Structure Viewer: 5xqy

> Structure details

Structure of Monomeric Mutant of Rei Immunoglobulin Light Chain Variable Domain Crystallized at Ph 8

PDB	5xqy
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.9Å
Number of Fvs	8
In complex	True
Light chain type	Kappa
Has constant region	False

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain
Light chain	H
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Fv Details
Heavy chain
Light chain	B
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Fv Details
Heavy chain
Light chain	E
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Fv Details
Heavy chain
Light chain	G
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Fv Details
Heavy chain
Light chain	D
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Fv Details
Heavy chain
Light chain	F
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Fv Details
Heavy chain
Light chain	A
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Fv Details
Heavy chain
Light chain	C
Heavy subgroup
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	Q	A	S	Q	D	I	I	K	Y	L	N	W	Y	Q	Q	T	P	G	K	A	P	K	L	L	I	Y	E	A	S	N	L	Q	A	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	T	F	T	I	S	S	L	Q	P	E	D	I	A	T	Y	Y	C	Q	Q	Y	Q	S	L	P	K	T	F	G	Q	G	T	K	L	Q	I

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	QASQDIIKYLN
CDRL2	EASNLQA
CDRL3	QQYQSLPKT

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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