Structure Viewer: 5uz7

>   Structure details

Volta Phase Plate Cryo-Electron Microscopy Structure of a Calcitonin Receptor-Heterotrimeric Gs Protein complex

PDB5uz7
SpeciesLAMA GLAMA
MethodELECTRON MICROSCOPY
Resolution4.1Å
Number of Fvs1
In complexTrue
Light chain type
Has constant regionFalse
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>   Fv information

This PDB has 1 Fv(s).

>   N/-
Fv Details
Heavy chainN
Light chain
Heavy subgroupIGHV3
Light subgroup
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 101A 101B 101C 101D 101E 101F 101G 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V Q P G G S L R L S C A A S G F T F S N Y K M N W V R Q A P G K G L E W V S D I S Q S G A S I S Y T G S V K G R F T I S R D N A K N T L Y L Q M N S L K P E D T A V Y Y C A R C P A P F T R D C F D V T S T T Y A Y R G Q G T Q V T V S S

Antigen Details
Antigen chainsA,B
Antigen typeprotein
Antigen nameguanine nucleotide-binding protein g(s) subunit alphaisoforms short; guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1
Antigen speciesHOMO SAPIENS
Antigen sequenceMHHHHHHGSLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN/MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL

CDR Sequences (chothia definition)
CDRH1GFTFSNY
CDRH2SQSGAS
CDRH3CPAPFTRDCFDVTSTTYAY

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Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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