Therapeutic | Emfizatamab1 |
Target 1 | CD3E |
Heavy Chain 1 | EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS |
Light Chain 1 | DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIK |
100% seqID Fv 1 Structure | None |
99% seqID Fv 1 Structure | None |
95-98% seqID Fv 1 Structure | None |
Target 2 | CD19 |
Heavy Chain 2 | EVQLVQSGAEVKKPGESLKISCKGSGYSFSSSWIGWVRQAPGKGLEWMGIIYPDDSDTRYSPSFQGQVTISADKSIRTAYLQWSSLKASDTAMYYCARHVTMIWGVIIDFWGQGTLVTVSS |
Light Chain 2 | AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPFTFGPGTKVDIK |
100% seqID Fv 2 Structure | None |
99% seqID Fv 2 Structure | None |
95-98% seqID Fv 2 Structure | None |
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Format | Tetraspecific scFv-IgG-scFv-scFv (Bispecific entry 1) |
Isotype | na;G1 |
Highest Clinical Trial (Aug '23) | Phase-II |
Estimated Status (Aug '23) | Active |
Recorded Developmental Technology | na |
INN Year Proposed | 2022 |
INN Year Recommended | 2022 |
Companies Involved | Sichuan Baili Pharmaceutical |
Conditions Approved | na |
Conditions Active | Non-Hodgkin's lymphoma, Diffuse large B cell lymphoma |
Conditions Discontinued | na |
Notes | scFv-IgG1 portion. Joint entry with Emfizatamab2 (tetraspecific) |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]