Thera-SAbDab

EVOLOCUMAB

>   Structural Summary
TherapeuticEvolocumab
TargetPCSK9
Heavy ChainEVQLVQSGAEVKKPGASVKVSCKASGYTLTSYGISWVRQAPGQGLEWMGWVSFYNGNTNYAQKLQGRGTMTTDPSTSTAYMELRSLRSDDTAVYYCARGYGMDVWGQGTTVTVSS
Light ChainESALTQPASVSGSPGQSITISCTGTSSDVGGYNSVSWYQQHPGKAPKLMIYEVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCNSYTSTSMVFGGGTKLTVL
100% seqID Fv StructureNone
99% seqID Fv StructureNone
95-98% seqID Fv StructureNone
>   Metadata
FormatWhole mAb
IsotypeG2
Highest Clinical Trial (August '23)Approved
Estimated Status (August '23)Active
Recorded Developmental TechnologyAbgenix XenoMouse
INN Year Proposed2012
INN Year Recommended2013
Companies InvolvedAmgen%3BAmgen Astellas BioPharma%3BUniversity Hospital Inselspital
Conditions ApprovedCoronary disorders%3BHypercholesterolaemia%3BHyperlipoproteinaemia type IIa%3BMyocardial infarction%3BStroke
Conditions ActiveHyperlipidaemia%3BCoronary artery disease%3BDyslipidaemias
Conditions Discontinuedna
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy