Structure Viewer: 4k3d

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Crystal Structure of Bovine antibody Blv1H12 with Ultralong Cdr H3

PDB4k3d
SpeciesBOS TAURUS
MethodX-RAY DIFFRACTION
Resolution1.85Å
Number of Fvs2
In complexTrue
Light chain typeLambda
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   I/M
Fv Details
Heavy chainI
Light chainM
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesBOS TAURUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (imgt)

Heavy chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 63 64 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 111A 111B 111C 111D 111E 111F 111G 111H 111I 111J 111K 111L 111M 111N 111O 111P 111Q 111R 111S 111T 111U 111V 111W 111X 111Y 112 112A 112B 112C 112D 112E 112F 112G 112H 112I 112J 112K 112L 112M 112N 112O 112P 112Q 112R 112S 112T 112U 112V 112W 112X 112Y 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128
E V Q L R E S G P S L V K P S Q T L S L T C T A S G F S L S D K A V G W V R Q A P G K A L E W L G S I D T G G N T G Y N P G L K S R L S I T K D N S K S Q V S L S V S S V T T E D S A T Y Y C T S V H Q E T K K Y Q S C P D G Y R E R S D C S N R P A C G T S E Y N Y T Y S Y S V P L T T L C N G F V S V R C C D W H V D V W G Q G L L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127
E A V L N Q P S S V S G S L G Q R V S I T C S G S S S N V G N G Y V S W Y Q L I P G S A P R T L I Y G D T S R A S G V P D R F S G S R S G N T A T L T I S S L Q A E D E A D Y F C A S A E D S S S N A V F G S G T T L T V L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (imgt definition)
CDRH1GFSLSDKA
CDRH2IDTGGNT
CDRH3TSVHQETKKYQSCPDGYRERSDCSNRPACGTSDCCRVSVFGNCLTTLPVSYSYTYNYEWHVDV
CDRL1SSNVGNGY
CDRL2GDT
CDRL3ASAEDSSSNAV

Orientation Angles (from ABangle)
HL-51.04°
HC175.39°
HC2122.92°
LC1119.86°
LC287.54°
dc15.49Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesBOS TAURUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (imgt)

Heavy chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 63 64 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 111A 111B 111C 111D 111E 111F 111G 111H 111I 111J 111K 111L 111M 111N 111O 111P 111Q 111R 111S 111T 111U 111V 111W 111X 111Y 112 112A 112B 112C 112D 112E 112F 112G 112H 112I 112J 112K 112L 112M 112N 112O 112P 112Q 112R 112S 112T 112U 112V 112W 112X 112Y 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128
E V Q L R E S G P S L V K P S Q T L S L T C T A S G F S L S D K A V G W V R Q A P G K A L E W L G S I D T G G N T G Y N P G L K S R L S I T K D N S K S Q V S L S V S S V T T E D S A T Y Y C T S V H Q E T K K Y Q S C P D G Y R E R S D C S N R P A C G T S E Y N Y T Y S Y S V P L T T L C N G F V S V R C C D W H V D V W G Q G L L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127
E A V L N Q P S S V S G S L G Q R V S I T C S G S S S N V G N G Y V S W Y Q L I P G S A P R T L I Y G D T S R A S G V P D R F S G S R S G N T A T L T I S S L Q A E D E A D Y F C A S A E D S S S N A V F G S G T T L T V L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (imgt definition)
CDRH1GFSLSDKA
CDRH2IDTGGNT
CDRH3TSVHQETKKYQSCPDGYRERSDCSNRPACGTSDCCRVSVFGNCLTTLPVSYSYTYNYEWHVDV
CDRL1SSNVGNGY
CDRL2GDT
CDRL3ASAEDSSSNAV

Orientation Angles (from ABangle)
HL-50.07°
HC175.34°
HC2122.87°
LC1118.41°
LC288.33°
dc15.63Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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