Structure Viewer: 4tnw

> Structure details

C. Elegans Glutamate-Gated Chloride Channel (Glucl) in complex with Fab and Popc in a Lipid-Modulated Conformation

PDB	4tnw
Species	MUS MUSCULUS
Method	X-RAY DIFFRACTION
Resolution	3.2Å
Number of Fvs	10
In complex	True
Light chain type	Lambda,unknown
Has constant region	True

> Fv information

This PDB has 10 Fv(s).

Fv Details
Heavy chain	V
Light chain	Z
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	R
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-66.24°
HC1	67.68°
HC2	115.0°
LC1	115.7°
LC2	86.75°
dc	16.14Å

Fv Details
Heavy chain	I
Light chain	O
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	D
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-65.73°
HC1	67.8°
HC2	114.97°
LC1	115.47°
LC2	86.89°
dc	16.08Å

Fv Details
Heavy chain	F
Light chain	N
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-66.09°
HC1	67.42°
HC2	114.71°
LC1	115.77°
LC2	85.92°
dc	16.15Å

Fv Details
Heavy chain	W
Light chain	f
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	P
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-65.68°
HC1	67.81°
HC2	114.49°
LC1	115.6°
LC2	86.44°
dc	15.99Å

Fv Details
Heavy chain	Y
Light chain	g
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	T
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-65.83°
HC1	67.75°
HC2	114.47°
LC1	115.15°
LC2	86.65°
dc	16.14Å

Fv Details
Heavy chain	G
Light chain	K
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-66.16°
HC1	67.85°
HC2	114.77°
LC1	115.87°
LC2	86.37°
dc	16.13Å

Fv Details
Heavy chain	X
Light chain	i
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	S
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-65.7°
HC1	67.71°
HC2	114.56°
LC1	114.82°
LC2	87.04°
dc	16.04Å

Fv Details
Heavy chain	U
Light chain	h
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	Q
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-66.11°
HC1	67.75°
HC2	114.71°
LC1	114.9°
LC2	86.77°
dc	16.17Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-65.96°
HC1	67.66°
HC2	114.74°
LC1	115.11°
LC2	86.26°
dc	16.11Å

Fv Details
Heavy chain	J
Light chain	M
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	Q	Q	S	G	P	E	L	V	R	P	G	A	S	M	K	I	S	C	K	A	S	G	Y	S	F	T	G	Y	T	M	N	W	V	K	Q	S	H	G	K	N	L	E	W	I	G	L	I	N	P	Y	N	G	G	T	S	Y	N	Q	K	F	K	G	K	A	T	L	T	V	D	K	S	S	S	T	A	Y	M	E	L	L	S	L	T	S	E	D	S	A	V	Y	Y	C	A	R	D	G	D	Y	Y	R	Y	G	R	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	V	T	Q	E	S	A	L	T	T	S	P	G	E	T	V	T	L	T	C	R	S	S	T	G	A	V	T	T	I	N	F	A	N	W	V	Q	E	K	P	D	H	L	F	T	G	L	I	G	G	I	N	N	R	A	P	G	V	P	A	R	F	S	G	S	L	I	G	D	K	A	A	L	T	I	T	G	A	Q	T	E	D	E	A	I	Y	F	C	A	L	W	Y	S	N	H	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	E
Antigen type	protein
Antigen name	avermectin-sensitive glutamate-gated chloride channel gluclalpha
Antigen species	CAENORHABDITIS ELEGANS
Antigen sequence	SDSKILAHLFTSGYDFRVRPPTDNGGPVVVSVNMLLRTISKIDVVNMEYSAQLTLRESWIDKRLSYGVKGDGQPDFVILTVGHQIWMPDTFFPNEKQAYKHTIDKPNVLIRIHNDGTVLYSVRISLVLSCPMYLQYYPMDVQQCSIDLASYAYTTKDIEYLWKEHSPLQLKVGLSSSLPSFQLTNTSTTYCTSVTNTGIYSCLRTTIQLKREFSFYLLQLYIPSCMLVIVSWVSFWFDRTAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEFALVNHIANAGTTEWNDISKRVDLISRALFPVLFFVFNILYWSRFGHHHHHHHH

CDR Sequences (chothia definition)
CDRH1	GYSFTGY
CDRH2	NPYNGG
CDRH3	DGDYYRYGRYFDY
CDRL1	RSSTGAVTTINFAN
CDRL2	GINNRAP
CDRL3	ALWYSNHWV

Orientation Angles (from ABangle)
HL	-66.68°
HC1	67.74°
HC2	113.96°
LC1	115.11°
LC2	85.43°
dc	16.02Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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