@article {Capel2025.08.22.671799,
	author = {Capel, Henriette L. and Wang, Eric Ji Da and Williams, Benjamin H. and Deane, Charlotte M. and Raybould, Matthew I. J.},
	title = {Pox-AbDab: the Orthopoxvirus Antibody Database},
	elocation-id = {2025.08.22.671799},
	year = {2025},
	doi = {10.1101/2025.08.22.671799},
	publisher = {Cold Spring Harbor Laboratory},
	abstract = {In August 2024, the World Health Organisation declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential therapeutic interventions. Here, we present the Orthopoxvirus Antibody Database (Pox-AbDab), a repository of data on antibodies known to bind or neutralise viruses from the same genus as mpox (https://opig.stats.ox.ac.uk/webapps/poxabdab). Beyond standardising and centralising the data, we highlight challenges in translating knowledge across orthopoxviruses, such as the absence of a function-based nomenclature for virion surface antigens. We also performed an exploratory analysis of the known orthopoxvirus-binding antibody landscape, highlighting their aggregate molecular properties, cross-binding/cross-neutralisation profiles, evidence for immunodominance or immune escape from their epitopes, and gaps in coverage to help orient future research.Competing Interest StatementCMD discloses membership of the Scientific Advisory Board of Fusion Antibodies plc and AI proteins, as well as a founder of Dalton. All other authors declare no conflict of interest.Engineering and Physical Sciences Research Council, EP/S024093/1Fusion Antibodies plcCoalition for Epidemic Preparedness Innovations (CEPI)},
	URL = {https://www.biorxiv.org/content/early/2025/08/27/2025.08.22.671799},
	eprint = {https://www.biorxiv.org/content/early/2025/08/27/2025.08.22.671799.full.pdf},
	journal = {bioRxiv}
}