Structure Viewer: 2q1e

>   Structure details

altered Dimer interface Decreases Stability in an amyloidogenic Kappa1 Bence Jones Protein.

PDB2q1e
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.55Å
Number of Fvs4
In complexTrue
Light chain typeKappa
Has constant regionFalse
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>   Fv information

This PDB has 4 Fv(s).

>   -/C
Fv Details
Heavy chain
Light chainC
Heavy subgroup
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I N N Y L I W Y Q Q K P G Q A P K L L I Y D A S T L E T G V P S R F S G S G S G T E F T F T I S S L Q P E D L A T Y H C Q Q Y D N L P Y T F G Q G T K L E I K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1QASQDINNYLI
CDRL2DASTLET
CDRL3QQYDNLPYT

>   -/D
Fv Details
Heavy chain
Light chainD
Heavy subgroup
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I N N Y L I W Y Q Q K P G Q A P K L L I Y D A S T L E T G V P S R F S G S G S G T E F T F T I S S L Q P E D L A T Y H C Q Q Y D N L P Y T F G Q G T K L E I K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1QASQDINNYLI
CDRL2DASTLET
CDRL3QQYDNLPYT

>   -/A
Fv Details
Heavy chain
Light chainA
Heavy subgroup
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I N N Y L I W Y Q Q K P G Q A P K L L I Y D A S T L E T G V P S R F S G S G S G T E F T F T I S S L Q P E D L A T Y H C Q Q Y D N L P Y T F G Q G T K L E I K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1QASQDINNYLI
CDRL2DASTLET
CDRL3QQYDNLPYT

>   -/B
Fv Details
Heavy chain
Light chainB
Heavy subgroup
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I N N Y L I W Y Q Q K P G Q A P K L L I Y D A S T L E T G V P S R F S G S G S G T E F T F T I S S L Q P E D L A T Y H C Q Q Y D N L P Y T F G Q G T K L E I K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1QASQDINNYLI
CDRL2DASTLET
CDRL3QQYDNLPYT

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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