Structure Viewer: 5m2j

>   Structure details

complex Between Human Tnf alpha and Llama Vhh2

PDB5m2j
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution1.9Å
Number of Fvs1
In complexTrue
Light chain type
Has constant regionFalse
Affinity1.3e-10 M (Method: SPR)
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>   Fv information

This PDB has 1 Fv(s).

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV3
Light subgroup
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q P G G S L R L S C A A S G F T F S N Y W M Y W V R Q A P G K G L E W V S E I N T N G L I T K Y P D S V K G R F T I S R D N A K N T L Y L Q M N S L K P E D T A L Y Y C A R S P S G F N R G Q G T Q V T V S S

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nametumor necrosis factor
Antigen speciesHOMO SAPIENS
Antigen sequenceVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

CDR Sequences (chothia definition)
CDRH1GFTFSNY
CDRH2NTNGLI
CDRH3SPSGFN

>   Occurences in auxilliary databases

Occurences of this structure in other OPIG databases.

TheraSAbDab link
CoVAbDab N/A
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

SAbDab papers

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

Dunbar, J., Krawczyk, K. et al. (2014) SAbDab: the Structural Antibody Database. Nucleic Acids Res. 42(D1):D1140-D1146 [link]

Thera-SAbDab paper

Raybould, M.I.J., Marks, C. et al (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Res. 48(D1):D383-D388. [link]

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