 Lambda None None None None None 7kxj I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/04/20 SARS-CoV-2 spike protein in complex with Fab 15033-7, 3-""up"", asymmetric SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J. 6.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3r08 H L 0 E protein t-cell surface glycoprotein cd3 epsilon chain IMMUNE SYSTEM 03/07/11 Crystal structure of mouse cd3epsilon in complex with antibody 2C11 Fab CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius cricetulus migratorius Shore, D.A., Zhu, X., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.277 0.222 False True IGHV5 IGKV14 Kappa None None None None None 7mlz H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 04/29/21 Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 3.71 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3zkq D NA 0 A protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 01/24/13 BACE2 XAPERONE COMPLEX LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 1.51 X-RAY DIFFRACTION 0.22276 0.18966 False True IGHV3 1.2e-09 -12.170174257779676 SPR TBD 4hwb H L 0 A protein interleukin-13 receptor subunit alpha-1 IMMUNE SYSTEM 11/07/12 Crystal structure of ectodomain 3 of the IL-13 receptor alpha 1 in complex with a human neutralizing monoclonal antibody fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xu, Y. 2.61 X-RAY DIFFRACTION 0.224 0.197 False True IGHV5 IGKV3 Kappa 5.7e-10 -12.611243089917517 Unknown TBD 7ljb G F 0 B protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.97 X-RAY DIFFRACTION 0.240 0.196 False True IGHV1 IGKV4 Kappa None None None None None 3p9w D NA 0 C protein vascular endothelial growth factor a SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/10 Crystal structure of an engineered human autonomous VH Domain in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens Ma, X., Wiesmann, C. 2.41 X-RAY DIFFRACTION 0.233 0.193 False True IGHV3 1.6e-08 -10.635483235413165 SPR TBD 5w9o B C 0 A protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.5 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7tes H L 0 B | A protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in Non-active1 conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 5nbl F NA 0 D | A protein | protein NA | NA actin | actin-related protein 4 HYDROLASE 03/02/17 Crystal structure of the Arp4-N-actin(APO-state) heterodimer bound by a nanobody SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS; TRICHOPLUSIA NI vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) | saccharomyces cerevisiae (strain atcc 204508 /s288c) Knoll, K.R., Eustermann, S., Hopfner, K.P. 2.8 X-RAY DIFFRACTION 0.204 0.171 False True IGHV1 None None None None None 7b0b H L 0 F protein NA surface glycoprotein ANTIVIRAL PROTEIN 11/19/20 Fab HbnC3t1p1_C6 bound to SARS-CoV-2 RBD HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Borenstein-Katz, A., Diskin, R. 2.98 X-RAY DIFFRACTION 0.246 0.209 False True IGHV1 IGKV3 Kappa None None None None None 6xsw H L 0 X protein NA neurogenic locus notch homolog protein 3 SIGNALING PROTEIN/Immune System 07/16/20 Structure of the Notch3 NRR in complex with an antibody Fab Fragment RATTUS NORVEGICUS; HOMO SAPIENS rattus norvegicus rattus norvegicus homo sapiens Bard, J. 2.98 X-RAY DIFFRACTION 0.256 0.233 False True IGHV3 IGKV1 Kappa None None None None None 6x3z K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.23 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 6vln H L 0 P | K peptide | protein NA | NA circumsporozoite protein | anti kappa vhh domain IMMUNE SYSTEM 06/17/20 Crystal structure of 4498 Fab in complex with circumsporozoite protein DND3 and anti-Kappa VHH domain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | camelidae mixed library Thai, E., Scally, S.W., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 1.63 X-RAY DIFFRACTION 0.234 0.209 False True IGHV3 IGKV3 Kappa None None None None None 5vic H L 0 E protein dengue 1 envelope diii domain IMMUNE SYSTEM 04/14/17 Crystal structure of anti-Zika antibody Z004 bound to DENV-1 Envelope protein DIII HOMO SAPIENS; DENGUE VIRUS TYPE 1 (STRAIN NAURU/WEST PAC/1974) homo sapiens homo sapiens dengue virus type 1 (strain nauru/westpac/1974) Keeffe, J.R., West Jr., A.P., Gristick, H.B., Bjorkman, P.J. 3.0 X-RAY DIFFRACTION 0.286 0.235 False True IGHV3 IGKV1 Kappa None None None None None 6kn9 D d 0 A protein interleukin-18 receptor accessory protein CYTOKINE 08/05/19 Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv HOMO SAPIENS homo sapiens homo sapiens Wu, D.H., Liu, C.C. 3.302 X-RAY DIFFRACTION 0.277 0.247 True True unknown unknown unknown None None None None None 1nma H L 0 N protein n9 neuraminidase COMPLEX (HYDROLASE/IMMUNOGLOBULIN) 05/06/94 N9 NEURAMINIDASE COMPLEXES WITH ANTIBODIES NC41 AND NC10: EMPIRICAL FREE-ENERGY CALCULATIONS CAPTURE SPECIFICITY TRENDS OBSERVED WITH MUTANT BINDING DATA INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Tulip, W.R., Varghese, J.N., Colman, P.M. 3.0 X-RAY DIFFRACTION unknown 0.200 False False IGHV1 IGKV10 Kappa 1.40e-08 -10.8 Other 7517697 5m2i J NA 0 E protein tumor necrosis factor CYTOKINE 10/13/16 Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.15 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 5.400000000000001e-10 -12.643277036143104 SPR TBD 6xw7 G NA 0 E protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5829 and glycochenodeoxycholate (GCDCA) MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 2.15 X-RAY DIFFRACTION 0.215 0.171 False True IGHV1 None None None None None 6b73 C NA 0 B protein soluble cytochrome b562, kappa-type opioid receptor MEMBRANE PROTEIN/AGONIST 10/03/17 Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor ESCHERICHIA COLI; HOMO SAPIENS; LAMA GLAMA lama glama escherichia coli, homo sapiens Che, T., Majumdar, S., Zaidi, S.A., Kormos, C., McCorvy, J.D., Wang, S., Mosier, P.D., Uprety, R., Vardy, E., Krumm, B.E., Han, G.W., Lee, M.Y., Pardon, E., Steyaert, J., Huang, X.P., Strachan, R.T., Tribo, A.R., Pasternak, G.W., Carroll, I.F., Stevens, R.C., Cherezov, V., Katritch, V., Wacker, D., Roth, B.L. 3.1 X-RAY DIFFRACTION 0.275 0.254 False True IGHV1 None None None None None 1ieh A NA 3 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 5c6w J j 0 IMMUNE SYSTEM 06/23/15 anti-CXCL13 scFv - E10 HOMO SAPIENS homo sapiens Tu, C., Bard, J., Mosyak, L. 1.54 X-RAY DIFFRACTION 0.164 0.154 True True unknown unknown unknown None None None None None 2fx8 K O 0 S peptide fragment of hiv glycoprotein (gp41) IMMUNE SYSTEM 02/03/06 Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Brunel, F.M., Ferguson, S., Burton, D.R., Dawson, P.E., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.283 0.235 False True IGHV1 IGKV3 Kappa 3.02e-07 -8.89 SPR 17125793 7lrt H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/17/21 Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody A23-58.1 that targets the receptor-binding domain HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4ma7 H L 0 A protein major prion protein IMMUNE SYSTEM 08/15/13 Crystal structure of mouse prion protein complexed with Promazine MUS MUSCULUS mus musculus mus musculus mus musculus Baral, P.K., Swayampakula, M., James, M.N.G. 1.97 X-RAY DIFFRACTION 0.247 0.216 False True IGHV1 IGKV5 Kappa None None None None None 3j6u H L 0 C | A protein | protein NA | NA envelope protein | envelope protein VIRUS/IMMUNE SYSTEM 03/26/14 Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab HOMO SAPIENS; DENGUE VIRUS 3 homo sapiens homo sapiens dengue virus 3 | dengue virus 3 Fibriansah, G., Tan, J.L., Smith, S.A., de Alwis, R., Ng, T.-S., Kostyuchenko, V.A., Kukkaro, P., de Silva, A.M., Crowe Jr., J.E., Lok, S.-M. 9 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7llk C D 0 A protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/04/21 Cryo-EM structure of Q23.17_DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody 179NC75 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 4.8 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6m58 H L 0 A protein serum albumin IMMUNE SYSTEM 03/10/20 Crystal structure of a complex between human serum albumin and the antibody Fab SL335 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Cho, S.Y., Yoon, S.I. 2.95 X-RAY DIFFRACTION 0.242 0.193 False True IGHV3 IGKV3 Kappa None None None None None 2x1q A NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama VandenAbbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., VanLoo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.06 X-RAY DIFFRACTION 0.229 0.213 False True IGHV1 None None None None None 5adp H L 0 08/21/15 Crystal structure of the A.17 antibody FAB fragment - Light chain S35R mutant HOMO SAPIENS homo sapiens homo sapiens Chatziefthimiou, S.D., Smirnov, I.V., Golovin, A.V., Stepanova, A.V., Peng, Y., Zolotareva, O.I., Belogurov, A.A., Ponomarenko, N.A., Blackburn, G.M., Gabibov, A.A., Lerner, R., Wilmanns, M. 2.13 X-RAY DIFFRACTION 0.220 0.179 False True IGHV4 IGLV1 Lambda None None None None None 7l6v C NA 0 A protein NA bont/a ANTITOXIN 12/24/20 Crystal structure of BoNT/A-LC-JPU-A5-JPU-C1-JPU-H7-JPU-D12-ciA-F12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.01 X-RAY DIFFRACTION 0.234 0.197 False True IGHV1 NA NA None None None None None 7kex H K 0 B protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-293 HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6w00 H L 0 P peptide NA npna2 peptide IMMUNE SYSTEM 02/28/20 Crystal structure of Fab239 in complex with NPNA2 peptide from circumsporozoite protein STREPTOCOCCUS SP. GROUP G; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 1.853 X-RAY DIFFRACTION 0.206 0.187 False True IGHV3 IGKV1 Kappa None None None None None 6w52 H L 0 B | A protein | protein NA | NA fusion glycoprotein f1 fused with fibritin trimerizationdomain | fusion glycoprotein f0 VIRAL PROTEIN 03/12/20 Prefusion RSV F bound by neutralizing antibody RSB1 HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN RESPIRATORY SYNCYTIAL VIRUS A; ESCHERICHIA PHAGE T2; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a,escherichia phage t2 | human respiratory syncytial virus a (straina2) Harshbarger, W., Chandramouli, S., Malito, M. 3.74 X-RAY DIFFRACTION 0.286 0.218 False True IGHV1 IGLV2 Lambda None None None None None 1il1 A B 0 IMMUNE SYSTEM 05/07/01 Crystal structure of G3-519, an anti-HIV monoclonal antibody MUS MUSCULUS mus musculus mus musculus Berry, M.B., Johnson, K.A., Radding, W., Fung, M., Liou, R., Phillips Jr., G.N. 2.2 X-RAY DIFFRACTION 0.246 0.188 False False IGHV14 IGKV8 Kappa None None None None None 1mce NA A 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 1mak NA A 7 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5wko G H 0 V | S protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 07/25/17 Crystal structure of antibody 27F3 recognizing the HA from A/California/04/2009 (H1N1) influenza virus HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wilson, A., Lang, S., Zhu, X. 3.492 X-RAY DIFFRACTION 0.268 0.246 False True IGHV1 IGKV3 Kappa None None None None None 7ur4 H L 0 C protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 04/21/22 Cryo-EM Structure of the Neutralizing Antibody MPV467 in Complex with Prefusion Human Metapneumovirus F Glycoprotein HUMAN METAPNEUMOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human metapneumovirus Rush, S.A., McLellan, J.S. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 5hbv D C 0 B protein acetylcholine receptor subunit alpha 1 TRANSPORT PROTEIN/TOXIN 01/02/16 Complex structure of Fab35 and mouse nAChR alpha1 MUS MUSCULUS; BUNGARUS MULTICINCTUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Noridomi, K., Watanabe, G., Hansen, M.N., Han, G.W., Chen, L. 2.7 X-RAY DIFFRACTION 0.268 0.227 False False IGHV2 IGKV22 Kappa None None None None None 4kka E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 20mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.0 X-RAY DIFFRACTION 0.265 0.220 False True IGHV4 IGKV4 Kappa None None None None None 7rqq H L 0 P peptide NA pfcsp peptide nanpnvdp IMMUNE SYSTEM 08/06/21 Structure of chimeric antibody F10heavy_L9light with PfCSP peptide NANPNVDP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Hurlburt, N.K., Pancera, M. 1.89 X-RAY DIFFRACTION 0.204 0.161 False True IGHV3 IGKV1 Kappa None None None None None 6qv1 F NA 0 D | C protein | protein NA | NA uncharacterized abc transporter atp-binding proteintm_0288 | abc transporter, atp-binding protein MEMBRANE PROTEIN 03/01/19 Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM1 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); VICUGNA PACOS vicugna pacos thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) | thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 3.48 X-RAY DIFFRACTION 0.303 0.267 False True IGHV1 NA NA None None None None None 7l2f I K 0 B protein NA spike glycoprotein Viral Protein/IMMUNE SYSTEM 12/16/20 Cryo-EM structure of NTD-directed neutralizing antibody 5-24 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 2rcj N O 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 6xxv D E 0 F protein s2_1.2 IMMUNE SYSTEM 01/28/20 Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yang, C., Sesterhenn, F., Correia, B.E., Pojer, F. 2.20116 X-RAY DIFFRACTION 0.244 0.209 False True IGHV3 IGKV1 Kappa None None None None None 6lyn A B 0 C protein NA cell surface glycoprotein muc18 CELL ADHESION 02/14/20 CD146 D4-D5/AA98 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Chen, X., Yan, X. 2.776 X-RAY DIFFRACTION 0.262 0.217 False True IGHV1 IGKV3 Kappa None None None None None 4kze H L 0 R nucleic-acid rna (84-mer) immune system/rna 05/29/13 Crystal structure of an RNA aptamer in complex with Fab MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Huang, H., Suslov, N.B., Li, N., Koldobskaya, Y., Rice, P.A., Piccirilli, J.A. 2.404 X-RAY DIFFRACTION 0.224 0.186 False True IGHV3 IGKV1 Kappa 2.5000000000000002e-08 -10.371065410511342 Unknown TBD 1rmf H L 0 IMMUNOGLOBULIN 12/16/94 STRUCTURES OF A MONOCLONAL ANTI-ICAM-1 ANTIBODY R6.5 FRAGMENT AT 2.8 ANGSTROMS RESOLUTION MUS MUSCULUS mus musculus mus musculus Jedrzejas, M.J., Luo, M. 2.8 X-RAY DIFFRACTION unknown 0.188 False True IGHV1 IGKV1 Kappa None None None None None 7ndc D E 0 C protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-159 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4xwg H L 0 A protein phosphatidylcholine-sterol acyltransferase Hydrolase/Immune system 01/28/15 Crystal Structure of LCAT (C31Y) in complex with Fab1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T. 2.65 X-RAY DIFFRACTION 0.251 0.176 False True IGHV3 IGLV3 Lambda None None None None None 5w1k G F 0 E protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV3 IGKV1 Kappa None None None None None 7mly G J 0 B protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7vfb B NA 0 A protein NA 3c-like proteinase VIRAL PROTEIN/IMMUNE SYSTEM 09/11/21 the complex of SARS-CoV2 3cl and NB2B4 CAMELUS BACTRIANUS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Geng, Y., Sun, Z.C., Wang, L. 2.0 X-RAY DIFFRACTION 0.264 0.236 False True IGHV1 NA NA None None None None None 7b3o H L 0 E protein NA surface glycoprotein ANTIVIRAL PROTEIN 12/01/20 Crystal structure of the SARS-CoV-2 RBD in complex with STE90-C11 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kluenemann, T., Van den Heuvel, J. 2.0 X-RAY DIFFRACTION 0.225 0.185 False True IGHV3 IGKV1 Kappa None None None None None 5cip A B 0 IMMUNE SYSTEM 07/13/15 Crystal Structure of Unbound 4E10 HOMO SAPIENS homo sapiens homo sapiens Caaveiro, J.M.M., Rujas, E., Nieva, J.L., Tsumoto, K. 2.48 X-RAY DIFFRACTION 0.231 0.183 False True IGHV1 IGKV3 Kappa None None None None None 6a3w J K 0 L protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 06/17/18 Complex structure of 4-1BB and utomilumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F. 2.0 X-RAY DIFFRACTION 0.215 0.185 False True IGHV5 IGLV3 Lambda None None None None None 7k7y F NA 0 E protein NA botulinum neurotoxin type e ANTITOXIN 09/24/20 Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 3.6 X-RAY DIFFRACTION 0.288 0.261 False True IGHV1 NA NA None None None None None 5i9q B C 0 A protein 426c.tm4dv1-3 p120 IMMUNE SYSTEM 02/20/16 Crystal structure of 3BNC55 Fab in complex with 426c.TM4deltaV1-3 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Chen, C., Bjorkman, P.J. 3.0 X-RAY DIFFRACTION 0.270 0.251 False True unknown IGKV1 Kappa None None None None None 3mls K O 0 S peptide rationally designed v3 mimotope IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Kong, X.-P. 2.5 X-RAY DIFFRACTION 0.274 0.216 False False IGHV5 IGLV3 Lambda None None None None None 1oay H L 0 H Hapten FUR FURAZOLIDONE IMMUNE SYSTEM 01/21/03 Antibody multispecificity mediated by conformational diversity RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.66 X-RAY DIFFRACTION 0.280 0.258 False True IGHV1 IGLV1 Lambda 1.20e-06 Other 20 12610298 6krz F G 0 B protein NA adiponectin receptor protein 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/22/19 Crystal structure of the human adiponectin receptor 1 D208A mutant HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Tanabe, H., Fujii, Y., Okada-Iwabu, M., Iwabu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S. 3.05 X-RAY DIFFRACTION 0.273 0.216 False True IGHV1 IGKV12 Kappa None None None None None 7kqe H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/15/20 SARS-CoV-2 spike glycoprotein:Fab 3D11 complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Asarnow, D., Charles, C., Cheng, Y. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 5te4 H L 0 G protein hiv-1 clade g strain x2088 gp120 IMMUNE SYSTEM 09/20/16 Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade G Strain X2088 gp120 Core HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.75 X-RAY DIFFRACTION 0.267 0.208 False True unknown unknown unknown 9.900000000000001e-09 -10.919907375253752 SPR TBD 5jqh C NA 0 A protein endolysin,beta-2 adrenergic receptor signaling protein, hydrolase/inhibitor 05/05/16 Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60 LAMA GLAMA; ENTEROBACTERIA PHAGE T4 lama glama enterobacteria phage t4, homo sapiens Staus, D.P., Strachan, R.T., Manglik, A., Pani, B., Kahsai, A.W., Kim, T.H., Wingler, L.M., Ahn, S., Chatterjee, A., Masoudi, A., Kruse, A.C., Pardon, E., Steyaert, J., Weis, W.I., Prosser, R.S., Kobilka, B.K., Costa, T., Lefkowitz, R.J. 3.2 X-RAY DIFFRACTION 0.290 0.247 False True IGHV1 None None None None None 7e5s V S 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7r8n M N 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C051 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 5ec2 A B 0 C protein ph-gated potassium channel kcsa MEMBRANE PROTEIN 10/20/15 KcsA with V76ester+G77dA mutations STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Matulef, K., Valiyaveetil, F.I. 2.3 X-RAY DIFFRACTION 0.259 0.230 False True IGHV1 IGKV5 Kappa None None None None None 4o58 H L 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/3/1975 (H3N2) influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 2.7501 X-RAY DIFFRACTION 0.224 0.177 False True IGHV1 IGLV1 Lambda None None None None None 4xh2 C D 0 c peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD4 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.0 X-RAY DIFFRACTION 0.258 0.224 False True IGHV3 IGKV1 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 6cde 5 6 0 2 protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6idi I J 0 E protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 8.0. DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 12 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7wuh H I 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/08/22 SARS-CoV-2 Spike in complex with Fab of m31A7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Wu, Y.-M. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 1g9e A NA 18 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 1g9e A NA 3 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 2r9h C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 09/12/07 Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab ESCHERICHIA COLI; MUS MUSCULUS escherichia coli Nguitragool, W., Miller, C. 3.1 X-RAY DIFFRACTION 0.280 0.261 False True IGHV4 IGKV4 Kappa None None None None None 6tyl E NA 0 A protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 08/09/19 Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., McClelland, L., Yates-Hansen, C., Sprang, S.R. 3.3 X-RAY DIFFRACTION 0.287 0.248 False True IGHV1 None None None None None 7wui S s 0 A | B | G protein | protein | protein NA | NA | NA mini-gs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/08/22 Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 HOMO SAPIENS; LAMA GLAMA; MUS MUSCULUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Guo, S.C., He, Q.T., Xiao, P., Sun, J.P., Yu, X. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7v26 c d 0 C protein NA xg005 heavy chain VIRAL PROTEIN 08/07/21 XG005-bound SARS-CoV-2 S SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Sun, L., Chen, Z.G. 3.85 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 6a96 O NA 0 E protein gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/11/18 Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Liu, S., Xu, L., Guan, F., Liu, Y.T., Cui, Y., Zhang, Q., Bi, G.Q., Zhou, Z.H., Zhang, X., Ye, S. 3.51 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6gzp A NA 0 IMMUNE SYSTEM 07/04/18 Llama nanobody PorM_02 structure determined at room temperature by in-situ diffraction LAMA GLAMA lama glama Roche, J., Gaubert, A., Desmyter, A., De Wijn, R., Sauter, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.211 0.169 False True IGHV1 None None None None None 1lmk E e 0 IMMUNOGLOBULIN 08/29/94 THE STRUCTURE OF A BIVALENT DIABODY MUS MUSCULUS mus musculus Williams, R.L. 2.6 X-RAY DIFFRACTION unknown 0.200 True True unknown unknown unknown None None None None None 5e08 H L 0 N nucleic-acid rna Immune system/RNA 09/28/15 Specific Recognition of a Single-stranded RNA Sequence by an Engineered Synthetic Antibody Fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Huang, H., Qin, D., Li, N., Shao, Y., Staley, J.P., Kossiakoff, A.A., Koide, S., Piccirilli, J.A. 2.38 X-RAY DIFFRACTION 0.234 0.209 False True IGHV3 IGKV1 Kappa 1e-08 -10.913952715282035 Unknown TBD 2qtj A L 1 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6lnt P Q 0 E | B protein | protein NA | NA pre-membrane protein | envelope protein VIRUS 01/02/20 Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) | zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Tan, T.Y., Fibriansah, G., Kostyuchenko, V.A., Ng, T.S., Lim, X.X., Lim, X.N., Shi, J., Morais, M.C., Corti, D., Lok, S.M. 8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 6dkj H L 0 C protein gastric inhibitory polypeptide receptor SIGNALING PROTEIN 05/29/18 human GIPR ECD and Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Min, X., Wang, Z. 1.95 X-RAY DIFFRACTION 0.238 0.199 False True IGHV3 IGKV3 Kappa None None None None None 5uoe S T 0 D protein insulin-degrading enzyme Hydrolase/Immune System 01/31/17 Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J. 3.8 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV1 Kappa None None None None None 5ik3 A B 0 IMMUNE SYSTEM 03/03/16 Crystal structure of anti-gliadin 1002-1E03 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.65 X-RAY DIFFRACTION 0.236 0.196 False True IGHV3 IGKV4 Kappa None None None None None 6z3k Q R 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 7coe B C 0 D protein NA spike glycoprotein IMMUNE SYSTEM 08/04/20 Crystal structure of Receptor binding domain of MERS-CoV and KNIH90-F1 Fab complex HOMO SAPIENS; MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Lee, J.Y., Song, J.Y., Lee, H.S., Hong, E., Jang, T.H. 2.05 X-RAY DIFFRACTION 0.223 0.176 False True IGHV1 IGKV3 Kappa None None None None None 4u6g A B 0 C peptide sah-mper(662-683kkk)(b,q) IMMUNE SYSTEM 07/28/14 Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Bird, G.H., Walensky, L.D., Kwong, P.D. 4.2012 X-RAY DIFFRACTION 0.281 0.225 False True IGHV3 IGLV3 Lambda None None None None None 5a8h P O 0 M protein NA hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 23.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7v0v A NA 18 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7cec F G 0 B protein NA integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 06/22/20 Structure of alpha6beta1 integrin in complex with laminin-511 HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Miyazaki, N., Takagi, J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 2vq1 F E 0 IMMUNE SYSTEM 03/10/08 anti trimeric Lewis X Fab54-5C10-A MUS MUSCULUS mus musculus mus musculus de Geus, D.C., van Roon, A.M.M., Thomassen, E.A.J., Hokke, C.H., Deelder, A.M., Abrahams, J.P. 2.5 X-RAY DIFFRACTION 0.260 0.203 False False IGHV8 IGKV1 Kappa None None None None None 7jr7 E F 0 B protein NA atp-binding cassette sub-family g member 8 TRANSLOCASE/IMMUNE SYSTEM 08/11/20 Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Huang, C.S., Yu, X., Min, X., Wang, Z., Zhang, H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV13 Kappa None None None None None 2kh2 B b 1 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 3s35 H L 0 X protein vascular endothelial growth factor receptor 2 IMMUNE SYSTEM/Transferase 05/17/11 Structural basis for the function of two anti-VEGF receptor antibodies MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Franklin, M.C. 2.2 X-RAY DIFFRACTION 0.259 0.203 False True IGHV1 IGKV3 Kappa None None None None None 3juy B b 0 IMMUNE SYSTEM 09/15/09 Crystal Structure of a 3B3 Variant, a Broadly Neutralizing HIV-1 scFv Antibody HOMO SAPIENS homo sapiens Clark, K.R., Walsh, S.T. 2.5 X-RAY DIFFRACTION 0.260 0.195 True True unknown unknown unknown None None None None None 6gjq B NA 0 A protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/16/18 human NBD1 of CFTR in complex with nanobody T27 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.49 X-RAY DIFFRACTION 0.240 0.199 False True IGHV1 None None None None None 5dmg H L 0 P peptide microtubule-associated protein IMMUNE SYSTEM 09/08/15 X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430) ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus homo sapiens Benz, J., Lorenz, S., Georges, G., Jochner, A., Goepfert, U., Grueninger, F., Bujotzek, A. 2.5 X-RAY DIFFRACTION 0.263 0.210 False True IGHV1 IGKV1 Kappa None None None None None 6myy H L 0 A protein 426c ds-sosip d3 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/18 Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 3 Fabs bound, sharpened map HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Borst, A.J., Weidle, C.E., Gray, M.D., Frenz, B., Snijder, J., Joyce, M.G., Georgiev, I.S., Stewart-Jones, G.B.E., Kwong, P.D., McGuire, A.T., DiMaio, F., Stamatatos, L., Pancera, M., Veesler, D. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7rm0 C D 0 Q peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2E10.E9 in complex with P. vivax CSP peptide ANGAGNQPGANGAGNQPG MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 2.71 X-RAY DIFFRACTION 0.246 0.209 False True IGHV9 IGKV8 Kappa None None None None None 2qr0 H G 0 J protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 6mtn D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/20/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor Compound 484 in Complex with Human Antibodies 3H109L and 35O22 at 3.0 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.263 0.223 False True unknown unknown unknown None None None None None 1g9n H L 0 G protein envelope glycoprotein gp120 Viral protein/Immune system 11/25/00 HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwong, P.D., Wyatt, R., Majeed, S., Robinson, J., Sweet, R.W., Sodroski, J., Hendrickson, W.A. 2.9 X-RAY DIFFRACTION 0.295 0.207 False True IGHV1 IGKV3 Kappa None None None None None 5thr O L 0 F protein bg505 sosip gp120 VIRAL PROTEIN 09/30/16 Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 8.9, 8.9 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 1fvc B A 0 IMMUNOGLOBULIN 10/20/92 X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Randal, M., Kossiakoff, A.A., Presta, L. 2.2 X-RAY DIFFRACTION unknown 0.183 False True IGHV3 IGKV1 Kappa None None None None None 7kzx F E 0 A protein NA cadmium and zinc efflux pump fief MEMBRANE PROTEIN 12/10/20 Cryo-EM structure of YiiP-Fab complex in Apo state SHEWANELLA ONEIDENSIS; HOMO SAPIENS homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Fan, S., Koide, A., Koide, S., Beckstein, O., Stokes, D.L. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6pbv D C 0 I peptide junctional peptide IMMUNE SYSTEM 06/14/19 Crystal structure of Fab668 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Oyen, D., Wilson, I.A. 1.566 X-RAY DIFFRACTION 0.212 0.177 False True IGHV1 IGLV2 Lambda None None None None None 6cuf q r 0 d protein unknown VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 1cu4 H L 0 P peptide recognition peptide IMMUNE SYSTEM 08/20/99 CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kanyo, Z.F., Pan, K.M., Williamson, R.A., Burton, D.R., Prusiner, S.B., Fletterick, R.J., Cohen, F.E. 2.9 X-RAY DIFFRACTION 0.268 0.159 False False IGHV14 IGKV1 Kappa None None None None None 6yxm H L 0 B peptide NA unknown IMMUNE SYSTEM 05/03/20 Crystal structure of ACPA 1F2 in complex with CII-C-39-CIT HOMO SAPIENS Ge, C., Holmdahl, R. 2.85 X-RAY DIFFRACTION 0.276 0.210 False False IGHV7 unknown unknown None None None None None 1yeg H L 0 L Hapten BPN PARANITROBENZYL ALCOHOL CATALYTIC ANTIBODY 05/29/97 STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Knossow, M. 2.0 X-RAY DIFFRACTION 0.240 0.199 False False IGHV1 IGKV1 Kappa None None None None None 5ijv D C 0 IMMUNE SYSTEM 03/02/16 Crystal structure of bovine Fab E03 BOS TAURUS bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.247 0.204 False True IGHV1 IGLV1 Lambda None None None None None 7pg8 F D 0 H protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 6qkd NA M 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGKV3 Kappa None None None None None 6lcs A B 0 NA NA NA NA IMMUNE SYSTEM 11/19/19 Crystal structure of 73MuL9 Fv-clasp fragment in complex with GA-pyridine analogue MUS MUSCULUS mus musculus mus musculus Nakamura, T., Takagi, J., Yamagata, Y., Morioka, H. 2.6 X-RAY DIFFRACTION 0.260 0.214 False True IGHV3 IGKV4 Kappa None None None None None 3eyo D C 0 IMMUNE SYSTEM 10/21/08 Crystal structure of anti-human cytomegalovirus antibody 8F9 HOMO SAPIENS homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.5 X-RAY DIFFRACTION 0.268 0.241 False True IGHV3 IGKV3 Kappa None None None None None 5nb5 H L 0 IMMUNE SYSTEM 03/01/17 Principles for computational design of antibodies ESCHERICHIA COLI Dym, O., Fleishman, S.J. 3.0 X-RAY DIFFRACTION 0.257 0.223 False True IGHV3 IGKV3 Kappa None None None None None 1mak NA A 4 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 1cft B A 0 C peptide protein (antigen bound peptide) POLYSPECIFICITY 03/19/99 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED D-PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J., Hoehne, W. 2.8 X-RAY DIFFRACTION 0.328 0.237 False False IGHV1 IGKV14 Kappa None None None None None 6ban H G 0 P protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/14/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.95 X-RAY DIFFRACTION 0.196 0.160 False True IGHV1 IGKV1 Kappa None None None None None 6az2 A F 0 B protein histone chaperone asf1 IMMUNE SYSTEM 09/09/17 Crystal structure of Asf1-Fab 12E complex HOMO SAPIENS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C) homo sapiens homo sapiens saccharomyces cerevisiae (strain atcc 204508 /s288c) Bailey, L.J., Kossiakoff, A.A. 2.477 X-RAY DIFFRACTION 0.228 0.193 False True IGHV3 IGKV1 Kappa None None None None None 4nhh R P 0 N protein 2g12 igg dimer heavy chain IMMUNE SYSTEM 11/05/13 Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, Y., West Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 6.5 X-RAY DIFFRACTION 0.366 0.381 False True unknown IGKV1 Kappa None None None None None 4tnv U h 0 Q protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False unknown unknown unknown None None None None None 6ey6 L NA 0 D protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 2arj B A 0 R protein t-cell surface glycoprotein cd8 alpha chain Immune System 08/19/05 CD8alpha-alpha in complex with YTS 105.18 Fab MUS MUSCULUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Shore, D.A., Teyton, L., Dwek, R.A., Rudd, P.M., Wilson, I.A. 2.88 X-RAY DIFFRACTION 0.277 0.220 False False IGHV2 IGKV6 Kappa None None None None None 5f7l D NA 0 C protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with Nanobody Nb-ER14 HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.74 X-RAY DIFFRACTION 0.265 0.212 False True IGHV1 None None None None None 7mzi H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Tan, L.L., Dietrich, M.H., Chan, L.J., Tham, W.H. 1.85 X-RAY DIFFRACTION 0.208 0.174 False True IGHV3 IGLV1 Lambda None None None None None 6oao B b 0 A protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 092096 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 3.497 X-RAY DIFFRACTION 0.279 0.238 True True unknown unknown unknown None None None None None 7s6c H F 0 B protein NA 6-deoxyerythronolide-b synthase erya2, modules 3 and 4,lsd14 polyketide synthase fusion BIOSYNTHETIC PROTEIN 09/13/21 CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES LASALOCIDI; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea, streptomyceslasalocidi Bagde, S.R., Kim, C.-Y., Fromme, J.C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7sla B NA 0 A protein NA sodium/glucose cotransporter 1 MEMBRANE PROTEIN 10/23/21 CryoEM structure of SGLT1 at 3.15 Angstrom resolution HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Qu, Q., Han, L., Panova, O., Feng, L., Skiniotis, G. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7li6 B C 0 A protein NA sodium-dependent serotonin transporter MEMBRANE PROTEIN 01/26/21 apo SERT reconstituted in lipid nanodisc in KCl HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Gouaux, E. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 4w81 A NA 0 NA NA NA NA IMMUNE SYSTEM 08/22/14 Periplasmically Produced Monomeric Single Domain Antibody (sdAb) C22A/C99V variant against Staphylococcal enterotoxin B (SEB) at pH 8.0 LAMA GLAMA lama glama George, J., Legler, P.M. 2.25 X-RAY DIFFRACTION 0.233 0.193 False True IGHV1 NA NA None None None None None 4xnz B C 0 A protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 01/16/15 Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 3.389 X-RAY DIFFRACTION 0.301 0.244 False True unknown unknown unknown None None None None None 2kqn NA A 7 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 4aix NA B 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rC34Y, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.8 X-RAY DIFFRACTION 0.2119 0.1684 False True IGLV3 Lambda None None None None None 4lu5 I M 0 A protein a33r IMMUNE SYSTEM 07/24/13 Structure of murine IgG2a A20G2-Fab in complex with vaccinia antigen A33R at the resolution of 2.9 Angstroms MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus Matho, M.H., Schlossman, A.M., Zajonc, D.M. 2.9 X-RAY DIFFRACTION 0.282 0.234 False True IGHV5 IGKV1 Kappa 6.59e-11 -13.889525396748654 SPR TBD 1rzg A B 0 IMMUNE SYSTEM 12/24/03 Crystal structure of Human anti-HIV-1 GP120 reactive antibody 412d HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.251 0.201 False True IGHV1 IGKV1 Kappa None None None None None 7ldd I i 0 C protein NA glutamate receptor 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5x2n J K 0 C | D protein | protein NA | NA taste receptor, type 1, member 2a | taste receptor, type 1, member 3 SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-alanine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes | oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.2 X-RAY DIFFRACTION 0.244 0.195 False True IGHV1 IGKV3 Kappa None None None None None 1clo H L 0 IMMUNOGLOBULIN 05/01/96 ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7 MUS MUSCULUS mus musculus mus musculus Banfield, M.J., King, D.J., Mountain, A., Brady, R.L. 2.1 X-RAY DIFFRACTION unknown 0.212 False False IGHV7 IGKV4 Kappa None None None None None 5f3j D d 0 B protein duffy receptor IMMUNE SYSTEM 12/02/15 Crystal structure of DBP in complex with inhibitory monoclonal antibody 2D10 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus plasmodium vivax (strain salvador i) Chen, E., Salinas, N.D., Tolia, N.H. 4.001 X-RAY DIFFRACTION 0.300 0.267 True True unknown unknown unknown None None None None None 4gxv H L 0 IMMUNE SYSTEM 09/04/12 Crystal structure of anti-influenza virus antibody 1F1 HOMO SAPIENS homo sapiens homo sapiens Ekiert, D.C., Wilson, I.A. 1.449 X-RAY DIFFRACTION 0.207 0.181 False True IGHV3 IGLV1 Lambda None None None None None 3w9e A B 0 C protein envelope glycoprotein d VIRAL PROTEIN/IMMUNE SYSTEM 04/03/13 Structure of Human Monoclonal Antibody E317 Fab Complex with HSV-2 gD HOMO SAPIENS; HUMAN HERPESVIRUS 2 homo sapiens homo sapiens human herpesvirus 2 Lee, C.C., Lin, L.L., Wang, A.H.J. 2.3 X-RAY DIFFRACTION 0.255 0.203 False True IGHV1 IGKV3 Kappa None None None None None 3mnv B A 0 IMMUNE SYSTEM 04/22/10 Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment MUS MUSCULUS,HOMO SAPIENS mus musculus,homo sapiens mus musculus,homo sapiens Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 2.4 X-RAY DIFFRACTION 0.228 0.181 False True IGHV9 IGKV8 Kappa None None None None None 7lop B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/10/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.246 X-RAY DIFFRACTION 0.268 0.220 False True IGHV5 IGKV4 Kappa None None None None None 6vrl B C 0 A protein sodium-dependent serotonin transporter TRANSPORT PROTEIN 02/07/20 Cryo-EM structure of the wild-type human serotonin transporter complexed with I-paroxetine and 8B6 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Navratna, V., Yang, D. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV6 Kappa None None None None None 5x8l S N 0 D protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 03/03/17 PD-L1 in complex with atezolizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, H.T. 3.1 X-RAY DIFFRACTION 0.256 0.208 False True IGHV3 IGKV1 Kappa None None None None None 7mtb H L 3 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4jr9 H L 0 A protein nitrite extrusion protein 1 TRANSPORT PROTEIN/Immune System 03/21/13 Crystal structure of nitrate/nitrite exchanger NarK ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Zheng, H., Wisedchaisri, G., Gonen, T. 2.6 X-RAY DIFFRACTION 0.261 0.229 False False IGHV9 IGKV19 Kappa None None None None None 3hae T S 0 P | R protein | peptide NA | NA hla class i histocompatibility antigen, a-2 alpha chain | nyeso-1 peptide IMMUNE SYSTEM 05/01/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E. 2.9 X-RAY DIFFRACTION 0.283 0.201 False True IGHV3 IGLV2 Lambda 4.60e-08 -10 SPR 19307587 5uel H L 0 IMMUNE SYSTEM 01/02/17 Crystal structure of 354NC102 Fab HOMO SAPIENS homo sapiens homo sapiens Sievers, S.A., Gristick, H.B., Bjorkman, P.J. 1.6 X-RAY DIFFRACTION 0.201 0.177 False True unknown IGKV3 Kappa None None None None None 2wub H L 0 A protein hepatocyte growth factor activator long chain HYDROLASE/IMMUNE SYSTEM 10/01/09 Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ganesan, R., Eigenbrot, C., Shia, S., , 2.9 X-RAY DIFFRACTION 0.275 0.216 False True IGHV3 IGKV1 Kappa 1.50e-07 -9.3 SPR 25 20004165 7rsn F K 0 G protein NA amc018 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/11/21 AMC018 SOSIP.v4.2 in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.49 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7jxd A B 0 NA NA NA NA IMMUNE SYSTEM 08/27/20 Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology HOMO SAPIENS homo sapiens homo sapiens Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.5 X-RAY DIFFRACTION 0.259 0.203 False True IGHV3 IGLV6 Lambda None None None None None 7sc1 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, R40-1G8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fan, C., Bjorkman, P.J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3qxw A NA 0 IMMUNE SYSTEM 03/02/11 Free structure of an anti-methotrexate CDR1-4 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.85 X-RAY DIFFRACTION 0.238 0.189 False True IGHV1 None None None None None 7kbi C NA 0 A | B protein | protein NA | NA ricin chain a | ricin chain b TOXIN 10/02/20 Ricin bound to VHH antibody V5E1 VICUGNA PACOS; RICINUS COMMUNIS vicugna pacos ricinus communis | ricinus communis Rudolph, M.J. 3.049 X-RAY DIFFRACTION 0.274 0.237 False True IGHV1 NA NA None None None None None 4jm2 D C 0 E protein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/13/13 Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, L., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.285 0.238 False True IGHV1 IGKV3 Kappa None None None None None 7joo H L 0 C protein NA inducible t-cell costimulator IMMUNE SYSTEM 08/06/20 Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain LAMA GLAMA; HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rujas, E., Sicard, T., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.297 0.241 False True IGHV3 IGKV3 Kappa None None None None None 2bdn H L 0 A protein small inducible cytokine a2 immune system 10/20/05 Crystal structure of human MCP-1 bound to a blocking antibody, 11K2 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Boriack-Sjodin, P.A., Rushe, M., Reid, C., Jarpe, M, van Vlijmen, H, Bailly, V. 2.53 X-RAY DIFFRACTION 0.277 0.219 False True IGHV14 IGKV13 Kappa 4.60e-12 -15.46 Other 25 16682434 5vnw D NA 0 A protein serum albumin TRANSPORT PROTEIN/DE NOVO PROTEIN 05/01/17 Crystal structure of Nb.b201 bound to human serum albumin HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens McMahon, C., Kruse, A.C. 2.6 X-RAY DIFFRACTION 0.256 0.221 False True IGHV1 None None None None None 7wd0 a b 0 A protein NA heavy chain of s5d2 fab VIRAL PROTEIN 12/20/21 SARS-CoV-2 Beta spike in complex with two S5D2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.3 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 7vsw J I 0 NA NA NA NA BIOSYNTHETIC PROTEIN 10/27/21 Crystal structure of a Fab-like fragment of anti-mesothelin antibody HOMO SAPIENS homo sapiens homo sapiens Yang, Z., Ying, T. 3.0 X-RAY DIFFRACTION 0.253 0.217 False True IGHV4 IGKV1 Kappa None None None None None 7kkk B NA 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/20 SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7rkn D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/22/21 Structure of CX3CL1-US28-Gi-scFv16 in OC-state HOMO SAPIENS; MUS MUSCULUS; HUMAN CYTOMEGALOVIRUS mus musculus homo sapiens | homo sapiens Tsutsumi, N., Qu, Q., Jude, K.M., Skiniotis, G., Garcia, K.C. 3.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6mty H L 0 IMMUNE SYSTEM 10/22/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 isolated following ZPIV vaccination HOMO SAPIENS homo sapiens homo sapiens Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 2.951 X-RAY DIFFRACTION 0.251 0.217 False True IGHV4 IGLV1 Lambda None None None None None 7n4n D NA 0 A protein NA beta-secretase 2 HYDROLASE/INHIBITOR 06/04/21 BACE-2 in complex with ligand 36 HOMO SAPIENS homo sapiens homo sapiens Shaffer, P.L. 1.41 X-RAY DIFFRACTION 0.207 0.163 False True IGHV3 NA NA None None None None None 7qiv C NA 0 B | A protein | protein NA | NA complement c3b alpha' chain | complement c3 beta chain IMMUNE SYSTEM 12/16/21 Structure of human C3b in complex with the EWE nanobody LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Pedersen, H., Andersen, G.R. 2.8 X-RAY DIFFRACTION 0.275 0.235 False True IGHV1 NA NA None None None None None 5cgy C D 0 IMMUNE SYSTEM 07/09/15 Fab fragment of Chikungunya virus neutralizing human monoclonal antibody 4J21 HOMO SAPIENS homo sapiens homo sapiens Long, F., Crowe, J.E., Rossmann, M.G. 2.07 X-RAY DIFFRACTION 0.216 0.168 False False IGHV7 IGLV1 Lambda None None None None None 1fe8 J N 0 C protein von willebrand factor IMMUNE SYSTEM 07/21/00 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Bouma, B., Huizinga, E.G., Schiphorst, M.E., Sixma, J.J., Kroon, J., Gros, P. 2.03 X-RAY DIFFRACTION 0.264 0.227 False False IGHV2 IGKV10 Kappa 2e-06 -7.7747861441417445 Unknown TBD 7pg8 X V 0 O protein NA ion transport protein,voltage-gated sodium channel MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-ANT05 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII MLHE-1; RUEGERIA POMEROYI DSS-3 homo sapiens homo sapiens alkalilimnicola ehrlichii mlhe-1, ruegeriapomeroyi dss-3 Lolicato, M., Arrigoni, C. 4.5 X-RAY DIFFRACTION 0.352 0.303 False True IGHV3 IGKV1 Kappa None None None None None 6p3s A B 0 L protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 4kht H L 0 A protein gp41 helix immune system 05/01/13 Triple helix bundle of GP41 complexed with fab 8066 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Li, M., Gustchina, A,, Wlodawer, A. 2.817 X-RAY DIFFRACTION 0.266 0.215 False False IGHV1 IGLV3 Lambda 4.3000000000000005e-09 -11.413991208339995 ITC TBD 5tjd H L 0 IMMUNE SYSTEM 10/04/16 Computer-based rational design of improved functionality for antibody catalysts toward organophosphorus compounds HOMO SAPIENS homo sapiens homo sapiens Chatziefthimiou, S., Stepanova, A., Smirnov, I., Gabibov, A., Wilmanns, M. 2.1 X-RAY DIFFRACTION 0.249 0.196 False True IGHV4 IGLV1 Lambda None None None None None 3dv6 B A 0 B carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/18/08 Crystal structure of SAG506-01, tetragonal, crystal 2 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.303 0.229 False True IGHV7 IGKV8 Kappa None None None None None 3o2v H L 0 IMMUNE SYSTEM 07/22/10 Crystal structure of 1E9 PheL89Ser/LeuH47Trp/MetH100bPhe, an engineered Diels-Alderase Fab with modified specificity and catalytic activity MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Verdino, P., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.219 0.192 False True IGHV9 IGKV1 Kappa None None None None None 1igi H L 0 IMMUNOGLOBULIN 02/19/93 26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY MUS MUSCULUS mus musculus mus musculus Jeffrey, P.D., Sheriff, S. 2.7 X-RAY DIFFRACTION unknown 0.177 False True IGHV1 IGKV1 Kappa None None None None None 3gb7 A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 02/18/09 Potassium Channel KcsA-Fab complex in Li+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Thompson, A.N., Ilsoo, K., Panosian, T.D., Iverson, T.M., Allen, T.W., Nimigean, C.M. 2.85 X-RAY DIFFRACTION 0.285 0.239 False False IGHV1 IGKV5 Kappa None None None None None 7ey5 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/29/21 Local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-771 Fab and BD-821 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z.Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6b70 C D 0 A protein insulin HYDROLASE/IMMUNE SYSTEM/HORMONE 10/03/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 3.7 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 5wk3 U T 0 C protein c-c motif chemokine 17 IMMUNE SYSTEM 07/24/17 CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.231 0.180 False True IGHV5 IGKV4 Kappa None None None None None 5ye4 A B 0 E peptide di-acetylated histone h4 NUCLEAR PROTEIN 09/15/17 Crystal structure of the complex of di-acetylated histone H4 and 1A9D7 Fab fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Matsuda, T., Ito, T., Wakamori, M., Umehara, T. 1.799 X-RAY DIFFRACTION 0.224 0.194 False True IGHV9 IGKV19 Kappa None None None None None 5vaq B NA 0 A protein beta-klotho SIGNALING PROTEIN 03/27/17 Crystal Structure of Beta-Klotho in Complex with FGF21CT HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens Lee, S., Schlessinger, J. 2.606 X-RAY DIFFRACTION 0.229 0.191 False True IGHV1 None None None None None 2ltq C B 8 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 3dur D C 0 D carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 07/17/08 Crystal structure of SAG173-04 MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Gerstenbruch, S., Kosma, P., Muller-Loennies, S., Brade, H., Evans, S.V. 1.86 X-RAY DIFFRACTION 0.247 0.178 False True IGHV7 IGKV8 Kappa None None None None None 6ea7 Q R 0 VIRAL PROTEIN/immune system 08/02/18 Structure of EBOV GPcl in complex with the pan-ebolavirus mAb ADI-15878 ZAIRE EBOLAVIRUS; EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens West, B.R., Moyer, C.L., King, L.B., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O. 4.25 X-RAY DIFFRACTION 0.324 0.280 False True IGHV3 IGKV1 Kappa None None None None None 1lil NA A 0 IMMUNOGLOBULIN 05/13/96 BENCE JONES PROTEIN CLE, A LAMBDA III IMMUNOGLOBULIN LIGHT-CHAIN DIMER HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.65 X-RAY DIFFRACTION 0.340 0.190 False False IGLV3 Lambda None None None None None 4hkb J N 0 IMMUNE SYSTEM 10/15/12 CH67 Fab (unbound) from the CH65-67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 3.6 X-RAY DIFFRACTION 0.306 0.258 False True IGHV1 IGLV3 Lambda None None None None None 6n16 K J 0 G peptide hiv fusion peptide (512-519) IMMUNE SYSTEM 11/08/18 Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-b.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.302 X-RAY DIFFRACTION 0.274 0.222 False True IGHV4 IGKV2 Kappa None None None None None 7rth P O 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 1k4d A B 0 C protein potassium channel kcsa MEMBRANE PROTEIN 10/07/01 Potassium Channel KcsA-Fab complex in low concentration of K+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R. 2.3 X-RAY DIFFRACTION 0.235 0.218 False False IGHV1 IGKV5 Kappa None None None None None 6m3b C B 0 A protein NA vitamin k-dependent protein c heavy chain BLOOD CLOTTING/IMMUNE SYSTEM 03/03/20 hAPC-c25k23 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, X., Li, L., Zhao, X., Egner, U. 2.2 X-RAY DIFFRACTION 0.248 0.218 False True IGHV3 IGLV1 Lambda None None None None None 6vep U V 0 W protein insulin receptor subunit alpha HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM 06/03/20 Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G.T. 2.9 X-RAY DIFFRACTION 0.225 0.193 False True IGHV2 IGKV8 Kappa None None None None None 7jix H L 0 A protein NA hemagglutinin ha1 chain Viral protein/IMMUNE SYSTEM 07/23/20 Murine antibody that engages the influenza hemagglutinin receptor binding site INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006 (EGG PASSAGE)(H1N1)); INFLUENZA A VIRUS (A/MEXICO/UASLP-006/2008(H1N1)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/solomon islands/3/2006(egg passage)(h1n1)) Bajic, G., Schmidt, A.G. 3.901 X-RAY DIFFRACTION 0.255 0.215 False True IGHV1 IGKV3 Kappa None None None None None 5t5n I H 0 A protein bestrophin-1 (best1) MEMBRANE PROTEIN 08/31/16 Calcium-activated chloride channel bestrophin-1 (BEST1), triple mutant: I76A, F80A, F84A; in complex with an Fab antibody fragment, chloride, and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Long, S.B., Vaisey, G. 3.1 X-RAY DIFFRACTION 0.243 0.218 False False IGHV1 IGKV12 Kappa None None None None None 7a4d B NA 0 F peptide NA aph coiled-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with nanobodies Nb28 and Nb30 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 2.694 X-RAY DIFFRACTION 0.223 0.177 False True IGHV1 NA NA None None None None None 6opp N O 0 J protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 Asymmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6x04 B NA 0 A protein NA nucleoporin nup133 STRUCTURAL PROTEIN 05/15/20 Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN5 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 2.68 X-RAY DIFFRACTION 0.261 0.244 False True IGHV1 NA NA None None None None None 7wed H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv347 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6x3x K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 2.92 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 7tn0 H G 0 I protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/20/22 SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., McCallum, M., Veesler, D., Nix, J.C., Croll, T.I., Dillen, J.R., Czudnochowski, N. 2.85 X-RAY DIFFRACTION 0.268 0.230 False True IGHV3 IGKV1 Kappa None None None None None 7so9 C B 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.2 delta variant + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4lu5 H L 0 B protein a33r IMMUNE SYSTEM 07/24/13 Structure of murine IgG2a A20G2-Fab in complex with vaccinia antigen A33R at the resolution of 2.9 Angstroms MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus Matho, M.H., Schlossman, A.M., Zajonc, D.M. 2.9 X-RAY DIFFRACTION 0.282 0.234 False True IGHV5 IGKV1 Kappa 6.59e-11 -13.889525396748654 SPR TBD 5hdb H L 0 A protein NA integrin alpha-iib MEMBRANE PROTEIN/IMMUNE SYSTEM 01/05/16 Integrin alphaIIbbeta3 in complex with Ro-435054 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lin, F.Y. 2.7012 X-RAY DIFFRACTION 0.238 0.212 False True IGHV14 IGKV14 Kappa None None None None None 7vmu A a 0 B protein NA spike protein s1 IMMUNE SYSTEM 10/09/21 Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y., Wang, W., Jiao, P., Yang, H., Rao, Z., Cheng, G. 2.89 X-RAY DIFFRACTION 0.273 0.241 True True unknown unknown unknown None None None None None 6qtl E NA 0 E Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 3bz4 H G 0 H carbohydrate RAM polysaccharide IMMUNE SYSTEM 01/17/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag decasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.230 0.176 False False IGHV6 IGKV2 Kappa None None None None None 2uyl B A 0 IMMUNE SYSTEM 04/10/07 Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1 MUS MUSCULUS mus musculus mus musculus Ahmed, F., Haouz, A., Nato, F., Fournier, J.M., Alzari, P.M. 2.5 X-RAY DIFFRACTION 0.257 0.211 False False IGHV1 IGKV1 Kappa None None None None None 7jhg N NA 0 NA NA NA NA TRANSFERASE/IMMUNE SYSTEM 07/20/20 Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody HOMO SAPIENS; ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct Yan, Y., Murkherjee, S., Zhou, X.E., Xu, T.H., Xu, H.E., Kossiakoff, A.A., Melcher, K. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3q3g H F 0 I protein integrin alpha-m IMMUNE SYSTEM/CELL ADHESION 12/21/10 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 2.7 X-RAY DIFFRACTION 0.244 0.211 False False IGHV14 IGKV8 Kappa 4.97e-09 -11.32 SPR 25 22095715 5muh NA B 0 IMMUNE SYSTEM 01/13/17 Crystal structure of an amyloidogenic light chain dimer H7 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Maritan, M., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.65 X-RAY DIFFRACTION 0.266 0.205 False True IGLV1 Lambda None None None None None 7cbp D E 0 K | Q protein | protein NA | NA envelope protein e | envelope protein e VIRUS 06/13/20 CryoEM structure of Zika virus with Fab at 4.1 Angstrom HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus | zika virus Tyagi, A., Ahmed, T., Shi, J., Bhushan, S. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6v7z F NA 0 A | B protein | protein NA | NA antigen-presenting glycoprotein cd1d | beta-2-microglobulin IMMUNE SYSTEM 12/10/19 Human CD1d presenting alpha-Galactosylceramide in complex with VHH nanobody 1D22 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Shahine, A., Rossjohn, J. 2.75 X-RAY DIFFRACTION 0.252 0.186 False True IGHV1 NA NA None None None None None 5weq B A 0 IMMUNE SYSTEM 07/10/17 The crystal structure of a MR78 mutant HOMO SAPIENS homo sapiens homo sapiens Dong, J., Williamson, L.E., Crowe, J.E. 2.0 X-RAY DIFFRACTION 0.215 0.186 False True IGHV4 IGKV1 Kappa None None None None None 5w9o E F 0 D protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.5 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7d00 H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with FabP5A-1B8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6z2m H L 0 E protein spike glycoprotein VIRAL PROTEIN 06/03/20 H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Naismith, J.H., Ren, J., Zhou, D., Zhao, Y., Stuart, D.I. 2.71 X-RAY DIFFRACTION 0.241 0.198 False True IGHV5 IGKV4 Kappa None None None None None 2kqn NA A 14 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6tcp B A 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.5 X-RAY DIFFRACTION 0.239 0.212 False True IGHV3 IGKV1 Kappa None None None None None 4lsp H L 0 G protein hiv-1 clade a/e strain 93th057 gp120 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E gp120 93TH057 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.15 X-RAY DIFFRACTION 0.214 0.180 False True unknown IGKV1 Kappa None None None None None 4fqr u v 0 U protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 2jix D G 0 E protein erythropoietin receptor RECEPTOR/IMMUNE SYSTEM 07/02/07 Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor ESCHERICHIA COLI; HOMO SAPIENS homo sapiens Liu, Z., Stoll, V.S., DeVries, P., Jakob, C.G., Xie, N., Simmer, R.L., Lacy, S.E., Egan, D.A., Harlan, J.E., Lesniewski, R.R., Reilly, E.B. 3.2 X-RAY DIFFRACTION 0.323 0.257 False True IGHV4 IGKV1 Kappa 3.00e-08 -10.26 SPR 17620453 1fh5 H L 0 IMMUNE SYSTEM 07/31/00 CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33 HOMO SAPIENS homo sapiens homo sapiens Augustine, J.G., de la Calle, A., Knarr, G., Buchner, J., Frederick, C.A. 2.9 X-RAY DIFFRACTION 0.243 0.198 False False IGHV5 IGKV5 Kappa None None None None None 5w1m F E 0 Q protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 MACV GP1 CR1-07 Fab complex HOMO SAPIENS; MACHUPO VIRUS homo sapiens homo sapiens machupo virus Raymond, D.D., Clark, L.E., Abraham, J. 3.91 X-RAY DIFFRACTION 0.264 0.248 False True IGHV3 IGKV4 Kappa 1.63e-08 -10.624477030127814 SPR TBD 7n4l H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2125. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 3.601 X-RAY DIFFRACTION 0.329 0.262 False True IGHV3 IGKV1 Kappa None None None None None 6cue 5 6 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6wdt H L 0 A | C | B protein | protein | protein NA | NA | NA viral protein 1 | viral protein 3 | viral protein 2 VIRUS/IMMUNE SYSTEM 04/01/20 Enterovirus D68 in complex with human monoclonal antibody EV68-228 ENTEROVIRUS D68; HOMO SAPIENS homo sapiens homo sapiens enterovirus d68 | enterovirus d68 | enterovirus d68 Fu, J., Vogt, M.R., Klose, T., Crowe, J.E., Rossmann, M.G., Kuhn, R.J., Center for Structural Genomics of Infectious Diseases (CSGID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5do2 H L 0 A protein s protein VIRAL PROTEIN/IMMUNE SYSTEM 09/10/15 Complex structure of MERS-RBD bound with 4C2 antibody MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome coronavirus Li, Y., Wan, Y., Liu, P., Zhao, J., Lu, G., Qi, J., Wang, Q., Lu, X., Wu, Y., Liu, W., Yuen, K.Y., Perlman, S., Gao, G.F., Yan, J. 2.409 X-RAY DIFFRACTION 0.289 0.245 False False IGHV5 IGKV10 Kappa 1.6200000000000002e-07 -9.263879005639293 SPR TBD 7tat H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/21 SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (two receptor-binding domains open) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 7lvw H NA 0 E protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/26/21 Structure of RSV F in Complex with VHH Cl184 RESPIRATORY SYNCYTIAL VIRUS; LAMA GLAMA lama glama respiratory syncytial virus Hsieh, C.-L., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.230 0.201 False True IGHV1 NA NA None None None None None 6rvc E NA 0 B protein protein patched homolog 1 MEMBRANE PROTEIN 05/31/19 Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Rudolf, A.F., Kowatsch, C., El Omari, K., Malinauskas, T., Kinnebrew, M., Ansell, T.B., Bishop, B., Pardon, E., Schwab, R.A., Qian, M., Duman, R., Covey, D.F., Steyaert, J., Wagner, A., Sansom, M.S.P., Rohatgi, R., Siebold, C. 2.2 X-RAY DIFFRACTION 0.241 0.204 False True IGHV1 None None None None None 4z5r U T 0 I protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 2fx7 H L 0 P peptide fragment of hiv glycoprotein (gp41) IMMUNE SYSTEM 02/03/06 Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a 16-residue peptide encompassing the 4e10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Brunel, F.M., Ferguson, S., Burton, D.R., Dawson, P.E., Wilson, I.A. 1.76 X-RAY DIFFRACTION 0.222 0.202 False True IGHV1 IGKV3 Kappa 2.00e-08 -10.5 SPR 17125793 7ben H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253 and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.5 X-RAY DIFFRACTION 0.282 0.240 False True IGHV1 IGKV3 Kappa None None None None None 2otu F E 0 R peptide peptide antigen IMMUNE SYSTEM 02/09/07 Crystal structure of Fv polyglutamine complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Li, P. 1.68 X-RAY DIFFRACTION 0.214 0.200 False True IGHV5 IGLV3 Lambda None None None None None 7dnl H L 0 B | A protein | protein NA | NA major capsid protein l1 | major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 12/09/20 2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of A4B4 HUMAN PAPILLOMAVIRUS TYPE 58; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 58 | human papillomavirus type 58 He, M.Z., Chi, X., Zha, Z.H., Zheng, Q.B., Gu, Y., Li, S.W., Xia, N.S. 4.19 ELECTRON MICROSCOPY NA NA False False IGHV8 IGKV8 Kappa None None None None None 6x96 E F 0 C protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 10A fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5xcx A B 0 IMMUNE SYSTEM 03/23/17 Crystal structure of TS2/16 Fv-clasp fragment MUS MUSCULUS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Arimori, T., Takagi, J. 2.04 X-RAY DIFFRACTION 0.227 0.194 False True IGHV5 IGKV4 Kappa None None None None None 6jb8 A NA 0 B protein lysozyme c IMMUNE SYSTEM/HYDROLASE 01/25/19 Crystal structure of nanobody D3-L11 in complex with hen egg-white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus Caaveiro, J.M.M., Tamura, H., Akiba, H., Tsumoto, K. 1.65 X-RAY DIFFRACTION 0.207 0.169 False True IGHV1 None None None None None 6e64 A B 0 IMMUNE SYSTEM 07/23/18 Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody 85RF45.1 RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Kundu, P., Semesi, A., Julien, J.P. 3.15 X-RAY DIFFRACTION 0.279 0.246 False True IGHV5 IGLV3 Lambda None None None None None 4ywg I M 0 Q protein scaffold hiv-1 gp120 v1v2 region derived from strain zm109 Viral protein/Immune system 03/20/15 Crystal structure of 830A in complex with V1V2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Pan, R., Kong, X. 2.998 X-RAY DIFFRACTION 0.296 0.219 False True IGHV4 IGKV3 Kappa None None None None None 4rfn H L 0 G protein hiv-1 clade a/e 93th057 (h375s) gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/26/14 Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Gohain, N., Tolbert, W.D., Pazgier, M. 3.21 X-RAY DIFFRACTION 0.332 0.273 False True IGHV4 IGLV1 Lambda None None None None None 5eu7 F D 0 B protein integrase VIRAL PROTEIN 11/18/15 Crystal structure of HIV-1 integrase catalytic core in complex with Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Galilee, M., Griner, S.L., Stroud, R.M., Alian, A. 2.64 X-RAY DIFFRACTION 0.233 0.181 False True IGHV3 IGKV1 Kappa None None None None None 7rw2 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/19/21 Cryo-EM structure of NTD-directed neutralizing antibody 5-7 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3r0m A NA 0 Immune system 03/08/11 Crystal structure of anti-HIV llama VHH antibody A12 LAMA GLAMA lama glama Chen, L., McLellan, J.S., Kwon, Y.D., Schmidt, S., Wu, X., Zhou, T., Yang, Y., Zhang, B., Forsman, A., Weiss, R.A., Verrips, T., Mascola, J., Kwong, P.D. 1.5 X-RAY DIFFRACTION 0.217 0.193 False True IGHV1 None None None None None 6h3t H L 0 A protein envelopment polyprotein VIRAL PROTEIN 07/19/18 Schmallenberg Virus Glycoprotein Gc Head Domain in Complex with scFv 1C11 MUS MUSCULUS; BOVINE SCHMALLENBERG VIRUS mus musculus mus musculus bovine schmallenberg virus Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A. 2.836 X-RAY DIFFRACTION 0.262 0.213 False True IGHV1 IGKV8 Kappa None None None None None 6njm L K 0 B protein glutamate receptor 2 MEMBRANE PROTEIN/Immune System 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.5 ELECTRON MICROSCOPY False True IGHV2 IGKV10 Kappa None None None None None 6iyn A NA 7 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7r9d N NA 0 NA NA NA NA PROTEIN BINDING 06/29/21 Crystal structure of Nb_0 in complex with Fab_8D3 MUS MUSCULUS; VICUGNA PACOS vicugna pacos Wu, X.D., Rapoport, T.A. 1.83 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 NA NA None None None None None 6xbm S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/06/20 Structure of human SMO-Gi complex with 24(S),25-EC HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Qi, X., Long, T., Li, X. 3.15 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ben A B 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253 and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.5 X-RAY DIFFRACTION 0.282 0.240 False True IGHV3 IGKV1 Kappa None None None None None 7qji C NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.1 X-RAY DIFFRACTION 0.316 0.267 False True IGHV1 NA NA None None None None None 5f9o H L 0 G protein clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 12/10/15 Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.09 in complex with HIV-1 clade A/E 93TH057 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.86 X-RAY DIFFRACTION 0.221 0.204 False True unknown IGKV3 Kappa None None None None None 3u79 NA H 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 7tpr G NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/25/22 Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS DROMEDARIUS camelus dromedarius severe acute respiratory syndrome coronavirus2 Butay, K.J., Zhu, J., Dandey, V.P., Hong, J., Kwon, H.J., Chen, C.Z., Duan, Z., Li, D., Ren, H., Liang, T., Martin, N., Esposito, D., Ortega-Rodriguez, U., Xu, M., Xie, H., Ho, M., Cachau, R., Borgnia, M.J. 2.39 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7p79 H NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybodyb#15 in a 1up/1up-out/1down conformation. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6xlq K L 0 J protein NA butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 06/29/20 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the CTX-2026 Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payne, K.K., Mine, J.A., Biswas, S., Chaurio, R.A., Perales-Puchalt, A., Anadon, C.M., Costich, T.L., Harro, C.M., Walrath, J., Ming, Q., Tcyganov, E., Buras, A.L., Rigolizzo, K.E., Mandal, G., Lajoie, J., Ophir, M., Tchou, J., Marchion, D., Luca, V.C., Bobrowicz, P., McLaughlin, B., Eskiocak, U., Schmidt, M., Cubillos-Ruiz, J.R., Rodriguez, P.C., Gabrilovich, D.I., Conejo-Garcia, J.R. 3.0 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV1 Kappa None None None None None 7rkv E F 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C118 (State 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Jette, C.A., Bjorkman, P.J. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 6hig H L 0 B protein programmed cell death protein 1 IMMUNE SYSTEM 08/29/18 hPD-1/NBO1a Fab complex MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Loredo-Varela, J.L., Fenwick, C., Pantaleo, G., Weissenhorn, W. 2.2 X-RAY DIFFRACTION 0.270 0.215 False True IGHV7 IGKV1 Kappa None None None None None 6pbv B A 0 G peptide junctional peptide IMMUNE SYSTEM 06/14/19 Crystal structure of Fab668 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Oyen, D., Wilson, I.A. 1.566 X-RAY DIFFRACTION 0.212 0.177 False True IGHV1 IGLV2 Lambda None None None None None 5ir1 D C 0 IMMUNE SYSTEM 03/11/16 Cetuximab Fab in complex with 3-bromophenylalanine meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.482 X-RAY DIFFRACTION 0.215 0.163 False True IGHV2 IGKV5 Kappa None None None None None 2cgr H L 0 H Hapten GAS ? IMMUNOGLOBULIN 11/23/93 LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB MUS MUSCULUS mus musculus mus musculus mus musculus Guddat, L.W., Shan, L., Edmundson, A.B. 2.2 X-RAY DIFFRACTION unknown 0.214 False True IGHV1 IGKV1 Kappa 5.30e-08 -9.92 Other 8232332 1tzg H L 0 P peptide envelope polyprotein gp160 IMMUNE SYSTEM 07/09/04 Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Zwick, M.B., Stanfield, R.L., Kunert, R., Binley, J.M., Katinger, H., Burton, D.R., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.260 0.217 False True IGHV1 IGKV3 Kappa None None None None None 1ott C D 0 A protein voltage-gated clc-type chloride channel eric MEMBRANE PROTEIN 03/23/03 Structure of the Escherichia coli ClC Chloride channel E148A mutant and Fab Complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Dutzler, R., Campbell, E.B., MacKinnon, R. 3.0 X-RAY DIFFRACTION 0.338 0.296 False False IGHV4 IGKV4 Kappa None None None None None 6tcq H L 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Ser81Arg and Gln83Arg light chain mutant HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.05 X-RAY DIFFRACTION 0.221 0.174 False True IGHV3 IGKV1 Kappa None None None None None 7x6o C D 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/07/22 Cryo-EM structure of H1 hemagglutinin from A/Washington/05/2011 in complex with a neutralizing antibody 28-12 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Cong, Y., Liu, C.X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4utb H L 0 A protein envelope glycoprotein e IMMUNE SYSTEM/VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Rouvinski, A., Guardado-Calvo, P., Barba-Spaeth, G., Duquerroy, S., Vaney, M.C., Rey, F.A. 3.85 X-RAY DIFFRACTION 0.2567 0.2297 False True IGHV3 IGLV2 Lambda None None None None None 6p4b H L 0 C protein lysozyme c HYDROLASE/IMMUNE SYSTEM 05/27/20 HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S) MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.244 0.203 False True IGHV3 IGKV5 Kappa None None None None None 6mtx H L 0 IMMUNE SYSTEM 10/22/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ1 isolated following ZPIV vaccination HOMO SAPIENS homo sapiens homo sapiens Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 2.051 X-RAY DIFFRACTION 0.210 0.176 False True IGHV4 IGLV1 Lambda None None None None None 6zqk D NA 0 NA NA NA NA ANTITUMOR PROTEIN 07/09/20 HER2-binding scFv-Fab fusion 841 MUS MUSCULUS mus musculus Kast, F., Schwill, M., Stueber, J.C., Pfundstein, S., Nagy-Davidescu, G., Monne Rodriguez, J.M., Seehusen, F., Richter, C.P., Honegger, A., Hartmann, K.P., Weber, T.G., Kroener, F., Ernst, P., Piehler, J., Plueckthun, A. 2.2 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 NA NA None None None None None 6apb H L 0 C | A protein | protein NA | NA fusion glycoprotein f0,fusion glycoprotein f0 | fusion glycoprotein f0,fusion glycoprotein f0 IMMUNE SYSTEM 08/17/17 Crystal Structure of Non-Neutralizing Infant Antibody ADI-14359 in Complex with Postfusion RSV F Glycoprotein HUMAN RESPIRATORY SYNCYTIAL VIRUS; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus | human respiratory syncytial virus Gilman, M.S.A., McLellan, J.S. 3.0 X-RAY DIFFRACTION 0.255 0.222 False True IGHV2 IGKV1 Kappa None None None None None 7e9n Y X 0 C protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/04/21 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7mw3 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4r7n O P 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 6o3d H L 0 IMMUNE SYSTEM 02/26/19 Crystal structure of the unbound Fab fragment of the human HIV-1 neutralizing antibody PGZL1. HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Wilson, I.A. 1.402 X-RAY DIFFRACTION 0.181 0.146 False True IGHV1 IGKV3 Kappa None None None None None 4xwo E F 0 B protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 6ban D C 0 N protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/14/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.95 X-RAY DIFFRACTION 0.196 0.160 False True IGHV1 IGKV1 Kappa None None None None None 7fat B NA 0 A protein NA spike protein s1 STRUCTURAL PROTEIN 07/07/21 Structure Determination of the RBD-NB1A7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS BACTRIANUS camelus bactrianus severe acute respiratory syndrome coronavirus2 Geng, Y., Shi, Z.Z., Li, X.Y., Wang, L., Sun, Z.C., Zhang, H.W., Chen, X.C. 1.99 X-RAY DIFFRACTION 0.242 0.193 False True IGHV1 NA NA None None None None None 6mqr H L 0 A peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 10/10/18 Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex with FP (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.45 X-RAY DIFFRACTION 0.209 0.175 False True IGHV4 IGKV1 Kappa None None None None None 6wer E F 0 B protein NA non-structural protein 1 VIRAL PROTEIN 04/02/20 DENV2 NS1 in complex with neutralizing 2B7 Fab fragment DENGUE VIRUS 2; MUS MUSCULUS mus musculus mus musculus dengue virus 2 Akey, D.L., Smith, J.L. 3.96 X-RAY DIFFRACTION 0.311 0.276 False False IGHV1 IGKV3 Kappa None None None None None 1fai H L 0 IMMUNOGLOBULIN 05/27/92 THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY MUS MUSCULUS mus musculus mus musculus Lascombe, M.B., Alzari, P.M., Poljak, R.J., Nisonoff, A. 2.7 X-RAY DIFFRACTION unknown 0.189 False True IGHV1 IGKV10 Kappa None None None None None 1jnh B A 0 B Hapten ECO ESTRADIOL-6 CARBOXYL-METHYL-OXIME IMMUNE SYSTEM 07/24/01 Crystal Structure of Fab-Estradiol Complexes MUS MUSCULUS mus musculus mus musculus mus musculus Monnet, C., Bettsworth, F., Stura, E.A., Le Du, M.-H., Menez, R., Derrien, L., Zinn-Justin, S., Gilquin, B., Sibai, G., Battail-Poirot, N., Jolivet, M., Menez, A., Arnaud, M., Ducancel, F., Charbonnier, J.B. 2.85 X-RAY DIFFRACTION 0.253 0.198 False False IGHV1 IGLV1 Lambda None None None None None 6h7m C NA 0 A protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; ESCHERICHIA COLI meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.76 X-RAY DIFFRACTION 0.285 0.265 False True IGHV1 None None None None None 7lvu C NA 0 NA NA NA NA IMMUNE SYSTEM 02/26/21 Structure of RSV F-directed VHH Cl184 LAMA GLAMA lama glama Hsieh, C.-L., McLellan, J.S. 1.94 X-RAY DIFFRACTION 0.233 0.208 False True IGHV1 NA NA None None None None None 7whk H NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2kh2 B b 16 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6ssi F NA 0 A protein cys-loop ligand-gated ion channel TRANSPORT PROTEIN 09/07/19 Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J. 2.59 X-RAY DIFFRACTION 0.246 0.230 False True IGHV1 None None None None None 5sv3 C NA 0 D protein ricin TOXIN 08/04/16 RTA1-33/44-198 (RVEC) bound to Single Domain Antibody A3C8 LAMA GLAMA; RICINUS COMMUNIS lama glama ricinus communis Compton, J.R., Legler, P.M. 2.73 X-RAY DIFFRACTION 0.267 0.226 False True IGHV1 6.27e-10 -12.554773363845591 SPR TBD 7tyi N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/13/22 Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6ddv B A 0 C protein mhc class i chain-related protein a IMMUNE SYSTEM 05/10/18 Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Matsumoto, M.L. 2.05 X-RAY DIFFRACTION 0.275 0.223 False True IGHV1 IGKV1 Kappa 5.78e-09 -11.238741254569952 ITC TBD 3f58 H L 0 P peptide protein (cyclic peptide (gp120)) IMMUNE SYSTEM 10/23/98 IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 12-RESIDUE CYCLIC PEPTIDE (INCLUDING RESIDUES 315-324 OF HIV-1 GP120 (MN ISOLATE); H315S MUTATION MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Stanfield, R.L., Cabezas, E., Satterthwait, A.C., Stura, E.A., Profy, A.T., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.200 False False IGHV3 IGKV3 Kappa None None None None None 7sfw O P 0 E protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 (focus refine of the asymmetric unit) VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 5y80 B NA 0 A protein cyclin-g-associated kinase TRANSFERASE/IMMUNE SYSTEM 08/18/17 Complex structure of cyclin G-associated kinase with gefitinib HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Ohbayashi, N., Murayama, K., Kato-Murayama, M., Shirouzu, M. 2.5 X-RAY DIFFRACTION 0.282 0.230 False True IGHV3 1.6200000000000002e-09 -11.9923671844598 Unknown TBD 1rzi B A 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 7k93 G g 0 B protein NA non-structural protein 1 VIRAL PROTEIN 09/28/20 DENV2 NS1 in complex with neutralizing 2B7 single chain Fab variable region (scFv) DENGUE VIRUS 2; MUS MUSCULUS mus musculus dengue virus 2 Akey, D.L., Smith, J.L. 2.89 X-RAY DIFFRACTION 0.269 0.223 True True unknown unknown unknown None None None None None 2fjf B A 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 7r8o H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C548 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 DeLaitsch, A.T., Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV9 Lambda None None None None None 3hr5 J Q 0 V peptide m1prime-derived peptide IMMUNE SYSTEM 06/08/09 M1prime peptide from IgE bound by humanized antibody 47H4 Fab MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Eigenbrot, C.W., Ultsch, M.H. 2.4 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 7qbd E NA 0 B | A protein | protein NA | NA transcobalamin-2 | transcobalamin-2 TRANSPORT PROTEIN 11/19/21 TC:CD320 in complex with nanobody TC-Nb26 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens | homo sapiens Bloch, J.S., Locher, K.P. 4.18 X-RAY DIFFRACTION 0.272 0.262 False True IGHV1 NA NA None None None None None 4r7n M N 0 IMMUNE SYSTEM 08/28/14 Fab C2E3 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 3.45 X-RAY DIFFRACTION 0.280 0.236 False True IGHV4 IGKV6 Kappa None None None None None 6flc B A 0 I protein domain iii of dengue virus 2 VIRAL PROTEIN 01/25/18 2C8 Fab bound to EDIII of DenV 2 MUS MUSCULUS; DENGUE VIRUS 2 mus musculus mus musculus dengue virus 2 Flanagan, A., Renner, M., Grimes, J.M. 2.0 X-RAY DIFFRACTION 0.216 0.180 False True IGHV7 IGKV12 Kappa 1.767e-07 -9.212417624520992 SPR TBD 4k07 NA A 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 5gz0 B A 0 IMMUNE SYSTEM 09/26/16 Crystal structure of FM329, a recombinant Fab adopted from cetuximab HOMO SAPIENS/MUS MUSCULUS XENOGRAFT homo sapiens/mus musculus xenograft homo sapiens/mus musculus xenograft Sim, D.W., Kim, J.H., Kim, Y.P., Won, H.S. 1.7 X-RAY DIFFRACTION 0.227 0.188 False True IGHV2 IGKV5 Kappa None None None None None 7q0h A B 0 E protein NA spike protein s1 VIRAL PROTEIN 10/14/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-50 and Beta-54 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.65 X-RAY DIFFRACTION 0.303 0.255 False True IGHV1 IGKV3 Kappa None None None None None 1kc5 H L 0 P peptide ps1 peptide IMMUNE SYSTEM 11/07/01 CRYSTAL STRUCTURE OF ANTIBODY PC287 IN COMPLEX WITH PS1 PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Nair, D.T., Singh, K., Siddiqui, Z., Nayak, B.P., Rao, K.V., Salunke, D.M. 2.5 X-RAY DIFFRACTION 0.270 0.195 False False IGHV3 IGKV6 Kappa None None None None None 7cyp I H 0 C protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN 09/04/20 Complex of SARS-CoV-2 spike trimer with its neutralizing antibody HB27 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 6adb E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148N mutant CLC-ec1 in 20mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 2.692 X-RAY DIFFRACTION 0.278 0.237 False False IGHV4 IGKV4 Kappa None None None None None 2w65 C D 0 F peptide collagen derived peptide pcii-cit1 IMMUNE SYSTEM 12/17/08 Anti citrullinated Collagen type 2 antibody acc4 in complex with a citrullinated peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Uysal, H., Bockermann, R., Nandakumar, K.S., Sehnert, B., Bajtner, E., Engstrom, A., Serre, G., Burkhardt, H., Thunnissen, M.M.G.M., Holmdahl, R. 2.21 X-RAY DIFFRACTION 0.285 0.234 False False IGHV9 IGKV1 Kappa None None None None None 6qx4 H NA 0 B protein s-layer protein sap STRUCTURAL PROTEIN 03/07/19 Structure of the Bacillus anthracis Sap S-layer assembly domain BACILLUS ANTHRACIS; LAMA GLAMA lama glama bacillus anthracis Remaut, H., Fioravanti, A. 3.27 X-RAY DIFFRACTION 0.218 0.173 False True IGHV3 None None None None None 4xgz J K 0 j peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 4wht I J 0 i peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 7si0 C D 0 A protein NA ige fc IMMUNE SYSTEM 10/12/21 IgE-Fc in complex with 813 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.261 0.210 False True IGHV3 IGKV1 Kappa None None None None None 6k2i A NA 6 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 3mlz H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with a VI191 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.99 X-RAY DIFFRACTION 0.330 0.191 False False IGHV4 IGLV1 Lambda None None None None None 6cjk D C 0 IMMUNE SYSTEM 02/26/18 Anti HIV Fab 10A ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Hangartner, L., Ward, A.B., Wilson, I.A., Oyen, D. 1.795 X-RAY DIFFRACTION 0.206 0.163 False True IGHV1 IGKV1 Kappa None None None None None 6oq5 E NA 0 A protein toxin b TOXIN 04/25/19 Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs CLOSTRIDIOIDES DIFFICILE; CAMELIDAE camelidae clostridioides difficile Chen, P., Lam, K., Jin, R. 3.87 X-RAY DIFFRACTION 0.315 0.263 False True unknown unknown unknown None None None None None 2p49 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.4A resolution: native mono_1 crystal form CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Margalef, K., Koide, A., Kossiakoff, A.A., Koide, S. 1.38 X-RAY DIFFRACTION 0.185 0.156 False True IGHV1 2.30e-08 -10.59 Other 30 17888451 4laj M NA 0 F | G protein | peptide NA | NA hiv-1 yu2 gp120 envelope glycoprotein | cd4-mimetic miniprotein m48u1 VIRAL PROTEIN/INHIBITOR 06/20/13 Crystal structure of HIV-1 YU2 envelope gp120 glycoprotein in complex with CD4-mimetic miniprotein, M48U1, and llama single-domain, broadly neutralizing, co-receptor binding site antibody, JM4 HUMAN IMMUNODEFICIENCY VIRUS 1; LLAMA GLAMA; SYNTHETIC CONSTRUCT lama glama human immunodeficiency virus 1 | Acharya, P., Luongo, T.S., Kwong, P.D. 2.14 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 None None None None None 7f5g B NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/22/21 The crystal structure of RBD-Nanobody complex, DL4 (SA4) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Li, T., Lai, Y., Zhou, Y., Tan, J., Li, D. 1.75 X-RAY DIFFRACTION 0.217 0.188 False True IGHV1 NA NA None None None None None 7s2r B NA 0 A protein NA cytokine receptor common subunit gamma PROTEIN BINDING 09/03/21 nanobody bound to IL-2Rg HOMO SAPIENS; CAMELUS BACTRIANUS camelus bactrianus homo sapiens Glassman, C.R., Jude, K.M., Yen, M., Garcia, K.C. 2.49 X-RAY DIFFRACTION 0.271 0.246 False True IGHV1 NA NA None None None None None 7r6x A B 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/23/21 SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2E12 Fab, S309 Fab, and S304 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 2.95 X-RAY DIFFRACTION 0.262 0.232 False True IGHV1 IGKV3 Kappa None None None None None 7mjk D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4am0 E F 0 Q protein envelope protein, VIRAL PROTEIN 03/06/12 Structure of Dengue virus strain 4 DIII in complex with Fab 2H12 DENGUE VIRUS; HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus dengue virus Midgley, C.M., Flanagan, A., Mongkolsapaya, J., Grimes, J.M., Screaton, G.R. 3.02 X-RAY DIFFRACTION 0.2522 0.1960 False False IGHV1 IGKV6 Kappa 4.2e-10 -12.792176733448072 ELISA TBD 6vjn H L 0 G | F peptide | peptide NA | NA v2b peptide | v2b peptide IMMUNE SYSTEM 01/16/20 Structure of NHP D11A.B5Fab in complex with 16055 V2b peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Singh, S., Liban, T.J., Pancera, M. 2.0 X-RAY DIFFRACTION 0.236 0.180 False True IGHV4 IGLV6 Lambda None None None None None 7vae H L 0 A protein NA solute carrier family 10 (sodium/bile acid cotransporterfamily), member 1 TRANSPORT PROTEIN 08/29/21 Cryo-EM structure of bovine NTCP complexed with YN69202Fab BOS TAURUS; MUS MUSCULUS mus musculus mus musculus bos taurus Asami, J., Shimizu, T., Ohto, U. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7b14 D NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 11/23/20 Nanobody E bound to Spike-RBD in a localized reconstruction. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS BACTRIANUS camelus bactrianus severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 3.79 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7mxd X Y 0 F protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/19/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Zhou, T., Gao, F. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 3or7 A B 0 C protein voltage-gated potassium channel IMMUNE SYSTEM/TRANSPORT PROTEIN 09/06/10 On the structural basis of modal gating behavior in K+channels - E71I MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Chakrapani, S., Cordero-Morales, J.F., Jogini, V., Pan, A.C., Cortes, D.M., Roux, B., Perozo, E. 2.3 X-RAY DIFFRACTION 0.271 0.264 False False IGHV1 IGKV5 Kappa None None None None None 4nko B A 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.496 X-RAY DIFFRACTION 0.344 0.308 False True IGHV1 IGKV1 Kappa None None None None None 3okn B A 0 A carbohydrate KDO polysaccharide IMMUNE SYSTEM 08/25/10 Crystal structure of S25-39 in complex with Kdo(2.4)Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Blackler, R.J., Evans, S.V. 2.15 X-RAY DIFFRACTION 0.269 0.214 False False IGHV7 IGKV8 Kappa None None None None None 6ccb H L 0 G protein glycoprotein 120 VIRAL PROTEIN 02/06/18 Crystal structure of 253-11 SOSIP trimer in complex with 10-1074 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Moyo, T., Ereno-Orbea, J., Dorfman, J., Julien, J.P. 6.5 X-RAY DIFFRACTION 0.366 0.298 False True IGHV4 unknown unknown None None None None None 5j75 A a 0 b Hapten 6GQ N,4-dimethyl-N-{2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl]ethyl}benzene-1-sulfonamide IMMUNE SYSTEM 04/05/16 Fluorogen Activating Progein AM2.2 in complex with ML342 HOMO SAPIENS homo sapiens Stanfield, R.L., Wilson, I.A., Wu, Y. 2.0 X-RAY DIFFRACTION 0.263 0.221 True True unknown unknown unknown None None None None None 4p48 A a 0 NA NA NA NA IMMUNE SYSTEM 03/12/14 The structure of a chicken anti-cardiac Troponin I scFv GALLUS GALLUS gallus gallus Conroy, P.J., Law, R.H.P., Gillgunn, S., Hearty, S., Caradoc-Davies, T.T., Llyod, G., O'Kennedy, R.J., Whisstock, J.C. 1.35 X-RAY DIFFRACTION 0.176 0.156 True True unknown unknown unknown None None None None None 3r1g H L 0 B protein beta-secretase 1 PROTEIN BINDING 03/10/11 Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, W., Rouge, L., Wu, P., Chiu, C., Chen, Y., Wu, Y., Watts, R.J. 2.8 X-RAY DIFFRACTION 0.268 0.222 False False IGHV3 IGKV1 Kappa 1.30e-09 -12.12 SPR 25 21613622 6njm P O 0 D protein glutamate receptor 2 MEMBRANE PROTEIN/Immune System 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.5 ELECTRON MICROSCOPY False True IGHV2 IGKV10 Kappa None None None None None 4jzo C F 0 K peptide envelope glycoprotein e2 immune system/viral protein 04/03/13 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-27 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus (isolate h) Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.236 0.196 False True IGHV1 IGLV3 Lambda None None None None None 7rq6 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/05/21 Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing NTD-directed CV3-13 Fab isolated from convalescent individual SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, Y., Pozharskiy, E., Tolbert, W.D., Pazgier, M. 4.18 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV1 Kappa None None None None None 5h32 K L 0 B protein structural protein e VIRUS/IMMUNE SYSTEM 10/20/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lok, S.-M. 12 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 3upc H NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 7nks H L 0 A protein NA envelope polyprotein VIRAL PROTEIN 02/18/21 Structure of the Hantaan virus Gn glycoprotein ectodomain in complex with Fab HTN-Gn1 HANTAAN ORTHOHANTAVIRUS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus hantaan orthohantavirus Rissanen, I., Bowden, T.A., Huiskonen, J.T., Stass, R. 3.5 X-RAY DIFFRACTION 0.274 0.224 False True IGHV1 IGKV1 Kappa None None None None None 7nab H L 0 C peptide NA spike protein s2 VIRAL PROTEIN/IMMUNE SYSTEM 06/21/21 Crystal structure of human neutralizing mAb CV3-25 binding to SARS-CoV-2 S MPER peptide 1140-1165 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, Y., Tolbert, W.D., Pazgier, M. 2.15 X-RAY DIFFRACTION 0.239 0.185 False True IGHV5 IGKV1 Kappa None None None None None 3u0t D C 0 E peptide amyloid beta a4 protein IMMUNE SYSTEM 09/29/11 Fab-antibody complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens LaPorte, S.L., Pons, J.P. 2.5 X-RAY DIFFRACTION 0.268 0.219 False True IGHV1 IGKV2D Kappa 3e-10 -12.991531042419238 Unknown TBD 7shz I J 0 G protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with HAE HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.236 0.186 False True IGHV3 IGKV1 Kappa None None None None None 5k8a F E 0 IMMUNE SYSTEM 05/27/16 NIST FAB MUS MUSCULUS mus musculus mus musculus Gallagher, D.T., Galvin, C.V., Karageorgos, I., Marino, J.P. 1.999 X-RAY DIFFRACTION 0.189 0.164 False True IGHV2 IGKV1 Kappa None None None None None 5vm4 E NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 5d9q N M 0 J protein envelope glycoprotein gp120 IMMUNE SYSTEM 08/18/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Ward, A.B., Wilson, I.A. 4.4 X-RAY DIFFRACTION 0.320 0.290 False True IGHV4 IGLV3 Lambda None None None None None 3m8o H L 0 IMMUNE SYSTEM 03/18/10 Human IgA1 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Buschiazzo, A., Trajtenberg, F., Correa, A., Oppezzo, P., Pritsch, O., Dighiero, G. 1.55 X-RAY DIFFRACTION 0.182 0.153 False False IGHV3 IGKV2 Kappa None None None None None 5epm E F 0 D peptide beta-theraphotoxin-cm1a TOXIN/IMMUNE SYSTEM 11/11/15 Ceratotoxin variant in complex with specific antibody Fab fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus ceratogyrus marshalli Strop, P., Shcherbatko, A., Rossi, A. 1.75 X-RAY DIFFRACTION 0.219 0.190 False True IGHV1 IGKV1 Kappa None None None None None 7kez H L 0 V protein NA isoform l-vegf206 of vascular endothelial growth factor a IMMUNE SYSTEM 10/13/20 Crystal structure of bH1 Fab variant (CDR H3 loop design 16_0325) in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shi, R., Manenda, M.S., Picard, M.-E. 2.31 X-RAY DIFFRACTION 0.235 0.178 False True IGHV3 IGKV1 Kappa None None None None None 3u4b H L 0 IMMUNE SYSTEM 10/07/11 CH04H/CH02L Fab P4 HOMO SAPIENS homo sapiens homo sapiens Pancera, M., Louder, R., Mclellan, J.S., KWong, P.D. 2.893 X-RAY DIFFRACTION 0.268 0.221 False True IGHV3 IGKV3 Kappa None None None None None 3lrh NA E 0 F peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 6qb3 X x 0 A protein induced myeloid leukemia cell differentiation protein mcl-1 APOPTOSIS 12/20/18 Apo Mcl1 in a complex with a scFv HOMO SAPIENS homo sapiens homo sapiens Kazmirski, S., Hargreaves, D. 1.9 X-RAY DIFFRACTION 0.205 0.172 True True unknown unknown unknown None None None None None 1rzi L K 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 7jo8 NA B 0 NA NA NA NA IMMUNE SYSTEM 08/06/20 Crystal structure of a Chimeric Antigen Receptor (CAR) scFv domain rearrangement forming a VL-VL dimer SYNTHETIC CONSTRUCT synthetic construct Cheung, J., Hendrickson, W.A., Kochenderfer, J.N., Youkharibache, P. 1.399 X-RAY DIFFRACTION 0.171 0.155 True True NA IGKV3 Kappa None None None None None 6apd N O 0 A protein fusion glycoprotein f0,envelope glycoprotein IMMUNE SYSTEM 08/17/17 Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 RESPIRATORY SYNCYTIAL VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus, humanimmunodeficiency virus 1 Wrapp, D., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.256 0.204 False True IGHV3 IGLV1 Lambda None None None None None 7vdl S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/07/21 Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yu, L., Fang, Y. 3.22 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5k59 H L 0 A protein uncharacterized leukocidin-like protein 1 IMMUNE SYSTEM 05/23/16 Crystal structure of LukGH from Staphylococcus aureus in complex with a neutralising antibody STAPHYLOCOCCUS AUREUS (STRAIN USA300); HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus (strain usa300) WELIN, M., LOGAN, D.T., BADARAU, A., MIRKINA, I., ZAUNER, G., DOLEZILKOVA, I., NAGY, E. 2.84 X-RAY DIFFRACTION 0.237 0.197 False True IGHV4 IGKV1 Kappa 2.5e-12 -15.82804176815236 SPR TBD 7kf0 A B 0 C protein NA isoform l-vegf206 of vascular endothelial growth factor a IMMUNE SYSTEM 10/13/20 Crystal structure of bH1 Fab variant (CDR H3 loop design 13_0346) in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shi, R., Picard, M.-E. 2.32 X-RAY DIFFRACTION 0.246 0.192 False True IGHV3 IGKV1 Kappa None None None None None 7mf7 A B 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.231 0.203 False True IGHV3 IGLV3 Lambda None None None None None 5e2w H L 0 P peptide tau-phosphopeptide IMMUNE SYSTEM 10/01/15 Anti-TAU AT8 FAB with triply phosphorylated TAU peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Malia, T., Teplyakov, A. 1.5 X-RAY DIFFRACTION 0.220 0.216 False True IGHV3 IGKV2 Kappa 3.1e-08 -10.243615428706017 Unknown TBD 5wdu O P 0 F protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True unknown unknown unknown None None None None None 6xyf A NA 0 NA NA NA NA IMMUNE SYSTEM 01/30/20 Nanobody 22 LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.11097 X-RAY DIFFRACTION 0.153 0.125 False True IGHV1 NA NA None None None None None 2otw D C 0 F peptide poly-gln peptide antigen IMMUNE SYSTEM 02/09/07 Crystal structure of Fv polyglutamine complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Li, P. 2.35 X-RAY DIFFRACTION 0.258 0.226 False True IGHV5 IGLV3 Lambda None None None None None 7m30 F G 0 C | E protein | protein NA | NA envelope protein ul128 | ul131a VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25 HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus | human cytomegalovirus Wrapp, D., McLellan, J.S. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 3cxh J K 0 E protein cytochrome b-c1 complex subunit rieske,mitochondrial OXIDOREDUCTASE 04/24/08 Structure of yeast complex III with isoform-2 cytochrome c bound and definition of a minimal core interface for electron transfer. MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Solmaz, S.R.N., Hunte, C. 2.5 X-RAY DIFFRACTION 0.256 0.225 False True IGHV3 IGKV10 Kappa None None None None None 6sxi H L 0 NA NA NA NA IMMUNE SYSTEM 09/26/19 Antibody-anti-idiotype complex: AP33 Fab (hepatitis C virus E2 antibody) - B2.1A scFv (anti-idiotype) MUS MUSCULUS mus musculus mus musculus Taylor, G.L., Potter, J.A., Fadda, V., Patel, A.H., Owsianka, A.M., Cowtan, V.M. 1.85 X-RAY DIFFRACTION 0.203 0.156 False False IGHV3 IGKV3 Kappa None None None None None 5e2v H L 0 P peptide tau phosphopeptide IMMUNE SYSTEM 10/01/15 Anti-TAU AT8 FAB with doubly phosphorylated TAU peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Malia, T., Teplyakov, A. 1.64 X-RAY DIFFRACTION 0.208 0.165 False True IGHV3 IGKV2 Kappa 8.310000000000001e-07 -8.295148364558688 Unknown TBD 5lmj D NA 0 IMMUNE SYSTEM 08/01/16 Llama nanobody PorM_19 LAMA GLAMA lama glama Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.210 0.188 False True IGHV1 None None None None None 5uz7 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 02/24/17 Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Liang, Y.L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D.M., Furness, S.G.B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister, W., Miller, L.J., Christopoulos, A., Kobilka, B.K., Wootten, D., Skiniotis, G., Sexton, P.M. 4.1 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6x1t E F 0 Q peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 2.34 X-RAY DIFFRACTION 0.269 0.244 False True IGHV1 IGKV1 Kappa None None None None None 7ldd L l 0 A protein NA glutamate receptor 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6ol6 H L 0 IMMUNE SYSTEM 04/15/19 Structure of iglb12 scFv in complex with anti-idiotype ib2 Fab MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M., Gewe, M. 2.6 X-RAY DIFFRACTION 0.231 0.171 False True IGHV1 IGKV3 Kappa None None None None None 4unt NA C 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 2ht2 C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/25/06 Structure of the Escherichia coli ClC chloride channel Y445H mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.32 X-RAY DIFFRACTION 0.305 0.270 False False IGHV4 IGKV4 Kappa None None None None None 4jo1 I M 0 Q peptide gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/16/13 Crystal structure of rabbit mAb R56 Fab in complex with V3 crown of HIV-1 JR-FL gp120 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R.M., Kong, X.P. 2.033 X-RAY DIFFRACTION 0.223 0.181 False True IGHV1 IGKV1 Kappa None None None None None 7r9d H L 0 NA NA NA NA PROTEIN BINDING 06/29/21 Crystal structure of Nb_0 in complex with Fab_8D3 MUS MUSCULUS; VICUGNA PACOS mus musculus mus musculus Wu, X.D., Rapoport, T.A. 1.83 X-RAY DIFFRACTION 0.211 0.180 False True IGHV5 IGKV8 Kappa None None None None None 6wx2 H L 0 F peptide NA fusion peptide IMMUNE SYSTEM/VIRAL PROTEIN 05/09/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with F60P mutation on light chain in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.39 X-RAY DIFFRACTION 0.250 0.200 False True IGHV1 IGKV1 Kappa None None None None None 6tyb H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 08/08/19 Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields SIMIAN IMMUNODEFICIENCY VIRUS; MACACA MULATTA macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Kwong, P.D. 2.301 X-RAY DIFFRACTION 0.210 0.178 False True IGHV5 IGKV1 Kappa None None None None None 7jv6 H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (closed conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV7 Lambda None None None None None 7mjk F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6cbp A a 0 P peptide man9-v3 glycopeptide IMMUNE SYSTEM 02/03/18 Crystal structure of the single chain variable fragment of the DH270.6 bnAb in complex with the Man9-V3 glycopeptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens human immunodeficiency virus 1 Fera, D., Harrison, S.C. 2.17 X-RAY DIFFRACTION 0.278 0.221 True True unknown unknown unknown 7e-06 -7.032544530399885 Unknown TBD 4xcy H L 0 H Hapten 44G (2S)-3-{[(R)-{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidylglycerol (06:0 PG) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 3.96 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 IGKV3 Kappa None None None None None 3mme C D 0 D carbohydrate NAG polysaccharide IMMUNE SYSTEM 04/19/10 Structure and functional dissection of PG16, an antibody with broad and potent neutralization of HIV-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pancera, M., McLellan, J., Zhou, T., Zhu, J., Kwong, P. 3.97 X-RAY DIFFRACTION 0.317 0.256 False True IGHV3 IGLV2 Lambda None None None None None 7mxd S U 0 G protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 05/19/21 Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Gao, F. 3.4 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7jmx H L 0 NA NA NA NA IMMUNE SYSTEM 08/03/20 Crystal structure of a SARS-CoV-2 cross-neutralizing antibody COVA1-16 Fab HOMO SAPIENS homo sapiens homo sapiens Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.53 X-RAY DIFFRACTION 0.244 0.212 False True IGHV1 IGKV1 Kappa None None None None None 7so9 J I 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.2 delta variant + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6m1i C NA 0 F | E protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PROTEIN BINDING 02/26/20 CryoEM structure of human PAC1 receptor in complex with PACAP38 HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Song, X., Wang, J., Zhang, D., Wang, H.W., Ma, Y. 3.5 ELECTRON MICROSCOPY False True IGHV3 None None None None None 5vta K J 0 A protein dipeptidyl peptidase 4 HYDROLASE 05/16/17 Co-Crystal Structure of DPPIV with a Chemibody Inhibitor RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Johnstone, S., Cheng, A. 2.8 X-RAY DIFFRACTION 0.300 0.250 False True IGHV1 IGKV4 Kappa None None None None None 4nzr H L 0 M protein protein m td IMMUNE SYSTEM/PROTEIN BINDING 12/12/13 Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-HIV antibody PGT135 Fab HOMO SAPIENS; MYCOPLASMA GENITALIUM homo sapiens homo sapiens mycoplasma genitalium Zhu, X., Wilson, I.A. 1.65 X-RAY DIFFRACTION 0.186 0.154 False True IGHV4 IGKV3 Kappa None None None None None 5t0y H L 0 IMMUNE SYSTEM 08/17/16 2A10 Antibody FAB fragment MUS MUSCULUS mus musculus mus musculus Jackson, C.J., Fisher, C. 3.011 X-RAY DIFFRACTION 0.247 0.225 False True IGHV9 IGKV10 Kappa None None None None None 3whe 1 2 0 H protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 4ybq F E 0 A protein solute carrier family 2, facilitated glucose transportermember 5 TRANSPORT PROTEIN/IMMUNE SYSTEM 02/19/15 Rat GLUT5 with Fv in the outward-open form MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Nomura, N., Shimamura, T., Iwata, S. 3.27 X-RAY DIFFRACTION 0.288 0.242 False True IGHV5 IGKV1 Kappa None None None None None 5eor H L 0 A peptide protein a27 VIRAL PROTEIN/IMMUNE SYSTEM 11/10/15 Structure of the murine antibody Fab 8E3 bound to the vaccinia virus A27 peptide 101-110 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus vaccinia virus Matho, M.H., Zajonc, D.M. 2.27 X-RAY DIFFRACTION 0.224 0.203 False False IGHV2 IGLV3 Lambda None None None None None 2ltq F E 3 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 6w0g A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Closed-gate KcsA soaked in 1mM KCl/5mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 2.6 X-RAY DIFFRACTION 0.245 0.196 False True IGHV1 IGKV5 Kappa None None None None None 5uk4 g NA 0 G protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 4lsv H L 0 G protein envelope glycoprotein gp120 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody 3BNC117 in complex with HIV-1 clade C C1086 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 3.0 X-RAY DIFFRACTION 0.299 0.260 False True unknown IGKV1 Kappa None None None None None 1h8s B b 0 ANTI-AMPICILLIN ANTIBODIES 02/15/01 Three-dimensional structure of anti-ampicillin single chain Fv fragment complexed with the hapten. MUS MUSCULUS mus musculus Burmester, J., Spinelli, S., Pugliese, L., Krebber, A., Honegger, A., Jung, S., Schimmele, B., Cambillau, C., Plucktun, A. 2.4 X-RAY DIFFRACTION 0.273 0.204 True True unknown unknown unknown 1.5399999999999999e-06 -7.92964050141843 Unknown TBD 3qum D C 0 Q protein prostate-specific antigen IMMUNE SYSTEM 02/24/11 Crystal structure of human prostate specific antigen (PSA) in Fab sandwich with a high affinity and a PCa selective antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Stura, E.A., Muller, B.H., Michel, S., Ducancel, F. 3.2 X-RAY DIFFRACTION 0.294 0.198 False False IGHV1 IGKV3 Kappa None None None None None 6axl D C 0 G peptide peptide ace-asn-pro-asn-ala-asn-pro-asn-ala-asn-pro-asn-ala-nh2 IMMUNE SYSTEM 09/07/17 Crystal structure of Fab317 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Oyen, D., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.217 0.175 False True IGHV3 IGKV1 Kappa 7.8e-08 -9.696917926366758 Unknown TBD 7doh H L 0 I peptide NA gly-thr-gly-ala-thr-pro-ala-asp-asp IMMUNE SYSTEM 12/14/20 Crystal Structure of GD-26 Fab in Complex with TD Peptide from Haloarcula Marismortui Bacteriorhodopsin I MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus haloarcula marismortui Lee, C.C., Pao, P.J., Wang, A.H.J. 1.45 X-RAY DIFFRACTION 0.178 0.130 False True IGHV1 IGKV1 Kappa None None None None None 6cw3 A B 0 H | G protein | protein NA | NA histone acetyltransferase gcn5 | transcriptional adapter 2 GENE REGULATION 03/29/18 Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 2 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE S288C homo sapiens homo sapiens saccharomyces cerevisiae s288c | saccharomyces cerevisiae s288c Sun, J., Paduch, M., Kim, S.A., Kramer, R.M., Barrios, A.F., Lu, V., Luke, J., Usatyuk, S., Kossiakoff, A.A., Tan, S. 1.98 X-RAY DIFFRACTION 0.227 0.203 False True IGHV3 IGKV1 Kappa None None None None None 7kdd H I 0 C protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 10/08/20 HCMV postfusion gB in complex with SM5-1 Fab HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS (STRAIN TOWNE) homo sapiens homo sapiens human cytomegalovirus (strain towne) Liu, Y., Heim, P.K., Che, Y., Chi, X., Qiu, X., Han, S., Dormitzer, P.R., Yang, X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7nx6 A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.25 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGKV3 Kappa None None None None None 7tfn P Q 0 C protein NA envelope glycoprotein bg505 sosip.664 - gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/06/22 Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV4 Lambda None None None None None 1iqd B A 0 C protein human factor viii IMMUNE SYSTEM/BLOOD CLOTTING 07/21/01 Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Spiegel Jr., P.C., Jacquemin, M., Saint-Remy, J.M., Stoddard, B.L., Pratt, K.P. 2.0 X-RAY DIFFRACTION 0.253 0.203 False False IGHV1 IGKV3 Kappa 1.40e-11 -14.8 SPR 9657749 6pdx O P 0 C protein hemagglutinin IMMUNE SYSTEM 06/19/19 Crystal structure of C585 Fab in complex with influenza virus hemagglutinin from A/Switzerland/9715293/2013 (H3N2) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Qiu, Y., Zhou, Y. 3.993 X-RAY DIFFRACTION 0.242 0.212 False True IGHV4 IGLV1 Lambda None None None None None 7lq7 F G 0 E protein NA spike protein s1 IMMUNE SYSTEM 02/13/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 IGLV2 Lambda None None None None None 7beo E F 0 X protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253H55L and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 3.19 X-RAY DIFFRACTION 0.274 0.234 False True IGHV3 IGKV1 Kappa None None None None None 6k6b NA A 0 B protein protein a STRUCTURAL PROTEIN 06/02/19 Application of anti-helix antibodies in protein structure determination (8496-3LRH) HOMO SAPIENS; STAPHYLOCOCCUS AUREUS homo sapiens staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 2.06 X-RAY DIFFRACTION 0.248 0.202 False True IGLV1 Lambda None None None None None 6pk8 B b 0 NA NA NA NA IMMUNE SYSTEM 06/28/19 Antibody scFv-M204 dimeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 2.91 X-RAY DIFFRACTION 0.238 0.186 True True unknown unknown unknown None None None None None 7eq1 S s 0 A | Y | B protein | protein | protein NA | NA | NA gs protein alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 04/28/21 GPR114-Gs-scFv16 complex BOS TAURUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT; RATTUS NORVEGICUS synthetic construct bos taurus | bos taurus | rattus norvegicus Ping, Y. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7czu J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B6_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2kh2 B b 29 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5o14 C D 0 B protein factor h binding protein variant 1.1 IMMUNE SYSTEM 05/18/17 Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein NEISSERIA MENINGITIDIS SEROGROUP B (STRAIN MC58); HOMO SAPIENS homo sapiens homo sapiens neisseria meningitidis serogroup b (strainmc58) Lopez-Sagaseta, J. 2.195 X-RAY DIFFRACTION 0.250 0.192 False True IGHV5 IGKV1 Kappa None None None None None 1fdl H L 0 Y protein hen egg white lysozyme COMPLEX (ANTIBODY-ANTIGEN) 08/27/90 CRYSTALLOGRAPHIC REFINEMENT OF THE THREE-DIMENSIONAL STRUCTURE OF THE FAB D1.3-LYSOZYME COMPLEX AT 2.5-ANGSTROMS RESOLUTION MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Fischmann, T.O., Poljak, R.J. 2.5 X-RAY DIFFRACTION unknown 0.184 False True IGHV2 IGKV12 Kappa None None None None None 6bli J K 0 L peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/10/17 RSV G peptide bound to Fab CB002.5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human respiratory syncytial virus a (strainrsb6256) Jones, H.G., McLellan, J.S., Langedijk, J.P. 2.12 X-RAY DIFFRACTION 0.218 0.169 False True IGHV4 IGKV1 Kappa 5.200000000000001e-10 -12.665637564550789 Unknown TBD 4gsd H L 0 IMMUNE SYSTEM 08/27/12 H5.3 Fab Structure HOMO SAPIENS homo sapiens homo sapiens Spiller, B.W, Winarski, K.L. 2.251 X-RAY DIFFRACTION 0.203 0.172 False True IGHV4 IGLV3 Lambda None None None None None 6x5m H L 0 R nucleic-acid NA ggpan rna (39-mer) Immune System/RNA 05/26/20 Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Swain, M., Li, M., Wlodawer, A., Le Grice, S.F.J. 2.5 X-RAY DIFFRACTION 0.279 0.207 False True IGHV3 IGKV1 Kappa None None None None None 7zwm I J 0 F protein NA gametocyte surface protein p45/48 CELL ADHESION 05/19/22 Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 3.69 X-RAY DIFFRACTION 0.280 0.255 False True IGHV5 IGKV8 Kappa None None None None None 7ul7 E D 0 c protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 04/04/22 Lineage I (Pinneo) Lassa virus glycoprotein bound to 18.5C-M30 Fab LASSA MAMMARENAVIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa mammarenavirus Buck, T.K., Enriquez, A.S., Hastie, K.M. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5f7n C NA 0 A protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group A Lewis b pentasaccharide HELICOBACTER PYLORI helicobacter pylori helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.28 X-RAY DIFFRACTION 0.197 0.171 False True IGHV1 None None None None None 6vca P O 0 D protein NA 5'-nucleotidase, ecto (cd73), isoform cra_a IMMUNE SYSTEM 12/20/19 TB38 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhou, Y.F., Lord, D.M. 3.73 X-RAY DIFFRACTION 0.264 0.224 False True IGHV3 IGLV8 Lambda None None None None None 1ngq H L 0 IMMUNOGLOBULIN 06/23/95 N1G9 (IGG1-LAMBDA) FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus Mizutani, R., Satow, Y. 2.4 X-RAY DIFFRACTION 0.254 0.194 False False IGHV1 IGLV1 Lambda None None None None None 6h0e E F 0 J peptide microtubule-associated protein tau IMMUNE SYSTEM 07/09/18 FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens mus musculus Juraszek, J., Steinbacher, S. 1.95 X-RAY DIFFRACTION 0.285 0.222 False True IGHV1 IGKV2 Kappa 2.4000000000000003e-07 -9.031007686639388 Unknown TBD 7det B b 0 A protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 11/05/20 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y., Zhang, G., Li, X., Rao, Z., Guo, Y. 2.2 X-RAY DIFFRACTION 0.260 0.212 True True unknown unknown unknown None None None None None 6q1z D C 0 B protein neuraminidase VIRAL PROTEIN,HYDROLASE/IMMUNE SYSTEM 08/06/19 Crystal structure of human 1G04 Fab in complex with influenza virus neuraminidase from A/Hunan/02650/2016 (H7N9) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 3.446 X-RAY DIFFRACTION 0.247 0.197 False True IGHV3 IGKV1 Kappa None None None None None 7bpk H L 0 B protein NA envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 03/23/20 Zika virus envelope protein mutant bound to mAb ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Dai, L., Qi, J., Gao, G.F. 3.1 X-RAY DIFFRACTION 0.268 0.232 False True IGHV3 IGLV1 Lambda None None None None None 4qyo A B 0 Q peptide merozoite surface antigen 2 IMMUNE SYSTEM 07/24/14 Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with MSP2 14-22 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum k1 Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S. 1.208 X-RAY DIFFRACTION 0.170 0.151 False True IGHV14 IGKV3 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 5d96 J I 0 D protein sulfhydryl oxidase 1 IMMUNE SYSTEM 08/18/15 Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from an Antibody Targeting Mouse and Human QSOX1 OTHER SEQUENCES; MUS MUSCULUS other sequences other sequences mus musculus Fass, D., Grossman, I. 2.3 X-RAY DIFFRACTION 0.228 0.167 False True IGHV2 IGKV6 Kappa None None None None None 2v7h B A 0 IMMUNE SYSTEM 07/30/07 Crystal structure of an immunogen specific anti-mannopyranoside monoclonal antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Krishnan, L., Sahni, G., Kaur, K.J., Salunke, D.M. 2.8 X-RAY DIFFRACTION 0.2676 0.2424 False False IGHV1 IGKV10 Kappa None None None None None 4org E F 0 IMMUNE SYSTEM 02/11/14 Crystal structure of human Fab CAP256-VRC26.04, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 3.121 X-RAY DIFFRACTION 0.289 0.275 False True IGHV3 IGLV1 Lambda None None None None None 7xod U V 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/01/22 SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xu, Y., Wu, C., Liu, H., Yin, W., Xu, H.E. 3.27 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7p5v K NA 0 E protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5uxq H L 0 IMMUNE SYSTEM 02/23/17 Structure of anti-HIV trimer apex antibody PGT143 HOMO SAPIENS homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.415 X-RAY DIFFRACTION 0.267 0.229 False True IGHV1 IGKV2 Kappa None None None None None 5uqy L K 0 I | N protein | protein NA | NA envelope glycoprotein gp1 | envelope glycoprotein gp2 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/17 Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 LAKE VICTORIA MARBURGVIRUS (STRAIN RAVN-87); HOMO SAPIENS homo sapiens homo sapiens lake victoria marburgvirus (strain ravn-87) | lake victoria marburgvirus (strain ravn-87) Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O. 3.6 X-RAY DIFFRACTION 0.262 0.221 False False IGHV4 IGKV1 Kappa None None None None None 6elu E F 0 D protein serum resistance associated; vsg protein ANTITOXIN 09/29/17 Structure of Serum Resistance Associated protein from T. b. rhodesiense TRYPANOSOMA BRUCEI RHODESIENSE; MUS MUSCULUS mus musculus mus musculus trypanosoma brucei rhodesiense Zoll, S., Higgins, M.K. 2.3 X-RAY DIFFRACTION 0.220 0.191 False True IGHV7 IGKV3 Kappa None None None None None 7mf7 H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.231 0.203 False True IGHV3 IGLV3 Lambda None None None None None 6btj H L 0 NA NA NA NA ANTIVIRAL PROTEIN 12/06/17 Crystal structure of pan-H7, anti-hemagglutinin monoclonal antibody H7.5 (Fab fragment) HOMO SAPIENS homo sapiens homo sapiens Shanshan, L., Ian, A.W. 1.999 X-RAY DIFFRACTION 0.201 0.200 False True IGHV1 IGKV1 Kappa None None None None None 7b18 G NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/24/20 SARS-CoV-spike bound to two neutralising nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4k2u H L 0 A protein erythrocyte binding antigen 175 IMMUNE SYSTEM 04/09/13 Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Tolia, N.H. 2.45 X-RAY DIFFRACTION 0.253 0.204 False False IGHV14 IGKV10 Kappa 1.53e-11 -14.754720790655165 SPR TBD 4hih D C 0 D carbohydrate RAM ALPHA-L-RHAMNOSE IMMUNE SYSTEM 10/11/12 Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound rhamnose. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S, Thomson, C.A., Schrader, J.W., Pai, E.F. 2.0 X-RAY DIFFRACTION 0.236 0.224 False True IGHV3 IGKV3 Kappa None None None None None 6rlm A B 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 6nm6 D E 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 01/10/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to N6 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.2 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.739 X-RAY DIFFRACTION 0.288 0.240 False True unknown unknown unknown None None None None None 7djy B NA 0 NA NA NA NA BIOSYNTHETIC PROTEIN 11/22/20 Clec4f Nanobody 322 LAMIUM MACULATUM lamium maculatum Wen, Y., Zheng, F. 2.7 X-RAY DIFFRACTION 0.266 0.228 False True IGHV1 NA NA None None None None None 3gk8 H L 0 IMMUNE SYSTEM 03/10/09 X-ray crystal structure of the Fab from MAb 14, mouse antibody against Canine Parvovirus MUS MUSCULUS mus musculus mus musculus Hafenstein, S., Bowman, V., Sun, T., Nelson, C., Palermo, L., Chipman, P., Battisti, A., Parrish, C. 2.0 X-RAY DIFFRACTION 0.306 0.266 False True IGHV1 IGKV6 Kappa None None None None None 6qgx B NA 0 A protein outer membrane protein assembly factor bama MEMBRANE PROTEIN 01/14/19 Crystal structure of E.coli BamA beta-barrel in complex with nanobody F7 ESCHERICHIA COLI O157:H7; LAMA GLAMA lama glama escherichia coli o157 Hartmann, J.-B., Kaur, H., Jakob, R.P., Zahn, M., Zimmermann, I., Seeger, M., Maier, T., Hiller, S. 2.2 X-RAY DIFFRACTION 0.266 0.229 False True IGHV1 None None None None None 6jri F NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 7cw2 U T 0 E | D protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263 (subregion around icosahedral 5-fold vertex) CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 4.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 6p95 H L 0 c | C protein | protein NA | NA unknown | pre-glycoprotein polyprotein gp complex viral protein/immune system 06/09/19 Structure of Lassa virus glycoprotein in complex with Fab 25.6A LASSA VIRUS; HOMO SAPIENS; LASSA VIRUS (STRAIN MOUSE/SIERRA LEONE/JOSIAH/1976) homo sapiens homo sapiens lassa virus (strain mouse/sierraleone/josiah/1976) | lassa virus Saphire, E.O., Hastie, K.M. 3.5 X-RAY DIFFRACTION 0.247 0.205 False True IGHV3 IGLV2 Lambda None None None None None 7aqg B NA 0 A protein NA plasminogen activator inhibitor 1 HYDROLASE 10/21/20 Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Strelkov, S.V., Declerck, P.J. 2.27 X-RAY DIFFRACTION 0.268 0.215 False True IGHV1 NA NA None None None None None 7m6f H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, BG1-22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 3kym F E 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 6x9u H L 0 A | B protein | protein NA | NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 | hiv-1 envelope glycoprotein bg505 sosip.664 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 06/03/20 HIV-1 Envelope Glycoprotein BG505 SOSIP.664, expressed in HEK293S cells and partially deglycosylated by endoglycosidase H, in complex with RM20A3 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 5v6m H L 0 P peptide envelope glycoprotein gp120 v3 peptide of con b sequence VIRAL PROTEIN/IMMUNE SYSTEM 03/17/17 Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A3 in complex with V3 peptide ConB ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R., Kong, X.-P. 1.9 X-RAY DIFFRACTION 0.224 0.179 False True IGHV1 IGKV1 Kappa None None None None None 7evz E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of cenerimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yuan, Y., Jia, G.W., Shao, Z.H., Su, Z.M. 3.07 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5mp6 P Q 0 IMMUNE SYSTEM 12/15/16 Structure of the Unliganded Fab from HIV-1 Neutralizing Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface, at two Angstrom resolution. HOMO SAPIENS homo sapiens homo sapiens Wibmer, C.K., Gorman, J., Kwong, P.D. 1.959 X-RAY DIFFRACTION 0.240 0.198 False True IGHV4 IGLV2 Lambda None None None None None 6dbe A NA 0 IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R330 LAMA GLAMA lama glama Brooks, C.L., Toride King, M., Huh, I. 1.65 X-RAY DIFFRACTION 0.223 0.185 False True IGHV1 None None None None None 6idl I J 0 E protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 5.0 (Class II particle) DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 25 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 2y6s H L 0 Q peptide envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/25/11 Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus zaire ebolavirus Olal, D.O., Kuehne, A., Lee, J.E., Bale, S., Dye, J.M., Saphire, E.O. 2.8 X-RAY DIFFRACTION 0.2873 0.2359 False False IGHV1 IGKV3 Kappa 1.0300000000000001e-07 -9.532195517943316 Unknown TBD 5dtf H L 0 P peptide peptide IMMUNE SYSTEM 09/18/15 context-independent anti-hypusine antibody FabHpu98.61 in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Zhai, Q., Carter, P.J. 1.9 X-RAY DIFFRACTION 0.254 0.212 False True IGHV1 IGKV1 Kappa None None None None None 3okk B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 08/25/10 Crystal structure of S25-39 in complex with Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Blackler, R.J., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.234 0.195 False False IGHV7 IGKV8 Kappa None None None None None 6fe4 G NA 0 B protein shiga-like toxin 2 subunit b TOXIN 12/29/17 Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113 ENTEROBACTERIA PHAGE 933W; VICUGNA PACOS vicugna pacos enterobacteria phage 933w Bernedo, R., Muyldermans, S., Sterckx, Y.G.J. 3.0 X-RAY DIFFRACTION 0.207 0.169 False True IGHV3 9.6e-09 -10.938139080820335 SPR TBD 1j5o H L 0 B protein reverse transcriptase TRANSFERASE/IMMUNE SYSTEM/DNA 05/24/02 CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Sarafianos, S.G., Das, K., Arnold, E. 3.5 X-RAY DIFFRACTION 0.338 0.262 False False IGHV8 IGKV10 Kappa None None None None None 7ew5 T U 0 P protein NA major capsid protein l1 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 4r4h H L 0 A protein NA hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of non-neutralizing, A32-like antibody 2.2c in complex with HIV-1 Env gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Mclellan, J., Acharya, P., Huang, C.-C., Kwong, P.D. 4.28 X-RAY DIFFRACTION 0.320 0.309 False True IGHV4 IGKV1 Kappa None None None None None 4hg4 Z z 0 I protein hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 7qez H L 0 A protein NA spike protein s1 VIRAL PROTEIN 12/03/21 Crystal structure of the SARS-CoV-2 RBD in complex with the ultrapotent antibody CV2.1169 and CR3022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fernandez, I., Rey, F.A. 2.89 X-RAY DIFFRACTION 0.281 0.239 False True IGHV1 IGKV3 Kappa None None None None None 5tdn B A 0 IMMUNE SYSTEM 09/19/16 Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces HOMO SAPIENS homo sapiens homo sapiens Yin, Y., Carter, P.J. 1.63 X-RAY DIFFRACTION 0.215 0.185 False True IGHV3 IGKV1 Kappa None None None None None 6e9q G H 0 IMMUNE SYSTEM 05/01/19 The crystal structure of bovine ultralong antibody BOV-6 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.4 X-RAY DIFFRACTION 0.311 0.254 False True IGHV1 IGLV1 Lambda None None None None None 7mxp G J 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/19/21 Cryo-EM structure of NTD-directed neutralizing antibody LP5 Fab in complex with SARS-CoV-2 S2P spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Casner, R.G., Shapiro, L. 4.46 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 1jhk H L 0 IMMUNE SYSTEM 06/28/01 Crystal structure of the anti-estradiol antibody 57-2 MUS MUSCULUS mus musculus mus musculus Lamminmaki, U., Kankare, J.A. 2.51 X-RAY DIFFRACTION 0.262 0.198 False True IGHV9 IGKV12 Kappa None None None None None 6ule C D 0 I peptide circumsporozoite protein IMMUNE SYSTEM 06/10/20 Crystal structure of 2541 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Thai, E., Scally, S.W., Murugan, R., Wardemann, H., Julien, J.P. 2.55 X-RAY DIFFRACTION 0.259 0.209 False True IGHV3 IGKV1 Kappa None None None None None 5otj H L 0 C protein polcalcin phl p 7 IMMUNE SYSTEM 08/22/17 Monomeric polcalcin (Phl p 7) in complex with two identical allergen-specific antibodies HOMO SAPIENS; PHLEUM PRATENSE homo sapiens homo sapiens phleum pratense Mitropoulou, A.N., Davies, A.M., Beavil, A.J., McDonnell, J.M., Sutton, B.J. 2.35 X-RAY DIFFRACTION 0.235 0.199 False True IGHV1 IGLV1 Lambda 1.7000000000000003e-10 -13.328052315201264 SPR TBD 4m62 H L 0 S protein t117 IMMUNE SYSTEM 08/08/13 Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Finton, K.A.K. 1.8 X-RAY DIFFRACTION 0.216 0.189 False True IGHV1 IGKV3 Kappa 2.57e-09 -11.718947964134085 SPR TBD 7d2z A NA 0 B protein NA spike protein s1 PROTEIN BINDING 09/17/20 Structure of sybody SR31 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD) SYNTHETIC CONSTRUCT; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 synthetic construct severe acute respiratory syndrome coronavirus2 Li, T., Cai, H., Yao, H., Qin, W., Li, D. 1.97 X-RAY DIFFRACTION 0.207 0.182 False True IGHV1 NA NA None None None None None 7m1h G NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/13/21 Crystal structure of LC/A-JPU-C10-JPU-D12-JPU-B8-JPU-G3-ciA-F12-ciA-D12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.78 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 NA NA None None None None None 3gje H L 0 IMMUNE SYSTEM 03/08/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS homo sapiens homo sapiens Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E., Kleber, S., Stenner-Liewen, F., Bauer, S., McMichael, A., Knuth, A., Abken, H., Hombach, A.A., Cerundolo, V., Jones, E.Y., Renner, C. 2.3 X-RAY DIFFRACTION 0.302 0.222 False True IGHV3 IGLV2 Lambda None None None None None 1cfq B A 0 POLYSPECIFICITY 03/19/99 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 MUS MUSCULUS mus musculus mus musculus Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J., Hoehne, W. 2.8 X-RAY DIFFRACTION 0.312 0.221 False False IGHV1 IGKV14 Kappa None None None None None 7cwt E D 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike protein in complex with hb27 and fc05 Fab cocktail SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cui, Z., Wang, X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 5wb2 D NA 0 MEMBRANE PROTEIN 06/27/17 US28 bound to engineered chemokine CX3CL1.35 and nanobodies HUMAN CYTOMEGALOVIRUS; LAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct Jude, K.M., Burg, J.S., Tsutsumi, N., Miles, T.F., Garcia, K.C. 3.5 X-RAY DIFFRACTION 0.296 0.252 False True IGHV1 None None None None None 35c8 H L 0 L Hapten NOX N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE CATALYTIC ANTIBODY 03/18/98 CATALYTIC ANTIBODY 5C8, FAB-INHIBITOR COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gruber, K., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.261 0.206 False False IGHV14 IGKV4 Kappa None None None None None 7fej H L 0 2 | 1 protein | protein NA | NA a/af/72 vp2 | a/af/72 vp1 VIRUS 07/20/21 Complex of FMDV A/AF/72 and bovine neutralizing scFv antibody R55 BOS TAURUS; FOOT-AND-MOUTH DISEASE VIRUS bos taurus bos taurus foot-and-mouth disease virus | foot-and-mouth disease virus Yong, H., Kun, L., Zhiyong, L. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 4krl B NA 0 A protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.849 X-RAY DIFFRACTION 0.268 0.213 False True IGHV1 4.7000000000000004e-08 -9.997047185087938 SPR TBD 2p42 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE3-mono-2 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 1.8 X-RAY DIFFRACTION 0.215 0.171 False True IGHV1 2.30e-08 -10.59 Other 30 18445622 4f15 B C 0 A protein hemagglutinin IMMUNE SYSTEM 05/06/12 Molecular basis of infectivity of 2009 pandemic H1N1 influenza A viruses INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Kim, K.H., Cho, K.J., Lee, J.H., Park, Y.H., Khan, T.G., Lee, J.Y., Kang, S.H., Alam, I. 2.81 X-RAY DIFFRACTION 0.289 0.233 False False IGHV3 IGKV7 Kappa None None None None None 5m6a NA C 0 IMMUNE SYSTEM 10/24/16 Crystal structure of cardiotoxic Bence-Jones light chain dimer H9 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 1.64 X-RAY DIFFRACTION 0.203 0.183 False False IGLV2 Lambda None None None None None 5mv4 C D 0 E peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 6xc2 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 3.112 X-RAY DIFFRACTION 0.267 0.213 False True IGHV3 IGKV1 Kappa None None None None None 3moa H L 0 P peptide gp41 mper-derived peptide IMMUNE SYSTEM 04/22/10 Crystal structure of the neutralizing HIV antibody 2F5 Fab fragment (recombinantly produced Fab) with 17 aa gp41 MPER-derived peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 2.3 X-RAY DIFFRACTION 0.219 0.184 False True IGHV2 IGKV1 Kappa None None None None None 7czt H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2G9 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV5 Lambda None None None None None 6dfg H L 0 A protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 05/14/18 BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Steichen, J.M., Schief, W.R., Ward, A.B. 4.42 ELECTRON MICROSCOPY False True unknown IGLV3 Lambda None None None None None 3ob0 H L 0 H Hapten 2M6 7-DEOXY-L-GLYCERO-ALPHA-D-MANNO-HEPTOPYRANOSYL-(1->2)-ALPHA-D-MANNOPYRANOSYL-(1->2)-ALPHA-D-MANNOPYRANOSYL-(1->3)-ALPHA-D-MANNOPYRANOSE IMMUNE SYSTEM 08/06/10 A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity HOMO SAPIENS homo sapiens homo sapiens homo sapiens Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G 2.85 X-RAY DIFFRACTION 0.280 0.232 False True IGHV3 IGKV1 Kappa None None None None None 7pr0 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 09/20/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FD-5D Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.92 X-RAY DIFFRACTION 0.251 0.214 False True IGHV3 IGKV2 Kappa None None None None None 2eh7 H L 0 IMMUNE SYSTEM 03/05/07 Crystal structure of humanized KR127 FAB MUS MUSCULUS mus musculus mus musculus Chi, S.-W., Kim, S.-J., Maeng, C.-Y., Hong, H.J., Ryu, S.-E. 2.5 X-RAY DIFFRACTION 0.252 0.207 False True IGHV1 IGKV1 Kappa None None None None None 6oe5 H L 0 A protein fusion glycoprotein f0,fibritin Viral protein/immune system 03/27/19 Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); ENTEROBACTERIA PHAGE T4; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.306 0.262 False True IGHV4 IGKV1 Kappa None None None None None 7q9i J K 0 C protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-43 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7rxp H L 0 A protein NA circumsporozoite protein IMMUNE SYSTEM 08/23/21 Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 1.761 X-RAY DIFFRACTION 0.205 0.177 False True IGHV3 IGKV2 Kappa None None None None None 6vrh B C 0 A protein sodium-dependent serotonin transporter TRANSPORT PROTEIN 02/07/20 Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Navratna, V., Yang, D. 3.3 ELECTRON MICROSCOPY False True IGHV1 IGKV6 Kappa None None None None None 5uk4 j NA 0 J protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 1ieh A NA 7 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 1bj1 K J 0 V protein vascular endothelial growth factor COMPLEX (ANTIBODY/ANTIGEN) 06/30/98 VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Muller, Y.A., Christinger, H.W., De Vos, A.M. 2.4 X-RAY DIFFRACTION 0.266 0.196 False True IGHV7 IGKV1 Kappa 3.40e-09 -11.55 SPR 25 9753694 6wty E F 0 D protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 253245 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.481 X-RAY DIFFRACTION 0.301 0.262 False True IGHV1 IGLV2 Lambda None None None None None 7q9g E F 0 B protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 COVOX-222 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5w1m H G 0 S protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 MACV GP1 CR1-07 Fab complex HOMO SAPIENS; MACHUPO VIRUS homo sapiens homo sapiens machupo virus Raymond, D.D., Clark, L.E., Abraham, J. 3.91 X-RAY DIFFRACTION 0.264 0.248 False True IGHV3 IGKV4 Kappa 1.63e-08 -10.624477030127814 SPR TBD 5c6t H L 0 A protein envelope glycoprotein b Viral Protein/Immue System 06/23/15 Crystal structure of HCMV glycoprotein B in complex with 1G2 Fab HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS homo sapiens homo sapiens human cytomegalovirus Chandramouli, S., Ciferri, C., Settembre, E.C., Carfi, A. 3.6 X-RAY DIFFRACTION 0.260 0.212 False True IGHV4 IGLV1 Lambda 1.3000000000000002e-10 -13.48699434919035 SPR TBD 6cdo A B 0 C peptide hiv-1 fusion peptide 512-519 IMMUNE SYSTEM 02/08/18 Structure of vaccine-elicited HIV-1 neutralizing antibody vFP16.02 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.099 X-RAY DIFFRACTION 0.226 0.194 False True IGHV1 IGKV1 Kappa 1.06e-09 -12.243673427577415 Unknown TBD 4aq1 B NA 0 STRUCTURAL PROTEIN 04/12/12 Structure of the SbsB S-layer protein of Geobacillus stearothermophilus PV72p2 in complex with nanobody KB6 GEOBACILLUS STEAROTHERMOPHILUS; LAMA GLAMA lama glama Baranova, E., Remaut, H. 2.42 X-RAY DIFFRACTION 0.23567 0.18301 False True IGHV1 None None None None None 7ps7 H L 0 R protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-40 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.9 X-RAY DIFFRACTION 0.284 0.233 False True IGHV4 IGLV3 Lambda None None None None None 3mug H G 0 IMMUNE SYSTEM 05/03/10 Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Pejchal, R., Walker, L.M., Burton, D.R., Wilson, I.A. 2.49 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 IGLV2 Lambda None None None None None 5wl2 A B 0 ANTIVIRAL PROTEIN 07/25/17 VH1-69 germline antibody with CDR H3 sequence of CR9114 HOMO SAPIENS homo sapiens homo sapiens Wilson, I.A., Lang, S. 2.0 X-RAY DIFFRACTION 0.236 0.200 False True IGHV1 IGLV1 Lambda None None None None None 1fve D C 0 IMMUNOGLOBULIN 10/20/92 X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Randal, M., Presta, L., Kossiakoff, A.A. 2.7 X-RAY DIFFRACTION unknown 0.171 False True IGHV3 IGKV1 Kappa None None None None None 4g6m H L 0 A protein interleukin-1 beta IMMUNE SYSTEM 07/19/12 Crystal strucure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab homo sapiens homo sapiens homo sapiens Blech, M., Hoerer, S. 1.81 X-RAY DIFFRACTION 0.226 0.202 False True IGHV4 IGKV1 Kappa 2.9e-10 -13.011617158513758 SPR TBD 5jw3 H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment in Complex with H7 HA HOMO SAPIENS; INFLUENZA A VIRUS (A/TURKEY/ITALY/214845/2002(H7N3)) homo sapiens homo sapiens influenza a virus(a/turkey/italy/214845/2002(h7n3)) | influenza a virus(a/turkey/italy/214845/2002(h7n3)) Collins, P.J., Neu, U., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 3.75 X-RAY DIFFRACTION 0.263 0.224 False True IGHV6 IGKV1 Kappa None None None None None 4zfo A B 0 F peptide tumor necrosis factor receptor superfamily member 17 IMMUNE SYSTEM 04/21/15 J22.9-xi: chimeric mouse/human antibody against human BCMA (CD269) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Marino, S.F., Daumke, O., Olal, D. 1.895 X-RAY DIFFRACTION 0.209 0.176 False True IGHV4 IGKV6 Kappa 2.1e-11 -14.567099215178107 Unknown TBD 6wgl A B 0 C protein NA interleukin-4 receptor subunit alpha IMMUNE SYSTEM 04/05/20 Dupilumab fab with Crystal Kappa design complexed with human IL-4 receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 2.82 X-RAY DIFFRACTION 0.304 0.245 False True IGHV3 IGKV2 Kappa None None None None None 6ao0 H NA 0 IMMUNE SYSTEM 08/15/17 CAT192 Fab Insertion Mutant H2/L2 HOMO SAPIENS homo sapiens Lord, D.M., Wei, R.R. 2.35 X-RAY DIFFRACTION 0.261 0.206 False True IGHV3 None None None None None 3cm9 C N 3 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4r4f H L 0 A protein NA hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of non-neutralizing, A32-like antibody 2.2c in complex with HIV-1 YU2 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.514 X-RAY DIFFRACTION 0.295 0.251 False True IGHV4 IGKV1 Kappa None None None None None 7lde K J 0 D protein NA glutamate receptor MEMBRANE PROTEIN 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV10 Kappa None None None None None 7jv6 C D 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (closed conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV7 Lambda None None None None None 4qy8 A B 0 Q peptide merozoite surface antigen 2 IMMUNE SYSTEM 07/24/14 Crystal Structure of anti-MSP2 Fv fragment (mAb6D8) in complex with 3D7-MSP2 14-30 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum 3d7 Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S. 1.353 X-RAY DIFFRACTION 0.165 0.152 False True IGHV14 IGKV3 Kappa 6.4e-08 -9.814126450773603 Unknown TBD 4i1n B NA 0 A protein dihydrofolate reductase OXIDOREDUCTASE/IMMUNE SYSTEM 11/21/12 R104A-ca1697 nanobody binding to the binary DHFR.folate complex LAMA GLAMA; ESCHERICHIA COLI lama glama escherichia coli Oyen, D., Steyaert, J., Barlow, J.N. 1.888 X-RAY DIFFRACTION 0.214 0.177 False True IGHV1 None None None None None 6qb4 X x 0 A protein induced myeloid leukemia cell differentiation protein mcl-1 APOPTOSIS 12/20/18 Mcl1-scFv complex with an indole acid inhibitor HOMO SAPIENS homo sapiens homo sapiens Hargreaves, D. 2.38 X-RAY DIFFRACTION 0.231 0.197 True True unknown unknown unknown None None None None None 4tnw U h 0 Q protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False unknown unknown unknown None None None None None 7ly3 D C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 Crystal structure of SARS-CoV-2 S NTD bound to S2M28 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.0 X-RAY DIFFRACTION 0.234 0.209 False True IGHV3 IGLV3 Lambda None None None None None 7k9j J N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/20 SARS-CoV-2 Spike in complex with neutralizing Fab 2H04 (three down conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Errico, J.M., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 2dwd A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 08/10/06 crystal structure of KcsA-FAB-TBA complex in Tl+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Yohannan, S., Zhou, Y. 2.6 X-RAY DIFFRACTION 0.263 0.219 False False IGHV1 IGKV5 Kappa None None None None None 7te8 B NA 0 D Hapten P0T cannabidiol BIOSYNTHETIC PROTEIN 01/04/22 CA14-CBD-DB21 ternary complex ARTIFICIAL SEQUENCES artificial sequences artificial sequences Cao, S., Zheng, N. 1.998 X-RAY DIFFRACTION 0.211 0.180 False True IGHV3 NA NA None None None None None 6qd6 A NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 6crq D E 0 A protein envelope glycoprotein gp160 VIRAL PROTEIN 03/19/18 Glutaraldehyde-treated BG505 SOSIP.664 Env in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Pallesen, J., Ward, A.B. 4.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 4hem G NA 0 A protein NA bpp VIRAL PROTEIN 10/04/12 Llama vHH-02 binder of ORF49 (RBP) from lactococcal phage TP901-1 LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 Desmyter, A., Spinelli, S., Farenc, C., Blangy, S., Bebeacua, C., van Sinderen, D., Mahony, J., Cambillau, C. 1.65 X-RAY DIFFRACTION 0.177 0.167 False True IGHV1 NA NA None None None None None 3qpx H L 0 IMMUNE SYSTEM 02/14/11 Crystal structure of Fab C2507 HOMO SAPIENS, RATTUS NORVEGICUS homo sapiens, rattus norvegicus homo sapiens, rattus norvegicus Luo, J., Teplyakov, A., Obmolova, O., Malia, T., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.264 0.225 False True IGHV5 IGKV22 Kappa None None None None None 6w0a A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Open-gate KcsA soaked in 1 mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 3.237 X-RAY DIFFRACTION 0.242 0.180 False True IGHV1 IGKV5 Kappa None None None None None 2kqm NA A 13 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1e4w H L 0 P peptide cyclic peptide IMMUNE SYSTEM 07/12/00 crossreactive binding of a circularized peptide to an anti-TGFalpha antibody Fab-fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Hahn, M., Winkler, D., Misselwitz, R., Wessner, H., Welfle, K., Zahn, G., Schneider-Mergener, J., Hoehne, W. 1.95 X-RAY DIFFRACTION 0.269 0.204 False False IGHV1 IGKV10 Kappa None None None None None 6nfn P O 0 O Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 7qn6 K NA 0 B protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7msq H L 0 A protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 05/12/21 Complex between the Fab arm of AB-3467 and the SARS-CoV-2 receptor binding domain (RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.29 X-RAY DIFFRACTION 0.245 0.194 False True IGHV4 IGKV1 Kappa None None None None None 2mcg NA 2 0 IMMUNOGLOBULIN 05/09/89 THREE-DIMENSIONAL STRUCTURE OF A LIGHT CHAIN DIMER CRYSTALLIZED IN WATER. CONFORMATIONAL FLEXIBILITY OF A MOLECULE IN TWO CRYSTAL FORMS HOMO SAPIENS homo sapiens Ely, K.R., Herron, J.N., Edmundson, A.B. 2.0 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 6mn7 I i 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 10/01/18 Cryo-EM structure of BG505.SOSIP.664 in complex with BF520.1 antigen binding fragment HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens human immunodeficiency virus 1 Williams, J.A., Lee, K.K., Overbaugh, J. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 4yhp C D 0 Q peptide h3k9me3 peptide IMMUNE SYSTEM 02/27/15 Crystal structure of 309M3-B Fab in complex with H3K9me3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Hattori, T., Dementieva, I.S., Montano, S.P., Koide, S. 2.53 X-RAY DIFFRACTION 0.250 0.211 False True IGHV3 IGLV3 Lambda 2e-09 -11.867518412372508 Unknown TBD 6phf C D 0 E protein 25 kda ookinete surface antigen IMMUNE SYSTEM 06/25/19 Pfs25 in complex with the human transmission blocking antibody 2587 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum McLeod, B.R., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.267 0.237 False True IGHV1 IGLV3 Lambda None None None None None 4krm L NA 0 K protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.655 X-RAY DIFFRACTION 0.244 0.208 False True IGHV1 None None None None None 5c7x M N 0 B protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 06/25/15 Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M. 2.95 X-RAY DIFFRACTION 0.276 0.234 False True IGHV3 IGLV3 Lambda 4e-13 -16.913816377693745 Unknown TBD 2w65 A B 0 E peptide collagen derived peptide pcii-cit1 IMMUNE SYSTEM 12/17/08 Anti citrullinated Collagen type 2 antibody acc4 in complex with a citrullinated peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Uysal, H., Bockermann, R., Nandakumar, K.S., Sehnert, B., Bajtner, E., Engstrom, A., Serre, G., Burkhardt, H., Thunnissen, M.M.G.M., Holmdahl, R. 2.21 X-RAY DIFFRACTION 0.285 0.234 False False IGHV9 IGKV1 Kappa None None None None None 7o33 H L 0 P peptide NA apsa epitope peptide IMMUNE SYSTEM 04/01/21 Crystal structure of the anti-PAS Fab 3.1 in complex with its epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Schilz, J., Skerra, A. 1.85 X-RAY DIFFRACTION 0.248 0.209 False True IGHV1 IGKV1 Kappa None None None None None 7so7 X Y 0 B protein NA toxin b TOXIN/IMMUNE SYSTEM 10/29/21 Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B CLOSTRIDIOIDES DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens clostridioides difficile Liu, J. 3.59 X-RAY DIFFRACTION 0.258 0.209 False True IGHV3 IGLV5 Lambda None None None None None 7k61 N n 0 G | F | H protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of 197bp nucleosome aided by scFv HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 2.85 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7ly0 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2M28 Local Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 1yc7 A NA 0 IMMUNE SYSTEM 12/22/04 cAbAn33 VHH fragment against VSG CAMELUS DROMEDARIUS camelus dromedarius Conrath, K., Vincke, C., Stijlemans, B., Schymkowitz, J., Wyns, L., Muyldermans, S., Loris, R. 1.6 X-RAY DIFFRACTION 0.212 0.192 False True IGHV1 None None None None None 6qfc B b 0 A protein induced myeloid leukemia cell differentiation protein mcl-1 APOPTOSIS 01/09/19 Structure of an anti-Mcl1 scFv HOMO SAPIENS homo sapiens homo sapiens Luptak, J. 1.96 X-RAY DIFFRACTION 0.219 0.193 True True unknown unknown unknown None None None None None 6e8v E F 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False True IGHV1 IGLV1 Lambda None None None None None 4rgo H L 0 S protein enterotoxin type b TOXIN/IMMUNE SYSTEM 09/30/14 Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 14G8 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Franklin, M.C., Dutta, K., Varshney, A.K., Goger, M.J., Fries, B.C. 1.8 X-RAY DIFFRACTION 0.189 0.142 False False IGHV5 IGKV5 Kappa 7.900000000000001e-09 -11.053614350904786 BLI TBD 7qnc F NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5do2 C D 0 B protein s protein VIRAL PROTEIN/IMMUNE SYSTEM 09/10/15 Complex structure of MERS-RBD bound with 4C2 antibody MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome coronavirus Li, Y., Wan, Y., Liu, P., Zhao, J., Lu, G., Qi, J., Wang, Q., Lu, X., Wu, Y., Liu, W., Yuen, K.Y., Perlman, S., Gao, G.F., Yan, J. 2.409 X-RAY DIFFRACTION 0.289 0.245 False False IGHV5 IGKV10 Kappa 1.6200000000000002e-07 -9.263879005639293 SPR TBD 7nd3 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-40 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6uyd A B 0 F protein envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C HEPATITIS C VIRUS (ISOLATE H); HOMO SAPIENS homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Zhu, J. 1.897 X-RAY DIFFRACTION 0.243 0.208 False True IGHV1 IGKV3 Kappa None None None None None 5a3i C D 0 A protein NA hemagglutinin VIRAL PROTEIN 06/01/15 Crystal Structure of a Complex formed between FLD194 Fab and Transmissible Mutant H5 Haemagglutinin INFLUENZA A VIRUS (A/VIETNAM/1203/2004(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/vietnam/1203/2004(h5n1)) Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S.R., Lin, Y.P., Walker, P.A., Collins, P.J., Monne, I., Suguitan Jr, A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J.J. 2.89 X-RAY DIFFRACTION 0.277 0.244 False False IGHV5 IGKV2 Kappa None None None None None 6w09 J N 0 F protein NA e2 glycoprotein VIRUS/IMMUNE SYSTEM 02/29/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain CHIKUNGUNYA VIRUS; HOMO SAPIENS homo sapiens homo sapiens chikungunya virus Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 7jvd H L 0 A carbohydrate BDP BETA-D-GLUCOPYRANURONIC ACID IMMUNE SYSTEM 08/20/20 Fab of 5.6 monoclonal mouse IgG1 co-crystallized with the trisaccharide form of serotype 3 pneumococcal capsular polysaccharide MUS MUSCULUS mus musculus mus musculus Ozdilek, A., Huang, J., Paschall, A.V., Babb, R., Middleton, D.R., Duke, J.A., Pirofski, L., Mousa, J.J., Avci, F.Y. 2.3 X-RAY DIFFRACTION 0.221 0.183 False True IGHV5 IGKV4 Kappa None None None None None 7kzb H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/10/20 Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Langley, D.B., Christ, D. 2.83 X-RAY DIFFRACTION 0.336 0.251 False True IGHV3 IGKV1 Kappa None None None None None 4hep G NA 0 A protein NA bpp VIRAL PROTEIN 10/04/12 Complex of lactococcal phage TP901-1 with a llama vHH (vHH17) binder (nanobody) LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 Desmyter, A., Spinelli, S., Farenc, C., Blangy, S., Bebeacua, C., van Sinderen, D., Mahony, J., Cambillau, C. 1.75 X-RAY DIFFRACTION 0.204 0.198 False True IGHV1 NA NA None None None None None 4n90 F G 0 S | B protein | protein NA | NA tumor necrosis factor receptor superfamily member 10b | tumor necrosis factor ligand superfamily member 10 Apoptosis/Immune System 10/18/13 Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Huang, X. 3.3 X-RAY DIFFRACTION 0.286 0.229 False True IGHV4 IGKV3 Kappa None None None None None 7kyo H L 0 B protein NA manganese abc transporter, atp-binding protein TRANSPORT PROTEIN/IMMUNE SYSTEM 12/08/20 PsaBC from Streptococcus pneumoniae in complex with Fab STREPTOCOCCUS PNEUMONIAE SEROTYPE 2 (STRAIN D39 / NCTC 7466); MUS MUSCULUS mus musculus mus musculus streptococcus pneumoniae serotype 2 (strain d39/ nctc 7466) Maher, M.J., Sjohamn, J. 2.85 X-RAY DIFFRACTION 0.271 0.238 False True IGHV5 IGKV3 Kappa None None None None None 6lbh C D 0 B protein NA magnesium transporter mgte TRANSPORT PROTEIN/IMMUNE SYSTEM 11/14/19 Cryo-EM structure of the MgtE Mg2+ channel under Mg2+-free conditions THERMUS THERMOPHILUS HB8; MUS MUSCULUS mus musculus mus musculus thermus thermophilus hb8 Hattori, M., Jin, F. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 1bvk E D 0 F protein lysozyme COMPLEX (HUMANIZED ANTIBODY/HYDROLASE) 09/16/98 HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Holmes, M.A., Buss, T.N., Foote, J. 2.7 X-RAY DIFFRACTION 0.297 0.208 False True IGHV4 IGKV1 Kappa 1.40e-08 -10.53 Other 20 1560463 5xqy NA F 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 6e8v J K 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False True IGHV1 IGLV1 Lambda None None None None None 7c88 H L 0 M protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 05/29/20 Complex structure of JS003 and PD-L1 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Bi, X., Shi, R., Chai, Y., Qi, J., Yan, J., Tan, S. 1.997 X-RAY DIFFRACTION 0.258 0.222 False True IGHV4 IGKV4 Kappa None None None None None 1a8j NA L 0 L Hapten PME N-L-ALPHA-ASPARTYL L-PHENYLALANINE 1-METHYL ESTER IMMUNOGLOBULIN 03/26/98 IMMUNOGLOBULIN LAMBDA LIGHT CHAIN DIMER (MCG) COMPLEX WITH ASPARTAME HOMO SAPIENS homo sapiens homo sapiens Edmundson, A.B., Manion, C.V. 2.7 X-RAY DIFFRACTION 0.380 0.220 False False IGLV2 Lambda None None None None None 7kbp B b 0 NA NA NA NA PROTEIN BINDING 10/02/20 Herceptin Diabody with R83T, E85C Mutations HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 2.3 X-RAY DIFFRACTION 0.232 0.184 True True unknown unknown unknown None None None None None 4pir J NA 0 D protein 5-hydroxytryptamine receptor 3a TRANSPORT PROTEIN 05/09/14 X-ray structure of the mouse serotonin 5-HT3 receptor MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M.B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X.-D., Poitevin, F., Vogel, H., Nury, H. 3.5 X-RAY DIFFRACTION 0.257 0.217 False True IGHV1 None None None None None 2kqn NA B 10 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5gux H L 0 B | C protein | protein NA | NA nitric oxide reductase subunit b | nitric oxide reductase subunit c MEMBRANE PROTEIN 08/31/16 Cytochrome c-dependent nitric oxide reductase (cNOR) from Pseudomonas aeruginosa in complex with xenon MUS MUSCULUS; PSEUDOMONAS AERUGINOSA PAO1 pseudomonas aeruginosa pao1 mus musculus pseudomonas aeruginosa pao1 | pseudomonas aeruginosa pao1 Ishii, S., Terasaka, E., Sugimoto, H., Shiro, Y., Tosha, T. 3.3 X-RAY DIFFRACTION 0.268 0.209 False False IGHV1 IGKV16 Kappa None None None None None 4unt NA D 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 6p9j A B 0 IMMUNE SYSTEM 06/17/20 crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab HOMO SAPIENS homo sapiens homo sapiens Dong, J., Crowe, J.E. 2.2 X-RAY DIFFRACTION 0.267 0.218 False True IGHV1 IGLV2 Lambda None None None None None 6u02 G F 0 E protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/19 CryoEM-derived model of NA-63 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.05 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6woq G H 0 F protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/25/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody HC1AM and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 3.667 X-RAY DIFFRACTION 0.277 0.227 False True IGHV1 IGKV3 Kappa None None None None None 1rzi J I 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 6m87 L K 0 K Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 08/21/18 Fab 10A6 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.609 X-RAY DIFFRACTION 0.265 0.228 False False IGHV1 IGKV4 Kappa None None None None None 2aj3 D C 0 IMMUNE SYSTEM 08/01/05 Crystal Structure of a Cross-Reactive HIV-1 Neutralizing CD4-Binding Site Antibody Fab m18 HOMO SAPIENS homo sapiens homo sapiens Prabakaran, P., Gan, J., Wu, Y.Q., Zhang, M.Y., Dimitrov, D.S., Ji, X. 2.03 X-RAY DIFFRACTION 0.269 0.225 False True IGHV4 IGKV1 Kappa None None None None None 4jdt H L 0 G protein gp120 viral protein/immune system 02/25/13 Crystal structure of chimeric germ-line precursor of NIH45-46 Fab in complex with gp120 of 93TH057 HIV-1 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Diskin, R., Bjorkman, P.J. 3.26 X-RAY DIFFRACTION 0.267 0.227 False True IGHV1 IGKV3 Kappa None None None None None 5jop H L 0 B carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 05/02/16 Crystal structure of anti-glycan antibody Fab14.22 in complex with Streptococcus pneumoniae serotype 14 tetrasaccharide at 1.75 A MUS MUSCULUS mus musculus mus musculus Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.200 0.165 False True IGHV1 IGKV1 Kappa None None None None None 6a3w D E 0 F protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 06/17/18 Complex structure of 4-1BB and utomilumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F. 2.0 X-RAY DIFFRACTION 0.215 0.185 False True IGHV5 IGLV3 Lambda None None None None None 2xa8 H L 0 IMMUNE SYSTEM 03/30/10 Crystal structure of the Fab domain of omalizumab at 2.41A HOMO SAPIENS homo sapiens homo sapiens Huang, C.H., Hung, F.H.A., Lim, C., Chang, T.W., Ma, C. 2.42 X-RAY DIFFRACTION 0.269 0.221 False False IGHV3 IGKV1 Kappa None None None None None 25c8 H L 0 L Hapten GEP N-METHYL-N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM ION CATALYTIC ANTIBODY 03/18/98 CATALYTIC ANTIBODY 5C8, FAB-HAPTEN COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gruber, K., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.292 0.229 False False IGHV14 IGKV4 Kappa None None None None None 1q1j I M 0 Q peptide gp120 v3 peptide IMMUNE SYSTEM 07/21/03 Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Stanfield, R.L., Gorny, M.K., Williams, C., Zolla-Pazner, S., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.285 0.250 False False IGHV3 IGLV1 Lambda None None None None None 5w9h E F 0 D protein mers s VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7l06 D F 0 W carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 12/11/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Manne, K., Henderson, R., Acharya, P. 3.3 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 4jdv H L 0 IMMUNE SYSTEM 02/25/13 Crystal structure of germ-line precursor of NIH45-46 Fab HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Scharf, L., Bjorkman, P.J. 1.65 X-RAY DIFFRACTION 0.203 0.174 False True IGHV1 IGKV3 Kappa None None None None None 4jo4 I M 0 IMMUNE SYSTEM 03/16/13 Crystal structure of rabbit mAb R20 Fab ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus Pan, R.M., Kong, X.P. 2.27 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV1 Kappa None None None None None 4lri C B 0 Immune System 07/19/13 Anti CMV Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Stengel, K.F. 1.65 X-RAY DIFFRACTION 0.212 0.187 False True IGHV3 IGKV2 Kappa None None None None None 5lbs I M 0 B protein envelope protein e IMMUNE SYSTEM-VIRAL PROTEIN 06/17/16 structural basis of Zika and Dengue virus potent antibody cross-neutralization ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus VANEY, M.C., ROUVINSKI, A., BARBA-SPAETH, G., REY, F.A. 2.41 X-RAY DIFFRACTION 0.217 0.194 False True IGHV3 IGKV3 Kappa None None None None None 7vne V NA 0 C | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 10/10/21 Structure of the SARS-CoV-2 spike glycoprotein in complex with a human single domain antibody n3113.1 (UUU-state) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Yang, Z., Wang, Y., Kong, Y., Jin, Y., Wu, Y., Ying, T. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2kh2 B b 6 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5bvj B A 0 IMMUNE SYSTEM 06/05/15 The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta HOMO SAPIENS homo sapiens homo sapiens Rondeau, J.M. 2.0 X-RAY DIFFRACTION 0.228 0.186 False True IGHV3 IGKV6 Kappa None None None None None 6al5 H L 0 A protein b-lymphocyte antigen cd19 IMMUNE SYSTEM 08/07/17 COMPLEX BETWEEN CD19 (N138Q MUTANT) AND B43 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 3.0 X-RAY DIFFRACTION 0.263 0.189 False True IGHV1 IGKV1 Kappa None None None None None 5vj6 O P 0 A | D protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/18/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 11.5 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5kjr H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 06/20/16 Crystal structure of the ADCC-potent antibody N60-i3 Fab in complex with HIV-1 Clade A/E gp120 W69A/S115W mutant and M48U1. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 2.98 X-RAY DIFFRACTION 0.306 0.249 False True IGHV4 IGLV2 Lambda None None None None None 2kh2 B b 44 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7tfn H L 0 A protein NA envelope glycoprotein bg505 sosip.664 - gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/06/22 Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 4.0 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV4 Lambda None None None None None 6ct7 A B 0 T peptide ace-met-asp-val-phe-met-lys-gly-leu-ser-lys IMMUNE SYSTEM 12/19/18 Fab of anti-a-synuclein antibody BIIB054 in complex with acetylated a-synuclein peptide (1-10) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Arndt, J.W. 1.903 X-RAY DIFFRACTION 0.223 0.180 False True IGHV3 IGLV3 Lambda None None None None None 7czv I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B6_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6uig H L 0 G protein NA hemagglutinin ANTIVIRAL PROTEIN 09/30/19 Crystal structure of human monoclonal antibody H7.200 in complex with H7N9 hemagglutinin HA1 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Dong, J., Crowe, J.E. 3.2 X-RAY DIFFRACTION 0.234 0.207 False True IGHV4 IGKV1 Kappa None None None None None 4gw1 B A 0 Immune system 08/31/12 cQFD Meditope MURINAE,HOMO SAPIENS; SYNTHETIC CONSTRUCT murinae,homo sapiens murinae,homo sapiens Donaldson, J.M., Zer, C., Avery, K.N., Bzymek, K.P., Horne, D.A., Williams, J.C. 2.24 X-RAY DIFFRACTION 0.226 0.182 False True IGHV2 IGKV5 Kappa 4.3e-07 -8.685503029519488 Unknown TBD 2kh2 B b 45 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 3nzh H L 0 IMMUNE SYSTEM 07/16/10 Crystal structure of anti-emmprin antibody 5F6 FAB HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.243 0.195 False True IGHV6 IGKV6 Kappa None None None None None 2mkw NA A 11 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6tcn H L 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab - crystal form II HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.3 X-RAY DIFFRACTION 0.226 0.188 False True IGHV3 IGKV1 Kappa None None None None None 7ej8 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/01/21 Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Xu, J., Cao, S., Liu, Z., Du, Y. 3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6hjx I NA 0 D protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.5 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 None None None None None 6edu J K 0 F | G protein | protein NA | NA envelope glycoprotein gp160 | t-cell surface glycoprotein cd4 IMMUNE SYSTEM 08/11/18 B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | homo sapiens Barnes, C.O., Bjorkman, P.J. 4.06 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 7po5 Z D 0 B protein NA spike glycoprotein VIRAL PROTEIN 09/08/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 47C9 antibody Fab fragment HOMO SAPIENS; HUMAN CORONAVIRUS OC43 homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4wht S T 0 s peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 6zvf H L 0 P peptide NA galectin-3 IMMUNE SYSTEM 07/24/20 Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus homo sapiens Skerra, A., Eichinger, A. 1.9 X-RAY DIFFRACTION 0.243 0.203 False True IGHV9 IGKV1 Kappa None None None None None 4k7p H L 0 IMMUNE SYSTEM 04/17/13 Generation and Characterization of a Unique Reagent that Recognizes a Panel of Recombinant Human Monoclonal Antibody Therapeutics in the Presence of Endogenous Human IgG MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Eigenbrot, C., Shia, S. 2.95 X-RAY DIFFRACTION 0.284 0.219 False True IGHV9 IGKV12 Kappa None None None None None 6ysq D NA 0 B protein NA complement c4-b,complement c4-b IMMUNE SYSTEM 04/23/20 The hC4Nb8 complement inhibitory nanobody in complex with C4b ESCHERICHIA COLI; HOMO SAPIENS homo sapiens Zarantonello, A., Laursen, N.S., Andersen, G.R. 3.3 X-RAY DIFFRACTION 0.272 0.221 False True IGHV1 NA NA None None None None None 6wwc A B 0 C peptide NA fusion peptide IMMUNE SYSTEM/VIRAL PROTEIN 05/09/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP16.02 with S48K mutation in light chain in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.563 X-RAY DIFFRACTION 0.267 0.209 False True IGHV1 IGKV1 Kappa None None None None None 6elj H L 0 IMMUNE SYSTEM 09/29/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 1.9 X-RAY DIFFRACTION 0.223 0.181 False True IGHV4 IGKV1 Kappa None None None None None 7joo K NA 0 NA NA NA NA IMMUNE SYSTEM 08/06/20 Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain LAMA GLAMA; HOMO SAPIENS lama glama Rujas, E., Sicard, T., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.297 0.241 False True unknown unknown unknown None None None None None 7zr9 D E 0 C protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/03/22 OMI-2 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4ma3 B A 0 IMMUNE SYSTEM 08/15/13 Crystal structure of anti-hinge rabbit antibody C2095 ORYCTOLAGUS CUNICULUS, HOMO SAPIENS oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens Malia, T., Teplyakov, A., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 IGKV1 Kappa None None None None None 5ug0 D C 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/06/17 Human antibody H2897 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Raymond, D.D., Caradonna, T., Schmidt, A.G., Harrison, S.C. 3.4 X-RAY DIFFRACTION 0.278 0.240 False True IGHV3 IGKV3 Kappa None None None None None 6cmo H L 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 03/05/18 Rhodopsin-Gi complex ESCHERICHIA COLI; HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; UNIDENTIFIED unidentified unidentified homo sapiens | rattus norvegicus Kang, Y., Xu, H.E. 4.5 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 7wd8 E F 0 B | A protein | peptide NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike SD1 in complex with S3H3 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 4.3 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 5uy3 H L 0 IMMUNE SYSTEM 02/23/17 Crystal structure of human Fab PGT144, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Lee, J.H., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.282 0.241 False True unknown IGKV2 Kappa None None None None None 3ifo A B 0 Q peptide amyloid beta a4 protein IMMUNE SYSTEM 07/24/09 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Weis, W.I., Feinberg, H., Basi, G.S., Schenk, D. 2.15 X-RAY DIFFRACTION 0.218 0.162 False True IGHV8 IGKV1 Kappa 5.45e-08 -9.9 SPR 25 19923222 7xlt H L 0 B | A nucleic-acid | nucleic-acid NA | NA rna | dna DNA-RNA HYBRID 04/22/22 Cryo-EM Structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids MUS MUSCULUS; ARABIDOPSIS mus musculus mus musculus arabidopsis | arabidopsis Li, Q., Lin, C., Luo, Z., Li, H. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6ol7 K J 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV5 IGKV8 Kappa None None None None None 4weu E NA 0 A protein k88 fimbrial protein ad CELL ADHESION 09/11/14 Co-complex structure of the F4 fimbrial adhesin FaeG variant ad with llama single domain antibody V3 ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Moonens, K., Van den Broeck, I., Pardon, E., De Kerpel, M., Remaut, H., De Greve, H. 2.61 X-RAY DIFFRACTION 0.243 0.204 False True IGHV1 5.7e-06 -7.154266732276501 SPR TBD 5jo5 E F 0 IMMUNE SYSTEM 05/02/16 Crystal structure of 10E8 gHV-gLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.263 0.233 False True IGHV3 IGLV3 Lambda None None None None None 7bu8 H L 0 A protein genome polyprotein VIRUS 05/13/20 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6bzv G H 0 L peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.654 X-RAY DIFFRACTION 0.241 0.199 False True IGHV3 IGKV3 Kappa None None None None None 4las H L 0 H Hapten 1WF 4-[(2S)-2-(methylamino)propyl]phenol IMMUNE SYSTEM 06/20/13 Crystal structures of a therapeutic single chain antibody in the free Form and in complex with amphetamine and 4-hydroxymethamphetamine MUS MUSCULUS mus musculus mus musculus mus musculus Celical, R., Gokulan, K., Peterson, E.C., Varughese, K.I. 2.33 X-RAY DIFFRACTION 0.238 0.160 False True IGHV3 IGKV4 Kappa None None None None None 7ckz N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 CELL CYCLE 07/20/20 Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens | homo sapiens Yan, W., Shao, Z. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5yd3 A a 0 B peptide epitope peptide IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.184 0.136 True True unknown unknown unknown None None None None None 7shz C D 0 A protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with HAE HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.236 0.186 False True IGHV3 IGKV1 Kappa None None None None None 6n7u A B 0 IMMUNE SYSTEM 11/28/18 apo-BDBV223 Fab HOMO SAPIENS homo sapiens homo sapiens King, L.B., West, B.R., Saphire, E.O. 2.03 X-RAY DIFFRACTION 0.250 0.235 False True IGHV4 IGKV3 Kappa None None None None None 6nbh N NA 0 A | B protein | protein NA | NA gs protein alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/07/18 Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y. 3.5 ELECTRON MICROSCOPY False True IGHV3 None None None None None 7lm9 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/05/21 Crystal structure of SARS-CoV spike protein receptor-binding domain in complex with a cross-neutralizing antibody CV38-142 Fab isolated from COVID-19 patient SARS CORONAVIRUS MA15; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus ma15 Liu, H., Yuan, M., Zhu, X., Wilson, I.A. 1.53 X-RAY DIFFRACTION 0.192 0.170 False True IGHV5 IGKV1 Kappa None None None None None 7t0i B A 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-39 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.1 X-RAY DIFFRACTION 0.225 0.180 False True IGHV7 IGKV8 Kappa None None None None None 7lvu B NA 0 NA NA NA NA IMMUNE SYSTEM 02/26/21 Structure of RSV F-directed VHH Cl184 LAMA GLAMA lama glama Hsieh, C.-L., McLellan, J.S. 1.94 X-RAY DIFFRACTION 0.233 0.208 False True IGHV1 NA NA None None None None None 5iop D C 0 IMMUNE SYSTEM 03/08/16 Cetuximab Fab in complex with 4-bromophenylalanine meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.499 X-RAY DIFFRACTION 0.226 0.177 False True IGHV2 IGKV5 Kappa 2.9e-05 -6.190396711462486 Unknown TBD 4ioi B A 0 H | E protein | protein NA | NA immunoglobulin g-binding protein a | protein l immune system 01/07/13 Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC HOMO SAPIENS; STAPHYLOCOCCUS AUREUS; FINEGOLDIA MAGNA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens staphylococcus aureus | finegoldia magna Bzymek, K.P., Zer, C., Avery, K.N., Williams, J.C. 1.95 X-RAY DIFFRACTION 0.204 0.176 False True IGHV3 IGKV1 Kappa None None None None None 7eaj F L 0 1 | 3 protein | protein NA | NA vp1 | vp3 VIRUS 03/07/21 Echovirus3 empty expanded particle in complex with 5G3 fab ECHOVIRUS E3; MUS MUSCULUS mus musculus mus musculus echovirus e3 | echovirus e3 Feng, R. 4.1 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 6yx9 H L 0 A protein NA adiponectin receptor protein 2 MEMBRANE PROTEIN 04/30/20 Cryogenic human adiponectin receptor 2 (ADIPOR2) at 2.4 A resolution determined by Serial Crystallography (SSX) using CrystalDirect HOMO SAPIENS homo sapiens homo sapiens homo sapiens Healey, R.D., Basu, S., Humm, A.S., Leyrat, C., Dupeux, F., Pica, A., Granier, S., Marquez, J.A. 2.404 X-RAY DIFFRACTION 0.248 0.207 False True IGHV1 IGKV12 Kappa None None None None None 3mly H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with a UR29 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 1.7 X-RAY DIFFRACTION 0.215 0.181 False False IGHV4 IGLV1 Lambda None None None None None 3mlv H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with an NOF V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.48 X-RAY DIFFRACTION 0.342 0.233 False False IGHV5 IGLV3 Lambda None None None None None 5dhx L l 0 M protein protein rev IMMUNE SYSTEM 08/31/15 HIV-1 Rev NTD dimers with variable crossing angles ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus human immunodeficiency virus 1 DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C. 2.9 X-RAY DIFFRACTION 0.273 0.246 True True unknown unknown unknown None None None None None 6xjq C D 0 B nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - alkylated form with biotinylated epoxide substrate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 1.708 X-RAY DIFFRACTION 0.213 0.189 False True IGHV3 IGKV1 Kappa None None None None None 7k5x M m 0 C | B | D protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of a chromatosome containing human linker histone H1.0 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 2.93 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7rth i NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 5bzd D C 0 IMMUNE SYSTEM 06/11/15 Crystal Structure of PCDN-27A, an antibody from the PCDN family of HIV-1 antibodies HOMO SAPIENS homo sapiens homo sapiens Garces, F., WILSON, I.A. 2.7 X-RAY DIFFRACTION 0.247 0.211 False True IGHV4 IGKV3 Kappa None None None None None 1oar J N 0 IMMUNE SYSTEM 01/21/03 Fv IgE SPE-7 in complex with Alizarin Red RATTUS RATTUS rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.23 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 IGLV1 Lambda 4.00e-08 Other 20 12610298 6xul E F 0 NA NA NA NA ANTITUMOR PROTEIN 01/20/20 Apo Ab 5b1 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.230 0.168 False True IGHV3 IGLV1 Lambda None None None None None 7d03 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with FabP5A-2G7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV2 Lambda None None None None None 2mkw NA A 12 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6dfg G J 0 C protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 05/14/18 BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Steichen, J.M., Schief, W.R., Ward, A.B. 4.42 ELECTRON MICROSCOPY False True unknown IGLV3 Lambda None None None None None 7e8c a Z 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 6mh2 D C 0 IMMUNE SYSTEM 09/17/18 Structure of Herceptin Fab without antigen HOMO SAPIENS homo sapiens homo sapiens Luthra, A., Langley, D.B., Christie, M., Christ, D. 2.8 X-RAY DIFFRACTION 0.306 0.251 False True IGHV3 IGKV1 Kappa None None None None None 5f96 H L 0 G protein clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 12/09/15 Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.12 in complex with HIV-1 clade A/E 93TH057 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.2407 X-RAY DIFFRACTION 0.233 0.190 False True unknown IGKV3 Kappa None None None None None 4unv NA A 0 IMMUNE SYSTEM 05/30/14 Covalent dimer of lambda variable domains HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S., Landau, M., Ryan, C., Whitelegge, J., Sawaya, M., Eisenberg, D.S. 1.6 X-RAY DIFFRACTION 0.25793 0.19290 False True IGLV2 Lambda None None None None None 5sx5 H L 0 N protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 08/09/16 Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sickmier, E.A. 2.5 X-RAY DIFFRACTION 0.250 0.226 False True IGHV4 IGKV1 Kappa 1.15e-09 -12.195390134749905 SPR TBD 5b8c H G 0 I protein programmed cell death protein 1 IMMUNE SYSTEM 06/14/16 High resolution structure of the human PD-1 in complex with pembrolizumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Horita, S., Shimamura, T., Iwata, S., Nomura, N. 2.146 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV3 Kappa None None None None None 2ltq C B 5 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 1u92 B A 0 C peptide gp41 peptide analog IMMUNE SYSTEM 08/09/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide Analog E-[Dap]-DKWQS (cyclic) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.249 0.225 False False IGHV2 IGKV1 Kappa None None None None None 6wj1 G I 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 04/11/20 Crystal structure of Fab 54-4H03 bound to H1 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Wilson, I.A. 3.503 X-RAY DIFFRACTION 0.232 0.179 False True IGHV6 IGKV3 Kappa None None None None None 6hjq K L 0 F | E protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/04/18 Structure of Full-length Influenza Hemagglutinin (A/duck/Alberta/35/76) in complex with FISW84 Fab Fragment HOMO SAPIENS; INFLUENZA A VIRUS (STRAIN A/DUCK/ALBERTA/35/1976 H1N1) homo sapiens homo sapiens influenza a virus (straina/duck/alberta/35/1976 h1n1) | influenza a virus (straina/duck/alberta/35/1976 h1n1) Benton, D.J., Rosenthal, P.B. 4.1 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 7oly H L 0 C protein NA activin receptor type-2b SIGNALING PROTEIN 05/20/21 Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hakansson, M., Rose, N.C., Castonguay, R., Logan, D.T., Krishnan, L. 3.265 X-RAY DIFFRACTION 0.269 0.234 False True IGHV4 IGKV4 Kappa None None None None None 1ggb H L 0 IMMUNOGLOBULIN 07/19/93 MAJOR ANTIGEN-INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY MUS MUSCULUS mus musculus mus musculus Takimoto-Kamimura, M., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.200 False True IGHV8 IGKV3 Kappa None None None None None 2kqn NA A 3 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5kov I i 0 G protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 7k8t H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Malyutin, A.G., Barnes, C.O., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6w2b B C 0 A protein sodium-dependent serotonin transporter TRANSPORT PROTEIN 03/05/20 Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Navratna, V., Yang, D. 4.7 X-RAY DIFFRACTION 0.293 0.259 False True IGHV1 IGKV6 Kappa None None None None None 6ev2 E F 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan in complex with laminarihexaose MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Duebel, S., Blankenfeldt, W., Rau, U. 2.403 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV4 Kappa None None None None None 3mo1 B A 0 IMMUNE SYSTEM 04/22/10 Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment MUS MUSCULUS,HOMO SAPIENS mus musculus,homo sapiens mus musculus,homo sapiens Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 1.8 X-RAY DIFFRACTION 0.221 0.187 False True IGHV9 IGKV8 Kappa None None None None None 3qa3 K J 0 L protein integrin alpha-m IMMUNE SYSTEM/ cell adhesion 01/10/11 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 3.0 X-RAY DIFFRACTION 0.224 0.194 False False IGHV14 IGKV8 Kappa None None None None None 4qlr B NA 0 IMMUNE SYSTEM 06/13/14 Llama nanobody n02 raised against EAEC T6SS TssM LAMA GLAMA lama glama Nguyen, V.S., Desmyter, A., Le, T.T.H., Durand, E., Kellenberger, C., Douzi, B., Spinelli, S., Cascales, E., Cambillau, C., Roussel, A. 1.7 X-RAY DIFFRACTION 0.251 0.205 False True IGHV1 None None None None None 3chn A L 1 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 5vcn D C 0 B protein peptidase 1 IMMUNE SYSTEM 03/31/17 THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 5H8 MUS MUSCULUS; DERMATOPHAGOIDES PTERONYSSINUS mus musculus mus musculus dermatophagoides pteronyssinus Osinski, T., Majorek, K.A., Pomes, A., Offermann, L.R., Osinski, S., Glesner, J., Vailes, L.D., Chapman, M.D., Minor, W., Chruszcz, M. 3.0 X-RAY DIFFRACTION 0.265 0.219 False True IGHV2 IGKV10 Kappa None None None None None 4u6h C D 0 J protein protein l1 IMMUNE SYSTEM 07/29/14 Vaccinia L1/M12B9-Fab complex VACCINIA VIRUS; MUS MUSCULUS mus musculus mus musculus vaccinia virus Matho, M.H., Schlossman, A., Zajonc, D.M. 3.1 X-RAY DIFFRACTION 0.265 0.209 False False IGHV1 IGKV1 Kappa 9.100000000000001e-11 -13.698318432538965 SPR TBD 6fv0 F NA 0 A protein kinesin light chain 1,torsin-1a MOTOR PROTEIN 02/28/18 Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of torsinA MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Pernigo, S., Dodding, M.P., Steiner, R.A. 2.29 X-RAY DIFFRACTION 0.245 0.208 False True IGHV3 None None None None None 3qwo A B 0 C protein motavizumab epitope scaffold Immune System 02/28/11 Crystal structure of a motavizumab epitope-scaffold bound to motavizumab Fab MUS MUSCULUS; STAPHYLOCOCCUS AUREUS mus musculus mus musculus staphylococcus aureus McLellan, J.S., Kwong, P.D. 1.9 X-RAY DIFFRACTION 0.231 0.188 False True IGHV2 IGKV1 Kappa 8.70e-08 -9.63 SPR 21549714 3iet D C 0 Q peptide podoplanin IMMUNE SYSTEM 07/23/09 Crystal Structure of 237mAb with antigen MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V., Borisova, S.N. 2.2 X-RAY DIFFRACTION 0.271 0.227 False True IGHV6 IGKV1 Kappa 1.4e-07 -9.350354316900614 Unknown TBD 4jy4 B A 0 IMMUNE SYSTEM 03/29/13 Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Diwanji, D.C., Burton, D.R., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.234 0.189 False True IGHV4 unknown unknown None None None None None 1i9i H L 0 IMMUNE SYSTEM 03/20/01 NATIVE CRYSTAL STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus Valjakka, J., Takkinenz, K., Teerinen, T., Soderlund, H., Rouvinen, J. 2.72 X-RAY DIFFRACTION 0.252 0.195 False True IGHV5 IGKV1 Kappa None None None None None 1mak NA A 2 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7s8m E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/18/21 CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14 HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Cao, C., Fay, J.F., Gumpper, R.H., Roth, B.L. 2.54 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6iuv H L 0 A protein hemagglutinin IMMUNE SYSTEM 11/30/18 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 3C11 INFLUENZA A VIRUS (A/HONG KONG/482/97(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/hong kong/482/97(h5n1)) Wang, P., Zuo, Y., Sun, J., Zhang, L., Wang, X. 2.332 X-RAY DIFFRACTION 0.246 0.207 False True IGHV5 IGKV2 Kappa None None None None None 7s11 H L 0 C protein NA t-cell surface protein tactile IMMUNE SYSTEM 08/31/21 Crystal structure of Fab in complex with mouse CD96 monomer MUS MUSCULUS; RATTUS rattus rattus mus musculus Lee, P.S., Chau, B., Strop, P. 2.58 X-RAY DIFFRACTION 0.279 0.226 False True IGHV2 IGLV1 Lambda None None None None None 5kzc B D 0 C protein engineered outer domain of gp120 IMMUNE SYSTEM 07/24/16 Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Julien, J.-P., Jardine, J.G., Diwanji, D., Schief, W.R., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.274 0.223 False True unknown IGKV3 Kappa None None None None None 1cbv H L 0 D nucleic-acid dna (5'-d(*tp*tp*t)-3') IMMUNE SYSTEM/DNA 03/16/93 AN AUTOANTIBODY TO SINGLE-STRANDED DNA: COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF THE UNLIGANDED FAB AND A DEOXYNUCLEOTIDE-FAB COMPLEX MUS MUSCULUS mus musculus mus musculus Herron, J.N., He, X.M., Ballard, D.W., Blier, P.R., Pace, P.E., Bothwell, A.L., Voss Jr., E.W., Edmundson, A.B. 2.66 X-RAY DIFFRACTION unknown 0.191 False True IGHV10 IGKV1 Kappa None None None None None 1qfw H L 0 A protein gonadotropin alpha subunit IMMUNE SYSTEM 04/15/99 TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Tegoni, M., Spinelli, S., Cambillau, C. 3.5 X-RAY DIFFRACTION 0.310 0.260 False True IGHV1 IGKV3 Kappa 1e-08 -10.913952715282035 Unknown TBD 5fv1 NA M 0 W protein vascular endothelial growth factor a 02/02/16 Crystal structure of hVEGF in complex with VK domain antibody HOMO SAPIENS homo sapiens homo sapiens Chung, C., Walker, A. 2.7 X-RAY DIFFRACTION 0.26056 0.20536 False True IGKV1 Kappa None None None None None 6uvo H L 0 D peptide major surface glycoprotein g VIRAL PROTEIN, IMMUNE SYSTEM 11/03/19 Structure of antibody 3G12 bound to the central conserved domain of RSV G HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2) homo sapiens homo sapiens human respiratory syncytial virus a (straina2) Fedechkin, S.O., George, N.L., Nunez Castrejon, A.M., Dillen, J., Kauvar, L.M., DuBois, R.M. 2.9 X-RAY DIFFRACTION 0.209 0.193 False True IGHV4 IGKV3 Kappa None None None None None 6o23 C D 0 E peptide circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 2243 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.0 X-RAY DIFFRACTION 0.224 0.186 False True IGHV3 IGKV1 Kappa None None None None None 5ukp H L 0 IMMUNE SYSTEM 01/23/17 Structure of unliganded anti-gp120 CD4bs antibody DH522.1 Fab MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I. 2.0 X-RAY DIFFRACTION 0.236 0.192 False True IGHV4 IGLV2 Lambda None None None None None 4c57 C NA 0 A protein cyclin-g-associated kinase TRANSFERASE 09/10/13 Structure of GAK kinase in complex with a nanobody HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Chaikuad, A., Keates, T., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S. 2.55 X-RAY DIFFRACTION 0.2281 0.1776 False False IGHV3 None None None None None 4bkl A B 0 E | G | F peptide | peptide | peptide NA | NA | NA j1 epitope | j1 epitope | j1 epitope 04/26/13 Crystal structure of the arthritogenic antibody M2139 (Fab fragment) in complex with the triple-helical J1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus | mus musculus | mus musculus Raposo, B., Dobritzsch, D., Ge, C., Ekman, D., Lindh, I., Foerster, M., Uysal, H., Schneider, G., Holmdahl, R. 3.25 X-RAY DIFFRACTION 0.26270 0.22175 False False IGHV1 IGKV3 Kappa 2.74e-07 -8.952510007908053 Unknown TBD 3v0v H L 0 IMMUNE SYSTEM 12/08/11 Fab WN1 222-5 unliganded MUS MUSCULUS mus musculus mus musculus Gomery, K., Evans, S.V. 2.13 X-RAY DIFFRACTION 0.284 0.238 False False IGHV7 IGKV11 Kappa None None None None None 5i0z A NA 0 IMMUNE SYSTEM 02/04/16 Crystal structure of the single domain catalytic antibody 3D8-VH MUS MUSCULUS mus musculus Park, S.Y., Kim, J.S. 1.9 X-RAY DIFFRACTION 0.262 0.218 False True IGHV1 None None None None None 1xcq B A 0 P | L peptide | protein NA | NA capsid protein c | protein l IMMUNE SYSTEM 09/03/04 Complex HCV core-Fab 19D9D6-Protein L mutant (D55A,L57H,Y64W) in space group P21 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | finegoldia magna Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 3.5 X-RAY DIFFRACTION 0.264 0.192 False False IGHV9 IGKV8 Kappa None None None None None 6ous M N 0 B | A protein | protein NA | NA fusion glycoprotein f1 fused with fibritin trimerizationdomain | fusion glycoprotein f2 VIRAL PROTEIN/Immune system 05/05/19 Structure of fusion glycoprotein from human respiratory syncytial virus HUMAN RESPIRATORY SYNCYTIAL VIRUS A2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a2, humanimmunodeficiency virus 1 | human respiratory syncytial virus a2 Su, H.P. 3.4 X-RAY DIFFRACTION 0.275 0.245 False True IGHV3 IGKV1 Kappa None None None None None 7lop X Y 0 Z protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/10/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.246 X-RAY DIFFRACTION 0.268 0.220 False True IGHV1 IGKV3 Kappa None None None None None 2kh2 B b 62 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 2nxy D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein(S334A) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.231 0.181 False True IGHV1 IGKV3 Kappa 7.90e-07 SPR 17301785 6xob Q R 0 H protein NA togavirin Virus/Immune System 07/06/20 CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP with Fab EEEV-143. EASTERN EQUINE ENCEPHALITIS VIRUS; HOMO SAPIENS homo sapiens homo sapiens eastern equine encephalitis virus Binshtein, E., Crowe, J.E. 8.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7dpm G H 0 I protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/20/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M. 3.304 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGKV1 Kappa None None None None None 7tn0 B A 0 I protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/20/22 SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., McCallum, M., Veesler, D., Nix, J.C., Croll, T.I., Dillen, J.R., Czudnochowski, N. 2.85 X-RAY DIFFRACTION 0.268 0.230 False True IGHV1 IGKV3 Kappa None None None None None 3bqu B A 0 IMMUNE SYSTEM 12/20/07 Crystal Structure of the 2F5 Fab'-3H6 Fab Complex HOMO SAPIENS; MUS MUSCULUS homo sapiens homo sapiens Bryson, S., Julien, J.-P., Isenman, D.E., Kunert, R., Katinger, H., Pai, E.F. 3.0 X-RAY DIFFRACTION 0.295 0.276 False False IGHV2 IGKV1D Kappa None None None None None 5a8h J I 0 G protein NA hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 23.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6udj D E 0 P protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 2.5 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 1mak NA A 12 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7wlc H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/13/22 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5itb H L 0 IMMUNE SYSTEM 03/16/16 Crystal structure of the anti-RSV F Fab 14N4 HOMO SAPIENS homo sapiens homo sapiens Mousa, J.J., Crowe, J.E. 2.0 X-RAY DIFFRACTION 0.214 0.194 False True IGHV3 IGKV1 Kappa None None None None None 6x3u J I 0 B protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.49 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 4g80 C D 0 J protein voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (WT, 3.8 A) HOMO SAPIENS; CIONA INTESTINALIS homo sapiens homo sapiens ciona intestinalis Li, Q. 3.58 X-RAY DIFFRACTION 0.292 0.248 False True IGHV3 IGKV1 Kappa None None None None None 7ld1 H L 0 B protein NA spike glycoprotein IMMUNE SYSTEM 01/12/21 Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1047 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 6vzi H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 02/28/20 Crystal Structure of HIV-1 CAP256 RnS-3mut-2G-SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.716 X-RAY DIFFRACTION 0.276 0.229 False True IGHV4 unknown unknown None None None None None 2e27 H L 0 H Hapten AB0 3,7:6,10:9,14-TRIANHYDRO-2,5,11,12,13-PENTADEOXY-4-O-(METHOXYMETHYL)-L-ARABINO-L-ALLO-TETRADEC-12-ENONIC ACID IMMUNE SYSTEM 11/08/06 Crystal structure of Fv fragment of anti-ciguatoxin antibody complexed with ABC-ring of ciguatoxin MUS MUSCULUS mus musculus mus musculus mus musculus Yokota, A., Tanaka, Y., Tsumoto, K. 1.7 X-RAY DIFFRACTION 0.210 0.198 False True IGHV1 IGKV19 Kappa 4.5000000000000005e-10 -12.751299583055715 Unknown TBD 1c5b H L 0 IMMUNE SYSTEM 11/08/99 DECARBOXYLASE CATALYTIC ANTIBODY 21D8 UNLIGANDED FORM MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Hotta, K., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.238 0.188 False True IGHV1 IGKV9 Kappa None None None None None 3uc0 H L 0 A protein envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 10/25/11 Crystal structure of domain I of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 DENGUE VIRUS 4; PAN TROGLODYTES pan troglodytes pan troglodytes dengue virus 4 Cockburn, J.J.B., Stura, E.A., Navarro-Sanchez, M.E., Rey, F.A. 2.71 X-RAY DIFFRACTION 0.252 0.220 False True IGHV4 IGKV1 Kappa 1.30e-09 -12.6 Other 37 22139356 7ksg F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/22/20 SARS-CoV-2 spike in complex with nanobodies E SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; CAMELUS BACTRIANUS camelus bactrianus severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 3.33 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6qn8 G I 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV Fab B13 BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.12 X-RAY DIFFRACTION 0.267 0.235 False True IGHV1 IGLV1 Lambda None None None None None 2rhe NA A 0 IMMUNOGLOBULIN 06/13/83 STRUCTURE OF A NOVEL BENCE-JONES PROTEIN (RHE) FRAGMENT AT 1.6 ANGSTROMS RESOLUTION HOMO SAPIENS homo sapiens Fureyjunior, W., Wang, B.C., Yoo, C.S., Sax, M. 1.6 X-RAY DIFFRACTION unknown 0.149 False True unknown unknown unknown None None None None None 7shu C D 0 A protein NA immunoglobulin heavy constant epsilon IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with omalizumab variant C02 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 2.75 X-RAY DIFFRACTION 0.275 0.220 False True IGHV3 IGKV1 Kappa None None None None None 4y5x D E 0 F protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 3.15 X-RAY DIFFRACTION 0.241 0.201 False True IGHV3 IGLV1 Lambda None None None None None 2adg B A 0 IMMUNE SYSTEM 07/20/05 Crystal structure of monoclonal anti-CD4 antibody Q425 MUS MUSCULUS mus musculus mus musculus Zhou, T., Hamer, D.H., Hendrickson, W.A., Sattentau, Q.J., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.244 0.203 False False IGHV5 IGKV17 Kappa None None None None None 2otu H G 0 S peptide peptide antigen IMMUNE SYSTEM 02/09/07 Crystal structure of Fv polyglutamine complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Li, P. 1.68 X-RAY DIFFRACTION 0.214 0.200 False True IGHV5 IGLV3 Lambda None None None None None 2x1o A NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama Van den Abbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., Van Loo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.34 X-RAY DIFFRACTION 0.24007 0.21135 False True IGHV1 None None None None None 6b0e B A 0 E protein 25 kda ookinete surface antigen IMMUNE SYSTEM 09/14/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1260 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum Scally, S.W., McLeod, B., Bosch, A., King, C.R., Julien, J.P. 3.3 X-RAY DIFFRACTION 0.280 0.230 False True IGHV1 IGKV2 Kappa 4.1e-08 -10.077965960666114 BLI TBD 3f12 D C 0 IMMUNE SYSTEM 10/27/08 Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus HOMO SAPIENS homo sapiens homo sapiens Thomson, C.A., Bryson, S., McLean, G.R., Creagh, A.L., Pai, E.F., Schrader, J.W. 2.95 X-RAY DIFFRACTION 0.320 0.300 False True IGHV3 IGKV3 Kappa None None None None None 7ebr E F 0 C | A protein | protein NA | NA capsid protein vp2 | capsid protein vp1 VIRUS 03/10/21 EV-D68 in complex with 2H12 Fab (state S2) HUMAN ENTEROVIRUS D68; MUS MUSCULUS mus musculus mus musculus human enterovirus d68 | human enterovirus d68 Xu, C., Cong, Y. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV9 Kappa None None None None None 7pqz A B 0 E protein NA spike protein s1 VIRAL PROTEIN 09/20/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FI-3A and FD-11A Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.2 X-RAY DIFFRACTION 0.240 0.201 False True IGHV3 IGLV1 Lambda None None None None None 7orb A B 0 R protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the L452R mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-75 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.5 X-RAY DIFFRACTION 0.251 0.213 False True IGHV3 IGKV1 Kappa None None None None None 7klh I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 10/30/20 SARS-CoV-2 RBD in complex with Fab 15033-7 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 3.0 X-RAY DIFFRACTION 0.284 0.256 False True IGHV3 IGKV1 Kappa None None None None None 4xp5 H L 0 A protein dopamine transporter, isoform b transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55 DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Gouaux, E., Penmatsa, A., Wang, K. 3.3 X-RAY DIFFRACTION 0.286 0.245 False True IGHV5 IGKV4 Kappa None None None None None 6nis H L 0 IMMUNE SYSTEM 12/31/18 Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ24 isolated following ZPIV vaccination HOMO SAPIENS homo sapiens homo sapiens Sankhala, R.S., Dussupt, V., Donofrio, G., Choe, M., Modjarrad, K., Michael, N.L., Krebs, S.J., Joyce, M.G. 2.113 X-RAY DIFFRACTION 0.200 0.165 False True IGHV4 IGLV1 Lambda None None None None None 3u79 NA E 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 2vdr H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain chimera peptide, LGGAKQRGDV HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.4 X-RAY DIFFRACTION 0.193 0.148 False False IGHV14 IGKV14 Kappa None None None None None 4jfy H L 0 immune system 02/28/13 Apo structure of phosphotyrosine (pYAb) scaffold ESCHERICHIA COLI Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 2.63 X-RAY DIFFRACTION 0.236 0.188 False True IGHV3 IGKV3 Kappa None None None None None 7ki6 G F 0 E protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 10/23/20 Structure of the HeV F glycoprotein in complex with the 1F5 neutralizing antibody HENDRA HENIPAVIRUS; MUS MUSCULUS mus musculus mus musculus hendra henipavirus Dang, H.V., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 6ww2 K NA 0 NA NA NA NA MEMBRANE PROTEIN 05/07/20 Structure of human Frizzled5 by fiducial-assisted cryo-EM HOMO SAPIENS; SYNTHETIC CONSTRUCT; ESCHERICHIA COLI synthetic construct Tsutsumi, N., Jude, K.M., Gati, C., Garcia, K.C. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4ot1 H L 0 A protein envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 02/13/14 Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by the Neutralizing Human Antibody SM5-1 HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS homo sapiens homo sapiens human cytomegalovirus Diestel, U., Muller, Y.A. 2.11 X-RAY DIFFRACTION 0.231 0.171 False True IGHV1 IGLV1 Lambda None None None None None 2kqm NA A 1 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1vhp A NA 15 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7ki4 D C 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 10/23/20 Structure of the NiV F glycoprotein in complex with the 12B2 neutralizing antibody NIPAH VIRUS; MUS MUSCULUS mus musculus mus musculus nipah virus Dang, H.V., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV12 Kappa None None None None None 1maj NA A 7 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6y9b I M 0 A protein metalloreductase steap1 MEMBRANE PROTEIN 05/20/20 Cryo-EM structure of trimeric human STEAP1 bound to three Fab120.545 fragments HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Oosterheert, W., Gros, P. 2.97 ELECTRON MICROSCOPY False True IGHV3 IGKV8 Kappa None None None None None 3q6f B A 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 3.192 X-RAY DIFFRACTION 0.243 0.199 False False IGHV3 IGLV3 Lambda None None None None None 7uap H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 03/13/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1520 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 4nbx B NA 0 A protein tcda IMMUNE SYSTEM 10/23/13 Crystal Structure of Clostridium difficile Toxin A fragment TcdA-A1 Bound to A20.1 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 1.75 X-RAY DIFFRACTION 0.229 0.195 False True IGHV1 None None None None None 6wgj A B 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.9 X-RAY DIFFRACTION 0.289 0.235 False True IGHV3 IGKV2 Kappa None None None None None 4yaq H L 0 L carbohydrate NAG polysaccharide IMMUNE SYSTEM 02/17/15 Crystal structure of a computationally optimized PG9 mutant HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murrell, S., Julien, J.P., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.238 0.204 False True IGHV3 IGLV2 Lambda None None None None None 1i8m H L 0 T nucleic-acid 5'-d(*tp*tp*tp*tp*t)-3' IMMUNE SYSTEM/DNA 03/14/01 CRYSTAL STRUCTURE OF A RECOMBINANT ANTI-SINGLE-STRANDED DNA ANTIBODY FRAGMENT COMPLEXED WITH DT5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Tanner, J.J., Komissarov, A.A., Deutscher, S.L. 2.1 X-RAY DIFFRACTION 0.258 0.220 False True IGHV1 IGKV12 Kappa 2.7e-06 -7.5969790708218685 Unknown TBD 4jfx H L 0 P peptide phosphopeptide immune system 02/28/13 Structure of phosphotyrosine (pTyr) scaffold bound to pTyr peptide ESCHERICHIA COLI; SYNTHETIC CONSTRUCT Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 1.95 X-RAY DIFFRACTION 0.202 0.163 False True IGHV3 IGKV3 Kappa 3.6000000000000005e-07 -8.790776227275865 Unknown TBD 6ir2 B NA 0 A protein mcherry fluorescent protein FLUORESCENT PROTEIN 11/09/18 Crystal structure of red fluorescent protein mCherry complexed with the nanobody LaM2 at 1.4 Angstron resolution ANAPLASMA MARGINALE; CAMELUS BACTRIANUS camelus bactrianus anaplasma marginale Ding, Y., Wang, Z.Y., Hu, R.T., Chen, X. 1.393 X-RAY DIFFRACTION 0.216 0.195 False True IGHV1 None None None None None 3u79 NA D 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 6nb5 H L 0 IMMUNE SYSTEM 12/06/18 Crystal structure of anti- MERS-CoV human neutralizing LCA60 antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Walls, A.J., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Gopal, R., Dai, M., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.0 X-RAY DIFFRACTION 0.283 0.228 False True IGHV3 IGLV2 Lambda None None None None None 6pxh H L 0 B protein mers-cov s1-ntd IMMUNE SYSTEM/Viral protein 07/26/19 Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Wang, N., McLellan, J.S. 2.3 X-RAY DIFFRACTION 0.213 0.180 False True IGHV1 IGKV3 Kappa None None None None None 3eyv H L 0 H carbohydrate FUC polysaccharide IMMUNE SYSTEM 10/22/08 Anti-Lewis Y Fab fragment with Lewis Y antigen in the presence of zinc ions MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Farrugia, W., Scott, A.M., Ramsland, P.A. 2.5 X-RAY DIFFRACTION 0.262 0.210 False True IGHV5 IGKV1 Kappa None None None None None 1mre H L 0 L nucleic-acid GDP GUANOSINE-5'-DIPHOSPHATE IMMUNOGLOBULIN 06/13/94 PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB-MONONUCLEOTIDE COMPLEXES MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Cygler, M. 2.3 X-RAY DIFFRACTION unknown 0.192 False True IGHV1 IGKV1 Kappa None None None None None 5d72 H L 0 A protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 08/13/15 Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M. 2.6 X-RAY DIFFRACTION 0.266 0.232 False True IGHV3 IGLV3 Lambda 6e-12 -15.309340828919966 Unknown TBD 3ck0 H L 0 P peptide protein (8-mer; human angiotensin ii) IMMUNE SYSTEM 06/14/99 ANTI-ANTI-IDIOTYPIC ANTIBODY AGAINST HUMAN ANGIOTENSIN II, COMPLEX WITH HUMAN ANGIOTENSIN II MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Pan, Y.H., Amzel, L.M. 3.0 X-RAY DIFFRACTION unknown 0.200 False False IGHV10 IGKV8 Kappa None None None None None 6w7y H L 0 IMMUNE SYSTEM 03/19/20 Crystal structure of SARS-CoV and SARS-CoV-2 reactive human antibody CR3022 HOMO SAPIENS homo sapiens homo sapiens Chen, W.H., Joyce, M.G. 3.3 X-RAY DIFFRACTION 0.278 0.252 False True IGHV5 IGKV4 Kappa None None None None None 6c5v H L 0 A | C | B protein | protein | protein NA | NA | NA envelope glycoprotein h | glycoprotein 42 | envelope glycoprotein l VIRAL PROTEIN 01/16/18 An anti-gH/gL antibody that neutralizes dual-tropic infection defines a site of vulnerability on Epstein-Barr virus HUMAN HERPESVIRUS 4; HOMO SAPIENS homo sapiens homo sapiens human herpesvirus 4 | human herpesvirus 4 | human herpesvirus 4 Snijder, J., Ortego, M.S., Weidle, C., Stuart, A.B., Gray, M.A., McElrath, M.J., Pancera, M., Veesler, D., McGuire, A.T., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 4.8 ELECTRON MICROSCOPY False True IGHV1 IGLV3 Lambda None None None None None 1j1p H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 12/13/02 Crystal structure of HyHEL-10 Fv mutant LS91A complexed with hen egg white lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Yokota, A., Tsumoto, K., Shiroishi, M., Kondo, H., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.212 0.191 False True IGHV3 IGKV5 Kappa None None None None None 5utf H L 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/14/17 Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Chuang, G.-Y., Xu, K., Kwong, P.D. 3.503 X-RAY DIFFRACTION 0.299 0.216 False True IGHV4 IGLV3 Lambda None None None None None 7kml H L 0 A protein NA spike glycoprotein Viral protein/Immune System 11/03/20 cryo-EM structure of SARS-CoV-2 spike in complex with Fab 15033-7, three RBDs bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7x6l G J 0 E | A protein | protein NA | NA hemagglutinin | hemagglutinin STRUCTURAL PROTEIN 03/07/22 Cryo-EM structure of H3 hemagglutinin from A/HongKong/01/1968 in complex with a neutralizing antibody 28-12 HOMO SAPIENS; INFLUENZA A VIRUS (A/HONG KONG/1/1968(H3N2)); INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus (a/hong kong/1/1968(h3n2)) Cong, Y., Liu, C.X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5bv7 H L 0 A protein phosphatidylcholine-sterol acyltransferase HYDROLASE/IMMUNE SYSTEM 06/04/15 Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Piper, D.E., Romanow, W.G., Thibault, S.T., Walker, N.P.C. 2.45 X-RAY DIFFRACTION 0.242 0.189 False False IGHV4 IGLV3 Lambda None None None None None 5mhr I H 0 B protein NA viral attachment protein sigma 1 IMMUNE SYSTEM 11/25/16 T3D reovirus sigma1 complexed with 9BG5 Fab fragments REOVIRUS SP.; MUS MUSCULUS mus musculus mus musculus reovirus sp. Stehle, T., Dietrich, M.H. 3.0 X-RAY DIFFRACTION 0.247 0.212 False False IGHV1 IGKV4 Kappa None None None None None 2kh2 B b 9 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6u0l H L 0 A protein envelope glycoprotein gp160 VIRAL PROTEIN 08/14/19 Asymmetrically open conformational state (Class I) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 4s2s H L 0 IMMUNE SYSTEM 01/22/15 Crystal Structure of Fab fragment of monoclonal antibody RoAb13 MUS MUSCULUS mus musculus mus musculus Chain, B., Arnold, J., Akthar, S., Noursadeghi, M., Lapp, T., Ji, C., Naider, D., Zhang, Y., Govada, L., Saridakis, E., Chayen, N.E. 2.1 X-RAY DIFFRACTION 0.234 0.186 False False IGHV5 IGKV8 Kappa None None None None None 7rg9 E e 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/14/21 cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA mus musculus homo sapiens | homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6fzr H h 0 P peptide mucin-1 IMMUNE SYSTEM 03/15/18 Crystal structure of scFv-SM3 in complex with compound 2 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Bermejo, I.A., Usabiaga, I., Companon, I., Castro-Lopez, J., Insausti, A., Fernandez, J.A., Avenoza, A., Busto, J.H., Jimenez-Barbero, J., Asensio, J.L., Jimenez-Oses, G., Peregrina, J.M., Hurtado-Guerrero, R., Cocinero, E.J., Corzana, F. 1.8 X-RAY DIFFRACTION 0.232 0.187 True True unknown unknown unknown None None None None None 5w5z H L 0 A protein apoptosis regulator bax APOPTOSIS 06/16/17 Crystal structure of BAXP168G in complex with an activating antibody at high resolution HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Robin, A.Y., Colman, P.M., Czabotar, P.E. 1.997 X-RAY DIFFRACTION 0.268 0.217 False False IGHV1 IGKV22 Kappa None None None None None 6i1o H L 0 PROTEIN BINDING 10/29/18 Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin MUS MUSCULUS mus musculus mus musculus Laffranchi, M., Elliston, E.L.K., Miranda, E., Perez, J., Fra, A., Lomas, D.A., Irving, J.A. 1.93 X-RAY DIFFRACTION 0.235 0.199 False False IGHV5 IGKV14 Kappa None None None None None 5nhr H L 0 C protein activin receptor type-2b IMMUNE SYSTEM 03/22/17 CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM HOMO SAPIENS homo sapiens homo sapiens homo sapiens RONDEAU, J.-M. 3.35 X-RAY DIFFRACTION 0.229 0.216 False True IGHV1 IGLV2 Lambda None None None None None 7mfb H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4 Fab - light chain H31F variant HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 1.74 X-RAY DIFFRACTION 0.246 0.223 False True IGHV3 IGLV3 Lambda None None None None None 3chn C O 7 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 1q9k B A 0 IMMUNE SYSTEM 08/25/03 S25-2 Fab Unliganded 1 MUS MUSCULUS mus musculus mus musculus Nguyen, H.P., Seto, N.O., MacKenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.96 X-RAY DIFFRACTION 0.278 0.228 False False IGHV7 IGKV8 Kappa None None None None None 5e8e B A 0 H protein thrombin heavy chain IMMUNE SYSTEM/HYDROLASE 10/14/15 Crystal structure of thrombin bound to an exosite 1-specific IgA Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Baglin, T.P., Langdown, J., Frasson, R., Huntington, J.A. 1.9 X-RAY DIFFRACTION 0.244 0.201 False False IGHV1 IGKV3 Kappa 1.8000000000000002e-09 -11.929942798416155 SPR TBD 6gkd C NA 0 A protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 7chh D E 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with BD-368-2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J., Zhu, Q., Wang, G. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 6dc4 H L 0 IMMUNE SYSTEM 05/04/18 RSV-neutralizing human antibody AM22 HOMO SAPIENS homo sapiens homo sapiens Jones, H.G., McLellan, J.S. 1.7 X-RAY DIFFRACTION 0.205 0.180 False True IGHV1 IGKV3 Kappa None None None None None 6nmr H L 0 S protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.42 X-RAY DIFFRACTION 0.323 0.289 False True IGHV3 IGKV3 Kappa None None None None None 4ubd O P 0 N | Q protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain viral protein/immune system 08/12/14 Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Shore, D.A., Yang, H., Cho, M., Donis, R.O., Stevens, J. 3.5 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 IGKV3 Kappa None None None None None 6w73 H L 0 NA NA NA NA IMMUNE SYSTEM 03/18/20 Fab Structure of CD4 Binding Site (CD4bs) Huamn Monoclonal Antibody HmAb64 HOMO SAPIENS homo sapiens homo sapiens Kong, X., Pan, R. 2.8 X-RAY DIFFRACTION 0.263 0.178 False True IGHV1 IGKV1 Kappa None None None None None 1v7n H L 0 V protein thrombopoietin IMMUNE SYSTEM/CYTOKINE 12/18/03 Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R. 3.3 X-RAY DIFFRACTION 0.305 0.167 False True IGHV6 IGKV4 Kappa None None None None None 6k7o B C 0 P protein NA leukocyte immunoglobulin-like receptor subfamily b member4 IMMUNE SYSTEM 06/08/19 Complex structure of LILRB4 and h128-3 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Song, H., Chai, Y., Xu, X., Gao, F.G. 3.004 X-RAY DIFFRACTION 0.270 0.228 False True IGHV3 IGKV1 Kappa None None None None None 4nrx H L 0 P peptide envelope glycoprotein gp41 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66 in complex with gp41 MPER peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Yang, Y., Kwong, P.D. 2.21 X-RAY DIFFRACTION 0.215 0.188 False True IGHV5 IGKV1 Kappa None None None None None 4rrp K E 0 Q protein antigen asf1p IMMUNE SYSTEM 11/06/14 Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Kuzin, A., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Oconnell, P.T., Maglaqui, M., Bailey, L., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG) 2.79 X-RAY DIFFRACTION 0.253 0.183 False True IGHV3 IGKV1 Kappa None None None None None 1tzh B A 0 W protein vascular endothelial growth factor a immune system 07/09/04 Crystal Structure of the Fab YADS1 Complexed with h-VEGF HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Fellouse, F.A., Wiesmann, C., Sidhu, S.S. 2.6 X-RAY DIFFRACTION 0.271 0.212 False True IGHV5 IGKV12 Kappa 1.80E-09 -12.4 SPR 37 15306681 3aaz A B 0 IMMUNE SYSTEM 11/28/09 Crystal structure of the humanized recombinant Fab fragment of a murine; antibody HOMO SAPIENS homo sapiens homo sapiens Streltsov, V.A. 2.2 X-RAY DIFFRACTION 0.271 0.209 False True IGHV2 IGKV2 Kappa None None None None None 6ukt D NA 0 A protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 10/05/19 Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., Zhang, K., Johnston, J.D., Chiu, W., Sprang, S.R. 3.87 ELECTRON MICROSCOPY False True IGHV1 None None None None None 3cm9 C N 5 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7sn3 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/21 Structure of human SARS-CoV-2 spike glycoprotein trimer bound by neutralizing antibody C1C-A3 Fab (variable region) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Shankar, S. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7x7e E NA 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/09/22 SARS-CoV-2 RBD and Nb22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA lama severe acute respiratory syndrome coronavirus2 Wang, Y., Ye, S. 2.67 X-RAY DIFFRACTION 0.250 0.205 False True IGHV1 NA NA None None None None None 5j13 C B 0 A protein thymic stromal lymphopoietin IMMUNE SYSTEM 03/28/16 Cytokine antibody complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Verstraete, K., Savvides, S.N. 2.298 X-RAY DIFFRACTION 0.215 0.189 False True IGHV3 IGLV3 Lambda 6e-11 -13.945096739509712 SPR TBD 7lua h g 0 M carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS; HOMO SAPIENS homo sapiens homo sapiens Manne, K., Edwards, R.J., Acharya, P. 4.7 ELECTRON MICROSCOPY NA NA False False unknown IGKV2 Kappa None None None None None 5kov O o 0 M protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 2ykl H L 0 H Hapten NLD NICOTINE-11-YL-METHYL-(4-ETHYLAMINO-4-OXO)-BUTANOATE IMMUNE SYSTEM 05/27/11 Structure of human anti-nicotine Fab fragment in complex with nicotine-11-yl-methyl-(4-ethylamino-4-oxo)-butanoate HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tars, K., Kotelovica, S., Lipowsky, G., Bauer, M., Beerli, R., Bachmann, M., Maurer, P. 2.1 X-RAY DIFFRACTION 0.27404 0.21352 False True IGHV4 IGLV1 Lambda None None None None None 7anq B NA 0 A protein NA proprotein convertase subtilisin/kexin type 9 HYDROLASE 10/12/20 Complete PCSK9 C-ter domain in complex with VHH P1.40 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Ciccone, L., Legrand, P., Stura, E.A., Dive, V., Seidahn, N.G., Fruchart Gaillard, C. 2.2 X-RAY DIFFRACTION 0.256 0.213 False True IGHV1 NA NA None None None None None 5n7w H L 0 X protein interleukin-17a IMMUNE SYSTEM 02/21/17 Computationally designed functional antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hargreaves, D., Breed, J. 1.96 X-RAY DIFFRACTION 0.250 0.199 False True IGHV1 IGKV1 Kappa 8e-08 -9.681917538322692 SPR TBD 7rtp NA B 0 B Hapten NY9 N-{2-[7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl]ethyl}-N'-[(pyridin-3-yl)methyl]urea IMMUNE SYSTEM 08/13/21 Structure of full-length human lambda-6A light chain JTO in complex with urea stabilizer 20 [1-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-3-(pyridin-3-ylmethyl)urea] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.09 X-RAY DIFFRACTION 0.238 0.179 False True NA IGLV6 Lambda None None None None None 6zbp F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 06/08/20 H11-H4 complex with SARS-CoV-2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Huo, J., Mikolajek, H., Ward, P., Dumoux, M., Owens, R.J., LeBas, A. 1.85 X-RAY DIFFRACTION 0.217 0.185 False False IGHV1 NA NA None None None None None 6nc3 O T 0 I | C protein | protein NA | NA hiv-1 env amc011 v4.2 sosip gp41 | hiv-1 env amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Torres, J.L., Ward, A.B. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 4x7f C NA 0 A protein capsid protein VIRAL PROTEIN 12/09/14 Crystal structure of norovirus GII.10 P domain in complex with Nano-25 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, G.S. 1.7 X-RAY DIFFRACTION 0.187 0.160 False True IGHV1 2.8000000000000003e-08 -10.303920013991087 ITC TBD 3qxw D NA 0 IMMUNE SYSTEM 03/02/11 Free structure of an anti-methotrexate CDR1-4 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.85 X-RAY DIFFRACTION 0.238 0.189 False True IGHV1 None None None None None 7qn9 M NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state HOMO SAPIENS homo sapiens homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2kqm NA A 15 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1kfa I M 0 I Hapten GA4 GIBBERELLIN A4 IMMUNE SYSTEM 11/20/01 Crystal structure of Fab fragment complexed with gibberellin A4 MUS MUSCULUS mus musculus mus musculus mus musculus Murata, T., Fushinobu, S., Nakajima, M., Asami, O., Sassa, T., Wakagi, T., Yamaguchi, I. 2.8 X-RAY DIFFRACTION 0.313 0.235 False True IGHV5 IGKV1 Kappa None None None None None 7dfb H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | v2rpp-6-7 SIGNALING PROTEIN 11/06/20 Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex BOS TAURUS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | synthetic construct Sun, J.P., Yu, X., Xiao, P., He, Q.T., Lin, J.Y., Zhu, Z.L. 3.28 X-RAY DIFFRACTION 0.291 0.231 False True IGHV3 IGKV1 Kappa None None None None None 6mhg M W 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6u0l P Q 0 C protein envelope glycoprotein gp160 VIRAL PROTEIN 08/14/19 Asymmetrically open conformational state (Class I) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 3.3 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 7sd5 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/29/21 Crystallographic structure of neutralizing antibody 10-40 in complex with SARS-CoV-2 spike receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Casner, R.G., Shapiro, L. 1.53 X-RAY DIFFRACTION 0.206 0.176 False True IGHV4 IGLV6 Lambda None None None None None 1for H L 0 IMMUNOGLOBULIN 05/24/94 STRUCTURE DETERMINATION OF AN FAB FRAGMENT THAT NEUTRALIZES HUMAN RHINOVIRUS AND ANALYSIS OF THE FAB-VIRUS COMPLEX MUS MUSCULUS mus musculus mus musculus Smith, T.J., Liu, H. 2.75 X-RAY DIFFRACTION unknown 0.174 False True IGHV1 IGKV4 Kappa None None None None None 2dqh H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/26/06 Crystal structure of hyhel-10 FV mutant (Hy58a) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 2.3 X-RAY DIFFRACTION 0.264 0.207 False True IGHV3 IGKV5 Kappa None None None None None 3uzv B b 0 A protein envelope protein IMMUNE SYSTEM 12/07/11 Crystal structure of the dengue virus serotype 2 envelope protein domain III in complex with the variable domains of Mab 4E11 DENGUE VIRUS 2; MUS MUSCULUS mus musculus dengue virus 2 Cockburn, J.J.B., Navarro Sanchez, M.E., Fretes, N., Urvoas, A., Staropoli, I., Kikuti, C.M., Coffey, L.L., Arenzana Seisdedos, F., Bedouelle, H., Rey, F.A. 2.1 X-RAY DIFFRACTION 0.214 0.206 True True unknown unknown unknown 4.3e-10 -12.77823529775025 ELISA TBD 7jjo N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/27/20 Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound Beta1-Adrenergic Receptor BOS TAURUS; LAMA GLAMA; MELEAGRIS GALLOPAVO lama glama bos taurus | bos taurus Su, M., Zhu, L., Zhang, Y., Paknejad, N., Dey, R., Huang, J., Lee, M.Y., Williams, D., Jordan, K.D., Eng, E.T., Ernst, O.P., Meyerson, J.R., Hite, R.K., Walz, T., Liu, W., Huang, X.Y. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6mft H L 0 G protein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 09/12/18 Crystal structure of glycosylated 426c HIV-1 gp120 core G459C in complex with glVRC01 A60C heavy chain HOMO SAPIENS homo sapiens homo sapiens homo sapiens Weidle, C., Pancera, M., Stamatatos, L., Gray, M. 2.315 X-RAY DIFFRACTION 0.295 0.244 False True IGHV1 IGKV3 Kappa 2.2999999999999996e-06 -7.691979474199363 SPR TBD 2g75 C D 0 IMMUNE SYSTEM 02/27/06 Crystal Structure of anti-SARS m396 Antibody HOMO SAPIENS homo sapiens homo sapiens Prabakaran, P., Gan, J.H., Feng, Y., Zhu, Z.Y., Xiao, X.D., Ji, X., Dimitrov, D.S. 2.28 X-RAY DIFFRACTION 0.277 0.221 False True IGHV1 IGLV3 Lambda None None None None None 6nc3 P U 0 J | D protein | protein NA | NA hiv-1 env amc011 v4.2 sosip gp41 | hiv-1 env amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Torres, J.L., Ward, A.B. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6z3k A B 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 5mu2 G H 0 S peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 7jvq N NA 0 A | B | G protein | protein | protein NA | NA | NA engineered mini-gi protein alpha sub-unit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 SIGNALING PROTEIN 08/22/20 Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens | homo sapiens Zhuang, Y., Xu, P., Mao, C., Wang, L., Krumm, B., Zhou, X.E., Huang, S., Liu, H., Cheng, X., Huang, X.-P., Sheng, D.-D., Xu, T., Liu, Y.-F., Wang, Y., Guo, J., Jiang, Y., Jiang, H., Melcher, K., Roth, B.L., Zhang, Y., Zhang, C., Xu, H.E. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7kqy A NA 0 NA NA NA NA IMMUNE SYSTEM 11/18/20 Crystal Structure and Characterization of Human Heavy-Chain only Antibodies reveals a novel, stable dimeric structure similar to Monoclonal Antibodies HOMO SAPIENS homo sapiens Bahmanjah, S., Mieczkowski, C., Yu, Y., Baker, J., Raghunathan, G., Tomazela, D., Hsieh, M., Mccoy, M., Strickland, C., Fayadat-Dilman, L. 2.913 X-RAY DIFFRACTION 0.260 0.207 False True IGHV1 NA NA None None None None None 7k8t M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Malyutin, A.G., Barnes, C.O., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7beo A B 0 R protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253H55L and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 3.19 X-RAY DIFFRACTION 0.274 0.234 False True IGHV3 IGKV1 Kappa None None None None None 7l2e I K 0 C protein NA spike glycoprotein Viral Protein/IMMUNE SYSTEM 12/16/20 Cryo-EM structure of NTD-directed neutralizing antibody 4-18 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 4hs6 B A 0 Z peptide e2-peptide IMMUNE SYSTEM 10/29/12 Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody MRCT10.v362 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Eigenbrot, C., Ultsch, M. 1.53 X-RAY DIFFRACTION 0.200 0.175 False True IGHV4 IGKV1 Kappa 3.0000000000000004e-08 -10.26304286359873 Unknown TBD 3rhw G K 0 C protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.26 X-RAY DIFFRACTION 0.270 0.239 False True IGHV1 IGLV1 Lambda None None None None None 7kkl F NA 0 D protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/20 SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 2.85 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5wb1 A NA 0 MEMBRANE PROTEIN 06/27/17 Ligand-free US28 with stabilizing intracellular nanobody HUMAN CYTOMEGALOVIRUS; LAMA GLAMA human cytomegalovirus, lama glama Jude, K.M., Burg, J.S., Garcia, K.C. 3.508 X-RAY DIFFRACTION 0.289 0.242 False True IGHV1 None None None None None 1vhp A NA 6 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4kjp C D 0 A protein h(+)/cl(-) exchange transporter clca tranport protein, membrane protein 05/03/13 Structure of the CLC-ec1 deltaNC construct in the absence of halide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C 3.2 X-RAY DIFFRACTION 0.265 0.222 False True IGHV4 IGKV4 Kappa None None None None None 5t1k B A 0 IMMUNE SYSTEM 08/19/16 Cetuximab Fab in complex with CQFDA(Ph)2STRRLKC MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.213 0.160 False True IGHV2 IGKV5 Kappa 5.3e-07 -8.561619551666432 Unknown TBD 6ikm A a 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 7lbg F E 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 01/07/21 CryoEM structure of the HCMV Trimer gHgLgO in complex with human Transforming growth factor beta receptor type 3 and neutralizing fabs 13H11 and MSL-109 HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN); HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus (strain merlin) Kschonsak, M., Rouge, L., Arthur, C.P., Hoangdung, H., Patel, N., Kim, I., Johnson, M., Kraft, E., Rohou, A.L., Gill, A., Martinez-Martin, N., Payandeh, J., Ciferri, C. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3qpq J I 0 IMMUNE SYSTEM 02/14/11 Crystal structure of ANTI-TLR3 antibody C1068 FAB HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Luo, J., Obmolova, G., Teplyakov, A., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.256 0.201 False True IGHV1 IGKV12 Kappa None None None None None 4odu A B 0 IMMUNE SYSTEM 01/10/14 Unliganded Fab structure of lipid A-specific antibody S1-15 MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.29 X-RAY DIFFRACTION 0.233 0.187 False False IGHV10 IGKV10 Kappa None None None None None 4j1u B A 0 IMMUNE SYSTEM 02/02/13 Crystal structure of antibody 93F3 unstable variant MUS MUSCULUS mus musculus mus musculus Wang, F. 2.58 X-RAY DIFFRACTION 0.276 0.210 False True IGHV2 IGKV8 Kappa None None None None None 7oap A NA 0 E protein NA unknown ANTIVIRAL PROTEIN 04/19/21 Nanobody H3 AND C1 bound to RBD LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 Naismith, J.H., Mikolajek, H. 1.901 X-RAY DIFFRACTION 0.204 0.180 False False IGHV1 NA NA None None None None None 2r1x B A 0 B carbohydrate KDA (3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID)-2-O-ALLYL IMMUNE SYSTEM 08/23/07 Crystal structure of S25-2 Fab in complex with Kdo analogues MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 1.6 X-RAY DIFFRACTION 0.239 0.217 False False IGHV7 IGKV8 Kappa 1.6e-05 -6.5427509671824025 Unknown TBD 7l79 A B 0 NA NA NA NA IMMUNE SYSTEM 12/27/20 Crystal structure of broadly HIV-1-neutralizing antibody VRC40.01 HOMO SAPIENS homo sapiens homo sapiens Zhou, T., Kwong, P.D. 2.826 X-RAY DIFFRACTION 0.280 0.220 False True unknown unknown unknown None None None None None 4hix H L 0 A peptide beta-amyloid protein 40 PROTEIN FIBRIL/Immune System 10/12/12 Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide HOMO SAPIENS, MUS MUSCULUS; SYNTHETIC CONSTRUCT homo sapiens, mus musculus homo sapiens, mus musculus homo sapiens Miles, L.A., Crespi, G.A.N., Parker, M.W. 2.204 X-RAY DIFFRACTION 0.220 0.170 False True IGHV3 IGKV2 Kappa 1.5100000000000002e-07 -9.305540383386383 Unknown TBD 2ltq F E 4 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 3whe Y Z 0 G protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 7m7e C D 0 A | B protein | protein NA | NA 6-deoxyerythronolide-b synthase erya2, modules 3 and 4,eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 chimera | 6-deoxyerythronolide-b synthase erya2, modules 3 and 4,eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and 6 chimera BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea | saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7eo0 H L 0 3 protein NA o/tibet/99 vp3 VIRUS 04/21/21 FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY C4 BOS TAURUS; FOOT-AND-MOUTH DISEASE VIRUS bos taurus bos taurus foot-and-mouth disease virus He, Y., Li, K. 3.75 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6u8c H L 0 IMMUNE SYSTEM 09/04/19 Crystal structure of an engineered ultra-high affinity Fab-Protein G complex STREPTOCOCCUS SP. 'GROUP G'; HOMO SAPIENS homo sapiens homo sapiens Slezak, T., Filippova, E.V., Davydova, E.K., Kossiakoff, A.A. 2.61 X-RAY DIFFRACTION 0.250 0.192 False True IGHV3 IGKV1 Kappa None None None None None 1oau NA O 0 IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 1.8 X-RAY DIFFRACTION 0.264 0.226 False True IGLV1 Lambda 2.00e-08 Other 20 12610298 1yeh H L 0 CATALYTIC ANTIBODY 05/29/97 STRUCTURE OF IGG2A FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus Gigant, B., Knossow, M. 2.55 X-RAY DIFFRACTION 0.231 0.181 False False IGHV1 IGKV1 Kappa None None None None None 2b1a H L 0 P peptide ug1033 peptide of exterior membrane glycoprotein gp120 IMMMUNE SYSTEM 09/15/05 Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG1033 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Stanfield, R.L., Gorny, M.K., Zolla-Pazner, S., Wilson, I.A. 2.348 X-RAY DIFFRACTION 0.244 0.211 False False IGHV5 IGLV1 Lambda None None None None None 6fxn M N 0 J protein tumor necrosis factor ligand superfamily member 13b IMMUNE SYSTEM 03/09/18 Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lammens, A., Maskos, K., Willen, L., Jiang, X., Schneider, P. 2.9 X-RAY DIFFRACTION 0.231 0.191 False True IGHV1 IGLV3 Lambda None None None None None 4lqf H L 0 A protein a33r IMMUNE SYSTEM 07/17/13 Structure of murine IgG2b A2C7-Fab in complex with vaccinia antigen A33R at the resolution of 2.3 Angstroms MUS MUSCULUS; VACCINIA VIRUS mus musculus mus musculus vaccinia virus Matho, M.H., Schlossman, A.M., Zajonc, D.M. 2.3 X-RAY DIFFRACTION 0.230 0.197 False True IGHV5 IGKV1 Kappa 6.45e-11 -13.902247927796981 SPR TBD 6pa0 A B 0 C protein ph-gated potassium channel kcsa protein transport/immune system 06/11/19 Structure of the G77A mutant in Sodium Chloride STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Guan, L. 2.05 X-RAY DIFFRACTION 0.233 0.196 False False IGHV1 IGKV5 Kappa None None None None None 6chb Q R 0 H protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 6.801 X-RAY DIFFRACTION 0.417 0.318 False True unknown IGLV3 Lambda None None None None None 4qnp H L 0 B protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 06/18/14 Crystal structure of the 2009 pandemic H1N1 influenza virus neuraminidase with a neutralizing antibody INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Wan, H.Q., Yang, H., Shore, D.A., Garten, R.J., Couzens, L., Gao, J., Jiang, L.L., Carney, P.J., Villanueva, J., Stevens, J., Eichelberger, M.C. 2.8 X-RAY DIFFRACTION 0.224 0.181 False True IGHV10 IGKV4 Kappa None None None None None 7qbe F NA 0 C protein NA transcobalamin-2 TRANSPORT PROTEIN 11/19/21 TC:CD320 in complex with nanobody TC-Nb11 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Bloch, J.S., Locher, K.P. 3.0 X-RAY DIFFRACTION 0.284 0.252 False True IGHV1 NA NA None None None None None 1rup H L 0 immune system 12/11/03 Crystal structure (G) of native cationic cyclization antibody 4C6 fab at pH 8.5 with a data set collected at APS beamline 19-ID MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 1.4 X-RAY DIFFRACTION unknown unknown False False IGHV3 IGKV1 Kappa None None None None None 6pe8 A B 0 U protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 06/20/19 Crystal structure of CD40/ABBV-323 FAB complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Argiriadi, M.A. 2.84 X-RAY DIFFRACTION 0.265 0.205 False True IGHV3 IGKV4 Kappa None None None None None 6ev2 G H 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan in complex with laminarihexaose MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Duebel, S., Blankenfeldt, W., Rau, U. 2.403 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV4 Kappa None None None None None 5xbm E D 0 F protein lysosome membrane protein 2 IMMUNE SYSTEM/PROTEIN BINDING 03/20/17 Structure of SCARB2-JL2 complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhang, X., Yang, P., Wang, N., Zhang, J., Li, J., Guo, H., Yin, X., Rao, Z., Wang, X., Zhang, L. 3.501 X-RAY DIFFRACTION 0.293 0.238 False False IGHV1 IGKV5 Kappa None None None None None 7m1h C NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/13/21 Crystal structure of LC/A-JPU-C10-JPU-D12-JPU-B8-JPU-G3-ciA-F12-ciA-D12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.78 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 NA NA None None None None None 1kcu H L 0 IMMUNE SYSTEM 11/11/01 CRYSTAL STRUCTURE OF ANTIBODY PC287 MUS MUSCULUS mus musculus mus musculus Nair, D.T., Singh, K., Siddiqui, Z., Nayak, B.P., Rao, K.V.S., Salunke, D.M. 2.2 X-RAY DIFFRACTION 0.249 0.200 False False IGHV3 IGKV6 Kappa None None None None None 4tnv X i 0 S protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False unknown unknown unknown None None None None None 2mmx NA A 6 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 4xcy A B 0 A Hapten 44G (2S)-3-{[(R)-{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidylglycerol (06:0 PG) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 3.96 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 IGKV3 Kappa None None None None None 6z20 D NA 0 C protein NA cd9 antigen CELL ADHESION 05/14/20 Structure of the EC2 domain of CD9 in complex with nanobody 4C8 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Oosterheert, W., Manshande, J., Pearce, N.M., Lutz, M., Gros, P. 2.68 X-RAY DIFFRACTION 0.248 0.206 False True IGHV1 NA NA None None None None None 6njl N M 0 B protein glutamate receptor 2 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.7 ELECTRON MICROSCOPY False True IGHV2 IGKV10 Kappa None None None None None 2mkw NA A 9 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6b0s H L 0 C protein circumsporozoite protein IMMUNE SYSTEM 09/15/17 Crystal structure of circumsporozoite protein aTSR domain in complex with 1710 antibody HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Murugan, R., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 1.95 X-RAY DIFFRACTION 0.224 0.180 False True IGHV3 IGLV3 Lambda 1.78e-07 -9.20807461785177 SPR TBD 6utk H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/19 Crystal structure of 438-B11 Fab in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 at 3.80 Angstrom HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 3.8 X-RAY DIFFRACTION 0.317 0.299 False True unknown IGKV3 Kappa None None None None None 7bb7 G NA 0 E | C | F protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 12/17/20 AVP-V2R-Galphas-beta1-gamma2-Nb35(T state) HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Bous, J., Mouillac, B., Bron, P., Granier, S. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3u6r A B 0 IMMUNE SYSTEM 10/12/11 Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 single chain FV fragment 1:7 HOMO SAPIENS homo sapiens homo sapiens Gilmartin, A.A., Lamp, B., Ruemenapf, T., Persson, A.A., Rey, F.A., Krey, T. 2.67 X-RAY DIFFRACTION 0.232 0.190 False True IGHV1 IGKV3 Kappa None None None None None 6w51 Q R 0 NA NA NA NA IMMUNE SYSTEM 03/12/20 Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Wright, K.M., Gabelli, S.B. 3.53 X-RAY DIFFRACTION 0.283 0.200 False True IGHV3 IGKV1 Kappa None None None None None 3bsz N M 0 E protein plasma retinol-binding protein TRANSPORT PROTEIN/IMMUNE SYSTEM 12/27/07 Crystal structure of the transthyretin-retinol binding protein-Fab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zanotti, G., Cendron, L., Gliubich, F., Folli, C., Berni, R. 3.38 X-RAY DIFFRACTION 0.312 0.239 False True IGHV1 IGKV3 Kappa None None None None None 5fgb C A 0 F peptide genome polyprotein IMMUNE SYSTEM 12/20/15 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.4 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus genotype 1a (isolate h) Girard-Blanc, C., Rey, F.A., Krey, T. 1.65 X-RAY DIFFRACTION 0.190 0.171 False True IGHV3 IGLV3 Lambda None None None None None 5w1k Q M 0 R protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV4 IGKV3 Kappa None None None None None 7nfq D NA 0 B protein NA polymerase basic protein 2 VIRAL PROTEIN 02/07/21 Fujian capmidlink domain in complex with Nb8193 INFLUENZA A VIRUS (A/DUCK/FUJIAN/13/2002(H5N1)); CAMELIDAE MIXED LIBRARY camelidae mixed library influenza a virus (a/duck/fujian/13/2002(h5n1)) Keown, J.R., Grimes, J.M., Fodor, E. 1.68 X-RAY DIFFRACTION 0.205 0.167 False True IGHV3 NA NA None None None None None 5wdu M N 0 J protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True unknown unknown unknown None None None None None 6x1t A B 0 N peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 2.34 X-RAY DIFFRACTION 0.269 0.244 False True IGHV1 IGKV1 Kappa None None None None None 7t0k B A 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 4 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.0 X-RAY DIFFRACTION 0.255 0.222 False True IGHV7 IGKV8 Kappa None None None None None 7kn5 E NA 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobodies VHH E and U SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 1.87 X-RAY DIFFRACTION 0.213 0.177 False True IGHV1 NA NA None None None None None 6mu8 D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/22/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-386150 in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.993 X-RAY DIFFRACTION 0.259 0.219 False True unknown unknown unknown None None None None None 4hfw H L 0 IMMUNE SYSTEM 10/05/12 Anti Rotavirus Antibody HOMO SAPIENS homo sapiens homo sapiens Spiller, B.W., Aiyegbo, M., Crowe, J.E. 2.601 X-RAY DIFFRACTION 0.233 0.186 False True IGHV1 IGKV1 Kappa None None None None None 4kmt H L 0 IMMUNE SYSTEM 05/08/13 Crystal structure of human germline antibody 5-51/O12 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.1 X-RAY DIFFRACTION 0.220 0.171 False True IGHV5 IGKV1 Kappa None None None None None 6iea H L 0 A protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R13 RIFT VALLEY FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 2.0 X-RAY DIFFRACTION 0.225 0.181 False True IGHV4 IGLV5 Lambda None None None None None 6d9g C D 0 IMMUNE SYSTEM 04/29/18 X-ray Structure of the FAB Fragment of 15B8, a Murine Monoclonal Antibody Specific for the Human Serotonin Transporter MUS MUSCULUS mus musculus mus musculus Coleman, J.A., Yang, D., Gouaux, E. 2.3 X-RAY DIFFRACTION 0.228 0.195 False True IGHV1 IGKV3 Kappa None None None None None 6ppg B A 0 G protein interleukin-17f CYTOKINE 07/06/19 Crystal structure of IL17FF bound to Fab fragments of MCAF5352A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Huang, C.S., Yin, J.P., Hymowitz, S.G. 2.75 X-RAY DIFFRACTION 0.275 0.224 False True IGHV3 IGKV3 Kappa None None None None None 6vn1 I M 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/29/20 A 2.8 Angstrom Cryo-EM Structure of a Glycoprotein B-Neutralizing Antibody Complex Reveals a Critical Domain for Herpesvirus Fusion Initiation HOMO SAPIENS; HUMAN ALPHAHERPESVIRUS 3 homo sapiens homo sapiens human alphaherpesvirus 3 Oliver, S.L. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 4pb0 H L 0 IMMUNE SYSTEM 04/10/14 Structure of the Fab fragment of the anti-Francisella tularensis GroEL antibody Ab53 MUS MUSCULUS mus musculus mus musculus Lu, Z., Rynkiewicz, M.J., Seaton, B.A., Sharon, J. 2.5 X-RAY DIFFRACTION 0.252 0.210 False False IGHV6 IGKV1 Kappa None None None None None 4nhg E G 0 IMMUNE SYSTEM 11/05/13 Crystal Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West, Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 8.001 X-RAY DIFFRACTION 0.369 0.359 False True unknown IGKV1 Kappa None None None None None 7lcn M S 0 K protein NA spike glycoprotein IMMUNE SYSTEM 01/11/21 Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1050.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 3.35 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 1oak H L 0 A protein von willebrand factor COMPLEX (WILLEBRAND/IMMUNOGLOBULIN) 12/18/97 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH THE FUNCTION BLOCKING NMC-4 FAB MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Celikel, R., Varughese, K.I. 2.2 X-RAY DIFFRACTION 0.274 0.201 False True IGHV2 IGKV10 Kappa None None None None None 1p4i H L 0 IMMUNE SYSTEM 04/23/03 Crystal Structure of scFv against peptide GCN4 MUS MUSCULUS mus musculus mus musculus Zahnd, C., Spinelli, S., Luginbuhl, B., Jermutus, L., Amstutz, P., Cambillau, C., Pluckthun, A. 2.8 X-RAY DIFFRACTION 0.260 0.200 True True IGHV2 IGLV1 Lambda None None None None None 4lou E F 0 B protein h(+)/cl(-) exchange transporter clca membrane protein, tranport protein 07/13/13 Structure of the E148Q mutant of CLC-ec1 deltaNC construct in the absence of halide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.981 X-RAY DIFFRACTION 0.253 0.210 False True IGHV4 IGKV4 Kappa None None None None None 6k68 J K 0 L protein protein a STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (8420-3MNZ) HUMAN IMMUNODEFICIENCY VIRUS 1; STAPHYLOCOCCUS AUREUS human immunodeficiency virus 1 human immunodeficiency virus 1 staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 3.2 X-RAY DIFFRACTION 0.318 0.289 False True IGHV9 IGKV8 Kappa None None None None None 1maj NA A 1 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 1v7m I M 0 X protein thrombopoietin IMMUNE SYSTEM/CYTOKINE 12/18/03 Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R. 2.51 X-RAY DIFFRACTION 0.316 0.228 False True IGHV6 IGKV4 Kappa None None None None None 6vuo A a 0 NA NA NA NA PROTEIN BINDING 02/16/20 Reverse Transcriptase Diabody with S82bC/R83T Mutation HOMO SAPIENS homo sapiens Chelsy, C., Arnold, E. 1.449 X-RAY DIFFRACTION 0.172 0.141 True True unknown unknown unknown None None None None None 3nig H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION/BLOOD CLOTTING 06/15/10 The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.25 X-RAY DIFFRACTION 0.212 0.172 False True IGHV14 IGKV14 Kappa None None None None None 5opy H L 0 NA NA NA NA IMMUNE SYSTEM 08/10/17 Crystal structure of anti-alphaVbeta3 integrin Fab LM609 MUS MUSCULUS mus musculus mus musculus Backovic, M., Veesler, D., Borst, A.J., James, Z.M., Zagotta, W., Ginsberg, M., Rey, F.A., DiMaio, F. 2.26 X-RAY DIFFRACTION 0.255 0.213 False True IGHV5 IGKV5 Kappa None None None None None 4wcy H L 0 IMMUNE SYSTEM 09/05/14 Fab fragment of mouse AZ130 monoclonal antibody MUS MUSCULUS mus musculus mus musculus Fallecker, C., Tarbouriech, N., Habib, M., Crepin, T., Drouet, E. 2.0 X-RAY DIFFRACTION 0.224 0.172 False False IGHV14 IGKV3 Kappa None None None None None 2h32 H A 0 B protein NA immunoglobulin omega chain IMMUNE SYSTEM 05/22/06 Crystal structure of the pre-B cell receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bankovich, A.J. 2.7 X-RAY DIFFRACTION 0.295 0.267 False True unknown unknown unknown None None None None None 7mnm K M 0 B protein NA e3 sumo-protein ligase ranbp2 TRANSPORT PROTEIN/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T585M mutant in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 4.7 X-RAY DIFFRACTION 0.254 0.204 False True IGHV3 IGKV1 Kappa None None None None None 4xpf H L 0 A protein dopamine transporter-protein transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to RTI-55 MUS MUSCULUS; DROSOPHILA MELANOGASTER mus musculus mus musculus drosophila melanogaster Penmatsa, A., Wang, K.H., Gouaux, E. 3.273 X-RAY DIFFRACTION 0.296 0.241 False True IGHV5 IGKV4 Kappa None None None None None 6h7j D NA 0 B protein beta-1 adrenergic receptor IMMUNE SYSTEM 07/31/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama meleagris gallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g. 2.8 X-RAY DIFFRACTION 0.317 0.285 False True IGHV1 None None None None None 7kc9 F NA 0 E | D protein | protein NA | NA ricin chain b | ricin chain a TOXIN 10/05/20 Ricin bound to VHH antibody V5G1 VICUGNA PACOS; RICINUS COMMUNIS vicugna pacos ricinus communis | ricinus communis Rudolph, M.J. 2.301 X-RAY DIFFRACTION 0.238 0.187 False True IGHV1 NA NA None None None None None 3csy C D 0 N | M protein | protein NA | NA envelope glycoprotein gp2 | envelope glycoprotein gp1 IMMUNE SYSTEM/VIRAL PROTEIN 04/10/08 Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor HOMO SAPIENS; ZAIRE EBOLA VIRUS homo sapiens homo sapiens zaire ebola virus | zaire ebola virus Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O. 3.4 X-RAY DIFFRACTION 0.302 0.261 False True IGHV3 IGKV4 Kappa None None None None None 5tlk H G 0 Y protein cd27 antigen IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.7 X-RAY DIFFRACTION 0.263 0.213 False True IGHV3 IGKV1 Kappa None None None None None 1jtp A NA 0 L protein NA lysozyme c Antibody, Hydrolase 08/21/01 Degenerate interfaces in antigen-antibody complexes CAMELUS DROMEDARIUS; MELEAGRIS GALLOPAVO camelus dromedarius meleagris gallopavo Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L. 1.9 X-RAY DIFFRACTION 0.229 0.184 False True IGHV1 NA NA None None None None None 1r70 D C 0 IMMUNE SYSTEM 10/17/03 Model of human IgA2 determined by solution scattering, curve fitting and homology modelling HOMO SAPIENS homo sapiens homo sapiens Furtado, P.B., Whitty, P.W., Robertson, A., Eaton, J.T., Almogren, A., Kerr, M.A., Woof, J.M., Perkins, S.J. 30.0 SOLUTION SCATTERING / HOMOLOGY MODEL False True IGHV1 IGKV1 Kappa None None None None None 4ojf H L 0 A peptide amyloid beta a4 protein Immune System 01/21/14 Humanised 3D6 Fab complexed to amyloid beta 1-8 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Miles, L.A., Crespi, G.A.N., Parker, M.W. 1.998 X-RAY DIFFRACTION 0.215 0.172 False True IGHV3 IGKV2 Kappa None None None None None 2ltq F E 1 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 5jsa A B 0 C protein NA gp120 VIRAL PROTEIN/IMMUNE SYSTEM 05/07/16 Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, L., Wilson, I.A. 6.308 X-RAY DIFFRACTION 0.322 0.281 False True unknown IGLV2 Lambda None None None None None 3pnw E D 0 F protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 3juy E e 0 IMMUNE SYSTEM 09/15/09 Crystal Structure of a 3B3 Variant, a Broadly Neutralizing HIV-1 scFv Antibody HOMO SAPIENS homo sapiens Clark, K.R., Walsh, S.T. 2.5 X-RAY DIFFRACTION 0.260 0.195 True True unknown unknown unknown None None None None None 1i9r H L 0 A protein cd40 ligand CYTOKINE/IMMUNE SYSTEM 03/20/01 STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY HOMO SAPIENS homo sapiens homo sapiens homo sapiens Karpusas, M., Lucci, J., Ferrant, J., Benjamin, C., Hsu, Y.-M. 3.1 X-RAY DIFFRACTION 0.285 0.233 False False IGHV1 IGKV3D Kappa None None None None None 3et9 F f 0 IMMUNE SYSTEM 10/07/08 Crystal structure of the engineered neutralizing antibody 1H MUS MUSCULUS mus musculus Leysath, C.E., Monzingo, A.F., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D. 2.8 X-RAY DIFFRACTION 0.255 0.217 True True unknown unknown unknown None None None None None 2dlf H L 0 IMMUNE SYSTEM 12/17/98 HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FV FRAGMENT FROM AN ANTI-DANSYL SWITCH VARIANT ANTIBODY IGG2A(S) CRYSTALLIZED AT PH 6.75 MUS MUSCULUS mus musculus mus musculus Nakasako, M., Takahashi, H., Shimada, I., Arata, Y. 1.55 X-RAY DIFFRACTION 0.233 0.184 False False IGHV6 IGKV1 Kappa None None None None None 1ct8 B A 0 D Hapten TAA [4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]-PHOSPHONIC ACID MONO-[2-(2,2-DICHLORO-1-HYDROXY-ETHYLAMINO)-3-HYDROXY-1-(4-NITRO-PHENYL)-PROPYL] ESTER IMMUNE SYSTEM 08/20/99 CATALYTIC ANTIBODY 7C8 COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Tsumuraya, T., Fujii, I., Knossow, M. 2.2 X-RAY DIFFRACTION 0.275 0.211 False False IGHV1 IGKV5 Kappa 3e-07 -8.898798774188476 Unknown TBD 3mbx H L 0 IMMUNE SYSTEM 03/26/10 Crystal structure of chimeric antibody X836 MUS MUSCULUS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.6 X-RAY DIFFRACTION 0.232 0.210 False True IGHV8 IGKV8 Kappa None None None None None 3chn C O 1 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 6mph g i 0 B protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False False unknown IGKV3 Kappa None None None None None 1ruq H L 0 IMMUNE SYSTEM 12/11/03 Crystal Structure (H) of u.v.-irradiated Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected in house. MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 1.86 X-RAY DIFFRACTION 0.256 0.219 False False IGHV1 IGKV2 Kappa None None None None None 7zmn C NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-048 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.2 X-RAY DIFFRACTION 0.275 0.242 False True IGHV1 NA NA None None None None None 3ze2 H L 0 C protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.35 X-RAY DIFFRACTION 0.2037 0.1753 False True IGHV14 IGKV14 Kappa None None None None None 6mlk H L 0 A protein 6-deoxyerythronolide-b synthase erya3, modules 5 and 6 TRANSFERASE 09/27/18 Structure of Thioesterase from DEBS with a thioesterase-specific antibody SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Mathews, I.I., Li, X., Khosla, C. 2.45 X-RAY DIFFRACTION 0.235 0.175 False True IGHV4 IGKV2 Kappa 1.3e-08 -10.758506170369841 SPR TBD 1jgu H L 0 H Hapten HBC (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE IMMUNE SYSTEM 06/26/01 STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4 MUS MUSCULUS mus musculus mus musculus mus musculus Larsen, N.A., Heine, A., Crane, L., Cravatt, B.F., Lerner, R.A., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.229 0.209 False False IGHV5 IGKV1 Kappa None None None None None 7wsi H L 0 A protein NA sodium/bile acid cotransporter TRANSPORT PROTEIN 01/29/22 Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Asami, J., Shimizu, T., Ohto, U. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7bg1 H L 0 NA NA NA NA IMMUNE SYSTEM 01/05/21 Structure of anti-FLAG M2 Fab domain remodeled based on proteomic sequencing MUS MUSCULUS mus musculus mus musculus Pronker, M.F., Snijder, J. 1.86 X-RAY DIFFRACTION 0.255 0.217 False True IGHV1 IGKV1 Kappa None None None None None 3cdy NA B 0 IMMUNE SYSTEM 02/27/08 AL-09 H87Y, immuglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Aboagye, A.K., Thompson, J.R., Ramirez-Alvarado, M. 2.43 X-RAY DIFFRACTION 0.263 0.189 False True IGKV1 Kappa None None None None None 7lsi B D 0 NA NA NA NA ANTITUMOR PROTEIN,IMMUNE SYSTEM 02/18/21 Structure of KD035, a VEGFR2 monoclonal antibody HOMO SAPIENS homo sapiens homo sapiens Depetris, R.S. 2.4 X-RAY DIFFRACTION 0.274 0.197 False True IGHV3 IGLV3 Lambda None None None None None 7qia C NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/14/21 Structure of apo-EleNRMT in complex with two nanobodies at 3.5A EGGERTHELLA LENTA; SYNTHETIC CONSTRUCT synthetic construct eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1h8s A a 0 a Hapten AIC (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID ANTI-AMPICILLIN ANTIBODIES 02/15/01 Three-dimensional structure of anti-ampicillin single chain Fv fragment complexed with the hapten. MUS MUSCULUS mus musculus Burmester, J., Spinelli, S., Pugliese, L., Krebber, A., Honegger, A., Jung, S., Schimmele, B., Cambillau, C., Plucktun, A. 2.4 X-RAY DIFFRACTION 0.273 0.204 True True unknown unknown unknown 1.5399999999999999e-06 -7.92964050141843 Unknown TBD 7kqh C D 0 A protein NA hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 11/16/20 Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Bajic, G., Harrison, S.C. 3.5 X-RAY DIFFRACTION 0.300 0.252 False True IGHV3 IGKV1 Kappa None None None None None 7ew5 N O 0 J protein NA light chain of 13h5 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 5h37 G H 0 A protein structural protein e VIRUS/IMMUNE SYSTEM 10/20/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lim, X.-N., Ooi, J.S.G., Lambert, S., Tan, T.Y., Widman, D., Shi, J., Baric, R.S., Lok, S.-M. 4 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 2w0k NA B 0 IMMUNE SYSTEM 08/19/08 Crystal structure of the recombinant variable domain 6JAL2 HOMO SAPIENS homo sapiens Rudino-Pinera, E., Gonzalezrubio-Garrido, P., Horjales, E. 2.35 X-RAY DIFFRACTION 0.242 0.209 False False IGLV6 Lambda None None None None None 6ieq H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN 09/16/18 Crystal Structure of HIV-1 Env ConM SOSIP.v7 in Complex with bNAb PGT124 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Han, B.W., Wilson, I.A. 3.9 X-RAY DIFFRACTION 0.296 0.247 False True IGHV4 unknown unknown None None None None None 7qn5 G NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6mw9 G H 0 F protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-3 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 7ejy H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/03/21 Complex Structure of antibody BD-503 and RBD of COVID-19 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xu, H., Wang, B., Zhao, T.N., Su, X.D. 3.04 X-RAY DIFFRACTION 0.254 0.214 False True IGHV3 IGKV1 Kappa None None None None None 6tys F G 0 E protein fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 08/09/19 A potent cross-neutralizing antibody targeting the fusion glycoprotein inhibits Nipah virus and Hendra virus infection NIPAH VIRUS; MUS MUSCULUS mus musculus mus musculus nipah virus Dang, H.V., Chan, Y.P., Park, Y.J., Snijder, J., Da Silva, S.C., Vu, B., Yan, L., Feng, Y.R., Rockx, B., Geisbert, T., Mire, C.E., Broder, C.B., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.5 ELECTRON MICROSCOPY False True IGHV5 IGKV12 Kappa None None None None None 2x7l C D 0 P protein hiv rev IMMUNE SYSTEM 03/01/10 Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element UNCLASSIFIED; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 BH10 unclassified unclassified human immunodeficiency virus type 3 DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M. 3.17 X-RAY DIFFRACTION 0.2500 0.2337 False True IGHV1 IGKV1 Kappa None None None None None 6d11 C D 0 E peptide nanp5 IMMUNE SYSTEM 04/11/18 Crystal structure of 1450 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Imkeller, K., Wardemann, H., Julien, J.P. 3.4 X-RAY DIFFRACTION 0.299 0.254 False True IGHV3 IGKV1 Kappa None None None None None 5hvf B NA 0 A protein carboxypeptidase b2 hydrolase/hydrolase inhibitor 01/28/16 Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83) VICUGNA PACOS; HOMO SAPIENS vicugna pacos homo sapiens Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 2.85 X-RAY DIFFRACTION 0.230 0.192 False True IGHV1 3e-11 -14.355775131829494 SPR TBD 7l6v F NA 0 A protein NA bont/a ANTITOXIN 12/24/20 Crystal structure of BoNT/A-LC-JPU-A5-JPU-C1-JPU-H7-JPU-D12-ciA-F12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.01 X-RAY DIFFRACTION 0.234 0.197 False True IGHV1 NA NA None None None None None 3chn D N 3 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 2kh2 B b 8 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5ken N O 0 M protein ebola surface glycoprotein, gp2 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76); ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV1 IGKV12 Kappa None None None None None 4why K L 0 C peptide epitope peptide VIRAL PROTEIN 09/24/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P21 crystal form RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.62 X-RAY DIFFRACTION 0.258 0.204 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 1plg H L 0 IMMUNOGLOBULIN 04/24/95 EVIDENCE FOR THE EXTENDED HELICAL NATURE OF POLYSACCHARIDE EPITOPES. THE 2.8 ANGSTROMS RESOLUTION STRUCTURE AND THERMODYNAMICS OF LIGAND BINDING OF AN ANTIGEN BINDING FRAGMENT SPECIFIC FOR ALPHA-(2->8)-POLYSIALIC ACID MUS MUSCULUS mus musculus mus musculus Evans, S.V., Sigurskjold, B.W., Jennings, H.J., Brisson, J.-R., Tse, W.C., To, R., Altman, E., Frosch, M., Weisgerber, C., Kratzin, H., Klebert, S., Vaesen, M., Bitter-Suermann, D., Rose, D.R., Young, N.M., Bundle, D.R. 2.8 X-RAY DIFFRACTION unknown 0.164 False False IGHV1 IGKV1 Kappa None None None None None 6f7t B A 0 D peptide ribonuclease y IMMUNE SYSTEM 12/11/17 Crystal Structure of an Fab fragment in complex with a peptide from Bacillus subtilis RNase Y MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus bacillus subtilis Golinelli-Pimpaneau, B., Hardouin, P. 2.6 X-RAY DIFFRACTION 0.253 0.202 False False IGHV9 IGLV3 Lambda 3.6e-10 -12.883508495506627 Unknown TBD 7tus A B 0 NA NA NA NA IMMUNE SYSTEM 02/03/22 Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation HOMO SAPIENS homo sapiens homo sapiens Park, H., Rader, C. 2.4 X-RAY DIFFRACTION 0.257 0.218 False True IGHV6 IGKV1 Kappa None None None None None 7o85 NA H 0 G | I protein | protein NA | NA protective antigen pa-63 | fab TOXIN 04/14/21 Anthrax toxin prepore in complex with the neutralizing Fab cAb29 BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus bacillus anthracis | mus musculus Hoelzgen, F., Zalk, R., Alcalay, R., Cohen-Schwartz, S., Garau, G., Shahar, A., Mazor, O., Frank, G.A. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 5f3h A B 0 J protein growth/differentiation factor 8 Signaling Protein/Immune System 12/02/15 Structure of myostatin in complex with humanized RK35 antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Parris, K.D., Mosyak, L. 2.7 X-RAY DIFFRACTION 0.270 0.218 False True IGHV3 IGKV1 Kappa None None None None None 6j71 B b 0 A protein receptor tyrosine-protein kinase erbb-2 SIGNALING PROTEIN 01/16/19 HuA21-scFv in complex with the extracellular domain(ECD) of HER2 HOMO SAPIENS; MURINE ADENOVIRUS 1 murine adenovirus 1 homo sapiens Wang, Z., Guo, G., Cheng, B., Zhu, Z., Niu, L., Zhang, H. 2.918 X-RAY DIFFRACTION 0.267 0.208 True True unknown unknown unknown None None None None None 3cdy NA A 0 IMMUNE SYSTEM 02/27/08 AL-09 H87Y, immuglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Aboagye, A.K., Thompson, J.R., Ramirez-Alvarado, M. 2.43 X-RAY DIFFRACTION 0.263 0.189 False True IGKV1 Kappa None None None None None 1g9e A NA 19 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6dzz B C 0 A protein sodium-dependent serotonin transporter TRANSPORT PROTEIN/IMMUNE SYSTEM 07/05/18 Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8 Fab in the inward conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Coleman, J.A., Gouaux, E. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 4nrx A B 0 C peptide envelope glycoprotein gp41 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66 in complex with gp41 MPER peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Yang, Y., Kwong, P.D. 2.21 X-RAY DIFFRACTION 0.215 0.188 False True IGHV5 IGKV1 Kappa None None None None None 5uk1 G g 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 3 HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); INFLUENZA A VIRUS homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 5u3k H L 0 P peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.2 Fab in Complex with HIV-1 gp41 MPER 662-683 Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 2.637 X-RAY DIFFRACTION 0.283 0.232 False True IGHV3 IGKV1 Kappa None None None None None 2vir B A 0 C protein hemagglutinin COMPLEX (HEMAGGLUTININ/IMMUNOGLOBULIN) 12/22/97 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Bizebard, T., Fleury, D., Gigant, B., Wharton, S.A., Skehel, J.J., Knossow, M. 3.25 X-RAY DIFFRACTION 0.249 0.198 False False IGHV2 IGLV1 Lambda 1.00e-09 -12.27 Other 25 9461077 6ru5 C NA 0 B | A protein | protein NA | NA complement c3 | complement c3 IMMUNE SYSTEM 05/27/19 human complement C3 in complex with the hC3Nb1 nanobody LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Jensen, R.K., Andersen, G.R. 3.9 X-RAY DIFFRACTION unknown unknown False True IGHV1 None None None None None 7wpd X Y 0 A protein NA spike glycoprotein VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with one JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7pi2 B C 0 A protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to monoclonal antibody Cy.003 Fab fragment PLASMODIUM FALCIPARUM (ISOLATE 3D7); GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 3.14 X-RAY DIFFRACTION 0.239 0.219 False True unknown unknown unknown None None None None None 7zmq K NA 0 A protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2*-006 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.7 X-RAY DIFFRACTION 0.258 0.225 False True IGHV1 NA NA None None None None None 7ndb H L 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-253H165L Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 4.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6qn8 A B 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV Fab B13 BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.12 X-RAY DIFFRACTION 0.267 0.235 False True IGHV1 IGLV1 Lambda None None None None None 6knm A NA 0 B protein apelin receptor,rubredoxin,apelin receptor MEMBRANE PROTEIN 08/06/19 Apelin receptor in complex with single domain antibody HOMO SAPIENS; CLOSTRIDIUM PASTEURIANUM; CAMELUS BACTRIANUS camelus bactrianus homo sapiens, clostridium pasteurianum Ma, Y.B., Ding, Y., Song, X., Ma, X., Li, X., Zhang, N., Song, Y., Sun, Y., Shen, Y., Zhong, W., Hu, L.A., Ma, Y.L., Zhang, M.Y. 3.2 X-RAY DIFFRACTION 0.305 0.258 False True IGHV1 None None None None None 7nk4 F NA 0 A protein NA polymerase acidic protein VIRAL PROTEIN 02/17/21 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); CAMELIDAE MIXED LIBRARY; SYNTHETIC CONSTRUCT camelidae mixed library influenza a virus (a/brevigmission/1/1918(h1n1)) Keown, J.R., Carrique, L., Fodor, E., Grimes, J.M. 5.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6opa K J 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/01/20 Crystal structure of bovine Fab NC-Cow1 in complex with HIV-1 BG505 SOSIP.664, and human Fabs 35022 and PGT128 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Stanfield, R.L., Wilson, I.A. 4.084 X-RAY DIFFRACTION 0.343 0.332 False True unknown IGLV2 Lambda None None None None None 6o28 A B 0 E peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein KQPA and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 1.93 X-RAY DIFFRACTION 0.219 0.188 False True IGHV3 IGKV3 Kappa None None None None None 3cm9 C N 4 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6l98 NA A 0 NA NA NA NA IMMUNE SYSTEM 11/08/19 Crystalline cast nephropathy-causing Bence-Jones protein AK: An entire immunoglobulin lambda light chain dimer HOMO SAPIENS homo sapiens Nakagaki, T., Noguchi, K., Yohda, M., Odaka, M., Wakui, H., Matsumura, H. 1.77 X-RAY DIFFRACTION 0.265 0.229 False True NA IGLV3 Lambda None None None None None 7te8 A NA 0 C Hapten P0T cannabidiol BIOSYNTHETIC PROTEIN 01/04/22 CA14-CBD-DB21 ternary complex ARTIFICIAL SEQUENCES artificial sequences artificial sequences Cao, S., Zheng, N. 1.998 X-RAY DIFFRACTION 0.211 0.180 False True IGHV3 NA NA None None None None None 5mu2 E F 0 R peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 7n0i I NA 0 A | B protein | protein NA | NA nucleoprotein | nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/25/21 Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Ye, Q., Corbett, K.D. 2.2 X-RAY DIFFRACTION 0.271 0.239 False True IGHV1 NA NA None None None None None 6usf K M 0 A protein chimera of soluble cytochrome b562 (bril) and neuronalacetylcholine receptor subunit alpha-4 MEMBRANE PROTEIN/IMMUNE SYSTEM 10/26/19 CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 HOMO SAPIENS; ESCHERICHIA COLI homo sapiens homo sapiens homo sapiens, escherichia coli Alvarez, F.J.D., Mukherjee, S., Han, S., Ammirati, M., Kossiakoff, A.A. 3.87 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6mxs H L 0 IMMUNE SYSTEM 10/31/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98F,HC-G99M] HOMO SAPIENS homo sapiens homo sapiens Shi, R., Picard, M.-E., Manenda, M.S. 1.95 X-RAY DIFFRACTION 0.229 0.191 False True IGHV3 IGKV1 Kappa None None None None None 7rga A NA 0 A Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoCLAMP3:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Alexandrov, K. 2.9 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 6dzl G J 0 E | A protein | protein NA | NA ebola virus makona gp2 | ebola virus makona gp1 VIRAL PROTEIN 07/05/18 Ebola virus Makona variant GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus | zaire ebolavirus Murin, C.D., Ward, A.B. 4.14 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6vl9 H L 0 H Hapten 9FO 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol IMMUNE SYSTEM 01/23/20 Anti-PEG antibody 6-3 Fab fragment in complex with PEG MUS MUSCULUS mus musculus mus musculus mus musculus Nicely, N.I., Huckaby, J.T., Lai, S.K., Jacobs, T.M. 2.63 X-RAY DIFFRACTION 0.250 0.178 False True IGHV9 IGKV8 Kappa None None None None None 7pi3 a b 0 V protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False False unknown unknown unknown None None None None None 7d0c H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-3A1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Wang, R.K., Yu, J.F., Zhang, Y.Y., Liu, N., Wang, H.W., Wang, X.Q., Zhang, L.Q., Zhou, Q. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 1tzh H L 0 V protein vascular endothelial growth factor a immune system 07/09/04 Crystal Structure of the Fab YADS1 Complexed with h-VEGF HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Fellouse, F.A., Wiesmann, C., Sidhu, S.S. 2.6 X-RAY DIFFRACTION 0.271 0.212 False True IGHV5 IGKV12 Kappa 1.80E-09 -12.4 SPR 37 15306681 6e3h H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 viral protein/immune system 07/14/18 Crystal structure of S9-3-37 bound to H5 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.248 0.205 False True IGHV1 IGKV2 Kappa None None None None None 4u7s A NA 0 IMMUNE SYSTEM 07/31/14 Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) Crystallized for 5 months LAMA GLAMA lama glama Legler, P.M. 2.07 X-RAY DIFFRACTION 0.242 0.232 False True IGHV1 None None None None None 1n6q H L 0 B protein reverse transcriptase TRANSFERASE/IMMUNE SYSTEM/DNA 11/11/02 HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N) HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, I., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E. 3.0 X-RAY DIFFRACTION 0.284 0.247 False False IGHV8 IGKV10 Kappa None None None None None 4zso B A 0 E protein natural cytotoxicity triggering receptor 3 ligand 1 IMMUNE SYSTEM 05/13/15 Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xu, X., Li, Y., Mariuzza, R.A. 2.5 X-RAY DIFFRACTION 0.257 0.226 False True IGHV1 IGKV4 Kappa None None None None None 7k8q H L 0 NA NA NA NA IMMUNE SYSTEM 09/27/20 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C110 HOMO SAPIENS homo sapiens homo sapiens Abernathy, M.E., Barnes, C.O., Bjorkman, P.J. 2.0 X-RAY DIFFRACTION 0.243 0.205 False True IGHV1 IGLV2 Lambda None None None None None 3cfj F E 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, orthorhombic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.253 0.199 False True IGHV4 IGLV1 Lambda None None None None None 6n51 C NA 0 A protein metabotropic glutamate receptor 5 MEMBRANE PROTEIN 11/20/18 Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K. 4 ELECTRON MICROSCOPY False True IGHV1 None None None None None 4r96 F E 0 Immune System 09/03/14 Structure of a Llama Glama Fab 48A2 against human cMet LLAMA GLAMA lama glama lama glama Klarenbeek, A., El Mazouari, K., Desmyter, A., Blanchetot, C., Hultberg, A., Roovers, R.C., Cambillau, C., Spinelli, S., Del-Favero, J., Verrips, T., de Haard, H., Achour, I. 3.31 X-RAY DIFFRACTION 0.261 0.217 False True IGHV1 IGKV4 Kappa None None None None None 4fqq F E 0 IMMUNE SYSTEM 06/25/12 Crystal Structure of Germline Antibody PGT121-GL Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 2.42 X-RAY DIFFRACTION 0.237 0.194 False True IGHV4 IGLV3 Lambda None None None None None 7nxb A B 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.67 X-RAY DIFFRACTION 0.246 0.213 False True IGHV3 IGKV3 Kappa None None None None None 7lpn H NA 0 G protein NA envelope glycoprotein gp160 VIRAL PROTEIN 02/12/21 Cryo-EM structure of llama J3 VHH antibody in complex with HIV-1 Env BG505 DS-SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.61 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 2ht4 E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/25/06 Structure of the Escherichia coli ClC chloride channel Y445W mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.2 X-RAY DIFFRACTION 0.261 0.239 False False IGHV4 IGKV4 Kappa None None None None None 2gjj b B 0 IMMUNE SYSTEM 03/31/06 Crystal structure of a single chain antibody scA21 against Her2/ErbB2 MUS MUSCULUS mus musculus Zhu, Z. 2.1 X-RAY DIFFRACTION 0.226 0.189 True True unknown unknown unknown None None None None None 5npj B b 0 E peptide epitope peptide VIRAL PROTEIN 04/16/17 Structure of the Hepatitis C virus strain JFH1 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus hepatitis c virus Vasiliauskaite, I., Rey, F.A., Krey, T. 1.9 X-RAY DIFFRACTION 0.202 0.186 True True unknown unknown unknown None None None None None 5ivn A NA 0 B peptide cadherin derived peptide PEPTIDE BINDING PROTEIN 03/21/16 BC2 nanobody in complex with the BC2 peptide tag VICUGNA PACOS; SYNTHETIC CONSTRUCT vicugna pacos homo sapiens Braun, M.B., Stehle, T. 1.0 X-RAY DIFFRACTION 0.150 0.128 False True IGHV1 1.4e-09 -12.078842495721123 Unknown TBD 6xc4 X Y 0 Z protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.3 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 2.341 X-RAY DIFFRACTION 0.219 0.184 False True IGHV3 IGKV3 Kappa None None None None None 7l02 H L 0 T carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 12/10/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Manne, K., Henderson, R., Acharya, P. 3.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7jtr F f 0 E protein NA maltose/maltodextrin-binding periplasmic protein SUGAR BINDING PROTEIN/IMMUNE SYSTEM 08/18/20 Complex of maltose-binding protein (MBP) with single-chain Fv (scFv) MUS MUSCULUS; ESCHERICHIA COLI mus musculus escherichia coli Loll, P.J. 2.5 X-RAY DIFFRACTION 0.237 0.201 True True unknown unknown unknown None None None None None 2i60 R Q 0 P protein exterior membrane glycoprotein(gp120) VIRAL PROTEIN/IMMUNE SYSTEM 08/26/06 Crystal structure of [Phe23]M47, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 GP120 envelope glycoprotein and anti-HIV-1 antibody 17B HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.-C., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.281 0.215 False True IGHV1 IGKV3 Kappa 6.240000000000001e-09 -11.193370928227925 SPR TBD 6ibl D NA 0 B protein thioredoxin 1,beta-1 adrenergic receptor IMMUNE SYSTEM 11/30/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY Nb80 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama escherichia coli (strain k12), meleagrisgallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G. 2.7 X-RAY DIFFRACTION 0.277 0.240 False True IGHV1 None None None None None 2g60 H L 0 IMMUNE SYSTEM 02/23/06 Structure of anti-FLAG M2 Fab domain MUS MUSCULUS mus musculus mus musculus Roosild, T.P. 1.85 X-RAY DIFFRACTION 0.278 0.235 False False IGHV1 IGKV1 Kappa None None None None None 7e9n P O 0 B protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 03/04/21 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7s8p E e 0 B | C protein | protein NA | NA gs-mini-gq chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 09/18/21 CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134 HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI mus musculus homo sapiens | homo sapiens Cao, C., Fay, J.F., Gumpper, R.H., Roth, B.L. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7q6e J K 0 C protein NA spike glycoprotein VIRAL PROTEIN 11/07/21 Beta049 fab in complex with SARS-CoV2 beta-Spike glycoprotein, The Beta mAb response underscores the antigenic distance to other SARS-CoV-2 variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3rif I O 0 D protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.345 X-RAY DIFFRACTION 0.271 0.248 False True IGHV1 IGLV1 Lambda None None None None None 6zg3 E NA 0 A | I protein | protein NA | NA energy-coupling factor transporter atp-binding proteinecfa1 | putative cobalt abc transporter, permease protein TRANSPORT PROTEIN 06/18/20 the structure of ECF PanT transporter in a complex with a nanobody LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS ATCC 11842 = JCM 1002; LAMA GLAMA lama glama lactobacillus delbrueckii subsp. bulgaricusatcc 11842 = jcm 1002 | lactobacillus delbrueckii subsp. bulgaricusatcc 11842 = jcm 1002 Setyawati, I., Guskov, A., Slotboom, D.J. 2.8 X-RAY DIFFRACTION 0.276 0.242 False False IGHV1 NA NA None None None None None 4yzf I J 0 C protein band 3 anion transport protein IMMUNE SYSTEM 03/25/15 Crystal structure of the anion exchanger domain of human erythrocyte Band 3 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alguel, Y., Arakawa, T., Yugiri, T.K., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Suno, C.I., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A.D., Kobayashi, T., Hamasaki, N., Iwata, S. 3.5 X-RAY DIFFRACTION 0.290 0.274 False False IGHV8 IGKV3 Kappa None None None None None 7mlv G J 0 B protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7k43 H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/14/20 SARS-CoV-2 spike in complex with the S2M11 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7lex Q O 0 N protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1vhp A NA 7 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4org H L 0 IMMUNE SYSTEM 02/11/14 Crystal structure of human Fab CAP256-VRC26.04, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 3.121 X-RAY DIFFRACTION 0.289 0.275 False True IGHV3 IGLV1 Lambda None None None None None 6ln2 C B 0 A protein glucagon-like peptide 1 receptor,rubredoxin,glucagon-likepeptide 1 receptor MEMBRANE PROTEIN 12/28/19 Crystal structure of full length human GLP1 receptor in complex with Fab fragment (Fab7F38) HOMO SAPIENS; CLOSTRIDIUM PASTEURIANUM; MUS MUSCULUS mus musculus mus musculus homo sapiens, clostridium pasteurianum Wu, F., Yang, L., Hang, K., Laursen, M., Wu, L., Han, G.W., Ren, Q., Roed, N.K., Lin, G., Hanson, M., Jiang, H., Wang, M., Reedtz-Runge, S., Song, G., Stevens, R.C. 3.2 X-RAY DIFFRACTION 0.262 0.213 False True IGHV1 IGKV4 Kappa None None None None None 2fl5 D C 0 D Hapten RBF RIBOFLAVIN IMMUNE SYSTEM 01/05/06 Cofactor-containing antibodies: Crystal structure of the original yellow antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.290 0.240 False False IGHV3 IGLV3 Lambda 1.8000000000000002e-09 -11.929942798416155 Unknown TBD 6ba5 D C 0 N protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/12/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.62 X-RAY DIFFRACTION 0.214 0.194 False True IGHV1 IGKV1 Kappa None None None None None 4yhl H L 0 IMMUNE SYSTEM 02/27/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens Schiele, F., Nar, H. 2.09 X-RAY DIFFRACTION 0.221 0.181 False True IGHV1 IGKV1 Kappa None None None None None 6yla B C 0 A protein sars-cov-2 rbd VIRAL PROTEIN 04/06/20 Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huo, J., Zhao, Y., Ren, J., Zhou, D., Ginn, H.M., Fry, E.E., Owens, R., Stuart, D.I. 2.42 X-RAY DIFFRACTION 0.237 0.213 False True IGHV5 IGKV4 Kappa None None None None None 6snd B A 0 C peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.1 X-RAY DIFFRACTION 0.267 0.238 False True IGHV4 IGKV1 Kappa None None None None None 4bh7 B A 0 P peptide dodecapeptide antigen IMMUNE SYSTEM 03/30/13 CRYSTAL STRUCTURE OF GERMLINE ANTIBODY 36-65 IN COMPLEX WITH PEPTIDE PPYPAWHAPGNI MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.89 X-RAY DIFFRACTION 0.25419 0.22733 False False IGHV1 IGKV10 Kappa None None None None None 4g5z H L 0 IMMUNE SYSTEM 07/18/12 Crystal structure of the therapeutical antibody fragment of canakinumab in its unbound state homo sapiens homo sapiens Blech, M., Hoerer, S. 1.83 X-RAY DIFFRACTION 0.222 0.193 False True IGHV3 IGKV1 Kappa None None None None None 5wca H L 0 IMMUNE SYSTEM 06/29/17 Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 27-1C08 Fab. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Andrews, S.F., Mascola, J.R., McDermott, A.B., Kwong, P.D. 1.369 X-RAY DIFFRACTION 0.182 0.165 False True IGHV1 IGLV2 Lambda None None None None None 6wit A B 0 C protein NA 16055 v1v2 1fd6 scaffold ANTIVIRAL PROTEIN/IMMUNE SYSTEM 04/10/20 Crystal structure of NHP D15.SD7 Fab in complex with 16055 V1V2 1FD6 scaffold MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta homo sapiens Liban, T., Aljedani, S., Rodarte, J., Pancera, M. 2.79 X-RAY DIFFRACTION 0.284 0.224 False True IGHV1 IGLV6 Lambda None None None None None 7kc1 J K 0 I | G protein | protein NA | NA fusion protein of hemagglutinin and envelope glycoprotein | hemagglutinin IMMUNE SYSTEM 10/04/20 Cryo-EM structure of SRR2899884.46167H+MEDI8852L fab in complex with Victoria HA INFLUENZA A VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens influenza a virus, human immunodeficiency virus1 | influenza a virus Gorman, J., Kwong, P.D. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV1 Kappa None None None None None 7f35 D C 0 C Hapten GFN 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid IMMUNE SYSTEM 06/15/21 Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with S-gatifloxacin MUS MUSCULUS mus musculus mus musculus mus musculus Wang, L.T., Jiao, W.Y., Shen, X., Lei, H.T. 2.6 X-RAY DIFFRACTION 0.235 0.200 False False IGHV1 IGKV3 Kappa None None None None None 6edu T U 0 E | C protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 IMMUNE SYSTEM 08/11/18 B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4.06 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7tht a c 0 S protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/12/22 CryoEM structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1042 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., May, A., Acharya, P. 3.42 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 6sf6 H L 0 C peptide NA p6 epitope of cartilage oligomeric matrix protein (comp) IMMUNE SYSTEM 08/01/19 Crystal structure of the mAb 15A in complex with COMP-epitope P6 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus rattus norvegicus Dobritzsch, D., Ge, C., Holmdahl, R. 1.9 X-RAY DIFFRACTION 0.203 0.174 False True IGHV1 IGKV1 Kappa None None None None None 6k7o D E 0 Q protein NA leukocyte immunoglobulin-like receptor subfamily b member4 IMMUNE SYSTEM 06/08/19 Complex structure of LILRB4 and h128-3 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Song, H., Chai, Y., Xu, X., Gao, F.G. 3.004 X-RAY DIFFRACTION 0.270 0.228 False True IGHV3 IGKV1 Kappa None None None None None 6okp O P 0 E protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/14/19 B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.28 ELECTRON MICROSCOPY False True IGHV4 IGKV3 Kappa None None None None None 7nx3 B C 0 F protein NA alk tyrosine kinase receptor PROTEIN BINDING 03/17/21 Crystal structure of ALK in complex with Fab324 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens De Munck, S., Savvides, S.N. 2.81 X-RAY DIFFRACTION 0.266 0.228 False True IGHV1 IGKV3 Kappa None None None None None 7b18 F NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/24/20 SARS-CoV-spike bound to two neutralising nanobodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; VICUGNA PACOS lama glama severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.62 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5l6y H L 0 C protein interleukin-13 IMMUNE SYSTEM 06/01/16 il13 in complex with tralokinumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Breed, J. 1.99 X-RAY DIFFRACTION 0.211 0.189 False True IGHV1 IGLV3 Lambda 5.8e-11 -13.965182855604231 SPR TBD 5bk0 D C 0 IMMUNE SYSTEM 09/12/17 Crystal structure of 663 Fab bound to circumsporozoite protein NANP 5-mer HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 3.15 X-RAY DIFFRACTION 0.274 0.235 False True IGHV3 IGKV2 Kappa None None None None None 6a0x A B 0 IMMUNE SYSTEM 06/06/18 Crystal structure of broadly neutralizing antibody 13D4 MUS MUSCULUS mus musculus mus musculus Li, S., Li, T. 2.3 X-RAY DIFFRACTION 0.243 0.205 False False IGHV1 IGKV6 Kappa None None None None None 7phu D E 0 A protein NA reticulocyte-binding protein homolog 5 IMMUNE SYSTEM 08/18/21 PfRH5 bound to monoclonal antibody R5.015 and R5.016 Fab fragments PLASMODIUM FALCIPARUM (ISOLATE 3D7); HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Ragotte, R.J., Higgins, M.K. 2.53 X-RAY DIFFRACTION 0.276 0.236 False True IGHV1 IGKV1 Kappa None None None None None 6ii4 H L 0 A protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L4A-14 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.3 X-RAY DIFFRACTION 0.276 0.227 False True IGHV3 IGLV6 Lambda 1.6600000000000003e-08 -10.613671557141997 SPR TBD 6z3k M N 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 1rum H L 0 immune system 12/11/03 Crystal structure (F) of H2O2-soaked cationic cyclization antibody 4C6 fab at pH 8.5 with a data set collected at SSRL beamline 9-1. MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 1.48 X-RAY DIFFRACTION unknown unknown False False IGHV3 IGKV1 Kappa None None None None None 6mwv G H 0 F protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-58 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 6me1 C D 0 E peptide envelope glycoprotein gp160 VIRAL PROTEIN 09/05/18 Crystal structure of the clade B isolate B41 mutant fusion peptide (residues 512-521) in complex with VRC34.01 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus type 1 Kumar, S., Sarkar, A., Wilson, I.A. 1.97 X-RAY DIFFRACTION 0.238 0.199 False True IGHV1 IGKV1 Kappa None None None None None 2p45 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.1A resolution: SE5B-ORTHO-1 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 1.1 X-RAY DIFFRACTION 0.195 0.173 False True IGHV1 1.16e-07 -9.61 Other 30 18445622 5if0 H L 0 G protein germline-targeting hiv-1 gp120 engineered outer domain eod-gt8 IMMUNE SYSTEM/VIRAL PROTEIN 02/25/16 Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.44 A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sarkar, A., Wilson, I.A. 2.44 X-RAY DIFFRACTION 0.232 0.191 False True IGHV1 IGKV4 Kappa None None None None None 6dwi B A 0 NA NA NA NA IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 7sfw M N 0 B protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 (focus refine of the asymmetric unit) VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 7qf0 H L 0 A protein NA spike protein s1 VIRAL PROTEIN 12/03/21 Crystal structure of the SARS-CoV-2 RBD in complex with the human antibody CV2.2325 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fernandez, I., Pederzoli, R., Rey, F.A. 2.3 X-RAY DIFFRACTION 0.221 0.185 False True IGHV3 IGKV1 Kappa None None None None None 6mqc H L 0 C peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 10/09/18 Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-c.01 in complex with FP (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.234 0.199 False True IGHV4 IGKV2 Kappa None None None None None 7tbf D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/21 Locally refined region of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4ogy M N 0 B protein plasma kallikrein HYDROLASE/ANTIBODY 01/16/14 Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Edwards, T.E., Clifton, M.C., Abendroth, J., Nixon, A., Ladner, R. 2.1 X-RAY DIFFRACTION 0.221 0.183 False True IGHV3 IGKV1 Kappa None None None None None 2cd0 NA B 0 IMMUNE SYSTEM 03/08/99 STRUCTURE OF HUMAN LAMBDA-6 LIGHT CHAIN DIMER WIL HOMO SAPIENS homo sapiens Pokkuluri, P.R., Solomon, A., Weiss, D.T., Stevens, F.J., Schiffer, M. 1.8 X-RAY DIFFRACTION 0.351 0.289 False True IGLV6 Lambda None None None None None 7w57 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/21 Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens You, C., Xu, H.E., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7z1b E NA 0 C protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-A10 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.3 X-RAY DIFFRACTION 0.243 0.198 False True IGHV1 NA NA None None None None None 1maj NA A 14 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 6z3k C D 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 7k9z B A 0 E protein NA spike glycoprotein IMMUNE SYSTEM 09/29/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with the Fab fragments of neutralizing antibodies 298 and 52 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Newton, J.C., Kucharska, I., Rujas, E., Cui, H., Julien, J.P. 2.95 X-RAY DIFFRACTION 0.287 0.261 False True IGHV1 IGKV4 Kappa None None None None None 1u95 B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/09/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDHWAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.24 X-RAY DIFFRACTION 0.238 0.210 False False IGHV2 IGKV1 Kappa None None None None None 5t1m D C 0 IMMUNE SYSTEM 08/19/16 Cetuximab Fab in complex with CQYDLSTRRLKC MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.53 X-RAY DIFFRACTION 0.216 0.153 False True IGHV2 IGKV5 Kappa 1.5e-06 -7.945233077098003 Unknown TBD 1jvk NA B 0 IMMUNE SYSTEM 08/30/01 THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR HOMO SAPIENS homo sapiens Bourne, P.C., Ramsland, P.A., Shan, L., Fan, Z.-C., DeWitt, C.R., Shultz, B.B., Terzyan, S.S., Edmundson, A.B. 1.94 X-RAY DIFFRACTION 0.254 0.221 False False IGLV2 Lambda None None None None None 3bz4 D C 0 D carbohydrate RAM polysaccharide IMMUNE SYSTEM 01/17/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag decasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.230 0.176 False False IGHV6 IGKV2 Kappa None None None None None 6qig H L 0 A protein a disintegrin and metalloproteinase with thrombospondinmotifs 13 BLOOD CLOTTING 01/18/19 Metalloproteinase HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Kim, H.J., Emsley, J. 2.8 X-RAY DIFFRACTION 0.247 0.206 False False IGHV5 IGKV5 Kappa None None None None None 1rvf H L 0 1 | 3 protein | protein NA | NA human rhinovirus 14 coat protein | human rhinovirus 14 coat protein VIRUS/IMMUNE SYSTEM 09/05/96 FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS HUMAN RHINOVIRUS 14; HUMAN RHINOVIRUS SP.; MUS MUSCULUS mus musculus mus musculus human rhinovirus 14 | human rhinovirus 14 Smith, T.J. 4.0 X-RAY DIFFRACTION unknown 0.212 False False IGHV1 IGKV4 Kappa None None None None None 2kh2 B b 12 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7cwm G J 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 Complex of SARS-CoV-2 spike protein and Fab P17 with one RBD in open state and two RBD in closed state SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6xw7 H NA 0 F protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5829 and glycochenodeoxycholate (GCDCA) MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 2.15 X-RAY DIFFRACTION 0.215 0.171 False True IGHV1 None None None None None 4rrp H B 0 N protein antigen asf1p IMMUNE SYSTEM 11/06/14 Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Kuzin, A., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Oconnell, P.T., Maglaqui, M., Bailey, L., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG) 2.79 X-RAY DIFFRACTION 0.253 0.183 False True IGHV3 IGKV1 Kappa None None None None None 6h71 C NA 0 A protein NA capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-94 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 2.313 X-RAY DIFFRACTION 0.217 0.193 False True IGHV1 NA NA None None None None None 6o3g C D 0 Q peptide meper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41). HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 3.645 X-RAY DIFFRACTION 0.289 0.260 False True IGHV1 IGKV3 Kappa None None None None None 7lrt D E 0 C protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/17/21 Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody A23-58.1 that targets the receptor-binding domain HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T. 3.54 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2hvj A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 07/28/06 Crystal structure of KcsA-Fab-TBA complex in low K+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Zhou, Y. 2.75 X-RAY DIFFRACTION 0.246 0.222 False False IGHV1 IGKV5 Kappa None None None None None 1mrd H L 0 L Hapten IDP INOSINE-5'-DIPHOSPHATE IMMUNOGLOBULIN 06/13/94 PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB-MONONUCLEOTIDE COMPLEXES MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Cygler, M. 2.3 X-RAY DIFFRACTION unknown 0.195 False True IGHV1 IGKV1 Kappa None None None None None 6e5p I J 0 E protein envelope glycoprotein gp120 VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 5xbm B A 0 C protein lysosome membrane protein 2 IMMUNE SYSTEM/PROTEIN BINDING 03/20/17 Structure of SCARB2-JL2 complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhang, X., Yang, P., Wang, N., Zhang, J., Li, J., Guo, H., Yin, X., Rao, Z., Wang, X., Zhang, L. 3.501 X-RAY DIFFRACTION 0.293 0.238 False False IGHV1 IGKV5 Kappa None None None None None 5nmv H L 0 K protein tissue factor pathway inhibitor IMMUNE SYSTEM 04/07/17 Crystal structure of 2F22 Fab fragment against TFPI1 MUS; HOMO SAPIENS mus mus homo sapiens Svensson, L.A., Petersen, H.H. 1.65 X-RAY DIFFRACTION 0.202 0.175 False True IGHV2 IGKV6 Kappa 1e-09 -12.27819680469229 SPR TBD 6qd7 U P 0 B | A protein | protein NA | NA envelope glycoprotein | envelope glycoprotein,virion spike glycoprotein,ebov-gp1 VIRAL PROTEIN 01/01/19 EM structure of a EBOV-GP bound to 3T0331 neutralizing antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus | ebola virus Diskin, R., Cohen-Dvashi, H. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7e72 C D 0 F protein NA angiopoietin-1 receptor MEMBRANE PROTEIN 02/25/21 Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kim, H.M., Jo, G.H., Hong, H.J., Han, A. 2.094 X-RAY DIFFRACTION 0.233 0.183 False True IGHV1 IGKV9 Kappa None None None None None 7n64 H L 0 B | A protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/Immune System 06/07/21 SARS-CoV-2 Spike (2P) in complex with G32R7 Fab (RBD and NTD local reconstruction) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Windsor, I.W., Jenni, S., Tong, P., Gautam, A.K., Wesemann, D.R., Harrison, S.C. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6s3d H L 0 P protein s0_2.126 ANTIVIRAL PROTEIN 06/25/19 Structure of D25 Fab in complex with scaffold S0_2.126 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Cramer, J.T., Krey, T. 3.0 X-RAY DIFFRACTION 0.292 0.269 False True IGHV1 IGKV1 Kappa None None None None None 1fig H L 0 H Hapten TSA 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID IMMUNOGLOBULIN 01/07/94 ROUTES TO CATALYSIS: STRUCTURE OF A CATALYTIC ANTIBODY AND COMPARISON WITH ITS NATURAL COUNTERPART MUS MUSCULUS mus musculus mus musculus mus musculus Haynes, M.R., Stura, E.A., Hilvert, D., Wilson, I.A. 3.0 X-RAY DIFFRACTION unknown 0.220 False True IGHV1 IGKV4 Kappa None None None None None 5cjx H L 0 B | G protein | protein NA | NA bg505 env gp41 | bg505 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 Crystal structure of 8ANC195 Fab in complex with BG505 SOSIP.664 HIV-1 Env trimer HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Scharf, L., Bjorkman, P.J. 3.584 X-RAY DIFFRACTION 0.286 0.239 False True unknown IGKV1 Kappa None None None None None 5i66 A B 0 IMMUNE SYSTEM 02/16/16 X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter MUS MUSCULUS mus musculus mus musculus Coleman, J.A., Green, E.M., Gouaux, E. 1.624 X-RAY DIFFRACTION 0.198 0.178 False True IGHV1 IGKV6 Kappa None None None None None 5nyx H L 0 IMMUNE SYSTEM 05/12/17 human Fab fragment 5H2 against NHBA from Neisseria meningitidis HOMO SAPIENS homo sapiens homo sapiens Enrico, M., Maritan, M. 1.88 X-RAY DIFFRACTION 0.226 0.186 False True IGHV4 IGKV1 Kappa None None None None None 5dlm H L 0 X peptide matrix protein 2 IMMUNE SYSTEM 09/07/15 Complex of Influenza M2e and Antibody MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus influenza a virus Cho, K.J., Schepens, B., Moonens, K., Deng, L., Fiers, W., Remaut, H., Saelens, X. 2.2 X-RAY DIFFRACTION 0.240 0.187 False False IGHV5 IGKV1 Kappa None None None None None 2bx5 NA E 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 3ze1 H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 3.0 X-RAY DIFFRACTION 0.2330 0.1749 False True IGHV14 IGKV14 Kappa None None None None None 3u7a NA A 0 IMMUNE SYSTEM 10/13/11 AL-09 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 2.0 X-RAY DIFFRACTION 0.232 0.201 False True IGKV1 Kappa None None None None None 1bvl C D 0 HUMANIZED ANTIBODY 09/16/98 HUMANIZED ANTI-LYSOZYME FV HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Holmes, M.A., Foote, J. 2.87 X-RAY DIFFRACTION unknown 0.220 False True IGHV4 IGKV1 Kappa None None None None None 7rku H L 0 NA NA NA NA VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens Jette, C.A., Bjorkman, P.J., Barnes, C.O. 3.2 X-RAY DIFFRACTION 0.231 0.188 False True IGHV4 IGKV1 Kappa None None None None None 7k65 B NA 0 A protein NA protein patched homolog 1 MEMBRANE PROTEIN 09/18/20 Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23 MUS MUSCULUS; LAMA GLAMA lama glama mus musculus Zhang, Y., Bulkley, D.P., Liang, J., Manglik, A., Cheng, Y., Beachy, P.A. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7n3e H L 0 NA NA NA NA IMMUNE SYSTEM 06/01/21 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C032 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J., Barnes, C.O. 2.06 X-RAY DIFFRACTION 0.228 0.200 False True IGHV5 IGLV1 Lambda None None None None None 4hjj NA L 0 IMMUNE SYSTEM 10/12/12 Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule HOMO SAPIENS homo sapiens Jakob, C.G., Edalji, R., Judge, R.A., DiGiammarino, E., Li, Y., Gu, J., Ghayur, T. 2.1 X-RAY DIFFRACTION 0.220 0.184 False True IGKV3 Kappa 1.6e-10 -13.363971414233674 Unknown TBD 7aql D d 0 NA NA NA NA IMMUNE SYSTEM 10/22/20 Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7) MUS MUSCULUS mus musculus Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 1.8 X-RAY DIFFRACTION 0.223 0.186 True True unknown unknown unknown None None None None None 4aj0 NA B 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of an amyloidogenic variant, 3rCW, of the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.7 X-RAY DIFFRACTION 0.2116 0.1741 False True IGLV3 Lambda None None None None None 7lmq NA A 0 A Hapten 9ZW 4-methyl-3-(morpholin-4-ylmethyl)-7-[(1~{R})-1-phenylethoxy]chromen-2-one IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 62 [4-methyl-3-(morpholinomethyl)-7-(1-phenylethoxy)-2H-chromen-2-one] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.91 X-RAY DIFFRACTION 0.203 0.161 False True NA IGLV6 Lambda None None None None None 4lly A B 0 IMMUNE SYSTEM 07/09/13 Crystal structure of Pertuzumab Clambda Fab with variable and constant domain redesigns (VRD2 and CRD2) at 1.6A HOMO SAPIENS homo sapiens homo sapiens Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S. 1.6 X-RAY DIFFRACTION 0.229 0.198 False True IGHV3 IGKV1 Kappa None None None None None 7kbp A a 0 NA NA NA NA PROTEIN BINDING 10/02/20 Herceptin Diabody with R83T, E85C Mutations HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 2.3 X-RAY DIFFRACTION 0.232 0.184 True True unknown unknown unknown None None None None None 3bkm H L 0 IMMUNE SYSTEM 12/07/07 Structure of anti-amyloid-beta Fab WO2 (Form A, P212121) MUS MUSCULUS mus musculus mus musculus Miles, L.A., Wun, K.S., Crespi, G.A., Fodero-Tavoletti, M., Galatis, D., Bageley, C.J., Beyreuther, K., Masters, C.L., Cappai, R., McKinstry, W.J., Barnham, K.J., Parker, M.W. 1.6 X-RAY DIFFRACTION 0.226 0.203 False False IGHV8 IGKV1 Kappa None None None None None 4ppt A NA 0 IMMUNE SYSTEM 02/27/14 Engineered Dual Specific VHH Antibody in Complex with a Nickel (II) Ion ESCHERICHIA COLI Fanning, S.W., Walter, R., Horn, J.R. 1.5 X-RAY DIFFRACTION 0.224 0.192 False True IGHV1 None None None None None 4kro D C 0 A protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS; LAMA GLAMA mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Ferguson, K.M., Schmitz, K.R. 3.054 X-RAY DIFFRACTION 0.280 0.221 False True IGHV2 IGKV5 Kappa 2.7600000000000004e-07 -8.948201016697006 SPR TBD 4jre B C 0 A protein nitrite extrusion protein 1 TRANSPORT PROTEIN/Immune System 03/21/13 Crystal structure of nitrate/nitrite exchanger NarK with nitrite bound ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Zheng, H., Wisedchaisri, G., Gonen, T. 2.8 X-RAY DIFFRACTION 0.269 0.223 False False IGHV9 IGKV19 Kappa None None None None None 5t3x D E 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 08/26/16 3.9 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gristick, H.B., Bjorkman, P.J. 3.9 X-RAY DIFFRACTION 0.331 0.296 False True IGHV1 IGLV2 Lambda None None None None None 5xjm H L 0 A protein type-2 angiotensin ii receptor,soluble cytochrome b562,type-2 angiotensin ii receptor SIGNALING PROTEIN 05/02/17 Complex structure of angiotensin II type 2 receptor with Fab HOMO SAPIENS; ESCHERICHIA COLI; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens, escherichia coli Asada, H., Horita, S., Shimamura, T., Iwata, S. 3.2 X-RAY DIFFRACTION 0.275 0.226 False True IGHV5 IGKV4 Kappa 4.3e-10 -12.77823529775025 Unknown TBD 7mta H L 2 G protein NA rhodopsin kinase grk1 MEMBRANE, Signaling protein/Immune System 05/13/21 Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Chen, Q., Chen, C.-L., Tesmer, J.J.G. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5jmo D NA 0 B protein furin Hydrolase/Antibody 04/29/16 X-ray structure of a protease-antibody complex CAMELUS DROMEDARIUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT camelus dromedarius homo sapiens Dahms, S.O., Than, M.E. 1.998 X-RAY DIFFRACTION 0.197 0.163 False True IGHV3 None None None None None 7a6c C B 0 A protein NA multidrug resistance protein 1 TRANSPORT PROTEIN 08/25/20 Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and elacridar HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nosol, K., Locher, K.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 5udd J P 0 A protein NA fusion glycoprotein f0 Viral Protein/Immune System 12/26/16 Crystal Structure of RSV F B9320 Bound to MEDI8897 HUMAN RESPIRATORY SYNCYTIAL VIRUS 9320; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus 9320 McLellan, J.S. 4.3 X-RAY DIFFRACTION 0.295 0.237 False True IGHV1 IGKV1 Kappa None None None None None 6x5e B A 0 NA NA NA NA IMMUNE SYSTEM 05/26/20 Crystal structure of a Lewis-binding Fab (ch88.2) MUS MUSCULUS mus musculus mus musculus Soliman, C., Ramsland, P.A. 2.29 X-RAY DIFFRACTION 0.284 0.230 False True IGHV6 IGKV12 Kappa None None None None None 3iy0 H L 0 IMMUNE SYSTEM 04/07/09 Variable domains of the x-ray structure of Fab 14 fitted into the cryoEM reconstruction of the virus-Fab 14 complex MUS MUSCULUS mus musculus mus musculus Hafenstein, S., Bowman, V.D., Sun, T., Nelson, C.D., Palermo, L.M., Chipman, P.R., Battisti, A.J., Parrish, C.R., Rossmann, M.G. 12.5 ELECTRON MICROSCOPY False False IGHV1 IGKV6 Kappa None None None None None 4l1h NA A 0 IMMUNE SYSTEM 06/03/13 Bence-Jones immunoglobulin REI variable portion with seven point mutations HOMO SAPIENS homo sapiens Uson, I. 1.68 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 4m6o H L 0 IMMUNE SYSTEM 08/09/13 Crystal structure of anti-NGF antibody CNTO7309 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.8 X-RAY DIFFRACTION 0.250 0.186 False True IGHV3 IGKV1 Kappa None None None None None 2vyr J NA 0 A protein mdm4 protein IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 6bf9 C D 0 A protein insulin-degrading enzyme HYDROLASE/IMMUNE SYSTEM 10/26/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 7.2 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 5ugy J N 0 E protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/10/17 Influenza hemagglutinin in complex with a neutralizing antibody INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Whittle, J.R.R., Jenni, S., Harrison, S.C. 2.801 X-RAY DIFFRACTION 0.289 0.259 False True IGHV1 IGLV3 Lambda None None None None None 7n65 G H 0 E protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 06/07/21 Complex structure of HIV superinfection Fab QA013.2 and BG505.SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Mangala Prasad, V., Shipley, M.M., Overbaugh, J.M., Lee, K.K. 4.15 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 4xgz H L 0 h peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 7d68 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 BIOSYNTHETIC PROTEIN 09/29/20 Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex BOS TAURUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct bos taurus | bos taurus Sun, W., Chen, L., Zhou, Q., Zhao, L., Zhang, H., Cong, Z., Shen, D., Zhao, F., Zhou, F., Cai, X., Chen, Y., Zhou, Y., Gadgaard, S., van der Velden, W.J., Zhao, S., Jiang, Y., Rosenkilde, M.M., Yang, D., Xu, H.E., Zhang, Y., Wang, M. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5xp1 NA A 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 3zkn C D 0 B protein beta-secretase 2 IMMUNE SYSTEM/HYDROLASE 01/23/13 BACE2 FAB INHIBITOR COMPLEX HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 2.0 X-RAY DIFFRACTION 0.25141 0.20318 False True IGHV2 IGKV3 Kappa None None None None None 5imo B NA 0 A protein protein vsig4 IMMUNE SYSTEM 03/06/16 Nanobody targeting mouse Vsig4 in Spacegroup P3221 CAMELIDAE; MUS MUSCULUS camelidae mus musculus Wen, Y., Zheng, F. 2.1 X-RAY DIFFRACTION 0.281 0.241 False True IGHV1 None None None None None 5dub A B 0 IMMUNE SYSTEM 09/18/15 Context-independent anti-hypusine antibody FabHpu98 in complex with deoxyhypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus Zhai, Q., Carter, P.J. 2.0 X-RAY DIFFRACTION 0.220 0.181 False True IGHV1 IGKV1 Kappa None None None None None 6mtt H L 0 P peptide rv217 founder virus gp41 peptide IMMUNE SYSTEM 10/21/18 Crystal structure of VRC46.01 Fab in complex with gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Druz, A., Law, W.H., Peng, D., Veradi, R., Doria-Rose, N.A., Kwong, P.D. 1.7 X-RAY DIFFRACTION 0.265 0.235 False True IGHV1 IGKV1 Kappa None None None None None 7qn7 F NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 HOMO SAPIENS homo sapiens homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7eow B NA 0 A protein NA von willebrand factor STRUCTURAL PROTEIN 04/23/21 High-resolution structure of vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine HOMO SAPIENS homo sapiens homo sapiens Lee, H.T., Heo, Y.-S. 1.6 X-RAY DIFFRACTION 0.198 0.175 False True IGHV3 NA NA None None None None None 1bbd H L 0 IMMUNOGLOBULIN 05/05/92 THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2 MUS MUSCULUS mus musculus Tormo, J., Blaas, D., Fita, I. 2.8 X-RAY DIFFRACTION unknown unknown False True IGHV14 IGKV8 Kappa None None None None None 6uyf H L 0 E protein envelope glycoprotein e2 VIRAL PROEIN/IMMUNE SYSTEM 11/13/19 Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 6a bound to broadly neutralizing antibody AR3B HOMO SAPIENS; RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Zhu, J. 2.06 X-RAY DIFFRACTION 0.232 0.189 False True IGHV1 IGKV3 Kappa None None None None None 5vta H L 0 D protein dipeptidyl peptidase 4 HYDROLASE 05/16/17 Co-Crystal Structure of DPPIV with a Chemibody Inhibitor RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Johnstone, S., Cheng, A. 2.8 X-RAY DIFFRACTION 0.300 0.250 False True IGHV1 IGKV4 Kappa None None None None None 7ah1 A a 0 NA NA NA NA IMMUNE SYSTEM 09/23/20 L19 diabody fragment from immunocytokine L19-IL2 HOMO SAPIENS homo sapiens Ongaro, T., Guarino, S.R., Scietti, L., Palamini, M., Wulhfard, S., Villa, A., Neri, D., Forneris, F. 2.0 X-RAY DIFFRACTION 0.220 0.198 True True unknown unknown unknown None None None None None 7u0c C D 0 NA NA NA NA ANTIVIRAL PROTEIN,IMMUNE SYSTEM 02/17/22 Crystal structure of broadly neutralizing antibody HEPC3.4 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 3.3 X-RAY DIFFRACTION 0.260 0.215 False True IGHV1 IGKV1 Kappa None None None None None 7kzz D C 0 A protein NA cadmium and zinc efflux pump fief MEMBRANE PROTEIN 12/10/20 Cryo-EM structure of YiiP-Fab complex in Holo state SHEWANELLA ONEIDENSIS; HOMO SAPIENS homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Fan, S., Koide, A., Koide, S., Beckstein, O., Stokes, D.L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2qtj C O 9 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7nfq C NA 0 A protein NA polymerase basic protein 2 VIRAL PROTEIN 02/07/21 Fujian capmidlink domain in complex with Nb8193 INFLUENZA A VIRUS (A/DUCK/FUJIAN/13/2002(H5N1)); CAMELIDAE MIXED LIBRARY camelidae mixed library influenza a virus (a/duck/fujian/13/2002(h5n1)) Keown, J.R., Grimes, J.M., Fodor, E. 1.68 X-RAY DIFFRACTION 0.205 0.167 False True IGHV3 NA NA None None None None None 5esq D C 0 IMMUNE SYSTEM 11/16/15 Cetuximab Fab in complex with cyclic beta-alanine-linked meditope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Bzymek, K.P., Williams, J.C. 2.55 X-RAY DIFFRACTION 0.242 0.190 False True IGHV2 IGKV5 Kappa 1.6000000000000001e-06 -7.906995056592657 Unknown TBD 5gkr C D 0 IMMUNE SYSTEM/DNA 07/05/16 Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Arimori, T., Sakakibara, S., Kikutani, H., Takagi, J. 2.1 X-RAY DIFFRACTION 0.185 0.163 False True IGHV4 IGLV2 Lambda 4.6100000000000004e-09 -11.372746740093346 Unknown TBD 3if1 B A 0 IMMUNE SYSTEM 07/23/09 Crystal structure of 237mAb in complex with a GalNAc MUS MUSCULUS mus musculus mus musculus Brooks, C.L., Evans, S.V., Borisova, S.N. 2.39 X-RAY DIFFRACTION 0.285 0.224 False True IGHV6 IGKV1 Kappa None None None None None 4fp8 H L 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/21/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.947 X-RAY DIFFRACTION 0.241 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6q6z B NA 0 A protein protein eds1l IMMUNE SYSTEM 12/12/18 Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB21 ARABIDOPSIS THALIANA; LAMA GLAMA lama glama arabidopsis thaliana Niefind, K., Voss, M., Toelzer, C. 3.476 X-RAY DIFFRACTION 0.268 0.219 False True IGHV1 None None None None None 3nn8 C F 0 IMMUNE SYSTEM 06/23/10 Crystal structure of engineered antibody fragment based on 3D5 MUS MUSCULUS mus musculus mus musculus Lieberman, R.L., Maynard, J.A., Drury, J.E., Pai, J., Culver, J.A. 3.1 X-RAY DIFFRACTION 0.238 0.183 True True IGHV1 IGKV1 Kappa None None None None None 1nd0 H G 0 G Hapten DP4 (1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE 1-OXIDE IMMUNE SYSTEM 12/05/02 CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.286 0.242 False False IGHV3 IGKV1 Kappa None None None None None 7lop H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/10/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.246 X-RAY DIFFRACTION 0.268 0.220 False True IGHV1 IGKV3 Kappa None None None None None 4xbp A B 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylethanolamine (06:0 PE) HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.94 X-RAY DIFFRACTION 0.271 0.228 False True IGHV1 IGKV3 Kappa None None None None None 4xgz W X 0 w peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 5xaj H L 0 IMMUNE SYSTEM 03/13/17 Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex. DENGUE VIRUS dengue virus dengue virus Wong, Y.H., Goh, B.C., Lescar, J. 2.5 X-RAY DIFFRACTION 0.239 0.185 False True IGHV3 IGKV3 Kappa None None None None None 6sc9 B NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-HOIPIN-8 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.47 X-RAY DIFFRACTION 0.252 0.210 False True IGHV3 None None None None None 6w0f A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Closed-gate KcsA soaked in 0mM KCl/5mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 2.4 X-RAY DIFFRACTION 0.270 0.244 False True IGHV1 IGKV5 Kappa None None None None None 6m3c F E 0 C protein NA vitamin k-dependent protein c heavy chain BLOOD CLOTTING/IMMUNE SYSTEM 03/03/20 hAPC-h1573 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, X., Wang, D., Zhao, X., Egner, U. 3.7 X-RAY DIFFRACTION 0.302 0.278 False True IGHV3 IGKV3 Kappa None None None None None 6axl A B 0 I peptide peptide ace-asn-pro-asn-ala-asn-pro-asn-ala-asn-pro-asn-ala-nh2 IMMUNE SYSTEM 09/07/17 Crystal structure of Fab317 complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Oyen, D., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.217 0.175 False True IGHV3 IGKV1 Kappa 7.8e-08 -9.696917926366758 Unknown TBD 1yc8 A NA 0 IMMUNE SYSTEM 12/22/04 cAbAn33- Y37V/E44G/R45L triple mutant CAMELUS DROMEDARIUS camelus dromedarius Conrath, K., Vincke, C., Stijlemans, B., Schymkowitz, J., Wyns, L., Muyldermans, S., Loris, R. 2.7 X-RAY DIFFRACTION 0.324 0.246 False True IGHV1 None None None None None 4otx H L 0 immune system 02/14/14 Structure of the anti-Francisella tularensis O-antigen antibody N203 Fab fragment MUS MUSCULUS mus musculus mus musculus Lu, Z., Rynkiewicz, M.J., Yang, C.-Y., Madico, G., Perkins, H.M., Roche, M.I., Seaton, B.A., Sharon, J. 2.1 X-RAY DIFFRACTION 0.228 0.193 False False IGHV1 IGKV8 Kappa None None None None None 7km6 h l 0 NA NA NA NA IMMUNE SYSTEM 11/02/20 APOBEC3B antibody 5G7 Fv-clasp HOMO SAPIENS homo sapiens homo sapiens Tang, H., Shi, K., Aihara, H. 1.67 X-RAY DIFFRACTION 0.238 0.189 False False IGHV5 IGKV8 Kappa None None None None None 4zyk A B 0 IMMUNE SYSTEM 05/21/15 Crystal Structure of Quaternary-Specific RSV-Neutralizing Human Antibody AM14 HOMO SAPIENS homo sapiens homo sapiens Gilman, M.S.A., McLellan, J.S. 2.0 X-RAY DIFFRACTION 0.226 0.186 False True IGHV3 IGKV1 Kappa None None None None None 4lly C D 0 IMMUNE SYSTEM 07/09/13 Crystal structure of Pertuzumab Clambda Fab with variable and constant domain redesigns (VRD2 and CRD2) at 1.6A HOMO SAPIENS homo sapiens homo sapiens Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S. 1.6 X-RAY DIFFRACTION 0.229 0.198 False True IGHV3 IGKV1 Kappa None None None None None 2kqm NA B 17 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 3cfi C NA 0 B protein type ii secretory pathway, pseudopilin epsj PROTEIN TRANSPORT/Immune system 03/03/08 Nanobody-aided structure determination of the EPSI:EPSJ pseudopilin heterdimer from Vibrio Vulnificus VIBRIO VULNIFICUS; LAMA GLAMA lama glama vibrio vulnificus Lam, A.Y., Pardon, E., Korotkov, K.V., Steyaert, J., Hol, W.G.J. 2.58 X-RAY DIFFRACTION 0.279 0.229 False True IGHV3 None None None None None 7fjn H L 0 B protein NA spike glycoprotein,envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/04/21 Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, human immunodeficiency virus 1 Wang, X., Zhang, L., Zhang, S., Liang, Q. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7v2a I H 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/07/21 SARS-CoV-2 Spike trimer in complex with XG014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, K., Wang, X., Pan, L. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 7f5g D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 06/22/21 The crystal structure of RBD-Nanobody complex, DL4 (SA4) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Li, T., Lai, Y., Zhou, Y., Tan, J., Li, D. 1.75 X-RAY DIFFRACTION 0.217 0.188 False True IGHV1 NA NA None None None None None 2kh2 B b 17 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5o2u B NA 0 A protein capsid protein p24 VIRUS 05/22/17 Llama VHH in complex with p24 LAMA GLAMA; HUMAN IMMUNODEFICIENCY VIRUS 1 lama glama human immunodeficiency virus 1 Caillat, C., Verrips, T., Weissenhorn, W. 2.76 X-RAY DIFFRACTION 0.256 0.222 False True IGHV1 6.9e-10 -12.498045980157077 SPR TBD 6wio A B 0 C protein NA interleukin-17a CYTOKINE/IMMUNE SYSTEM 04/10/20 Fab antigen complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Antonysamy, S. 2.17 X-RAY DIFFRACTION 0.227 0.208 False True IGHV3 IGKV3 Kappa None None None None None 7lo6 H G 0 E protein NA envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/09/21 Structure of CD4 mimetic BNM-III-170 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Jette, C.A., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6mtp A B 0 Q peptide rv217 founder virus gp41 peptide IMMUNE SYSTEM 10/21/18 Crystal structure of VRC42.04 Fab in complex with gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Druz, A., Law, W.H., Peng, D., Zhang, B., Doria-Rose, N.A., Kwong, P.D. 2.036 X-RAY DIFFRACTION 0.223 0.199 False True IGHV1 IGKV3 Kappa None None None None None 6x3w K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.3 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 6xcn B D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/08/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6x98 K J 0 G protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11B fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.38 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7r63 D NA 0 NA NA NA NA IMMUNE SYSTEM 06/22/21 Nb82, a nanobody against voltage gated sodium channels Nav1.4 and Nav1.5 LAMA GLAMA lama glama Srinivasan, L., Gabelli, S.B. 2.0 X-RAY DIFFRACTION 0.244 0.184 False True IGHV1 NA NA None None None None None 6hjx F NA 0 A protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.5 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 None None None None None 5hys H L 0 I protein ig epsilon chain c region IMMUNE SYSTEM 02/01/16 Structure of IgE complexed with omalizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Tarchevskaya, S.S., Sathiyamoorthy, K., Jardetzky, T.S. 2.5 X-RAY DIFFRACTION 0.239 0.221 False True IGHV3 IGKV1 Kappa 3.8899999999999996e-11 -14.201849726854265 SPR TBD 6xsw G I 0 J protein NA neurogenic locus notch homolog protein 3 SIGNALING PROTEIN/Immune System 07/16/20 Structure of the Notch3 NRR in complex with an antibody Fab Fragment RATTUS NORVEGICUS; HOMO SAPIENS rattus norvegicus rattus norvegicus homo sapiens Bard, J. 2.98 X-RAY DIFFRACTION 0.256 0.233 False True IGHV3 IGKV1 Kappa None None None None None 6oc8 B NA 0 IMMUNE SYSTEM 03/22/19 Crystal structure of a VHH against the capsid protein from BLV LAMA GLAMA lama glama Carrion, F., Larrieux, N., Trajtenberg, F., Buschiazzo, A. 2.109 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 None None None None None 1cl7 H L 0 IMMUNE SYSTEM 05/06/99 ANTI HIV1 PROTEASE FAB MUS MUSCULUS mus musculus mus musculus Lescar, J., Bentley, G.A. 3.0 X-RAY DIFFRACTION 0.280 0.183 False False IGHV9 IGKV1 Kappa None None None None None 6x1t J K 0 P peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 2.34 X-RAY DIFFRACTION 0.269 0.244 False True IGHV1 IGKV1 Kappa None None None None None 6pzz H L 0 A protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6y9b H L 0 C protein metalloreductase steap1 MEMBRANE PROTEIN 05/20/20 Cryo-EM structure of trimeric human STEAP1 bound to three Fab120.545 fragments HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Oosterheert, W., Gros, P. 2.97 ELECTRON MICROSCOPY False True IGHV3 IGKV8 Kappa None None None None None 6vyv L P 0 H protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/27/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain ROSS RIVER VIRUS (STRAIN T48); HOMO SAPIENS homo sapiens homo sapiens ross river virus (strain t48) Miller, A.S., Kuhn, R.J. 6.33 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 2rcj E H 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 7s7r B NA 0 A protein NA merozoite surface protein p12 UNKNOWN FUNCTION 09/17/21 Plasmodium falciparum protein Pf12 bound to nanobody G7 PLASMODIUM FALCIPARUM 3D7; VICUGNA PACOS vicugna pacos plasmodium falciparum 3d7 Dietrich, M.H., Tham, W.H. 1.77 X-RAY DIFFRACTION 0.255 0.221 False True IGHV1 NA NA None None None None None 6k2i A NA 5 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 5vzr H L 0 IMMUNE SYSTEM 05/29/17 Crystal Structure of MERS-CoV neutralizing antibody G4 Fab MUS MUSCULUS mus musculus mus musculus Wang, N., Wrapp, D., McLellan, J.S. 1.57 X-RAY DIFFRACTION 0.215 0.182 False True IGHV1 IGKV3 Kappa None None None None None 3qxw E NA 0 IMMUNE SYSTEM 03/02/11 Free structure of an anti-methotrexate CDR1-4 Graft VHH Antibody LAMA GLAMA lama glama Fanning, S.W., Horn, J.R. 1.85 X-RAY DIFFRACTION 0.238 0.189 False True IGHV1 None None None None None 7shz K L 0 H protein NA ige fc IMMUNE SYSTEM 10/11/21 IgE-Fc in complex with HAE HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.J., Kleinboelting, S. 3.0 X-RAY DIFFRACTION 0.236 0.186 False True IGHV3 IGKV1 Kappa None None None None None 6s5a H L 0 D | A protein | protein NA | NA fc p329g lala | fc p329g lala IMMUNE SYSTEM 07/01/19 CRYSTAL STRUCTURE OF FC P329G LALA WITH ANTI FC P329G FAB HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Ehler, A., Darowski, D., Jost, C., Stubenrauch, K., Wessels, U., Benz, J., Birk, M., Freimoser-Grundschober, A., Bruenker, P., Moessner, E., Umana, P., Kobold, S., Klein, C. 1.72 X-RAY DIFFRACTION 0.226 0.196 False True IGHV4 IGLV1 Lambda None None None None None 7p60 I NA 0 F protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb4 at 1:0.5 ratio MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7l09 M K 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/11/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound domain-swapped antibody 2G12 from masked 3D refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Henderson, R., Acharya, P. 3.1 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7t0j B A 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.15 X-RAY DIFFRACTION 0.281 0.230 False True IGHV7 IGKV8 Kappa None None None None None 6ikm N n 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 7f35 B A 0 A Hapten GFN 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid IMMUNE SYSTEM 06/15/21 Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with S-gatifloxacin MUS MUSCULUS mus musculus mus musculus mus musculus Wang, L.T., Jiao, W.Y., Shen, X., Lei, H.T. 2.6 X-RAY DIFFRACTION 0.235 0.200 False False IGHV1 IGKV3 Kappa None None None None None 1otu C D 0 A protein voltage-gated clc-type chloride channel eric MEMBRANE PROTEIN 03/23/03 Structure of the Escherichia coli ClC Chloride channel E148Q mutant and Fab Complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Dutzler, R., Campbell, E.B., MacKinnon, R. 3.3 X-RAY DIFFRACTION 0.325 0.294 False False IGHV4 IGKV4 Kappa None None None None None 2zuq F E 0 D protein disulfide bond formation protein b Oxidoreductase/IMMUNE SYSTEM 10/28/08 Crystal structure of DsbB-Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Inaba, K., Suzuki, M., Murakami, S. 3.3 X-RAY DIFFRACTION 0.351 0.275 False False IGHV5 IGKV8 Kappa None None None None None 6rnn D C 0 IMMUNE SYSTEM 05/09/19 P46, an immunodominant surface protein from Mycoplasma hyopneumoniae MUS MUSCULUS mus musculus mus musculus Guasch, A., Fita, I. 1.735 X-RAY DIFFRACTION 0.256 0.222 False True IGHV3 IGKV3 Kappa None None None None None 7lq7 C D 0 B protein NA spike protein s1 IMMUNE SYSTEM 02/13/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 IGLV2 Lambda None None None None None 7c2l I M 0 B protein NA spike glycoprotein MEMBRANE PROTEIN/IMMUNE SYSTEM 05/08/20 S protein of SARS-CoV-2 in complex bound with 4A8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Guo, Y.Y., Li, Y.N., Xia, L., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 7aqy C NA 0 B protein NA variant surface glycoprotein mitat 1.2 MEMBRANE PROTEIN 10/23/20 Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB11) LAMA GLAMA; TRYPANOSOMA BRUCEI BRUCEI lama glama trypanosoma brucei brucei Stebbins, C.E., Hempelmann, A., VanStraaten, M. 1.9 X-RAY DIFFRACTION 0.242 0.209 False True IGHV1 NA NA None None None None None 5uk4 k NA 0 K protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 4oga C D 0 E protein insulin receptor domains l1-cr HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM 01/15/14 Insulin in complex with Site 1 of the human insulin receptor HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G. 3.5 X-RAY DIFFRACTION 0.284 0.264 False True IGHV2 IGKV8 Kappa None None None None None 6uht D NA 0 B protein botulinum neurotoxin type b TOXIN/ANTITOXIN 09/28/19 Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.20001 X-RAY DIFFRACTION 0.211 0.194 False True IGHV1 None None None None None 1xf5 D C 0 Q peptide capsid protein c IMMUNE SYSTEM 09/14/04 Complex HCV core-Fab 19D9D6-Protein L mutant (H74C, Y64W)in space group P21212 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 2.6 X-RAY DIFFRACTION 0.240 0.199 False False IGHV9 IGKV8 Kappa None None None None None 6o2b H I 0 K peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein DND and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.1 X-RAY DIFFRACTION 0.210 0.177 False True IGHV3 IGKV3 Kappa None None None None None 5cjo H L 0 A protein insulin HYDROLASE/HYDROLASE INHIBITOR 07/14/15 Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens liang, w.g., bailey, L., tang, w.j. 3.287 X-RAY DIFFRACTION 0.245 0.196 False True IGHV3 IGKV1 Kappa None None None None None 2mkw NA A 6 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6itc C NA 0 G | A protein | protein NA | NA green fluorescent protein | protein translocase subunit seca PROTEIN TRANSPORT 11/21/18 Structure of a substrate engaged SecA-SecY protein translocation machine BACILLUS SUBTILIS (STRAIN 168); GEOBACILLUS THERMODENITRIFICANS (STRAIN NG80-2); LAMA GLAMA; ESCHERICHIA COLI; AEQUOREA VICTORIA lama glama aequorea victoria | bacillus subtilis (strain 168) Ma, C.Y., Wu, X.F., Sun, D.J., Park, E.Y., Rapoport, T.A., Gao, N., Long, L. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4x80 H L 0 IMMUNE SYSTEM 12/09/14 Crystal Structure of murine 7B4 Fab monoclonal antibody against ADAMTS5 MUS MUSCULUS mus musculus mus musculus Larkin, J., Lohr, T.A., Elefante, L., Shearin, J., Matico, R., Su, J.-L., Xue, Y., Liu, F., Genell, C., Miller, R.E., Tran, P.B., Malfait, A.-M., Maier, C.C., Matheny, C.J. 2.6 X-RAY DIFFRACTION 0.282 0.218 False True IGHV6 IGKV12 Kappa None None None None None 6ztr A B 0 J protein NA cadherin-3 IMMUNE SYSTEM 07/20/20 Crystal Structure of the anti-human P-Cadherin Fab CQY684 in complex with human P-Cadherin(108-324) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rondeau, J.M., Lehmann, S. 2.1 X-RAY DIFFRACTION 0.221 0.192 False True IGHV6 IGKV1 Kappa None None None None None 7sp8 C NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2; LAMA GLAMA lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6vbq A B 0 I peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH822 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.116 X-RAY DIFFRACTION 0.211 0.181 False True IGHV1 IGLV3 Lambda None None None None None 5m14 D NA 0 IMMUNE SYSTEM 10/07/16 Synthetic nanobody in complex with MBP ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct Zimmermann, I., Egloff, P., Seeger, M.A. 1.6 X-RAY DIFFRACTION 0.216 0.190 False True IGHV1 None None None None None 6c5i H L 0 SUGAR BINDING PROTEIN 01/16/18 Unliganded S25-5 Fab MUS MUSCULUS mus musculus mus musculus Evans, S.V., Haji-Ghassemi, O. 1.89 X-RAY DIFFRACTION 0.231 0.193 False False IGHV2 IGKV1 Kappa None None None None None 1ua6 H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 02/28/03 Crystal structure of HYHEL-10 FV MUTANT SFSF complexed with HEN EGG WHITE LYSOZYME complex MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Kumagai, I., Nishimiya, Y., Kondo, H., Tsumoto, K. 1.9 X-RAY DIFFRACTION 0.265 0.227 False True IGHV3 IGKV5 Kappa None None None None None 2dwe A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 08/10/06 Crystal structure of KcsA-FAB-TBA complex in Rb+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Yohannan, S., Zhou, Y. 2.5 X-RAY DIFFRACTION 0.266 0.230 False False IGHV1 IGKV5 Kappa None None None None None 2kh2 B b 38 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5yup H L 0 IMMUNE SYSTEM 11/22/17 Crystal Structure of the Fab fragment of FVIIa antibody mAb4F5 MUS MUSCULUS mus musculus mus musculus Jiang, L.G., Persson, E., Huang, M.D. 1.81 X-RAY DIFFRACTION 0.249 0.207 False False IGHV5 IGKV6 Kappa None None None None None 1ivl NA B 0 IMMUNOGLOBULIN 05/04/94 THE DE NOVO DESIGN OF AN ANTIBODY COMBINING SITE: CRYSTALLOGRAPHIC ANALYSIS OF THE VL DOMAIN CONFIRMS THE STRUCTURAL MODEL SYNTHETIC CONSTRUCT synthetic construct Essen, L.-O., Skerra, A. 2.17 X-RAY DIFFRACTION unknown 0.175 False True IGKV6D Kappa None None None None None 6itq A NA 0 A Hapten HCY (11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE IMMUNE SYSTEM 11/24/18 Crystal structure of cortisol complexed with its nanobody at pH 10.5 CAMELUS BACTRIANUS camelus bactrianus camelus bactrianus Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. 1.526 X-RAY DIFFRACTION 0.256 0.223 False True unknown unknown unknown None None None None None 6osy M N 0 K protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 7kgv D F 0 A protein NA sodium-coupled neutral amino acid transporter 9 TRANSPORT PROTEIN 10/19/20 Crystal structure of sodium-coupled neutral amino acid transporter SLC38A9 in the N-terminal plugged form DANIO RERIO; MUS MUSCULUS mus musculus mus musculus danio rerio Lei, H., Mu, X., Hattne, J., Gonen, T. 3.4 X-RAY DIFFRACTION 0.284 0.251 False False unknown unknown unknown None None None None None 3v4p H L 0 B | A protein | protein NA | NA integrin beta-7 | integrin alpha-4 CELL ADHESION 12/15/11 crystal structure of a4b7 headpiece complexed with Fab ACT-1 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Yu, Y., Zhu, J., Springer, T.A. 3.15 X-RAY DIFFRACTION 0.251 0.220 False True IGHV1 IGKV1 Kappa None None None None None 4cni H L 0 C protein interleukin-6 01/22/14 Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A. 2.2 X-RAY DIFFRACTION 0.21549 0.17608 False True IGHV3 IGKV1 Kappa 1e-11 -15.006684983512798 SPR TBD 6h0e H L 0 I peptide microtubule-associated protein tau IMMUNE SYSTEM 07/09/18 FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens mus musculus Juraszek, J., Steinbacher, S. 1.95 X-RAY DIFFRACTION 0.285 0.222 False True IGHV1 IGKV2 Kappa 2.4000000000000003e-07 -9.031007686639388 Unknown TBD 7w56 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/21 Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex HOMO SAPIENS; HOMO HEIDELBERGENSIS homo sapiens homo sapiens | homo sapiens You, C., Xu, H.E., Jiang, Y. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4kk9 E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 2mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.997 X-RAY DIFFRACTION 0.270 0.217 False True IGHV4 IGKV4 Kappa None None None None None 4o5l H L 0 immune system 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 HOMO SAPIENS homo sapiens homo sapiens Lee, P.S., Wilson, I.A. 1.5045 X-RAY DIFFRACTION 0.207 0.174 False True IGHV1 IGLV1 Lambda None None None None None 4yxl H L 0 A protein major prion protein IMMUNE SYSTEM 03/23/15 Crystal structure of Syrian hamster prion protein complexed with POM1 FAB MUS MUSCULUS; MESOCRICETUS AURATUS mus musculus mus musculus mesocricetus auratus Baral, P.K., Swayampakula, M., James, M.N.G. 2.604 X-RAY DIFFRACTION 0.310 0.262 False True IGHV1 IGKV5 Kappa None None None None None 4n9g E F 0 D peptide epitope scaffold rsv_1isea_ffl_001_c IMMUNE SYSTEM 10/21/13 Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9 MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta synthetic construct Carrico, C.T.D., Strong, R.K. 2.5 X-RAY DIFFRACTION 0.295 0.263 False True IGHV4 IGKV1 Kappa 3.26e-10 -12.942286816628542 Unknown TBD 4f37 H L 0 A protein colicin-e7 immunity protein IMMUNE SYSTEM 05/09/12 Structure of the tethered N-terminus of Alzheimer's disease A peptide MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Nisbet, R.M., Nuttall, S.D., Caine, J.M., Rober, R., Hittaki, M., Pearce, L.A., Davydova, N., Masters, C.L., Varghese, J.N., Streltsov, V.A. 2.57 X-RAY DIFFRACTION 0.269 0.223 False True IGHV8 IGKV1 Kappa 5.5000000000000004e-09 -11.268161381529886 SPR TBD 6xux A NA 0 NA NA NA NA STRUCTURAL PROTEIN 01/21/20 Crystal structure of Megabody Mb-Nb207-cYgjK_NO ESCHERICHIA COLI K-12 escherichia coli k-12 Steyaert, J., Uchanski, T., Fischer, B. 1.90001 X-RAY DIFFRACTION 0.230 0.189 False True IGHV1 NA NA None None None None None 3mnz B A 0 P peptide gp41 mper-derived peptide IMMUNE SYSTEM 04/22/10 Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide bearing Ala substitutions in a helical conformation MUS MUSCULUS,HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus,homo sapiens mus musculus,homo sapiens Nicely, N.I., Dennison, S.M., Kelsoe, G., Liao, H.-X., Alam, S.M., Haynes, B.F. 1.8 X-RAY DIFFRACTION 0.215 0.179 False True IGHV9 IGKV8 Kappa None None None None None 6x87 K L 0 X protein NA circumsporozoite protein IMMUNE SYSTEM 06/01/20 CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Kucharska, I., Thai, E., Rubinstein, J., Julien, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7tyw N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/14/22 Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1ott E F 0 B protein voltage-gated clc-type chloride channel eric MEMBRANE PROTEIN 03/23/03 Structure of the Escherichia coli ClC Chloride channel E148A mutant and Fab Complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Dutzler, R., Campbell, E.B., MacKinnon, R. 3.0 X-RAY DIFFRACTION 0.338 0.296 False False IGHV4 IGKV4 Kappa None None None None None 7f5h C NA 0 A protein NA sars-cov-2 spike receptor-binding domain (rbd) VIRAL PROTEIN 06/22/21 The crystal structure of RBD-Nanobody complex, DL28 (SC4) Severe acute respiratory syndrome coronavirus 2; Vicugna pacos vicugna pacos severe acute respiratory syndrome coronavirus2 Luo, Z.P., Li, T., Lai, Y., Zhou, Y., Tan, J., Li, D. 3 X-RAY DIFFRACTION 0.248 0.226 False True IGHV1 NA NA None None None None None 5gs1 G g 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 7lmp NA B 0 B Hapten NY6 3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-8-(1~{H}-imidazol-5-ylcarbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 36 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-8-(1H-imidazole-4-carbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.29 X-RAY DIFFRACTION 0.264 0.203 False True NA IGLV6 Lambda None None None None None 5ngv H L 0 A protein activin receptor type-2b TRANSFERASE 03/20/17 CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM HOMO SAPIENS homo sapiens homo sapiens homo sapiens RONDEAU, J.-M., LEHMANN, S. 2.0 X-RAY DIFFRACTION 0.198 0.177 False True IGHV1 IGLV2 Lambda 1.6e-11 -14.728215503643927 Unknown TBD 7p14 B NA 0 A protein NA xk-related protein MEMBRANE PROTEIN 07/01/21 Structure of full-length rXKR9 in complex with a sybody at 3.66A RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT synthetic construct rattus norvegicus Straub, M.S., Sawicka, M., Dutzler, R. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3o41 H L 0 P peptide fusion glycoprotein f1 IMMUNE SYSTEM/VIRAL PROTEIN 07/26/10 Crystal Structure of 101F Fab Bound to 15-mer Peptide Epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human respiratory syncytial virus a McLellan, J.S., Chen, M., Chang, J.S., Yang, Y., Kim, A., Graham, B.S., Kwong, P.D. 1.95 X-RAY DIFFRACTION 0.217 0.177 False True IGHV8 IGKV3 Kappa None None None None None 5kg9 H L 0 IMMUNE SYSTEM 06/13/16 Crystal structure of the gp120 v2 antibody RE505-22 Fab from IGH- and IGK-humanized mouse MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Nicely, N.I. 2.3 X-RAY DIFFRACTION 0.281 0.240 False True IGHV3 IGLV3 Lambda None None None None None 7cbp R S 0 N protein NA envelope protein e VIRUS 06/13/20 CryoEM structure of Zika virus with Fab at 4.1 Angstrom HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Tyagi, A., Ahmed, T., Shi, J., Bhushan, S. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4qhn A B 0 IMMUNE SYSTEM 05/28/14 I2 (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.0 X-RAY DIFFRACTION 0.272 0.226 False True IGHV4 IGLV3 Lambda None None None None None 1ri8 A NA 0 B protein lysozyme c IMMUNE SYSTEM/HYDROLASE 11/17/03 Crystal Structure of the Camelid Single Domain Antibody 1D2L19 in complex with Hen Egg White Lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus De Genst, E., Silence, K., Ghahroudi, M.A., Decanniere, K., Loris, R., Kinne, J., Wyns, L., Muyldermans, S. 1.85 X-RAY DIFFRACTION 0.196 0.173 False True IGHV1 2.90e-09 -11.64 SPR 15659390 12e8 P M 0 NA NA NA NA IMMUNOGLOBULIN 03/14/98 2E8 FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus Rupp, B., Trakhanov, S. 1.9 X-RAY DIFFRACTION 0.271 0.221 False False IGHV14 IGKV6 Kappa None None None None None 7a0v D NA 0 C protein NA synaptojanin-1 HYDROLASE 08/11/20 Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Paesmans, J., Galicia, C., Martin, E., Versees, W. 2.3 X-RAY DIFFRACTION 0.252 0.196 False True IGHV1 NA NA None None None None None 5kov E e 0 B protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 2vyr L NA 0 IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 6b5p H L 0 A peptide pfcsp peptide 20asp IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 20 with human antibody CIS42 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 2.297 X-RAY DIFFRACTION 0.268 0.237 False True IGHV7 IGLV2 Lambda None None None None None 4amk H L 0 IMMUNE SYSTEM 03/12/12 Fab fragment of antiporphrin antibody 13g10 MUS MUSCULUS mus musculus mus musculus Mahy, J.P., Golinelli-Pimpaneau, B. 2.05 X-RAY DIFFRACTION 0.2751 0.2244 False False IGHV1 IGLV1 Lambda None None None None None 5h35 F G 0 E protein membrane protein tric IMMUNE SYSTEM/MEMBRANE PROTEIN 10/20/16 Crystal structures of the TRIC trimeric intracellular cation channel orthologue from Sulfolobus solfataricus SULFOLOBUS SOLFATARICUS; MUS MUSCULUS mus musculus mus musculus sulfolobus solfataricus Kasuya, G., Hiraizumi, M., Hattori, M., Nureki, O. 2.642 X-RAY DIFFRACTION 0.252 0.211 False True IGHV5 IGKV1 Kappa None None None None None 3egs B A 0 C peptide gp41 scrfp-mper construct IMMUNE SYSTEM 09/11/08 Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 scrambledFP-MPER scrHyb3K construct GIGAFGLLGFLAAGSKK-Ahx-K656NEQELLELDKWASLWN671 soaked in ammonium sulfate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., de la Torre, B.G., Andreu, D., Nieva, J.L., Pai, E.F. 3.6 X-RAY DIFFRACTION 0.249 0.235 False False IGHV2 IGKV1 Kappa None None None None None 6hx4 I M 0 A protein alpha-1-antitrypsin PROTEIN BINDING 10/15/18 Fab fragment of a native monomer-selective antibody in complex with alpha-1-antitrypsin HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Elliston, E.L.K., Miranda, E., Perez, J., Jagger, A.M., Lomas, D.A., Irving, J.A. 2.95 X-RAY DIFFRACTION 0.277 0.231 False False IGHV5 IGKV3 Kappa None None None None None 6c6y A B 0 S protein spike glycoprotein IMMUNE SYSTEM 01/19/18 Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain MACACA MULATTA; BETACORONAVIRUS ENGLAND 1 macaca mulatta macaca mulatta betacoronavirus england 1 Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 3.32 X-RAY DIFFRACTION 0.267 0.232 False True IGHV4 IGKV1 Kappa None None None None None 5mhs N G 0 NA NA NA NA IMMUNE SYSTEM 11/25/16 T1L reovirus sigma1 complexed with 5C6 Fab fragments REOVIRUS TYPE 1 (STRAIN LANG); MUS MUSCULUS mus musculus mus musculus Stehle, T., Dietrich, M.H. 3.7 X-RAY DIFFRACTION 0.278 0.261 False False IGHV2 IGKV3 Kappa None None None None None 5d7s H L 0 IMMUNE SYSTEM 08/14/15 Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M. 1.88 X-RAY DIFFRACTION 0.254 0.213 False True IGHV3 IGLV3 Lambda None None None None None 5tpp H L 0 IMMUNE SYSTEM 10/20/16 Crystal Structure of DH270.5 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 1.85 X-RAY DIFFRACTION 0.212 0.179 False True IGHV1 IGLV2 Lambda None None None None None 6u8c D C 0 IMMUNE SYSTEM 09/04/19 Crystal structure of an engineered ultra-high affinity Fab-Protein G complex STREPTOCOCCUS SP. 'GROUP G'; HOMO SAPIENS homo sapiens homo sapiens Slezak, T., Filippova, E.V., Davydova, E.K., Kossiakoff, A.A. 2.61 X-RAY DIFFRACTION 0.250 0.192 False True IGHV3 IGKV1 Kappa None None None None None 5wb9 H L 0 G protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN 06/28/17 Crystal structure of CD4 binding site antibody N60P23 in complex with HIV-1 clade A/E strain 93TH057 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gohain, N., Tolbert, W., Pazgier, M. 2.4 X-RAY DIFFRACTION 0.258 0.213 False True unknown IGKV1 Kappa None None None None None 6lnt H L 0 A | D protein | protein NA | NA envelope protein | pre-membrane protein VIRUS 01/02/20 Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab HOMO SAPIENS; ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013) homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) | zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Tan, T.Y., Fibriansah, G., Kostyuchenko, V.A., Ng, T.S., Lim, X.X., Lim, X.N., Shi, J., Morais, M.C., Corti, D., Lok, S.M. 8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 2qtj D N 5 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7mw6 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with three RBDs up in complex with the Fab fragment of human neutralizing antibody clone 2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.22 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7cn2 H L 0 D protein NA major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 07/29/20 Subparticle refinement of human papillomavirus type 16 pesudovirus in complex with H16.001 Fab HUMAN PAPILLOMAVIRUS TYPE 16; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human papillomavirus type 16 He, M.Z., Li, S.W. 3.43 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 3v4v M N 0 D | C protein | protein NA | NA integrin beta-7 | integrin alpha-4 CELL ADHESION 12/15/11 crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Yu, Y., Zhu, J., Springer, T.A. 3.1 X-RAY DIFFRACTION 0.231 0.197 False True IGHV1 IGKV1 Kappa None None None None None 3inu H L 0 IMMUNE SYSTEM 08/12/09 Crystal structure of an unbound KZ52 neutralizing anti-Ebolavirus antibody. HOMO SAPIENS homo sapiens homo sapiens Lee, J.E., Fusco, M.L., Abelson, D.M., Hessell, A.J., Burton, D.R., Saphire, E.O. 2.5 X-RAY DIFFRACTION 0.252 0.203 False True IGHV3 IGKV4 Kappa None None None None None 7bue H L 0 A protein dengue serotype 2 e protein ectodomain VIRUS 05/13/20 Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 7.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5mzv D NA 0 A protein interleukin-12 subunit beta CYTOKINE 02/01/17 IL-23:IL-23R:Nb22E11 complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Bloch, Y., Savvides, S.N. 2.8 X-RAY DIFFRACTION 0.250 0.212 False True IGHV1 3.6000000000000005e-08 -10.15502031668612 Unknown TBD 6vlr C L 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/24/20 BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 4.42 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 2g2r B A 0 A Hapten TNS 5-[{4-[(E)-2-(4-NITROPHENYL)VINYL]PHENYL}(METHYL)AMINO]PENTANOIC ACID IMMUNE SYSTEM 02/16/06 Green-fluorescent antibody 11G10 in complex with its hapten (nitro-stilbene derivative) MUS MUSCULUS mus musculus mus musculus mus musculus Debler, E.W., Wilson, I.A. 2.75 X-RAY DIFFRACTION 0.250 0.203 False False IGHV1 IGKV1 Kappa 1.3e-08 -10.758506170369841 Unknown TBD 6chb O P 0 H protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 6.801 X-RAY DIFFRACTION 0.417 0.318 False True IGHV1 IGLV2 Lambda None None None None None 7lk4 H G 0 Q protein NA bcl-2 homologous antagonist/killer APOPTOSIS 02/01/21 Crystal structure of BAK L100A in complex with activating antibody fragments HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Robin, Y.A., Colman, P.M. 3.1 X-RAY DIFFRACTION 0.262 0.214 False True IGHV5 IGKV16 Kappa None None None None None 7mnl K M 0 B protein NA e3 sumo-protein ligase ranbp2 TRANSFERASE/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 3.95 X-RAY DIFFRACTION 0.241 0.192 False True IGHV3 IGKV1 Kappa None None None None None 7n9t E NA 0 A protein NA spike glycoprotein ANTIVIRAL PROTEIN/VIRAL PROTEIN 06/18/21 CryoEM structure of SARS-CoV-2 Spike in complex with Nb17 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6pyd A B 0 B Hapten P4S (3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide IMMUNE SYSTEM 07/29/19 Structure of 3E9 antibody Fab bound to marinobufagenin MUS MUSCULUS mus musculus mus musculus mus musculus Franklin, M.C., Macdonald, L.E., McWhirter, J., Murphy, A.J. 2.0 X-RAY DIFFRACTION 0.276 0.229 False True IGHV3 IGKV1 Kappa None None None None None 6ktr F G 0 D protein NA fibroblast growth factor 19 IMMUNE SYSTEM/PROTEIN BINDING 08/28/19 Crystal structure of fibroblast growth factor 19 in complex with Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liu, H., Zheng, S., Hou, X., Liu, X., Lv, X., Li, Y., Li, W., Sui, J. 2.59776 X-RAY DIFFRACTION 0.253 0.202 False True IGHV3 IGLV2 Lambda None None None None None 7jum J j 0 C protein NA gametocyte surface protein p230 CELL INVASION 08/20/20 Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01 PLASMODIUM FALCIPARUM (ISOLATE 3D7); HOMO SAPIENS homo sapiens plasmodium falciparum (isolate 3d7) Tolia, N., Tang, W.K. 1.998 X-RAY DIFFRACTION 0.233 0.191 True True unknown unknown unknown None None None None None 3ux9 D d 0 C protein interferon alpha-1/13 CYTOKINE/IMMUNE SYSTEM 12/04/11 Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus HOMO SAPIENS homo sapiens homo sapiens Ouyang, S., Zhao, L.X., Liang, W., Shaw, N., Liu, Z.-J., Liang, M.-F. 2.8 X-RAY DIFFRACTION 0.243 0.183 True True unknown unknown unknown 7.47e-10 -12.45101842491568 SPR TBD 7kde J I 0 F protein NA envelope glycoprotein gp120 VIRAL PROTEIN/Immune System 10/08/20 BG505 SOSIP.664 in complex with the V3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 6pv7 H I 0 A | B protein | protein NA | NA fusion protein of neuronal acetylcholine receptor subunitalpha-3 and soluble cytochrome b562 | fusion protein of neuronal acetylcholine receptor subunitbeta-4 and soluble cytochrome b562 MEMBRANE PROTEIN 07/19/19 Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine HOMO SAPIENS; ESCHERICHIA COLI O11; MUS MUSCULUS mus musculus mus musculus homo sapiens, escherichia coli o11 | homo sapiens, escherichia coli o11 Gharpure, A., Teng, J., Zhuang, Y., Noviello, C.M., Walsh, R.M., Cabuco, R., Howard, R.J., Zaveri, N.T., Lindahl, E., Hibbs, R.E. 3.34 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 6j11 H L 0 A protein n-terminal domain of spike glycoprotein VIRAL PROTEIN 12/27/18 MERS-CoV spike N-terminal domain and 7D10 scFv complex MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Zhou, H., Zhang, S., Zhang, S., Tang, W., Wang, X. 3.0 X-RAY DIFFRACTION 0.225 0.188 False True IGHV1 IGKV3 Kappa None None None None None 4hxb H L 0 IMMUNE SYSTEM 11/09/12 Crystal structure of 6B9 FAB MUS MUSCULUS mus musculus mus musculus Johal, A.R., Jarrell, H.C., Khieu, N.H., Letts, J.A., Landry, R.C., Jachymek, W., Yang, Q., Jennings, H.J., Brisson, J.R., Evans, S.V. 2.45 X-RAY DIFFRACTION 0.279 0.197 False False IGHV9 IGKV1 Kappa None None None None None 6cue m n 0 c protein unknown VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 6vmk B A 0 C protein NA fab y49r heavy chain HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 5th2 D C 0 IMMUNE SYSTEM 09/28/16 Cetuximab Fab in complex with L5Q meditope variant MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 1.84 X-RAY DIFFRACTION 0.184 0.161 False True IGHV2 IGKV5 Kappa 2.9999999999999997e-05 -6.170310595367968 Unknown TBD 3chn D N 2 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 5boz H NA 0 B protein ricin Hydrolase/Immune system 05/27/15 Ricin A chain bound to camelid nanobody (VHH9)(E1) RICINUS COMMUNIS; LAMA GLAMA lama glama ricinus communis Rudolph, M.J., Mantis, N. 3.1 X-RAY DIFFRACTION 0.277 0.215 False True IGHV1 7e-10 -12.489520888040902 SPR TBD 6n32 K M 0 IMMUNE SYSTEM 11/14/18 Anti-HIV-1 Fab 2G12 re-refinement HOMO SAPIENS homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.227 0.198 False True unknown IGKV1 Kappa None None None None None 6vyh D C 0 A protein NA solute carrier family 40 protein MEMBRANE PROTEIN 02/26/20 Cryo-EM structure of SLC40/ferroportin in complex with Fab CARLITO SYRICHTA; MUS MUSCULUS mus musculus mus musculus carlito syrichta Shen, J., Ren, Z., Pan, Y., Gao, S., Yan, N., Zhou, M. 3 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 7o85 NA E 0 D | F protein | protein NA | NA protective antigen pa-63 | fab TOXIN 04/14/21 Anthrax toxin prepore in complex with the neutralizing Fab cAb29 BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus bacillus anthracis | mus musculus Hoelzgen, F., Zalk, R., Alcalay, R., Cohen-Schwartz, S., Garau, G., Shahar, A., Mazor, O., Frank, G.A. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 3qa3 H F 0 I protein integrin alpha-m IMMUNE SYSTEM/ cell adhesion 01/10/11 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 3.0 X-RAY DIFFRACTION 0.224 0.194 False False IGHV14 IGKV8 Kappa None None None None None 7lr3 A B 0 C protein NA hapless 2 SURFACTANT PROTEIN/IMMUNE SYSTEM 02/15/21 Complex of Fab 2/6.14 with domain 3 of P. berghei HAP2 MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Feng, J., Dong, X.C., Lu, X.F., Springer, T.A. 2.8 X-RAY DIFFRACTION 0.292 0.253 False True IGHV5 IGKV19 Kappa None None None None None 6ssp K NA 0 A | C | B | E | D protein | protein | protein | protein | protein NA | NA | NA | NA | NA cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel | cys-loop ligand-gated ion channel TRANSPORT PROTEIN 09/09/19 Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi | dickeya chrysanthemi | dickeya chrysanthemi | dickeya chrysanthemi | dickeya chrysanthemi Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J. 3.25 X-RAY DIFFRACTION 0.264 0.248 False True IGHV1 NA NA None None None None None 5hj3 I J 0 D | C protein | protein NA | NA envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/12/16 Crystal structure of host-primed Ebola virus GP, GPcl. EBOLA VIRUS SP.; ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens zaire ebolavirus | ebola virus sp. Bornholdt, Z.A., Fusco, M.L., Saphire, E.O. 3.3 X-RAY DIFFRACTION 0.258 0.227 False True IGHV3 IGKV4 Kappa None None None None None 4nyl A B 0 IMMUNE SYSTEM 12/10/13 Crystal structure of adalimumab FAB fragment HOMO SAPIENS homo sapiens homo sapiens Fan, L.J., Lv, L.L., Zhang, Q.J., Chen, C.L. 2.8 X-RAY DIFFRACTION 0.358 0.275 False True IGHV3 IGKV1 Kappa None None None None None 7rq6 D E 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/05/21 Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing NTD-directed CV3-13 Fab isolated from convalescent individual SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, Y., Pozharskiy, E., Tolbert, W.D., Pazgier, M. 4.18 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV1 Kappa None None None None None 5cus H L 0 A protein receptor tyrosine-protein kinase erbb-3 TRANSFERASE 07/25/15 Crystal Structure of sErbB3-Fab3379 Complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, S., Schlessinger, J. 3.2 X-RAY DIFFRACTION 0.278 0.252 False True IGHV3 IGLV1 Lambda None None None None None 6orp H L 0 G protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 5f7e H L 0 IMMUNE SYSTEM 12/08/15 Crystal structure of germ-line precursor of 3BNC60 Fab HOMO SAPIENS homo sapiens homo sapiens Sievers, S.A., Scharf, L., Jiang, S., Bjorkman, P.J. 1.9 X-RAY DIFFRACTION 0.214 0.199 False True IGHV1 IGKV1 Kappa None None None None None 1nlb H L 0 IMMUNE SYSTEM 01/07/03 crystal structure of anti-HCV monoclonal antibody 19D9D6 MUS MUSCULUS mus musculus Menez, R., Bossus, M., Muller, B., Sibai, G., Dalbon, P., Ducancel, F., Jolivet-Reynaud, C., Stura, E. 1.6 X-RAY DIFFRACTION 0.211 0.181 False False IGHV9 IGKV8 Kappa None None None None None 7rga G NA 0 G Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoCLAMP3:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Alexandrov, K. 2.9 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 4ybl H L 0 G protein stabilized inner domain of clade a/e gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/18/15 Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 in complex with the ADCC mediating ANTI-HIV-1 antibody A32 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 3.1 X-RAY DIFFRACTION 0.289 0.232 False True IGHV4 IGLV2 Lambda 1.7000000000000003e-10 -13.328052315201264 SPR TBD 6pe9 C D 0 G protein NA tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM 06/20/19 Crystal Structure of CD40 complexed to FAB516 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Argiriadi, M.A. 3.13 X-RAY DIFFRACTION 0.255 0.216 False True IGHV3 IGKV4 Kappa None None None None None 1aqk H L 0 IMMUNOGLOBULIN 07/30/97 THREE-DIMENSIONAL STRUCTURE OF A HUMAN FAB WITH HIGH AFFINITY FOR TETANUS TOXOID HOMO SAPIENS homo sapiens homo sapiens Faber, C., Fan, Z., Edmundson, A.B. 1.84 X-RAY DIFFRACTION unknown 0.185 False False IGHV3 IGLV1 Lambda None None None None None 6hd9 A NA 0 TRANSPORT PROTEIN 08/17/18 Crystal structure of the potassium channel MtTMEM175 with rubidium LAMA GLAMA; ESCHERICHIA COLI (STRAIN K12); MARIVIRGA TRACTUOSA DSM 4126 lama glama, escherichia coli (strain k12) Brunner, J.D., Jakob, R.P., Schulze, T., Neldner, Y., Moroni, A., Thiel, G., Maier, T., Schenck, S. 3.5 X-RAY DIFFRACTION 0.291 0.289 False True IGHV1 None None None None None 3fmg H L 0 A protein glycoprotein vp7 IMMUNE SYSTEM 12/22/08 Structure of rotavirus outer capsid protein VP7 trimer in complex with a neutralizing Fab SIMIAN ROTAVIRUS; MUS MUSCULUS mus musculus mus musculus simian rotavirus Aoki, S.T., Settembre, E.C., Trask, S.D., Greenberg, H.B., Harrison, S.C., Dormitzer, P.R. 3.4 X-RAY DIFFRACTION 0.238 0.224 False False IGHV1 IGKV12 Kappa None None None None None 3iga A B 0 C protein voltage-gated potassium channel TRANSPORT PROTEIN 07/27/09 Potassium Channel KcsA-Fab complex in Li+ and K+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Thompson, A.N, Ilsoo, K., Panosian, T.D., Iverson, T.M., Allen, T.W., Nimigean, C.M. 2.75 X-RAY DIFFRACTION 0.273 0.242 False False IGHV1 IGKV5 Kappa None None None None None 6b9j A B 0 Y protein imv membrane protein VIRAL PROTEIN/immune system 10/10/17 Structure of vaccinia virus D8 protein bound to human Fab vv138 VACCINIA VIRUS; HOMO SAPIENS homo sapiens homo sapiens vaccinia virus Zajonc, D.M. 2.9 X-RAY DIFFRACTION 0.269 0.241 False False IGHV1 IGKV3 Kappa 3.5e-10 -12.900199280360683 SPR TBD 5lmj A NA 0 IMMUNE SYSTEM 08/01/16 Llama nanobody PorM_19 LAMA GLAMA lama glama Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.210 0.188 False True IGHV1 None None None None None 4nrz A B 0 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66.6 HOMO SAPIENS homo sapiens homo sapiens Ofek, G., Yang, Y., Kwong, P.D. 2.42 X-RAY DIFFRACTION 0.216 0.177 False True IGHV5 IGKV1 Kappa None None None None None 3bdx NA A 0 IMMUNE SYSTEM 11/15/07 Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Fuentes-Silva, D., Del Pozo Yauner, L., Becerril, B., Rodriguez-Romero, A. 2.3 X-RAY DIFFRACTION 0.246 0.205 False True IGLV6 Lambda None None None None None 6ion H L 0 A protein ly6/plaur domain-containing protein 3 IMMUNE SYSTEM 10/30/18 The complex of C4.4A with its antibody 11H10 Fab fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Huang, M.D., Jiang, Y.B., Yuan, C., Lin, L. 2.75 X-RAY DIFFRACTION 0.255 0.197 False False IGHV8 IGKV5 Kappa None None None None None 5uxq A B 0 IMMUNE SYSTEM 02/23/17 Structure of anti-HIV trimer apex antibody PGT143 HOMO SAPIENS homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.415 X-RAY DIFFRACTION 0.267 0.229 False True IGHV1 IGKV2 Kappa None None None None None 6crq I K 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN 03/19/18 Glutaraldehyde-treated BG505 SOSIP.664 Env in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Pallesen, J., Ward, A.B. 4.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6qn9 H L 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV Fab B4 BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 1.89 X-RAY DIFFRACTION 0.254 0.228 False True IGHV1 IGLV1 Lambda None None None None None 6bi0 I M 0 IMMUNE SYSTEM 10/31/17 Trastuzumab Fab N158A, D185A, K190A (Light Chain) Triple Mutant. HOMO SAPIENS homo sapiens homo sapiens DiDonato, M., Spraggon, G. 2.057 X-RAY DIFFRACTION 0.230 0.199 False True IGHV3 IGKV1 Kappa None None None None None 6nb4 H L 0 A protein spike glycoprotein VIRUS 12/06/18 MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2) MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.6 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 6d01 A B 0 I peptide nanp5 IMMUNE SYSTEM 04/09/18 Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Imkeller, K., Wardemann, H., Julien, J.P. 3.2 X-RAY DIFFRACTION 0.227 0.204 False True IGHV3 IGKV1 Kappa 2.86e-07 -8.927113962567878 Unknown TBD 3drq B A 0 C peptide gp41 peptide epitope IMMUNE SYSTEM 07/11/08 Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 FP-MPER Hyb3K construct 514GIGALFLGFLGAAGS528KK-Ahx-655KNEQELLELDKWASLWN671 soaked in PEG/2-propanol solution HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bryson, S., Julien, J.P., Pai, E.F. 2.0 X-RAY DIFFRACTION 0.254 0.227 False True IGHV2 IGKV1 Kappa None None None None None 7m7w A B 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/29/21 Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 2.65 X-RAY DIFFRACTION 0.271 0.221 False True IGHV1 IGLV1 Lambda None None None None None 6d6u J I 0 B protein gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 04/22/18 Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, S., Noviello, C.M., Teng, J., Walsh Jr, R.M., Kim, J.J., Hibbs, R.E. 3.8 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa 6.1e-09 -11.20681521904132 Unknown TBD 7rku G I 0 A | D protein | protein NA | NA spike protein s1 | spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C022 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Jette, C.A., Bjorkman, P.J., Barnes, C.O. 3.2 X-RAY DIFFRACTION 0.231 0.188 False True IGHV4 IGKV1 Kappa None None None None None 6iek E F 0 D protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R12 RIFT VALLEY FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 2.7 X-RAY DIFFRACTION 0.258 0.225 False True IGHV1 IGLV5 Lambda None None None None None 6bzv A B 0 I peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.654 X-RAY DIFFRACTION 0.241 0.199 False True IGHV3 IGKV3 Kappa None None None None None 5acl NA A 0 A Hapten SAS 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID 08/17/15 Mcg immunoglobulin variable domain with methylene blue HOMO SAPIENS homo sapiens homo sapiens Brumshtein, B., Esswein, S.R., Salwinski, L., Phillips, M.L., Ly, A.T., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 1.49 X-RAY DIFFRACTION 0.18742 0.15823 False True IGLV2 Lambda None None None None None 7wly P O 0 B protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 01/14/22 Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down- and 2 up RBDs) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7pi3 I J 0 H protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 7v0v A NA 14 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7eak F L 0 A | C protein | protein NA | NA capsid protein vp1 | capsid protein vp3 VIRUS 03/07/21 Echovirus3 full particle in complex with 5G3 fab ECHOVIRUS E3; MUS MUSCULUS mus musculus mus musculus echovirus e3 | echovirus e3 Feng, R. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 5vjq E F 0 K protein lysozyme HYDROLASE/IMMUNE SYSTEM 04/19/17 Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I) MUS MUSCULUS; ANAS PLATYRHYNCHOS mus musculus mus musculus anas platyrhynchos Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.235 0.193 False True IGHV3 IGKV5 Kappa None None None None None 2yc1 A B 0 C protein beta-mammal toxin cn2 IMMUNE SYSTEM/TOXIN 03/10/11 Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann HOMO SAPIENS; CENTRUROIDES NOXIUS HOFFMANN homo sapiens homo sapiens centruroides noxius hoffmann Canul-Tec, J.C., Riano-Umbarila, L., Rudino-Pinera, E., Becerril, B., Possani, L.D., Torres-Larios, A. 1.9 X-RAY DIFFRACTION 0.21212 0.18613 False True IGHV3 IGKV3 Kappa None None None None None 7ahv A B 0 H protein NA coagulation factor ix BLOOD CLOTTING 09/25/20 Anti-FIXa Fab of mim8 in complex with human FIXa HOMO SAPIENS homo sapiens homo sapiens homo sapiens Johansson, E. 3.11 X-RAY DIFFRACTION 0.284 0.227 False True IGHV3 IGKV1 Kappa None None None None None 4wht M N 0 m peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 4d9l K O 0 IMMUNE SYSTEM 01/11/12 Fab structure of anti-HIV-1 gp120 V2 mAb 697 HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.485 X-RAY DIFFRACTION 0.238 0.176 False True IGHV1 IGLV1 Lambda None None None None None 6s0y A NA 0 C peptide matrix protein 2 ANTIVIRAL PROTEIN 06/18/19 Nanobody targeting influenza A matrix protein 2 ectodomain (M2e) LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama influenza a virus (a/jeju/2279/2007(h1n1)) Van Molle, I., De Vlieger, D., Schepens, B., Remaut, H., Saelens, X. 1.81 X-RAY DIFFRACTION 0.225 0.187 False True IGHV1 None None None None None 4o51 H L 0 M peptide ides hinge peptide IMMUNE SYSTEM 12/19/13 Crystal structure of the QAA variant of anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide ORYCTOLAGUS CUNICULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens homo sapiens Malia, T.J., Luo, J., Teplyakov, A., Gilliland, G.L. 2.204 X-RAY DIFFRACTION 0.213 0.182 False True IGHV1 IGKV1 Kappa None None None None None 7qf1 E D 0 F protein NA spike protein s1 VIRAL PROTEIN 12/03/21 Crystal structure of the SARS-CoV-2 RBD in complex with the human antibody CV2.6264 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fernandez, I., Pederzoli, R., Rey, F.A. 2.8 X-RAY DIFFRACTION 0.254 0.229 False True IGHV1 IGKV1 Kappa None None None None None 3whx A B 0 B Hapten XPG 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid IMMUNE SYSTEM 09/03/13 Crystal structure of anti-prostaglandin E2 Fab fragment PGE1 complex MUS MUSCULUS mus musculus mus musculus mus musculus Sugahara, M., Ago, H., Saino, H., Miyano, M. 1.7 X-RAY DIFFRACTION 0.190 0.168 False False IGHV1 IGKV1 Kappa None None None None None 7oh0 C B 0 A protein NA tetanus toxin TOXIN 05/07/21 Tetanus neurotoxin HC domain in complex with TT104-Fab1 CLOSTRIDIUM TETANI; HOMO SAPIENS homo sapiens homo sapiens clostridium tetani Grinzato, A., Kandiah, E., Zanotti, G. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV3 Kappa None None None None None 5m2m N NA 0 M protein tumor necrosis factor CYTOKINE 10/13/16 Complex between human TNF alpha and Llama VHH3 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.3 X-RAY DIFFRACTION 0.248 0.211 False True IGHV1 1.5000000000000002e-09 -12.037965345328766 SPR TBD 6war N NA 0 M protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 2kh2 B b 50 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6wzj C D 0 F protein NA c-x-c motif chemokine 2 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL2 HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Durbin, J.D., Druzina, Z. 2.37 X-RAY DIFFRACTION 0.242 0.215 False True IGHV1 IGKV3 Kappa None None None None None 1clz H L 0 H carbohydrate FUC polysaccharide IMMUNOGLOBULIN 03/15/95 IGG FAB (IGG3, KAPPA) FRAGMENT (MBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER MUS MUSCULUS mus musculus mus musculus mus musculus Sheriff, S., Bajorath, J. 2.8 X-RAY DIFFRACTION 0.295 0.197 False False IGHV5 IGKV1 Kappa None None None None None 2r2b B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 08/24/07 Crystal structure of S25-2 Fab in complex with Kdo analogues MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 1.6 X-RAY DIFFRACTION 0.253 0.231 False False IGHV7 IGKV8 Kappa 6.3e-05 -5.730724827033278 Unknown TBD 7cws I H 0 O protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike Proteins Trimer in Complex with FC05 and H014 Fabs Cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L., Wang, X. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 1pg7 H L 0 IMMUNE SYSTEM 05/27/03 Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab SYNTHETIC CONSTRUCT; MUS MUSCULUS synthetic construct synthetic construct Eigenbrot, C., Meng, Y.G., Krishnamurthy, R., Lipari, M.T., Presta, L., Devaux, B., Wong, T., Moran, P., Bullens, S., Kirchhofer, D. 2.5 X-RAY DIFFRACTION 0.265 0.217 False True IGHV3 IGKV1 Kappa None None None None None 5h37 I M 0 C protein structural protein e VIRUS/IMMUNE SYSTEM 10/20/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lim, X.-N., Ooi, J.S.G., Lambert, S., Tan, T.Y., Widman, D., Shi, J., Baric, R.S., Lok, S.-M. 4 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7a65 C B 0 A protein NA multidrug resistance protein 1 TRANSPORT PROTEIN 08/25/20 Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nosol, K., Locher, K.P. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7ey0 H L 0 R protein NA spike glycoprotein VIRAL PROTEIN 05/29/21 Local CryoEM structure of the SARS-CoV-2 S6PV2 in complex with BD-813 Fab and BD-744 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3ijs B A 0 A carbohydrate GP4 polysaccharide IMMUNE SYSTEM 08/04/09 Structure of S67-27 in Complex with TSBP MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.55 X-RAY DIFFRACTION 0.261 0.217 False False IGHV7 IGKV8 Kappa None None None None None 1uyw M N 0 IMMUNE SYSTEM 03/03/04 Crystal Structure of the antiflavivirus Fab4g2 MUS MUSCULUS mus musculus mus musculus Martinez-Fleites, C., Ortiz-Lombardia, M., Taylor, E.J., Gil-Valdes, J., Chinea, G., Davies, G. 2.0 X-RAY DIFFRACTION 0.21953 0.19943 False False IGHV1 IGKV6 Kappa None None None None None 7t4r J I 0 B protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11 HOMO SAPIENS; HUMAN BETAHERPESVIRUS 5 homo sapiens homo sapiens human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7nfd F E 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 02/06/21 Structure of mitoxantrone-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kowal, J., Locher, K., Ni, D., Stahlberg, H. 3.51 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 7kc1 E F 0 D | C protein | protein NA | NA fusion protein of hemagglutinin and envelope glycoprotein | hemagglutinin IMMUNE SYSTEM 10/04/20 Cryo-EM structure of SRR2899884.46167H+MEDI8852L fab in complex with Victoria HA INFLUENZA A VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens influenza a virus, human immunodeficiency virus1 | influenza a virus Gorman, J., Kwong, P.D. 3.41 ELECTRON MICROSCOPY NA NA False True IGHV6 IGKV1 Kappa None None None None None 3cfi F NA 0 E protein type ii secretory pathway, pseudopilin epsj PROTEIN TRANSPORT/Immune system 03/03/08 Nanobody-aided structure determination of the EPSI:EPSJ pseudopilin heterdimer from Vibrio Vulnificus VIBRIO VULNIFICUS; LAMA GLAMA lama glama vibrio vulnificus Lam, A.Y., Pardon, E., Korotkov, K.V., Steyaert, J., Hol, W.G.J. 2.58 X-RAY DIFFRACTION 0.279 0.229 False True IGHV3 None None None None None 4y5v G H 0 I protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 2.604 X-RAY DIFFRACTION 0.229 0.187 False True IGHV3 IGLV2 Lambda None None None None None 1ap2 B A 0 IMMUNOGLOBULIN 07/23/97 SINGLE CHAIN FV OF C219 MUS MUSCULUS mus musculus mus musculus Hoedemaeker, P.J., Rose, D.R. 2.36 X-RAY DIFFRACTION 0.284 0.204 True True IGHV14 IGKV8 Kappa None None None None None 5kzc E G 0 F protein engineered outer domain of gp120 IMMUNE SYSTEM 07/24/16 Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Julien, J.-P., Jardine, J.G., Diwanji, D., Schief, W.R., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.274 0.223 False True unknown IGKV3 Kappa None None None None None 7q9k D E 0 B protein NA spike glycoprotein VIRAL PROTEIN 11/12/21 Beta-32 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3l95 B A 0 X protein neurogenic locus notch homolog protein 1 IMMUNE SYSTEM 01/04/10 Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Hymowitz, S.G., de Leon, G.P. 2.19 X-RAY DIFFRACTION 0.271 0.222 False True IGHV3 IGKV1 Kappa 2.50e-09 -11.73 SPR 25 20393564 3tt1 I M 0 A protein leucine transporter leut TRANSPORT PROTEIN 09/13/11 Crystal Structure of LeuT in the outward-open conformation in complex with Fab AQUIFEX AEOLICUS; MUS MUSCULUS mus musculus mus musculus aquifex aeolicus Krishnamurthy, H., Gouaux, E. 3.099 X-RAY DIFFRACTION 0.240 0.219 False True IGHV1 IGKV3 Kappa None None None None None 7a3n H L 0 A protein NA core protein VIRAL PROTEIN 08/18/20 Crystal structure of Zika virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C10 ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Sharma, A., Vaney, M.C., Guardado-Calvo, P., Duquerroy, S., Rouvinski, A., Rey, F.A. 2.1 X-RAY DIFFRACTION 0.240 0.203 False True IGHV1 IGLV2 Lambda None None None None None 7dk7 c d 0 B protein NA the light chain fragment of 2h2 fab VIRAL PROTEIN 11/23/20 S-2H2-F3b structure, three RBDs are up and each RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 9.7 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 7l1v S NA 0 R protein NA hypocretin receptor type 2 MEMBRANE PROTEIN 12/15/20 Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1 HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA lama glama homo sapiens Hong, C., Byrne, N.J., Zamlynny, B., Tummala, S., Xiao, L., Shipman, J.M., Partridge, A.T., Minnick, C., Breslin, M.J., Rudd, M.T., Stachel, S.J., Rada, V.L., Kern, J.C., Armacost, K.A., Hollingsworth, S.A., O'Brien, J.A., Hall, D.L., McDonald, T.P., Strickland, C., Brooun, A., Soisson, S.M., Hollenstein, K. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7rth k NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 4ut9 I M 0 B protein envelope glycoprotein e VIRAL PROTEIN 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein dimer in complex with the ScFv fragment of the broadly neutralizing human antibody EDE1 C10 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 ROUVINSKI, A., GUARDADO-CALVO, P., BARBA-SPAETH, G., DUQUERROY, S., VANEY, M.C., REY, F.A. 3.2 X-RAY DIFFRACTION 0.2487 0.1975 False True IGHV1 IGLV2 Lambda None None None None None 3lh2 J N 0 U protein 4e10_1vi7a_s0_002_n (t88) IMMUNE SYSTEM 01/21/10 Crystal structure of HIV epitope-scaffold 4E10_1VI7A_S0_002_N 4E10 Fv complex ARTIFICIAL GENE; HOMO SAPIENS homo sapiens homo sapiens artificial gene Holmes, M.A. 2.65 X-RAY DIFFRACTION 0.270 0.222 False True IGHV1 IGKV3 Kappa 5.60e-09 -11.25 SPR 20826338 6mwc K L 0 J protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.5 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 7e7e C D 0 B protein NA processed angiotensin-converting enzyme 2 ANTIVIRAL PROTEIN 02/26/21 The co-crystal structure of ACE2 with Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xiao, J.Y., Zhang, Y. 3.8 X-RAY DIFFRACTION 0.327 0.276 False True IGHV3 IGKV1 Kappa None None None None None 7eng H L 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/16/21 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with Fab30 (local refinement of the RBD and Fab30) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 6fn1 C B 0 A protein human-mouse chimeric abcb1 (abcbhm) MEMBRANE PROTEIN 02/02/18 Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Alam, A., Locher, K.P. 3.58 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 3cm9 D O 0 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7nez D C 0 B protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 02/05/21 Structure of topotecan-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kowal, J., Locher, K., Ni, D., Stahlberg, H. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 4tsc H L 0 A protein lysozyme c Immune system/Hydrolase 06/18/14 Structure of a lysozyme antibody complex HOMO SAPIENS; GALLUS GALLUS homo sapiens homo sapiens gallus gallus Wensley, B. 1.92 X-RAY DIFFRACTION 0.232 0.209 False True IGHV3 IGLV1 Lambda None None None None None 6pcu F E 0 D protein outer capsid protein vp4 viral protein/immune system 06/18/19 VP8* of a G2P[4] human rotavirus in complex with scFv antibody 9 ROTAVIRUS A; HOMO SAPIENS homo sapiens homo sapiens rotavirus a Hu, L., Venkataram Prasad, B.V. 2.4 X-RAY DIFFRACTION 0.237 0.186 False True IGHV4 IGLV9 Lambda None None None None None 4kaq H L 0 IMMUNE SYSTEM 04/22/13 Structure of rituximab Fab HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.230 0.180 False True IGHV1 IGKV4 Kappa None None None None None 6qd7 H L 0 D | C protein | protein NA | NA envelope glycoprotein | envelope glycoprotein,virion spike glycoprotein,ebov-gp1 VIRAL PROTEIN 01/01/19 EM structure of a EBOV-GP bound to 3T0331 neutralizing antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus | ebola virus Diskin, R., Cohen-Dvashi, H. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4hgw B A 0 B carbohydrate KTU polysaccharide IMMUNE SYSTEM 10/08/12 Crystal structure of S25-2 in complex with a 5,6-dehydro-Kdo disaccharide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 1.65 X-RAY DIFFRACTION 0.198 0.176 False True IGHV7 IGKV8 Kappa None None None None None 6v8z D E 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 2.9 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 7sn1 H L 0 NA NA NA NA IMMUNE SYSTEM 10/27/21 Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab HOMO SAPIENS homo sapiens homo sapiens Pan, J., Abraham, J., Clark, S. 1.467 X-RAY DIFFRACTION 0.206 0.178 False True IGHV3 IGKV3 Kappa None None None None None 1ejo H L 0 P peptide fmdv peptide IMMUNE SYSTEM 03/03/00 FAB FRAGMENT OF NEUTRALISING MONOCLONAL ANTIBODY 4C4 COMPLEXED WITH G-H LOOP FROM FMDV. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Ochoa, W.F., Kalko, S.G., Gomes, P., Fita, I., Verdaguer, N. 2.3 X-RAY DIFFRACTION 0.262 0.248 False False IGHV5 IGKV3 Kappa None None None None None 3eob B A 0 J protein integrin alpha-l IMMUNE SYSTEM/CELL ADHESION 09/26/08 Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, S., Ding, J. 3.6 X-RAY DIFFRACTION 0.333 0.267 False True IGHV3 IGKV1 Kappa 2.20e-09 -11.8 SPR 25 19258452 2kh2 B b 37 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5gs1 K k 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 4x4x C D 0 IMMUNE SYSTEM 12/04/14 Retrofitting antibodies with stabilizing mutations. Herceptin scFv mutant. HOMO SAPIENS homo sapiens homo sapiens Langley, D.B., Roome, B., Christ, D. 2.25 X-RAY DIFFRACTION 0.269 0.226 False True IGHV3 IGKV1 Kappa None None None None None 7e53 B NA 0 A protein NA green fluorescent protein FLUORESCENT PROTEIN 02/16/21 Crystal structure of sfGFP complexed with the nanobody nb2 at 2.2 Angstron resolution AEQUOREA VICTORIA; CAMELUS BACTRIANUS camelus bactrianus aequorea victoria Ding, Y., Zhong, P.Y. 2.21 X-RAY DIFFRACTION 0.258 0.204 False True IGHV1 NA NA None None None None None 6ohg C B 0 A protein gametocyte surface protein p230 IMMUNE SYSTEM 06/17/20 Structure of Plasmodium falciparum vaccine candidate Pfs230D1M in complex with the Fab of a transmission blocking antibody PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Garboczi, D.N., Singh, K., Gittis, A.G. 2.385 X-RAY DIFFRACTION 0.277 0.229 False True IGHV1 IGKV5 Kappa None None None None None 6mb3 A K 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6mug D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/23/18 Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-386150 in Complex with Human Antibodies 3H109L and 35O22 at 3.8 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.954 X-RAY DIFFRACTION 0.290 0.230 False True unknown unknown unknown None None None None None 7qn6 L NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1za6 D C 0 IMMUNE SYSTEM 04/05/05 The structure of an antitumor CH2-domain-deleted humanized antibody HOMO SAPIENS homo sapiens homo sapiens Larson, S.B., Day, J.S., Glaser, S., Braslawsky, G., McPherson, A. 2.8 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV4 Kappa None None None None None 5y9f T S 0 E protein NA major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 1rzi N M 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 5dyo A B 0 H Hapten FDS FLUORESCIN IMMUNE SYSTEM 09/25/15 Fab43.1 complex with flourescein MUS MUSCULUS mus musculus mus musculus mus musculus Longenecker, K.L., Judge, R.A. 2.36 X-RAY DIFFRACTION 0.239 0.193 False True IGHV1 IGKV1 Kappa 6.1e-11 -13.935303397861828 Unknown TBD 7nfa C A 0 NA NA NA NA IMMUNE SYSTEM 02/05/21 The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer HOMO SAPIENS homo sapiens homo sapiens Tang, J., Zhang, C., Dalby, P., Kozielski, F. 2.3 X-RAY DIFFRACTION 0.260 0.193 False True IGHV3 IGKV1 Kappa None None None None None 4bfb D NA 0 A protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 03/18/13 BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 2.21 X-RAY DIFFRACTION 0.27320 0.20370 False True IGHV3 None None None None None 6wgk E F 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.62 X-RAY DIFFRACTION 0.236 0.210 False True IGHV3 IGKV2 Kappa None None None None None 1nd0 D C 0 C Hapten DP4 (1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE 1-OXIDE IMMUNE SYSTEM 12/05/02 CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.286 0.242 False False IGHV3 IGKV1 Kappa None None None None None 7dr4 H L 0 K protein NA interleukin-2 IMMUNE SYSTEM 12/25/20 Complex of anti-human IL-2 antibody and human IL-2 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Kim, M.S., Kim, J.E. 2.49 X-RAY DIFFRACTION 0.258 0.195 False True IGHV1 IGKV17 Kappa None None None None None 7piu N NA 0 A | B protein | protein NA | NA isoform gnas-2 of guanine nucleotide-binding protein g(s)subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 08/23/21 Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution. HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | rattus norvegicus Heyder, N.A., Schmidt, A., Kleinau, G., Hilal, T., Scheerer, P. 2.58 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3uze A a 0 C protein envelope protein IMMUNE SYSTEM 12/07/11 Crystal structure of the dengue virus serotype 3 envelope protein domain III in complex with the variable domains of Mab 4E11 MUS MUSCULUS; DENGUE VIRUS 3 mus musculus dengue virus 3 Cockburn, J.J.B., Navarro Sanchez, M.E., Fretes, N., Urvoas, A., Staropoli, I., Kikuti, C.M., Coffey, L.L., Arenzana Seisdedos, F., Bedouelle, H., Rey, F.A. 2.04 X-RAY DIFFRACTION 0.234 0.218 True True unknown unknown unknown 8e-09 -11.046161627732946 ELISA TBD 4r7d G H 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 6wzj A B 0 E protein NA c-x-c motif chemokine 2 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL2 HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Durbin, J.D., Druzina, Z. 2.37 X-RAY DIFFRACTION 0.242 0.215 False True IGHV1 IGKV3 Kappa None None None None None 5ud9 H L 0 IMMUNE SYSTEM 12/23/16 Crystal structure of 354BG18 Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 1.3 X-RAY DIFFRACTION 0.188 0.180 False True unknown IGLV3 Lambda None None None None None 1yyl H L 0 G protein exterior membrane glycoprotein(gp120) Viral protein/Immune system 02/25/05 crystal structure of CD4M33, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.C., Stricher, F., Martin, L., Decker, J.M., Majeed, S., Barthe, P., Hendrickson, W.A., Robinson, J., Roumestand, C., Sodroski, J., Wyatt, R., Shaw, G.M., Vita, C., Kwong, P.D. 2.75 X-RAY DIFFRACTION 0.275 0.202 False True IGHV1 IGKV3 Kappa 4.00e-09 -11.9 ITC 37 15893666 3wif A B 0 A Hapten ON5 (Z)-7-[(1R,2R,3R,5R)-5-chloranyl-3-oxidanyl-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid IMMUNE SYSTEM 09/12/13 Crystal structure of anti-prostaglandin E2 Fab fragment 9Cl-PGF2beta complex MUS MUSCULUS mus musculus mus musculus mus musculus Sugahara, M., Ago, H., Saino, H., Miyano, M. 1.7 X-RAY DIFFRACTION 0.190 0.172 False False IGHV1 IGKV1 Kappa None None None None None 6hjx J NA 0 E protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.5 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 None None None None None 6wtv B C 0 A protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 258259 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.05 X-RAY DIFFRACTION 0.277 0.235 False True IGHV3 IGLV3 Lambda None None None None None 7tm0 J K 0 B protein NA spike glycoprotein VIRUS 01/19/22 SARS-CoV-2 S B.1.1.529 Omicron variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7lo8 H L 0 Z protein NA quinolone resistance protein nora TRANSPORT PROTEIN 02/09/21 NorA in complex with Fab36 STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus Brawley, D.N., Sauer, D.B., Song, J.M., Koide, A., Koide, S., Traaseth, N.J., Wang, D.N. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4i18 A B 0 R protein prolactin receptor CYTOKINE, SIGNALING PROTEIN 11/20/12 Crystal structure of human prolactin receptor complexed with Fab fragment MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Duguid, E.M., Mukherjee, S., Kouadio, J.L. 3.238 X-RAY DIFFRACTION 0.246 0.191 False True IGHV3 IGKV1 Kappa 5.6e-09 -11.25748571108156 SPR TBD 6uga B A 0 IMMUNE SYSTEM 09/26/19 ch28/11 Fab (monoclinic form) MUS MUSCULUS mus musculus mus musculus Soliman, C., Ramsland, P.A. 2.5 X-RAY DIFFRACTION 0.239 0.164 False True IGHV2 IGKV4 Kappa None None None None None 7zf4 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-9 Fab and nanobody F2 LAMA GLAMA; HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.18 X-RAY DIFFRACTION 0.385 0.370 False True IGHV3 IGLV3 Lambda None None None None None 4xmk I M 0 Q peptide hiv-1 jr-fl gp120 v3 peptide immune system/viral protein 01/14/15 Crystal structure of Fab of HIV-1 gp120 V3-specific human monoclonal antibody 2424 in complex with JR-FL V3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P., Pan, R. 3.179 X-RAY DIFFRACTION 0.283 0.225 False True IGHV3 IGKV2 Kappa None None None None None 4ocr H L 0 IMMUNE SYSTEM 01/09/14 Crystal structure of human Fab CAP256-VRC26.01, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 1.895 X-RAY DIFFRACTION 0.200 0.180 False True IGHV3 IGLV1 Lambda None None None None None 3uls H L 0 IMMUNE SYSTEM 11/11/11 Crystal structure of Fab12 HOMO SAPIENS homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 2.495 X-RAY DIFFRACTION 0.267 0.212 False True IGHV6 IGLV3 Lambda None None None None None 7nx0 E NA 0 B protein NA leukocyte tyrosine kinase receptor PROTEIN BINDING 03/17/21 Extracellular TG and EGF-like domains of ALK HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens De Munck, S., Savvides, S.N. 1.95 X-RAY DIFFRACTION 0.196 0.169 False True IGHV1 NA NA None None None None None 7nd7 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6qb9 X x 0 APOPTOSIS 12/20/18 Structure of an anti-Mcl1 scFv HOMO SAPIENS homo sapiens Hargreaves, D. 1.85 X-RAY DIFFRACTION 0.239 0.200 True True unknown unknown unknown None None None None None 6hco F E 0 A protein atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 08/15/18 Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Kowal, J., Stahlberg, H., Locher, K.P. 3.58 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 3skj H L 0 E protein ephrin type-a receptor 2 IMMUNE SYSTEM 06/22/11 Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., Wu, H., Dall'Acqua, W.F. 2.5 X-RAY DIFFRACTION 0.271 0.216 False True IGHV3 IGKV1 Kappa 8.10e-10 -12.4 SPR 21867711 6lyn H L 0 D protein NA cell surface glycoprotein muc18 CELL ADHESION 02/14/20 CD146 D4-D5/AA98 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Chen, X., Yan, X. 2.776 X-RAY DIFFRACTION 0.262 0.217 False True IGHV1 IGKV3 Kappa None None None None None 6pzy G J 0 B protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-73 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.17 ELECTRON MICROSCOPY False True IGHV4 IGLV1 Lambda None None None None None 6m1h C NA 0 F | E protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 PROTEIN BINDING 02/26/20 CryoEM structure of human PAC1 receptor in complex with maxadilan HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Song, X., Wang, J., Zhang, D., Wang, H.W., Ma, Y. 3.6 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6dg2 C D 0 IMMUNE SYSTEM 05/16/18 Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6 MUS MUSCULUS mus musculus mus musculus Milligan, J.C., Saphire, E.O. 1.96 X-RAY DIFFRACTION 0.235 0.191 False True IGHV1 IGKV6 Kappa None None None None None 4kjw E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN, membrane protein 05/03/13 Structure of the CLC-ec1 deltaNC construct in 100mM fluoride and 20mM bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.03 X-RAY DIFFRACTION 0.269 0.230 False True IGHV4 IGKV4 Kappa None None None None None 5w1m B A 0 R protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 MACV GP1 CR1-07 Fab complex HOMO SAPIENS; MACHUPO VIRUS homo sapiens homo sapiens machupo virus Raymond, D.D., Clark, L.E., Abraham, J. 3.91 X-RAY DIFFRACTION 0.264 0.248 False True IGHV3 IGKV4 Kappa 1.63e-08 -10.624477030127814 SPR TBD 7seg A B 0 D protein NA low affinity immunoglobulin gamma fc region receptor iii-a ANTITUMOR PROTEIN 09/30/21 Crystal structure of the complex of CD16A bound by an anti-CD16A Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kiefer, J.R., Wallweber, H.A., Polson, A.G. 2.156 X-RAY DIFFRACTION 0.234 0.189 False True IGHV1 IGLV3 Lambda None None None None None 7lq7 P Q 0 A protein NA spike protein s1 IMMUNE SYSTEM 02/13/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 IGKV1 Kappa None None None None None 6nbf N NA 0 A | B protein | protein NA | NA gs protein alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/07/18 Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y. 3.0 ELECTRON MICROSCOPY False True IGHV3 None None None None None 5mv4 U V 0 W peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 3b2u C D 0 B protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 7n0i J NA 0 C | D protein | protein NA | NA nucleoprotein | nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/25/21 Structure of the SARS-CoV-2 N protein C-terminal domain bound to single-domain antibody E2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Ye, Q., Corbett, K.D. 2.2 X-RAY DIFFRACTION 0.271 0.239 False True IGHV1 NA NA None None None None None 1wcb H L 0 IMMUNE SYSTEM 11/12/04 PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH ITS HAPTEN MUS MUSCULUS mus musculus mus musculus Pimpaneau, Beatrice Golinelli-, Christen, P. 2.5 X-RAY DIFFRACTION 0.2899 0.2230 False True IGHV7 IGKV4 Kappa None None None None None 4d9r E D 0 B protein complement factor d HYDROLASE/IMMUNE SYSTEM 01/11/12 Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D HOMO SAPIENS homo sapiens homo sapiens homo sapiens Murray, J.M., Wiesmann, C. 2.42 X-RAY DIFFRACTION 0.251 0.213 False True IGHV7 IGKV1 Kappa 4e-12 -15.549572288283489 SPR TBD 4m7z B C 0 IMMUNE SYSTEM 08/12/13 Unliganded 1 crystal structure of S25-26 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V., Muller-Loennies, S., Saldova, R., Muniyappa, M., Brade, L., Rudd, P.M., Harvey, D.J., Kosma, P., Brade, H. 2.75 X-RAY DIFFRACTION 0.238 0.216 False False IGHV2 IGKV1 Kappa None None None None None 7ws3 G F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ws6 I H 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5mx3 H L 0 IMMUNE SYSTEM 01/20/17 Structure of DC8E8 Fab crystallized at pH 8.5 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.98 X-RAY DIFFRACTION 0.256 0.219 False False IGHV1 IGKV8 Kappa None None None None None 6vgr C D 0 A protein dipeptidase 3 HYDROLASE 05/13/20 Crystal Structure of Human Dipeptidase 3 in Complex with Fab of SC-003 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hayashi, K., Longenecker, K.L., Vivona, S. 2.84 X-RAY DIFFRACTION 0.248 0.190 False True IGHV1 IGKV3 Kappa None None None None None 4hg4 T U 0 F | c protein | protein NA | NA hemagglutinin ha2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 2kqm NA B 19 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 2ht2 E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/25/06 Structure of the Escherichia coli ClC chloride channel Y445H mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.32 X-RAY DIFFRACTION 0.305 0.270 False False IGHV4 IGKV4 Kappa None None None None None 7phg H L 0 A protein NA surface glycoprotein VIRAL PROTEIN 08/17/21 MaP OF P5C3RBD Interface SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Perez, L. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7s0b A B 0 F protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 RBD in complex with neutralizing antibody N-612-056 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tanaka, S., Barnes, C.O., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.260 0.215 False True IGHV3 IGKV1 Kappa None None None None None 1q9w B A 0 B carbohydrate KDO polysaccharide IMMUNE SYSTEM 08/26/03 S45-18 Fab pentasaccharide bisphosphate complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Nguyen, H.P., Seto, N.O., MacKenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.75 X-RAY DIFFRACTION 0.247 0.212 False False IGHV7 IGKV8 Kappa None None None None None 7dw9 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/15/21 Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Zhou, F., Jiang, Y. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7u8m N O 0 C protein NA hemagglutinin ha1 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 5.39 X-RAY DIFFRACTION 0.342 0.304 False True IGHV4 IGKV1 Kappa None None None None None 6x06 K NA 0 A protein NA nucleoporin nup120 STRUCTURAL PROTEIN 05/15/20 Nup120 (aa1-757) from S. cerevisiae bound by VHH-SAN11 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Knockenhauer, K.E., Nordeen, S.A., Schwartz, T.U. 4.27 X-RAY DIFFRACTION 0.359 0.334 False True IGHV1 NA NA None None None None None 6e8v O P 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False True IGHV1 IGLV1 Lambda None None None None None 3c6s B A 0 B carbohydrate RAM polysaccharide IMMUNE SYSTEM 02/05/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag pentadecasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.251 0.191 False False IGHV6 IGKV2 Kappa None None None None None 4qxu H L 0 K peptide matrix metalloproteinase-14 IMMUNE SYSTEM 07/22/14 Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Udi, Y., Grossman, M., Solomonov, I., Dym, O., Rozenberg, H., Moreno, v., Cuiniasse, P., Dive, V., Arroyo, A.G., Sagi, I., Israel Structural Proteomics Center (ISPC) 2.3 X-RAY DIFFRACTION 0.293 0.243 False True IGHV5 IGKV1 Kappa None None None None None 2kqn NA A 8 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7lmn NA B 0 A Hapten NY3 2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl ~{N}-[[3-(1~{H}-imidazol-5-yl)phenyl]methyl]carbamate IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 26 [2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl (3-(1H-imidazol-4-yl)benzyl)carbamate] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.01 X-RAY DIFFRACTION 0.239 0.187 False True NA IGLV6 Lambda None None None None None 3mlt E D 0 IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens Kong, X.-P. 2.49 X-RAY DIFFRACTION 0.280 0.202 False False IGHV5 IGLV3 Lambda None None None None None 1shm A NA 0 IMMUNE SYSTEM 02/26/04 Convergent solutions to VHH domain stabilization from natural and in vitro evolution LAMA GLAMA lama glama Bond, C.J., Wiesmann, C., Marsters, J.C., Sidhu, S.S. 1.9 X-RAY DIFFRACTION 0.236 0.185 False True IGHV1 None None None None None 5wob W X 0 H protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 4rgn H L 0 S protein enterotoxin type b TOXIN/IMMUNE SYSTEM 09/30/14 Structure of Staphylococcal Enterotoxin B bound to two neutralizing antibodies, 14G8 and 6D3 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Franklin, M.C., Dutta, K., Varshney, A.K., Goger, M.J., Fries, B.C. 2.698 X-RAY DIFFRACTION 0.278 0.240 False False IGHV5 IGKV5 Kappa None None None None None 3fb7 A B 0 C protein voltage-gated potassium channel membrane protein/metal transport 11/18/08 Open KcsA potassium channel in the presence of Rb+ ion STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M, Pan, A.C., Gagnon, D.H., Cordero-Morales, J.F., Chakrapani, S., Roux, B., Perozo, E. 3.3 X-RAY DIFFRACTION 0.255 0.241 False False IGHV1 IGKV5 Kappa None None None None None 7kzc C D 0 NA NA NA NA IMMUNE SYSTEM 12/10/20 Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies HOMO SAPIENS homo sapiens homo sapiens Langley, D.B., Christ, D. 2.3 X-RAY DIFFRACTION 0.257 0.212 False True IGHV1 IGLV3 Lambda None None None None None 5fhx H NA 0 A protein interleukin-4 IMMUNE SYSTEM 12/22/15 CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION. HOMO SAPIENS homo sapiens homo sapiens Vallee, F., Dupuy, A., Rak, A. 2.55 X-RAY DIFFRACTION 0.249 0.184 False True IGHV2 1.2e-11 -14.898662436600187 SPR TBD 4qhl C D 0 IMMUNE SYSTEM 05/28/14 I3.2 (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.153 X-RAY DIFFRACTION 0.281 0.237 False True IGHV4 IGLV3 Lambda None None None None None 5hpm B A 0 IMMUNE SYSTEM 01/20/16 Cetuximab Fab in complex with cyclic linked meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.67 X-RAY DIFFRACTION 0.232 0.187 False True IGHV2 IGKV5 Kappa 7.4e-08 -9.728108479311139 Unknown TBD 2kqn NA B 17 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1seq H L 0 IMMUNE SYSTEM 02/18/04 Fab MNAC13 MUS MUSCULUS mus musculus mus musculus Covaceuszach, S., Cattaneo, A., Lamba, D. 1.78 X-RAY DIFFRACTION 0.232 0.194 False False IGHV5 IGKV4 Kappa None None None None None 3u4e H L 0 G protein v1v2 region of hiv-1 on 1fd6 scaffold IMMUNE SYSTEM 10/07/11 Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain CAP45 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., McLellan, J., Pancera, M., Kwong, P.D. 2.185 X-RAY DIFFRACTION 0.234 0.182 False True IGHV3 IGLV2 Lambda None None None None None 4x7t A B 0 IMMUNE SYSTEM 12/09/14 Structure of Omalizumab Fab fragment, crystal form 2 HOMO SAPIENS homo sapiens homo sapiens Jensen, R.K., Andersen, G.R. 3.0 X-RAY DIFFRACTION 0.237 0.193 False True IGHV3 IGKV1 Kappa None None None None None 6p67 H L 0 NA NA NA NA IMMUNE SYSTEM 06/03/19 Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Walsh, S.T.R., Kashi, L., Kohnhorst, C.L. 2.9 X-RAY DIFFRACTION 0.266 0.249 False True IGHV1 IGKV6 Kappa None None None None None 1wej H L 0 F protein cytochrome c COMPLEX (ANTIBODY/ELECTRON TRANSPORT) 03/26/98 IGG1 FAB FRAGMENT (OF E8 ANTIBODY) COMPLEXED WITH HORSE CYTOCHROME C AT 1.8 A RESOLUTION MUS MUSCULUS; EQUUS CABALLUS mus musculus mus musculus equus caballus Mylvaganam, S.E., Paterson, Y., Getzoff, E.D. 1.8 X-RAY DIFFRACTION 0.256 0.200 False False IGHV14 IGKV12 Kappa 1.58e-08 -10.63 ITC 25 7539913 6wx1 H L 0 NA NA NA NA IMMUNE SYSTEM 05/09/20 Antigen Binding Fragment of OKT9 MUS MUSCULUS mus musculus mus musculus Rodriguez, J.A., Helguera, G., Sawaya, M., Cascio, D., Collazo, M., Flores, M., Zink, S., Ferrero, S., Payes, C., Fuentes, D., Short, C. 2.0 X-RAY DIFFRACTION 0.254 0.216 False False IGHV1 IGKV8 Kappa None None None None None 6kpg S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/15/19 Cryo-EM structure of CB1-G protein complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Hua, T., Li, X.T., Wu, L.J., Makriyannis, A., Wang, Y.X., Shen, L., Liu, Z.J. 3 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 5y11 A B 0 C protein membrane glycoprotein polyprotein IMMUNE SYSTEM/VIRAL SYSTEM 07/19/17 SFTSV GN with neutralizing antibody MAb4-5 HOMO SAPIENS; SEVERE FEVER WITH THROMBOCYTOPENIA VIRUS homo sapiens homo sapiens severe fever with thrombocytopenia virus Wu, Y., Gao, F., Qi, J.X., Chai, Y., Gao, G.F. 2.1 X-RAY DIFFRACTION 0.210 0.169 False True IGHV5 IGKV3 Kappa 2.59e-08 -10.350110954979534 SPR TBD 7vdh S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/07/21 Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yu, L., Fang, Y. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7a50 C NA 0 D peptide NA coiled-coil aph DE NOVO PROTEIN 08/20/20 Crystal structure of the APH coiled-coil in complex with nanobody Nb26 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 1.999 X-RAY DIFFRACTION 0.226 0.182 False True IGHV1 NA NA None None None None None 7lmq NA B 0 A Hapten 9ZW 4-methyl-3-(morpholin-4-ylmethyl)-7-[(1~{R})-1-phenylethoxy]chromen-2-one IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 62 [4-methyl-3-(morpholinomethyl)-7-(1-phenylethoxy)-2H-chromen-2-one] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 1.91 X-RAY DIFFRACTION 0.203 0.161 False True NA IGLV6 Lambda None None None None None 1mcd NA A 0 P peptide peptide n-acetyl-d-phe-b-ala-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 3ikc D C 0 C carbohydrate KDO 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID IMMUNE SYSTEM 08/05/09 Structure of S67-27 in Complex with Kdo(2.8)-7-O-methyl-Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.6 X-RAY DIFFRACTION 0.291 0.235 False False IGHV7 IGKV8 Kappa 3.5e-08 -10.171711101540176 Unknown TBD 1cfn B A 0 C peptide protein (bound peptide) POLYSPECIFICITY 03/19/99 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-RELATED PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J., Hoehne, W. 2.65 X-RAY DIFFRACTION 0.325 0.277 False False IGHV1 IGKV14 Kappa None None None None None 7n0r C NA 0 A protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/25/21 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody C2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Ye, Q., Corbett, K.D. 1.42 X-RAY DIFFRACTION 0.166 0.141 False True IGHV3 NA NA None None None None None 5ovw L NA 0 F protein vitamin b12-binding protein TRANSPORT PROTEIN 08/30/17 Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Mireku, S.A., Sauer, M.M., Glockshuber, R., Locher, K.P. 2.653 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 None None None None None 4n90 D E 0 R | A protein | protein NA | NA tumor necrosis factor receptor superfamily member 10b | tumor necrosis factor ligand superfamily member 10 Apoptosis/Immune System 10/18/13 Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Huang, X. 3.3 X-RAY DIFFRACTION 0.286 0.229 False True IGHV4 IGKV3 Kappa None None None None None 6j6y E F 0 D protein fibroblast growth factor receptor 4 TRANSFERASE/IMMUNE SYSTEM 01/16/19 FGFR4 D2 - Fab complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Takahashi, M., Hanzawa, H. 2.15 X-RAY DIFFRACTION 0.258 0.193 False True IGHV3 IGLV1 Lambda None None None None None 4r96 H L 0 Immune System 09/03/14 Structure of a Llama Glama Fab 48A2 against human cMet LLAMA GLAMA lama glama lama glama Klarenbeek, A., El Mazouari, K., Desmyter, A., Blanchetot, C., Hultberg, A., Roovers, R.C., Cambillau, C., Spinelli, S., Del-Favero, J., Verrips, T., de Haard, H., Achour, I. 3.31 X-RAY DIFFRACTION 0.261 0.217 False True IGHV1 IGKV4 Kappa None None None None None 4zyp D E 0 C protein fusion glycoprotein f0,fibritin IMMUNE SYSTEM 05/21/15 Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 5.5 X-RAY DIFFRACTION 0.277 0.211 False True IGHV3 IGKV1 Kappa None None None None None 3u2s H L 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 10/04/11 Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 McLellan, J.S., Pancera, M., Kwong, P.D. 1.797 X-RAY DIFFRACTION 0.205 0.178 False True IGHV3 IGLV2 Lambda None None None None None 6bkd H L 0 E protein polyprotein IMMUNE SYSTEM 11/08/17 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3D RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1; HOMO SAPIENS homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 3.25 X-RAY DIFFRACTION 0.286 0.268 False True IGHV1 IGKV3 Kappa 1.13e-07 -9.477296673074429 BLI TBD 6okq A B 0 IMMUNE SYSTEM 04/14/19 Crystal structure of the SF12 Fab HOMO SAPIENS homo sapiens homo sapiens Barnes, C.O., Bjorkman, P.J. 3.2 X-RAY DIFFRACTION 0.299 0.273 False True IGHV4 IGKV3 Kappa None None None None None 5t78 D C 0 E peptide muc1 glycopeptide IMMUNE SYSTEM 09/02/16 Crystal structure of therapeutic mAB AR20.5 in complex with MUC1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Brooks, C.L., Movahedin, M. 2.2 X-RAY DIFFRACTION 0.221 0.194 False True IGHV5 IGKV1 Kappa 4.3e-08 -10.04974711892974 Unknown TBD 7mf9 M N 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA Fab in space group C2 HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 3.7 X-RAY DIFFRACTION 0.269 0.240 False True IGHV3 IGLV3 Lambda None None None None None 6osy 8 7 0 2 protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-a.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 4.3 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6lra H L 0 C peptide NA vqiink IMMUNE SYSTEM 01/15/20 The complex structure of PHF core domain peptide of tau and antibody's Fab domain. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Tomohiro, T., Kouki, S., Tomohiro, S., Takahiro, T., Katsushiro, M., Yasuko, I., Katsuhiko, M., Taizo, T., Toshimitsu, I., Koji, T. 1.9 X-RAY DIFFRACTION 0.249 0.188 False False IGHV1 IGLV3 Lambda None None None None None 6ca9 B A 0 IMMUNE SYSTEM 01/29/18 Crystal structure of Fab PCT64_LMCA (SAR), the least mutated common ancestor of the HIV-1 broadly neutralizing antibody lineage PCT64 HOMO SAPIENS homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 2.702 X-RAY DIFFRACTION 0.268 0.242 False True IGHV3 IGKV3 Kappa None None None None None 6qn8 J K 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV Fab B13 BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.12 X-RAY DIFFRACTION 0.267 0.235 False True IGHV1 IGLV1 Lambda None None None None None 7kqy D NA 0 NA NA NA NA IMMUNE SYSTEM 11/18/20 Crystal Structure and Characterization of Human Heavy-Chain only Antibodies reveals a novel, stable dimeric structure similar to Monoclonal Antibodies HOMO SAPIENS homo sapiens Bahmanjah, S., Mieczkowski, C., Yu, Y., Baker, J., Raghunathan, G., Tomazela, D., Hsieh, M., Mccoy, M., Strickland, C., Fayadat-Dilman, L. 2.913 X-RAY DIFFRACTION 0.260 0.207 False True IGHV1 NA NA None None None None None 5mu2 M N 0 V peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 4z95 H L 0 IMMUNE SYSTEM/DNA 04/09/15 Fab structure of antibody S1-15 in complex with ssDNA DNA, 5'-5(dT)-p-3' MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.79 X-RAY DIFFRACTION 0.236 0.203 False False IGHV10 IGKV10 Kappa None None None None None 5oca H L 0 B | A protein | protein NA | NA proprotein convertase subtilisin/kexin type 9 | proprotein convertase subtilisin/kexin type 9 HYDROLASE 06/30/17 PCSK9:Fab Complex with Dextran Sulfate HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Thirup, S.S., Vilstrup, J.P. 2.3 X-RAY DIFFRACTION 0.195 0.167 False True IGHV3 IGLV1 Lambda None None None None None 3p0v I M 0 IMMUNE SYSTEM 09/29/10 anti-EGFR/HER3 Fab DL11 alone HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Shia, S. 2.85 X-RAY DIFFRACTION 0.280 0.227 False True IGHV3 IGKV1 Kappa None None None None None 43c9 B A 0 IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY MUS MUSCULUS mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.2 X-RAY DIFFRACTION 0.265 0.210 False True IGHV2 IGKV8 Kappa None None None None None 3chn C O 3 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7eam C D 0 B protein NA spike protein s1 VIRAL PROTEIN, IMMUNE SYSTEM 03/07/21 immune complex of SARS-CoV-2 RBD and cross-neutralizing antibody 7D6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Li, T.T., Gu, Y., Li, S.W. 1.4 X-RAY DIFFRACTION 0.182 0.172 False False IGHV14 IGKV12 Kappa None None None None None 7rr0 B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 08/08/21 SARS-CoV-2 receptor binding domain bound to Fab PDI 222 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Glukhova, A., Black, K.A., Tham, W.H. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6o42 B A 0 I peptide mper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/27/19 Crystal structure of the germline PGZL1 (PGZL1_gVmDmJ) Fab in complex with MPER peptide epitope. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.310 0.257 False True IGHV1 IGKV3 Kappa None None None None None 5y9f b a 0 I protein NA major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 6f7t H L 0 C peptide ribonuclease y IMMUNE SYSTEM 12/11/17 Crystal Structure of an Fab fragment in complex with a peptide from Bacillus subtilis RNase Y MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus bacillus subtilis Golinelli-Pimpaneau, B., Hardouin, P. 2.6 X-RAY DIFFRACTION 0.253 0.202 False False IGHV9 IGLV3 Lambda 3.6e-10 -12.883508495506627 Unknown TBD 6iec F G 0 E protein nsmgngc STRUCTURAL PROTEIN/IMMUNE SYSTEM 04/10/19 Structure of RVFV Gn and human monoclonal antibody R17 RIFT VALLEY FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens rift valley fever virus Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F. 3.2 X-RAY DIFFRACTION 0.281 0.241 False True IGHV3 IGLV3 Lambda None None None None None 7cx3 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/01/20 Cryo-EM structure of the Taprenepag-bound EP2-Gs complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Qu, C., Mao, C., Xiao, P., Shen, Q., Zhong, Y., Yang, F., Shen, D., Tao, X., Zhang, H., Yan, X., Zhao, R., He, J., Guan, Y., Zhang, C., Hou, G., Zhang, P., Yu, X., Guan, Y., Sun, J., Zhang, Y. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7l2c C D 0 B protein NA spike glycoprotein IMMUNE SYSTEM/Viral Protein 12/16/20 Crystallographic structure of neutralizing antibody 2-51 in complex with SARS-CoV-2 spike N-terminal domain (NTD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Reddem, E.R., Shapiro, L. 3.65 X-RAY DIFFRACTION 0.272 0.216 False True IGHV1 IGLV2 Lambda None None None None None 2r2e B A 0 A Hapten KDE PROP-2-EN-1-YL 3-DEOXY-BETA-L-GULO-OCT-2-ULOPYRANOSIDONIC ACID IMMUNE SYSTEM 08/24/07 Crystal structure of S25-2 Fab in complex with Kdo analogues MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 2.4 X-RAY DIFFRACTION 0.306 0.243 False False IGHV7 IGKV8 Kappa None None None None None 6vrp B b 0 NA NA NA NA PROTEIN BINDING 02/08/20 Reverse Transcriptase Diabody with R83T Mutation HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 1.6 X-RAY DIFFRACTION 0.183 0.146 True True unknown unknown unknown None None None None None 2mkw NA A 10 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 7e3c B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/21 SARS-CoV-2 spike in complex with the Ab1 neutralizing antibody (focused refinement on Fab-RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, C. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7k4n F G 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/15/20 SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4lsr H L 0 G protein envelope glycoprotein gp120 with loop d and v5 from strainker_2018_11 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E stran 93TH057 gp120 with LOOP D and Loop V5 from clade A strain KER_2018_11 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.28 X-RAY DIFFRACTION 0.258 0.194 False True unknown IGKV1 Kappa None None None None None 1bog B A 0 C peptide peptide COMPLEX (ANTIBODY/PEPTIDE) 08/04/98 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-HOMOLOGOUS PEPTIDE MUS MUSCULUS mus musculus mus musculus Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J., Hoehne, W. 2.6 X-RAY DIFFRACTION 0.307 0.246 False False IGHV1 IGKV14 Kappa None None None None None 7cvt C D 0 A protein NA h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 08/27/20 Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment ESCHERICHIA COLI MS 198-1; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 198-1 Park, K., Mersch, K., Robertson, J., Lim, H.-H. 2.9 X-RAY DIFFRACTION 0.241 0.201 False True IGHV4 IGKV4 Kappa None None None None None 3cx5 J K 0 E protein cytochrome b-c1 complex subunit rieske, mitochondrial OXIDOREDUCTASE 04/23/08 Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Solmaz, S.R.N., Hunte, C. 1.9 X-RAY DIFFRACTION 0.263 0.245 False True IGHV3 IGKV10 Kappa None None None None None 7kej G J 0 A protein NA virion spike glycoprotein VIRAL PROTEIN/Immune System 10/11/20 BDBV-289 bound to EBOV GPdMuc Makona EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 7lde I i 0 C protein NA glutamate receptor 1 MEMBRANE PROTEIN 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7dzy M N 0 C protein NA spike glycoprotein VIRAL PROTEIN 01/26/21 Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 2490 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Y., Soh, W.T., Li, S., Kishikawa, J., Hirose, M., Kato, T., Standley, D., Okada, M., Arase, H. 3.6 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV3 IGKV3 Kappa None None None None None 5tp3 B NA 0 IMMUNE SYSTEM 10/19/16 Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4 LAMA GLAMA lama glama Wrapp, D., Gilman, M.S.A., McLellan, J.S. 1.874 X-RAY DIFFRACTION 0.208 0.170 False True IGHV1 None None None None None 7e5y H L 0 R protein NA spike protein s1 VIRAL PROTEIN 02/21/21 Molecular basis for neutralizing antibody 2B11 targeting SARS-CoV-2 RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wu, H., Yu, F., Wang, Q.S., Zhou, H., Wang, W.W., Zhao, T., Pan, Y.B., Yang, X.M. 3.59 X-RAY DIFFRACTION 0.277 0.232 False True IGHV3 IGLV1 Lambda None None None None None 4cni A B 0 D protein interleukin-6 01/22/14 Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A. 2.2 X-RAY DIFFRACTION 0.21549 0.17608 False True IGHV3 IGKV1 Kappa 1e-11 -15.006684983512798 SPR TBD 6osh H L 0 K protein tyrosine-protein kinase transmembrane receptor ror2 IMMUNE SYSTEM 04/01/20 Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2 ORYCTOLAGUS CUNICULUS; HOMO SAPIENS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Park, H., Rader, C. 1.117 X-RAY DIFFRACTION 0.169 0.162 False True IGHV1 IGKV1 Kappa None None None None None 5ojm L NA 0 B protein human gabaa receptor chimera beta3-alpha5,gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 07/21/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 SYNTHETIC CONSTRUCT; HOMO SAPIENS; LAMA GLAMA lama glama synthetic construct, homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.3 X-RAY DIFFRACTION 0.250 0.234 False True IGHV1 None None None None None 4jb9 H L 0 G protein clade a/e 93th057 hiv-1 gp120 core viral protein/immune system 02/19/13 Crystal structure of antibody VRC06 in complex with HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Zhou, T., Srivatsan, S., Kwong, P.D. 2.6 X-RAY DIFFRACTION 0.287 0.247 False True IGHV1 IGKV3 Kappa None None None None None 7wly Y X 0 C protein NA spike glycoprotein VIRAL PROTEIN,IMMUNE SYSTEM 01/14/22 Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down- and 2 up RBDs) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 6wj0 H L 0 NA NA NA NA IMMUNE SYSTEM 04/11/20 Crystal structure of Fab 54-4H03 HOMO SAPIENS homo sapiens homo sapiens Wu, N.C., Wilson, I.A. 1.802 X-RAY DIFFRACTION 0.204 0.163 False True IGHV6 IGKV3 Kappa None None None None None 1iqw H L 0 IMMUNE SYSTEM 08/10/01 CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MOUSE ANTI-HUMAN FAS ANTIBODY HFE7A MUS MUSCULUS mus musculus mus musculus Ito, S., Takayama, T., Hanzawa, H., Ichikawa, K., Ohsumi, J., Serizawa, N., Hata, T., Haruyama, H 2.5 X-RAY DIFFRACTION 0.241 0.168 False False IGHV1 IGKV3 Kappa None None None None None 4yga D NA 0 C protein calmodulin-domain protein kinase 1 METAL BINDING PROTEIN 02/26/15 CDPK1, from Toxoplasma gondii, bound to inhibitory VHH-1B7 VICUGNA PACOS; TOXOPLASMA GONDII vicugna pacos toxoplasma gondii Knockenhauer, K.E., Schwartz, T.U. 2.94 X-RAY DIFFRACTION 0.262 0.226 False True IGHV1 None None None None None 5w0k H L 0 A protein envelope glycoprotein h VIRAL PROTEIN/Immune system 05/31/17 Crystal structure of EBV gHgL/CL40/gp42 N-domain HUMAN HERPESVIRUS 4 (STRAIN B95-8); MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human herpesvirus 4 (strain b95-8) Sathiyamoorthy, K., Jardetzky, T.S. 3.1 X-RAY DIFFRACTION 0.299 0.242 False True IGHV1 IGKV6 Kappa 6.880000000000001e-08 -9.771277639060873 SPR TBD 6z7z B A 0 H | G peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Porcine insulin in complex with the analytical antibody OXI-005 Fab MUS MUSCULUS; SUS SCROFA mus musculus mus musculus sus scrofa | sus scrofa Johansson, E. 2.4 X-RAY DIFFRACTION 0.259 0.210 False True IGHV5 IGKV19 Kappa None None None None None 6my5 H L 0 IMMUNE SYSTEM 11/01/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98F,HC-G99M,LC-S30bR] HOMO SAPIENS homo sapiens homo sapiens Shi, R. 1.73 X-RAY DIFFRACTION 0.229 0.186 False True IGHV3 IGKV1 Kappa None None None None None 5owp H h 0 D peptide 5,6-dihydro-benzo[h]cinnolin-3-ylamine IMMUNE SYSTEM 09/02/17 "Crystal structure of glycopeptide """"GVTSAfPDT*RPAP"""" in complex with scFv-SM3" MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus synthetic construct Bermejo, I.A., Albuquerque, I.S., Somovilla, V.J., Martinez-Saez, N., Castro-Lopez, J., Garcia-Martin, F., Hinou, H., Nishimura, S., Jimenez-Barbero, J., Asensio, J.L., Avenoza, A., Busto, J.H., Hurtado-Guerrero, R., Peregrina, J.M., Bernardes, G.J., Corzana, F. 1.85 X-RAY DIFFRACTION 0.256 0.194 True True unknown unknown unknown None None None None None 7k7i J K 0 B protein NA putative pertussis-like toxin subunit TOXIN 09/22/20 Density-fitted Model Structure of Antibody Variable Domains of TyTx4 in Complex with PltB pentamer of Typhoid Toxin SALMONELLA TYPHI; MUS MUSCULUS mus musculus mus musculus salmonella typhi Nguyen, T., Feathers, J.R., Fromme, J.C., Song, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 4jzo D E 0 I peptide envelope glycoprotein e2 immune system/viral protein 04/03/13 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-27 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus (isolate h) Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.236 0.196 False True IGHV1 IGLV3 Lambda None None None None None 7ey4 H L 0 R | N protein | protein NA | NA spike glycoprotein | ntd VIRAL PROTEIN 05/29/21 Local CryoEM of the SARS-CoV-2 S6PV2 in complex with BD-667 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | homo sapiens Liu, P.L. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6pk8 A a 0 NA NA NA NA IMMUNE SYSTEM 06/28/19 Antibody scFv-M204 dimeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 2.91 X-RAY DIFFRACTION 0.238 0.186 True True unknown unknown unknown None None None None None 5n2k B A 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 6ww5 C D 0 B protein NA dass family sodium-coupled anion symporter MEMBRANE PROTEIN 05/07/20 Structure of VcINDY-Na-Fab84 in nanodisc VIBRIO CHOLERAE; HOMO SAPIENS homo sapiens homo sapiens vibrio cholerae Sauer, D.B., Marden, J., Song, J.M., Koide, A., Koide, S., Wang, D.N. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7so9 H G 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.2 delta variant + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5f7k C NA 0 A protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with Nanobody Nb-ER19 HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.17 X-RAY DIFFRACTION 0.207 0.171 False True IGHV1 None None None None None 4rav C D 0 F peptide huntingtin IMMUNE SYSTEM/Apoptosis 09/11/14 Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens De Genst, E., Chirgadze, D.Y., Dobson, C.M. 2.5 X-RAY DIFFRACTION 0.226 0.180 False True IGHV3 IGLV2 Lambda None None None None None 5b71 B A 0 E protein complement c5 beta chain IMMUNE SYSTEM 06/03/16 Crystal structure of complement C5 in complex with SKY59 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irie, M., Shimizu, Y., Sampei, Z., Fukuzawa, T. 2.11 X-RAY DIFFRACTION 0.285 0.246 False True unknown IGKV1 Kappa 1.5200000000000002e-10 -13.394361854051732 SPR TBD 2fjf T S 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 4gqp h H 0 H Hapten B40 (2S)-N-METHYL-1-PHENYLPROPAN-2-AMINE IMMUNE SYSTEM 08/23/12 Structure based design of sub-nanomolar affinity anti-methamphetamine single chain antibodies. MUS MUSCULUS mus musculus mus musculus Thakkar, S., Varughese, K.I. 2.0 X-RAY DIFFRACTION 0.254 0.194 True True unknown unknown unknown 2.5e-10 -13.09955358933185 Unknown TBD 7jwg A B 0 E protein NA outer surface protein a IMMUNE SYSTEM 08/25/20 OspA-Fab 221-7 complex structure HOMO SAPIENS; BORRELIA BURGDORFERI (STRAIN ATCC 35210 / B31 / CIP 102532 / DSM 4680) homo sapiens homo sapiens borrelia burgdorferi (strain atcc 35210 / b31 /cip 102532 / dsm 4680) Rudolph, M.J. 3.05 X-RAY DIFFRACTION 0.306 0.269 False True IGHV5 IGKV1 Kappa None None None None None 7lmn NA A 0 A Hapten NY3 2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl ~{N}-[[3-(1~{H}-imidazol-5-yl)phenyl]methyl]carbamate IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 26 [2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl (3-(1H-imidazol-4-yl)benzyl)carbamate] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.01 X-RAY DIFFRACTION 0.239 0.187 False True NA IGLV6 Lambda None None None None None 3cm9 D O 4 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5mtl NA B 0 IMMUNE SYSTEM 01/10/17 Crystal structure of an amyloidogenic light chain HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.45 X-RAY DIFFRACTION 0.277 0.234 False True IGLV1 Lambda None None None None None 4r7d A B 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 5gs3 A a 0 IMMUNE SYSTEM 08/13/16 Crystal structure of diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 1.698 X-RAY DIFFRACTION 0.211 0.192 True True unknown unknown unknown None None None None None 3j42 I J 0 D protein prm VIRUS/IMMUNE SYSTEM 06/13/13 Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody MUS MUSCULUS; DENGUE VIRUS 2 mus musculus mus musculus dengue virus 2 Wang, Z., Pennington, J.G., Jiang, W., Rossmann, M.G. 21 ELECTRON MICROSCOPY False True IGHV5 IGKV6 Kappa None None None None None 7dk5 a b 0 A protein NA the heavy chain of 2h2 fab VIRAL PROTEIN 11/23/20 S-2H2-F1 structure, one RBD is up and two RBDs are down, only up RBD binds with a 2H2 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 13.5 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 1mvu B A 0 P peptide p-glycoprotein immune system 09/26/02 SINGLE CHAIN FV OF C219 HEAVY CHAIN V101L MUTANT IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Chan, D.C.M., Kuntz, D.A., Rose, D.R. 1.78 X-RAY DIFFRACTION 0.223 0.197 True True IGHV14 IGKV8 Kappa None None None None None 5uk4 l NA 0 L protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 6uva N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/01/19 CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R. 2.3 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6h6y F NA 0 B protein capsid protein vp1 VIRAL PROTEIN 12/19/18 GI.1 human norovirus protruding domain in complex with Nano-7 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Ruoff, K., Hansman, G.S. 1.58 X-RAY DIFFRACTION 0.175 0.155 False True IGHV1 None None None None None 7omm D NA 0 A protein NA lps-assembly protein lptd TRANSPORT PROTEIN 05/24/21 Cryo-EM structure of N. gonorhoeae LptDE in complex with ProMacrobodies (MBPs have not been built de novo) NEISSERIA GONORRHOEAE; SYNTHETIC CONSTRUCT; METHANOSARCINA MAZEI synthetic construct, methanosarcina mazei neisseria gonorrhoeae Botte, M., Ni, D., Schenck, S., Zimmermann, I., Chami, M., Bocquet, N., Egloff, P., Bucher, D., Trabuco, M., Cheng, R.K.Y., Brunner, J.D., Seeger, M.A., Stahlberg, H., Hennig, M. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2ltq C B 4 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 5wkz H L 0 IMMUNE SYSTEM 07/25/17 VH1-69 germline antibody predicted from CR6261 HOMO SAPIENS homo sapiens homo sapiens Lang, S., Lee, P.S. 1.85 X-RAY DIFFRACTION 0.232 0.205 False True IGHV1 IGLV1 Lambda None None None None None 6xud H L 0 NA NA NA NA ANTITUMOR PROTEIN 01/19/20 Apo Ab 1116NS19.9 MUS MUSCULUS mus musculus mus musculus Diskin, R., Borenstein-Katz, A. 1.51 X-RAY DIFFRACTION 0.173 0.147 False True IGHV6 IGKV14 Kappa None None None None None 7ly9 A M 0 K protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/06/21 Cryo-EM structure of 2909 Fab in complex with 3BNC117 Fab and CAP256.wk34.c80 SOSIP.RnS2 N160K HIV-1 Env trimer HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.91 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 7l58 H L 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/21/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab H4 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L. 5.07 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 5jue H L 0 IMMUNE SYSTEM 05/10/16 Crystal Structure of UIC2 Fab MUS MUSCULUS mus musculus mus musculus Xia, D., Esser, L. 1.65 X-RAY DIFFRACTION 0.203 0.165 False True IGHV1 IGKV1 Kappa None None None None None 5id1 D C 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with MPT-Cys meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.49 X-RAY DIFFRACTION 0.221 0.173 False True IGHV2 IGKV5 Kappa 5.6e-07 -8.528997532261052 Unknown TBD 2uzi H L 0 R protein gtpase hras SIGNALING PROTEIN/IMMUNE SYSTEM 04/27/07 Crystal structure of HRAS(G12V) - anti-RAS Fv complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tanaka, T., williams, R.L., Rabbitts, T.H. 2.0 X-RAY DIFFRACTION 0.271 0.194 False True IGHV3 IGKV1 Kappa 6.20e-09 -11.19 SPR 25 17568777 6o3u D C 0 D Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 02/27/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with 06:0 PA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Wilson, I.A. 3.105 X-RAY DIFFRACTION 0.228 0.186 False True IGHV1 IGKV3 Kappa None None None None None 5dsc H L 0 N peptide peptide IMMUNE SYSTEM 09/17/15 Context-independent anti-hypusine antibody FabHpu24.B in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Zhai, Q., Carter, P.J. 2.4 X-RAY DIFFRACTION 0.248 0.207 False True IGHV1 IGKV1 Kappa None None None None None 2xwt A B 0 C protein thyrotropin receptor SIGNALING PROTEIN/IMMUNE SYSTEM 11/05/10 Crystal structure of the TSH receptor in complex with a blocking type TSHR autoantibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sanders, J., Sanders, P., Young, S., Kabelis, K., Baker, S., Sullivan, A., Evans, M., Clark, J., Wilmot, J., Hu, X., Roberts, E., Powell, M., Nunez Miguel, R., Furmaniak, J., Rees Smith, B. 1.9 X-RAY DIFFRACTION 0.22674 0.17691 False True IGHV5 IGLV1 Lambda None None None None None 6db6 H L 0 P peptide hiv-1 gp120 v3 peptide from mn strain IMMUNE SYSTEM 05/02/18 Crystal structure of anti-HIV-1 V3 Fab 311-11D in complex with a HIV-1 gp120 V3 peptide from MN strain HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Chan, K.-W., Kong, X.-P. 1.978 X-RAY DIFFRACTION 0.216 0.174 False True IGHV1 IGLV3 Lambda None None None None None 4hpy H L 0 P peptide envelope glycoprotein gp160 Immune System/Viral Protein 10/24/12 Crystal structure of RV144-elicited antibody CH59 in complex with V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 McLellan, J.S., Gorman, J., Haynes, B.F., Kwong, P.D. 1.5 X-RAY DIFFRACTION 0.187 0.171 False True IGHV3 IGLV3 Lambda 1.2e-10 -13.534418347189932 Unknown TBD 1a6t D C 0 IMMUNOGLOBULIN 03/03/98 FAB FRAGMENT OF MAB1-IA MONOCLONAL ANTIBODY TO HUMAN RHINOVIRUS 14 NIM-IA SITE MUS MUSCULUS mus musculus mus musculus Che, Z., Smith, T.J. 2.7 X-RAY DIFFRACTION 0.266 0.169 False False IGHV1 IGKV4 Kappa None None None None None 7php H L 0 NA NA NA NA MEMBRANE PROTEIN 08/18/21 Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM VIBRIO CHOLERAE RC385; SYNTHETIC CONSTRUCT; LAMA GLAMA synthetic construct synthetic construct Bloch, J.S., Mukherjee, S., Kowal, J., Niederer, M., Pardon, E., Steyaert, J., Kossiakoff, A.A., Locher, K.P. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6yio H L 0 B protein NA interleukin-2 receptor subunit alpha IMMUNE SYSTEM 04/01/20 CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Benz, J., Koll, H., Leibrock, L. 1.83 X-RAY DIFFRACTION 0.231 0.203 False True IGHV1 IGKV1 Kappa None None None None None 7beo C D 0 X protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253H55L and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 3.19 X-RAY DIFFRACTION 0.274 0.234 False True IGHV1 IGKV3 Kappa None None None None None 4tnv V Z 0 R protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False IGHV1 IGLV1 Lambda None None None None None 7e3o H L 0 R protein NA spike protein s1 VIRAL PROTEIN 02/09/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody nCoV617 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, S.D., Yang, M. 2.51 X-RAY DIFFRACTION 0.259 0.204 False True IGHV3 IGLV1 Lambda None None None None None 6vpy A B 0 NA NA NA NA IMMUNE SYSTEM 02/04/20 I33M (I3.2 mutant from CH103 Lineage) HOMO SAPIENS homo sapiens homo sapiens Fera, D., Zhou, J. 2.36 X-RAY DIFFRACTION 0.223 0.185 False True IGHV4 IGLV3 Lambda None None None None None 6ute E F 0 VIRAL PROTEIN 10/29/19 Crystal structure of Z032 Fab in complex with WNV EDIII HOMO SAPIENS; WEST NILE VIRUS homo sapiens homo sapiens Esswein, S.R., Gristick, H.B., Keeffe, J.R., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 5bk1 C D 0 B protein maltose binding protein SUGAR BINDING PROTEIN 09/12/17 Crystal structure of maltose binding protein in complex with an endosteric synthetic antibody HOMO SAPIENS; ESCHERICHIA COLI homo sapiens homo sapiens escherichia coli Mukherjee, S., Kossiakoff, A.A. 2.15 X-RAY DIFFRACTION 0.253 0.205 False True IGHV3 IGKV1 Kappa 1.1000000000000001e-09 -12.22172707862036 SPR TBD 5w9n B C 0 A protein mers s VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 5 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6lml D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/01/20 Cryo-EM structure of the human glucagon receptor in complex with Gi1 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens | homo sapiens Qiao, A., Han, S., Li, X., Sun, F., Zhao, Q., Wu, B. 3.9 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6vo1 H L 0 A protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/29/20 BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5mu0 O P 0 X peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 5w9h B C 0 A protein mers s VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6hug G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 10/08/18 CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38. BOS TAURUS; HOMO SAPIENS; LAMA GLAMA lama glama bos taurus | homo sapiens Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R. 3.1 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 3i50 H L 0 E protein envelope glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/03/09 Crystal structure of the West Nile Virus envelope glycoprotein in complex with the E53 antibody Fab WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Nybakken, G.E., Warren, J.T., Chen, B.R., Nelson, C.A., Fremont, D.H. 3.0 X-RAY DIFFRACTION 0.344 0.247 False True IGHV7 IGKV4 Kappa None None None None None 7lf0 R P 0 M protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6pzg H L 0 IMMUNE SYSTEM 07/31/19 Crystal structure of human NA-80 Fab HOMO SAPIENS homo sapiens homo sapiens Zhu, X., Wilson, I.A. 1.59 X-RAY DIFFRACTION 0.204 0.168 False True IGHV1 IGKV1 Kappa None None None None None 6rpj H NA 0 G protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 05/14/19 A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4 HOMO SAPIENS; CAMELUS BACTRIANUS camelus bactrianus homo sapiens Gao, H., Zhou, A., Zhang, F. 3.25 X-RAY DIFFRACTION 0.262 0.249 False True IGHV1 NA NA None None None None None 1oax NA M 0 IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with acenaphthenequinone RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.67 X-RAY DIFFRACTION 0.282 0.238 False True unknown unknown unknown None None None None None 7ch5 H L 0 R protein NA spike glycoprotein PROTEIN BINDING/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 2.7 X-RAY DIFFRACTION 0.260 0.227 False True IGHV3 IGKV3 Kappa None None None None None 4eig B NA 0 A protein dihydrofolate reductase OXIDOREDUCTASE/IMMUNE SYSTEM 04/05/12 CA1698 camel antibody fragment in complex with DHFR ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Oyen, D., Srinivasan, V. 2.5 X-RAY DIFFRACTION 0.220 0.172 False True IGHV1 1e-09 -12.27819680469229 SPR TBD 2kqn NA A 0 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7ul4 D NA 0 A protein NA mu-type opioid receptor MEMBRANE PROTEIN 04/03/22 CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6 Mus musculus; synthetic construct synthetic construct mus musculus Robertson, M.J., Skiniotis, G. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7q0g A B 0 E protein NA spike protein s1 VIRAL PROTEIN 10/14/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-49 and FI-3A Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 1.82 X-RAY DIFFRACTION 0.224 0.192 False True IGHV1 IGKV3 Kappa None None None None None 3chn B M 2 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7zfb H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.08 X-RAY DIFFRACTION 0.308 0.261 False True IGHV3 IGLV3 Lambda None None None None None 4at6 E F 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 5f88 D C 0 IMMUNE SYSTEM 12/09/15 Cetuximab Fab in complex with L5Y meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.481 X-RAY DIFFRACTION 0.217 0.163 False True IGHV2 IGKV5 Kappa None None None None None 5nuz A B 0 C protein pre-glycoprotein polyprotein gp complex IMMUNE SYSTEM 05/03/17 Junin virus GP1 glycoprotein in complex with an antibody Fab fragment MUS MUSCULUS; JUNIN MAMMARENAVIRUS mus musculus mus musculus junin mammarenavirus Zeltina, A., Krumm, S.A., Sahin, M., Struwe, W.B., Harlos, K., Nunberg, J.H., Crispin, M., Pinschewer, D.D., Doores, K.J., Bowden, T.A. 1.85 X-RAY DIFFRACTION 0.210 0.185 False True IGHV1 IGKV3 Kappa None None None None None 2fec J O 0 A protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 12/15/05 Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C. 3.967 X-RAY DIFFRACTION 0.326 0.269 False True IGHV3 IGKV6D Kappa None None None None None 6mg4 NA B 0 IMMUNE SYSTEM 04/10/19 Structure of full-length human lambda-6A light chain JTO HOMO SAPIENS homo sapiens Morgan, G.J., Yan, N.L., Mortenson, D.E., Stanfield, R.L., Wilson, I.A., Kelly, J.W. 1.75 X-RAY DIFFRACTION 0.221 0.171 False True IGLV6 Lambda None None None None None 6qfa M NA 0 D protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 01/09/19 CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 HOMO SAPIENS; HELICOBACTER PYLORI (STRAIN G27); LAMA GLAMA helicobacter pylori (strain g27), lama glama homo sapiens Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkoening, A., Zoegg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6mnr H L 0 P peptide envelope glycoprotein IMMUNE SYSTEM 10/02/18 Rhesus macaque anti-HIV V3 antibody DH753 with gp120 V3 ZAM18 peptide MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Nicely, N.I. 2.201 X-RAY DIFFRACTION 0.255 0.192 False True IGHV3 IGLV1 Lambda None None None None None 1kxq E NA 0 D protein alpha-amylase, pancreatic HYDROLASE, IMMUNE SYSTEM 02/01/02 Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase CAMELUS DROMEDARIUS; SUS SCROFA camelus dromedarius sus scrofa Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C. 1.6 X-RAY DIFFRACTION 0.219 0.197 False True IGHV1 3.50e-09 -11.53 SPR 11960990 5j3d A B 0 F | E protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 IMMUNE SYSTEM 03/30/16 Crystal structure of human Fab 14N4 in complex with post-fusion RSV F HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A homo sapiens homo sapiens human respiratory syncytial virus a | human respiratory syncytial virus a Mousa, J.J., Crowe, J.E. 4.077 X-RAY DIFFRACTION 0.282 0.257 False True IGHV3 IGKV1 Kappa None None None None None 3cm9 B M 8 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6fxn Q R 0 K protein tumor necrosis factor ligand superfamily member 13b IMMUNE SYSTEM 03/09/18 Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lammens, A., Maskos, K., Willen, L., Jiang, X., Schneider, P. 2.9 X-RAY DIFFRACTION 0.231 0.191 False True IGHV1 IGLV3 Lambda None None None None None 6n1w 3 4 0 A protein envelope glycoprotein gp41 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody DFPH-a.15 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV4 IGKV1 Kappa None None None None None 3utz F E 0 IMMUNE SYSTEM 11/27/11 Endogenous-like inhibitory antibodies targeting activated metalloproteinase motifs show therapeutic potential MUS MUSCULUS Sela-Passwell, N., Kikkeri, R, Dym, O., Rozenberg, H, Margalit, R, Arad-Yellin, R., Eisenstein, M., Brenner, O., Shoham, T., Danon, T., Shanzer, A., Sagi, I., Israel Structural Proteomics Center (ISPC) 2.18 X-RAY DIFFRACTION 0.288 0.228 False True IGHV5 IGKV1 Kappa None None None None None 7pi3 D E 0 A protein NA monoclonal antibody cy.004 heavy chain IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 7ul7 G F 0 b protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 04/04/22 Lineage I (Pinneo) Lassa virus glycoprotein bound to 18.5C-M30 Fab LASSA MAMMARENAVIRUS; HOMO SAPIENS homo sapiens homo sapiens lassa mammarenavirus Buck, T.K., Enriquez, A.S., Hastie, K.M. 3.59 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6nc3 S X 0 N | G protein | protein NA | NA hiv-1 env amc011 v4.2 sosip gp41 | hiv-1 env amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Torres, J.L., Ward, A.B. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 1n4x I M 0 Immune system 11/02/02 Structure of scFv 1696 at acidic pH MUS MUSCULUS mus musculus mus musculus Lescar, J., Brynda, J., Fabry, M., Horejsi, M., Rezacova, P., Sedlacek, J., Bentley, G.A. 1.7 X-RAY DIFFRACTION 0.256 0.227 False True IGHV9 IGKV1 Kappa None None None None None 6ugu H L 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a C-centered orthorhombic crystal form, Lot C HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H.D. 2.2 X-RAY DIFFRACTION 0.219 0.170 False True IGHV6 IGKV5 Kappa None None None None None 3dwt A NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 6gjs B NA 0 A protein cystic fibrosis transmembrane conductance regulator IMMUNE SYSTEM 05/16/18 Human NBD1 of CFTR in complex with nanobodies D12 and T4 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 1.95 X-RAY DIFFRACTION 0.212 0.177 False True IGHV1 None None None None None 6yz5 F NA 0 E protein spike glycoprotein VIRAL PROTEIN 06/03/20 H11-D4 complex with SARS-CoV-2 RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Naismith, J.H., Huo, J., Mikolajek, H., Ward, P., Dumoux, M., Owens, R.J., Le Bas, A. 1.8 X-RAY DIFFRACTION 0.193 0.166 False True IGHV1 None None None None None 4r8w H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 09/03/14 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a neutralizing antibody CT149 INFLUENZA A VIRUS (A/ANHUI/1-BALF_RG45/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1-balf_rg45/2013(h7n9)) | influenza a virus (a/anhui/1-balf_rg45/2013(h7n9)) Wu, Y., Shi, Y., Qi, J., Gao, G.F. 2.795 X-RAY DIFFRACTION 0.311 0.262 False True IGHV1 IGKV3 Kappa 1.8300000000000001e-10 -13.284393546178524 SPR TBD 5y9k H L 0 PROTEIN BINDING 08/25/17 Structure of the belimumab Fab fragment HOMO SAPIENS homo sapiens homo sapiens Heo, Y.-S., Shin, W. 1.9 X-RAY DIFFRACTION 0.206 0.167 False True IGHV1 IGLV3 Lambda None None None None None 6ug9 J K 0 K carbohydrate GAL polysaccharide IMMUNE SYSTEM 09/26/19 Complex of ch28/11 Fab and SSEA-4 (hexagonal form) MUS MUSCULUS mus musculus mus musculus mus musculus Soliman, C., Ramsland, P.A. 2.74 X-RAY DIFFRACTION 0.247 0.170 False True IGHV2 IGKV4 Kappa None None None None None 5kan J K 0 F | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.g.07 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.785 X-RAY DIFFRACTION 0.243 0.218 False True IGHV1 IGKV1 Kappa None None None None None 7lkb B C 0 D peptide NA circumsporozoite protein IMMUNE SYSTEM/ANTIGEN 02/02/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.127 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Xu, K., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.217 0.181 False True IGHV1 IGKV4 Kappa None None None None None 6au5 B A 0 IMMUNE SYSTEM 08/30/17 Structure of cetuximab with aminoheptanoic acid-linked n-butylarginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.484 X-RAY DIFFRACTION 0.227 0.186 False True IGHV2 IGKV5 Kappa 2.7e-06 -7.5969790708218685 Unknown TBD 6vjt H L 0 P peptide NA antigenic region 139-148 of hepatitis b surface antigenprotein ANTIVIRAL PROTEIN/IMMUNE SYSTEM 01/17/20 Co-crystals of broadly neutralizing antibody with the linear epitope from Hepatitis B surface antigen HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis b virus Oren, D.A., Nussenzweig, M.C., Wang, Q. 1.782 X-RAY DIFFRACTION 0.227 0.182 False True IGHV3 IGKV1 Kappa None None None None None 7bbj H L 0 A protein NA 5'-nucleotidase IMMUNE SYSTEM 12/17/20 CD73 in complex with the humanized antagonistic antibody mAb19 HOMO SAPIENS; UNIDENTIFIED unidentified unidentified homo sapiens Boettcher, J., Han, F. 2.72 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 IGKV1 Kappa None None None None None 7swn H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 11/20/21 G32A4 Fab in complex with SARS-CoV-2 Spike 6P (RBD local reconstruction) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Windsor, I.W., Tong, P., Wesemann, D.R., Harrison, S.C. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1mak NA A 13 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5h2b A B 0 IMMUNE SYSTEM 10/14/16 Structure of a novel antibody G196 MUS MUSCULUS mus musculus mus musculus Park, S.Y., Sugiyama, K. 2.001 X-RAY DIFFRACTION 0.281 0.211 False False IGHV1 IGKV6 Kappa None None None None None 5iq9 A B 0 C peptide gp41 mper peptide IMMUNE SYSTEM 03/10/16 Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Kwon, Y.D., Caruso, W., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.236 0.191 False True IGHV3 IGLV3 Lambda None None None None None 7mw4 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3upc F NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 7dge D NA 0 B protein NA metabotropic glutamate receptor 1 MEMBRANE PROTEIN 11/11/20 intermediate state of class C GPCR HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Zhang, J.Y., Wu, L.J., Luo, F., Hua, T., Liu, Z.J. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3det E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 06/10/08 Structure of the E418A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Jayaram, H., Accardi, A., Wu, F., Williams, C., Miller, C. 2.8 X-RAY DIFFRACTION 0.299 0.255 False False IGHV4 IGKV4 Kappa None None None None None 1y18 H L 0 H Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/17/04 Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.8 X-RAY DIFFRACTION 0.252 0.215 False True IGHV4 IGLV1 Lambda None None None None None 2qtj B M 1 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7mw4 D E 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6cuf 5 6 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 5ysl A B 0 IMMUNE SYSTEM 11/14/17 Crystal structure of antibody 1H1 Fab MUS MUSCULUS mus musculus mus musculus Hu, X.L., Yang, F.L. 2.5 X-RAY DIFFRACTION 0.273 0.212 False True IGHV1 IGKV4 Kappa None None None None None 7omt A NA 0 NA NA NA NA IMMUNE SYSTEM 05/24/21 Crystal structure of ProMacrobody 21 with bound maltose SYNTHETIC CONSTRUCT synthetic construct Botte, M., Ni, D., Schenck, S., Zimmermann, I., Chami, M., Bocquet, N., Egloff, P., Bucher, D., Trabuco, M., Cheng, R.K.Y., Brunner, J.D., Seeger, M.A., Stahlberg, H., Hennig, M. 2.0 X-RAY DIFFRACTION 0.239 0.193 False True IGHV1 NA NA None None None None None 6n5b H L 0 B protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/21/18 Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Bajic, G., Maron, M.J., Schmidt, A.G. 3.5 X-RAY DIFFRACTION 0.278 0.236 False True IGHV5 IGLV1 Lambda None None None None None 4unt NA A 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 7uel H L 0 NA NA NA NA IMMUNE SYSTEM 03/22/22 Genetic and structural basis for the human anti-alpha-galactosyl antibody response Homo sapiens homo sapiens homo sapiens Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.216 0.169 False True IGHV3 IGLV2 Lambda None None None None None 7n8h J I 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/14/21 SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5vsh H L 0 IMMUNE SYSTEM 05/11/17 CH1/Clambda Fab based on Pertuzumab HOMO SAPIENS homo sapiens homo sapiens Hendle, J. 2.55 X-RAY DIFFRACTION 0.255 0.207 False True IGHV3 IGKV1 Kappa None None None None None 2brr Y X 0 P peptide class 1 outer membrane protein variable region 2 IMMUNE SYSTEM 05/11/05 Complex of the neisserial PorA P1.4 epitope peptide and two Fab- fragments (antibody MN20B9.34) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Oomen, C.J., Hoogerhout, P., Kuipers, B., Vidarsson, G., vanAlphen, L., Gros, P. 1.95 X-RAY DIFFRACTION 0.238 0.198 False True IGHV9 IGKV4 Kappa None None None None None 6fys A NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 7k8s M N 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Malyutin, A.G., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6her B NA 0 A protein major prion protein PROTEIN BINDING 08/20/18 Mouse prion protein in complex with Nanobody 484 MUS MUSCULUS; CAMELUS DROMEDARIUS camelus dromedarius mus musculus Soror, S.H., Abskharon, R., Wohlkonig, A. 1.199 X-RAY DIFFRACTION 0.195 0.169 False True IGHV1 None None None None None 2y6s D C 0 P peptide envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/25/11 Structure of an Ebolavirus-protective antibody in complex with its mucin-domain linear epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus zaire ebolavirus Olal, D.O., Kuehne, A., Lee, J.E., Bale, S., Dye, J.M., Saphire, E.O. 2.8 X-RAY DIFFRACTION 0.2873 0.2359 False False IGHV1 IGKV3 Kappa 1.0300000000000001e-07 -9.532195517943316 Unknown TBD 5w24 H L 0 IMMUNE SYSTEM 06/05/17 Crystal Structure of 5C4 Fab MUS MUSCULUS mus musculus mus musculus Battles, M.B., McLellan, J.S., Taher, N.M. 1.5 X-RAY DIFFRACTION 0.203 0.170 False True IGHV14 IGKV3 Kappa None None None None None 1mfe H L 0 H carbohydrate GLA polysaccharide IMMUNOGLOBULIN 10/25/93 RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus mus musculus Cygler, M. 2.0 X-RAY DIFFRACTION unknown 0.185 False True IGHV1 IGLV1 Lambda None None None None None 7wi0 H L 0 A protein NA spike protein s1 VIRAL PROTEIN 01/01/22 SARS-CoV-2 Omicron variant spike in complex with three human neutralizing antibodies Homo sapiens homo sapiens homo sapiens homo sapiens Zheng, Q., Li, S., Sun, H., Zheng, Z., Wang, S. 3.82 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7qna N NA 0 E | D protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6ayn D C 0 IMMUNE SYSTEM 09/08/17 Structure of cetuximab with aminoheptanoic acid-linked N-(3-aminopropyl)-L-arginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.222 0.172 False True IGHV2 IGKV5 Kappa 9.199999999999998e-06 -6.870622689559801 Unknown TBD 7r87 C D 0 B | A protein | protein NA | NA atp-binding cassette sub-family g member 8 | atp-binding cassette sub-family g member 5 LIPID TRANSPORT/IMMUNE SYSTEM 06/26/21 The structure of human ABCG5-WT/ABCG8-I419E HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Sun, Y., Li, X., Long, T. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV9 Kappa None None None None None 2f19 H L 0 IMMUNOGLOBULIN 05/27/92 THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY MUS MUSCULUS mus musculus mus musculus Lascombe, M.B., Alzari, P.M., Poljak, R.J., Nisonoff, A. 2.8 X-RAY DIFFRACTION unknown 0.182 False True IGHV1 IGKV10 Kappa None None None None None 6c9w B NA 0 A protein lactose permease MEMBRANE PROTEIN 01/29/18 Crystal Structure of a ligand bound LacY/Nanobody Complex ESCHERICHIA COLI (STRAIN K12); LAMA GLAMA lama glama escherichia coli (strain k12) Kumar, H., Finer-Moore, J.S., Jiang, X., Smirnova, I., Kasho, V., Pardon, E., Steyaert, J., Kaback, H.R., Stroud, R.M. 3.0 X-RAY DIFFRACTION 0.295 0.276 False True IGHV1 None None None None None 7cn2 K k 0 C protein NA major capsid protein l1 IMMUNE SYSTEM/VIRAL PROTEIN 07/29/20 Subparticle refinement of human papillomavirus type 16 pesudovirus in complex with H16.001 Fab HUMAN PAPILLOMAVIRUS TYPE 16; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human papillomavirus type 16 He, M.Z., Li, S.W. 3.43 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 2xa3 A NA 0 IMMUNE SYSTEM 03/29/10 crystal structure of the broadly neutralizing llama VHH D7 and its mode of HIV-1 gp120 interaction LAMA GLAMA lama glama Hinz, A., LutjeHulsik, D., Forsman, A., Koh, W., Belrhali, H., Gorlani, A., deHaard, H., Weiss, R.A., Verrips, T., Weissenhorn, W. 1.5 X-RAY DIFFRACTION 0.1935 0.1657 False True IGHV1 None None None None None 7f16 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 06/08/21 Cryo-EM structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and G protein HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; LAMA GLAMA lama glama homo sapiens | rattus norvegicus Wang, X., Cheng, X., Zhao, L.H., Wang, Y., Ye, C., Zou, X., Dai, A., Cong, Z., Chen, J., Zhou, Q., Xia, T., Jiang, H., Xu, H.E., Yang, D., Wang, M.W. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1vhp A NA 14 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7kd6 C D 0 E protein NA insulin receptor subunit alpha SIGNALING PROTEIN 10/08/20 Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G. 2.6 X-RAY DIFFRACTION 0.221 0.189 False True IGHV2 IGKV8 Kappa None None None None None 5grx H h 0 IMMUNE SYSTEM 08/12/16 Crystal structure of disulfide-bonded diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.002 X-RAY DIFFRACTION 0.215 0.167 True True unknown unknown unknown None None None None None 1rz7 H L 0 IMMUNE SYSTEM 12/24/03 CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 IGKV1 Kappa None None None None None 6lxj J K 0 C protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9) INFLUENZA A VIRUS (A/ANHUI/1-BALF_RG44/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/anhui/1-balf_rg44/2013(h7n9)) Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 2.903 X-RAY DIFFRACTION 0.241 0.193 False True IGHV1 IGLV2 Lambda None None None None None 7t01 H L 0 A protein NA spike protein s1 VIRAL PROTEIN 11/29/21 SARS-CoV-2 S-RBD + Fab 54042-4 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Johnson, N.V., Mclellan, J.S. 2.69 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV1 Kappa None None None None None 2r69 H L 0 A protein major envelope protein e viral protein/Immune system 09/05/07 Crystal structure of Fab 1A1D-2 complexed with E-DIII of Dengue virus at 3.8 angstrom resolution DENGUE VIRUS 2 THAILAND/16681/84; MUS MUSCULUS mus musculus mus musculus dengue virus 2 thailand/16681/84 Lok, S.M., Kostyuchenko, V.K., Nybakken, G.E., Holdaway,H.A, Battisti, A.J., Sukupolvi-petty, S., Sedlak, D., Fremont, D.H., Chipman, P.R., Roehrig, J.T., Diamond, M.S., Kuhn, R.J., Rossmann, M.G. 3.8 X-RAY DIFFRACTION 0.363 0.313 False True IGHV14 IGKV3 Kappa None None None None None 6cwk A NA 0 IMMUNE SYSTEM 03/30/18 Anti-RTA VHH antibody VICUGNA PACOS vicugna pacos Rudolph, M.J., Mantis, N. 1.256 X-RAY DIFFRACTION 0.176 0.155 False True IGHV1 None None None None None 3q6g H L 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of rhesus mAb 2.5B specific for quaternary neutralizing epitope of HIV-1 gp120 MACACA MULATTA macaca mulatta macaca mulatta Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 1.902 X-RAY DIFFRACTION 0.231 0.191 False False IGHV4 IGLV3 Lambda None None None None None 6xul A B 0 NA NA NA NA ANTITUMOR PROTEIN 01/20/20 Apo Ab 5b1 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.230 0.168 False True IGHV3 IGLV1 Lambda None None None None None 6xjy H L 0 A nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - short time incubation with the epoxide substrate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 2.156 X-RAY DIFFRACTION 0.285 0.227 False True IGHV3 IGKV1 Kappa None None None None None 6e8v H L 0 IMMUNE SYSTEM 09/04/19 The crystal structure of bovine ultralong antibody BOV-1 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 3.79 X-RAY DIFFRACTION 0.275 0.218 False True IGHV1 IGLV1 Lambda None None None None None 7phv B C 0 A protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/18/21 PfCyRPA bound to monoclonal antibody Cy.007 Fab fragment PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.091 X-RAY DIFFRACTION 0.332 0.287 False True unknown unknown unknown None None None None None 5utz B C 0 A protein interleukin-2 CYTOKINE/IMMUNE SYSTEM 02/15/17 Human IL-2/Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Jude, K.M., Garcia, K.C. 2.747 X-RAY DIFFRACTION 0.248 0.193 False True IGHV4 IGLV6 Lambda 1.879e-09 -11.904493814008964 SPR TBD 6wgk G H 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.62 X-RAY DIFFRACTION 0.236 0.210 False True IGHV3 IGKV2 Kappa None None None None None 7k37 H G 0 A | B protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 7.8 INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Xiang, Y., Gao, J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6n16 C D 0 I peptide hiv fusion peptide (512-519) IMMUNE SYSTEM 11/08/18 Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-b.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.302 X-RAY DIFFRACTION 0.274 0.222 False True IGHV4 IGKV2 Kappa None None None None None 5gry G g 0 IMMUNE SYSTEM 08/12/16 Crystal structure of disulfide-bonded diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 1.639 X-RAY DIFFRACTION 0.231 0.198 True True unknown unknown unknown None None None None None 5xp1 NA D 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 7mfg H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 04/09/21 Cryo-EM structure of the VRC310 clinical trial, vaccine-elicited, human antibody 310-030-1D06 Fab in complex with an H1 NC99 HA trimer INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Gorman, J., Kwong, P.D. 3.87 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2ny2 D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (T123C, T257S, S334A, S375W, G431C) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.223 0.194 False True IGHV1 IGKV3 Kappa 1.23e-07 SPR 17301785 6k67 NA A 0 B protein engineered calmodulin STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (9011-3LRH) HOMO SAPIENS homo sapiens homo sapiens Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.95 X-RAY DIFFRACTION 0.237 0.203 False True IGLV1 Lambda None None None None None 2wzp E NA 0 A protein putative receptor binding protein VIRAL PROTEIN 12/01/09 Structures of Lactococcal Phage p2 Baseplate Shed Light on a Novel Mechanism of Host Attachment and Activation in Siphoviridae LACTOCOCCUS PHAGE P2; LAMA GLAMA lama glama lactococcus phage p2 Sciara, G., Bebeacua, C., Bron, P., Tremblay, D., Ortiz-Lombardia, M., Lichiere, J., van Heel, M., Campanacci, V., Moineau, S., Cambillau, C. 2.6 X-RAY DIFFRACTION 0.2078 0.1789 False True IGHV1 None None None None None 3lex A B 0 C peptide envelope glycoprotein gp41 IMMUNE SYSTEM 01/15/10 2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D. 1.97 X-RAY DIFFRACTION 0.198 0.165 False False IGHV3 IGKV1 Kappa None None None None None 2omn NA A 0 Immune system 01/22/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P4(3)2(1)2 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.2 X-RAY DIFFRACTION 0.283 0.226 False False IGLV2 Lambda None None None None None 4xp1 H L 0 A protein dopamine transporter, isoform b membrane protein/transport protein 01/16/15 X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Gouaux, E., Penmatsa, A., Wang, K. 2.89 X-RAY DIFFRACTION 0.256 0.218 False True IGHV5 IGKV4 Kappa None None None None None 4dk3 B NA 0 D protein rna-editing complex protein mp81 RNA BINDING PROTEIN/IMMUNE SYSTEM 02/03/12 Structure of Editosome protein LAMA GLAMA; TRYPANOSOMA BRUCEI lama trypanosoma brucei Park, Y.-J., Hol, W. 2.76 X-RAY DIFFRACTION 0.267 0.224 False True IGHV1 None None None None None 4tnv F N 0 B protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False IGHV1 IGLV1 Lambda None None None None None 2r0k H L 0 A protein hepatocyte growth factor activator HYDROLASE, IMMUNE SYSTEM 08/20/07 Protease domain of HGFA with inhibitor Fab58 HOMO SAPIENS homo sapiens Eigenbrot, C., Shia, S. 3.51 X-RAY DIFFRACTION 0.312 0.251 False True IGHV3 IGKV1 Kappa 6.00e-10 -12.57 SPR 25 18077410 7tuz E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 IMMUNE SYSTEM 02/03/22 Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Chen, H., Hung, W., Li, X. 3.12 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7eq3 A a 0 NA NA NA NA IMMUNE SYSTEM 04/29/21 Apo diabody form of CRH2-directed antibody 9F8 MUS MUSCULUS mus musculus Yan, L. 2.87 X-RAY DIFFRACTION 0.247 0.238 True True unknown unknown unknown None None None None None 6srx H L 0 PROTEIN BINDING 09/06/19 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021158 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 1.9 X-RAY DIFFRACTION 0.261 0.234 False False IGHV3 IGLV1 Lambda None None None None None 6wtv K L 0 J protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 258259 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.05 X-RAY DIFFRACTION 0.277 0.235 False True IGHV3 IGLV3 Lambda None None None None None 6cwd E e 0 F protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/30/18 Hepatitis B core-antigen in complex with scFv e13 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS GENOTYPE D SUBTYPE ADW oryctolagus cuniculus hepatitis b virus genotype d subtype adw Eren, E., Steven, A.C., Wingfield, P.T. 3.33 X-RAY DIFFRACTION 0.282 0.242 True True unknown unknown unknown None None None None None 6njl K J 0 D protein glutamate receptor 2 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.7 ELECTRON MICROSCOPY False True IGHV2 IGKV10 Kappa None None None None None 7nmu D NA 0 B protein NA unknown BLOOD CLOTTING 02/23/21 Crystal structure of human platelet glycoprotein VI in complex with an inhibitory nanobody. HOMO SAPIENS; LAMA GLAMA Slater, A., Jonas, E., Watson, S.P. 2.5 X-RAY DIFFRACTION 0.235 0.174 False False IGHV1 NA NA None None None None None 6rah C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing open conformation THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 2.8 ELECTRON MICROSCOPY False True IGHV1 None None None None None 5w0d B C 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 05/30/17 Inferred precursor (UCA) of the human antibody lineage K03.12 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) McCarthy, K.R., Harrison, S.C. 1.899 X-RAY DIFFRACTION 0.234 0.196 False True IGHV1 IGLV2 Lambda None None None None None 7czx J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B9 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV4 Kappa None None None None None 4qxt A B 0 Q peptide merozoite surface antigen 2 IMMUNE SYSTEM 07/22/14 Crystal Structure of anti-MSP2 Fv fragment (mAb6D8)in complex with FC27-MSP2 14-30 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum k1 Morales, R.A.V., MacRaild, C.A., Seow, J., Bankala, K., Drinkwater, N., McGowan, S., Rouet, R., Christ, D., Anders, R.F., Norton, R.S. 1.58 X-RAY DIFFRACTION 0.177 0.156 False True IGHV14 IGKV3 Kappa 1.6e-08 -10.635483235413165 Unknown TBD 7pnm H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/07/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 46C12 antibody Fab fragment HUMAN CORONAVIRUS OC43; HOMO SAPIENS homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7e3b B C 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/21 SARS-Cov-2 spike in complex with the Ab5 neutralizing antibody (focused refinement on Fab-RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, C. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 4hf5 H L 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 10/04/12 Crystal structure of Fab 8F8 in complex a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.004 X-RAY DIFFRACTION 0.282 0.229 False True IGHV3 IGLV1 Lambda None None None None None 7b09 H L 0 A protein NA envelope polyprotein VIRUS LIKE PARTICLE 11/19/20 Puumala virus glycoprotein (Gc) in complex with fab fragment P-4G2. MYODES GLAREOLUS; PUUMALA ORTHOHANTAVIRUS myodes glareolus myodes glareolus puumala orthohantavirus Rissanen, I., Stass, R., Huiskonen, J.T., Bowden, T.A. 13.4 ELECTRON MICROSCOPY NA NA False True IGHV5 unknown unknown None None None None None 7k9i H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/29/20 SARS-CoV-2 Spike RBD in complex with neutralizing Fab 2B04 (local refinement) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Errico, J.M., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.3 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 5lmj C NA 0 IMMUNE SYSTEM 08/01/16 Llama nanobody PorM_19 LAMA GLAMA lama glama Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.210 0.188 False True IGHV1 None None None None None 7m8j H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/29/21 SARS-CoV-2 S-NTD + Fab CM25 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Johnson, N.V., Mclellan, J.S. 3.48 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 2uyl N M 0 IMMUNE SYSTEM 04/10/07 Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1 MUS MUSCULUS mus musculus mus musculus Ahmed, F., Haouz, A., Nato, F., Fournier, J.M., Alzari, P.M. 2.5 X-RAY DIFFRACTION 0.257 0.211 False False IGHV1 IGKV1 Kappa None None None None None 7lf2 O M 0 R protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5d71 H L 0 A protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 08/13/15 Crystal structure of MOR04302, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M. 2.25 X-RAY DIFFRACTION 0.219 0.180 False True IGHV3 IGLV3 Lambda 6.5e-11 -13.897672741510132 Unknown TBD 6veq C D 0 E protein insulin receptor subunit alpha TOXIN 06/03/20 Con-Ins G1 in complex with the human insulin microreceptor in turn in complex with Fv 83-7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Menting, J.G., Chou, D.H.-C., Lawrence, M.C., Xiong, X. 3.25 X-RAY DIFFRACTION 0.277 0.228 False True IGHV2 IGKV8 Kappa None None None None None 7m7g E F 0 A protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 chimera BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7so9 O N 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.2 delta variant + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7k75 I J 0 F peptide NA pfcsp n-terminal peptide p17 IMMUNE SYSTEM 09/22/20 Crystal structure of MAD2-6 IgA Fab in complex with PfCSP N-terminal peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.192 False True IGHV4 IGKV1 Kappa None None None None None 2xkn B A 0 IMMUNE SYSTEM 07/09/10 Crystal structure of the Fab fragment of the anti-EGFR antibody 7A7 MUS MUSCULUS mus musculus mus musculus Talavera, A., Mackenzie, J., Friemann, R., Garrido, G., Lopez-Requena, A., Moreno, E., Krengel, U. 1.4 X-RAY DIFFRACTION 0.1765 0.1438 False False IGHV5 IGKV10 Kappa None None None None None 4ocn F NA 0 E | D protein | protein NA | NA 26s proteasome regulatory subunit rpn11 | 26s proteasome regulatory subunit rpn8 HYDROLASE, PROTEIN BINDING 01/09/14 Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form II SACCHAROMYCES CEREVISIAE; LAMA GLAMA lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Pathare, G.R., Bracher, A. 2.25 X-RAY DIFFRACTION 0.281 0.232 False True IGHV1 NA NA None None None None None 4fqq D C 0 IMMUNE SYSTEM 06/25/12 Crystal Structure of Germline Antibody PGT121-GL Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 2.42 X-RAY DIFFRACTION 0.237 0.194 False True IGHV4 IGLV3 Lambda None None None None None 4fqj H L 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Influenza B/Florida/4/2006 hemagglutinin Fab CR8071 complex INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dreyfus, C., Laursen, N.S., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.265 0.230 False True IGHV1 IGLV1 Lambda 9.000000000000001e-10 -12.340621190735936 BLI TBD 7kn5 D NA 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobodies VHH E and U SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 1.87 X-RAY DIFFRACTION 0.213 0.177 False True IGHV1 NA NA None None None None None 4zpt A B 0 R protein spike glycoprotein Viral protein/Immune system 05/08/15 Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 1) HUMAN CORONAVIRUS EMC (ISOLATE UNITED KINGDOM/H123990006/2012); MUS MUSCULUS mus musculus mus musculus human coronavirus emc (isolate unitedkingdom/h123990006/2012) Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 2.591 X-RAY DIFFRACTION 0.244 0.204 False False IGHV5 IGKV10 Kappa 9.93e-09 -10.91811468499047 BLI TBD 6ev1 E F 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Dubel, S., Blankenfeldt, W., Rau, U. 3.043 X-RAY DIFFRACTION 0.238 0.186 False True IGHV1 IGKV4 Kappa None None None None None 6b5l H L 0 A peptide pfcsp peptide 20 IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 20 with human protective antibody CIS43 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 2.4 X-RAY DIFFRACTION 0.238 0.199 False True IGHV1 IGKV4 Kappa None None None None None 6wyr I M 0 NA NA NA NA IMMUNE SYSTEM 05/13/20 Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1A HOMO SAPIENS homo sapiens homo sapiens Vieni, C., Ekiert, D. 1.8 X-RAY DIFFRACTION 0.214 0.180 False True IGHV1 IGLV3 Lambda None None None None None 2kqm NA A 14 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1qgc A 4 0 5 | 1 | 3 peptide | protein | protein NA | NA | NA protein (gh-loop from virus capsid protein vp1) | protein (virus capsid protein vp1) | protein (virus capsid protein vp3) Virus/Immune system 04/23/99 STRUCTURE OF THE COMPLEX OF A FAB FRAGMENT OF A NEUTRALIZING ANTIBODY WITH FOOT AND MOUTH DISEASE VIRUS FOOT-AND-MOUTH DISEASE VIRUS - TYPE C; MUS MUSCULUS mus musculus mus musculus foot-and-mouth disease virus - type c | foot-and-mouth disease virus - type c | foot-and-mouth disease virus - type c Fita, I. 30.0 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 5i1d H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV4-1 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.0 X-RAY DIFFRACTION 0.251 0.216 False True IGHV3 IGKV4 Kappa None None None None None 6tnp H L 0 H unknown NO8 unknown IMMUNE SYSTEM 12/09/19 Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide MUS MUSCULUS mus musculus mus musculus mus musculus Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. 3.0 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV8 Kappa None None None None None 6ulc H L 0 A | E protein | protein NA | NA envelope glycoprotein gp120,envelope glycoprotein gp120 | envelope glycoprotein gp120,envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/07/19 Structure of full-length, fully glycosylated, non-modified HIV-1 gp160 bound to PG16 Fab at a nominal resolution of 4.6 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Pan, J., Chen, B., Harrison, S.C. 4.6 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 5viy M N 0 A protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 6.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5u3l A B 0 C peptide gp41 mper peptide IMMUNE SYSTEM/VIRAL PROTEIN 12/02/16 Crystal Structure of DH511.2 Fab in Complex with HIV-1 gp41 MPER 670-683 Peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Wu, L., Lougheed, C.S., Williams, L.D., Nicely, N.I., Haynes, B.F. 2.165 X-RAY DIFFRACTION 0.231 0.205 False True IGHV3 IGKV1 Kappa None None None None None 1a7p H L 0 IMMUNOGLOBULIN 03/16/98 FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) ENGINEERED MUTANT PRO95L->SER ON VARIANT CHAIN L GLU81->ASP AND CHAIN H LEU312->VAL MUS MUSCULUS mus musculus mus musculus Marks, C., Henrick, K., Winter, G. 2.01 X-RAY DIFFRACTION unknown 0.174 False True IGHV2 IGKV12 Kappa None None None None None 4ma8 H L 0 C protein major prion protein IMMUNE SYSTEM 08/15/13 Crystal structure of mouse prion protein complexed with Chlorpromazine MUS MUSCULUS mus musculus mus musculus mus musculus Baral, P.K., Swayampakula, M., James, M.N.G. 2.2 X-RAY DIFFRACTION 0.236 0.195 False True IGHV1 IGKV5 Kappa None None None None None 7kpj C D 0 F protein NA gram_pos_anchoring domain-containing protein IMMUNE SYSTEM 11/11/20 Crystal structure of Ruminococcus gnavus immunoglobulin binding protein in complex with 338E6 Fab MUS MUSCULUS; RUMINOCOCCUS GNAVUS mus musculus mus musculus ruminococcus gnavus Borowska, M.T., Adams, E.J. 2.1 X-RAY DIFFRACTION 0.266 0.229 False True IGHV5 IGKV6 Kappa None None None None None 6u14 A NA 0 IMMUNE SYSTEM 08/15/19 VHH R303 C33A/C102A in complex withthe LRR domain of InlB CAMELUS DROMEDARIUS camelus dromedarius Mendoza, M.N., Jian, M., Toride King, M., Brooks, C.L. 1.3 X-RAY DIFFRACTION 0.179 0.159 False True IGHV1 None None None None None 7mf9 Q R 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA Fab in space group C2 HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 3.7 X-RAY DIFFRACTION 0.269 0.240 False True IGHV3 IGLV3 Lambda None None None None None 6woz B C 0 A protein NA reticulocyte binding protein 2b CELL INVASION 04/26/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 251249 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.9 X-RAY DIFFRACTION 0.258 0.211 False True IGHV3 IGKV3 Kappa None None None None None 6e56 G I 0 D protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/19/18 Human antibody H2214 in complex with influenza hemagglutinin A/Aichi/2/1968 (X-31) (H3N2) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus McCarthy, K.R., Harrison, S.C. 2.0 X-RAY DIFFRACTION 0.214 0.188 False True IGHV3 IGKV3 Kappa None None None None None 7mnm H L 0 A protein NA e3 sumo-protein ligase ranbp2 TRANSPORT PROTEIN/Immune System 05/01/21 Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T585M mutant in complex with Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Dasso, M., Patke, A., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A. 4.7 X-RAY DIFFRACTION 0.254 0.204 False True IGHV3 IGKV1 Kappa None None None None None 6uqr A a 0 B protein ige IMMUNE SYSTEM 10/21/19 Complex of IgE and Ligelizumab HOMO SAPIENS homo sapiens homo sapiens Tarchevskaya, S.S., Kleinboelting, S., Jardetzky, T.S. 3.65029 X-RAY DIFFRACTION 0.295 0.290 True True unknown unknown unknown None None None None None 7kqe I N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 11/15/20 SARS-CoV-2 spike glycoprotein:Fab 3D11 complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Asarnow, D., Charles, C., Cheng, Y. 2.88 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV6 Lambda None None None None None 4oaw D C 0 IMMUNE SYSTEM 01/06/14 Fab structure of anti-HIV gp120 V2 mAb 2158 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B.R., Kong, X.P. 2.8 X-RAY DIFFRACTION 0.254 0.182 False True IGHV1 IGKV1 Kappa None None None None None 4xtr E F 0 A protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/23/15 Structure of Get3 bound to the transmembrane domain of Pep12 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (strain atcc 204508 /s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.05 X-RAY DIFFRACTION 0.216 0.187 False True IGHV3 IGKV1 Kappa None None None None None 6cwd A a 0 C protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/30/18 Hepatitis B core-antigen in complex with scFv e13 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS GENOTYPE D SUBTYPE ADW oryctolagus cuniculus hepatitis b virus genotype d subtype adw Eren, E., Steven, A.C., Wingfield, P.T. 3.33 X-RAY DIFFRACTION 0.282 0.242 True True unknown unknown unknown None None None None None 4kkl C D 0 A protein h(+)/cl(-) exchange transporter clca tranport protein, membrane protein 05/06/13 Structure of the E148A mutant of CLC-ec1 delta NC construct in 100mM fluoride MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Stockbridge, R.B., Lim, H.-H., Miller, C. 2.85 X-RAY DIFFRACTION 0.290 0.248 False True IGHV4 IGKV4 Kappa None None None None None 4u1g B C 0 A protein reticulocyte binding protein 5 IMMUNE SYSTEM 07/15/14 Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody QA1 PLASMODIUM FALCIPARUM; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus plasmodium falciparum Wright, K.E., Hjerrild, K.A., Bartlett, J., Douglas, A.D., Jin, J., Brown, R.E., Ashfield, R., Clemmensen, S.B., de Jongh, W.A., Draper, S.J., Higgins, M.K. 3.1 X-RAY DIFFRACTION 0.281 0.236 False True IGHV5 IGKV3 Kappa None None None None None 6bt3 D C 0 M protein NA major capsid protein l1 VIRUS 12/05/17 High-Resolution Structure Analysis of Antibody V5 Conformational Epitope on Human Papillomavirus 16 MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 Guan, J., Bywaters, S.M., Brendle, S.A., Ashley, R.E., Makhov, A.M., Conway, J.F., Christensen, N.D., Hafenstein, S. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 4q2z A B 0 IMMUNE SYSTEM 04/10/14 Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE356, from a non-human primate MACACA MULATTA macaca mulatta macaca mulatta Navis, M., Tran, K., Bale, S., Phad, G., Guenaga, J., Wilson, R., Soldemo, M., McKee, K., Sundling, C., Mascola, J., Li, Y., Wyatt, R.T., Hedestam, G.B.K. 1.93 X-RAY DIFFRACTION 0.272 0.232 False True IGHV1 IGLV1 Lambda None None None None None 7o3b B NA 0 H protein NA tau-tubulin kinase 2,centrosomal protein of 164 kda STRUCTURAL PROTEIN 04/01/21 Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody CAMELIDAE MIXED LIBRARY; HOMO SAPIENS camelidae mixed library homo sapiens e Silva, I.R., van Breugel, M. 2.4 X-RAY DIFFRACTION 0.240 0.189 False True IGHV1 NA NA None None None None None 5yd3 E e 0 F peptide epitope peptide IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.184 0.136 True True unknown unknown unknown None None None None None 6al0 H L 0 A protein pdz tandem fragment with pa tag insertion SIGNALING PROTEIN 09/05/18 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA12 tag inserted between the residues 263 and 267 AQUIFEX AEOLICUS; AQUIFEX AEOLICUS (STRAIN VF5); RATTUS NORVEGICUS rattus norvegicus rattus norvegicus aquifex aeolicus, aquifex aeolicus (strainvf5) Tamura, R., Oi, R., Kaneko, M.K., Kato, Y., Nogi, T. 2.6 X-RAY DIFFRACTION 0.251 0.199 False True IGHV5 IGLV3 Lambda None None None None None 3j2y B A 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab 9.8B MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 14.9 ELECTRON MICROSCOPY False False IGHV1 IGKV4 Kappa None None None None None 6v8z J K 0 G protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 2.9 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 7zmp K NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-055 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.626 X-RAY DIFFRACTION 0.359 0.332 False True IGHV1 NA NA None None None None None 1maj NA A 5 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7cz0 H NA 0 D protein NA thermostable green fluorescent protein (tgp) FLUORESCENT PROTEIN 09/06/20 Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb92) GALAXEA FASCICULARIS; SYNTHETIC CONSTRUCT synthetic construct galaxea fascicularis Cai, H., Yao, H., Li, T., Hutter, C., Tang, Y., Li, Y., Seeger, M., Li, D. 2.77 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 NA NA None None None None None 6o89 NA L 0 NA NA NA NA IMMUNE SYSTEM 03/09/19 Anti-CD28xCD3 CODV Fab HOMO SAPIENS homo sapiens Lord, D.M., Wei, R.R. 2.09 X-RAY DIFFRACTION 0.222 0.178 False True NA IGKV15 Kappa None None None None None 5ezo H L 0 A protein uncharacterized protein IMMUNE SYSTEM 11/26/15 Crystal Structure of PfCyRPA PLASMODIUM FALCIPARUM (ISOLATE 3D7); MUS MUSCULUS; HOMO SAPIENS homo sapiens mus musculus plasmodium falciparum (isolate 3d7) Favuzza, P., Pluschke, G., Rudolph, M.G. 3.63 X-RAY DIFFRACTION 0.330 0.274 False True IGHV4 IGKV6 Kappa None None None None None 3cm9 A L 4 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5th9 H L 0 A protein matrix metalloproteinase-9,matrix metalloproteinase-9 hydrolase/hydrolase inhibitor 09/29/16 Structure determination of a potent, selective antibody inhibitor of human MMP9 (GS-5745 bound to MMP-9) ORYCTOLAGUS CUNICULUS; HOMO SAPIENS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Appleby, T.C., Greenstein, A.E., Kwon, H.J. 2.999 X-RAY DIFFRACTION 0.257 0.218 False True IGHV2 IGKV6 Kappa None None None None None 5lwf C NA 0 A protein beta-lactamase HYDROLASE 09/16/16 Structure of a single domain camelid antibody fragment cAb-G10S in complex with the BlaP beta-lactamase from Bacillus licheniformis BACILLUS LICHENIFORMIS; LAMA GLAMA lama glama bacillus licheniformis Vettore, N., Kerff, F., Pain, C., Herman, R., Sauvage, E., Preumont, S., Charlier, P., Dumoulin, M. 2.56 X-RAY DIFFRACTION 0.242 0.215 False True IGHV1 None None None None None 1cfv H L 0 H Hapten E3G ESTRONE BETA-D-GLUCURONIDE IMMUNOGLOBULIN 04/11/97 MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI MUS MUSCULUS mus musculus mus musculus mus musculus Trinh, C.H., Phillips, S.E.V. 2.1 X-RAY DIFFRACTION 0.247 0.178 False True IGHV5 IGKV1 Kappa None None None None None 6pci J M 0 C protein NA virion spike glycoprotein immune system, viral protein 06/17/19 EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus Ward, A.B., Murin, C.D., Alkutkar, T. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5y2k C D 0 IMMUNE SYSTEM 07/26/17 A human antibody AF4H1L1 HOMO SAPIENS homo sapiens homo sapiens Xiao, H., Qi, J., Gao, F.G. 2.1 X-RAY DIFFRACTION 0.259 0.220 False True IGHV3 IGLV3 Lambda None None None None None 7oay H NA 0 G protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 2.34 X-RAY DIFFRACTION 0.228 0.192 False False IGHV1 NA NA None None None None None 2ltq F E 6 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 6vbp H L 0 G peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH815 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.298 X-RAY DIFFRACTION 0.229 0.180 False True IGHV5 IGKV4 Kappa None None None None None 4jzo A B 0 J peptide envelope glycoprotein e2 immune system/viral protein 04/03/13 Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-27 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus (isolate h) Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.236 0.196 False True IGHV1 IGLV3 Lambda None None None None None 7nqa D NA 0 A protein NA nuclear pore complex protein nup96 NUCLEAR PROTEIN 03/01/21 Complex of Nucleoporin-98 and nanobody MS98-27 solved at 1.85A resolution XENOPUS TROPICALIS; VICUGNA PACOS vicugna pacos xenopus tropicalis Sola-Colom, M., Trakhanov, S., Goerlich, D. 2.2 X-RAY DIFFRACTION 0.226 0.176 False True IGHV1 NA NA None None None None None 7vsw F E 0 NA NA NA NA BIOSYNTHETIC PROTEIN 10/27/21 Crystal structure of a Fab-like fragment of anti-mesothelin antibody HOMO SAPIENS homo sapiens homo sapiens Yang, Z., Ying, T. 3.0 X-RAY DIFFRACTION 0.253 0.217 False True IGHV4 IGKV1 Kappa None None None None None 7keo A B 0 D | C protein | protein NA | NA ubiquitin | ubiquitin PROTEIN BINDING 10/11/20 Crystal structure of K29-linked di-ubiquitin in complex with synthetic antigen binding fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Yu, Y., Zheng, Q., Erramilli, S., Pan, M., Kossiakoff, A., Liu, L., Zhao, M. 2.9 X-RAY DIFFRACTION 0.282 0.236 False True IGHV3 IGKV1 Kappa None None None None None 6srv I M 0 NA NA NA NA PROTEIN BINDING 09/06/19 Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021144 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 2.4 X-RAY DIFFRACTION 0.241 0.205 False False IGHV3 IGLV1 Lambda None None None None None 1dee D C 0 G protein immunoglobulin g binding protein a IMMUNE SYSTEM 11/15/99 CRYSTAL STRUCTURE AT 2.7A RESOLUTION OF A COMPLEX BETWEEN A STAPHYLOCOCCUS AUREUS DOMAIN AND A FAB FRAGMENT OF A HUMAN IGM ANTIBODY STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus Graille, M., Stura, E.A., Corper, A.L., Sutton, B.J., Taussig, M.J., Charbonnier, J.B., Silverman, G.J. 2.7 X-RAY DIFFRACTION 0.281 0.217 False False IGHV3 IGKV1 Kappa 4e-07 -8.728351841232218 Unknown TBD 7z1c B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-B5 and H11-F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 1.9 X-RAY DIFFRACTION 0.199 0.175 False True IGHV1 NA NA None None None None None 5k9q X Y 0 R protein NA hemagglutinin ha2 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.503 X-RAY DIFFRACTION 0.218 0.182 False True IGHV1 IGKV1 Kappa None None None None None 6dc3 H L 0 F protein rsv fusion glycoprotein IMMUNE SYSTEM 05/04/18 RSV prefusion F bound to RSD5 Fab HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HUMAN IMMUNODEFICIENCY VIRUS 1; UNIDENTIFIED homo sapiens homo sapiens human respiratory syncytial virus a (straina2), human immunodeficiency virus 1, unidentified Battles, M.B., McLellan, J.S., Jones, H.J. 3.501 X-RAY DIFFRACTION 0.205 0.183 False True IGHV3 IGLV2 Lambda None None None None None 3chn C O 5 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 1eeq NA A 0 IMMUNE SYSTEM 02/01/00 M4L/Y(27D)D/T94H Mutant of LEN HOMO SAPIENS homo sapiens Pokkuluri, P.R., Raffen, R., Dieckman, L., Boogaard, C., Stevens, F.J., Schiffer, M. 1.5 X-RAY DIFFRACTION 0.238 0.211 False True IGKV4 Kappa None None None None None 1a7q H L 0 IMMUNOGLOBULIN 03/16/98 FV FRAGMENT OF MOUSE MONOCLONAL ANTIBODY D1.3 (BALB/C, IGG1, K) HIGH AFFINITY EXPRESSED VARIANT CONTAINING SER26L->GLY, ILE29L->THR, GLU81L->ASP, THR97L->SER, PRO240H->LEU, ASP258H->ALA, LYS281H->GLU, ASN283H->ASP AND LEU312H->VAL MUS MUSCULUS mus musculus mus musculus Marks, C., Henrick, K., Winter, G. 2.0 X-RAY DIFFRACTION unknown 0.178 False True IGHV2 IGKV12 Kappa None None None None None 4wfg E D 0 A protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a Tl+ bound conductive conformation MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 3.0 X-RAY DIFFRACTION 0.236 0.202 False True IGHV1 IGKV4 Kappa None None None None None 6obc B NA 0 A protein NA ricin a chain TOXIN 03/20/19 Ricin A chain bound to camelid RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.762 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 NA NA None None None None None 7u0d O P 0 B protein NA surface glycoprotein Vral Protein/IMMUNE SYSTEM 02/17/22 Local refinement of cryo-EM structure of the interface of the Omicron RBD in complex with antibodies B-182.1 and A19-46.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., kwong, P.D. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6wzm C D 0 F protein NA interleukin-8 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Durbin, J.D., Druzina, Z. 2.28 X-RAY DIFFRACTION 0.229 0.187 False True IGHV1 IGKV3 Kappa None None None None None 6cnv H L 0 B protein envelope glycoprotein VIRAL PROTEIN 03/09/18 INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX INFLUENZA B VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SYNTHETIC CONSTRUCT; HOMO SAPIENS homo sapiens homo sapiens influenza b virus, human immunodeficiency virus1 Luo, J., Obmolova, G. 4.1 X-RAY DIFFRACTION 0.276 0.241 False True IGHV1 IGLV1 Lambda None None None None None 6vbg D NA 0 B protein NA galactoside permease PROTEIN TRANSPORT 12/18/19 Lactose permease complex with thiodigalactoside and nanobody 9043 ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Kumar, H., Stroud, R.M., Kaback, H.R., Finer-Moore, J., Smirnova, I., Kasho, V., Pardon, E., Steyart, J. 2.8 X-RAY DIFFRACTION 0.275 0.239 False True IGHV1 NA NA None None None None None 7zfe Y NA 0 C protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV1 NA NA None None None None None 6ikm F f 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 5u4r A B 0 IMMUNE SYSTEM 12/05/16 Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 53-1A09 Fab. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Andrews, S.F., Mascola, J.R., McDermott, A.B., Kwong, P.D. 1.762 X-RAY DIFFRACTION 0.204 0.177 False True IGHV3 IGKV1 Kappa None None None None None 5usf C NA 0 B protein tyrosyl-trna synthetase, putative ligase/ligase inhibitor 02/13/17 Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor LAMA GLAMA; LEISHMANIA DONOVANI (STRAIN BPK282A1) lama glama leishmania donovani (strain bpk282a1) Barros-Alvarez, X., Hol, W.G.J. 2.75 X-RAY DIFFRACTION 0.244 0.189 False True IGHV3 None None None None None 6hjp G H 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/04/18 Structure of Influenza Hemagglutinin ectodomain (A/duck/Alberta/35/76) in complex with FISW84 Fab Fragment HOMO SAPIENS; INFLUENZA A VIRUS (STRAIN A/DUCK/ALBERTA/35/1976 H1N1) homo sapiens homo sapiens influenza a virus (straina/duck/alberta/35/1976 h1n1) | influenza a virus (straina/duck/alberta/35/1976 h1n1) Benton, D.J., Rosenthal, P.B. 3.3 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 3k2u H L 0 A protein hepatocyte growth factor activator long chain HYDROLASE/IMMUNE SYSTEM 09/30/09 Crystal structure of HGFA in complex with the allosteric inhibitory antibody Fab40 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Ganesan, R., Eigenbrot, C., Shia, S. 2.35 X-RAY DIFFRACTION 0.290 0.239 False True IGHV3 IGKV1 Kappa 1.60e-10 -13.36 SPR 25 20004165 3v0v A B 0 IMMUNE SYSTEM 12/08/11 Fab WN1 222-5 unliganded MUS MUSCULUS mus musculus mus musculus Gomery, K., Evans, S.V. 2.13 X-RAY DIFFRACTION 0.284 0.238 False False IGHV7 IGKV11 Kappa None None None None None 4dn3 H L 0 IMMUNE SYSTEM 02/08/12 Crystal structure of anti-mcp-1 antibody cnto888 HOMO SAPIENS homo sapiens homo sapiens Obmolova, G., Teplyakov, A., Malia, T., Grygiel, T., Sweet, R., Snyder L., Gilliland, G. 2.6 X-RAY DIFFRACTION 0.249 0.191 False True IGHV1 IGKV3 Kappa None None None None None 3a67 H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 08/24/09 Crystal Structure of HyHEL-10 Fv mutant LN31D complexed with hen egg white lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Yokota, A., Tsumoto, K., Shiroishi, M., Nakanishi, T., Kondo, H., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.225 0.189 False True IGHV3 IGKV5 Kappa 5.62e-09 -11.44 ITC 30 20038580 3t0x NA B 0 A Hapten DIW 1-(3-SULFOPROPYL)-4-[(1E,3E)-3-(1,3,3-TRIMETHYL-1,3-DIHYDRO-2H-INDOL-2-YLIDENE)PROP-1-EN-1-YL]QUINOLINIUM DYE-BINDING PROTEIN 07/20/11 Fluorogen Activating Protein M8VLA4(S55P) in complex with dimethylindole red HOMO SAPIENS homo sapiens homo sapiens Stanfield, R., Senutovitch, N., Bhattacharyya, S., Rule, G., Wilson, I.A., Armitage, B., Waggoner, A.S., Berget, P. 1.96 X-RAY DIFFRACTION 0.242 0.209 False True IGLV1 Lambda 1e-08 -10.913952715282035 Unknown TBD 6x1s A B 0 K peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC1-1) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 1.65 X-RAY DIFFRACTION 0.226 0.200 False True IGHV1 IGKV1 Kappa None None None None None 6gv1 H L 0 A protein major facilitator superfamily multidrug/h+ antiporter mdfafrom e.coli TRANSPORT PROTEIN 06/20/18 Crystal structure of E.coli Multidrug/H+ antiporter MdfA in outward open conformation with bound Fab fragment ESCHERICHIA COLI K-12; MUS MUSCULUS mus musculus mus musculus escherichia coli k-12 Nagarathinam, K., Parthier, C., Stubbs, M.T., Tanabe, M. 3.4 X-RAY DIFFRACTION 0.283 0.258 False True IGHV2 IGKV9 Kappa None None None None None 2b2x I M 0 B protein integrin alpha-1 Immune system 09/19/05 VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Clark, L.A., Boriack-Sjodin, P.A., Eldredge, J., Fitch, C., Friedman, B., Hanf, K.J., Jarpe, M., Liparoto, S.F., Li, Y., Lugovskoy, A. 2.2 X-RAY DIFFRACTION 0.272 0.238 False True IGHV5 IGKV4 Kappa 1.72e-09 -11.95 Other 16597831 5fhx NA L 0 IMMUNE SYSTEM 12/22/15 CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION. HOMO SAPIENS homo sapiens Vallee, F., Dupuy, A., Rak, A. 2.55 X-RAY DIFFRACTION 0.249 0.184 False True IGKV11 Kappa 1.2e-11 -14.898662436600187 SPR TBD 2vit B A 0 C protein hemagglutinin COMPLEX (HEMAGGLUTININ/IMMUNOGLOBULIN) 12/22/97 INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Bizebard, T., Fleury, D., Gigant, B., Wharton, S.A., Skehel, J.J., Knossow, M. 3.25 X-RAY DIFFRACTION 0.237 0.188 False False IGHV2 IGLV1 Lambda None None None None None 7buf H L 0 A protein dengue virus serotype 2 e protein VIRUS 05/13/20 Cryo-EM structure of Dengue virus serotype 2 complexed with SIgN-3C IgG HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 6.1 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5y2k A B 0 IMMUNE SYSTEM 07/26/17 A human antibody AF4H1L1 HOMO SAPIENS homo sapiens homo sapiens Xiao, H., Qi, J., Gao, F.G. 2.1 X-RAY DIFFRACTION 0.259 0.220 False True IGHV3 IGLV3 Lambda None None None None None 4ncc 2 1 0 IMMUNE SYSTEM 10/24/13 Neutralizing antibody to murine norovirus MUS MUSCULUS mus musculus mus musculus Smith, T., Li, M. 2.49 X-RAY DIFFRACTION 0.273 0.204 False False IGHV4 IGKV4 Kappa None None None None None 7lki A B 0 C peptide NA unknown VIRUS 02/02/21 The crystal structure of Epitope III of HCV envelop protein E2 in complex with antibody 1H8 MUS MUSCULUS; HEPACIVIRUS C Deng, L., Zhang, P. 2.0 X-RAY DIFFRACTION 0.294 0.245 False False IGHV6 IGKV1 Kappa None None None None None 7s0d M N 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-014 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5mp5 H L 0 J peptide microtubule-associated protein tau IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M. 2.31 X-RAY DIFFRACTION 0.277 0.235 False False IGHV1 IGKV8 Kappa None None None None None 1fpt H L 0 P peptide fab fragment of an neutralizing antibody for type 1poliovirus COMPLEX (ANTIBODY/PV-1 FRAGMENT) 01/26/95 THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE HUMAN POLIOVIRUS 1; MUS MUSCULUS mus musculus mus musculus human poliovirus 1 Wien, M.W., Hogle, J.M. 3.0 X-RAY DIFFRACTION unknown 0.230 False True IGHV1 IGKV1 Kappa None None None None None 6vkn I K 0 D | B protein | protein NA | NA envelope glycoprotein gp160 | bg505 sosipv5.2 gp41 VIRAL PROTEIN/Immune System 01/21/20 BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 2ih3 A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 09/25/06 Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Valiyaveetil, F.I., Leonetti, M., Muir, T.W., MacKinnon, R. 1.72 X-RAY DIFFRACTION 0.242 0.233 False False IGHV1 IGKV5 Kappa None None None None None 2z91 A B 0 IMMUNE SYSTEM 09/14/07 Crystal structure of the Fab fragment of anti-ciguatoxin antibody 10C9 MUS MUSCULUS mus musculus mus musculus Ui, M., Tanaka, Y., Tsumoto, K. 2.6 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV4 Kappa None None None None None 6p7h A B 0 C peptide hiv fusion peptide residues (512-519) IMMUNE SYSTEM 06/10/20 Vaccine-elicited NHP FP-targeting neutralizing antibody DF2F-b.04 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 1.782 X-RAY DIFFRACTION 0.230 0.201 False True IGHV4 IGKV2 Kappa None None None None None 7k3b J I 0 C | D protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation C, central helices splay INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5gjt H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 07/01/16 Crystal structure of H1 hemagglutinin from A/Washington/05/2011 in complex with a neutralizing antibody 3E1 HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wang, W., Zhang, T., Ding, J. 3.1 X-RAY DIFFRACTION 0.259 0.216 False True IGHV4 IGKV1 Kappa None None None None None 6bpe B C 0 A protein reticulocyte binding protein 2, putative CELL INVASION 11/22/17 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 6H1 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus mus musculus plasmodium vivax (strain salvador i) Gruszczyk, J., Chan, L.J., Tham, W.H. 3.34 X-RAY DIFFRACTION 0.367 0.318 False False IGHV5 IGKV6 Kappa None None None None None 4x8j A B 0 IMMUNE SYSTEM 12/10/14 Crystal Structure of murine 12F4 Fab monoclonal antibody against ADAMTS5 MUS MUSCULUS mus musculus mus musculus Larkin, J., Lohr, T.A., Elefante, L., Shearin, J., Matico, R., Su, J.-L., Xue, Y., Liu, F., Genell, C., Miller, R.E., Tran, P.B., Malfait, A.-M., Maier, C.C., Matheny, C.J. 2.35 X-RAY DIFFRACTION 0.234 0.217 False True IGHV6 IGKV6 Kappa None None None None None 4k3e H L 0 IMMUNE SYSTEM 04/10/13 Crystal structure of bovine antibody BLV5B8 with ultralong CDR H3 BOS TAURUS bos taurus bos taurus Ekiert, D.C., Wang, F., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.240 0.202 False True IGHV1 IGLV1 Lambda None None None None None 6nf2 V U 0 Q protein envelope glycoprotein gp120 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 2p4a B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Koide, A., Uysal, S., Koide, S. 1.9 X-RAY DIFFRACTION 0.218 0.184 False True IGHV1 1.80e-10 -13.51 Other 30 17888451 4z5r Q P 0 G protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 1n5y H L 0 B protein reverse transcriptase TRANSFERASE/IMMUNE SYSTEM/DNA 11/07/02 HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P) HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, P., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E. 3.1 X-RAY DIFFRACTION 0.285 0.255 False False IGHV8 IGKV10 Kappa None None None None None 6rpj F NA 0 E protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 05/14/19 A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4 HOMO SAPIENS; CAMELUS BACTRIANUS camelus bactrianus homo sapiens Gao, H., Zhou, A., Zhang, F. 3.25 X-RAY DIFFRACTION 0.262 0.249 False True IGHV1 NA NA None None None None None 6kdh H L 0 IMMUNE SYSTEM 07/02/19 Antibody 64M-5 Fab including isoAsp in ligand-free form MUS MUSCULUS mus musculus mus musculus Yokoyama, H., Mizutani, R., Noguchi, S., Hayashida, N. 2.47 X-RAY DIFFRACTION 0.253 0.194 False False IGHV1 IGKV1 Kappa None None None None None 3zdy E F 0 C protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM/PEPTIDE 12/03/12 Integrin alphaIIB beta3 headpiece and RGD peptide complex HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.45 X-RAY DIFFRACTION 0.2156 0.1820 False True IGHV14 IGKV14 Kappa None None None None None 7kmg D E 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/02/20 LY-CoV555 neutralizing antibody against SARS-CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hendle, J., Pustilnik, A., Sauder, J.M., Coleman, K.A., Boyles, J.S., Dickinson, C.D. 2.16 X-RAY DIFFRACTION 0.257 0.209 False True IGHV1 IGKV1 Kappa None None None None None 7oo2 A B 0 NA NA NA NA ANTIMICROBIAL PROTEIN 05/26/21 Crystal structure of an antibody targeting the capsular polysaccharide of serogroup X Neisseria meningitidis (MenX) MUS MUSCULUS mus musculus mus musculus Pietri, G.P., de Ruyck, J., Lenac, T., Adamo, R., Bouckaert, J. 2.16 X-RAY DIFFRACTION 0.262 0.213 False True IGHV2 IGKV17 Kappa None None None None None 1qac NA A 0 IMMUNE SYSTEM 02/25/99 CHANGE IN DIMERIZATION MODE BY REMOVAL OF A SINGLE UNSATISFIED POLAR RESIDUE HOMO SAPIENS homo sapiens Pokkuluri, P.R., Cai, X., Johnson, G., Stevens, F.J., Schiffer, M. 1.8 X-RAY DIFFRACTION 0.226 0.193 False True IGKV4 Kappa None None None None None 1bre NA E 0 IMMUNOGLOBULIN 07/19/95 IMMUNOGLOBULIN LIGHT CHAIN PROTEIN HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 2.0 X-RAY DIFFRACTION 0.337 0.218 False True IGKV1 Kappa None None None None None 6njn O N 0 D protein glutamate receptor 2 MEMBRANE PROTEIN 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.5 ELECTRON MICROSCOPY False True IGHV2 IGKV10 Kappa None None None None None 5kn5 A B 0 C peptide protransforming growth factor alpha IMMUNE SYSTEM 06/27/16 TGFalpha/Epiregulin complex with neutralizing antibody LY3016859 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Atwell, S., Boyles, J.S., Clawson, D.K., Druzina, Z., Josef, G.H., Weichert, K., Witcher, D.R. 2.8 X-RAY DIFFRACTION 0.263 0.206 False True IGHV1 IGKV4 Kappa 1.02e-10 -13.630708160608433 Unknown TBD 5eoc H L 0 P peptide ala-cys-gln-leu-ile-asn-thr-asn-gly-ser-trp-his-ile-cys IMMUNE SYSTEM 11/10/15 Crystal structure of Fab C2 in complex with a Cyclic variant of Hepatitis C Virus E2 epitope I MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Berisio, R., Ruggiero, A., Sandomenico, A., Patel, A.H., Ruvo, M., Vitagliano, L. 1.98 X-RAY DIFFRACTION 0.266 0.234 False False IGHV1 IGKV3 Kappa 3.03e-08 -10.257147454957629 Unknown TBD 1f2x K NA 0 IMMUNE SYSTEM 05/30/00 STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05 CAMELUS DROMEDARIUS camelus dromedarius Decanniere, K., Muyldermans, S., Wyns, L. 2.1 X-RAY DIFFRACTION 0.270 0.190 False True IGHV1 None None None None None 3hnv H L 0 H carbohydrate AXR polysaccharide IMMUNE SYSTEM 06/01/09 CS-35 Fab Complex with Oligoarabinofuranosyl Tetrasaccharide (branch part of Hexasaccharide) MUS MUSCULUS mus musculus mus musculus mus musculus Murase, T., Zheng, R.B., Joe, M., Bai, Y., Marcus, S.L., Lowary, T.L., Ng, K.K.S. 2.0 X-RAY DIFFRACTION 0.230 0.174 False False IGHV1 IGKV10 Kappa None None None None None 2kqn NA A 13 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7dv4 F NA 0 E protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 01/12/21 Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 HOMO SAPIENS homo sapiens homo sapiens Li, H., Gan, X., He, Y. 2.38 X-RAY DIFFRACTION 0.258 0.221 False True IGHV3 NA NA None None None None None 4p3d A B 0 C peptide matrix metalloproteinase-14 IMMUNE SYSTEM 03/07/14 MT1-MMP:Fab complex (Form II) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Rozenberg, H., Udi, Y., Sagi, I. 1.949 X-RAY DIFFRACTION 0.210 0.158 False True IGHV5 IGKV1 Kappa None None None None None 6pe9 A B 0 NA NA NA NA IMMUNE SYSTEM 06/20/19 Crystal Structure of CD40 complexed to FAB516 HOMO SAPIENS homo sapiens homo sapiens Argiriadi, M.A. 3.13 X-RAY DIFFRACTION 0.255 0.216 False True IGHV3 IGKV4 Kappa None None None None None 7n3f H L 0 NA NA NA NA IMMUNE SYSTEM 06/01/21 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment C080 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J., Barnes, C.O. 1.9 X-RAY DIFFRACTION 0.221 0.186 False True IGHV5 IGLV1 Lambda None None None None None 7dfl C c 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/09/20 Cryo-EM structure of histamine H1 receptor Gq complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens He, Y., Xia, R., Wang, N., Xu, Z. 3.3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6orq J K 0 I protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 7wv9 S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-2 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 02/10/22 Cryo-EM structure of human receptor with G proteins HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Qin, J., Cai, Y., Xu, Z., Ming, Q., Ji, S.Y., Wu, C., Zhang, H., Mao, C., Shen, D.D., Hirata, K., Ma, Y., Yan, W., Zhang, Y., Shao, Z. 3.36 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4xtr C D 0 B protein atpase get3 HYDROLASE/TRANSPORT PROTEIN 01/23/15 Structure of Get3 bound to the transmembrane domain of Pep12 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (strain atcc 204508 /s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.05 X-RAY DIFFRACTION 0.216 0.187 False True IGHV3 IGKV1 Kappa None None None None None 7jwg H L 0 C protein NA outer surface protein a IMMUNE SYSTEM 08/25/20 OspA-Fab 221-7 complex structure HOMO SAPIENS; BORRELIA BURGDORFERI (STRAIN ATCC 35210 / B31 / CIP 102532 / DSM 4680) homo sapiens homo sapiens borrelia burgdorferi (strain atcc 35210 / b31 /cip 102532 / dsm 4680) Rudolph, M.J. 3.05 X-RAY DIFFRACTION 0.306 0.269 False True IGHV5 IGKV1 Kappa None None None None None 7n8q H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 06/15/21 Rhesusized RV305 DH677.3 Fab bound to Clade A/E 93TH057 HIV-1 gp120 core. HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 2.9 X-RAY DIFFRACTION 0.296 0.255 False True IGHV1 IGKV1 Kappa None None None None None 6elu B C 0 A protein serum resistance associated; vsg protein ANTITOXIN 09/29/17 Structure of Serum Resistance Associated protein from T. b. rhodesiense TRYPANOSOMA BRUCEI RHODESIENSE; MUS MUSCULUS mus musculus mus musculus trypanosoma brucei rhodesiense Zoll, S., Higgins, M.K. 2.3 X-RAY DIFFRACTION 0.220 0.191 False True IGHV7 IGKV3 Kappa None None None None None 4hs8 H L 0 A peptide e2-peptide IMMUNE SYSTEM 10/29/12 Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody hu5B3.v3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Eigenbrot, C., Ultsch, M. 2.6 X-RAY DIFFRACTION 0.264 0.222 False True IGHV3 IGKV1 Kappa 1.2000000000000002e-08 -10.805930168369423 Unknown TBD 7z1a F NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.59 X-RAY DIFFRACTION 0.241 0.208 False True IGHV1 NA NA None None None None None 4n1e NA G 0 L protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 4j4p C D 0 B protein ig epsilon chain c region IMMUNE SYSTEM 02/07/13 The complex of human IgE-Fc with two bound Fab fragments HOMO SAPIENS homo sapiens homo sapiens homo sapiens Drinkwater, N., Sutton, B.J. 2.91 X-RAY DIFFRACTION 0.284 0.236 False True IGHV6 IGLV1 Lambda 4e-08 -10.092595930642474 SPR TBD 5t0y I G 0 IMMUNE SYSTEM 08/17/16 2A10 Antibody FAB fragment MUS MUSCULUS mus musculus mus musculus Jackson, C.J., Fisher, C. 3.011 X-RAY DIFFRACTION 0.247 0.225 False True IGHV9 IGKV10 Kappa None None None None None 3b9k H L 0 B protein t-cell surface glycoprotein cd8 beta chain IMMUNE SYSTEM 11/05/07 Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB MUS MUSCULUS; RATTUS RATTUS rattus rattus rattus rattus mus musculus Shore, D., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.284 0.235 False False IGHV2 IGKV19 Kappa None None None None None 4nug H L 0 IMMUNE SYSTEM 12/03/13 Crystal structure of HIV-1 broadly neutralizing antibody PGT151 HOMO SAPIENS homo sapiens homo sapiens Blattner, C., Wilson, I.A. 1.8617 X-RAY DIFFRACTION 0.207 0.159 False True IGHV3 IGKV2D Kappa None None None None None 5ikc B A 0 M protein neuronal migration protein doublecortin TRANSFERASE 03/03/16 X-RAY STRUCURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN in complex with FAB HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Ruf, A., Stihle, M., Benz, J., Thoma, R., Rudolph, M.G. 2.06 X-RAY DIFFRACTION 0.265 0.198 False True IGHV14 IGKV6 Kappa 2.7e-08 -10.325467249642376 SPR TBD 6p60 C D 0 F peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/03/20 Vaccine-elicited NHP FP-targeting neutralizing antibody A12V163-a.02 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.498 X-RAY DIFFRACTION 0.209 0.197 False True IGHV4 IGLV1 Lambda None None None None None 6ysq C NA 0 A protein NA complement c4-b,complement c4-b IMMUNE SYSTEM 04/23/20 The hC4Nb8 complement inhibitory nanobody in complex with C4b ESCHERICHIA COLI; HOMO SAPIENS homo sapiens Zarantonello, A., Laursen, N.S., Andersen, G.R. 3.3 X-RAY DIFFRACTION 0.272 0.221 False True IGHV1 NA NA None None None None None 3qxv E NA 0 E Hapten MTX METHOTREXATE IMMUNE SYSTEM 03/02/11 Structure of an Anti-Methotrexate CDR1-4 Graft VHH Antibody in Complex with Methotrexate LAMA GLAMA lama glama lama glama Fanning, S.W., Horn, J.R. 2.5 X-RAY DIFFRACTION 0.279 0.230 False True IGHV1 4e-09 -11.456840020052727 Unknown TBD 6n16 A B 0 E peptide hiv fusion peptide (512-519) IMMUNE SYSTEM 11/08/18 Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-b.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.302 X-RAY DIFFRACTION 0.274 0.222 False True IGHV4 IGKV2 Kappa None None None None None 4odt H L 0 H carbohydrate GP1 polysaccharide IMMUNE SYSTEM 01/10/14 Fab Structure of lipid A-specific antibody S1-15 in complex with lipid A carbohydrate backbone MUS MUSCULUS mus musculus mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.95 X-RAY DIFFRACTION 0.224 0.197 False False IGHV10 IGKV10 Kappa None None None None None 5wko I J 0 R | O protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 07/25/17 Crystal structure of antibody 27F3 recognizing the HA from A/California/04/2009 (H1N1) influenza virus HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wilson, A., Lang, S., Zhu, X. 3.492 X-RAY DIFFRACTION 0.268 0.246 False True IGHV1 IGKV3 Kappa None None None None None 5tkk H L 0 A peptide hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 10/06/16 Structure of mouse vaccination-elicited HIV neutralizing antibody vFP5.01 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 1.55 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 IGKV6 Kappa 5.2900000000000006e-09 -11.291226680167965 Unknown TBD 4lri P A 0 Immune System 07/19/13 Anti CMV Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Stengel, K.F. 1.65 X-RAY DIFFRACTION 0.212 0.187 False True IGHV3 IGKV2 Kappa None None None None None 1e6o H L 0 IMMUNOGLOBULIN 08/21/00 Crystal structure of Fab13B5 against HIV-1 capsid protein p24 MUS MUSCULUS mus musculus mus musculus Monaco-Malbet, S., Berthet-Colominas, C., Novelli, A., Battai, N., Piga, N., Mallet, F., Cusack, S. 1.8 X-RAY DIFFRACTION 0.255 0.225 False False IGHV1 IGKV4 Kappa None None None None None 6oq8 D NA 0 A protein toxin b TOXIN 04/25/19 Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH 7F CLOSTRIDIOIDES DIFFICILE; CAMELIDAE camelidae clostridioides difficile Chen, P., Lam, K., Jin, R. 2.2 X-RAY DIFFRACTION 0.220 0.197 False True IGHV1 None None None None None 1fsk C B 0 A protein major pollen allergen bet v 1-a IMMUNE SYSTEM 09/11/00 COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 BETULA PENDULA; MUS MUSCULUS mus musculus mus musculus betula pendula Mirza, O., Henriksen, A., Ipsen, H., Larsen, J., Wissenbach, M., Spangfort, M., Gajhede, M. 2.9 X-RAY DIFFRACTION 0.285 0.253 False True IGHV1 IGKV6 Kappa 2.4e-10 -13.12373995487015 Unknown TBD 5cd3 E F 0 IMMUNE SYSTEM 07/02/15 Structure of immature VRC01-class antibody DRVIA7 HOMO SAPIENS homo sapiens homo sapiens Kong, L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.284 0.234 False True unknown IGKV1 Kappa None None None None None 1rur H L 0 immune system 12/11/03 Crystal Structure (I) of native Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set collected at SSRL beamline 9-1. MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 1.5 X-RAY DIFFRACTION unknown unknown False False IGHV1 IGKV2 Kappa None None None None None 7lyv E F 0 NA NA NA NA IMMUNE SYSTEM 03/08/21 Crystal structure of the HCMV pentamer-specific antibody 1-103 HOMO SAPIENS homo sapiens homo sapiens Wrapp, D., Jones, H.G., McLellan, J.S. 1.9 X-RAY DIFFRACTION 0.217 0.191 False True IGHV4 IGKV1 Kappa None None None None None 4xgz Q R 0 q peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 2ajy H L 0 L Hapten ECG 3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER IMMUNE SYSTEM 08/02/05 Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.246 0.225 False False IGHV3 IGKV2 Kappa None None None None None 7mw2 H L 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with all RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5jz7 G I 0 F protein beta-nerve growth factor SIGNALING PROTEIN 05/16/16 NGF IN COMPLEX WITH MEDI578 scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Olsson, L.-L., Aagaard, A. 3.4 X-RAY DIFFRACTION 0.268 0.258 False True IGHV1 IGLV1 Lambda None None None None None 2iff H L 0 Y protein hen egg white lysozyme IMMUNOGLOBULIN/HYDROLASE(O-GLYCOSYL) 02/03/94 STRUCTURE OF AN ANTIBODY-LYSOZYME COMPLEX: EFFECT OF A CONSERVATIVE MUTATION MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Chacko, S., Davies, D.R. 2.65 X-RAY DIFFRACTION unknown unknown False True IGHV1 IGKV4 Kappa 1e-08 -10.913952715282035 Unknown TBD 7r20 B NA 0 NA NA NA NA IMMUNE SYSTEM 02/03/22 Anti-Arc nanobody E5 VICUGNA PACOS vicugna pacos Markusson, S., Kursula, P. 1.42 X-RAY DIFFRACTION 0.237 0.185 False True IGHV1 NA NA None None None None None 7ekk H L 0 P peptide NA mper region of the envelope glycoprotein gp41 from hiv-1 IMMUNE SYSTEM 04/05/21 Anti-HIV-1 broadly neutralizing antibody delta-loop 4E10 modified with pyrene acetamide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caaveiro, J.M.M., Rujas, E., Nieva, J.L. 1.7 X-RAY DIFFRACTION 0.192 0.158 False True IGHV1 IGKV3 Kappa None None None None None 1yym R Q 0 P protein exterior membrane glycoprotein(gp120) Viral protein/Immune system 02/25/05 crystal structure of F23, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.C., Stricher, F., Martin, L., Decker, J.M., Majeed, S., Barthe, P., Hendrickson, W.A., Robinson, J., Roumestand, C., Sodroski, J., Wyatt, R., Shaw, G.M., Vita, C., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.268 0.209 False True IGHV1 IGKV3 Kappa 9.48e-06 -6.852859535761411 SPR TBD 7e5r X S 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5jor H L 0 NA NA NA NA IMMUNE SYSTEM 05/02/16 Crystal structure of unbound anti-glycan antibody Fab14.22 at 2.2 A MUS MUSCULUS mus musculus mus musculus Sarkar, A., Irimia, A., Teyton, L., Wilson, I.A. 2.206 X-RAY DIFFRACTION 0.237 0.205 False True IGHV1 IGKV1 Kappa None None None None None 4fqv I M 0 F | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody CR9114 bound to H7 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Ekiert, D.C., Dreyfus, C., Wilson, I.A. 5.75 X-RAY DIFFRACTION 0.339 0.314 False True IGHV1 IGLV1 Lambda 1.1000000000000001e-09 -12.22172707862036 BLI TBD 7cvs E F 0 B protein NA h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 08/27/20 Crystal structure of the C85A/L194A mutant CLC-ec1 with Fab fragment ESCHERICHIA COLI MS 198-1; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 198-1 Park, K., Mersch, K., Robertson, J., Lim, H.-H. 3.01 X-RAY DIFFRACTION 0.255 0.201 False True IGHV4 IGKV4 Kappa None None None None None 6qfa O NA 0 A protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 01/09/19 CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 HOMO SAPIENS; HELICOBACTER PYLORI (STRAIN G27); LAMA GLAMA helicobacter pylori (strain g27), lama glama homo sapiens Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkoening, A., Zoegg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.49 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3cfj D C 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, orthorhombic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.253 0.199 False True IGHV4 IGLV1 Lambda None None None None None 1hys D C 0 B protein hiv-1 reverse transcriptase TRANSFERASE/DNA-RNA HYBRID 01/22/01 CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Sarafianos, S.G., Das, K., Tantillo, C., Clark Jr., A.D., Ding, J., Whitcomb, J., Boyer, P.L., Hughes, S.H., Arnold, E. 3.0 X-RAY DIFFRACTION 0.316 0.274 False False IGHV8 IGKV10 Kappa None None None None None 6tkc H L 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 ChiLob 7/4 H2 HC-C225S F(ab')2 HOMO SAPIENS Orr, C.M., Fisher, H., Tews, I. 2.3 X-RAY DIFFRACTION 0.236 0.183 False False IGHV1 IGKV10 Kappa None None None None None 6dbd D NA 0 IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R326 LAMA GLAMA lama glama Brooks, C.L., Toride King, M., Huh, I. 1.755 X-RAY DIFFRACTION 0.182 0.160 False True unknown unknown unknown None None None None None 4xmn H L 0 E protein nucleoporin nup120 PROTEIN TRANSPORT 01/14/15 Structure of the yeast coat nucleoporin complex, space group P212121 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE; HOMO SAPIENS, SYNTHETIC CONSTRUCT homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (strain atcc 204508 /s288c) Stuwe, T., Correia, A.R., Lin, D.H., Paduch, M., Lu, V.T., Kossiakoff, A.A., Hoelz, A. 7.6 X-RAY DIFFRACTION 0.347 0.318 False True IGHV3 IGKV1D Kappa None None None None None 1mcj NA B 0 P peptide peptide n-acetyl-d-phe-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 7pbd F NA 0 C | B protein | protein NA | NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 | gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 08/02/21 a1b3 GABA-A receptor + GABA HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Miller, P.S., Kasaragod, V.B. 3.04 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6vmk f e 0 g protein NA unknown HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False False IGHV1 IGKV1 Kappa None None None None None 4nrx D E 0 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66 in complex with gp41 MPER peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Ofek, G., Yang, Y., Kwong, P.D. 2.21 X-RAY DIFFRACTION 0.215 0.188 False True IGHV5 IGKV1 Kappa None None None None None 7x6l I K 0 B | D protein | protein NA | NA hemagglutinin | hemagglutinin STRUCTURAL PROTEIN 03/07/22 Cryo-EM structure of H3 hemagglutinin from A/HongKong/01/1968 in complex with a neutralizing antibody 28-12 HOMO SAPIENS; INFLUENZA A VIRUS (A/HONG KONG/1/1968(H3N2)); INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus (a/hong kong/1/1968(h3n2)) Cong, Y., Liu, C.X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7a29 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/16/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) 2-up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 2.94 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5x08 H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 01/20/17 Crystal structure of broadly neutralizing anti-HIV-1 antibody 4E10, mutant Npro, with peptide bound HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (MAL ISOLATE) homo sapiens homo sapiens human immunodeficiency virus type 1 (malisolate) Caaveiro, J.M.M., Rujas, E., Nieva, J.L., Tsumoto, K. 1.49 X-RAY DIFFRACTION 0.169 0.129 False True IGHV1 IGKV3 Kappa None None None None None 7s6j H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 09/14/21 J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7dk4 c d 0 B protein NA the light chain of 2h2 fab VIRAL PROTEIN 11/23/20 S-2H2-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 2H2 Fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Wang, Y.F. 3.8 ELECTRON MICROSCOPY NA NA False False IGHV2 IGKV3 Kappa None None None None None 6glw C D 0 B protein galectin-10 SUGAR BINDING PROTEIN 05/23/18 Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11 HOMO SAPIENS; LAMA GLAMA lama glama lama glama homo sapiens Verstraete, K., Verschueren, K., Savvides, S.N. 1.9 X-RAY DIFFRACTION 0.211 0.167 False True IGHV3 IGLV2 Lambda None None None None None 6bpa B C 0 A protein reticulocyte binding protein 2, putative CELL INVASION 11/22/17 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 3E9 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus mus musculus plasmodium vivax (strain salvador i) Gruszczyk, J., Chan, L.J., Tham, W.H. 2.53 X-RAY DIFFRACTION 0.225 0.194 False False IGHV14 IGKV17 Kappa None None None None None 7k9h I M 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/20 SARS-CoV-2 Spike in complex with neutralizing Fab 2B04 (one up, two down conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Errico, J.M., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.2 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 6oe5 B C 0 A protein fusion glycoprotein f0,fibritin Viral protein/immune system 03/27/19 Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); ENTEROBACTERIA PHAGE T4; MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 4.1 X-RAY DIFFRACTION 0.306 0.262 False True IGHV2 IGKV1 Kappa None None None None None 7tow A B 0 D peptide NA spike protein s2 IMMUNE SYSTEM/Viral Protein 01/24/22 Antibody DH1058 Fab fragment bound to SARS-CoV-2 fusion peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gobeil, S., Acharya, P. 2.15 X-RAY DIFFRACTION 0.234 0.167 False True IGHV3 IGKV1 Kappa None None None None None 4osu H L 0 IMMUNE SYSTEM 02/13/14 Crystal structure of HCMV gB-neutralizing SM5-1 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Diestel, U., Muller, Y.A. 1.87 X-RAY DIFFRACTION 0.235 0.189 False True IGHV1 IGLV1 Lambda None None None None None 7p77 W NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6x4t D F 0 A protein NA icos ligand IMMUNE SYSTEM 05/23/20 Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain HOMO SAPIENS; ORECTOLOBUS MACULATUS homo sapiens homo sapiens homo sapiens Rujas, E., Sicard, T., Julien, J.P. 3.15 X-RAY DIFFRACTION 0.256 0.201 False True IGHV3 IGKV1 Kappa None None None None None 4wy7 H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 11/16/14 Crystal structure of recombinant 4E10 expressed in Escherichia coli with epitope bound HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 GROUP M SUBTYPE B homo sapiens homo sapiens human immunodeficiency virus type 1 group msubtype b Rujas, E., Morante, K., Tsumoto, K., Nieva, J.L., Caaveiro, J.M.M. 2.1 X-RAY DIFFRACTION 0.207 0.162 False True IGHV1 IGKV3 Kappa 1.67e-07 -9.24586899649438 Unknown TBD 7cws G F 0 R protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 Spike Proteins Trimer in Complex with FC05 and H014 Fabs Cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, L., Wang, X. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4o51 D C 0 O peptide ides hinge peptide IMMUNE SYSTEM 12/19/13 Crystal structure of the QAA variant of anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide ORYCTOLAGUS CUNICULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens homo sapiens Malia, T.J., Luo, J., Teplyakov, A., Gilliland, G.L. 2.204 X-RAY DIFFRACTION 0.213 0.182 False True IGHV1 IGKV1 Kappa None None None None None 6gkd M NA 0 L protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 7akj E D 0 B protein NA spike glycoprotein VIRAL PROTEIN 10/01/20 Structure of the SARS-CoV spike glycoprotein in complex with the 47D11 neutralizing antibody Fab fragment SARS CORONAVIRUS WH20; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus wh20 Fedry, J., Hurdiss, D.L., Wang, C., Li, W., Obal, G., Drulyte, I., Howes, S.C., van Kuppeveld, F.J.M., Foerster, F., Bosch, B.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7jwp I J 0 U peptide NA il-18 peptide IMMUNE SYSTEM 08/26/20 Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payandeh, J., Ho, H. 3.0 X-RAY DIFFRACTION 0.260 0.235 False True IGHV1 IGKV1 Kappa None None None None None 7c4s H L 0 A protein NA sphingosine 1-phosphate receptor 3 MEMBRANE PROTEIN 05/18/20 Sphingosine-1-phosphate receptor 3 with a natural ligand. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Iwata, S., Maeda, S., Luo, F., Nango, E., hirata, K., Asada, H. 3.2 X-RAY DIFFRACTION 0.263 0.242 False False IGHV1 IGKV6 Kappa None None None None None 4cau E e 0 A protein envelope protein e VIRUS 10/09/13 THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB DENGUE VIRUS 1; HOMO SAPIENS homo sapiens dengue virus 1 TEOH, E.P., KUKKARO, P., TEO, E.W., LIM, A.P., TAN, T.T., YIP, A., SCHUL, W., AUNG, M., KOSTYUCHENKO, V.A., LEO, Y.S., CHAN, S.H., SMITH, K.G., CHAN, A.H., ZOU, G., OOI, E.E., KEMENY, D.M., TAN, G.K., NG, J.K., NG, M.L., ALONSO, S., FISHER, D., SHI, P.Y., HANSON, B.J., LOK, S.M., MACARY, P.A. 7.0 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 3jwd H L 0 A protein hiv-1 gp120 envelope glycoprotein VIRAL PROTEIN 09/18/09 Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Majeed, S., Ban, Y.A., Chen, L., Huang, C.C., Kong, L., Kwon, Y.D., Stuckey, J., Zhou, T., Robinson, J.E., Schief, W.R., Sodroski, J., Wyatt, R., Kwong, P.D. 2.61 X-RAY DIFFRACTION 0.275 0.201 False True IGHV1 IGKV1 Kappa None None None None None 4xxd B A 0 C peptide amyloid-beta fragment IMMUNE SYSTEM 01/30/15 Crystal Structure of mid-region amyloid beta capture by solanezumab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Hermans, S.J., Crespi, G.A.N., Parker, M.W., Miles, L.A. 2.41 X-RAY DIFFRACTION 0.290 0.249 False True IGHV3 IGKV2 Kappa None None None None None 3zhd A NA 0 12/21/12 The crystal structure of single domain antibody 8-4 scaffold. HOMO SAPIENS homo sapiens Song, H.-N., Woo, E.-J., Lim, H.-K. 1.962 X-RAY DIFFRACTION 0.2311 0.1779 False True IGHV3 None None None None None 3nif H L 0 A | D protein | protein NA | NA integrin alphaiib beta3 | integrin beta-3 CELL ADHESION/BLOOD CLOTTING 06/15/10 The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Zhu, J.H., Zhu, J.Q., Springer, T.A. 2.4 X-RAY DIFFRACTION 0.216 0.176 False True IGHV14 IGKV14 Kappa None None None None None 5n2k H G 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 4uim E F 0 03/30/15 crystal structure of quinine-dependent Fab 314.3 MUS MUSCULUS mus musculus mus musculus Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.2596 0.2215 False False IGHV1 IGKV10 Kappa None None None None None 7v26 a b 0 A protein NA xg005 heavy chain VIRAL PROTEIN 08/07/21 XG005-bound SARS-CoV-2 S SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Sun, L., Chen, Z.G. 3.85 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 6mnq H L 0 P peptide envelope glycoprotein IMMUNE SYSTEM 10/02/18 Rhesus macaque anti-HIV V3 antibody DH727.2 with gp120 V3 ZAM18 peptide MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Nicely, N.I. 1.804 X-RAY DIFFRACTION 0.225 0.185 False True IGHV1 IGKV2 Kappa None None None None None 4jam A B 0 IMMUNE SYSTEM 02/18/13 Crystal structure of broadly neutralizing anti-hiv-1 antibody ch103 HOMO SAPIENS homo sapiens homo sapiens Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D. 1.65 X-RAY DIFFRACTION 0.197 0.169 False True IGHV4 IGLV3 Lambda None None None None None 1iga B D 0 IMMUNOGLOBULIN 12/23/98 MODEL OF HUMAN IGA1 DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING HOMO SAPIENS homo sapiens homo sapiens Boehm, M.K., Woof, J.M., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 4hs6 H L 0 Y peptide e2-peptide IMMUNE SYSTEM 10/29/12 Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody MRCT10.v362 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Eigenbrot, C., Ultsch, M. 1.53 X-RAY DIFFRACTION 0.200 0.175 False True IGHV4 IGKV1 Kappa 3.0000000000000004e-08 -10.26304286359873 Unknown TBD 5dhy A B 0 C protein protein rev IMMUNE SYSTEM 08/31/15 HIV-1 Rev NTD dimers with variable crossing angles HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C. 3.1 X-RAY DIFFRACTION 0.300 0.291 False True IGHV1 IGKV1 Kappa None None None None None 5xqy NA A 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 3j30 B A 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab CHK152 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 4x4x A B 0 IMMUNE SYSTEM 12/04/14 Retrofitting antibodies with stabilizing mutations. Herceptin scFv mutant. HOMO SAPIENS homo sapiens homo sapiens Langley, D.B., Roome, B., Christ, D. 2.25 X-RAY DIFFRACTION 0.269 0.226 False True IGHV3 IGKV1 Kappa None None None None None 5sv4 A NA 0 TOXIN 08/04/16 Anti-Ricin A-chain Single Domain Antibody A3C8 LAMA GLAMA lama glama Compton, J.R., Legler, P.M. 2.7 X-RAY DIFFRACTION 0.246 0.198 False True IGHV1 None None None None None 6pk8 C c 0 NA NA NA NA IMMUNE SYSTEM 06/28/19 Antibody scFv-M204 dimeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 2.91 X-RAY DIFFRACTION 0.238 0.186 True True unknown unknown unknown None None None None None 7eh3 A NA 6 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6t3j F G 0 J protein NA tumor necrosis factor receptor superfamily member 10b APOPTOSIS 10/11/19 Dual Epitope Targeting by Anti-DR5 Antibodies HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tauchert, M.J., Augustin, M., Krapp, S., Overdijk, M.B., Breij, E.C.W., Hibbert, R.G. 3.05 X-RAY DIFFRACTION 0.282 0.251 False True IGHV14 IGKV3 Kappa None None None None None 2a6d B A 0 P peptide dodecapeptide, rlliadppspre IMMUNE SYSTEM 07/02/05 Crystal structure analysis of the anti-arsonate germline antibody 36-65 in complex with a phage display derived dodecapeptide RLLIADPPSPRE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Sethi, D.K., Agarwal, A., Manivel, V., Rao, K.V., Salunke, D.M. 2.9 X-RAY DIFFRACTION 0.264 0.230 False False IGHV1 IGKV10 Kappa 1.5e-07 -9.309477166508257 Unknown TBD 3zkx B NA 0 A protein beta-secretase 2 HYDROLASE 01/25/13 TERNARY BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kuglstatter, A., Banner, D.W., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski, D., Gsell, B., Hilpert, H., Huber, W., Kusznir, E., Laeremans, T., Matile, H., Rufer, A., Schlatter, D., Steyeart, J., Stihle, M., Thoma, R., Weber, M., Ruf, A. 2.37 X-RAY DIFFRACTION 0.2085 0.1849 False True IGHV3 None None None None None 2ntf B A 0 B Hapten OHM 3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE IMMUNE SYSTEM 11/07/06 Crystal Structure of a Quorum-Quenching Antibody in Complex with an N-Acyl-L-Homoserine Lactone Analog MUS MUSCULUS mus musculus mus musculus mus musculus Debler, E.W., Wilson, I.A. 3.18 X-RAY DIFFRACTION 0.265 0.210 False False IGHV1 IGLV1 Lambda 3.00e-07 -9.25 Other 37 17400249 5ijk A C 0 X peptide peptide pro-leu-gln-pro-glu-gln-pro-phe-pro IMMUNE SYSTEM 03/02/16 Crystal structure of anti-gliadin 1002-1E03 Fab fragment in complex of peptide PLQPEQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens triticum aestivum Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 2.5 X-RAY DIFFRACTION 0.265 0.209 False True IGHV3 IGKV4 Kappa None None None None None 7e5s L D 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7x9e C D 0 F peptide NA spike peptide IMMUNE SYSTEM/VIRAL PROTEIN 03/15/22 Crystal structure of the 76E1 Fab in complex with a SARS-CoV-2 spike peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Chen, X., Zhang, T., Ding, J., Sun, X., Sun, B. 2.6 X-RAY DIFFRACTION 0.243 0.195 False True IGHV3 IGLV2 Lambda None None None None None 5e94 B A 0 G protein glucagon-like peptide 1 receptor MEMBRANE PROTEIN 10/14/15 Antibody-bound Glucagon-like Peptide-1 receptor extracellular domain MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Soroka, V., Schluckebier, G., Reedtz-Runge, S. 2.0 X-RAY DIFFRACTION 0.232 0.188 False True IGHV3 IGKV10 Kappa None None None None None 7kkk D NA 0 C protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/20 SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6fy0 H L 0 P peptide cap45 v2 peptide IMMUNE SYSTEM 03/10/18 Crystal structure of a V2-directed, RV144 vaccine-like antibody from HIV-1 infection, CAP228-16H, bound to a heterologous V2 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Wibmer, C.K., Fernandes, M., Vijayakumar, B., Dirr, H.W., Sayed, Y., Moore, P.L., Morris, L. 2.57 X-RAY DIFFRACTION 0.250 0.210 False True IGHV5 IGLV3 Lambda None None None None None 6ye3 G H 0 I protein NA interleukin-2 PROTEIN BINDING 03/23/20 IL-2 in complex with a Fab fragment from UFKA-20 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Karakus, U., Mittl, P., Boyman, O. 2.89 X-RAY DIFFRACTION 0.283 0.215 False True IGHV5 IGKV8 Kappa None None None None None 4q6i E D 0 J protein t-cell surface glycoprotein cd4 IMMUNE SYSTEM 04/22/14 Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Boyington, J.C., Nabel, G.J., Mascola, J.R. 3.65 X-RAY DIFFRACTION 0.257 0.226 False False IGHV9 IGKV3 Kappa None None None None None 6cnr H L 0 IMMUNE SYSTEM 03/08/18 aducanumab apo Fab HOMO SAPIENS homo sapiens homo sapiens Arndt, J.W. 2.09 X-RAY DIFFRACTION 0.239 0.211 False True IGHV3 IGKV1 Kappa None None None None None 5vl2 A NA 0 A Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 2fgw H L 0 IMMUNOGLOBULIN 01/16/94 X-RAY STRUCTURES OF FRAGMENTS FROM BINDING AND NONBINDING VERSIONS OF A HUMANIZED ANTI-CD18 ANTIBODY: STRUCTURAL INDICATIONS OF THE KEY ROLE OF VH RESIDUES 59 TO 65 HOMO SAPIENS Eigenbrot, C., Kessler, J. 3.0 X-RAY DIFFRACTION unknown 0.176 False True IGHV3 IGKV1 Kappa None None None None None 4w6w B NA 0 A protein f18 fimbrial adhesin ac CELL ADHESION 08/21/14 Co-complex structure of the lectin domain of F18 fimbrial adhesin FedF with inhibitory nanobody NbFedF6 ESCHERICHIA COLI DH5[ALPHA]; LAMA GLAMA lama glama escherichia coli dh5[alpha] Moonens, K., De Kerpel, M., Annelies, C., Cox, E., Pardon, E., Remaut, H., De Greve, H. 2.51 X-RAY DIFFRACTION 0.254 0.197 False True IGHV1 3.57e-09 -11.52422245745632 SPR TBD 4wem B NA 0 A protein k88 fimbrial protein ac STRUCTURAL PROTEIN 09/10/14 Co-complex structure of the F4 fimbrial adhesin FaeG variant ac with llama single domain antibody V1 ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Moonens, K., Van den Broeck, I., Pardon, E., De Kerpel, M., Remaut, H., De Greve, H. 1.55 X-RAY DIFFRACTION 0.193 0.169 False True IGHV1 6.799999999999999e-06 -7.049719172920685 SPR TBD 7n65 K L 0 I protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 06/07/21 Complex structure of HIV superinfection Fab QA013.2 and BG505.SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Mangala Prasad, V., Shipley, M.M., Overbaugh, J.M., Lee, K.K. 4.15 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7web G I 0 D protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein with two XGv347 binding to two open state RBDs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5vzr A B 0 IMMUNE SYSTEM 05/29/17 Crystal Structure of MERS-CoV neutralizing antibody G4 Fab MUS MUSCULUS mus musculus mus musculus Wang, N., Wrapp, D., McLellan, J.S. 1.57 X-RAY DIFFRACTION 0.215 0.182 False True IGHV1 IGKV3 Kappa None None None None None 5vjo C D 0 F protein lysozyme isoform i (del-i) HYDROLASE/IMMUNE SYSTEM 04/19/17 Complex between HyHEL10 Fab fragment heavy chain mutant I29F and Pekin duck egg lysozyme isoform I (DEL-I) MUS MUSCULUS; ANAS PLATYRHYNCHOS mus musculus mus musculus anas platyrhynchos Langley, D.B., Christ, D. 2.43 X-RAY DIFFRACTION 0.296 0.262 False True IGHV3 IGKV5 Kappa None None None None None 4otx I M 0 immune system 02/14/14 Structure of the anti-Francisella tularensis O-antigen antibody N203 Fab fragment MUS MUSCULUS mus musculus mus musculus Lu, Z., Rynkiewicz, M.J., Yang, C.-Y., Madico, G., Perkins, H.M., Roche, M.I., Seaton, B.A., Sharon, J. 2.1 X-RAY DIFFRACTION 0.228 0.193 False False IGHV1 IGKV8 Kappa None None None None None 7wd9 G H 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with three S3H3 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 6bt3 H G 0 K | J protein | protein NA | NA major capsid protein l1 | major capsid protein l1 VIRUS 12/05/17 High-Resolution Structure Analysis of Antibody V5 Conformational Epitope on Human Papillomavirus 16 MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 | human papillomavirus type 16 Guan, J., Bywaters, S.M., Brendle, S.A., Ashley, R.E., Makhov, A.M., Conway, J.F., Christensen, N.D., Hafenstein, S. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 1ehl H L 0 A nucleic-acid 5'-(d(5ht)p*(6-4)t)-3' IMMUNE SYSTEM 02/21/00 64M-2 ANTIBODY FAB COMPLEXED WITH D(5HT)(6-4)T MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Yokoyama, H., Mizutani, R., Satow, Y., Komatsu, Y., Ohtsuka, E., Nikaido, O. 2.4 X-RAY DIFFRACTION 0.279 0.192 False False IGHV1 IGKV1 Kappa None None None None None 7zfd A B 0 F protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-25 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.39 X-RAY DIFFRACTION 0.338 0.286 False True IGHV3 IGKV1 Kappa None None None None None 7kdd F G 0 B protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 10/08/20 HCMV postfusion gB in complex with SM5-1 Fab HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS (STRAIN TOWNE) homo sapiens homo sapiens human cytomegalovirus (strain towne) Liu, Y., Heim, P.K., Che, Y., Chi, X., Qiu, X., Han, S., Dormitzer, P.R., Yang, X. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7lf1 G I 0 A protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7mm0 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 04/29/21 Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, T., Kwong, P.D. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7sht J K 0 D protein NA immunoglobulin heavy constant epsilon IMMUNE SYSTEM 10/11/21 Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Jardetzky, T.S. 7.29 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3chn D N 8 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7swd G g 0 F protein NA virion spike glycoprotein VIRAL PROTEIN/Immune System 11/19/21 Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound ZAIRE EBOLAVIRUS (STRAIN GABON-94); ZAIRE EBOLAVIRUS; HOMO SAPIENS homo sapiens zaire ebolavirus Milligan, J.C., Yu, X., Saphire, E.O. 3.59 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7d3l H L 0 2 protein NA o/tibet/99 vp2 VIRUS 09/19/20 FOOT AND MOUTH DISEASE VIRUS O/TIBET/99-BOUND THE SINGLE CHAIN FRAGMEN ANTIBODY F145 BOS TAURUS; FOOT-AND-MOUTH DISEASE VIRUS bos taurus bos taurus foot-and-mouth disease virus He, Y., Lou, Z. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6psc B b 0 IMMUNE SYSTEM 06/17/20 Antibody scFv-M204 trimeric state ORYCTOLAGUS CUNICULUS oryctolagus cuniculus Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S. 3.6 X-RAY DIFFRACTION 0.282 0.252 True True unknown unknown unknown None None None None None 5ocx H L 0 A peptide cii-c-13-cit IMMUNE SYSTEM 07/04/17 Crystal structure of ACPA E4 in complex with CII-C-13-CIT HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Dobritzsch, D., Ge, C., Holmdahl, R. 1.75 X-RAY DIFFRACTION 0.212 0.176 False True IGHV4 IGLV1 Lambda None None None None None 5d9q I i 0 A protein envelope glycoprotein gp120 IMMUNE SYSTEM 08/18/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Ward, A.B., Wilson, I.A. 4.4 X-RAY DIFFRACTION 0.320 0.290 True True unknown unknown unknown None None None None None 4tvs b NA 0 B protein vhh domain bs-1 MEMBRANE PROTEIN 06/27/14 LAP1(aa356-583), H.sapiens, bound to VHH-BS1 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sosa, B.A., Schwartz, T.U. 1.6 X-RAY DIFFRACTION 0.229 0.181 False False IGHV1 None None None None None 7lab H L 0 C protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/06/21 Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1052 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3u9p K M 0 C protein neutrophil gelatinase-associated lipocalin IMMUNE SYSTEM 10/19/11 Crystal Structure of Murine Siderocalin in Complex with an Fab Fragment MUS MUSCULUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus mus musculus Correnti, C., Strong, R.K. 2.8 X-RAY DIFFRACTION 0.292 0.219 False True IGHV2 IGKV19 Kappa None None None None None 7bnw C NA 0 NA NA NA NA IMMUNE SYSTEM 01/22/21 Llama nanobody nb18 raised against GldL from Flavobacterium jonhsoniae LAMA GLAMA lama glama Trinh, N.T., Cambillau, C., Leone, P. 2.59 X-RAY DIFFRACTION 0.243 0.193 False True IGHV1 NA NA None None None None None 7m30 H L 0 B protein NA envelope glycoprotein l VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25 HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus Wrapp, D., McLellan, J.S. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ws1 I H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6hhu G NA 0 A protein s-layer protein sap STRUCTURAL PROTEIN 08/29/18 Structure of the Bacillus anthracis Sap S-layer assembly domain BACILLUS ANTHRACIS; LAMA GLAMA lama glama bacillus anthracis Remaut, H., Fioravanti, A. 2.7 X-RAY DIFFRACTION 0.250 0.186 False True IGHV1 None None None None None 7phq E NA 0 D protein NA divalent metal cation transporter mnth MEMBRANE PROTEIN 08/18/21 Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA synthetic construct staphylococcus capitis Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 8.45 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7tat F G 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/21 SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (two receptor-binding domains open) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 5w5x H L 0 A protein apoptosis regulator bax APOPTOSIS/IMMUNE SYSTEM 06/16/17 Crystal structure of BAXP168G in complex with an activating antibody HOMO SAPIENS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus homo sapiens Robin, A.Y., Colman, P.M., Czabotar, P.E. 2.502 X-RAY DIFFRACTION 0.244 0.187 False False IGHV1 IGKV22 Kappa None None None None None 4mhj F E 0 C protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 6.98 X-RAY DIFFRACTION 0.387 0.377 False True IGHV1 IGKV3 Kappa 1e-09 -12.27819680469229 BLI TBD 7pry H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with COVOX-45 and beta-6 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 3.1 X-RAY DIFFRACTION 0.291 0.245 False True IGHV4 IGKV3 Kappa None None None None None 6xxn G NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 6zhd E NA 0 C protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 06/22/20 H11-H4 bound to Spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Clare, D.K., Naismith, J.H., Weckener, M., Vogirala, V.K. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3g6d H L 0 A protein interleukin-13 IMMUNE SYSTEM 02/06/09 Crystal structure of the complex between CNTO607 Fab and IL-13 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 3.2 X-RAY DIFFRACTION 0.263 0.213 False True IGHV3 IGLV3 Lambda 1.84e-11 -14.645408833701547 Unknown TBD 7df9 H L 0 A | V protein | peptide NA | NA beta-arrestin-1 | vasopressin v2 receptor phosphopeptide SIGNALING PROTEIN 11/06/20 Crystal of Arrestin2-V2Rpp-1-Fab30 complex BOS TAURUS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus bos taurus | synthetic construct Sun, J.P., Yu, X., Xiao, P., He, Q.T., Lin, J.Y., Zhu, Z.L. 3.17 X-RAY DIFFRACTION 0.281 0.255 False True IGHV3 IGKV1 Kappa None None None None None 7l0l H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral protein 12/11/20 Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer HOMO SAPIENS; INFLUENZA A VIRUS (A/CANADA/720/2005(H2N2)) homo sapiens homo sapiens influenza a virus (a/canada/720/2005(h2n2)) | influenza a virus (a/canada/720/2005(h2n2)) Gorman, J., Kwong, P.D. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7lg6 C D 0 A | I protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/21 BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Torres, J.L., Wu, N.R., Ward, A.B. 3.28 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7mej A NA 0 R protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/06/21 CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb36 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6tej C NA 0 B protein drug abc transporter atp-binding protein MEMBRANE PROTEIN 04/01/20 Structure of apo IrtAB devoid SID in complex with sybody Syb_NL5 MYCOLICIBACTERIUM THERMORESISTIBILE; SYNTHETIC CONSTRUCT synthetic construct mycolicibacterium thermoresistibile Gonda, I., Arnold, F.M., Hutter, C.A.J., Weber, M.S., Seeger, M.A., Hurlimann, L.M. 2.7 X-RAY DIFFRACTION 0.296 0.264 False True IGHV1 None None None None None 7tht d b 0 V protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/12/22 CryoEM structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1042 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., May, A., Acharya, P. 3.42 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 4tvp H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 06/27/14 Structure of BG505 SOSIP.664 in complex with broadly neutralizing antibodies, PGT122 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Zhou, T., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.248 0.214 False True IGHV4 unknown unknown None None None None None 6o23 A B 0 E peptide circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 2243 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.0 X-RAY DIFFRACTION 0.224 0.186 False True IGHV3 IGKV1 Kappa None None None None None 1b2w H L 0 IMMUNE SYSTEM 12/01/98 COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY Fan, Z., Shan, L., Goldsteen, B.Z., Guddat, L.W., Thakur, A., Landolfi, N.F., Co, M.S., Vasquez, M., Queen, C., Ramsland, P.A., Edmundson, A.B. 2.9 X-RAY DIFFRACTION 0.330 0.188 False False IGHV3 IGKV1 Kappa None None None None None 7om4 B NA 0 A protein NA epidermal growth factor receptor IMMUNE SYSTEM 05/21/21 Nanobody EgB4 bound to the full extracellular EGFR-EGF complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Zeronian, M.R., Janssen, B.J.C. 6.05 X-RAY DIFFRACTION 0.327 0.296 False True IGHV1 NA NA None None None None None 6wj1 H L 0 F | E protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 04/11/20 Crystal structure of Fab 54-4H03 bound to H1 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Wilson, I.A. 3.503 X-RAY DIFFRACTION 0.232 0.179 False True IGHV6 IGKV3 Kappa None None None None None 6ghg H L 0 IMMUNE SYSTEM 05/07/18 Variable heavy - variable light domain and Fab-arm CrossMabs with charged residue exchanges HOMO SAPIENS homo sapiens homo sapiens Regula, J., Imhof-Jung, S., Molhoj, M., Benz, J., Ehler, A., Bujotzek, A., Schaefer, W., Klein, C. 1.88 X-RAY DIFFRACTION 0.226 0.195 False True IGHV3 IGKV3 Kappa None None None None None 6iyn A NA 3 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 5ja8 F NA 0 E protein toxin higb-2 TOXIN 04/12/16 Crystal structure of the HigB2 toxin in complex with Nb2 LAMA GLAMA; VIBRIO CHOLERAE SEROTYPE O1 (STRAIN ATCC 39315 / EL TOR INABA N16961) lama glama vibrio cholerae serotype o1 (strain atcc 39315/ el tor inaba n16961) Hadzi, S., Loris, R. 2.49 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 None None None None None 7kqy C NA 0 NA NA NA NA IMMUNE SYSTEM 11/18/20 Crystal Structure and Characterization of Human Heavy-Chain only Antibodies reveals a novel, stable dimeric structure similar to Monoclonal Antibodies HOMO SAPIENS homo sapiens Bahmanjah, S., Mieczkowski, C., Yu, Y., Baker, J., Raghunathan, G., Tomazela, D., Hsieh, M., Mccoy, M., Strickland, C., Fayadat-Dilman, L. 2.913 X-RAY DIFFRACTION 0.260 0.207 False True IGHV1 NA NA None None None None None 7lzp E NA 0 D protein NA botulinum neurotoxin a light chain ANTITOXIN 03/10/21 LC/A-JPU-B9-JPU-A11-JPU-G11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.86 X-RAY DIFFRACTION 0.273 0.235 False True IGHV1 NA NA None None None None None 4ong H L 0 P peptide amyloid beta a4 protein IMMUNE SYSTEM 01/28/14 Fab fragment of 3D6 in complex with amyloid beta 1-40 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Feinberg, H., Saldanha, J.W., Diep, L., Goel, A., Widom, A., Veldman, G.M., Weis, W.I., Schenk, D., Basi, G.S. 2.2 X-RAY DIFFRACTION 0.227 0.177 False True IGHV5 IGKV1 Kappa None None None None None 6o9i D E 0 C protein ecd IMMUNE SYSTEM 03/13/19 Ternary complex of mouse ECD with Fab1 and Fab2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Min, X., Wang, Z. 2.6 X-RAY DIFFRACTION 0.252 0.196 False True IGHV1 IGKV1 Kappa None None None None None 3l95 H L 0 Y protein neurogenic locus notch homolog protein 1 IMMUNE SYSTEM 01/04/10 Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Hymowitz, S.G., de Leon, G.P. 2.19 X-RAY DIFFRACTION 0.271 0.222 False True IGHV3 IGKV1 Kappa 2.50e-09 -11.73 SPR 25 20393564 2rcj M P 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 4ckd I M 0 D protein beta-galactosidase HYDROLASE/IMMUNE SYSTEM 01/03/14 Model of complex between the E.coli enzyme beta-galactosidase and four single chain Fv antibody domains scFv13R4. MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Vinothkumar, K.R., McMullan, G., Henderson, R. 13.0 ELECTRON MICROSCOPY False True IGHV3 IGKV5 Kappa None None None None None 3vw3 H L 0 A | B | A nucleic-acid | nucleic-acid | nucleic-acid 64T | NA | NA 5-HYDROXY-THYMIDINE-5'-MONOPHOSPHATE | dna (5'-d(*cp*cp*cp*gp*tp*cp*cp*ap*tp*ap*ap*tp*cp*ap*cp*tp*cp*g)-3') | dna (5'-d(*gp*cp*gp*ap*gp*tp*gp*ap*(64t)p*(5py)p*ap*tp*gp*gp*ap*cp*gp*g)-3') IMMUNE SYSTEM/DNA 07/30/12 Antibody 64M-5 Fab in complex with a double-stranded DNA (6-4) photoproduct MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | | Yokoyama, H., Mizutani, R., Satow, Y. 2.5 X-RAY DIFFRACTION 0.290 0.247 False False IGHV1 IGKV1 Kappa 2.1999999999999998e-07 -9.082560507480071 Unknown TBD 7k8v H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C110 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Dam, K.A., Barnes, C.O., Bjorkman, P.J. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 6c6x C D 0 IMMUNE SYSTEM 01/19/18 Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque. MACACA MULATTA macaca mulatta macaca mulatta Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.208 0.176 False True IGHV4 IGKV1 Kappa None None None None None 6fys D NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 7lkb H L 0 A peptide NA circumsporozoite protein IMMUNE SYSTEM/ANTIGEN 02/02/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.127 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum 3d7 Xu, K., Kwong, P.D. 1.8 X-RAY DIFFRACTION 0.217 0.181 False True IGHV1 IGKV4 Kappa None None None None None 7kex I L 0 C protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-293 HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5ocl B NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA lama glama Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 6mhr D E 0 F protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 09/18/18 Structure of the human 4-1BB / Urelumab Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kimberlin, C.R., Chin, S.M., Roe-Zurz, Z., Xu, A., Yang, Y. 2.8 X-RAY DIFFRACTION 0.222 0.200 False True IGHV4 IGKV3 Kappa 2.2000000000000002e-08 -10.446804596890326 SPR TBD 7t0k D C 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-2 Fab Unliganded 4 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.0 X-RAY DIFFRACTION 0.255 0.222 False True IGHV7 IGKV8 Kappa None None None None None 4fqr o p 0 O protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 7d85 B C 0 A protein NA receptor tyrosine-protein kinase erbb-3 IMMUNE SYSTEM 10/07/20 Crystal structure of anti-ErbB3 Fab ISU104 in complex with human ErbB3 extracellular domain 3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yoo, Y., Cho, H.S. 2.5 X-RAY DIFFRACTION 0.258 0.203 False True IGHV3 IGLV1 Lambda None None None None None 7lj5 E D 0 A protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel FHIEG mutant A198E in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.26 X-RAY DIFFRACTION 0.252 0.220 False True IGHV1 IGKV4 Kappa None None None None None 5uk4 t NA 0 T protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 4f58 H L 0 IMMUNE SYSTEM 05/12/12 Fab structure of a neutralizing antibody L3 from an early subtype A HIV-1 infected patient HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.488 X-RAY DIFFRACTION 0.256 0.208 False False IGHV3 IGLV2 Lambda None None None None None 4ej1 C NA 0 B protein dihydrofolate reductase Oxidoreductase/Immune system 04/06/12 Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Oyen, D., Srinivasan, V. 1.75 X-RAY DIFFRACTION 0.224 0.186 False True IGHV1 None None None None None 4at6 A B 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 7ws7 G F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7lf0 K L 0 N protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1w72 H L 0 A | C protein | peptide NA | NA hla class i histocompatibility antigen | melanoma-associated antigen 1 IMMUNE SYSTEM 08/27/04 Crystal structure of HLA-A1:MAGE-A1 in complex with Fab-Hyb3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | homo sapiens Hulsmeyer, M., Chames, P., Hillig, R.C., Stanfield, R.L., Held, G., Coulie, P.G., Alings, C., Wille, G., Saenger, W., Ziegler, B.Uchanska-, Hoogenboom, H.R., Zieger, A. 2.15 X-RAY DIFFRACTION 0.248 0.182 False True IGHV3 IGLV3 Lambda 1.40e-08 -10.71 SPR 15537658 7lf0 G I 0 A protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7mjl H L 0 A protein NA spike glycoprotein Viral Protein/Immune System 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (focused refinement of RBD and Fab ab1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.95 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7ezh H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/01/21 Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Liu, Q.F., Yang, D.H., Zhuang, Y.W., Croll, T.I., Cai, X.Q., Duan, J., Dai, A.T., Yin, W.C., Ye, C.Y., Zhou, F.L., Wu, B.L., Zhao, Q., Xu, H.E., Wang, M.W., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2kh2 B b 60 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 1oar H L 0 IMMUNE SYSTEM 01/21/03 Fv IgE SPE-7 in complex with Alizarin Red RATTUS RATTUS rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.23 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 IGLV1 Lambda 4.00e-08 Other 20 12610298 7l6v B NA 0 A protein NA bont/a ANTITOXIN 12/24/20 Crystal structure of BoNT/A-LC-JPU-A5-JPU-C1-JPU-H7-JPU-D12-ciA-F12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.01 X-RAY DIFFRACTION 0.234 0.197 False True IGHV1 NA NA None None None None None 4grw G NA 0 B protein interleukin-12 subunit beta IMMUNE SYSTEM 08/27/12 Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) LLAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C. 2.55 X-RAY DIFFRACTION 0.218 0.183 False True IGHV1 None None None None None 1c5c H L 0 L Hapten TK4 2-ACETYLAMINO-NAPTHALENE-1,5-DISULFONIC ACID IMMUNE SYSTEM 11/09/99 DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Hotta, K., Wilson, I.A. 1.61 X-RAY DIFFRACTION unknown unknown False True IGHV1 IGKV9 Kappa 1.1e-07 -9.493238899799852 Unknown TBD 2kqn NA A 16 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6rbb H NA 0 IMMUNE SYSTEM 05/13/20 CRYSTAL STRUCTURE OF the VhH-domain of anti-IL-17A antibody netakimab LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 2.45 X-RAY DIFFRACTION 0.280 0.216 False True IGHV1 None None None None None 4b5e A NA 0 IMMUNE SYSTEM 08/03/12 Crystal Structure of an amyloid-beta binding single chain antibody PS2-8 LAMA GLAMA lama glama Beringer, D.X., Dorresteijn, B., Rutten, L., Wienk, H., el Khattabi, M., Kroon-Batenburg, L.M.J., Verrips, C.T. 1.936 X-RAY DIFFRACTION 0.2356 0.1812 False True IGHV1 None None None None None 7rxc N NA 0 K protein NA er lumen protein-retaining receptor 2 STRUCTURAL PROTEIN 08/22/21 CryoEM structure of KDELR with Legobody MUS MUSCULUS; VICUGNA PACOS; ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS SP.; GALLUS GALLUS vicugna pacos gallus gallus Wu, X.D., Rapoport, T.A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1sjx A NA 0 IMMUNE SYSTEM 03/04/04 Three-Dimensional Structure of a Llama VHH Domain OE7 binding the cell wall protein Malf1 LAMA GLAMA lama glama Dolk, E., van der Vaart, M., Hulsik, D.L., Vriend, G., de Haard, H., Spinelli, S., Cambillau, C., Frenken, L., Verrips, T. 2.2 X-RAY DIFFRACTION 0.206 0.191 False True IGHV1 None None None None None 4w2p A NA 0 IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C LAMA GLAMA lama glama Taylor, A.B., Garza, J.A. 1.77 X-RAY DIFFRACTION 0.203 0.165 False True IGHV1 None None None None None 6rtw B NA 0 A protein protein patched homolog 1 MEMBRANE PROTEIN 05/27/19 Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Rudolf, A.F., Kowatsch, C., El Omari, K., Malinauskas, T., Kinnebrew, M., Ansell, T.B., Bishop, B., Pardon, E., Schwab, R.A., Qian, M., Duman, R., Covey, D.F., Steyaert, J., Wagner, A., Sansom, M.S.P., Rohatgi, R., Siebold, C. 1.9 X-RAY DIFFRACTION 0.230 0.185 False True IGHV1 None None None None None 5wcc H L 0 IMMUNE SYSTEM 06/29/17 Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 02-1F07 Fab. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Andrews, S.F., Mascola, J.R., McDermott, A.B., Kwong, P.D. 2.461 X-RAY DIFFRACTION 0.240 0.203 False True IGHV3 IGLV2 Lambda None None None None None 6ru3 C NA 0 IMMUNE SYSTEM 05/27/19 Crystal structure of the FP specific nanobody hFPNb1 LAMA GLAMA lama glama Mazarakis, S.M.M., Pedersen, D.V., Laursen, N.S., Andersen, G.R. 1.26 X-RAY DIFFRACTION 0.204 0.188 False True IGHV1 None None None None None 5kel J N 0 E protein ebola surface glycoprotein, gp1 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 ZAIRE EBOLAVIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) homo sapiens homo sapiens zaire ebolavirus (strain mayinga-76) Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV8 IGKV6 Kappa None None None None None 6dwi L K 0 L carbohydrate HD4 4-O-[2-acetamido-2-deoxy-beta-D-glucopyranosyl]-1-O-phosphono-D-ribitol IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 6um7 F G 0 E protein envelope glycoprotein gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of vaccine-elicited HIV-1 neutralizing antibody DH270.mu1 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunders, K., Haynes, B.F. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7m71 H L 0 A | B protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 03/26/21 SARS-CoV-2 Spike:5A6 Fab complex I focused refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Asarnow, D., Cheng, Y. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6wn1 B C 0 A protein NA reticulocyte binding protein 2b CELL INVASION 04/22/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 241242 PLASMODIUM VIVAX SAL-1; HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax sal-1 Chan, L.J., Dietrich, M.H., Tham, W.H. 3.15 X-RAY DIFFRACTION 0.283 0.251 False True IGHV3 IGLV3 Lambda None None None None None 3wfb H L 0 B | C protein | protein NA | NA nitric oxide reductase subunit b | nitric oxide reductase subunit c IMMUNE SYSTEM/OXIDOREDUCTASE 07/18/13 Reduced cytochrome c-dependent nitric oxide reductase (cNOR) from Pseudomonas aeruginosa in complex with antibody fragment PSEUDOMONAS AERUGINOSA; MUS MUSCULUS mus musculus mus musculus pseudomonas aeruginosa | pseudomonas aeruginosa Sato, N., Ishii, S., Hino, T., Sugimoto, H., Fukumori, Y., Shiro, Y., Tosha, T. 2.7 X-RAY DIFFRACTION 0.250 0.202 False False IGHV1 IGKV16 Kappa None None None None None 4tuj A B 0 E peptide peptide1 IMMUNE SYSTEM 06/24/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Grudnik, P., Golik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G. 1.89 X-RAY DIFFRACTION 0.232 0.179 False True IGHV1 IGKV1 Kappa None None None None None 3b2v H L 0 A protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 3.3 X-RAY DIFFRACTION 0.367 0.282 False True IGHV4 IGKV3 Kappa 3.30e-09 -11.56 SPR 25 18275813 5lqb H L 0 A protein interleukin-2 CYTOKINE 08/16/16 Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zou, C., Wirth, E. 1.95 X-RAY DIFFRACTION 0.291 0.189 False False IGHV1 IGKV3 Kappa None None None None None 4dgy H L 0 A peptide e2 peptide IMMUNE SYSTEM/VIRAL PROTEIN 01/27/12 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody HCV1, C2 form HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Kong, L., Wilson, I.A., Law, M. 1.798 X-RAY DIFFRACTION 0.221 0.188 False True IGHV3 IGKV3 Kappa None None None None None 1jnl H L 0 IMMUNE SYSTEM 07/24/01 Crystal Structure of Fab-Estradiol Complexes MUS MUSCULUS mus musculus mus musculus Monnet, C., Bettsworth, F., Stura, E.A., Le Du, M.-H., Menez, R., Derrien, L., Zinn-Justin, S., Gilquin, B., Sibai, G., Battail-Poirot, N., Jolivet, M., Menez, A., Arnaud, M., Ducancel, F., Charbonnier, J.B. 3.0 X-RAY DIFFRACTION 0.290 0.195 False False IGHV14 IGKV12 Kappa None None None None None 6njl L l 0 A protein glutamate receptor 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.7 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 7k8x D F 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Abernathy, M.E., Barnes, C.O., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 7qny A B 0 E protein NA surface glycoprotein VIRAL PROTEIN 12/23/21 The receptor binding domain of SARS-CoV-2 spike glycoprotein in complex with COVOX-58 and COVOX-158 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.84 X-RAY DIFFRACTION 0.278 0.226 False True IGHV3 IGLV3 Lambda None None None None None 7s6l H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 09/14/21 J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (conformation 3) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5fcs L l 0 IMMUNE SYSTEM 12/15/15 Diabody HOMO SAPIENS homo sapiens Mosyak, L., Root, A. 2.01 X-RAY DIFFRACTION 0.205 0.176 True True unknown unknown unknown None None None None None 6oel H L 0 B | C protein | protein NA | NA interleukin-4 receptor subunit alpha | cytokine receptor common subunit gamma IMMUNE SYSTEM 03/27/19 Engineered Fab bound to IL-4 receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Jude, K.M., Moraga, I., Spangler, J.B., Garcia, K.C. 3.1 X-RAY DIFFRACTION 0.256 0.199 False True IGHV6 IGKV1 Kappa None None None None None 2exy C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 11/09/05 Crystal structure of the E148Q Mutant of EcClC, Fab complexed in absence of bound ions ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lobet, S., Dutzler, R. 3.1 X-RAY DIFFRACTION 0.352 0.328 False False IGHV4 IGKV4 Kappa None None None None None 5gs2 H h 0 A protein maltose-binding periplasmic protein SUGAR BINDING PROTEIN/IMMUNE SYSTEM 08/13/16 Crystal structure of diabody complex with repebody and MBP MUS MUSCULUS; HOMO SAPIENS; ESCHERICHIA COLI (STRAIN K12); ESCHERICHIA COLI homo sapiens escherichia coli (strain k12) Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 3.592 X-RAY DIFFRACTION 0.278 0.217 True True unknown unknown unknown None None None None None 6nmu H L 0 S protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 01/11/19 Kick-Off Fab 115 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wibowo, A.S., Carter, J.J., Sim, J. 2.55 X-RAY DIFFRACTION 0.261 0.193 False True IGHV3 IGKV3 Kappa None None None None None 3v6z C D 0 E protein e-antigen IMMUNE SYSTEM 12/20/11 Crystal Structure of Hepatitis B Virus e-antigen HEPATITIS B VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis b virus Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. 3.34 X-RAY DIFFRACTION 0.233 0.234 False False IGHV5 IGKV8 Kappa 3.3e-09 -11.570817226937057 SPR TBD 7ahu H L 0 C | D protein | protein NA | NA coagulation factor x | coagulation factor x BLOOD CLOTTING 09/25/20 Anti-FX Fab of mim8 in complex with human FXa HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Johansson, E. 2.6 X-RAY DIFFRACTION 0.263 0.203 False True IGHV5 IGKV3 Kappa None None None None None 6x87 G H 0 X protein NA circumsporozoite protein IMMUNE SYSTEM 06/01/20 CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Kucharska, I., Thai, E., Rubinstein, J., Julien, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7ejk H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/02/21 Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Xu, J., Cao, S., Liu, Z., Du, Y. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4yhz H L 0 P peptide h3k4me3 peptide IMMUNE SYSTEM 02/27/15 Crystal structure of 304M3-B Fab in complex with H3K4me3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Hattori, T., Dementieva, I.S., Montano, S.P., Koide, S. 2.304 X-RAY DIFFRACTION 0.213 0.183 False True IGHV3 IGLV3 Lambda 1.1000000000000001e-08 -10.857482989210107 Unknown TBD 5o0w E NA 0 A protein fructose-bisphosphate aldolase LYASE 05/17/17 Crystal structure of the complex between Nb474 and Trypanosoma congolense fructose-1,6-bisphosphate aldolase TRYPANOSOMA CONGOLENSE (STRAIN IL3000); VICUGNA PACOS vicugna pacos trypanosoma congolense (strain il3000) Pinto, J., Magez, S., Sterckx, Y. 2.57 X-RAY DIFFRACTION 0.222 0.192 False True IGHV1 7.382999999999999e-11 -13.822203424535738 SPR TBD 5b4m C D 0 IMMUNE SYSTEM 04/05/16 Crystal structure of an Fab against human influenza A MUS MUSCULUS mus musculus mus musculus Yuan, Y.A. 2.4 X-RAY DIFFRACTION 0.338 0.285 False False IGHV5 IGKV3 Kappa None None None None None 6xpq B C 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/08/20 Human antibody D1 H1-17/H3-14 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2) INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 4.2 X-RAY DIFFRACTION 0.307 0.273 False True IGHV4 IGKV1 Kappa None None None None None 3wii I M 0 IMMUNE SYSTEM 09/12/13 Crystal structure of the Fab fragment of B2212A, a murine monoclonal antibody specific for the third fibronectin domain (Fn3) of human ROBO1. MUS MUSCULUS mus musculus mus musculus Nakayama, T., Mizohata, E., Yamashita, T., Nagatoishi, S., Nakakido, M., Iwanari, H., Mochizuki, Y., Kado, Y., Yokota, Y., Sato, R., Tsumoto, K., Fujitani, H., Kodama, T., Hamakubo, T., Inoue, T. 1.6 X-RAY DIFFRACTION 0.230 0.185 False False IGHV1 IGKV10 Kappa None None None None None 6xuk H L 0 A carbohydrate NAG N-ACETYL-D-GLUCOSAMINE ANTITUMOR PROTEIN 01/20/20 AbLIFT design 15 of Ab 1116NS19.9 MUS MUSCULUS mus musculus mus musculus Diskin, R., Borenstein-Katz, A. 1.42 X-RAY DIFFRACTION 0.185 0.149 False True IGHV6 IGKV14 Kappa None None None None None 3v6f A B 0 IMMUNE SYSTEM 12/19/11 Crystal Structure of an anti-HBV e-antigen monoclonal Fab fragment (e6), unbound MUS MUSCULUS mus musculus mus musculus Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. 2.52 X-RAY DIFFRACTION 0.220 0.179 False False IGHV5 IGKV8 Kappa None None None None None 7f07 C NA 0 NA NA NA NA RNA BINDING PROTEIN 06/03/21 Autonomous VH domain that interacts with eIF4E at the Capped mRNA Binding site. HOMO SAPIENS; MUS MUSCULUS mus musculus Brown, C.J., Frosi, Y., Ng, S., Lin, Y.C. 2.25 X-RAY DIFFRACTION 0.266 0.215 False True IGHV3 NA NA None None None None None 6cyf U T 0 Q protein type iii secretion system protein IMMUNE SYSTEM 04/05/18 PcrV fragment with bound Fab PSEUDOMONAS AERUGINOSA; HOMO SAPIENS homo sapiens homo sapiens pseudomonas aeruginosa Oganesyan, V. 2.78 X-RAY DIFFRACTION 0.249 0.215 False True IGHV3 IGKV1 Kappa None None None None None 3gjf M K 0 D | F protein | peptide NA | NA hla class i histocompatibility antigen, a-2alpha chain | nyeso-1 peptide IMMUNE SYSTEM 03/08/09 Rational development of high-affinity T-cell receptor-like antibodies HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens | Stewart-Jones, G., Wadle, A., Hombach, A., Shenderov, E., Held, G., Fischer, E., Kleber, S., Stenner-Liewen, F., Bauer, S., McMichael, A., Knuth, A., Abken, H., Hombach, A.A., Cerundolo, V., Jones, E.Y., Renner, C. 1.9 X-RAY DIFFRACTION 0.251 0.202 False True IGHV3 IGLV2 Lambda 6.30e-08 -9.82 SPR 19307587 6qd6 J NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 7ns6 G NA 0 L protein NA spike glycoprotein,fibritin VIRAL PROTEIN 03/05/21 SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies VICUGNA PACOS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4 vicugna pacos severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Das, H., Hallberg, B.M. 3.18 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2kh2 B b 53 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7r8n O P 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C051 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 5vm4 B NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 6rco C D 0 IMMUNE SYSTEM 04/11/19 PfRH5-binding monoclonal antibody R5.004 HOMO SAPIENS homo sapiens homo sapiens Alanine, D.G.W., Draper, S.J., Higgins, M.K. 1.66 X-RAY DIFFRACTION 0.204 0.183 False True IGHV1 IGLV1 Lambda None None None None None 2kqm NA B 14 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 4laj I NA 0 B | C protein | peptide NA | NA hiv-1 yu2 gp120 envelope glycoprotein | cd4-mimetic miniprotein m48u1 VIRAL PROTEIN/INHIBITOR 06/20/13 Crystal structure of HIV-1 YU2 envelope gp120 glycoprotein in complex with CD4-mimetic miniprotein, M48U1, and llama single-domain, broadly neutralizing, co-receptor binding site antibody, JM4 HUMAN IMMUNODEFICIENCY VIRUS 1; LLAMA GLAMA; SYNTHETIC CONSTRUCT lama glama human immunodeficiency virus 1 | Acharya, P., Luongo, T.S., Kwong, P.D. 2.14 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 None None None None None 5ezl H L 0 IMMUNE SYSTEM 11/26/15 Crystal Structure of Fab c12 MUS MUSCULUS mus musculus mus musculus Favuzza, P., Pluschke, G., Rudolph, M.G. 2.43 X-RAY DIFFRACTION 0.245 0.187 False True IGHV4 IGKV6 Kappa None None None None None 5f1o B NA 0 A protein adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 HYDROLASE/IMMUNE SYSTEM 11/30/15 human CD38 in complex with nanobody MU551 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Zhang, H., Hao, Q. 2.2 X-RAY DIFFRACTION 0.237 0.168 False True IGHV1 None None None None None 3k81 A NA 0 D protein mp18 rna editing complex protein Immune System, RNA Binding Protein 10/13/09 Structure of the central interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies TRYPANOSOMA BRUCEI; LAMA GLAMA lama glama trypanosoma brucei Park, Y.-J., Hol, W. 3.4 X-RAY DIFFRACTION 0.320 0.267 False True IGHV1 None None None None None 2kh2 B b 10 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 3w9d C D 0 IMMUNE SYSTEM 04/03/13 Structure of Human Monoclonal Antibody E317 Fab HOMO SAPIENS homo sapiens homo sapiens Lee, C.C., Lin, L.L., Wang, A.H.J. 2.32 X-RAY DIFFRACTION 0.259 0.190 False True IGHV1 IGKV3 Kappa None None None None None 7ew2 S s 0 A | C | B protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/24/21 Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein HOMO SAPIENS homo sapiens homo sapiens | homo sapiens | homo sapiens Zhao, C., Wang, W., Wang, H.L., Shao, Z.H. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3chn D N 0 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 4cad B A 0 C protein ras and a-factor converting enzyme 1, rce1 PROTEIN BINDING 10/08/13 Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 METHANOCOCCUS MARIPALUDIS; MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis Kulkarni, K., Manolaridis, I., Dodd, R.B., Cronin, N., Ogasawara, S., Iwata, S., Barford, D. 2.5 X-RAY DIFFRACTION 0.2669 0.2262 False False IGHV1 IGKV12 Kappa None None None None None 4lf3 B A 0 C protein glucagon receptor IMMUNE SYSTEM 06/26/13 Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Murray, J.M., Mukund, S. 2.735 X-RAY DIFFRACTION 0.264 0.209 False True IGHV3 IGKV1 Kappa None None None None None 4krp D C 0 A protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR HOMO SAPIENS; LAMA GLAMA; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Ferguson, K.M., Schmitz, K.R. 2.823 X-RAY DIFFRACTION 0.263 0.215 False True IGHV2 IGKV5 Kappa 1.66e-07 -9.249427467731744 SPR TBD 7kx4 D A 0 NA NA NA NA IMMUNE SYSTEM 12/03/20 Anti-CCHFV ADI-36121 Fab HOMO SAPIENS homo sapiens homo sapiens Mishra, A.K., McLellan, J.S. 2.6 X-RAY DIFFRACTION 0.239 0.198 False True IGHV3 IGKV1 Kappa None None None None None 6vkn G J 0 C | F protein | protein NA | NA envelope glycoprotein gp160 | bg505 sosipv5.2 gp41 VIRAL PROTEIN/Immune System 01/21/20 BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4ocl C NA 0 B | A protein | protein NA | NA 26s proteasome regulatory subunit rpn11 | 26s proteasome regulatory subunit rpn8 HYDROLASE, PROTEIN BINDING 01/09/14 Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form Ia SACCHAROMYCES CEREVISIAE; LAMA GLAMA lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Pathare, G.R., Bracher, A. 2.4 X-RAY DIFFRACTION 0.252 0.195 False True IGHV1 NA NA None None None None None 6ss6 J N 0 C protein NA unknown PROTEIN BINDING 09/06/19 Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 3.25 X-RAY DIFFRACTION 0.361 0.300 False False IGHV3 IGLV1 Lambda None None None None None 6x1a N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/18/20 Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Belousoff, M.J., Zhang, X., Danev, R. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1mco H L 0 IMMUNOGLOBULIN 02/25/93 THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION HOMO SAPIENS homo sapiens homo sapiens Guddat, L.W., Edmundson, A.B. 3.2 X-RAY DIFFRACTION unknown 0.232 False False IGHV4 IGLV2 Lambda None None None None None 6ad7 E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148D mutant CLC-ec1 in 20 mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 2.95 X-RAY DIFFRACTION 0.269 0.223 False False IGHV4 IGKV4 Kappa None None None None None 5l6q NA A 0 IMMUNE SYSTEM 05/31/16 Refolded AL protein from cardiac amyloidosis HOMO SAPIENS homo sapiens Annamalai, K., Liberta, F., Vielberg, M.-T., Lilie, H., Guehrs, K.-H., Schierhorn, A., Koehler, R., Schmidt, A., Haupt, C., Hegenbart, O., Schoenland, S., Groll, M., Faendrich, M. 1.4 X-RAY DIFFRACTION 0.182 0.147 False False IGLV3 Lambda None None None None None 7ly2 M K 0 J protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2M28 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5w08 G H 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 05/30/17 A/Texas/50/2012(H3N2) Influenza hemagglutinin in complex with K03.12 Fab INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 2.6 X-RAY DIFFRACTION 0.262 0.240 False True IGHV1 IGLV2 Lambda 4e-08 -10.092595930642474 SPR TBD 4n1e NA H 0 L protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 4r4b D C 0 NA NA NA NA IMMUNE SYSTEM 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Acharya, P., Huang, C.-C., Robinson, J., Kwong, P.D. 2.199 X-RAY DIFFRACTION 0.214 0.166 False True IGHV4 IGKV1 Kappa None None None None None 6n4y G NA 0 D protein metabotropic glutamate receptor 5 MEMBRANE PROTEIN 11/20/18 Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K. 3.262 X-RAY DIFFRACTION 0.251 0.199 False True IGHV1 None None None None None 7uem D C 0 B carbohydrate GAL BETA-D-GALACTOSE IMMUNE SYSTEM 03/22/22 Genomic and structural basis for the human anti-alpha-galactosyl antibody response Homo sapiens homo sapiens homo sapiens Langley, D.B., Christ, D. 2.314 X-RAY DIFFRACTION 0.231 0.189 False True IGHV3 IGKV2 Kappa None None None None None 2x1p C NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama VandenAbbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., VanLoo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.1 X-RAY DIFFRACTION 0.220 0.203 False True IGHV1 None None None None None 2hrp H L 0 P peptide hiv-1 protease peptide COMPLEX (IMMUNOGLOBULIN/PEPTIDE) 12/27/96 ANTIGEN-ANTIBODY COMPLEX MUS MUSCULUS mus musculus mus musculus Lescar, J., Bentley, G.A. 2.2 X-RAY DIFFRACTION 0.289 0.198 False False IGHV5 IGKV3 Kappa 5.00e-09 -11.32 SPR 9150407 2xxc B NA 0 IMMUNE SYSTEM 11/10/10 Crystal structure of a camelid VHH raised against the HIV-1 capsid protein C-terminal domain. VICUGNA PACOS vicugna pacos Igonet, S., Vaney, M.-C., Bartonova, V., Helma, J., Rothbauer, U., Leonhardt, H., Stura, E., Krausslich, H.-G., Rey, F.A. 1.67 X-RAY DIFFRACTION 0.2101 0.1800 False True IGHV1 None None None None None 4nwu H L 0 IMMUNE SYSTEM 12/06/13 Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in CDR H1 HOMO SAPIENS homo sapiens homo sapiens Verdino, P., Stanfield, R.L., Wilson, I.A. 1.602 X-RAY DIFFRACTION 0.198 0.166 False True IGHV1 IGKV4 Kappa None None None None None 2qtj D N 1 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6oc8 D NA 0 IMMUNE SYSTEM 03/22/19 Crystal structure of a VHH against the capsid protein from BLV LAMA GLAMA lama glama Carrion, F., Larrieux, N., Trajtenberg, F., Buschiazzo, A. 2.109 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 None None None None None 2cd0 NA A 0 IMMUNE SYSTEM 03/08/99 STRUCTURE OF HUMAN LAMBDA-6 LIGHT CHAIN DIMER WIL HOMO SAPIENS homo sapiens Pokkuluri, P.R., Solomon, A., Weiss, D.T., Stevens, F.J., Schiffer, M. 1.8 X-RAY DIFFRACTION 0.351 0.289 False True IGLV6 Lambda None None None None None 3tt1 H L 0 B protein leucine transporter leut TRANSPORT PROTEIN 09/13/11 Crystal Structure of LeuT in the outward-open conformation in complex with Fab AQUIFEX AEOLICUS; MUS MUSCULUS mus musculus mus musculus aquifex aeolicus Krishnamurthy, H., Gouaux, E. 3.099 X-RAY DIFFRACTION 0.240 0.219 False True IGHV1 IGKV3 Kappa None None None None None 5hm1 B NA 0 E peptide gp41 IMMUNE SYSTEM 01/15/16 Llama VHH 2E7 in complex with gp41 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama hiv-1 m Hock, M., Caillat, C., Haffke, M., Weissenhorn, W. 2.962 X-RAY DIFFRACTION 0.249 0.194 False True IGHV1 None None None None None 4m6m H L 0 IMMUNE SYSTEM 08/09/13 Crystal structure of anti-IL-23 antibody CNTO1959 at pH 9.5 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.221 0.184 False True IGHV5 IGLV1 Lambda None None None None None 1kno B A 0 B Hapten PNP METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER CATALYTIC ANTIBODY 09/11/95 CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES MUS MUSCULUS mus musculus mus musculus mus musculus Charbonnier, J.-B., Gigant, B., Knossow, M. 3.2 X-RAY DIFFRACTION 0.272 0.200 False False IGHV5 IGKV9 Kappa None None None None None 1igj B A 0 B Hapten DGX DIGOXIN IMMUNOGLOBULIN 02/19/93 26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY MUS MUSCULUS mus musculus mus musculus mus musculus Jeffrey, P.D., Sheriff, S. 2.5 X-RAY DIFFRACTION unknown 0.176 False True IGHV1 IGKV1 Kappa 4.17e-11 -13.91 Other 20 8234291 1efq NA A 0 IMMUNE SYSTEM 02/09/00 Q38D mutant of LEN HOMO SAPIENS homo sapiens Pokkuluri, P.R., Cai, X., Gu, M., Stevens, F.J., Schiffer, M. 1.6 X-RAY DIFFRACTION 0.288 0.230 False True IGKV4 Kappa None None None None None 7t0i H L 0 NA NA NA NA IMMUNE SYSTEM 11/29/21 Crystal structure of S25-39 Fab Unliganded 3 MUS MUSCULUS mus musculus mus musculus Legg, M.S.G., Blackler, R.J., Evans, S.V. 2.1 X-RAY DIFFRACTION 0.225 0.180 False True IGHV7 IGKV8 Kappa None None None None None 3v4p M N 0 D | C protein | protein NA | NA integrin beta-7 | integrin alpha-4 CELL ADHESION 12/15/11 crystal structure of a4b7 headpiece complexed with Fab ACT-1 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Yu, Y., Zhu, J., Springer, T.A. 3.15 X-RAY DIFFRACTION 0.251 0.220 False True IGHV1 IGKV1 Kappa None None None None None 6v6w A B 0 K protein NA envelope glycoprotein gp41 VIRAL PROTEIN/IMMUNE SYSTEM 12/06/19 Crystal structure of antibody 438-B11 DSS mutant (Cys98A-100aA) in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 6.5 X-RAY DIFFRACTION 0.355 0.309 False True unknown unknown unknown None None None None None 4nja H L 0 H Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 11/08/13 Crystal structure of Fab 6C8 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Romesberg, F.E., Zimmermann, J., Wilson, I.A. 2.204 X-RAY DIFFRACTION 0.265 0.216 False False IGHV1 IGKV3 Kappa 6.000000000000001e-07 -8.488120381868695 Unknown TBD 4jg1 H L 0 P peptide phosphopeptide immune system 02/28/13 Structure of phosphoserine/threonine (pSTAb) scaffold bound to pThr peptide ESCHERICHIA COLI; SYNTHETIC CONSTRUCT Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A. 1.55 X-RAY DIFFRACTION 0.174 0.151 False True IGHV3 IGKV3 Kappa 2.32e-07 -9.051093802733906 Unknown TBD 1mcr NA B 0 P peptide peptide n-acetyl-l-his-d-pro-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 5m2i H NA 0 A protein tumor necrosis factor CYTOKINE 10/13/16 Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.15 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 5.400000000000001e-10 -12.643277036143104 SPR TBD 1g9e A NA 14 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7dkj G H 0 E protein NA hemagglutinin VIRAL PROTEIN 11/24/20 Hemagglutinin Influenza A virus (A/Okuda/1957(H2N2) bound with a neutralizing antibody INFLUENZA A VIRUS (A/OKUDA/1957(H2N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/okuda/1957(h2n2)) Kamada, K., Shirouzu, M. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV12 Kappa None None None None None 6ev1 G H 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Dubel, S., Blankenfeldt, W., Rau, U. 3.043 X-RAY DIFFRACTION 0.238 0.186 False True IGHV1 IGKV4 Kappa None None None None None 7lu9 p o 0 P carbohydrate BMA BETA-D-MANNOSE VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta Manne, K., Edwards, R.J., Acharya, P. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 6phb B A 0 E protein 25 kda ookinete surface antigen IMMUNE SYSTEM 06/25/19 Pfs25 in complex with the human transmission blocking antibody 2530 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum McLeod, B.R., Julien, J.P. 2.0 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV1 Kappa None None None None None 5mtl NA C 0 IMMUNE SYSTEM 01/10/17 Crystal structure of an amyloidogenic light chain HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.45 X-RAY DIFFRACTION 0.277 0.234 False True IGLV1 Lambda None None None None None 3tcl A B 0 IMMUNE SYSTEM 08/09/11 Crystal Structure of HIV-1 Neutralizing Antibody CH04 HOMO SAPIENS homo sapiens homo sapiens Louder, R.K., McLellan, J.S., Pancera, M., Yang, Y., Zhang, B., Bonsignori, M., Kwong, P.D. 1.906 X-RAY DIFFRACTION 0.238 0.196 False True IGHV3 IGKV3 Kappa None None None None None 2kh2 B b 48 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5tgb H L 0 IMMUNE SYSTEM 09/27/16 Structure of chimeric 02-CB Fab, a VRC01-like germline antibody HOMO SAPIENS homo sapiens homo sapiens Pancera, M. 2.741 X-RAY DIFFRACTION 0.286 0.249 False True IGHV1 IGKV3 Kappa None None None None None 4xxd E D 0 F peptide amyloid-beta fragment IMMUNE SYSTEM 01/30/15 Crystal Structure of mid-region amyloid beta capture by solanezumab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Hermans, S.J., Crespi, G.A.N., Parker, M.W., Miles, L.A. 2.41 X-RAY DIFFRACTION 0.290 0.249 False True IGHV3 IGKV2 Kappa None None None None None 4hzl H L 0 E peptide e2 envelop protein IMMUNE SYSTEM 11/15/12 Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein MUS MUSCULUS; RECOMBINANT HEPATITIS C VIRUS H77(5'UTR-NS2)/JFH1_V787A,Q1247L mus musculus mus musculus recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l Deng, L., Zhang, P. 2.85 X-RAY DIFFRACTION 0.277 0.221 False False IGHV5 IGKV1 Kappa None None None None None 6eti D C 0 B protein atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 10/26/17 Structure of inhibitor-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Altmann, K.H., Locher, K.P. 3.1 ELECTRON MICROSCOPY False True IGHV3 IGKV13 Kappa None None None None None 3pgf H L 0 A protein maltose-binding periplasmic protein MALTODEXTRIN BINDING PROTEIN/DE NOVO PROTEIN 11/01/10 Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Kossiakoff, A.A., Duguid, E.M., Sandstrom, A. 2.1 X-RAY DIFFRACTION 0.227 0.177 False True IGHV3 IGKV1 Kappa None None None None None 1dl7 H L 0 L Hapten NCH P-NITROPHENYL-PHOSPHOCHOLINE IMMUNE SYSTEM 12/08/99 THE STRUCTURAL BASIS OF REPERTOIRE SHIFT IN AN IMMUNE RESPONSE TO PHOSPHOCHOLINE MUS MUSCULUS mus musculus mus musculus mus musculus Schumacher, M., Brown, M. 2.35 X-RAY DIFFRACTION 0.265 0.189 False True IGHV2 IGLV1 Lambda 3.2e-07 -8.86056075368313 Unknown TBD 3uze B b 0 D protein envelope protein IMMUNE SYSTEM 12/07/11 Crystal structure of the dengue virus serotype 3 envelope protein domain III in complex with the variable domains of Mab 4E11 MUS MUSCULUS; DENGUE VIRUS 3 mus musculus dengue virus 3 Cockburn, J.J.B., Navarro Sanchez, M.E., Fretes, N., Urvoas, A., Staropoli, I., Kikuti, C.M., Coffey, L.L., Arenzana Seisdedos, F., Bedouelle, H., Rey, F.A. 2.04 X-RAY DIFFRACTION 0.234 0.218 True True unknown unknown unknown 8e-09 -11.046161627732946 ELISA TBD 6ey0 G NA 0 C protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 N-terminal part (residues 30-212) of PorM with the llama naobody nb01 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Roche, J., Cambillau, C., Roussel, A. 2.4 X-RAY DIFFRACTION 0.242 0.213 False True IGHV1 None None None None None 7mhy M N 0 A protein NA protein-cysteine n-palmitoyltransferase hhat TRANSFERASE/IMMUNE SYSTEM 04/16/21 Human Hedgehog acyltransferase (HHAT) in complex with palmitoyl-CoA and two Fab antibody fragments HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Long, S.B., Jiang, Y. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7kde S T 0 A protein NA hiv-1 envelope glycoprotein bg505 sosip.664 gp41 VIRAL PROTEIN/Immune System 10/08/20 BG505 SOSIP.664 in complex with the V3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 2kh2 B b 39 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 7q9f H L 0 A protein NA surface glycoprotein Viral Protein/Immune System 11/12/21 Beta-50 fab in complex with SARS-CoV-2 beta-Spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6war P NA 0 O protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 7b2p D NA 0 B | A protein | protein NA | NA complement c4 alpha chain | complement c4 beta chain IMMUNE SYSTEM 11/27/20 Cryo-EM structure of complement C4b in complex with nanobody B5 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Oosterheert, W., De la O Becerra, K.I., Gros, P. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5ip4 B NA 0 D protein neuronal migration protein doublecortin TRANSFERASE 03/09/16 X-RAY STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Ruf, A., Benz, J., Burger, D., D'Arcy, B., Debulpaep, M., Di Lello, P., Fry, D., Huber, W., Kremer, T., Laeremans, T., Matile, H., Ross, A., Rudolph, M.G., Rufer, A.C., Sharma, A., Steinmetz, M.O., Steyaert, J., Schoch, G., Stihle, M., Thoma, R. 1.81 X-RAY DIFFRACTION 0.246 0.194 False True IGHV1 4.51e-07 -8.657252145183932 SPR TBD 6amj B A 0 IMMUNE SYSTEM 08/09/17 CAT192 Fab Wild Type HOMO SAPIENS homo sapiens homo sapiens Lord, D.M., Wei, R.R. 2.49 X-RAY DIFFRACTION 0.262 0.206 False True IGHV3 IGKV1 Kappa None None None None None 7arn H L 0 B carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 10/25/20 Crystal Structure of the Fab Fragment of a Glycosylated Lymphoma Antibody HOMO SAPIENS homo sapiens homo sapiens Pryce, R., Allen, J.D., Watanabe, Y., Crispin, M., Bowden, T.A. 1.57 X-RAY DIFFRACTION 0.232 0.195 False True IGHV3 IGKV1 Kappa None None None None None 7whk G NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 3.01 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1mrc H L 0 IMMUNOGLOBULIN 06/13/94 PREPARATION, CHARACTERIZATION AND CRYSTALLIZATION OF AN ANTIBODY FAB FRAGMENT THAT RECOGNIZES RNA. CRYSTAL STRUCTURES OF NATIVE FAB AND THREE FAB-MONONUCLEOTIDE COMPLEXES MUS MUSCULUS mus musculus mus musculus Pokkuluri, P.R., Cygler, M. 2.4 X-RAY DIFFRACTION unknown 0.191 False True IGHV1 IGKV1 Kappa None None None None None 5trp H L 0 IMMUNE SYSTEM 10/27/16 Crystal Structure of the Unliganded DH270 Cooperating Lineage Member DH272 HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 2.692 X-RAY DIFFRACTION 0.256 0.211 False True IGHV1 IGKV2 Kappa None None None None None 5k8a H L 0 IMMUNE SYSTEM 05/27/16 NIST FAB MUS MUSCULUS mus musculus mus musculus Gallagher, D.T., Galvin, C.V., Karageorgos, I., Marino, J.P. 1.999 X-RAY DIFFRACTION 0.189 0.164 False True IGHV2 IGKV1 Kappa None None None None None 6nb8 H L 0 IMMUNE SYSTEM 12/06/18 Crystal structure of anti- SARS-CoV human neutralizing S230 antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Walls, A.J., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Gopal, R., Dai, M., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.5 X-RAY DIFFRACTION 0.167 0.129 False True IGHV3 IGKV2 Kappa None None None None None 7lzp F NA 0 D protein NA botulinum neurotoxin a light chain ANTITOXIN 03/10/21 LC/A-JPU-B9-JPU-A11-JPU-G11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.86 X-RAY DIFFRACTION 0.273 0.235 False True IGHV1 NA NA None None None None None 1mak NA A 5 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4gms I M 0 C protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/16/12 Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Lee, P.S., Ekiert, D.C., Wilson, I.A. 2.95 X-RAY DIFFRACTION 0.233 0.207 False True IGHV1 IGKV6 Kappa 2e-08 -10.503274322962254 BLI TBD 7wuq N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/09/22 Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 HOMO SAPIENS; LAMA GLAMA; MUS MUSCULUS lama glama homo sapiens | homo sapiens | homo sapiens He, Q.T., Guo, S.C., Xiao, P., Sun, J.P., Yu, X., Gou, L., Kong, L.L., Zhang, L. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6xkp H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/26/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-270 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.72 X-RAY DIFFRACTION 0.269 0.220 False True IGHV3 IGLV2 Lambda None None None None None 6b9j H L 0 X protein imv membrane protein VIRAL PROTEIN/immune system 10/10/17 Structure of vaccinia virus D8 protein bound to human Fab vv138 VACCINIA VIRUS; HOMO SAPIENS homo sapiens homo sapiens vaccinia virus Zajonc, D.M. 2.9 X-RAY DIFFRACTION 0.269 0.241 False False IGHV1 IGKV3 Kappa 3.5e-10 -12.900199280360683 SPR TBD 6al1 H L 0 A protein pdz tandem fragment with pa tag insertion SIGNALING PROTEIN 09/05/18 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA12 tag inserted between the residues 181 and 184 AQUIFEX AEOLICUS VF5; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus aquifex aeolicus vf5 Tamura, R., Oi, R., Kaneko, M.K., Kato, Y., Nogi, T. 3.2 X-RAY DIFFRACTION 0.313 0.278 False True IGHV5 IGLV3 Lambda None None None None None 5xp1 NA F 0 IMMUNE SYSTEM 05/31/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 6 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.88 X-RAY DIFFRACTION 0.297 0.257 False True IGKV1 Kappa None None None None None 6xjw H L 0 A nucleic-acid NA self-alkylating ribozyme (58-mer) RNA/IMMUNE SYSTEM 06/24/20 Crystal structure of a self-alkylating ribozyme - alkylated form without biotin moiety HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens aeropyrum pernix Koirala, D., Piccirilli, J.A. 1.918 X-RAY DIFFRACTION 0.227 0.188 False True IGHV3 IGKV1 Kappa None None None None None 7cmk H L 0 A | C protein | protein NA | NA vp1 | vp3 VIRUS 07/27/20 E30 E-particle in complex with 6C5 ECHOVIRUS E30; MUS MUSCULUS mus musculus mus musculus echovirus e30 | echovirus e30 Wang, K., Zhu, F., Rao, Z., Wang, X. 3.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV4 Kappa None None None None None 5lhp B NA 0 A protein urokinase-type plasminogen activator HYDROLASE 07/12/16 The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 VICUGNA PACOS; MUS MUSCULUS vicugna pacos mus musculus Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A. 2.63 X-RAY DIFFRACTION 0.228 0.206 False True IGHV1 None None None None None 3j8z G K 0 C protein NA l1 VIRUS/IMMUNE SYSTEM 11/20/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 14 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 7xic E F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 04/12/22 S-ECD (Omicron) in complex with STS165 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Y.N., Shen, Y.P., Zhang, Y.Y., Yan, R.H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6vry H L 0 G peptide NA siv v2 peptide IMMUNE SYSTEM 02/10/20 Structure of NCI09 fab in complex with SIV V2 peptide MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta simian immunodeficiency virus Gorman, J., Ahmadi, M., Kwong, P.D. 1.4 X-RAY DIFFRACTION 0.168 0.147 False True IGHV4 IGKV3 Kappa None None None None None 7v0v A NA 1 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7rnj H L 0 B peptide NA spike glycoprotein stem helix peptide ANTIVIRAL PROTEIN, IMMUNE SYSTEM 07/29/21 S2P6 Fab fragment bound to the SARS-CoV/SARS-CoV-2 spike stem helix peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M., Sauer, M.M., Veesler, D. 2.67 X-RAY DIFFRACTION 0.274 0.235 False True IGHV1 IGKV3 Kappa None None None None None 4k94 H L 0 C | C carbohydrate | protein NAG | NA N-ACETYL-D-GLUCOSAMINE | mast/stem cell growth factor receptor kit IMMUNE SYSTEM 04/19/13 Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19 ESCHERICHIA COLI; HOMO SAPIENS homo sapiens | homo sapiens Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J. 2.4 X-RAY DIFFRACTION 0.235 0.198 False True IGHV3 IGKV1 Kappa 6.3e-10 -12.551945274084549 SPR TBD 6x18 N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 05/18/20 GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Belousoff, M.J., Zhang, X., Danev, R. 2.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5vpg D C 0 A protein der p 1 allergen HYDROLASE/IMMUNE SYSTEM 05/05/17 CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1 MUS MUSCULUS; DERMATOPHAGOIDES PTERONYSSINUS mus musculus mus musculus dermatophagoides pteronyssinus Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W. 1.95 X-RAY DIFFRACTION 0.199 0.156 False True IGHV3 IGKV14 Kappa 1.9e-08 -10.533664762780313 ITC TBD 6wgj E F 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.9 X-RAY DIFFRACTION 0.289 0.235 False True IGHV3 IGKV2 Kappa None None None None None 7jw0 H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/24/20 SARS-CoV-2 spike in complex with the S304 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Walls, A.C., Park, Y.J., Tortorici, M.A., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6hup G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 10/09/18 CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38. BOS TAURUS; HOMO SAPIENS; LAMA GLAMA lama glama bos taurus, homo sapiens | homo sapiens Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R. 3.58 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6q0l H L 0 A protein hemagglutinin IMMUNE SYSTEM 08/01/19 Inferred intermediate I-7 (I-7-1) of the human antibody lineage 652 in complex with influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) INFLUENZA A VIRUS (A/BEIJING/262/1995(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/beijing/262/1995(h1n1)) McCarthy, K.R., Harrison, S.C. 2.5 X-RAY DIFFRACTION 0.260 0.217 False True IGHV4 IGLV3 Lambda None None None None None 6kpf S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 08/15/19 Cryo-EM structure of a class A GPCR with G protein complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Li, X.T., Hua, T., Wu, L.J., Makriyannis, A., Shen, L., Wang, Y.X., Liu, Z.J. 2.9 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 1fl3 H L 0 L Hapten SPB 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID IMMUNE SYSTEM 08/11/00 CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K MUS MUSCULUS mus musculus mus musculus mus musculus Stevens, R.C., Beuscher IV, A.E. 2.45 X-RAY DIFFRACTION 0.262 0.231 False False IGHV5 IGKV2 Kappa 1.6e-07 -9.27123914600291 Unknown TBD 4wff G F 0 B protein potassium channel subfamily k member 4 METAL TRANSPORT 09/15/14 Human TRAAK K+ channel in a K+ bound nonconductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Brohawn, S.G., MacKinnon, R. 2.5 X-RAY DIFFRACTION 0.245 0.213 False True IGHV1 IGKV4 Kappa None None None None None 2qtj B M 3 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 5jz7 C D 0 A protein beta-nerve growth factor SIGNALING PROTEIN 05/16/16 NGF IN COMPLEX WITH MEDI578 scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Olsson, L.-L., Aagaard, A. 3.4 X-RAY DIFFRACTION 0.268 0.258 False True IGHV1 IGLV1 Lambda None None None None None 2r6p F G 0 C protein major envelope protein e Virus/Immune System 09/06/07 Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus. DENGUE VIRUS 2 PUERTO RICO/PR159-S1/1969; MUS MUSCULUS mus musculus mus musculus dengue virus 2 puerto rico/pr159-s1/1969 Lok, S.M., Kostyuchenko, V.K., Holdaway, H.A., Chipman, P.R., Kuhn, R.J, Rossmann, M.G 24 ELECTRON MICROSCOPY False True IGHV14 IGKV3 Kappa None None None None None 6war B NA 0 A protein spike protein VIRAL PROTEIN/IMMUNE SYSTEM 04/08/20 Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; LAMA GLAMA lama glama middle east respiratory syndrome-relatedcoronavirus Wrapp, D., Torres, G.M., McLellan, J.S. 3.4 X-RAY DIFFRACTION 0.268 0.214 False True IGHV1 None None None None None 7jtf C D 0 F protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 08/17/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM2-01 MACACA MULATTA; RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 3.35 X-RAY DIFFRACTION 0.296 0.242 False True IGHV1 IGKV1 Kappa None None None None None 7u8l H L 0 B | A protein | protein NA | NA hemagglutinin ha2 subunit | hemagglutinin ha1 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibody 31.a.83 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Zhu, X., Wilson, I.A. 4.56 X-RAY DIFFRACTION 0.305 0.300 False True IGHV3 IGKV3 Kappa None None None None None 7e5r N D 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4rir H L 0 IMMUNE SYSTEM 10/07/14 Structural Analysis of the Unmutated Ancestor of the HIV-1 Envelope V2 Region Antibody CH58 Isolated From an RV144 HIV-1 Vaccine Efficacy Trial Vaccinee and Associated with Decreased Transmission Risk HOMO SAPIENS homo sapiens homo sapiens Nicely, N.I., Wiehe, K., Kepler, T.B., Jaeger, F.H., Dennison, S.M., Liao, H.-X., Alam, S.M., Hwang, K.-K., Bonsignori, M., Rerks-Ngarm, S., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Robb, M.L., O'Connell, R.J., Michael, N.L., Kim, J.H., Haynes, B.F. 2.5 X-RAY DIFFRACTION 0.289 0.220 False True IGHV5 IGLV6 Lambda None None None None None 3o41 A B 0 C peptide fusion glycoprotein f1 IMMUNE SYSTEM/VIRAL PROTEIN 07/26/10 Crystal Structure of 101F Fab Bound to 15-mer Peptide Epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human respiratory syncytial virus a McLellan, J.S., Chen, M., Chang, J.S., Yang, Y., Kim, A., Graham, B.S., Kwong, P.D. 1.95 X-RAY DIFFRACTION 0.217 0.177 False True IGHV8 IGKV3 Kappa None None None None None 5nqw D NA 0 A protein immunoglobulin heavy constant epsilon IMMUNE SYSTEM 04/21/17 IgE-Fc in complex with single domain antibody 026 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Laursen, N.S., Jabs, F., Spillner, E., Andersen, G.R. 3.4 X-RAY DIFFRACTION 0.241 0.212 False True IGHV3 1.4e-09 -12.078842495721123 SPR TBD 6vn0 H L 0 B | A protein | protein NA | NA envelope glycoprotein gp41 | envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 01/29/20 BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Shin, M., Ward, A.B. 4.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV6 Kappa None None None None None 5d6c B A 0 B Hapten 57S 4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-5-O-phosphono-D-ribitol IMMUNE SYSTEM 08/12/15 Structure of 4497 Fab bound to synthetic wall teichoic acid fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lupardus, P.J., Fong, R. 1.72 X-RAY DIFFRACTION 0.238 0.203 False True IGHV3 IGKV4 Kappa None None None None None 3j30 F E 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab CHK152 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 7czr J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-1B8_2B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2r2h B A 0 B carbohydrate KO2 PROP-2-EN-1-YL D-GLYCERO-ALPHA-D-TALO-OCT-2-ULOPYRANOSIDONIC ACID IMMUNE SYSTEM 08/25/07 Structure of S25-2 in Complex with Ko MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V. 2.0 X-RAY DIFFRACTION 0.262 0.215 False False IGHV7 IGKV8 Kappa None None None None None 6vbp A B 0 F peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH815 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.298 X-RAY DIFFRACTION 0.229 0.180 False True IGHV5 IGKV4 Kappa None None None None None 6w09 L P 0 H protein NA e2 glycoprotein VIRUS/IMMUNE SYSTEM 02/29/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain CHIKUNGUNYA VIRUS; HOMO SAPIENS homo sapiens homo sapiens chikungunya virus Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 7lbf H G 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 01/07/21 CryoEM structure of the HCMV Trimer gHgLgO in complex with human Platelet-derived growth factor receptor alpha and neutralizing fabs 13H11 and MSL-109 HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN); HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus (strain merlin) Kschonsak, M., Rouge, L., Arthur, C.P., Hoangdung, H., Patel, N., Kim, I., Johnson, M., Kraft, E., Rohou, A.L., Gill, A., Martinez-Martin, N., Payandeh, J., Ciferri, C. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7m52 H L 0 A peptide NA spike glycoprotein stem helix peptide ANTIVIRAL PROTEIN, IMMUNE SYSTEM 03/22/21 B6 Fab fragment bound to the HKU4 spike stem helix peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus bat coronavirus hku4 Sauer, M.M., Park, Y.J., Veesler, D., Center for Structural Genomics of Infectious Diseases (CSGID) 1.5 X-RAY DIFFRACTION 0.197 0.164 False True IGHV1 IGKV8 Kappa None None None None None 1dbm H L 0 H Hapten SIH PROGESTERONE-11-ALPHA-OL-HEMISUCCINATE IMMUNOGLOBULIN 08/24/93 MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY MUS MUSCULUS mus musculus mus musculus mus musculus Arevalo, J.H., Wilson, I.A. 2.7 X-RAY DIFFRACTION unknown 0.218 False True IGHV9 IGKV1 Kappa None None None None None 7lr4 H L 0 D protein NA hapless 2 CELL ADHESION/IMMUNE SYSTEM 02/15/21 Complex of Fab 2/1.12 with domain 3 of P. berghei HAP2 MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Feng, J., Dong, X.C., Su, Y., Lu, X.F., Springer, T.A. 2.1 X-RAY DIFFRACTION 0.231 0.189 False True IGHV1 IGKV10 Kappa None None None None None 5uk4 n NA 0 N protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 5kte H L 0 A protein divalent metal cation transporter mnth TRANSPORT PROTEIN/IMMUNE SYSTEM 07/11/16 Crystal structure of Deinococcus radiodurans MntH, an Nramp-family transition metal transporter MUS MUSCULUS; DEINOCOCCUS RADIODURANS mus musculus mus musculus deinococcus radiodurans Bane, L.B., Gaudet, R., Weihofen, W.A., Singharoy, A. 3.941 X-RAY DIFFRACTION 0.313 0.268 False True IGHV2 IGKV5 Kappa None None None None None 5grw B b 0 IMMUNE SYSTEM 08/12/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.8 X-RAY DIFFRACTION 0.182 0.182 True True unknown unknown unknown None None None None None 6xcn F G 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/08/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the C105 neutralizing antibody Fab fragment (state 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.66 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 1ruk H L 0 immune system 12/11/03 Crystal structure (C) of native cationic cyclization antibody 4C6 fab at pH 4.6 with a data set collected at SSRL beamline 9-1 MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 1.4 X-RAY DIFFRACTION unknown unknown False False IGHV3 IGKV1 Kappa None None None None None 5j1t C NA 0 A | B protein | protein NA | NA torsin-1a | torsin-1a-interacting protein 2 HYDROLASE 03/29/16 TorsinAdeltaE-LULL1 complex, H. sapiens, bound to VHH-BS2 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens | homo sapiens Demircioglu, F.E., Schwartz, T.U. 1.402 X-RAY DIFFRACTION 0.177 0.148 False True IGHV1 None None None None None 5n2k J I 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 7m7g C D 0 B protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 chimera BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 4.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 6n1v g i 0 B protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 7z1d F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-H6 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Mikolajek, H., Naismith, J.H. 1.55 X-RAY DIFFRACTION 0.186 0.167 False False IGHV1 NA NA None None None None None 5nh3 H L 0 A protein activin receptor type-2a TRANSFERASE 03/21/17 CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV HOMO SAPIENS homo sapiens homo sapiens homo sapiens Scheufler, C. 2.35 X-RAY DIFFRACTION 0.208 0.166 False False IGHV1 IGLV2 Lambda 9.73e-10 -12.294413792096064 Unknown TBD 6z7w B A 0 I | J peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Human insulin in complex with the analytical antibody HUI-018 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.42 X-RAY DIFFRACTION 0.275 0.209 False True IGHV1 IGKV6 Kappa None None None None None 6d0u K L 0 J protein hemagglutinin ANTIVIRAL PROTEIN 04/11/18 Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Wu, N.C., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.268 0.254 False True IGHV3 IGKV1 Kappa None None None None None 6glw H L 0 A protein galectin-10 SUGAR BINDING PROTEIN 05/23/18 Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11 HOMO SAPIENS; LAMA GLAMA lama glama lama glama homo sapiens Verstraete, K., Verschueren, K., Savvides, S.N. 1.9 X-RAY DIFFRACTION 0.211 0.167 False True IGHV3 IGLV2 Lambda None None None None None 7pc2 I J 0 B protein NA gp120, bg505 sosip.664 t332n VIRAL PROTEIN 08/03/21 HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Fernandez, I., Bontems, F., Pehau-Arnaudet, G., Rey, F. 2.8 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 6o28 C D 0 F peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein KQPA and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 1.93 X-RAY DIFFRACTION 0.219 0.188 False True IGHV3 IGKV3 Kappa None None None None None 6azl D C 0 IMMUNE SYSTEM 09/11/17 Structure of cetuximab with aminoheptanoic acid-linked N-carboxyethylarginine meditope variant MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.482 X-RAY DIFFRACTION 0.216 0.170 False True IGHV2 IGKV5 Kappa 1.18e-05 -6.723155843448945 Unknown TBD 6obo C NA 0 A protein NA ricin a chain TOXIN 03/21/19 Ricin A chain bound to VHH antibody V6A6 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.9 X-RAY DIFFRACTION 0.244 0.207 False True IGHV1 NA NA None None None None None 5vlp H L 0 A protein proprotein convertase subtilisin/kexin type 9 HYDROLASE 04/25/17 PCSK9 complex with LDLR antagonist peptide and Fab7G7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Eigenbrot, C., Ultsch, M. 2.9 X-RAY DIFFRACTION 0.209 0.171 False True IGHV1 IGKV6 Kappa None None None None None 7k3a L K 0 E | F protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation B, fusion peptide release INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 2ojz H L 0 IMMUNE SYSTEM 01/15/07 Anti-DNA antibody ED10 MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Sanguineti, S., Wilson, I.A., de Prat-Gay, G. 2.73 X-RAY DIFFRACTION 0.264 0.201 False False IGHV1 IGKV1 Kappa None None None None None 6bqb H L 0 P peptide n-terminal junction peptide IMMUNE SYSTEM 11/27/17 MGG4 Fab in complex with peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Oyen, D., Tan, J., Lanzavecchia, A., Wilson, I.A. 1.769 X-RAY DIFFRACTION 0.196 0.166 False True IGHV3 IGKV4 Kappa None None None None None 7ly9 E I 0 D protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/06/21 Cryo-EM structure of 2909 Fab in complex with 3BNC117 Fab and CAP256.wk34.c80 SOSIP.RnS2 N160K HIV-1 Env trimer HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.91 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5t4z H L 0 H carbohydrate MAN polysaccharide IMMUNE SYSTEM 08/30/16 STRUCTURE OF THE ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 WITH FREE MAN9 GLYCAN MACACA MULATTA macaca mulatta macaca mulatta macaca mulatta Nicely, N.I., Haynes, B.F. 1.991 X-RAY DIFFRACTION 0.239 0.187 False True IGHV2 IGLV1 Lambda None None None None None 1m7i B A 0 A carbohydrate RAM polysaccharide IMMUNE SYSTEM 07/19/02 CRYSTAL STRUCTURE OF A MONOCLONAL FAB SPECIFIC FOR SHIGELLA FLEXNERI Y LIPOPOLYSACCHARIDE COMPLEXED WITH A PENTASACCHARIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Vyas, N.K., Vyas, M.N., Chervenak, M.C., Johnson, M.A., Pinto, B.M., Bundle, D.R., Quiocho, F.A. 2.5 X-RAY DIFFRACTION 0.282 0.220 False True IGHV6 IGKV1 Kappa 4e-06 -7.3641077518219635 Unknown TBD 6x4t B E 0 C protein NA icos ligand IMMUNE SYSTEM 05/23/20 Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain HOMO SAPIENS; ORECTOLOBUS MACULATUS homo sapiens homo sapiens homo sapiens Rujas, E., Sicard, T., Julien, J.P. 3.15 X-RAY DIFFRACTION 0.256 0.201 False True IGHV3 IGKV1 Kappa None None None None None 1lve NA A 0 IMMUNOGLOBULIN 07/17/96 STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.-B., Chang, C.-H. 1.95 X-RAY DIFFRACTION 0.270 0.150 False True unknown unknown unknown None None None None None 2w0l NA C 0 IMMUNE SYSTEM 08/19/08 CRYSTAL STRUCTURE OF THE MUTANT H8P FROM THE RECOMBINANT VARIABLE DOMAIN 6JAL2 HOMO SAPIENS homo sapiens RUDINO-PINERA, E., GONZALEZRUBIO-GARRIDO, P., HORJALES, E. 2.2 X-RAY DIFFRACTION 0.245 0.206 False False IGLV6 Lambda None None None None None 4xny H L 0 G protein envelope glycoprotein gp160,envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 01/16/15 Crystal structure of broadly and potently neutralizing antibody VRC08C in complex with HIV-1 clade A strain Q842.d12 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Srivatsan, S., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.217 0.182 False True unknown IGKV3 Kappa None None None None None 4h20 H L 0 IMMUNE SYSTEM 09/11/12 Crystal Structure and Computational Modeling of the Fab Fragment from the Protective anti-Ricin Monoclonal Antibody RAC18 MUS MUSCULUS mus musculus mus musculus Zhao, Z., Worthylake, D.K., LeCour Jr., L.F., Maresh, G., Pincus, S.H. 1.9 X-RAY DIFFRACTION 0.223 0.195 False False IGHV1 IGKV6 Kappa None None None None None 6x58 A B 0 E protein NA gp41 mper peptide,putative fluoride ion transporter crcb MEMBRANE PROTEIN 05/25/20 MPER-Fluc-Ec2 bound to 10E8v4 antibody HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS; ESCHERICHIA COLI homo sapiens homo sapiens human immunodeficiency virus, escherichia coli McIlwain, B.C., Stockbridge, R.B. 3.26 X-RAY DIFFRACTION 0.295 0.251 False True IGHV3 IGLV3 Lambda None None None None None 3okl B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 08/25/10 Crystal structure of S25-39 in complex with Kdo(2.8)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Blackler, R.J., Evans, S.V. 1.8 X-RAY DIFFRACTION 0.240 0.191 False False IGHV7 IGKV8 Kappa None None None None None 7m55 H L 0 A peptide NA spike glycoprotein stem helix peptide ANTIVIRAL PROTEIN, IMMUNE SYSTEM 03/22/21 B6 Fab fragment bound to the MERS-CoV spike stem helix peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Sauer, M.M., Park, Y.J., Veesler, D., Center for Structural Genomics of Infectious Diseases (CSGID), Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.4 X-RAY DIFFRACTION 0.200 0.173 False True IGHV1 IGKV8 Kappa None None None None None 4zyp F G 0 B protein fusion glycoprotein f0,fibritin IMMUNE SYSTEM 05/21/15 Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 5.5 X-RAY DIFFRACTION 0.277 0.211 False True IGHV3 IGKV1 Kappa None None None None None 3t2n I M 0 B protein serine protease hepsin HYDROLASE 07/22/11 Human hepsin protease in complex with the Fab fragment of an inhibitory antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Koschubs, T., Dengl, S., Duerr, H., Kaluza, K., Georges, G., Hartl, C., Jennewein, S., Lanzendoerfer, M., Auer, J., Stern, A., Huang, K.-S., Kostrewa, D., Ries, S., Hansen, S., Kohnert, U., Cramer, P., Mundigl, O. 2.55 X-RAY DIFFRACTION 0.275 0.242 False True IGHV7 IGLV7 Lambda 3.98e-08 -10.5 SPR 37 22132769 6vbq C D 0 K peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH822 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.116 X-RAY DIFFRACTION 0.211 0.181 False True IGHV1 IGLV3 Lambda None None None None None 6h70 D NA 0 A protein NA capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-62 and 2-fucosyllactose (2FL) NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 1.83 X-RAY DIFFRACTION 0.191 0.162 False True IGHV1 NA NA None None None None None 6ejg C c 0 A protein cd81 antigen CELL ADHESION 09/21/17 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 4 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Harris, S.F., Wong, A., Kuglstatter, A. 2.82 X-RAY DIFFRACTION 0.263 0.227 True True unknown unknown unknown 8.100000000000001e-10 -12.403045576779583 SPR TBD 2a9n I M 0 I Hapten ORE 4-(2,7-DIFLUORO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)ISOPHTHALIC ACID Immune System 07/12/05 A Mutation Designed to Alter Crystal Packing Permits Structural Analysis of a Tight-binding Fluorescein-scFv complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cambillau, C., Spinelli, S., Honegger, A., Pluckthun, A. 3.0 X-RAY DIFFRACTION 0.266 0.217 True True IGHV3 IGLV1 Lambda None None None None None 3v7a E H 0 A protein capsid IMMUNE SYSTEM 12/20/11 Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle HUMAN CALICIVIRUS; MUS MUSCULUS mus musculus mus musculus human calicivirus Hansman, G.S., Mclellan, J.S., Kwong, P.D. 3.297 X-RAY DIFFRACTION 0.283 0.227 False False IGHV1 IGKV12 Kappa None None None None None 3cdf NA E 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 3u7y H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 10/14/11 Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Diskin, R., Bjorkman, P.J. 2.4478 X-RAY DIFFRACTION 0.256 0.207 False True IGHV1 IGKV3 Kappa None None None None None 7rth R Q 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 6nb3 H L 0 C protein spike glycoprotein VIRUS 12/06/18 MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1) MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.5 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 4i3s H L 0 G protein outer domain of hiv-1 gp120 (ker2018 od4.2.2) Viral Protein/Immune System 11/26/12 Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P21 HUMAN IMMUNODEFICIENCY VIRUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus Joyce, M.G., Biertumpfel, C., Nabel, G.J., Kwong, P.D. 2.85 X-RAY DIFFRACTION 0.320 0.248 False True unknown unknown unknown None None None None None 5cin H L 0 P peptide peptide from mper region of hiv-1 env IMMUNE SYSTEM 07/13/15 Crystal Structure of non-neutralizing version of 4E10 (DeltaLoop) with epitope bound HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caaveiro, J.M.M., Rujas, E., Nieva, J.L., Tsumoto, K. 1.7 X-RAY DIFFRACTION 0.178 0.148 False True IGHV1 IGKV3 Kappa 1.8000000000000002e-08 -10.565698709005899 Unknown TBD 3sgd J I 0 IMMUNE SYSTEM 06/14/11 Crystal structure of the mouse mAb 17.2 MUS MUSCULUS mus musculus mus musculus Pizarro, J.C., Boulot, G., Hontebeyrie, M., Bentley, G.A. 2.31 X-RAY DIFFRACTION 0.235 0.172 False True IGHV10 IGKV1 Kappa None None None None None 7mly L M 0 A protein NA glycine receptor alpha 1 MEMBRANE PROTEIN, SIGNALING PROTEIN 04/29/21 Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer RATTUS NORVEGICUS; SUS SCROFA rattus norvegicus rattus norvegicus sus scrofa Zhu, H., Gouaux, E. 2.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 4ye4 H L 0 G protein ht593.1 gp120 Viral protein/Immune system 02/23/15 Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Kwong, P.D., Chen, L., Zhou, T. 2.72 X-RAY DIFFRACTION 0.242 0.187 False True unknown unknown unknown None None None None None 6wno E F 0 D protein NA plasmodium vivax reticulocyte binding protein 2b CELL INVASION 04/23/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 243244 HOMO SAPIENS; PLASMODIUM VIVAX (STRAIN SALVADOR I) homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.35 X-RAY DIFFRACTION 0.284 0.245 False True IGHV3 IGLV2 Lambda None None None None None 5ifh H L 0 IMMUNE SYSTEM 02/26/16 Crystal structure of the BCR Fab fragment from subset #2 case P11475 HOMO SAPIENS homo sapiens homo sapiens Minici, C., Degano, M. 2.293 X-RAY DIFFRACTION 0.209 0.180 False True IGHV3 IGLV3 Lambda None None None None None 7vbh N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/31/21 Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex HOMO SAPIENS; ESCHERICHIA COLI; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT homo sapiens | rattus norvegicus Zhao, F.H., Zhou, Q.T., Cong, Z.T., Hang, K.N., Zou, X.Y., Zhang, C., Chen, Y., Dai, A.T., Liang, A.Y., Ming, Q.Q., Wang, M., Chen, L.N., Xu, P.Y., Chang, R.L., Feng, W.B., Xia, T., Zhang, Y., Wu, B.L., Yang, D.H., Zhao, L.H., Xu, H.E., Wang, M.W. 3.0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6wpt D E 0 A protein sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/27/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment (open state) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., De Marco, A., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.7 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6wn4 H L 0 D peptide NA lipoprotein lipase peptide IMMUNE SYSTEM 04/22/20 Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Luz, J.G., Birrane, G., Young, S.G., Meiyappan, M., Ploug, M. 2.8 X-RAY DIFFRACTION 0.243 0.208 False False IGHV1 IGKV4 Kappa None None None None None 4n0y H L 0 A peptide hcv e1 peptide IMMUNE SYSTEM 10/02/13 Structure of the Hepatitis C Envelope Glycoprotein E1 antigenic region 314-324 bound to the cross-neutralizing antibody IGH526 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Kong, L., Wilson, I.A. 1.749 X-RAY DIFFRACTION 0.210 0.179 False True IGHV1 IGLV1 Lambda None None None None None 7cz0 F NA 0 B protein NA thermostable green fluorescent protein (tgp) FLUORESCENT PROTEIN 09/06/20 Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb92) GALAXEA FASCICULARIS; SYNTHETIC CONSTRUCT synthetic construct galaxea fascicularis Cai, H., Yao, H., Li, T., Hutter, C., Tang, Y., Li, Y., Seeger, M., Li, D. 2.77 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 NA NA None None None None None 7rth a NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 2kh2 B b 51 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 1bln B A 0 IMMUNE SYSTEM 07/16/98 ANTI-P-GLYCOPROTEIN FAB MRK-16 MUS MUSCULUS mus musculus mus musculus Vasudevan, S., Tsuruo, T., Rose, D.R. 2.8 X-RAY DIFFRACTION 0.287 0.209 False False IGHV5 IGKV1 Kappa None None None None None 3t3p H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION 07/25/11 A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Zhu, J., Zhu, J., Springer, T.A. 2.2 X-RAY DIFFRACTION 0.220 0.189 False True IGHV14 IGKV14 Kappa None None None None None 5dr5 H L 0 IMMUNE SYSTEM 09/15/15 Crystal structure of the sclerostin-neutralizing Fab AbD09097 HOMO SAPIENS homo sapiens homo sapiens Mueller, T.D., Boschert, V., Weidauer, S.E., Muth, E.M., Knappik, A., Frisch, C. 1.85 X-RAY DIFFRACTION 0.244 0.188 False True IGHV3 IGKV3D Kappa None None None None None 6xpz E F 0 D protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S1V2-83 in complex with the influenza hemagglutinin head domain of A/Moscow/10/1999(H3N2) INFLUENZA A VIRUS (A/MOSCOW/10/1999(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/moscow/10/1999(h3n2)) McCarthy, K.R., Harrison, S.C. 3.45 X-RAY DIFFRACTION 0.307 0.251 False True IGHV3 IGKV1 Kappa None None None None None 7nez F E 0 A protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 02/05/21 Structure of topotecan-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kowal, J., Locher, K., Ni, D., Stahlberg, H. 3.39 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 3c09 C B 0 A protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 01/18/08 Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR HOMO SAPIENS, MUS MUSCULUS; HOMO SAPIENS homo sapiens, mus musculus homo sapiens, mus musculus homo sapiens Ferguson, K.M., Schmiedel, J., Knoechel, T. 3.2 X-RAY DIFFRACTION 0.299 0.242 False True IGHV1 IGKV1 Kappa 4.30e-08 -10.04 SPR 25 18394559 7vfa D NA 0 E protein NA 3c-like proteinase VIRAL PROTEIN/IMMUNE SYSTEM 09/11/21 the complex of SARS-CoV2 3CL and NB1A2 CAMELUS BACTRIANUS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 camelus bactrianus severe acute respiratory syndrome coronavirus2 Sun, Z.C., Wang, L., Geng, Y. 1.75 X-RAY DIFFRACTION 0.225 0.192 False True IGHV1 NA NA None None None None None 5b8c K J 0 L protein programmed cell death protein 1 IMMUNE SYSTEM 06/14/16 High resolution structure of the human PD-1 in complex with pembrolizumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Horita, S., Shimamura, T., Iwata, S., Nomura, N. 2.146 X-RAY DIFFRACTION 0.226 0.184 False True IGHV1 IGKV3 Kappa None None None None None 6cdi 8 7 0 2 protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 5vga B A 0 IMMUNE SYSTEM 04/10/17 Alternative model for Fab 36-65 MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Rupp, B., Wlodawer, A., Dauter, Z., Porebski, P.J., Minor, W., Jaskolski, M., Pozharski, E., Weichenberger, C.X. 2.5 X-RAY DIFFRACTION 0.250 0.203 False False IGHV1 IGKV10 Kappa None None None None None 7dpm D E 0 F protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 12/20/20 Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, J., Jiao, S., Wang, R., Zhang, J., Zhang, M., Wang, M. 3.304 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGKV1 Kappa None None None None None 5yy4 A a 0 B peptide c-c chemokine receptor type 5 IMMUNE SYSTEM 12/07/17 Crystal structure of the scFv antibody 4B08 with sulfated epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.59 X-RAY DIFFRACTION 0.194 0.157 True True unknown unknown unknown 3.7e-07 -8.774542782220665 Unknown TBD 3vrl E F 0 D protein gag protein IMMUNE SYSTEM/VIRAL PROTEIN 04/12/12 Crystal structure of BMJ4 p24 capsid protein in complex with A10F9 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Gu, Y., Cao, F., Li, S., Yuan, Y.A., Xia, N. 3.2 X-RAY DIFFRACTION 0.292 0.211 False False IGHV5 IGKV12 Kappa None None None None None 5l0q F E 0 D protein disintegrin and metalloproteinase domain-containing protein10 HYDROLASE/IMMUNE SYSTEM 07/28/16 Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7. HOMO SAPIENS; BOS TAURUS homo sapiens homo sapiens bos taurus Xu, K., Saha, N., Nikolov, D.B. 2.759 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV5 Kappa None None None None None 3u36 C D 0 IMMUNE SYSTEM 10/04/11 Crystal Structure of PG9 Fab HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Kwong, P.D. 3.281 X-RAY DIFFRACTION 0.249 0.214 False True IGHV3 IGLV2 Lambda None None None None None 7t4r S R 0 K protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 12/10/21 CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11 HOMO SAPIENS; HUMAN BETAHERPESVIRUS 5 homo sapiens homo sapiens human betaherpesvirus 5 Kschonsak, M., Johnson, M.C., Schelling, R., Green, E.M., Rouge, L., Ho, H., Patel, N., Kilic, C., Kraft, E., Arthur, C.P., Rohou, A.L., Comps-Agrar, L., Martinez-Martin, N., Perez, L., Payandeh, J., Ciferri, C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 1xgt B A 0 C protein unknown protein IMMUNE SYSTEM 09/17/04 Structure for antibody HyHEL-63 Y33L mutant complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS escherichia coli Li, Y., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.287 0.252 False True IGHV3 IGKV5 Kappa None None None None None 3ehb C D 0 B protein cytochrome c oxidase subunit 2 OXIDOREDUCTASE/IMMUNE SYSTEM 09/12/08 A D-Pathway Mutation Decouples the Paracoccus Denitrificans Cytochrome c Oxidase by Altering the side chain orientation of a distant, conserved Glutamate PARACOCCUS DENITRIFICANS; MUS MUSCULUS mus musculus mus musculus paracoccus denitrificans Koepke, J., Mueller, H., Peng, G. 2.32 X-RAY DIFFRACTION 0.242 0.205 False True IGHV5 IGKV12 Kappa None None None None None 5c9k NA G 0 IMMUNE SYSTEM 06/27/15 Crystal structure of a highly fibrillogenic Arg24Gly mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Rodriguez-Romero, A., Luna-Martinez, O.D., Becerril-Lujan, B. 1.92 X-RAY DIFFRACTION 0.219 0.170 False True IGLV6 Lambda None None None None None 6rlm C D 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 6p3s F G 0 H protein hemagglutinin IMMUNE SYSTEM/VIRAL PROTEIN 05/27/20 Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 4.0 X-RAY DIFFRACTION 0.326 0.281 False True IGHV3 IGKV1 Kappa None None None None None 5wk3 S R 0 B protein c-c motif chemokine 17 IMMUNE SYSTEM 07/24/17 CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.231 0.180 False True IGHV5 IGKV4 Kappa None None None None None 6kvf A C 0 B peptide NA peptide from c-x-c chemokine receptor type 2 IMMUNE SYSTEM 09/04/19 Structure of anti-hCXCR2 abN48 in complex with its CXCR2 epitope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Xiang, J.C., Yan, L., Yang, B., Wilson, I.A. 2.79 X-RAY DIFFRACTION 0.264 0.228 False True IGHV1 IGLV5 Lambda None None None None None 1kfa H L 0 H Hapten GA4 GIBBERELLIN A4 IMMUNE SYSTEM 11/20/01 Crystal structure of Fab fragment complexed with gibberellin A4 MUS MUSCULUS mus musculus mus musculus mus musculus Murata, T., Fushinobu, S., Nakajima, M., Asami, O., Sassa, T., Wakagi, T., Yamaguchi, I. 2.8 X-RAY DIFFRACTION 0.313 0.235 False True IGHV5 IGKV1 Kappa None None None None None 4lmq H L 0 D protein stromal cell-derived factor 1 cell adhesion/immune system 07/10/13 Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhong, Z., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., Wong, T, Chiang, N.Y., Clark, S., Clark, R., Quintana, L., Gribling, P., Suto, E., Barck, K., Corpuz, R., Yao, J., Takkar, R., Lee, W.P., Damico-Beyer, L.A., Carano, R.D., Adams, C., Kelley, R.F., Wang, W., Ferrara, N. 2.773 X-RAY DIFFRACTION 0.301 0.253 False True IGHV3 IGKV1 Kappa 9.230000000000001e-10 -12.325670178389219 BLI TBD 6wg8 A B 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.36 X-RAY DIFFRACTION 0.223 0.209 False True IGHV3 IGKV2 Kappa None None None None None 6obm B NA 0 A protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V6A7 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 2.495 X-RAY DIFFRACTION 0.261 0.209 False True IGHV1 None None None None None 3q3g B A 0 E protein integrin alpha-m IMMUNE SYSTEM/CELL ADHESION 12/21/10 Crystal Structure of A-domain in complex with antibody HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mahalingam, B., Xiong, J.P., Arnaout, M.A. 2.7 X-RAY DIFFRACTION 0.244 0.211 False False IGHV14 IGKV8 Kappa 4.97e-09 -11.32 SPR 25 22095715 7kfh H K 0 B protein NA virion spike glycoprotein 1 VIRAL PROTEIN/IMMUNE SYSTEM 10/13/20 Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437 EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7rew H L 0 I protein NA il13 CYTOKINE 07/13/21 Crystal Structure of IL-13 in complex with MMAb3 Fab HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Sudom, A., Min, X. 2.1 X-RAY DIFFRACTION 0.291 0.245 False True IGHV3 IGLV3 Lambda None None None None None 7rcs A B 0 D peptide NA circumsporozoite protein IMMUNE SYSTEM 07/08/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.160 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.253 0.188 False True IGHV1 IGKV4 Kappa None None None None None 1fl5 B A 0 IMMUNE SYSTEM 08/11/00 THE UNLIGANDED GERMLINE PRECURSOR TO THE SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4. MUS MUSCULUS; HOMO SAPIENS homo sapiens mus musculus Yin, J., Mundorff, E.C., Yang, P.L., Wendt, K.U., Hanway, D., Stevens, R.C., Schultz, P.G. 2.1 X-RAY DIFFRACTION 0.268 0.226 False True IGHV7 IGKV1 Kappa None None None None None 7t8w H L 0 D peptide NA mature secreted glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 12/17/21 Structure of antibody 3G12 bound to Respiratory Syncytial Virus G central conserved domain mutant S177Q HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A2 homo sapiens homo sapiens human respiratory syncytial virus a2 Nunez Castrejon, A.M., O'Rourke, S.M., Kauvar, L.M., DuBois, R.M. 3.1 X-RAY DIFFRACTION 0.250 0.237 False True IGHV4 IGKV3 Kappa None None None None None 4y5y D E 0 F protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 330 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 2.85 X-RAY DIFFRACTION 0.241 0.221 False True IGHV3 IGLV2 Lambda None None None None None 6x3u K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 3.49 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 43ca B A 0 A Hapten NPO P-NITROPHENOL IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY WITH BOUND P-NITROPHENOL MUS MUSCULUS mus musculus mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.3 X-RAY DIFFRACTION 0.259 0.206 False True IGHV2 IGKV8 Kappa None None None None None 6p9h C D 0 B protein iron-regulated heme-iron binding protein IMMUNE SYSTEM 06/17/20 Crystal structure of human anti staphylococcus aureus antibody STAU-281 Fab in complex with IsdB NEAT2 domain STAPHYLOCOCCUS AUREUS; HOMO SAPIENS homo sapiens homo sapiens staphylococcus aureus Dong, J., Crowe, J.E. 3.003 X-RAY DIFFRACTION 0.225 0.206 False True IGHV1 IGKV3 Kappa None None None None None 7tlz B A 0 J protein NA spike glycoprotein VIRUS/IMMUNE SYSTEM 01/19/22 SARS-CoV-2 S NTD B.1.1.529 Omicron variant + S309 Local Refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 1dcl NA A 0 IMMUNOGLOBULIN 10/16/95 MCG, A LAMBDA V TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN), CRYSTALLIZED FROM AMMONIUM SULFATE HOMO SAPIENS homo sapiens Schiffer, M., Xu, Z.B. 2.3 X-RAY DIFFRACTION unknown 0.140 False False IGLV2 Lambda None None None None None 6jb9 A NA 0 IMMUNE SYSTEM 01/25/19 Crystal structure of nanobody D3-L11 (unbound form) CAMELUS DROMEDARIUS camelus dromedarius Caaveiro, J.M.M., Tamura, H., Akiba, H., Tsumoto, K. 1.15 X-RAY DIFFRACTION 0.129 0.102 False True IGHV1 None None None None None 7pr0 G F 0 D protein NA spike protein s1 VIRAL PROTEIN 09/20/21 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with FD-5D Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.92 X-RAY DIFFRACTION 0.251 0.214 False True IGHV3 IGKV2 Kappa None None None None None 1jn6 B A 0 IMMUNE SYSTEM 07/23/01 Crystal Structure of Fab-Estradiol Complexes MUS MUSCULUS mus musculus mus musculus Monnet, C., Bettsworth, F., Stura, E.A., Le Du, M.-H., Menez, R., Derrien, L., Zinn-Justin, S., Gilquin, B., Sibai, G., Battail-Poirot, N., Jolivet, M., Menez, A., Arnaud, M., Ducancel, F., Charbonnier, J.B. 2.7 X-RAY DIFFRACTION 0.305 0.223 False False IGHV1 IGLV1 Lambda None None None None None 4llv C D 0 IMMUNE SYSTEM 07/09/13 The structure of the unbound form of anti-HIV antibody 4E10 Fv HOMO SAPIENS homo sapiens homo sapiens Finton, K.A.K., Rupert, P.B., Strong, R.K. 2.39 X-RAY DIFFRACTION 0.245 0.216 False True IGHV1 IGKV3 Kappa None None None None None 2q1e NA A 0 PROTEIN FIBRIL 05/24/07 Altered dimer interface decreases stability in an amyloidogenic kappa1 Bence Jones protein. HOMO SAPIENS homo sapiens Thompson, J.R., Ramirez-Alvarado, M., Baden, E.M. 2.55 X-RAY DIFFRACTION 0.206 0.165 False True IGKV1 Kappa None None None None None 3chn B M 7 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 4xnx H L 0 A protein transporter transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter in complex with reboxetine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Aravind, P., Wang, K., Gouaux, E. 3.0 X-RAY DIFFRACTION 0.258 0.217 False True IGHV5 IGKV4 Kappa None None None None None 1vhp A NA 19 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5h30 G H 0 A protein structural protein e VIRUS/IMMUNE SYSTEM 10/19/16 Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Zhang, S., Kostyuchenko, V., Ng, T.-S., Lok, S.-M. 4.4 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 3ngb E F 0 D protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/10 Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.68 X-RAY DIFFRACTION 0.256 0.197 False True IGHV1 IGKV3 Kappa 7.70e-09 -10.88 SPR 20 20616231 1fj1 D C 0 E protein outer surface protein a IMMUNE SYSTEM 08/07/00 LYME DISEASE ANTIGEN OSPA IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB LA-2 BORRELIA BURGDORFERI; MUS MUSCULUS mus musculus mus musculus borrelia burgdorferi Ding, W., Lawson, C.L. 2.68 X-RAY DIFFRACTION 0.281 0.226 False False IGHV9 IGKV19 Kappa None None None None None 5w08 M N 0 F protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 05/30/17 A/Texas/50/2012(H3N2) Influenza hemagglutinin in complex with K03.12 Fab INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 2.6 X-RAY DIFFRACTION 0.262 0.240 False True IGHV1 IGLV2 Lambda 4e-08 -10.092595930642474 SPR TBD 6h15 D NA 0 B protein low-density lipoprotein receptor-related protein 6 SIGNALING PROTEIN 07/11/18 Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Gros, P., van Scherpenzeel, R.C. 2.6 X-RAY DIFFRACTION 0.247 0.198 False True IGHV1 None None None None None 3b9v C NA 0 IMMUNE SYSTEM 11/06/07 Crystal Structure of an Autonomous VH Domain HOMO SAPIENS homo sapiens Appleton, B.A., Barthelemy, P.A., Wiesmann, C. 1.8 X-RAY DIFFRACTION 0.200 0.155 False True IGHV3 None None None None None 4rgm H L 0 S protein enterotoxin type b TOXIN/IMMUNE SYSTEM 09/30/14 Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 20B1 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Franklin, M.C., Dutta, K., Varshney, A.K., Goger, M.J., Fries, B.C. 2.689 X-RAY DIFFRACTION 0.277 0.225 False False IGHV9 IGKV9 Kappa 2.29e-08 -10.423049285339754 BLI TBD 4ag4 H L 0 A protein epithelial discoidin domain-containing receptor 1 IMMUNE SYSTEM/TRANSFERASE 01/24/12 Crystal structure of a DDR1-Fab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Carafoli, F., Mayer, M.C., Shiraishi, K., Pecheva, M.A., Chan, L.Y., Nan, R., Leitinger, B., Hohenester, E. 2.8 X-RAY DIFFRACTION 0.2855 0.2156 False False IGHV1 IGKV4 Kappa None None None None None 7m6g R S 0 B protein NA spike glycoprotein VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, BG7-15 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3bz4 B A 0 B carbohydrate RAM polysaccharide IMMUNE SYSTEM 01/17/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag decasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.230 0.176 False False IGHV6 IGKV2 Kappa None None None None None 5ivz D C 0 IMMUNE SYSTEM 03/21/16 Cetuximab Fab in complex with Arg8Cir meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.230 0.176 False True IGHV2 IGKV5 Kappa None None None None None 5m30 E NA 0 A protein type vi secretion protein SECRETION SYSTEM 10/13/16 Structure of TssK from T6SS EAEC in complex with nanobody nb18 VICUGNA PACOS; ESCHERICHIA COLI vicugna pacos escherichia coli Nguyen, V.S., Cambillau, C., Spinelli, C., Desmyter, A., Legrand, P., Cascales, E. 2.6 X-RAY DIFFRACTION 0.226 0.207 False True IGHV1 None None None None None 5m2m D NA 0 B protein tumor necrosis factor CYTOKINE 10/13/16 Complex between human TNF alpha and Llama VHH3 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.3 X-RAY DIFFRACTION 0.248 0.211 False True IGHV1 1.5000000000000002e-09 -12.037965345328766 SPR TBD 2p46 D NA 0 C protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: se5b-ortho-2 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.299 0.221 False True IGHV1 1.16e-07 -9.61 Other 30 18445622 5voc H L 0 D | B protein | protein NA | NA envelope glycoprotein ul130 | envelope glycoprotein l Viral Protein/Immune System 05/02/17 Crystal structure of HCMV Pentamer in complex with neutralizing antibody 8I21 - Low resolution dataset for initial phasing by SAD HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS; HUMAN CYTOMEGALOVIRUS (STRAIN 5508); HUMAN CYTOMEGALOVIRUS (STRAIN AD169); HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN) homo sapiens homo sapiens human cytomegalovirus (strain merlin) | human cytomegalovirus (strain 5508) Malito, E., Chandramouli, S. 3.99 X-RAY DIFFRACTION 0.276 0.259 False True IGHV3 IGKV3 Kappa None None None None None 3liz H L 0 A protein aspartic protease bla g 2 hydrolase/immune system 01/25/10 crystal structure of bla g 2 complexed with Fab 4C3 BLATTELLA GERMANICA; MUS MUSCULUS mus musculus mus musculus blattella germanica Li, M., Gustchina, A., Glesner, J., Wunschmann, S., Pomes, A., Wlodawer, A. 1.8 X-RAY DIFFRACTION 0.202 0.177 False False IGHV5 IGKV14 Kappa None None None None None 6z2m D NA 0 A protein spike glycoprotein VIRAL PROTEIN 06/03/20 H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Naismith, J.H., Ren, J., Zhou, D., Zhao, Y., Stuart, D.I. 2.71 X-RAY DIFFRACTION 0.241 0.198 False True IGHV1 None None None None None 7tee M N 0 B protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 Non-active2-like RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Furukawa, H. 6.59 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV19 Kappa None None None None None 7ryu H L 0 NA NA NA NA IMMUNE SYSTEM 08/26/21 Anti-HIV neutralizing antibody Ab1303 Fab isolated from sequentially immunized mcaques MACACA MULATTA macaca mulatta macaca mulatta Yang, Z., Bjorkman, P.J. 1.51 X-RAY DIFFRACTION 0.200 0.180 False True IGHV4 IGLV4 Lambda None None None None None 5y0a H L 0 C protein protein e VIRUS/IMMUNE SYSTEM 07/15/17 Cryo-EM structure of zika virus complexed with Fab of ZKA190 at pH 8.0 and 37 celsius degree ZIKA VIRUS (STRAIN MR 766); HOMO SAPIENS homo sapiens homo sapiens zika virus (strain mr 766) Wang, J.Q., Lok, S.M. 22 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 6fyu F NA 0 E | D protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/12/18 Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36 INFLUENZA A VIRUS; LAMA GLAMA lama glama influenza a virus | influenza a virus Laursen, N.S., Wilson, I.A. 2.643 X-RAY DIFFRACTION 0.216 0.186 False True IGHV1 NA NA None None None None None 6p4a H L 0 C protein lysozyme c HYDROLASE/IMMUNE SYSTEM 05/27/20 HyHEL10 Fab complexed with hen egg lysozyme carrying two mutations (HEL2x-rigid): R21Q and R73E MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Langley, D.B., Christ, D. 2.2 X-RAY DIFFRACTION 0.292 0.229 False True IGHV3 IGKV5 Kappa None None None None None 5ysl C D 0 IMMUNE SYSTEM 11/14/17 Crystal structure of antibody 1H1 Fab MUS MUSCULUS mus musculus mus musculus Hu, X.L., Yang, F.L. 2.5 X-RAY DIFFRACTION 0.273 0.212 False True IGHV1 IGKV4 Kappa None None None None None 6xc3 B A 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 06/08/20 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.1 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Liu, H., Wu, N.C., Zhu, X., Wilson, I.A. 2.698 X-RAY DIFFRACTION 0.225 0.177 False True IGHV3 IGKV1 Kappa None None None None None 6wqo B C 0 A protein NA reticulocyte binding protein 2b CELL INVASION 04/29/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 283284 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.15 X-RAY DIFFRACTION 0.305 0.254 False True IGHV4 IGKV1 Kappa None None None None None 7exd E e 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 05/27/21 Lasmiditan-bound serotonin 1F (5-HT1F) receptor-Gi protein complex HOMO SAPIENS; MUS MUSCULUS; ESCHERICHIA COLI mus musculus homo sapiens | homo sapiens | homo sapiens Huang, S., Xu, P., Jiang, Y., Xu, H.E. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4kk8 C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148Q mutant of CLC-ec1 deltaNC construct in 100mM fluoride ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.86 X-RAY DIFFRACTION 0.256 0.210 False True IGHV4 IGKV4 Kappa None None None None None 7a5v O NA 0 A protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 08/22/20 CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Nakane, T., Kotecha, A., Sente, A., Yamashita, K., McMullan, G., Masiulis, S., Brown, P.M.G.E., Grigoras, I.T., Malinauskaite, L., Malinauskas, T., Miehling, J., Yu, L., Karia, D., Pechnikova, E.V., de Jong, E., Keizer, J., Bischoff, M., McCormack, J., Tiemeijer, P., Hardwick, S.W., Chirgadze, D.Y., Murshudov, G., Aricescu, A.R., Scheres, S.H.W. 1.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1sm3 H L 0 P peptide peptide epitope COMPLEX (ANTIBODY/PEPTIDE EPITOPE) 12/23/97 CRYSTAL STRUCTURE OF THE TUMOR SPECIFIC ANTIBODY SM3 COMPLEX WITH ITS PEPTIDE EPITOPE MUS MUSCULUS mus musculus mus musculus Dokurno, P., Bates, P.A., Band, H.A., Stewart, L.M.D., Lally, J.M., Burchell, J.M., Taylor-Papadimitriou, J., Sternberg, M.J.E., Snary, D., Freemont, P.S. 1.95 X-RAY DIFFRACTION 0.283 0.213 False False IGHV6 IGLV1 Lambda 2.4e-05 -6.30251950781888 Unknown TBD 6n6b K L 0 A protein neuraminidase VIRAL PROTEIN/Immune System 11/26/18 The complex crystal structure of neuraminidase from A/Minnesota/11/2010 with B10 antibody. INFLUENZA A VIRUS (A/MINNESOTA/11/2010(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/minnesota/11/2010(h3n2)) Yang, H., Stevens, J. 2.3 X-RAY DIFFRACTION 0.245 0.220 False True IGHV3 IGKV6 Kappa None None None None None 7l7e A B 0 G protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV1 IGKV3 Kappa None None None None None 6o39 B A 0 C protein frizzled-5 SIGNALING PROTEIN 02/26/19 Crystal structure of Frizzled 5 CRD in complex with F2.I Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Raman, S., Beilschmidt, M., Fransson, J., Julien, J.P. 1.8 X-RAY DIFFRACTION 0.234 0.196 False True IGHV3 IGKV1 Kappa None None None None None 6vkn H L 0 A | E protein | protein NA | NA envelope glycoprotein gp160 | bg505 sosipv5.2 gp41 VIRAL PROTEIN/Immune System 01/21/20 BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7zfb A B 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with nanobody C1, Omi-18 and Omi-31 Fabs LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.08 X-RAY DIFFRACTION 0.308 0.261 False True IGHV1 IGLV1 Lambda None None None None None 6vyv J N 0 G protein NA e2 glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/27/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain ROSS RIVER VIRUS (STRAIN T48); HOMO SAPIENS homo sapiens homo sapiens ross river virus (strain t48) Miller, A.S., Kuhn, R.J. 6.33 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 7k76 A B 0 P peptide NA pfcsp n-terminal peptide p17 IMMUNE SYSTEM 09/22/20 Crystal structure of MAD2-6 IgG Fab in complex with PfCSP N-terminal peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Wilson, I.A. 2.14 X-RAY DIFFRACTION 0.218 0.184 False True IGHV4 IGKV1 Kappa None None None None None 1yej H L 0 L Hapten PNF 6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID IMMUNE SYSTEM 08/13/98 CATALYTIC ANTIBODY COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Knossow, M. 1.85 X-RAY DIFFRACTION 0.246 0.212 False False IGHV1 IGKV1 Kappa 3.5e-08 -10.171711101540176 Unknown TBD 7li8 B C 0 A protein NA sodium-dependent serotonin transporter MEMBRANE PROTEIN 01/26/21 apo serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in inward open conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Gouaux, E. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7m1h B NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/13/21 Crystal structure of LC/A-JPU-C10-JPU-D12-JPU-B8-JPU-G3-ciA-F12-ciA-D12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.78 X-RAY DIFFRACTION 0.249 0.217 False True IGHV1 NA NA None None None None None 6yxl H L 0 NA NA NA NA IMMUNE SYSTEM 05/03/20 Crystal structure of ACPA F3 HOMO SAPIENS Ge, C., Holmdahl, R. 2.1 X-RAY DIFFRACTION 0.231 0.199 False False IGHV1 IGKV3 Kappa None None None None None 4tnv Y g 0 T protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False unknown unknown unknown None None None None None 5c0n H L 0 A protein fatty acid-binding protein, adipocyte LIPID TRANSPORT 06/12/15 Development of a monoclonal antibody targeting secreted aP2 to treat diabetes and fatty liver disease ORYCTOLAGUS CUNICULUS; MUS MUSCULUS oryctolagus cuniculus oryctolagus cuniculus mus musculus Doyle, C. 3.0 X-RAY DIFFRACTION 0.265 0.186 False True IGHV1 IGKV1 Kappa 4.129999999999999e-06 -7.34515831911734 SPR TBD 6xtg H L 0 A carbohydrate NAG N-ACETYL-D-GLUCOSAMINE ANTITUMOR PROTEIN 01/16/20 Ab 1116NS19.9 bound to CA19-9 MUS MUSCULUS mus musculus mus musculus Diskin, R., Borenstein-Katz, A. 1.55 X-RAY DIFFRACTION 0.201 0.174 False True IGHV6 IGKV14 Kappa None None None None None 3f7y A B 0 C protein voltage-gated potassium channel membrane protein/metal transport 11/10/08 KcsA Potassium channel in the partially open state with 17 A opening at T112 STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 3.4 X-RAY DIFFRACTION 0.274 0.263 False False IGHV1 IGKV5 Kappa None None None None None 4yx2 H L 0 A protein major prion protein IMMUNE SYSTEM 03/22/15 Crystal structure of Bovine prion protein complexed with POM1 FAB MUS MUSCULUS; BOS TAURUS mus musculus mus musculus bos taurus Baral, P.K., Swayampakula, M., James, M.N.G. 2.194 X-RAY DIFFRACTION 0.263 0.216 False True IGHV1 IGKV5 Kappa None None None None None 1ynt D C 0 G protein major surface antigen p30 IMMUNE SYSTEM 01/25/05 Structure of the immunodominant epitope displayed by the surface antigen 1 (SAG1) of Toxoplasma gondii complexed to a monoclonal antibody FINEGOLDIA MAGNA; TOXOPLASMA GONDII; MUS MUSCULUS mus musculus mus musculus toxoplasma gondii Graille, M., Stura, E.A., Bossus, M., Muller, B.H., Letourneur, O., Battail-Poirot, N, Sibai, G., Rolland, D., Le Du, M.H., Ducancel, F. 3.1 X-RAY DIFFRACTION 0.283 0.241 False False IGHV1 IGKV10 Kappa None None None None None 3idg B A 0 C peptide gp41 mper peptide IMMUNE SYSTEM 07/21/09 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWD HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.P., Bryson, S., Pai, E.F. 1.86 X-RAY DIFFRACTION 0.227 0.224 False False IGHV2 IGKV1 Kappa None None None None None 7dcx A F 0 C protein NA sars-cov2 s protein VIRAL PROTEIN 10/27/20 S-3C1-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 3C1 fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 5.9 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 4hie B A 0 IMMUNE SYSTEM 10/11/12 Anti-Streptococcus pneumoniae 23F Fab 023.102 HOMO SAPIENS homo sapiens homo sapiens Bryson, S., Risnes, L, Damgupta, S, Thomson, C.A., Schrader, J.W., Pai, E.F. 1.9 X-RAY DIFFRACTION 0.243 0.218 False True IGHV3 IGKV3 Kappa None None None None None 3bd3 NA B 0 IMMUNE SYSTEM 11/14/07 Crystal structure of single domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals MUS MUSCULUS mus musculus Park, S.K., Kim, J.S. 1.6 X-RAY DIFFRACTION 0.270 0.229 True True IGKV8 Kappa None None None None None 5tih H L 0 A protein cysteine-rich protective antigen IMMUNE SYSTEM 10/03/16 Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Chen, L., Xu, Y., Wang, W., Thompson, J.K., Goddard-Borger, E., Lawrence, M.C., Cowman, A.F. 2.44 X-RAY DIFFRACTION 0.212 0.189 False True IGHV1 IGKV9 Kappa None None None None None 7p5y L NA 0 F protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb3 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7wwm J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 02/13/22 S protein of Delta variant in complex with ZWC6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7fjo F G 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/04/21 Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with three T6 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Zhang, S., Liang, Q. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 4ocx H L 0 L Hapten MT1 N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID IMMUNE SYSTEM 01/09/14 Fab complex with methotrexate MUS MUSCULUS mus musculus mus musculus mus musculus Longenecker, K.L., Judge, R.A., Gayda, S., Manoj, S., Saldana, S., Ruan, Q., Swift, K., Tetin, S. 2.39 X-RAY DIFFRACTION 0.216 0.187 False True IGHV3 IGKV1 Kappa None None None None None 4gms H L 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/16/12 Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Lee, P.S., Ekiert, D.C., Wilson, I.A. 2.95 X-RAY DIFFRACTION 0.233 0.207 False True IGHV1 IGKV6 Kappa 2e-08 -10.503274322962254 BLI TBD 6v8z I L 0 G protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 2.9 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7kn3 M N 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-B8 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Zhu, X., Wilson, I.A. 2.251 X-RAY DIFFRACTION 0.222 0.186 False True IGHV3 IGKV4 Kappa None None None None None 7tus C D 0 NA NA NA NA IMMUNE SYSTEM 02/03/22 Sculpting a uniquely reactive cysteine residue for site-specific antibody conjugation HOMO SAPIENS homo sapiens homo sapiens Park, H., Rader, C. 2.4 X-RAY DIFFRACTION 0.257 0.218 False True IGHV6 IGKV1 Kappa None None None None None 4b5e B NA 0 IMMUNE SYSTEM 08/03/12 Crystal Structure of an amyloid-beta binding single chain antibody PS2-8 LAMA GLAMA lama glama Beringer, D.X., Dorresteijn, B., Rutten, L., Wienk, H., el Khattabi, M., Kroon-Batenburg, L.M.J., Verrips, C.T. 1.936 X-RAY DIFFRACTION 0.2356 0.1812 False True IGHV1 None None None None None 6ot1 M N 0 D protein envelope glycoprotein gp41 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 7ew5 H I 0 D protein NA major capsid protein l1 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 5w08 Q R 0 D protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 05/30/17 A/Texas/50/2012(H3N2) Influenza hemagglutinin in complex with K03.12 Fab INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 2.6 X-RAY DIFFRACTION 0.262 0.240 False True IGHV1 IGLV2 Lambda 4e-08 -10.092595930642474 SPR TBD 5zia H I 0 J peptide phosphorylated tau peptide IMMUNE SYSTEM 03/14/18 Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, H., Wilson, I.A. 2.603 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGKV4 Kappa 3e-07 -8.898798774188476 Unknown TBD 6rcv E D 0 A protein reticulocyte binding protein homologue 5 CELL ADHESION 04/11/19 PfRH5 bound to monoclonal antibodies R5.011 and R5.016 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Alanine, D.W.G., Draper, S.J., Higgins, M.K. 3.582 X-RAY DIFFRACTION 0.305 0.280 False True IGHV1 IGKV1 Kappa None None None None None 2vdn H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.9 X-RAY DIFFRACTION 0.213 0.163 False False IGHV14 IGKV14 Kappa None None None None None 3jab Q R 0 O protein phosphodiesterase 5/6 chimera catalytic domain HYDROLASE/IMMUNE SYSTEM 05/26/15 Domain organization and conformational plasticity of the G protein effector, PDE6 BOS TAURUS; MUS MUSCULUS mus musculus mus musculus bos taurus Zhang, Z., He, F., Constantine, R., Baker, M.L., Baehr, W., Schmid, M.F., Wensel, T.G., Agosto, M.A. 11 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa None None None None None 6v80 E NA 0 A | C protein | protein NA | NA antigen-presenting glycoprotein cd1d | t cell receptor alpha variable 10, nkt tcr alpha chainfusion IMMUNE SYSTEM 12/10/19 Crystal structure of human CD1d presenting alpha-Galactosylceramide in complex with NKT12 TCR and VHH nanobody 1D12 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Shahine, A., Rossjohn, J. 3.53 X-RAY DIFFRACTION 0.254 0.195 False True IGHV1 NA NA None None None None None 4xcy G I 0 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidylglycerol (06:0 PG) HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 3.96 X-RAY DIFFRACTION 0.291 0.244 False True IGHV1 IGKV3 Kappa None None None None None 7wpf X Y 0 A protein NA spike glycoprotein VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7scg E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 09/28/21 FH210 bound Mu Opioid Receptor-Gi Protein Complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Wang, H., Kobilka, B. 3 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2gsi D C 0 X peptide thermonuclease IMMUNE SYSTEM 04/26/06 Crystal Structure of a Murine Fab in Complex with an 11 Residue Peptide Derived from Staphylococcal Nuclease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Armstrong, A.A., Amzel, L.M. 2.81 X-RAY DIFFRACTION 0.293 0.221 False False IGHV14 IGKV3 Kappa None None None None None 5vvf H L 0 IMMUNE SYSTEM 05/19/17 Crystal Structure of 354BG1 Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Gristick, H.B., Bjorkman, P.J. 2.0 X-RAY DIFFRACTION 0.247 0.210 False True unknown IGKV1 Kappa None None None None None 1bre NA F 0 IMMUNOGLOBULIN 07/19/95 IMMUNOGLOBULIN LIGHT CHAIN PROTEIN HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 2.0 X-RAY DIFFRACTION 0.337 0.218 False True IGKV1 Kappa None None None None None 1gaf H L 0 H Hapten NPE 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID CATALYTIC ANTIBODY 02/06/96 48G7 HYBRIDOMA LINE FAB COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wedemayer, G.J., Patten, P.A., Stevens, R.C., Schultz, P.G. 1.95 X-RAY DIFFRACTION 0.307 0.244 False True IGHV14 IGKV9 Kappa 1e-08 -10.913952715282035 Unknown TBD 5vk2 H L 0 a | A protein | protein NA | NA unknown | pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/Immune system 04/20/17 Structural basis for antibody-mediated neutralization of Lassa virus LASSA VIRUS; LASSA VIRUS (STRAIN MOUSE/SIERRA LEONE/JOSIAH/1976); HOMO SAPIENS homo sapiens homo sapiens lassa virus (strain mouse/sierraleone/josiah/1976) | lassa virus Hastie, K.M., Zandonatti, M.A., Kleinfelter, L.M., Rowland, M.L., Rowland, M.M., Chandra, K., Branco, L.M., Robinson, J.E., Garry, R.F., Saphire, E.O. 3.201 X-RAY DIFFRACTION 0.231 0.189 False True IGHV3 IGLV2 Lambda None None None None None 7o9w C B 0 A protein NA multidrug resistance protein 1 TRANSPORT PROTEIN 04/17/21 Encequidar-bound human P-glycoprotein in complex with UIC2-Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nosol, K., Locher, K.P. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5myx D C 0 F peptide pyroglutamate-abeta pe3-18 IMMUNE SYSTEM 01/30/17 Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Parthier, C., Piechotta, A., Stubbs, M.T. 1.492 X-RAY DIFFRACTION 0.213 0.181 False True IGHV1 IGKV1 Kappa 6.85e-09 -11.13811088195787 Unknown TBD 2dqg H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/25/06 Crystal structure of hyhel-10 FV mutant (Hy53f) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 2.3 X-RAY DIFFRACTION 0.254 0.203 False True IGHV3 IGKV5 Kappa None None None None None 6quz E NA 0 B | A protein | protein NA | NA uncharacterized abc transporter atp-binding proteintm_0288 | abc transporter, atp-binding protein MEMBRANE PROTEIN 03/01/19 Structure of ATPgS-bound outward-facing TM287/288 in complex with sybody Sb_TM35 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); SYNTHETIC CONSTRUCT synthetic construct thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) | thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 3.21 X-RAY DIFFRACTION 0.263 0.243 False True IGHV1 NA NA None None None None None 4lgs B NA 0 A protein NA ricin HYDROLASE/IMMUNE SYSTEM 06/28/13 Ricin A chain bound to camelid nanobody (VHH4) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Cheung, J., Franklin, M., Burshteyn, F., Cassidy, M., Gary, E., Mantis, N. 2.7 X-RAY DIFFRACTION 0.248 0.200 False True IGHV1 NA NA None None None None None 6oej B C 0 A protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 03/27/19 CRYSTAL STRUCTURE OF THE NON-NEUTRALIZING AND ADCC-POTENT ANTIBODY C11 IN COMPLEX WITH HIV-1 CLADE A/E GP120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 3.45 X-RAY DIFFRACTION 0.284 0.231 False True IGHV3 IGKV2 Kappa None None None None None 5jof H L 0 IMMUNE SYSTEM 05/02/16 Crystal structure of VRC03 gHVgLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 3.208 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 IGKV3 Kappa None None None None None 1pg7 X W 0 IMMUNE SYSTEM 05/27/03 Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab SYNTHETIC CONSTRUCT; MUS MUSCULUS mus musculus mus musculus Eigenbrot, C., Meng, Y.G., Krishnamurthy, R., Lipari, M.T., Presta, L., Devaux, B., Wong, T., Moran, P., Bullens, S., Kirchhofer, D. 2.5 X-RAY DIFFRACTION 0.265 0.217 False False IGHV1 IGLV1 Lambda None None None None None 1fsk F E 0 D protein major pollen allergen bet v 1-a IMMUNE SYSTEM 09/11/00 COMPLEX FORMATION BETWEEN A FAB FRAGMENT OF A MONOCLONAL IGG ANTIBODY AND THE MAJOR ALLERGEN FROM BIRCH POLLEN BET V 1 BETULA PENDULA; MUS MUSCULUS mus musculus mus musculus betula pendula Mirza, O., Henriksen, A., Ipsen, H., Larsen, J., Wissenbach, M., Spangfort, M., Gajhede, M. 2.9 X-RAY DIFFRACTION 0.285 0.253 False True IGHV1 IGKV6 Kappa 2.4e-10 -13.12373995487015 Unknown TBD 4mhh J K 0 A protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/Viet Nam/1203/2004 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 3.564 X-RAY DIFFRACTION 0.238 0.201 False True IGHV1 IGKV3 Kappa 9.000000000000001e-10 -12.340621190735936 BLI TBD 6m3z H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 03/04/20 X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in milnacipran bound form DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Shabareesh, P., Mallela, A.K., Joseph, D., Penmatsa, A. 3.11 X-RAY DIFFRACTION 0.264 0.222 False True IGHV5 IGKV4 Kappa None None None None None 2kqn NA B 16 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6hhu H NA 0 A protein s-layer protein sap STRUCTURAL PROTEIN 08/29/18 Structure of the Bacillus anthracis Sap S-layer assembly domain BACILLUS ANTHRACIS; LAMA GLAMA lama glama bacillus anthracis Remaut, H., Fioravanti, A. 2.7 X-RAY DIFFRACTION 0.250 0.186 False True IGHV3 None None None None None 7tcc O P 0 C protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6wix H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/10/20 Crystal Structure of HIV-1 MI369 RnS-DS.SOSIP Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Olia, A., Kwong, P.D. 2.67 X-RAY DIFFRACTION 0.270 0.225 False True IGHV4 unknown unknown None None None None None 5ojm N NA 0 D protein human gabaa receptor chimera beta3-alpha5,gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 07/21/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 SYNTHETIC CONSTRUCT; HOMO SAPIENS; LAMA GLAMA lama glama synthetic construct, homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.3 X-RAY DIFFRACTION 0.250 0.234 False True IGHV1 None None None None None 6u3z A B 0 IMMUNE SYSTEM 08/22/19 Structure of VD20_5A4 Fab MACACA MULATTA macaca mulatta macaca mulatta Dionne, G., Shapiro, L. 1.99002 X-RAY DIFFRACTION 0.236 0.199 False True IGHV4 IGKV1 Kappa None None None None None 7zmo C NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-052 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 3.75 X-RAY DIFFRACTION 0.306 0.283 False True IGHV1 NA NA None None None None None 7cz0 E NA 0 A protein NA thermostable green fluorescent protein (tgp) FLUORESCENT PROTEIN 09/06/20 Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb92) GALAXEA FASCICULARIS; SYNTHETIC CONSTRUCT synthetic construct galaxea fascicularis Cai, H., Yao, H., Li, T., Hutter, C., Tang, Y., Li, Y., Seeger, M., Li, D. 2.77 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 NA NA None None None None None 5f7w D NA 0 B protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group B Lewis b heptasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.81 X-RAY DIFFRACTION 0.208 0.171 False True IGHV1 None None None None None 7ps4 H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-38 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 1.94 X-RAY DIFFRACTION 0.231 0.204 False True IGHV5 IGLV1 Lambda None None None None None 7zfa S T 0 D protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV3 IGKV1 Kappa None None None None None 5u6a B A 0 C | E protein | protein NA | NA immunoglobulin g binding protein a | protein l IMMUNE SYSTEM 12/07/16 CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-PEG3-MEDITOPE HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens staphylococcus aureus | finegoldia magna Williams, J.C., Bzymek, K.P., Pucket, J., Avery, K.A., Ma, Y., Xie, J., Zer, C., Horne, D. 1.736 X-RAY DIFFRACTION 0.188 0.159 False True IGHV3 IGKV1 Kappa None None None None None 6axp B A 0 IMMUNE SYSTEM 09/07/17 Structure of cetuximab with aminoheptanoic acid-linked n-octylarginine meditope variant HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bzymek, K.P., Williams, J.C. 2.484 X-RAY DIFFRACTION 0.228 0.179 False True IGHV2 IGKV5 Kappa 8.5e-06 -6.917510260469774 Unknown TBD 7czq J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P2B-1A10 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4k3d H L 0 IMMUNE SYSTEM 04/10/13 Crystal structure of bovine antibody BLV1H12 with ultralong CDR H3 BOS TAURUS bos taurus bos taurus Ekiert, D.C., Wang, F., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.210 0.182 False True IGHV1 IGLV1 Lambda None None None None None 7ws5 E D 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/28/22 Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Gao, Y., Ji, X., Yang, H. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5a7x R Q 0 I protein hiv-1 yu2 gp120 VIRAL PROTEIN 07/10/15 negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 17.0 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 2qtj D N 2 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4bel D NA 0 A protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 03/11/13 BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 1.85 X-RAY DIFFRACTION 0.22234 0.18130 False True IGHV3 None None None None None 7f62 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/24/21 Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody chAb-25 (Focused refinement of S-RBD and chAb-25 region) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Wu, H.C., Hsu, S.T.D. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 7bxv H L 0 A peptide NA tyr-glu-val-his-his IMMUNE SYSTEM 04/21/20 11A1 antibody-peptide complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Irie, K., Irie, Y., Kita, A., Miki, K. 1.75 X-RAY DIFFRACTION 0.194 0.166 False False IGHV9 IGKV1 Kappa None None None None None 6xw7 D NA 0 B protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5829 and glycochenodeoxycholate (GCDCA) MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 2.15 X-RAY DIFFRACTION 0.215 0.171 False True IGHV1 None None None None None 6mej A B 0 C protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS; HEPACIVIRUS C homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 2.8 X-RAY DIFFRACTION 0.271 0.198 False True IGHV1 IGLV1 Lambda None None None None None 2oz4 H L 0 A protein intercellular adhesion molecule 1 CELL ADHESION 02/23/07 Structural Plasticity in IgSF Domain 4 of ICAM-1 Mediates Cell Surface Dimerization HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chen, X., Kim, T.D., Carman, C.V., Mi, L., Song, G., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.253 0.204 False False IGHV1 IGKV5 Kappa None None None None None 6fuz N NA 0 A protein kinesin light chain 1,kinesin light chain 1,c-jun-amino-terminal kinase-interacting protein 1 MOTOR PROTEIN 02/28/18 Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of JIP1 MUS MUSCULUS; HOMO SAPIENS; LAMA lama mus musculus, homo sapiens Pernigo, S., Dodding, M.P., Steiner, R.A. 2.7 X-RAY DIFFRACTION 0.257 0.233 False True IGHV3 None None None None None 7zfe Z NA 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS lama glama severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV1 NA NA None None None None None 3nab H L 0 IMMUNE SYSTEM 06/01/10 Crystal Structure of fab15 Mut6 HOMO SAPIENS homo sapiens homo sapiens Luo, J. 2.32 X-RAY DIFFRACTION 0.259 0.203 False True IGHV5 IGKV1 Kappa None None None None None 6oro H L 0 G protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 5dd0 H L 0 P peptide oligo peptide IMMUNE SYSTEM 08/24/15 Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Zhang, R., Verkoczy, L., Wiehe, K., Alam, S.M., Nicely, N.I., Santra, S., Bradley, T., Pemble, C., Gao, F., Montefiori, D.C., Bouton-Verville, H., Kelsoe, G., Parks, R., Foulger, A., Tomaras, G., Keple, T.B., Moody, M.A., Liao, H.-X., Haynes, B.F. 2.488 X-RAY DIFFRACTION 0.274 0.227 False True IGHV4 IGKV1 Kappa 8.37e-08 -9.65512996306636 Unknown TBD 6h02 B NA 0 A protein mediator of rna polymerase ii transcription subunit 23 TRANSCRIPTION 07/06/18 Crystal structure of human Mediator subunit MED23 HOMO SAPIENS; LAMA lama homo sapiens Clantin, B., Monte, D., Villeret, V. 2.8 X-RAY DIFFRACTION 0.240 0.199 False True IGHV1 None None None None None 7mrz X Y 0 C protein NA activin receptor type-2b,activin receptor type-1b SIGNALING PROTEIN/IMMUNE SYSTEM 05/10/21 Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Goebel, E.J., Kattamuri, C., Gipson, G.R., Thompson, T.B. 3.0 X-RAY DIFFRACTION 0.327 0.288 False True IGHV4 IGKV4 Kappa None None None None None 6cue q r 0 c protein unknown VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 5aaw F f 0 G protein dengue serotype 4 envelope protein domain 3 07/30/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency DENGUE VIRUS; MUS MUSCULUS mus musculus dengue virus Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R. 3.27 X-RAY DIFFRACTION 0.26258 0.22661 True True unknown unknown unknown 4.320000000000001e-09 -11.411241859183763 SPR TBD 4r7d C D 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 7ezm H h 0 A | B protein | protein NA | NA fusion protein of guanine nucleotide-binding protein g(i)subunit alpha-1 and guanine nucleotide-binding protein g(q) subunit alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/01/21 Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Liu, Q.F., Yang, D.H., Zhuang, Y.W., Croll, T.I., Cai, X.Q., Duan, J., Dai, A.T., Yin, W.C., Ye, C.Y., Zhou, F.L., Wu, B.L., Zhao, Q., Xu, H.E., Wang, M.W., Jiang, Y. 2.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3p9w B NA 0 A protein vascular endothelial growth factor a SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/10 Crystal structure of an engineered human autonomous VH Domain in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens Ma, X., Wiesmann, C. 2.41 X-RAY DIFFRACTION 0.233 0.193 False True IGHV3 1.6e-08 -10.635483235413165 SPR TBD 4xgz M N 0 m peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 6ii9 H L 0 A protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L3A-44 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.5 X-RAY DIFFRACTION 0.234 0.201 False True IGHV4 IGLV1 Lambda 1.94e-08 -10.521320906302677 SPR TBD 4jo2 H L 0 P peptide gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/16/13 Crystal structure of rabbit mAb R56 Fab in complex with V3 crown of HIV-1 Consensus A gp120 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R.M., Kong, X.P. 2.5 X-RAY DIFFRACTION 0.265 0.190 False True IGHV1 IGKV1 Kappa None None None None None 6wtv E F 0 D protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 258259 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.05 X-RAY DIFFRACTION 0.277 0.235 False True IGHV3 IGLV3 Lambda None None None None None 1l7t H L 0 IMMUNE SYSTEM 03/17/02 Crystal Structure Analysis of the anti-testosterone Fab fragment MUS MUSCULUS mus musculus mus musculus Valjakka, J., Hemminki, A., Niemi, S., Soderlund, H., Takkinen, K., Rouvinen, J. 2.1 X-RAY DIFFRACTION 0.275 0.213 False True IGHV5 IGKV1 Kappa None None None None None 7cai E D 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/08/20 SARS-CoV-2 S trimer with two RBDs in the open state and complexed with two H014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 5ihz H L 0 IMMUNE SYSTEM 03/01/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.64 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGLV4 Lambda None None None None None 5wdu U V 0 R protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True unknown unknown unknown None None None None None 5vjo A B 0 E protein lysozyme isoform i (del-i) HYDROLASE/IMMUNE SYSTEM 04/19/17 Complex between HyHEL10 Fab fragment heavy chain mutant I29F and Pekin duck egg lysozyme isoform I (DEL-I) MUS MUSCULUS; ANAS PLATYRHYNCHOS mus musculus mus musculus anas platyrhynchos Langley, D.B., Christ, D. 2.43 X-RAY DIFFRACTION 0.296 0.262 False True IGHV3 IGKV5 Kappa None None None None None 6hd8 A NA 0 TRANSPORT PROTEIN 08/17/18 Crystal structure of the potassium channel MtTMEM175 in complex with a Nanobody-MBP fusion protein LAMA GLAMA; ESCHERICHIA COLI (STRAIN K12); MARIVIRGA TRACTUOSA DSM 4126 lama glama, escherichia coli (strain k12) Brunner, J.D., Jakob, R.P., Schulze, T., Neldner, Y., Moroni, A., Thiel, G., Maier, T., Schenck, S. 2.4 X-RAY DIFFRACTION 0.253 0.209 False True IGHV1 None None None None None 6p9x N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/10/19 CRF1 Receptor Gs GPCR protein complex with CRF1 peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R. 2.91 ELECTRON MICROSCOPY False True IGHV3 None None None None None 5x2q J K 0 C | D protein | protein NA | NA taste receptor, type 1, member 2a | taste receptor, type 1, member 3 SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with glycine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes | oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.6 X-RAY DIFFRACTION 0.230 0.154 False True IGHV1 IGKV3 Kappa None None None None None 6cuf 3 4 0 A protein envelope glycoprotein gp41 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 mus musculus mus musculus human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6y90 H L 0 A protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN 03/06/20 Structure of full-length CD20 in complex with Rituximab Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kumar, A., Reyes, N. 3.69 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 1qnz H L 0 P peptide gp120 IMMUNE SYSTEM 10/26/99 NMR structure of the 0.5b anti-HIV antibody complex with the gp120 V3 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus Tugarinov, V., Zvi, A., Levy, R., Hayek, Y., Matsushita, S., Anglister, J. NOT SOLUTION NMR False True IGHV1 IGKV3 Kappa None None None None None 6aq7 H L 0 A protein major prion protein IMMUNE SYSTEM 08/18/17 Structure of POM6 FAB fragment complexed with mouse PrPc MUS MUSCULUS mus musculus mus musculus mus musculus Baral, P.K., Swayampakula, M., James, M.N.G. 1.83 X-RAY DIFFRACTION 0.230 0.197 False True IGHV1 IGKV3 Kappa None None None None None 4lvo C B 0 A protein subtilisin-like serine protease HYDROLASE/INHIBITOR/IMMUNE SYSTEM 07/26/13 Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex with added CaCl2 PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Withers-Martinez, C., Blackman, M.J. 2.26 X-RAY DIFFRACTION 0.236 0.191 False False IGHV3 IGKV4 Kappa None None None None None 5d9q O o 0 J protein envelope glycoprotein gp120 IMMUNE SYSTEM 08/18/15 Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens human immunodeficiency virus 1 Julien, J.-P., Stanfield, R.L., Ward, A.B., Wilson, I.A. 4.4 X-RAY DIFFRACTION 0.320 0.290 True True unknown unknown unknown None None None None None 4kvn H L 0 A protein hemagglutinin IMMUNE SYSTEM 05/22/13 Crystal structure of Fab 39.29 in complex with Influenza Hemagglutinin A/Perth/16/2009 (H3N2) HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Fong, R., Swem, L.R., Lupardus, P.J. 3.1 X-RAY DIFFRACTION 0.248 0.202 False True IGHV3 IGKV3 Kappa None None None None None 7jhj D d 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/20/20 Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi HOMO SAPIENS; MUS MUSCULUS; EPSTEIN-BARR VIRUS mus musculus homo sapiens | homo sapiens Tsutsumi, N., Qu, Q.H., Skiniotis, G., Garcia, K.C. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6nc2 R W 0 M | F protein | protein NA | NA amc011 v4.2 sosip gp41 | amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B. 5.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6ddm B A 0 C protein mhc class i polypeptide-related sequence a IMMUNE SYSTEM 05/10/18 Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Matsumoto, M.L. 1.3 X-RAY DIFFRACTION 0.205 0.188 False True IGHV1 IGKV4 Kappa 4.2e-10 -12.792176733448072 ITC TBD 7cah E D 0 A protein NA spike glycoprotein VIRAL PROTEIN 06/08/20 The interface of H014 Fab binds to SARS-CoV-2 S HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Rao, Z., wang, Y., Qin, C., Wang, X. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7su1 H L 0 C protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 11/15/21 Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, P.S., Chau, B., Strop, P. 2.53 X-RAY DIFFRACTION 0.251 0.206 False True IGHV3 IGKV3 Kappa None None None None None 2gk0 B A 0 IMMUNE SYSTEM 03/31/06 Structure of Catalytic Elimination Antibody 13G5 from a twinned crystal in space group C2 MUS MUSCULUS mus musculus mus musculus Debler, E.W., Wilson, I.A. 2.45 X-RAY DIFFRACTION unknown unknown False False IGHV2 IGKV1 Kappa None None None None None 4ki5 C D 0 M protein coagulation factor viii IMMUNE SYSTEM 05/01/13 Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Walter, J.D., Meeks, S.L., Healey, J.F., Lollar, P., Spiegel, P.C. 2.47 X-RAY DIFFRACTION 0.238 0.188 False False IGHV9 IGKV4 Kappa None None None None None 6vgr H L 0 B protein dipeptidase 3 HYDROLASE 05/13/20 Crystal Structure of Human Dipeptidase 3 in Complex with Fab of SC-003 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hayashi, K., Longenecker, K.L., Vivona, S. 2.84 X-RAY DIFFRACTION 0.248 0.190 False True IGHV1 IGKV3 Kappa None None None None None 6vca H L 0 B protein NA 5'-nucleotidase, ecto (cd73), isoform cra_a IMMUNE SYSTEM 12/20/19 TB38 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhou, Y.F., Lord, D.M. 3.73 X-RAY DIFFRACTION 0.264 0.224 False True IGHV3 IGLV8 Lambda None None None None None 5dk3 G F 0 IMMUNE SYSTEM 09/02/15 Crystal Structure of Pembrolizumab, a full length IgG4 antibody HOMO SAPIENS homo sapiens homo sapiens Scapin, G., Prosise, W., Reichert, P. 2.28 X-RAY DIFFRACTION 0.224 0.184 False True IGHV1 IGKV3 Kappa None None None None None 5jw5 A B 0 IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 1.9 X-RAY DIFFRACTION 0.217 0.187 False True IGHV6 IGKV1 Kappa None None None None None 7dkj K L 0 I protein NA hemagglutinin VIRAL PROTEIN 11/24/20 Hemagglutinin Influenza A virus (A/Okuda/1957(H2N2) bound with a neutralizing antibody INFLUENZA A VIRUS (A/OKUDA/1957(H2N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/okuda/1957(h2n2)) Kamada, K., Shirouzu, M. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV12 Kappa None None None None None 7fab H L 0 IMMUNOGLOBULIN 11/20/91 CRYSTAL STRUCTURE OF HUMAN IMMUNOGLOBULIN FRAGMENT FAB NEW REFINED AT 2.0 ANGSTROMS RESOLUTION HOMO SAPIENS homo sapiens homo sapiens Saul, F., Poljak, R.J. 2.0 X-RAY DIFFRACTION unknown 0.169 False True IGHV4 IGLV1 Lambda None None None None None 5ovw K NA 0 E protein vitamin b12-binding protein TRANSPORT PROTEIN 08/30/17 Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Mireku, S.A., Sauer, M.M., Glockshuber, R., Locher, K.P. 2.653 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 None None None None None 2kh2 B b 72 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 1fvd D C 0 IMMUNOGLOBULIN 10/20/92 X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Presta, L., Randal, M., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION unknown 0.179 False True IGHV3 IGKV1 Kappa None None None None None 6ey6 J NA 0 B protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 6fyw C NA 0 A | B protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 03/12/18 Structure of B/Brisbane/60/2008 Influenza Hemagglutinin in complex with SD83 INFLUENZA B VIRUS (B/BRISBANE/60/2008); LAMA GLAMA lama glama influenza b virus (b/brisbane/60/2008) | influenza b virus (b/brisbane/60/2008) Laursen, N.S., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.218 0.193 False True IGHV1 None None None None None 6d01 C D 0 I peptide nanp5 IMMUNE SYSTEM 04/09/18 Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Imkeller, K., Wardemann, H., Julien, J.P. 3.2 X-RAY DIFFRACTION 0.227 0.204 False True IGHV3 IGKV1 Kappa 2.86e-07 -8.927113962567878 Unknown TBD 6dwa B A 0 B carbohydrate HD4 4-O-[2-acetamido-2-deoxy-beta-D-glucopyranosyl]-1-O-phosphono-D-ribitol IMMUNE SYSTEM 06/26/18 Structure of the 4497 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fong, R., Lupardus, P.J. 1.922 X-RAY DIFFRACTION 0.235 0.207 False True IGHV3 IGKV4 Kappa None None None None None 6xey F G 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/Immune System 06/14/20 Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rapp, M., Shapiro, L., Ho, D.D. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6nf2 H L 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 4k8r H L 0 B | A protein | protein NA | NA proprotein convertase subtilisin/kexin type 9 | proprotein convertase subtilisin/kexin type 9 IMMUNE SYSTEM 04/18/13 An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Schiele, F., Nar, H. 3.22 X-RAY DIFFRACTION 0.226 0.167 False True IGHV3 IGLV1 Lambda None None None None None 6wqo E F 0 D protein NA reticulocyte binding protein 2b CELL INVASION 04/29/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 283284 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.15 X-RAY DIFFRACTION 0.305 0.254 False True IGHV4 IGKV1 Kappa None None None None None 7web H L 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein with two XGv347 binding to two open state RBDs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3qpq F E 0 IMMUNE SYSTEM 02/14/11 Crystal structure of ANTI-TLR3 antibody C1068 FAB HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Luo, J., Obmolova, G., Teplyakov, A., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.256 0.201 False True IGHV1 IGKV12 Kappa None None None None None 5f72 T t 0 C protein kelch-like ech-associated protein 1 DE NOVO PROTEIN 12/07/15 De novo design and crystallographic validation of antibodies targeting a pre-selected epitope HOMO SAPIENS homo sapiens homo sapiens Liu, X., Taylor, R.D., Griffin, L., Coker, S., Adams, R., Ceska, T., Shi, J., Lawson, A.D.G., Baker, T. 1.85 X-RAY DIFFRACTION 0.265 0.223 True True unknown unknown unknown None None None None None 6x87 I J 0 X protein NA circumsporozoite protein IMMUNE SYSTEM 06/01/20 CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Kucharska, I., Thai, E., Rubinstein, J., Julien, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5gjs H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 07/01/16 Crystal structure of H1 hemagglutinin from A/California/04/2009 in complex with a neutralizing antibody 3E1 HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wang, W., Zhang, T., Ding, J. 2.9 X-RAY DIFFRACTION 0.304 0.251 False True IGHV4 IGKV1 Kappa None None None None None 4n9g A B 0 C peptide epitope scaffold rsv_1isea_ffl_001_c IMMUNE SYSTEM 10/21/13 Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9 MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta synthetic construct Carrico, C.T.D., Strong, R.K. 2.5 X-RAY DIFFRACTION 0.295 0.263 False True IGHV4 IGKV1 Kappa 3.26e-10 -12.942286816628542 Unknown TBD 6meg H L 0 IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 1.41 X-RAY DIFFRACTION 0.200 0.174 False True IGHV1 IGLV1 Lambda None None None None None 3u0t B A 0 F peptide amyloid beta a4 protein IMMUNE SYSTEM 09/29/11 Fab-antibody complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens LaPorte, S.L., Pons, J.P. 2.5 X-RAY DIFFRACTION 0.268 0.219 False True IGHV1 IGKV2D Kappa 3e-10 -12.991531042419238 Unknown TBD 1dfb H L 0 IMMUNOGLOBULIN 03/27/92 STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I HOMO SAPIENS homo sapiens homo sapiens He, X.M., Rueker, F., Casale, E., Carter, D.C. 2.7 X-RAY DIFFRACTION unknown 0.177 False True IGHV3 IGKV1 Kappa None None None None None 6n1v f h 0 A protein pgt122 light chain VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 1igm H L 0 IMMUNOGLOBULIN 07/10/92 THREE DIMENSIONAL STRUCTURE OF AN FV FROM A HUMAN IGM IMMUNOGLOBULIN HOMO SAPIENS homo sapiens homo sapiens Fan, Z.-C., Guddat, L.W., Edmundson, A.B. 2.3 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV1 Kappa None None None None None 6vmj B A 0 Z protein NA complement factor d HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 2.95 X-RAY DIFFRACTION 0.265 0.218 False True IGHV1 IGKV1 Kappa None None None None None 6wo5 H L 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/24/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody 212.1.1 and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 2.619 X-RAY DIFFRACTION 0.250 0.203 False True IGHV1 IGKV1 Kappa None None None None None 6fys F NA 0 VIRAL PROTEIN 03/12/18 Structure of single domain antibody SD83 LAMA GLAMA lama glama Laursen, N.S., Wilson, I.A. 2.0 X-RAY DIFFRACTION 0.231 0.201 False True IGHV1 None None None None None 5zs0 B A 0 C protein envelope glycoprotein b,envelope glycoprotein b VIRAL PROTEIN 04/26/18 Structure of glycoprotein B Domain IV of pseudorabies virus with 7B11 antibody SUID ALPHAHERPESVIRUS 1; MUS MUSCULUS mus musculus mus musculus suid alphaherpesvirus 1 Hu, X.L., Yang, F.L. 3.29 X-RAY DIFFRACTION 0.310 0.241 False False IGHV5 IGKV6 Kappa None None None None None 4jm2 A B 0 E protein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/13/13 Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, L., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.285 0.238 False True IGHV4 IGKV3 Kappa None None None None None 3wih H L 0 A protein roundabout homolog 1 IMMUNE SYSTEM 09/12/13 Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nakayama, T., Mizohata, E., Yamashita, T., Nagatoishi, M., Iwanari, H., Mochizuki, Y., Kado, Y., Yokota, Y., Sato, R., Tsumoto, K., Fujitani, H., Kodama, T., Hamakubo, T., Inoue, T. 1.701 X-RAY DIFFRACTION 0.236 0.189 False False IGHV1 IGKV10 Kappa 1.9e-08 -10.533664762780313 ITC TBD 5t85 H L 0 G protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 09/06/16 Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 and phosphatidylglycerol (06:0 PG) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.373 X-RAY DIFFRACTION 0.250 0.195 False True IGHV3 IGLV3 Lambda None None None None None 5vkk A B 0 IMMUNE SYSTEM 04/21/17 Crystal structure of Fab fragment of anti-CD22 Epratuzumab HOMO SAPIENS, MUS MUSCULUS; HOMO SAPIENS homo sapiens, mus musculus, homo sapiens homo sapiens, mus musculus, homo sapiens Sicard, T., Ereno Orbea, J., Julien, J.-P. 2.014 X-RAY DIFFRACTION 0.237 0.212 False True IGHV1 IGKV8 Kappa None None None None None 1mhh B A 0 IMMUNE SYSTEM 08/20/02 Antibody-antigen complex FINEGOLDIA MAGNA; MUS MUSCULUS mus musculus mus musculus Graille, M., Stura, E.A. 2.1 X-RAY DIFFRACTION 0.247 0.197 False False IGHV9 IGKV8 Kappa 1e-09 -12.27819680469229 Unknown TBD 7kqy E NA 0 NA NA NA NA IMMUNE SYSTEM 11/18/20 Crystal Structure and Characterization of Human Heavy-Chain only Antibodies reveals a novel, stable dimeric structure similar to Monoclonal Antibodies HOMO SAPIENS homo sapiens Bahmanjah, S., Mieczkowski, C., Yu, Y., Baker, J., Raghunathan, G., Tomazela, D., Hsieh, M., Mccoy, M., Strickland, C., Fayadat-Dilman, L. 2.913 X-RAY DIFFRACTION 0.260 0.207 False True IGHV1 NA NA None None None None None 4py7 I J 0 IMMUNE SYSTEM 03/26/14 Crystal Structure of Fab 3.1 HOMO SAPIENS homo sapiens homo sapiens Dreyfus, C. 2.7 X-RAY DIFFRACTION 0.273 0.228 False True IGHV3 IGKV1 Kappa None None None None None 7sl8 B NA 0 A protein NA sodium/glucose cotransporter 1 MEMBRANE PROTEIN 10/23/21 CryoEM structure of SGLT1 at 3.4 A resolution HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Qu, Q., Han, L., Panova, O., Feng, L., Skiniotis, G. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3dgg D C 0 IMMUNE SYSTEM 06/13/08 Crystal structure of FabOX108 HOMO SAPIENS homo sapiens homo sapiens Ren, J., Nettleship, J.E., Owens, R.J., Oxford Protein Production Facility (OPPF) 2.3 X-RAY DIFFRACTION 0.246 0.187 False True IGHV1 IGKV4 Kappa None None None None None 5i75 B C 0 A protein sodium-dependent serotonin transporter MEMBRANE PROTEIN 02/16/16 X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site and Br-citalopram at the allosteric site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Green, E.M., Gouaux, E. 3.49 X-RAY DIFFRACTION 0.286 0.244 False True IGHV1 IGKV6 Kappa None None None None None 4ob5 H L 0 L Hapten TMO TRIMETHYLAMINE OXIDE IMMUNE SYSTEM 01/06/14 Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Jaffe, J.B., Rupert, P.B. 1.7 X-RAY DIFFRACTION 0.207 0.178 False True IGHV1 IGKV3 Kappa None None None None None 7fjo J K 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 08/04/21 Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with three T6 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Zhang, S., Liang, Q. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 4w2q A NA 0 B protein nucleoprotein IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C Complexed with Nucleoprotein C-terminal domain LAMA GLAMA; LAKE VICTORIA MARBURGVIRUS lama glama lake victoria marburgvirus Taylor, A.B., Garza, J.A. 2.7 X-RAY DIFFRACTION 0.274 0.220 False True IGHV1 None None None None None 4ouu B A 0 HYDROLASE 02/19/14 anti-MT1-MMP monoclonal antibody MUS MUSCULUS mus musculus mus musculus Udi, Y., Grossman, M., Solomonov, I., Dym, O., Rozenberg, H., Koziol, A., Cuniasse, P., Dive, V., Arroyo, A.G., Irit, S., Israel Structural Proteomics Center (ISPC) 2.6 X-RAY DIFFRACTION 0.253 0.197 False True IGHV5 IGKV1 Kappa None None None None None 7cw0 O P 0 E | D protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 5.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 7sp9 B NA 0 A protein NA hyaluronan synthase MEMBRANE PROTEIN 11/02/21 Chlorella virus Hyaluronan Synthase in the GlcNAc-primed channel-closed state LAMA GLAMA; PARAMECIUM BURSARIA CHLORELLA VIRUS CZ-2 lama glama paramecium bursaria chlorella virus cz-2 Maloney, F.P., Kuklewicz, J., Zimmer, J. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3lrh NA M 0 N peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 7m7f C D 0 A protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 chimera BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 1mfc H L 0 H carbohydrate GLA polysaccharide IMMUNOGLOBULIN 10/25/93 HIGH RESOLUTION STRUCTURES OF ANTIBODY FAB FRAGMENT COMPLEXED WITH CELL-SURFACE OLIGOSACCHARIDE OF PATHOGENIC SALMONELLA MUS MUSCULUS mus musculus mus musculus mus musculus Zdanov, A., Cygler, M. 2.1 X-RAY DIFFRACTION unknown 0.163 False True IGHV1 IGLV1 Lambda None None None None None 4k3h NA A 0 A Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 6rbb J NA 0 IMMUNE SYSTEM 05/13/20 CRYSTAL STRUCTURE OF the VhH-domain of anti-IL-17A antibody netakimab LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 2.45 X-RAY DIFFRACTION 0.280 0.216 False True IGHV1 None None None None None 6ozc K N 0 F carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN 05/20/20 BG505 SOSIP.664 with 2G12 Fab2 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.79 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 1ob1 E D 0 F protein major merozoite surface protein IMMUNE SYSTEM 01/22/03 Crystal structure of a Fab complex whith Plasmodium falciparum MSP1-19 PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Pizarro, J.C., Chitarra, V., Verger, D., Holm, I., Petres, S., Dartville, S., Nato, F., Longacre, S., Bentley, G.A. 2.9 X-RAY DIFFRACTION 0.288 0.257 False False IGHV9 IGKV4 Kappa 2.00e-10 -12.29 Other 4 12729744 1him M J 0 R peptide influenza hemagglutinin ha1 (strain x47)(residues 100-108) IMMUNOGLOBULIN 07/08/92 STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION MUS MUSCULUS mus musculus mus musculus Schulze-Gahmen, U., Wilson, I.A. 2.9 X-RAY DIFFRACTION unknown 0.200 False True IGHV5 IGKV8 Kappa None None None None None 2fr4 B A 0 M nucleic-acid 5'-d(*cp*tp*gp*cp*cp*tp*tp*cp*ap*g)-3' IMMUNE SYSTEM/DNA 01/18/06 Structure of Fab DNA-1 complexed with a stem-loop DNA ligand MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Tanner, J.J., Ou, Z. 1.95 X-RAY DIFFRACTION 0.256 0.207 False True IGHV1 IGKV12 Kappa 4e-06 -7.3641077518219635 Unknown TBD 6sm2 NA A 0 PROTEIN FIBRIL 08/21/19 Mutant immunoglobulin light chain causing amyloidosis (Pat-1) HOMO SAPIENS homo sapiens Kazman, P., Vielberg, M.-T., Cendales, M.D.P., Hunziger, L., Weber, B., Hegenbart, U., Zacharias, M., Koehler, R., Schoenland, S., Groll, M., Buchner, J. 2.5 X-RAY DIFFRACTION 0.227 0.162 False True IGLV2 Lambda None None None None None 7m30 M N 0 C protein NA envelope protein ul128 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25 HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus Wrapp, D., McLellan, J.S. 3.81 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 2q20 NA B 0 PROTEIN FIBRIL 05/25/07 Structure of the germline Vk1 O18/O8 light chain variable domain homodimer HOMO SAPIENS homo sapiens Thompson, J.R., Ramirez-Alvarado, M., Baden, E.M. 1.3 X-RAY DIFFRACTION 0.148 0.119 False True IGKV1 Kappa None None None None None 5aco I K 0 D protein hiv-1 envelope glycoprotein 08/17/15 Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Ward, A.B. 4.36 ELECTRON MICROSCOPY False True IGHV4 IGLV2 Lambda None None None None None 5uea A B 0 X protein histone chaperone asf1 IMMUNE SYSTEM 12/29/16 Structure of antigen-Fab complex with Histone chaperone ASF1 HOMO SAPIENS; SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C) homo sapiens homo sapiens saccharomyces cerevisiae (strain atcc 204508 /s288c) Bailey, L.J., Kossiakoff, A.A. 1.701 X-RAY DIFFRACTION 0.207 0.154 False True IGHV3 IGKV1 Kappa None None None None None 6e9i A B 0 IMMUNE SYSTEM 08/01/18 The crystal structure of bovine ultralong antibody BOV-4 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 2.5 X-RAY DIFFRACTION 0.243 0.202 False True IGHV1 IGLV1 Lambda None None None None None 5v2a H L 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 03/03/17 Crystal structure of Fab H7.167 in complex with influenza virus hemagglutinin from A/Shanghai/02/2013 (H7N9) INFLUENZA A VIRUS (A/CHICKEN/HENAN/109/2013(H7N9)); INFLUENZA A VIRUS (A/PIGEON/WUXI/0405007G/2013(H7N9)); HOMO homo homo influenza a virus(a/chicken/henan/109/2013(h7n9)) Zhang, H., Zhu, X., Wilson, I.A. 4.656 X-RAY DIFFRACTION 0.334 0.258 False True IGHV3 IGKV4 Kappa None None None None None 6mu3 M K 0 M carbohydrate BMA polysaccharide IMMUNE SYSTEM 10/22/18 Anti-HIV-1 Fab 2G12 + Man7 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wilson, I.A., Calarese, D.A., Stanfield, R.L. 2.327 X-RAY DIFFRACTION 0.235 0.201 False True unknown IGKV1 Kappa 7e-07 -8.39678861981014 Unknown TBD 4z7q E F 0 C protein NA integrin alpha-iib MEMBRANE PROTEIN/IMMUNE SYSTEM 04/07/15 Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lin, F.-Y., Zhu, J., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.236 0.188 False True IGHV14 IGKV14 Kappa None None None None None 6opo I E 0 D protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6cuf M N 0 C protein envelope glycoprotein gp41 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 6sc9 C NA 0 A protein e3 ubiquitin-protein ligase rnf31 LIGASE 07/23/19 dAb3/HOIP-RBR-HOIPIN-8 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Tsai, Y.-C.I., Johansson, H., House, D., Rittinger, K. 2.47 X-RAY DIFFRACTION 0.252 0.210 False True IGHV3 None None None None None 6u52 C NA 0 D protein nucleoprotein IMMUNE SYSTEM 08/26/19 Anti-Sudan ebolavirus Nucleoprotein Single Domain Antibody Sudan B (SB) Complexed with Sudan ebolavirus Nucleoprotein C-terminal Domain 634-738 LAMA GLAMA; SUDAN EBOLAVIRUS (STRAIN BONIFACE-76) lama glama sudan ebolavirus (strain boniface-76) Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 1.9 X-RAY DIFFRACTION 0.243 0.198 False True unknown unknown unknown None None None None None 3q6g I M 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of rhesus mAb 2.5B specific for quaternary neutralizing epitope of HIV-1 gp120 MACACA MULATTA macaca mulatta macaca mulatta Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 1.902 X-RAY DIFFRACTION 0.231 0.191 False False IGHV4 IGLV3 Lambda None None None None None 6bf9 E F 0 B protein insulin-degrading enzyme HYDROLASE/IMMUNE SYSTEM 10/26/17 Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain HOMO SAPIENS; MUS MUSCULUS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. 7.2 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6n1v Q R 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 1xf5 B A 0 P | L peptide | protein NA | NA capsid protein c | protein l IMMUNE SYSTEM 09/14/04 Complex HCV core-Fab 19D9D6-Protein L mutant (H74C, Y64W)in space group P21212 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | finegoldia magna Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 2.6 X-RAY DIFFRACTION 0.240 0.199 False False IGHV9 IGKV8 Kappa None None None None None 2ltq C B 7 A protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 6y0e A NA 0 NA NA NA NA IMMUNE SYSTEM 02/07/20 Nbe LBM LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.5 X-RAY DIFFRACTION 0.180 0.161 False True IGHV1 NA NA None None None None None 6jjp A B 0 C protein programmed cell death protein 1 IMMUNE SYSTEM 02/26/19 Crystal structure of Fab of a PD-1 monoclonal antibody MW11-h317 in complex with PD-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, M., Wang, J., Wang, R., Jiao, S., Wang, S., Zhang, J., Zhang, M. 2.9 X-RAY DIFFRACTION 0.247 0.207 False True IGHV3 IGKV2 Kappa None None None None None 5mu2 A B 0 X peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 4q6i G F 0 I protein t-cell surface glycoprotein cd4 IMMUNE SYSTEM 04/22/14 Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Boyington, J.C., Nabel, G.J., Mascola, J.R. 3.65 X-RAY DIFFRACTION 0.257 0.226 False False IGHV9 IGKV3 Kappa None None None None None 7nvl N NA 0 E protein NA t-complex protein 1 subunit epsilon CHAPERONE 03/15/21 Human TRiC complex in closed state with nanobody bound (Consensus Map) LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Kelly, J.J., Chi, G., Bulawa, C., Paavilainen, V.O., Bountra, C., Huiskonen, J.T., Yue, W., Structural Genomics Consortium (SGC) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1u8i B A 0 C peptide gp41 peptide IMMUNE SYSTEM 08/06/04 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELDKWAN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Bryson, S., Julien, J.-P., Hynes, R.C., Pai, E.F. 2.0 X-RAY DIFFRACTION 0.247 0.233 False False IGHV2 IGKV1 Kappa None None None None None 7lrs D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/17/21 Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody A23-58.1 that targets the receptor-binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Tsybovsky, Y. 3.89 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4rdq K J 0 B protein bestrophin-1 TRANSPORT PROTEIN 09/19/14 Calcium-activated chloride channel bestrophin-1, from chicken, in complex with Fab antibody fragments, chloride and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Dickson, V.K., Pedi, L., Long, S.B. 2.85 X-RAY DIFFRACTION 0.234 0.217 False False IGHV1 IGKV12 Kappa 1.5000000000000002e-08 -10.67372125591851 Unknown TBD 2bx5 NA N 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 4hha B A 0 P peptide glycoprotein b IMMUNE SYSTEM 10/09/12 Anti-Human Cytomegalovirus (HCMV) Fab KE5 with epitope peptide AD-2S1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human herpesvirus 5 Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Pfoh, R., Schrader, J.W., Pai, E.F. 1.6 X-RAY DIFFRACTION 0.226 0.213 False False IGHV3 IGKV3 Kappa None None None None None 6wgb C D 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Crystal structure of the fab portion of dupilumab HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.99 X-RAY DIFFRACTION 0.299 0.243 False True IGHV3 IGKV2 Kappa None None None None None 1xct B A 0 P | L peptide | protein NA | NA capsid protein c | protein l IMMUNE SYSTEM 09/03/04 Complex HCV core-Fab 19D9D6-Protein L mutant (D55A, L57H, Y64W) in space group P21212 FINEGOLDIA MAGNA; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus | finegoldia magna Menez, R., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 3.05 X-RAY DIFFRACTION 0.329 0.193 False False IGHV9 IGKV8 Kappa None None None None None 2dqf B A 0 C protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/25/06 Crystal structure of hyhel-10 FV mutant (y33ay53a) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 2.5 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV5 Kappa None None None None None 3ejy E F 0 B protein h(+)/cl(-) exchange transporter clca IMMUNE SYSTEM/PROTON TRANSPORT 09/18/08 Structure of E203H mutant of E.coli Cl-/H+ antiporter, CLC-ec1 ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 3.2 X-RAY DIFFRACTION 0.279 0.244 False False IGHV4 IGKV4 Kappa None None None None None 7chc A B 0 R protein NA spike glycoprotein PROTEIN BINDING/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab and BD-368-2 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J.Y. 2.71 X-RAY DIFFRACTION 0.286 0.212 False True IGHV3 IGKV2 Kappa None None None None None 1wt5 A C 0 IMMUNE SYSTEM 11/16/04 The Crystal Structure Of A Humanized Antibody Fv 528 HOMO SAPIENS homo sapiens homo sapiens Makabe, K., Tsumoto, K., Asano, R., Kondo, H., Kumagai, I. 2.1 X-RAY DIFFRACTION 0.301 0.273 False True IGHV1 IGKV2 Kappa None None None None None 7cw0 Q R 0 H | G protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 5.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 4nhg H L 0 IMMUNE SYSTEM 11/05/13 Crystal Structure of 2G12 IgG Dimer HOMO SAPIENS homo sapiens homo sapiens Wu, Y., West, Jr., A.P., Kim, H.J., Thornton, M.E., Ward, A.B., Bjorkman, P.J. 8.001 X-RAY DIFFRACTION 0.369 0.359 False True unknown IGKV1 Kappa None None None None None 1ahw B A 0 C protein tissue factor COMPLEX (IMMUNOGLOBULIN/TISSUE FACTOR) 04/10/97 A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.285 0.217 False False IGHV14 IGKV14 Kappa None None None None None 7k4n H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/15/20 SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Tortorici, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5f9w H L 0 G protein clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 12/10/15 Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235 in complex with HIV-1 clade A/E 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chen, L., Zhou, T., Kwong, P.D. 2.8911 X-RAY DIFFRACTION 0.232 0.180 False True IGHV1 IGKV3 Kappa None None None None None 3chn B M 9 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7zfd H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-25 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.39 X-RAY DIFFRACTION 0.338 0.286 False True IGHV3 IGKV1 Kappa None None None None None 7my2 A NA 0 B protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/20/21 CryoEM structure of neutralizing nanobody Nb30 in complex with SARS-CoV2 spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Xu, K., Kwong, P.D. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7mwx E F 0 G protein NA core protein precursor ee2 VIRAL PROTEIN/IMMUNE SYSTEM 05/17/21 Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 with tamarin CD81 HEPACIVIRUS C; MUS MUSCULUS; SAGUINUS OEDIPUS mus musculus mus musculus hepacivirus c Kumar, A., Hossain, R.A., Yost, S.A., Bu, W., Wang, Y., Dearborn, A.D., Grakoui, A., Cohen, J.I., Marcotrigiano, J. 3.32 X-RAY DIFFRACTION 0.283 0.239 False True IGHV14 IGKV8 Kappa None None None None None 6b5s H L 0 A peptide pfcsp peptide 25asp-pro-asn IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 25 with human antibody CIS42 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 1.983 X-RAY DIFFRACTION 0.204 0.168 False True IGHV7 IGLV2 Lambda None None None None None 7e5s E H 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 2d7t H L 0 IMMUNE SYSTEM 11/29/05 Crystal structure of human anti polyhydroxybutyrate antibody Fv HOMO SAPIENS homo sapiens homo sapiens Watanabe, H. 1.7 X-RAY DIFFRACTION 0.214 0.190 False True IGHV1 IGKV1 Kappa None None None None None 6bzw E F 0 K peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody AP33 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.2 X-RAY DIFFRACTION 0.231 0.192 False True IGHV3 IGKV3 Kappa None None None None None 7niu E D 0 A protein NA isoform 2 of phosphatidylcholine translocator abcb4 PROTEIN TRANSPORT 02/14/21 Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (apo-inward-open conformation) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nosol, K., Locher, K.P. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4ma3 H L 0 IMMUNE SYSTEM 08/15/13 Crystal structure of anti-hinge rabbit antibody C2095 ORYCTOLAGUS CUNICULUS, HOMO SAPIENS oryctolagus cuniculus, homo sapiens oryctolagus cuniculus, homo sapiens Malia, T., Teplyakov, A., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 IGKV1 Kappa None None None None None 6c6y H L 0 R protein spike glycoprotein IMMUNE SYSTEM 01/19/18 Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain MACACA MULATTA; BETACORONAVIRUS ENGLAND 1 macaca mulatta macaca mulatta betacoronavirus england 1 Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D. 3.32 X-RAY DIFFRACTION 0.267 0.232 False True IGHV4 IGKV1 Kappa None None None None None 6rak C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing occluded conformation THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 3.3 ELECTRON MICROSCOPY False True IGHV1 None None None None None 3rkd H L 0 A protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 04/18/11 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody HEPATITIS E VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis e virus Tang, X.H., Sivaraman, J. 1.9 X-RAY DIFFRACTION 0.217 0.189 False False IGHV8 IGKV12 Kappa 5.89e-09 -11.22 SPR 21642534 4ygv F L 0 IMMUNE SYSTEM 02/26/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens Schiele, F., Nar, H. 1.76 X-RAY DIFFRACTION 0.198 0.178 False True IGHV1 IGKV1 Kappa None None None None None 7now C NA 0 D protein NA nuclear pore complex protein nup96 NUCLEAR PROTEIN 02/26/21 Complex of Nucleoporin-98 and nanobody MS98-27 solved at 1.85A resolution VICUGNA PACOS; XENOPUS TROPICALIS vicugna pacos xenopus tropicalis Sola-Colom, M., Trakhanov, S., Goerlich, D. 1.85 X-RAY DIFFRACTION 0.209 0.184 False True IGHV1 NA NA None None None None None 7zrc F G 0 B protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/04/22 OMI-38 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7e5o H L 0 A protein NA spike protein s1 VIRAL PROTEIN 02/19/21 Crystal structure of SARS-CoV-2 RBD in complex with antibody NT-193 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kita, S., Onodera, T., Adachi, Y., Moriayma, S., Nomura, T., Tadokoro, T., Anraku, Y., Yumoto, K., Tian, C., Fukuhara, H., Suzuki, T., Tonouchi, K., Sasaki, J., Sun, L., Hashiguchi, T., Takahashi, Y., Maenaka, K. 2.8 X-RAY DIFFRACTION 0.256 0.226 False True IGHV4 IGKV1 Kappa None None None None None 6l98 NA B 0 NA NA NA NA IMMUNE SYSTEM 11/08/19 Crystalline cast nephropathy-causing Bence-Jones protein AK: An entire immunoglobulin lambda light chain dimer HOMO SAPIENS homo sapiens Nakagaki, T., Noguchi, K., Yohda, M., Odaka, M., Wakui, H., Matsumura, H. 1.77 X-RAY DIFFRACTION 0.265 0.229 False True NA IGLV3 Lambda None None None None None 5umn C D 0 B protein hemagglutinin IMMUNE SYSTEM 01/27/17 Crystal structure of C05 VPGSGW mutant bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Wu, N.C., Wilson, I.A. 1.97 X-RAY DIFFRACTION 0.208 0.181 False True IGHV3 IGKV1 Kappa None None None None None 1dsf H L 0 IMMUNOGLOBULIN 05/04/97 THE CRYSTAL STRUCTURE OF THE DISULFIDE-STABILIZED FV FRAGMENT OF ANTICANCER ANTIBODY B1: CONFORMATIONAL INFLUENCE OF AN ENGINEERED DISULFIDE BOND MUS MUSCULUS mus musculus mus musculus Almog, O., Gilliland, G.L. 2.0 X-RAY DIFFRACTION unknown 0.182 False True IGHV5 IGKV1 Kappa None None None None None 7f9z N NA 0 A | B protein | protein NA | NA engineered g-alpha-q | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 07/05/21 GHRP-6-bound ghrelin receptor in complex with Gq HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Wang, Y., Zhuang, Y., Xu, P., Xu, H.E., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5yd3 C c 0 D peptide epitope peptide IMMUNE SYSTEM 09/11/17 Crystal structure of the scFv antibody 4B08 with epitope peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K. 1.35 X-RAY DIFFRACTION 0.184 0.136 True True unknown unknown unknown None None None None None 6xxn B NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 7bu8 G I 0 B protein genome polyprotein VIRUS 05/13/20 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 6.5 HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 3.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7mjh F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.66 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1nmb H L 0 N protein n9 neuraminidase COMPLEX (HYDROLASE/IMMUNOGLOBULIN) 01/17/95 THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Malby, R.L., Tulip, W.R., Colman, P.M. 2.2 X-RAY DIFFRACTION unknown 0.210 False False IGHV1 IGKV10 Kappa None None None None None 2wzp L NA 0 I protein putative receptor binding protein VIRAL PROTEIN 12/01/09 Structures of Lactococcal Phage p2 Baseplate Shed Light on a Novel Mechanism of Host Attachment and Activation in Siphoviridae LACTOCOCCUS PHAGE P2; LAMA GLAMA lama glama lactococcus phage p2 Sciara, G., Bebeacua, C., Bron, P., Tremblay, D., Ortiz-Lombardia, M., Lichiere, J., van Heel, M., Campanacci, V., Moineau, S., Cambillau, C. 2.6 X-RAY DIFFRACTION 0.2078 0.1789 False True IGHV1 None None None None None 3f5w A B 0 C protein voltage-gated potassium channel membrane protein/metal transport 11/04/08 KcsA Potassium channel in the open-inactivated state with 32 A opening at T112 MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 3.3 X-RAY DIFFRACTION 0.265 0.259 False False IGHV1 IGKV5 Kappa None None None None None 6p3r A B 0 L protein hemagglutinin VIRAL PROTEIN 05/27/20 crystal structure of human Fab H5.31 in complex with influenza A H5N1 Vietnam hemagglutinin head domain HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/VIETNAM/32/2004(H5N1)) homo sapiens homo sapiens influenza a virus(a/chicken/vietnam/32/2004(h5n1)) Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.226 0.192 False True IGHV3 IGKV1 Kappa None None None None None 6xr0 H L 0 M protein NA melanotransferrin METAL TRANSPORT 07/10/20 Crystal Structure of Human Melanotransferrin in complex with SC57.32 Fab HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Hayashi, K., Longenecker, K.L., Vivona, S. 3.064 X-RAY DIFFRACTION 0.225 0.202 False False IGHV1 IGKV10 Kappa None None None None None 7enf P O 0 B protein NA spike glycoprotein VIRAL PROTEIN 04/16/21 Cryo-EM structure of the SARS-CoV-2 S-6P in complex with Fab30 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.F., Zhu, Y.Q. 2.76 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV4 Kappa None None None None None 7cgw H L 0 P protein NA programmed cell death protein 1 ANTITUMOR PROTEIN 07/02/20 Complex structure of PD-1 and tislelizumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hong, Y., Feng, Y.C., Liu, Y. 3.2 X-RAY DIFFRACTION 0.254 0.218 False True IGHV4 IGKV4 Kappa None None None None None 7v9m N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 08/26/21 Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex HOMO SAPIENS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Cong, Z.T., Zhou, F.L., Zhang, C., Zou, X.Y., Zhang, H.B., Wang, Y.Z., Zhou, Q.T., Cai, X.Q., Liu, Q.F., Li, J., Shao, L.J., Mao, C.Y., Wang, X., Wu, J.H., Xia, T., Zhao, L.H., Jiang, H.L., Zhang, Y., Xu, H.E., Chen, X., Yang, D.H., Wang, M.W. 3.29 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7mf8 H L 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100fA Fab in space group P6422 HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.238 0.207 False True IGHV3 IGLV3 Lambda None None None None None 3cfe H L 0 IMMUNE SYSTEM 03/03/08 Crystal structure of purple-fluorescent antibody EP2-25C10 MUS MUSCULUS mus musculus mus musculus Debler, E.W., Heine, A., Wilson, I.A. 2.99 X-RAY DIFFRACTION 0.255 0.211 False False IGHV3 IGKV10 Kappa None None None None None 5th2 B A 0 IMMUNE SYSTEM 09/28/16 Cetuximab Fab in complex with L5Q meditope variant MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 1.84 X-RAY DIFFRACTION 0.184 0.161 False True IGHV2 IGKV5 Kappa 2.9999999999999997e-05 -6.170310595367968 Unknown TBD 6jfh H L 0 E protein zikv structural e protein ANTIVIRAL PROTEIN 04/10/19 The asymmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q. 20 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 5cba C D 0 F protein c-x-c motif chemokine 13 IMMUNE SYSTEM 06/30/15 3B4 in complex with CXCL13 - 3B4-CXCL13 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Tu, C., Bard, J., Mosyak, L. 2.5 X-RAY DIFFRACTION 0.237 0.197 True True IGHV1 IGLV2 Lambda None None None None None 4am0 A B 0 S protein envelope protein, VIRAL PROTEIN 03/06/12 Structure of Dengue virus strain 4 DIII in complex with Fab 2H12 DENGUE VIRUS; HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus dengue virus Midgley, C.M., Flanagan, A., Mongkolsapaya, J., Grimes, J.M., Screaton, G.R. 3.02 X-RAY DIFFRACTION 0.2522 0.1960 False False IGHV1 IGKV6 Kappa 4.2e-10 -12.792176733448072 ELISA TBD 6oao J j 0 I protein duffy binding surface protein region ii CELL INVASION 03/18/19 Structure of DBP in complex with human neutralizing antibody 092096 PLASMODIUM VIVAX; HOMO SAPIENS homo sapiens plasmodium vivax Urusova, D., Tolia, N.H. 3.497 X-RAY DIFFRACTION 0.279 0.238 True True unknown unknown unknown None None None None None 6fg2 D E 0 IMMUNE SYSTEM 01/09/18 CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA84. HOMO SAPIENS homo sapiens homo sapiens Bertrand, T., Pouzieux, S. 2.788 X-RAY DIFFRACTION 0.263 0.238 False True IGHV3 IGLV3 Lambda None None None None None 7dv4 B NA 0 A protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 01/12/21 Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 HOMO SAPIENS homo sapiens homo sapiens Li, H., Gan, X., He, Y. 2.38 X-RAY DIFFRACTION 0.258 0.221 False True IGHV3 NA NA None None None None None 7xjl E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/18/22 Cryo-EM structure of the spexin-bound GALR2-miniGq complex Homo sapiens homo sapiens homo sapiens | homo sapiens Jiang, W., Zheng, S. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6pyd H L 0 H Hapten P4S (3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide IMMUNE SYSTEM 07/29/19 Structure of 3E9 antibody Fab bound to marinobufagenin MUS MUSCULUS mus musculus mus musculus mus musculus Franklin, M.C., Macdonald, L.E., McWhirter, J., Murphy, A.J. 2.0 X-RAY DIFFRACTION 0.276 0.229 False True IGHV3 IGKV1 Kappa None None None None None 6x40 K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 2.86 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 3g5x D C 0 IMMUNE SYSTEM 02/05/09 Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR MUS MUSCULUS mus musculus mus musculus Garrett, T.P.J., Burgess, A.W. 2.3 X-RAY DIFFRACTION 0.289 0.225 False True IGHV3 IGKV14 Kappa None None None None None 4r0l A B 0 C protein t-cell costimulatory molecule cd28 IMMUNE SYSTEM 07/31/14 Anti-canine CD28 antibody, 1C6, bound canine CD28 CANIS LUPUS FAMILIARIS; MUS MUSCULUS mus musculus canis lupus familiaris mus musculus Gewe, M.M., Strong, R.K. 3.3 X-RAY DIFFRACTION 0.293 0.256 False True IGHV9 IGKV2 Kappa None None None None None 2fjf F E 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 5te7 H L 0 G protein hiv-1 gp120 core IMMUNE SYSTEM 09/20/16 Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in complex with HIV-1 Clade C strain DU172.17 core gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.15 X-RAY DIFFRACTION 0.228 0.190 False True unknown unknown unknown 2.8100000000000004e-09 -11.666051859880756 SPR TBD 7phv E F 0 D protein NA cysteine-rich protective antigen IMMUNE SYSTEM 08/18/21 PfCyRPA bound to monoclonal antibody Cy.007 Fab fragment PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.091 X-RAY DIFFRACTION 0.332 0.287 False True unknown unknown unknown None None None None None 3qo0 B A 0 C peptide peptide from tubulin beta chain IMMUNE SYSTEM 02/09/11 Monoclinic form of IgG1 Fab fragment (in complex with antigenic peptide) sharing same Fv as IgA HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Trajtenberg, F., Correa-Bove, A., Buschiazzo, A. 2.3 X-RAY DIFFRACTION 0.221 0.169 False False IGHV3 IGKV2 Kappa None None None None None 5m2i G NA 0 B protein tumor necrosis factor CYTOKINE 10/13/16 Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.15 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 5.400000000000001e-10 -12.643277036143104 SPR TBD 5jhl H L 0 A protein envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 04/21/16 Crystal structure of zika virus envelope protein in complex with a flavivirus broadly-protective antibody MUS; ZIKA VIRUS mus mus zika virus Dai, L., Shi, Y., Qi, J., Gao, G.F. 3.0 X-RAY DIFFRACTION 0.269 0.228 False True IGHV1 IGKV6 Kappa 2.7e-09 -11.689711339052632 SPR TBD 4k3h NA G 0 G Hapten 1OM 4-{bis[4-(dimethylamino)phenyl]methyl}phenol immune system/inhibitor 04/10/13 Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green HOMO SAPIENS homo sapiens homo sapiens Stanfield, R.L., Szent-Gyorgyi, C., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.225 0.194 False True IGLV7 Lambda 1.4e-07 -9.350354316900614 Unknown TBD 4tnw H L 0 A protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False IGHV1 IGLV1 Lambda None None None None None 1mcp H L 0 IMMUNOGLOBULIN 07/09/84 PHOSPHOCHOLINE BINDING IMMUNOGLOBULIN FAB MC/PC603. AN X-RAY DIFFRACTION STUDY AT 2.7 ANGSTROMS MUS MUSCULUS mus musculus mus musculus Satow, Y., Cohen, G.H., Padlan, E.A., Davies, D.R. 2.7 X-RAY DIFFRACTION unknown 0.225 False True IGHV7 IGKV8 Kappa None None None None None 6lr7 B NA 0 A protein green fluorescient protein uv FLUORESCENT PROTEIN 01/15/20 Crystal structure of GFPuv complexed with the nanobody LaG16 at 1.67 Angstron resolution AEQUOREA VICTORIA; CAMELUS BACTRIANUS camelus bactrianus aequorea victoria Zhang, Z.Y., Ding, Y., Hattori, M. 1.67 X-RAY DIFFRACTION 0.226 0.185 False True IGHV1 None None None None None 5v7j H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 03/20/17 Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Four Glycans (N197, N276, N362, and N462) removed in Complex with Neutralizing Antibodies 3H+109L and 35O22. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Stewart-Jones, G.B.E., Zhou, T., Kwong, P.D. 2.907 X-RAY DIFFRACTION 0.339 0.316 False True IGHV4 unknown unknown None None None None None 7t3d J M 0 E protein NA hemagglutinin ha1 chain Viral Protein/IMMUNE SYSTEM 12/07/21 CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA INFLUENZA A VIRUS (A/CALIFORNIA/04/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009(h1n1)) Han, J., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7u0d M N 0 B protein NA surface glycoprotein Vral Protein/IMMUNE SYSTEM 02/17/22 Local refinement of cryo-EM structure of the interface of the Omicron RBD in complex with antibodies B-182.1 and A19-46.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., kwong, P.D. 4.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV8 Lambda None None None None None 3ulu F E 0 A protein toll-like receptor 3 IMMUNE SYSTEM 11/11/11 Structure of quaternary complex of human TLR3ecd with three Fabs (Form1) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 3.52 X-RAY DIFFRACTION 0.309 0.268 False True IGHV1 IGKV12 Kappa None None None None None 7wue E F 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/22 Crystal structure of SARS-CoV-2 Receptor Binding Domain in complex with the monoclonal antibody m31A7 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Mohapatra, A. 3.2 X-RAY DIFFRACTION 0.295 0.228 False True IGHV1 IGKV8 Kappa None None None None None 5ggu H L 0 IMMUNE SYSTEM 06/16/16 Crystal structure of tremelimumab Fab homo sapiens homo sapiens Heo, Y.S. 2.292 X-RAY DIFFRACTION 0.243 0.185 False True IGHV3 IGKV1 Kappa None None None None None 5a8h D C 0 A protein NA hiv-1 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 07/15/15 cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 23.0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7f4d N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/18/21 Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35 HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ma, S., Chen, Y., Dai, A., Yin, W., Guo, J., Yang, D., Zhou, F., Jiang, Y., Wang, M.-W., Xu, H.E. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3kym D C 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 3c6s D C 0 D carbohydrate RAM polysaccharide IMMUNE SYSTEM 02/05/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag pentadecasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.251 0.191 False False IGHV6 IGKV2 Kappa None None None None None 6vmk V U 0 X protein NA complement factor d HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 5vag C B 0 A protein hemagglutinin IMMUNE SYSTEM 03/26/17 Crystal structure of H7-specific antibody m826 in complex with the HA1 domain of hemagglutinin from H7N9 influenza virus INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Song, H., Ying, T., Ji, X. 1.9 X-RAY DIFFRACTION 0.227 0.191 False True IGHV1 IGKV1 Kappa 9.400000000000001e-09 -10.950612882178413 SPR TBD 6u8k D E 0 B nucleic-acid jiiiabc rna (68-mer) RNA/Immune System 09/05/19 Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV3 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepacivirus c Koirala, D., Lewicka, A., Koldobskaya, Y., Huang, H., Piccirilli, J.A. 2.75 X-RAY DIFFRACTION 0.222 0.186 False True IGHV3 IGKV1 Kappa None None None None None 2gfb B A 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 7lue I M 0 B protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 02/22/21 Prefusion RSV F glycoprotein bound by neutralizing site V-directed antibody ADI-14442 RESPIRATORY SYNCYTIAL VIRUS A2; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus a2 Gilman, M.S.A., McLellan, J.S. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 2znw A a 0 Y protein NA lysozyme c IMMUNE SYSTEM/HYDROLASE 05/02/08 Crystal Structure of ScFv10 in Complex with Hen Egg Lysozyme MUS MUSCULUS; SYNTHETIC CONSTRUCT; GALLUS GALLUS mus musculus, synthetic construct gallus gallus DeSantis, M.E., Acchione, M., Li, M., Walter, R.L., Wlodawer, A., Smith-Gill, S. 2.71 X-RAY DIFFRACTION 0.250 0.193 True True unknown unknown unknown None None None None None 2b0s H L 0 P peptide mn peptide of exterior membrane glycoprotein gp120 IMMMUNE SYSTEM 09/14/05 Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with MN peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Stanfield, R.L., Gorny, M.K., Zolla-Pazner, S., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.267 0.217 False False IGHV5 IGLV1 Lambda None None None None None 3t3m H L 0 A | D protein | protein NA | NA integrin alpha-iib | integrin beta-3 CELL ADHESION 07/25/11 A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Zhu, J., Zhu, J., Springer, T.A. 2.6 X-RAY DIFFRACTION 0.222 0.179 False True IGHV14 IGKV14 Kappa None None None None None 5u7m H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/Immune system 12/12/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer bound to small molecule HIV-1 entry inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 A. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Lai, Y.-T., Kwong, P.D. 3.025 X-RAY DIFFRACTION 0.289 0.245 False True IGHV4 IGLV3 Lambda 1.8000000000000002e-07 -9.201454619595646 Unknown TBD 5o05 D NA 0 A protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 norovirus protruding domain in complex with Nanobody Nano-42 VICUGNA PACOS; NORWALK VIRUS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, G.S. 2.0 X-RAY DIFFRACTION 0.222 0.180 False True IGHV1 8.100000000000001e-10 -12.403045576779583 ITC TBD 6xlq H I 0 G protein NA butyrophilin subfamily 3 member a1 IMMUNE SYSTEM 06/29/20 Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the CTX-2026 Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Payne, K.K., Mine, J.A., Biswas, S., Chaurio, R.A., Perales-Puchalt, A., Anadon, C.M., Costich, T.L., Harro, C.M., Walrath, J., Ming, Q., Tcyganov, E., Buras, A.L., Rigolizzo, K.E., Mandal, G., Lajoie, J., Ophir, M., Tchou, J., Marchion, D., Luca, V.C., Bobrowicz, P., McLaughlin, B., Eskiocak, U., Schmidt, M., Cubillos-Ruiz, J.R., Rodriguez, P.C., Gabrilovich, D.I., Conejo-Garcia, J.R. 3.0 X-RAY DIFFRACTION 0.296 0.246 False True IGHV1 IGKV1 Kappa None None None None None 6s8i H L 0 A protein enveloped glycoprotein 1 VIRAL PROTEIN 07/10/19 Structure of ZEBOV GP in complex with 3T0265 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 2.99 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 7v2a G F 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/07/21 SARS-CoV-2 Spike trimer in complex with XG014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, K., Wang, X., Pan, L. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 6idl M N 0 F protein premembrane protein VIRUS 09/10/18 Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 5.0 (Class II particle) DENGUE VIRUS 3; HOMO SAPIENS homo sapiens homo sapiens dengue virus 3 Wirawan, M., Fibriansah, G., Ng, T.S., Zhang, Q., Kostyuchenko, V.A., Shi, J., Lok, S.M. 25 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 1ncc H L 0 N protein influenza a subtype n9 neuraminidase HYDROLASE(O-GLYCOSYL) 01/21/92 CRYSTAL STRUCTURES OF TWO MUTANT NEURAMINIDASE-ANTIBODY COMPLEXES WITH AMINO ACID SUBSTITUTIONS IN THE INTERFACE INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Tulip, W.R., Varghese, J.N., Colman, P.M. 2.5 X-RAY DIFFRACTION unknown 0.212 False False IGHV9 IGKV6 Kappa None None None None None 7ryv E F 0 NA NA NA NA IMMUNE SYSTEM 08/26/21 Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques MACACA MULATTA macaca mulatta macaca mulatta Yang, Z., Bjorkman, P.J. 2.5 X-RAY DIFFRACTION 0.254 0.216 False True IGHV1 IGLV1 Lambda None None None None None 5sv3 A NA 0 B protein ricin TOXIN 08/04/16 RTA1-33/44-198 (RVEC) bound to Single Domain Antibody A3C8 LAMA GLAMA; RICINUS COMMUNIS lama glama ricinus communis Compton, J.R., Legler, P.M. 2.73 X-RAY DIFFRACTION 0.267 0.226 False True IGHV1 6.27e-10 -12.554773363845591 SPR TBD 6b5m H L 0 A peptide pfcsp peptide 21asp-pro-asn IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 21 with human protective antibody CIS43 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 1.79 X-RAY DIFFRACTION 0.235 0.207 False True IGHV1 IGKV4 Kappa None None None None None 3bz4 F E 0 F carbohydrate RAM polysaccharide IMMUNE SYSTEM 01/17/08 Crystal structure of Fab F22-4 in complex with a Shigella flexneri 2a O-Ag decasaccharide MUS MUSCULUS mus musculus mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 1.8 X-RAY DIFFRACTION 0.230 0.176 False False IGHV6 IGKV2 Kappa None None None None None 5cp7 D E 0 IMMUNE SYSTEM 07/21/15 Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides MUS MUSCULUS mus musculus mus musculus Wang, Z., Shen, J., Li, C., Li, Y., Wen, K., Yu, X., Zhang, X. 3.01 X-RAY DIFFRACTION 0.302 0.260 False False IGHV3 IGKV1 Kappa None None None None None 3h3b c C 0 B protein receptor tyrosine-protein kinase erbb-2 IMMUNE SYSTEM 04/16/09 Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Zhou, H., Liu, Y., Niu, L., Zhu, J., Teng, M. 2.45 X-RAY DIFFRACTION 0.255 0.201 True True unknown unknown unknown None None None None None 6o3u H L 0 H Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 02/27/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with 06:0 PA HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Wilson, I.A. 3.105 X-RAY DIFFRACTION 0.228 0.186 False True IGHV1 IGKV3 Kappa None None None None None 2kqm NA A 17 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7nx2 B A 0 NA NA NA NA PROTEIN BINDING 03/17/21 Unbound antigen-binding fragment (FAb) 324 MUS MUSCULUS mus musculus mus musculus De Munck, S., Savvides, S.N. 1.47 X-RAY DIFFRACTION 0.206 0.168 False True IGHV1 IGKV3 Kappa None None None None None 6fg2 I M 0 IMMUNE SYSTEM 01/09/18 CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA84. HOMO SAPIENS homo sapiens homo sapiens Bertrand, T., Pouzieux, S. 2.788 X-RAY DIFFRACTION 0.263 0.238 False True IGHV1 IGKV19 Kappa None None None None None 7aqz C NA 0 B protein NA variant surface glycoprotein mitat 1.2 MEMBRANE PROTEIN 10/23/20 Co-Crystal Structure of Variant Surface Glycoprotein VSG2 in complex with Nanobody VSG2(NB14) LAMA GLAMA; TRYPANOSOMA BRUCEI BRUCEI lama glama trypanosoma brucei brucei Stebbins, C.E., Hempelmann, A., VanStraaten, M. 1.3 X-RAY DIFFRACTION 0.172 0.151 False True IGHV1 NA NA None None None None None 4dka A NA 0 D | C protein | protein NA | NA rna-editing complex protein mp81 | rna-editing complex protein mp81 RNA BINDING PROTEIN/IMMUNE SYSTEM 02/03/12 Structure of Editosome protein LAMA GLAMA; TRYPANOSOMA BRUCEI lama trypanosoma brucei | trypanosoma brucei Park, Y.-J., Hol, W. 1.97 X-RAY DIFFRACTION 0.229 0.187 False True IGHV1 None None None None None 7tp4 H L 0 Z protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 01/24/22 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K398.22 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MACACA MULATTA macaca mulatta macaca mulatta severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 1.95 X-RAY DIFFRACTION 0.231 0.205 False True IGHV3 IGLV2 Lambda None None None None None 5bk5 D C 0 IMMUNE SYSTEM 09/12/17 Crystal structure of the anti-circumsporozoite protein 663 germline antibody HOMO SAPIENS homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 3.0 X-RAY DIFFRACTION 0.314 0.257 False True IGHV3 IGKV2 Kappa None None None None None 5tkj D E 0 F peptide hiv-1 fusion peptide residue 512-519 IMMUNE SYSTEM 10/06/16 Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.118 X-RAY DIFFRACTION 0.241 0.198 False True IGHV1 IGKV1 Kappa 7.150000000000001e-09 -11.112714836617695 Unknown TBD 7cvz O P 0 E | D protein | protein NA | NA e2 glycoprotein | e1 glycoprotein VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263 CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 5cil H L 0 P peptide peptide from the mper region of the env protein of hiv-1 IMMUNE SYSTEM 07/13/15 Crystal Structure of non-neutralizing version of 4E10 (WDWD) with epitope bound HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caaveiro, J.M.M., Rujas, E., Nieva, J.L., Tsumoto, K. 1.81 X-RAY DIFFRACTION 0.188 0.163 False True IGHV1 IGKV3 Kappa 4.1e-08 -10.077965960666114 Unknown TBD 5mud NA A 0 IMMUNE SYSTEM 01/13/17 Crystal structure of an amyloidogenic light chain dimer H6 HOMO SAPIENS homo sapiens Oberti, L., Bacarizo, J., Maritan, M., Rognoni, P., Bolognesi, M., Ricagno, S. 2.34 X-RAY DIFFRACTION 0.249 0.205 False True IGLV1 Lambda None None None None None 7qji G NA 0 E protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.1 X-RAY DIFFRACTION 0.316 0.267 False True IGHV1 NA NA None None None None None 5kqv C D 0 E protein insulin receptor,insulin receptor Hormone/Hormone Receptor/Immune System 07/06/16 Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) HOMO SAPIENS; BOS TAURUS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lawrence, M.C., Smith, B.J., Croll, T.I. 4.4 X-RAY DIFFRACTION 0.266 0.229 False False IGHV1 IGKV9 Kappa None None None None None 6wo4 H L 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM 04/24/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody HC11 HOMO SAPIENS; RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 2.349 X-RAY DIFFRACTION 0.236 0.209 False True IGHV1 IGKV3 Kappa None None None None None 3fb6 A B 0 C protein voltage-gated potassium channel membrane protein/metal transport 11/18/08 KcsA Potassium channel in the partially open state with 16 A opening at T112 STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 3.0 X-RAY DIFFRACTION 0.255 0.248 False False IGHV1 IGKV5 Kappa None None None None None 4jam H L 0 IMMUNE SYSTEM 02/18/13 Crystal structure of broadly neutralizing anti-hiv-1 antibody ch103 HOMO SAPIENS homo sapiens homo sapiens Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D. 1.65 X-RAY DIFFRACTION 0.197 0.169 False True IGHV4 IGLV3 Lambda None None None None None 5k8a B A 0 IMMUNE SYSTEM 05/27/16 NIST FAB MUS MUSCULUS mus musculus mus musculus Gallagher, D.T., Galvin, C.V., Karageorgos, I., Marino, J.P. 1.999 X-RAY DIFFRACTION 0.189 0.164 False True IGHV2 IGKV1 Kappa None None None None None 3ulv F E 0 A protein toll-like receptor 3 IMMUNE SYSTEM 11/11/11 Structure of quaternary complex of human TLR3ecd with three Fabs (Form2) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Luo, J., Gilliland, G.L., Obmolova, O., Malia, T., Teplyakov, A. 3.522 X-RAY DIFFRACTION 0.253 0.231 False True IGHV1 IGKV12 Kappa None None None None None 3jbc 7 NA 0 3 protein NA capsid protein vp3 VIRUS/IMMUNE SYSTEM 08/26/15 Complex of Poliovirus with VHH PVSP29F CAMELUS DROMEDARIUS; HUMAN POLIOVIRUS 1 MAHONEY camelus dromedarius human poliovirus 1 mahoney Strauss, M., Schotte, L., Thys, B., Filman, D.J., Hogle, J.M. 5.6 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7jtg A B 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM/VIRAL PROTEIN 08/17/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM11-43 MACACA MULATTA; RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 macaca mulatta macaca mulatta recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 2.6 X-RAY DIFFRACTION 0.269 0.222 False True IGHV1 IGKV1 Kappa None None None None None 7m74 H L 0 A protein NA 5'-amp-activated protein kinase catalytic subunit alpha-1 SIGNALING PROTEIN 03/26/21 ATP-bound AMP-activated protein kinase HOMO SAPIENS; ESCHERICHIA COLI; LAMA GLAMA homo sapiens homo sapiens homo sapiens Yan, Y., Mukherjee, S., Harikumar, K.G., Strutzenberg, T., Zhou, X.E., Powell, S.K., Xu, T., Sheldon, R., Lamp, J., Brunzelle, J.S., Radziwon, K., Ellis, A., Novick, S.J., Vega, I.E., Jones, R., Miller, L.J., Xu, H.E., Griffin, P.R., Kossiakoff, A.A., Melcher, K. 3.93 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4r2g J I 0 K protein surface protein gp160 IMMUNE SYSTEM 08/11/14 Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (JRCSF ISOLATE); HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 (jrcsfisolate) Garces, F., Wilson, I.A. 3.283 X-RAY DIFFRACTION 0.263 0.207 False True IGHV4 IGLV3 Lambda 3.4e-08 -10.188885744060974 ITC TBD 7vag H L 0 A protein NA sodium/bile acid cotransporter TRANSPORT PROTEIN 08/29/21 Cryo-EM structure of human NTCP complexed with YN69202Fab in the presence of myristoylated preS1 peptide HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Asami, J., Shimizu, T., Ohto, U. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 5o8f M NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 06/13/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.2 X-RAY DIFFRACTION 0.242 0.232 False True IGHV1 NA NA None None None None None 5kwl 7 NA 0 3 protein vp3 VIRUS/Immune System 07/18/16 expanded poliovirus in complex with VHH 10E CAMELUS DROMEDARIUS; POLIOVIRUS TYPE 1 (STRAIN MAHONEY) camelus dromedarius poliovirus type 1 (strain mahoney) Strauss, M., Schotte, L., Filman, D.J., Hogle, J.M. 4.5 ELECTRON MICROSCOPY False True IGHV1 None None None None None 1kiq B A 0 C protein lysozyme COMPLEX (IMMUNOGLOBULIN/HYDROLASE) 10/23/96 FV MUTANT Y(B 101)F (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Fields, B.A., Poljak, R.J., Mariuzza, R.A. 1.85 X-RAY DIFFRACTION unknown 0.181 False True IGHV2 IGKV12 Kappa None None None None None 7niu C B 0 A protein NA isoform 2 of phosphatidylcholine translocator abcb4 PROTEIN TRANSPORT 02/14/21 Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (apo-inward-open conformation) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nosol, K., Locher, K.P. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7tdm H L 0 B protein NA heat-labile enterotoxin b chain MEMBRANE PROTEIN 01/01/22 CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain HOMO SAPIENS; CLOSTRIDIUM PERFRINGENS homo sapiens homo sapiens clostridium perfringens Vecchio, A.J. 6.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7zxf B C 0 A protein NA gametocyte surface protein p45/48 CELL ADHESION 05/20/22 Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 Mus musculus; Plasmodium falciparum; Rattus norvegicus rattus norvegicus rattus norvegicus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 3.72 X-RAY DIFFRACTION 0.298 0.281 False True IGHV5 IGLV3 Lambda None None None None None 4at6 M N 0 IMMUNE SYSTEM 05/04/12 Fab fragment of antiporphyrin antibody 14H7 MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Mahy, J.P. 2.549 X-RAY DIFFRACTION 0.3281 0.2791 False False IGHV1 IGLV1 Lambda None None None None None 7bnw A NA 0 NA NA NA NA IMMUNE SYSTEM 01/22/21 Llama nanobody nb18 raised against GldL from Flavobacterium jonhsoniae LAMA GLAMA lama glama Trinh, N.T., Cambillau, C., Leone, P. 2.59 X-RAY DIFFRACTION 0.243 0.193 False True IGHV1 NA NA None None None None None 7bep H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-384 and S309 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.61 X-RAY DIFFRACTION 0.241 0.203 False True IGHV1 IGKV3 Kappa None None None None None 5ocl E NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA lama glama Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 6kvf H L 0 b peptide NA unknown IMMUNE SYSTEM 09/04/19 Structure of anti-hCXCR2 abN48 in complex with its CXCR2 epitope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Xiang, J.C., Yan, L., Yang, B., Wilson, I.A. 2.79 X-RAY DIFFRACTION 0.264 0.228 False True IGHV1 IGLV5 Lambda None None None None None 6xe1 H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/20 Structure of SARS-CoV-2 spike protein receptor binding domain in complex with a potent neutralizing antibody, CV30 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hurlburt, N.K., Pancera, M. 2.75 X-RAY DIFFRACTION 0.239 0.212 False True IGHV3 IGKV3 Kappa None None None None None 5vgj H L 0 G protein 1fd6-v1v2-wito Viral protein/IMMUNE SYSTEM 04/11/17 Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90, bound to a scaffolded WITO V1V2 domain HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Li, J., Kwong, P.D. 3.456 X-RAY DIFFRACTION 0.273 0.214 False True IGHV3 IGKV2 Kappa None None None None None 3u79 NA C 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 4x7c C NA 0 A protein vp1 VIRAL PROTEIN 12/09/14 Crystal structure of Saga-2006 GII.4 P domain in complex with Nano-85 NOROVIRUS HU/GII-4/SAGA1/2006/JP; VICUGNA PACOS vicugna pacos norovirus hu/gii-4/saga1/2006/jp Koromyslova, A.D., Hansman, G.S. 2.0 X-RAY DIFFRACTION 0.218 0.166 False True IGHV1 None None None None None 6x8p H L 0 P peptide NA npnd peptide IMMUNE SYSTEM 06/01/20 Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein NPND peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium berghei anka Thai, E., Julien, J.P. 2.27 X-RAY DIFFRACTION 0.222 0.166 False True IGHV1 IGKV1 Kappa None None None None None 4gq9 H L 0 VIRAL PROTEIN 08/22/12 Chikungunya virus neutralizing antibody 9.8B Fab fragment MUS MUSCULUS mus musculus mus musculus Sun, S, Rossmann, M.G. 2.995 X-RAY DIFFRACTION 0.359 0.323 False False IGHV1 IGKV4 Kappa None None None None None 7teq M N 0 D | C protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 active conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 7.51 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 7te4 H L 0 NA NA NA NA IMMUNE SYSTEM 01/04/22 Crystal structure of Fab2 anti-GluN2B antibody MUS MUSCULUS mus musculus mus musculus Tajima, N., Furukawa, H. 2.456 X-RAY DIFFRACTION 0.297 0.261 False False IGHV5 IGKV19 Kappa None None None None None 7teb M N 0 B protein NA glutamate receptor ionotropic, nmda 2b SIGNALING PROTEIN/IMMUNE SYSTEM 01/04/22 Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 non-active1-like RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Tajima, N., Furukawa, H. 4.23 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV19 Kappa None None None None None 7k8p H L 0 NA NA NA NA IMMUNE SYSTEM 09/27/20 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C110 HOMO SAPIENS homo sapiens homo sapiens Dam, K.A., Barnes, C.O., Bjorkman, P.J. 1.8 X-RAY DIFFRACTION 0.229 0.196 False True IGHV5 IGKV1 Kappa None None None None None 1pg7 I M 0 IMMUNE SYSTEM 05/27/03 Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab SYNTHETIC CONSTRUCT; MUS MUSCULUS synthetic construct synthetic construct Eigenbrot, C., Meng, Y.G., Krishnamurthy, R., Lipari, M.T., Presta, L., Devaux, B., Wong, T., Moran, P., Bullens, S., Kirchhofer, D. 2.5 X-RAY DIFFRACTION 0.265 0.217 False True IGHV3 IGKV1 Kappa None None None None None 1vpo H L 0 H Hapten TES TESTOSTERONE IMMUNE SYSTEM 11/15/04 Crystal Structure Analysis of the Anti-testosterone Fab in Complex with Testosterone MUS MUSCULUS mus musculus mus musculus mus musculus Valjakka, J.M., Hemminki, A., Niemi, S., Soderlund, H., Takkinen, K., Rouvinen, J. 2.15 X-RAY DIFFRACTION 0.274 0.211 False True IGHV5 IGKV1 Kappa None None None None None 5wdu W X 0 Q protein envelope glycoprotein gp160 IMMUNE SYSTEM 07/06/17 HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Julien, J.-P., Torrents de la Pena, A., Sanders, R.W., Wilson, I.A. 7.0 X-RAY DIFFRACTION 0.363 0.301 False True unknown unknown unknown None None None None None 7po5 X F 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/08/21 Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 47C9 antibody Fab fragment HOMO SAPIENS; HUMAN CORONAVIRUS OC43 homo sapiens homo sapiens human coronavirus oc43 Hurdiss, D.L. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 2w0f A B 0 C protein voltage-gated potassium channel IMMUNE SYSTEM/METAL TRANSPORT 08/14/08 Potassium Channel KcsA-Fab Complex with Tetraoctylammonium MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Lenaeus, M.J., Focia, P.J., Wagner, T., Gross, A. 2.4 X-RAY DIFFRACTION 0.241 0.200 False True IGHV1 IGKV5 Kappa None None None None None 6h15 C NA 0 A protein low-density lipoprotein receptor-related protein 6 SIGNALING PROTEIN 07/11/18 Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Gros, P., van Scherpenzeel, R.C. 2.6 X-RAY DIFFRACTION 0.247 0.198 False True IGHV1 None None None None None 1mak NA A 10 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5y9f L K 0 A protein NA light chains of fab fragment of antibody 28f10 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 5vta F E 0 C protein dipeptidyl peptidase 4 HYDROLASE 05/16/17 Co-Crystal Structure of DPPIV with a Chemibody Inhibitor RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Johnstone, S., Cheng, A. 2.8 X-RAY DIFFRACTION 0.300 0.250 False True IGHV1 IGKV4 Kappa None None None None None 6d6t K L 0 D protein gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 TRANSPORT PROTEIN 04/22/18 Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhu, S., Noviello, C.M., Teng, J., Walsh Jr, R.M., Kim, J.J., Hibbs, R.E. 3.8 ELECTRON MICROSCOPY False False IGHV14 IGKV6 Kappa 6.1e-09 -11.20681521904132 Unknown TBD 4uu9 H L 0 D protein complement c5 07/25/14 Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Colley, C., Sridharan, S., Dobson, C., Popovic, B., Debreczeni, J.E., Hargreaves, D., Edwards, B., Brennan, J., England, L., Fung, S., An Eghobamien, L., Sivars, U., Woods, R., Flavell, L., Renshaw, G.J., Wickson, K., Wilkinson, T., Davies, R., Bonnell, J., Warrener, P., Howes, R., Vaughan, T. 2.12 X-RAY DIFFRACTION 0.20163 0.17456 False True IGHV3 IGLV2 Lambda 1.4e-11 -14.80733067454163 SPR TBD 6dzm I K 0 E | B protein | protein NA | NA bundibugyo virus gp2 | bundibugyo virus gp1 VIRAL PROTEIN 07/05/18 Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bundibugyo ebolavirus | bundibugyo ebolavirus Murin, C.D., Ward, A.B. 4.29 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6k68 A B 0 H protein protein a STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (8420-3MNZ) HUMAN IMMUNODEFICIENCY VIRUS 1; STAPHYLOCOCCUS AUREUS human immunodeficiency virus 1 human immunodeficiency virus 1 staphylococcus aureus Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 3.2 X-RAY DIFFRACTION 0.318 0.289 False True IGHV9 IGKV8 Kappa None None None None None 6icf H L 0 A protein putative zinc metalloprotease aq_1964,putative zincmetalloprotease aq_1964 SIGNALING PROTEIN 09/05/18 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA12 tag inserted between the residues 263 and 266 AQUIFEX AEOLICUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus aquifex aeolicus Tamura, R., Oi, R., Kaneko, M.K., Kato, Y., Nogi, T. 4.0 X-RAY DIFFRACTION 0.274 0.213 False True IGHV5 IGLV3 Lambda None None None None None 6wtu B C 0 A protein NA reticulocyte binding protein 2b CELL INVASION 05/04/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 273264 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.55 X-RAY DIFFRACTION 0.255 0.208 False True IGHV3 IGLV3 Lambda None None None None None 6nfn J I 0 J Hapten BCG 3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID IMMUNE SYSTEM 12/20/18 Fab fragement of anti-cocaine antibody h2E2 bound to benzoylecgonine MUS MUSCULUS mus musculus mus musculus mus musculus Pokkuluri, P.R., Tan, K. 2.63 X-RAY DIFFRACTION 0.244 0.185 False True IGHV3 IGLV2 Lambda None None None None None 7k9k H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 09/29/20 SARS-CoV-2 Spike RBD in complex with neutralizing Fab 2H04 (local refinement) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Errico, J.M., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.14 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 7nwl D E 0 B protein NA integrin beta-1 CELL ADHESION 03/17/21 Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Schumacher, S., Dedden, D., Vazquez Nunez, R., Matoba, K., Takagi, J., Biertumpfel, C., Mizuno, N. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV4 Kappa None None None None None 5xez C D 0 A protein glucagon receptor,endolysin,glucagon receptor SIGNALING PROTEIN 04/06/17 Structure of the Full-length glucagon class B G protein-coupled receptor HOMO SAPIENS homo sapiens homo sapiens homo sapiens, enterobacteria phage t4 Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.Y., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. 3.0 X-RAY DIFFRACTION 0.243 0.210 False True IGHV3 IGKV1 Kappa None None None None None 6kyz E F 0 D protein genome polyprotein VIRAL PROTEIN 05/27/20 HRV14 3C in complex with single chain antibody YDF HUMAN RHINOVIRUS 14; HOMO SAPIENS homo sapiens homo sapiens human rhinovirus 14 Meng, B., Yang, B., Wilson, I.A. 1.845 X-RAY DIFFRACTION 0.208 0.175 False True IGHV3 IGLV3 Lambda None None None None None 3s96 A B 0 IMMUNE SYSTEM 05/31/11 Crystal structure of 3B5H10 MUS MUSCULUS mus musculus mus musculus Weisgraber, K., Peters-Libeu, C., Rutenber, E., Newhouse, Y., Finkbeiner, S. 1.9 X-RAY DIFFRACTION 0.260 0.183 False False IGHV9 IGLV3 Lambda None None None None None 6mb3 F P 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 3mcg NA 2 0 IMMUNOGLOBULIN 05/09/89 THREE-DIMENSIONAL STRUCTURE OF A LIGHT CHAIN DIMER CRYSTALLIZED IN WATER. CONFORMATIONAL FLEXIBILITY OF A MOLECULE IN TWO CRYSTAL FORMS HOMO SAPIENS homo sapiens Ely, K.R., Herron, J.N., Edmundson, A.B. 2.0 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 1g9e A NA 1 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 7lok K J 0 A protein NA envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/10/21 Structure of CD4 mimetic M48U1 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Jette, C.A., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6pzz F E 0 B protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-80 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 2xkn D C 0 IMMUNE SYSTEM 07/09/10 Crystal structure of the Fab fragment of the anti-EGFR antibody 7A7 MUS MUSCULUS mus musculus mus musculus Talavera, A., Mackenzie, J., Friemann, R., Garrido, G., Lopez-Requena, A., Moreno, E., Krengel, U. 1.4 X-RAY DIFFRACTION 0.1765 0.1438 False False IGHV5 IGKV10 Kappa None None None None None 6dla H L 0 IMMUNE SYSTEM 05/31/18 Crystal structures of an influenza A hemagglutinin antibody Fab CH65:7969d2 HOMO SAPIENS homo sapiens homo sapiens Dong, J., Crowe, J.E., Finn, J.A. 2.004 X-RAY DIFFRACTION 0.207 0.178 False True IGHV1 IGLV3 Lambda None None None None None 1igt B A 0 IMMUNOGLOBULIN 10/25/96 STRUCTURE OF IMMUNOGLOBULIN MUS MUSCULUS mus musculus mus musculus Harris, L.J., Larson, S.B., Hasel, K.W., McPherson, A. 2.8 X-RAY DIFFRACTION 0.297 0.209 False False IGHV5 IGKV10 Kappa None None None None None 2p4a D NA 0 C protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Koide, A., Uysal, S., Koide, S. 1.9 X-RAY DIFFRACTION 0.218 0.184 False True IGHV1 1.80e-10 -13.51 Other 30 17888451 7r6x C D 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/23/21 SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2E12 Fab, S309 Fab, and S304 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Croll, T.I., Nix, J.C., Corti, D., Cameroni, E., Pinto, D., Beltramello, M. 2.95 X-RAY DIFFRACTION 0.262 0.232 False True IGHV1 IGKV3 Kappa None None None None None 6qb9 A a 0 APOPTOSIS 12/20/18 Structure of an anti-Mcl1 scFv HOMO SAPIENS homo sapiens Hargreaves, D. 1.85 X-RAY DIFFRACTION 0.239 0.200 True True unknown unknown unknown None None None None None 4aiz NA C 0 IMMUNE SYSTEM 02/15/12 Crystallographic structure of 3mJL2 from the germinal line lambda 3 HOMO SAPIENS homo sapiens Villalba, M.I., Luna, O.D., Rudino-Pinera, E., Sanchez, R., Sanchez-Lopez, R., Rojas-Trejo, S., Olamendi-Portugal, T., Fernandez-Velasco, D.A., Becerril, B. 1.75 X-RAY DIFFRACTION 0.2185 0.1662 False True IGLV3 Lambda None None None None None 3auv A a 0 IMMUNE SYSTEM 02/16/11 Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface HOMO SAPIENS homo sapiens Yu, C.M., Peng, H.P., Chen, I.C., Lee, Y.C., Chen, J.B., Tsai, K.C., Chen, C.T., Chang, J.Y., Yang, E.W., Hsu, P.C., Jian, J.W., Hsu, H.J., Chang, H.J., Hsu, W.L., Huang, K.F., Ma, A.C., Yang, A.S. 2.4 X-RAY DIFFRACTION 0.251 0.216 True True unknown unknown unknown None None None None None 5d1q C D 0 E protein iron-regulated surface determinant protein b IMMUNE SYSTEM 08/04/15 IsdB NEAT2 bound by clone D2-06 HOMO SAPIENS; STAPHYLOCOCCUS AUREUS (STRAIN BOVINE RF122 / ET3-1) homo sapiens homo sapiens staphylococcus aureus (strain bovine rf122 /et3-1) Deng, X. 3.22 X-RAY DIFFRACTION 0.288 0.239 False True IGHV3 IGKV3 Kappa 1.3e-11 -14.851238438600605 SPR TBD 4rwy H L 0 A protein hiv-1 yu2 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/08/14 Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC131 in complex with HIV-1 clade B YU2 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Luongo, T.S., Kwong, P.D. 2.128 X-RAY DIFFRACTION 0.254 0.219 False True unknown IGKV3 Kappa None None None None None 7x8r N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/14/22 Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex Bos taurus; Homo sapiens; Rattus norvegicus; synthetic construct synthetic construct bos taurus | rattus norvegicus Cong, Z.T., Zhou, Q.T., Li, Y., Chen, L.N., Zhang, Z.C., Liang, A.Y., Liu, Q., Wu, X.Y., Dai, A.T., Xia, T., Wu, W., Zhang, Y., Yang, D.H., Wang, M.W. 0 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6k2i A NA 0 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 6cyf D C 0 A protein type iii secretion system protein IMMUNE SYSTEM 04/05/18 PcrV fragment with bound Fab PSEUDOMONAS AERUGINOSA; HOMO SAPIENS homo sapiens homo sapiens pseudomonas aeruginosa Oganesyan, V. 2.78 X-RAY DIFFRACTION 0.249 0.215 False True IGHV3 IGKV1 Kappa None None None None None 1mpa H L 0 P peptide pora p1.16 peptide fluorescein conjugate COMPLEX (IMMUNOGLOBULIN/PEPTIDE) 02/26/97 BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS MUS MUSCULUS mus musculus mus musculus Van Den Elsen, J.M.H., Herron, J.N., Kroon, J., Gros, P. 2.6 X-RAY DIFFRACTION 0.309 0.194 False True IGHV1 IGKV1 Kappa 9.1e-09 -10.969830253718456 Unknown TBD 6u9u H L 0 IMMUNE SYSTEM 09/09/19 Structure of GM9_TH8seq732127 FAB HOMO SAPIENS homo sapiens homo sapiens Singh, S., Liban, T.J., Pancera, M. 2.26 X-RAY DIFFRACTION 0.250 0.208 False True IGHV4 IGKV1 Kappa None None None None None 4tnv H L 0 A protein avermectin-sensitive glutamate-gated chloride channel gluclalpha Transport Protein/immune System 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.6 X-RAY DIFFRACTION 0.283 0.261 False False IGHV1 IGLV1 Lambda None None None None None 6cwt A B 0 E protein capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 03/30/18 Hepatitis B core-antigen in complex with Fab e21 ORYCTOLAGUS CUNICULUS; HEPATITIS B VIRUS GENOTYPE D SUBTYPE ADW oryctolagus cuniculus oryctolagus cuniculus hepatitis b virus genotype d subtype adw Eren, E., Steven, A.C., Wingfield, P.T. 3.151 X-RAY DIFFRACTION 0.283 0.231 False True IGHV1 IGKV1 Kappa 2e-12 -15.960250680603272 AUC TBD 6oc8 A NA 0 IMMUNE SYSTEM 03/22/19 Crystal structure of a VHH against the capsid protein from BLV LAMA GLAMA lama glama Carrion, F., Larrieux, N., Trajtenberg, F., Buschiazzo, A. 2.109 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 None None None None None 7rg7 A NA 0 A Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoclamp8:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Peat, T., Newman, J., Alexandrov, K. 1.83 X-RAY DIFFRACTION 0.202 0.149 False True IGHV1 NA NA None None None None None 7n9v E NA 0 D protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/21 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Tripler, T.N. 3.45 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 NA NA None None None None None 5nyx O P 0 IMMUNE SYSTEM 05/12/17 human Fab fragment 5H2 against NHBA from Neisseria meningitidis HOMO SAPIENS homo sapiens homo sapiens Enrico, M., Maritan, M. 1.88 X-RAY DIFFRACTION 0.226 0.186 False True IGHV4 IGKV1 Kappa None None None None None 5vxj H NA 0 G protein NA invasin ipad IMMUNE SYSTEM 05/23/17 2.50 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-E3 SHIGELLA FLEXNERI; VICUGNA PACOS vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.5 X-RAY DIFFRACTION 0.259 0.196 False True IGHV1 NA NA None None None None None 5bk3 H L 0 L carbohydrate NAG polysaccharide IMMUNE SYSTEM 09/12/17 Crystal structure of the neutralizing anti-circumsporozoite protein 580 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 2.8 X-RAY DIFFRACTION 0.231 0.190 False True IGHV3 IGKV4 Kappa None None None None None 7f7h C D 0 F protein NA spike glycoprotein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/29/21 SARS-CoV-2 S protein RBD in complex with A8-1 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dou, Y., Wang, X., Wang, K., Liu, P., Lu, B. 3.19 X-RAY DIFFRACTION 0.275 0.205 False True IGHV3 IGKV1 Kappa None None None None None 5e2u H L 0 IMMUNE SYSTEM 10/01/15 Structure of anti-TAU AT8 FAB in the presence of phosphopeptide MUS MUSCULUS mus musculus mus musculus Malia, T., Teplyakov, A. 2.4 X-RAY DIFFRACTION 0.248 0.186 False True IGHV3 IGKV2 Kappa None None None None None 6mef H L 0 IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.256 0.221 False True IGHV1 IGKV3 Kappa None None None None None 7d5p D NA 0 B protein NA drug transporter, putative MEMBRANE PROTEIN 09/27/20 Structure of NorC transporter in an outward-open conformation in complex with a single-chain Indian camelid antibody STAPHYLOCOCCUS AUREUS SUBSP. AUREUS COL; CAMELUS DROMEDARIUS camelus dromedarius staphylococcus aureus subsp. aureus col Kumar, S., Athreya, A., Penmatsa, A. 3.65 X-RAY DIFFRACTION 0.318 0.297 False True IGHV1 NA NA None None None None None 6iap E D 0 A protein natural cytotoxicity triggering receptor 1 IMMUNE SYSTEM 11/27/18 structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Roussel, A., Amigues, B. 2.9 X-RAY DIFFRACTION 0.263 0.187 False True IGHV1 IGKV12 Kappa None None None None None 3cm9 A L 8 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4gxv I M 0 IMMUNE SYSTEM 09/04/12 Crystal structure of anti-influenza virus antibody 1F1 HOMO SAPIENS homo sapiens homo sapiens Ekiert, D.C., Wilson, I.A. 1.449 X-RAY DIFFRACTION 0.207 0.181 False True IGHV3 IGLV1 Lambda None None None None None 7tyl N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/13/22 Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3u4e A B 0 J protein v1v2 region of hiv-1 on 1fd6 scaffold IMMUNE SYSTEM 10/07/11 Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain CAP45 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., McLellan, J., Pancera, M., Kwong, P.D. 2.185 X-RAY DIFFRACTION 0.234 0.182 False True IGHV3 IGLV2 Lambda None None None None None 4nik B b 0 A protein 26s proteasome non-atpase regulatory subunit 10 Oncoprotein/Immune System 11/06/13 Structure of human Gankyrin in complex to the single chain antibody F5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Sato, Y., Weiss, E., Rochel, N. 2.5 X-RAY DIFFRACTION 0.208 0.164 True True unknown unknown unknown None None None None None 3l5w H L 0 I protein interleukin-13 IMMUNE SYSTEM 12/22/09 Crystal structure of the complex between IL-13 and C836 FAB MUS MUSCULUS, HOMO SAPIENS; HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.0 X-RAY DIFFRACTION 0.253 0.205 False True IGHV8 IGKV16 Kappa 5.40e-11 -14 SPR 25 20226193 5mvj A B 0 IMMUNE SYSTEM 01/16/17 Structure of DC8E8 Fab at pH 6.5 crystallized in space-group P1 MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.5 X-RAY DIFFRACTION 0.272 0.219 False False IGHV1 IGKV8 Kappa None None None None None 5ig7 D E 0 F peptide peptide pro-leu-gln-pro-gln-gln-pro-phe-pro IMMUNE SYSTEM 02/27/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPQQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.97 X-RAY DIFFRACTION 0.236 0.190 False True IGHV3 IGLV4 Lambda None None None None None 5myo B A 0 E peptide amyloid beta a4 protein IMMUNE SYSTEM 01/27/17 Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Parthier, C., Piechotta, A., Stubbs, M.T. 1.59 X-RAY DIFFRACTION 0.215 0.178 False True IGHV1 IGKV1 Kappa 2.93e-11 -14.369763591907674 Unknown TBD 3j8v H L 0 E protein NA l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.14J Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 13.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV13 Kappa None None None None None 6b5t H L 0 A peptide pfcsp peptide 29pro-asn-ala IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 29 with human antibody CIS42 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 2.222 X-RAY DIFFRACTION 0.209 0.183 False True IGHV7 IGLV2 Lambda 2.21e-09 -11.808361680878818 Unknown TBD 3cm9 C N 8 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6orq D E 0 B protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS mus musculus mus musculus human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 4uv7 H L 0 A protein epidermal growth factor receptor 08/05/14 The complex structure of extracellular doamin of EGFR and GC1118A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yoo, J.H., Cho, H.S. 2.1 X-RAY DIFFRACTION 0.24759 0.20199 False True IGHV3 IGKV2 Kappa None None None None None 7lu9 h g 0 e protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta human immunodeficiency virus 1 Manne, K., Edwards, R.J., Acharya, P. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 6pzw H L 0 A protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-22 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 6pis H L 0 B protein potassium channel subfamily k member 4 ION TRANSPORT, MEMBRANE PROTEIN 06/27/19 Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure MUS MUSCULUS; CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius mus musculus Brohawn, S.G. 2.77 X-RAY DIFFRACTION 0.286 0.248 False False IGHV3 IGKV22 Kappa None None None None None 4v1d D E 0 C protein beta-mammal toxin cn2 09/25/14 Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius. HOMO SAPIENS; CENTRUROIDES NOXIUS homo sapiens homo sapiens centruroides noxius RIANO-UMBARILA, L., SERRANO-POSADA, H., ROJAS-TREJO, S., RUDINO-PINERA, E., BECERRIL, B. 3.1 X-RAY DIFFRACTION 0.2294 0.1848 False True IGHV3 IGLV1 Lambda None None None None None 2kqn NA B 12 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 3qyc B NA 0 IMMUNE SYSTEM 03/03/11 Structure of a dimeric anti-HER2 single domain antibody homo sapiens Baral, T.N., Chao, S., Li, S., Tanha, J., Arbabai, M., Wang, S., Zhang, J. 1.6 X-RAY DIFFRACTION 0.229 0.209 False True IGHV3 None None None None None 4ydv B A 0 Q peptide hiv gp41 peptide gp41(596-606) IMMUNE SYSTEM 02/23/15 STRUCTURE OF THE ANTIBODY 7B2 THAT CAPTURES HIV-1 VIRIONS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Nicely, N.I., Pemble IV, C.W. 2.7 X-RAY DIFFRACTION 0.223 0.189 False True IGHV3 IGKV4 Kappa None None None None None 5whz NA L 0 IMMUNE SYSTEM 07/18/17 PGDM1400-10E8v4 CODV Fab HOMO SAPIENS homo sapiens Lord, D.M., Wei, R.R. 3.549 X-RAY DIFFRACTION 0.287 0.239 False True IGLV3 Lambda None None None None None 7kmd H L 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/02/20 Crystal structure of a HIV-1 clade C isolate Du172.17 HR1.R4.664 Env trimer in complex with human Fabs PGT124 and 35O22 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 3.39229 X-RAY DIFFRACTION 0.292 0.242 False True IGHV4 unknown unknown None None None None None 6k42 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/23/19 cryo-EM structure of alpha2BAR-Gi1 complex BOS TAURUS; MUS MUSCULUS; HOMO SAPIENS; ENTEROBACTERIA PHAGE RB59 mus musculus bos taurus | mus musculus Daopeng, Y., Zhongmin, L., Hongwei, W., Brian, K. 4.1 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 7p78 W NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 1up/1up-out/1down conformation SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 3.32 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6ssi G NA 0 B protein cys-loop ligand-gated ion channel TRANSPORT PROTEIN 09/07/19 Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J. 2.59 X-RAY DIFFRACTION 0.246 0.230 False True IGHV1 None None None None None 4i9w G F 0 B protein potassium channel subfamily k member 4 METAL TRANSPORT 12/05/12 Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Brohawn, S.G., Mackinnon, R. 2.75 X-RAY DIFFRACTION 0.236 0.201 False True IGHV1 IGKV4 Kappa None None None None None 7k37 L K 0 E | F protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 7.8 INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Xiang, Y., Gao, J. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6ikm G g 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 5gzn H L 0 A | E protein | protein NA | NA genome polyprotein | genome polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/16 Structure of neutralizing antibody bound to Zika envelope protein ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus | zika virus Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F. 3.0 X-RAY DIFFRACTION 0.258 0.223 False True IGHV3 IGLV1 Lambda None None None None None 3j30 D C 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab CHK152 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 16 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 6qkd NA L 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGKV3 Kappa None None None None None 6vlw H L 0 G protein NA 426cod IMMUNE SYSTEM/VIRAL PROTEIN 01/27/20 Crystal Structure of 426cOD in Complex with VRC01 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Weidle, C., Pancera, M. 3.42 X-RAY DIFFRACTION 0.261 0.210 False True unknown IGKV3 Kappa None None None None None 7e8c S U 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6vup A a 0 NA NA NA NA PROTEIN BINDING 02/16/20 Reverse Transcriptase Diabody with R83T/E85C Mutations HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 1.4 X-RAY DIFFRACTION 0.171 0.131 True True unknown unknown unknown None None None None None 5vl2 F NA 0 F Hapten 9EG N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea UNKNOWN FUNCTION 04/24/17 The hapten triclocarban bound to the single domain camelid nanobody VHH T4 LAMA GLAMA lama glama lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.263 0.219 False True IGHV1 NA NA None None None None None 6q1e H L 0 IMMUNE SYSTEM 08/03/19 Inferred precursor (UCA) of the human antibody lineage 652 HOMO SAPIENS homo sapiens homo sapiens McCarthy, K.R., Harrison, S.C. 2.5 X-RAY DIFFRACTION 0.257 0.223 False True IGHV4 IGLV3 Lambda None None None None None 5u8r H L 0 A protein insulin-like growth factor 1 receptor TRANSFERASE/IMMUNE SYSTEM 12/14/16 Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Lawrence, M., Xu, Y. 3.00002 X-RAY DIFFRACTION 0.285 0.256 False True IGHV1 IGKV5 Kappa None None None None None 7lpn I NA 0 F protein NA envelope glycoprotein gp160 VIRAL PROTEIN 02/12/21 Cryo-EM structure of llama J3 VHH antibody in complex with HIV-1 Env BG505 DS-SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.61 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6sv2 H L 0 A protein NA major prion protein PROTEIN BINDING 09/17/19 Human prion protein (PrP) fragment 119-231 (G127V M129 variant) complexed to ICSM 18 (anti-Prp therapeutic antibody) Fab fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Conners, R. 2.3 X-RAY DIFFRACTION 0.251 0.200 False False IGHV1 IGKV4 Kappa None None None None None 6mu6 H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/22/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-814508 in Complex with Human Antibodies 3H109L and 35O22 at 3.2 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.551 X-RAY DIFFRACTION 0.264 0.231 False True IGHV4 unknown unknown None None None None None 4qci B A 0 D protein platelet-derived growth factor subunit b CYTOKINE/CYTOKINE RECEPTOR 05/12/14 PDGF-B blocking antibody bound to PDGF-BB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kuai, J., Mosyak, L., Tam, M., LaVallie, E., Pullen, N., Carven, G. 2.3 X-RAY DIFFRACTION 0.247 0.211 False True IGHV3 IGLV3 Lambda 2.8e-11 -14.396652282221849 SPR TBD 2qtj B M 7 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7kd6 I J 0 K protein NA insulin receptor subunit alpha SIGNALING PROTEIN 10/08/20 Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G. 2.6 X-RAY DIFFRACTION 0.221 0.189 False True IGHV2 IGKV8 Kappa None None None None None 4dtg H L 0 K protein tissue factor pathway inhibitor BLOOD CLOTTING INHIBITOR/IMMUNE SYSTEM 02/21/12 Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model HOMO SAPIENS homo sapiens homo sapiens homo sapiens Svensson, L.A., Breinholt, J., Krogh, B.O., Hilden, I. 1.8 X-RAY DIFFRACTION 0.236 0.196 False True IGHV3 IGKV2 Kappa 7.299999999999999e-11 -13.82890187434071 SPR TBD 6pdx H L 0 A protein hemagglutinin IMMUNE SYSTEM 06/19/19 Crystal structure of C585 Fab in complex with influenza virus hemagglutinin from A/Switzerland/9715293/2013 (H3N2) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Qiu, Y., Zhou, Y. 3.993 X-RAY DIFFRACTION 0.242 0.212 False True IGHV4 IGLV1 Lambda None None None None None 1kip B A 0 C protein lysozyme COMPLEX (IMMUNOGLOBULIN/HYDROLASE) 10/23/96 FV MUTANT Y(B 32)A (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Fields, B.A., Poljak, R.J., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION unknown 0.162 False True IGHV2 IGKV12 Kappa None None None None None 7q4q D C 0 F peptide NA lrg1 epitope IMMUNE SYSTEM 11/01/21 Magacizumab Fab fragment in complex with human LRG1 epitope MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Gutierrez-Fernandez, J., Luecke, H. 1.65 X-RAY DIFFRACTION 0.207 0.183 False False IGHV1 IGKV3 Kappa None None None None None 6dkj A B 0 D protein gastric inhibitory polypeptide receptor SIGNALING PROTEIN 05/29/18 human GIPR ECD and Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Min, X., Wang, Z. 1.95 X-RAY DIFFRACTION 0.238 0.199 False True IGHV3 IGKV3 Kappa None None None None None 4np4 H L 0 A protein toxin b IMMUNE SYSTEM 11/20/13 Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab CLOSTRIDIUM DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens clostridium difficile Orth, P., Xiao, L., Hernandez, L.D., Reichert, P., Sheth, P., Beaumont, M., Murgolo, N., Ermakov, G., DiNunzio, E., Racine, F., Karczewski, J., Secore, S., Ingram, R.N., Mayhood, T., Strickland, C., Therien, A.G. 2.89 X-RAY DIFFRACTION 0.232 0.198 False False IGHV5 IGKV3 Kappa 1.9e-11 -14.626397031011077 SPR TBD 7lse H L 0 E protein NA envelope protein e IMMUNE SYSTEM/VIRAL PROTEIN 02/18/21 Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Far Eastern Subtype) HOMO SAPIENS; TICK-BORNE ENCEPHALITIS VIRUS FAR EASTERN SUBTYPE homo sapiens homo sapiens tick-borne encephalitis virus far easternsubtype Keeffe, J.R., Bjorkman, P.J. 2.35 X-RAY DIFFRACTION 0.211 0.173 False True IGHV3 IGKV3 Kappa None None None None None 6z7z D C 0 F | E peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Porcine insulin in complex with the analytical antibody OXI-005 Fab MUS MUSCULUS; SUS SCROFA mus musculus mus musculus sus scrofa | sus scrofa Johansson, E. 2.4 X-RAY DIFFRACTION 0.259 0.210 False True IGHV5 IGKV19 Kappa None None None None None 3q6f J I 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 3.192 X-RAY DIFFRACTION 0.243 0.199 False False IGHV3 IGLV3 Lambda None None None None None 2zck H L 0 P protein prostate-specific antigen IMMUNE SYSTEM 11/09/07 Crystal structure of a ternary complex between PSA, a substrat-acyl intermediate and an activating antibody HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Menez, R., Stura, E., Jolivet-Reynaud, C. 3.1 X-RAY DIFFRACTION 0.275 0.221 False False IGHV1 IGKV3 Kappa None None None None None 6mu7 D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/22/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-818251 in Complex with Human Antibodies 3H109L and 35O22 at 3.1 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.501 X-RAY DIFFRACTION 0.261 0.223 False True unknown unknown unknown None None None None None 3v7a F G 0 B protein capsid IMMUNE SYSTEM 12/20/11 Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle HUMAN CALICIVIRUS; MUS MUSCULUS mus musculus mus musculus human calicivirus Hansman, G.S., Mclellan, J.S., Kwong, P.D. 3.297 X-RAY DIFFRACTION 0.283 0.227 False False IGHV1 IGKV12 Kappa None None None None None 3ogo H NA 0 B protein green fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 08/17/10 Structure of the GFP:GFP-nanobody complex at 2.8 A resolution in spacegroup P21212 AEQUOREA VICTORIA; CAMELUS DROMEDARIUS camelus dromedarius aequorea victoria Kubala, M.H., Kovtun, O., Alexandrov, K., Collins, B.M. 2.8 X-RAY DIFFRACTION 0.253 0.202 False True IGHV1 1.40e-09 -12.56 Other 37 20945358 6cmi D C 0 B protein glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 03/05/18 Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent Cross-Reactive Neutralizing Human Monoclonal Antibody m102.3 HENDRA VIRUS; HOMO SAPIENS homo sapiens homo sapiens hendra virus Xu, K., Nikolov, D. 2.72 X-RAY DIFFRACTION 0.246 0.196 False True IGHV1 IGKV3 Kappa None None None None None 7jhh N NA 0 NA NA NA NA TRANSFERASE/IMMUNE SYSTEM 07/20/20 Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody HOMO SAPIENS; ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct Yan, Y., Murkherjee, S., Zhou, X.E., Xu, T.H., Xu, H.E., Kossiakoff, A.A., Melcher, K. 3.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7d5q C NA 0 A protein NA drug transporter, putative MEMBRANE PROTEIN 09/27/20 Structure of NorC transporter (K398A mutant) in an outward-open conformation in complex with a single-chain Indian camelid antibody STAPHYLOCOCCUS AUREUS SUBSP. AUREUS COL; CAMELUS DROMEDARIUS camelus dromedarius staphylococcus aureus subsp. aureus col Kumar, S., Athreya, A., Penmatsa, A. 3.6 X-RAY DIFFRACTION 0.315 0.308 False True IGHV1 NA NA None None None None None 6nij H L 0 E | A | C protein | protein | protein NA | NA | NA amc011 glycoprotein 120 | amc011 glycoprotein 120 | amc011 glycoprotein 120 IMMUNE SYSTEM 12/29/18 PGT145 Fab in complex with full length AMC011 HIV-1 Env HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens | homo sapiens Cottrell, C.A., Torrents de la Pena, A., Rantalainen, K., Torres, J.L., Ward, A.B. 5.7 ELECTRON MICROSCOPY False True IGHV1 IGKV2 Kappa None None None None None 4nry A B 0 IMMUNE SYSTEM 11/27/13 Crystal Structure of HIV-1 Neutralizing Antibody m66 HOMO SAPIENS homo sapiens homo sapiens Ofek, G., Yang, Y., Kwong, P.D. 3.14 X-RAY DIFFRACTION 0.256 0.228 False True IGHV5 IGKV1 Kappa None None None None None 7ben D F 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253 and COVOX-75 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.5 X-RAY DIFFRACTION 0.282 0.240 False True IGHV1 IGKV3 Kappa None None None None None 7v5n F E 0 G nucleic-acid NA dna (5'-d(*gp*cp*gp*gp*tp*tp*gp*gp*tp*gp*gp*tp*ap*gp*tp*tp*ap*cp*gp*tp*tp*cp* gp*c)-3') IMMUNE SYSTEM/DNA 08/17/21 Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Hishiki, A., Tong, J., Todoroki, K., Hashimoto, H. 1.7 X-RAY DIFFRACTION 0.210 0.178 False True IGHV3 IGKV1 Kappa None None None None None 6mwn H L 0 A nucleic-acid hav dv rna (92-mer) RNA/Immune System 10/29/18 Crystal structure of hepatitis A virus IRES domain V in complex with Fab HAVx HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatovirus a Koirala, D., Shao, Y., Piccirilli, J.A. 2.838 X-RAY DIFFRACTION 0.252 0.186 False True IGHV3 IGKV1 Kappa None None None None None 5n7w A B 0 Y protein interleukin-17a IMMUNE SYSTEM 02/21/17 Computationally designed functional antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hargreaves, D., Breed, J. 1.96 X-RAY DIFFRACTION 0.250 0.199 False True IGHV1 IGKV1 Kappa 8e-08 -9.681917538322692 SPR TBD 5a16 E F 0 04/28/15 Crystal structure of Fab4201 raised against Human Erythrocyte Anion Exchanger 1 MUS MUSCULUS mus musculus mus musculus Arakawa, T., Kobayashi-Yugiri, T., Alguel, Y., Weyand, S., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Ikeda-Suno, C., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A., Kobayashi, T., Hamasaki, N., Iwata, S. 2.5 X-RAY DIFFRACTION 0.2552 0.2128 False False IGHV8 IGKV3 Kappa None None None None None 6ot1 q r 0 G protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False False unknown IGKV3 Kappa None None None None None 1g9e A NA 17 NA NA NA NA IMMUNE SYSTEM 11/23/00 SOLUTION STRUCTURE AND RELAXATION MEASUREMENTS OF AN ANTIGEN-FREE HEAVY CHAIN VARIABLE DOMAIN (VHH) FROM LLAMA LAMA GLAMA lama glama Renisio, J.-G., Perez, J., Czisch, M., Guenneugues, M., Bornet, O., Frenken, L., Cambillau, C., Darbon, H. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6ad0 H L 0 A | C | B protein | protein | protein NA | NA | NA vp1 | vp3 | vp2 VIRUS/IMMUNE SYSTEM 07/28/18 The structure of CVA10 mature virion in complex with Fab 2G8 MUS MUSCULUS; COXSACKIEVIRUS A10 mus musculus mus musculus coxsackievirus a10 | coxsackievirus a10 | coxsackievirus a10 Zhu, R., Zheng, Q.B., Xu, L.F., Cui, Y.X., Li, S.W., Yan, X.D., Zhou, Z.H., Cheng, T. 3.9 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 1yy8 B A 0 IMMUNE SYSTEM 02/24/05 Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Li, S., Schmitz, K.R., Jeffrey, P.D., Wiltzius, J.J.W., Kussie, P., Ferguson, K.M. 2.0 X-RAY DIFFRACTION 0.264 0.224 False True IGHV2 IGKV5 Kappa None None None None None 6ks0 H L 0 A protein NA adiponectin receptor protein 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 08/22/19 Crystal structure of the human adiponectin receptor 1 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S. 2.79 X-RAY DIFFRACTION 0.277 0.221 False True IGHV1 IGKV12 Kappa None None None None None 1mjj B A 0 A Hapten HAL N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE IMMUNE SYSTEM 08/28/02 HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12 AND A TRANSITION-STATE ANALOG MUS MUSCULUS mus musculus mus musculus mus musculus Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W. 2.1 X-RAY DIFFRACTION 0.256 0.178 False True IGHV1 IGKV2 Kappa 1.83e-09 -11.920149456768272 Unknown TBD 7e7x M N 0 B protein NA spike protein s1 VIRAL PROTEIN 02/28/21 SARS-CoV-2 Spike Protein N terminal domain in Complex with N11 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, Z., Shuo, D., Xiao, J. 2.78 X-RAY DIFFRACTION 0.279 0.248 False True IGHV1 IGLV2 Lambda None None None None None 2kqn NA B 6 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7rth q NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 3rhw H L 0 A protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.26 X-RAY DIFFRACTION 0.270 0.239 False True IGHV1 IGLV1 Lambda None None None None None 6p62 H L 0 A protein hiv-1 env bg505 nfl td+ VIRAL PROTEIN/immune system 05/31/19 HIV Env BG505 NFL TD+ in complex with antibody E70 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 3qq9 H L 0 IMMUNE SYSTEM 02/15/11 Crystal structure of FAB fragment of anti-human RSV (RESPIRATORY SYNCYTIAL VIRUS) F Protein MAB 101F HOMO SAPIENS, MUS MUSCULUS homo sapiens, mus musculus homo sapiens, mus musculus Luo, J., Tsui, P., Spurlino, J., Lewansowski, F., Heavner, G.A., Del Vecchio, F. 1.64 X-RAY DIFFRACTION 0.217 0.173 False True IGHV8 IGKV3 Kappa None None None None None 2ht4 C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/25/06 Structure of the Escherichia coli ClC chloride channel Y445W mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.2 X-RAY DIFFRACTION 0.261 0.239 False False IGHV4 IGKV4 Kappa None None None None None 4aei J N 0 C protein alpha-mammal toxin aah2 IMMUNE SYSTEM/TOXIN 01/10/12 Crystal structure of the AaHII-Fab4C1 complex ANDROCTONUS AUSTRALIS HECTOR; MUS MUSCULUS mus musculus mus musculus androctonus australis hector Fabrichny, I.P., Mondielli, G., Conrod, S., Martin-Eauclaire, M.F., Bourne, Y., Marchot, P. 2.3 X-RAY DIFFRACTION 0.25403 0.19862 False False IGHV5 IGKV1 Kappa 8.000000000000001e-10 -12.410405717143199 Unknown TBD 6mns H L 0 P peptide envelope glylcoprotein IMMUNE SYSTEM 10/02/18 Rhesus macaque anti-HIV V3 antibody DH753 with gp120 V3 ZAM18 peptide MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Nicely, N.I. 2.7 X-RAY DIFFRACTION 0.256 0.170 False True IGHV3 IGLV1 Lambda None None None None None 6mhg C P 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6xob O P 0 E protein NA togavirin Virus/Immune System 07/06/20 CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP with Fab EEEV-143. EASTERN EQUINE ENCEPHALITIS VIRUS; HOMO SAPIENS homo sapiens homo sapiens eastern equine encephalitis virus Binshtein, E., Crowe, J.E. 8.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7k8x E G 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/27/20 Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Abernathy, M.E., Barnes, C.O., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6ui1 B NA 0 A protein bont/a TOXIN/ANTITOXIN 09/29/19 Crystal structure of BoNT/A-LCHn domain in complex with VHH ciA-D12, ciA-B5, and ciA-H7 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.20001 X-RAY DIFFRACTION 0.229 0.181 False True IGHV1 None None None None None 6p8m H L 0 C protein gp120 IMMUNE SYSTEM 06/07/19 Crystal Structure of Antibody P-p3b3 A60C Heavy Chain in Complex with 426c HIV-1 gp120 core G459C HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Weidle, C., Pancera, M. 3.594 X-RAY DIFFRACTION 0.268 0.232 False True IGHV1 IGKV8 Kappa None None None None None 7che A B 0 R protein NA sars-cov-2 receptor binding domain ANTIVIRAL PROTEIN/IMMUNE SYSTEM 07/05/20 Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab and BD-368-2 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xiao, J., Zhu, Q. 3.416 X-RAY DIFFRACTION 0.239 0.225 False True IGHV3 IGKV2 Kappa None None None None None 4zxb A B 0 E protein insulin receptor HORMONE RECEPTOR/IMMUNE SYSTEM 05/20/15 Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Croll, T., Smith, B.J., Margetts, M.B., Whittaker, J., Weiss, M.A., Ward, C.W., Lawrence, M.C. 3.3 X-RAY DIFFRACTION 0.237 0.205 False True IGHV2 IGKV8 Kappa None None None None None 6eay H L 0 A | B protein | protein NA | NA envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN 08/03/18 Structural Basis for Broad Neutralization of Ebolaviruses by an Antibody Targeting the Glycoprotein Fusion Loop MACACA FASCICULARIS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76) macaca fascicularis macaca fascicularis zaire ebolavirus (strain mayinga-76) | zaire ebolavirus (strain mayinga-76) Janus, B.M., Ofek, G. 3.72 X-RAY DIFFRACTION 0.297 0.259 False True IGHV4 IGKV1 Kappa None None None None None 6x1s E F 0 G peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC1-1) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 1.65 X-RAY DIFFRACTION 0.226 0.200 False True IGHV1 IGKV1 Kappa None None None None None 6ce0 H L 0 G protein envelope glycoprotein gp160 viral protein/immune system 02/09/18 Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Sarkar, A., Wilson, I.A. 4.602 X-RAY DIFFRACTION 0.341 0.313 False True IGHV4 unknown unknown None None None None None 1fns H L 0 A protein von willebrand factor IMMUNE SYSTEM 08/23/00 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Varughese, K.I. 2.0 X-RAY DIFFRACTION 0.207 0.172 False False IGHV2 IGKV10 Kappa None None None None None 7zfe F G 0 B protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-32 Fab and nanobody C1 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.25 X-RAY DIFFRACTION 0.293 0.237 False True IGHV3 IGKV3 Kappa None None None None None 4oii H L 0 A protein non-structural protein ns1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/14 West Nile Virus NS1 in complex with neutralizing 22NS1 antibody Fab WEST NILE VIRUS; MUS MUSCULUS mus musculus mus musculus west nile virus Edeling, M.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.0 X-RAY DIFFRACTION 0.265 0.214 False True IGHV1 IGKV12 Kappa None None None None None 7kkj C NA 0 NA NA NA NA IMMUNE SYSTEM 10/27/20 Structure of anti-SARS-CoV-2 Spike nanobody mNb6 SYNTHETIC CONSTRUCT synthetic construct Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 2.05 X-RAY DIFFRACTION 0.248 0.212 False True IGHV1 NA NA None None None None None 3juy C c 0 IMMUNE SYSTEM 09/15/09 Crystal Structure of a 3B3 Variant, a Broadly Neutralizing HIV-1 scFv Antibody HOMO SAPIENS homo sapiens Clark, K.R., Walsh, S.T. 2.5 X-RAY DIFFRACTION 0.260 0.195 True True unknown unknown unknown None None None None None 1iai I M 0 COMPLEX (IMMUNOGLOBULIN IGG1/IGG2A) 12/28/93 IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX MUS MUSCULUS mus musculus mus musculus Ban, N., Escobar, C., Garcia, R., Hasel, K., Day, J., Greenwood, A., McPherson, A. 2.9 X-RAY DIFFRACTION unknown 0.210 False False IGHV6 IGKV4 Kappa None None None None None 6qpg O NA 0 G | H protein | protein NA | NA polymerase acidic protein | rna-directed rna polymerase catalytic subunit RNA BINDING PROTEIN 02/13/19 Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205 INFLUENZA A VIRUS (STRAIN A/NORTHERN TERRITORY/60/1968 H3N2); CAMELIDAE camelidae influenza a virus (strain a/northernterritory/60/1968 h3n2) | influenza a virus (strain a/northernterritory/60/1968 h3n2) Fan, H.T., Keown, J.R., Fodor, E., Grimes, J.M. 3.34 X-RAY DIFFRACTION 0.305 0.251 False True IGHV3 NA NA None None None None None 4hfu H L 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 10/05/12 Crystal structure of Fab 8M2 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.106 X-RAY DIFFRACTION 0.251 0.193 False True IGHV1 IGKV3 Kappa None None None None None 5ihz E F 0 IMMUNE SYSTEM 03/01/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.64 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGLV4 Lambda None None None None None 3giz H L 0 IMMUNE SYSTEM 03/07/09 Crystal structure of the Fab fragment of anti-CD20 antibody Ofatumumab HOMO SAPIENS homo sapiens homo sapiens Du, J., Yang, H., Ding, J. 2.2 X-RAY DIFFRACTION 0.250 0.195 False True IGHV3 IGKV3 Kappa None None None None None 5uk4 e NA 0 E protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 6cuf Q R 0 C protein envelope glycoprotein gp41 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 4fg6 C D 0 A protein h(+)/cl(-) exchange transporter clca transport protein 06/04/12 Structure of EcCLC E148A mutant in Glutamate MUS MUSCULUS; SHIGELLA SONNEI mus musculus mus musculus shigella sonnei Feng, L., MacKinnon, R. 3.019 X-RAY DIFFRACTION 0.274 0.237 False True IGHV4 IGKV4 Kappa None None None None None 3j8d a A 0 B protein glycoprotein diii VIRUS/IMMUNE SYSTEM 10/13/14 Cryoelectron microscopy of dengue-Fab E104 complex at pH 5.5 DENGUE VIRUS 2 THAILAND/16681/84; UNIDENTIFIED unidentified dengue virus 2 thailand/16681/84 Zhang, X.Z., Sheng, J., Austin, S.K., Hoornweg, T., Smit, J.M., Kuhn, R.J., Diamond, M.S., Rossmann, M.G. 26 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6yye D d 0 B protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 05/04/20 TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scFv-2) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Krojer, T., Mukhopadhyay, S.M.M., McKinley, G., Graslund, S., Wigren, E., Persson, H., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Di Daniel, E., Burgess-Brown, N., Bullock, A. 3.36 X-RAY DIFFRACTION 0.327 0.299 True True unknown unknown unknown None None None None None 6opa S R 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/01/20 Crystal structure of bovine Fab NC-Cow1 in complex with HIV-1 BG505 SOSIP.664, and human Fabs 35022 and PGT128 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Stanfield, R.L., Wilson, I.A. 4.084 X-RAY DIFFRACTION 0.343 0.332 False True unknown IGLV1 Lambda None None None None None 7rxl C D 0 F protein NA circumsporozoite protein IMMUNE SYSTEM 08/23/21 Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum HOMO SAPIENS; PLASMODIUM FALCIPARUM (ISOLATE 3D7) homo sapiens homo sapiens plasmodium falciparum (isolate 3d7) Pholcharee, T., Oyen, D., Wilson, I.A. 1.823 X-RAY DIFFRACTION 0.255 0.207 False True IGHV3 IGLV3 Lambda None None None None None 6uus N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/31/19 CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R. 2.4 ELECTRON MICROSCOPY False True IGHV3 None None None None None 7elx H L 0 C protein NA cytotoxic t-lymphocyte protein 4 APOPTOSIS 04/12/21 The crystal structure of CTLA-4 and Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yu, X.J., Wang, L., Yu, C.F. 2.14 X-RAY DIFFRACTION 0.217 0.177 False True IGHV3 IGKV3 Kappa None None None None None 6ea7 H L 0 B | A | F protein | protein | protein NA | NA | NA envelope glycoprotein | envelope glycoprotein | envelope glycoprotein VIRAL PROTEIN/immune system 08/02/18 Structure of EBOV GPcl in complex with the pan-ebolavirus mAb ADI-15878 ZAIRE EBOLAVIRUS; EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus | zaire ebolavirus | ebola virus West, B.R., Moyer, C.L., King, L.B., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O. 4.25 X-RAY DIFFRACTION 0.324 0.280 False True IGHV3 IGKV1 Kappa None None None None None 1dlf H L 0 IMMUNOGLOBULIN 07/14/98 HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FV FRAGMENT FROM AN ANTI-DANSYL SWITCH VARIANT ANTIBODY IGG2A(S) CRYSTALLIZED AT PH 5.25 MUS MUSCULUS mus musculus mus musculus Nakasako, M., Takahashi, H., Shimada, I., Arata, Y. 1.45 X-RAY DIFFRACTION 0.230 0.183 False False IGHV6 IGKV1 Kappa None None None None None 7lmr NA A 0 B Hapten 9ZX 4-methyl-3-(morpholin-4-ylmethyl)-7-[(2~{S})-2-phenylpropoxy]chromen-2-one IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 63 [4-methyl-3-(morpholinomethyl)-7-(2-phenylpropoxy)-2H-chromen-2-one] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.09 X-RAY DIFFRACTION 0.261 0.202 False True NA IGLV6 Lambda None None None None None 3cvi H L 0 IMMUNE SYSTEM 04/18/08 How TCR-like antibody recognizes MHC-bound peptide MUS MUSCULUS mus musculus mus musculus Mareeva, T., Martinez-Hackert, E., Sykulev, Y. 1.8 X-RAY DIFFRACTION 0.264 0.219 False False IGHV1 IGKV13 Kappa None None None None None 5n2k F E 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 5fcs H h 0 IMMUNE SYSTEM 12/15/15 Diabody HOMO SAPIENS homo sapiens Mosyak, L., Root, A. 2.01 X-RAY DIFFRACTION 0.205 0.176 True True unknown unknown unknown None None None None None 3ojd B A 0 IMMUNE SYSTEM 08/22/10 Anti-Indolicidin monoclonal antibody V2D2 (Fab fragment) MUS MUSCULUS mus musculus mus musculus Lomash, S., Salunke, D.M. 2.0 X-RAY DIFFRACTION 0.236 0.205 False False IGHV9 IGKV12 Kappa None None None None None 6wzg N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 05/13/20 Human secretin receptor Gs complex HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Piper, S.J., Belousoff, M.J., Danev, R. 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4nby C NA 0 A protein cell wall-binding repeat protein IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A2 Bound to Two Molecules of A20.1 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E., Klassen, J.S., Ng, K.K.S. 2.08 X-RAY DIFFRACTION 0.255 0.209 False True IGHV1 None None None None None 4i77 H L 0 Z protein interleukin-13 IMMUNE SYSTEM/CYTOKINE 11/30/12 Lebrikizumab Fab bound to IL-13 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Ultsch, M. 1.9 X-RAY DIFFRACTION 0.219 0.179 False True IGHV2 IGKV3 Kappa None None None None None 4laj H NA 0 J | K protein | peptide NA | NA hiv-1 yu2 gp120 envelope glycoprotein | cd4-mimetic miniprotein m48u1 VIRAL PROTEIN/INHIBITOR 06/20/13 Crystal structure of HIV-1 YU2 envelope gp120 glycoprotein in complex with CD4-mimetic miniprotein, M48U1, and llama single-domain, broadly neutralizing, co-receptor binding site antibody, JM4 HUMAN IMMUNODEFICIENCY VIRUS 1; LLAMA GLAMA; SYNTHETIC CONSTRUCT lama glama human immunodeficiency virus 1 | Acharya, P., Luongo, T.S., Kwong, P.D. 2.14 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 None None None None None 1cfs B A 0 C peptide protein (antigen bound peptide) POLYSPECIFICITY 03/19/99 ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J., Hoehne, W. 2.75 X-RAY DIFFRACTION 0.332 0.232 False False IGHV1 IGKV14 Kappa None None None None None 3tcl H L 0 IMMUNE SYSTEM 08/09/11 Crystal Structure of HIV-1 Neutralizing Antibody CH04 HOMO SAPIENS homo sapiens homo sapiens Louder, R.K., McLellan, J.S., Pancera, M., Yang, Y., Zhang, B., Bonsignori, M., Kwong, P.D. 1.906 X-RAY DIFFRACTION 0.238 0.196 False True IGHV3 IGKV3 Kappa None None None None None 6itp B NA 0 B Hapten HCY (11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE IMMUNE SYSTEM 11/24/18 Crystal structure of cortisol complexed with its nanobody at pH 3.5 CAMELUS BACTRIANUS camelus bactrianus camelus bactrianus Ding, Y., Ding, L.L., Wang, Z.Y., Zhong, P.Y. 1.572 X-RAY DIFFRACTION 0.223 0.195 False True unknown unknown unknown None None None None None 7kmi A B 0 C protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 11/02/20 LY-CoV481 neutralizing antibody against SARS-CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hendle, J., Pustilnik, A., Sauder, J.M., Coleman, K.A., Boyles, J.S., Dickinson, C.D. 1.73 X-RAY DIFFRACTION 0.217 0.186 False True IGHV3 IGKV1 Kappa None None None None None 7rbv h l 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 SARS-CoV-2 Spike in complex with PVI.V6-14 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Altomare, C.G., Bajic, G. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV4 IGKV1 Kappa None None None None None 5i1g H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-53/IGKV3-11 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.3 X-RAY DIFFRACTION 0.383 0.298 False True IGHV3 IGKV3 Kappa None None None None None 6woq A B 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/25/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody HC1AM and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 3.667 X-RAY DIFFRACTION 0.277 0.227 False True IGHV1 IGKV2 Kappa None None None None None 6lxi C D 0 B protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of Z2B3 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/brevigmission/1/1918 h1n1) Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 2.5 X-RAY DIFFRACTION 0.212 0.183 False True IGHV1 IGLV2 Lambda None None None None None 6elj A B 0 IMMUNE SYSTEM 09/29/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 1.9 X-RAY DIFFRACTION 0.223 0.181 False True IGHV4 IGKV1 Kappa None None None None None 1a6v H L 0 H Hapten NPC 4-HYDROXY-3-NITROPHENYLACETYL-EPSILON-AMINOCAPROIC ACID ANION IMMUNOGLOBULIN 03/03/98 B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-3-NITROPHENYL) ACETATE COMPOUND MUS MUSCULUS mus musculus mus musculus mus musculus Simon, T., Henrick, K., Hirshberg, M., Winter, G. 1.8 X-RAY DIFFRACTION unknown 0.296 False True IGHV1 IGLV1 Lambda None None None None None 6lz4 D E 0 F peptide map peptide IMMUNE SYSTEM 05/20/20 Crystal structure of PMab-1 Fv-clasp fragment with its antigen peptide RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus mus musculus Arimori, T., Takagi, J. 2.49 X-RAY DIFFRACTION 0.269 0.245 False True IGHV1 IGKV3 Kappa None None None None None 4mxv F E 0 B protein lymphotoxin-alpha CYTOKINE/IMMUNE SYSTEM 09/26/13 Structure of Lymphotoxin alpha bound to anti-LTa Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, J.P., Hymowitz, S.G. 3.2 X-RAY DIFFRACTION 0.235 0.177 False True IGHV3 IGKV1 Kappa None None None None None 5f89 A B 0 IMMUNE SYSTEM 12/09/15 Structure of the Unliganded Fab from HIV-1 Neutralising Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface HOMO SAPIENS homo sapiens homo sapiens Wibmer, C.K., Gorman, J., Kwong, P.D. 2.7842 X-RAY DIFFRACTION 0.279 0.228 False True IGHV4 IGLV2 Lambda None None None None None 1jnn H L 0 H Hapten EST ESTRADIOL IMMUNE SYSTEM 07/24/01 Crystal Structure of Fab-Estradiol Complexes MUS MUSCULUS mus musculus mus musculus mus musculus Monnet, C., Bettsworth, F., Stura, E.A., Le Du, M.-H., Menez, R., Derrien, L., Zinn-Justin, S., Gilquin, B., Sibai, G., Battail-Poirot, N., Jolivet, M., Menez, A., Arnaud, M., Ducancel, F., Charbonnier, J.B. 3.2 X-RAY DIFFRACTION 0.316 0.211 False False IGHV14 IGKV12 Kappa None None None None None 6e56 H J 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/19/18 Human antibody H2214 in complex with influenza hemagglutinin A/Aichi/2/1968 (X-31) (H3N2) INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus McCarthy, K.R., Harrison, S.C. 2.0 X-RAY DIFFRACTION 0.214 0.188 False True IGHV3 IGKV3 Kappa None None None None None 6ozc C D 0 A carbohydrate MAN ALPHA-D-MANNOSE VIRAL PROTEIN 05/20/20 BG505 SOSIP.664 with 2G12 Fab2 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.79 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 6okn C D 0 E protein tumor necrosis factor receptor superfamily member 4 IMMUNE SYSTEM 04/14/19 OX40R (TNFRSF4) bound to Fab 1A7 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M.H., Boenig, G., Harris, S.F. 3.25 X-RAY DIFFRACTION 0.228 0.192 False True IGHV1 IGKV1 Kappa None None None None None 5vn3 H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/28/17 Cryo-EM model of B41 SOSIP.664 in complex with soluble CD4 (D1-D2) and fragment antigen binding variable domain of 17b HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Pallesen, J., Ward, A.B. 3.7 ELECTRON MICROSCOPY / HOMOLOGY MODEL False True IGHV1 IGKV3 Kappa None None None None None 5kzc H L 0 A protein engineered outer domain of gp120 IMMUNE SYSTEM 07/24/16 Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Julien, J.-P., Jardine, J.G., Diwanji, D., Schief, W.R., Wilson, I.A. 3.25 X-RAY DIFFRACTION 0.274 0.223 False True unknown IGKV3 Kappa None None None None None 4wht E F 0 e peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 5ukb a NA 0 A protein nucleocapsid Viral Protein/RNA/Immune System 01/20/17 VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 ESCHERICHIA COLI; VESICULAR STOMATITIS INDIANA VIRUS; VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 5.473 X-RAY DIFFRACTION 0.338 0.336 False False IGHV1 None None None None None 5fv2 C NA 0 W protein vascular endothelial growth factor 02/02/16 Crystal structure of hVEGF in complex with VH domain antibody HOMO SAPIENS homo sapiens homo sapiens Chung, C., Batuwangala, T. 3.45 X-RAY DIFFRACTION 0.26270 0.21244 False True IGHV3 7.1699999999999995e-12 -15.203792121426005 SPR TBD 3cm9 D O 2 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 1kyo U V 0 P protein ubiquinol-cytochrome c reductase iron-sulfursubunit OXIDOREDUCTASE/ELECTRON TRANSPORT 02/05/02 YEAST CYTOCHROME BC1 COMPLEX WITH BOUND SUBSTRATE CYTOCHROME C MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Lange, C., Hunte, C. 2.97 X-RAY DIFFRACTION 0.268 0.229 False True IGHV3 IGKV10 Kappa None None None None None 6s8d H L 0 A protein envelope glycoprotein VIRAL PROTEIN 07/09/19 Structure of ZEBOV GP in complex with 1T0227 antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus Diskin, R., Cohen-Dvashi, H. 3.49 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 4glr H I 0 A peptide NA phospho-peptide IMMUNE SYSTEM 08/14/12 Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235 GALLUS GALLUS; SYNTHETIC CONSTRUCT gallus gallus gallus gallus homo sapiens Tu, C., Mosyak, L., Bard, J. 1.9 X-RAY DIFFRACTION 0.208 0.179 False True unknown unknown unknown None None None None None 6oz9 H L 0 B | A protein | protein NA | NA envelope glycoprotein | small secreted glycoprotein sgp VIRAL PROTEIN/Immune system 05/15/19 Ebola virus glycoprotein in complex with EBOV-520 Fab EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus | ebola virus Milligan, J.C., Altman, P.X., Hui, S., Hastie, K.M., Gilchuk, P., Crowe, J.E., Saphire, E.O. 3.462 X-RAY DIFFRACTION 0.235 0.199 False True IGHV4 IGKV3 Kappa None None None None None 5lhq B NA 0 A protein urokinase-type plasminogen activator Hydrolase/Antibody 07/12/16 The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 MUS MUSCULUS; VICUGNA PACOS vicugna pacos mus musculus Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A. 2.6 X-RAY DIFFRACTION 0.217 0.178 False True IGHV1 None None None None None 6azz C B 0 A protein pfs25 IMMUNE SYSTEM 09/13/17 Crystal structure of Pfs25 in complex with the transmission blocking antibody 1190 HOMO SAPIENS; PLASMODIUM FALCIPARUM homo sapiens homo sapiens plasmodium falciparum Scally, S.W., McLeod, B., Bosch, A., King, C.R., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.217 0.191 False True IGHV1 IGLV3 Lambda 6.7000000000000004e-09 -11.151229137696946 BLI TBD 1v7m H L 0 V protein thrombopoietin IMMUNE SYSTEM/CYTOKINE 12/18/03 Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R. 2.51 X-RAY DIFFRACTION 0.316 0.228 False True IGHV6 IGKV4 Kappa None None None None None 7n3c H L 0 C protein NA nucleoprotein VIRAL PROTEIN 05/31/21 Crystal Structure of Human Fab S24-202 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 1.82 X-RAY DIFFRACTION 0.210 0.179 False True IGHV5 IGKV3 Kappa None None None None None 5t78 B A 0 F peptide muc1 glycopeptide IMMUNE SYSTEM 09/02/16 Crystal structure of therapeutic mAB AR20.5 in complex with MUC1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Brooks, C.L., Movahedin, M. 2.2 X-RAY DIFFRACTION 0.221 0.194 False True IGHV5 IGKV1 Kappa 4.3e-08 -10.04974711892974 Unknown TBD 7nx9 H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the N501Y mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.4 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGKV1 Kappa None None None None None 7swp H L 0 A protein NA spike protein s1 VIRAL PROTEIN/Immune System 11/20/21 G32Q4 Fab in complex with SARS-CoV-2 Spike 6P (RBD local reconstruction) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Windsor, I.W., Tong, P., Wesemann, D.R., Harrison, S.C. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 1g7j B A 0 C protein lysozyme c HYDROLASE INHIBITOR/HYDROLASE 11/10/00 CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME (HEL) COMPLEXED WITH THE MUTANT ANTI-HEL MONOCLONAL ANTIBODY D1.3 (VLW92H) MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Sundberg, E.J., Urrutia, M., Braden, B.C., Isern, J., Mariuzza, R.A. 1.75 X-RAY DIFFRACTION 0.229 0.197 False True IGHV2 IGKV12 Kappa None None None None None 7lde N M 0 B protein NA glutamate receptor MEMBRANE PROTEIN 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV10 Kappa None None None None None 6ffj C c 0 ANTITUMOR PROTEIN 01/08/18 Anti-tumor antibody 14F7-derived single chain fragment variable (scFv) HOMO SAPIENS homo sapiens Bjerregaard-Andersen, K., Heggelund, J.E., Krengel, U. 2.2 X-RAY DIFFRACTION 0.238 0.184 True True unknown unknown unknown None None None None None 2nz9 D C 0 A protein botulinum neurotoxin type a TOXIN/IMMUNE SYSTEM 11/22/06 Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2 HOMO SAPIENS; CLOSTRIDIUM BOTULINUM clostridium botulinum Stevens, R.C., Arndt, J.W. 3.79 X-RAY DIFFRACTION 0.278 0.224 False False IGHV5 IGKV3 Kappa 6.80e-12 -15.12 Other 23 17173035 3p9w H NA 0 G protein vascular endothelial growth factor a SIGNALING PROTEIN/IMMUNE SYSTEM 10/18/10 Crystal structure of an engineered human autonomous VH Domain in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens Ma, X., Wiesmann, C. 2.41 X-RAY DIFFRACTION 0.233 0.193 False True IGHV3 1.6e-08 -10.635483235413165 SPR TBD 5i9q H L 0 G protein 426c.tm4dv1-3 p120 IMMUNE SYSTEM 02/20/16 Crystal structure of 3BNC55 Fab in complex with 426c.TM4deltaV1-3 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Chen, C., Bjorkman, P.J. 3.0 X-RAY DIFFRACTION 0.270 0.251 False True unknown IGKV1 Kappa None None None None None 6vmk P O 0 Q protein NA fab y49r light chain HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 4y8d C NA 0 A protein cyclin-g-associated kinase TRANSFERASE 02/16/15 Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Chaikuad, A., Heroven, C., Nowak, R., De Jonghe, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC) 2.1 X-RAY DIFFRACTION 0.232 0.192 False False IGHV1 8.9e-09 -10.982997099581803 Unknown TBD 4xnq B A 0 D protein influenza h5 ha head domain vietnam rdt mutations Viral protein/Immune system 01/15/15 Antibody hemagglutinin Complexes INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Spiller, B.W., Winarski, K.L. 2.001 X-RAY DIFFRACTION 0.225 0.191 False True IGHV4 IGLV3 Lambda None None None None None 6nnf H L 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 01/14/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to VRC01 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.762 X-RAY DIFFRACTION 0.298 0.242 False True IGHV4 unknown unknown None None None None None 5drx H L 0 IMMUNE SYSTEM 09/16/15 Crystal structure of the BCR Fab fragment from subset #4 case CLL240 HOMO SAPIENS homo sapiens homo sapiens Minici, C., Degano, M. 2.104 X-RAY DIFFRACTION 0.222 0.194 False True IGHV4 IGKV2 Kappa None None None None None 2fee I L 0 B protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 12/15/05 Structure of the Cl-/H+ exchanger CLC-ec1 from E.Coli in NaBr ESCHERICHIA COLI; HOMO SAPIENS homo sapiens homo sapiens escherichia coli Accardi, A., Walden, M.P., Nguitragool, W., Jayaram, H., Williams, C., Miller, C. 3.2 X-RAY DIFFRACTION 0.293 0.251 False True IGHV3 IGKV6D Kappa None None None None None 3qeg H L 0 IMMUNE SYSTEM 01/20/11 Crystal structure of human N12-i2 Fab, an ADCC and neutralizing anti-HIV-1 Env antibody HOMO SAPIENS homo sapiens homo sapiens Guan, Y., DeVico, A.L., Lewis, G.K., Pazgier, M. 1.95 X-RAY DIFFRACTION 0.236 0.203 False False IGHV1 IGKV3 Kappa None None None None None 5o04 F NA 0 A protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 norovirus protruding domain in complex with Nanobody Nano-26 and Nano-85 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, A.D. 2.3 X-RAY DIFFRACTION 0.242 0.212 False True IGHV1 None None None None None 6u0n P Q 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 08/14/19 Asymmetrically open conformational state (Class II) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 6cdi M N 0 C protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 7ldd N M 0 B protein NA glutamate receptor MEMBRANE PROTEIN/IMMUNE SYSTEM 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV10 Kappa None None None None None 5en2 A B 0 C protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 11/09/15 Molecular basis for antibody-mediated neutralization of New World hemorrhagic fever mammarenaviruses JUNIN MAMMARENAVIRUS; MUS MUSCULUS mus musculus mus musculus junin mammarenavirus Mahmutovic, S., Clark, L., Levis, S., Briggiler, A., Enria, D., Harrison, S.C., Abraham, J. 1.821 X-RAY DIFFRACTION 0.224 0.181 False True IGHV1 IGKV6 Kappa None None None None None 7dr4 A B 0 J protein NA interleukin-2 IMMUNE SYSTEM 12/25/20 Complex of anti-human IL-2 antibody and human IL-2 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Kim, M.S., Kim, J.E. 2.49 X-RAY DIFFRACTION 0.258 0.195 False True IGHV1 IGKV17 Kappa None None None None None 2imn NA A 0 IMMUNOGLOBULIN 03/30/92 REFINED CRYSTAL STRUCTURE OF A RECOMBINANT IMMUNOGLOBULIN DOMAIN AND A COMPLEMENTARITY-DETERMINING REGION 1-GRAFTED MUTANT MUS MUSCULUS mus musculus Steipe, B., Huber, R. 1.97 X-RAY DIFFRACTION unknown 0.149 False True unknown unknown unknown None None None None None 7s0c M N 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-017 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7cj2 K L 0 B protein NA chitinase 3-like 1 (cartilage glycoprotein-39), isoformcra_a IMMUNE SYSTEM 07/09/20 Crystal structure of the Fab antibody complexed with human YKL-40 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Choi, S., Na, J.H., Lee, S.J., Woo, J.R., Kim, D.Y., Hong, J.T., Lee, W.K. 2.7 X-RAY DIFFRACTION 0.269 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6cdi h l 0 c protein unknown VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False False IGHV1 IGKV1 Kappa None None None None None 6u3i H L 0 A protein proprotein convertase subtilisin/kexin type 9 HYDROLASE/HYDROLASE INHIBITOR/IMMUNE SYSTEM 08/21/19 Design of organo-peptides as bipartite PCSK9 antagonists HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Ultsch, M.H., Kirchhofer, D. 2.9 X-RAY DIFFRACTION 0.217 0.179 False True IGHV1 IGKV6 Kappa None None None None None 3bdy H L 0 V protein vascular endothelial growth factor a HORMONE 11/15/07 Dual specific bH1 Fab in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bostrom, J.M., Wiesmann, C., Appleton, B.A. 2.6 X-RAY DIFFRACTION 0.252 0.194 False True IGHV3 IGKV1 Kappa 3.00e-07 -8.89 SPR 19299620 7e8c T V 0 B protein NA spike glycoprotein VIRAL PROTEIN 03/01/21 SARS-CoV-2 S-6P in complex with 9 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Du, S., Xiao, J., Zhang, Z. 3.16 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6u12 B NA 0 A protein inlb IMMUNE SYSTEM 08/15/19 VHH R303 C33A/C102A in complex withthe LRR domain of InlB LISTERIA MONOCYTOGENES; CAMELUS DROMEDARIUS camelus dromedarius listeria monocytogenes Mendoza, M.N., Jian, M., Toride King, M., Brooks, C.L. 1.56 X-RAY DIFFRACTION 0.199 0.175 False True IGHV1 None None None None None 6v80 J NA 0 F | H protein | protein NA | NA antigen-presenting glycoprotein cd1d | t cell receptor alpha variable 10, nkt tcr alpha chainfusion IMMUNE SYSTEM 12/10/19 Crystal structure of human CD1d presenting alpha-Galactosylceramide in complex with NKT12 TCR and VHH nanobody 1D12 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Shahine, A., Rossjohn, J. 3.53 X-RAY DIFFRACTION 0.254 0.195 False True IGHV1 NA NA None None None None None 3lh2 H L 0 S protein 4e10_1vi7a_s0_002_n (t88) IMMUNE SYSTEM 01/21/10 Crystal structure of HIV epitope-scaffold 4E10_1VI7A_S0_002_N 4E10 Fv complex ARTIFICIAL GENE; HOMO SAPIENS homo sapiens homo sapiens artificial gene Holmes, M.A. 2.65 X-RAY DIFFRACTION 0.270 0.222 False True IGHV1 IGKV3 Kappa 5.60e-09 -11.25 SPR 20826338 5grz A a 0 IMMUNE SYSTEM 08/13/16 Crystal structure of disulfide-bonded diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.7 X-RAY DIFFRACTION 0.301 0.246 True True unknown unknown unknown None None None None None 7klc D C 0 A protein NA hiv-1 clade a bg505 gp120,hiv-1 clade a bg505 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 10/29/20 Crystal structure of M4H2K1 Fab bound to HIV-1 BG505 gp120 core and to 17b Fab MUS MUSCULUS; HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 4.3 X-RAY DIFFRACTION 0.334 0.302 False True IGHV1 IGKV3 Kappa None None None None None 4hii B A 0 A carbohydrate GAL polysaccharide IMMUNE SYSTEM 10/11/12 Anti-Streptococcus pneumoniae 23F Fab 023.102 with bound rhamnose-galactose HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S, Thomson, C.A., Schrader, J.W., Pai, E.F. 2.3 X-RAY DIFFRACTION 0.256 0.243 False True IGHV3 IGKV3 Kappa None None None None None 6glx H L 0 A protein galectin-10 SUGAR BINDING PROTEIN 05/23/18 Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 4E8 HOMO SAPIENS; LAMA GLAMA lama glama lama glama homo sapiens Verstraete, K., Verschueren, K., Savvides, S.N. 3.396 X-RAY DIFFRACTION 0.360 0.303 False True IGHV4 IGLV3 Lambda None None None None None 4eiz D NA 0 A protein dihydrofolate reductase OXIDOREDUCTASE/IMMUNE SYSTEM 04/06/12 Structure of Nb113 bound to apoDHFR ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Oyen, D., Srinivasan, V. 2.2 X-RAY DIFFRACTION 0.224 0.171 False True IGHV1 3.0000000000000004e-09 -11.627286953008985 SPR TBD 3idn B A 0 C peptide gp41 mper peptide analog IMMUNE SYSTEM 07/21/09 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 Fab' fragment in complex with gp41 Peptide analog ELD(Paf)WAS HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.-P., Bryson, S., Pai, E.F. 2.25 X-RAY DIFFRACTION 0.238 0.220 False False IGHV2 IGKV1 Kappa None None None None None 7wui N NA 0 A protein NA mini-gs MEMBRANE PROTEIN 02/08/22 Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 HOMO SAPIENS; LAMA GLAMA; MUS MUSCULUS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT lama glama homo sapiens Guo, S.C., He, Q.T., Xiao, P., Sun, J.P., Yu, X. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 1uz6 F E 0 IMMUNE SYSTEM 03/05/04 anti-Lewis X Fab fragment uncomplexed MUS MUSCULUS mus musculus mus musculus Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P. 2.05 X-RAY DIFFRACTION 0.244 0.198 False False IGHV4 IGKV2 Kappa None None None None None 1xgy I M 0 Q peptide rhodopsin epitope mimetic peptide immune system 09/17/04 Crystal Structure of Anti-Meta I Rhodopsin Fab Fragment K42-41L MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Piscitelli, C.L., Angel, T.E., Bailey, B.W., Lawerence, C.M. 2.71 X-RAY DIFFRACTION 0.272 0.233 False False IGHV1 IGKV2 Kappa None None None None None 7soa H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S NTD B.1.617.2 delta variant + S2L20 Local Refinement HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5xqy NA C 0 IMMUNE SYSTEM 06/07/17 Structure of monomeric mutant of REI immunoglobulin light chain variable domain crystallized at pH 8 HOMO SAPIENS homo sapiens Mine, S., Nakamura, T., Uegaki, K., Hamada, D. 2.9 X-RAY DIFFRACTION 0.285 0.231 False True IGKV1 Kappa None None None None None 3fku Y y 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/17/08 Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens influenza a virus | influenza a virus Hwang, W.C., Santelli, E., Stec, B., Wei, G., Cadwell, G., Bankston, L.A., Sui, J., Perez, S., Aird, D., Chen, L.M., Ali, M., Murakami, A., Yammanuru, A., Han, T., Cox, N., Donis, R.O., Liddington, R.C., Marasco, W.A. 3.2 X-RAY DIFFRACTION 0.286 0.232 True True unknown unknown unknown 1.30E-10 -13.48 SPR 25 19234466 1f4y H L 0 H Hapten MGU 2-O-[2-O-METHYL-4-[2,4-DIHYDROXY-BUTYRAMIDO]-4,6-DIDEOXY-]-ALPHA-D-MANNOPYRANOSYL-[1-O-METHYL-4-[2,4-DIHYDROXY-BUTYRAMIDO]-4,6-DIDEOXY]-ALPHA-D-MANNOPYRANOSE IMMUNE SYSTEM 06/10/00 CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN MUS MUSCULUS mus musculus mus musculus mus musculus Alzari, P.M., Souchon, H. 2.8 X-RAY DIFFRACTION 0.352 0.226 False False IGHV5 IGLV1 Lambda 8.33e-07 -8.29 Other 10880560 7bu6 B NA 0 A protein NA endolysin,endolysin,endolysin,beta-1 adrenergic receptorchimera MEMBRANE PROTEIN 04/04/20 Structure of human beta1 adrenergic receptor bound to norepinephrine and nanobody 6B9 ENTEROBACTERIA PHAGE T4; HOMO SAPIENS; CAMELIDAE MIXED LIBRARY camelidae mixed library enterobacteria phage t4, homo sapiens Xu, X., Kaindl, J., Clark, M., Hubner, H., Hirata, K., Sunahara, R., Gmeiner, P., Kobilka, B.K., Liu, X. 2.7 X-RAY DIFFRACTION 0.258 0.232 False True IGHV1 NA NA None None None None None 5ukn H L 0 IMMUNE SYSTEM 01/23/17 Structure of unliganded anti-gp120 CD4bs antibody DH522UCA Fab MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I. 1.75 X-RAY DIFFRACTION 0.202 0.167 False True IGHV4 IGLV2 Lambda None None None None None 3cvh Q R 0 M | O protein | peptide NA | NA h-2 class i histocompatibility antigen, k-b alpha chain | ovalbumin IMMUNE SYSTEM 04/18/08 How TCR-like antibody recognizes MHC-bound peptide MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus mus musculus | gallus gallus Mareeva, T., Martinez-Hackert, E., Sykulev, Y. 2.9 X-RAY DIFFRACTION 0.296 0.219 False False IGHV1 IGKV13 Kappa None None None None None 4m8q H L 0 C protein 4e10 epitope scaffold t117 IMMUNE SYSTEM 08/13/13 Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Finton, K.A.K. 2.89 X-RAY DIFFRACTION 0.302 0.261 False True IGHV1 IGKV3 Kappa 3.96e-09 -11.462794680024446 SPR TBD 4fab H L 0 H Hapten FDS FLUORESCIN IMMUNOGLOBULIN 04/10/89 THREE-DIMENSIONAL STRUCTURE OF A FLUORESCEIN-FAB COMPLEX CRYSTALLIZED IN 2-METHYL-2,4-PENTANEDIOL MUS MUSCULUS mus musculus mus musculus mus musculus Herron, J.N., He, X., Mason, M.L., Vossjunior, E.W., Edmundson, A.B. 2.7 X-RAY DIFFRACTION unknown unknown False True IGHV6 IGKV1 Kappa 8.33e-09 -11.02 Other 2508085 6udj Q B 0 G protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 2.5 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 6mg5 NA B 0 B Hapten 6ZW 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one IMMUNE SYSTEM 04/10/19 Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1 HOMO SAPIENS homo sapiens homo sapiens Morgan, G.J., Yan, N.L., Mortenson, D.E., Stanfield, R.L., Wilson, I.A., Kelly, J.W. 1.8 X-RAY DIFFRACTION 0.263 0.204 False True IGLV6 Lambda None None None None None 4f58 K O 0 IMMUNE SYSTEM 05/12/12 Fab structure of a neutralizing antibody L3 from an early subtype A HIV-1 infected patient HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.488 X-RAY DIFFRACTION 0.256 0.208 False False IGHV3 IGLV2 Lambda None None None None None 4gay A B 0 IMMUNE SYSTEM 07/26/12 Structure of the broadly neutralizing antibody AP33 MUS MUSCULUS mus musculus mus musculus Potter, J.A., Owsianka, A., Jeffery, N., Matthews, D., Keck, Z., Lau, P., Foung, S.K.H., Taylor, G.L., Patel, A.H. 2.65 X-RAY DIFFRACTION 0.320 0.243 False False IGHV3 IGKV3 Kappa None None None None None 6gkd S NA 0 R protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 7l6m h g 0 NA NA NA NA IMMUNE SYSTEM 12/23/20 Cryo-EM structure of DH898.1 Fab-dimer from local refinement of the Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer MACACA MULATTA macaca mulatta macaca mulatta Manne, K., Edwards, R.J., Acharya, P. 4.7 ELECTRON MICROSCOPY NA NA False False unknown IGKV2 Kappa None None None None None 7p5v H NA 0 B protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3qct H L 0 IMMUNE SYSTEM 01/17/11 Crystal structure of the humanized apo LT3015 anti-lysophosphatidic acid antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Fleming, J.K., Wojciak, J.M., Campbell, M.-A., Huxford, T. 2.1493 X-RAY DIFFRACTION 0.287 0.238 False True IGHV5 IGKV2D Kappa None None None None None 7r73 A NA 0 G protein NA glycoprotein 120 IMMUNE SYSTEM 06/24/21 Crystal structure of llama VHH antibody D7 in complex with HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA GLAMA lama glama human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 1.76 X-RAY DIFFRACTION 0.215 0.179 False True IGHV1 NA NA None None None None None 6h16 B NA 0 A protein low-density lipoprotein receptor-related protein 6 SIGNALING PROTEIN 07/11/18 Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-D07 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Gros, P., van Scherpenzeel, R.C. 2.9 X-RAY DIFFRACTION 0.252 0.211 False True IGHV1 None None None None None 6cxl M K 0 M carbohydrate BMA polysaccharide IMMUNE SYSTEM 04/03/18 anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Stanfield, R.L., Wilson, I.A. 3.586 X-RAY DIFFRACTION 0.248 0.219 False True unknown IGKV1 Kappa None None None None None 7qnd L NA 0 C protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6ujb E F 0 B | A protein | protein NA | NA integrin beta-8 | integrin alpha-v SIGNALING PROTEIN/IMMUNE SYSTEM 10/02/19 Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Campbell, M.G., Cormier, A., Cheng, Y., Nishimura, S.L. 3.51 ELECTRON MICROSCOPY False True IGHV9 IGKV8 Kappa None None None None None 6wgk C D 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.62 X-RAY DIFFRACTION 0.236 0.210 False True IGHV3 IGKV2 Kappa None None None None None 5x8l H M 0 C protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 03/03/17 PD-L1 in complex with atezolizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, H.T. 3.1 X-RAY DIFFRACTION 0.256 0.208 False True IGHV3 IGKV1 Kappa None None None None None 6nf5 O P 0 J protein hiv-1 env bg505 md64 n332-gt5 sosip gp120 VIRAL PROTEIN/immune system 12/18/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Steichen, J.M., Schief, W.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 2xt1 B NA 0 A protein gag polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/03/10 Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 231) in complex with a camelid VHH. HUMAN IMMUNODEFICIENCY VIRUS 1; VICUGNA PACOS vicugna pacos human immunodeficiency virus 1 Igonet, S., Vaney, M.-C., Bartonova, V., Helma, J., Rothbauer, U., Leonhardt, H., Stura, E., Krausslich, H.-G., Rey, F.A. 1.32 X-RAY DIFFRACTION 0.1835 0.1607 False True IGHV1 None None None None None 6xsw D E 0 F protein NA neurogenic locus notch homolog protein 3 SIGNALING PROTEIN/Immune System 07/16/20 Structure of the Notch3 NRR in complex with an antibody Fab Fragment RATTUS NORVEGICUS; HOMO SAPIENS rattus norvegicus rattus norvegicus homo sapiens Bard, J. 2.98 X-RAY DIFFRACTION 0.256 0.233 False True IGHV3 IGKV1 Kappa None None None None None 6vo1 I K 0 D protein NA envelope glycoprotein gp120 VIRAL PROTEIN 01/29/20 BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.88 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 5d93 C B 0 A protein sulfhydryl oxidase 1 OXIDOREDUCTASE 08/18/15 Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from a Mouse QSOX1-Specific Antibody MUS MUSCULUS mus musculus mus musculus mus musculus Grossman, I., Fass, D. 2.201 X-RAY DIFFRACTION 0.236 0.174 False True IGHV1 IGKV4 Kappa None None None None None 6bit I K 0 H protein tyrosine-protein phosphatase non-receptor type substrate 1 IMMUNE SYSTEM 11/03/17 SIRPalpha antibody complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Ring, N.G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J.P., George, B.M., Lietzenmayer, M., McKenna, K.M., Naik, T.J., McCarty, A., Zheng, Y., Ring, A.M., Flavell, R.A., Weissman, I.L. 2.191 X-RAY DIFFRACTION 0.240 0.210 False False IGHV14 IGKV4 Kappa 2.6e-09 -11.712071867460315 SPR TBD 6nyq H L 0 C protein glycosylated lysosomal membrane protein IMMUNE SYSTEM 02/12/19 Crystal structure of glycosylated lysosomal membrane protein (GLMP) luminal domain bound to a Fab fragment MUS MUSCULUS mus musculus mus musculus mus musculus Huang, C.S., Boenig, G., Hymowitz, S.G. 1.85 X-RAY DIFFRACTION 0.204 0.164 False True IGHV1 IGKV12 Kappa None None None None None 1r70 B A 0 IMMUNE SYSTEM 10/17/03 Model of human IgA2 determined by solution scattering, curve fitting and homology modelling HOMO SAPIENS homo sapiens homo sapiens Furtado, P.B., Whitty, P.W., Robertson, A., Eaton, J.T., Almogren, A., Kerr, M.A., Woof, J.M., Perkins, S.J. 30.0 SOLUTION SCATTERING / HOMOLOGY MODEL False True IGHV1 IGKV1 Kappa None None None None None 1vhp A NA 4 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4k07 NA H 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 6amm H L 0 IMMUNE SYSTEM 08/10/17 CAT192 Fab Insertion Mutant H0/L1 HOMO SAPIENS homo sapiens homo sapiens Lord, D.M., Wei, R.R. 2.8 X-RAY DIFFRACTION 0.303 0.247 False True IGHV3 IGKV1 Kappa None None None None None 6ot1 m n 0 G protein bg505 gp120 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False False IGHV4 unknown unknown None None None None None 4r7d E F 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 6u02 K I 0 J protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/13/19 CryoEM-derived model of NA-63 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.05 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 1fe8 I M 0 B protein von willebrand factor IMMUNE SYSTEM 07/21/00 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Bouma, B., Huizinga, E.G., Schiphorst, M.E., Sixma, J.J., Kroon, J., Gros, P. 2.03 X-RAY DIFFRACTION 0.264 0.227 False False IGHV2 IGKV10 Kappa 2e-06 -7.7747861441417445 Unknown TBD 7lde L l 0 A protein NA glutamate receptor 1 MEMBRANE PROTEIN 01/13/21 native AMPA receptor MUS MUSCULUS mus musculus mus musculus Yu, J., Rao, P., Gouaux, E. 3.9 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6xq2 C B 0 A protein NA hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 07/09/20 Human antibody S8V2-37 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2) INFLUENZA A VIRUS (A/TEXAS/50/2012(H3N2)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/texas/50/2012(h3n2)) McCarthy, K.R., Harrison, S.C. 3.002 X-RAY DIFFRACTION 0.290 0.247 False True IGHV3 IGKV1 Kappa None None None None None 6bhz I M 0 IMMUNE SYSTEM 10/31/17 Trastuzumab Fab D185A (Light Chain) Mutant. HOMO SAPIENS homo sapiens homo sapiens DiDonato, M., Spraggon, G. 1.75 X-RAY DIFFRACTION 0.191 0.168 False True IGHV3 IGKV1 Kappa None None None None None 2rcj J K 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 7z1b B NA 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 02/24/22 Nanobody H11-A10 and F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Mikolajek, H., Naismith, J.H. 2.3 X-RAY DIFFRACTION 0.243 0.198 False True IGHV1 NA NA None None None None None 4ckd K O 0 B protein beta-galactosidase HYDROLASE/IMMUNE SYSTEM 01/03/14 Model of complex between the E.coli enzyme beta-galactosidase and four single chain Fv antibody domains scFv13R4. MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Vinothkumar, K.R., McMullan, G., Henderson, R. 13.0 ELECTRON MICROSCOPY False True IGHV3 IGKV5 Kappa None None None None None 7bb6 B NA 0 C | E protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(s) subunit alphaisoforms short MEMBRANE PROTEIN 12/17/20 AVP-V2R-Galphas-beta1-gamma2-Nb35 (L state) HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Bous, J., Mouillac, B., Bron, P., Granier, S. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6nnf D E 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 01/14/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to VRC01 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.762 X-RAY DIFFRACTION 0.298 0.242 False True unknown unknown unknown None None None None None 4y7m A NA 0 C protein type vi secretion protein icmf MEMBRANE PROTEIN 02/15/15 T6SS protein TssM C-terminal domain (835-1129) from EAEC LAMA GLAMA; ESCHERICHIA COLI 2-156-04_S3_C3 lama glama escherichia coli 2-156-04_s3_c3 Nguyen, V.S., Spinelli, S., Durand, E., Roussel, A., Cambillau, C. 1.92 X-RAY DIFFRACTION 0.211 0.183 False True IGHV1 None None None None None 3f7v A B 0 C protein voltage-gated potassium channel membrane protein/metal transport 11/10/08 KcsA Potassium channel in the open-inactivated state with 23 A opening at T112 STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E. 3.2 X-RAY DIFFRACTION 0.276 0.259 False False IGHV1 IGKV5 Kappa None None None None None 1oay NA M 0 IMMUNE SYSTEM 01/21/03 Antibody multispecificity mediated by conformational diversity RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.66 X-RAY DIFFRACTION 0.280 0.258 False True unknown unknown unknown 1.20e-06 Other 20 12610298 2hkh H L 0 immune system 07/04/06 Crystal structure of the Fab M75 MUS MUSCULUS mus musculus mus musculus Kral, V., Mader, P., Stouracova, R., Fabry, M., Sedlacek, J., Brynda, J. 2.1 X-RAY DIFFRACTION 0.273 0.219 False False IGHV10 IGKV1 Kappa None None None None None 4m7z H L 0 IMMUNE SYSTEM 08/12/13 Unliganded 1 crystal structure of S25-26 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V., Muller-Loennies, S., Saldova, R., Muniyappa, M., Brade, L., Rudd, P.M., Harvey, D.J., Kosma, P., Brade, H. 2.75 X-RAY DIFFRACTION 0.238 0.216 False False IGHV2 IGKV1 Kappa None None None None None 5zuf E D 0 C | A protein | protein NA | NA vp3 | capsid protein vp1 VIRUS LIKE PARTICLE 05/07/18 Fit R10 Fab coordinates into the cryo-EM of EV71 in complex with A9 ENTEROVIRUS A71; MUS MUSCULOIDES mus musculoides mus musculoides enterovirus a71 | enterovirus a71 Wang, X., Zhu, L., Wang, N. 6.8 ELECTRON MICROSCOPY False True IGHV5 IGKV4 Kappa None None None None None 3sgd H L 0 IMMUNE SYSTEM 06/14/11 Crystal structure of the mouse mAb 17.2 MUS MUSCULUS mus musculus mus musculus Pizarro, J.C., Boulot, G., Hontebeyrie, M., Bentley, G.A. 2.31 X-RAY DIFFRACTION 0.235 0.172 False True IGHV10 IGKV1 Kappa None None None None None 3ivk A B 0 C nucleic-acid class i ligase product immune system / RNA 09/01/09 Crystal Structure of the Catalytic Core of an RNA Polymerase Ribozyme Complexed with an Antigen Binding Antibody Fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Koldobskaya, Y., Duguid, E.M., Shechner, D.M., Koide, S., Kossiakoff, A.A., Bartel, D.P., Piccirilli, J.A. 3.1 X-RAY DIFFRACTION 0.225 0.207 False True IGHV5 IGKV15 Kappa None None None None None 5kem B C 0 A protein ebola secreted glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91 HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 5.5 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5nml C NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 4d9q E D 0 B protein factor d HYDROLASE/IMMUNE SYSTEM 01/11/12 Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens macaca mulatta Murray, J.M., Wiesmann, C. 2.28 X-RAY DIFFRACTION 0.230 0.189 False True IGHV7 IGKV1 Kappa 3e-11 -14.355775131829494 SPR TBD 5nbd C NA 0 B | A protein | protein NA | NA wlab protein | wlab protein TRANSPORT PROTEIN 03/01/17 PglK flippase in complex with inhibitory nanobody LAMA GLAMA; CAMPYLOBACTER JEJUNI lama glama campylobacter jejuni | campylobacter jejuni Perez, C., Pardon, E., Steyaert, J., Locher, K.P. 3.9 X-RAY DIFFRACTION 0.335 0.311 False True IGHV3 None None None None None 5i8h E F 0 B protein bg505 sosip.664 gp41 IMMUNE SYSTEM 02/18/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Zhou, T., Kwong, P.D. 4.301 X-RAY DIFFRACTION 0.309 0.281 False True IGHV1 IGKV1 Kappa None None None None None 5jw4 M N 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment in Complex with H5 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 3.7 X-RAY DIFFRACTION 0.285 0.274 False True IGHV6 IGKV1 Kappa None None None None None 7dd2 E H 0 K | D protein | protein NA | NA sars-cov2-s protein | sars-cov2-s protein VIRAL PROTEIN 10/27/20 S-3C1-F2 structure, two RBDs are up and one RBD is down, the two up RBD bind with a 3C1 fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 5c7k E F 0 C | D protein | protein NA | NA envelope glycoprotein gp120 | envelope glycoprotein gp41 IMMUNE SYSTEM 06/24/15 Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Kong, L., Stanfield, R.L., Wilson, I.A. 4.6019 X-RAY DIFFRACTION 0.295 0.289 False True unknown IGKV1 Kappa None None None None None 5ken J I 0 E protein ebola surface glycoprotein, gp1 VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 HOMO SAPIENS; ZAIRE EBOLAVIRUS (STRAIN MAYINGA-76); ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 4.3 ELECTRON MICROSCOPY False True IGHV8 IGKV6 Kappa None None None None None 7rmi N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short, with certain residues mutated to match guanine nucleotide-binding protein g(q) subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/MEMBRANE PROTEIN 07/27/21 SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70 HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Harris, J.A., Faust, B., Gondin, A.B., Daemgen, M.A., Suomivuori, C.M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D., Manglik, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5dsc A B 0 Q peptide peptide IMMUNE SYSTEM 09/17/15 Context-independent anti-hypusine antibody FabHpu24.B in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Zhai, Q., Carter, P.J. 2.4 X-RAY DIFFRACTION 0.248 0.207 False True IGHV1 IGKV1 Kappa None None None None None 6arp B A 0 IMMUNE SYSTEM 08/23/17 Structure of a mutant Cetuximab Fab fragment HOMO SAPIENS homo sapiens homo sapiens Christie, M., Christ, D. 1.7 X-RAY DIFFRACTION 0.197 0.172 False True IGHV2 IGKV5 Kappa None None None None None 6mhg J U 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 5tsj 2 NA 0 G | I protein | protein NA | NA v-type atp synthase subunit e | v-type atpase subunit g membrane protein, hydrolase 10/29/16 Thermus thermophilus V/A-ATPase bound to VH dAbs HOMO SAPIENS; THERMUS THERMOPHILUS (STRAIN HB8 / ATCC 27634 / DSM 579) homo sapiens thermus thermophilus (strain hb8 / atcc 27634 /dsm 579) | thermus thermophilus (strain hb8 / atcc 27634 /dsm 579) Davies, R.B., Smits, C., Wong, A.S.W., Stock, D., Sandin, S., Stewart, A.G. 8.7 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 2hh0 H L 0 P peptide prion protein IMMUNE SYSTEM 06/27/06 Structure of an Anti-PrP Fab, P-Clone, in Complex with its Cognate Bovine Peptide Epitope. MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Kanyo, Z.K. 2.85 X-RAY DIFFRACTION 0.282 0.222 True True IGHV14 IGKV9 Kappa None None None None None 7eb2 N n 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 03/08/21 Cryo-EM structure of human GABA(B) receptor-Gi protein complex HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Shen, C., Mao, C., Xu, C., Jin, N., Zhang, H., Shen, D., Shen, Q., Wang, X., Hou, T., Rondard, P., Chen, Z., Pin, J., Zhang, Y., Liu, J. 3.5 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7m7f E F 0 B protein NA eryai,6-deoxyerythronolide-b synthase erya3, modules 5 and6 chimera BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 3j2x B A 0 IMMUNE SYSTEM 01/28/13 Electron Cryo-microscopy of Chikungunya VLP in complex with neutralizing antibody Fab m242 MUS MUSCULUS mus musculus mus musculus Sun, S., Xiang, Y., Rossmann, M.G. 15.6 ELECTRON MICROSCOPY False False IGHV1 IGKV3 Kappa None None None None None 1dzb B b 0 Y protein turkey egg-white lysozyme c IMMUNE SYSTEM 02/23/00 Crystal structure of phage library-derived single-chain Fv fragment 1F9 in complex with turkey egg-white lysozyme MUS MUSCULUS; MELEAGRIS GALLOPAVO mus musculus meleagris gallopavo Ay, J., Keitel, T., Kuettner, G., Wessner, H., Scholz, C., Hahn, M., Hoehne, W. 2.0 X-RAY DIFFRACTION 0.306 0.225 True True unknown unknown unknown 5.20e-07 -8.57 Other 25 10926506 6pe7 H L 0 IMMUNE SYSTEM 06/20/19 Crystal Structure of ABBV-323 FAB HOMO SAPIENS homo sapiens homo sapiens Argiriadi, M.A. 1.74 X-RAY DIFFRACTION 0.230 0.196 False True IGHV3 IGKV4 Kappa None None None None None 6avu H L 0 B | A protein | protein NA | NA integrin beta-3 | integrin alpha-v SIGNALING PROTEIN 09/04/17 Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D. 35 ELECTRON MICROSCOPY False True IGHV5 IGKV5 Kappa None None None None None 5vn8 H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/28/17 Cryo-EM model of B41 SOSIP.664 in complex with fragment antigen binding variable domain of b12 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Pallesen, J., Ward, A.B., Cottrell, C.A. 3.6 ELECTRON MICROSCOPY / HOMOLOGY MODEL False True IGHV1 IGKV3 Kappa None None None None None 6pzy C D 0 A protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-73 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.17 ELECTRON MICROSCOPY False True IGHV4 IGLV1 Lambda None None None None None 7mf1 H L 0 A protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 04/08/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 47D1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 2.092 X-RAY DIFFRACTION 0.250 0.207 False True IGHV1 IGLV2 Lambda None None None None None 6tcp D C 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.5 X-RAY DIFFRACTION 0.239 0.212 False True IGHV3 IGKV1 Kappa None None None None None 5w3m E G 0 B | A | C protein | protein | protein NA | NA | NA viral protein 3 | viral protein 1 | viral protein 2 VIRUS/IMMUNE SYSTEM 06/08/17 CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:1, full particle) MUS MUSCULUS; HUMAN RHINOVIRUS 14 mus musculus mus musculus human rhinovirus 14 | human rhinovirus 14 | human rhinovirus 14 Liu, Y., Dong, Y., Rossmann, M.G. 2.26 ELECTRON MICROSCOPY False False IGHV2 IGKV12 Kappa None None None None None 6umx h l 0 B protein growth/differentiation factor 8 SIGNALING PROTEIN/IMMUNE SYSTEM 10/10/19 Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Dagbay, K.B., Treece, E., Streich Jr., F.C., Jackson, J.W., Faucette, R.R., Nikiforov, A., Lin, S.C., Bostion, C.J., Nicholls, S.B., Capili, A.D., Carven, G.J. 2.79 X-RAY DIFFRACTION 0.264 0.217 False False IGHV3 IGLV1 Lambda None None None None None 1nfd F E 0 B protein n15 alpha-beta t-cell receptor COMPLEX (IMMUNORECEPTOR/IMMUNOGLOBULIN) 08/04/97 AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY MUS MUSCULUS mus musculus mus musculus mus musculus Wang, J.-H., Lim, K., Smolyar, A., Teng, M.-K., Sacchittini, J., Reinherz, E.L. 2.8 X-RAY DIFFRACTION 0.309 0.243 False True IGHV6 IGKV10 Kappa None None None None None 5cey D C 0 IMMUNE SYSTEM 07/07/15 Crystal Structure of Fab 9H+3L, a putative precursor of the PGT121 family of potent HIV-1 antibodies HOMO SAPIENS homo sapiens homo sapiens Wilson, I.A., Garces, F. 2.387 X-RAY DIFFRACTION 0.273 0.224 False True IGHV4 unknown unknown None None None None None 2kqm NA B 15 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5w2b H L 0 A protein nucleoprotein viral protein/immune system 06/06/17 Crystal structure of C-terminal domain of Ebola (Reston) nucleoprotein in complex with Fab fragment HOMO SAPIENS; RESTON EBOLAVIRUS homo sapiens homo sapiens reston ebolavirus Radwanska, M.J., Derewenda, U., Kossiakoff, A.A., Derewenda, Z.S. 2.25 X-RAY DIFFRACTION 0.254 0.198 False True IGHV3 IGKV1 Kappa None None None None None 7k7i P Q 0 D protein NA putative pertussis-like toxin subunit TOXIN 09/22/20 Density-fitted Model Structure of Antibody Variable Domains of TyTx4 in Complex with PltB pentamer of Typhoid Toxin SALMONELLA TYPHI; MUS MUSCULUS mus musculus mus musculus salmonella typhi Nguyen, T., Feathers, J.R., Fromme, J.C., Song, J. 3.13 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV5 Kappa None None None None None 2kh2 B b 3 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6jri A NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 2kh2 B b 11 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 6j14 A B 0 G protein programmed cell death protein 1 IMMUNE SYSTEM 12/27/18 Complex structure of GY-14 and PD-1 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Chen, D., Tan, S., Whang, H., Zhang, H., Chai, Y., Qi, J., Yan, J., Gao, G.F. 1.4 X-RAY DIFFRACTION 0.215 0.188 False True IGHV1 IGKV1 Kappa None None None None None 6bzw G H 0 L peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody AP33 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 2.2 X-RAY DIFFRACTION 0.231 0.192 False True IGHV3 IGKV3 Kappa None None None None None 5gru L l 0 A protein maltose-binding periplasmic protein IMMUNE SYSTEM 08/12/16 Structure of mono-specific diabody ESCHERICHIA COLI; MUS MUSCULUS; HOMO SAPIENS mus musculus escherichia coli Kim, J.H., Song, D.H., Youn, S.J., Cho, G., Lee, H., Lee, J.O. 1.955 X-RAY DIFFRACTION 0.237 0.197 True True unknown unknown unknown None None None None None 4nbz B NA 0 A protein tcda IMMUNE SYSTEM 10/23/13 Crystal Structure of TcdA-A1 Bound to A26.8 VHH CLOSTRIDIUM DIFFICILE; LAMA GLAMA lama glama clostridium difficile Murase, T., Eugenio, L., Schorr, M., Hussack, G., Tanha, J., Kitova, E.N., Klassen, J.S., Ng, K.K.S. 1.75 X-RAY DIFFRACTION 0.247 0.206 False True IGHV1 None None None None None 6xrt H L 0 G | E | F protein | protein | protein NA | NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 | envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 07/13/20 Cryo-EM structure of SHIV-elicited RHA1.V2.01 in complex with HIV-1 Env BG505 DS-SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV1 Lambda None None None None None 6ikm C c 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 4xvu E F 0 A protein nyv1 tmd HYDROLASE/TRANSPORT PROTEIN 01/28/15 Structure of Get3 bound to the transmembrane domain of Nyv1 SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE; HOMO SAPIENS, SYNTHETIC CONSTRUCT homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.35 X-RAY DIFFRACTION 0.234 0.197 False True IGHV3 IGKV1 Kappa None None None None None 6o2a O P 0 L | M peptide | protein NA | NA circumsporozoite protein | anti-kappa vhh domain IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein NDN and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum | lama glama Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.15 X-RAY DIFFRACTION 0.221 0.193 False True IGHV3 IGKV3 Kappa None None None None None 2esg A L 0 IMMUNE SYSTEM/TRANSPORT PROTEIN 10/26/05 Solution structure of the complex between immunoglobulin IgA1 and human serum albumin HOMO SAPIENS homo sapiens homo sapiens Almogren, A., Furtado, P.B., Sun, Z., Perkins, S.J., Kerr, M.A. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4kjp E F 0 B protein h(+)/cl(-) exchange transporter clca tranport protein, membrane protein 05/03/13 Structure of the CLC-ec1 deltaNC construct in the absence of halide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C 3.2 X-RAY DIFFRACTION 0.265 0.222 False True IGHV4 IGKV4 Kappa None None None None None 5mtl NA A 0 IMMUNE SYSTEM 01/10/17 Crystal structure of an amyloidogenic light chain HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.45 X-RAY DIFFRACTION 0.277 0.234 False True IGLV1 Lambda None None None None None 5gs1 H h 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 3cfb B A 0 B Hapten SPB 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID IMMUNE SYSTEM 03/03/08 High-resolution structure of blue fluorescent antibody EP2-19G2 in complex with stilbene hapten at 100K MUS MUSCULUS mus musculus mus musculus mus musculus Debler, E.W., Wilson, I.A. 1.6 X-RAY DIFFRACTION 0.218 0.186 False False IGHV5 IGKV2 Kappa None None None None None 7bep G I 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/24/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-384 and S309 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.61 X-RAY DIFFRACTION 0.241 0.203 False True IGHV1 IGKV3 Kappa None None None None None 6mfp C D 0 A protein clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 09/11/18 Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Young, B., Pazgier, M. 3.0 X-RAY DIFFRACTION 0.274 0.214 False True IGHV1 IGKV1 Kappa None None None None None 5vh3 H L 0 IMMUNE SYSTEM 04/12/17 Crystal structure of Fab fragment of the anti-TNFa antibody infliximab in a C-centered orthorhombic crystal form MUS MUSCULUS mus musculus mus musculus Mayclin, S.J., Edwards, T.E., Lerch, T.F., Conlan, H., Sharpe, P. 2.0 X-RAY DIFFRACTION 0.200 0.160 False True IGHV6 IGKV5 Kappa None None None None None 7si2 E D 0 B protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 10/12/21 Crystal structure of neutralizing antibody 10-28 in complex with SARS-CoV-2 spike receptor binding domain (RBD) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Reddem, E.R., Shapiro, L. 3.2 X-RAY DIFFRACTION 0.261 0.198 False True IGHV3 IGKV1 Kappa None None None None None 7m7i C D 0 A protein NA eryai BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2 (TE-free) SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS saccharopolyspora erythraea homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 5o04 E NA 0 B protein capsid protein VIRAL PROTEIN 05/16/17 GII.10 Vietnam 026 norovirus protruding domain in complex with Nanobody Nano-26 and Nano-85 NORWALK VIRUS; VICUGNA PACOS vicugna pacos norwalk virus Koromyslova, A.D., Hansman, A.D. 2.3 X-RAY DIFFRACTION 0.242 0.212 False True IGHV1 None None None None None 5thr R S 0 A protein bg505 sosip gp41 VIRAL PROTEIN 09/30/16 Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 8.9, 8.9 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 5muh NA A 0 IMMUNE SYSTEM 01/13/17 Crystal structure of an amyloidogenic light chain dimer H7 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Russo, R., Maritan, M., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.65 X-RAY DIFFRACTION 0.266 0.205 False True IGLV1 Lambda None None None None None 3dvf NA A 0 PROTEIN FIBRIL 07/18/08 Structure of amyloidogenic kappa 1 Bence Jones protein HOMO SAPIENS homo sapiens Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.8 X-RAY DIFFRACTION 0.266 0.193 False True IGKV1 Kappa None None None None None 6mb3 I R 0 E protein plasmodium falciparum recombinant shortened csp IMMUNE SYSTEM 08/29/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.37 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 6dcq M N 0 F | E | D protein | protein | protein NA | NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN 05/08/18 Ectodomain of full length, wild type HIV-1 glycoprotein clone PC64M18C043 in complex with PGT151 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Rantalainen, K. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 3raj H L 0 A protein adp-ribosyl cyclase 1 HYDROLASE/IMMUNE SYSTEM 03/28/11 Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zhang, H., Lee, H.C., Hao, Q. 3.044 X-RAY DIFFRACTION 0.275 0.205 False True IGHV2 IGKV13 Kappa None None None None None 4llw A B 0 IMMUNE SYSTEM 07/09/13 Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A HOMO SAPIENS homo sapiens homo sapiens Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S. 1.95 X-RAY DIFFRACTION 0.262 0.209 False True IGHV3 IGKV1 Kappa None None None None None 7d5z L K 0 I protein NA envelope glycoprotein h VIRAL PROTEIN 09/28/20 Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8 HUMAN GAMMAHERPESVIRUS 4; HOMO SAPIENS homo sapiens homo sapiens human gammaherpesvirus 4 Zhu, Q., Shan, S., Yu, J., Wang, X., Zhang, L., Zeng, M. 4.2 X-RAY DIFFRACTION 0.277 0.246 False True IGHV3 IGKV1 Kappa None None None None None 6ksn B NA 0 METAL BINDING PROTEIN 08/24/19 Structure of a Zn-bound camelid single domain antibody CAMELUS DROMEDARIUS camelus dromedarius Kumar, S., Athreya, A., Penmatsa, A. 2.15 X-RAY DIFFRACTION 0.232 0.193 False True IGHV1 None None None None None 3bky H L 0 P peptide b-lymphocyte antigen cd20 IMMUNE SYSTEM 12/07/07 Crystal Structure of Chimeric Antibody C2H7 Fab in complex with a CD20 Peptide HOMO SAPIENS, MUS MUSCULUS; SYNTHETIC CONSTRUCT homo sapiens, mus musculus homo sapiens, mus musculus Du, J., Zhong, C., Ding, J. 2.61 X-RAY DIFFRACTION 0.301 0.234 False True IGHV1 IGKV4 Kappa 4.35e-07 -8.67 SPR 18346788 7v0v A NA 19 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6cdi Q R 0 C protein glycoprotein 120 VIRAL PROTEIN 02/08/18 Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D. 3.6 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 7n0a B A 0 C protein NA leukemia inhibitory factor CYTOKINE/IMMUNE SYSTEM 05/25/21 Structure of Human Leukaemia Inhibitory Factor with Fab MSC1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Raman, S., Bosch, A., Fransson, J., Julien, J.P. 3.1 X-RAY DIFFRACTION 0.284 0.232 False True IGHV3 IGKV2 Kappa None None None None None 7nfa D B 0 NA NA NA NA IMMUNE SYSTEM 02/05/21 The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer HOMO SAPIENS homo sapiens homo sapiens Tang, J., Zhang, C., Dalby, P., Kozielski, F. 2.3 X-RAY DIFFRACTION 0.260 0.193 False True IGHV3 IGKV1 Kappa None None None None None 6wh9 B C 0 G protein NA kr1 OXIDOREDUCTASE/IMMUNE SYSTEM 04/07/20 Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10 SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Mathews, I.I., Khosla, C. 2.75 X-RAY DIFFRACTION 0.271 0.228 False True IGHV1 IGLV7 Lambda None None None None None 5l6q NA B 0 IMMUNE SYSTEM 05/31/16 Refolded AL protein from cardiac amyloidosis HOMO SAPIENS homo sapiens Annamalai, K., Liberta, F., Vielberg, M.-T., Lilie, H., Guehrs, K.-H., Schierhorn, A., Koehler, R., Schmidt, A., Haupt, C., Hegenbart, O., Schoenland, S., Groll, M., Faendrich, M. 1.4 X-RAY DIFFRACTION 0.182 0.147 False False IGLV3 Lambda None None None None None 6oij H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein subunit alpha-11 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/09/19 Muscarinic acetylcholine receptor 1-G11 protein complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Maeda, S., Qianhui, Q., Skiniotis, G., Kobilka, B. 3.3 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 4v1d A B 0 C protein beta-mammal toxin cn2 09/25/14 Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius. HOMO SAPIENS; CENTRUROIDES NOXIUS homo sapiens homo sapiens centruroides noxius RIANO-UMBARILA, L., SERRANO-POSADA, H., ROJAS-TREJO, S., RUDINO-PINERA, E., BECERRIL, B. 3.1 X-RAY DIFFRACTION 0.2294 0.1848 False True IGHV3 IGKV3 Kappa None None None None None 5uk0 H h 0 C protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 2 HOMO SAPIENS; INFLUENZA A VIRUS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6nf5 K N 0 B protein hiv-1 env bg505 md64 n332-gt5 sosip gp41 VIRAL PROTEIN/immune system 12/18/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Steichen, J.M., Schief, W.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY False True IGHV3 IGLV2 Lambda None None None None None 7k8o H L 0 NA NA NA NA IMMUNE SYSTEM 09/27/20 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C110 HOMO SAPIENS homo sapiens homo sapiens Jette, C.A., Barnes, C.O., Bjorkman, P.J. 1.95 X-RAY DIFFRACTION 0.237 0.204 False True IGHV3 IGKV1 Kappa None None None None None 7lxy H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2X333 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 6o3j A B 0 I peptide mper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41) and phosphatidic acid (06:0 PA) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 3.416 X-RAY DIFFRACTION 0.265 0.215 False True IGHV1 IGKV3 Kappa None None None None None 1y0l D C 0 D Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/15/04 Catalytic elimination antibody 34E4 in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.239 0.204 False True IGHV4 IGLV1 Lambda 1e-09 -12.27819680469229 Unknown TBD 5g64 H L 0 A protein ig epsilon chain c region IMMUNE SYSTEM 06/14/16 The complex between human IgE-Fc and two anti-IgE Fab fragments HOMO SAPIENS homo sapiens homo sapiens homo sapiens Davies, A.M., Allan, E.G., Keeble, A.H., Delgado, J., Cossins, B.P., Mitropoulou, A.N., Pang, M.O.Y., Ceska, T., Beavil, A.J., Craggs, G., Westwood, M., Henry, A.J., McDonnell, J.M., Sutton, B.J. 3.715 X-RAY DIFFRACTION 0.309 0.259 False True IGHV3 IGKV1 Kappa None None None None None 4hkb I K 0 IMMUNE SYSTEM 10/15/12 CH67 Fab (unbound) from the CH65-67 Lineage HOMO SAPIENS homo sapiens homo sapiens Schmidt, A.G., Harrison, S.C. 3.6 X-RAY DIFFRACTION 0.306 0.258 False True IGHV1 IGLV3 Lambda None None None None None 6gkd J NA 0 I protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 7we9 C L 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv289 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 6xca H L 0 NA NA NA NA IMMUNE SYSTEM 06/08/20 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C105 HOMO SAPIENS homo sapiens homo sapiens Sharaf, N.G., Barnes, C.O., Bjorkman, P.J. 1.8 X-RAY DIFFRACTION 0.214 0.186 False True IGHV3 IGLV2 Lambda None None None None None 6bzu E F 0 K peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 19B3 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus Tzarum, N., Alemn, F., Kong, L., Wilson, I.A., Law, M. 2.7 X-RAY DIFFRACTION 0.290 0.265 False True IGHV3 IGKV3 Kappa None None None None None 4n9g H L 0 Y peptide epitope scaffold rsv_1isea_ffl_001_c IMMUNE SYSTEM 10/21/13 Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9 MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta synthetic construct Carrico, C.T.D., Strong, R.K. 2.5 X-RAY DIFFRACTION 0.295 0.263 False True IGHV4 IGKV1 Kappa 3.26e-10 -12.942286816628542 Unknown TBD 6wno B C 0 A protein NA plasmodium vivax reticulocyte binding protein 2b CELL INVASION 04/23/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 243244 HOMO SAPIENS; PLASMODIUM VIVAX (STRAIN SALVADOR I) homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 3.35 X-RAY DIFFRACTION 0.284 0.245 False True IGHV3 IGLV2 Lambda None None None None None 6n4q J I 0 A | B | F protein | protein | peptide NA | NA | NA nav1.7 vsd2-navab chimera | nav1.7 vsd2-navab chimera | beta/omega-theraphotoxin-tp2a MEMBRANE PROTEIN 11/20/18 CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2 ARCOBACTER BUTZLERI (STRAIN RM4018); HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus arcobacter butzleri (strain rm4018), homosapiens | arcobacter butzleri (strain rm4018), homosapiens | thrixopelma pruriens Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 3nn8 G H 0 IMMUNE SYSTEM 06/23/10 Crystal structure of engineered antibody fragment based on 3D5 MUS MUSCULUS mus musculus mus musculus Lieberman, R.L., Maynard, J.A., Drury, J.E., Pai, J., Culver, J.A. 3.1 X-RAY DIFFRACTION 0.238 0.183 True True IGHV1 IGKV1 Kappa None None None None None 2kh2 B b 36 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5ur8 A B 0 IMMUNE SYSTEM 02/09/17 Human antibody fragment (Fab) to meningococcal Factor H binding protein HOMO SAPIENS homo sapiens homo sapiens Beernink, P.T. 1.755 X-RAY DIFFRACTION 0.222 0.198 False True IGHV5 IGKV1 Kappa None None None None None 5ocl G NA 0 IMMUNE SYSTEM 07/03/17 Nanobody-anti-VGLUT nanobody complex VICUGNA PACOS; LAMA GLAMA lama glama Dutzler, R., Schenck, S., Kunz, L. 2.2 X-RAY DIFFRACTION 0.208 0.188 False True IGHV1 None None None None None 7li9 B C 0 A protein NA sodium-dependent serotonin transporter MEMBRANE PROTEIN 01/26/21 5-HT bound serotonin transporter reconstituted in lipid nanodisc in KCl HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Yang, D., Gouaux, E. 3.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 4bh8 B A 0 P peptide dodecapeptide antigen IMMUNE SYSTEM 03/30/13 CRYSTAL STRUCTURE OF GERMLINE ANTIBODY 36-65 IN COMPLEX WITH PEPTIDE GDPRPSYISHLL MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.4 X-RAY DIFFRACTION 0.2510 0.2305 False False IGHV1 IGKV10 Kappa None None None None None 5hdo C NA 0 IMMUNE SYSTEM 01/05/16 Crystal structure of a nanobody raised against urokinase-type plasminogen activator CAMELUS DROMEDARIUS camelus dromedarius Kromann-Hansen, T. 2.16 X-RAY DIFFRACTION 0.218 0.177 False True IGHV1 None None None None None 3wkm H L 0 A protein putative zinc metalloprotease aq_1964 HYDROLASE 10/28/13 The periplasmic PDZ tandem fragment of the RseP homologue from Aquifex aeolicus in complex with the Fab fragment AQUIFEX AEOLICUS; MUS MUSCULUS mus musculus mus musculus aquifex aeolicus Nogi, T., Tabata, S., Tamura-kawakami, K., Takagi, J. 2.2 X-RAY DIFFRACTION 0.272 0.224 False False IGHV14 IGKV3 Kappa None None None None None 6ol7 E D 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV5 IGKV8 Kappa None None None None None 1nc2 D C 0 D Hapten DOE (S)-2-(4-(2-(2-HYDROXYETHYLTHIO)-ACETAMIDO)-BENZYL)-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETATE Immune system 12/04/02 Crystal Structure of Monoclonal Antibody 2D12.5 Fab Complexed with Y-DOTA MUS MUSCULUS mus musculus mus musculus mus musculus Corneillie, T.M., Fisher, A.J., Meares, C.F. 2.1 X-RAY DIFFRACTION 0.247 0.209 False False IGHV2 IGLV1 Lambda None None None None None 7l2f G J 0 C protein NA spike glycoprotein Viral Protein/IMMUNE SYSTEM 12/16/20 Cryo-EM structure of NTD-directed neutralizing antibody 5-24 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Cerutti, G., Shapiro, L. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 5gs1 L l 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 3ogo F NA 0 C protein green fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 08/17/10 Structure of the GFP:GFP-nanobody complex at 2.8 A resolution in spacegroup P21212 AEQUOREA VICTORIA; CAMELUS DROMEDARIUS camelus dromedarius aequorea victoria Kubala, M.H., Kovtun, O., Alexandrov, K., Collins, B.M. 2.8 X-RAY DIFFRACTION 0.253 0.202 False True IGHV1 1.40e-09 -12.56 Other 37 20945358 5gru H h 0 A protein maltose-binding periplasmic protein IMMUNE SYSTEM 08/12/16 Structure of mono-specific diabody ESCHERICHIA COLI; MUS MUSCULUS; HOMO SAPIENS homo sapiens escherichia coli Kim, J.H., Song, D.H., Youn, S.J., Cho, G., Lee, H., Lee, J.O. 1.955 X-RAY DIFFRACTION 0.237 0.197 True True unknown unknown unknown None None None None None 7dzx H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 01/26/21 Spike protein from SARS-CoV2 with Fab fragment of enhancing antibody 8D2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, Y., Soh, W.T., Li, S., Kishikawa, J., Hirose, M., Kato, T., Standley, D., Okada, M., Arase, H. 3.53 ELECTRON MICROSCOPY / HOMOLOGY MODEL NA NA False True IGHV3 IGKV1 Kappa None None None None None 4m93 B C 0 IMMUNE SYSTEM 08/14/13 Unliganded 2 crystal structure of S25-26 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.09 X-RAY DIFFRACTION 0.251 0.218 False False IGHV2 IGKV1 Kappa None None None None None 2htl E F 0 B protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 07/26/06 Structure of the Escherichia coli ClC chloride channel Y445F mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.4 X-RAY DIFFRACTION 0.302 0.259 False False IGHV4 IGKV4 Kappa None None None None None 6ram C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return conformation with wider opened intracellular gate THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 3.8 ELECTRON MICROSCOPY False True IGHV1 None None None None None 5id0 B A 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with aminoheptanoic acid-linked meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.48 X-RAY DIFFRACTION 0.208 0.160 False True IGHV2 IGKV5 Kappa 1.7e-06 -7.871075957560247 Unknown TBD 3a6b H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 08/28/09 Crystal Structure of HyHEL-10 Fv mutant LN32D complexed with hen egg white lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Yokota, A., Tsumoto, K., Shiroishi, M., Nakanishi, T., Kondo, H., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.222 0.194 False True IGHV3 IGKV5 Kappa 1.08e-07 -9.63 ITC 30 20038580 7rth g NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 1rjl B A 0 C protein outer surface protein b IMMUNE SYSTEM 11/19/03 Structure of the complex between OspB-CT and bactericidal Fab-H6831 BORRELIA BURGDORFERI; MUS MUSCULUS mus musculus mus musculus borrelia burgdorferi Becker, M., Bunikis, J., Lade, B.D., Dunn, J.J., Barbour, A.G., Lawson, C.L. 2.6 X-RAY DIFFRACTION 0.235 0.191 False False IGHV1 IGKV11 Kappa None None None None None 7obf B NA 0 NA NA NA NA HYDROLASE 04/22/21 Crystal structure of the human VH antibody domain HEL4 HOMO SAPIENS homo sapiens Belviso, B.D., Caliandro, R., Carrozzini, B. 2.699 X-RAY DIFFRACTION 0.264 0.214 False False IGHV3 NA NA None None None None None 7pgb H L 0 c protein NA unknown MEMBRANE PROTEIN 08/13/21 NaV_Ae1/Sp1CTD_pore-SAT09 complex HOMO SAPIENS; ALKALILIMNICOLA EHRLICHII (STRAIN ATCC BAA-1101 / DSM 17681 / MLHE-1); RUEGERIA POMEROYI (STRAIN ATCC 700808 / DSM 15171 / DSS-3) homo sapiens homo sapiens alkalilimnicola ehrlichii (strain atcc baa-1101/ dsm 17681 / mlhe-1), ruegeria pomeroyi (strain atcc 700808 / dsm 15171 / dss-3) Lolicato, M., Arrigoni, C. 3.6 X-RAY DIFFRACTION 0.232 0.207 False True IGHV3 IGKV1 Kappa None None None None None 4k24 H L 0 U protein urokinase plasminogen activator surface receptor IMMUNE SYSTEM 04/08/13 Structure of anti-uPAR Fab ATN-658 in complex with uPAR HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Huang, M.D., Xu, X., Yuan, C. 4.5 X-RAY DIFFRACTION 0.275 0.217 False False IGHV1 IGKV1 Kappa 5.4e-07 -8.550544767912342 Saturation Analysis TBD 4xnu H L 0 A protein integral membrane protein-dopamine transporter transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter in complex with nisoxetine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Aravind, P., Wang, K., Gouaux, E. 2.98 X-RAY DIFFRACTION 0.251 0.226 False True IGHV5 IGKV4 Kappa None None None None None 6dba A NA 0 IMMUNE SYSTEM 05/02/18 Crystal Structure of VHH R303 CAMELUS DROMEDARIUS camelus dromedarius Brooks, C.L., Toride King, M., Huh, I. 1.3 X-RAY DIFFRACTION 0.182 0.161 False True IGHV1 None None None None None 2o5x H L 0 IMMUNE SYSTEM 12/06/06 Crystal structure of 1E9 LeuH47Trp/ArgH100Trp, an engineered Diels-Alderase Fab with nM steroid-binding affinity MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Verdino, P., Wilson, I.A. 2.05 X-RAY DIFFRACTION 0.204 0.178 False True IGHV7 IGKV2 Kappa None None None None None 3sy0 B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 07/15/11 S25-2- A(2-8)-A(2-4)KDO trisaccharide complex MUS MUSCULUS mus musculus mus musculus mus musculus Nguyen, H.P., Seto, N.O., Mackenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.489 X-RAY DIFFRACTION 0.212 0.187 False True IGHV7 IGKV8 Kappa None None None None None 6woq J K 0 E protein NA envelope glycoprotein e2 IMMUNE SYSTEM/Viral Protein 04/25/20 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody HC1AM and non neutralizing antibody E1 HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Law, M. 3.667 X-RAY DIFFRACTION 0.277 0.227 False True IGHV1 IGKV3 Kappa None None None None None 1c5d B A 0 IMMUNE SYSTEM 11/17/99 THE CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A RAT MONOCLONAL ANTIBODY AGAINST THE MAIN IMMUNOGENIC REGION OF THE HUMAN MUSCLE ACETYLCHOLINE RECEPTOR RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Kontou, M., Leonidas, D.D., Vatzaki, E.H., Tsantili, P., Mamalaki, A., Oikonomakos, N.G., Acharya, K.R., Tzartos, S.J. 2.4 X-RAY DIFFRACTION 0.304 0.196 False False IGHV2 IGKV19 Kappa None None None None None 5kem D E 0 A protein ebola secreted glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91 HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 5.5 ELECTRON MICROSCOPY False True IGHV8 IGKV6 Kappa None None None None None 7uap O P 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/13/22 Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1520 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV4 Lambda None None None None None 1nc4 B A 0 B Hapten DOF (S)-2-(4-NITROBENZYL)-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETATE Immune system 12/04/02 Crystal Structure of Monoclonal Antibody 2D12.5 Fab Complexed with Gd-DOTA MUS MUSCULUS mus musculus mus musculus mus musculus Corneillie, T.M., Fisher, A.J., Meares, C.F. 2.25 X-RAY DIFFRACTION 0.248 0.208 False False IGHV2 IGLV1 Lambda None None None None None 6gku H L 0 A protein galectin-10 SUGAR BINDING PROTEIN 05/21/18 Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5 HOMO SAPIENS; LAMA GLAMA lama glama lama glama homo sapiens Verstraete, K., Verschueren, K., Savvides, S.N. 1.91 X-RAY DIFFRACTION 0.201 0.166 False True IGHV3 IGLV2 Lambda None None None None None 6s3t E I 0 T protein 46 kda surface antigen PROTEIN BINDING 06/26/19 P46, an immunodominant surface protein from Mycoplasma hyopneumoniae MYCOPLASMA HYOPNEUMONIAE J; MUS MUSCULUS mus musculus mus musculus mycoplasma hyopneumoniae j Guasch, A., Fita, I. 3.5 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 2ltq F E 5 D protein disulfide bond formation protein b MEMBRANE PROTEIN, OXIDOREDUCTASE 05/30/12 High resolution structure of DsbB C41S by joint calculation with solid-state NMR and X-ray data ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Tang, M., Sperling, L.J., Schwieters, C.D., Nesbitt, A.E., Gennis, R.B., Rienstra, C.M. NOT SOLID-STATE NMR False False IGHV5 IGKV8 Kappa None None None None None 3lrh NA K 0 L peptide huntingtin IMMUNE SYSTEM 02/11/10 Structure of anti-huntingtin VL domain in complex with huntingtin peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens Schiefner, A., Chatwell, L., Skerra, A. 2.6 X-RAY DIFFRACTION 0.278 0.216 False True IGLV1 Lambda 4.5000000000000006e-08 -10.022811404235208 Unknown TBD 6dfg I K 0 D protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 05/14/18 BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Steichen, J.M., Schief, W.R., Ward, A.B. 4.42 ELECTRON MICROSCOPY False True unknown IGLV3 Lambda None None None None None 4mwf H L 0 C protein envelope glycoprotein e2 IMMUNE SYSTEM 09/24/13 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core bound to broadly neutralizing antibody AR3C HOMO SAPIENS; HEPATITIS C VIRUS (ISOLATE H) homo sapiens homo sapiens hepatitis c virus (isolate h) Kong, L., Wilson, I.A., Law, M. 2.645 X-RAY DIFFRACTION 0.270 0.231 False True IGHV1 IGKV3 Kappa None None None None None 6ch7 Q R 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.8 X-RAY DIFFRACTION 0.262 0.232 False True unknown IGLV3 Lambda None None None None None 7rk1 D d 0 B protein NA capsid polyprotein vp70 VIRAL PROTEIN 07/21/21 Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 3E8, an astrovirus-neutralizing antibody, at 2.05-A resolution HUMAN ASTROVIRUS-8; MUS MUSCULUS mus musculus human astrovirus-8 Meyer, L., DuBois, R.M. 2.05 X-RAY DIFFRACTION 0.238 0.223 True True unknown unknown unknown None None None None None 6vep C D 0 E protein insulin receptor subunit alpha HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM 06/03/20 Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Lawrence, M.C., Menting, J.G.T. 2.9 X-RAY DIFFRACTION 0.225 0.193 False True IGHV2 IGKV8 Kappa None None None None None 7lg6 O Q 0 E protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/21 BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Torres, J.L., Wu, N.R., Ward, A.B. 3.28 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6nf2 W X 0 R protein envelope glycoprotein gp41 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 3hi1 B A 0 J protein glycoprotein 120 STRUCTURAL PROTEIN/Immune System 05/18/09 Structure of HIV-1 gp120 (core with V3) in Complex with CD4-Binding-Site Antibody F105 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 Kwon, Y.D., Chen, L., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z., Zhang, M.-Y., Arthos, J., Burton, D.R., Dimitrov, D., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.243 0.202 False False IGHV4 IGKV3 Kappa 1.12e-08 -10.84 SPR 19965434 2bx5 NA J 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 1shm E NA 0 IMMUNE SYSTEM 02/26/04 Convergent solutions to VHH domain stabilization from natural and in vitro evolution LAMA GLAMA lama glama Bond, C.J., Wiesmann, C., Marsters, J.C., Sidhu, S.S. 1.9 X-RAY DIFFRACTION 0.236 0.185 False True IGHV1 None None None None None 4okv C D 0 E protein anti-platelet aggregation protein BLOOD CLOTTING 01/23/14 Crystal structure of anopheline anti-platelet protein with Fab antibody ANOPHELES STEPHENSI; MUS MUSCULUS mus musculus mus musculus anopheles stephensi Park, S.Y., Sugiyama, K. 1.802 X-RAY DIFFRACTION 0.250 0.218 False False IGHV1 IGKV1 Kappa None None None None None 7czq H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P2B-1A10 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4nkd G H 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.303 X-RAY DIFFRACTION 0.231 0.195 False True IGHV1 IGKV1 Kappa None None None None None 2fd6 H L 0 U protein urokinase plasminogen activator surface receptor IMMUNE SYSTEM, HYDROLASE 12/13/05 Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Huang, M., Huai, Q., Li, Y. 1.9 X-RAY DIFFRACTION 0.276 0.239 False False IGHV1 IGKV4 Kappa None None None None None 6qu9 H L 0 PROTEIN BINDING 02/26/19 Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin MUS MUSCULUS mus musculus mus musculus Jagger, A.M., Heyer-Chauhan, N., Lomas, D.A., Irving, J.A. 1.9 X-RAY DIFFRACTION 0.233 0.202 False False IGHV1 IGKV19 Kappa None None None None None 5ggs A B 0 Z protein programmed cell death protein 1 IMMUNE SYSTEM 06/16/16 PD-1 in complex with pembrolizumab Fab HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Heo, Y.S. 1.997 X-RAY DIFFRACTION 0.228 0.180 False True IGHV1 IGKV3 Kappa None None None None None 4buh B b 0 06/20/13 Human IgE against the major allergen Bet v 1 - Crystal structure of clone M0418 scFv HOMO SAPIENS homo sapiens Davies, A.M., Levin, M., Lilljekvist, M., Carlsson, F., Gould, H.J., Sutton, B.J., Ohlin, M. 1.3 X-RAY DIFFRACTION 0.1728 0.1453 True True unknown unknown unknown None None None None None 6i9i A B 0 C protein glycoprotein VIRAL PROTEIN 11/23/18 Rift valley fever virus Gn in complex with a neutralizing antibody fragment ORYCTOLAGUS CUNICULUS; RIFT VALLEY FEVER VIRUS oryctolagus cuniculus oryctolagus cuniculus rift valley fever virus Allen, E.R., Bowden, T.A. 1.98 X-RAY DIFFRACTION 0.243 0.203 False True IGHV1 IGKV1 Kappa None None None None None 5jof E F 0 IMMUNE SYSTEM 05/02/16 Crystal structure of VRC03 gHVgLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 3.208 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 IGKV3 Kappa None None None None None 5o6v I M 0 C protein genome polyprotein VIRUS 06/07/17 The cryo-EM structure of Tick-borne encephalitis virus complexed with Fab fragment of neutralizing antibody 19/1786 TICK-BORNE ENCEPHALITIS VIRUS (STRAIN HYPR); MUS MUSCULUS mus musculus mus musculus tick-borne encephalitis virus (strain hypr) Fuzik, T., Plevka, P. 3.9, 3.9 ELECTRON MICROSCOPY False False IGHV5 IGKV6 Kappa None None None None None 5wob Q R 0 E protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 2gfb D C 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 1vhp A NA 10 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 2kqm NA B 7 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6lxi H L 0 A protein NA neuraminidase HYDROLASE/IMMUNE SYSTEM 02/11/20 Crystal structure of Z2B3 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) INFLUENZA A VIRUS (STRAIN A/BREVIG MISSION/1/1918 H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/brevigmission/1/1918 h1n1) Jiang, H., Peng, W., Qi, J., Chai, Y., Song, H., Shi, Y., Gao, G.F., Wu, Y. 2.5 X-RAY DIFFRACTION 0.212 0.183 False True IGHV1 IGLV2 Lambda None None None None None 7tqa C D 0 NA NA NA NA IMMUNE SYSTEM 01/26/22 Crystal Structure of monoclonal S9.6 Fab SYNTHETIC CONSTRUCT synthetic construct synthetic construct Bou Nader, C., Zhang, J. 2.328 X-RAY DIFFRACTION 0.235 0.179 False True IGHV1 IGKV1 Kappa None None None None None 6gk7 H L 0 A peptide human tau peptide a8119 residues 299-318 IMMUNE SYSTEM 05/18/18 Crystal structure of anti-tau antibody dmCBTAU-27.1, double mutant (S31Y, T100I) of CBTAU-27.1, in complex with Tau peptide A8119B (residues 299-318) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Steinbacher, S., Mrosek, M., Juraszek, J. 2.95 X-RAY DIFFRACTION 0.268 0.220 False True IGHV5 IGKV4 Kappa None None None None None 6obd B A 0 E peptide gld52 peptide mimetic IMMUNE SYSTEM 03/20/19 Crystal structure of anti-GLD52 Fab complex with human GLD52 peptide mimetic MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Wei, R. 2.2 X-RAY DIFFRACTION 0.307 0.234 False True IGHV3 IGKV1 Kappa None None None None None 6qd6 H NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 1h0d B A 0 C protein angiogenin IMMUNE SYSTEM/HYDROLASE 06/19/02 Crystal structure of Human Angiogenin in complex with Fab fragment of its monoclonal antibody mAb 26-2F HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chavali, G.B., Papageorgiou, A.C., Acharya, K.R. 2.0 X-RAY DIFFRACTION 0.272 0.232 False True IGHV5 IGKV3 Kappa None None None None None 3se9 H L 0 G protein hiv-1 clade ae strain 93th057 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/10/11 Crystal structure of broadly and potently neutralizing antibody VRC-PG04 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwong, P.D., Zhou, T. 2.0 X-RAY DIFFRACTION 0.233 0.190 False True IGHV1 IGKV3 Kappa None None None None None 6msy H L 0 H carbohydrate MAN polysaccharide IMMUNE SYSTEM 10/18/18 Anti-HIV-1 Fab Fab 2G12 + Man4 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 1.999 X-RAY DIFFRACTION 0.242 0.206 False True unknown IGKV1 Kappa 1e-07 -9.54970862587178 Unknown TBD 6ot1 A C 0 O protein envelope glycoprotein gp41 IMMUNE SYSTEM 05/02/19 Cryo-EM structure of vaccine-elicited antibody 0PV-b.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.5 ELECTRON MICROSCOPY False True IGHV4 IGKV2 Kappa None None None None None 7lf1 O Q 0 N protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.04 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5w9i G H 0 E protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 3.6 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 3piq C D 0 IMMUNE SYSTEM 11/07/10 Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1 HOMO SAPIENS homo sapiens homo sapiens Changela, A., Gorny, M.K., Zolla-Pazner, S., Kwong, P.D. 3.325 X-RAY DIFFRACTION 0.299 0.236 False True IGHV3 IGLV3 Lambda None None None None None 7km6 H L 0 NA NA NA NA IMMUNE SYSTEM 11/02/20 APOBEC3B antibody 5G7 Fv-clasp HOMO SAPIENS homo sapiens homo sapiens Tang, H., Shi, K., Aihara, H. 1.67 X-RAY DIFFRACTION 0.238 0.189 False True IGHV5 IGKV8 Kappa None None None None None 7ki4 G F 0 E protein NA fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 10/23/20 Structure of the NiV F glycoprotein in complex with the 12B2 neutralizing antibody NIPAH VIRUS; MUS MUSCULUS mus musculus mus musculus nipah virus Dang, H.V., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV2 IGKV12 Kappa None None None None None 4jo2 I M 0 Q peptide gp120 IMMUNE SYSTEM/VIRAL PROTEIN 03/16/13 Crystal structure of rabbit mAb R56 Fab in complex with V3 crown of HIV-1 Consensus A gp120 ORYCTOLAGUS CUNICULUS; HUMAN IMMUNODEFICIENCY VIRUS 1 oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R.M., Kong, X.P. 2.5 X-RAY DIFFRACTION 0.265 0.190 False True IGHV1 IGKV1 Kappa None None None None None 6wg0 H L 0 P peptide NA npna3 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab366 in complex with NPNA3 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 1.599 X-RAY DIFFRACTION 0.211 0.189 False True IGHV1 IGKV1 Kappa None None None None None 3uzq A a 0 B protein envelope protein IMMUNE SYSTEM 12/07/11 Crystal structure of the dengue virus serotype 1 envelope protein domain III in complex with the variable domains of Mab 4E11 MUS MUSCULUS; DENGUE VIRUS 1 mus musculus dengue virus 1 Cockburn, J.J.B., Navarro Sanchez, M.E., Fretes, N., Urvoas, A., Staropoli, I., Kikuti, C.M., Coffey, L.L., Arenzana Seisdedos, F., Bedouelle, H., Rey, F.A. 1.6 X-RAY DIFFRACTION 0.188 0.176 True True unknown unknown unknown 8.200000000000001e-11 -13.760019836577097 ELISA TBD 2mkw NA A 3 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 7fcq H L 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 07/15/21 Crystallographic structure of neutralizing antibody P14-44 in complex with SARS-CoV-2 spike receptor-binding Domain (RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, P., Jin, T. 1.89 X-RAY DIFFRACTION 0.201 0.165 False True IGHV1 IGLV2 Lambda None None None None None 5c7x H L 0 A protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 06/25/15 Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M. 2.95 X-RAY DIFFRACTION 0.276 0.234 False True IGHV3 IGLV3 Lambda 4e-13 -16.913816377693745 Unknown TBD 4bjl NA A 0 IMMUNOGLOBULIN 05/26/95 LOCW, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN DISTILLED WATER HOMO SAPIENS homo sapiens Schiffer, M., Huang, D.B. 2.4 X-RAY DIFFRACTION unknown unknown False False IGLV1 Lambda None None None None None 1xgu B A 0 C protein unknown protein IMMUNE SYSTEM 09/17/04 Structure for antibody HyHEL-63 Y33F mutant complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS escherichia coli Li, Y., Huang, Y., Swaminathan, C.P., Smith-Gill, S.J., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.239 0.223 False True IGHV3 IGKV5 Kappa None None None None None 7bpk C D 0 A protein NA envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 03/23/20 Zika virus envelope protein mutant bound to mAb ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Dai, L., Qi, J., Gao, G.F. 3.1 X-RAY DIFFRACTION 0.268 0.232 False True IGHV3 IGLV1 Lambda None None None None None 7cwm I K 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 Complex of SARS-CoV-2 spike protein and Fab P17 with one RBD in open state and two RBD in closed state SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, N., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6x9v H L 0 B | A protein | protein NA | NA hiv-1 envelope glycoprotein bg505 sosip.664 gp41 | hiv-1 envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/03/20 HIV-1 Envelope Glycoprotein BG505 SOSIP.664, expressed in HEK293S cells and deglycosylated by endoglycosidase H, in complex with RM20A3 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6xul C D 0 NA NA NA NA ANTITUMOR PROTEIN 01/20/20 Apo Ab 5b1 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.230 0.168 False True IGHV3 IGLV1 Lambda None None None None None 7lsg H L 0 C protein NA core protein IMMUNE SYSTEM/VIRAL PROTEIN 02/18/21 Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Siberian Subtype) HOMO SAPIENS; TICK-BORNE ENCEPHALITIS VIRUS homo sapiens homo sapiens tick-borne encephalitis virus Keeffe, J.R., Bjorkman, P.J. 1.86 X-RAY DIFFRACTION 0.212 0.187 False True IGHV3 IGKV3 Kappa None None None None None 7rcs H L 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM 07/08/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.160 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 2.4 X-RAY DIFFRACTION 0.253 0.188 False True IGHV1 IGKV4 Kappa None None None None None 6n5e E D 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/21/18 Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope INFLUENZA A VIRUS; MUS MUSCULUS influenza a virus mus musculus influenza a virus Bajic, G., Schmidt, A.G. 3.0 X-RAY DIFFRACTION 0.287 0.250 False True IGHV5 IGLV1 Lambda None None None None None 6njl I i 0 C protein glutamate receptor 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.7 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6uup B b 0 NA NA NA NA ANTITUMOR PROTEIN 10/31/19 Structure of anti-hCD33 conditional scFv CAMELIDAE MIXED LIBRARY camelidae mixed library Kimberlin, C.R., Park, S. 2.20002 X-RAY DIFFRACTION 0.237 0.197 True True unknown unknown unknown None None None None None 7sfx G H 0 NA NA NA NA IMMUNE SYSTEM 10/04/21 10A1 Fab in complex with CD99 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Romero, L.A., Hattori, T., Koide, S. 3.1 X-RAY DIFFRACTION 0.248 0.226 False True IGHV6 IGLV3 Lambda None None None None None 1n0x K M 0 R peptide b2.1 peptide IMMUNE SYSTEM 10/15/02 Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Saphire, E.O., Montero, M., Menendez, A., Irving, M.B., Zwick, M.B., Parren, P.W.H.I., Burton, D.R., Scott, J.K., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.252 0.220 False True IGHV1 IGKV3 Kappa None None None None None 6z7y D C 0 F | E peptide | peptide NA | NA insulin | insulin HORMONE 06/02/20 Human insulin in complex with the analytical antibody OXI-005 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens | homo sapiens Johansson, E. 2.2 X-RAY DIFFRACTION 0.253 0.217 False True IGHV5 IGKV19 Kappa None None None None None 7lq7 T U 0 B protein NA spike protein s1 IMMUNE SYSTEM 02/13/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yuan, M., Zhu, X., Wilson, I.A. 3.4 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 IGKV1 Kappa None None None None None 6tnp F E 0 I unknown NO8 unknown IMMUNE SYSTEM 12/09/19 Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide MUS MUSCULUS mus musculus mus musculus mus musculus Macias-Leon, J., Corzana, F., Hurtado-Guerrero, R. 3.0 X-RAY DIFFRACTION 0.251 0.203 False True IGHV1 IGKV8 Kappa None None None None None 7l6v E NA 0 A protein NA bont/a ANTITOXIN 12/24/20 Crystal structure of BoNT/A-LC-JPU-A5-JPU-C1-JPU-H7-JPU-D12-ciA-F12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.01 X-RAY DIFFRACTION 0.234 0.197 False True IGHV1 NA NA None None None None None 2kqn NA B 9 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 2fx9 I M 0 Q peptide fragment of hiv glycoprotein gp41 IMMUNE SYSTEM 02/03/06 Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a thioether-linked peptide encompassing the 4e10 epitope on gp41 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Cardoso, R.M.F., Brunel, F.M., Ferguson, S., Burton, D.R., Dawson, P.E., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.271 0.236 False True IGHV1 IGKV3 Kappa 1.70e-08 -10.59 SPR 17125793 6huo G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 10/09/18 CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38. BOS TAURUS; HOMO SAPIENS; LAMA GLAMA lama glama bos taurus, homo sapiens | homo sapiens Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R. 3.26 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 7ndd H L 0 B protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/30/21 EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-159 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhao, Y., Ren, J., Stuart, D. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 3j42 G H 0 E protein prm VIRUS/IMMUNE SYSTEM 06/13/13 Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody MUS MUSCULUS; DENGUE VIRUS 2 mus musculus mus musculus dengue virus 2 Wang, Z., Pennington, J.G., Jiang, W., Rossmann, M.G. 21 ELECTRON MICROSCOPY False True IGHV5 IGKV6 Kappa None None None None None 7sn2 H L 0 A protein NA spike glycoprotein IMMUNE SYSTEM 10/27/21 Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pan, J., Abraham, J., Yang, P., Shankar, S. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7lkf H L 0 A protein NA sterol regulatory element-binding protein cleavage-activating protein LIPID BINDING PROTEIN 02/02/21 WT Chicken Scap L1-L7 / Fab 4G10 complex focused refinement GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Kober, D.L., Radhakrishnan, A., Goldstein, J.L., Brown, M.S., Clark, L.D., Bai, X.-C., Rosenbaum, D.M. 2.9 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV10 Kappa None None None None None 6fg1 H L 0 IMMUNE SYSTEM 01/09/18 CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA32. HOMO SAPIENS homo sapiens homo sapiens Bertrand, T., Pouzieux, S. 2.03 X-RAY DIFFRACTION 0.285 0.266 False True IGHV1 IGKV19 Kappa None None None None None 6udj K L 0 J protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 09/19/19 HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Abernathy, M.E., Barnes, C.O., Gristick, H.B., Bjorkman, P.J. 2.5 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 4rgn F G 0 S protein enterotoxin type b TOXIN/IMMUNE SYSTEM 09/30/14 Structure of Staphylococcal Enterotoxin B bound to two neutralizing antibodies, 14G8 and 6D3 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Franklin, M.C., Dutta, K., Varshney, A.K., Goger, M.J., Fries, B.C. 2.698 X-RAY DIFFRACTION 0.278 0.240 False False IGHV1 IGKV8 Kappa None None None None None 2hfe A B 0 C protein kcsa channel MEMBRANE PROTEIN 06/23/06 Rb+ complex of a K channel with an amide to ester substitution in the selectivity filter MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Valiyaveetil, F.I., MacKinnon, R., Muir, T.W. 2.25 X-RAY DIFFRACTION 0.251 0.232 False True IGHV1 IGKV5 Kappa None None None None None 7wpf W NA 0 NA NA NA NA VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA lama glama Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5y9f d c 0 J protein NA major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 6u52 A NA 0 B protein nucleoprotein IMMUNE SYSTEM 08/26/19 Anti-Sudan ebolavirus Nucleoprotein Single Domain Antibody Sudan B (SB) Complexed with Sudan ebolavirus Nucleoprotein C-terminal Domain 634-738 LAMA GLAMA; SUDAN EBOLAVIRUS (STRAIN BONIFACE-76) lama glama sudan ebolavirus (strain boniface-76) Taylor, A.B., Sherwood, L.J., Hart, P.J., Hayhurst, A. 1.9 X-RAY DIFFRACTION 0.243 0.198 False True unknown unknown unknown None None None None None 2mcg NA 1 0 IMMUNOGLOBULIN 05/09/89 THREE-DIMENSIONAL STRUCTURE OF A LIGHT CHAIN DIMER CRYSTALLIZED IN WATER. CONFORMATIONAL FLEXIBILITY OF A MOLECULE IN TWO CRYSTAL FORMS HOMO SAPIENS homo sapiens Ely, K.R., Herron, J.N., Edmundson, A.B. 2.0 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 1vhp A NA 5 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5uk2 I i 0 E protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/17 CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 4 INFLUENZA A VIRUS; HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Liu, Y., Pan, J., Caradonna, T., Jenni, S., Raymond, D.D., Schmidt, A.G., Harrison, S.C., Grigorieff, N. 4.8 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 6x3t K L 0 D protein NA gamma-aminobutyric acid receptor subunit alpha-1 MEMBRANE PROTEIN 05/21/20 Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E. 2.55 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV6 Kappa None None None None None 6v7y F NA 0 A protein NA antigen-presenting glycoprotein cd1d IMMUNE SYSTEM 12/10/19 Human CD1d presenting alpha-Galactosylceramide in complex with VHH nanobody 1D5 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Shahine, A., Rossjohn, J. 2.4 X-RAY DIFFRACTION 0.276 0.241 False True IGHV1 NA NA None None None None None 7t3d C D 0 A protein NA hemagglutinin ha1 chain Viral Protein/IMMUNE SYSTEM 12/07/21 CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA INFLUENZA A VIRUS (A/CALIFORNIA/04/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009(h1n1)) Han, J., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 4xmk J N 0 R peptide hiv-1 jr-fl gp120 v3 peptide immune system/viral protein 01/14/15 Crystal structure of Fab of HIV-1 gp120 V3-specific human monoclonal antibody 2424 in complex with JR-FL V3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P., Pan, R. 3.179 X-RAY DIFFRACTION 0.283 0.225 False True IGHV3 IGKV2 Kappa None None None None None 6w1c K O 0 E protein NA e2 glycoprotein VIRUS/IMMUNE SYSTEM 03/04/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain MAYARO VIRUS (STRAIN BRAZIL); HOMO SAPIENS homo sapiens homo sapiens mayaro virus (strain brazil) Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 2kh2 B b 52 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5a2k H h 0 P peptide antigen tn, thr is covalently bound to galnac IMMUNE SYSTEM 05/20/15 Crystal structure of scFv-SM3 in complex with APD-TGalNAc-RP MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus homo sapiens Martinez-Saez, N., Castro-Lopez, J., Valero-Gonzalez, J., Madariaga, D., Companon, I., Somovilla, V.J., Salvado, M., Asensio, J.L., Jimenez-Barbero, J., Avenoza, A., Busto, J.H., Bernardes, G.J.L., Peregrina, J.M., Hurtado-Guerrero, R., Corzana, F. 1.7 X-RAY DIFFRACTION 0.21619 0.17583 True True unknown unknown unknown 4.5e-07 -8.658567314824953 Unknown TBD 7rth F E 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False True IGHV3 IGKV1 Kappa None None None None None 4rqq D C 0 IMMUNE SYSTEM 11/04/14 Crystal structure of human Fab PGDM1400, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.253 0.221 False True unknown IGKV2 Kappa None None None None None 6wps C D 0 B protein sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 05/27/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pinto, D., Park, Y.J., Beltramello, M., Walls, A.C., Tortorici, M.A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., De Marco, A., Peter, A., Guarino, B., Spreafico, R., Cameroni, E., Case, J.B., Chen, R.E., Havenar-Daughton, C., Snell, G., Virgin, H.W., Lanzavecchia, A., Diamond, M.S., Fink, K., Veesler, D., Corti, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 3ls4 H L 0 H Hapten TCI (6AR,10AR)-6,6,9-TRIMETHYL-3-PENTYL-6A,7,8,10A-TETRAHYDRO-6H-BENZO[C]CHROMEN-1-OL IMMUNE SYSTEM 02/12/10 Crystal Structure of Anti-tetrahydrocannabinol Fab Fragment in Complex with THC MUS MUSCULUS mus musculus mus musculus mus musculus Niemi, M.H., Rouvinen, J. 2.0 X-RAY DIFFRACTION 0.261 0.213 False True IGHV5 IGKV4 Kappa None None None None None 5mv3 I J 0 K peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 6m3c H L 0 A protein NA vitamin k-dependent protein c heavy chain BLOOD CLOTTING/IMMUNE SYSTEM 03/03/20 hAPC-h1573 Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wang, X., Wang, D., Zhao, X., Egner, U. 3.7 X-RAY DIFFRACTION 0.302 0.278 False True IGHV3 IGKV3 Kappa None None None None None 1bfo D C 0 ANTIBODY 05/20/98 CAMPATH-1G IGG2B RAT MONOCLONAL FAB RATTUS RATTUS rattus rattus rattus rattus Cheetham, G.M.T., Hale, G., Waldmann, H., Bloomer, A.C. 2.6 X-RAY DIFFRACTION 0.263 0.192 False False IGHV7 IGKV22 Kappa None None None None None 7lok M L 0 C protein NA envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/10/21 Structure of CD4 mimetic M48U1 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Jette, C.A., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7wwl I M 0 B protein NA spike glycoprotein VIRAL PROTEIN 02/13/22 S protein of Delta variant in complex with ZWD12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, Y.Y., Zhang, Y.Y., Zhou, Q. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4p2c G NA 0 B | A protein | protein NA | NA shiga toxin 2e, subunit b | shiga toxin 2e, subunit a TOXIN 03/03/14 Complex of Shiga toxin 2e with a neutralizing single-domain antibody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli | escherichia coli Lo, A.W.H., Moonens, K., De Kerpel, M., Brys, L., Pardon, E., Remaut, H., De Greve, H. 2.818 X-RAY DIFFRACTION 0.253 0.187 False True IGHV1 NA NA None None None None None 6a4k H L 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/20/18 Human antibody 32D6 Fab in complex with H1N1 influenza A virus HA1 INFLUENZA A VIRUS (A/CALIFORNIA/7/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/7/2009(h1n1)) Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 3.15 X-RAY DIFFRACTION 0.233 0.175 False True IGHV4 IGLV4 Lambda None None None None None 5f1k D NA 0 B protein adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 HYDROLASE/IMMUNE SYSTEM 11/30/15 human CD38 in complex with nanobody MU1053 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Zhang, H., Hao, Q. 2.3 X-RAY DIFFRACTION 0.231 0.198 False True IGHV1 None None None None None 5vxj F NA 0 E protein NA invasin ipad IMMUNE SYSTEM 05/23/17 2.50 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-E3 SHIGELLA FLEXNERI; VICUGNA PACOS vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.5 X-RAY DIFFRACTION 0.259 0.196 False True IGHV1 NA NA None None None None None 6w09 I M 0 E protein NA e2 glycoprotein VIRUS/IMMUNE SYSTEM 02/29/20 Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain CHIKUNGUNYA VIRUS; HOMO SAPIENS homo sapiens homo sapiens chikungunya virus Miller, A.S., Kuhn, R.J. 5.3 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 6u2f H L 0 A protein proprotein convertase subtilisin/kexin type 9 HYDROLASE/HYDROLASE INHIBITOR/IMMUNE SYSTEM 08/19/19 PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2 HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Ultsch, M.H., Kirchhofer, D. 2.94 X-RAY DIFFRACTION 0.209 0.174 False True IGHV1 IGKV6 Kappa None None None None None 5vxj J NA 0 I protein NA invasin ipad IMMUNE SYSTEM 05/23/17 2.50 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-E3 SHIGELLA FLEXNERI; VICUGNA PACOS vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.5 X-RAY DIFFRACTION 0.259 0.196 False True IGHV1 NA NA None None None None None 7e5s J T 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with four-antibody cocktail complex SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6y49 H L 0 L Hapten DEP DIETHYL PHOSPHONATE IMMUNE SYSTEM 02/19/20 Crystal structure of the paraoxon-modified A.17kappa antibody FAB fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chatziefthimiou, S., Mokrushina, Y., Smirnov, I., Gabibov, A., Wilmanns, M. 1.65 X-RAY DIFFRACTION 0.215 0.179 False True IGHV4 IGLV1 Lambda None None None None None 7pij N NA 0 B protein NA divalent metal cation transporter mnth MEMBRANE PROTEIN 08/20/21 Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA synthetic construct staphylococcus capitis Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7te4 B A 0 NA NA NA NA IMMUNE SYSTEM 01/04/22 Crystal structure of Fab2 anti-GluN2B antibody MUS MUSCULUS mus musculus mus musculus Tajima, N., Furukawa, H. 2.456 X-RAY DIFFRACTION 0.297 0.261 False False IGHV5 IGKV19 Kappa None None None None None 6x03 D NA 0 NA NA NA NA STRUCTURAL PROTEIN 05/15/20 Nup84-Nup133 (aa521-1157) from S. cerevisiae bound by VHH-SAN8 and VHH-SAN9 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos Nordeen, S.A., Schwartz, T.U. 7.3 X-RAY DIFFRACTION 0.353 0.335 False True IGHV1 NA NA None None None None None 7lu9 q r 0 d protein NA unknown VIRAL PROTEIN/IMMUNE SYSTEM 02/21/21 Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1 macaca mulatta macaca mulatta human immunodeficiency virus 1 Manne, K., Edwards, R.J., Acharya, P. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV2 IGLV2 Lambda None None None None None 7ow1 H K 0 A peptide NA amyloid-beta precursor protein IMMUNE SYSTEM 06/16/21 Crystal Structure of TAP01 in complex with amyloid beta peptide Homo sapiens; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Hall, G., Cowan, R., Carr, M.D. 1.4 X-RAY DIFFRACTION 0.200 0.152 False True IGHV2 IGKV10 Kappa None None None None None 3b9k D C 0 F protein t-cell surface glycoprotein cd8 beta chain IMMUNE SYSTEM 11/05/07 Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB MUS MUSCULUS; RATTUS RATTUS rattus rattus rattus rattus mus musculus Shore, D., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.284 0.235 False False IGHV2 IGKV19 Kappa None None None None None 1yuh B A 0 B Hapten NP 4-HYDROXY-3-NITROPHENYLACETYL-EPSILON-AMINOCAPROIC ACID IMMUNOGLOBULIN 01/30/96 FAB FRAGMENT MUS MUSCULUS mus musculus Yuhasz, S.C., Amzel, L.M., Parry, C., Strand, M. 3.0 X-RAY DIFFRACTION unknown 0.190 False True IGHV1 IGLV1 Lambda None None None None None 4msw A B 0 C protein ph-gated potassium channel kcsa TRANSPORT PROTEIN 09/18/13 Y78 ester mutant of KcsA in high K+ STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Matulef, K., Valiyaveetil, F.I. 2.06 X-RAY DIFFRACTION 0.229 0.196 False True IGHV1 IGKV5 Kappa None None None None None 4lf3 E D 0 F protein glucagon receptor IMMUNE SYSTEM 06/26/13 Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Murray, J.M., Mukund, S. 2.735 X-RAY DIFFRACTION 0.264 0.209 False True IGHV3 IGKV1 Kappa None None None None None 4z0x B A 0 C peptide hcv e2 antigen (residues 432-446) IMMUNE SYSTEM 03/26/15 Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Rangarajan, S., Mariuzza, R.A. 2.0 X-RAY DIFFRACTION 0.270 0.226 False True IGHV1 IGLV3 Lambda None None None None None 2ghw B b 0 A protein spike glycoprotein VIRUS/VIRAL PROTEIN/ANTIBIOTIC 03/27/06 Crystal structure of SARS spike protein receptor binding domain in complex with a neutralizing antibody, 80R SARS CORONAVIRUS; HOMO SAPIENS homo sapiens sars coronavirus Hwang, W.C., Lin, Y., Santelli, E., Sui, J., Jaroszewski, L., Stec, B., Farzan, M., Marasco, W.A., Liddington, R.C. 2.3 X-RAY DIFFRACTION 0.295 0.248 True True unknown unknown unknown None None None None None 3wbd A a 0 IMMUNE SYSTEM 05/14/13 Crystal structure of anti-polysialic acid antibody single chain Fv fragment (mAb735) complexed with octasialic acid SYNTHETIC CONSTRUCT synthetic construct Nagae, M., Ikeda, A., Hanashima, S., Kitajima, K., Sato, C., Yamaguchi, Y. 1.8 X-RAY DIFFRACTION 0.259 0.233 True True unknown unknown unknown None None None None None 2ajz H L 0 L Hapten ECG 3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER IMMUNE SYSTEM 08/02/05 Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.285 0.238 False False IGHV3 IGKV2 Kappa None None None None None 7qnx H L 0 E protein NA surface glycoprotein VIRAL PROTEIN 12/23/21 The receptor binding domain of SARS-CoV-2 spike glycoprotein in complex with Beta-55 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.92 X-RAY DIFFRACTION 0.266 0.229 False True IGHV3 IGKV1 Kappa None None None None None 7fim N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 07/31/21 Cryo-EM structure of the tirzepatide (LY3298176)-bound human GLP-1R-Gs complex SYNTHETIC CONSTRUCT; RATTUS NORVEGICUS; BOS TAURUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus Zhao, F.H., Zhou, Q.T., Cong, Z.T., Hang, K.N., Zou, X.Y., Zhang, C., Chen, Y., Dai, A.T., Liang, A.Y., Ming, Q.Q., Wang, M., Chen, L.N., Xu, P.Y., Chang, R.L., Feng, W.B., Xia, T., Zhang, Y., Wu, B.L., Yang, D.H., Zhao, L.H., Xu, H.E., Wang, M.W. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5anm B A 0 G protein ig epsilon chain c region 09/07/15 Crystal structure of IgE Fc in complex with a neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Cohen, E.S., Dobson, C.L., Kack, H., Wang, B., Sims, D.A., Lloyd, C.O., England, E., Rees, D.G., Guo, H., Karagiannis, S.N., O'Brien, S., Persdotter, S., Ekdahl, H., Butler, R., Keyes, F., Oakley, S., Carlsson, M., Briend, E., Wilkinson, T., Anderson, I.K., Monk, P.D., vonWachenfeldt, K., Eriksson, P.O., Gould, H.J., Vaughan, T.J., May, R.D. 2.85 X-RAY DIFFRACTION 0.25993 0.19553 False True IGHV1 IGLV1 Lambda 1.95e-12 -15.975251068647337 Kinetic Exclusion Assay TBD 1lo0 H L 0 H Hapten BC1 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID IMMUNE SYSTEM 05/05/02 Catalytic Retro-Diels-Alderase Transition State Analogue Complex MUS MUSCULUS mus musculus mus musculus mus musculus Hugot, M., Reymond, J.L., Baumann, U. 2.0 X-RAY DIFFRACTION 0.255 0.206 False False IGHV5 IGKV1 Kappa None None None None None 7e23 B C 0 A protein NA spike protein s1 VIRAL PROTEIN 02/04/21 SARS-CoV-2 spike in complex with the CA521 neutralizing antibody Fab (focused refinement on Fab-RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, C., Song, D., Dou, C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7sfv O P 0 E protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 5mp3 H L 0 D peptide microtubule-associated protein IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.75 X-RAY DIFFRACTION 0.250 0.199 False False IGHV1 IGKV8 Kappa None None None None None 3ley H L 0 P peptide envelope glycoprotein gp41 IMMUNE SYSTEM 01/15/10 2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 6a7 in complex with HIV-1 GP41 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Wyatt, R., Kwong, P.D. 1.99 X-RAY DIFFRACTION 0.215 0.177 False False IGHV3 IGKV1 Kappa None None None None None 7s3i N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 09/07/21 Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 2) HOMO SAPIENS homo sapiens homo sapiens | homo sapiens | homo sapiens Belousoff, M.J., Piper, S.J., Danev, R. 2.51 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6e9i H L 0 IMMUNE SYSTEM 08/01/18 The crystal structure of bovine ultralong antibody BOV-4 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 2.5 X-RAY DIFFRACTION 0.243 0.202 False True IGHV1 IGLV1 Lambda None None None None None 5e94 D C 0 H protein glucagon-like peptide 1 receptor MEMBRANE PROTEIN 10/14/15 Antibody-bound Glucagon-like Peptide-1 receptor extracellular domain MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Soroka, V., Schluckebier, G., Reedtz-Runge, S. 2.0 X-RAY DIFFRACTION 0.232 0.188 False True IGHV3 IGKV10 Kappa None None None None None 1rzi F E 0 IMMUNE SYSTEM 12/24/03 Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.9 X-RAY DIFFRACTION 0.321 0.233 False True IGHV1 IGKV1 Kappa None None None None None 7lmp NA A 0 B Hapten NY6 3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-8-(1~{H}-imidazol-5-ylcarbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione IMMUNE SYSTEM 02/05/21 Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 36 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-8-(1H-imidazole-4-carbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.29 X-RAY DIFFRACTION 0.264 0.203 False True NA IGLV6 Lambda None None None None None 5boz K NA 0 E protein ricin Hydrolase/Immune system 05/27/15 Ricin A chain bound to camelid nanobody (VHH9)(E1) RICINUS COMMUNIS; LAMA GLAMA lama glama ricinus communis Rudolph, M.J., Mantis, N. 3.1 X-RAY DIFFRACTION 0.277 0.215 False True IGHV1 7e-10 -12.489520888040902 SPR TBD 5t33 H L 0 G protein rhpa gp120 core IMMUNE SYSTEM 08/24/16 Crystal structure of strain-specific glycan-dependent CD4 binding site-directed neutralizing antibody CAP257-RH1, in complex with HIV-1 strain RHPA gp120 core with an oligomannose N276 glycan. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Wibmer, C.K., Gorman, J., Kwong, P.D. 3.2092 X-RAY DIFFRACTION 0.269 0.229 False True IGHV3 IGLV3 Lambda None None None None None 3mlx H L 0 P peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with an MN V3 peptide HOMO SAPIENS; HIV-1 M:B_MN homo sapiens homo sapiens hiv-1 m Kong, X.-P. 1.9 X-RAY DIFFRACTION 0.228 0.192 False False IGHV4 IGLV1 Lambda None None None None None 6xxn C NA 0 ANTITUMOR PROTEIN 06/10/20 Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen CAMELUS DROMEDARIUS camelus dromedarius Shahar, A., Rosenfeld, L., Papo, N. 2.65 X-RAY DIFFRACTION 0.231 0.182 False True IGHV1 None None None None None 4hg4 J K 0 A protein hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 6med C D 0 IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 2.04 X-RAY DIFFRACTION 0.216 0.182 False True IGHV1 IGKV1 Kappa None None None None None 4z5r S R 0 H protein interferon alpha-2 Cytokine/Immune System 04/02/15 Rontalizumab Fab bound to Interferon-a2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eigenbrot, C., Maurer, B., Bosanac, I. 3.0 X-RAY DIFFRACTION 0.251 0.223 False True IGHV3 IGKV1 Kappa 1.8e-11 -14.658430977236662 SPR TBD 5njd X W 0 E | H protein | protein NA | NA interleukin-12 subunit beta | interleukin-23 subunit alpha IMMUNE SYSTEM 03/28/17 Structure of Interleukin 23 in complex with Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Bloch, Y., Savvides, S.N. 3.9 X-RAY DIFFRACTION 0.312 0.272 False True IGHV3 IGLV1 Lambda None None None None None 1qlr B A 0 IMMUNOGLOBULIN 09/11/99 CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A HUMAN MONOCLONAL IgM COLD AGGLUTININ HOMO SAPIENS homo sapiens homo sapiens Carvalho, J.G., Cauerhff, A., Goldbaum, F., Leoni, J., Polikarpov, I. 2.83 X-RAY DIFFRACTION 0.265 0.216 False False IGHV4 IGKV3D Kappa None None None None None 4mau H L 0 IMMUNE SYSTEM 08/16/13 Crystal structure of anti-ST2L antibody C2244 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 1.9 X-RAY DIFFRACTION 0.217 0.184 False True IGHV3 IGKV3 Kappa None None None None None 7ncs H L 0 A protein NA outer membrane protein assembly factor bama MEMBRANE PROTEIN 01/29/21 Lateral-open conformation of the lid-locked BAM complex (BamA E435C S665C, BamBDCE) bound by a bactericidal Fab fragment ESCHERICHIA COLI K-12; HOMO SAPIENS homo sapiens homo sapiens escherichia coli k-12 Haysom, S.F., Machin, J.M. 7.1 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV12 Kappa None None None None None 7l7e O P 0 K protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 3.0 X-RAY DIFFRACTION 0.273 0.215 False True IGHV3 IGKV4 Kappa None None None None None 6mpg 8 7 0 2 protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6shg H L 0 B protein NA roab13 fab heavy chain (constant domain) IMMUNE SYSTEM 08/06/19 Diffraction data for RoAb13 crystal co-crystallised with PIYDIN and its RoAb13 structure MUS MUSCULUS mus musculus mus musculus mus musculus Saridakis, E., Helliwell, J.R., Govada, L., Chain, B., Morgan, M., Kassen, S.C., Chayen, N.E. 3.093 X-RAY DIFFRACTION 0.325 0.270 False True IGHV5 IGKV8 Kappa None None None None None 5uqy H G 0 E | J protein | protein NA | NA envelope glycoprotein gp1 | envelope glycoprotein gp2 VIRAL PROTEIN/IMMUNE SYSTEM 02/08/17 Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 LAKE VICTORIA MARBURGVIRUS (STRAIN RAVN-87); HOMO SAPIENS homo sapiens homo sapiens lake victoria marburgvirus (strain ravn-87) | lake victoria marburgvirus (strain ravn-87) Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O. 3.6 X-RAY DIFFRACTION 0.262 0.221 False False IGHV4 IGKV1 Kappa None None None None None 6pci H K 0 A protein NA virion spike glycoprotein immune system, viral protein 06/17/19 EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs EBOLA VIRUS; HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens ebola virus Ward, A.B., Murin, C.D., Alkutkar, T. 4.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6z20 B NA 0 A protein NA cd9 antigen CELL ADHESION 05/14/20 Structure of the EC2 domain of CD9 in complex with nanobody 4C8 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Oosterheert, W., Manshande, J., Pearce, N.M., Lutz, M., Gros, P. 2.68 X-RAY DIFFRACTION 0.248 0.206 False True IGHV1 NA NA None None None None None 6vlr E M 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/24/20 BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 4.42 ELECTRON MICROSCOPY NA NA False True IGHV4 IGLV3 Lambda None None None None None 5ovw J NA 0 D protein vitamin b12-binding protein TRANSPORT PROTEIN 08/30/17 Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Mireku, S.A., Sauer, M.M., Glockshuber, R., Locher, K.P. 2.653 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 None None None None None 2vyr F NA 0 B protein mdm4 protein IMMUNE SYSTEM 07/28/08 Structure of human MDM4 N-terminal domain bound to a single domain antibody HOMO SAPIENS homo sapiens homo sapiens Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R. 2.0 X-RAY DIFFRACTION 0.248 0.207 False True IGHV3 4.40e-08 -9.69 ITC 15 19084022 5e03 A NA 0 SIGNALING PROTEIN 09/28/15 Crystal structure of mouse CTLA-4 nanobody MUS MUSCULUS mus musculus Fedorov, A.A., Fedorov, E.V., Samanta, D., Almo, S.C. 1.685 X-RAY DIFFRACTION 0.189 0.171 False True IGHV1 None None None None None 6vi1 H G 0 P peptide NA terminase, large subunit IMMUNE SYSTEM 01/11/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 2.4 X-RAY DIFFRACTION 0.239 0.189 False True IGHV3 IGKV1 Kappa None None None None None 4gag H L 0 P peptide genome polyprotein IMMUNE SYSTEM 07/25/12 Structure of the broadly neutralizing antibody AP33 in complex with its HCV epitope (E2 residues 412-423) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus hepatitis c virus (isolate glasgow) Potter, J.A., Owsianka, A., Angus, A.G.N., Jeffery, N., Matthews, D., Keck, Z., Lau, P., Foung, S.K.H., Taylor, G.L., Patel, A.H. 1.8 X-RAY DIFFRACTION 0.211 0.178 False False IGHV3 IGKV3 Kappa None None None None None 3grw H L 0 A protein fibroblast growth factor receptor 3 TRANSFERASE/IMMUNE SYSTEM 03/26/09 FGFR3 in complex with a Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 2.1 X-RAY DIFFRACTION 0.228 0.189 False True IGHV3 IGKV1 Kappa None None None None None 7k8r H L 0 NA NA NA NA IMMUNE SYSTEM 09/27/20 Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C135 HOMO SAPIENS homo sapiens homo sapiens Jette, C.A., Barnes, C.O., Bjorkman, P.J. 2.0 X-RAY DIFFRACTION 0.237 0.195 False True IGHV3 IGKV1 Kappa None None None None None 4k07 NA F 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 6vja I M 0 D protein b-lymphocyte antigen cd20 IMMUNE SYSTEM 01/15/20 Structure of CD20 in complex with rituximab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rohou, A., Croll, T.I. 3.3 ELECTRON MICROSCOPY False True IGHV1 IGKV4 Kappa None None None None None 7pc2 M N 0 C protein NA gp120, bg505 sosip.664 t332n VIRAL PROTEIN 08/03/21 HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Fernandez, I., Bontems, F., Pehau-Arnaudet, G., Rey, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6z3k J K 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 7ra8 F G 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/30/21 SARS-CoV-2 S glycoprotein in complex with S2X259 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Veesler, D., Tortorici, M.A., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7mzk N M 0 B protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 96 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.25 X-RAY DIFFRACTION 0.235 0.197 False True IGHV1 IGKV4 Kappa None None None None None 5zia K M 0 N peptide phosphorylated tau peptide IMMUNE SYSTEM 03/14/18 Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, H., Wilson, I.A. 2.603 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 IGKV4 Kappa 3e-07 -8.898798774188476 Unknown TBD 6bt3 F E 0 L protein NA major capsid protein l1 VIRUS 12/05/17 High-Resolution Structure Analysis of Antibody V5 Conformational Epitope on Human Papillomavirus 16 MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 Guan, J., Bywaters, S.M., Brendle, S.A., Ashley, R.E., Makhov, A.M., Conway, J.F., Christensen, N.D., Hafenstein, S. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 5m7q B NA 0 IMMUNE SYSTEM 10/28/16 Engineering the Thermostability of Nanobodies - NbD2 CAMELUS DROMEDARIUS camelus dromedarius Soler, N., Kunz, P., Muyldermans, S. 1.8 X-RAY DIFFRACTION 0.249 0.196 False True IGHV1 None None None None None 5cex B A 0 IMMUNE SYSTEM 07/07/15 Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies HOMO SAPIENS homo sapiens homo sapiens Garces, F., Wilson, I.A. 2.105 X-RAY DIFFRACTION 0.244 0.200 False True IGHV4 IGLV3 Lambda None None None None None 5wn9 H h 0 A peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 07/31/17 Structure of antibody 2D10 bound to the central conserved region of RSV G HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens human respiratory syncytial virus a (straina2) Fedechkin, S.O., George, N.L., Wolff, J.T., Kauvar, L.M., DuBois, R.M. 1.551 X-RAY DIFFRACTION 0.185 0.169 True True unknown unknown unknown None None None None None 3ivk H L 0 M nucleic-acid class i ligase product immune system / RNA 09/01/09 Crystal Structure of the Catalytic Core of an RNA Polymerase Ribozyme Complexed with an Antigen Binding Antibody Fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Koldobskaya, Y., Duguid, E.M., Shechner, D.M., Koide, S., Kossiakoff, A.A., Bartel, D.P., Piccirilli, J.A. 3.1 X-RAY DIFFRACTION 0.225 0.207 False True IGHV5 IGKV15 Kappa None None None None None 5vsh A B 0 IMMUNE SYSTEM 05/11/17 CH1/Clambda Fab based on Pertuzumab HOMO SAPIENS homo sapiens homo sapiens Hendle, J. 2.55 X-RAY DIFFRACTION 0.255 0.207 False True IGHV3 IGKV1 Kappa None None None None None 2ny4 D C 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 11/20/06 HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E268C, S334A, S375W) Complexed with CD4 and Antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Xu, L., Dey, B., Hessell, A.J., Van Ryk, D., Xiang, S.H., Yang, X., Zhang, M.Y., Zwick, M.B., Arthos, J., Burton, D.R., Dimitrov, D.S., Sodroski, J., Wyatt, R., Nabel, G.J., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.241 0.202 False True IGHV1 IGKV3 Kappa 4.42e-07 SPR 17301785 6bfs H L 0 C protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 10/26/17 The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W. 2.0 X-RAY DIFFRACTION 0.248 0.182 False True IGHV1 IGKV15 Kappa None None None None None 6hf1 F E 0 D protein sulfhydryl oxidase 1 OXIDOREDUCTASE 08/21/18 Mutant oxidoreductase fragment of mouse QSOX1 in complex with an antibody Fab MUS MUSCULUS mus musculus mus musculus mus musculus Grossman-Haham, I., Fass, D. 1.94 X-RAY DIFFRACTION 0.231 0.194 False True IGHV1 IGKV4 Kappa None None None None None 6lht H L 0 C | A | B | E | D protein | protein | protein | protein | protein NA | NA | NA | NA | NA vp1 protein | vp1 protein | vp1 protein | vp1 protein | vp1 protein VIRAL PROTEIN 12/10/19 Localized reconstruction of coxsackievirus A16 mature virion in complex with Fab 18A7 MUS MUSCULUS; COXSACKIEVIRUS A16 mus musculus mus musculus coxsackievirus a16 | coxsackievirus a16 | coxsackievirus a16 | coxsackievirus a16 | coxsackievirus a16 He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W. 3.67 ELECTRON MICROSCOPY False False IGHV1 IGKV8 Kappa None None None None None 7jum H h 0 A protein NA gametocyte surface protein p230 CELL INVASION 08/20/20 Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01 PLASMODIUM FALCIPARUM (ISOLATE 3D7); HOMO SAPIENS homo sapiens plasmodium falciparum (isolate 3d7) Tolia, N., Tang, W.K. 1.998 X-RAY DIFFRACTION 0.233 0.191 True True unknown unknown unknown None None None None None 2yc1 D E 0 F protein beta-mammal toxin cn2 IMMUNE SYSTEM/TOXIN 03/10/11 Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann HOMO SAPIENS; CENTRUROIDES NOXIUS HOFFMANN homo sapiens homo sapiens centruroides noxius hoffmann Canul-Tec, J.C., Riano-Umbarila, L., Rudino-Pinera, E., Becerril, B., Possani, L.D., Torres-Larios, A. 1.9 X-RAY DIFFRACTION 0.21212 0.18613 False True IGHV3 IGKV3 Kappa None None None None None 4odw A B 0 IMMUNE SYSTEM 01/10/14 Unliganded Fab structure of lipid A-specific antibody A6 MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.72 X-RAY DIFFRACTION 0.257 0.231 False False IGHV5 IGKV10 Kappa None None None None None 5jym B b 0 A protein cadherin-3 CELL ADHESION/IMMUNE SYSTEM 05/14/16 Human P-cadherin EC12 with scFv TSP11 bound HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Caaveiro, J.M.M., Kudo, S., Tsumoto, K. 2.45 X-RAY DIFFRACTION 0.270 0.223 True True unknown unknown unknown None None None None None 3k80 A NA 0 C protein mp18 rna editing complex protein Immune System, RNA Binding Protein 10/13/09 Structure of essential protein from Trypanosoma brucei LAMA GLAMA; TRYPANOSOMA BRUCEI lama glama trypanosoma brucei Wu, M. 2.4 X-RAY DIFFRACTION 0.277 0.223 False True IGHV1 None None None None None 3bsz H L 0 F protein plasma retinol-binding protein TRANSPORT PROTEIN/IMMUNE SYSTEM 12/27/07 Crystal structure of the transthyretin-retinol binding protein-Fab complex HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Zanotti, G., Cendron, L., Gliubich, F., Folli, C., Berni, R. 3.38 X-RAY DIFFRACTION 0.312 0.239 False True IGHV1 IGKV3 Kappa None None None None None 5kan G I 0 D | E protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.g.07 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.785 X-RAY DIFFRACTION 0.243 0.218 False True IGHV1 IGKV1 Kappa None None None None None 4xbp H L 0 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylethanolamine (06:0 PE) HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.94 X-RAY DIFFRACTION 0.271 0.228 False True IGHV1 IGKV3 Kappa None None None None None 3wih I M 0 B protein roundabout homolog 1 IMMUNE SYSTEM 09/12/13 Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A. HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nakayama, T., Mizohata, E., Yamashita, T., Nagatoishi, M., Iwanari, H., Mochizuki, Y., Kado, Y., Yokota, Y., Sato, R., Tsumoto, K., Fujitani, H., Kodama, T., Hamakubo, T., Inoue, T. 1.701 X-RAY DIFFRACTION 0.236 0.189 False False IGHV1 IGKV10 Kappa 1.9e-08 -10.533664762780313 ITC TBD 4tnw J M 0 E protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 06/05/14 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Althoff, T., Hibbs, R.E., Banerjee, S., Gouaux, E. 3.2 X-RAY DIFFRACTION 0.251 0.227 False False IGHV1 IGLV1 Lambda None None None None None 7mhr A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 04/15/21 KcsA E71V closed gate with K+ MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Rohaim, A., Li, J., Weingarth, M., Roux, B. 2.77 X-RAY DIFFRACTION 0.203 0.168 False True IGHV1 IGKV5 Kappa None None None None None 5ock H L 0 A peptide cep1 peptide (from enolase) IMMUNE SYSTEM 07/03/17 Crystal structure of ACPA E4 in complex with CEP1 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Dobritzsch, D., Ge, C., Holmdahl, R. 1.6 X-RAY DIFFRACTION 0.218 0.183 False True IGHV4 IGLV1 Lambda None None None None None 6fg1 A D 0 IMMUNE SYSTEM 01/09/18 CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA32. HOMO SAPIENS homo sapiens homo sapiens Bertrand, T., Pouzieux, S. 2.03 X-RAY DIFFRACTION 0.285 0.266 False True IGHV1 IGKV3 Kappa None None None None None 4uu9 A B 0 C protein complement c5 07/25/14 Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Colley, C., Sridharan, S., Dobson, C., Popovic, B., Debreczeni, J.E., Hargreaves, D., Edwards, B., Brennan, J., England, L., Fung, S., An Eghobamien, L., Sivars, U., Woods, R., Flavell, L., Renshaw, G.J., Wickson, K., Wilkinson, T., Davies, R., Bonnell, J., Warrener, P., Howes, R., Vaughan, T. 2.12 X-RAY DIFFRACTION 0.20163 0.17456 False True IGHV3 IGLV2 Lambda 1.4e-11 -14.80733067454163 SPR TBD 7kqk A B 0 C peptide NA ptau peptide IMMUNE SYSTEM 11/16/20 anti-pTau C21-ABS Fab in complex with pTau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Mosyak, L., Brinth, A. 2.6 X-RAY DIFFRACTION 0.231 0.211 False True IGHV3 IGLV3 Lambda None None None None None 6gjq H NA 0 G protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/16/18 human NBD1 of CFTR in complex with nanobody T27 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.49 X-RAY DIFFRACTION 0.240 0.199 False True IGHV1 None None None None None 3j8z F J 0 D protein NA l1 VIRUS/IMMUNE SYSTEM 11/20/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 14 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 6qna H L 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV hybrid Fab B13HC-B4LC BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.62 X-RAY DIFFRACTION 0.250 0.220 False True IGHV1 IGLV1 Lambda None None None None None 7f4h S s 0 A | G protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 06/18/21 Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein, Nb35 and scFv16 HOMO SAPIENS; SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | homo sapiens Ma, S., Chen, Y., Dai, A., Yin, W., Guo, J., Yang, D., Zhou, F., Jiang, Y., Wang, M.-W., Xu, H.E. 2.7 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6ey6 P NA 0 H protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 5t6p B A 0 F peptide muc1 peptide fragment IMMUNE SYSTEM 09/01/16 Crystal structure of therapeutic mAB AR20.5 in complex with MUC1 peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Brooks, C.L., Movahedin, M. 1.97 X-RAY DIFFRACTION 0.232 0.221 False True IGHV5 IGKV1 Kappa 8.8e-07 -8.26120372284051 Unknown TBD 7lf2 P N 0 Q protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb4 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.72 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 2x1q B NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama VandenAbbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., VanLoo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.06 X-RAY DIFFRACTION 0.229 0.213 False True IGHV1 None None None None None 1zvh A NA 0 L protein NA lysozyme c HYDROLASE/IMMUNE SYSTEM 06/02/05 Crystal structure of the VHH domain D2-L24 in complex with hen egg white lysozyme CAMELUS DROMEDARIUS; GALLUS GALLUS camelus dromedarius gallus gallus De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., Wyns, L. 1.5 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 NA NA None None None None None 7tzh A a 0 B protein NA lymphocyte activation gene 3 protein IMMUNOSUPPRESSANT 02/15/22 LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition HOMO SAPIENS homo sapiens homo sapiens Ming, Q., Tran, T.H., Luca, V.C. 2.43 X-RAY DIFFRACTION 0.255 0.212 True True unknown unknown unknown None None None None None 3ggw D C 0 F peptide peptide b1 IMMUNE SYSTEM 03/02/09 Crystal Structure of FAB F22-4 in complex with a Carbohydrate-mimetic peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Saul, F.A., Vulliez-Le Normand, B., Bentley, G.A. 1.7 X-RAY DIFFRACTION 0.245 0.197 False False IGHV6 IGKV2 Kappa 2.90e-06 -7.55 ITC 25 19328810 4jn1 H L 0 immune system 03/14/13 An Antidote for Dabigatran MUS MUSCULUS mus musculus mus musculus Schiele, F., Nar, H. 1.89 X-RAY DIFFRACTION 0.197 0.176 False True IGHV4 IGKV2 Kappa None None None None None 7tyx N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/14/22 Human Amylin2 Receptor in complex with Gs and rat amylin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 2.55 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7d85 E F 0 D protein NA receptor tyrosine-protein kinase erbb-3 IMMUNE SYSTEM 10/07/20 Crystal structure of anti-ErbB3 Fab ISU104 in complex with human ErbB3 extracellular domain 3 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yoo, Y., Cho, H.S. 2.5 X-RAY DIFFRACTION 0.258 0.203 False True IGHV3 IGLV1 Lambda None None None None None 2rcj I L 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 7mk6 A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 04/21/21 KcsA open gate E71V mutant with sodium SYNTHETIC CONSTRUCT; STREPTOMYCES LIVIDANS synthetic construct synthetic construct streptomyces lividans Rohaim, A., Li, J., Weingarth, M., Roux, B. 3.1 X-RAY DIFFRACTION 0.253 0.208 False True IGHV3 IGKV1 Kappa None None None None None 3q6f L K 0 IMMUNE SYSTEM 12/31/10 Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B., Sampson, J., Totrov, M., Li, H., O'Neal, T., William, C., Robinson, J., Gorny, M.K., Zolla-Pazner, S., Kong, X.P. 3.192 X-RAY DIFFRACTION 0.243 0.199 False False IGHV3 IGLV3 Lambda None None None None None 5gs2 D d 0 B protein repebody SUGAR BINDING PROTEIN/IMMUNE SYSTEM 08/13/16 Crystal structure of diabody complex with repebody and MBP MUS MUSCULUS; HOMO SAPIENS; ESCHERICHIA COLI (STRAIN K12); ESCHERICHIA COLI mus musculus escherichia coli Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 3.592 X-RAY DIFFRACTION 0.278 0.217 True True unknown unknown unknown None None None None None 3qg6 B A 0 D peptide agr autoinducing peptide IMMUNE SYSTEM/INHIBITOR 01/24/11 Structural Basis for Ligand Recognition and Discrimination of a Quorum Quenching Antibody MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kirchdoerfer, R.N., Janda, J.D., Kaufmann, G.F, Wilson, I.A 2.5 X-RAY DIFFRACTION 0.239 0.184 False True IGHV3 IGKV1 Kappa None None None None None 2kqn NA B 15 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7u8m F E 0 D protein NA hemagglutinin ha2 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 5.39 X-RAY DIFFRACTION 0.342 0.304 False True IGHV3 IGKV3 Kappa None None None None None 6tcs A a 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab scFv HOMO SAPIENS homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 2.3 X-RAY DIFFRACTION 0.206 0.178 True True unknown unknown unknown None None None None None 1ikf H L 0 C peptide cyclosporin a IMMUNE SYSTEM/IMMUNOSUPPRESSANT 12/09/93 A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens tolypocladium inflatum Vix, O., Altschuh, D., Rees, B., Thierry, J.-C. 2.5 X-RAY DIFFRACTION unknown 0.164 False True IGHV5 IGKV10 Kappa None None None None None 6ada E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148D mutant CLC-ec1 in 200mM bromide ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 3.153 X-RAY DIFFRACTION 0.290 0.231 False False IGHV4 IGKV4 Kappa None None None None None 6cue 3 4 0 1 protein envelope glycoprotein gp41 VIRAL PROTEIN 03/26/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus human immunodeficiency virus 1 Acharya, P., Carragher, B., Potter, C.S., Kwong, P.D. 4.0 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7kkl B NA 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/20 SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 2.85 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5u7m D E 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN/Immune system 12/12/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer bound to small molecule HIV-1 entry inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 A. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Lai, Y.-T., Kwong, P.D. 3.025 X-RAY DIFFRACTION 0.289 0.245 False True unknown unknown unknown 1.8000000000000002e-07 -9.201454619595646 Unknown TBD 6phc C D 0 E protein 25 kda ookinete surface antigen IMMUNE SYSTEM 06/25/19 Pfs25 in complex with the human transmission blocking antibody 2544 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum McLeod, B.R., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.238 0.200 False True IGHV3 IGKV2 Kappa None None None None None 6vy6 H L 0 A protein NA receptor binding protein VIRAL PROTEIN/IMMUNE SYSTEM 02/25/20 Crystal structure of Hendra receptor binding protein head domain in complex with human neutralizing antibody HENV-26 HENDRA HENIPAVIRUS; HOMO SAPIENS homo sapiens homo sapiens hendra henipavirus Dong, J., Crowe, J.E. 2.6 X-RAY DIFFRACTION 0.247 0.197 False True IGHV3 IGLV3 Lambda None None None None None 7ek0 H L 0 R protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 04/03/21 Complex Structure of antibody BD-503 and RBD-N501Y of COVID-19 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Xu, H., Wang, B., Zhao, T.N., Su, X.D. 2.7 X-RAY DIFFRACTION 0.266 0.214 False True IGHV3 IGKV1 Kappa None None None None None 5f1k C NA 0 A protein adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 HYDROLASE/IMMUNE SYSTEM 11/30/15 human CD38 in complex with nanobody MU1053 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Zhang, H., Hao, Q. 2.3 X-RAY DIFFRACTION 0.231 0.198 False True IGHV1 None None None None None 5lz0 A NA 0 IMMUNE SYSTEM 09/29/16 Llama nanobody PorM_01 LAMA GLAMA lama glama Duhoo, Y., Leone, P., Roussel, A. 1.6 X-RAY DIFFRACTION 0.232 0.203 False True IGHV1 None None None None None 4w6y B NA 0 A protein f18 fimbrial adhesin ac CELL ADHESION 08/21/14 Co-complex structure of the lectin domain of F18 fimbrial adhesin FedF with inhibitory nanobody NbFedF9 ESCHERICHIA COLI DH5[ALPHA]; LAMA GLAMA lama glama escherichia coli dh5[alpha] Moonens, K., De Kerpel, M., Coddens, A., Cox, E., Pardon, E., Remaut, H., De Greve, H. 1.57 X-RAY DIFFRACTION 0.226 0.195 False True IGHV1 1.5800000000000001e-09 -12.007180047995258 SPR TBD 4evn A B 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 7n9c D NA 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/17/21 Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB95 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Sun, D., Zhang, C., Shi, Y. 3.71 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7f12 B b 0 A protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 06/07/21 A SARS-CoV-2 neutralizing antibody SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Zhang, G., Li, X., Guo, Y., Wang, Y., Yuan, S. 3.15 X-RAY DIFFRACTION 0.245 0.195 True True unknown unknown unknown None None None None None 7e8m H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/02/21 Crystal structure of SARS-CoV-2 antibody P2C-1F11 with mutated RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X.Q., Zhang, L.Q., Ge, J.W., Wang, R.K., Lan, J. 2.09 X-RAY DIFFRACTION 0.199 0.169 False True IGHV3 IGKV3 Kappa None None None None None 3jbg 7 NA 0 VIRUS/IMMUNE SYSTEM 08/26/15 Complex of poliovirus with VHH PVSS21E CAMELUS DROMEDARIUS; HUMAN POLIOVIRUS 1 MAHONEY camelus dromedarius Strauss, M., Schotte, L., Thys, B., Filman, D.J., Hogle, J.M. 3.8 ELECTRON MICROSCOPY False True IGHV1 None None None None None 4f33 D C 0 IMMUNE SYSTEM 05/08/12 Crystal Structure of therapeutic antibody MORAb-009 MUS MUSCULUS Xia, D., Ma, J., Tang, W.K., Esser, L. 1.749 X-RAY DIFFRACTION 0.234 0.208 False True IGHV1 IGKV4 Kappa None None None None None 4kkl E F 0 B protein h(+)/cl(-) exchange transporter clca tranport protein, membrane protein 05/06/13 Structure of the E148A mutant of CLC-ec1 delta NC construct in 100mM fluoride MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Stockbridge, R.B., Lim, H.-H., Miller, C. 2.85 X-RAY DIFFRACTION 0.290 0.248 False True IGHV4 IGKV4 Kappa None None None None None 1aif B A 0 IMMUNOGLOBULIN 11/14/94 ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A) FAB FROM MOUSE MUS MUSCULUS mus musculus mus musculus Ban, N., Escobar, C., Hasel, K., Day, J., Greenwood, A., McPherson, A. 2.9 X-RAY DIFFRACTION unknown 0.220 False False IGHV6 IGKV4 Kappa None None None None None 6oq8 C NA 0 B protein toxin b TOXIN 04/25/19 Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH 7F CLOSTRIDIOIDES DIFFICILE; CAMELIDAE camelidae clostridioides difficile Chen, P., Lam, K., Jin, R. 2.2 X-RAY DIFFRACTION 0.220 0.197 False True IGHV1 None None None None None 7rmh N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/MEMBRANE PROTEIN 07/27/21 Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Harris, J.A., Faust, B., Gondin, A.B., Daemgen, M.A., Suomivuori, C.M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D., Manglik, A. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5o8f K NA 0 A protein NA gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 06/13/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.2 X-RAY DIFFRACTION 0.242 0.232 False True IGHV1 NA NA None None None None None 6ewb E F 0 A protein vp1 VIRAL PROTEIN 11/03/17 Crystal structure of GII.4 UNSW 2012 P domain in complex with Fab 10E9 NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; MUS MUSCULUS mus musculus mus musculus norovirus hu/gii.4/sydney/nsw0514/2012/au Koromyslova, A.D., Hansman, G.S. 2.78 X-RAY DIFFRACTION 0.222 0.186 False True IGHV1 IGKV4 Kappa None None None None None 6z3k E F 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 6e9k A B 0 IMMUNE SYSTEM 08/01/18 The crystal structure of bovine ultralong antibody BOV-5 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 2.193 X-RAY DIFFRACTION 0.264 0.204 False True IGHV1 IGLV1 Lambda None None None None None 7mfu F NA 0 D protein NA spike protein s1 VIRAL PROTEIN 04/11/21 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 1.7 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 NA NA None None None None None 7phq F NA 0 NA NA NA NA MEMBRANE PROTEIN 08/18/21 Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM SYNTHETIC CONSTRUCT; STAPHYLOCOCCUS CAPITIS; LAMA GLAMA lama glama Bloch, J.S., Mukherjee, S., Kowal, J., Kossiakoff, A.A., Locher, K.P. 8.45 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4ffw H L 0 A protein dipeptidyl peptidase 4 HYDROLASE/Immune System, INHIBITOR 06/01/12 Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus Wang, Z., Sudom, A., Walker, N.P., Min, X. 2.9 X-RAY DIFFRACTION 0.311 0.287 False False IGHV1 IGKV4 Kappa None None None None None 5e0q A NA 0 B protein nuclear pore complex protein nup98-nup96 TRANSPORT PROTEIN 09/29/15 Crystal structure of the Nup98 C-terminal domain bound to nanobody TP377 VICUGNA PACOS; XENOPUS TROPICALIS vicugna pacos xenopus tropicalis Pleiner, T., Trakhanov, S., Goerlich, D. 1.9 X-RAY DIFFRACTION 0.196 0.167 False True IGHV1 None None None None None 7my2 H NA 0 E protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/20/21 CryoEM structure of neutralizing nanobody Nb30 in complex with SARS-CoV2 spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Xu, K., Kwong, P.D. 2.65 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 2dd8 H L 0 S protein spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 01/24/06 Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody HOMO SAPIENS; SARS CORONAVIRUS homo sapiens homo sapiens sars coronavirus Prabakaran, P., Gan, J.H., Feng, Y., Zhu, Z.Y., Xiao, X.D., Ji, X., Dimitrov, D.S. 2.3 X-RAY DIFFRACTION 0.261 0.199 False True IGHV1 IGLV3 Lambda 2.00e-08 -10.5 SPR 25 16597622 3qcv H L 0 H Hapten 18L (2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL (9Z,12Z)-OCTADECA-9,12-DIENOATE IMMUNE SYSTEM 01/17/11 Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (18:2) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fleming, J.K., Wojciak, J.M., Campbell, M.-A., Huxford, T. 2.51 X-RAY DIFFRACTION 0.266 0.215 False True IGHV5 IGKV2D Kappa None None None None None 6emj H L 0 IMMUNE SYSTEM 10/02/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 2.3 X-RAY DIFFRACTION 0.211 0.165 False True IGHV4 IGKV1 Kappa None None None None None 6vbq H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM/Viral Protein 12/19/19 Crystal structure of anti-HIV-1 antibody DH822 bound to gp120 V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Janus, B.M., Ofek, G. 2.116 X-RAY DIFFRACTION 0.211 0.181 False True IGHV1 IGLV3 Lambda None None None None None 7mep M J 0 C | F protein | protein NA | NA bg505 sosipv5.2(7s) - gp120 | bg505 sosipv5.2(7s) - gp120 VIRAL PROTEIN 04/07/21 BG505 SOSIP.v5.2(7S) in complex with the monoclonal antibodies Rh.33172 mAb.1 and RM19R MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS macaca mulatta macaca mulatta human immunodeficiency virus | human immunodeficiency virus Antanasijevic, A., Ward, A.B. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 3oay M K 0 M Hapten BDF BETA-D-FRUCTOPYRANOSE IMMUNE SYSTEM 08/05/10 A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity HOMO SAPIENS homo sapiens homo sapiens homo sapiens Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G 1.95 X-RAY DIFFRACTION 0.223 0.182 False True IGHV3 IGKV1 Kappa None None None None None 7cwu O S 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/31/20 SARS-CoV-2 spike proteins trimer in complex with P17 and FC05 Fabs cocktail HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6ymq B b 0 I protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 04/09/20 TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Scacioc, A., Mukhopadhyay, S.M.M., McKinley, G., Graslund, S., Wigren, E., Persson, H., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Di Daniel, E., Davis, J.B., Burgess-Brown, N., Bullock, A. 3.07 X-RAY DIFFRACTION 0.288 0.274 True True unknown unknown unknown None None None None None 7c2l H L 0 A protein NA spike glycoprotein MEMBRANE PROTEIN/IMMUNE SYSTEM 05/08/20 S protein of SARS-CoV-2 in complex bound with 4A8 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Guo, Y.Y., Li, Y.N., Xia, L., Zhou, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV2 Kappa None None None None None 5u65 A NA 0 IMMUNE SYSTEM 12/07/16 Camel Nanobody VHH-5 CAMELUS DROMEDARIUS camelus dromedarius Stanfield, R.L., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.261 0.201 False True IGHV1 None None None None None 6meh H L 0 C protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HEPACIVIRUS C; HOMO SAPIENS homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 1.99 X-RAY DIFFRACTION 0.230 0.186 False True IGHV1 IGKV1 Kappa None None None None None 7a6o B NA 0 A protein NA unknown BLOOD CLOTTING 08/25/20 Crystal Structure of the Complex of the Recombinant Von Willebrand Factor AIM-A1 domain and VHH81 at 2.1 Angstrom resolution HOMO SAPIENS; LAMA GLAMA Brown, A.K., Emsley, J. 2.1 X-RAY DIFFRACTION 0.256 0.195 False False IGHV3 NA NA None None None None None 5m2i K NA 0 D protein tumor necrosis factor CYTOKINE 10/13/16 Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.15 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 5.400000000000001e-10 -12.643277036143104 SPR TBD 7ec5 E F 0 B | A | C protein | protein | protein NA | NA | NA genome polyprotein | capsid protein vp1 | capsid protein vp3 VIRUS 03/11/21 EV-D68 in complex with 8F12 Fab MUS MUSCULUS; HUMAN ENTEROVIRUS D68 mus musculus mus musculus human enterovirus d68 | human enterovirus d68 | human enterovirus d68 Xu, C., Cong, Y. 2.89 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 6o1f H L 0 A | I protein | protein NA | NA tryptase alpha/beta-1 | trypsin inhibitor a IMMUNE SYSTEM/HYDROLASE 02/19/19 Complex between soybean trypsin inhibitor beta1-tryptase and a humanized fab HOMO SAPIENS; GLYCINE MAX homo sapiens homo sapiens homo sapiens | glycine max Ultsch, M.H., Yi, T. 2.15 X-RAY DIFFRACTION 0.233 0.190 False True IGHV3 IGKV1 Kappa None None None None None 5vr9 H L 0 IMMUNE SYSTEM 05/10/17 CH1/Ckappa Fab based on Matuzumab HOMO SAPIENS homo sapiens homo sapiens Hendle, J. 2.15 X-RAY DIFFRACTION 0.244 0.210 False True IGHV1 IGKV1 Kappa None None None None None 6eyo I M 0 B protein immunoglobulin heavy constant epsilon IMMUNE SYSTEM 11/13/17 Structure of extended IgE-Fc in complex with two anti-IgE Fabs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chen, J.B., Ramadani, F., Pang, M.O.Y., Beavil, R.L., Holdom, M.D., Mitropoulou, A.N., Beavil, A.J., Gould, H.J., Chang, T.W., Sutton, B.J., McDonnell, J.M., Davies, A.M. 3.7 X-RAY DIFFRACTION 0.288 0.247 False True IGHV1 IGKV3 Kappa 2e-11 -14.596006591193015 SPR TBD 7n4j H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2173. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 2.207 X-RAY DIFFRACTION 0.207 0.172 False True IGHV4 IGLV1 Lambda None None None None None 6vmk S R 0 T protein NA fab y49r light chain HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 2ajs H L 0 IMMUNE SYSTEM 08/02/05 Crystal structure of cocaine catalytic antibody 7A1 Fab' in complex with heptaethylene glycol MUS MUSCULUS mus musculus mus musculus Zhu, X., Wilson, I.A. 1.7 X-RAY DIFFRACTION 0.233 0.209 False False IGHV3 IGKV2 Kappa None None None None None 7k7r B A 0 C peptide NA ebna1 peptide aa386-405 IMMUNE SYSTEM 09/23/20 EBNA1 peptide AA386-405 with Fab MS39p2w174 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human gammaherpesvirus 4 Lanz, T.V., Robinson, W.H., Jude, K.M. 2.5 X-RAY DIFFRACTION 0.252 0.211 False True IGHV3 IGKV2 Kappa None None None None None 6nf5 E F 0 C protein hiv-1 env bg505 md64 n332-gt5 sosip gp120 VIRAL PROTEIN/immune system 12/18/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Steichen, J.M., Schief, W.R., Ward, A.B. 3.71 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 3upc G NA 0 IMMUNE SYSTEM 11/17/11 A general strategy for the generation of human antibody variable domains with increased aggregation resistance HOMO SAPIENS homo sapiens Dudgeon, K., Rouet, R., Kokmeijer, I., Langley, D.B., Christ, D. 2.8 X-RAY DIFFRACTION 0.247 0.209 False True IGHV3 None None None None None 3gkw H L 0 IMMUNE SYSTEM, ANTITUMOR PROTEIN 03/11/09 Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody HOMO SAPIENS homo sapiens homo sapiens Talavera, A., Friemann, R., Martinez-Fleites, C., Moreno, E., Krengel, U. 2.5 X-RAY DIFFRACTION 0.284 0.214 False True IGHV1 IGKV1 Kappa None None None None None 2gki A a 0 IMMUNE SYSTEM 04/02/06 Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity MUS MUSCULUS mus musculus Kim, Y.R., Kim, J.S., Lee, S.H., Lee, W.R., Sohn, J.N., Chung, Y.C., Shim, H.K., Lee, S.C., Kwon, M.H., Kim, Y.S. 2.88 X-RAY DIFFRACTION 0.242 0.212 True True unknown unknown unknown None None None None None 2gfb N M 0 IMMUNOGLOBULIN 07/07/94 CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY MUS MUSCULUS mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.0 X-RAY DIFFRACTION unknown 0.213 False False IGHV5 IGKV9 Kappa None None None None None 6zh9 F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 06/21/20 Ternary complex CR3022 H11-H4 and RBD (SARS-CoV-2) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H., Le Bas, A. 3.31 X-RAY DIFFRACTION 0.305 0.261 False False IGHV1 NA NA None None None None None 4oaw B A 0 IMMUNE SYSTEM 01/06/14 Fab structure of anti-HIV gp120 V2 mAb 2158 HOMO SAPIENS homo sapiens homo sapiens Spurrier, B.R., Kong, X.P. 2.8 X-RAY DIFFRACTION 0.254 0.182 False True IGHV1 IGKV1 Kappa None None None None None 5tgb A B 0 IMMUNE SYSTEM 09/27/16 Structure of chimeric 02-CB Fab, a VRC01-like germline antibody HOMO SAPIENS homo sapiens homo sapiens Pancera, M. 2.741 X-RAY DIFFRACTION 0.286 0.249 False True IGHV1 IGKV3 Kappa None None None None None 7rd9 H L 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM 07/09/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.159 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 1.91 X-RAY DIFFRACTION 0.233 0.186 False True IGHV1 IGKV4 Kappa None None None None None 7zwi E F 0 D protein NA gametocyte surface protein p45/48 CELL ADHESION 05/19/22 Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 Mus musculus; Plasmodium falciparum mus musculus mus musculus plasmodium falciparum Ko, K.T., Lennartz, F.L., Higgins, M.K. 1.9 X-RAY DIFFRACTION 0.217 0.189 False True IGHV5 IGKV4 Kappa None None None None None 6n5e H I 0 C protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/21/18 Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope INFLUENZA A VIRUS; MUS MUSCULUS influenza a virus mus musculus influenza a virus Bajic, G., Schmidt, A.G. 3.0 X-RAY DIFFRACTION 0.287 0.250 False True IGHV5 IGLV1 Lambda None None None None None 7beh H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.3 X-RAY DIFFRACTION 0.230 0.213 False True IGHV1 IGLV2 Lambda None None None None None 3ncy Q W 0 C | D protein | protein NA | NA adic | adic TRANSPORT PROTEIN 06/06/10 X-ray crystal structure of an arginine agmatine antiporter (AdiC) in complex with a Fab fragment SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; MUS MUSCULUS mus musculus mus musculus salmonella enterica subsp. enterica serovartyphimurium | salmonella enterica subsp. enterica serovartyphimurium Fang, Y., Jayaram, H., Shane, T., Komalkova-Partensky, L., Wu, F., Williams, C., Xiong, Y., Miller, C. 3.2 X-RAY DIFFRACTION 0.312 0.282 False True IGHV1 IGKV4 Kappa None None None None None 5k9q J K 0 F | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.503 X-RAY DIFFRACTION 0.218 0.182 False True IGHV1 IGKV1 Kappa None None None None None 2f5a H L 0 IMMUNOGLOBULIN 04/08/99 CRYSTAL STRUCTURE OF FAB' FROM THE HIV-1 NEUTRALIZING ANTIBODY 2F5 HOMO SAPIENS homo sapiens homo sapiens Bryson, S., Julien, J.P., Hynes, R.C., Pai, E.F. 2.05 X-RAY DIFFRACTION 0.270 0.235 False False IGHV2 IGKV1 Kappa None None None None None 6xli C D 0 F peptide NA tau phosphopeptide (ac-sr(pt)pslp(pt)pptre-oh) IMMUNE SYSTEM 06/28/20 CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Malia, T.J., Teplyakov, A., Luo, J. 2.0 X-RAY DIFFRACTION 0.213 0.186 False True IGHV5 IGKV14 Kappa None None None None None 4npy H L 0 IMMUNE SYSTEM 11/22/13 Crystal structure of germline Fab PGT121, a putative precursor of the broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Diwanji, D.C., Wilson, I.A. 1.796 X-RAY DIFFRACTION 0.220 0.182 False True IGHV4 IGLV3 Lambda None None None None None 6mpg m n 0 V protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False False unknown unknown unknown None None None None None 2kh2 B b 73 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5vkh A B 0 C protein ph-gated potassium channel kcsa IMMUNE SYSTEM/TRANSPORT PROTEIN 04/21/17 Closed conformation of KcsA Y82A-F103A mutant STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Cuello, L.G., Perozo, E., Cortes, D.M. 2.25 X-RAY DIFFRACTION 0.203 0.174 False False IGHV1 IGKV5 Kappa None None None None None 4y5y A B 0 C protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 330 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 2.85 X-RAY DIFFRACTION 0.241 0.221 False True IGHV3 IGLV2 Lambda None None None None None 7lbg H G 0 A protein NA envelope glycoprotein h VIRAL PROTEIN/Immune System 01/07/21 CryoEM structure of the HCMV Trimer gHgLgO in complex with human Transforming growth factor beta receptor type 3 and neutralizing fabs 13H11 and MSL-109 HUMAN CYTOMEGALOVIRUS (STRAIN MERLIN); HUMAN CYTOMEGALOVIRUS; HOMO SAPIENS homo sapiens homo sapiens human cytomegalovirus (strain merlin) Kschonsak, M., Rouge, L., Arthur, C.P., Hoangdung, H., Patel, N., Kim, I., Johnson, M., Kraft, E., Rohou, A.L., Gill, A., Martinez-Martin, N., Payandeh, J., Ciferri, C. 2.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 4n1e NA D 0 J protein lysozyme c Immune system/Hydrolase 10/04/13 Structural evidence for antigen receptor evolution HOMO SAPIENS; GALLUS GALLUS homo sapiens gallus gallus Langley, D.B., Rouet, R., Stock, D., Christ, D. 2.23 X-RAY DIFFRACTION 0.265 0.223 False True IGKV1 Kappa None None None None None 3o6k H L 0 IMMUNE SYSTEM 07/29/10 Crystal structure of anti-Tat HIV Fab'11H6H1 MUS MUSCULUS mus musculus mus musculus Serriere, J., Gouet, P., Guillon, C. 2.0 X-RAY DIFFRACTION 0.246 0.199 False False IGHV5 IGKV1 Kappa None None None None None 7p79 B NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 07/19/21 SARS-CoV-2 spike protein in complex with sybodyb#15 in a 1up/1up-out/1down conformation. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Walter, J.D., Hutter, C.A.J., Garaeva, A.A., Scherer, M., Zimmermann, I., Wyss, M., Rheinberger, J., Ruedin, Y., Earp, J.C., Egloff, P., Sorgenfrei, M., Huerlimann, L.M., Gonda, I., Meier, G., Remm, S., Thavarasah, S., Zimmer, G., Slotboom, D.J., Paulino, C., Plattet, P., Seeger, M.A. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3j8z H L 0 E protein NA l1 VIRUS/IMMUNE SYSTEM 11/20/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 14 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 7lqv W X 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/15/21 Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gorman, J., Rapp, M., Kwong, P.D., Shapiro, L. 3.25 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 6ii8 G I 0 A protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L4B-18 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.32 X-RAY DIFFRACTION 0.251 0.203 False True IGHV3 IGLV6 Lambda 3.8600000000000004e-07 -8.749460362550247 SPR TBD 6nm6 H L 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 01/10/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to N6 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.2 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.739 X-RAY DIFFRACTION 0.288 0.240 False True IGHV4 unknown unknown None None None None None 5mwn F NA 0 C protein type vi secretion protein TRANSPORT PROTEIN 01/18/17 Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 LAMA GLAMA; ESCHERICHIA COLI lama glama escherichia coli Cambillau, C., Nguyen, V.S., Spinelli, S., Legrand, P. 2.2 X-RAY DIFFRACTION 0.220 0.199 False True IGHV1 None None None None None 6nfc H L 0 A protein NA hiv-1 env bg505 md64 n332-gt5 sosip gp120 VIRAL PROTEIN 12/19/18 BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.43 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 5uty H L 0 G protein hiv-1 bg505 strain env gp120 VIRAL PROTEIN/immune system 02/15/17 Crystal Structure of a Stabilized DS-SOSIP.mut4 BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, N300M, N302M, T320L in Complex with Human Antibodies PGT122 and 35O22 at 4.1 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Chuang, G.-Y., Pancera, M., Kwong, P.D. 3.412 X-RAY DIFFRACTION 0.288 0.241 False True IGHV4 IGLV3 Lambda None None None None None 7bub H L 0 A | C protein | protein NA | NA dengue virus serotype2 e protein | dengue virus serotype2 e protein VIRUS 04/06/20 Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 6.5 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 | dengue virus 2 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5hvg D NA 0 C protein carboxypeptidase b2 hydrolase/hydrolase inhibitor 01/28/16 Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204) VICUGNA PACOS; HOMO SAPIENS vicugna pacos homo sapiens Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 3.05 X-RAY DIFFRACTION 0.212 0.179 False True IGHV1 6.3e-10 -12.551945274084549 SPR TBD 6cdm D E 0 F peptide hiv fusion peptide (512-519) IMMUNE SYSTEM 02/08/18 Structure of vaccine-elicited HIV-1 neutralizing antibody vFP7.04 in complex with HIV-1 fusion peptide residue 512-519 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.408 X-RAY DIFFRACTION 0.222 0.184 False True IGHV1 IGKV1 Kappa 8.050000000000001e-10 -12.406714218098521 Unknown TBD 3wfe H L 0 B | C protein | protein NA | NA nitric oxide reductase subunit b | nitric oxide reductase subunit c IMMUNE SYSTEM/OXIDOREDUCTASE 07/18/13 Reduced and cyanide-bound cytochrome c-dependent nitric oxide reductase (cNOR) from Pseudomonas aeruginosa in complex with antibody fragment PSEUDOMONAS AERUGINOSA; MUS MUSCULUS mus musculus mus musculus pseudomonas aeruginosa | pseudomonas aeruginosa Sato, N., Ishii, S., Hino, T., Sugimoto, H., Fukumori, Y., Shiro, Y., Tosha, T. 2.49 X-RAY DIFFRACTION 0.227 0.189 False False IGHV1 IGKV16 Kappa None None None None None 1bww NA B 0 IMMUNE SYSTEM 09/29/98 BENCE-JONES IMMUNOGLOBULIN REI VARIABLE PORTION, T39K MUTANT HOMO SAPIENS homo sapiens Uson, I., Pohl, E., Schneider, T.R., Dauter, Z., Schmidt, A., Fritz, H.J., Sheldrick, G.M. 1.7 X-RAY DIFFRACTION unknown unknown False True IGKV1 Kappa None None None None None 6rp8 H L 0 C protein NA cytotoxic t-lymphocyte protein 4 IMMUNE SYSTEM 05/14/19 Crystal Structure of Ipilimumab Fab complexed with CTLA-4 at 2.6A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhang, F., Zhou, A. 2.6 X-RAY DIFFRACTION 0.267 0.211 False True IGHV3 IGKV3 Kappa None None None None None 5v6l H L 0 P peptide envelope glycoprotein, v3 region VIRAL PROTEIN/IMMUNE SYSTEM 03/17/17 Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A37 in complex with V3 peptide JR-FL ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Pan, R., Kong, X.-P. 2.549 X-RAY DIFFRACTION 0.252 0.206 False True IGHV1 IGKV1 Kappa None None None None None 7ps6 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-44 and Beta-54 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.26 X-RAY DIFFRACTION 0.240 0.215 False True IGHV4 IGKV1 Kappa None None None None None 2r4s H L 0 A protein beta-2 adrenergic receptor SIGNALING PROTEIN 08/31/07 Crystal structure of the human beta2 adrenoceptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K. 3.4 X-RAY DIFFRACTION 0.280 0.226 False False IGHV1 IGKV14 Kappa None None None None None 5w6g H L 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/16/17 Human antibody 6649 in complex with influenza hemagglutinin H1 Solomon Islands INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Raymond, D.D., Harrison, S.C. 2.79 X-RAY DIFFRACTION 0.253 0.218 False True IGHV4 IGLV1 Lambda 2.12e-06 -7.740262767026869 BLI TBD 3rvu D C 0 IMMUNE SYSTEM 05/06/11 Structure of 4C1 Fab in C2221 space group MUS MUSCULUS mus musculus mus musculus Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W. 2.5 X-RAY DIFFRACTION 0.267 0.211 False True IGHV3 IGKV14 Kappa None None None None None 3ru8 H L 0 X protein epitope scaffold 2bodx43 DE NOVO PROTEIN, IMMUNE SYSTEM 05/04/11 Structure of an HIV epitope scaffold in complex with neutralizing antibody b12 Fab HUMAN IMMUNODEFICIENCY VIRUS, SYNTHETIC CONSTRUCT, THERMOMONOSPORA FUSCA; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus, syntheticconstruct, thermomonospora fusca Carrico, C.T.D., Strong, R.K. 2.07 X-RAY DIFFRACTION 0.203 0.168 False True IGHV1 IGKV3 Kappa 3.35e-08 -10.19 SPR 25 22021856 5mhs E D 0 B | A protein | protein NA | NA outer capsid protein sigma-1 | outer capsid protein sigma-1 IMMUNE SYSTEM 11/25/16 T1L reovirus sigma1 complexed with 5C6 Fab fragments REOVIRUS TYPE 1 (STRAIN LANG); MUS MUSCULUS mus musculus mus musculus reovirus type 1 (strain lang) | reovirus type 1 (strain lang) Stehle, T., Dietrich, M.H. 3.7 X-RAY DIFFRACTION 0.278 0.261 False False IGHV2 IGKV3 Kappa None None None None None 2ap2 B A 0 P peptide protein (p-glycoprotein) IMMUNE SYSTEM 03/22/99 SINGLE CHAIN FV OF C219 IN COMPLEX WITH SYNTHETIC EPITOPE PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Van Den Elsen, J.M.H., Rose, D.R. 2.4 X-RAY DIFFRACTION 0.274 0.221 True True IGHV14 IGKV8 Kappa None None None None None 6u0n I J 0 B protein envelope glycoprotein gp120 VIRAL PROTEIN 08/14/19 Asymmetrically open conformational state (Class II) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Yang, Z., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 2v7n H G 0 IMMUNE SYSTEM 07/31/07 Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4 SYNTHETIC CONSTRUCT synthetic construct synthetic construct Frey, D., Huber, T., Plueckthun, A., Gruetter, M.G. 1.92 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 1keg H L 0 A nucleic-acid 5'-d(*tp*(64t)p*tp*t)-3' IMMUNE SYSTEM/DNA 11/15/01 Antibody 64M-2 Fab complexed with dTT(6-4)TT MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Yokoyama, H., Mizutani, R., Satow, Y., Sato, K., Komatsu, Y., Ohtsuka, E., Nikaido, O. 2.4 X-RAY DIFFRACTION 0.268 0.201 False False IGHV1 IGKV1 Kappa None None None None None 4p3d H L 0 M peptide matrix metalloproteinase-14 IMMUNE SYSTEM 03/07/14 MT1-MMP:Fab complex (Form II) MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Rozenberg, H., Udi, Y., Sagi, I. 1.949 X-RAY DIFFRACTION 0.210 0.158 False True IGHV5 IGKV1 Kappa None None None None None 6qx4 C NA 0 A protein s-layer protein sap STRUCTURAL PROTEIN 03/07/19 Structure of the Bacillus anthracis Sap S-layer assembly domain BACILLUS ANTHRACIS; LAMA GLAMA lama glama bacillus anthracis Remaut, H., Fioravanti, A. 3.27 X-RAY DIFFRACTION 0.218 0.173 False True IGHV1 None None None None None 6jc2 H L 0 IMMUNE SYSTEM 01/27/19 Crystal structure of the Fab fragment of ipilimumab HOMO SAPIENS homo sapiens homo sapiens Heo, Y.S. 2.65 X-RAY DIFFRACTION 0.263 0.202 False True IGHV3 IGKV3 Kappa None None None None None 7k5y N n 0 G | H protein | protein NA | NA histone h2a type 1-b/e | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of a chromatosome containing human linker histone H1.4 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 2.76 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5kvg H L 0 E protein zika envelope diii VIRAL PROTEIN/IMMUNE SYSTEM 07/14/16 Zika specific antibody, ZV-67, bound to ZIKA envelope DIII ZIKA VIRUS; MUS MUSCULUS mus musculus mus musculus zika virus Zhao, H., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 1.4 X-RAY DIFFRACTION 0.179 0.148 False False IGHV1 IGKV6 Kappa 8.800000000000001e-09 -10.989691901661018 SPR TBD 5vm4 L NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 5uk4 p NA 0 P protein anti-vesicular stomatitis virus n vhh Viral Protein/RNA/Immune System 01/19/17 VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 VESICULAR STOMATITIS INDIANA VIRUS (STRAIN SAN JUAN); VICUGNA PACOS vicugna pacos vesicular stomatitis indiana virus (strain sanjuan) Hanke, L., Knockenhauer, K.E., Ploegh, H.L., Schwartz, T.U. 3.204 X-RAY DIFFRACTION 0.288 0.237 False False IGHV1 None None None None None 6e3y N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 07/16/18 Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor LAMA GLAMA; HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Liang, Y.L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T.S., Radjainia, M., Plitzko, J.M., Baumeister, W., Miller, L.J., Hay, D.L., Christopoulos, A., Reynolds, C.A., Wootten, D., Sexton, P.M. 3.3 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6ewb H L 0 B protein vp1 VIRAL PROTEIN 11/03/17 Crystal structure of GII.4 UNSW 2012 P domain in complex with Fab 10E9 NOROVIRUS HU/GII.4/SYDNEY/NSW0514/2012/AU; MUS MUSCULUS mus musculus mus musculus norovirus hu/gii.4/sydney/nsw0514/2012/au Koromyslova, A.D., Hansman, G.S. 2.78 X-RAY DIFFRACTION 0.222 0.186 False True IGHV1 IGKV4 Kappa None None None None None 3wkm I M 0 B protein putative zinc metalloprotease aq_1964 HYDROLASE 10/28/13 The periplasmic PDZ tandem fragment of the RseP homologue from Aquifex aeolicus in complex with the Fab fragment AQUIFEX AEOLICUS; MUS MUSCULUS mus musculus mus musculus aquifex aeolicus Nogi, T., Tabata, S., Tamura-kawakami, K., Takagi, J. 2.2 X-RAY DIFFRACTION 0.272 0.224 False False IGHV14 IGKV3 Kappa None None None None None 7mjs H L 0 X protein NA major facilitator superfamily domain containing 2a LIPID TRANSPORT/IMMUNE SYSTEM 04/20/21 Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3 SYNTHETIC CONSTRUCT; GALLUS GALLUS synthetic construct synthetic construct gallus gallus Cater, R.J., Chua, G.L., Erramilli, S.K., Keener, J.E., Choy, B.C., Tokarz, P., Chin, C.F., Quek, D.Q.Y., Kloss, B., Pepe, J.G., Parisi, G., Wong, B.H., Clarke, O.B., Marty, M.T., Kossiakoff, A.A., Khelashvili, G., Silver, D.L., Mancia, F. 3.03 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6tys H L 0 A protein fusion glycoprotein f0 VIRAL PROTEIN/IMMUNE SYSTEM 08/09/19 A potent cross-neutralizing antibody targeting the fusion glycoprotein inhibits Nipah virus and Hendra virus infection NIPAH VIRUS; MUS MUSCULUS mus musculus mus musculus nipah virus Dang, H.V., Chan, Y.P., Park, Y.J., Snijder, J., Da Silva, S.C., Vu, B., Yan, L., Feng, Y.R., Rockx, B., Geisbert, T., Mire, C.E., Broder, C.B., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.5 ELECTRON MICROSCOPY False True IGHV5 IGKV12 Kappa None None None None None 7o3b C NA 0 I protein NA tau-tubulin kinase 2,centrosomal protein of 164 kda STRUCTURAL PROTEIN 04/01/21 Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody CAMELIDAE MIXED LIBRARY; HOMO SAPIENS camelidae mixed library homo sapiens e Silva, I.R., van Breugel, M. 2.4 X-RAY DIFFRACTION 0.240 0.189 False True IGHV1 NA NA None None None None None 6uul C D 0 NA NA NA NA IMMUNE SYSTEM 10/30/19 Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5 HOMO SAPIENS homo sapiens homo sapiens Kumar, S., Wilson, I.A. 2.06 X-RAY DIFFRACTION 0.246 0.201 False True unknown IGKV3 Kappa None None None None None 3cfk B A 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 6bli G H 0 I peptide major surface glycoprotein g VIRAL PROTEIN/IMMUNE SYSTEM 11/10/17 RSV G peptide bound to Fab CB002.5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human respiratory syncytial virus a (strainrsb6256) Jones, H.G., McLellan, J.S., Langedijk, J.P. 2.12 X-RAY DIFFRACTION 0.218 0.169 False True IGHV4 IGKV1 Kappa 5.200000000000001e-10 -12.665637564550789 Unknown TBD 7ekb H L 0 P peptide NA mper region of the hiv-1 envelope glycoprotein proteingp41 IMMUNE SYSTEM 04/05/21 Crystal structure of 4E10 modified with pyrene acetamide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caaveiro, J.M.M., Rujas, E., Nieva, J.L. 1.45 X-RAY DIFFRACTION 0.151 0.120 False True IGHV1 IGKV3 Kappa None None None None None 6r2s B A 0 C protein duffy receptor IMMUNE SYSTEM 03/18/19 The structure of Plasmodium vivax Duffy binding protein (PvDBP) bound to human antibody DB9 HOMO SAPIENS; PLASMODIUM VIVAX (STRAIN SALVADOR I) homo sapiens homo sapiens plasmodium vivax (strain salvador i) Barber, N.M., Higgins, M.K. 3.04 X-RAY DIFFRACTION 0.238 0.202 False True IGHV4 IGKV1 Kappa None None None None None 7bek H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-158 Fab (crystal form 2) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.04 X-RAY DIFFRACTION 0.220 0.200 False True IGHV3 IGKV1 Kappa None None None None None 2qqn H L 0 A protein neuropilin-1 SIGNALING PROTEIN 07/26/07 Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Appleton, B.A., Wiesmann, C. 2.2 X-RAY DIFFRACTION 0.207 0.159 False True IGHV3 IGKV1 Kappa None None None None None 6a4k J N 0 C protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/20/18 Human antibody 32D6 Fab in complex with H1N1 influenza A virus HA1 INFLUENZA A VIRUS (A/CALIFORNIA/7/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/7/2009(h1n1)) Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 3.15 X-RAY DIFFRACTION 0.233 0.175 False True IGHV4 IGLV4 Lambda None None None None None 5w9p K L 0 H protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6flc H L 0 G protein domain iii of dengue virus 2 VIRAL PROTEIN 01/25/18 2C8 Fab bound to EDIII of DenV 2 MUS MUSCULUS; DENGUE VIRUS 2 mus musculus mus musculus dengue virus 2 Flanagan, A., Renner, M., Grimes, J.M. 2.0 X-RAY DIFFRACTION 0.216 0.180 False True IGHV7 IGKV12 Kappa 1.767e-07 -9.212417624520992 SPR TBD 7lxy M K 0 J protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2X333 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 4rzc A B 0 A carbohydrate M6P ALPHA-D-MANNOSE-6-PHOSPHATE IMMUNE SYSTEM 12/19/14 Fv M6P-1 in complex with mannose-6-phosphate ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Blackler, R.J., Evans, D.W., Evans, S.V., Muller-Loennies, S. 2.723 X-RAY DIFFRACTION 0.267 0.226 False True IGHV1 IGKV1 Kappa None None None None None 7r8n H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C051 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6ztd H L 0 NA NA NA NA IMMUNE SYSTEM 07/18/20 Crystal structure of the BCR Fab fragment from subset #169 case P6540 HOMO SAPIENS homo sapiens homo sapiens Carriles, A.A., Minici, C., Degano, M. 3.43 X-RAY DIFFRACTION 0.263 0.217 False True IGHV3 IGLV3 Lambda None None None None None 7rfc H L 0 D protein NA envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 07/14/21 Crystal structure of broadly neutralizing antibody mAb1382 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain HOMO SAPIENS; HEPACIVIRUS C homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 3.24 X-RAY DIFFRACTION 0.284 0.233 False True IGHV1 IGKV3 Kappa None None None None None 6mwc O P 0 N protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.5 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 5icx D C 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with CQFDLSTRRLRCGGSK meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.6 X-RAY DIFFRACTION 0.222 0.177 False True IGHV2 IGKV5 Kappa 1.1e-07 -9.493238899799852 Unknown TBD 7oay D NA 0 C protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 2.34 X-RAY DIFFRACTION 0.228 0.192 False False IGHV1 NA NA None None None None None 4np4 I M 0 A protein toxin b IMMUNE SYSTEM 11/20/13 Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab CLOSTRIDIUM DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens clostridium difficile Orth, P., Xiao, L., Hernandez, L.D., Reichert, P., Sheth, P., Beaumont, M., Murgolo, N., Ermakov, G., DiNunzio, E., Racine, F., Karczewski, J., Secore, S., Ingram, R.N., Mayhood, T., Strickland, C., Therien, A.G. 2.89 X-RAY DIFFRACTION 0.232 0.198 False False IGHV5 IGKV3 Kappa 1.9e-11 -14.626397031011077 SPR TBD 3fzu H L 0 IMMUNE SYSTEM 01/26/09 IgG1 Fab characterized by H/D exchange HOMO SAPIENS homo sapiens homo sapiens Arndt, J., Houde, D., Domeier, W., Berkowitz, S., Engen, J.R. 2.5 X-RAY DIFFRACTION 0.261 0.210 False True IGHV3 IGKV1 Kappa None None None None None 6iyn A NA 12 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7r8m D E 0 C protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C032 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 DeLaitsch, A.T., Barnes, C.O., Bjorkman, P.J. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV5 IGLV1 Lambda None None None None None 1nd0 F E 0 E Hapten DP4 (1S,4S)-4-[DIMETHYL(PHENYL)SILYL]-1-METHYLPIPERIDINE 1-OXIDE IMMUNE SYSTEM 12/05/02 CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 2.45 X-RAY DIFFRACTION 0.286 0.242 False False IGHV3 IGKV1 Kappa None None None None None 6rai C NA 0 B protein multidrug resistance abc transporter atp-binding andpermease protein TRANSPORT PROTEIN 04/06/19 Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing occluded conformation THERMUS THERMOPHILUS; VICUGNA PACOS vicugna pacos thermus thermophilus Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R. 2.9 ELECTRON MICROSCOPY False True IGHV1 None None None None None 5nm0 B NA 0 IMMUNE SYSTEM 04/05/17 Nb36 Ser85Cys with Hg, crystal form 1 LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 1.5 X-RAY DIFFRACTION 0.211 0.189 False True IGHV1 None None None None None 7tzf N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 02/15/22 Human Amylin3 Receptor in complex with Gs and rat amylin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens | homo sapiens Cao, J., Belousoff, M.J., Johnson, R.M., Wootten, D.L., Sexton, P.M. 2.4 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6s3d A B 0 N protein s0_2.126 ANTIVIRAL PROTEIN 06/25/19 Structure of D25 Fab in complex with scaffold S0_2.126 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Cramer, J.T., Krey, T. 3.0 X-RAY DIFFRACTION 0.292 0.269 False True IGHV1 IGKV1 Kappa None None None None None 6ba5 H G 0 P protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/12/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.62 X-RAY DIFFRACTION 0.214 0.194 False True IGHV1 IGKV1 Kappa None None None None None 7a0x C D 0 A protein NA na(+)/h(+) antiporter nhaa MEMBRANE PROTEIN 08/11/20 Structure of dimeric sodium proton antiporter NhaA, at pH 6.0, crystallized with chimeric Fab antibodies SALMONELLA TYPHIMURIUM (STRAIN LT2 / SGSC1412 / ATCC 700720); GALLUS GALLUS; HOMO SAPIENS gallus gallus, homo sapiens gallus gallus, homo sapiens salmonella typhimurium (strain lt2 / sgsc1412 /atcc 700720) Fippel, A., Lentes, C.J., Mir, S.H., Wirth, C., Hunte, C. 2.37 X-RAY DIFFRACTION 0.241 0.205 False True unknown unknown unknown None None None None None 7soc H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S RBD B.1.617.1 kappa variant S309 Local Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6wfx H L 0 P peptide NA npna2 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab395 in complex with NPNA2 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 2.59 X-RAY DIFFRACTION 0.244 0.198 False True IGHV3 IGKV1 Kappa None None None None None 7zml G NA 0 D protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G1-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.79 X-RAY DIFFRACTION 0.260 0.223 False True IGHV1 NA NA None None None None None 5viy K L 0 B protein NA envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 04/17/17 BG505 SOSIP.664 in complex with broadly neutralizing antibodies BG1 and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 6.2 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 2qr0 X W 0 V protein vascular endothelial growth factor a IMMUNE SYSTEM 07/27/07 Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wiesmann, C. 3.5 X-RAY DIFFRACTION 0.312 0.291 False False IGHV3 IGKV1 Kappa 7.80e-09 -11.5 SPR 37 17825836 7qnd K NA 0 B protein NA gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 12/20/21 Cryo-EM structure of human full-length extrasynaptic beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sente, A., Desai, R., Naydenova, K., Malinauskas, T., Jounaidi, Y., Miehling, J., Zhou, X., Masiulis, S., Hardwick, S.W., Chirgadze, D.Y., Miller, K.W., Aricescu, A.R. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6did L H 0 A | B protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 VIRAL PROTEIN 05/23/18 HIV Env BG505 SOSIP with polyclonal Fabs from immunized rabbit #3417 post-boost#1 HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 | human immunodeficiency virus 1 Turner, H.L., Cottrell, C.A., Oyen, D., Wilson, I.A., Ward, A.B. 4.71 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 1ub5 A B 0 B Hapten SPB 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID IMMUNE SYSTEM 03/30/03 Crystal structure of Antibody 19G2 with hapten at 100K MUS MUSCULUS mus musculus mus musculus mus musculus Beuscher, A.B., Wirsching, P., Lerner, R.A., Janda, K., Stevens, R.C. 2.0 X-RAY DIFFRACTION 0.267 0.248 False True IGHV5 IGKV2 Kappa None None None None None 3l7f B A 0 IMMUNE SYSTEM 12/28/09 Structure of IL-13 antibody H2L6, A humanized variant OF C836 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.6 X-RAY DIFFRACTION 0.243 0.205 False True IGHV2 IGKV3 Kappa None None None None None 5vph D C 0 A protein peptidase 1 HYDROLASE/IMMUNE SYSTEM 05/05/17 CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1 MUS MUSCULUS; DERMATOPHAGOIDES PTERONYSSINUS mus musculus mus musculus dermatophagoides pteronyssinus Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W. 2.5 X-RAY DIFFRACTION 0.229 0.178 False True IGHV3 IGKV14 Kappa None None None None None 6mlm K L 0 H protein hemagglutinin ha1 chain VIRAL PROTEIN/Immune System 09/27/18 H7 HA0 in complex with Fv from H7.5 IgG INFLUENZA A VIRUS (A/NEW YORK/107/2003(H7N2)); INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/new york/107/2003(h7n2)) Pallesen, J., Turner, H.L., Ward, A.B. 3.5 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 2dqe H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/25/06 Crystal structure of hyhel-10 FV mutant (Hy53a) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 1.9 X-RAY DIFFRACTION 0.224 0.194 False True IGHV3 IGKV5 Kappa None None None None None 1q1j H L 0 P peptide gp120 v3 peptide IMMUNE SYSTEM 07/21/03 Crystal Structure Analysis of anti-HIV-1 Fab 447-52D in complex with V3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Stanfield, R.L., Gorny, M.K., Williams, C., Zolla-Pazner, S., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.285 0.250 False False IGHV3 IGLV1 Lambda None None None None None 5njd P O 0 I | B protein | protein NA | NA interleukin-12 subunit beta | interleukin-23 subunit alpha IMMUNE SYSTEM 03/28/17 Structure of Interleukin 23 in complex with Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Bloch, Y., Savvides, S.N. 3.9 X-RAY DIFFRACTION 0.312 0.272 False True IGHV3 IGLV1 Lambda None None None None None 5icz B A 0 IMMUNE SYSTEM 02/23/16 Cetuximab Fab in complex with GQFDLSTRRLKG peptide MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.55 X-RAY DIFFRACTION 0.221 0.171 False True IGHV2 IGKV5 Kappa 5e-06 -7.231898839371053 Unknown TBD 5ff6 B A 0 IMMUNE SYSTEM 12/17/15 Cetuximab Fab in complex with L10Q meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.5 X-RAY DIFFRACTION 0.201 0.155 False True IGHV2 IGKV5 Kappa 9.499999999999999e-06 -6.851610886869331 Unknown TBD 7k3a H G 0 A | B protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation B, fusion peptide release INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 3wfc H L 0 B | C protein | protein NA | NA nitric oxide reductase subunit b | nitric oxide reductase subunit c IMMUNE SYSTEM/OXIDOREDUCTASE 07/18/13 Reduced and carbonmonoxide-bound cytochrome c-dependent nitric oxide reductase (cNOR) from Pseudomonas aeruginosa in complex with antibody fragment MUS MUSCULUS; PSEUDOMONAS AERUGINOSA mus musculus mus musculus pseudomonas aeruginosa | pseudomonas aeruginosa Sato, N., Ishii, S., Hino, T., Sugimoto, H., Fukumori, Y., Shiro, Y., Tosha, T. 2.5 X-RAY DIFFRACTION 0.232 0.191 False False IGHV1 IGKV16 Kappa None None None None None 4nyl C D 0 IMMUNE SYSTEM 12/10/13 Crystal structure of adalimumab FAB fragment HOMO SAPIENS homo sapiens homo sapiens Fan, L.J., Lv, L.L., Zhang, Q.J., Chen, C.L. 2.8 X-RAY DIFFRACTION 0.358 0.275 False True IGHV3 IGKV1 Kappa None None None None None 4xbg A B 0 A Hapten 44E (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate IMMUNE SYSTEM 12/16/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA): 2.73 A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.73 X-RAY DIFFRACTION 0.246 0.202 False True IGHV1 IGKV3 Kappa None None None None None 6dbg D NA 0 IMMUNE SYSTEM 05/03/18 Crystal Structure of VHH R303 in complex with InlB-LRR-IR LISTERIA MONOCYTOGENES; CAMELUS DROMEDARIUS camelus dromedarius Brooks, C.L., Toride King, M., Huh, I. 1.51 X-RAY DIFFRACTION 0.180 0.160 False True IGHV1 None None None None None 1mak NA A 11 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7rdj B A 0 NA NA NA NA IMMUNE SYSTEM 07/09/21 Crystal structure of PCDN-16B, an anti-HIV antibody from the PCDN bnAb lineage (non-cysteinylated state) HOMO SAPIENS homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 1.93 X-RAY DIFFRACTION 0.210 0.170 False True IGHV4 IGKV3 Kappa None None None None None 4evn C D 0 immune system 04/26/12 Crystal Structure of Fab CR6261 (somatic heavy chain with germline-reverted light chain) HOMO SAPIENS homo sapiens homo sapiens Whittle, J.R.R. 2.851 X-RAY DIFFRACTION 0.293 0.230 False True IGHV1 IGLV1 Lambda None None None None None 1ggc H L 0 IMMUNOGLOBULIN 07/19/93 MAJOR ANTIGEN-INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY MUS MUSCULUS mus musculus mus musculus Takimoto-Kamimura, M., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.190 False True IGHV8 IGKV3 Kappa None None None None None 4xrc H L 0 C protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 01/20/15 Antibody hemagglutinin Complexes HOMO SAPIENS; INFLUENZA A VIRUS (A/CHICKEN/THAILAND/TAK-01/2004(H5N1)) homo sapiens homo sapiens influenza a virus (a/chicken/thailand/tak-01/2004(h5n1)) Spiller, B.W., Winarski, K.L. 2.74 X-RAY DIFFRACTION 0.248 0.192 False True IGHV4 IGLV3 Lambda None None None None None 4mqs B NA 0 A protein NA muscarinic acetylcholine receptor m2 SIGNALING PROTEIN 09/16/13 Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K. 3.5 X-RAY DIFFRACTION 0.298 0.249 False True IGHV1 NA NA None None None None None 7jvb C NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 08/20/20 Crystal structure of the SARS-CoV-2 spike receptor-binding domain (RBD) with nanobody Nb20 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Xiang, Y., Xiao, Z., Liu, H., Sang, Z., Schneidman-Duhovny, D., Zhang, C., Shi, Y. 3.287 X-RAY DIFFRACTION 0.322 0.281 False True IGHV1 NA NA None None None None None 1x9q a A 0 IMMUNE SYSTEM 08/24/04 4m5.3 anti-fluorescein single chain antibody fragment (scFv) HOMO SAPIENS homo sapiens Midelfort, K.S., Hernandez, H.H., Lippow, S.M., Tidor, B., Drennan, C.L., Wittrop, K.D. 1.5 X-RAY DIFFRACTION 0.193 0.165 True True unknown unknown unknown None None None None None 2ai0 H L 0 IMMUNE SYSTEM 07/28/05 Anti-Cocaine Antibody 7.5.21, Crystal Form III MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Ringe, D., Petsko, G.A. 2.2 X-RAY DIFFRACTION 0.279 0.222 False False IGHV5 IGKV1 Kappa None None None None None 7d6y B NA 0 A protein NA eukaryotic translation initiation factor 4e RNA BINDING PROTEIN 10/02/20 eIF4E in Complex with a Disulphide-Free Autonomous VH Domain HOMO SAPIENS homo sapiens homo sapiens Brown, C.J., Frosi, Y., Jiang, S., Lin, Y.C. 1.668 X-RAY DIFFRACTION 0.206 0.182 False True IGHV3 NA NA None None None None None 1cz8 H L 0 W protein vascular endothelial growth factor IMMUNE SYSTEM 09/01/99 VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B. 2.4 X-RAY DIFFRACTION 0.267 0.208 False True IGHV7 IGKV1 Kappa 1.10e-10 -14.12 SPR 37 10543973 6hda A NA 0 TRANSPORT PROTEIN 08/17/18 Crystal structure of the potassium channel MtTMEM175 with cesium LAMA GLAMA; ESCHERICHIA COLI (STRAIN K12); MARIVIRGA TRACTUOSA DSM 4126 lama glama, escherichia coli (strain k12) Brunner, J.D., Jakob, R.P., Schulze, T., Neldner, Y., Moroni, A., Thiel, G., Maier, T., Schenck, S. 3.8 X-RAY DIFFRACTION 0.337 0.280 False True IGHV1 None None None None None 1vhp A NA 3 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 4xcn J K 0 IMMUNE SYSTEM 12/18/14 Crystal structure of human 4E10 Fab in complex with phosphatidic acid (06:0 PA); 2.9 A resolution HOMO SAPIENS homo sapiens homo sapiens Irimia, A., Stanfield, R.L., Wilson, I.A. 2.9 X-RAY DIFFRACTION 0.246 0.193 False True IGHV1 IGKV3 Kappa None None None None None 7rm3 C D 0 P peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2E10.E9 in complex with P. vivax CSP peptide ANGAGNQPGANGAGNQPGANGAGGQAA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 2.68 X-RAY DIFFRACTION 0.239 0.207 False True IGHV9 IGKV8 Kappa None None None None None 6gv4 H L 0 B | A protein | protein NA | NA vp1 | vp0 VIRUS 06/20/18 High-resolution Cryo-EM of Fab-labeled human parechovirus 3 HOMO SAPIENS; HUMAN PARECHOVIRUS 3 homo sapiens homo sapiens human parechovirus 3 | human parechovirus 3 Domanska, A., Flatt, J.W., Jukonen, J.J.J., Geraets, J.A., Butcher, S.J. 2.8 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 5mu0 C D 0 R peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 3ria H L 0 A protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.8 X-RAY DIFFRACTION 0.280 0.266 False True IGHV1 IGLV1 Lambda None None None None None 3qxv A NA 0 A Hapten MTX METHOTREXATE IMMUNE SYSTEM 03/02/11 Structure of an Anti-Methotrexate CDR1-4 Graft VHH Antibody in Complex with Methotrexate LAMA GLAMA lama glama lama glama Fanning, S.W., Horn, J.R. 2.5 X-RAY DIFFRACTION 0.279 0.230 False True IGHV1 4e-09 -11.456840020052727 Unknown TBD 3nac H L 0 IMMUNE SYSTEM 06/01/10 Crystal structure of Fab15 Mut7 HOMO SAPIENS homo sapiens homo sapiens Luo, J. 1.8 X-RAY DIFFRACTION 0.212 0.184 False True IGHV5 IGKV1 Kappa None None None None None 7vuz S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 11/04/21 Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Yu, L., Fang, Y. 2.89 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6v8z O R 0 M protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 2.9 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6kz0 B C 0 A protein genome polyprotein VIRAL PROTEIN 05/27/20 HRV14 3C in complex with single chain antibody GGVV HUMAN RHINOVIRUS 14; HOMO SAPIENS homo sapiens homo sapiens human rhinovirus 14 Meng, B., Yang, B., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.223 0.185 False True IGHV1 IGKV1 Kappa None None None None None 6ghg A B 0 IMMUNE SYSTEM 05/07/18 Variable heavy - variable light domain and Fab-arm CrossMabs with charged residue exchanges HOMO SAPIENS homo sapiens homo sapiens Regula, J., Imhof-Jung, S., Molhoj, M., Benz, J., Ehler, A., Bujotzek, A., Schaefer, W., Klein, C. 1.88 X-RAY DIFFRACTION 0.226 0.195 False True IGHV3 IGKV3 Kappa None None None None None 4gw5 B A 0 Immune system 08/31/12 cQYN meditope - Cetuximab Fab MURINAE,HOMO SAPIENS; SYNTHETIC CONSTRUCT murinae,homo sapiens murinae,homo sapiens Donaldson, J.M., Zer, C., Avery, K.N., Bzymek, K.P., Horne, D.A., Williams, J.C. 2.2 X-RAY DIFFRACTION 0.222 0.174 False True IGHV2 IGKV5 Kappa 3.5e-06 -7.443222922719666 Unknown TBD 6oz2 H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 05/15/19 Crystal structure of the broadly neutralizing antibody N49P6 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 2.55 X-RAY DIFFRACTION 0.273 0.219 False True unknown IGLV2 Lambda None None None None None 2vl5 A B 0 IMMUNE SYSTEM 01/08/08 Structure of anti-collagen type II FAb CIIC1 MUS MUSCULUS mus musculus mus musculus Uysal, H., Sehnert, B., Nandakumar, K.S., Boiers, U., Burkhardt, H., Holmdahl, R., Thunnissen, M.M. 2.1 X-RAY DIFFRACTION 0.289 0.212 False False IGHV1 IGKV3 Kappa None None None None None 4idl A NA 0 IMMUNE SYSTEM 12/12/12 Low melting temperature Anti-Cholera Toxin Llama VHH domain LAMA GLAMA lama glama Legler, P.M., Lam, A., Hol, W.G.J. 2.09 X-RAY DIFFRACTION 0.222 0.206 False True IGHV1 None None None None None 6u9s D E 0 F protein cd81 antigen CELL ADHESION 05/13/20 Crystal structure of human CD81 large extracellular loop in complex with 5A6 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Susa, K.J., Seegar, T.C.M., Blacklow, S.C.B., Kruse, A.C. 2.4 X-RAY DIFFRACTION 0.281 0.214 False True IGHV7 IGKV2 Kappa None None None None None 5xhv P Q 0 A protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 04/24/17 Crystal Structure Of Fab S40 In Complex With Influenza Hemagglutinin, HA1 subunit. INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/07/2009(h1n1)) Lee, C.C., Wang, A.H.J., Yu, C.M., Yang, A.S. 3.35 X-RAY DIFFRACTION 0.275 0.230 False True IGHV3 IGKV1 Kappa None None None None None 4tvp D E 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 06/27/14 Structure of BG505 SOSIP.664 in complex with broadly neutralizing antibodies, PGT122 and 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Zhou, T., Kwong, P.D. 3.1 X-RAY DIFFRACTION 0.248 0.214 False True unknown unknown unknown None None None None None 2ai0 J N 0 IMMUNE SYSTEM 07/28/05 Anti-Cocaine Antibody 7.5.21, Crystal Form III MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A., Ringe, D., Petsko, G.A. 2.2 X-RAY DIFFRACTION 0.279 0.222 False False IGHV5 IGKV1 Kappa None None None None None 6v8x C D 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/12/19 VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 3 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6ogx H L 0 G protein tumor necrosis factor receptor superfamily member 4 IMMUNE SYSTEM 04/03/19 Ternary complex of OX40R (TNFRSF4) bound to Fab1 and Fab2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M.H., Boenig, G., Harris, S.F. 2.77 X-RAY DIFFRACTION 0.254 0.203 False True IGHV1 IGKV1 Kappa None None None None None 6y92 C D 0 B protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN 03/06/20 Structure of full-length CD20 in complex with Ofatumumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kumar, A., Reyes, N. 4.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6s0y B NA 0 D peptide matrix protein 2 ANTIVIRAL PROTEIN 06/18/19 Nanobody targeting influenza A matrix protein 2 ectodomain (M2e) LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama influenza a virus (a/jeju/2279/2007(h1n1)) Van Molle, I., De Vlieger, D., Schepens, B., Remaut, H., Saelens, X. 1.81 X-RAY DIFFRACTION 0.225 0.187 False True IGHV1 None None None None None 6bgt B A 0 C protein receptor tyrosine-protein kinase erbb-2 TRANSFERASE/IMMUNE SYSTEM 10/29/17 Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain HOMO SAPIENS homo sapiens homo sapiens homo sapiens Christie, M., Christ, D. 2.7 X-RAY DIFFRACTION 0.248 0.205 False True IGHV3 IGKV1 Kappa None None None None None 6n48 B NA 0 A protein endolysin,beta-2 adrenergic receptor,beta-2 adrenergicreceptor chimera SIGNALING PROTEIN 11/17/18 Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator ENTEROBACTERIA PHAGE RB59; HOMO SAPIENS; CAMELIDAE camelidae enterobacteria phage rb59, homo sapiens Liu, X., Masoudi, A., Kahsai, A.W., Huang, L.Y., Pani, B., Hirata, K., Ahn, S., Lefkowitz, R.J., Kobilka, B.K. 3.2 X-RAY DIFFRACTION 0.274 0.251 False True IGHV1 None None None None None 7uds H L 0 C | c protein | protein NA | NA glycoprotein g2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 03/20/22 Structure of lineage I (Pinneo) Lassa virus glycoprotein bound to Fab 25.10C HOMO SAPIENS; LASSA MAMMARENAVIRUS homo sapiens homo sapiens lassa mammarenavirus | lassa mammarenavirus Buck, T.K., Enriquez, A.E., Hastie, K.M. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 2mkw NA A 0 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 5h35 A B 0 C protein membrane protein tric IMMUNE SYSTEM/MEMBRANE PROTEIN 10/20/16 Crystal structures of the TRIC trimeric intracellular cation channel orthologue from Sulfolobus solfataricus SULFOLOBUS SOLFATARICUS; MUS MUSCULUS mus musculus mus musculus sulfolobus solfataricus Kasuya, G., Hiraizumi, M., Hattori, M., Nureki, O. 2.642 X-RAY DIFFRACTION 0.252 0.211 False True IGHV5 IGKV1 Kappa None None None None None 6o8d H NA 0 C protein NA t-cell-specific surface glycoprotein cd28 IMMUNE SYSTEM 03/09/19 Anti-CD28xCD3 CODV Fab bound to CD28 HOMO SAPIENS homo sapiens homo sapiens Lord, D.M., Wei, R.R. 3.547 X-RAY DIFFRACTION 0.356 0.272 False True IGHV3 NA NA None None None None None 1ngx H L 0 H Hapten JEF JEFFAMINE IMMUNE SYSTEM 12/18/02 Chimeric Germline Fab 7g12 with jeffamine fragment bound MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Yin, J., Andryski, S.E., Beuscher, A.B., Stevens, R.C., Schultz, P.G. 1.8 X-RAY DIFFRACTION 0.250 0.225 False True IGHV1 IGKV6 Kappa None None None None None 1bre NA A 0 IMMUNOGLOBULIN 07/19/95 IMMUNOGLOBULIN LIGHT CHAIN PROTEIN HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 2.0 X-RAY DIFFRACTION 0.337 0.218 False True IGKV1 Kappa None None None None None 5iwl B b 0 C protein leukocyte surface antigen cd47 CELL ADHESION 03/22/16 CD47-diabody complex HOMO SAPIENS homo sapiens homo sapiens Di, W., Jude, K.M., Garcia, K.C. 2.8 X-RAY DIFFRACTION 0.267 0.221 True True unknown unknown unknown None None None None None 5um8 D E 0 B protein glycoprotein gp41 Viral Protein/Immune System 01/26/17 Crystal structure of HIV-1 envelope trimer 16055 NFL TF CC T(569)G in complex with Fabs 35022 and PGT124 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Garces, F., Stanfield, R.L., Wilson, I.A. 3.935 X-RAY DIFFRACTION 0.329 0.260 False True unknown unknown unknown None None None None None 7p5v J NA 0 D protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6p65 C D 0 B protein hiv env 16055 nfl td 2cc+ VIRAL PROTEIN/immune system 05/31/19 HIV Env 16055 NFL TD 2CC+ in complex with antibody 1C2 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.94 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 5eu7 E C 0 A protein integrase VIRAL PROTEIN 11/18/15 Crystal structure of HIV-1 integrase catalytic core in complex with Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Galilee, M., Griner, S.L., Stroud, R.M., Alian, A. 2.64 X-RAY DIFFRACTION 0.233 0.181 False True IGHV3 IGKV1 Kappa None None None None None 5w0k E F 0 C protein envelope glycoprotein h VIRAL PROTEIN/Immune system 05/31/17 Crystal structure of EBV gHgL/CL40/gp42 N-domain HUMAN HERPESVIRUS 4 (STRAIN B95-8); MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human herpesvirus 4 (strain b95-8) Sathiyamoorthy, K., Jardetzky, T.S. 3.1 X-RAY DIFFRACTION 0.299 0.242 False True IGHV1 IGKV6 Kappa 6.880000000000001e-08 -9.771277639060873 SPR TBD 4unu NA A 0 IMMUNE SYSTEM 05/30/14 MCG - a dimer of lambda variable domains HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C., Whitelegge, J., Casio, D., Sawaya, M.R., Eisenberg, D.S. 0.95 X-RAY DIFFRACTION 0.12996 0.10731 False True IGLV2 Lambda None None None None None 7mfv B NA 0 NA NA NA NA IMMUNE SYSTEM 04/11/21 Crystal structure of synthetic nanobody SYNTHETIC CONSTRUCT synthetic construct Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 1.9 X-RAY DIFFRACTION 0.258 0.228 False True IGHV1 NA NA None None None None None 3j3z H L 0 IMMUNE SYSTEM 05/21/13 Structure of MA28-7 neutralizing antibody Fab fragment from electron cryo-microscopy of enterovirus 71 complexed with a Fab fragment UNIDENTIFIED unidentified unidentified Lee, H., Cifuente, J.O., Ashley, R.E., Conway, J.F., Makhov, A.M., Tano, Y., Shimizu, H., Nishimura, Y., Hafenstein, S. 23.4 ELECTRON MICROSCOPY False False IGHV1 IGKV6 Kappa None None None None None 7m6d H L 0 C protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 03/25/21 Structure of the SARS-CoV-2 RBD in complex with neutralizing antibodies BG4-25 and CR3022 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.259 0.219 False True IGHV3 IGKV3 Kappa None None None None None 2h9g B A 0 R protein tumor necrosis factor receptor superfamily member 10bprecursor IMMUNE SYSTEM/APOTOSIS 06/09/06 Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G., Compaan, D.M. 2.32 X-RAY DIFFRACTION 0.282 0.228 False True IGHV3 IGKV1 Kappa 5.00e-09 -11.32 SPR 16859704 4fqr c d 0 C protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 3rif G K 0 C protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.345 X-RAY DIFFRACTION 0.271 0.248 False True IGHV1 IGLV1 Lambda None None None None None 4xc3 H L 0 P peptide modified fragment of hiv-1 glycoprotein (gp41) includingthe mper region 671-683 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41; crystals cryoprotected with rac-glycerol 1-phosphate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Stanfield, R.L., Wilson, I.A. 1.63 X-RAY DIFFRACTION 0.180 0.137 False True IGHV1 IGKV3 Kappa None None None None None 5wym C c 0 IMMUNE SYSTEM 01/13/17 Crystal structure of an anti-connexin26 scFv HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens, synthetic construct Li, S., Xu, L. 2.65 X-RAY DIFFRACTION 0.263 0.236 True True unknown unknown unknown None None None None None 6qgw B NA 0 A protein outer membrane protein assembly factor bama MEMBRANE PROTEIN 01/14/19 Crystal structure of E.coli BamA beta-barrel in complex with nanobody E6 ESCHERICHIA COLI O157:H7; LAMA GLAMA lama glama escherichia coli o157 Hartmann, J.-B., Kaur, H., Jakob, R.P., Zahn, M., Zimmermann, I., Seeger, M., Maier, T., Hiller, S. 1.938 X-RAY DIFFRACTION 0.230 0.189 False True IGHV1 None None None None None 7s6d D F 0 B protein NA 6-deoxyerythronolide-b synthase erya2, modules 3 and 4,lsd14 polyketide synthase fusion BIOSYNTHETIC PROTEIN 09/13/21 CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure SACCHAROPOLYSPORA ERYTHRAEA; STREPTOMYCES LASALOCIDI; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea, streptomyceslasalocidi Bagde, S.R., Kim, C.-Y., Fromme, J.C. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 7bei H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/20 Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-150 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Ren, J., Stuart, D. 2.3 X-RAY DIFFRACTION 0.232 0.184 False True IGHV3 IGKV1 Kappa None None None None None 6mxr H L 0 IMMUNE SYSTEM 10/31/18 Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M] HOMO SAPIENS homo sapiens homo sapiens Shi, R. 2.04 X-RAY DIFFRACTION 0.200 0.167 False True IGHV3 IGKV1 Kappa None None None None None 6a3w G H 0 I protein tumor necrosis factor receptor superfamily member 9 IMMUNE SYSTEM 06/17/18 Complex structure of 4-1BB and utomilumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F. 2.0 X-RAY DIFFRACTION 0.215 0.185 False True IGHV5 IGLV3 Lambda None None None None None 7deo C c 0 D protein NA spike protein s1 VIRAL PROTEIN/ANTIVIRAL PROTEIN 11/04/20 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens severe acute respiratory syndrome coronavirus2 Fu, D., Zhang, G., Li, X., Rao, Z., Guo, Y. 2.5 X-RAY DIFFRACTION 0.232 0.187 True True unknown unknown unknown None None None None None 6wg1 A B 0 C peptide NA npna6 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab399 in complex with NPNA6 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 2.086 X-RAY DIFFRACTION 0.246 0.197 False True IGHV3 IGKV2 Kappa None None None None None 6al4 D C 0 IMMUNE SYSTEM 08/07/17 CRYSTAL STRUCTURE OF ANTI-CD19 ANTIBODY B43 FAB HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.45 X-RAY DIFFRACTION 0.236 0.206 False True IGHV1 IGKV1 Kappa None None None None None 6cm3 P Q 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN 03/02/18 BG505 SOSIP in complex with sCD4, 17b, 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 3.54 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 7rth c NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 6n4q L K 0 C | D | H protein | protein | peptide NA | NA | NA nav1.7 vsd2-navab chimera | nav1.7 vsd2-navab chimera | beta/omega-theraphotoxin-tp2a MEMBRANE PROTEIN 11/20/18 CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2 ARCOBACTER BUTZLERI (STRAIN RM4018); HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus arcobacter butzleri (strain rm4018), homosapiens | arcobacter butzleri (strain rm4018), homosapiens | thrixopelma pruriens Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M. 3.6 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV4 Kappa None None None None None 1ar1 C D 0 B protein cytochrome c oxidase COMPLEX (OXIDOREDUCTASE/ANTIBODY) 08/08/97 STRUCTURE AT 2.7 ANGSTROM RESOLUTION OF THE PARACOCCUS DENITRIFICANS TWO-SUBUNIT CYTOCHROME C OXIDASE COMPLEXED WITH AN ANTIBODY FV FRAGMENT PARACOCCUS DENITRIFICANS; MUS MUSCULUS mus musculus mus musculus paracoccus denitrificans Ostermeier, C., Harrenga, A., Ermler, U., Michel, H. 2.7 X-RAY DIFFRACTION 0.261 0.207 False True IGHV5 IGKV12 Kappa None None None None None 3utz B A 0 IMMUNE SYSTEM 11/27/11 Endogenous-like inhibitory antibodies targeting activated metalloproteinase motifs show therapeutic potential MUS MUSCULUS Sela-Passwell, N., Kikkeri, R, Dym, O., Rozenberg, H, Margalit, R, Arad-Yellin, R., Eisenstein, M., Brenner, O., Shoham, T., Danon, T., Shanzer, A., Sagi, I., Israel Structural Proteomics Center (ISPC) 2.18 X-RAY DIFFRACTION 0.288 0.228 False True IGHV5 IGKV1 Kappa None None None None None 7cwl G J 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/29/20 SARS-CoV-2 spike protein and P17 fab complex with one RBD in close state SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, N. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6xm2 B A 0 L protein NA transforming growth factor beta-2 CYTOKINE/IMMUNE SYSTEM 06/29/20 The structure of the 4A11.v7 antibody in complex with human TGFb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lupardus, P.J., Yin, J.P. 1.91 X-RAY DIFFRACTION 0.244 0.205 False True IGHV4 IGKV3 Kappa None None None None None 6hjy H NA 0 C protein cys-loop ligand-gated ion channel MEMBRANE PROTEIN 09/04/18 X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72 DICKEYA CHRYSANTHEMI; LAMA GLAMA lama glama dickeya chrysanthemi Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C. 2.78 X-RAY DIFFRACTION 0.233 0.225 False True IGHV1 None None None None None 6ruv S NA 0 V | U protein | protein NA | NA properdin | properdin IMMUNE SYSTEM 05/29/19 Structure of the SCIN stabilized C3bBb convertase bound to Properdin and a the non-inhibitory nanobody hFPNb1 LAMA GLAMA; HOMO SAPIENS; STAPHYLOCOCCUS AUREUS lama glama homo sapiens | homo sapiens Pedersen, D.V., Andersen, G.R. 6.15 X-RAY DIFFRACTION 0.271 0.242 False True IGHV1 NA NA None None None None None 4qgy B NA 0 IMMUNE SYSTEM 05/26/14 Camelid (llama) nanobody n25 (VHH) against type 6 secretion system TssM protein LAMA GLAMA lama glama Nguyen, V.S., Desmyter, A., Le, T.T.H., Durand, E., Kellenberger, C., Douzi, B., Spinelli, S., Cascales, E., Cambillau, C., Roussel, A. 1.38 X-RAY DIFFRACTION 0.198 0.191 False True IGHV1 None None None None None 6ugv H L 0 IMMUNE SYSTEM 09/26/19 Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a I-centered orthorhombic crystal form, Lot C HOMO SAPIENS homo sapiens homo sapiens Lerch, T.F., Sharpe, P., Mayclin, S.J., Edwards, T.E., Polleck, S., Rouse, J.C., Conlan, H.D. 2.4 X-RAY DIFFRACTION 0.210 0.153 False True IGHV6 IGKV5 Kappa None None None None None 4s1d C D 0 H Hapten 41M N~6~-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}-L-lysinamide IMMUNE SYSTEM 01/13/15 Structure of IgG1 Fab fragment in complex with Biotincytidinamide MUS MUSCULUS mus musculus mus musculus mus musculus Dengl, S., Hoffmann, E., Grote, M., Wagner, C., Mundigl, O., Georges, G., Theorey, I., Stubenrauch, K.-G., Bujotzek, A., Josel, H.-P., Dziadek, S., Benz, J., Brinkmann, U. 2.5 X-RAY DIFFRACTION 0.274 0.225 False True IGHV14 IGKV12 Kappa None None None None None 6cnj I H 0 B | A protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 03/08/18 Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Walsh Jr, R.M., Roh, S.H., Gharpure, A., Morales-Perez, C.L., Teng, J., Hibbs, R.E. 3.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 7czz H K 0 A protein NA spike glycoprotein VIRAL PROTEIN 09/09/20 S protein of SARS-CoV-2 in complex bound with P5A-2F11_3B SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yan, R.H., Zhang, Y.Y., Li, Y.N., Zhou, Q. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7zf3 H L 0 E protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-3 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 3.15 X-RAY DIFFRACTION 0.266 0.208 False True IGHV3 IGKV1 Kappa None None None None None 7ps6 C D 0 E protein NA spike protein s1 VIRAL PROTEIN 09/22/21 Crystal structure of the receptor binding domain of SARS-CoV-2 beta variant spike glycoprotein in complex with Beta-44 and Beta-54 Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.26 X-RAY DIFFRACTION 0.240 0.215 False True IGHV1 IGLV2 Lambda None None None None None 7mxl A B 0 C protein NA major pollen allergen bet v 1-a ALLERGEN 05/19/21 Complex of Bet v 1 with the Fab fragments of a three antibody cocktail HOMO SAPIENS; BETULA PENDULA homo sapiens homo sapiens betula pendula Romero-Hernandez, A., Franklin, M.C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 43ca F E 0 E Hapten NPO P-NITROPHENOL IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY WITH BOUND P-NITROPHENOL MUS MUSCULUS mus musculus mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.3 X-RAY DIFFRACTION 0.259 0.206 False True IGHV2 IGKV8 Kappa None None None None None 6a0x E F 0 IMMUNE SYSTEM 06/06/18 Crystal structure of broadly neutralizing antibody 13D4 MUS MUSCULUS mus musculus mus musculus Li, S., Li, T. 2.3 X-RAY DIFFRACTION 0.243 0.205 False False IGHV1 IGKV6 Kappa None None None None None 6mwv C D 0 B protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-58 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 6c08 A B 0 C protein NA sodium-coupled neutral amino acid transporter 9 MEMBRANE PROTEIN 12/28/17 Zebrafish SLC38A9 with arginine bound in the cytosol open state DANIO RERIO; MUS MUSCULUS mus musculus mus musculus danio rerio Lei, H.-T., Gonen, T. 3.17 X-RAY DIFFRACTION 0.286 0.267 False False unknown unknown unknown None None None None None 4mxv Y X 0 D protein lymphotoxin-alpha CYTOKINE/IMMUNE SYSTEM 09/26/13 Structure of Lymphotoxin alpha bound to anti-LTa Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, J.P., Hymowitz, S.G. 3.2 X-RAY DIFFRACTION 0.235 0.177 False True IGHV3 IGKV1 Kappa None None None None None 7pi3 F G 0 A protein NA monoclonal antibody cy.004 heavy chain IMMUNE SYSTEM 08/19/21 PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 PLASMODIUM FALCIPARUM 3D7; GALLUS GALLUS gallus gallus gallus gallus plasmodium falciparum 3d7 Ragotte, R.J., Higgins, M.K. 3.269 X-RAY DIFFRACTION 0.298 0.285 False True unknown unknown unknown None None None None None 4m7l H L 0 T protein tissue factor BLOOD CLOTTING/IMMUNE SYSTEM 08/12/13 Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 3.4 X-RAY DIFFRACTION 0.289 0.242 False True IGHV1 IGKV8 Kappa None None None None None 6k67 NA C 0 D protein engineered calmodulin STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (9011-3LRH) HOMO SAPIENS homo sapiens homo sapiens Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.95 X-RAY DIFFRACTION 0.237 0.203 False True IGLV1 Lambda None None None None None 7u8m Q R 0 A protein NA hemagglutinin ha1 subunit VIRAL PROTEIN/Immune System 03/08/22 Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Zhu, X., Wilson, I.A. 5.39 X-RAY DIFFRACTION 0.342 0.304 False True IGHV4 IGKV1 Kappa None None None None None 5yoy G D 0 B protein tumor necrosis factor IMMUNE SYSTEM 10/31/17 Crystal structure of the human tumor necrosis factor in complex with golimumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N. 2.727 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV3 Kappa 1.8e-11 -14.658430977236662 Unknown TBD 3tje H L 0 F protein NA tumor necrosis factor receptor superfamily member 6 IMMUNE SYSTEM 08/24/11 Crystal structure of Fas receptor extracellular domain in complex with Fab E09 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zuger, S., Stirnimann, C., Briand, C., Grutter, M.G. 1.93 X-RAY DIFFRACTION 0.232 0.204 False True IGHV4 IGLV1 Lambda None None None None None 6vl8 C D 0 C Hapten PEU 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL IMMUNE SYSTEM 01/23/20 Anti-PEG antibody 6-3 Fab fragment in complex with PEG MUS MUSCULUS mus musculus mus musculus mus musculus Nicely, N.I., Huckaby, J.T., Lai, S.K., Jacobs, T.M. 2.42 X-RAY DIFFRACTION 0.240 0.185 False True IGHV9 IGKV8 Kappa None None None None None 5o02 C NA 0 A protein capsid protein VIRAL PROTEIN 05/16/17 GII.17 Kawasaki323 protruding domain in complex with Nanobody Nano-4 NOROVIRUS 13-BH-1/2013/GII.17; VICUGNA PACOS vicugna pacos norovirus 13-bh-1/2013/gii.17 Koromyslova, A.D., Hansman, G.S. 1.72 X-RAY DIFFRACTION 0.181 0.150 False True IGHV1 None None None None None 4xgz O P 0 o peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD2 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.245 0.228 False True IGHV3 IGKV1 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 6o29 A B 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein NPDP and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.240 0.201 False True IGHV3 IGKV3 Kappa None None None None None 4zyp H I 0 A protein fusion glycoprotein f0,fibritin IMMUNE SYSTEM 05/21/15 Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody AM14 in Complex with Prefusion RSV F Glycoprotein MUS MUSCULUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2), enterobacteria phage t4 Gilman, M.S.A., McLellan, J.S. 5.5 X-RAY DIFFRACTION 0.277 0.211 False True IGHV3 IGKV1 Kappa None None None None None 1cd0 NA A 0 IMMUNE SYSTEM 03/05/99 STRUCTURE OF HUMAN LAMDA-6 LIGHT CHAIN DIMER JTO HOMO SAPIENS homo sapiens Pokkuluri, P.R., Solomon, A., Weiss, D.T., Stevens, F.J., Schiffer, M. 1.9 X-RAY DIFFRACTION 0.240 0.184 False True IGLV6 Lambda None None None None None 7cw2 W V 0 e | d protein | protein NA | NA unknown | unknown VIRUS/IMMUNE SYSTEM 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263 (subregion around icosahedral 5-fold vertex) CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 4.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV5 Kappa None None None None None 4fq1 H L 0 IMMUNE SYSTEM 06/24/12 Crystal Structure of PGT121 Fab HOMO SAPIENS homo sapiens homo sapiens Scharf, L., Bjorkman, P.J. 3.0 X-RAY DIFFRACTION 0.264 0.216 False True IGHV4 unknown unknown None None None None None 3cfj H L 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, orthorhombic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.253 0.199 False True IGHV4 IGLV1 Lambda None None None None None 6suz H L 0 A protein NA major prion protein PROTEIN BINDING 09/17/19 Human prion protein (PrP) fragment 119-231 (G127V V129 variant) complexed to ICSM 18 (anti-Prp therapeutic antibody) Fab fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Conners, R. 2.5 X-RAY DIFFRACTION 0.212 0.161 False False IGHV1 IGKV4 Kappa None None None None None 6oej H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 03/27/19 CRYSTAL STRUCTURE OF THE NON-NEUTRALIZING AND ADCC-POTENT ANTIBODY C11 IN COMPLEX WITH HIV-1 CLADE A/E GP120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 3.45 X-RAY DIFFRACTION 0.284 0.231 False True IGHV3 IGKV2 Kappa None None None None None 5mvz A B 0 V protein interleukin-1 beta SIGNALING PROTEIN 01/17/17 Fab 4AB007 bound to Interleukin-1-beta HOMO SAPIENS homo sapiens homo sapiens homo sapiens Stark, W., Seibert, V. 2.15 X-RAY DIFFRACTION 0.281 0.219 False True IGHV5 IGKV3 Kappa None None None None None 6nn3 H L 0 A protein vp2 of b19 parvovirus VIRUS LIKE PARTICLE 01/14/19 Structure of parvovirus B19 decorated with Fab molecules from a human antibody HUMAN PARVOVIRUS B19; HOMO SAPIENS homo sapiens homo sapiens human parvovirus b19 Rossmann, M.G., Sun, Y., Klose, T., Liu, Y. 3.22 ELECTRON MICROSCOPY False False IGHV4 IGLV3 Lambda None None None None None 1kem H L 0 CATALYTIC ANTIBODY 04/16/96 CATALYTIC ANTIBODY 28B4 FAB FRAGMENT MUS MUSCULUS mus musculus mus musculus Hsieh-Wilson, L.C., Schultz, P.G., Stevens, R.C. 2.2 X-RAY DIFFRACTION 0.288 0.183 False False IGHV7 IGKV1 Kappa None None None None None 5tlk D C 0 X protein cd27 antigen IMMUNE SYSTEM 10/11/16 COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191 HOMO SAPIENS; MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.7 X-RAY DIFFRACTION 0.263 0.213 False True IGHV3 IGKV1 Kappa None None None None None 6dfh G J 0 C protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 05/14/18 BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Steichen, J.M., Schief, W.R., Ward, A.B. 3.85 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 5l88 H L 0 L carbohydrate NAG polysaccharide IMMUNE SYSTEM 06/07/16 AFAMIN ANTIBODY FRAGMENT, N14 FAB, L1- GLYCOSILATED, CRYSTAL FORM I, non-parsimonious model MUS MUSCULUS mus musculus mus musculus mus musculus Rupp, B., Naschberger, A. 1.88 X-RAY DIFFRACTION 0.211 0.170 False False IGHV1 IGKV4 Kappa None None None None None 4ods H L 0 IMMUNE SYSTEM 01/10/14 Unliganded Fab structure of lipid A-specific antibody S55-3 MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 1.94 X-RAY DIFFRACTION 0.258 0.210 False False IGHV5 IGKV3 Kappa None None None None None 4c83 C D 0 C carbohydrate NDG polysaccharide IMMUNE SYSTEM 09/29/13 Crystal Structure of the IgG2a LPT3 in complex with an 8-sugar inner core analogue of Neisseria meningitidis MUS MUSCULUS mus musculus mus musculus mus musculus Parker, M.J., Gomery, K., Richard, G., Mackenzie, C.R., Cox, A.D., Richards, J.C., Evans, S.V. 2.69 X-RAY DIFFRACTION 0.29255 0.22484 False False IGHV5 IGKV4 Kappa None None None None None 7c01 C D 0 B protein sars-cov-2 spike protein s1 VIRAL PROTEIN 05/27/20 Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Shi, R., Qi, J., Wang, Q., Gao, F.G., Yan, J. 2.88 X-RAY DIFFRACTION 0.265 0.218 False True IGHV3 IGKV1 Kappa None None None None None 6quz F NA 0 D | C protein | protein NA | NA uncharacterized abc transporter atp-binding proteintm_0288 | abc transporter, atp-binding protein MEMBRANE PROTEIN 03/01/19 Structure of ATPgS-bound outward-facing TM287/288 in complex with sybody Sb_TM35 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); SYNTHETIC CONSTRUCT synthetic construct thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) | thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 3.21 X-RAY DIFFRACTION 0.263 0.243 False True IGHV1 NA NA None None None None None 2kqm NA A 16 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 4fqk H L 0 A protein hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dreyfus, C., Laursen, N.S., Wilson, I.A. 5.65 X-RAY DIFFRACTION 0.324 0.306 False True IGHV1 IGLV1 Lambda None None None None None 6rcv C B 0 A protein reticulocyte binding protein homologue 5 CELL ADHESION 04/11/19 PfRH5 bound to monoclonal antibodies R5.011 and R5.016 PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Alanine, D.W.G., Draper, S.J., Higgins, M.K. 3.582 X-RAY DIFFRACTION 0.305 0.280 False True IGHV7 IGLV3 Lambda None None None None None 7xjk E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(q) | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 04/18/22 Cryo-EM structure of the galanin-bound GALR2-miniGq complex Homo sapiens homo sapiens homo sapiens | homo sapiens Jiang, W., Zheng, S. 0 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 2dqf E D 0 F protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/25/06 Crystal structure of hyhel-10 FV mutant (y33ay53a) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 2.5 X-RAY DIFFRACTION 0.268 0.224 False True IGHV3 IGKV5 Kappa None None None None None 7vnd V NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 10/10/21 Structure of the SARS-CoV-2 spike glycoprotein in complex with a human single domain antibody n3113 (UUD-state, state 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Yang, Z., Wang, Y., Kong, Y., Jin, Y., Wu, Y., Ying, T. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4nuj B A 0 IMMUNE SYSTEM 12/03/13 Crystal structure of HIV-1 broadly neutralizing antibody PGT152 HOMO SAPIENS homo sapiens homo sapiens Blattner, C., Wilson, I.A. 1.827 X-RAY DIFFRACTION 0.210 0.168 False True IGHV3 IGKV2D Kappa None None None None None 3mlt B A 0 C peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 2.49 X-RAY DIFFRACTION 0.280 0.202 False False IGHV5 IGLV3 Lambda None None None None None 6jp7 H L 0 L Hapten 3FX (2R)-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPANE-1-SULFONIC ACID VIRAL PROTEIN/IMMUNE SYSTEM 03/26/19 Human antibody 32D6 Fab in complex with PEG HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 1.909 X-RAY DIFFRACTION 0.214 0.169 False True IGHV4 IGLV4 Lambda None None None None None 2mkw NA A 5 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 2v7n D C 0 IMMUNE SYSTEM 07/31/07 Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4 SYNTHETIC CONSTRUCT synthetic construct synthetic construct Frey, D., Huber, T., Plueckthun, A., Gruetter, M.G. 1.92 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV3 Kappa None None None None None 7lr3 H L 0 D protein NA hapless 2 SURFACTANT PROTEIN/IMMUNE SYSTEM 02/15/21 Complex of Fab 2/6.14 with domain 3 of P. berghei HAP2 MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Feng, J., Dong, X.C., Lu, X.F., Springer, T.A. 2.8 X-RAY DIFFRACTION 0.292 0.253 False True IGHV5 IGKV19 Kappa None None None None None 5y2m K L 0 E | B protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 07/26/17 Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the H4N6 duck isolate (H4-CZ/56) hemagglutinin INFLUENZA A VIRUS (STRAIN A/DUCK/CZECHOSLOVAKIA/1956 H4N6); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (straina/duck/czechoslovakia/1956 h4n6) | influenza a virus (straina/duck/czechoslovakia/1956 h4n6) Xiao, H., Qi, J., Gao, F.G. 3.8 X-RAY DIFFRACTION 0.277 0.236 False True IGHV3 IGKV3 Kappa None None None None None 5gs1 B A 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 False True IGHV3 IGKV3 Kappa None None None None None 5gks C D 0 IMMUNE SYSTEM 07/05/16 Crystal structure of SLE patient-derived anti-DNA antibody HOMO SAPIENS homo sapiens homo sapiens Arimori, T., Sakakibara, S., Kikutani, H., Takagi, J. 2.05 X-RAY DIFFRACTION 0.255 0.217 False True IGHV4 IGLV2 Lambda None None None None None 6v4q H L 0 NA NA NA NA IMMUNE SYSTEM 11/28/19 Crystal structure of a MR78-like antibody naive-1 Fab HOMO SAPIENS homo sapiens homo sapiens Bozhanova, N.G., Crowe, J.E., Meiler, J. 1.39 X-RAY DIFFRACTION 0.187 0.165 False True IGHV3 IGKV1 Kappa None None None None None 1q9o D C 0 IMMUNE SYSTEM 08/25/03 S45-18 Fab Unliganded MUS MUSCULUS mus musculus mus musculus Nguyen, H.P., Seto, N.O., MacKenzie, C.R., Brade, L., Kosma, P., Brade, H., Evans, S.V. 1.79 X-RAY DIFFRACTION 0.247 0.220 False False IGHV7 IGKV8 Kappa None None None None None 5ggq H L 0 IMMUNE SYSTEM 06/16/16 Crystal structure of Nivolumab Fab fragment homo sapiens homo sapiens Heo, Y.S. 1.9 X-RAY DIFFRACTION 0.226 0.196 False True IGHV3 IGKV3 Kappa None None None None None 6qd6 C NA 0 STRUCTURAL PROTEIN 12/31/18 Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 HELICOBACTER PYLORI; HELICOBACTER PYLORI (STRAIN G27) helicobacter pylori, helicobacter pylori(strain g27) Uchanski, T., Masiulis, S., Fischer, B., Kalichuk, V., Wohlkonig, A., Zogg, T., Remaut, H., Vranken, W., Aricescu, A.R., Pardon, E., Steyaert, J. 2.84 X-RAY DIFFRACTION 0.239 0.204 False True IGHV1 None None None None None 6ju0 H L 0 H Hapten TOE 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL IMMUNE SYSTEM 04/12/19 Mouse antibody 3.3 Fab in complex with PEG MUS MUSCULUS mus musculus mus musculus mus musculus Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 2.601 X-RAY DIFFRACTION 0.240 0.211 False True IGHV6 IGKV4 Kappa None None None None None 5xrq A B 0 IMMUNE SYSTEM 06/09/17 Crystal structure of human monoclonal antibody H3v-47 HOMO SAPIENS homo sapiens homo sapiens Zhang, H., Willson, I.A. 2.6 X-RAY DIFFRACTION 0.214 0.180 False True IGHV1 IGKV3 Kappa None None None None None 6x5e H L 0 NA NA NA NA IMMUNE SYSTEM 05/26/20 Crystal structure of a Lewis-binding Fab (ch88.2) MUS MUSCULUS mus musculus mus musculus Soliman, C., Ramsland, P.A. 2.29 X-RAY DIFFRACTION 0.284 0.230 False True IGHV6 IGKV12 Kappa None None None None None 6qkd K NA 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGHV1 None None None None None 4nkm C D 0 IMMUNE SYSTEM/CHAPERONE 11/12/13 Crystal structure of engineered anti-EE scFv antibody fragment MUS MUSCULUS mus musculus mus musculus Kalyoncu, S., Hyun, J., Pai, J.C., Johnson, J.L., Etzminger, K., Jain, A., Heaner Jr., D., Molares, I.A., Truskett, T.M., Maynard, J.A., Lieberman, R.L. 3.71 X-RAY DIFFRACTION 0.282 0.264 False True IGHV1 IGKV1 Kappa None None None None None 7czd C NA 0 D protein NA programmed cell death 1 ligand 1 IMMUNE SYSTEM 09/08/20 Crystal structure of PD-L1 in complex with a VHH LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Wang, C. 1.64 X-RAY DIFFRACTION 0.184 0.150 False True IGHV3 NA NA None None None None None 6oq7 C NA 0 A protein toxin b TOXIN 04/25/19 Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH E3 CLOSTRIDIOIDES DIFFICILE; CAMELIDAE camelidae clostridioides difficile Chen, P., Lam, K., Jin, R. 2.39 X-RAY DIFFRACTION 0.236 0.197 False True unknown unknown unknown None None None None None 6wi9 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/09/20 Human secretin receptor Gs complex HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Belousoff, M.J., Khoshouei, M. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4y5x J K 0 L protein erythropoietin receptor protein binding/immune system 02/12/15 Diabody 305 complex with EpoR HOMO SAPIENS homo sapiens homo sapiens homo sapiens Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C. 3.15 X-RAY DIFFRACTION 0.241 0.201 False True IGHV3 IGLV1 Lambda None None None None None 7rks I M 0 S protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 07/22/21 Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C118 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus Jette, C.A., Bjorkman, P.J., Barnes, C.O. 2.7 X-RAY DIFFRACTION 0.247 0.195 False True IGHV3 IGLV4 Lambda None None None None None 7evm N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 STRUCTURAL PROTEIN 05/21/21 Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex HOMO SAPIENS; RATTUS NORVEGICUS; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | rattus norvegicus Cong, Z., Chen, L., Ma, H., Zhou, Q., Zou, X., Ye, C., Dai, A., Liu, Q., Huang, W., Sun, X., Wang, X., Xu, P., Zhao, L., Xia, T., Zhong, W., Yang, D., Xu, H.E., Zhang, Y., Wang, M. 2.5 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6mw9 K L 0 J protein NA e2 VIRUS/IMMUNE SYSTEM 10/29/18 CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-3 antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 7.3 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 7wkd E e 0 A | B protein | protein NA | NA gq | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 HORMONE 01/09/22 TRH-TRHR G protein complex HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens Xu, Y., Cai, H., You, C., He, X., Yuan, Q., Jiang, H., Cheng, X., Jiang, Y., Xu, H.E. 3.01 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 3klh D C 0 B protein p51 rt TRANSFERASE/DNA 11/07/09 Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P) HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus type 1 Tu, X., Sarafianos, S.G., Arnold, E. 2.9 X-RAY DIFFRACTION 0.294 0.260 False True IGHV8 IGKV10 Kappa None None None None None 5w06 H L 0 T protein tissue factor IMMUNE SYSTEM 05/30/17 HUMAN TISSUE FACTOR IN COMPLEX WITH ANTIBODY M1587 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Teplyakov, A., Obmolova, G., Malia, T.J., Gilliland, G.L. 2.6 X-RAY DIFFRACTION 0.235 0.186 False True IGHV5 IGKV2 Kappa 1.4000000000000003e-10 -13.443086585131377 SPR TBD 3whe Q R 0 C protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 2p8p B A 0 C peptide gp41 peptide viral protein 03/22/07 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LELDKWASLW[N-Ac] HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Bryson, S., Julien, J.-P., Pai, E.F. 2.7 X-RAY DIFFRACTION 0.266 0.238 False False IGHV2 IGKV1 Kappa None None None None None 7kzz F E 0 B protein NA cadmium and zinc efflux pump fief MEMBRANE PROTEIN 12/10/20 Cryo-EM structure of YiiP-Fab complex in Holo state SHEWANELLA ONEIDENSIS; HOMO SAPIENS homo sapiens homo sapiens shewanella oneidensis Lopez-Redondo, M.L., Fan, S., Koide, A., Koide, S., Beckstein, O., Stokes, D.L. 3.42 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7ew5 E F 0 A protein NA light chain of 13h5 VIRAL PROTEIN 05/24/21 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 HUMAN PAPILLOMAVIRUS TYPE 6; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 6 Wang, Z.P., Wang, D.N., Gu, Y., Li, S.W. 3.606 X-RAY DIFFRACTION 0.293 0.252 False False IGHV14 IGKV6 Kappa None None None None None 1j1o H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 12/13/02 Crystal Structure of HyHEL-10 Fv mutant LY50F complexed with hen egg white lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Yokota, A., Tsumoto, K., Shiroishi, M., Kondo, H., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.215 0.190 False True IGHV3 IGKV5 Kappa None None None None None 6v6w I J 0 G protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 12/06/19 Crystal structure of antibody 438-B11 DSS mutant (Cys98A-100aA) in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 human immunodeficiency virus 1 human immunodeficiency virus 1 Kumar, S., Wilson, I.A. 6.5 X-RAY DIFFRACTION 0.355 0.309 False True unknown IGKV3 Kappa None None None None None 2qtj A L 4 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4yhp A B 0 IMMUNE SYSTEM 02/27/15 Crystal structure of 309M3-B Fab in complex with H3K9me3 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Hattori, T., Dementieva, I.S., Montano, S.P., Koide, S. 2.53 X-RAY DIFFRACTION 0.250 0.211 False True IGHV3 IGLV3 Lambda 2e-09 -11.867518412372508 Unknown TBD 1dvf D C 0 COMPLEX (IDIOTOPE-ANTIIDIOTOPE) 04/13/96 IDIOTOPIC ANTIBODY D1.3 FV FRAGMENT-ANTIIDIOTOPIC ANTIBODY E5.2 FV FRAGMENT COMPLEX MUS MUSCULUS mus musculus mus musculus Braden, B.C., Fields, B.A., Ysern, X., Dall'Acqua, W., Goldbaum, F.A., Poljak, R.J., Mariuzza, R.A. 1.9 X-RAY DIFFRACTION 0.249 0.194 False True IGHV14 IGKV10 Kappa None None None None None 7mzj H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 93 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.4 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGKV1 Kappa None None None None None 6b3s J K 0 I protein epidermal growth factor receptor TRANSFERASE/immune system 09/23/17 Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Bagchi, A. 2.8 X-RAY DIFFRACTION 0.245 0.208 False True IGHV4 IGKV3 Kappa 1.2000000000000002e-08 -10.805930168369423 SPR TBD 5ies H L 0 C protein germline-targeting hiv-1 gp120 engineered outer domain eod-gt8 IMMUNE SYSTEM/ VIRAL PROTEIN 02/25/16 Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.16 A HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sarkar, A., Wilson, I.A. 2.16 X-RAY DIFFRACTION 0.214 0.189 False True IGHV1 IGKV4 Kappa 3.6799999999999996e-07 -8.77775408374075 SPR TBD 6n1v M N 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6qtl A NA 0 A Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 7o52 H L 0 U protein NA cd22 d6-d7 ig domains IMMUNE SYSTEM 04/07/21 CD22 d6-d7 in complex with Fab m971 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ereno-Orbea, J., Sicard, T., Julien, J.P. 2.41 X-RAY DIFFRACTION 0.264 0.226 False True IGHV6 IGKV1 Kappa None None None None None 2vwe L J 0 B protein vascular endothelial growth factor b IMMUNE SYSTEM 06/23/08 Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Leonard, P., Scotney, P.D., Jabeen, T., Iyer, S., Fabri, L.J., Nash, A.D., Acharya, K.R. 3.4 X-RAY DIFFRACTION 0.310 0.262 False True IGHV1 IGKV10 Kappa 1.14e-10 -13.56 SPR 18930733 5muq A B 0 IMMUNE SYSTEM 01/13/17 Crystal structure of DC8E8 Fab at pH 7.0 containing a Zn atom MUS MUSCULUS mus musculus mus musculus Skrabana, R., Novak, M., Cehlar, O., Kontsekova, E. 2.62 X-RAY DIFFRACTION 0.279 0.212 False False IGHV1 IGKV8 Kappa None None None None None 4why G H 0 D peptide epitope peptide VIRAL PROTEIN 09/24/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P21 crystal form RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.62 X-RAY DIFFRACTION 0.258 0.204 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 6vpx H L 0 G peptide NA mper peptide VIRAL PROTEIN/IMMUNE SYSTEM 02/04/20 Nanodisc of full-length HIV-1 Envelope glycoprotein clone AMC011 in complex with one PGT151 Fab and three 10E8 Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rantalainen, K., Ward, A.B.W. 5.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7mzh H L 0 E protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 119 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Tan, L.L., Dietrich, M.H., Chan, L.J., Tham, W.H. 2.1 X-RAY DIFFRACTION 0.265 0.220 False True IGHV1 IGLV1 Lambda None None None None None 6f0d A NA 0 IMMUNE SYSTEM 11/19/17 Crystal structure of a llama VHH antibody BCD090-M2 against human ErbB3 in space group P1 with cadmium ions LAMA GLAMA lama glama Eliseev, I.E., Yudenko, A.N., Vysochinskaya, V.V., Svirina, A.A., Evstratyeva, A.V., Drozhzhachih, M.S., Krendeleva, E.A., Vladimirova, A.K., Nemankin, T.A., Ekimova, V.M., Ulitin, A.B., Lomovskaya, M.I., Yakovlev, P.A., Moiseenko, F.V., Chakchir, O.B. 1.90001 X-RAY DIFFRACTION 0.218 0.174 False True IGHV1 None None None None None 5wob K L 0 B protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 3ogo E NA 0 A protein green fluorescent protein FLUORESCENT PROTEIN/IMMUNE SYSTEM 08/17/10 Structure of the GFP:GFP-nanobody complex at 2.8 A resolution in spacegroup P21212 AEQUOREA VICTORIA; CAMELUS DROMEDARIUS camelus dromedarius aequorea victoria Kubala, M.H., Kovtun, O., Alexandrov, K., Collins, B.M. 2.8 X-RAY DIFFRACTION 0.253 0.202 False True IGHV1 1.40e-09 -12.56 Other 37 20945358 2fjf R Q 0 IMMUNE SYSTEM 01/02/06 Structure of the G6 Fab, a phage derived VEGF binding Fab HOMO SAPIENS homo sapiens homo sapiens Wiesmann, C. 2.65 X-RAY DIFFRACTION 0.248 0.199 False True IGHV3 IGKV1 Kappa None None None None None 6x1t C D 0 O peptide NA nm23-1-ptza peptide IMMUNE SYSTEM 05/19/20 Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Kalagiri, R., Stanfield, R.L., Wilson, I.A., Hunter, T. 2.34 X-RAY DIFFRACTION 0.269 0.244 False True IGHV1 IGKV1 Kappa None None None None None 6p67 C D 0 J protein NA interleukin-7 receptor subunit alpha IMMUNE SYSTEM 06/03/19 Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Walsh, S.T.R., Kashi, L., Kohnhorst, C.L. 2.9 X-RAY DIFFRACTION 0.266 0.249 False True IGHV1 IGKV6 Kappa None None None None None 7lf7 A B 0 M protein NA apolipoprotein l1 IMMUNE SYSTEM 01/15/21 Fab 6D12 bound to ApoL1 NTD HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Kirchhofer, D. 2.026 X-RAY DIFFRACTION 0.217 0.189 False True IGHV5 IGKV16 Kappa None None None None None 5fha H L 0 IMMUNE SYSTEM 12/21/15 Crystal Structure of Protective Ebola Virus Antibody 114 HOMO SAPIENS homo sapiens homo sapiens Gilman, M.S.A., McLellan, J.S. 1.973 X-RAY DIFFRACTION 0.230 0.179 False True IGHV3 IGKV1 Kappa None None None None None 7rk1 C c 0 A protein NA capsid polyprotein vp70 VIRAL PROTEIN 07/21/21 Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 3E8, an astrovirus-neutralizing antibody, at 2.05-A resolution HUMAN ASTROVIRUS-8; MUS MUSCULUS mus musculus human astrovirus-8 Meyer, L., DuBois, R.M. 2.05 X-RAY DIFFRACTION 0.238 0.223 True True unknown unknown unknown None None None None None 5ihl B NA 0 A protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 02/29/16 STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB HOMO SAPIENS homo sapiens homo sapiens Sheriff, S. 3.3 X-RAY DIFFRACTION 0.298 0.268 False True IGHV3 None None None None None 5eii H L 0 G protein histone chaperone asf1 IMMUNE SYSTEM 10/29/15 Structural determination of an protein complex of a Fab with increased solubility HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Bailey, L.J., Kossiakoff, A.A., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS) 2.44 X-RAY DIFFRACTION 0.233 0.185 False True IGHV3 IGKV1 Kappa None None None None None 1rz8 D C 0 IMMUNE SYSTEM 12/24/03 CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B HOMO SAPIENS homo sapiens homo sapiens Huang, C.C., Venturi, M., Majeed, S., Moore, M.J., Phogat, S., Zhang, M.-Y., Dimitrov, D.S., Hendrickson, W.A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., Farzan, M., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.262 0.212 False True IGHV1 IGKV3 Kappa None None None None None 7mf7 E F 0 NA NA NA NA IMMUNE SYSTEM 04/08/21 Crystal structure of antibody 10E8v4-P100gA Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Kwong, P.D. 2.0 X-RAY DIFFRACTION 0.231 0.203 False True IGHV3 IGLV3 Lambda None None None None None 5f7w C NA 0 A protein adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/08/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group B Lewis b heptasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.81 X-RAY DIFFRACTION 0.208 0.171 False True IGHV1 None None None None None 7cvy S T 0 Q protein NA e2 glycoprotein IMMUNE SYSTEM/VIRUS 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124 MUS MUSCULUS; CHIKUNGUNYA VIRUS mus musculus mus musculus chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 5.2 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 3uji H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 11/07/11 Crystal structure of anti-HIV-1 V3 Fab 2558 in complex with MN peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hiv-1 m Kong, X.P. 1.6 X-RAY DIFFRACTION 0.194 0.161 False False IGHV5 IGLV3 Lambda None None None None None 7om5 B NA 0 NA NA NA NA IMMUNE SYSTEM 05/21/21 Anti-EGFR nanobody EgB4 LAMA GLAMA lama glama Zeronian, M.R., Janssen, B.J.C. 1.48 X-RAY DIFFRACTION 0.205 0.177 False True IGHV1 NA NA None None None None None 4qhm E F 0 IMMUNE SYSTEM 05/28/14 I3.1 (unbound) from CH103 Lineage HOMO SAPIENS homo sapiens homo sapiens Fera, D., Harrison, S.C. 3.23 X-RAY DIFFRACTION 0.251 0.224 False True IGHV4 IGLV3 Lambda None None None None None 3cfk H L 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 5itf D C 0 IMMUNE SYSTEM 03/16/16 Cetuximab Fab in complex with 2-bromophenylalanine meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.51 X-RAY DIFFRACTION 0.223 0.184 False True IGHV2 IGKV5 Kappa 1.8e-06 -7.837210530185391 Unknown TBD 7daa H L 0 A protein NA isoform 2 of basigin CHAPERONE 10/16/20 Crystal structure of basigin complexed with anti-basigin Fab fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Sakuragi, T., Kanai, R., Narita, H., Onishi, E., Miyazaki, T., Baba, T., Nakagawa, A., Toyoshima, C., Nagata, S. 2.51 X-RAY DIFFRACTION 0.283 0.228 False True IGHV1 IGKV1 Kappa None None None None None 4wht K L 0 k peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 6n1v H L 0 D protein envelope glycoprotein gp41 VIRAL PROTEIN 11/12/18 Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody A12V163-a.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 4 ELECTRON MICROSCOPY False True IGHV4 IGLV1 Lambda None None None None None 7lka E F 0 NA NA NA NA IMMUNE SYSTEM 02/02/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 1.981 X-RAY DIFFRACTION 0.264 0.215 False True IGHV3 IGKV1 Kappa None None None None None 6hjq I J 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/04/18 Structure of Full-length Influenza Hemagglutinin (A/duck/Alberta/35/76) in complex with FISW84 Fab Fragment HOMO SAPIENS; INFLUENZA A VIRUS (STRAIN A/DUCK/ALBERTA/35/1976 H1N1) homo sapiens homo sapiens influenza a virus (straina/duck/alberta/35/1976 h1n1) | influenza a virus (straina/duck/alberta/35/1976 h1n1) Benton, D.J., Rosenthal, P.B. 4.1 ELECTRON MICROSCOPY False True IGHV3 IGKV3 Kappa None None None None None 4ffz Z Y 0 X protein envelope protein e IMMUNE SYSTEM/VIRAL PROTEIN 06/01/12 Crystal Structure of DENV1-E111 fab fragment bound to DENV-1 DIII (Western Pacific-74 strain). DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Austin, S.K., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.8 X-RAY DIFFRACTION 0.278 0.237 False False IGHV1 IGKV3 Kappa 4.16e-07 -8.705114208770938 SPR TBD 1qkz H L 0 P peptide major outer membrane protein p1.16 IMMUNE SYSTEM 08/17/99 Fab fragment (MN14C11.6) in complex with a peptide antigen derived from Neisseria meningitidis P1.7 serosubtype antigen and domain II from Streptococcal protein G STREPTOCOCCUS SP.; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Derrick, J.P., Feavers, I., Maiden, M.C.J. 1.95 X-RAY DIFFRACTION 0.262 0.205 False False IGHV5 IGKV1 Kappa None None None None None 5o14 H L 0 A protein factor h binding protein variant 1.1 IMMUNE SYSTEM 05/18/17 Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein NEISSERIA MENINGITIDIS SEROGROUP B (STRAIN MC58); HOMO SAPIENS homo sapiens homo sapiens neisseria meningitidis serogroup b (strainmc58) Lopez-Sagaseta, J. 2.195 X-RAY DIFFRACTION 0.250 0.192 False True IGHV5 IGKV1 Kappa None None None None None 1yed H L 0 L Hapten PNB 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE CATALYTIC ANTIBODY 04/15/97 STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4) MUS MUSCULUS mus musculus mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.1 X-RAY DIFFRACTION 0.260 0.215 False False IGHV1 IGKV1 Kappa None None None None None 3kym P O 0 IMMUNE SYSTEM 12/06/09 Crystal structure of Li33 IgG2 di-Fab HOMO SAPIENS homo sapiens homo sapiens Silvian, L.F., Pepinsky, R.B., Walus, L. 2.62 X-RAY DIFFRACTION 0.339 0.259 False True IGHV3 IGKV3 Kappa None None None None None 6mar M N 0 B | A | F protein | protein | protein NA | NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 | envelope glycoprotein gp160 MEMBRANE PROTEIN 08/28/18 HIV-1 Envelope Glycoprotein Clone BG505 delCT N332T in complex with broadly neutralizing antibody Fab PGT151 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T., Ward, A.B. 4.5 ELECTRON MICROSCOPY False True IGHV3 IGKV2 Kappa None None None None None 1kcr H L 0 P peptide ps1 peptide IMMUNE SYSTEM 11/11/01 CRYSTAL STRUCTURE OF ANTIBODY PC283 IN COMPLEX WITH PS1 PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Nair, D.T., Singh, K., Sahu, N., Rao, K.V.S., Salunke, D.M. 2.9 X-RAY DIFFRACTION 0.277 0.184 False False IGHV3 IGKV6 Kappa None None None None None 6c6z H L 0 B protein spike protein IMMUNE SYSTEM 01/19/18 Crystal structure of potent neutralizing antibody CDC2-C2 in complex with MERS-CoV S1 RBD MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Wang, N., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.228 0.191 False True IGHV1 IGKV2 Kappa None None None None None 7m1h E NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/13/21 Crystal structure of LC/A-JPU-C10-JPU-D12-JPU-B8-JPU-G3-ciA-F12-ciA-D12 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.78 X-RAY DIFFRACTION 0.249 0.217 False True unknown unknown unknown None None None None None 7oaq F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody H3 AND C1 bound to RBD with Kent mutation LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 Naismith, J.H., Mikolajek, H. 1.55 X-RAY DIFFRACTION 0.178 0.155 False False IGHV1 NA NA None None None None None 7o85 NA T 0 S | U protein | protein NA | NA protective antigen pa-63 | fab TOXIN 04/14/21 Anthrax toxin prepore in complex with the neutralizing Fab cAb29 BACILLUS ANTHRACIS; MUS MUSCULUS mus musculus bacillus anthracis | mus musculus Hoelzgen, F., Zalk, R., Alcalay, R., Cohen-Schwartz, S., Garau, G., Shahar, A., Mazor, O., Frank, G.A. 3.3 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7rby D NA 0 C protein NA spike protein s1 VIRAL PROTEIN 07/06/21 Crystal structure of Nanobody nb112 and SARS-CoV-2 RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Chen, Y., Tolbert, W., Pazgier, M. 2.82 X-RAY DIFFRACTION 0.287 0.201 False True IGHV1 NA NA None None None None None 5jof C D 0 IMMUNE SYSTEM 05/02/16 Crystal structure of VRC03 gHVgLV antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Joyce, M.G., Mascola, J.R., Kwong, P.D. 3.208 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 IGKV3 Kappa None None None None None 7rsn E J 0 C protein NA amc018 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/11/21 AMC018 SOSIP.v4.2 in complex with PGV04 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Ward, A.B. 3.49 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 6kr0 A a 0 NA NA NA NA IMMUNE SYSTEM 08/20/19 Crystal structure of HL homo-diabody HOMO SAPIENS homo sapiens Tanaka, Y. 2.3 X-RAY DIFFRACTION 0.226 0.202 True True unknown unknown unknown None None None None None 6x97 H L 0 A protein NA bg505 hiv-1 env gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/02/20 Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11A fragment antigen binding variable domain HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Ozorowski, G., Cottrell, C.A., Ward, A.B. 3.65 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5hd8 E F 0 B protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 01/05/16 Crystal structure of disulfide cross-linked D417C ClC-ec1 ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Mathews, I.I., Khantwal, C.M., Maduke, M. 3.15 X-RAY DIFFRACTION 0.257 0.205 False True IGHV4 IGKV4 Kappa None None None None None 4w2p C NA 0 IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody C LAMA GLAMA lama glama Taylor, A.B., Garza, J.A. 1.77 X-RAY DIFFRACTION 0.203 0.165 False True IGHV1 None None None None None 6gk4 B NA 0 A protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 Human NBD1 of CFTR in complex with nanobodies D12 and T8 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.91 X-RAY DIFFRACTION 0.295 0.246 False True IGHV1 None None None None None 5f3j C c 0 A protein duffy receptor IMMUNE SYSTEM 12/02/15 Crystal structure of DBP in complex with inhibitory monoclonal antibody 2D10 PLASMODIUM VIVAX (STRAIN SALVADOR I); MUS MUSCULUS mus musculus plasmodium vivax (strain salvador i) Chen, E., Salinas, N.D., Tolia, N.H. 4.001 X-RAY DIFFRACTION 0.300 0.267 True True unknown unknown unknown None None None None None 3j8v G K 0 C protein NA l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H16.14J Fab HUMAN PAPILLOMAVIRUS TYPE 16; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 16 Guan, J., Hafenstein, S. 13.9 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV13 Kappa None None None None None 3rvt D C 0 IMMUNE SYSTEM 05/06/11 Structure of 4C1 Fab in P212121 space group MUS MUSCULUS mus musculus mus musculus Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W. 2.05 X-RAY DIFFRACTION 0.233 0.193 False True IGHV3 IGKV14 Kappa None None None None None 2x1o B NA 0 CONTRACTILE PROTEIN 01/03/10 Gelsolin Nanobody LAMA GLAMA lama glama Van den Abbeele, A., DeClercq, S., DeGanck, A., DeCorte, V., Van Loo, B., Srinivasan, V., Steyaert, J., Vandekerckhove, J., Gettemans, J. 1.34 X-RAY DIFFRACTION 0.24007 0.21135 False True IGHV1 None None None None None 6c6z C D 0 A protein spike protein IMMUNE SYSTEM 01/19/18 Crystal structure of potent neutralizing antibody CDC2-C2 in complex with MERS-CoV S1 RBD MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome-relatedcoronavirus Wang, N., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.228 0.191 False True IGHV1 IGKV2 Kappa None None None None None 6njn K J 0 B protein glutamate receptor 2 MEMBRANE PROTEIN 01/03/19 structure of a complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Gouaux, E., Zhao, Y. 6.5 ELECTRON MICROSCOPY False True IGHV2 IGKV10 Kappa None None None None None 3u79 NA G 0 IMMUNE SYSTEM 10/13/11 AL-103 Y32F Y96F HOMO SAPIENS homo sapiens DiCostanzo, A.C., Thompson, J.R., Ramirez-Alvarado, M. 1.62 X-RAY DIFFRACTION 0.223 0.169 False True IGKV1 Kappa None None None None None 7tes M N 0 D | C protein | protein NA | NA glutamate receptor ionotropic, nmda 2b | glutamate receptor ionotropic, nmda 1 SIGNALING PROTEIN/IMMUNE SYSTEM 01/05/22 Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in Non-active1 conformation RATTUS NORVEGICUS; MUS MUSCULUS mus musculus mus musculus rattus norvegicus | rattus norvegicus Tajima, N., Furukawa, H. 4.7 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV3 Kappa None None None None None 7my3 H NA 0 C protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/20/21 CryoEM structure of neutralizing nanobody Nb12 in complex with SARS-CoV2 spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus severe acute respiratory syndrome coronavirus2 Xu, K., Kwong, P.D. 2.9 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 4od1 H L 0 IMMUNE SYSTEM 01/09/14 Crystal structure of human Fab CAP256-VRC26.03, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 2.69 X-RAY DIFFRACTION 0.244 0.203 False True IGHV3 IGLV1 Lambda None None None None None 1mvf A NA 0 E peptide pemi-like protein 1 IMMUNE SYSTEM 09/25/02 MazE addiction antidote CAMELUS DROMEDARIUS; ESCHERICHIA COLI camelus dromedarius escherichia coli Loris, R., Marianovsky, I., Lah, J., Laeremans, T., Engelberg-Kulka, H., Glaser, G., Muyldermans, S., Wyns, L. 1.65 X-RAY DIFFRACTION 0.249 0.218 False True IGHV1 None None None None None 5ig7 J K 0 L peptide peptide pro-leu-gln-pro-gln-gln-pro-phe-pro IMMUNE SYSTEM 02/27/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPQQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.97 X-RAY DIFFRACTION 0.236 0.190 False True IGHV3 IGLV4 Lambda None None None None None 6u14 B NA 0 IMMUNE SYSTEM 08/15/19 VHH R303 C33A/C102A in complex withthe LRR domain of InlB CAMELUS DROMEDARIUS camelus dromedarius Mendoza, M.N., Jian, M., Toride King, M., Brooks, C.L. 1.3 X-RAY DIFFRACTION 0.179 0.159 False True IGHV1 None None None None None 6nf2 J K 0 A protein envelope glycoprotein gp120 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True IGHV4 unknown unknown None None None None None 4kph H L 0 immune system 05/13/13 Structure of the Fab fragment of N62, a protective monoclonal antibody to the nonreducing end of Francisella tularensis O-antigen MUS MUSCULUS mus musculus mus musculus Lu, Z., Rynkiewicz, M.J., Yang, C.-Y., Madico, G., Perkins, H.M., Wang, Q., Costello, C.E., Zaia, J., Seaton, B.A., Sharon, J. 2.59 X-RAY DIFFRACTION 0.268 0.222 False False IGHV3 IGKV4 Kappa None None None None None 1d5i H L 0 IMMUNE SYSTEM 10/07/99 UNLIGANDED GERMLINE PRECURSOR OF AN OXY-COPE CATALYTIC ANTIBODY MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C. 2.0 X-RAY DIFFRACTION 0.263 0.216 False True IGHV1 IGKV14 Kappa None None None None None 6u6u H L 0 R protein interleukin-1 receptor-like 2 CYTOKINE 08/30/19 IL36R extracellular domain in complex with BI655130 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Larson, E.T., Farrow, N.A. 2.31 X-RAY DIFFRACTION 0.202 0.179 False True IGHV1 IGKV3 Kappa None None None None None 7v3j I M 0 O | Q | P protein | protein | protein NA | NA | NA envelope protein e | envelope protein e | envelope protein e IMMUNE SYSTEM/VIRUS 08/10/21 DENV2:F(ab')2-local HOMO SAPIENS; DENGUE VIRUS TYPE 2 (STRAIN THAILAND/NGS-C/1944) homo sapiens homo sapiens dengue virus type 2 (strain thailand/ngs-c/1944) | dengue virus type 2 (strain thailand/ngs-c/1944) | dengue virus type 2 (strain thailand/ngs-c/1944) Shu, B., Zhang, S., Victor, A.K., Ng, T.S., Lok, S.M. 4.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6uye I L 0 C protein sgp VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 EBOV GPdMuc Makona bound to rEBOV-548 Fab EBOLA VIRUS; HOMO SAPIENS homo sapiens homo sapiens ebola virus Murin, C.D., Ward, A.B. 3.96 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6df2 B A 0 C peptide leu-ptr-leu IMMUNE SYSTEM 05/13/18 Improved anti-phosphotyrosine antibody 4G10-S5-4D5 Fab complexed with phosphotyrosine peptide SYNTHETIC CONSTRUCT synthetic construct synthetic construct synthetic construct Mou, K., Leung, K., Wells, J.A. 2.6 X-RAY DIFFRACTION 0.230 0.177 False True IGHV3 IGKV1 Kappa 5.720000000000001e-08 -9.880679659658352 Unknown TBD 7r8u H L 0 A | B protein | protein NA | NA unknown | unknown SIGNALING PROTEIN/IMMUNE SYSTEM 06/27/21 LOX-1 - Structural and Functional Studies of a Receptor Implicated in Atherosclerosis HOMO SAPIENS Oganesyan, V., van Dyk, N. 1.901 X-RAY DIFFRACTION 0.218 0.186 False False IGHV1 IGLV1 Lambda None None None None None 3se8 H L 0 G protein hiv-1 clade ae strain 93th057 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 06/10/11 Crystal structure of broadly and potently neutralizing antibody VRC03 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwong, P.D., Zhou, T. 1.895 X-RAY DIFFRACTION 0.233 0.187 False True IGHV1 IGKV3 Kappa None None None None None 2rcj F G 0 IMMUNE SYSTEM 09/20/07 Solution structure of human Immunoglobulin M HOMO SAPIENS homo sapiens homo sapiens Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. NOT SOLUTION SCATTERING False False IGHV3 IGLV1 Lambda None None None None None 7zxu H L 0 E protein NA spike protein s1 VIRAL PROTEIN 05/23/22 SARS-CoV-2 Omicron BA.4/5 RBD in complex with Beta-27 Fab and C1 nanobody Homo sapiens; Lama glama; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Huo, J., Zhou, D., Ren, J., Stuart, D.I. 1.89 X-RAY DIFFRACTION 0.209 0.181 False True IGHV3 IGKV3 Kappa None None None None None 5m2j D NA 0 A protein tumor necrosis factor CYTOKINE 10/13/16 Complex between human TNF alpha and Llama VHH2 HOMO SAPIENS homo sapiens homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 1.9 X-RAY DIFFRACTION 0.196 0.158 False True IGHV3 1.3000000000000002e-10 -13.48699434919035 SPR TBD 6pef D E 0 F peptide NA hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/20/19 Vaccine-elicited NHP FP-targeting antibody DF2F-a.01 in complex with HIV fusion peptide (residue 512-519) MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Xu, K., Liu, K., Wang, Y., Kwong, P.D. 2.004 X-RAY DIFFRACTION 0.214 0.183 False True IGHV4 IGLV1 Lambda None None None None None 2qtj B M 6 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7tly A B 0 I protein NA spike glycoprotein VIRUS/IMMUNE SYSTEM 01/19/22 SARS-CoV-2 S B.1.1.529 Omicron variant (RBD + S309 Local Refinement) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5f6j B A 0 G protein envelope glycoprotein gp120 of hiv-1 clade c Viral Protein/Immue System 12/06/15 Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Fera, D., Harrison, S.C. 6.63 X-RAY DIFFRACTION 0.305 0.256 False True IGHV3 IGLV2 Lambda None None None None None 3qg7 H L 0 IMMUNE SYSTEM 01/24/11 Structural Basis for Ligand Recognition and Discrimination of a Quorum Quenching Antibody MUS MUSCULUS mus musculus mus musculus Kirchdoerfer, R.K., Kaufmann, G.F., Janda, J.D., Wilson, I.A. 2.78 X-RAY DIFFRACTION 0.240 0.195 False True IGHV3 IGKV1 Kappa None None None None None 5bvp H L 0 I protein interleukin-1 beta IMMUNE SYSTEM 06/05/15 The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta HOMO SAPIENS homo sapiens homo sapiens homo sapiens Rondeau, J.M. 2.2 X-RAY DIFFRACTION 0.231 0.188 False True IGHV3 IGKV6 Kappa 3.05e-11 -14.345981790181611 SPR TBD 6edu N O 0 E | H protein | protein NA | NA envelope glycoprotein gp160 | t-cell surface glycoprotein cd4 IMMUNE SYSTEM 08/11/18 B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | homo sapiens Barnes, C.O., Bjorkman, P.J. 4.06 ELECTRON MICROSCOPY False True IGHV1 IGLV1 Lambda None None None None None 1lmk C c 0 IMMUNOGLOBULIN 08/29/94 THE STRUCTURE OF A BIVALENT DIABODY MUS MUSCULUS mus musculus Williams, R.L. 2.6 X-RAY DIFFRACTION unknown 0.200 True True unknown unknown unknown None None None None None 5k9q S T 0 N | M | O protein | protein | protein NA | NA | NA hemagglutinin ha2 | hemagglutinin ha1 | hemagglutinin ha1 IMMUNE SYSTEM 06/01/16 Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin INFLUENZA A VIRUS; INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus | influenza a virus Joyce, M.G., Thomas, P.V., Wheatley, A.K., McDermott, A.B., Mascola, J.R., Kwong, P.D. 2.503 X-RAY DIFFRACTION 0.218 0.182 False True IGHV1 IGKV1 Kappa None None None None None 4kjq C D 0 A protein h(+)/cl(-) exchange transporter clca tranport protein, membrane protein 05/03/13 Structure of the CLC-ec1 deltaNC construct in 100mM fluoride MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C 2.875 X-RAY DIFFRACTION 0.263 0.220 False True IGHV4 IGKV4 Kappa None None None None None 6a96 K NA 0 D protein gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 07/11/18 Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Liu, S., Xu, L., Guan, F., Liu, Y.T., Cui, Y., Zhang, Q., Bi, G.Q., Zhou, Z.H., Zhang, X., Ye, S. 3.51 ELECTRON MICROSCOPY False True IGHV1 None None None None None 6zjg H L 0 C peptide NA unknown IMMUNE SYSTEM 06/29/20 Crystal structure of ACPA E4 in complex with CII-C-48-CIT HOMO SAPIENS Ge, C., Holmdahl, R. 2.45 X-RAY DIFFRACTION 0.265 0.223 False False IGHV4 IGLV1 Lambda None None None None None 3c5s B A 0 IMMUNE SYSTEM 02/01/08 Crystal Structure of monoclonal Fab F22-4 specific for Shigella flexneri 2a O-Ag MUS MUSCULUS mus musculus mus musculus Saul, F.A., Vulliez-le-Normand, B., Bentley, G.A. 2.0 X-RAY DIFFRACTION 0.260 0.199 False False IGHV6 IGKV2 Kappa None None None None None 3pp3 I K 0 IMMUNE SYSTEM 11/24/10 Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for the type I / type II distinction of anti- CD20 antibodies MUS MUSCULUS mus musculus mus musculus Hopfner, K.-P., Lammens, A. 2.508 X-RAY DIFFRACTION 0.269 0.206 False True IGHV1 IGKV2D Kappa None None None None None 6kr0 B b 0 NA NA NA NA IMMUNE SYSTEM 08/20/19 Crystal structure of HL homo-diabody HOMO SAPIENS homo sapiens Tanaka, Y. 2.3 X-RAY DIFFRACTION 0.226 0.202 True True unknown unknown unknown None None None None None 6e4z H L 0 P peptide proprotein convertase subtilisin/kexin type 9 IMMUNE SYSTEM 04/10/19 Anti-PCSK9 fab 6E2 bound to the modified N-terminal peptide from PCSK9 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Ultsch, M.H., Kirchhofer, D.K. 2.202 X-RAY DIFFRACTION 0.236 0.195 False True IGHV6 IGKV2 Kappa None None None None None 6vrq H L 0 NA NA NA NA IMMUNE SYSTEM 02/08/20 Crystal structure of gl12A21 Fab in complex with anti-idiotypic iv12 Fab MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Aljedani, S.S., Weidle, C., Pancera, M. 2.57 X-RAY DIFFRACTION 0.241 0.189 False True IGHV1 IGKV6 Kappa None None None None None 6wwz S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/09/20 Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein RATTUS NORVEGICUS; HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | rattus norvegicus Wasilko, D.J., Johnson, Z.L., Ammirati, M., Han, S., Wu, H. 3.34 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1oau I NA 0 IMMUNE SYSTEM 01/21/03 Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) RATTUS RATTUS rattus rattus James, L.C., Roversi, P., Tawfik, D. 1.8 X-RAY DIFFRACTION 0.264 0.226 False True IGHV1 2.00e-08 Other 20 12610298 7mfu C NA 0 A protein NA spike protein s1 VIRAL PROTEIN 04/11/21 Crystal structure of synthetic nanobody complexes with SARS-CoV-2 receptor binding domain SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Ahmad, J., Natarajan, K., Boyd, L.F., Margulies, D.H. 1.7 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 NA NA None None None None None 4al8 H L 0 C protein envelope protein IMMUNE SYSTEM 03/02/12 Structure of Dengue virus DIII in complex with Fab 2H12 DENGUE VIRUS; HOMO SAPIENS homo sapiens homo sapiens dengue virus Midgley, C.M., Flanagan, A., Mongkolsapaya, J., Grimes, J.M., Screaton, G.R. 1.66 X-RAY DIFFRACTION 0.1975 0.1699 False False IGHV1 IGKV6 Kappa 4.5000000000000005e-10 -12.751299583055715 ELISA TBD 5eii A B 0 I protein histone chaperone asf1 IMMUNE SYSTEM 10/29/15 Structural determination of an protein complex of a Fab with increased solubility HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Bailey, L.J., Kossiakoff, A.A., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS) 2.44 X-RAY DIFFRACTION 0.233 0.185 False True IGHV3 IGKV1 Kappa None None None None None 4r2g D C 0 O protein surface protein gp160 IMMUNE SYSTEM 08/11/14 Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (JRCSF ISOLATE); HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 (jrcsfisolate) Garces, F., Wilson, I.A. 3.283 X-RAY DIFFRACTION 0.263 0.207 False True IGHV4 IGLV3 Lambda 3.4e-08 -10.188885744060974 ITC TBD 5tpn H L 0 A protein fusion glycoprotein f0,fibritin IMMUNE SYSTEM 10/20/16 Crystal structure of RSV F in complex with human antibody hRSV90 HUMAN RESPIRATORY SYNCYTIAL VIRUS A; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a,enterobacteria phage ox2 Mousa, J.J., Crowe, J.E. 3.141 X-RAY DIFFRACTION 0.262 0.224 False False IGHV3 IGKV3 Kappa None None None None None 6ute I J 0 VIRAL PROTEIN 10/29/19 Crystal structure of Z032 Fab in complex with WNV EDIII HOMO SAPIENS; WEST NILE VIRUS homo sapiens homo sapiens Esswein, S.R., Gristick, H.B., Keeffe, J.R., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 5dlm I M 0 Y peptide matrix protein 2 IMMUNE SYSTEM 09/07/15 Complex of Influenza M2e and Antibody MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus influenza a virus Cho, K.J., Schepens, B., Moonens, K., Deng, L., Fiers, W., Remaut, H., Saelens, X. 2.2 X-RAY DIFFRACTION 0.240 0.187 False False IGHV5 IGKV1 Kappa None None None None None 6chb D E 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 02/22/18 Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 6.801 X-RAY DIFFRACTION 0.417 0.318 False True IGHV1 IGLV2 Lambda None None None None None 6um6 G H 0 E protein ch848 10.17dt gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunder, K.O., Haynes, B.F. 4.3 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 5kov W w 0 S protein capsid polyprotein vp90 VIRAL PROTEIN 07/01/16 Crystal structure of the human astrovirus 2 capsid protein spike in complex with a single chain variable fragment of an astrovirus neutralizing antibody at 3.24-A resolution HUMAN ASTROVIRUS-2; MUS MUSCULUS mus musculus human astrovirus-2 Bogdanoff, W.A., DuBois, R.M. 3.245 X-RAY DIFFRACTION 0.288 0.241 True True unknown unknown unknown 1.8700000000000004e-09 -11.907338499719083 SPR TBD 4y8d D NA 0 B protein cyclin-g-associated kinase TRANSFERASE 02/16/15 Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Chaikuad, A., Heroven, C., Nowak, R., De Jonghe, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC) 2.1 X-RAY DIFFRACTION 0.232 0.192 False False IGHV1 8.9e-09 -10.982997099581803 Unknown TBD 2fl5 B A 0 B Hapten RBF RIBOFLAVIN IMMUNE SYSTEM 01/05/06 Cofactor-containing antibodies: Crystal structure of the original yellow antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Zhu, X., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.290 0.240 False False IGHV3 IGLV3 Lambda 1.8000000000000002e-09 -11.929942798416155 Unknown TBD 5a7x N M 0 A protein hiv-1 yu2 gp120 VIRAL PROTEIN 07/10/15 negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 17.0 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6y1r A NA 0 NA NA NA NA IMMUNE SYSTEM 02/13/20 Nb22-LBT LAMA GLAMA lama glama Pompidor, G., Zimmermann, S., Loew, C., Schneider, T. 1.85 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 NA NA None None None None None 2kh2 B b 41 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 4j6r H L 0 G protein envelope glycoprotein gp160 viral protein/immune system 02/11/13 Crystal structure of broadly and potently neutralizing antibody VRC23 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong P.D. 1.64 X-RAY DIFFRACTION 0.198 0.164 False True unknown IGKV3 Kappa None None None None None 1hil D C 0 IMMUNOGLOBULIN 07/08/92 STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIGEN-ANTIBODY RECOGNITION MUS MUSCULUS mus musculus mus musculus Rini, J.M., Wilson, I.A. 2.0 X-RAY DIFFRACTION unknown 0.195 False False IGHV5 IGKV8 Kappa None None None None None 7sob N O 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3hzk B A 0 B carbohydrate KDA polysaccharide IMMUNE SYSTEM 06/23/09 Crystal structure of S73-2 antibody in complex with antigen Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Muller-Loennies, S., Borisova, S.N., Brade, L., Kosma, P., Hirama, T., MacKenzie, C.R., Brade, H., Evans, S.V. 2.15 X-RAY DIFFRACTION 0.260 0.214 False False IGHV7 IGKV8 Kappa 2e-07 -9.139030233551999 Unknown TBD 4jpi H L 0 IMMUNE SYSTEM 03/19/13 Crystal structure of a putative VRC01 germline precursor Fab HOMO SAPIENS Julien, J.-P., Diwanji, D.C., Jardine, J., Schief, W.R., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.214 0.175 False True IGHV1 IGKV3 Kappa None None None None None 6xzu A NA 0 B protein NA complement c3 IMMUNE SYSTEM 02/05/20 Complex of C-terminal domain of murine complement C3b with the hC3Nb3 nanobody LAMA GLAMA; MUS MUSCULUS lama glama mus musculus Andersen, G.R., Pedersen, H. 1.5 X-RAY DIFFRACTION 0.200 0.166 False True IGHV1 NA NA None None None None None 5f97 G NA 0 C protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain A730 in complex with blood group A type 1 hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.62 X-RAY DIFFRACTION 0.237 0.188 False True IGHV1 None None None None None 7v0v A NA 7 NA NA NA NA IMMUNE SYSTEM 05/11/22 GFP Nanobody NMR Structure SYNTHETIC CONSTRUCT synthetic construct Mueller, G.A. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 3c2a I M 0 Q peptide envelope glycoprotein IMMUNE SYSTEM 01/24/08 Antibody Fab fragment 447-52D in complex with UG1033 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Dhillon, A.K., Stanfield, R.L., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.298 0.240 False False IGHV3 IGLV1 Lambda None None None None None 4hh9 B A 0 IMMUNE SYSTEM 10/09/12 Anti-Human Cytomegalovirus (HCMV) Fab KE5 HOMO SAPIENS homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Pfoh, R., Schrader, J.W., Pai, E.F. 1.7 X-RAY DIFFRACTION 0.224 0.217 False False IGHV3 IGKV3 Kappa None None None None None 7kc9 C NA 0 B | A protein | protein NA | NA ricin chain b | ricin chain a TOXIN 10/05/20 Ricin bound to VHH antibody V5G1 VICUGNA PACOS; RICINUS COMMUNIS vicugna pacos ricinus communis | ricinus communis Rudolph, M.J. 2.301 X-RAY DIFFRACTION 0.238 0.187 False True IGHV1 NA NA None None None None None 4laj L NA 0 A | D protein | peptide NA | NA hiv-1 yu2 gp120 envelope glycoprotein | cd4-mimetic miniprotein m48u1 VIRAL PROTEIN/INHIBITOR 06/20/13 Crystal structure of HIV-1 YU2 envelope gp120 glycoprotein in complex with CD4-mimetic miniprotein, M48U1, and llama single-domain, broadly neutralizing, co-receptor binding site antibody, JM4 HUMAN IMMUNODEFICIENCY VIRUS 1; LLAMA GLAMA; SYNTHETIC CONSTRUCT lama glama human immunodeficiency virus 1 | Acharya, P., Luongo, T.S., Kwong, P.D. 2.14 X-RAY DIFFRACTION 0.227 0.185 False True IGHV1 None None None None None 7e5r T V 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 02/20/21 SARS-CoV-2 S trimer with three-antibody cocktail complex HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sun, Y., Wang, L., Wang, N., Feng, R., Wang, X. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6nz7 H L 0 B | A protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM 02/13/19 Crystal structure of broadly neutralizing Influenza A antibody 429 B01 in complex with Hemagglutinin Hong Kong 1968 INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Zhou, T., Kwong, P.D. 2.95 X-RAY DIFFRACTION 0.267 0.224 False True IGHV3 IGKV1 Kappa None None None None None 4xwo U V 0 S protein sec22 HYDROLASE/TRANSPORT PROTEIN 01/29/15 Structure of Get3 bound to the transmembrane domain of Sec22 HOMO SAPIENS, SYNTHETIC CONSTRUCT; SACCHAROMYCES CEREVISIAE (ATCC 204508 / S288C); SACCHAROMYCES CEREVISIAE homo sapiens, synthetic construct homo sapiens, synthetic construct saccharomyces cerevisiae (atcc 204508 / s288c) Mateja, A., Paduch, M., Chang, H.-Y., Szydlowska, A., Kossiakoff, A.A., Hegde, R.S., Keenan, R.J. 2.75 X-RAY DIFFRACTION 0.247 0.196 False True IGHV3 IGKV1 Kappa None None None None None 4ma1 H L 0 IMMUNE SYSTEM 08/15/13 Unliganded 3 crystal structure of S25-26 Fab MUS MUSCULUS mus musculus mus musculus Haji-Ghassemi, O., Evans, S.V. 2.32 X-RAY DIFFRACTION 0.260 0.229 False False IGHV2 IGKV1 Kappa None None None None None 4hg4 R S 0 E | b protein | protein NA | NA hemagglutinin ha2 | unknown VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 4kxz J I 0 B protein transforming growth factor beta-2 immune system 05/28/13 crystal structure of tgfb2 in complex with GC2008. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mathieu, M., Moulin, A.G., Wei, R. 2.83 X-RAY DIFFRACTION 0.222 0.183 False True IGHV1 IGKV3 Kappa 3.0000000000000004e-09 -11.627286953008985 SPR TBD 7r88 C D 0 B | A protein | protein NA | NA atp-binding cassette sub-family g member 8 | atp-binding cassette sub-family g member 5 LIPID TRANSPORT/IMMUNE SYSTEM 06/26/21 The structure of human ABCG5-I529W/ABCG8-WT HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Sun, Y., Li, X., Long, T. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV7 IGKV9 Kappa None None None None None 1e4x I M 0 Q peptide cyclic peptide IMMUNE SYSTEM 07/12/00 crossreactive binding of a circularized peptide to an anti-TGFalpha antibody Fab-fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Hahn, M., Winkler, D., Misselwitz, R., Wessner, H., Welfle, K., Zahn, G., Schneider-Mergener, J., Hoehne, W. 1.9 X-RAY DIFFRACTION 0.311 0.245 False False IGHV1 IGKV10 Kappa None None None None None 7cai G F 0 B | C protein | protein NA | NA spike glycoprotein | spike glycoprotein VIRAL PROTEIN 06/08/20 SARS-CoV-2 S trimer with two RBDs in the open state and complexed with two H014 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 | severe acute respiratory syndrome coronavirus2 Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X. 3.49 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 6um6 C D 0 A protein ch848 10.17dt gp120 VIRAL PROTEIN/immune system 10/09/19 Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Henderson, R.C., Saunder, K.O., Haynes, B.F. 4.3 ELECTRON MICROSCOPY False True IGHV1 IGLV2 Lambda None None None None None 7cqd H L 0 A protein NA putative zinc metalloprotease aq_1964,pa14 from podoplanin,putative zinc metalloprotease aq_1964 HYDROLASE/IMMUNE SYSTEM 08/10/20 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 235 and 236 RATTUS NORVEGICUS; AQUIFEX AEOLICUS VF5; HOMO SAPIENS rattus norvegicus rattus norvegicus aquifex aeolicus vf5, homo sapiens Tamura-Sakaguchi, R., Aruga, R., Nogi, T. 3.2 X-RAY DIFFRACTION 0.286 0.265 False True IGHV5 IGLV3 Lambda None None None None None 6h72 C NA 0 A protein NA capsid protein vp1 VIRAL PROTEIN 07/30/18 GI.1 human norovirus protruding domain in complex with Nano-94 and 2-fucosyllactose (2FL) NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Hansman, G.S. 2.3 X-RAY DIFFRACTION 0.202 0.172 False True IGHV1 NA NA None None None None None 6b20 E NA 0 B | D protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(t) subunit gamma-t1 SIGNALING PROTEIN 09/19/17 Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator BOS TAURUS; LAMA GLAMA lama glama bos taurus | bos taurus Gulati, S., Kiser, P.D., Palczewski, K. 2.34 X-RAY DIFFRACTION 0.249 0.200 False True IGHV1 NA NA None None None None None 6phh A B 0 IMMUNE SYSTEM 06/25/19 Unliganded human transmission blocking antibody 2544 HOMO SAPIENS homo sapiens homo sapiens McLeod, B.R., Julien, J.P. 2.4 X-RAY DIFFRACTION 0.249 0.218 False True IGHV3 IGKV2 Kappa None None None None None 6k65 H L 0 A protein immunoglobulin g-binding protein a STRUCTURAL PROTEIN 06/01/19 Application of anti-helix antibodies in protein structure determination (9014-1P4B) STAPHYLOCOCCUS AUREUS (STRAIN NCTC 8325); MUS MUSCULUS mus musculus mus musculus staphylococcus aureus (strain nctc 8325) Lee, J.O., Jin, M.S., Kim, J.W., Kim, S., Lee, H., Cho, G.Y. 1.65 X-RAY DIFFRACTION 0.192 0.170 False True IGHV2 IGLV1 Lambda None None None None None 3piq H L 0 IMMUNE SYSTEM 11/07/10 Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1 HOMO SAPIENS homo sapiens homo sapiens Changela, A., Gorny, M.K., Zolla-Pazner, S., Kwong, P.D. 3.325 X-RAY DIFFRACTION 0.299 0.236 False True IGHV3 IGLV3 Lambda None None None None None 5i19 H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV1-39 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.8 X-RAY DIFFRACTION 0.315 0.239 False True IGHV3 IGKV1 Kappa None None None None None 6b9z B A 0 C | E protein | protein NA | NA immunoglobulin g binding protein a | protein l IMMUNE SYSTEM 10/11/17 Trastuzumab Fab v3 MUS MUSCULUS; HOMO SAPIENS; FINEGOLDIA MAGNA; STAPHYLOCOCCUS AUREUS mus musculus, homo sapiens mus musculus, homo sapiens staphylococcus aureus | finegoldia magna Bzymek, K.P., King, J.D., Williams, J.C. 1.82 X-RAY DIFFRACTION 0.189 0.165 False True IGHV3 IGKV1 Kappa None None None None None 7kbo A a 0 NA NA NA NA PROTEIN BINDING 10/02/20 Reverse Transcriptase Diabody with S82bC, R83T Mutations Crystallized in C2 HOMO SAPIENS homo sapiens Chesterman, C., Arnold, E. 2.2 X-RAY DIFFRACTION 0.225 0.178 True True unknown unknown unknown None None None None None 7dd2 A B 0 C protein NA sars-cov2-s protein VIRAL PROTEIN 10/27/20 S-3C1-F2 structure, two RBDs are up and one RBD is down, the two up RBD bind with a 3C1 fab. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 5.6 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 5cgy H L 0 IMMUNE SYSTEM 07/09/15 Fab fragment of Chikungunya virus neutralizing human monoclonal antibody 4J21 HOMO SAPIENS homo sapiens homo sapiens Long, F., Crowe, J.E., Rossmann, M.G. 2.07 X-RAY DIFFRACTION 0.216 0.168 False False IGHV7 IGLV1 Lambda None None None None None 3pnw H G 0 I protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 6k2i A NA 2 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 6ous U V 0 J | I protein | protein NA | NA fusion glycoprotein f1 fused with fibritin trimerizationdomain | fusion glycoprotein f2 VIRAL PROTEIN/Immune system 05/05/19 Structure of fusion glycoprotein from human respiratory syncytial virus HUMAN RESPIRATORY SYNCYTIAL VIRUS A2; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a2, humanimmunodeficiency virus 1 | human respiratory syncytial virus a2 Su, H.P. 3.4 X-RAY DIFFRACTION 0.275 0.245 False True IGHV3 IGKV1 Kappa None None None None None 5u64 B NA 0 IMMUNE SYSTEM 12/07/16 Camel nanobody VHH-28 CAMELUS DROMEDARIUS camelus dromedarius Stanfield, R.L., Wilson, I.A. 1.153 X-RAY DIFFRACTION 0.170 0.145 False True IGHV1 None None None None None 3qhz H L 0 IMMUNE SYSTEM 01/26/11 Crystal Structure of human anti-influenza Fab 2D1 HOMO SAPIENS homo sapiens homo sapiens Ekiert, D.C., Wilson, I.A. 1.55 X-RAY DIFFRACTION 0.206 0.180 False True IGHV2 IGLV1 Lambda None None None None None 6u8d H L 0 A nucleic-acid jiiiabc rna (68-mer) RNA/Immune System 09/04/19 Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV2 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepacivirus c Koirala, D., Lewicka, A., Koldobskaya, Y., Huang, H., Piccirilli, J.A. 1.807 X-RAY DIFFRACTION 0.209 0.174 False True IGHV3 IGKV1 Kappa None None None None None 1adq H L 0 A protein igg4 rea fc COMPLEX (IMMUNOGLOBULIN/AUTOANTIGEN) 02/18/97 CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC HOMO SAPIENS homo sapiens homo sapiens homo sapiens Corper, A.L., Taussig, M.J., Sutton, B.J. 3.15 X-RAY DIFFRACTION 0.289 0.225 False False IGHV3 IGLV3 Lambda None None None None None 6mpg X Y 0 D protein envelope glycoprotein gp41 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS macaca mulatta macaca mulatta human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False True IGHV3 IGKV4 Kappa None None None None None 5jq6 H L 0 A protein clumping factor a IMMUNE SYSTEM 05/04/16 Crystal structure of ClfA in complex with the Fab fragment of Tefibazumab MUS MUSCULUS, HOMO SAPIENS; STAPHYLOCOCCUS AUREUS mus musculus, homo sapiens mus musculus, homo sapiens staphylococcus aureus Ganesh, V.K. 2.4 X-RAY DIFFRACTION 0.259 0.208 False True IGHV2 IGKV8 Kappa 7.900000000000001e-10 -12.41785844031504 SPR TBD 1uwx M K 0 Q peptide class 1 outer membrane protein variable region 2 IMMUNE SYSTEM 02/12/04 P1.2 serosubtype antigen derived from N. meningitidis PorA in complex with Fab fragment STREPTOCOCCUS SP.; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus neisseria meningitidis Tzitzilonis, C., Prince, S.M., Collins, R.F., Maiden, M.C.J., Feavers, I.M., Derrick, J.P. 2.2 X-RAY DIFFRACTION 0.265 0.223 False False IGHV9 IGKV12 Kappa 1.60e-06 -7.9 SPR 16470851 4xpt H L 0 protein transport/inhibitor 01/17/15 X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2 deletion of 162-201 in complex with substrate analogue 3,4 dichlorophen ethylamine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus Aravind, P., Wang, K., Gouaux, E. 3.36 X-RAY DIFFRACTION 0.273 0.232 False True IGHV5 IGKV4 Kappa None None None None None 6ikm P p 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 3qny B A 0 IMMUNE SYSTEM 02/09/11 Monoclinic form of human IgA1 Fab fragment, sharing same Fv as IgG HOMO SAPIENS homo sapiens homo sapiens Trajtenberg, F., Correa, A., Buschiazzo, A. 2.3 X-RAY DIFFRACTION 0.218 0.187 False False IGHV3 IGKV2 Kappa None None None None None 4qt5 B A 0 IMMUNE SYSTEM 07/07/14 Crystal Structure of 3BD10: A Monoclonal Antibody against the TSH Receptor MUS MUSCULUS mus musculus mus musculus Hubbard, P.A., Chen, C.R., McLachlan, S.M., Rapoport, B., Murali, R. 2.5 X-RAY DIFFRACTION 0.279 0.235 False True IGHV1 IGKV1 Kappa None None None None None 1mim H L 0 IMMUNOGLOBULIN 12/04/95 IGG FAB FRAGMENT (CD25-BINDING) HOMO SAPIENS homo sapiens homo sapiens Mikol, V. 2.6 X-RAY DIFFRACTION unknown 0.196 False True IGHV1 IGKV4 Kappa None None None None None 6oz4 H L 0 G protein NA envelope glycoprotein gp160 IMMUNE SYSTEM 05/15/19 Crystal structure of broadly neutralizing antibody N49P6 Fab in complex with HIV-1 BG505 SOSIP.664 Env trimer ectodomain. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 4.05 X-RAY DIFFRACTION 0.315 0.255 False True unknown IGLV2 Lambda None None None None None 7cu5 B b 0 E protein NA programmed cell death protein 1 IMMUNE SYSTEM 08/21/20 N-Glycosylation of PD-1 and glycosylation dependent binding of PD-1 specific monoclonal antibody camrelizumab HOMO SAPIENS homo sapiens homo sapiens Liu, K.F., Tan, S.G., Jin, W.J., Guan, J.W., Wang, W.L., Sun, H., Qi, J.X., Yan, J.H., Chai, Y., Wang, Z.F., Chu, X.D., Gao, G.F. 2.81 X-RAY DIFFRACTION 0.252 0.212 True True unknown unknown unknown None None None None None 1t2j A NA 0 IMMUNE SYSTEM 04/21/04 Crystal structure of a Human VH domain HOMO SAPIENS homo sapiens Gaur, R.K., Fischer, R., Hoffmann, K.M.V. 1.5 X-RAY DIFFRACTION 0.197 0.158 False True IGHV3 None None None None None 4ej1 D NA 0 A protein dihydrofolate reductase Oxidoreductase/Immune system 04/06/12 Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Oyen, D., Srinivasan, V. 1.75 X-RAY DIFFRACTION 0.224 0.186 False True IGHV1 None None None None None 5bk3 A B 0 B carbohydrate NAG polysaccharide IMMUNE SYSTEM 09/12/17 Crystal structure of the neutralizing anti-circumsporozoite protein 580 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 2.8 X-RAY DIFFRACTION 0.231 0.190 False True IGHV3 IGKV4 Kappa None None None None None 7s0d O P 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/30/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-014 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7rga B NA 0 B Hapten MTX METHOTREXATE IMMUNE SYSTEM 07/14/21 Crystal structure of nanoCLAMP3:VHH in complex with MTX NANOA nanoa nanoa Guo, Z., Alexandrov, K. 2.9 X-RAY DIFFRACTION 0.242 0.195 False True IGHV1 NA NA None None None None None 7o06 B NA 0 D protein NA centrosomal protein of 164 kda STRUCTURAL PROTEIN 03/25/21 Crystal structure of the N-terminal domain of CEP164(1-109) bound to camelid nanobody 10Z CAMELIDAE MIXED LIBRARY; HOMO SAPIENS camelidae mixed library homo sapiens e Silva, I.R., van Breugel, M. 1.6 X-RAY DIFFRACTION 0.211 0.180 False True IGHV1 NA NA None None None None None 6mpg M N 0 C protein envelope glycoprotein gp120 VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 3.2 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 5mu0 E F 0 S peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 6dwc B A 0 IMMUNE SYSTEM 06/26/18 Structure of the apo 4497 antibody Fab fragment HOMO SAPIENS homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.27 X-RAY DIFFRACTION 0.217 0.184 False True IGHV3 IGKV4 Kappa None None None None None 7chp H L 0 E protein NA spike protein s1 VIRAL PROTEIN 07/06/20 Crystal structure of SARS-CoV-2 antibody P5A-3C8 with RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Ge, J., Wang, R., Zhang, Q. 2.357 X-RAY DIFFRACTION 0.220 0.193 False True IGHV3 IGKV1 Kappa None None None None None 6vtu H L 0 A carbohydrate MAN ALPHA-D-MANNOSE IMMUNE SYSTEM 02/13/20 DH717.1 Fab monomer in complex with man9 glycan HOMO SAPIENS homo sapiens homo sapiens Fera, D., Bronkema, N. 2.61 X-RAY DIFFRACTION 0.224 0.191 False True IGHV4 IGLV2 Lambda None None None None None 6yor B C 0 A protein rbd VIRAL PROTEIN 04/15/20 Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab SEVERE ACUTE RESPIRATORY SYNDROME-RELATED CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Huo, J., Zhao, Y., Ren, J., Zhou, D., Duyvesteyn, H.M.E., Carrique, L., Malinauskas, T., Ruza, R.R., Shah, P.N.M., Fry, E.E., Owens, R., Stuart, D.I. 3.9 ELECTRON MICROSCOPY False True IGHV5 IGKV4 Kappa None None None None None 6vor A B 0 NA NA NA NA IMMUNE SYSTEM 01/31/20 Crystal structure of macaque anti-HIV-1 antibody RM20E1 MACACA MULATTA macaca mulatta macaca mulatta Yuan, M., Wilson, I.A. 1.85 X-RAY DIFFRACTION 0.252 0.224 False True IGHV5 IGKV2 Kappa None None None None None 5th9 I M 0 B protein matrix metalloproteinase-9,matrix metalloproteinase-9 hydrolase/hydrolase inhibitor 09/29/16 Structure determination of a potent, selective antibody inhibitor of human MMP9 (GS-5745 bound to MMP-9) ORYCTOLAGUS CUNICULUS; HOMO SAPIENS oryctolagus cuniculus oryctolagus cuniculus homo sapiens Appleby, T.C., Greenstein, A.E., Kwon, H.J. 2.999 X-RAY DIFFRACTION 0.257 0.218 False True IGHV2 IGKV6 Kappa None None None None None 6pyc A B 0 IMMUNE SYSTEM 07/29/19 Structure of kappa-on-heavy (KoH) antibody Fab bound to the cardiac hormone marinobufagenin MUS MUSCULUS mus musculus mus musculus Franklin, M.C., Macdonald, L.E., McWhirter, J., Murphy, A.J. 3.6 X-RAY DIFFRACTION 0.287 0.234 False True IGHV4 IGKV6 Kappa None None None None None 6oc3 A B 0 F protein hemagglutinin IMMUNE SYSTEM 03/21/19 Crystal structure of FluA-20 Fab in complex with the head domain of H1 (A/Solomon Islands/3/2006) HOMO SAPIENS; INFLUENZA A VIRUS (A/SOLOMON ISLANDS/3/2006(H1N1)) homo sapiens homo sapiens influenza a virus (a/solomonislands/3/2006(h1n1)) Wilson, I.A., Lang, S. 2.85 X-RAY DIFFRACTION 0.257 0.237 False True IGHV4 IGKV1 Kappa None None None None None 6zlr F G 0 D protein NA unknown VIRAL PROTEIN 07/01/20 Soaking competent crystal form of the SARS-CoV-2 Receptor Binding Domain (RBD):CR3022 complex. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS de Nicola, G.F., Nichols, C.E. 3.1 X-RAY DIFFRACTION 0.247 0.218 False False IGHV5 IGKV4 Kappa None None None None None 4xp4 H L 0 A protein dopamine transporter transport protein/inhibitor 01/16/15 X-ray structure of Drosophila dopamine transporter in complex with cocaine DROSOPHILA MELANOGASTER; MUS MUSCULUS mus musculus mus musculus drosophila melanogaster Aravind, P., Wang, K., Gouaux, E. 2.8 X-RAY DIFFRACTION 0.266 0.236 False True IGHV5 IGKV4 Kappa None None None None None 6lfw A a 0 a Hapten OMF 1,2,3-tris(chloranyl)-5-(3-chloranyl-4-methoxy-phenyl)benzene IMMUNE SYSTEM 12/03/19 Crystal structure of PCB4scFv(hN56D) in complex with PCB#126 MUS MUSCULUS mus musculus Nakamura, T., Yamagata, Y., Morioka, H. 1.41 X-RAY DIFFRACTION 0.156 0.126 True True unknown unknown unknown None None None None None 7jv2 H L 0 A protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 08/20/20 SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody Fab fragment (local refinement of the receptor-binding motif and Fab variable domains) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV7 Lambda None None None None None 7whi G NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 2 complex structure of Omicron spike with Bn03 (2-up RBD, 4 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6cnv C NA 0 A protein hemagglutinin VIRAL PROTEIN 03/09/18 INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX INFLUENZA B VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic construct influenza b virus Luo, J., Obmolova, G. 4.1 X-RAY DIFFRACTION 0.276 0.241 False True IGHV3 None None None None None 3qsk B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 02/21/11 5 Histidine Variant of the anti-RNase A VHH in Complex with RNAse A CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Murtaugh, M.L., Fanning, S.W., Sharma, T.M., Terry, A.M., Horn, J.R. 1.75 X-RAY DIFFRACTION 0.246 0.184 False True IGHV1 1.00e-07 -9.37 ITC 25 21766385 6hgu A B 0 IMMUNE SYSTEM 08/23/18 Crystal Structure of an anti-APP-tag Fab MUS MUSCULUS mus musculus mus musculus Rondeau, J.M., Goepfert, A. 1.5 X-RAY DIFFRACTION 0.207 0.187 False True IGHV8 IGKV1 Kappa None None None None None 3pp3 H L 0 IMMUNE SYSTEM 11/24/10 Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for the type I / type II distinction of anti- CD20 antibodies MUS MUSCULUS mus musculus mus musculus Hopfner, K.-P., Lammens, A. 2.508 X-RAY DIFFRACTION 0.269 0.206 False True IGHV1 IGKV2D Kappa None None None None None 7bc7 B NA 0 A protein NA proton-coupled folate transporter MEMBRANE PROTEIN 12/18/20 Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed GALLUS GALLUS; LAMA GLAMA lama glama gallus gallus Parker, J.L., Deme, J.C., Lea, S.M., Newstead, S. 3.3 ELECTRON MICROSCOPY NA NA False False IGHV3 NA NA None None None None None 2jb5 H L 0 H Hapten T5C 2-{(1E,3Z,5E,7E)-7-[3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-1,3-DIHYDRO-2H-INDOL-2-YLIDENE]-4-METHYLHEPTA-1,3,5-TRIEN-1-YL}-3,3-DIMETHYL-5-SULFO-1-(2-SULFOETHYL)-3H-INDOLIUM IMMUNE SYSTEM 12/03/06 Fab fragment in complex with small molecule hapten, crystal form-1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hillig, R.C., Baesler, S., Malawski, G., Badock, V., Bahr, I., Schirner, M., Licha, K. 2.8 X-RAY DIFFRACTION 0.2715 0.2112 False True IGHV1 IGLV2 Lambda 6e-10 -12.580852650099459 Unknown TBD 3oz9 H L 0 IMMUNE SYSTEM 09/24/10 Crystal Structure of anti-gp41 Fab NC-1 MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Calarese, D.A., Jiang, S., Wilson, I.A. 1.6 X-RAY DIFFRACTION 0.233 0.190 False False IGHV1 IGKV4 Kappa None None None None None 4xc1 H L 0 P peptide modified fragment of hiv-1 glycoprotein (gp41) includingthe mper region 671-683 IMMUNE SYSTEM 12/17/14 Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 GP41: crystals cryoprotected with sn-Glycerol 3-phosphate HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Stanfield, R.L., Wilson, I.A. 1.63 X-RAY DIFFRACTION 0.189 0.143 False True IGHV1 IGKV3 Kappa None None None None None 7k9j I M 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 09/29/20 SARS-CoV-2 Spike in complex with neutralizing Fab 2H04 (three down conformation) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Errico, J.M., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV5 Kappa None None None None None 7rp2 H I 0 A protein NA gtpase kras Hydrolase/Immune System 08/03/21 Crystal structure of Kas G12C in complex with 2H11 CLAMP HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oh, A., Tam, C., Wang, W. 2.2 X-RAY DIFFRACTION 0.225 0.208 False True IGHV4 IGLV1 Lambda None None None None None 6d11 A B 0 E peptide nanp5 IMMUNE SYSTEM 04/11/18 Crystal structure of 1450 Fab in complex with circumsporozoite protein NANP5 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Imkeller, K., Wardemann, H., Julien, J.P. 3.4 X-RAY DIFFRACTION 0.299 0.254 False True IGHV3 IGKV1 Kappa None None None None None 5mhr N G 0 F protein NA viral attachment protein sigma 1 IMMUNE SYSTEM 11/25/16 T3D reovirus sigma1 complexed with 9BG5 Fab fragments REOVIRUS SP.; MUS MUSCULUS mus musculus mus musculus reovirus sp. Stehle, T., Dietrich, M.H. 3.0 X-RAY DIFFRACTION 0.247 0.212 False False IGHV1 IGKV4 Kappa None None None None None 6cnj K J 0 E | D protein | protein NA | NA neuronal acetylcholine receptor subunit beta-2 | neuronal acetylcholine receptor subunit alpha-4 TRANSPORT PROTEIN 03/08/18 Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens | homo sapiens Walsh Jr, R.M., Roh, S.H., Gharpure, A., Morales-Perez, C.L., Teng, J., Hibbs, R.E. 3.4 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 4u6g H L 0 P peptide sah-mper(662-683kkk)(b,q) IMMUNE SYSTEM 07/28/14 Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Ofek, G., Bird, G.H., Walensky, L.D., Kwong, P.D. 4.2012 X-RAY DIFFRACTION 0.281 0.225 False True IGHV3 IGLV3 Lambda None None None None None 6ikm Q q 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 5w4l F I 0 A protein NA clade a/e 93th057 hiv-1 gp120 core VIRAL PROTEIN/IMMUNE SYSTEM 06/12/17 Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in complex with HIV-1 clade A/E gp120, the CD4 mimetic M48U1, and the antibody N5-i5. HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Gohain, N., Pazgier, M. 2.92 X-RAY DIFFRACTION 0.292 0.231 False True IGHV3 IGLV2 Lambda None None None None None 6tyl D NA 0 A protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 08/09/19 Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., McClelland, L., Yates-Hansen, C., Sprang, S.R. 3.3 X-RAY DIFFRACTION 0.287 0.248 False True IGHV1 None None None None None 3zl4 H L 0 01/28/13 Antibody structural organization: Role of kappa - lambda chain constant domain switch in catalytic functionality HOMO SAPIENS homo sapiens homo sapiens Chatziefthimiou, S.D., Ponomarenko, N.A., Kurkova, I.N., Smirnov, A.V., Smirnov, I.V., Lamzin, V.S., Gabibov, A.G., Wilmanns, M. 1.95 X-RAY DIFFRACTION 0.2546 0.2052 False True IGHV4 IGLV1 Lambda None None None None None 2old NA A 0 IMMUNE SYSTEM 01/19/07 Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(2)21 Crystal Form HOMO SAPIENS homo sapiens Makino, D.L., Larson, S.B., McPherson, A. 2.6 X-RAY DIFFRACTION 0.254 0.215 False False IGLV2 Lambda None None None None None 2x7l H L 0 N protein hiv rev IMMUNE SYSTEM 03/01/10 Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element UNCLASSIFIED; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 BH10 unclassified unclassified human immunodeficiency virus type 3 DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M. 3.17 X-RAY DIFFRACTION 0.2500 0.2337 False True IGHV1 IGKV1 Kappa None None None None None 5w42 H L 0 A protein hemagglutinin IMMUNE SYSTEM 06/08/17 Crystal structure of human monoclonal antibody H3v-47 in complex with influenza virus hemagglutinin from A/Minnesota/11/2010 (H3N2) INFLUENZA A VIRUS (A/SWINE/MINNESOTA/A01134337/2010(H3N2)); INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/swine/minnesota/a01134337/2010(h3n2)) Zhang, H., Wilson, I.A. 3.569 X-RAY DIFFRACTION 0.228 0.196 False True IGHV1 IGKV3 Kappa 4.43e-08 -10.032100252409448 SPR TBD 4kxz H L 0 A protein transforming growth factor beta-2 immune system 05/28/13 crystal structure of tgfb2 in complex with GC2008. HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mathieu, M., Moulin, A.G., Wei, R. 2.83 X-RAY DIFFRACTION 0.222 0.183 False True IGHV1 IGKV3 Kappa 3.0000000000000004e-09 -11.627286953008985 SPR TBD 7mzl H L 0 A protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab PDI 210 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Chan, L.J., Dietrich, M.H., Tan, L.L., Tham, W.H. 3.7 X-RAY DIFFRACTION 0.256 0.222 False True IGHV4 IGKV3 Kappa None None None None None 4weu D NA 0 B protein k88 fimbrial protein ad CELL ADHESION 09/11/14 Co-complex structure of the F4 fimbrial adhesin FaeG variant ad with llama single domain antibody V3 ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Moonens, K., Van den Broeck, I., Pardon, E., De Kerpel, M., Remaut, H., De Greve, H. 2.61 X-RAY DIFFRACTION 0.243 0.204 False True IGHV1 5.7e-06 -7.154266732276501 SPR TBD 4fp8 K O 0 D protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/21/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.947 X-RAY DIFFRACTION 0.241 0.212 False True IGHV3 IGKV1 Kappa None None None None None 2p8l B A 0 C peptide gp41 peptide viral protein 03/22/07 Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELLELDKWASLWN HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Julien, J.P., Bryson, S., Pai, E.F. 2.44 X-RAY DIFFRACTION 0.225 0.201 False False IGHV2 IGKV1 Kappa None None None None None 2r56 H L 0 A protein beta-lactoglobulin IMMUNE SYSTEM 09/03/07 Crystal Structure of a Recombinant IgE Fab Fragment in Complex with Bovine Beta-Lactoglobulin Allergen BOS TAURUS; HOMO SAPIENS homo sapiens homo sapiens bos taurus Niemi, M., Kallio, J.M., Hakulinen, N., Rouvinen, J. 2.8 X-RAY DIFFRACTION 0.291 0.246 False False IGHV3 IGKV1 Kappa 1.30e-09 -12.12 SPR 17997967 5vig A B 0 G protein zika virus envelope protein diii IMMUNE SYSTEM 04/16/17 Crystal structure of anti-Zika antibody Z006 bound to Zika virus envelope protein DIII ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Keeffe, J.R., West Jr., A.P., Gristick, H.B., Bjorkman, P.J. 3.0 X-RAY DIFFRACTION 0.257 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6kdi H L 0 A nucleic-acid 64T 5-HYDROXY-THYMIDINE-5'-MONOPHOSPHATE IMMUNE SYSTEM 07/02/19 Antibody 64M-5 Fab including isoAsp in complex with dT(6-4)T MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Yokoyama, H., Mizutani, R., Noguchi, S., Hayashida, N. 2.7 X-RAY DIFFRACTION 0.259 0.210 False False IGHV1 IGKV1 Kappa None None None None None 6e5p V W 0 A protein envelope glycoprotein gp120 VIRAL PROTEIN 07/21/18 Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Kwong, P.D. 8.8 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6kz0 E F 0 D protein genome polyprotein VIRAL PROTEIN 05/27/20 HRV14 3C in complex with single chain antibody GGVV HUMAN RHINOVIRUS 14; HOMO SAPIENS homo sapiens homo sapiens human rhinovirus 14 Meng, B., Yang, B., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.223 0.185 False True IGHV1 IGKV1 Kappa None None None None None 6hkg C D 0 IMMUNE SYSTEM 09/06/18 Structure of FISW84 Fab Fragment HOMO SAPIENS homo sapiens homo sapiens Benton, D.J., Rosenthal, P.B. 1.87 X-RAY DIFFRACTION 0.200 0.183 False True IGHV3 IGKV3 Kappa None None None None None 7ldj F NA 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 01/13/21 SARS-CoV-2 receptor binding domain in complex with WNb-2 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS vicugna pacos severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Adair, A., Tham, W.H. 2.36 X-RAY DIFFRACTION 0.268 0.210 False True IGHV1 NA NA None None None None None 3bdx NA B 0 IMMUNE SYSTEM 11/15/07 Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2 HOMO SAPIENS homo sapiens Hernandez-Santoyo, A., Fuentes-Silva, D., Del Pozo Yauner, L., Becerril, B., Rodriguez-Romero, A. 2.3 X-RAY DIFFRACTION 0.246 0.205 False True IGLV6 Lambda None None None None None 5f9d C NA 0 A protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain P436 in complex with Lewis b blood group B heptasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.59 X-RAY DIFFRACTION 0.234 0.195 False True IGHV1 None None None None None 5jz7 J K 0 E protein beta-nerve growth factor SIGNALING PROTEIN 05/16/16 NGF IN COMPLEX WITH MEDI578 scFv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Olsson, L.-L., Aagaard, A. 3.4 X-RAY DIFFRACTION 0.268 0.258 False True IGHV1 IGLV1 Lambda None None None None None 6oya N NA 0 A | B protein | protein NA | NA gt-alpha/gi1-alpha chimera | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/IMMUNE SYSTEM 05/14/19 Structure of the Rhodopsin-Transducin-Nanobody Complex BOS TAURUS; LAMA GLAMA lama glama bos taurus | bos taurus Gao, Y., Hu, H., Ramachandran, S., Erickson, J.W., Cerione, R.A., Skiniotis, G. 3.3 ELECTRON MICROSCOPY False True IGHV3 None None None None None 5u7o D E 0 B protein envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 12/12/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer bound to small molecule HIV-1 entry inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 A HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Pancera, M., Lai, Y.-T., Kwong, P.D. 3.031 X-RAY DIFFRACTION 0.325 0.272 False True unknown unknown unknown 7.3e-08 -9.736169606109948 Unknown TBD 1vhp A NA 0 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 7bq5 C D 0 B protein NA envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 03/24/20 ZIKV sE bound to mAb Z6 ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus Dai, L., Qi, J., Gao, G.F. 2.99 X-RAY DIFFRACTION 0.275 0.261 False True IGHV4 IGKV1 Kappa None None None None None 2kqm NA B 1 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 1n0x H L 0 P peptide b2.1 peptide IMMUNE SYSTEM 10/15/02 Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Saphire, E.O., Montero, M., Menendez, A., Irving, M.B., Zwick, M.B., Parren, P.W.H.I., Burton, D.R., Scott, J.K., Wilson, I.A. 1.8 X-RAY DIFFRACTION 0.252 0.220 False True IGHV1 IGKV3 Kappa None None None None None 5vm4 C NA 0 UNKNOWN FUNCTION 04/26/17 The apo form of the triclocarban-binding single domain camelid nanobody VHH T10 LAMA GLAMA lama glama Tabares-da Rosa, S., Gonzalez-Sapienza, G., Wilson, D.K. 1.9 X-RAY DIFFRACTION 0.241 0.197 False True unknown unknown unknown None None None None None 7akd D E 0 C protein NA spike glycoprotein VIRAL PROTEIN 09/30/20 Structure of the SARS-CoV-2 spike glycoprotein in complex with the 47D11 neutralizing antibody Fab fragment SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Fedry, J., Hurdiss, D.L., Wang, C., Li, W., Obal, G., Drulyte, I., Howes, S.C., van Kuppeveld, F.J.M., Foerster, F., Bosch, B.J. 4 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 7whi F NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/30/21 The state 2 complex structure of Omicron spike with Bn03 (2-up RBD, 4 nanobodies) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens severe acute respiratory syndrome coronavirus2 Zhan, W.Q., Zhang, X., Chen, Z.G., Sun, L. 2.93 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6uym A B 0 F protein envelope glycoprotein e2 VIRAL PROTEIN/IMMUNE SYSTEM 11/13/19 Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v6 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C HEPATITIS C VIRUS (ISOLATE H); HOMO SAPIENS homo sapiens homo sapiens hepatitis c virus (isolate h) Tzarum, N., Wilson, I.A., Zhu, J. 2.848 X-RAY DIFFRACTION 0.260 0.215 False True IGHV1 IGKV3 Kappa None None None None None 5i8h K L 0 C protein bg505 sosip.664 gp120 IMMUNE SYSTEM 02/18/16 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Zhou, T., Kwong, P.D. 4.301 X-RAY DIFFRACTION 0.309 0.281 False True IGHV4 IGLV3 Lambda None None None None None 5tbd J K 0 L peptide merozoite surface protein 2 IMMUNE SYSTEM 09/12/16 Crystal Structure of anti-MSP2 Fv fragment (mAb4D11) in complex with 3D7-MSP2 215-222 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum 3d7 Seow, J., Morales, R.A.V., MacRaild, C.A., Bankala, K., Drinkwater, N., Dingjan, T., Jaipuria, G., Wilde, K., Anders, R.F., Atreya, H.S., Christ, D., McGowan, S., Norton, R.S. 2.2 X-RAY DIFFRACTION 0.247 0.207 False True IGHV14 IGKV1 Kappa None None None None None 2i9l H G 0 L protein virion membrane protein m25 IMMUNE SYSTEM/VIRAL PROTEIN 09/05/06 Structure of Fab 7D11 from a neutralizing antibody against the poxvirus L1 protein VACCINIA VIRUS; MUS MUSCULUS mus musculus mus musculus vaccinia virus Su, H.P., Golden, J.W., Gittis, A.G., Moss, B., Hooper, J.W., Garboczi, D.N. 3.1 X-RAY DIFFRACTION 0.259 0.240 False False IGHV1 IGKV8 Kappa None None None None None 3fku Z z 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 12/17/08 Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens influenza a virus | influenza a virus Hwang, W.C., Santelli, E., Stec, B., Wei, G., Cadwell, G., Bankston, L.A., Sui, J., Perez, S., Aird, D., Chen, L.M., Ali, M., Murakami, A., Yammanuru, A., Han, T., Cox, N., Donis, R.O., Liddington, R.C., Marasco, W.A. 3.2 X-RAY DIFFRACTION 0.286 0.232 True True unknown unknown unknown 1.30E-10 -13.48 SPR 25 19234466 2vxu H L 0 IMMUNE SYSTEM 07/10/08 Crystal structure of murine reference antibody 125-2H Fab fragment MUS MUSCULUS mus musculus mus musculus Argiriadi, M.A., Xiang, T., Wu, C., Ghayur, T., Borhani, D.W. 2.36 X-RAY DIFFRACTION 0.242 0.184 False True IGHV1 IGKV9 Kappa None None None None None 7a0v B NA 0 A protein NA synaptojanin-1 HYDROLASE 08/11/20 Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Paesmans, J., Galicia, C., Martin, E., Versees, W. 2.3 X-RAY DIFFRACTION 0.252 0.196 False True IGHV1 NA NA None None None None None 1uwg Y X 0 Y Hapten KHA 1-(4-{[(2-HYDROXYETHYL)AMINO]CARBONYL}BENZYL)-1-METHYLPIPERIDINIUM ANTIBODY 02/05/04 Molecular Mechanism of Enantioselective Proton Transfer to Carbon in Catalytic Antibody 14D9 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Baumann, , U, , Reymond, , Jl, 2.79 X-RAY DIFFRACTION 0.276 0.204 False True IGHV1 IGKV6 Kappa None None None None None 7jxe H L 0 NA NA NA NA IMMUNE SYSTEM 08/27/20 Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology HOMO SAPIENS homo sapiens homo sapiens Tortorici, M.A., Park, Y.J., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D. 2.043 X-RAY DIFFRACTION 0.251 0.199 False True IGHV1 IGLV1 Lambda None None None None None 7n9v J NA 0 I protein NA capsid protein VIRAL PROTEIN/IMMUNE SYSTEM 06/18/21 CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions Human immunodeficiency virus 1; Lama glama lama glama human immunodeficiency virus 1 Tripler, T.N. 3.45 X-RAY DIFFRACTION 0.258 0.212 False True IGHV1 NA NA None None None None None 5hdo D NA 0 IMMUNE SYSTEM 01/05/16 Crystal structure of a nanobody raised against urokinase-type plasminogen activator CAMELUS DROMEDARIUS camelus dromedarius Kromann-Hansen, T. 2.16 X-RAY DIFFRACTION 0.218 0.177 False True IGHV1 None None None None None 6w4y NA A 0 A unknown 7ZW unknown IMMUNE SYSTEM 03/11/20 Structure of full-length human lambda-6A light chain JTO in complex with hydantoin stabilizer HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Morgan, G.J., Kelly, J.W. 1.91 X-RAY DIFFRACTION 0.232 0.181 False True NA IGLV6 Lambda None None None None None 6qv0 E NA 0 B | A protein | protein NA | NA uncharacterized abc transporter atp-binding proteintm_0288 | abc transporter, atp-binding protein MEMBRANE PROTEIN 03/01/19 Structure of ATP-bound outward-facing TM287/288 in complex with sybody Sb_TM35 THERMOTOGA MARITIMA (STRAIN ATCC 43589 / MSB8 / DSM 3109 / JCM 10099); SYNTHETIC CONSTRUCT synthetic construct thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) | thermotoga maritima (strain atcc 43589 / msb8 /dsm 3109 / jcm 10099) Hutter, C.A.J., Huerlimann, L.M., Zimmermann, I., Egloff, P., Seeger, M.A. 3.12 X-RAY DIFFRACTION 0.264 0.244 False True IGHV1 NA NA None None None None None 1axs H L 0 H Hapten HOP (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL CATALYTIC ANTIBODY 10/20/97 MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN HOMO SAPIENS homo sapiens homo sapiens homo sapiens Mundorff, E.C., Ulrich, H.D., Stevens, R.C. 2.6 X-RAY DIFFRACTION 0.305 0.200 False True IGHV1 IGKV14 Kappa 1.7e-08 -10.599564136380756 Unknown TBD 5nml G NA 0 IMMUNE SYSTEM 04/06/17 Nb36 Ser85Cys with Hg bound LAMA GLAMA lama glama Hansen, S.B., Andersen, K.R., Laursen, N.S., Andersen, G.R. 2.5 X-RAY DIFFRACTION 0.265 0.238 False True IGHV1 None None None None None 3cfe B A 0 IMMUNE SYSTEM 03/03/08 Crystal structure of purple-fluorescent antibody EP2-25C10 MUS MUSCULUS mus musculus mus musculus Debler, E.W., Heine, A., Wilson, I.A. 2.99 X-RAY DIFFRACTION 0.255 0.211 False False IGHV3 IGKV10 Kappa None None None None None 7e88 J K 0 L protein NA spike protein s1 VIRAL PROTEIN,IMMUNE SYSTEM 03/01/21 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-515 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Gao, C., Wei, Y., Xiao, J. 3.14 X-RAY DIFFRACTION 0.255 0.217 False True IGHV3 IGKV1 Kappa None None None None None 1ieh A NA 2 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 4ocs H L 0 IMMUNE SYSTEM 01/09/14 Crystal structure of human Fab CAP256-VRC26.10, a potent V1V2-directed HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Gorman, J., Doria-Rose, N.A., Schramm, C.A., Moore, P.L., Mascola, J.R., Shapiro, L., Morris, L., Kwong, P.D. 1.901 X-RAY DIFFRACTION 0.241 0.210 False True IGHV3 IGLV1 Lambda None None None None None 6ev1 A B 0 IMMUNE SYSTEM 11/01/17 Crystal structure of antibody against schizophyllan MUS MUSCULUS mus musculus mus musculus Sung, K.H., Josewski, J., Dubel, S., Blankenfeldt, W., Rau, U. 3.043 X-RAY DIFFRACTION 0.238 0.186 False True IGHV1 IGKV4 Kappa None None None None None 7sfv S T 0 K protein NA spike glycoprotein e2 VIRUS/IMMUNE SYSTEM 10/04/21 CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83); HOMO SAPIENS homo sapiens homo sapiens venezuelan equine encephalitis virus (straintc-83) Binshtein, E., Crowe, J.E. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV3 Lambda None None None None None 5o4o B A 0 C protein receptor tyrosine-protein kinase erbb-3 IMMUNE SYSTEM 05/30/17 HER3 in complex with Fab MF3178 HOMO SAPIENS homo sapiens homo sapiens homo sapiens De Nardis, C., Gros, P. 3.4 X-RAY DIFFRACTION 0.261 0.215 False True IGHV1 IGKV1 Kappa None None None None None 1maj NA A 11 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 5m76 NA A 0 IMMUNE SYSTEM 10/26/16 Crystal structure of cardiotoxic Bence-Jones light chain dimer H10 HOMO SAPIENS homo sapiens Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. 2.5 X-RAY DIFFRACTION 0.282 0.239 False False unknown unknown None None None None None 6y92 H L 0 A protein NA b-lymphocyte antigen cd20 MEMBRANE PROTEIN 03/06/20 Structure of full-length CD20 in complex with Ofatumumab Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Kumar, A., Reyes, N. 4.73 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 6ikm M m 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 6ii4 E F 0 C protein hemagglutinin IMMUNE SYSTEM 10/03/18 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L4A-14 INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Jiang, H.H., Shi, Y., Qi, J., Gao, G.F. 3.3 X-RAY DIFFRACTION 0.276 0.227 False True IGHV3 IGLV6 Lambda 1.6600000000000003e-08 -10.613671557141997 SPR TBD 3pp4 H L 0 P peptide b-lymphocyte antigen cd20 IMMUNE SYSTEM 11/24/10 Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for the type I / type II distinction of anti- CD20 antibodies MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Hopfner, K.-P., Lammens, A. 1.6 X-RAY DIFFRACTION 0.187 0.137 False True IGHV1 IGKV2D Kappa 7.00e-06 ITC 25 21444918 6uce H L 0 C peptide hiv fusion peptide IMMUNE SYSTEM/VIRAL PROTEIN 09/16/19 N123-VRC34_pI3 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Xu, K., Kwong, P.D. 1.382 X-RAY DIFFRACTION 0.204 0.180 False True IGHV1 IGKV1 Kappa None None None None None 6vvu G I 0 D protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 02/18/20 Anti-Tryptase fab E104.v1 bound to tryptase HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Koerber, J.T. 3.0 X-RAY DIFFRACTION 0.232 0.187 False True IGHV4 IGKV1 Kappa None None None None None 6oyz F NA 0 B protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to capuramycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.62 X-RAY DIFFRACTION 0.301 0.277 False True IGHV1 None None None None None 5ijv B A 0 IMMUNE SYSTEM 03/02/16 Crystal structure of bovine Fab E03 BOS TAURUS bos taurus bos taurus Stanfield, R.L., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.247 0.204 False True IGHV1 IGLV1 Lambda None None None None None 5ebm A B 0 C protein ph-gated potassium channel kcsa MEMBRANE PROTEIN 10/19/15 KcsA T75G mutant in the nonconductive state MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Matulef, K., Valiyaveetil, F.I. 2.5 X-RAY DIFFRACTION 0.251 0.216 False True IGHV1 IGKV5 Kappa None None None None None 2kh2 B b 76 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5ye4 C D 0 F peptide di-acetylated histone h4 NUCLEAR PROTEIN 09/15/17 Crystal structure of the complex of di-acetylated histone H4 and 1A9D7 Fab fragment MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Matsuda, T., Ito, T., Wakamori, M., Umehara, T. 1.799 X-RAY DIFFRACTION 0.224 0.194 False True IGHV9 IGKV19 Kappa None None None None None 4hg4 X Y 0 H protein hemagglutinin ha2 VIRAL PROTEIN/IMMUNE SYSTEM 10/06/12 Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Xu, R., Wilson, I.A. 3.2 X-RAY DIFFRACTION 0.302 0.249 False True IGHV1 IGKV1 Kappa None None None None None 6jbt H L 0 F protein programmed cell death protein 1 IMMUNE SYSTEM 01/26/19 Complex structure of toripalimab-Fab and PD-1 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Guo, L., Tan, S., Chai, Y., Qi, J., Gao, G.F., Yan, J. 2.47 X-RAY DIFFRACTION 0.252 0.201 False True IGHV1 IGKV1 Kappa None None None None None 7rlw A B 0 P peptide NA pvcspvk210 peptide from circumsporozoite protein ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2F2 in complex with P. vivax CSP peptide GDRAAGQPAGDRAAGQPA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Julien, J.P. 2.54 X-RAY DIFFRACTION 0.253 0.201 False True IGHV1 IGKV1 Kappa None None None None None 5a16 A B 0 04/28/15 Crystal structure of Fab4201 raised against Human Erythrocyte Anion Exchanger 1 MUS MUSCULUS mus musculus mus musculus Arakawa, T., Kobayashi-Yugiri, T., Alguel, Y., Weyand, S., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Ikeda-Suno, C., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A., Kobayashi, T., Hamasaki, N., Iwata, S. 2.5 X-RAY DIFFRACTION 0.2552 0.2128 False False IGHV8 IGKV3 Kappa None None None None None 6wiz H L 0 B | A protein | protein NA | NA hemagglutinin ha2 | hemagglutinin ha1 IMMUNE SYSTEM 04/11/20 Crystal structure of Fab 54-1G05 bound to H1 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Wu, N.C., Wilson, I.A. 4.2 X-RAY DIFFRACTION 0.389 0.323 False True IGHV6 IGKV3 Kappa None None None None None 6vpx K N 0 I | A peptide | protein NA | NA mper peptide | envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/04/20 Nanodisc of full-length HIV-1 Envelope glycoprotein clone AMC011 in complex with one PGT151 Fab and three 10E8 Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens homo sapiens | human immunodeficiency virus 1 Rantalainen, K., Ward, A.B.W. 5.0 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 1yjd H L 0 C protein t-cell-specific surface glycoprotein cd28 IMMUNE SYSTEM/SIGNALING PROTEIN 01/14/05 Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Evans, E.J., Esnouf, R.M., Manso-Sancho, R., Gilbert, R.J.C., James, J.R., Sorensen, P., Stuart, D.I., Davis, S.J. 2.7 X-RAY DIFFRACTION 0.282 0.239 False False IGHV1 IGKV10 Kappa None None None None None 5gs1 C c 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 5m2m E NA 0 C protein tumor necrosis factor CYTOKINE 10/13/16 Complex between human TNF alpha and Llama VHH3 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.3 X-RAY DIFFRACTION 0.248 0.211 False True IGHV1 1.5000000000000002e-09 -12.037965345328766 SPR TBD 7qjj C NA 0 A protein NA divalent metal cation transporter MEMBRANE PROTEIN 12/16/21 X-Ray Structure of a Mn2+ soak of EleNRMT in complex with two Nanobodies at 4.6A EGGERTHELLA LENTA eggerthella lenta eggerthella lenta Ramanadane, K., Straub, M.S., Dutzler, R., Manatschal, C. 4.6 X-RAY DIFFRACTION 0.327 0.284 False True IGHV1 NA NA None None None None None 6iw2 H I 0 G protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state YELLOW FEVER VIRUS (STRAIN 17D VACCINE); HOMO SAPIENS homo sapiens homo sapiens yellow fever virus (strain 17d vaccine) Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 2.9 X-RAY DIFFRACTION 0.272 0.238 False True IGHV4 IGKV1 Kappa None None None None None 7tqb H L 0 A | B nucleic-acid | nucleic-acid NA | NA rna | dna IMMUNE SYSTEM/DNA-RNA HYBRID 01/26/22 Crystal structure of monoclonal S9.6 Fab bound to DNA-RNA hybrid SYNTHETIC CONSTRUCT; SYNTHETIC CONSTRUCT synthetic construct synthetic construct synthetic construct | synthetic construct Bou Nader, C., Zhang, J. 3.1 X-RAY DIFFRACTION 0.272 0.229 False True IGHV1 IGKV1 Kappa None None None None None 6yu8 B NA 0 A protein NA methyltransferase domain of the l protein TRANSFERASE 04/25/20 RNA Methyltransferase of Sudan Ebola Virus SUDAN VIRUS - BONIFACE; LAMA GLAMA lama glama sudan virus - boniface Ferron, F., Valle, C., Zamboni, V., Canard, B., Decroly, E. 1.841 X-RAY DIFFRACTION 0.215 0.195 False False IGHV1 NA NA None None None None None 1ocw H L 0 IMMUNE SYSTEM 02/11/03 Free conformation Ab2 of the IgE SPE-7 RATTUS RATTUS rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.0 X-RAY DIFFRACTION unknown unknown False True IGHV1 IGLV1 Lambda None None None None None 7sqo E e 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 MEMBRANE PROTEIN 11/05/21 Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16 HOMO SAPIENS; BOS TAURUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | bos taurus | bos taurus McGrath, A.P., Kang, Y., Flinspach, M. 3.17 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4rzc C D 0 C carbohydrate M6P ALPHA-D-MANNOSE-6-PHOSPHATE IMMUNE SYSTEM 12/19/14 Fv M6P-1 in complex with mannose-6-phosphate ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Blackler, R.J., Evans, D.W., Evans, S.V., Muller-Loennies, S. 2.723 X-RAY DIFFRACTION 0.267 0.226 False True IGHV1 IGKV1 Kappa None None None None None 6xdg C A 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/10/20 Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Franklin, M.C., Saotome, K., Romero Hernandez, A., Zhou, Y. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 6ek2 I i 0 B protein cd81 antigen CELL ADHESION 09/25/17 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 10 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Harris, S.F., Villasenor, A., Kuglstatter, A. 2.65 X-RAY DIFFRACTION 0.247 0.179 True True unknown unknown unknown None None None None None 6nnj D E 0 B protein envelope glycoprotein gp41 IMMUNE SYSTEM 01/15/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to CH31 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.1 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.6 X-RAY DIFFRACTION 0.293 0.248 False True unknown unknown unknown None None None None None 5etu B A 0 IMMUNE SYSTEM 11/18/15 Cetuximab Fab in complex with L5E meditope variant MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.53 X-RAY DIFFRACTION 0.232 0.180 False True IGHV2 IGKV5 Kappa 0.00013 -5.301529812728825 Unknown TBD 5l7x H L 0 L carbohydrate NAG N-ACETYL-D-GLUCOSAMINE IMMUNE SYSTEM 06/04/16 Afamin antibody fragment, N14 Fab, L1- glycosylated, crystal form II MUS MUSCULUS mus musculus mus musculus mus musculus Rupp, B., Naschberger, A. 1.86 X-RAY DIFFRACTION 0.228 0.190 False False IGHV1 IGKV4 Kappa None None None None None 4hj0 P Q 0 A protein gastric inhibitory polypeptide receptor IMMUNE SYSTEM 10/12/12 Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution HOMO SAPIENS homo sapiens homo sapiens homo sapiens Madhurantakam, C., Ravn, P., Gruetter, M.G., Jackson, R.H. 3.0 X-RAY DIFFRACTION 0.311 0.255 False True IGHV1 IGLV1 Lambda 2.3e-08 -10.420467653019871 SPR TBD 6mar H L 0 D | C protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 MEMBRANE PROTEIN 08/28/18 HIV-1 Envelope Glycoprotein Clone BG505 delCT N332T in complex with broadly neutralizing antibody Fab PGT151 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T., Ward, A.B. 4.5 ELECTRON MICROSCOPY False True IGHV3 IGKV2 Kappa None None None None None 7lab T S 0 A protein NA spike glycoprotein VIRAL PROTEIN, IMMUNE SYSTEM 01/06/21 Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1052 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Acharya, P. 2.97 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5i1i H L 0 IMMUNE SYSTEM 02/05/16 CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-53/IGKV4-1 HOMO SAPIENS homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Luo, J., Gilliland, G. 2.5 X-RAY DIFFRACTION 0.337 0.250 False True IGHV3 IGKV4 Kappa None None None None None 7l0n H L 0 R protein NA spike protein s1 VIRAL PROTEIN/HYDROLASE 12/11/20 Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Snell, G., Czudnochowski, N., Dillen, J., Nix, J.C., Croll, T.I., Corti, D. 2.78 X-RAY DIFFRACTION 0.325 0.290 False True IGHV3 IGKV1 Kappa None None None None None 6qtl D NA 0 D Hapten CFF CAFFEINE BIOSYNTHETIC PROTEIN 04/10/19 Caffeine recognizing nanobody CAMELIDAE camelidae camelidae Lesne, J., Guichou, J.F., Labesse, G., Cohen-Gonsaud, M. 2.25 X-RAY DIFFRACTION 0.259 0.194 False True IGHV1 None None None None None 5i76 D C 0 IMMUNE SYSTEM 02/16/16 Crystal structure of FM318, a recombinant Fab adopted from cetuximab HOMO SAPIENS/MUS MUSCULUS XENOGRAFT homo sapiens/mus musculus xenograft homo sapiens/mus musculus xenograft Sim, D.W., Kim, J.H., Seok, S.H., Seo, M.D., Kim, Y.P., Won, H.S. 1.922 X-RAY DIFFRACTION 0.201 0.166 False True IGHV2 IGKV5 Kappa None None None None None 4s2s A B 0 IMMUNE SYSTEM 01/22/15 Crystal Structure of Fab fragment of monoclonal antibody RoAb13 MUS MUSCULUS mus musculus mus musculus Chain, B., Arnold, J., Akthar, S., Noursadeghi, M., Lapp, T., Ji, C., Naider, D., Zhang, Y., Govada, L., Saridakis, E., Chayen, N.E. 2.1 X-RAY DIFFRACTION 0.234 0.186 False False IGHV5 IGKV8 Kappa None None None None None 2wzp F NA 0 C protein putative receptor binding protein VIRAL PROTEIN 12/01/09 Structures of Lactococcal Phage p2 Baseplate Shed Light on a Novel Mechanism of Host Attachment and Activation in Siphoviridae LACTOCOCCUS PHAGE P2; LAMA GLAMA lama glama lactococcus phage p2 Sciara, G., Bebeacua, C., Bron, P., Tremblay, D., Ortiz-Lombardia, M., Lichiere, J., van Heel, M., Campanacci, V., Moineau, S., Cambillau, C. 2.6 X-RAY DIFFRACTION 0.2078 0.1789 False True IGHV1 None None None None None 2p43 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.65A resolution: SE3-mono-1 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 1.65 X-RAY DIFFRACTION 0.202 0.158 False True IGHV1 2.30e-08 -10.59 Other 30 18445622 7neq D C 0 B protein NA atp-binding cassette sub-family g member 2 MEMBRANE PROTEIN 02/04/21 Structure of tariquidar-bound ABCG2 HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Kowal, J., Locher, K. 3.12 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV13 Kappa None None None None None 6ea5 Q R 0 VIRAL PROTEIN/immune system 08/02/18 Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878 BUNDIBUGYO EBOLAVIRUS; HOMO SAPIENS homo sapiens homo sapiens King, L.B., West, B.R., Moyer, C.L., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O. 4.75 X-RAY DIFFRACTION 0.305 0.295 False True IGHV3 IGKV1 Kappa None None None None None 2kqn NA A 10 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7m2h D E 0 F protein NA ph-gated potassium channel kcsa TRANSPORT PROTEIN/IMMUNE SYSTEM 03/16/21 Structural Snapshots of Intermediates in the Gating of a K+ Channel MUS MUSCULUS; STREPTOMYCES LIVIDANS mus musculus mus musculus streptomyces lividans Reddi, R., Valiyaveetil, F.I. 2.642 X-RAY DIFFRACTION 0.268 0.237 False True IGHV1 IGKV5 Kappa None None None None None 4ydj H L 0 G protein envelope glycoprotein gp160,envelope glycoprotein gp160 IMMUNE SYSTEM 02/22/15 Crystal structure of broadly and potently neutralizing antibody 44-VRC13.01 in complex with HIV-1 clade AE strain 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.308 X-RAY DIFFRACTION 0.250 0.223 False True unknown IGLV2 Lambda None None None None None 6rvc D NA 0 A protein protein patched homolog 1 MEMBRANE PROTEIN 05/31/19 Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Rudolf, A.F., Kowatsch, C., El Omari, K., Malinauskas, T., Kinnebrew, M., Ansell, T.B., Bishop, B., Pardon, E., Schwab, R.A., Qian, M., Duman, R., Covey, D.F., Steyaert, J., Wagner, A., Sansom, M.S.P., Rohatgi, R., Siebold, C. 2.2 X-RAY DIFFRACTION 0.241 0.204 False True IGHV1 None None None None None 3ejz E F 0 B protein h(+)/cl(-) exchange transporter clca IMMUNE SYSTEM/PROTON TRANSPORT 09/18/08 Structure of E203V mutant E.coli Cl-/H+ exchanger, CLC-ec1 ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.9 X-RAY DIFFRACTION 0.281 0.252 False False IGHV4 IGKV4 Kappa None None None None None 6csf A B 0 C protein sodium/alanine symporter agcs MEMBRANE PROTEIN 03/20/18 Crystal structure of sodium/alanine symporter AgcS with D-alanine bound METHANOCOCCUS MARIPALUDIS (STRAIN S2 / LL); MUS MUSCULUS mus musculus mus musculus methanococcus maripaludis (strain s2 / ll) Ma, J., Reyes, F.E., Gonen, T. 3.3 X-RAY DIFFRACTION 0.253 0.240 False False IGHV6 IGKV12 Kappa None None None None None 5v8m H L 0 A protein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/22/17 A broadly neutralizing antibody targets the dynamic HIV Envelope trimer apex via a long, rigidified, and anionic beta-hairpin structure HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Lee, J.H., Cottrell, C.A., Ward, A.B. 4.4 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 2qtj C O 2 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4fp8 J N 0 C protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 06/21/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 2.947 X-RAY DIFFRACTION 0.241 0.212 False True IGHV3 IGKV1 Kappa None None None None None 6ani H L 0 IMMUNE SYSTEM 08/13/17 Coltuximab Fab in complex with anti-Kappa VHH domain LAMA GLAMA; HOMO SAPIENS homo sapiens homo sapiens Ereno Orbea, J., Sicard, T., Julien, J.-P. 2.4 X-RAY DIFFRACTION 0.286 0.245 False True IGHV1 IGKV4 Kappa 7.8e-09 -11.061162015777013 Unknown TBD 1bln D C 0 IMMUNE SYSTEM 07/16/98 ANTI-P-GLYCOPROTEIN FAB MRK-16 MUS MUSCULUS mus musculus mus musculus Vasudevan, S., Tsuruo, T., Rose, D.R. 2.8 X-RAY DIFFRACTION 0.287 0.209 False False IGHV5 IGKV1 Kappa None None None None None 3hzv B A 0 A carbohydrate KDA polysaccharide IMMUNE SYSTEM 06/24/09 Crystal structure of S73-2 antibody in complex with antigen Kdo(2.8)Kdo(2.4)Kdo MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Muller-Loennies, S., Borisova, S.N., Brade, L., Kosma, P., Hirama, T., MacKenzie, C.R., Brade, H., Evans, S.V. 1.9 X-RAY DIFFRACTION 0.249 0.212 False False IGHV7 IGKV8 Kappa 3e-07 -8.898798774188476 Unknown TBD 6jri D NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 6zfo H L 0 E protein NA spike glycoprotein IMMUNE SYSTEM 06/17/20 Association of two complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 4.4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6v4n D E 0 W protein NA neuraminidase VIRAL PROTEIN 11/28/19 Structure of human 1G05 Fab in complex with influenza virus neuraminidase from B/Phuket/3073/2013 INFLUENZA B VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza b virus Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 2.5 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 4ptu B A 0 B carbohydrate RAM ALPHA-L-RHAMNOSE IMMUNE SYSTEM 03/11/14 Crystal Structure of anti-23F strep Fab C05 with rhamnose HOMO SAPIENS homo sapiens homo sapiens homo sapiens Bryson, S., Risnes, L., Damgupta, S., Thomson, C.A., Smith, K., Schrader, J.W., Pai, E.F. 1.511 X-RAY DIFFRACTION 0.206 0.179 False True IGHV3 IGKV3 Kappa None None None None None 6hdc A NA 0 TRANSPORT PROTEIN 08/17/18 Crystal structure of the potassium channel MtTMEM175 T38A variant in complex with a Nanobody-MBP fusion protein LAMA GLAMA; ESCHERICHIA COLI (STRAIN K12); MARIVIRGA TRACTUOSA DSM 4126 lama glama, escherichia coli (strain k12) Brunner, J.D., Jakob, R.P., Schulze, T., Neldner, Y., Moroni, A., Thiel, G., Maier, T., Schenck, S. 3.4 X-RAY DIFFRACTION 0.292 0.273 False True IGHV1 None None None None None 4ywg H L 0 G protein scaffold hiv-1 gp120 v1v2 region derived from strain zm109 Viral protein/Immune system 03/20/15 Crystal structure of 830A in complex with V1V2 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Pan, R., Kong, X. 2.998 X-RAY DIFFRACTION 0.296 0.219 False True IGHV4 IGKV3 Kappa None None None None None 6w0i A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Closed-gate KcsA soaked in 10mM KCl/5mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 2.328 X-RAY DIFFRACTION 0.232 0.200 False True IGHV1 IGKV5 Kappa None None None None None 5szf H L 0 IMMUNE SYSTEM 08/13/16 2A10 FAB fragment 2.54 Angstoms HOMO SAPIENS homo sapiens homo sapiens Jackson, C.J., Fisher, C. 2.52 X-RAY DIFFRACTION 0.248 0.225 False True IGHV9 IGKV10 Kappa None None None None None 3auv C c 0 IMMUNE SYSTEM 02/16/11 Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface HOMO SAPIENS homo sapiens Yu, C.M., Peng, H.P., Chen, I.C., Lee, Y.C., Chen, J.B., Tsai, K.C., Chen, C.T., Chang, J.Y., Yang, E.W., Hsu, P.C., Jian, J.W., Hsu, H.J., Chang, H.J., Hsu, W.L., Huang, K.F., Ma, A.C., Yang, A.S. 2.4 X-RAY DIFFRACTION 0.251 0.216 True True unknown unknown unknown None None None None None 2qtj A L 0 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4c57 D NA 0 B protein cyclin-g-associated kinase TRANSFERASE 09/10/13 Structure of GAK kinase in complex with a nanobody HOMO SAPIENS; SYNTHETIC CONSTRUCT lama glama homo sapiens Chaikuad, A., Keates, T., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S. 2.55 X-RAY DIFFRACTION 0.2281 0.1776 False False IGHV3 None None None None None 4d9q H L 0 A protein factor d HYDROLASE/IMMUNE SYSTEM 01/11/12 Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D MACACA MULATTA; HOMO SAPIENS homo sapiens homo sapiens macaca mulatta Murray, J.M., Wiesmann, C. 2.28 X-RAY DIFFRACTION 0.230 0.189 False True IGHV7 IGKV1 Kappa 3e-11 -14.355775131829494 SPR TBD 7rco D C 0 B protein NA transforming growth factor beta-2 IMMUNE SYSTEM 07/07/21 Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yin, J., Lupardus, P.J., Sudhamsu, J. 2.9 X-RAY DIFFRACTION 0.286 0.208 False True IGHV3 IGKV1 Kappa None None None None None 4g7y H L 0 S protein voltage-sensor containing phosphatase membrane protein 07/20/12 Crystal structure of voltage sensing domain of Ci-VSP with fragment antibody (R217E, 2.8 A) CIONA INTESTINALIS; HOMO SAPIENS homo sapiens homo sapiens ciona intestinalis Li, Q. 2.8 X-RAY DIFFRACTION 0.261 0.206 False True IGHV3 IGKV1 Kappa None None None None None 4xx1 E G 0 B protein phosphatidylcholine-sterol acyltransferase Hydrolase/Immune system 01/29/15 Low resolution structure of LCAT in complex with Fab1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T. 3.6 X-RAY DIFFRACTION 0.280 0.196 False True IGHV3 IGLV3 Lambda None None None None None 7fcp B D 0 A protein NA spike protein s1 ANTIVIRAL PROTEIN 07/15/21 Crystallographic structure of two neutralizing antibodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zheng, P., Jin, T. 2.4 X-RAY DIFFRACTION 0.245 0.191 False True IGHV3 IGKV1 Kappa None None None None None 6x87 C D 0 X protein NA circumsporozoite protein IMMUNE SYSTEM 06/01/20 CryoEM structure of the Plasmodium berghei circumsporozoite protein in complex with inhibitory mouse antibody 3D11. MUS MUSCULUS; PLASMODIUM BERGHEI mus musculus mus musculus plasmodium berghei Kucharska, I., Thai, E., Rubinstein, J., Julien, J.P. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5dt1 H L 0 L carbohydrate NAG polysaccharide IMMUNE SYSTEM 09/17/15 Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gorman, J., Kwong, P.D. 1.954 X-RAY DIFFRACTION 0.215 0.169 False True IGHV3 IGLV1 Lambda None None None None None 5jyl B b 0 A protein cadherin-3 CELL ADHESION/IMMUNE SYSTEM 05/14/16 Human P-cadherin MEC1 with scFv TSP7 bound MUS MUSCULUS; HOMO SAPIENS mus musculus homo sapiens Caaveiro, J.M.M., Kudo, S., Tsumoto, K. 2.55 X-RAY DIFFRACTION 0.271 0.214 True True unknown unknown unknown 8.7e-09 -10.996463217420198 SPR TBD 6ol7 A Q 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV5 IGKV8 Kappa None None None None None 7lez G I 0 A | C protein | protein NA | NA arginase-1 | arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens | homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 4.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 7eh5 J N 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/28/21 Cryo-EM structure of SARS-CoV-2 S-D614G variant in complex with neutralizing antibodies, RBD-chAb15 and RBD-chAb45 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Yang, T.J., Yu, P.Y., Chang, Y.C., Wu, H.C., Hsu, S.T.D. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 6ibl C NA 0 A protein thioredoxin 1,beta-1 adrenergic receptor IMMUNE SYSTEM 11/30/18 ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY Nb80 ESCHERICHIA COLI (STRAIN K12); MELEAGRIS GALLOPAVO; LAMA GLAMA lama glama escherichia coli (strain k12), meleagrisgallopavo Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G. 2.7 X-RAY DIFFRACTION 0.277 0.240 False True IGHV1 None None None None None 6wzl A B 0 E protein NA c-x-c motif chemokine 7 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL7 HOMO SAPIENS; MACACA FASCICULARIS homo sapiens homo sapiens macaca fascicularis Durbin, J.D., Druzina, Z. 2.29 X-RAY DIFFRACTION 0.222 0.193 False True IGHV1 IGKV3 Kappa None None None None None 7kkk F NA 0 E protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/27/20 SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium 3.03 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 3zkx C NA 0 A protein beta-secretase 2 HYDROLASE 01/25/13 TERNARY BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kuglstatter, A., Banner, D.W., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski, D., Gsell, B., Hilpert, H., Huber, W., Kusznir, E., Laeremans, T., Matile, H., Rufer, A., Schlatter, D., Steyeart, J., Stihle, M., Thoma, R., Weber, M., Ruf, A. 2.37 X-RAY DIFFRACTION 0.2085 0.1849 False True IGHV3 None None None None None 2mkw NA A 2 IMMUNE SYSTEM 02/13/14 Solution Structure of 6aJl2 and 6aJL2-R24G Amyloidogenics Light Chain Proteins HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 4f37 F K 0 B protein colicin-e7 immunity protein IMMUNE SYSTEM 05/09/12 Structure of the tethered N-terminus of Alzheimer's disease A peptide MUS MUSCULUS; ESCHERICHIA COLI mus musculus mus musculus escherichia coli Nisbet, R.M., Nuttall, S.D., Caine, J.M., Rober, R., Hittaki, M., Pearce, L.A., Davydova, N., Masters, C.L., Varghese, J.N., Streltsov, V.A. 2.57 X-RAY DIFFRACTION 0.269 0.223 False True IGHV8 IGKV1 Kappa 5.5000000000000004e-09 -11.268161381529886 SPR TBD 7f8w D d 0 B | A | C protein | protein | peptide NA | NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 STRUCTURAL PROTEIN 07/02/21 Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens | homo sapiens | homo sapiens Zhang, X., He, C., Wang, M., Zhou, Q., Yang, D., Zhu, Y., Wu, B., Zhao, Q. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1wt5 B D 0 IMMUNE SYSTEM 11/16/04 The Crystal Structure Of A Humanized Antibody Fv 528 HOMO SAPIENS homo sapiens homo sapiens Makabe, K., Tsumoto, K., Asano, R., Kondo, H., Kumagai, I. 2.1 X-RAY DIFFRACTION 0.301 0.273 False True IGHV1 IGKV2 Kappa None None None None None 7vl9 S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/02/21 Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens Shao, Z., Shen, Q., Mao, C., Yao, B., Chen, L., Zhang, H., Shen, D., Zhang, C., Li, W., Du, X., Li, F., Ma, H., Chen, Z., Xu, H.E., Ying, S., Zhang, Y., Shen, H. 2.6 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 4r2g Q P 0 E protein surface protein gp160 IMMUNE SYSTEM 08/11/14 Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (JRCSF ISOLATE); HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus type 1 (jrcsfisolate) Garces, F., Wilson, I.A. 3.283 X-RAY DIFFRACTION 0.263 0.207 False True IGHV4 IGLV3 Lambda 3.4e-08 -10.188885744060974 ITC TBD 6w4w H L 0 NA NA NA NA IMMUNE SYSTEM 03/11/20 Crystal Structure of the Fab fragment of humanized 5c8 antibody HOMO SAPIENS homo sapiens homo sapiens Henderson, J.N., Mills, J.H., Simmons, C.R. 1.77 X-RAY DIFFRACTION 0.204 0.169 False True IGHV1 IGKV3 Kappa None None None None None 2y36 H L 0 P peptide dodecapeptide (dlwttaiptips) IMMUNE SYSTEM 12/18/10 Crystal structure analysis of the anti-(4-hydroxy-3-nitrophenyl)- acetyl murine germline antibody BBE6.12H3 Fab fragment in complex with a phage display derived dodecapeptide DLWTTAIPTIPS MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus synthetic construct Khan, T., Salunke, D.M. 2.7 X-RAY DIFFRACTION 0.2477 0.2305 False False IGHV1 IGLV1 Lambda 3.7999999999999996e-07 -8.758742281050278 Unknown TBD 7w9e D E 0 C protein NA spike glycoprotein VIRAL PROTEIN 12/09/21 SARS-CoV-2 Delta S-8D3 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV6 Kappa None None None None None 7tcc J K 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 12/23/21 Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, T., Kwong, P.D. 3.86 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1jpt H L 0 IMMUNE SYSTEM 08/03/01 Crystal Structure of Fab D3H44 HOMO SAPIENS homo sapiens homo sapiens Faelber, K., Kirchhofer, D., Presta, L., Kelley, R.F., Muller, Y.A. 1.85 X-RAY DIFFRACTION 0.228 0.182 False True IGHV3 IGKV1 Kappa None None None None None 2q1e NA B 0 PROTEIN FIBRIL 05/24/07 Altered dimer interface decreases stability in an amyloidogenic kappa1 Bence Jones protein. HOMO SAPIENS homo sapiens Thompson, J.R., Ramirez-Alvarado, M., Baden, E.M. 2.55 X-RAY DIFFRACTION 0.206 0.165 False True IGKV1 Kappa None None None None None 7ej0 H h 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(o) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/01/21 Structure of the alpha2A-adrenergic receptor GoA signaling complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Xu, J., Cao, S., Liu, Z., Du, Y. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5ivo A NA 0 PEPTIDE BINDING PROTEIN 03/21/16 BC2 nanobody VICUGNA PACOS vicugna pacos Braun, M.B., Stehle, T. 1.8 X-RAY DIFFRACTION 0.222 0.187 False True IGHV1 None None None None None 7duo H L 0 B protein NA adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 ANTITUMOR PROTEIN/HYDROLASE 01/10/21 Crystal structure of daratumumab fab and CD38 complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yu, X.J., Wang, L., Yu, C.F. 2.81 X-RAY DIFFRACTION 0.238 0.231 False True IGHV3 IGKV3 Kappa None None None None None 4qnp E F 0 B | A protein | protein NA | NA neuraminidase | neuraminidase HYDROLASE/IMMUNE SYSTEM 06/18/14 Crystal structure of the 2009 pandemic H1N1 influenza virus neuraminidase with a neutralizing antibody INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus | influenza a virus Wan, H.Q., Yang, H., Shore, D.A., Garten, R.J., Couzens, L., Gao, J., Jiang, L.L., Carney, P.J., Villanueva, J., Stevens, J., Eichelberger, M.C. 2.8 X-RAY DIFFRACTION 0.224 0.181 False True IGHV10 IGKV4 Kappa None None None None None 4hzl A B 0 F peptide e2 envelop protein IMMUNE SYSTEM 11/15/12 Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein MUS MUSCULUS; RECOMBINANT HEPATITIS C VIRUS H77(5'UTR-NS2)/JFH1_V787A,Q1247L mus musculus mus musculus recombinant hepatitis c virus h77(5'utr-ns2)/jfh1_v787a,q1247l Deng, L., Zhang, P. 2.85 X-RAY DIFFRACTION 0.277 0.221 False False IGHV5 IGKV1 Kappa None None None None None 5mv3 U V 0 W peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii,collagen alpha-1(ii) chain,synthetic peptide containing the cii583-591 epitope of collagen type ii, IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.95 X-RAY DIFFRACTION 0.261 0.202 False False IGHV6 IGKV3 Kappa None None None None None 7e3k D E 0 A protein NA spike glycoprotein VIRAL PROTEIN 02/09/21 Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Guo, H., Li, T., Liu, F., Gao, Y., Ji, X., Yang, H. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6uht C NA 0 A protein botulinum neurotoxin type b TOXIN/ANTITOXIN 09/28/19 Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.20001 X-RAY DIFFRACTION 0.211 0.194 False True IGHV1 None None None None None 6qx4 E NA 0 B protein s-layer protein sap STRUCTURAL PROTEIN 03/07/19 Structure of the Bacillus anthracis Sap S-layer assembly domain BACILLUS ANTHRACIS; LAMA GLAMA lama glama bacillus anthracis Remaut, H., Fioravanti, A. 3.27 X-RAY DIFFRACTION 0.218 0.173 False True IGHV1 None None None None None 2kqm NA B 12 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7jtr B b 0 A protein NA maltose/maltodextrin-binding periplasmic protein SUGAR BINDING PROTEIN/IMMUNE SYSTEM 08/18/20 Complex of maltose-binding protein (MBP) with single-chain Fv (scFv) MUS MUSCULUS; ESCHERICHIA COLI mus musculus escherichia coli Loll, P.J. 2.5 X-RAY DIFFRACTION 0.237 0.201 True True unknown unknown unknown None None None None None 6ikm I i 0 ANTIMICROBIAL PROTEIN 10/16/18 Crystal structure of SpuE-Spermidine in complex with ScFv5 PSEUDOMONAS AERUGINOSA; HOMO SAPIENS pseudomonas aeruginosa homo sapiens Wu, D., Sun, X. 3.398 X-RAY DIFFRACTION 0.268 0.228 True True unknown unknown unknown None None None None None 7ll2 K M 0 E protein NA envelope glycoprotein gp120 IMMUNE SYSTEM/VIRAL PROTEIN 02/03/21 Cryo-EM structure of BG505 DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody VRC33.01 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Manne, K., Acharya, P. 3.73 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 7n8h C B 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/14/21 SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6nc3 R W 0 M | F protein | protein NA | NA hiv-1 env amc011 v4.2 sosip gp41 | hiv-1 env amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Torres, J.L., Ward, A.B. 4.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7n4i H L 0 C protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/04/21 Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2057. HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Sankhala, R.S., Joyce, M.G. 2.284 X-RAY DIFFRACTION 0.238 0.200 False True IGHV5 IGKV1 Kappa None None None None None 7niv E D 0 A protein NA isoform 2 of phosphatidylcholine translocator abcb4 PROTEIN TRANSPORT 02/14/21 Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Nosol, K., Locher, K.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 7wpf R S 0 B protein NA spike glycoprotein VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with three JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.92 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 7vaf H L 0 A protein NA sodium/bile acid cotransporter TRANSPORT PROTEIN 08/29/21 Cryo-EM structure of Rat NTCP complexed with YN69202Fab MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Asami, J., Shimizu, T., Ohto, U. 3.11 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 7dwu H L 0 A protein NA envelope protein VIRUS/IMMUNE SYSTEM 01/18/21 Cryo-EM structure of Dengue virus serotype 1 strain WestPac 74 in complex with human antibody 1C19 Fab at 37 deg C (Class 2 particle) DENGUE VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens dengue virus 1 Fibriansah, G., Ng, T.S., Kostyuchenko, V.A., Shi, J., Lok, S.M. 19 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV1 Kappa None None None None None 2vdp H L 0 A protein integrin alpha-iib CELL ADHESION/IMMUNE SYSTEM 10/10/07 Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide,LGGAKQAGDV HOMO SAPIENS; MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Springer, T., Zhu, J., Xiao, T. 2.8 X-RAY DIFFRACTION 0.204 0.156 False False IGHV14 IGKV14 Kappa None None None None None 6ivz H L 0 A protein envelope protein VIRAL PROTEIN/IMMUNE SYSTEM 12/04/18 Crystal structure of 5A ScFv complexed with YFV-China sE in postfusion state YELLOW FEVER VIRUS; HOMO SAPIENS homo sapiens homo sapiens yellow fever virus Lu, X.S., Xiao, H.X., Li, S.H., Pang, X.F. 2.4 X-RAY DIFFRACTION 0.256 0.210 False True IGHV4 IGKV1 Kappa None None None None None 4r7d I J 0 IMMUNE SYSTEM 08/27/14 Fab Hu 15C1 HOMO SAPIENS homo sapiens homo sapiens Loyau, J., Didelot, G., Malinge, P., Ravn, U., Magistrelli, G., Depoisier, J.F., Kosco-Vilbois, M., Fischer, N., Thore, S., Rousseau, F. 2.753 X-RAY DIFFRACTION 0.209 0.177 False True IGHV4 IGKV6 Kappa None None None None None 5j3d C D 0 I | G protein | protein NA | NA fusion glycoprotein f0 | fusion glycoprotein f0 IMMUNE SYSTEM 03/30/16 Crystal structure of human Fab 14N4 in complex with post-fusion RSV F HOMO SAPIENS; HUMAN RESPIRATORY SYNCYTIAL VIRUS A homo sapiens homo sapiens human respiratory syncytial virus a | human respiratory syncytial virus a Mousa, J.J., Crowe, J.E. 4.077 X-RAY DIFFRACTION 0.282 0.257 False True IGHV3 IGKV1 Kappa None None None None None 6j5d H L 0 A protein envelope VIRAL PROTEIN/IMMUNE SYSTEM 01/10/19 Complex structure of MAb 4.2-scFv with louping ill virus envelope protein Domain III LOUPING ILL VIRUS; MUS MUSCULUS mus musculus mus musculus louping ill virus Yang, X., Qi, J., Peng, R., Dai, L., Gould, E.A., Tien, P., Gao, G.F. 1.8 X-RAY DIFFRACTION 0.189 0.170 False True IGHV1 IGKV12 Kappa None None None None None 1ynt B A 0 F | E protein | protein NA | NA major surface antigen p30 | protein l IMMUNE SYSTEM 01/25/05 Structure of the immunodominant epitope displayed by the surface antigen 1 (SAG1) of Toxoplasma gondii complexed to a monoclonal antibody FINEGOLDIA MAGNA; TOXOPLASMA GONDII; MUS MUSCULUS mus musculus mus musculus toxoplasma gondii | finegoldia magna Graille, M., Stura, E.A., Bossus, M., Muller, B.H., Letourneur, O., Battail-Poirot, N, Sibai, G., Rolland, D., Le Du, M.H., Ducancel, F. 3.1 X-RAY DIFFRACTION 0.283 0.241 False False IGHV1 IGKV10 Kappa None None None None None 5esv A B 0 E protein 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase,envelope glycoprotein gp160 IMMUNE SYSTEM 11/17/15 Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade C Superinfecting Strain of Donor CAP256. HOMO SAPIENS; HAEMOPHILUS INFLUENZAE homo sapiens homo sapiens haemophilus influenzae, human immunodeficiencyvirus 1, haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd) Gorman, J., Yang, M., Kwong, P.D. 3.105 X-RAY DIFFRACTION 0.259 0.209 False True IGHV3 IGKV3 Kappa None None None None None 6zcz H L 0 E protein NA spike glycoprotein VIRAL PROTEIN 06/12/20 Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in ternary complex with EY6A Fab and a nanobody. SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 2.65 X-RAY DIFFRACTION 0.260 0.215 False True IGHV3 IGKV1 Kappa None None None None None 1cd0 NA B 0 IMMUNE SYSTEM 03/05/99 STRUCTURE OF HUMAN LAMDA-6 LIGHT CHAIN DIMER JTO HOMO SAPIENS homo sapiens Pokkuluri, P.R., Solomon, A., Weiss, D.T., Stevens, F.J., Schiffer, M. 1.9 X-RAY DIFFRACTION 0.240 0.184 False True IGLV6 Lambda None None None None None 4w68 A NA 0 NA NA NA NA IMMUNE SYSTEM 08/20/14 Cytoplasmically Produced Homodimeric Single Domain Antibody (sdAb) C22A/C99V variant against Staphylococcal enterotoxin B (SEB) LAMA GLAMA lama glama George, J., Legler, P.M. 2.0 X-RAY DIFFRACTION 0.242 0.199 False True IGHV1 NA NA None None None None None 7nw3 H L 0 A peptide NA region from c-c chemokine receptor type 5 n-terminaldomain IMMUNE SYSTEM 03/16/21 X-ray crystallographic study of PIYDIN, which contains the truncation determinants of binding PI and N, bound to RoAb13, a CCR5 antibody MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Saridakis, E., Helliwell, J.R., Govada, L., Chayen, N.E. 3.20001 X-RAY DIFFRACTION 0.293 0.268 False False IGHV5 IGKV8 Kappa None None None None None 3nfs H L 0 IMMUNE SYSTEM 06/10/10 Crystal structure the Fab fragment of therapeutic antibody daclizumab HOMO SAPIENS homo sapiens homo sapiens Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J. 2.6 X-RAY DIFFRACTION 0.275 0.225 False True IGHV1 IGKV1 Kappa None None None None None 6bla H L 0 IMMUNE SYSTEM 11/09/17 Structure of AMM01 Fab, an anti EBV gH/gL neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Pancera, M., Weidle, C. 1.55 X-RAY DIFFRACTION 0.194 0.166 False True IGHV1 IGLV3 Lambda None None None None None 6gg0 H L 0 4 | 3 protein | protein NA | NA capsid protein vp1 | capsid protein vp1 VIRUS LIKE PARTICLE 05/02/18 Cryo-EM structure of BK polyomavirus like particle in complex with single chain antibody ScFv41F17 BK POLYOMAVIRUS; HOMO SAPIENS homo sapiens homo sapiens bk polyomavirus | bk polyomavirus Srinivas, H. 4.24 ELECTRON MICROSCOPY False True IGHV4 IGKV3 Kappa None None None None None 3twc H L 0 H Hapten AML AMYLAMINE IMMUNE SYSTEM 09/21/11 Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pejchal, R., Wilson, I.A. 1.65 X-RAY DIFFRACTION 0.215 0.192 False True IGHV4 IGLV2 Lambda None None None None None 2p47 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: SE5B-TRI crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 2.5 X-RAY DIFFRACTION 0.294 0.230 False True IGHV1 1.16e-07 -9.61 Other 30 18445622 3chn D N 9 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7kn6 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH V and antibody Fab CC12.3 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; VICUGNA PACOS; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Yuan, M., Zhu, X., Wu, N.C., Wilson, I.A. 2.55 X-RAY DIFFRACTION 0.239 0.193 False True IGHV3 IGKV3 Kappa None None None None None 7a50 A NA 0 B peptide NA coiled-coil aph DE NOVO PROTEIN 08/20/20 Crystal structure of the APH coiled-coil in complex with nanobody Nb26 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 1.999 X-RAY DIFFRACTION 0.226 0.182 False True IGHV1 NA NA None None None None None 2kqm NA B 2 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5mu0 K L 0 V peptide ia03 peptide containing the citrullinated c1 epitope ofcollagen type ii,collagen alpha-1(ii) chain,ia03 peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/11/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.279 0.252 False False IGHV6 IGKV3 Kappa None None None None None 7n0h X NA 0 A protein NA spike glycoprotein VIRAL PROTEIN 05/25/21 CryoEM structure of SARS-CoV-2 spike protein (S-6P, 2-up) in complex with sybodies (Sb45) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Jiang, J., Huang, R., Margulies, D. 3.34 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6jri G NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 6x03 C NA 0 NA NA NA NA STRUCTURAL PROTEIN 05/15/20 Nup84-Nup133 (aa521-1157) from S. cerevisiae bound by VHH-SAN8 and VHH-SAN9 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos Nordeen, S.A., Schwartz, T.U. 7.3 X-RAY DIFFRACTION 0.353 0.335 False True IGHV1 NA NA None None None None None 6qd8 W Z 0 D | C protein | protein NA | NA envelope glycoprotein | envelope glycoprotein,virion spike glycoprotein,ebov-gp1 VIRAL PROTEIN 01/01/19 EM structure of a EBOV-GP bound to 4M0368 neutralizing antibody HOMO SAPIENS; EBOLA VIRUS homo sapiens homo sapiens ebola virus | ebola virus Diskin, R., Cohen-Dvashi, H. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV1 Kappa None None None None None 4x4z NA B 0 IMMUNE SYSTEM 12/04/14 Retrofitting antibodies with stabilizing mutations. Herceptin VL mutant F53D. HOMO SAPIENS homo sapiens Langley, D.B., Rouet, R., Christ, D. 1.8 X-RAY DIFFRACTION 0.213 0.177 False True IGKV1 Kappa None None None None None 3iet B A 0 X peptide podoplanin IMMUNE SYSTEM 07/23/09 Crystal Structure of 237mAb with antigen MUS MUSCULUS mus musculus mus musculus mus musculus Brooks, C.L., Evans, S.V., Borisova, S.N. 2.2 X-RAY DIFFRACTION 0.271 0.227 False True IGHV6 IGKV1 Kappa 1.4e-07 -9.350354316900614 Unknown TBD 1yyl R Q 0 P protein exterior membrane glycoprotein(gp120) Viral protein/Immune system 02/25/05 crystal structure of CD4M33, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Huang, C.C., Stricher, F., Martin, L., Decker, J.M., Majeed, S., Barthe, P., Hendrickson, W.A., Robinson, J., Roumestand, C., Sodroski, J., Wyatt, R., Shaw, G.M., Vita, C., Kwong, P.D. 2.75 X-RAY DIFFRACTION 0.275 0.202 False True IGHV1 IGKV3 Kappa 4.00e-09 -11.9 ITC 37 15893666 5ifa H L 0 IMMUNE SYSTEM 02/25/16 Crystal structure of unbound VRC01c-HuGL2 Fab from an HIV-1 naive donor at 1.82 A HOMO SAPIENS homo sapiens homo sapiens Sarkar, A., Wilson, I.A. 1.821 X-RAY DIFFRACTION 0.240 0.205 False True IGHV1 IGKV4 Kappa None None None None None 7rt9 A B 0 Y peptide NA peptide yy HORMONE/IMMUNE SYSTEM 08/12/21 Crystal structures of human PYY and NPY HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Langley, D.B., Christ, D. 1.9 X-RAY DIFFRACTION 0.213 0.179 False True IGHV3 IGKV1 Kappa None None None None None 7d7m E NA 0 D | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/05/20 Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Nojima, S., Fujita, Y., Kimura, T.K., Nomura, N., Suno, R., Morimoto, K., Yamamoto, M., Noda, T., Iwata, S., Shigematsu, H., Kobayashi, T. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 4fqr g h 0 G protein broadly neutralizing antibody c05, heavy chain VIRAL PROTEIN/IMMUNE SYSTEM 06/25/12 Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Ekiert, D.C., Wilson, I.A. 4.1 X-RAY DIFFRACTION 0.334 0.309 False False IGHV3 IGKV1 Kappa 1.0000000000000001e-07 -9.54970862587178 SPR TBD 6ute C D 0 S protein envelope domain iii VIRAL PROTEIN 10/29/19 Crystal structure of Z032 Fab in complex with WNV EDIII HOMO SAPIENS; WEST NILE VIRUS homo sapiens homo sapiens west nile virus Esswein, S.R., Gristick, H.B., Keeffe, J.R., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 3sn6 N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/Hydrolase 06/28/11 Crystal structure of the beta2 adrenergic receptor-Gs protein complex BOS TAURUS; ENTEROBACTERIA PHAGE T4, HOMO SAPIENS; LAMA GLAMA; RATTUS NORVEGICUS lama glama bos taurus | rattus norvegicus Rasmussen, S.G.F., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., Thian, F.S., Chae, P.S., Pardon, E., Calinski, D., Mathiesen, J.M., Shah, S.T.A., Lyons, J.A., Caffrey, M., Gellman, S.H., Steyaert, J., Skiniotis, G., Weis, W.I., Sunahara, R.K., Kobilka, B.K. 3.2 X-RAY DIFFRACTION 0.277 0.226 False True IGHV1 None None None None None 6oro J K 0 I protein NA rc1 variant of hiv-1 env glycoprotein gp120 VIRAL PROTEIN/Immune System 04/30/19 Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 Abernathy, M.E., Gristick, H.B., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 5gs1 E e 0 IMMUNE SYSTEM 08/13/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.0 X-RAY DIFFRACTION 0.286 0.267 True True unknown unknown unknown None None None None None 6w4v C D 0 NA NA NA NA IMMUNE SYSTEM 03/11/20 Structure of anti-ferroportin Fab45D8 MUS MUSCULUS mus musculus mus musculus Billesboelle, C.B., Azumaya, C.M., Gonen, S., Powers, A., Kretsch, R.C., Schneider, S., Arvedson, T., Dror, R.O., Cheng, Y., Manglik, A. 2.1 X-RAY DIFFRACTION 0.247 0.216 False True IGHV3 IGKV3 Kappa None None None None None 1p7k H L 0 IMMUNE SYSTEM 05/02/03 Crystal structure of an anti-ssDNA antigen-binding fragment (Fab) bound to 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES) MUS MUSCULUS mus musculus mus musculus Schuermann, J.P., Henzl, M.T., Deutscher, S.L., Tanner, J.J. 1.75 X-RAY DIFFRACTION 0.230 0.197 False True IGHV1 IGKV12 Kappa None None None None None 6ey6 N NA 0 F protein t9ss component cytoplasmic membrane protein porm PROTEIN TRANSPORT 11/10/17 C-terminal part (residues 315-516) of PorM with the llama naobody nb130 PORPHYROMONAS GINGIVALIS; LAMA GLAMA lama glama porphyromonas gingivalis Leone, P., Cambillau, C., Roussel, A. 2.1 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 None None None None None 7m53 H L 0 A peptide NA spike glycoprotein stem helix peptide ANTIVIRAL PROTEIN, IMMUNE SYSTEM 03/22/21 B6 Fab fragment bound to the SARS-CoV/-2 spike stem helix peptide MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Sauer, M.M., Park, Y.J., Veesler, D., Center for Structural Genomics of Infectious Diseases (CSGID), Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.4 X-RAY DIFFRACTION 0.174 0.144 False True IGHV1 IGKV8 Kappa None None None None None 7luc J K 0 A protein NA fusion glycoprotein f0 IMMUNE SYSTEM/VIRAL PROTEIN 02/22/21 Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B RESPIRATORY SYNCYTIAL VIRUS; HOMO SAPIENS homo sapiens homo sapiens respiratory syncytial virus Wrapp, D., McLellan, J.S. 3.21 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 7mji E NA 0 B protein NA spike glycoprotein Viral Protein/Immune System 04/20/21 Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 (focused refinement of RBD and VH ab8) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Zhu, X., Mannar, D., Srivastava, S.S., Berezuk, A.M., Demers, J.P., Saville, J.W., Leopold, K., Li, W., Dimitrov, D.S., Tuttle, K.S., Zhou, S., Chittori, S., Subramaniam, S. 2.81 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3b2u J K 0 I protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 3zlq D NA 0 B protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 02/04/13 BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kuglstatter, A., Stihle, M. 2.1 X-RAY DIFFRACTION 0.29601 0.23825 False True IGHV3 None None None None None 6rlo E F 0 K protein NA cd9 antigen IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop HOMO SAPIENS homo sapiens homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.2 X-RAY DIFFRACTION 0.287 0.254 False True IGHV3 IGKV4 Kappa None None None None None 6tco B A 0 IMMUNE SYSTEM 11/06/19 Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form I HOMO SAPIENS homo sapiens homo sapiens Mitropoulou, A.N., Ceska, T., Beavil, A.J., Henry, A.J., McDonnell, J.M., Sutton, B.J., Davies, A.M. 1.8 X-RAY DIFFRACTION 0.192 0.168 False True IGHV3 IGKV1 Kappa None None None None None 3idy H L 0 G protein hiv-1 hxbc2 gp120 core IMMUNE SYSTEM 07/22/09 Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C2221 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chen, L., Kwon, Y.D., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z.Y., Zhang, M.Y., Arthos, J., Burton, D.R., Dimitrov, D.S., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D. 3.2 X-RAY DIFFRACTION 0.237 0.196 False True IGHV3 IGKV1 Kappa 4.04e-09 -11.450944611411623 SPR TBD 7lzp G NA 0 A protein NA botulinum neurotoxin a light chain ANTITOXIN 03/10/21 LC/A-JPU-B9-JPU-A11-JPU-G11 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 2.86 X-RAY DIFFRACTION 0.273 0.235 False True unknown unknown unknown None None None None None 5lcv H L 0 A | B protein | protein NA | NA polyprotein | polyprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/22/16 Structural basis of Zika and Dengue virus potent antibody cross-neutralization ZIKA VIRUS; HOMO SAPIENS homo sapiens homo sapiens zika virus | zika virus Barba-Spaeth, G. 2.64 X-RAY DIFFRACTION 0.237 0.224 False True IGHV3 IGLV2 Lambda 8.4e-07 -8.288766072897529 BLI TBD 2a9m I M 0 IMMUNE SYSTEM 07/12/05 Structural Analysis of a Tight-binding Fluorescein-scFv; apo form HOMO SAPIENS homo sapiens homo sapiens Cambillau, C., Spinelli, S., Honegger, A., Pluckthun, A. 2.1 X-RAY DIFFRACTION 0.263 0.210 True True IGHV3 IGLV1 Lambda None None None None None 7cky N NA 0 A | B | G protein | protein | protein NA | NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 CELL CYCLE 07/20/20 Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens | homo sapiens Yan, W., Shao, Z. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 3bd4 NA B 0 IMMUNE SYSTEM 11/14/07 Crystal structure of single domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals MUS MUSCULUS mus musculus Park, S.K., Kim, J.S. 2.4 X-RAY DIFFRACTION 0.281 0.213 True True IGKV8 Kappa None None None None None 7n8q C D 0 A protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 06/15/21 Rhesusized RV305 DH677.3 Fab bound to Clade A/E 93TH057 HIV-1 gp120 core. HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; SYNTHETIC CONSTRUCT macaca mulatta macaca mulatta human immunodeficiency virus 1 Tolbert, W.D., Pazgier, M. 2.9 X-RAY DIFFRACTION 0.296 0.255 False True IGHV1 IGKV1 Kappa None None None None None 6vvu H L 0 A protein NA tryptase alpha/beta-1 HYDROLASE/IMMUNE SYSTEM 02/18/20 Anti-Tryptase fab E104.v1 bound to tryptase HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ultsch, M., Koerber, J.T. 3.0 X-RAY DIFFRACTION 0.232 0.187 False True IGHV4 IGKV1 Kappa None None None None None 3gbn H L 0 B | A protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 02/20/09 Crystal Structure of Fab CR6261 in Complex with the 1918 H1N1 influenza virus hemagglutinin INFLUENZA A VIRUS (A/BREVIG MISSION/1/1918(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/brevigmission/1/1918(h1n1)) | influenza a virus (a/brevigmission/1/1918(h1n1)) Ekiert, D.C., Elsliger, M.A., Wilson, I.A. 2.2 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 IGLV1 Lambda None None None None None 6mph f h 0 A protein pgt122 light chain VIRAL PROTEIN 10/06/18 Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122 MACACA MULATTA; HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Acharya, P., Xu, K., Kwong, P.D. 3.8 ELECTRON MICROSCOPY False False unknown IGKV3 Kappa None None None None None 6lz2 B NA 0 A protein NA thermostable green fluorescent protein FLUORESCENT PROTEIN 02/17/20 Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb44) GALAXEA FASCICULARIS; LAMA GLAMA lama glama galaxea fascicularis Cai, H., Yao, H., Li, T., Hutter, C., Tang, Y., Li, Y., Seeger, M., Li, D. 2.03 X-RAY DIFFRACTION 0.215 0.175 False True IGHV1 NA NA None None None None None 6u38 H L 0 B protein proprotein convertase subtilisin/kexin type 9 HYDROLASE/Immune System 08/21/19 PCSK9 in complex with a Fab and compound 8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Lu, J., Soisson, S. 2.73 X-RAY DIFFRACTION 0.243 0.227 False True IGHV3 IGKV3 Kappa None None None None None 6okp M N 0 D protein envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 04/14/19 B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 3.28 ELECTRON MICROSCOPY False True IGHV4 IGKV3 Kappa None None None None None 6n5d E F 0 B protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 11/21/18 Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Bajic, G., Schmidt, A.G. 3.0 X-RAY DIFFRACTION 0.244 0.217 False True IGHV5 IGLV1 Lambda None None None None None 6qno H L 0 A | B | G protein | protein | peptide NA | NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(t) subunit gamma-t1 SIGNALING PROTEIN 02/11/19 Rhodopsin-Gi protein complex HOMO SAPIENS; MUS MUSCULUS; BOS TAURUS mus musculus mus musculus homo sapiens | bos taurus | bos taurus Tsai, C.-J., Marino, J., Adaixo, R.J., Pamula, F., Muehle, J., Maeda, S., Flock, T., Taylor, N.M.I., Mohammed, I., Matile, H., Dawson, R.J.P., Deupi, X., Stahlberg, H., Schertler, G.F.X. 4.38 ELECTRON MICROSCOPY False True IGHV5 IGKV2 Kappa None None None None None 4m61 D C 0 IMMUNE SYSTEM 08/08/13 Crystal structure of unliganded anti-DNA Fab A52 MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Eilat, D., Wilson, I.A. 1.62 X-RAY DIFFRACTION 0.232 0.192 False False IGHV1 IGKV8 Kappa None None None None None 6e62 B C 0 A protein pf48/45 IMMUNE SYSTEM 07/23/18 Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody 85RF45.1 PLASMODIUM FALCIPARUM; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus plasmodium falciparum Kundu, P., Semesi, A., Julien, J.P. 2.7 X-RAY DIFFRACTION 0.276 0.246 False True IGHV5 IGLV3 Lambda 3.2000000000000005e-09 -11.589048932503637 SPR TBD 4kk9 C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 05/05/13 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 2mM Bromide ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Lim, H.-H., Miller, C. 2.997 X-RAY DIFFRACTION 0.270 0.217 False True IGHV4 IGKV4 Kappa None None None None None 6b5o H L 0 A peptide pfcsp peptide 29 IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 29 with human protective antibody CIS43 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 2.194 X-RAY DIFFRACTION 0.240 0.193 False True IGHV1 IGKV4 Kappa 4.66e-09 -11.3663552684029 Unknown TBD 7x6l H L 0 F | C protein | protein NA | NA hemagglutinin | hemagglutinin STRUCTURAL PROTEIN 03/07/22 Cryo-EM structure of H3 hemagglutinin from A/HongKong/01/1968 in complex with a neutralizing antibody 28-12 HOMO SAPIENS; INFLUENZA A VIRUS (A/HONG KONG/1/1968(H3N2)); INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus (a/hong kong/1/1968(h3n2)) Cong, Y., Liu, C.X. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6b5n H L 0 A peptide pfcsp peptide 25asp IMMUNE SYSTEM 09/29/17 Structure of PfCSP peptide 25 with human protective antibody CIS43 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pancera, M., Weidle, C. 1.98 X-RAY DIFFRACTION 0.209 0.175 False True IGHV1 IGKV4 Kappa None None None None None 6rlm E F 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 6ss2 H L 0 A protein NA unknown PROTEIN BINDING 09/06/19 Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158 HOMO SAPIENS Burschowsky, D., Addyman, A., Fiedler, S., Groves, M., Haynes, S., Seewooruthun, C., Carr, M. 2.4 X-RAY DIFFRACTION 0.284 0.254 False False IGHV3 IGLV1 Lambda None None None None None 7rth e NA 0 NA NA NA NA IMMUNE SYSTEM 08/13/21 Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab ""NabFab"" HOMO SAPIENS homo sapiens Filippova, E.V., Mukherjee, S., Bloch, J.S., Locher, K.P., Kossiakoff, A.A. 3.19 X-RAY DIFFRACTION 0.267 0.216 False False IGHV1 NA NA None None None None None 6j5g H L 0 A protein envelope protein e VIRAL PROTEIN/IMMUNE SYSTEM 01/10/19 Complex structure of MAb 4.2-scFv with tick-borne encephalitis virus envelope protein TICK-BORNE ENCEPHALITIS VIRUS EUROPEAN SUBTYPE (STRAIN NEUDOERFL); MUS MUSCULUS mus musculus mus musculus tick-borne encephalitis virus european subtype(strain neudoerfl) Yang, X., Qi, J., Peng, R., Dai, L., Gould, E.A., Tien, P., Gao, G.F. 3.291 X-RAY DIFFRACTION 0.222 0.208 False True IGHV1 IGKV12 Kappa None None None None None 5ywp N M 0 C protein NA jev e protein IMMUNE SYSTEM 11/29/17 JEV-2H4 Fab complex JAPANESE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus japanese encephalitis virus Qiu, X.D., Lei, Y.F., Yang, P., Gao, Q., WANG, N., Cao, L., Yuan, S., Wang, X.X., Xu, Z.K., Rao, Z.H. 4.6 ELECTRON MICROSCOPY NA NA False False IGHV9 IGKV3 Kappa None None None None None 5tbd D G 0 H peptide merozoite surface protein 2 IMMUNE SYSTEM 09/12/16 Crystal Structure of anti-MSP2 Fv fragment (mAb4D11) in complex with 3D7-MSP2 215-222 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum 3d7 Seow, J., Morales, R.A.V., MacRaild, C.A., Bankala, K., Drinkwater, N., Dingjan, T., Jaipuria, G., Wilde, K., Anders, R.F., Atreya, H.S., Christ, D., McGowan, S., Norton, R.S. 2.2 X-RAY DIFFRACTION 0.247 0.207 False True IGHV14 IGKV1 Kappa None None None None None 5xmh D C 0 B protein immunoglobulin gamma-1 heavy chain IMMUNE SYSTEM 05/15/17 Crystal structure of an IgM rheumatoid factor YES8c in complex with IgG1 Fc HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shiroishi, M., Shimokawa, K., Lee, J.M., Kusakabe, M., Ueda, T. 2.8 X-RAY DIFFRACTION 0.272 0.220 False True IGHV1 IGKV3 Kappa 0.00015999999999999999 -5.178506877772148 SPR TBD 7m42 D C 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/19/21 Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, Y., Romero Hernandez, A., Saotome, K., Franklin, M.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 6m87 F E 0 E Hapten 2M9 8-methoxypyrene-1,3,6-trisulfonic acid IMMUNE SYSTEM 08/21/18 Fab 10A6 in complex with MPTS MUS MUSCULUS mus musculus mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.609 X-RAY DIFFRACTION 0.265 0.228 False False IGHV1 IGKV4 Kappa None None None None None 4unt NA H 0 IMMUNE SYSTEM 05/30/14 Induced monomer of the Mcg variable domain HOMO SAPIENS homo sapiens Brumshtein, B., Esswein, S.R., Landau, M., Ryan, C.M., Whitelegge, J.P., Phillips, M.L., Cascio, D., Sawaya, M.R., Eisenberg, D.S. 2.7 X-RAY DIFFRACTION 0.28925 0.24328 False True IGLV2 Lambda None None None None None 7ejx S s 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 04/02/21 Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens Xu, J., Chen, G., Liu, Z., Du, Y. 2.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6jri B NA 0 ANTIVIRAL PROTEIN 04/04/19 Crystal structure of Nanobody VICUGNA PACOS vicugna pacos Mo, X., Li, J., Xu, X., Yuan, A.Y. 3.101 X-RAY DIFFRACTION 0.259 0.235 False True IGHV1 None None None None None 4uta I M 0 A protein envelope glycoprotein e IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX 07/18/14 Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8 HOMO SAPIENS; DENGUE VIRUS 2 homo sapiens homo sapiens dengue virus 2 Rouvinski, A., Guardado-Calvo, P., Barba-Spaeth, G., Duquerroy, S., Vaney, M.C., Rey, F.A. 3.0 X-RAY DIFFRACTION 0.2477 0.2128 False True IGHV3 IGKV3 Kappa None None None None None 6qgy D NA 0 C protein outer membrane protein assembly factor bama MEMBRANE PROTEIN 01/14/19 Crystal structure of E.coli BamA beta-barrel in complex with nanobody B12 ESCHERICHIA COLI O157:H7; LAMA GLAMA lama glama escherichia coli o157 Hartmann, J.-B., Kaur, H., Jakob, R.P., Zahn, M., Zimmermann, I., Seeger, M., Maier, T., Hiller, S. 2.509 X-RAY DIFFRACTION 0.244 0.222 False True IGHV1 None None None None None 7d5b D NA 0 A protein NA beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 09/25/20 BACE2 xaperone complex with N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-5,6-dihydro-2H-1lambda6,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide HOMO SAPIENS homo sapiens homo sapiens Fujimoto, K., Yoshida, S., Tadano, G., Asada, N., Fuchino, K., Suzuki, S., Matsuoka, E., Yamamoto, T., Yamamoto, S., Ando, S., Kanegawa, N., Tonomura, Y., Ito, H., Moechars, D., Rombouts, F.J.R., Gijsen, H.J.M., Kusakabe, K.I. 1.31 X-RAY DIFFRACTION 0.222 0.195 False True IGHV3 NA NA None None None None None 6x9t H L 0 A | B protein | protein NA | NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 | hiv-1 envelope glycoprotein bg505 sosip.664 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 06/03/20 HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in HEK293S cells in complex with RM20A3 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T., Ward, A.B. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 2aab H L 0 immune system 07/13/05 Structural basis of antigen mimicry in a clinically relevant melanoma antigen system MUS MUSCULUS mus musculus mus musculus Chang, C.-C., Hernandez-Guzman, F.G., Luo, W., Wang, X., Ferrone, S., Ghosh, D. 2.5 X-RAY DIFFRACTION 0.297 0.236 False False IGHV5 IGKV3 Kappa None None None None None 7ra3 N NA 0 B protein NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 06/29/21 cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP HOMO SAPIENS; MUS MUSCULUS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens Sun, B., Kobilka, B.K., Sloop, K.W., Feng, D., Kobilka, T.S. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 5t93 NA C 0 IMMUNE SYSTEM 09/09/16 Immunoglobulin light chain variable domain AL-T05 HOMO SAPIENS homo sapiens Ramirez-Alvarado, M., Blancas-Mejia, L.M. 1.9 X-RAY DIFFRACTION 0.223 0.171 False True IGLV1 Lambda None None None None None 1bre NA B 0 IMMUNOGLOBULIN 07/19/95 IMMUNOGLOBULIN LIGHT CHAIN PROTEIN HOMO SAPIENS homo sapiens Schormann, N., Benson, M.D. 2.0 X-RAY DIFFRACTION 0.337 0.218 False True IGKV1 Kappa None None None None None 3chn B M 6 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 7ttm H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 02/01/22 Crystal structure of potent neutralizing antibody 10-40 in complex with Sarbecovirus bat SHC014 receptor-binding domain BAT SARS-LIKE CORONAVIRUS RSSHC014; HOMO SAPIENS homo sapiens homo sapiens bat sars-like coronavirus rsshc014 Reddem, E.R., Shapiro, L. 2.24 X-RAY DIFFRACTION 0.256 0.201 False True IGHV4 IGLV6 Lambda None None None None None 3b2u N O 0 M protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 7lkh H L 0 A protein NA sterol regulatory element-binding protein cleavage-activating protein LIPID BINDING PROTEIN 02/02/21 Chicken Scap D435V L1-L7 domain / Fab complex focused map GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Kober, D.L., Radhakrishnan, A., Goldstein, J.L., Brown, M.S., Clark, L.D., Bai, X.-C., Rosenbaum, D.M. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV14 IGKV10 Kappa None None None None None 4lgp B NA 0 A protein NA ricin HYDROLASE/IMMUNE SYSTEM 06/28/13 Ricin A chain bound to camelid nanobody (VHH1) RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J., Cheung, J., Franklin, M., Burshteyn, F., Cassidy, M., Gary, E., Mantis, N. 2.4 X-RAY DIFFRACTION 0.281 0.225 False True IGHV1 NA NA None None None None None 1vhp A NA 1 IMMUNOGLOBULIN 04/16/96 VH-P8, NMR HOMO SAPIENS homo sapiens Riechmann, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 1pkq G F 0 J protein myelin oligodendrocyte glycoprotein IMMUNE SYSTEM 06/06/03 Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex MUS MUSCULUS; RATTUS NORVEGICUS mus musculus mus musculus rattus norvegicus Breithaupt, C., Schubart, A., Zander, H., Skerra, A., Huber, R., Linington, C., Jacob, U. 3.0 X-RAY DIFFRACTION 0.319 0.250 False True IGHV1 IGKV8 Kappa None None None None None 7s13 H L 0 D protein NA t-cell surface protein tactile IMMUNE SYSTEM 08/31/21 Crystal structure of Fab in complex with mouse CD96 dimer RATTUS; MUS MUSCULUS rattus rattus mus musculus Lee, P.S., Barman, I., Strop, P. 2.12 X-RAY DIFFRACTION 0.265 0.217 False True IGHV2 IGLV3 Lambda None None None None None 7m7j E F 0 B protein NA eryai BIOSYNTHETIC PROTEIN/IMMUNE SYSTEM 03/28/21 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: ""turnstile closed"" state (TE-free) SACCHAROPOLYSPORA ERYTHRAEA; HOMO SAPIENS homo sapiens homo sapiens saccharopolyspora erythraea Cogan, D.P., Zhang, K., Chiu, W., Khosla, C. 4.3 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV2 Kappa None None None None None 3gbm I M 0 D | C protein | protein NA | NA hemagglutinin | hemagglutinin viral protein / immune system 02/20/09 Crystal Structure of Fab CR6261 in Complex with a H5N1 influenza virus hemagglutinin. INFLUENZA A VIRUS (A/VIET NAM/1203/2004(H5N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/viet nam/1203/2004(h5n1)) | influenza a virus (a/viet nam/1203/2004(h5n1)) Ekiert, D.C., Elsliger, M.A., Wilson, I.A. 2.7 X-RAY DIFFRACTION 0.261 0.203 False True IGHV1 IGLV1 Lambda None None None None None 6vn1 H L 0 A protein NA envelope glycoprotein b VIRAL PROTEIN/IMMUNE SYSTEM 01/29/20 A 2.8 Angstrom Cryo-EM Structure of a Glycoprotein B-Neutralizing Antibody Complex Reveals a Critical Domain for Herpesvirus Fusion Initiation HOMO SAPIENS; HUMAN ALPHAHERPESVIRUS 3 homo sapiens homo sapiens human alphaherpesvirus 3 Oliver, S.L. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 3mly I M 0 Q peptide hiv-1 gp120 third variable region (v3) crown IMMUNE SYSTEM 04/18/10 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with a UR29 V3 peptide HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Kong, X.-P. 1.7 X-RAY DIFFRACTION 0.215 0.181 False False IGHV4 IGLV1 Lambda None None None None None 6snc H L 0 P peptide envelope glycoprotein gp160 IMMUNE SYSTEM 08/23/19 crystal structure of LN01 Fab in complex with an HIV-1 gp41 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Caillat, C., Pinto, D., Corti, D., Fenwick, C., Pantaleo, G., Weissenhorn, W. 3.2 X-RAY DIFFRACTION 0.254 0.213 False True IGHV4 IGKV1 Kappa None None None None None 7bua J K 0 C protein genome polyprotein VIRUS 05/13/20 Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0 HOMO SAPIENS; ZIKA VIRUS ZIKV/H. SAPIENS/FRENCHPOLYNESIA/10087PF/2013 homo sapiens homo sapiens zika virus zikv/h.sapiens/frenchpolynesia/10087pf/2013 Zhang, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Lok, S.M. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 6o9i A B 0 C protein ecd IMMUNE SYSTEM 03/13/19 Ternary complex of mouse ECD with Fab1 and Fab2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Min, X., Wang, Z. 2.6 X-RAY DIFFRACTION 0.252 0.196 False True IGHV5 IGKV8 Kappa None None None None None 7mej B NA 0 R protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/06/21 CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb36 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D.J. 3.55 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6n4y E NA 0 B protein metabotropic glutamate receptor 5 MEMBRANE PROTEIN 11/20/18 Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K. 3.262 X-RAY DIFFRACTION 0.251 0.199 False True IGHV1 None None None None None 7lf0 Q O 0 J protein NA arginase-1 HYDROLASE/IMMUNE SYSTEM 01/15/21 Trimeric human Arginase 1 in complex with mAb2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Gomez-Llorente, Y., Scapin, G., Palte, R.L. 3.68 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5cip H L 0 IMMUNE SYSTEM 07/13/15 Crystal Structure of Unbound 4E10 HOMO SAPIENS homo sapiens homo sapiens Caaveiro, J.M.M., Rujas, E., Nieva, J.L., Tsumoto, K. 2.48 X-RAY DIFFRACTION 0.231 0.183 False True IGHV1 IGKV3 Kappa None None None None None 4olv H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 01/25/14 Crystal structure of antibody VRC07-G54F in complex with clade A/E 93TH057 HIV-1 gp120 core HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Kwon, Y.D., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.253 0.203 False True unknown IGKV3 Kappa None None None None None 6awq B C 0 A protein NA sodium-dependent serotonin transporter TRANSPORT PROTEIN 09/06/17 Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Coleman, J.A., Gouaux, E. 4.046 X-RAY DIFFRACTION 0.316 0.269 False True IGHV1 IGKV6 Kappa None None None None None 4lss H L 0 G protein envelope glycoprotein gp120 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 clade A strain KER_2018_11 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.59 X-RAY DIFFRACTION 0.263 0.192 False True unknown IGKV3 Kappa None None None None None 7kf0 H L 0 V protein NA isoform l-vegf206 of vascular endothelial growth factor a IMMUNE SYSTEM 10/13/20 Crystal structure of bH1 Fab variant (CDR H3 loop design 13_0346) in complex with VEGF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Shi, R., Picard, M.-E. 2.32 X-RAY DIFFRACTION 0.246 0.192 False True IGHV3 IGKV1 Kappa None None None None None 6t9d H L 0 C protein NA unknown IMMUNE SYSTEM 10/28/19 Crystal structure of a bispecific DutaFab in complex with human VEGF121 HOMO SAPIENS Kimbung, R., Logan, D.T., Beckmann, R., Jensen, K., Speck, J., Fenn, S., Kettenberger, H. 2.905 X-RAY DIFFRACTION 0.280 0.212 False False IGHV3 IGKV1 Kappa None None None None None 5zv3 H L 0 A peptide peptide from microtubule-associated protein tau IMMUNE SYSTEM 05/09/18 Crystal structure of human anti-tau antibody CBTAU-28.1 in complex with its tau peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Zhang, H., Wilson, I.A. 2.093 X-RAY DIFFRACTION 0.251 0.187 False True IGHV5 IGKV4 Kappa None None None None None 6kn9 E e 0 B protein interleukin-18 receptor accessory protein CYTOKINE 08/05/19 Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv HOMO SAPIENS homo sapiens homo sapiens Wu, D.H., Liu, C.C. 3.302 X-RAY DIFFRACTION 0.277 0.247 True True unknown unknown unknown None None None None None 6qna A B 0 IMMUNE SYSTEM 02/10/19 Structure of bovine anti-RSV hybrid Fab B13HC-B4LC BOS TAURUS bos taurus bos taurus Ren, J., Nettleship, J.E., Harris, G., Mwangi, W., Rhaman, N., Grant, C., Kotecha, A., Fry, E., Charleston, B., Stuart, D.I., Hammond, J., Owens, R.J. 2.62 X-RAY DIFFRACTION 0.250 0.220 False True IGHV1 IGLV1 Lambda None None None None None 7k7y D NA 0 A protein NA botulinum neurotoxin type e ANTITOXIN 09/24/20 Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9 CLOSTRIDIUM BOTULINUM; VICUGNA PACOS vicugna pacos clostridium botulinum Lam, K., Jin, R. 3.6 X-RAY DIFFRACTION 0.288 0.261 False True IGHV1 NA NA None None None None None 3u6r H L 0 IMMUNE SYSTEM 10/12/11 Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 single chain FV fragment 1:7 HOMO SAPIENS homo sapiens homo sapiens Gilmartin, A.A., Lamp, B., Ruemenapf, T., Persson, A.A., Rey, F.A., Krey, T. 2.67 X-RAY DIFFRACTION 0.232 0.190 False True IGHV1 IGKV3 Kappa None None None None None 6qbc H L 0 APOPTOSIS 12/20/18 structure of anti-Mcl1 Fab HOMO SAPIENS homo sapiens homo sapiens Luptak, J. 1.56 X-RAY DIFFRACTION 0.233 0.204 False True IGHV3 IGLV1 Lambda None None None None None 7ora F G 0 R protein NA spike protein s1 VIRAL PROTEIN 06/04/21 Crystal structure of the T478K mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-45 and COVOX-253 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D.I. 2.6 X-RAY DIFFRACTION 0.245 0.204 False True IGHV1 IGKV3 Kappa None None None None None 4jpk H L 0 A protein germline-targeting hiv-1 gp120 engineered outer domain,eod-gt6 IMMUNE SYSTEM/VIRAL PROTEIN 03/19/13 Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1 human immunodeficiency virus 1 Julien, J.-P., Jardine, J., Schief, W.R., Wilson, I.A. 2.4 X-RAY DIFFRACTION 0.263 0.200 False True IGHV1 IGKV3 Kappa 4.4000000000000004e-08 -10.036126204570545 SPR TBD 4rqq H L 0 IMMUNE SYSTEM 11/04/14 Crystal structure of human Fab PGDM1400, a broadly reactive and potent HIV-1 neutralizing antibody HOMO SAPIENS homo sapiens homo sapiens Julien, J.-P., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.253 0.221 False True unknown IGKV2 Kappa None None None None None 6w0h A B 0 C protein NA ph-gated potassium channel kcsa MEMBRANE PROTEIN 02/29/20 Closed-gate KcsA soaked in 5mM KCl/5mM BaCl2 RATTUS NORVEGICUS; STREPTOMYCES LIVIDANS rattus norvegicus rattus norvegicus streptomyces lividans Rohaim, A., Gong, L., Li, J. 2.6 X-RAY DIFFRACTION 0.239 0.194 False True IGHV1 IGKV5 Kappa None None None None None 4k07 NA B 0 IMMUNE SYSTEM 04/03/13 Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant HOMO SAPIENS homo sapiens Thompson, J.R., Berkholz, D.S., Mahlum, E.W., Ramirez-Alvarado, M. 2.83 X-RAY DIFFRACTION 0.236 0.202 False True IGKV1 Kappa None None None None None 1vfa B A 0 IMMUNOGLOBULIN 12/03/93 BOUND WATER MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN-ANTIBODY ASSOCIATION MUS MUSCULUS mus musculus mus musculus Bhat, T.N., Poljak, R.J. 1.8 X-RAY DIFFRACTION unknown 0.158 False True IGHV2 IGKV12 Kappa None None None None None 6x78 B A 0 I peptide NA hiv fusion peptide 512-519 v2 IMMUNE SYSTEM/VIRAL PROTEIN 05/29/20 Vaccine-elicited mouse FP-targeting neutralizing antibody vFP48.03 in complex with HIV fusion peptide (residue 512-519) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus human immunodeficiency virus 1 Xu, K., Kwong, P.D. 2.359 X-RAY DIFFRACTION 0.226 0.178 False True IGHV1 IGKV1 Kappa None None None None None 6ymq C c 0 J protein NA triggering receptor expressed on myeloid cells 2 IMMUNE SYSTEM 04/09/20 TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) HOMO SAPIENS homo sapiens homo sapiens Szykowska, A., Preger, C., Scacioc, A., Mukhopadhyay, S.M.M., McKinley, G., Graslund, S., Wigren, E., Persson, H., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Di Daniel, E., Davis, J.B., Burgess-Brown, N., Bullock, A. 3.07 X-RAY DIFFRACTION 0.288 0.274 True True unknown unknown unknown None None None None None 7we7 J M 0 E protein NA spike glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 5otj B A 0 D protein polcalcin phl p 7 IMMUNE SYSTEM 08/22/17 Monomeric polcalcin (Phl p 7) in complex with two identical allergen-specific antibodies HOMO SAPIENS; PHLEUM PRATENSE homo sapiens homo sapiens phleum pratense Mitropoulou, A.N., Davies, A.M., Beavil, A.J., McDonnell, J.M., Sutton, B.J. 2.35 X-RAY DIFFRACTION 0.235 0.199 False True IGHV1 IGLV1 Lambda 1.7000000000000003e-10 -13.328052315201264 SPR TBD 1a6v J N 0 J Hapten NPC 4-HYDROXY-3-NITROPHENYLACETYL-EPSILON-AMINOCAPROIC ACID ANION IMMUNOGLOBULIN 03/03/98 B1-8 FV FRAGMENT COMPLEXED WITH A (4-HYDROXY-3-NITROPHENYL) ACETATE COMPOUND MUS MUSCULUS mus musculus mus musculus mus musculus Simon, T., Henrick, K., Hirshberg, M., Winter, G. 1.8 X-RAY DIFFRACTION unknown 0.296 False True IGHV1 IGLV1 Lambda None None None None None 6mqm G H 0 I peptide hiv env fusion peptide residue 512-519 IMMUNE SYSTEM 10/10/18 Vaccine-elicited NHP FP-targeting neutralizing antibody DF1W-a.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 3.484 X-RAY DIFFRACTION 0.246 0.200 False True IGHV4 IGKV2 Kappa None None None None None 6mxt N NA 0 A protein endolysin, beta-2 adrenergic receptor chimera SIGNALING PROTEIN/HORMONE 10/31/18 Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71 ENTEROBACTERIA PHAGE T4; HOMO SAPIENS; LAMA GLAMA lama glama enterobacteria phage t4, homo sapiens Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K. 2.95934 X-RAY DIFFRACTION 0.245 0.205 False True IGHV1 None None None None None 7f7h A B 0 E protein NA spike glycoprotein s1 VIRAL PROTEIN/IMMUNE SYSTEM 06/29/21 SARS-CoV-2 S protein RBD in complex with A8-1 Fab HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dou, Y., Wang, X., Wang, K., Liu, P., Lu, B. 3.19 X-RAY DIFFRACTION 0.275 0.205 False True IGHV3 IGKV1 Kappa None None None None None 3ri5 F N 0 B protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.4 X-RAY DIFFRACTION 0.248 0.232 False True IGHV1 IGLV1 Lambda None None None None None 4r90 H L 0 Immune System 09/03/14 Anti CD70 Llama glama Fab 27B3 LLAMA GLAMA lama glama lama glama Klarenbeek, A., El Mazouari, K., Desmyter, A., Blanchetot, C., Hultberg, A., Roovers, R.C., Cambillau, C., Spinelli, S., Del-Favero, J., Verrips, T., de Haard, H., Achour, I. 1.746 X-RAY DIFFRACTION 0.185 0.163 False True IGHV3 IGLV8 Lambda None None None None None 7sl9 B NA 0 A protein NA sodium-coupled monocarboxylate transporter 1 MEMBRANE PROTEIN 10/23/21 CryoEM structure of SMCT1 HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens Qu, Q., Han, L., Panova, O., Feng, L., Skiniotis, G. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5tbd A B 0 C peptide merozoite surface protein 2 IMMUNE SYSTEM 09/12/16 Crystal Structure of anti-MSP2 Fv fragment (mAb4D11) in complex with 3D7-MSP2 215-222 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum 3d7 Seow, J., Morales, R.A.V., MacRaild, C.A., Bankala, K., Drinkwater, N., Dingjan, T., Jaipuria, G., Wilde, K., Anders, R.F., Atreya, H.S., Christ, D., McGowan, S., Norton, R.S. 2.2 X-RAY DIFFRACTION 0.247 0.207 False True IGHV14 IGKV1 Kappa None None None None None 6uda C D 0 A protein ch505.n279k.g458y.sosip.664 gp120 VIRAL PROTEIN/Immune System 09/19/19 Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Henderson, R., Acharya, P. 4.2 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 5feh F E 0 IMMUNE SYSTEM 12/17/15 Crystal structure of PCT64_35B, a broadly neutralizing anti-HIV antibody HOMO SAPIENS homo sapiens homo sapiens Murrell, S., Wilson, I.A. 3.1 X-RAY DIFFRACTION 0.279 0.259 False True IGHV3 IGKV3 Kappa None None None None None 2hrp N M 0 Q peptide hiv-1 protease peptide COMPLEX (IMMUNOGLOBULIN/PEPTIDE) 12/27/96 ANTIGEN-ANTIBODY COMPLEX MUS MUSCULUS mus musculus mus musculus Lescar, J., Bentley, G.A. 2.2 X-RAY DIFFRACTION 0.289 0.198 False False IGHV5 IGKV3 Kappa 5.00e-09 -11.32 SPR 9150407 6qf9 A a 0 APOPTOSIS 01/09/19 Structure of an anti-Mcl1 scFv HOMO SAPIENS homo sapiens Luptak, J. 1.43 X-RAY DIFFRACTION 0.216 0.185 True True unknown unknown unknown None None None None None 7rtp NA A 0 B Hapten NY9 N-{2-[7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl]ethyl}-N'-[(pyridin-3-yl)methyl]urea IMMUNE SYSTEM 08/13/21 Structure of full-length human lambda-6A light chain JTO in complex with urea stabilizer 20 [1-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-3-(pyridin-3-ylmethyl)urea] HOMO SAPIENS homo sapiens homo sapiens Yan, N.L., Wilson, I.A., Kelly, J.W. 2.09 X-RAY DIFFRACTION 0.238 0.179 False True NA IGLV6 Lambda None None None None None 3ezj F NA 0 E protein general secretion pathway protein gspd PROTEIN TRANSPORT 10/22/08 Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Korotkov, K.V, Pardon, E., Steyaert, J., Hol, W.G. 2.8 X-RAY DIFFRACTION 0.239 0.192 False True IGHV1 None None None None None 6bkc H L 0 E protein polyprotein IMMUNE SYSTEM 11/08/17 Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3B HOMO SAPIENS; RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 homo sapiens homo sapiens recombinant hepatitis c virus hk6a/jfh-1 Tzarum, N., Wilson, I.A., Law, M. 2.6 X-RAY DIFFRACTION 0.276 0.231 False True IGHV1 IGKV3 Kappa 8.000000000000001e-10 -12.410405717143199 BLI TBD 6yor H L 0 E protein rbd VIRAL PROTEIN 04/15/20 Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab SEVERE ACUTE RESPIRATORY SYNDROME-RELATED CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome-relatedcoronavirus Huo, J., Zhao, Y., Ren, J., Zhou, D., Duyvesteyn, H.M.E., Carrique, L., Malinauskas, T., Ruza, R.R., Shah, P.N.M., Fry, E.E., Owens, R., Stuart, D.I. 3.9 ELECTRON MICROSCOPY False True IGHV5 IGKV4 Kappa None None None None None 4pb9 H L 0 IMMUNE SYSTEM 04/11/14 Structure of the Fab fragment of the anti-Francisella tularensis GroEL antibody Ab64 MUS MUSCULUS mus musculus mus musculus Lu, Z., Rynkiewicz, M.J., Seaton, B.A., Sharon, J. 2.6 X-RAY DIFFRACTION 0.240 0.185 False False IGHV1 IGKV2 Kappa None None None None None 6nb7 D E 0 B protein spike glycoprotein VIRUS 12/06/18 SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2) SARS CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens sars coronavirus Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, S., Quispe, J., Cameroni, E., Gopal, R., Mian, D., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 4.5 ELECTRON MICROSCOPY False True IGHV3 IGKV2 Kappa None None None None None 6nm6 U V 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 01/10/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to N6 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.2 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.739 X-RAY DIFFRACTION 0.288 0.240 False True unknown unknown unknown None None None None None 5f3b A B 0 C protein growth/differentiation factor 8 Signaling Protein/Immune System 12/02/15 Structure of myostatin in complex with chimeric RK35 antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Parris, K.D., Mosyak, L. 1.76 X-RAY DIFFRACTION 0.206 0.179 False True IGHV5 IGKV6 Kappa 3e-12 -15.720019221239749 SPR TBD 7rmg N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short, with certain residues mutated to match guanine nucleotide-binding protein g(q) subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN/MEMBRANE PROTEIN 07/27/21 Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70 HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Harris, J.A., Faust, B., Gondin, A.B., Daemgen, M.A., Suomivuori, C.M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D., Manglik, A. 3 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7kmk I M 0 B protein NA spike glycoprotein Viral protein/Immune System 11/03/20 cryo-EM structure of SARS-CoV-2 spike in complex with Fab 15033-7, two RBDs bound SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Li, Z., Rini, J.M. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 3chn D N 1 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 5bk5 F E 0 IMMUNE SYSTEM 09/12/17 Crystal structure of the anti-circumsporozoite protein 663 germline antibody HOMO SAPIENS homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 3.0 X-RAY DIFFRACTION 0.314 0.257 False True IGHV3 IGKV2 Kappa None None None None None 5fuc V NA 0 D | A protein | protein NA | NA interleukin-6 receptor subunit alpha, interleukin-6receptor | interleukin-6 IMMUNE SYSTEM 01/25/16 Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies HOMO SAPIENS; CAMELUS DROMEDARIUS camelus dromedarius homo sapiens | homo sapiens Adams, R., Griffin, R., Doyle, C., Ettorre, A. 2.7 X-RAY DIFFRACTION 0.287 0.231 False True IGHV1 NA NA None None None None None 2dqc H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 05/25/06 Crystal structure of hyhel-10 FV mutant(Hy33f) complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Shiroishi, M., Kondo, H., Tsumoto, K., Kumagai, I. 1.8 X-RAY DIFFRACTION 0.223 0.190 False True IGHV3 IGKV5 Kappa None None None None None 1xf3 H L 0 IMMUNE SYSTEM 09/13/04 Structure of ligand-free Fab DNA-1 in space group P65 MUS MUSCULUS mus musculus mus musculus Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J. 2.3 X-RAY DIFFRACTION 0.243 0.208 False True IGHV1 IGKV12 Kappa None None None None None 7oau F NA 0 E protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody C5 bound to Kent variant RBD (N501Y) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 1.65 X-RAY DIFFRACTION 0.199 0.175 False False IGHV1 NA NA None None None None None 1orq B A 0 C protein potassium channel MEMBRANE PROTEIN 03/14/03 X-ray structure of a voltage-dependent potassium channel in complex with an Fab AEROPYRUM PERNIX; MUS MUSCULUS mus musculus mus musculus aeropyrum pernix Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. 3.2 X-RAY DIFFRACTION 0.298 0.253 False False IGHV3 IGKV4 Kappa None None None None None 6mu8 H L 0 G protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/22/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-386150 in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.993 X-RAY DIFFRACTION 0.259 0.219 False True IGHV4 unknown unknown None None None None None 7pc2 Q R 0 A protein NA gp120, bg505 sosip.664 t332n VIRAL PROTEIN 08/03/21 HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117. HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS homo sapiens homo sapiens human immunodeficiency virus Fernandez, I., Bontems, F., Pehau-Arnaudet, G., Rey, F. 2.8 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 7fjs H L 0 E protein NA spike protein s1 IMMUNE SYSTEM/VIRAL PROTEIN 08/04/21 Crystal structure of T6 Fab bound to theSARS-CoV-2 RBD of B.1.351 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhang, L., Zhang, S., Liang, Q. 2.9 X-RAY DIFFRACTION 0.285 0.217 False True IGHV1 IGKV8 Kappa None None None None None 2i5y H L 0 G protein exterior membrane glycoprotein(gp120) VIRAL PROTEIN/IMMUNE SYSTEM 08/26/06 Crystal structure of CD4M47, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 GP120 envelope glycoprotein and anti-HIV-1 antibody 17B HUMAN IMMUNODEFICIENCY VIRUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus Huang, C.-C., Kwong, P.D. 2.2 X-RAY DIFFRACTION 0.273 0.214 False True IGHV1 IGKV3 Kappa 2.7e-09 -11.689711339052632 SPR TBD 1xgp B A 0 C protein lysozyme c IMMUNE SYSTEM 09/17/04 Structure for antibody HyHEL-63 Y33A mutant complexed with hen egg lysozyme MUS MUSCULUS; GALLUS GALLUS mus musculus mus musculus gallus gallus Li, Y., Mariuzza, R.A. 2.1 X-RAY DIFFRACTION 0.271 0.215 False True IGHV3 IGKV5 Kappa None None None None None 7zfa X Y 0 C protein NA spike protein s1 VIRAL PROTEIN 04/01/22 SARS-CoV-2 Omicron RBD in complex with Omi-6 and COVOX-150 Fabs Homo sapiens; Severe acute respiratory syndrome coronavirus 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Huo, J., Ren, J., Stuart, D.I. 4.24 X-RAY DIFFRACTION 0.272 0.237 False True IGHV3 IGKV1 Kappa None None None None None 7u8c H L 0 2 peptide NA unknown IMMUNE SYSTEM 03/08/22 Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Zhan, J., Esser, L., Xia, D. 1.74 X-RAY DIFFRACTION 0.238 0.204 False True IGHV1 IGLV1 Lambda None None None None None 7byr H L 0 B protein sars-cov-2 spike glycoprotein VIRAL PROTEIN 06/10/20 BD23-Fab in complex with the S ectodomain trimer SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhu, Q., Wang, G., Xiao, J. 3.84 ELECTRON MICROSCOPY False True IGHV7 IGKV1 Kappa None None None None None 2w0l NA D 0 IMMUNE SYSTEM 08/19/08 CRYSTAL STRUCTURE OF THE MUTANT H8P FROM THE RECOMBINANT VARIABLE DOMAIN 6JAL2 HOMO SAPIENS homo sapiens RUDINO-PINERA, E., GONZALEZRUBIO-GARRIDO, P., HORJALES, E. 2.2 X-RAY DIFFRACTION 0.245 0.206 False False IGLV6 Lambda None None None None None 6ba5 B A 0 M protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/12/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.62 X-RAY DIFFRACTION 0.214 0.194 False True IGHV1 IGKV1 Kappa None None None None None 3tt3 H L 0 A protein leucine transporter leut TRANSPORT PROTEIN 09/13/11 Crystal Structure of LeuT in the inward-open conformation in complex with Fab AQUIFEX AEOLICUS; MUS MUSCULUS mus musculus mus musculus aquifex aeolicus Krishnamurthy, H., Gouaux, E. 3.22 X-RAY DIFFRACTION 0.300 0.257 False True IGHV1 IGKV3 Kappa None None None None None 7lka H L 0 NA NA NA NA IMMUNE SYSTEM 02/02/21 Crystal structure of SARS-CoV-2 RBD-targeting antibody COV107-23 HOMO SAPIENS homo sapiens homo sapiens Yuan, M., Zhu, X., Wilson, I.A., Wu, N.C. 1.981 X-RAY DIFFRACTION 0.264 0.215 False True IGHV3 IGKV1 Kappa None None None None None 3stb A NA 0 D protein mp18 rna editing complex protein RNA BINDING PROTEIN/IMMUNE SYSTEM 07/09/11 A complex of two editosome proteins and two nanobodies LAMA GLAMA; TRYPANOSOMA BRUCEI lama trypanosoma brucei Park, Y.-J., Hol, W. 2.5 X-RAY DIFFRACTION 0.234 0.199 False True IGHV1 None None None None None 6fab H L 0 IMMUNOGLOBULIN 01/17/91 THREE-DIMENSIONAL STRUCTURE OF MURINE ANTI-P-AZOPHENYLARSONATE FAB 36-71. 1. X-RAY CRYSTALLOGRAPHY, SITE-DIRECTED MUTAGENESIS, AND MODELING OF THE COMPLEX WITH HAPTEN MUS MUSCULUS mus musculus mus musculus Strong, R.K., Rose, D.R., Petsko, G.A., Sharon, J., Margolies, M.N. 1.9 X-RAY DIFFRACTION unknown unknown False True IGHV1 IGKV10 Kappa None None None None None 3dwt E NA 0 IMMUNE SYSTEM 07/23/08 Structure of CabBCII-10 nanobody CAMELUS DROMEDARIUS camelus dromedarius Vincke, C., Loris, R., Muyldermans, S., Conrath, K. 2.9 X-RAY DIFFRACTION 0.305 0.245 False True IGHV1 None None None None None 2qql H L 0 A protein neuropilin-2 SIGNALING PROTEIN 07/26/07 Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Appleton, B.A., Wiesmann, C. 3.1 X-RAY DIFFRACTION 0.232 0.188 False True IGHV3 IGKV1 Kappa None None None None None 2j88 H L 0 A protein hyalurononglucosaminidase HYDROLASE 10/23/06 Hyaluronidase in complex with a monoclonal IgG Fab fragment APIS MELLIFERA; SYNTHETIC CONSTRUCT mus musculus mus musculus apis mellifera Padavattan, S., Schirmer, T., Housley, Z.Markovic- 2.6 X-RAY DIFFRACTION 0.247 0.210 False False IGHV8 IGKV12 Kappa None None None None None 7w53 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/21 Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens You, C., Xu, H.E., Jiang, Y. 3.2 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 1a4k B A 0 B Hapten FRA [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID IMMUNOGLOBULIN 01/30/98 DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE MUS MUSCULUS mus musculus mus musculus mus musculus Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C. 2.4 X-RAY DIFFRACTION 0.291 0.211 False True IGHV9 IGKV1 Kappa 1.00e-08 -10.91 Other 25 9506942 7r8o O P 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/26/21 Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C548 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 DeLaitsch, A.T., Barnes, C.O., Bjorkman, P.J. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV9 Lambda None None None None None 7lj5 G F 0 B protein NA isoform 2 of potassium channel subfamily k member 4 METAL TRANSPORT/Immune System 01/28/21 Human TRAAK K+ channel FHIEG mutant A198E in a K+ bound conductive conformation HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Rietmeijer, R.A., Brohawn, S.G. 2.26 X-RAY DIFFRACTION 0.252 0.220 False True IGHV1 IGKV4 Kappa None None None None None 5wko C D 0 X | U protein | protein NA | NA hemagglutinin | hemagglutinin ANTIVIRAL PROTEIN 07/25/17 Crystal structure of antibody 27F3 recognizing the HA from A/California/04/2009 (H1N1) influenza virus HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus | influenza a virus Wilson, A., Lang, S., Zhu, X. 3.492 X-RAY DIFFRACTION 0.268 0.246 False True IGHV1 IGKV3 Kappa None None None None None 4uim A B 0 03/30/15 crystal structure of quinine-dependent Fab 314.3 MUS MUSCULUS mus musculus mus musculus Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. 2.7 X-RAY DIFFRACTION 0.2596 0.2215 False False IGHV1 IGKV10 Kappa None None None None None 3r06 B A 0 IMMUNE SYSTEM 03/07/11 Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius Shore, D.A., Zhu, X., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.191 False True IGHV5 IGKV14 Kappa None None None None None 2nr6 D C 0 A protein aspartic protease bla g 2 HYDROLASE/IMMUNE SYSTEM 11/01/06 Crystal structure of the complex of antibody and the allergen Bla g 2 BLATTELLA GERMANICA; MUS MUSCULUS mus musculus mus musculus blattella germanica Li, M., Gustchina, A., Wlodawer, A., Pomes, A., Wunschmann, S. 2.81 X-RAY DIFFRACTION 0.281 0.232 False True IGHV14 IGKV6 Kappa None None None None None 5vkk H L 0 IMMUNE SYSTEM 04/21/17 Crystal structure of Fab fragment of anti-CD22 Epratuzumab HOMO SAPIENS, MUS MUSCULUS; HOMO SAPIENS homo sapiens, mus musculus, homo sapiens homo sapiens, mus musculus, homo sapiens Sicard, T., Ereno Orbea, J., Julien, J.-P. 2.014 X-RAY DIFFRACTION 0.237 0.212 False True IGHV1 IGKV8 Kappa None None None None None 5hi4 H L 0 A protein interleukin-17a IMMUNE SYSTEM/INHIBITOR 01/11/16 Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens homo sapiens Liu, S. 1.8 X-RAY DIFFRACTION 0.224 0.200 False True IGHV3 IGLV6 Lambda None None None None None 7m42 B A 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/19/21 Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, Y., Romero Hernandez, A., Saotome, K., Franklin, M.C. 3.3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6mek I G 0 A protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HEPACIVIRUS C; HOMO SAPIENS homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.290 0.223 False True IGHV1 IGLV1 Lambda None None None None None 6f2g B NA 0 A protein putative amino acid/polyamine transport protein TRANSPORT PROTEIN 11/24/17 Bacterial asc transporter crystal structure in open to in conformation CARNOBACTERIUM SP. AT7; LAMA GLAMA lama glama carnobacterium sp. at7 Fort, J., Errasti-Murugarren, E., Carpena, X., Palacin, M., Fita, I. 2.92 X-RAY DIFFRACTION 0.261 0.238 False True IGHV1 None None None None None 7jhg H L 0 A protein NA 5'-amp-activated protein kinase catalytic subunit alpha-1 TRANSFERASE/IMMUNE SYSTEM 07/20/20 Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody HOMO SAPIENS; ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Yan, Y., Murkherjee, S., Zhou, X.E., Xu, T.H., Xu, H.E., Kossiakoff, A.A., Melcher, K. 3.47 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5imk B NA 0 A protein v-set and immunoglobulin domain-containing protein 4 IMMUNE SYSTEM 03/06/16 Nanobody targeting human Vsig4 in Spacegroup C2 HOMO SAPIENS; CAMELIDAE camelidae homo sapiens Wen, Y. 1.227 X-RAY DIFFRACTION 0.185 0.172 False True IGHV1 8.5e-07 -8.281754349880028 ITC TBD 6tyl J NA 0 F protein resistance to inhibitors of cholinesterase 8 homolog a (c.elegans) SIGNALING PROTEIN 08/09/19 Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex RATTUS NORVEGICUS; LAMA GLAMA lama glama rattus norvegicus Mou, T.C., McClelland, L., Yates-Hansen, C., Sprang, S.R. 3.3 X-RAY DIFFRACTION 0.287 0.248 False True IGHV1 None None None None None 7oay J NA 0 I protein NA unknown ANTIVIRAL PROTEIN 04/20/21 Nanobody F2 bound to RBD SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA Naismith, J.H., Mikolajek, H. 2.34 X-RAY DIFFRACTION 0.228 0.192 False False IGHV1 NA NA None None None None None 6obg D NA 0 B protein ricin a chain TOXIN 04/01/20 Ricin A chain bound to VHH antibody V8E6 RICINUS COMMUNIS; VICUGNA PACOS vicugna pacos ricinus communis Rudolph, M.J. 1.996 X-RAY DIFFRACTION 0.218 0.189 False True IGHV1 None None None None None 1uac H L 0 Y protein lysozyme c IMMUNE SYSTEM/HYDROLASE 03/08/03 Crystal Structure of HYHEL-10 FV MUTANT SFSF Complexed with TURKEY WHITE LYSOZYME MUS MUSCULUS; MELEAGRIS GALLOPAVO mus musculus mus musculus meleagris gallopavo Kumagai, I., Nishimiya, Y., Kondo, H., Tsumoto, K. 1.7 X-RAY DIFFRACTION unknown unknown False True IGHV3 IGKV5 Kappa None None None None None 7kra I J 0 A protein NA er membrane protein complex subunit 1 MEMBRANE PROTEIN/IMMUNE SYSTEM 11/19/20 Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs HOMO SAPIENS; SACCHAROMYCES CEREVISIAE homo sapiens homo sapiens saccharomyces cerevisiae Miller-Vedam, L.E., Schirle Oakdale, N.S., Braeuning, B., Boydston, E.A., Sevillano, N., Popova, K.D., Bonnar, J.L., Shurtleff, M.J., Prabu, J.R., Stroud, R.M., Craik, C.S., Schulman, B.A., Weissman, J.S., Frost, A. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV2 Kappa None None None None None 6eqc E e 0 B protein hexon protein VIRAL PROTEIN 10/12/17 Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon MUS MUSCULUS; HUMAN ADENOVIRUS 5 mus musculus human adenovirus 5 Schmid, M., Ernst, P., Honegger, A., Suomalainen, M., Zimmermann, M., Braun, L., Stauffer, S., Thom, C., Dreier, B., Eibauer, M., Kipar, A., Vogel, V., Greber, U.F., Medalia, O., Plueckthun, A. 7.4 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 5w1k O N 0 P protein pre-glycoprotein polyprotein gp complex VIRAL PROTEIN/IMMUNE SYSTEM 06/03/17 JUNV GP1 CR1-10 Fab CR1-28 Fab complex HOMO SAPIENS; JUNIN MAMMARENAVIRUS homo sapiens homo sapiens junin mammarenavirus Raymond, D.D., Clark, L.E., Abraham, J. 3.99 X-RAY DIFFRACTION 0.288 0.237 False True IGHV4 IGKV3 Kappa None None None None None 5ihl I NA 0 H protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 02/29/16 STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB HOMO SAPIENS homo sapiens homo sapiens Sheriff, S. 3.3 X-RAY DIFFRACTION 0.298 0.268 False True IGHV3 None None None None None 5x2n H L 0 A | B protein | protein NA | NA taste receptor, type 1, member 2a | taste receptor, type 1, member 3 SIGNALING PROTEIN/IMMUNE SYSTEM 02/02/17 Crystal structure of the medaka fish taste receptor T1r2a-T1r3 ligand binding domains in complex with L-alanine ORYZIAS LATIPES; MUS MUSCULUS mus musculus mus musculus oryzias latipes | oryzias latipes Nuemket, N., Yasui, N., Atsumi, N., Yamashita, A. 2.2 X-RAY DIFFRACTION 0.244 0.195 False True IGHV1 IGKV3 Kappa None None None None None 4wht Q R 0 q peptide unknown VIRAL PROTEIN 09/23/14 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form HEPATITIS C VIRUS; RATTUS NORVEGICUS rattus norvegicus rattus norvegicus hepatitis c virus Krey, T., Rey, F.A. 2.22 X-RAY DIFFRACTION 0.243 0.209 False True IGHV5 IGKV2 Kappa 7.900000000000001e-09 -11.053614350904786 Unknown TBD 3eo0 B A 0 IMMUNE SYSTEM 09/26/08 Structure of the Transforming Growth Factor-Beta Neutralizing Antibody GC-1008 MUS MUSCULUS mus musculus mus musculus Gruetter, C., Gruetter, M.G. 1.75 X-RAY DIFFRACTION 0.201 0.182 False True IGHV1 IGKV8 Kappa None None None None None 3cfk K J 0 IMMUNE SYSTEM 03/04/08 Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Wilson, I.A. 2.6 X-RAY DIFFRACTION 0.244 0.221 False True IGHV4 IGLV1 Lambda None None None None None 5utz J K 0 I protein interleukin-2 CYTOKINE/IMMUNE SYSTEM 02/15/17 Human IL-2/Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Jude, K.M., Garcia, K.C. 2.747 X-RAY DIFFRACTION 0.248 0.193 False True IGHV4 IGLV6 Lambda 1.879e-09 -11.904493814008964 SPR TBD 7uem H L 0 A carbohydrate GAL BETA-D-GALACTOSE IMMUNE SYSTEM 03/22/22 Genomic and structural basis for the human anti-alpha-galactosyl antibody response Homo sapiens homo sapiens homo sapiens Langley, D.B., Christ, D. 2.314 X-RAY DIFFRACTION 0.231 0.189 False True IGHV3 IGKV2 Kappa None None None None None 5ojm K NA 0 A protein human gabaa receptor chimera beta3-alpha5,gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit alpha-5 MEMBRANE PROTEIN 07/21/17 Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 SYNTHETIC CONSTRUCT; HOMO SAPIENS; LAMA GLAMA lama glama synthetic construct, homo sapiens Miller, P.S., Scott, S., Masiulis, S., De Colibus, L., Pardon, E., Steyaert, J., Aricescu, A.R. 3.3 X-RAY DIFFRACTION 0.250 0.234 False True IGHV1 None None None None None 7k3a J I 0 C | D protein | protein NA | NA hemagglutinin | hemagglutinin VIRAL PROTEIN 09/10/20 Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation B, fusion peptide release INFLUENZA A VIRUS (STRAIN A/HONG KONG/1/1968 H3N2); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (strain a/hong kong/1/1968h3n2) | influenza a virus (strain a/hong kong/1/1968h3n2) Gui, M., Gao, J., Xiang, Y. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 43ca H G 0 G Hapten NPO P-NITROPHENOL IMMUNOGLOBULIN 03/10/99 CRYSTALLOGRAPHIC STRUCTURE OF THE ESTEROLYTIC AND AMIDOLYTIC 43C9 ANTIBODY WITH BOUND P-NITROPHENOL MUS MUSCULUS mus musculus mus musculus mus musculus Thayer, M.M., Getzoff, E.D., Roberts, V.A. 2.3 X-RAY DIFFRACTION 0.259 0.206 False True IGHV2 IGKV8 Kappa None None None None None 5nbi H L 0 IMMUNE SYSTEM 03/02/17 Principles for computational design of antibodies ESCHERICHIA COLI Dym, O., Fleishman, S.J. 2.1 X-RAY DIFFRACTION 0.258 0.218 False True IGHV6 IGKV3 Kappa None None None None None 5um8 H L 0 G protein glycoprotein gp120 Viral Protein/Immune System 01/26/17 Crystal structure of HIV-1 envelope trimer 16055 NFL TF CC T(569)G in complex with Fabs 35022 and PGT124 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Garces, F., Stanfield, R.L., Wilson, I.A. 3.935 X-RAY DIFFRACTION 0.329 0.260 False True IGHV4 unknown unknown None None None None None 4g6a H L 0 A peptide e2 peptide IMMUNE SYSTEM 07/18/12 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens hepatitis c virus Kong, L., Wilson, I.A., Law, M. 2.501 X-RAY DIFFRACTION 0.220 0.178 False True IGHV3 IGKV3 Kappa None None None None None 6f2w B NA 0 A protein putative amino acid/polyamine transport protein TRANSPORT PROTEIN 11/27/17 Bacterial asc transporter crystal structure in open to in conformation CARNOBACTERIUM SP. AT7; LAMA GLAMA lama glama carnobacterium sp. at7 Fort, J., Errasti-Murugarren, E., Carpena, X., Palacin, M., Fita, I. 3.4 X-RAY DIFFRACTION 0.268 0.230 False True IGHV1 None None None None None 5yy5 C D 0 B protein mers-cov rbd VIRAL PROTEIN 12/08/17 Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; HOMO SAPIENS homo sapiens homo sapiens middle east respiratory syndrome coronavirus Zhang, S.Y., Wang, P.F., Zhou, P.P., Wang, X.Q., Zhang, L.Q. 2.8 X-RAY DIFFRACTION 0.279 0.246 False True IGHV3 IGLV1 Lambda None None None None None 5ovw H NA 0 A protein vitamin b12-binding protein TRANSPORT PROTEIN 08/30/17 Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Mireku, S.A., Sauer, M.M., Glockshuber, R., Locher, K.P. 2.653 X-RAY DIFFRACTION 0.259 0.223 False True IGHV1 None None None None None 6vuo B b 0 NA NA NA NA PROTEIN BINDING 02/16/20 Reverse Transcriptase Diabody with S82bC/R83T Mutation HOMO SAPIENS homo sapiens Chelsy, C., Arnold, E. 1.449 X-RAY DIFFRACTION 0.172 0.141 True True unknown unknown unknown None None None None None 6apo A NA 0 IMMUNE SYSTEM 08/17/17 Anti-Marburgvirus Nucleoprotein Single Domain Antibody A LAMA GLAMA lama glama Taylor, A.B., Garza, J.A. 1.168 X-RAY DIFFRACTION 0.173 0.148 False True unknown unknown unknown None None None None None 1oar K O 0 K Hapten AZN ALIZARIN RED IMMUNE SYSTEM 01/21/03 Fv IgE SPE-7 in complex with Alizarin Red RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.23 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 IGLV1 Lambda 4.00e-08 Other 20 12610298 6e64 H L 0 IMMUNE SYSTEM 07/23/18 Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody 85RF45.1 RATTUS NORVEGICUS rattus norvegicus rattus norvegicus Kundu, P., Semesi, A., Julien, J.P. 3.15 X-RAY DIFFRACTION 0.279 0.246 False True IGHV5 IGLV3 Lambda None None None None None 2kqm NA A 2 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6z2l C B 0 A protein NA surface protein p113 CELL INVASION 05/16/20 Structure of Plasmodium falciparum P113 bound to antibody P3.2 PLASMODIUM FALCIPARUM 3D7; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum 3d7 Campeotto, I., Higgins, K.M. 1.95 X-RAY DIFFRACTION 0.226 0.205 False True IGHV1 IGKV10 Kappa None None None None None 6a4k K O 0 D protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 06/20/18 Human antibody 32D6 Fab in complex with H1N1 influenza A virus HA1 INFLUENZA A VIRUS (A/CALIFORNIA/7/2009(H1N1)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/7/2009(h1n1)) Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 3.15 X-RAY DIFFRACTION 0.233 0.175 False True IGHV4 IGLV4 Lambda None None None None None 6wgb A B 0 NA NA NA NA IMMUNE SYSTEM 04/05/20 Crystal structure of the fab portion of dupilumab HOMO SAPIENS homo sapiens homo sapiens Druzina, Z., Atwell, S., Pustilnik, A., Antonysamy, S., Ho, C., Lieu, R., Hendle, J., Benach, J., Wang, J. 1.99 X-RAY DIFFRACTION 0.299 0.243 False True IGHV3 IGKV2 Kappa None None None None None 6o3g A B 0 I peptide meper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41). HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 3.645 X-RAY DIFFRACTION 0.289 0.260 False True IGHV1 IGKV3 Kappa None None None None None 1rua H L 0 immune system 12/11/03 Crystal structure (B) of u.v.-irradiated cationic cyclization antibody 4C6 fab at pH 4.6 with a data set collected at SSRL beamline 11-1. MUS MUSCULUS mus musculus mus musculus Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A. 1.75 X-RAY DIFFRACTION unknown unknown False False IGHV3 IGKV1 Kappa None None None None None 6mub H L 0 H carbohydrate BMA polysaccharide IMMUNE SYSTEM 10/22/18 Anti-HIV-1 Fab 2G12 + Man5 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wilson, I.A., Calarese, D.A., Stanfield, R.L. 2.503 X-RAY DIFFRACTION 0.280 0.245 False True unknown IGKV1 Kappa 1e-07 -9.54970862587178 Unknown TBD 5a7x L K 0 I protein hiv-1 yu2 gp120 VIRAL PROTEIN 07/10/15 negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Scharf, L., Wang, H., Gao, H., Chen, S., McDowall, A., Bjorkman, P. 17.0 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 7wrl A B 0 R protein NA spike protein s1 VIRAL PROTEIN 01/27/22 Local structure of BD55-1239 Fab and SARS-COV2 Omicron RBD complex SARS coronavirus B012 sars coronavirus b012 sars coronavirus b012 sars coronavirus b012 Zhang, Z.Z., Xiao, J.J. 0 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 6mqe H L 0 C peptide hiv fusion peptide IMMUNE SYSTEM 10/09/18 Vaccine-elicited NHP FP-targeting neutralizing antibody DFPH-a.15 in complex with FP (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.459 X-RAY DIFFRACTION 0.245 0.192 False True IGHV4 IGKV1 Kappa None None None None None 3ngb H L 0 G protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 06/11/10 Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Kwong, P.D. 2.68 X-RAY DIFFRACTION 0.256 0.197 False True IGHV1 IGKV3 Kappa 7.70e-09 -10.88 SPR 20 20616231 5wob M N 0 C protein insulin HYDROLASE 08/01/17 Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin HOMO SAPIENS; MUS MUSCULOIDES mus musculoides mus musculoides homo sapiens McCord, L.A., Liang, W.G., Farcasanu, M., Wang, A.G., Koide, S., Tang, W.J. 3.95 X-RAY DIFFRACTION 0.291 0.243 False True IGHV3 IGKV1 Kappa None None None None None 7s11 I M 0 D protein NA t-cell surface protein tactile IMMUNE SYSTEM 08/31/21 Crystal structure of Fab in complex with mouse CD96 monomer MUS MUSCULUS; RATTUS rattus rattus mus musculus Lee, P.S., Chau, B., Strop, P. 2.58 X-RAY DIFFRACTION 0.279 0.226 False True IGHV2 IGLV1 Lambda None None None None None 4ffz H L 0 A protein envelope protein e IMMUNE SYSTEM/VIRAL PROTEIN 06/01/12 Crystal Structure of DENV1-E111 fab fragment bound to DENV-1 DIII (Western Pacific-74 strain). DENGUE VIRUS 1; MUS MUSCULUS mus musculus mus musculus dengue virus 1 Austin, S.K., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 3.8 X-RAY DIFFRACTION 0.278 0.237 False False IGHV1 IGKV3 Kappa 4.16e-07 -8.705114208770938 SPR TBD 4f58 I M 0 IMMUNE SYSTEM 05/12/12 Fab structure of a neutralizing antibody L3 from an early subtype A HIV-1 infected patient HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.488 X-RAY DIFFRACTION 0.256 0.208 False False IGHV3 IGLV2 Lambda None None None None None 6p60 G H 0 I peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 06/03/20 Vaccine-elicited NHP FP-targeting neutralizing antibody A12V163-a.02 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Liu, K., Kwong, P.D. 2.498 X-RAY DIFFRACTION 0.209 0.197 False True IGHV4 IGLV1 Lambda None None None None None 6vpy H L 0 NA NA NA NA IMMUNE SYSTEM 02/04/20 I33M (I3.2 mutant from CH103 Lineage) HOMO SAPIENS homo sapiens homo sapiens Fera, D., Zhou, J. 2.36 X-RAY DIFFRACTION 0.223 0.185 False True IGHV4 IGLV3 Lambda None None None None None 7f9w B C 0 A protein NA interleukin-2 receptor subunit alpha ANTITUMOR PROTEIN 07/05/21 CD25 in complex with Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liu, C. 3.2 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV4 Kappa None None None None None 7ly9 H L 0 D protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 03/06/21 Cryo-EM structure of 2909 Fab in complex with 3BNC117 Fab and CAP256.wk34.c80 SOSIP.RnS2 N160K HIV-1 Env trimer HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.91 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 7we9 I K 0 F protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/23/21 SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv289 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Wang, L. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV1 Lambda None None None None None 7l7r D C 0 G protein NA glycoprotein c VIRAL PROTEIN 12/30/20 CCHFV Gc prefusion monomer bound to ADI-36121 and ADI-37801 Fabs HOMO SAPIENS; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS (STRAIN NIGERIA/IBAR10200/1970) homo sapiens homo sapiens crimean-congo hemorrhagic fever virus (strainnigeria/ibar10200/1970) Mishra, A.K., McLellan, J.S. 2.1 X-RAY DIFFRACTION 0.244 0.219 False True IGHV4 IGKV1 Kappa None None None None None 3ri5 G K 0 C protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/12/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.4 X-RAY DIFFRACTION 0.248 0.232 False True IGHV1 IGLV1 Lambda None None None None None 4xh2 E F 0 e peptide unknown CELL ADHESION 01/04/15 Crystal structure of human paxillin LD4 motif in complex with Fab fragment HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Nocula-Lugowska, M., Lugowski, M., Salgia, R., Kossiakoff, A.A. 2.0 X-RAY DIFFRACTION 0.258 0.224 False True IGHV3 IGKV1 Kappa 6.000000000000001e-09 -11.216608560689204 Unknown TBD 5w9l H I 0 G protein spike glycoprotein VIRAL PROTEIN 06/23/17 MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 MIDDLE EAST RESPIRATORY SYNDROME-RELATED CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus middle east respiratory syndrome-relatedcoronavirus Pallesen, J., Ward, A.B. 4.8 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6h0e A B 0 K peptide microtubule-associated protein tau IMMUNE SYSTEM 07/09/18 FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens mus musculus Juraszek, J., Steinbacher, S. 1.95 X-RAY DIFFRACTION 0.285 0.222 False True IGHV1 IGKV2 Kappa 2.4000000000000003e-07 -9.031007686639388 Unknown TBD 6pzy H K 0 E protein neuraminidase VIRAL PROTEIN/IMMUNE SYSTEM 08/01/19 CryoEM derived model of NA-73 Fab in complex with N9 Shanghai2 INFLUENZA A VIRUS (A/ENVIRONMENT/SHANGHAI/S1439/2013(H7N9)); HOMO SAPIENS homo sapiens homo sapiens influenza a virus(a/environment/shanghai/s1439/2013(h7n9)) Ward, A.B., Turner, H.L., Zhu, X. 3.17 ELECTRON MICROSCOPY False True IGHV4 IGLV1 Lambda None None None None None 3nn8 A B 0 IMMUNE SYSTEM 06/23/10 Crystal structure of engineered antibody fragment based on 3D5 MUS MUSCULUS mus musculus mus musculus Lieberman, R.L., Maynard, J.A., Drury, J.E., Pai, J., Culver, J.A. 3.1 X-RAY DIFFRACTION 0.238 0.183 True True IGHV1 IGKV1 Kappa None None None None None 5d70 H L 0 A protein granulocyte-macrophage colony-stimulating factor IMMUNE SYSTEM 08/13/15 Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF HOMO SAPIENS homo sapiens homo sapiens homo sapiens Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M. 2.06 X-RAY DIFFRACTION 0.222 0.190 False True IGHV3 IGLV3 Lambda 2e-09 -11.867518412372508 Unknown TBD 5vn3 K N 0 I protein envelope glycoprotein gp160 IMMUNE SYSTEM 04/28/17 Cryo-EM model of B41 SOSIP.664 in complex with soluble CD4 (D1-D2) and fragment antigen binding variable domain of 17b HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Pallesen, J., Ward, A.B. 3.7 ELECTRON MICROSCOPY / HOMOLOGY MODEL False True IGHV1 IGKV3 Kappa None None None None None 4f58 J N 0 IMMUNE SYSTEM 05/12/12 Fab structure of a neutralizing antibody L3 from an early subtype A HIV-1 infected patient HOMO SAPIENS homo sapiens homo sapiens Pan, R.M., Kong, X.P. 2.488 X-RAY DIFFRACTION 0.256 0.208 False False IGHV3 IGLV2 Lambda None None None None None 7elx h l 0 c protein NA unknown APOPTOSIS 04/12/21 The crystal structure of CTLA-4 and Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Yu, X.J., Wang, L., Yu, C.F. 2.14 X-RAY DIFFRACTION 0.217 0.177 False False IGHV3 IGKV3 Kappa None None None None None 6xzw H L 0 D protein NA lipoprot_c domain-containing protein IMMUNE SYSTEM 02/05/20 Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab. NEISSERIA MENINGITIDIS SEROGROUP B (STRAIN MC58); HOMO SAPIENS homo sapiens homo sapiens neisseria meningitidis serogroup b (strainmc58) Veggi, D., Cozzi, R. 2.4 X-RAY DIFFRACTION 0.250 0.200 False True IGHV3 IGKV3 Kappa None None None None None 7l79 H L 0 NA NA NA NA IMMUNE SYSTEM 12/27/20 Crystal structure of broadly HIV-1-neutralizing antibody VRC40.01 HOMO SAPIENS homo sapiens homo sapiens Zhou, T., Kwong, P.D. 2.826 X-RAY DIFFRACTION 0.280 0.220 False True unknown unknown unknown None None None None None 1uz8 H L 0 H carbohydrate MAG polysaccharide IMMUNE SYSTEM 03/05/04 anti-Lewis X Fab fragment in complex with Lewis X MUS MUSCULUS mus musculus mus musculus mus musculus Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P. 1.8 X-RAY DIFFRACTION 0.247 0.210 False False IGHV4 IGKV2 Kappa 1.1e-05 -6.764750720979343 Unknown TBD 6qkd NA T 0 IMMUNE SYSTEM 01/29/19 CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 LAMA GLAMA lama glama Kostareva, O.S., Kolyadenko, I.A., Ulitin, A.B., Ekimova, V.M., Evdokimov, S.R., Garber, M.B., Tishchenko, T.V., Gabdulkhakov, A.G. 1.9 X-RAY DIFFRACTION 0.228 0.169 False True IGKV3 Kappa None None None None None 5cp7 H A 0 IMMUNE SYSTEM 07/21/15 Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides MUS MUSCULUS mus musculus mus musculus Wang, Z., Shen, J., Li, C., Li, Y., Wen, K., Yu, X., Zhang, X. 3.01 X-RAY DIFFRACTION 0.302 0.260 False False IGHV3 IGKV1 Kappa None None None None None 3v6z A B 0 F protein e-antigen IMMUNE SYSTEM 12/20/11 Crystal Structure of Hepatitis B Virus e-antigen HEPATITIS B VIRUS; MUS MUSCULUS mus musculus mus musculus hepatitis b virus Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T. 3.34 X-RAY DIFFRACTION 0.233 0.234 False False IGHV5 IGKV8 Kappa 3.3e-09 -11.570817226937057 SPR TBD 4kdt B NA 0 C protein beta-2-microglobulin IMMUNE SYSTEM 04/25/13 Structure of an early native-like intermediate of beta2-microglobulin amyloidosis CAMELIDAE; HOMO SAPIENS camelidae homo sapiens Vanderhaegen, S., Fislage, M., Pardon, E., Versees, W., Steyaert, J. 2.6 X-RAY DIFFRACTION 0.274 0.226 False True IGHV1 None None None None None 4rgm C B 0 A protein enterotoxin type b TOXIN/IMMUNE SYSTEM 09/30/14 Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 20B1 STAPHYLOCOCCUS AUREUS; MUS MUSCULUS mus musculus mus musculus staphylococcus aureus Franklin, M.C., Dutta, K., Varshney, A.K., Goger, M.J., Fries, B.C. 2.689 X-RAY DIFFRACTION 0.277 0.225 False False IGHV9 IGKV9 Kappa 2.29e-08 -10.423049285339754 BLI TBD 5o4g B A 0 C protein receptor tyrosine-protein kinase erbb-2 ONCOPROTEIN 05/29/17 HER2 in complex with Fab MF3958 HOMO SAPIENS homo sapiens homo sapiens homo sapiens De Nardis, C., Gros, P. 3.0 X-RAY DIFFRACTION 0.271 0.229 False True IGHV1 IGKV1 Kappa None None None None None 7c80 H L 0 A | C | B protein | protein | protein NA | NA | NA vp1 | vp3 | vp2 VIRUS/IMMUNE SYSTEM 05/28/20 E30 F-particle in complex with 4B10 MUS MUSCULUS; ECHOVIRUS E30 mus musculus mus musculus echovirus e30 | echovirus e30 | echovirus e30 Wang, K., Zheng, B., Zhang, L., Cui, L., Su, X., Zhang, Q., Guo, Y., Zhu, L., Zhu, F., Rao, Z., Wang, X. 3.7 ELECTRON MICROSCOPY NA NA False False IGHV5 IGKV5 Kappa None None None None None 5thr M J 0 D protein bg505 sosip gp120 VIRAL PROTEIN 09/30/16 Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Wang, H., Bjorkman, P.J. 8.9, 8.9 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 6v4p C D 0 B | A protein | protein NA | NA integrin beta-3 | integrin alpha-iib Cell Adhesion/Immune System 11/28/19 Structure of the integrin AlphaIIbBeta3-Abciximab complex HOMO SAPIENS; UNIDENTIFIED unidentified unidentified homo sapiens | homo sapiens Nesic, D., Zhang, Y., Spasic, A., Li, J., Provasi, D., Filizola, M., Walz, T., Coller, B.S. 2.8 ELECTRON MICROSCOPY False True IGHV1 IGKV5 Kappa None None None None None 5hpm D C 0 IMMUNE SYSTEM 01/20/16 Cetuximab Fab in complex with cyclic linked meditope MUS MUSCULUS, HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens Bzymek, K.P., Williams, J.C. 2.67 X-RAY DIFFRACTION 0.232 0.187 False True IGHV2 IGKV5 Kappa 7.4e-08 -9.728108479311139 Unknown TBD 4h0i A a 0 a carbohydrate MMA O1-METHYL-MANNOSE IMMUNE SYSTEM 09/08/12 Crystal Structure of Scfv-2D10 in Complex with Methyl Alpha-D-Mannopyranoside MUS MUSCULUS mus musculus Tapryal, S., Gaur, V., Kaur, K.J., Salunke, D.M. 2.4 X-RAY DIFFRACTION 0.240 0.229 True True unknown unknown unknown None None None None None 7t6v E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/14/21 Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2 HOMO SAPIENS; RATTUS; BOS TAURUS; SYNTHETIC CONSTRUCT rattus homo sapiens | rattus Zhuang, Y.W. 3.1 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6gkd K NA 0 I protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 7d5z H G 0 E protein NA envelope glycoprotein h VIRAL PROTEIN 09/28/20 Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8 HUMAN GAMMAHERPESVIRUS 4; HOMO SAPIENS homo sapiens homo sapiens human gammaherpesvirus 4 Zhu, Q., Shan, S., Yu, J., Wang, X., Zhang, L., Zeng, M. 4.2 X-RAY DIFFRACTION 0.277 0.246 False True IGHV3 IGKV1 Kappa None None None None None 1qac NA B 0 IMMUNE SYSTEM 02/25/99 CHANGE IN DIMERIZATION MODE BY REMOVAL OF A SINGLE UNSATISFIED POLAR RESIDUE HOMO SAPIENS homo sapiens Pokkuluri, P.R., Cai, X., Johnson, G., Stevens, F.J., Schiffer, M. 1.8 X-RAY DIFFRACTION 0.226 0.193 False True IGKV4 Kappa None None None None None 4mhj T X 0 M protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 08/29/13 Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1) INFLUENZA A VIRUS; MUS MUSCULUS mus musculus mus musculus influenza a virus Zhu, X., Wilson, I.A. 6.98 X-RAY DIFFRACTION 0.387 0.377 False True IGHV1 IGKV3 Kappa 1e-09 -12.27819680469229 BLI TBD 6rlm G H 0 NA NA NA NA IMMUNE SYSTEM 05/02/19 Crystal structure of AT1412dm Fab fragment HOMO SAPIENS homo sapiens homo sapiens Neviani, V., Pearce, N.M., Pos, W., Schotte, R., Spits, H., Gros, P. 2.5 X-RAY DIFFRACTION 0.267 0.242 False True IGHV3 IGKV4 Kappa None None None None None 2kqm NA B 16 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 7tuy K NA 0 NA NA NA NA IMMUNE SYSTEM 02/03/22 Cryo-EM structure of GSK682753A-bound EBI2/GPR183 HOMO SAPIENS; SYNTHETIC CONSTRUCT; ESCHERICHIA COLI synthetic construct Chen, H., Huang, W., Li, X. 2.98 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 5mwn E NA 0 A protein type vi secretion protein TRANSPORT PROTEIN 01/18/17 Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 LAMA GLAMA; ESCHERICHIA COLI lama glama escherichia coli Cambillau, C., Nguyen, V.S., Spinelli, S., Legrand, P. 2.2 X-RAY DIFFRACTION 0.220 0.199 False True IGHV1 None None None None None 7lg6 P R 0 F protein NA envelope glycoprotein gp120 VIRAL PROTEIN/IMMUNE SYSTEM 01/19/21 BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; MACACA MULATTA homo sapiens homo sapiens human immunodeficiency virus 1 Cottrell, C.A., Torres, J.L., Wu, N.R., Ward, A.B. 3.28 ELECTRON MICROSCOPY NA NA False True unknown unknown unknown None None None None None 7nxb H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 03/17/21 Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhou, D., Ren, J., Stuart, D. 2.67 X-RAY DIFFRACTION 0.246 0.213 False True IGHV3 IGKV1 Kappa None None None None None 5ifj G H 0 I peptide peptide pro-leu-gln-pro-glu-gln-pro-phe-pro IMMUNE SYSTEM 02/26/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment in complex of peptide PLQPEQPFP HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens triticum aestivum Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 2.35 X-RAY DIFFRACTION 0.241 0.205 False True IGHV3 IGLV4 Lambda None None None None None 5mub C D 0 E peptide triple-helical peptide containing the citrullinated c1epitope of collagen type ii,collagen alpha-1(ii) chain,triple-helical peptide containing the citrullinated c1 epitope of collagen type ii IMMUNE SYSTEM 01/13/17 ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 3.1 X-RAY DIFFRACTION 0.264 0.231 False False IGHV6 IGKV3 Kappa None None None None None 1rfd H L 0 IMMUNE SYSTEM 11/07/03 ANTI-COCAINE ANTIBODY M82G2 MUS MUSCULUS mus musculus mus musculus Pozharski, E., Hewagama, A., Shanafelt, A.B., Petsko, G.A., Ringe, D. 2.09 X-RAY DIFFRACTION 0.226 0.183 False False IGHV6 IGKV2 Kappa None None None None None 7wf7 E e 0 B | C protein | protein NA | NA guanine nucleotide-binding protein g(i) subunit alpha-1 | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 12/26/21 Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to S1P HOMO SAPIENS homo sapiens homo sapiens | homo sapiens He, Y., Xu, Z. 3.4 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 7c2t V W 0 N protein NA envelope protein VIRUS 05/09/20 Helical reconstruction of Zika virus complexed with Fab C10 HOMO SAPIENS; ZIKA VIRUS homo sapiens homo sapiens zika virus Morrone, S., Chew, S.V., Lim, X.N., Ng, T.S., Kostyuchenko, V.A., Zhang, S., Lok, S.M. 9.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGLV2 Lambda None None None None None 1a14 H L 0 N protein neuraminidase COMPLEX (ANTIBODY/ANTIGEN) 12/21/97 COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE MUS MUSCULUS; INFLUENZA A VIRUS mus musculus mus musculus influenza a virus Malby, R.L., Mccoy, A.J., Kortt, A.A., Hudson, P.J., Colman, P.M. 2.5 X-RAY DIFFRACTION 0.270 0.200 False True IGHV1 IGKV10 Kappa None None None None None 6u6o H L 0 NA NA NA NA IMMUNE SYSTEM 08/30/19 Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846 MACACA MULATTA macaca mulatta macaca mulatta Chen, W.-H., Choe, M., Saunders, K.O., Joyce, M.G. 2.806 X-RAY DIFFRACTION 0.272 0.212 False True IGHV4 IGKV3 Kappa None None None None None 2qtj C N 8 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 4nwt H L 0 IMMUNE SYSTEM 12/06/13 Crystal structure of the anti-human NGF Fab APE1531 HOMO SAPIENS homo sapiens homo sapiens Verdino, P., Stanfield, R.L., Wilson, I.A. 1.75 X-RAY DIFFRACTION 0.181 0.150 False True IGHV1 IGKV4 Kappa None None None None None 5dsc C D 0 P peptide peptide IMMUNE SYSTEM 09/17/15 Context-independent anti-hypusine antibody FabHpu24.B in complex with hypusine ORYCTOLAGUS CUNICULUS; SYNTHETIC CONSTRUCT oryctolagus cuniculus oryctolagus cuniculus synthetic construct Zhai, Q., Carter, P.J. 2.4 X-RAY DIFFRACTION 0.248 0.207 False True IGHV1 IGKV1 Kappa None None None None None 6lgw A B 0 E protein glycoprotein,glycoprotein,glycoprotein VIRAL PROTEIN 12/06/19 Structure of Rabies virus glycoprotein in complex with neutralizing antibody 523-11 at acidic pH MUS MUSCULUS; RABIES LYSSAVIRUS mus musculus mus musculus rabies lyssavirus Yang, F.L., Lin, S., Ye, F., Yang, J., Qi, J.X., Chen, Z.J., Lin, X., Wang, J.C., Yue, D., Cheng, Y.W., Chen, Z.M., Chen, H., You, Y., Zhang, Z.L., Yang, Y., Yang, M., Sun, H.L., Li, Y.H., Cao, Y., Yang, S.Y., Wei, Y.Q., Gao, G.F., Lu, G.W. 2.9037 X-RAY DIFFRACTION 0.268 0.218 False True IGHV1 IGKV5 Kappa None None None None None 5m15 D NA 0 IMMUNE SYSTEM 10/07/16 Synthetic nanobody in complex with MBP ESCHERICHIA COLI K-12; SYNTHETIC CONSTRUCT synthetic construct Zimmermann, I., Egloff, P., Seeger, M.A. 1.9 X-RAY DIFFRACTION 0.257 0.209 False True IGHV1 None None None None None 7jti H L 0 A protein NA retinol-binding protein 3 TRANSPORT PROTEIN/IMMUNE SYSTEM 08/17/20 Interphotoreceptor retinoid-binding protein (IRBP) in complex with a monoclonal antibody (F3F5 mAb5) MUS MUSCULUS; BOS TAURUS mus musculus mus musculus bos taurus Sears, A.E., Albiez, S., Gulati, S., Wang, B., Kiser, P., Kovacik, L., Engel, A., Stahlberg, H., Palczewski, K. 7.4 ELECTRON MICROSCOPY NA NA False True IGHV2 IGLV1 Lambda None None None None None 1pew NA B 0 NA NA NA NA IMMUNE SYSTEM 05/22/03 High Resolution Crystal Structure of Jto2, a mutant of the non-amyloidogenic Lamba6 Light Chain, Jto HOMO SAPIENS homo sapiens Dealwis, C., Gupta, V., Wilkerson, M. 1.6 X-RAY DIFFRACTION 0.273 0.252 False True NA IGLV6 Lambda None None None None None 7e7e H L 0 A protein NA processed angiotensin-converting enzyme 2 ANTIVIRAL PROTEIN 02/26/21 The co-crystal structure of ACE2 with Fab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Xiao, J.Y., Zhang, Y. 3.8 X-RAY DIFFRACTION 0.327 0.276 False True IGHV3 IGKV1 Kappa None None None None None 6z3k O P 0 NA NA NA NA IMMUNE SYSTEM 05/20/20 Structure of protective antibody 38-1-10A Fab HOMO SAPIENS homo sapiens homo sapiens Zhou, D., Fry, E.E., Ren, J., Stuart, D.I. 2.7 X-RAY DIFFRACTION 0.234 0.188 False True IGHV4 IGKV1 Kappa None None None None None 6n2x H L 0 H carbohydrate NAG polysaccharide IMMUNE SYSTEM 11/14/18 Anti-HIV-1 Fab 2G12 + Man9 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 3.0 X-RAY DIFFRACTION 0.283 0.243 False True unknown IGKV1 Kappa None None None None None 5ywf B A 0 IMMUNE SYSTEM 11/29/17 Crystal structure of 2H4 Fab MUS MUSCULUS mus musculus mus musculus Qiu, X., Lei, Y., Yang, P., Gao, Q., Wang, N., Cao, L., Wang, X., Xu, Z.K., Rao, Z. 2.206 X-RAY DIFFRACTION 0.262 0.216 False False IGHV9 IGKV3 Kappa None None None None None 6ehx B b 0 IMMUNE SYSTEM 09/15/17 scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery HOMO SAPIENS homo sapiens Hargreaves, D. 2.2 X-RAY DIFFRACTION 0.241 0.207 True True unknown unknown unknown None None None None None 4kq4 H L 0 IMMUNE SYSTEM 05/14/13 Crystal structure of Anti-IL-17A antibody CNTO7357 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.45 X-RAY DIFFRACTION 0.279 0.210 False True IGHV1 IGKV6 Kappa None None None None None 3d69 B A 0 Immune System 05/19/08 Crystal Structure of the Fab Fragment of an Anti-Factor IX Antibody 10C12 HOMO SAPIENS mus musculus mus musculus Shi, X.L., Huang, M.D., Zeng, T. 3.77 X-RAY DIFFRACTION 0.342 0.249 False True IGHV3 IGLV1 Lambda None None None None None 6x9s H L 0 A | B protein | protein NA | NA hiv-1 envelope glycoprotein bg505 sosip.664 gp120 | hiv-1 envelope glycoprotein bg505 sosip.664 gp41 VIRAL PROTEIN/IMMUNE SYSTEM 06/03/20 HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in stable CHO cells in complex with RM20A3 Fab HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA macaca mulatta macaca mulatta human immunodeficiency virus 1 | human immunodeficiency virus 1 Berndsen, Z.T., Ward, A.B. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV2 Lambda None None None None None 1y0l B A 0 A Hapten HAN 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID immune system 11/15/04 Catalytic elimination antibody 34E4 in complex with hapten MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens mus musculus, homo sapiens Debler, E.W., Ito, S., Heine, A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.239 0.204 False True IGHV4 IGLV1 Lambda 1e-09 -12.27819680469229 Unknown TBD 5f8r D NA 0 B protein adhesin binding fucosylated histo-blood group antigen,adhesin,adhesin binding fucosylated histo-blood group antigen CELL ADHESION 12/09/15 Blood group antigen binding adhesin BabA of Helicobacter pylori strain S831 in complex with blood group H Lewis b hexasaccharide HELICOBACTER PYLORI; LAMA GLAMA lama glama helicobacter pylori Moonens, K., Gideonsson, P., Subedi, S., Romao, E., Oscarson, S., Muyldermans, S., Boren, T., Remaut, H. 2.44 X-RAY DIFFRACTION 0.219 0.189 False True IGHV1 None None None None None 3b2u W X 0 V protein epidermal growth factor receptor IMMUNE SYSTEM/TRANSFERASE 10/19/07 Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ferguson, K.M., Li, S., Kussie, P. 2.58 X-RAY DIFFRACTION 0.291 0.227 False True IGHV4 IGKV3 Kappa 1.00e-09 -12.27 SPR 25 18275813 2ih1 A B 0 C protein voltage-gated potassium channel MEMBRANE PROTEIN 09/25/06 Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation STREPTOMYCES LIVIDANS; MUS MUSCULUS mus musculus mus musculus streptomyces lividans Valiyaveetil, F.I., Leonetti, M., Muir, T.W., MacKinnon, R. 2.4 X-RAY DIFFRACTION 0.251 0.233 False False IGHV1 IGKV5 Kappa None None None None None 7r98 F NA 0 C protein NA nucleoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/28/21 Structure of the SARS-CoV-2 N protein RNA-binding domain bound to single-domain antibody B6 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Corbett, K.D., Ye, Q. 2.51 X-RAY DIFFRACTION 0.273 0.226 False True IGHV1 NA NA None None None None None 7faf d c 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 07/06/21 S protein of SARS-CoV-2 in complex bound with P36-5D2 (state1) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Zhang, L., Wang, X., Zhang, S., Shan, S. 3.69 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV1 Kappa None None None None None 7rd3 A B 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM 07/09/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.126 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 1.81 X-RAY DIFFRACTION 0.260 0.216 False True IGHV1 IGKV4 Kappa None None None None None 4gw5 D C 0 Immune system 08/31/12 cQYN meditope - Cetuximab Fab MURINAE,HOMO SAPIENS; SYNTHETIC CONSTRUCT murinae,homo sapiens murinae,homo sapiens Donaldson, J.M., Zer, C., Avery, K.N., Bzymek, K.P., Horne, D.A., Williams, J.C. 2.2 X-RAY DIFFRACTION 0.222 0.174 False True IGHV2 IGKV5 Kappa 3.5e-06 -7.443222922719666 Unknown TBD 3hb3 C D 0 B protein cytochrome c oxidase subunit 2 OXIDOREDUCTASE 05/04/09 High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase PARACOCCUS DENITRIFICANS; MUS MUSCULUS mus musculus mus musculus paracoccus denitrificans Koepke, J., Angerer, H., Peng, G. 2.25 X-RAY DIFFRACTION 0.280 0.218 False True IGHV5 IGKV12 Kappa None None None None None 7eh3 A NA 9 NA NA NA NA IMMUNE SYSTEM 03/28/21 Structure of Nanobody Nb23 in solution using NMR spectroscopy LAMA GLAMA lama glama Percipalle, M., Hunashal, Y., Esposito, G., Fogolari, F. NOT SOLUTION NMR NA NA False True IGHV1 NA NA None None None None None 6xw4 C NA 0 A protein capsid protein VIRAL PROTEIN 01/23/20 Crystal structure of murine norovirus P domain in complex with Nanobody NB-5867 MURINE NOROVIRUS 1; VICUGNA PACOS vicugna pacos murine norovirus 1 Kilic, T., Sabin, C., Hansman, G. 2.19 X-RAY DIFFRACTION 0.218 0.173 False True IGHV1 None None None None None 2kqn NA B 14 IMMUNE SYSTEM 11/11/09 Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 5yoy R O 0 J protein tumor necrosis factor IMMUNE SYSTEM 10/31/17 Crystal structure of the human tumor necrosis factor in complex with golimumab Fv HOMO SAPIENS homo sapiens homo sapiens homo sapiens Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N. 2.727 X-RAY DIFFRACTION 0.234 0.190 False True IGHV3 IGKV3 Kappa 1.8e-11 -14.658430977236662 Unknown TBD 4ngh H L 0 P peptide modified fragment of hiv glycoprotein (gp41) IMMUNE SYSTEM 11/01/13 Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41 and a tethered phosphate moiety. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens Irimia, A., Wilson, I.A. 2.68 X-RAY DIFFRACTION 0.223 0.169 False True IGHV1 IGKV3 Kappa None None None None None 5vf6 A a 0 IMMUNE SYSTEM 04/06/17 Crystal structure of single chain variable fragment (scFv45). GALLUS GALLUS gallus gallus Shrestha, O.K., Tocilj, A., Joshua-Tor, L., Tonks, N.K. 1.635 X-RAY DIFFRACTION 0.196 0.172 True True unknown unknown unknown None None None None None 5mv4 R S 0 T peptide synthetic peptide containing the citrullinated collagentype ii epitope cii616-639,collagen alpha-1(ii) chain,synthetic peptide containing the citrullinated collagen type ii epitope cii616- 639 IMMUNE SYSTEM 01/15/17 ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.9 X-RAY DIFFRACTION 0.247 0.232 False False IGHV6 IGKV3 Kappa None None None None None 4x7c D NA 0 B protein vp1 VIRAL PROTEIN 12/09/14 Crystal structure of Saga-2006 GII.4 P domain in complex with Nano-85 NOROVIRUS HU/GII-4/SAGA1/2006/JP; VICUGNA PACOS vicugna pacos norovirus hu/gii-4/saga1/2006/jp Koromyslova, A.D., Hansman, G.S. 2.0 X-RAY DIFFRACTION 0.218 0.166 False True IGHV1 None None None None None 5x0t C D 0 F protein basigin IMMUNE SYSTEM 01/23/17 Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8 MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Lin, P., Zhang, M.-Y., Ye, S., Chen, X., Yu, X.-L., Zhang, R.-G., Zhu, P., Chen, Z.-N. 2.5 X-RAY DIFFRACTION 0.300 0.246 False True IGHV6 IGKV6 Kappa None None None None None 6edu R S 0 D | A protein | protein NA | NA envelope glycoprotein gp160 | envelope glycoprotein gp160 IMMUNE SYSTEM 08/11/18 B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Barnes, C.O., Bjorkman, P.J. 4.06 ELECTRON MICROSCOPY False True unknown IGKV1 Kappa None None None None None 6mtr H L 0 IMMUNE SYSTEM 10/21/18 Crystal structure of VRC43.01 Fab HOMO SAPIENS homo sapiens homo sapiens Kwon, Y.D., Druz, A., Law, W.H., Peng, D., Zhang, B., Doria-Rose, N.A., Kwong, P.D. 1.798 X-RAY DIFFRACTION 0.243 0.209 False True IGHV4 IGLV7 Lambda None None None None None 7a6e C B 0 A protein NA multidrug resistance protein 1 TRANSPORT PROTEIN 08/25/20 Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nosol, K., Locher, K.P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV1 Kappa None None None None None 6mhg K V 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 1f3r b B 0 A peptide acetylcholine receptor alpha IMMUNE SYSTEM 06/06/00 COMPLEX BETWEEN FV ANTIBODY FRAGMENT AND AN ANALOGUE OF THE MAIN IMMUNOGENIC REGION OF THE ACETYLCHOLINE RECEPTOR RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT rattus norvegicus Kleinjung, J., Petit, M.-C., Orlewski, P., Mamalaki, A., Tzartos, S.-J., Tsikaris, V., Sakarellos-Daitsiotis, M., Sakarellos, C., Marraud, M., Cung, M.-T. NOT SOLUTION NMR / HOMOLOGY MODEL True True unknown unknown unknown None None None None None 4qex H L 0 A protein erythrocyte-binding antigen-175 IMMUNE SYSTEM 05/19/14 Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217 PLASMODIUM FALCIPARUM; MUS MUSCULUS mus musculus mus musculus plasmodium falciparum Chen, E., Paing, M.M., Salinas, N., Sim, B.K., Tolia, N.H. 4.5 X-RAY DIFFRACTION 0.285 0.232 False False IGHV1 IGKV3 Kappa None None None None None 7wcz a b 0 A protein NA heavy chain of s5d2 fab VIRAL PROTEIN 12/20/21 SARS-CoV-2 Beta spike in complex with one S5D2 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 3hr5 I P 0 T peptide m1prime-derived peptide IMMUNE SYSTEM 06/08/09 M1prime peptide from IgE bound by humanized antibody 47H4 Fab MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Eigenbrot, C.W., Ultsch, M.H. 2.4 X-RAY DIFFRACTION 0.253 0.213 False True IGHV3 IGKV1 Kappa None None None None None 2bx5 NA D 0 ANTIBODY 07/22/05 Is FR1 the antibody's Achillies heel ESCHERICHIA COLI James, L.C. 2.7 X-RAY DIFFRACTION 0.290 0.250 False True IGKV1 Kappa None None None None None 4r4b B A 0 NA NA NA NA IMMUNE SYSTEM 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Acharya, P., Huang, C.-C., Robinson, J., Kwong, P.D. 2.199 X-RAY DIFFRACTION 0.214 0.166 False True IGHV4 IGKV1 Kappa None None None None None 2qtj B M 8 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6ko5 H L 0 A protein NA chimera of soluble cytochrome b562 and growth hormonesecretagogue receptor type 1 MEMBRANE PROTEIN 08/08/19 Complex structure of Ghrelin receptor with Fab ESCHERICHIA COLI; HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus escherichia coli, homo sapiens Shiimura, Y., Horita, S., Asada, H., Hirata, K., Iwata, S., Kojima, M. 3.3 X-RAY DIFFRACTION 0.258 0.211 False False IGHV1 IGKV8 Kappa None None None None None 7bnw B NA 0 NA NA NA NA IMMUNE SYSTEM 01/22/21 Llama nanobody nb18 raised against GldL from Flavobacterium jonhsoniae LAMA GLAMA lama glama Trinh, N.T., Cambillau, C., Leone, P. 2.59 X-RAY DIFFRACTION 0.243 0.193 False True IGHV1 NA NA None None None None None 7l06 M K 0 A protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/11/20 Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Manne, K., Henderson, R., Acharya, P. 3.3 ELECTRON MICROSCOPY NA NA False True unknown IGKV1 Kappa None None None None None 5n7b H h 0 I peptide apd(cg6)rp(nh2) peptide IMMUNE SYSTEM 02/20/17 Understanding the singular conformational landscape of the Tn antigens: Sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus synthetic construct Companon, I., Martinez-Saez, N., Castro-Lopez, J., Jimenez-Barbero, J., Bernardes, G.J.L., Busto, J.H., Avenoza, A., Jimenez-Oses, G., Hurtado-Guerrero, R., Peregrina, J.M., Corzana, F. 1.7 X-RAY DIFFRACTION 0.211 0.176 True True unknown unknown unknown None None None None None 7zr9 H L 0 A protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/03/22 OMI-2 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE GLYCOPROTEIN SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3skj I M 0 F protein ephrin type-a receptor 2 IMMUNE SYSTEM 06/22/11 Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oganesyan, V.Y., Wu, H., Dall'Acqua, W.F. 2.5 X-RAY DIFFRACTION 0.271 0.216 False True IGHV3 IGKV1 Kappa 8.10e-10 -12.4 SPR 21867711 3qg6 H L 0 C peptide agr autoinducing peptide IMMUNE SYSTEM/INHIBITOR 01/24/11 Structural Basis for Ligand Recognition and Discrimination of a Quorum Quenching Antibody MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Kirchdoerfer, R.N., Janda, J.D., Kaufmann, G.F, Wilson, I.A 2.5 X-RAY DIFFRACTION 0.239 0.184 False True IGHV3 IGKV1 Kappa None None None None None 4lsq H L 0 G protein envelope glycoprotein gp120 with loop d and v5 from strain3415_v1_c1 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E gp120 93TH057 with LOOP D and Loop V5 from clade A strain 3415_v1_c1 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.25 X-RAY DIFFRACTION 0.229 0.192 False True unknown IGKV1 Kappa None None None None None 7a0v F NA 0 E protein NA synaptojanin-1 HYDROLASE 08/11/20 Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Paesmans, J., Galicia, C., Martin, E., Versees, W. 2.3 X-RAY DIFFRACTION 0.252 0.196 False True IGHV1 NA NA None None None None None 7wd9 I J 0 A protein NA spike glycoprotein VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with three S3H3 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.7 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV3 Kappa None None None None None 7mdw B NA 0 R protein NA spike protein s1 VIRAL PROTEIN/Immune System 04/06/21 CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb105 LAMA GLAMA; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 lama glama severe acute respiratory syndrome coronavirus2 Huang, W., Taylor, D.J. 3.58 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6xli H L 0 P peptide NA tau phosphopeptide (ac-sr(pt)pslp(pt)pptre-oh) IMMUNE SYSTEM 06/28/20 CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Malia, T.J., Teplyakov, A., Luo, J. 2.0 X-RAY DIFFRACTION 0.213 0.186 False True IGHV5 IGKV14 Kappa None None None None None 5dhz H L 0 M protein protein rev IMMUNE SYSTEM 08/31/15 HIV-1 Rev NTD dimers with variable crossing angles HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C. 4.3 X-RAY DIFFRACTION unknown unknown False True IGHV1 IGKV1 Kappa None None None None None 6rps H L 0 A protein carbonic anhydrase 12 LYASE 05/14/19 X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment HOMO SAPIENS homo sapiens homo sapiens homo sapiens Alterio, V., Esposito, D., De Simone, G. 2.79 X-RAY DIFFRACTION 0.231 0.203 False True IGHV2 IGKV5 Kappa None None None None None 6r7t A NA 0 B protein melanoma-associated antigen b1 IMMUNE SYSTEM 03/29/19 Crystal Structure of human Melanoma-associated antigen B1 (MAGEB1) in complex with nanobody LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ye, M., Newman, J., Pike, A.C.W., Burgess-Brown, N., Bountra, C., Arrowsmith, C., Edwards, A., Gileadi, O., von Delft, F. 2.682 X-RAY DIFFRACTION 0.288 0.258 False True IGHV3 None None None None None 1ymh B A 0 E protein protein l IMMUNE SYSTEM 01/21/05 anti-HCV Fab 19D9D6 complexed with protein L (PpL) mutant A66W FINEGOLDIA MAGNA; MUS MUSCULUS mus musculus mus musculus finegoldia magna Granata, V., Housden, N.G., Harrison, S., Jolivet-Reynaud, C., Gore, M.G., Stura, E.A. 2.6 X-RAY DIFFRACTION 0.302 0.224 False False IGHV9 IGKV8 Kappa None None None None None 2mmx NA A 8 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6xul H L 0 NA NA NA NA ANTITUMOR PROTEIN 01/20/20 Apo Ab 5b1 HOMO SAPIENS homo sapiens homo sapiens Diskin, R., Borenstein-Katz, A. 2.41 X-RAY DIFFRACTION 0.230 0.168 False True IGHV3 IGLV1 Lambda None None None None None 7rd4 H L 0 G peptide NA circumsporozoite protein IMMUNE SYSTEM 07/09/21 Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.149 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium falciparum Xu, K., Kwong, P.D. 1.75 X-RAY DIFFRACTION 0.233 0.194 False True IGHV1 IGKV4 Kappa None None None None None 1xf4 H L 0 IMMUNE SYSTEM 09/13/04 Structure of ligand-free Fab DNA-1 in space group P321 solved from crystals with perfect hemihedral twinning MUS MUSCULUS mus musculus mus musculus Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J. 2.5 X-RAY DIFFRACTION 0.224 0.183 False True IGHV1 IGKV12 Kappa None None None None None 4r4b H L 0 NA NA NA NA IMMUNE SYSTEM 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c HOMO SAPIENS homo sapiens homo sapiens McLellan, J.S., Acharya, P., Huang, C.-C., Robinson, J., Kwong, P.D. 2.199 X-RAY DIFFRACTION 0.214 0.166 False True IGHV4 IGKV1 Kappa None None None None None 1yec H L 0 H Hapten PNB 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE CATALYTIC ANTIBODY 04/15/97 STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.3) MUS MUSCULUS mus musculus mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 1.9 X-RAY DIFFRACTION 0.252 0.208 False False IGHV1 IGKV1 Kappa None None None None None 5grv L K 0 IMMUNE SYSTEM 08/12/16 Crystal structure of homo-specific diabody HOMO SAPIENS homo sapiens homo sapiens Kim, J.H., Song, D.H., Youn, S.J., Kim, J.W., Cho, G., Lee, H., Lee, J.O. 2.3 X-RAY DIFFRACTION 0.221 0.184 False True IGHV3 IGKV3 Kappa None None None None None 3whe 3 4 0 I protein hemagglutinin VIRAL PROTEIN/IMMUNE SYSTEM 08/25/13 A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus Fujii, Y., Sumida, T., Shirouzu, M., Yokoyama, S. 4.0 X-RAY DIFFRACTION 0.308 0.235 False True IGHV1 IGLV1 Lambda None None None None None 5m2i L NA 0 F protein tumor necrosis factor CYTOKINE 10/13/16 Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.15 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 5.400000000000001e-10 -12.643277036143104 SPR TBD 4tvs a NA 0 A protein vhh domain bs-1 MEMBRANE PROTEIN 06/27/14 LAP1(aa356-583), H.sapiens, bound to VHH-BS1 HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sosa, B.A., Schwartz, T.U. 1.6 X-RAY DIFFRACTION 0.229 0.181 False False IGHV1 None None None None None 6oyz G NA 0 C protein phospho-n-acetylmuramoyl-pentapeptide-transferase MEMBRANE PROTEIN/TRANSFERASE 05/15/19 Crystal structure of MraY bound to capuramycin LAMA GLAMA; AQUIFEX AEOLICUS (STRAIN VF5) lama glama aquifex aeolicus (strain vf5) Mashalidis, E.H., Lee, S.Y. 3.62 X-RAY DIFFRACTION 0.301 0.277 False True IGHV1 None None None None None 4xnm H L 0 C protein hemagglutinin Viral protein/Immune system 01/15/15 Antibody Influenza H5 Complex HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Winarski, K.L., Spiler, B.W. 2.51 X-RAY DIFFRACTION 0.241 0.214 False True IGHV4 IGLV3 Lambda 8e-09 -11.046161627732946 SPR TBD 5m2i I NA 0 C protein tumor necrosis factor CYTOKINE 10/13/16 Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Cambillau, C., Spinelli, S., Desmyter, A., de Haard, H. 2.15 X-RAY DIFFRACTION 0.238 0.207 False True IGHV1 5.400000000000001e-10 -12.643277036143104 SPR TBD 4pd4 J K 0 E protein cytochrome b-c1 complex subunit rieske, mitochondrial OXIDOREDUCTASE/INHIBITOR 04/17/14 Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action MUS MUSCULUS; SACCHAROMYCES CEREVISIAE mus musculus mus musculus saccharomyces cerevisiae Birth, D., Kao, W.-C., Hunte, C. 3.04 X-RAY DIFFRACTION 0.297 0.268 False True IGHV3 IGKV10 Kappa None None None None None 2ghw D d 0 C protein spike glycoprotein VIRUS/VIRAL PROTEIN/ANTIBIOTIC 03/27/06 Crystal structure of SARS spike protein receptor binding domain in complex with a neutralizing antibody, 80R SARS CORONAVIRUS; HOMO SAPIENS homo sapiens sars coronavirus Hwang, W.C., Lin, Y., Santelli, E., Sui, J., Jaroszewski, L., Stec, B., Farzan, M., Marasco, W.A., Liddington, R.C. 2.3 X-RAY DIFFRACTION 0.295 0.248 True True unknown unknown unknown None None None None None 6ur5 G H 0 D protein influenza hemagglutinin ha1 VIRAL PROTEIN/IMMUNE SYSTEM 06/10/20 Resurfaced influenza hemagglutinin in complex with a broadly neutralizing antibody HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Bajic, G., Schmidt, A.G. 4.0 X-RAY DIFFRACTION 0.322 0.300 False True IGHV1 IGLV2 Lambda None None None None None 4tuj C D 0 F peptide peptide1 IMMUNE SYSTEM 06/24/14 Crystal structure of monoclonal antibody against neuroblastoma associated antigen. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Grudnik, P., Golik, P., Horwacik, I., Zdzalik, M., Rokita, H., Dubin, G. 1.89 X-RAY DIFFRACTION 0.232 0.179 False True IGHV1 IGKV1 Kappa None None None None None 2mmx NA A 18 IMMUNE SYSTEM 03/20/14 NMR study of 6aJL2 HOMO SAPIENS homo sapiens Amero, C., Maya-Martinez, R.C., Gil-Rodriguez, P.C. NOT SOLUTION NMR False True IGLV6 Lambda None None None None None 6zhd F NA 0 B protein NA spike glycoprotein,fibritin ANTIVIRAL PROTEIN 06/22/20 H11-H4 bound to Spike SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Clare, D.K., Naismith, J.H., Weckener, M., Vogirala, V.K. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4web H L 0 E protein hepatitis c virus envelope glycoprotein 2 IMMUNE SYSTEM/VIRAL PROTEIN 09/09/14 Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 HEPATITIS C VIRUS SUBTYPE 2A; MUS MUSCULUS mus musculus mus musculus hepatitis c virus subtype 2a Khan, A.G., Whidby, J., Miller, M.T., Scarborough, H., Zatorski, A.V., Cygan, A., Price, A.A., Yost, S.A., Bohannon, C.D., Jacob, J., Grakoui, A., Marcotrigiano, J. 2.4 X-RAY DIFFRACTION 0.259 0.199 False True IGHV14 IGKV8 Kappa None None None None None 3csy A B 0 J | I protein | protein NA | NA envelope glycoprotein gp2 | envelope glycoprotein gp1 IMMUNE SYSTEM/VIRAL PROTEIN 04/10/08 Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor HOMO SAPIENS; ZAIRE EBOLA VIRUS homo sapiens homo sapiens zaire ebola virus | zaire ebola virus Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O. 3.4 X-RAY DIFFRACTION 0.302 0.261 False True IGHV3 IGKV4 Kappa None None None None None 5t6l H L 0 I protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 09/01/16 Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 2.1 X-RAY DIFFRACTION 0.218 0.178 False True IGHV3 IGLV3 Lambda 2.85e-11 -14.386165571647554 SPR TBD 7ntc H L 0 C protein NA spike glycoprotein VIRAL PROTEIN 03/09/21 Trimeric SARS-CoV-2 spike ectodomain bound to P008_056 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Rosa, A., Pye, V.E., Nans, A., Cherepanov, P. 3.6 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6o25 E F 0 H peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 3945 Fab in complex with circumsporozoite protein NANP3 and anti-Kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.9 X-RAY DIFFRACTION 0.268 0.215 False True IGHV3 IGKV3 Kappa None None None None None 6mu6 D E 0 B protein envelope glycoprotein gp160 IMMUNE SYSTEM/INHIBITOR 10/22/18 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-814508 in Complex with Human Antibodies 3H109L and 35O22 at 3.2 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.551 X-RAY DIFFRACTION 0.264 0.231 False True unknown unknown unknown None None None None None 6huk G NA 0 A | E protein | protein NA | NA gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 | gamma-aminobutyric acid receptor subunit beta-3 MEMBRANE PROTEIN 10/08/18 CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38. BOS TAURUS; HOMO SAPIENS; LAMA GLAMA lama glama bos taurus, homo sapiens | homo sapiens Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R. 3.69 ELECTRON MICROSCOPY False True unknown unknown unknown None None None None None 6nc2 Q V 0 K | E protein | protein NA | NA amc011 v4.2 sosip gp41 | amc011 v4.2 sosip gp120 IMMUNE SYSTEM 12/10/18 AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 | human immunodeficiency virus 1 Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B. 5.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 6vi1 F C 0 O peptide NA terminase, large subunit IMMUNE SYSTEM 01/11/20 Structure of Fab4 bound to P22 TerL(1-33) HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens salmonella phage p22 Cingolani, G., Lokareddy, R., Ko, Y. 2.4 X-RAY DIFFRACTION 0.239 0.189 False True IGHV3 IGKV1 Kappa None None None None None 1mce NA B 0 P peptide peptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-oh IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 7k75 M N 0 E peptide NA pfcsp n-terminal peptide p17 IMMUNE SYSTEM 09/22/20 Crystal structure of MAD2-6 IgA Fab in complex with PfCSP N-terminal peptide. HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.236 0.192 False True IGHV4 IGKV1 Kappa None None None None None 7k60 N n 0 G | F | H protein | protein | protein NA | NA | NA histone h2a type 1-b/e | histone h4 | histone h2b type 1-j NUCLEAR PROTEIN/DNA 09/17/20 Cryo-EM structure of a chromatosome containing human linker histone H1.10 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens | homo sapiens | homo sapiens Zhou, B.-R., Bai, Y. 3.12 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6mqm J K 0 L peptide hiv env fusion peptide residue 512-519 IMMUNE SYSTEM 10/10/18 Vaccine-elicited NHP FP-targeting neutralizing antibody DF1W-a.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 3.484 X-RAY DIFFRACTION 0.246 0.200 False True IGHV4 IGKV2 Kappa None None None None None 5t5n K J 0 B protein bestrophin-1 (best1) MEMBRANE PROTEIN 08/31/16 Calcium-activated chloride channel bestrophin-1 (BEST1), triple mutant: I76A, F80A, F84A; in complex with an Fab antibody fragment, chloride, and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Long, S.B., Vaisey, G. 3.1 X-RAY DIFFRACTION 0.243 0.218 False False IGHV1 IGKV12 Kappa None None None None None 7rdl B A 0 NA NA NA NA IMMUNE SYSTEM 07/09/21 Crystal structure of PCDN-22A, an anti-HIV antibody from the PCDN bnAb lineage HOMO SAPIENS homo sapiens homo sapiens Omorodion, O., Wilson, I.A. 2.71 X-RAY DIFFRACTION 0.258 0.230 False True IGHV4 IGKV3 Kappa None None None None None 5any L P 0 H | G protein | protein NA | NA e2 | e1 VIRUS 09/08/15 Electron cryo-microscopy of chikungunya virus in complex with neutralizing antibody Fab CHK265 CHIKUNGUNYA VIRUS; MUS MUSCULUS mus musculus mus musculus chikungunya virus | chikungunya virus Fox, J.M., Long, F., Edeling, M.A., Lin, H., Duijl-Richter, M., Fong, R.H., Kahle, K.M., Smit, J.M., Jin, J., Simmons, G., Doranz, B.J., Crowe, J.E., Fremont, D.H., Rossmann, M.G., Diamond, M.S. 16.9 ELECTRON MICROSCOPY NA NA False True IGHV9 IGLV1 Lambda None None None None None 6aj9 H L 0 C | B protein | protein NA | NA capsid protein vp3 | capsid protein vp2 VIRUS 08/27/18 The structure of Enterovirus D68 mature virion in complex with Fab 15C5 and 11G1 MUS MUSCULUS; ENTEROVIRUS D68 mus musculus mus musculus enterovirus d68 | enterovirus d68 Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV9 Kappa None None None None None 2qtj C O 6 IMMUNE SYSTEM 08/02/07 Solution structure of human dimeric immunoglobulin A HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Furtado, P.B., Almogren, A., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7s6k C D 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 09/14/21 J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 2) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Ozorowski, G., Torres, J.L., Ward, A.B. 3.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3j8w I M 0 B | A protein | protein NA | NA l1 | l1 VIRUS/IMMUNE SYSTEM 11/19/14 Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab MUS MUSCULUS; HUMAN PAPILLOMAVIRUS TYPE 16 mus musculus mus musculus human papillomavirus type 16 | human papillomavirus type 16 Guan, J., Hafenstein, S. 13 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV12 Kappa None None None None None 5hvh C NA 0 A protein carboxypeptidase b2 HYDROLASE/HYDROLASE INHIBITOR 01/28/16 Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 3.0 X-RAY DIFFRACTION 0.202 0.190 False True IGHV1 None None None None None 6avn H L 0 IMMUNE SYSTEM 09/03/17 Crystal structure of unbound anti-HIV antibody Fab PGV19 at 2.5 A HOMO SAPIENS homo sapiens homo sapiens Sarkar, A., Wilson, I.A. 2.5 X-RAY DIFFRACTION 0.250 0.199 False True unknown IGLV2 Lambda None None None None None 1mck NA B 0 P peptide peptide n-acetyl-d-glu-l-his-d-pro-nh2 IMMUNOGLOBULIN 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown unknown False True IGLV2 Lambda None None None None None 1ieh A NA 6 IMMUNE SYSTEM 04/09/01 SOLUTION STRUCTURE OF A SOLUBLE SINGLE-DOMAIN ANTIBODY WITH HYDROPHOBIC RESIDUES TYPICAL OF A VL/VH INTERFACE LAMA GLAMA lama glama Vranken, W., Tolkatchev, D., Xu, P., Tanha, J., Chen, Z., Narang, S., Ni, F. NOT SOLUTION NMR False True IGHV1 None None None None None 3chn C O 9 IMMUNE SYSTEM 03/10/08 Solution structure of human secretory IgA1 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING / HOMOLOGY MODEL False False IGHV1 IGKV1 Kappa None None None None None 3s88 H L 0 J | J | I carbohydrate | protein | protein NAG | NA | NA N-ACETYL-D-GLUCOSAMINE | envelope glycoprotein | envelope glycoprotein IMMUNE SYSTEM/VIRAL PROTEIN 05/27/11 Crystal structure of Sudan Ebolavirus Glycoprotein (strain Gulu) bound to 16F6 MUS MUSCULUS; SUDAN EBOLAVIRUS mus musculus mus musculus sudan ebolavirus | sudan ebolavirus | sudan ebolavirus Saphire, E.O., Dias, J.M., Bale, S. 3.351 X-RAY DIFFRACTION 0.278 0.222 False True IGHV5 IGKV6 Kappa None None None None None 3cm9 D O 7 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 7n5h E F 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/05/21 Cryo-EM structure of broadly neutralizing antibody 2-36 in complex with prefusion SARS-CoV-2 spike glycoprotein SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Casner, R.G., Cerutti, G., Shapiro, L. 3.24 ELECTRON MICROSCOPY NA NA False True IGHV4 IGKV3 Kappa None None None None None 4uok A L 0 IMMUNE SYSTEM 06/04/14 Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC-83 in complex with neutralizing antibody Fab 3B4C-4 HOMO SAPIENS homo sapiens homo sapiens Porta, J., Jose, J., Roehrig, J.T., Blair, C.D., Kuhn, R.J., G Rossmann, M. 18.0 ELECTRON MICROSCOPY False True IGHV1 IGKV3 Kappa None None None None None 4lsu H L 0 G protein hiv-1 clade a/e strain 93th057 gp120 viral protein/immune system 07/23/13 Crystal structure of broadly and potently neutralizing antibody VRC-PG20 in complex with HIV-1 clade A/E 93TH057 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Zhou, T., Moquin, S., Kwong, P.D. 2.3 X-RAY DIFFRACTION 0.234 0.179 False True IGHV1 IGLV2 Lambda None None None None None 6wzm A B 0 E protein NA interleukin-8 IMMUNE SYSTEM 05/14/20 LY3041658 Fab bound to CXCL8 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Durbin, J.D., Druzina, Z. 2.28 X-RAY DIFFRACTION 0.229 0.187 False True IGHV1 IGKV3 Kappa None None None None None 5m63 M N 0 N carbohydrate GAL polysaccharide IMMUNE SYSTEM 10/24/16 Crystal structure of group B Streptococcus type III DP2 oligosaccharide bound to Fab NVS-1-19-5 ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus oryctolagus cuniculus Carboni, F., Adamo, R., Veggi, D., Rappuoli, R., Malito, E., Margarit, I.R., Berti, F. 2.74 X-RAY DIFFRACTION 0.282 0.236 False True IGHV1 IGKV1 Kappa 1.0999999999999999e-07 -9.493238899799852 Unknown TBD 5c2b H L 0 IMMUNE SYSTEM 06/15/15 anti-CXCL13 parental scFv - 3B4 HOMO SAPIENS homo sapiens homo sapiens Tu, C., Bard, J., Mosyak, L. 1.4049 X-RAY DIFFRACTION 0.194 0.179 True True IGHV1 IGLV2 Lambda None None None None None 6ofi H L 0 G protein NA clade a/e 93th057 hiv-1 gp120 core IMMUNE SYSTEM 03/29/19 CRYSTAL STRUCTURE OF the RV144 C1-C2 SPECIFIC ANTIBODY CH55 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Tolbert, W.D., Yan, F., Van, V., Pazgier, M. 3.85 X-RAY DIFFRACTION 0.326 0.271 False True IGHV1 IGKV3 Kappa None None None None None 5bk3 E F 0 F carbohydrate NAG polysaccharide IMMUNE SYSTEM 09/12/17 Crystal structure of the neutralizing anti-circumsporozoite protein 580 antibody HOMO SAPIENS homo sapiens homo sapiens homo sapiens Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 2.8 X-RAY DIFFRACTION 0.231 0.190 False True IGHV3 IGKV4 Kappa None None None None None 4yk4 Z Y 0 E protein hemagglutinin Viral protein/Immune system 03/03/15 Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Schmidt, A.G., Harrison, S.C. 2.8 X-RAY DIFFRACTION 0.260 0.220 False True IGHV4 IGKV1 Kappa 3.64e-07 -8.78422937966864 BLI TBD 6h6y G NA 0 C protein capsid protein vp1 VIRAL PROTEIN 12/19/18 GI.1 human norovirus protruding domain in complex with Nano-7 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Ruoff, K., Hansman, G.S. 1.58 X-RAY DIFFRACTION 0.175 0.155 False True IGHV1 None None None None None 5iie A B 0 IMMUNE SYSTEM 03/01/16 STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 HOMO SAPIENS homo sapiens homo sapiens Nicely, N.I., Haynes, B.F. 2.8 X-RAY DIFFRACTION 0.273 0.206 False True IGHV2 IGLV1 Lambda None None None None None 1r24 D C 0 IMMUNE SYSTEM 11/05/98 FAB FROM MURINE IGG3 KAPPA MUS MUSCULUS mus musculus mus musculus Evans, S.V. 3.1 X-RAY DIFFRACTION unknown 0.245 False False IGHV5 IGKV10 Kappa None None None None None 7vyt H L 0 T protein NA t-cell immunoreceptor with ig and itim domains IMMUNE SYSTEM 11/15/21 Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Jeong, B.-S., Nam, H., Kim, M., Oh, B.-H. 1.53 X-RAY DIFFRACTION 0.219 0.201 False True IGHV1 IGKV3 Kappa None None None None None 2ajz B A 0 A Hapten ECG 3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER IMMUNE SYSTEM 08/02/05 Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, X., Wilson, I.A. 2.3 X-RAY DIFFRACTION 0.285 0.238 False False IGHV3 IGKV2 Kappa None None None None None 3o11 B A 0 IMMUNE SYSTEM 07/20/10 Anti-beta-amyloid antibody c706 fab in space group c2 MUS MUSCULUS, HOMO SAPIENS mus musculus, homo sapiens mus musculus, homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.8 X-RAY DIFFRACTION 0.304 0.220 False True IGHV1 IGKV4 Kappa None None None None None 1yed B A 0 A Hapten PNB 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE CATALYTIC ANTIBODY 04/15/97 STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4) MUS MUSCULUS mus musculus mus musculus mus musculus Golinelli-Pimpaneau, B., Knossow, M. 3.1 X-RAY DIFFRACTION 0.260 0.215 False False IGHV1 IGKV1 Kappa None None None None None 5d96 C B 0 A protein sulfhydryl oxidase 1 IMMUNE SYSTEM 08/18/15 Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from an Antibody Targeting Mouse and Human QSOX1 OTHER SEQUENCES; MUS MUSCULUS other sequences other sequences mus musculus Fass, D., Grossman, I. 2.3 X-RAY DIFFRACTION 0.228 0.167 False True IGHV2 IGKV6 Kappa None None None None None 5aam A a 0 C protein envelope protein 07/27/15 Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency MUS MUSCULUS; DENGUE VIRUS mus musculus dengue virus Wong, Y.H., Robinson, L.N., Lescar, J., Sasisekharan, R. 2.49 X-RAY DIFFRACTION 0.2698 0.2196 True True unknown unknown unknown 3.8e-09 -11.487230459870787 SPR TBD 7rm3 A B 0 Q peptide NA peptide from circumsporozoite protein variant vk247 ANTIMICROBIAL PROTEIN 07/26/21 Antibody 2E10.E9 in complex with P. vivax CSP peptide ANGAGNQPGANGAGNQPGANGAGGQAA MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus plasmodium vivax Kucharska, I., Ivanochko, D., Julien, J.P. 2.68 X-RAY DIFFRACTION 0.239 0.207 False True IGHV9 IGKV8 Kappa None None None None None 5jxa H L 0 IMMUNE SYSTEM 05/12/16 Crystal structure of ligand-free VRC03 antigen-binding fragment. HOMO SAPIENS homo sapiens homo sapiens Zhou, T., Moquin, S., Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.6 X-RAY DIFFRACTION 0.180 0.160 False True unknown IGKV3 Kappa None None None None None 5vxj B NA 0 A protein NA invasin ipad IMMUNE SYSTEM 05/23/17 2.50 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-E3 SHIGELLA FLEXNERI; VICUGNA PACOS vicugna pacos shigella flexneri Barta, M.L., Lovell, S., Battaile, K.P., Picking, W.D., Picking, W.L. 2.5 X-RAY DIFFRACTION 0.259 0.196 False True IGHV1 NA NA None None None None None 6k2i A NA 16 AFB1-BINDING PROTEIN 05/14/19 Solution structure of camelid nanobody Nb11 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., Li, S.L., He, T., Zhu, J., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 7c95 B A 0 NA NA NA NA IMMUNE SYSTEM 06/04/20 Crystal structure of the anti-human podoplanin antibody Fab fragment MUS MUSCULUS mus musculus mus musculus Nakamura, S., Suzuki, K., Ogasawara, S., Naruchi, K., Shimabukuro, J., Tukahara, N., Kaneko, M.K., Kato, Y., Murata, T. 2.13 X-RAY DIFFRACTION 0.237 0.204 False False IGHV5 IGKV8 Kappa None None None None None 5ihu H L 0 IMMUNE SYSTEM 02/29/16 Crystal structure of bovine Fab B11 BOS TAURUS bos taurus bos taurus Stanfield, R., Wilson, I. 2.06 X-RAY DIFFRACTION 0.235 0.194 False True IGHV1 IGLV1 Lambda None None None None None 4xvs H L 0 G protein donor 45 01dg5 coree gp120 Viral protein/Immune system 01/27/15 Crystal structure of HIV-1 donor 45 d45-01dG5 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Joyce, M.G., Mascola, J.R., Kwong, P.D. 1.9 X-RAY DIFFRACTION 0.214 0.194 False True unknown IGKV3 Kappa None None None None None 1f11 B A 0 IMMUNE SYSTEM 05/18/00 F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY MUS MUSCULUS mus musculus mus musculus Saul, F.A., Vulliez-Le Normand, B., Passafiume, M., Riottot, M.M., Bentley, G.A. 3.0 X-RAY DIFFRACTION 0.271 0.184 False False IGHV1 IGKV3 Kappa None None None None None 6wfz A B 0 C peptide NA npna3 peptide IMMUNE SYSTEM 04/04/20 Crystal structure of Fab399 in complex with NPNA3 peptide from circumsporozoite protein HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Pholcharee, T., Oyen, D., Wilson, I.A. 1.84 X-RAY DIFFRACTION 0.225 0.186 False True IGHV3 IGKV2 Kappa None None None None None 7n62 H L 0 A protein NA spike glycoprotein VIRAL PROTEIN/Immune System 06/07/21 SARS-CoV-2 Spike (2P) in complex with C12C9 Fab (NTD local reconstruction) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Windsor, I.W., Jenni, S., Bajic, G., Tong, P., Gautam, A.K., Wesemann, D.R., Harrison, S.C. 4 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV3 Kappa None None None None None 4dk6 A NA 0 D protein rna-editing complex protein mp81 RNA BINDING PROTEIN/IMMUNE SYSTEM 02/03/12 Structure of Editosome protein LAMA GLAMA; TRYPANOSOMA BRUCEI lama trypanosoma brucei Park, Y.-J., Hol, W. 2.65 X-RAY DIFFRACTION 0.264 0.224 False True IGHV1 None None None None None 6mek H L 0 C protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HEPACIVIRUS C; HOMO SAPIENS homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 3.1 X-RAY DIFFRACTION 0.290 0.223 False True IGHV1 IGKV1 Kappa None None None None None 7bz2 N NA 0 B | A protein | protein NA | NA guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 | guanine nucleotide-binding protein g(s) subunit alphaisoforms short SIGNALING PROTEIN 04/26/20 Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. HOMO SAPIENS; BOS TAURUS; LAMA GLAMA lama glama bos taurus | homo sapiens Zhang, Y.N., Yang, F., Ling, S.L., Lv, P., Zhou, Y.X., Fang, W., Sun, W., Shi, P., Tian, C.L. 3.82 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7cyp G F 0 B protein NA sars-cov-2 spike glycoprotein VIRAL PROTEIN 09/04/20 Complex of SARS-CoV-2 spike trimer with its neutralizing antibody HB27 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Wang, X., Zhu, L. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV5 IGKV3 Kappa None None None None None 5ihz A B 0 IMMUNE SYSTEM 03/01/16 Crystal structure of anti-gliadin 1002-1E01 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M. 1.64 X-RAY DIFFRACTION 0.229 0.200 False True IGHV3 IGLV4 Lambda None None None None None 1eo8 H L 0 A protein hemagglutinin (ha1 chain) Viral protein/Immune system 03/22/00 INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY INFLUENZA A VIRUS (A/X-31(H3N2)); MUS MUSCULUS mus musculus mus musculus influenza a virus (a/x-31(h3n2)) Fleury, D., Gigant, B., Daniels, R.S., Skehel, J.J., Knossow, M., Bizebard, T. 2.8 X-RAY DIFFRACTION 0.298 0.196 False False IGHV1 IGKV4 Kappa 8.90e-09 -10.87 SPR 22 10899782 6u59 F E 0 C protein sosip.664 gp120,sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 08/27/19 HIV-1 B41 SOSIP.664 in complex with rabbit antibody 13B HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus human immunodeficiency virus 1 Yang, Y.R., Ward, A.B. 3.86 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 4k3j H L 0 B protein hepatocyte growth factor beta chain Transferase/Immune System/Growth Factor 04/10/13 Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta HOMO SAPIENS; SYNTHETIC CONSTRUCT synthetic construct synthetic construct homo sapiens Ma, X., Starovasnik, M.A. 2.8 X-RAY DIFFRACTION 0.253 0.211 False True IGHV3 IGKV1 Kappa 1.2e-09 -12.170174257779676 SPR TBD 3mj9 H L 0 A protein junctional adhesion molecule-like IMMUNE SYSTEM 04/12/10 Crystal structure of JAML in complex with the stimulatory antibody HL4E10 MUS MUSCULUS; CRICETULUS MIGRATORIUS cricetulus migratorius cricetulus migratorius mus musculus Verdino, P., Wilson, I.A. 2.95 X-RAY DIFFRACTION 0.287 0.222 False False IGHV2 IGLV3 Lambda 7.69e-09 -11.06 SPR 25 21220118 1uz8 B A 0 H carbohydrate MAG polysaccharide IMMUNE SYSTEM 03/05/04 anti-Lewis X Fab fragment in complex with Lewis X MUS MUSCULUS mus musculus mus musculus mus musculus Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P. 1.8 X-RAY DIFFRACTION 0.247 0.210 False False IGHV4 IGKV2 Kappa 1.1e-05 -6.764750720979343 Unknown TBD 7w55 E e 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(q) subunit alpha | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/29/21 Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex HOMO SAPIENS homo sapiens homo sapiens | homo sapiens You, C., Xu, H.E., Jiang, Y. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 6x04 D NA 0 C protein NA nucleoporin nup133 STRUCTURAL PROTEIN 05/15/20 Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN5 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); VICUGNA PACOS vicugna pacos saccharomyces cerevisiae (strain atcc 204508 /s288c) Nordeen, S.A., Schwartz, T.U. 2.68 X-RAY DIFFRACTION 0.261 0.244 False True IGHV1 NA NA None None None None None 4krm H NA 0 G protein epidermal growth factor receptor TRANSFERASE/IMMUNE SYSTEM 05/16/13 Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens Ferguson, K.M., Schmitz, K.R. 2.655 X-RAY DIFFRACTION 0.244 0.208 False True IGHV1 None None None None None 6ell A B 0 IMMUNE SYSTEM 09/29/17 FAB Fragment. AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery HOMO SAPIENS homo sapiens homo sapiens Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G. 1.9 X-RAY DIFFRACTION 0.245 0.203 False True IGHV4 IGKV1 Kappa None None None None None 2igf H L 0 P peptide peptide (residues 69-87 of myohemerythrin) IMMUNOGLOBULIN 03/21/91 CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS MUS MUSCULUS mus musculus mus musculus Stanfield, R.L., Wilson, I.A. 2.8 X-RAY DIFFRACTION unknown 0.220 False True IGHV5 IGKV1 Kappa None None None None None 3pnw T S 0 U protein tudor domain-containing protein 3 PROTEIN BINDING/IMMUNE SYSTEM 11/19/10 Crystal Structure of the tudor domain of human TDRD3 in complex with an anti-TDRD3 FAB HOMO SAPIENS, SYNTHETIC CONSTRUCT; HOMO SAPIENS synthetic synthetic homo sapiens Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC) 2.05 X-RAY DIFFRACTION 0.264 0.223 False True IGHV3 IGKV1 Kappa None None None None None 1jnh D C 0 H Hapten ECO ESTRADIOL-6 CARBOXYL-METHYL-OXIME IMMUNE SYSTEM 07/24/01 Crystal Structure of Fab-Estradiol Complexes MUS MUSCULUS mus musculus mus musculus mus musculus Monnet, C., Bettsworth, F., Stura, E.A., Le Du, M.-H., Menez, R., Derrien, L., Zinn-Justin, S., Gilquin, B., Sibai, G., Battail-Poirot, N., Jolivet, M., Menez, A., Arnaud, M., Ducancel, F., Charbonnier, J.B. 2.85 X-RAY DIFFRACTION 0.253 0.198 False False IGHV1 IGLV1 Lambda None None None None None 6mwx C D 0 B protein NA e2 VIRUS/IMMUNE SYSTEM 10/30/18 CryoEM structure of Chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-69 Antibody EASTERN EQUINE ENCEPHALITIS VIRUS; MUS MUSCULUS mus musculus mus musculus eastern equine encephalitis virus Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G. 8.2 ELECTRON MICROSCOPY NA NA False False IGHV9 IGLV1 Lambda None None None None None 4fhb D NA 0 A protein dihydrofolate reductase Oxidoreductase/protein binding 06/06/12 Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179) ESCHERICHIA COLI; LAMA GLAMA lama glama escherichia coli Oyen, D. 2.8 X-RAY DIFFRACTION 0.296 0.217 False True IGHV1 None None None None None 4ldl B NA 0 A protein lysozyme, beta-2 adrenergic receptor MEMBRANE PROTEIN/HYDROLASE 06/24/13 Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody LAMA GLAMA; ENTEROBACTERIA PHAGE T4, HOMO SAPIENS lama glama enterobacteria phage t4, homo sapiens Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K. 3.1 X-RAY DIFFRACTION 0.254 0.229 False True IGHV1 None None None None None 4uin H L 0 H Hapten QI9 Quinine 03/30/15 crystal structure of quinine-dependent Fab 314.3 with quinine MUS MUSCULUS mus musculus mus musculus mus musculus Zhu, J., Zhu, J., Bougie, D.W., Aster, R.H., Springer, T.A. 2.5 X-RAY DIFFRACTION 0.2544 0.2030 False False IGHV1 IGKV10 Kappa 2.4000000000000003e-08 -10.395251776049642 Unknown TBD 3hc0 A B 0 IMMUNE SYSTEM 05/05/09 BHA10 IgG1 wild-type Fab - antibody directed at human LTBR HOMO SAPIENS homo sapiens homo sapiens Arndt, J.W., Jordan, J.L., Lugovskoy, A., Wang, D. 1.9 X-RAY DIFFRACTION 0.206 0.180 False True IGHV1 IGKV1 Kappa None None None None None 6uun N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 10/30/19 CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama homo sapiens | homo sapiens Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R. 3 ELECTRON MICROSCOPY False True IGHV3 None None None None None 6i6j C NA 0 A protein er lumen protein-retaining receptor 2 MEMBRANE PROTEIN 11/15/18 Crystal structure of the KDEL receptor bound to synthetic nanobody. GALLUS GALLUS; UNIDENTIFIED unidentified gallus gallus Braeuer, P., Newstead, S. 2.23 X-RAY DIFFRACTION 0.247 0.211 False True IGHV1 None None None None None 7dhi N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 11/15/20 Cryo-EM structure of the partial agonist salbutamol-bound beta2 adrenergic receptor-Gs protein complex. HOMO SAPIENS; BOS TAURUS; LAMA GLAMA lama glama homo sapiens | bos taurus Yang, F., Ling, S.L., Zhou, Y.X., Zhang, Y.N., Lv, P., Liu, S.L., Fang, W., Sun, W.J., Hu, L.Y.A. 3.26 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6iyn A NA 13 AFLATOXIN B1-BINDING PROTEIN 12/17/18 Solution structure of camelid nanobody Nb26 against aflatoxin B1 VICUGNA PACOS vicugna pacos Nie, Y., He, T., Zhu, J., Li, S.L., Hu, R., Yang, Y.H. NOT SOLUTION NMR False True IGHV1 None None None None None 3bgf B C 0 A protein spike protein s1 Viral Protein/Immune System 11/26/07 X-ray crystal structure of the SARS coronavirus spike receptor binding domain in complex with F26G19 Fab SARS CORONAVIRUS; MUS MUSCULUS mus musculus mus musculus sars coronavirus Pak, J.E., Rini, J.M. 3.0 X-RAY DIFFRACTION 0.286 0.234 False False IGHV1 IGKV9 Kappa 2.60e-08 -10.34 SPR 25 19324051 6itc V NA 0 Y | E protein | protein NA | NA protein translocase subunit secy | protein translocase subunit sece PROTEIN TRANSPORT 11/21/18 Structure of a substrate engaged SecA-SecY protein translocation machine BACILLUS SUBTILIS (STRAIN 168); GEOBACILLUS THERMODENITRIFICANS (STRAIN NG80-2); LAMA GLAMA; ESCHERICHIA COLI; AEQUOREA VICTORIA lama glama geobacillus thermodenitrificans (strain ng80-2) | geobacillus thermodenitrificans (strain ng80-2) Ma, C.Y., Wu, X.F., Sun, D.J., Park, E.Y., Rapoport, T.A., Gao, N., Long, L. 3.45 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 6q23 G I 0 D protein neuraminidase VIRAL PROTEIN,HYDROLASE/IMMUNE SYSTEM 08/06/19 Crystal structure of human 1G01 Fab in complex with influenza virus neuraminidase from A/California/04/2009 (H1N1) INFLUENZA A VIRUS (A/CALIFORNIA/04/2009 (H1N1); HOMO SAPIENS homo sapiens homo sapiens influenza a virus (a/california/04/2009 (h1n1) Zhu, X., Wilson, I.A. 3.27 X-RAY DIFFRACTION 0.241 0.196 False True IGHV3 IGKV1 Kappa None None None None None 5cma B A 0 IMMUNE SYSTEM 07/16/15 Anti-B7-H3 monoclonal antibody ch8H9 Fab fragment MUS MUSCULUS mus musculus mus musculus Ahmed, M., Goldgur, Y., Cheng, M., Cheung, N.K. 2.5 X-RAY DIFFRACTION 0.261 0.208 False True IGHV1 IGKV5 Kappa None None None None None 2mcp H L 0 H Hapten PC PHOSPHOCHOLINE IMMUNOGLOBULIN 10/15/84 REFINED CRYSTAL STRUCTURE OF THE MC/PC603 FAB-PHOSPHOCHOLINE COMPLEX AT 3.1 ANGSTROMS RESOLUTION MUS MUSCULUS mus musculus mus musculus mus musculus Padlan, E.A., Cohen, G.H., Davies, D.R. 3.1 X-RAY DIFFRACTION unknown 0.185 False True IGHV7 IGKV8 Kappa None None None None None 7mw3 F G 0 B protein NA spike glycoprotein VIRAL PROTEIN/Immune System 05/15/21 Structure of the SARS-CoV-2 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Hu, Y., Xiong, Y. 3.15 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 1yek H L 0 H Hapten NPO P-NITROPHENOL IMMUNE SYSTEM 08/13/98 CATALYTIC ANTIBODY D2.3 COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Knossow, M. 2.1 X-RAY DIFFRACTION 0.237 0.200 False False IGHV1 IGKV1 Kappa None None None None None 6nbi N NA 0 A | B protein | protein NA | NA gs protein alpha subunit | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SIGNALING PROTEIN 12/07/18 Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT synthetic construct bos taurus | rattus norvegicus Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y. 4.0 ELECTRON MICROSCOPY False True IGHV3 None None None None None 3dgg B A 0 IMMUNE SYSTEM 06/13/08 Crystal structure of FabOX108 HOMO SAPIENS homo sapiens homo sapiens Ren, J., Nettleship, J.E., Owens, R.J., Oxford Protein Production Facility (OPPF) 2.3 X-RAY DIFFRACTION 0.246 0.187 False True IGHV1 IGKV4 Kappa None None None None None 6bzy H L 0 B peptide e2 as412 peptide IMMUNE SYSTEM 12/26/17 Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the 22D11 broadly neutralizing antibody MUS MUSCULUS; HEPACIVIRUS C mus musculus mus musculus hepacivirus c Tzarum, N., Alemn, F., Wilson, I.A., Law, M. 1.6 X-RAY DIFFRACTION 0.218 0.188 False True IGHV2 IGKV3 Kappa None None None None None 5f3h C D 0 I protein growth/differentiation factor 8 Signaling Protein/Immune System 12/02/15 Structure of myostatin in complex with humanized RK35 antibody MUS MUSCULUS; HOMO SAPIENS mus musculus mus musculus homo sapiens Parris, K.D., Mosyak, L. 2.7 X-RAY DIFFRACTION 0.270 0.218 False True IGHV3 IGKV1 Kappa None None None None None 3rif J M 0 E protein avermectin-sensitive glutamate-gated chloride channel gluclalpha transport protein/immune system 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.345 X-RAY DIFFRACTION 0.271 0.248 False True IGHV1 IGLV1 Lambda None None None None None 4tyu A NA 0 IMMUNE SYSTEM 07/09/14 Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) LAMA GLAMA lama glama Legler, P.M. 2.13 X-RAY DIFFRACTION 0.263 0.239 False True IGHV1 None None None None None 5x8l J O 0 E protein programmed cell death 1 ligand 1 IMMUNE SYSTEM 03/03/17 PD-L1 in complex with atezolizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Heo, Y.S., Lee, H.T. 3.1 X-RAY DIFFRACTION 0.256 0.208 False True IGHV3 IGKV1 Kappa None None None None None 2zuq C B 0 A protein disulfide bond formation protein b Oxidoreductase/IMMUNE SYSTEM 10/28/08 Crystal structure of DsbB-Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Inaba, K., Suzuki, M., Murakami, S. 3.3 X-RAY DIFFRACTION 0.351 0.275 False False IGHV5 IGKV8 Kappa None None None None None 6vmk H G 0 I protein NA fab y49r heavy chain HYDROLASE/IMMUNE SYSTEM 01/28/20 Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Wu, P., Harris, S.F., Eigenbrot, C. 3.01 X-RAY DIFFRACTION 0.215 0.174 False True IGHV1 IGKV1 Kappa None None None None None 4zg1 F NA 0 PROTEIN BINDING 04/22/15 Crystal structure of a nanobody raised against KDM5b LAMA GLAMA lama glama Wiuf, A., Kristensen, O., Gajhede, M. 1.85 X-RAY DIFFRACTION 0.235 0.186 False True IGHV1 None None None None None 6ejm I i 0 A protein cd81 antigen CELL ADHESION 09/22/17 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 5 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Kuglstatter, A., Harris, S.F., Villasenor, A. 2.15 X-RAY DIFFRACTION 0.278 0.215 True True unknown unknown unknown 8.6e-10 -12.367556905430469 SPR TBD 6n16 H L 0 F peptide hiv fusion peptide (512-519) IMMUNE SYSTEM 11/08/18 Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-b.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.302 X-RAY DIFFRACTION 0.274 0.222 False True IGHV4 IGKV2 Kappa None None None None None 7l7d H L 0 E protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 12/28/20 Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibody AZD8895 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Dong, J., Crowe, J.E. 2.5 X-RAY DIFFRACTION 0.231 0.185 False True IGHV1 IGKV3 Kappa None None None None None 7c2e N NA 0 A | B protein | protein NA | NA guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 05/07/20 GLP-1R-Gs complex structure with a small molecule full agonist HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens | homo sapiens Ma, H., Yuan, D.P., Huang, W., Wenge, Z., Xu, E. 4.2 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 6wm9 E F 0 D protein NA reticulocyte binding protein 2b CELL INVASION 04/20/20 Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 237235 PLASMODIUM VIVAX (STRAIN SALVADOR I); HOMO SAPIENS homo sapiens homo sapiens plasmodium vivax (strain salvador i) Chan, L.J., Dietrich, M.H., Tham, W.H. 2.45 X-RAY DIFFRACTION 0.279 0.223 False True IGHV3 IGLV2 Lambda None None None None None 4r4n H L 0 A | m protein | peptide NA | NA m48u1 peptide | unknown VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR 08/19/14 Crystal structure of the anti-hiv-1 antibody 2.2c in complex with hiv-1 93ug037 gp120 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 | synthetic construct Acharya, P., Louder, R., Kwong, P.D. 3.56 X-RAY DIFFRACTION 0.328 0.296 False True IGHV4 IGKV1 Kappa None None None None None 6a79 I M 0 B protein roundabout homolog 1 IMMUNE SYSTEM 07/02/18 Crystal structure of the fifth immunoglobulin domain (Ig5) of human Robo1 in complex with the mutant scFv fragment (P103A) of murine monoclonal antibody B5209B HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Mizohata, E., Nakayama, T., Kado, Y., Yokota, Y., Inoue, T. 2.31 X-RAY DIFFRACTION 0.295 0.273 False True IGHV5 IGKV12 Kappa None None None None None 6gkd Q NA 0 O protein cystic fibrosis transmembrane conductance regulator HYDROLASE 05/18/18 human NBD1 of CFTR in complex with nanobodies D12 and G3a HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C. 2.99 X-RAY DIFFRACTION 0.235 0.204 False True IGHV1 None None None None None 5f72 S s 0 K protein kelch-like ech-associated protein 1 DE NOVO PROTEIN 12/07/15 De novo design and crystallographic validation of antibodies targeting a pre-selected epitope HOMO SAPIENS homo sapiens homo sapiens Liu, X., Taylor, R.D., Griffin, L., Coker, S., Adams, R., Ceska, T., Shi, J., Lawson, A.D.G., Baker, T. 1.85 X-RAY DIFFRACTION 0.265 0.223 True True unknown unknown unknown None None None None None 6oe4 B C 0 A protein fusion glycoprotein f0 Viral protein/immune system 03/27/19 Prefusion RSV F monomer bound by neutralizing antibody CR9501 HUMAN RESPIRATORY SYNCYTIAL VIRUS A (STRAIN A2); HOMO SAPIENS homo sapiens homo sapiens human respiratory syncytial virus a (straina2) McLellan, J.S., Gilman, M.S.A. 3.3 X-RAY DIFFRACTION 0.259 0.212 False True IGHV4 IGKV1 Kappa None None None None None 4rfe A B 0 IMMUNE SYSTEM 09/25/14 Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab MACACA MULATTA macaca mulatta macaca mulatta Wu, X., Gohain, N., Tolbert, W.D., Pazgier, M. 1.91 X-RAY DIFFRACTION 0.246 0.192 False True IGHV4 IGLV1 Lambda None None None None None 6h6y E NA 0 A protein capsid protein vp1 VIRAL PROTEIN 12/19/18 GI.1 human norovirus protruding domain in complex with Nano-7 NORWALK VIRUS (STRAIN GI/HUMAN/UNITED STATES/NORWALK/1968); VICUGNA PACOS vicugna pacos norwalk virus (strain gi/human/unitedstates/norwalk/1968) Kilic, T., Ruoff, K., Hansman, G.S. 1.58 X-RAY DIFFRACTION 0.175 0.155 False True IGHV1 None None None None None 3mck B A 0 IMMUNE SYSTEM 03/29/10 Crystal structure of anti-beta-amyloid antibody C705 MUS MUSCULUS mus musculus mus musculus Teplyakov, A., Obmolova, G., Gilliland, G.L. 2.3 X-RAY DIFFRACTION 0.254 0.203 False True IGHV8 IGKV1 Kappa None None None None None 7dcc B M 0 I protein NA spike glycoprotein VIRAL PROTEIN 10/24/20 S-3C1-F3b structure, all the three RBDs are in the up conformation and each of them associates with a 3C1 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Cong, Y., Liu, C.X. 4.3 ELECTRON MICROSCOPY NA NA False False IGHV3 IGKV6 Kappa None None None None None 1um6 H L 0 IMMUNE SYSTEM 09/23/03 catalytic antibody 21h3 MUS MUSCULUS mus musculus mus musculus Beuscher IV, A.E., Reuter, J., Olson, A.J., Romesberg, F.E., Schultz, P.G., Wirsching, P., Janda, K.D., Lerner, R.A., Stevens, R.C. 1.8 X-RAY DIFFRACTION 0.257 0.231 False True IGHV1 IGKV9 Kappa None None None None None 1uz6 P M 0 IMMUNE SYSTEM 03/05/04 anti-Lewis X Fab fragment uncomplexed MUS MUSCULUS mus musculus mus musculus Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P. 2.05 X-RAY DIFFRACTION 0.244 0.198 False False IGHV4 IGKV2 Kappa None None None None None 4o5i Q R 0 E protein hemagglutinin ha1 chain VIRAL PROTEIN/IMMUNE SYSTEM 12/19/13 Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/361/2011 (H3N2) influenza hemagglutinin HOMO SAPIENS; INFLUENZA A VIRUS homo sapiens homo sapiens influenza a virus Lee, P.S., Wilson, I.A. 6.501 X-RAY DIFFRACTION 0.248 0.201 False True IGHV1 IGLV1 Lambda None None None None None 4ocm C NA 0 B | A protein | protein NA | NA 26s proteasome regulatory subunit rpn11 | 26s proteasome regulatory subunit rpn8 HYDROLASE, PROTEIN BINDING 01/09/14 Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form Ib SACCHAROMYCES CEREVISIAE; LAMA GLAMA lama glama saccharomyces cerevisiae | saccharomyces cerevisiae Pathare, G.R., Bracher, A. 1.99 X-RAY DIFFRACTION 0.262 0.216 False True IGHV1 NA NA None None None None None 6gwq B NA 0 A protein plasminogen activator inhibitor-1 HYDROLASE 06/25/18 Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42) HOMO SAPIENS; VICUGNA PACOS vicugna pacos homo sapiens Sillen, M., Weeks, S.D., Strelkov, S.V., Declerck, P.J. 2.32 X-RAY DIFFRACTION 0.230 0.206 False True IGHV1 None None None None None 4hem E NA 0 C | B protein | protein NA | NA bpp | bpp VIRAL PROTEIN 10/04/12 Llama vHH-02 binder of ORF49 (RBP) from lactococcal phage TP901-1 LACTOCOCCUS PHAGE TP901-1; LAMA GLAMA lama glama lactococcus phage tp901-1 | lactococcus phage tp901-1 Desmyter, A., Spinelli, S., Farenc, C., Blangy, S., Bebeacua, C., van Sinderen, D., Mahony, J., Cambillau, C. 1.65 X-RAY DIFFRACTION 0.177 0.167 False True IGHV1 NA NA None None None None None 6o3g H L 0 S peptide meper peptide, region 671-683 of hiv-1 gp41 IMMUNE SYSTEM 02/26/19 Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41). HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 Irimia, A., Wilson, I.A. 3.645 X-RAY DIFFRACTION 0.289 0.260 False True IGHV1 IGKV3 Kappa None None None None None 6o2c A B 0 C peptide NA circumsporozoite protein IMMUNE SYSTEM 02/22/19 Crystal structure of 4493 Fab in complex with circumsporozoite protein NANP3 and anti-kappa VHH domain HOMO SAPIENS; LAMA GLAMA; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Prieto, K., Murugan, R., Wardemann, H., Julien, J.P. 2.017 X-RAY DIFFRACTION 0.195 0.162 False True IGHV3 IGKV3 Kappa None None None None None 4s1d H L 0 H Hapten 41M N~6~-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}-L-lysinamide IMMUNE SYSTEM 01/13/15 Structure of IgG1 Fab fragment in complex with Biotincytidinamide MUS MUSCULUS mus musculus mus musculus mus musculus Dengl, S., Hoffmann, E., Grote, M., Wagner, C., Mundigl, O., Georges, G., Theorey, I., Stubenrauch, K.-G., Bujotzek, A., Josel, H.-P., Dziadek, S., Benz, J., Brinkmann, U. 2.5 X-RAY DIFFRACTION 0.274 0.225 False True IGHV14 IGKV12 Kappa None None None None None 5zud E D 0 C | A | B protein | protein | protein NA | NA | NA vp3 | capsid protein vp1 | vp2 VIRUS LIKE PARTICLE 05/07/18 Fit R10 Fab coordinates into the cryo-EM of EV71 in complex with D6 ENTEROVIRUS A71; MUS MUSCULOIDES mus musculoides mus musculoides enterovirus a71 | enterovirus a71 | enterovirus a71 Wang, X., Zhu, L., Wang, N. 4.9 ELECTRON MICROSCOPY False True IGHV5 IGKV4 Kappa None None None None None 6mhg D Q 0 E protein circumsporozoite protein IMMUNE SYSTEM 09/17/18 Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts PLASMODIUM FALCIPARUM; HOMO SAPIENS homo sapiens homo sapiens plasmodium falciparum Cottrell, C.A., Torres, J.L., Ward, A.B. 3.57 ELECTRON MICROSCOPY False True IGHV3 IGLV1 Lambda None None None None None 5mu2 C D 0 Q peptide synthetic peptide containing the cii583-591 epitope ofcollagen type ii IMMUNE SYSTEM 01/12/17 ACC1 Fab fragment in complex with CII583-591 (CG10) MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Dobritzsch, D., Holmdahl, R., Ge, C. 2.7 X-RAY DIFFRACTION 0.228 0.206 False False IGHV6 IGKV3 Kappa None None None None None 6mei H L 0 C protein e2 glycoprotein IMMUNE SYSTEM 09/06/18 Broadly neutralizing antibodies against HCV use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design HEPACIVIRUS C; HOMO SAPIENS homo sapiens homo sapiens hepacivirus c Flyak, A.I., Bjorkman, P.J. 2.9 X-RAY DIFFRACTION 0.277 0.208 False True IGHV1 IGKV1 Kappa None None None None None 4yhi H L 0 H Hapten 4CC N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine IMMUNE SYSTEM 02/27/15 Reversal Agent for Dabigatran HOMO SAPIENS homo sapiens homo sapiens homo sapiens Schiele, F., Nar, H. 1.9 X-RAY DIFFRACTION 0.215 0.181 False True IGHV1 IGKV1 Kappa None None None None None 6dwi H G 0 H carbohydrate HD4 4-O-[2-acetamido-2-deoxy-beta-D-glucopyranosyl]-1-O-phosphono-D-ribitol IMMUNE SYSTEM 06/26/18 Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog HOMO SAPIENS homo sapiens homo sapiens homo sapiens Fong, R., Lupardus, P.J. 2.39 X-RAY DIFFRACTION 0.249 0.203 False True IGHV3 IGKV3 Kappa None None None None None 7so9 M L 0 K protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 10/29/21 SARS-CoV-2 S B.1.617.2 delta variant + S2M11 + S2L20 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.4 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6opq K N 0 D protein NA envelope glycoprotein gp160 VIRAL PROTEIN/Immune System 04/25/19 CD4- and 17-bound HIV-1 Env B41 SOSIP frozen with LMNG HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Torres, J.L., Ward, A.B. 3.8 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 5tdo D C 0 IMMUNE SYSTEM 09/19/16 Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces HOMO SAPIENS homo sapiens homo sapiens Yin, Y., Carter, P.J. 1.61 X-RAY DIFFRACTION 0.267 0.237 False True IGHV3 IGKV1 Kappa None None None None None 7u0c H L 0 NA NA NA NA ANTIVIRAL PROTEIN,IMMUNE SYSTEM 02/17/22 Crystal structure of broadly neutralizing antibody HEPC3.4 HOMO SAPIENS homo sapiens homo sapiens Flyak, A.I., Bjorkman, P.J. 3.3 X-RAY DIFFRACTION 0.260 0.215 False True IGHV1 IGKV1 Kappa None None None None None 6k5a C D 0 A protein h(+)/cl(-) exchange transporter clca MEMBRANE PROTEIN 05/28/19 Crystal structure of the E148D/R147A/F317A mutant in presence of 200 mM NaBr ESCHERICHIA COLI MS 117-3; MUS MUSCULUS mus musculus mus musculus escherichia coli ms 117-3 Park, K., Lim, H.H. 3.162 X-RAY DIFFRACTION 0.276 0.222 False True IGHV4 IGKV4 Kappa None None None None None 5ikc H L 0 N protein neuronal migration protein doublecortin TRANSFERASE 03/03/16 X-RAY STRUCURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN in complex with FAB HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Ruf, A., Stihle, M., Benz, J., Thoma, R., Rudolph, M.G. 2.06 X-RAY DIFFRACTION 0.265 0.198 False True IGHV14 IGKV6 Kappa 2.7e-08 -10.325467249642376 SPR TBD 4hpo H L 0 P peptide envelope glycoprotein gp160 Immune System/Viral Protein 10/24/12 Crystal structure of RV144-elicited antibody CH58 in complex with V2 peptide HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens human immunodeficiency virus 1 McLellan, J.S., Gorman, J., Haynes, B.F., Kwong, P.D. 1.694 X-RAY DIFFRACTION 0.211 0.185 False True IGHV5 IGLV6 Lambda None None None None None 7l0l I K 0 F | D protein | protein NA | NA hemagglutinin ha2 chain | hemagglutinin ha1 chain IMMUNE SYSTEM/Viral protein 12/11/20 Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer HOMO SAPIENS; INFLUENZA A VIRUS (A/CANADA/720/2005(H2N2)) homo sapiens homo sapiens influenza a virus (a/canada/720/2005(h2n2)) | influenza a virus (a/canada/720/2005(h2n2)) Gorman, J., Kwong, P.D. 2.85 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 6nf2 C D 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 12/18/18 Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Gorman, J., Kwong, P.D. 3.7 ELECTRON MICROSCOPY False True unknown IGKV3 Kappa None None None None None 6e9g A B 0 IMMUNE SYSTEM 08/01/18 The crystal structure of bovine ultralong antibody BOV-2 BOS TAURUS bos taurus bos taurus Dong, J., Crowe, J.E. 2.904 X-RAY DIFFRACTION 0.263 0.220 False True IGHV1 IGLV1 Lambda None None None None None 5kem G H 0 F protein ebola secreted glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 06/09/16 EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91 HOMO SAPIENS; ZAIRE EBOLAVIRUS homo sapiens homo sapiens zaire ebolavirus Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B. 5.5 ELECTRON MICROSCOPY False True IGHV1 IGKV1 Kappa None None None None None 7lxy G I 0 B protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 03/05/21 SARS-CoV-2 S/S2M11/S2X333 Global Refinement SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 McCallum, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV3 Lambda None None None None None 2gsi F E 0 Y peptide thermonuclease IMMUNE SYSTEM 04/26/06 Crystal Structure of a Murine Fab in Complex with an 11 Residue Peptide Derived from Staphylococcal Nuclease MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Armstrong, A.A., Amzel, L.M. 2.81 X-RAY DIFFRACTION 0.293 0.221 False False IGHV14 IGKV3 Kappa None None None None None 6ck9 D E 0 B protein gp41 ectodomain of envelope glycoprotein gp160 VIRAL PROTEIN 02/27/18 Crystal Structure of HIV-1 ConC_Base0 Prefusion Env Trimer in Complex with Human Antibody Fragment 3H109L and 35O22 variants at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.714 X-RAY DIFFRACTION 0.288 0.248 False True unknown unknown unknown None None None None None 5xcv D E 0 F peptide pa14 peptide IMMUNE SYSTEM 03/23/17 Crystal structure of NZ-1 Fv-clasp fragment with its antigen peptide RATTUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT rattus, homo sapiens rattus, homo sapiens homo sapiens Arimori, T., Takagi, J. 2.143 X-RAY DIFFRACTION 0.277 0.228 False True IGHV5 IGLV3 Lambda None None None None None 5xcu A B 0 C peptide ha peptide IMMUNE SYSTEM 03/23/17 Crystal structure of 12CA5 Fv-clasp fragment with its antigen peptide MUS MUSCULUS; HOMO SAPIENS; SYNTHETIC CONSTRUCT mus musculus, homo sapiens mus musculus, homo sapiens homo sapiens Arimori, T., Takagi, J. 2.454 X-RAY DIFFRACTION 0.247 0.199 False True IGHV5 IGKV8 Kappa None None None None None 2wzp K NA 0 G protein putative receptor binding protein VIRAL PROTEIN 12/01/09 Structures of Lactococcal Phage p2 Baseplate Shed Light on a Novel Mechanism of Host Attachment and Activation in Siphoviridae LACTOCOCCUS PHAGE P2; LAMA GLAMA lama glama lactococcus phage p2 Sciara, G., Bebeacua, C., Bron, P., Tremblay, D., Ortiz-Lombardia, M., Lichiere, J., van Heel, M., Campanacci, V., Moineau, S., Cambillau, C. 2.6 X-RAY DIFFRACTION 0.2078 0.1789 False True IGHV1 None None None None None 7kn3 H L 0 A protein NA spike protein s1 VIRAL PROTEIN/IMMUNE SYSTEM 11/04/20 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-B8 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Liu, H., Zhu, X., Wilson, I.A. 2.251 X-RAY DIFFRACTION 0.222 0.186 False True IGHV3 IGKV4 Kappa None None None None None 6dfh I K 0 D protein envelope glycoprotein gp160 VIRAL PROTEIN/IMMUNE SYSTEM 05/14/18 BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Ozorowski, G., Steichen, J.M., Schief, W.R., Ward, A.B. 3.85 ELECTRON MICROSCOPY False True IGHV4 IGLV3 Lambda None None None None None 5umi H L 0 C protein NA toxin a TOXIN/IMMUNE SYSTEM 01/27/17 Clostridium difficile TcdA-CROPs bound to PA50 Fab CLOSTRIDIOIDES DIFFICILE; HOMO SAPIENS homo sapiens homo sapiens clostridioides difficile Kroh, H.K., Chandrasekaran, R., Rosenthal, K., Woods, R., Jin, X., Ohi, M.D., Nyborg, A.C., Rainey, G.J., Warrener, P., Spiller, B.W., Lacy, D.B. 3.23 X-RAY DIFFRACTION 0.290 0.270 False True IGHV1 IGKV3 Kappa None None None None None 2kh2 B b 58 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 5d93 F E 0 D protein sulfhydryl oxidase 1 OXIDOREDUCTASE 08/18/15 Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from a Mouse QSOX1-Specific Antibody MUS MUSCULUS mus musculus mus musculus mus musculus Grossman, I., Fass, D. 2.201 X-RAY DIFFRACTION 0.236 0.174 False True IGHV1 IGKV4 Kappa None None None None None 6o8d NA L 0 NA NA NA NA IMMUNE SYSTEM 03/09/19 Anti-CD28xCD3 CODV Fab bound to CD28 HOMO SAPIENS homo sapiens Lord, D.M., Wei, R.R. 3.547 X-RAY DIFFRACTION 0.356 0.272 False True NA IGKV15 Kappa None None None None None 1oar I M 0 I Hapten AZN ALIZARIN RED IMMUNE SYSTEM 01/21/03 Fv IgE SPE-7 in complex with Alizarin Red RATTUS RATTUS rattus rattus rattus rattus rattus rattus James, L.C., Roversi, P., Tawfik, D. 2.23 X-RAY DIFFRACTION 0.241 0.205 False True IGHV1 IGLV1 Lambda 4.00e-08 Other 20 12610298 6mid H L 0 E | C protein | protein NA | NA e protein | e protein VIRUS/IMMUNE SYSTEM 09/19/18 Cryo-EM structure of the ZIKV virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195 ZIKA VIRUS (ISOLATE ZIKV/HUMAN/FRENCH POLYNESIA/10087PF/2013); HOMO SAPIENS homo sapiens homo sapiens zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) | zika virus (isolate zikv/human/frenchpolynesia/10087pf/2013) Long, F., Rossmann, M.G. 4 ELECTRON MICROSCOPY False False IGHV3 IGLV1 Lambda None None None None None 5n2k D C 0 IMMUNE SYSTEM 02/07/17 Structure of unbound Briakinumab FAb HOMO SAPIENS homo sapiens homo sapiens Bloch, Y., Savvides, S.N. 2.219 X-RAY DIFFRACTION 0.234 0.204 False True IGHV3 IGLV1 Lambda None None None None None 3u2s A B 0 C protein envelope glycoprotein gp120 IMMUNE SYSTEM 10/04/11 Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain ZM109 HOMO SAPIENS; HUMAN IMMUNODEFICIENCY VIRUS 1 homo sapiens homo sapiens human immunodeficiency virus 1 McLellan, J.S., Pancera, M., Kwong, P.D. 1.797 X-RAY DIFFRACTION 0.205 0.178 False True IGHV3 IGLV2 Lambda None None None None None 6oge C B 0 A protein receptor tyrosine-protein kinase erbb-2 transferase/immune system 04/02/19 Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hao, Y., Yu, X., Bai, Y., Huang, X. 4.36 ELECTRON MICROSCOPY False True IGHV3 IGKV1 Kappa None None None None None 6t3f H L 0 F protein fusion glycoprotein f0 VIRAL PROTEIN 10/10/19 Crystal structure Nipah virus fusion glycoprotein in complex with a neutralising Fab fragment NIPAH VIRUS; ORYCTOLAGUS CUNICULUS oryctolagus cuniculus oryctolagus cuniculus nipah virus Avanzato, V.A., Pryce, R., Walter, T.S., Bowden, T.A. 3.2 X-RAY DIFFRACTION 0.249 0.213 False True IGHV1 IGKV1 Kappa None None None None None 3piq G I 0 IMMUNE SYSTEM 11/07/10 Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1 HOMO SAPIENS homo sapiens homo sapiens Changela, A., Gorny, M.K., Zolla-Pazner, S., Kwong, P.D. 3.325 X-RAY DIFFRACTION 0.299 0.236 False True IGHV3 IGLV3 Lambda None None None None None 3ria J M 0 E protein avermectin-sensitive glutamate-gated chloride channel gluclalpha TRANSPORT PROTEIN/IMMUNE SYSTEM 04/13/11 C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. CAENORHABDITIS ELEGANS; MUS MUSCULUS mus musculus mus musculus caenorhabditis elegans Hibbs, R.E., Gouaux, E. 3.8 X-RAY DIFFRACTION 0.280 0.266 False True IGHV1 IGLV1 Lambda None None None None None 7n3d H L 0 C protein NA nucleoprotein VIRAL PROTEIN 05/31/21 Crystal Structure of Human Fab S24-1564 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Kim, Y., Maltseva, N., Tesar, C., Jedrzejczak, R., Dugan, H., Stamper, C., Wilson, P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID) 1.53 X-RAY DIFFRACTION 0.190 0.157 False True IGHV4 IGKV1 Kappa None None None None None 4od2 B A 0 S protein tumor necrosis factor receptor superfamily member 10b APOPTOSIS/IMMUNE SYSTEM 01/09/14 Crystal structure of the Fab fragment of an anti-DR5 antibody bound to DR5 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Hymowitz, S.G., Compaan, D. 3.2 X-RAY DIFFRACTION 0.305 0.241 False True IGHV3 IGLV3 Lambda 9.200000000000001e-10 -12.327599047200819 Saturation Analysis TBD 7rp3 H I 0 A protein NA isoform 2b of gtpase kras Hydrolase/Immune System 08/03/21 Crystal structure of GNE-1952 alkylated KRAS G12C in complex with 2H11 CLAMP HOMO SAPIENS homo sapiens homo sapiens homo sapiens Oh, A., Tam, C., Wang, W. 2.0 X-RAY DIFFRACTION 0.234 0.191 False True IGHV4 IGLV1 Lambda None None None None None 1dn0 D C 0 IMMUNE SYSTEM 12/15/99 STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ HOMO SAPIENS homo sapiens homo sapiens Cauerhff, A., Braden, B., Carvalho, J.G., Leoni, J., Polikarpov, I., Goldbaum, F. 2.28 X-RAY DIFFRACTION 0.240 0.180 False False IGHV4 IGKV3D Kappa None None None None None 3ln9 A NA 0 IMMUNE SYSTEM 02/02/10 Crystal structure of the fibril-specific B10 antibody fragment CAMELIDAE camelidae Parthier, C., Morgado, I., Stubbs, M.T., Faendrich, M. 1.8 X-RAY DIFFRACTION 0.233 0.197 False True IGHV1 None None None None None 7a25 F NA 0 C protein NA spike glycoprotein VIRAL PROTEIN 08/16/20 Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; SYNTHETIC CONSTRUCT synthetic construct severe acute respiratory syndrome coronavirus2 Hallberg, B.M., Das, H. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 1ots C D 0 A protein voltage-gated clc-type chloride channel eric MEMBRANE PROTEIN 03/22/03 Structure of the Escherichia coli ClC Chloride channel and Fab Complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Dutzler, R., Campbell, E.B., MacKinnon, R. 2.51 X-RAY DIFFRACTION 0.299 0.264 False False IGHV4 IGKV4 Kappa None None None None None 7zmm F NA 0 B protein NA atp-dependent dna helicase q5 HYDROLASE 04/19/22 Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2-001 Homo sapiens; Lama glama lama glama homo sapiens Ye, M., Makola, M., Newman, J.A., Fairhead, M., MacLean, E., Krojer, T., Aitkenhead, H., Bountra, C., Gileadi, O., von Delft, F. 2.5 X-RAY DIFFRACTION 0.281 0.240 False True IGHV1 NA NA None None None None None 5hys C D 0 K protein ig epsilon chain c region IMMUNE SYSTEM 02/01/16 Structure of IgE complexed with omalizumab HOMO SAPIENS homo sapiens homo sapiens homo sapiens Pennington, L.F., Tarchevskaya, S.S., Sathiyamoorthy, K., Jardetzky, T.S. 2.5 X-RAY DIFFRACTION 0.239 0.221 False True IGHV3 IGKV1 Kappa 3.8899999999999996e-11 -14.201849726854265 SPR TBD 2kh2 B b 67 A protein interleukin-1 beta Cytokine/IMMUNE SYSTEM 03/23/09 Solution structure of a scFv-IL-1B complex HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D. NOT SOLUTION NMR True True unknown unknown unknown None None None None None 1maj NA A 12 IMMUNOGLOBULIN 09/16/93 SOLUTION STRUCTURE OF AN ISOLATED ANTIBODY VL DOMAIN MUS MUSCULUS mus musculus Constantine, K.L., Friedrichs, M.S., Metzler, W.J., Wittekind, M., Hensley, P., Mueller, L. NOT SOLUTION NMR False True unknown unknown unknown None None None None None 2hlf C D 0 A protein h(+)/cl(-) exchange transporter clca PROTON TRANSPORT,MEMBRANE PROTEIN 07/07/06 Structure of the Escherichis coli ClC chloride channel Y445E mutant and Fab complex ESCHERICHIA COLI; MUS MUSCULUS mus musculus mus musculus escherichia coli Accardi, A., Lobet, S., Williams, C., Miller, C., Dutzler, R. 3.3 X-RAY DIFFRACTION 0.309 0.281 False False IGHV4 IGKV4 Kappa None None None None None 4cau D d 0 C protein envelope protein e VIRUS 10/09/13 THREE-DIMENSIONAL STRUCTURE OF DENGUE VIRUS SEROTYPE 1 COMPLEXED WITH 2 HMAB 14C10 FAB DENGUE VIRUS 1; HOMO SAPIENS homo sapiens dengue virus 1 TEOH, E.P., KUKKARO, P., TEO, E.W., LIM, A.P., TAN, T.T., YIP, A., SCHUL, W., AUNG, M., KOSTYUCHENKO, V.A., LEO, Y.S., CHAN, S.H., SMITH, K.G., CHAN, A.H., ZOU, G., OOI, E.E., KEMENY, D.M., TAN, G.K., NG, J.K., NG, M.L., ALONSO, S., FISHER, D., SHI, P.Y., HANSON, B.J., LOK, S.M., MACARY, P.A. 7.0 ELECTRON MICROSCOPY True True unknown unknown unknown None None None None None 3ijy D C 0 D carbohydrate KDA polysaccharide IMMUNE SYSTEM 08/05/09 Structure of S67-27 in Complex with Kdo(2.8)Kdo MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus mus musculus Brooks, C.L., Blackler, R.J., Evans, S.V. 2.85 X-RAY DIFFRACTION 0.284 0.237 False False IGHV7 IGKV8 Kappa 9.1e-07 -8.241342074897947 Unknown TBD 6adc C D 0 A protein h(+)/cl(-) exchange transporter clca TRANSPORT PROTEIN 07/31/18 Crystal structure of the E148A mutant CLC-ec1 in the presence of 50mM bromoacetate ESCHERICHIA COLI (STRAIN K12); MUS MUSCULUS mus musculus mus musculus escherichia coli (strain k12) Lim, H.-H., Park, K. 3.055 X-RAY DIFFRACTION 0.275 0.226 False False IGHV4 IGKV4 Kappa None None None None None 3q1s H L 0 I protein interleukin-22 IMMUNE SYSTEM/CYTOKINE 12/17/10 HIV-1 neutralizing antibody Z13e1 in complex with epitope display protein HOMO SAPIENS homo sapiens homo sapiens homo sapiens Stanfield, R.L., Julien, J.-P., Pejchal, R., Gach, J.S., Zwick, M.B., Wilson, I.A. 2.15 X-RAY DIFFRACTION 0.260 0.207 False True IGHV4 IGKV3D Kappa 7.30E-08 -9.85 ITC 25 22033480 6n35 H L 0 H carbohydrate MAN polysaccharide IMMUNE SYSTEM 11/14/18 Anti-HIV-1 Fab 2G12 + Man1-2 re-refinement HOMO SAPIENS homo sapiens homo sapiens homo sapiens Calarese, D.A., Stanfield, R.L., Wilson, I.A. 1.747 X-RAY DIFFRACTION 0.238 0.207 False True unknown IGKV1 Kappa None None None None None 7l6m i j 0 NA NA NA NA IMMUNE SYSTEM 12/23/20 Cryo-EM structure of DH898.1 Fab-dimer from local refinement of the Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer MACACA MULATTA macaca mulatta macaca mulatta Manne, K., Edwards, R.J., Acharya, P. 4.7 ELECTRON MICROSCOPY NA NA False False unknown IGKV2 Kappa None None None None None 4bel E NA 0 B protein beta-secretase 2 HYDROLASE/IMMUNE SYSTEM 03/11/13 BACE2 XAPERONE COMPLEX HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Banner, D.W., Kuglstatter, A., Benz, J., Stihle, M., Ruf, A. 1.85 X-RAY DIFFRACTION 0.22234 0.18130 False True IGHV3 None None None None None 6wer C D 0 A protein NA non-structural protein 1 VIRAL PROTEIN 04/02/20 DENV2 NS1 in complex with neutralizing 2B7 Fab fragment DENGUE VIRUS 2; MUS MUSCULUS mus musculus mus musculus dengue virus 2 Akey, D.L., Smith, J.L. 3.96 X-RAY DIFFRACTION 0.311 0.276 False False IGHV1 IGKV3 Kappa None None None None None 6igu H L 0 IMMUNE SYSTEM 09/26/18 Crystal structure of the hydrolytic antibody Fab 9C10 MUS MUSCULUS mus musculus mus musculus Yamaguchi, A., Tada, T., Tsuchiya, Y., Tsumuraya, T., Fujii, I. 2.11 X-RAY DIFFRACTION 0.237 0.175 False False IGHV5 IGKV1 Kappa None None None None None 4xak H L 0 A protein spike glycoprotein IMMUNE SYSTEM 12/15/14 Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD HUMAN CORONAVIRUS EMC; HOMO SAPIENS homo sapiens homo sapiens human coronavirus emc Zhou, T., Dimtrov, D.S., Ying, T. 2.45 X-RAY DIFFRACTION 0.249 0.198 False True IGHV1 IGKV1 Kappa None None None None None 3cm9 A L 0 IMMUNE SYSTEM 03/21/08 Solution Structure of Human SIgA2 HOMO SAPIENS homo sapiens homo sapiens Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. NOT SOLUTION SCATTERING False False IGHV1 IGKV1 Kappa None None None None None 6mqs A B 0 E peptide hiv fusion peptide residue 512-519 IMMUNE SYSTEM 10/10/18 Vaccine-elicited NHP FP-targeting HIV neutralizing antibody A12V163-a.01 in complex with HIV fusion peptide (residue 512-519) PLATYRRHINI; SYNTHETIC CONSTRUCT platyrrhini platyrrhini human immunodeficiency virus 1 Xu, K., Wang, Y., Kwong, P.D. 2.997 X-RAY DIFFRACTION 0.247 0.233 False True IGHV4 IGLV1 Lambda None None None None None 7kh0 S s 0 A protein NA guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion SIGNALING PROTEIN 10/19/20 Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling complex HOMO SAPIENS; LAMA GLAMA homo sapiens homo sapiens Wang, L., Xu, J., Gao, S., Sun, D., Liu, H., Liu, Z., Du, Y., Zhang, C. 2.8 ELECTRON MICROSCOPY NA NA True True unknown unknown unknown None None None None None 5drx A B 0 IMMUNE SYSTEM 09/16/15 Crystal structure of the BCR Fab fragment from subset #4 case CLL240 HOMO SAPIENS homo sapiens homo sapiens Minici, C., Degano, M. 2.104 X-RAY DIFFRACTION 0.222 0.194 False True IGHV4 IGKV2 Kappa None None None None None 5y9f V U 0 F protein NA major capsid protein l1 VIRAL PROTEIN/IMMUNE SYSTEM 08/24/17 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 HUMAN PAPILLOMAVIRUS TYPE 59; MUS MUSCULUS mus musculus mus musculus human papillomavirus type 59 Li, S.W., Li, Z.H. 3.35 X-RAY DIFFRACTION 0.261 0.230 False False IGHV5 IGKV1 Kappa None None None None None 7a48 A NA 0 B peptide NA aph colied-coil DE NOVO PROTEIN 08/19/20 Crystal structure of the APH coiled-coil in complex with Nb49 LAMA GLAMA; SYNTHETIC CONSTRUCT lama glama synthetic construct Hadzi, S. 1.547 X-RAY DIFFRACTION 0.212 0.179 False True IGHV1 NA NA None None None None None 6vi2 D C 0 NA NA NA NA IMMUNE SYSTEM 01/11/20 Structure of the unaligned Fab4 HOMO SAPIENS homo sapiens homo sapiens Cingolani, G., Lokareddy, R., Ko, Y. 1.15 X-RAY DIFFRACTION 0.171 0.158 False True IGHV3 IGKV1 Kappa None None None None None 1ohq A NA 0 IMMUNOGLOBULIN 05/30/03 Crystal structure of HEL4, a soluble human VH antibody domain resistant to aggregation HOMO SAPIENS homo sapiens Jespers, L., Schon, O., James, L.C., Veprintsev, D., Winter, G. 2.0 X-RAY DIFFRACTION 0.26 0.182 False True IGHV3 None None None None None 2p48 B NA 0 A protein ribonuclease pancreatic HYDROLASE/IMMUNE SYSTEM 03/11/07 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.3A resolution: SE5B-tetra crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. CAMELUS DROMEDARIUS; BOS TAURUS camelus dromedarius bos taurus Tereshko, V., Uysal, S., Koide, A., Margalef, K., Koide, S., Kossiakoff, A.A. 2.3 X-RAY DIFFRACTION 0.297 0.241 False True IGHV1 1.16e-07 -9.61 Other 30 18445622 6ju0 K O 0 IMMUNE SYSTEM 04/12/19 Mouse antibody 3.3 Fab in complex with PEG MUS MUSCULUS mus musculus mus musculus Lee, C.C., Ko, T.P., Lin, L.L., Wang, A.H.J. 2.601 X-RAY DIFFRACTION 0.240 0.211 False True IGHV6 IGKV4 Kappa None None None None None 6dc8 H L 0 P peptide microtubule-associated protein tau IMMUNE SYSTEM 05/04/18 Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope. MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus homo sapiens Chukwu, J.E., Kong, X.-P. 1.799 X-RAY DIFFRACTION 0.219 0.179 False False IGHV1 IGKV1 Kappa None None None None None 4zfg H L 0 A protein angiopoietin-2 SIGNALING PROTEIN/IMMUNE SYSTEM 04/21/15 Dual-specificity Fab 5A12 in complex with Angiopoietin 2 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Harris, S.F., Wu, P. 2.27 X-RAY DIFFRACTION 0.223 0.177 False True IGHV3 IGKV1 Kappa 5e-09 -11.324631107601816 SPR TBD 5dmj B NA 0 A protein tumor necrosis factor receptor superfamily member 5 IMMUNE SYSTEM/SIGNALING PROTEIN 09/08/15 Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB HOMO SAPIENS homo sapiens homo sapiens Sheriff, S. 2.79 X-RAY DIFFRACTION 0.258 0.229 False True IGHV3 5.3e-09 -11.290107730486941 SPR TBD 7cvy I J 0 G protein NA e2 glycoprotein IMMUNE SYSTEM/VIRUS 08/27/20 Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124 MUS MUSCULUS; CHIKUNGUNYA VIRUS mus musculus mus musculus chikungunya virus Zhou, Q.F., Fox, J.M., Earnest, J.T., Ng, T.S., Kim, A.S., Fibriansah, G., Kostyuchenko, V.A., Shu, B., Diamond, M.S., Lok, S.M. 5.2 ELECTRON MICROSCOPY NA NA False False IGHV6 IGKV6 Kappa None None None None None 6yo6 C NA 0 B | A protein | protein NA | NA ic3b1 beta chain | ic3b1 alpha chain IMMUNE SYSTEM 04/14/20 Structure of iC3b1 LAMA GLAMA; HOMO SAPIENS lama glama homo sapiens | homo sapiens Jensen, R.K., Andersen, G.R. 6.0 X-RAY DIFFRACTION 0.266 0.241 False True IGHV1 NA NA None None None None None 5vyf H L 0 F protein chimera of major allergen i polypeptide chain 2,majorallergen i polypeptide chain 1 IMMUNE SYSTEM 05/25/17 Structure of single chain Fel d 1 bound to a neutralizing antibody MUS MUSCULUS; FELIS CATUS mus musculus mus musculus felis catus Franklin, M.C. 2.9 X-RAY DIFFRACTION 0.259 0.225 False True IGHV3 IGKV1 Kappa 1.87e-10 -13.271582589129338 SPR TBD 7k7h H L 0 A | C | G protein | protein | peptide NA | NA | NA pertussis like toxin subunit b | pertussis like toxin subunit b | pertussis toxin-like subunit arta TOXIN 09/22/20 Density-fitted Model Structure of Antibody Variable Domains of TyTx1 in Complex with PltB pentamer of Typhoid Toxin SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHI STR. CT18; MUS MUSCULUS mus musculus mus musculus salmonella enterica subsp. enterica serovartyphi str. ct18 | salmonella enterica subsp. enterica serovartyphi str. ct18 | salmonella enterica subsp. enterica serovartyphi str. ct18 Nguyen, T., Feathers, J.R., Fromme, J.C., Song, J. 3 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV8 Kappa None None None None None 5mp5 C D 0 IMMUNE SYSTEM 12/15/16 Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5 MUS MUSCULUS; SYNTHETIC CONSTRUCT mus musculus mus musculus Skrabana, R., Novak, M. 2.31 X-RAY DIFFRACTION 0.277 0.235 False False IGHV1 IGKV8 Kappa None None None None None 7wpe Z NA 0 NA NA NA NA VIRAL PROTEIN 01/23/22 SARS-CoV-2 Omicron Variant S Trimer complexed with two JMB2002 Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS; LAMA GLAMA lama glama Yin, W., Xu, Y., Xu, P., Cao, X., Wu, C., Gu, C., He, X., Wang, X., Huang, S., Yuan, Q., Wu, K., Hu, W., Huang, Z., Liu, J., Wang, Z., Jia, F., Xia, K., Liu, P., Wang, X., Song, B., Zheng, J., Jiang, H., Cheng, X., Jiang, Y., Deng, S.J., Xu, H.E. 2.69 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 7p5v I NA 0 C protein NA volume-regulated anion channel subunit lrrc8a MEMBRANE PROTEIN 07/15/21 Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1 MUS MUSCULUS; SYNTHETIC CONSTRUCT synthetic construct mus musculus Deneka, D., Rutz, S., Sawicka, M. 3.06 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4rdq I H 0 A protein bestrophin-1 TRANSPORT PROTEIN 09/19/14 Calcium-activated chloride channel bestrophin-1, from chicken, in complex with Fab antibody fragments, chloride and calcium GALLUS GALLUS; MUS MUSCULUS mus musculus mus musculus gallus gallus Dickson, V.K., Pedi, L., Long, S.B. 2.85 X-RAY DIFFRACTION 0.234 0.217 False False IGHV1 IGKV12 Kappa 1.5000000000000002e-08 -10.67372125591851 Unknown TBD 6y1l H L 0 L Hapten DEP DIETHYL PHOSPHONATE IMMUNE SYSTEM 02/12/20 Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - L47R mutant HOMO SAPIENS homo sapiens homo sapiens homo sapiens Chatziefthimiou, S., Mokrushina, Y., Smirnov, I., Gabibov, A., Wilmanns, M. 1.4 X-RAY DIFFRACTION 0.200 0.171 False True IGHV4 IGLV1 Lambda None None None None None 7zrc J K 0 A protein NA spike glycoprotein,fibritin STRUCTURAL PROTEIN 05/04/22 OMI-38 FAB IN COMPLEX WITH SARS-COV-2 BETA SPIKE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; ENTEROBACTERIA PHAGE T4; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2, enterobacteria phage t4 Duyvesteyn, H.M.E., Ren, J., Stuart, D.I. 3.5 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 5it2 H L 0 IMMUNE SYSTEM 03/16/16 Structure of a transglutaminase 2-specific autoantibody 693-10-B06 Fab fragment HOMO SAPIENS homo sapiens homo sapiens Chen, X., Dalhus, B., Hnida, K., Iversen, R., Sollid, L.M. 1.7 X-RAY DIFFRACTION 0.204 0.185 False True IGHV5 IGKV1 Kappa None None None None None 5sy8 H L 0 O protein 10e8 epitope scaffold t117v2 IMMUNE SYSTEM 08/10/16 Crystal structure of the complex of 10E8 Fab light chain mutant1 and T117v2 HIV-1 MPER scaffold HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens synthetic construct Irimia, A., Wilson, I.A. 1.62 X-RAY DIFFRACTION 0.214 0.172 False True IGHV3 IGLV3 Lambda 1.1199999999999999e-11 -14.939539586992543 SPR TBD 3idx H L 0 G protein hiv-1 hxbc2 gp120 core IMMUNE SYSTEM 07/22/09 Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C222 HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Chen, L., Kwon, Y.D., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A.J., Pancera, M., Tang, M., Xu, L., Yang, Z.Y., Zhang, M.Y., Arthos, J., Burton, D.R., Dimitrov, D.S., Nabel, G.J., Posner, M., Sodroski, J., Wyatt, R., Mascola, J.R., Kwong, P.D. 2.5 X-RAY DIFFRACTION 0.239 0.178 False True IGHV3 IGKV1 Kappa 4.04e-09 -11.450944611411623 SPR TBD 1mcn NA B 0 P peptide peptide n-acetyl-d-his-l-pro-nh2 IMMUNE SYSTEM 02/25/93 PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS HOMO SAPIENS homo sapiens Edmundson, A.B., Harris, D.L., Fan, Z.-C., Guddat, L.W. 2.7 X-RAY DIFFRACTION unknown 0.183 False True IGLV2 Lambda None None None None None 6lbh E F 0 A protein NA magnesium transporter mgte TRANSPORT PROTEIN/IMMUNE SYSTEM 11/14/19 Cryo-EM structure of the MgtE Mg2+ channel under Mg2+-free conditions THERMUS THERMOPHILUS HB8; MUS MUSCULUS mus musculus mus musculus thermus thermophilus hb8 Hattori, M., Jin, F. 3.7 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV1 Kappa None None None None None 6ban F E 0 O protein NA inactive tyrosine-protein kinase transmembrane receptorror1 IMMUNE SYSTEM 10/14/17 Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1 HOMO SAPIENS homo sapiens homo sapiens homo sapiens Park, H., Rader, C. 1.95 X-RAY DIFFRACTION 0.196 0.160 False True IGHV1 IGKV1 Kappa None None None None None 2kqm NA A 19 IMMUNE SYSTEM 11/11/09 Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Volkman, B.F., Peterson, F.C., Ramirez-Alvarado, M., Baden, E.M. NOT SOLUTION NMR False True IGKV1 Kappa None None None None None 6nnf U V 0 G protein envelope glycoprotein gp120 IMMUNE SYSTEM 01/14/19 Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to VRC01 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.5 Angstrom HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Lai, Y.-T., Kwong, P.D. 2.762 X-RAY DIFFRACTION 0.298 0.242 False True unknown unknown unknown None None None None None 6ol7 C B 0 IMMUNE SYSTEM 04/15/19 Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv MUS MUSCULUS; HOMO SAPIENS homo sapiens homo sapiens Weidle, C., Pancera, M. 2.419 X-RAY DIFFRACTION 0.224 0.174 False True IGHV1 IGKV3 Kappa None None None None None 5wts A NA 0 LIGASE/LIGASE INHIBITOR 12/14/16 Green fluorescent protein linked peptide inhibitor PMI in complex with mdm2 AEQUOREA VICTORIA; HOMO SAPIENS aequorea victoria Wongsantichon, J., Robinson, R.C., Ghadessy, F.J. 3.004 X-RAY DIFFRACTION 0.244 0.204 False True IGHV1 None None None None None 3p0v H L 0 IMMUNE SYSTEM 09/29/10 anti-EGFR/HER3 Fab DL11 alone HOMO SAPIENS homo sapiens homo sapiens Eigenbrot, C., Shia, S. 2.85 X-RAY DIFFRACTION 0.280 0.227 False True IGHV3 IGKV1 Kappa None None None None None 4mqt B NA 0 A protein NA muscarinic acetylcholine receptor m2 SIGNALING PROTEIN 09/16/13 Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620 HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K. 3.7 X-RAY DIFFRACTION 0.301 0.250 False True IGHV1 NA NA None None None None None 7wd7 e f 0 C protein NA heavy chain of s5d2 fab VIRAL PROTEIN 12/21/21 SARS-CoV-2 Beta spike in complex with three S5D2 Fabs SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; MUS MUSCULUS mus musculus mus musculus severe acute respiratory syndrome coronavirus2 Wang, Y.F., Cong, Y. 3.5 ELECTRON MICROSCOPY NA NA False False IGHV1 IGKV8 Kappa None None None None None 4ps4 H L 0 A protein interleukin-13 IMMUNE SYSTEM 03/06/14 Crystal structure of the complex between IL-13 and M1295 FAB HOMO SAPIENS homo sapiens homo sapiens homo sapiens Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. 2.8 X-RAY DIFFRACTION 0.271 0.211 False True IGHV2 IGKV3D Kappa 5.7e-12 -15.339731268738026 SPR TBD 5jw4 S T 0 H | G protein | protein NA | NA hemagglutinin | hemagglutinin IMMUNE SYSTEM 05/11/16 Structure of MEDI8852 Fab Fragment in Complex with H5 HA INFLUENZA A VIRUS; HOMO SAPIENS homo sapiens homo sapiens influenza a virus | influenza a virus Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J. 3.7 X-RAY DIFFRACTION 0.285 0.274 False True IGHV6 IGKV1 Kappa None None None None None 7jvb D NA 0 B protein NA spike glycoprotein VIRAL PROTEIN 08/20/20 Crystal structure of the SARS-CoV-2 spike receptor-binding domain (RBD) with nanobody Nb20 SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; LAMA GLAMA lama glama severe acute respiratory syndrome coronavirus2 Xiang, Y., Xiao, Z., Liu, H., Sang, Z., Schneidman-Duhovny, D., Zhang, C., Shi, Y. 3.287 X-RAY DIFFRACTION 0.322 0.281 False True IGHV1 NA NA None None None None None 1ct8 D C 0 D Hapten TAA [4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]-PHOSPHONIC ACID MONO-[2-(2,2-DICHLORO-1-HYDROXY-ETHYLAMINO)-3-HYDROXY-1-(4-NITRO-PHENYL)-PROPYL] ESTER IMMUNE SYSTEM 08/20/99 CATALYTIC ANTIBODY 7C8 COMPLEX MUS MUSCULUS mus musculus mus musculus mus musculus Gigant, B., Tsumuraya, T., Fujii, I., Knossow, M. 2.2 X-RAY DIFFRACTION 0.275 0.211 False False IGHV1 IGKV5 Kappa 3e-07 -8.898798774188476 Unknown TBD 5kvd H L 0 E protein zika envelope diii VIRAL PROTEIN/IMMUNE SYSTEM 07/14/16 Zika specific antibody, ZV-2, bound to ZIKA envelope DIII ZIKA VIRUS; MUS MUSCULUS mus musculus mus musculus zika virus Zhao, H., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID) 1.65 X-RAY DIFFRACTION 0.221 0.190 False False IGHV1 IGKV8 Kappa 2.66e-07 -8.97006636439889 SPR TBD 2x89 B NA 0 F protein beta-2-microglobulin IMMUNE SYSTEM 03/07/10 Structure of the Beta2_microglobulin involved in amyloidogenesis HOMO SAPIENS; CAMELUS DROMEDARIUS homo sapiens homo sapiens Domanska, K., Srinivasan, V., Vanderhaegen, S., Pardon, E., Marquez, J.A., Bellotti, V., Wyns, L., Steyaert, J. 2.16 X-RAY DIFFRACTION 0.26691 0.23813 False True IGHV3 4.40e-08 -10.03 SPR 21220305 7mzj N M 0 B protein NA spike protein s1 VIRAL PROTEIN 05/24/21 SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 93 HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Pymm, P., Dietrich, M.H., Tan, L.L., Chan, L.J., Tham, W.H. 2.4 X-RAY DIFFRACTION 0.268 0.222 False True IGHV3 IGKV1 Kappa None None None None None 5uoe V W 0 E protein insulin-degrading enzyme Hydrolase/Immune System 01/31/17 Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) HOMO SAPIENS homo sapiens homo sapiens homo sapiens Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J. 3.8 X-RAY DIFFRACTION 0.270 0.220 False True IGHV3 IGKV1 Kappa None None None None None 3ncj H L 0 IMMUNE SYSTEM 06/04/10 Crystal structure of Fab15 Mut8 HOMO SAPIENS homo sapiens homo sapiens Luo, J., Feng, Y., Gilliland, G.L. 1.6 X-RAY DIFFRACTION 0.225 0.200 False True IGHV5 IGKV1 Kappa None None None None None 7e14 N NA 0 A | B protein | protein NA | NA gs | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 MEMBRANE PROTEIN 01/30/21 Compound2_GLP-1R_OWL833_Gs complex structure HOMO SAPIENS; BOS TAURUS; RATTUS NORVEGICUS; SYNTHETIC CONSTRUCT synthetic construct homo sapiens | bos taurus Cong, Z.T., Chen, L.N., Ma, H.L., Yang, D.H., Xu, H.E., Zhang, Y., Wang, M.W. 2.9 ELECTRON MICROSCOPY NA NA False True IGHV3 NA NA None None None None None 7wlw H L 0 A protein NA sodium-dependent dopamine transporter MEMBRANE PROTEIN 01/13/22 X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in complex with SKF89976a Drosophila melanogaster; Mus musculus mus musculus mus musculus drosophila melanogaster Penmatsa, A., Joseph, D. 2.9 X-RAY DIFFRACTION 0.264 0.235 False True IGHV5 IGKV4 Kappa None None None None None 5yax B b 0 C peptide large envelope protein IMMUNE SYSTEM 09/02/17 Crystal structure of a human neutralizing antibody bound to a HBV preS1 peptide HOMO SAPIENS; HEPATITIS B VIRUS homo sapiens hepatitis b virus Liu, X., Zheng, S., Ye, K., Sui, J. 2.5 X-RAY DIFFRACTION 0.288 0.242 True True unknown unknown unknown None None None None None 3cdf NA D 0 IMMUNE SYSTEM 02/26/08 kI O18/O8 Y87H immunoglobulin light chain variable domain HOMO SAPIENS homo sapiens Baden, E.M., Randles, E.G., Thompson, J.R., Ramirez-Alvarado, M. 1.53 X-RAY DIFFRACTION 0.231 0.189 False True IGKV1 Kappa None None None None None 7epb D NA 0 B protein NA metabotropic glutamate receptor 2 MEMBRANE PROTEIN 04/26/21 Cryo-EM structure of LY354740-bound mGlu2 homodimer HOMO SAPIENS; LAMA GLAMA lama glama homo sapiens Du, J., Wang, D., Fan, H., Tai, L., Lin, S., Han, S., Sun, F., Wu, B., Zhao, Q. 3.1 ELECTRON MICROSCOPY NA NA False True IGHV1 NA NA None None None None None 4fql H L 0 IMMUNE SYSTEM 06/25/12 Influenza B HA Antibody (Fab) CR8033 HOMO SAPIENS homo sapiens homo sapiens Dreyfus, C., Laursen, N.S., Wilson, I.A. 1.898 X-RAY DIFFRACTION 0.231 0.194 False True IGHV3 IGKV3 Kappa None None None None None 5ukq H L 0 IMMUNE SYSTEM 01/23/17 Structure of unliganded anti-gp120 CD4bs antibody DH522.2 Fab MACACA MULATTA macaca mulatta macaca mulatta Nicely, N.I. 2.1 X-RAY DIFFRACTION 0.230 0.174 False True IGHV4 IGLV2 Lambda None None None None None 7tas H L 0 E protein NA spike glycoprotein VIRAL PROTEIN/IMMUNE SYSTEM 12/21/21 SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (local refinement of the RBD and S2K146) HOMO SAPIENS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Park, Y.J., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID) 3.2 ELECTRON MICROSCOPY NA NA False True IGHV3 IGLV1 Lambda None None None None None 6ejm H h 0 B protein cd81 antigen CELL ADHESION 09/22/17 CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 5 HOMO SAPIENS; MUS MUSCULUS mus musculus homo sapiens Kuglstatter, A., Harris, S.F., Villasenor, A. 2.15 X-RAY DIFFRACTION 0.278 0.215 True True unknown unknown unknown 8.6e-10 -12.367556905430469 SPR TBD 7lo6 J I 0 C protein NA envelope glycoprotein bg505 sosip.664 gp120 VIRAL PROTEIN/IMMUNE SYSTEM 02/09/21 Structure of CD4 mimetic BNM-III-170 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab HUMAN IMMUNODEFICIENCY VIRUS 1; HOMO SAPIENS homo sapiens homo sapiens human immunodeficiency virus 1 Jette, C.A., Bjorkman, P.J. 3.9 ELECTRON MICROSCOPY NA NA False True IGHV1 IGKV3 Kappa None None None None None 3vi3 H L 0 D protein integrin beta-1 CELL ADHESION/IMMUNE SYSTEM 09/21/11 Crystal structure of alpha5beta1 integrin headpiece (ligand-free form) HOMO SAPIENS; MUS MUSCULUS mus musculus mus musculus homo sapiens Nagae, M., Nogi, T., Takagi, J. 2.9 X-RAY DIFFRACTION 0.267 0.207 False True IGHV1 IGKV2 Kappa None None None None None 6zdg F G 0 D protein NA spike glycoprotein VIRAL PROTEIN 06/14/20 Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; HOMO SAPIENS homo sapiens homo sapiens severe acute respiratory syndrome coronavirus2 Duyvesteyn, H.M.E., Zhou, D., Zhao, Y., Fry, E.E., Ren, J., Stuart, D.I. 4.7 ELECTRON MICROSCOPY NA NA False True IGHV3 IGKV1 Kappa None None None None None 5bk0 B A 0 E peptide circumsporozoite protein nanp 5-mer IMMUNE SYSTEM 09/12/17 Crystal structure of 663 Fab bound to circumsporozoite protein NANP 5-mer HOMO SAPIENS; SYNTHETIC CONSTRUCT homo sapiens homo sapiens plasmodium falciparum Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P. 3.15 X-RAY DIFFRACTION 0.274 0.235 False True IGHV3 IGKV2 Kappa None None None None None