Structure Viewer: 5iv2

>   Structure details

Cetuximab Fab in complex with arg9Cir Meditope Variant

PDB5iv2
SpeciesCHIMERIC HOMO SAPIENS/MUS MUSCULUS
MethodX-RAY DIFFRACTION
Resolution2.481Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV2
Light subgroupIGKV5
SpeciesCHIMERIC HOMO SAPIENS/MUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112
Q V Q L K Q S G P G L V Q P S Q S L S I T C T V S G F S L T N Y G V H W V R Q S P G K G L E W L G V I W S G G N T D Y N T P F T S R L S I N K D N S K S Q V F F K M N S L Q S N D T A I Y Y C A R A L T Y Y D Y E F A Y W G Q G T L V T V S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P V I L S V S P G E R V S F S C R A S Q S I G T N I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L S I N S V E S E D I A D Y Y C Q Q N N N W P T T F G A G T K L E L K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1GFSLTNY
CDRH2WSGGN
CDRH3ALTYYDYEFAY
CDRL1RASQSIGTNIH
CDRL2YASESIS
CDRL3QQNNNWPTT

Orientation Angles (from ABangle)
HL-61.89°
HC175.91°
HC2115.19°
LC1118.59°
LC284.24°
dc15.85Å
>   D/C
Fv Details
Heavy chainD
Light chainC
Heavy subgroupIGHV2
Light subgroupIGKV5
SpeciesCHIMERIC HOMO SAPIENS/MUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112
Q V Q L K Q S G P G L V Q P S Q S L S I T C T V S G F S L T N Y G V H W V R Q S P G K G L E W L G V I W S G G N T D Y N T P F T S R L S I N K D N S K S Q V F F K M N S L Q S N D T A I Y Y C A R A L T Y Y D Y E F A Y W G Q G T L V T V S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P V I L S V S P G E R V S F S C R A S Q S I G T N I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L S I N S V E S E D I A D Y Y C Q Q N N N W P T T F G A G T K L E L K

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1GFSLTNY
CDRH2WSGGN
CDRH3ALTYYDYEFAY
CDRL1RASQSIGTNIH
CDRL2YASESIS
CDRL3QQNNNWPTT

Orientation Angles (from ABangle)
HL-60.27°
HC175.64°
HC2115.08°
LC1118.65°
LC284.41°
dc15.95Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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