Structure Viewer: 3b2u

> Structure details

Crystal Structure of isolated Domain Iii of the Extracellular Region of the Epidermal Growth Factor Receptor in complex with the Fab Fragment of Imc-11F8

PDB	3b2u
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.58Å
Number of Fvs	8
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain	F
Light chain	G
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	E
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-59.04°
HC1	75.23°
HC2	118.76°
LC1	119.62°
LC2	82.55°
dc	16.5Å

Fv Details
Heavy chain	T
Light chain	U
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	S
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-59.84°
HC1	74.56°
HC2	118.83°
LC1	119.88°
LC2	81.86°
dc	16.55Å

Fv Details
Heavy chain	Q
Light chain	R
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	P
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-59.47°
HC1	75.04°
HC2	118.54°
LC1	119.57°
LC2	82.51°
dc	16.45Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-60.41°
HC1	74.69°
HC2	119.29°
LC1	119.72°
LC2	81.59°
dc	16.49Å

Fv Details
Heavy chain	C
Light chain	D
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-59.59°
HC1	74.9°
HC2	119.15°
LC1	120.01°
LC2	82.18°
dc	16.49Å

Fv Details
Heavy chain	J
Light chain	K
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	I
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-58.52°
HC1	75.43°
HC2	118.88°
LC1	119.6°
LC2	82.21°
dc	16.3Å

Fv Details
Heavy chain	N
Light chain	O
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	M
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-58.77°
HC1	75.41°
HC2	119.07°
LC1	119.24°
LC2	82.23°
dc	16.32Å

Fv Details
Heavy chain	W
Light chain	X
Heavy subgroup	IGHV4
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	52B	53	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	G	S	I	S	S	G	D	Y	Y	W	S	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	Y	I	Y	Y	S	G	S	T	D	Y	N	P	S	L	K	S	R	V	T	M	S	V	D	T	S	K	N	Q	F	S	L	K	V	N	S	V	T	A	A	D	T	A	V	Y	Y	C	A	R	V	S	I	F	G	V	G	T	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	M	T	Q	S	P	A	T	L	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	S	S	Y	L	A	W	Y	Q	Q	K	P	G	Q	A	P	R	L	L	I	Y	D	A	S	N	R	A	T	G	I	P	A	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	S	L	E	P	E	D	F	A	V	Y	Y	C	H	Q	Y	G	S	T	P	L	T	F	G	G	G	T	K	A	E	I	K

Antigen Details
Antigen chains	V
Antigen type	protein
Antigen name	epidermal growth factor receptor
Antigen species	HOMO SAPIENS
Antigen sequence	LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKHHHHHH

CDR Sequences (chothia definition)
CDRH1	GGSISSGDY
CDRH2	YYSGS
CDRH3	VSIFGVGTFDY
CDRL1	RASQSVSSYLA
CDRL2	DASNRAT
CDRL3	HQYGSTPLT

Orientation Angles (from ABangle)
HL	-60.68°
HC1	74.77°
HC2	119.19°
LC1	119.16°
LC2	81.87°
dc	16.51Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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