Thera-SAbDab

BUDIGALIMAB

> Structural Summary

Therapeutic	Budigalimab
Target	PDCD1/CD279/PD1
Heavy Chain	EIQLVQSGAEVKKPGSSVKVSCKASGYTFTHYGMNWVRQAPGQGLEWVGWVNTYTGEPTYADDFKGRLTFTLDTSTSTAYMELSSLRSEDTAVYYCTREGEGLGFGDWGQGTTVTVSS
Light Chain	DVVMTQSPLSLPVTPGEPASISCRSSQSIVHSHGDTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIPVTFGQGTKLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder2.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Phase-II/III
Estimated Status (Feb '25)	Active
Recorded Developmental Technology
INN Year Proposed	2018
INN Year Recommended	2019
Companies Involved	AbbVie
Conditions Approved	na
Conditions Active	Colorectal cancer, Ovarian cancer, Small cell lung cancer, Solid tumours, Endometrial cancer, Fallopian tube cancer, HIV-1 infections, Peritoneal cancer, Squamous cell cancer
Conditions Discontinued	na
Notes	Genetics: musmus/homosap

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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