Structure Viewer: 4tnv

>   Structure details

C. Elegans Glutamate-Gated Chloride Channel (Glucl) in complex with Fab in a Non-Conducting Conformation

PDB4tnv
SpeciesMUS MUSCULUS
MethodX-RAY DIFFRACTION
Resolution3.6Å
Number of Fvs10
In complexTrue
Light chain typeLambda,unknown
Has constant regionTrue
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>   Fv information

This PDB has 10 Fv(s).

>   W/f
Fv Details
Heavy chainW
Light chainf
Heavy subgroupunknown
Light subgroupunknown
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsP
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-66.71°
HC167.31°
HC2114.2°
LC1115.9°
LC285.34°
dc16.13Å
>   G/K
Fv Details
Heavy chainG
Light chainK
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-66.07°
HC167.71°
HC2114.61°
LC1115.71°
LC285.74°
dc16.06Å
>   I/O
Fv Details
Heavy chainI
Light chainO
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsD
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-65.54°
HC167.88°
HC2115.07°
LC1115.77°
LC286.33°
dc16.23Å
>   J/M
Fv Details
Heavy chainJ
Light chainM
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-66.2°
HC166.96°
HC2113.98°
LC1116.26°
LC285.63°
dc16.26Å
>   U/h
Fv Details
Heavy chainU
Light chainh
Heavy subgroupunknown
Light subgroupunknown
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsQ
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-66.54°
HC167.3°
HC2114.43°
LC1115.52°
LC285.78°
dc16.27Å
>   X/i
Fv Details
Heavy chainX
Light chaini
Heavy subgroupunknown
Light subgroupunknown
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsS
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-66.66°
HC167.31°
HC2114.23°
LC1115.51°
LC286.02°
dc16.22Å
>   V/Z
Fv Details
Heavy chainV
Light chainZ
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsR
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-65.85°
HC167.48°
HC2114.4°
LC1115.75°
LC286.07°
dc16.17Å
>   F/N
Fv Details
Heavy chainF
Light chainN
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-66.57°
HC167.44°
HC2114.83°
LC1115.79°
LC285.84°
dc16.14Å
>   Y/g
Fv Details
Heavy chainY
Light chaing
Heavy subgroupunknown
Light subgroupunknown
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsT
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-66.2°
HC167.62°
HC2114.18°
LC1115.39°
LC286.03°
dc16.23Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L Q Q S G P E L V R P G A S M K I S C K A S G Y S F T G Y T M N W V K Q S H G K N L E W I G L I N P Y N G G T S Y N Q K F K G K A T L T V D K S S S T A Y M E L L S L T S E D S A V Y Y C A R D G D Y Y R Y G R Y F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
Q A V V T Q E S A L T T S P G E T V T L T C R S S T G A V T T I N F A N W V Q E K P D H L F T G L I G G I N N R A P G V P A R F S G S L I G D K A A L T I T G A Q T E D E A I Y F C A L W Y S N H W V F G G G T K L T V L

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameavermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen speciesCAENORHABDITIS ELEGANS
Antigen sequenceSDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFTGY
CDRH2NPYNGG
CDRH3DGDYYRYGRYFDY
CDRL1RSSTGAVTTINFAN
CDRL2GINNRAP
CDRL3ALWYSNHWV

Orientation Angles (from ABangle)
HL-65.33°
HC167.49°
HC2114.67°
LC1115.97°
LC286.13°
dc16.15Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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