Structure Viewer: 4fqr

>   Structure details

Crystal Structure of Broadly Neutralizing antibody C05 Bound to H3 influenza Hemagglutinin

PDB4fqr
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution4.1Å
Number of Fvs12
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 12 Fv(s).

>   a/b
Fv Details
Heavy chaina
Light chainb
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.85°
HC170.46°
HC2116.12°
LC1119.21°
LC283.62°
dc16.38Å
>   w/x
Fv Details
Heavy chainw
Light chainx
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsW
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.99°
HC170.54°
HC2116.29°
LC1119.35°
LC283.53°
dc16.32Å
>   m/n
Fv Details
Heavy chainm
Light chainn
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsM
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-61.25°
HC170.41°
HC2115.99°
LC1119.27°
LC283.45°
dc16.27Å
>   e/f
Fv Details
Heavy chaine
Light chainf
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.98°
HC170.57°
HC2116.27°
LC1119.45°
LC283.66°
dc16.29Å
>   s/t
Fv Details
Heavy chains
Light chaint
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsS
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.85°
HC170.65°
HC2116.14°
LC1119.2°
LC283.77°
dc16.32Å
>   q/r
Fv Details
Heavy chainq
Light chainr
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsQ
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.74°
HC170.61°
HC2116.18°
LC1119.36°
LC283.72°
dc16.33Å
>   k/l
Fv Details
Heavy chaink
Light chainl
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsK
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.88°
HC170.6°
HC2116.12°
LC1119.27°
LC283.71°
dc16.33Å
>   i/j
Fv Details
Heavy chaini
Light chainj
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.88°
HC170.75°
HC2116.08°
LC1119.1°
LC283.89°
dc16.35Å
>   u/v
Fv Details
Heavy chainu
Light chainv
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsU
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-61.17°
HC170.55°
HC2116.14°
LC1119.13°
LC283.36°
dc16.26Å
>   o/p
Fv Details
Heavy chaino
Light chainp
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsO
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-60.95°
HC170.68°
HC2116.28°
LC1119.22°
LC283.7°
dc16.3Å
>   c/d
Fv Details
Heavy chainc
Light chaind
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-61.05°
HC170.62°
HC2116.0°
LC1119.12°
LC283.65°
dc16.27Å
>   g/h
Fv Details
Heavy chaing
Light chainh
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 31C 31D 31E 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q E S G G G L V Q P G E S L R L S C V G S G S S F G E S T L S Y Y A V S W V R Q A P G K G L E W L S I I N A G G G D I D Y A D S V E G R F T I S R D N S K E T L Y L Q M T N L R V E D T G V Y Y C A K H M S M Q Q V V S A G W E R A D L V G D A F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q L T Q S P S S L S A S V G D R V T L T C Q A S Q D I R K F L N W Y Q Q K P G K G P K L L I Y D A S N L Q R G V P S R F S G G G S G T D F T L I I S S L Q P E D V G T Y Y C Q Q Y D G L P F T F G G G T K V V I K

Antigen Details
Antigen chainsG
Antigen typeprotein
Antigen namebroadly neutralizing antibody c05, heavy chain
Antigen speciesINFLUENZA A VIRUS
Antigen sequenceADPGATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTR

CDR Sequences (chothia definition)
CDRH1GSSFGESTLSYY
CDRH2NAGGGD
CDRH3HMSMQQVVSAGWERADLVGDAFDV
CDRL1QASQDIRKFLN
CDRL2DASNLQR
CDRL3QQYDGLPFT

Orientation Angles (from ABangle)
HL-61.07°
HC170.48°
HC2116.41°
LC1119.32°
LC283.63°
dc16.27Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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