| Therapeutic | Denosumab |
| Target | TNFSF11 |
| Heavy Chain | EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGITGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDPGTTVIMSWFDPWGQGTLVTVSS |
| Light Chain | EIVLTQSPGTLSLSPGERATLSCRASQSVRGRYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVFYCQQYGSSPRTFGQGTKVEIK |
| 100% seqID Fv Structure | None |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G2 |
| Highest Clinical Trial (August '23) | Approved |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | Abgenix XenoMouse |
| INN Year Proposed | 2005 |
| INN Year Recommended | 2006 |
| Companies Involved | Amgen, Daiichi Sankyo Company, European Thoracic Oncology Platform, GlaxoSmithKline, Jules Bordet Institute, Melbourne Health, University Health Network |
| Conditions Approved | Bone cancer, Bone disorders, Bone metastases, Corticosteroid-induced osteoporosis, Male osteoporosis, Malignant hypercalcaemia, Osteoporosis, Postmenopausal osteoporosis, Rheumatoid arthritis |
| Conditions Active | Breast cancer, Non-small cell lung cancer, Osteogenesis imperfecta, Malignant melanoma |
| Conditions Discontinued | Multiple myeloma |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
