Bound Water Molecules and Conformational Stabilization Help Mediate an antigen-antibody association
| PDB | 1vfb |
| Species | MUS MUSCULUS |
| Method | X-RAY DIFFRACTION |
| Resolution | 1.8Å |
| Number of Fvs | 1 |
| In complex | True |
| Light chain type | Kappa |
| Has constant region | False |
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Display options: |
This PDB has 1 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | B |
| Light chain | A |
| Heavy subgroup | IGHV2 |
| Light subgroup | IGKV12 |
| Species | MUS MUSCULUS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | False |
| Numbered Sequences (chothia) |
|---|
Heavy chain
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Light chain
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| Antigen Details | |
|---|---|
| Antigen chains | C |
| Antigen type | protein |
| Antigen name | hen egg white lysozyme |
| Antigen species | GALLUS GALLUS |
| Antigen sequence | KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRH1 | GFSLTGY |
| CDRH2 | WGDGN |
| CDRH3 | ERDYRLDY |
| CDRL1 | RASGNIHNYLA |
| CDRL2 | YTTTLAD |
| CDRL3 | QHFWSTPRT |
| Orientation Angles (from ABangle) | |
|---|---|
| HL | -58.5° |
| HC1 | 70.09° |
| HC2 | 120.53° |
| LC1 | 120.3° |
| LC2 | 80.24° |
| dc | 16.13Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
