Structure Viewer: 4k3h

> Structure details

Immunoglobulin Lambda Variable Domain L5(L89S) Fluorogen activationg Protein in complex with Malachite Green

PDB	4k3h
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.45Å
Number of Fvs	8
In complex	True
Light chain type	Lambda
Has constant region	False

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain
Light chain	E
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	E
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Fv Details
Heavy chain
Light chain	C
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	D
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Fv Details
Heavy chain
Light chain	B
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Fv Details
Heavy chain
Light chain	F
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	E
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Fv Details
Heavy chain
Light chain	D
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	D
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Fv Details
Heavy chain
Light chain	H
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	G
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Fv Details
Heavy chain
Light chain	A
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Fv Details
Heavy chain
Light chain	G
Heavy subgroup
Light subgroup	IGLV7
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	P	S	V	T	V	S	P	G	G	T	V	I	L	T	C	G	S	S	T	G	A	V	T	S	G	H	Y	A	N	W	F	Q	Q	K	P	G	Q	A	P	R	A	L	I	F	E	T	D	K	K	Y	S	W	T	P	G	R	F	S	G	S	L	L	G	A	K	A	A	L	T	I	S	D	A	Q	P	E	D	E	A	E	Y	Y	C	S	L	S	D	V	D	G	Y	L	F	G	G	G	T	Q	L	T	V	L

Antigen Details
Antigen chains	G
Antigen type	Hapten
Antigen name	4-{bis[4-(dimethylamino)phenyl]methyl}phenol
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	GSSTGAVTSGHYAN
CDRL2	ETDKKYS
CDRL3	SLSDVDGYL

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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