Structure Viewer: 1qfw

>   Structure details

Ternary complex of Human Chorionic Gonadotropin with Fv anti alpha Subunit and Fv anti Beta Subunit

PDB1qfw
SpeciesMUS MUSCULUS
MethodX-RAY DIFFRACTION
Resolution3.5Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionFalse
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>   Fv information

This PDB has 2 Fv(s).

>   I/M
Fv Details
Heavy chainI
Light chainM
Heavy subgroupIGHV5
Light subgroupIGKV6
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G H L V K P G G S L K L S C A A S G F A F S S F D M S W I R Q T P E K R L E W V A S I T N V G T Y T Y Y P G S V K G R F S I S R D N A R N T L N L Q M S S L R S E D T A L Y F C A R Q G T A A Q P Y W Y F D V W G A G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I E L T Q S P K S M S M S V G E R V T L S C K A S E T V D S F V S W Y Q Q K P E Q S P K L L I F G A S N R F S G V P D R F T G S G S A T D F T L T I S S V Q A E D F A D Y H C G Q T Y N H P Y T F G G G T K L E I K

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen namegonadotrophin beta subunit
Antigen speciesHOMO SAPIENS
Antigen sequenceSKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ

CDR Sequences (chothia definition)
CDRH1GFAFSSF
CDRH2TNVGTY
CDRH3QGTAAQPYWYFDV
CDRL1KASETVDSFVS
CDRL2GASNRFS
CDRL3GQTYNHPYT

Orientation Angles (from ABangle)
HL-61.12°
HC173.41°
HC2118.12°
LC1118.62°
LC279.96°
dc15.96Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV1
Light subgroupIGKV3
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q Q S G A E L V K P G A S V K L S C K A S D Y T F T S Y W M H W V K Q R P G Q G L E W I G E I N P T N G R T Y Y N E K F K S K A T L T V A A S A S T A A M Q A S S L T S E D S A V Y Y C A R R Y G N S F D Y W G Q G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
D I E L T Q S P D S L A V S L G Q R A T I S C R A S E S V D S Y G N S F M Q W Y Q Q K P G Q P P K L L I Y R A S N L E S G I P A R F S G T G S R T D F T L T I N P V E A D D V A T Y Y C Q Q S D E Y P Y M Y T F G G G T K L E I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namegonadotropin alpha subunit
Antigen speciesHOMO SAPIENS
Antigen sequenceAPDTQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS

CDR Sequences (chothia definition)
CDRH1DYTFTSY
CDRH2NPTNGR
CDRH3RYGNSFDY
CDRL1RASESVDSYGNSFMQ
CDRL2RASNLES
CDRL3QQSDEYPYMYT

Orientation Angles (from ABangle)
HL-63.53°
HC173.01°
HC2114.97°
LC1120.59°
LC278.87°
dc16.43Å
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Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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