Structure Viewer: 1oau

> Structure details

Fv Structure of the Ige Spe-7 in complex with Dnp-Ser (Immunising Hapten)

PDB	1oau
Species	RATTUS RATTUS
Method	X-RAY DIFFRACTION
Resolution	1.8Å
Number of Fvs	6
In complex	True
Light chain type	,Lambda
Has constant region	False

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	J
Light chain	N
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	RATTUS RATTUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	A	E	L	V	K	P	G	A	S	V	K	L	S	C	K	A	S	G	Y	T	F	T	S	Y	W	M	H	W	V	K	Q	R	P	G	R	G	L	E	W	I	G	R	I	D	P	N	G	G	G	T	K	Y	N	E	K	F	K	S	K	A	T	L	T	V	D	K	P	S	S	T	A	Y	M	Q	L	S	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	M	W	Y	Y	G	T	Y	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	S	N	Y	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	T	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	N	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	L	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	J
Antigen type	Hapten
Antigen name	2,4-DINITROPHENOL
Antigen species	RATTUS RATTUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GYTFTSY
CDRH2	DPNGGG
CDRH3	MWYYGTYYFDY
CDRL1	RSSTGAVTTSNYAN
CDRL2	GTNNRAP
CDRL3	ALWYSNHLV

Orientation Angles (from ABangle)
HL	-62.7°
HC1	65.38°
HC2	116.47°
LC1	117.36°
LC2	85.7°
dc	16.12Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	RATTUS RATTUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	A	E	L	V	K	P	G	A	S	V	K	L	S	C	K	A	S	G	Y	T	F	T	S	Y	W	M	H	W	V	K	Q	R	P	G	R	G	L	E	W	I	G	R	I	D	P	N	G	G	G	T	K	Y	N	E	K	F	K	S	K	A	T	L	T	V	D	K	P	S	S	T	A	Y	M	Q	L	S	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	M	W	Y	Y	G	T	Y	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	S	N	Y	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	T	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	N	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	L	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	H
Antigen type	Hapten
Antigen name	2,4-DINITROPHENOL
Antigen species	RATTUS RATTUS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GYTFTSY
CDRH2	DPNGGG
CDRH3	MWYYGTYYFDY
CDRL1	RSSTGAVTTSNYAN
CDRL2	GTNNRAP
CDRL3	ALWYSNHLV

Orientation Angles (from ABangle)
HL	-62.61°
HC1	65.57°
HC2	116.47°
LC1	117.25°
LC2	85.82°
dc	16.12Å

Fv Details
Heavy chain	K
Light chain
Heavy subgroup	IGHV1
Light subgroup
Species	RATTUS RATTUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	A	E	L	V	K	P	G	A	S	V	K	L	S	C	K	A	S	G	Y	T	F	T	S	Y	W	M	H	W	V	K	Q	R	P	G	R	G	L	E	W	I	G	R	I	D	P	N	G	G	G	T	K	Y	N	E	K	F	K	S	K	A	T	L	T	V	D	K	P	S	S	T	A	Y	M	Q	L	S	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	M	W	Y	Y	G	T	Y	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GYTFTSY
CDRH2	DPNGGG
CDRH3	MWYYGTYYFDY

Fv Details
Heavy chain
Light chain	M
Heavy subgroup
Light subgroup	IGLV1
Species	RATTUS RATTUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	S	N	Y	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	T	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	N	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	L	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	RSSTGAVTTSNYAN
CDRL2	GTNNRAP
CDRL3	ALWYSNHLV

Fv Details
Heavy chain
Light chain	O
Heavy subgroup
Light subgroup	IGLV1
Species	RATTUS RATTUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	S	N	Y	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	T	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	N	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	L	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	RSSTGAVTTSNYAN
CDRL2	GTNNRAP
CDRL3	ALWYSNHLV

Fv Details
Heavy chain	I
Light chain
Heavy subgroup	IGHV1
Light subgroup
Species	RATTUS RATTUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	A	E	L	V	K	P	G	A	S	V	K	L	S	C	K	A	S	G	Y	T	F	T	S	Y	W	M	H	W	V	K	Q	R	P	G	R	G	L	E	W	I	G	R	I	D	P	N	G	G	G	T	K	Y	N	E	K	F	K	S	K	A	T	L	T	V	D	K	P	S	S	T	A	Y	M	Q	L	S	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	M	W	Y	Y	G	T	Y	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GYTFTSY
CDRH2	DPNGGG
CDRH3	MWYYGTYYFDY

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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