Restricting Hiv-1 Pathways For Escape Using Rationally-Designed anti-Hiv-1 antibodies
PDB | 4jkp |
Species | HOMO SAPIENS |
Method | X-RAY DIFFRACTION |
Resolution | 2.82Å |
Number of Fvs | 1 |
In complex | True |
Light chain type | Kappa |
Has constant region | True |
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Display options: |
This PDB has 1 Fv(s).
Fv Details | |
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Heavy chain | H |
Light chain | L |
Heavy subgroup | unknown |
Light subgroup | IGKV3 |
Species | HOMO SAPIENS |
In complex? | True |
scFv? | False |
Has constant domain? | True |
Numbered Sequences (chothia) |
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Heavy chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 100A | 100B | 100C | 100D | 100E | 100F | 100G | 100H | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
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E | V | R | L | S | Q | S | G | G | Q | M | K | K | P | G | E | S | M | R | L | S | C | R | A | S | G | Y | E | F | L | N | C | P | I | N | W | I | R | L | A | P | G | R | R | P | E | W | M | G | W | L | K | P | R | W | G | A | V | N | Y | A | R | K | F | Q | G | R | V | T | M | T | R | D | V | Y | S | D | T | A | F | L | E | L | R | S | L | T | S | D | D | T | A | V | Y | F | C | T | R | G | K | Y | C | T | A | R | D | Y | Y | N | W | D | F | E | H | W | G | R | G | A | P | V | T | V | S | S |
Light chain
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 |
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E | I | V | L | T | Q | S | P | A | T | L | S | L | S | P | G | E | T | A | I | I | S | C | R | T | S | Q | Y | G | S | L | A | W | Y | Q | Q | R | P | G | Q | A | P | R | L | V | I | Y | S | G | S | T | R | A | A | G | I | P | D | R | F | S | G | S | R | W | G | A | D | Y | N | L | S | I | S | N | L | E | S | G | D | F | G | V | Y | Y | C | Q | Q | Y | E | F | F | G | Q | G | T | K | V | Q | V |
Antigen Details | |
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Antigen chains | G |
Antigen type | protein |
Antigen name | gp120 |
Antigen species | HUMAN IMMUNODEFICIENCY VIRUS 1 |
Antigen sequence | VWKDADTTLFCASDAKAHETECHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQCLQPCVKLTGGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNGGSGSGGDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRGEFFYCNTTQLFNNTCIGNETMKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIEGSHHHHHH |
CDR Sequences (chothia definition) | |
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CDRH1 | GYEFLNC |
CDRH2 | KPRWGA |
CDRH3 | GKYCTARDYYNWDFEH |
CDRL1 | RTSQYGSLA |
CDRL2 | SGSTRAA |
CDRL3 | QQYEF |
Orientation Angles (from ABangle) | |
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HL | -58.92° |
HC1 | 77.37° |
HC2 | 113.93° |
LC1 | 124.47° |
LC2 | 82.11° |
dc | 15.16Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]