Structure Viewer: 4xcn

> Structure details

Crystal Structure of Human 4E10 Fab in complex with Phosphatidic acid (06:0 Pa); 2.9 a Resolution

PDB	4xcn
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.9Å
Number of Fvs	6
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	E
Light chain	F
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	R	P	G	S	S	V	T	V	S	C	K	A	S	G	G	S	F	S	T	Y	A	L	S	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	G	V	I	P	L	L	T	I	T	N	Y	A	P	R	F	Q	G	R	I	T	I	T	A	D	R	S	T	S	T	A	Y	L	E	L	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	E	G	T	T	G	W	G	W	L	G	K	P	I	G	A	F	A	H	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	Q	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	G	N	N	K	L	A	W	Y	Q	Q	R	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	P	S	G	V	A	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	Q	S	L	S	T	F	G	Q	G	T	K	V	E	V	K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GGSFSTY
CDRH2	IPLLTI
CDRH3	EGTTGWGWLGKPIGAFAH
CDRL1	RASQSVGNNKLA
CDRL2	GASSRPS
CDRL3	QQYGQSLST

Orientation Angles (from ABangle)
HL	-57.37°
HC1	69.47°
HC2	119.68°
LC1	123.02°
LC2	83.39°
dc	16.05Å

Fv Details
Heavy chain	G
Light chain	I
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	R	P	G	S	S	V	T	V	S	C	K	A	S	G	G	S	F	S	T	Y	A	L	S	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	G	V	I	P	L	L	T	I	T	N	Y	A	P	R	F	Q	G	R	I	T	I	T	A	D	R	S	T	S	T	A	Y	L	E	L	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	E	G	T	T	G	W	G	W	L	G	K	P	I	G	A	F	A	H	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	Q	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	G	N	N	K	L	A	W	Y	Q	Q	R	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	P	S	G	V	A	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	Q	S	L	S	T	F	G	Q	G	T	K	V	E	V	K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GGSFSTY
CDRH2	IPLLTI
CDRH3	EGTTGWGWLGKPIGAFAH
CDRL1	RASQSVGNNKLA
CDRL2	GASSRPS
CDRL3	QQYGQSLST

Orientation Angles (from ABangle)
HL	-57.28°
HC1	69.43°
HC2	119.22°
LC1	121.33°
LC2	83.97°
dc	16.33Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	R	P	G	S	S	V	T	V	S	C	K	A	S	G	G	S	F	S	T	Y	A	L	S	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	G	V	I	P	L	L	T	I	T	N	Y	A	P	R	F	Q	G	R	I	T	I	T	A	D	R	S	T	S	T	A	Y	L	E	L	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	E	G	T	T	G	W	G	W	L	G	K	P	I	G	A	F	A	H	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	Q	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	G	N	N	K	L	A	W	Y	Q	Q	R	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	P	S	G	V	A	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	Q	S	L	S	T	F	G	Q	G	T	K	V	E	V	K

Antigen Details
Antigen chains	H
Antigen type	Hapten
Antigen name	(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GGSFSTY
CDRH2	IPLLTI
CDRH3	EGTTGWGWLGKPIGAFAH
CDRL1	RASQSVGNNKLA
CDRL2	GASSRPS
CDRL3	QQYGQSLST

Orientation Angles (from ABangle)
HL	-55.44°
HC1	68.48°
HC2	118.96°
LC1	121.89°
LC2	84.14°
dc	16.34Å

Fv Details
Heavy chain	A
Light chain	B
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	R	P	G	S	S	V	T	V	S	C	K	A	S	G	G	S	F	S	T	Y	A	L	S	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	G	V	I	P	L	L	T	I	T	N	Y	A	P	R	F	Q	G	R	I	T	I	T	A	D	R	S	T	S	T	A	Y	L	E	L	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	E	G	T	T	G	W	G	W	L	G	K	P	I	G	A	F	A	H	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	Q	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	G	N	N	K	L	A	W	Y	Q	Q	R	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	P	S	G	V	A	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	Q	S	L	S	T	F	G	Q	G	T	K	V	E	V	K

Antigen Details
Antigen chains	A
Antigen type	Hapten
Antigen name	(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GGSFSTY
CDRH2	IPLLTI
CDRH3	EGTTGWGWLGKPIGAFAH
CDRL1	RASQSVGNNKLA
CDRL2	GASSRPS
CDRL3	QQYGQSLST

Orientation Angles (from ABangle)
HL	-57.68°
HC1	68.86°
HC2	119.05°
LC1	123.21°
LC2	84.72°
dc	16.16Å

Fv Details
Heavy chain	C
Light chain	D
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	R	P	G	S	S	V	T	V	S	C	K	A	S	G	G	S	F	S	T	Y	A	L	S	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	G	V	I	P	L	L	T	I	T	N	Y	A	P	R	F	Q	G	R	I	T	I	T	A	D	R	S	T	S	T	A	Y	L	E	L	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	E	G	T	T	G	W	G	W	L	G	K	P	I	G	A	F	A	H	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	Q	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	G	N	N	K	L	A	W	Y	Q	Q	R	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	P	S	G	V	A	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	Q	S	L	S	T	F	G	Q	G	T	K	V	E	V	K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GGSFSTY
CDRH2	IPLLTI
CDRH3	EGTTGWGWLGKPIGAFAH
CDRL1	RASQSVGNNKLA
CDRL2	GASSRPS
CDRL3	QQYGQSLST

Orientation Angles (from ABangle)
HL	-57.04°
HC1	69.56°
HC2	120.09°
LC1	121.76°
LC2	83.19°
dc	16.11Å

Fv Details
Heavy chain	J
Light chain	K
Heavy subgroup	IGHV1
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	R	P	G	S	S	V	T	V	S	C	K	A	S	G	G	S	F	S	T	Y	A	L	S	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	G	V	I	P	L	L	T	I	T	N	Y	A	P	R	F	Q	G	R	I	T	I	T	A	D	R	S	T	S	T	A	Y	L	E	L	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	E	G	T	T	G	W	G	W	L	G	K	P	I	G	A	F	A	H	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	T	Q	S	L	S	P	G	E	R	A	T	L	S	C	R	A	S	Q	S	V	G	N	N	K	L	A	W	Y	Q	Q	R	P	G	Q	A	P	R	L	L	I	Y	G	A	S	S	R	P	S	G	V	A	D	R	F	S	G	S	G	S	G	T	D	F	T	L	T	I	S	R	L	E	P	E	D	F	A	V	Y	Y	C	Q	Q	Y	G	Q	S	L	S	T	F	G	Q	G	T	K	V	E	V	K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GGSFSTY
CDRH2	IPLLTI
CDRH3	EGTTGWGWLGKPIGAFAH
CDRL1	RASQSVGNNKLA
CDRL2	GASSRPS
CDRL3	QQYGQSLST

Orientation Angles (from ABangle)
HL	-56.82°
HC1	69.31°
HC2	118.55°
LC1	122.72°
LC2	84.94°
dc	16.24Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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