Structure Viewer: 5fhc

>   Structure details

Crystal Structure of Protective Human antibodies 100 and 114 in complex with Ebola Virus Fusion Glycoprotein (Gp)

PDB5fhc
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution6.704Å
Number of Fvs2
In complexTrue
Light chain typeKappa,Lambda
Has constant regionTrue
AffinityNA
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>   Fv information

This PDB has 2 Fv(s).

>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV4
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V K P S D T L S L T C T V S G G S L S S F Y W S W I R Q P P G K G L E W I G Y I Y Y S G S P N Y S P S L E S R V T M S V D T T R N Q I S L K L D S V T A A D T A V Y Y C V R A S R S Y Y W G S Y R P T A F D S W G Q G T L V T V S S

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 96 97 98 99 100 101 102 103 104 105 106 107
Y E L T Q P L S V S V S P G Q T A I F T C S G D N L G D K Y V C W F Q Q R P G Q S P M L L I Y Q D N K R P S G I P E R F S G S N S G N T A T L T I S G T Q S T D E A D Y Y C Q T W D S T V V F G G G T K L T V L

Antigen Details
Antigen chainsJ
Antigen typeprotein
Antigen nameenvelope glycoprotein
Antigen speciesZAIRE EBOLAVIRUS (STRAIN MAYINGA-76)
Antigen sequenceEAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYIEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGG

CDR Sequences (chothia definition)
CDRH1GGSLSSF
CDRH2YYSGS
CDRH3ASRSYYWGSYRPTAFDS
CDRL1SGDNLGDKYVC
CDRL2QDNKRPS
CDRL3QTWDSTVV

Orientation Angles (from ABangle)
HL-55.4°
HC172.96°
HC2122.28°
LC1121.25°
LC288.35°
dc16.26Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L I Q P G G S L R L S C A A S G F A L R M Y D M H W V R Q T I D K R L E W V S A V G P S G D T Y Y A D S V K G R F A V S R E N A K N S L S L Q M N S L T A G D T A I Y Y C V R S D R G V A G L F D S W G Q G I L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R I T I T C R A S Q A F D N Y V A W Y Q Q R P G K V P K L L I S A A S A L H A G V P S R F S G S G S G T H F T L T I S S L Q P E D V A T Y Y C Q N Y N S A P L T F G G G T K V E I K

Antigen Details
Antigen chainsK
Antigen typeprotein
Antigen nameenvelope glycoprotein,envelope glycoprotein
Antigen speciesZAIRE EBOLAVIRUS
Antigen sequenceMGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFSRAGLITGGRRTRR

CDR Sequences (chothia definition)
CDRH1GFALRMY
CDRH2GPSGD
CDRH3SDRGVAGLFDS
CDRL1RASQAFDNYVA
CDRL2AASALHA
CDRL3QNYNSAPLT

Orientation Angles (from ABangle)
HL-61.95°
HC174.63°
HC2119.83°
LC1118.93°
LC282.66°
dc16.09Å
>   Occurences in auxilliary databases

Occurences of this structure in other OPIG databases.

TheraSAbDab link
CoVAbDab N/A
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

SAbDab papers

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

Dunbar, J., Krawczyk, K. et al. (2014) SAbDab: the Structural Antibody Database. Nucleic Acids Res. 42(D1):D1140-D1146 [link]

Thera-SAbDab paper

Raybould, M.I.J., Marks, C. et al (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Res. 48(D1):D383-D388. [link]

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