Structure Viewer: 5l6q

>   Structure details

Refolded al Protein From Cardiac amyloidosis

PDB5l6q
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution1.4Å
Number of Fvs2
In complexTrue
Light chain typeLambda
Has constant regionFalse
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>   Fv information

This PDB has 2 Fv(s).

>   -/A
Fv Details
Heavy chain
Light chainA
Heavy subgroup
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
S E L T Q D P A V S V A L G Q T V R I T C Q G D S L R S Y S A S W Y Q Q K P G Q A P V L V I F R K S N R P S G I P D R F S G S S S G N T A S L T I T G A Q A E D E A D Y Y C N S R D S S A N H Q V F G G G T K L T V L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1QGDSLRSYSAS
CDRL2RKSNRPS
CDRL3NSRDSSANHQV

>   -/B
Fv Details
Heavy chain
Light chainB
Heavy subgroup
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
S E L T Q D P A V S V A L G Q T V R I T C Q G D S L R S Y S A S W Y Q Q K P G Q A P V L V I F R K S N R P S G I P D R F S G S S S G N T A S L T I T G A Q A E D E A D Y Y C N S R D S S A N H Q V F G G G T K L T V L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1QGDSLRSYSAS
CDRL2RKSNRPS
CDRL3NSRDSSANHQV

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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