Structure Viewer: 4ocw

>   Structure details

Crystal Structure of Human Fab Cap256-Vrc26.06, a Potent V1V2-Directed Hiv-1 Neutralizing antibody

PDB4ocw
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution3.001Å
Number of Fvs1
In complexTrue
Light chain typeLambda
Has constant regionTrue
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>   Fv information

This PDB has 1 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (imgt)

Heavy chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 62 63 64 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 111A 111B 111C 111D 111E 111F 111G 111H 111I 111J 111K 111L 112 112A 112B 112C 112D 112E 112F 112G 112H 112I 112J 112K 112L 112M 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128
E V Q L I E S G G G V V Q P G R S L R L S C G A S G F S F N N Y G M H W V R Q A P G K G L E W V A G I S F A G I K K Y Y G T S V K G R F T I S R D N S K N N F Y L Q M N S L R V E D T A L Y Y C A R D L R E L E C E E W T L Y N Y Y D A V G R P D V C P G R S G F G S F D V W G Q G T M V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 114 115 116 117 118 119 120 121 122 123 124 125 126 127
Q S V L T Q P P S V S A A P G Q K V T I S C S G S T S K I G Q N S V S W Y Q Q L P G T A P K L L I Y E N D R R P S G T P D R F S G S K S G T S A T L A I T G L Q T G D E A E Y Y C E T W D G S G G V F G T G T K V T V L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (imgt definition)
CDRH1GFSFNNYG
CDRH2ISFAGIKK
CDRH3ARDLRELECEEWTLYNYYDFGSRGPCVDPRGVAGSFDV
CDRL1TSKIGQNS
CDRL2END
CDRL3ETWDGSGGV

Orientation Angles (from ABangle)
HL-63.39°
HC168.87°
HC2120.75°
LC1118.56°
LC282.81°
dc16.21Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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