Structure Viewer: 6a3w

>   Structure details

complex Structure of 4-1Bb and Utomilumab

PDB6a3w
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.0Å
Number of Fvs4
In complexTrue
Light chain typeLambda
Has constant regionFalse
AffinityNA
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 4 Fv(s).

>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV5
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G E S L R I S C K G S G Y S F S T Y W I S W V R Q M P G K G L E W M G K I Y P G D S Y T N Y S P S F Q G Q V T I S A D K S I S T A Y L Q W S S L K A S D T A M Y Y C A R G Y G I F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V S P G Q T A S I T C S G D N I G D Q Y A H W Y Q Q K P G Q S P V L V I Y Q D K N R P S G I P E R F S G S N S G N T A T L T I S G T Q A M D E A D Y Y C A T Y T G F G S L A V F G G G T K L T V L

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nametumor necrosis factor receptor superfamily member 9
Antigen speciesHOMO SAPIENS
Antigen sequenceLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFSTY
CDRH2YPGDSY
CDRH3GYGIFDY
CDRL1SGDNIGDQYAH
CDRL2QDKNRPS
CDRL3ATYTGFGSLAV

Orientation Angles (from ABangle)
HL-54.49°
HC171.67°
HC2116.47°
LC1122.47°
LC279.27°
dc16.27Å
>   J/K
Fv Details
Heavy chainJ
Light chainK
Heavy subgroupIGHV5
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G E S L R I S C K G S G Y S F S T Y W I S W V R Q M P G K G L E W M G K I Y P G D S Y T N Y S P S F Q G Q V T I S A D K S I S T A Y L Q W S S L K A S D T A M Y Y C A R G Y G I F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V S P G Q T A S I T C S G D N I G D Q Y A H W Y Q Q K P G Q S P V L V I Y Q D K N R P S G I P E R F S G S N S G N T A T L T I S G T Q A M D E A D Y Y C A T Y T G F G S L A V F G G G T K L T V L

Antigen Details
Antigen chainsL
Antigen typeprotein
Antigen nametumor necrosis factor receptor superfamily member 9
Antigen speciesHOMO SAPIENS
Antigen sequenceLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFSTY
CDRH2YPGDSY
CDRH3GYGIFDY
CDRL1SGDNIGDQYAH
CDRL2QDKNRPS
CDRL3ATYTGFGSLAV

Orientation Angles (from ABangle)
HL-55.96°
HC171.8°
HC2116.69°
LC1122.25°
LC279.41°
dc16.2Å
>   D/E
Fv Details
Heavy chainD
Light chainE
Heavy subgroupIGHV5
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G E S L R I S C K G S G Y S F S T Y W I S W V R Q M P G K G L E W M G K I Y P G D S Y T N Y S P S F Q G Q V T I S A D K S I S T A Y L Q W S S L K A S D T A M Y Y C A R G Y G I F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V S P G Q T A S I T C S G D N I G D Q Y A H W Y Q Q K P G Q S P V L V I Y Q D K N R P S G I P E R F S G S N S G N T A T L T I S G T Q A M D E A D Y Y C A T Y T G F G S L A V F G G G T K L T V L

Antigen Details
Antigen chainsF
Antigen typeprotein
Antigen nametumor necrosis factor receptor superfamily member 9
Antigen speciesHOMO SAPIENS
Antigen sequenceLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFSTY
CDRH2YPGDSY
CDRH3GYGIFDY
CDRL1SGDNIGDQYAH
CDRL2QDKNRPS
CDRL3ATYTGFGSLAV

Orientation Angles (from ABangle)
HL-54.96°
HC172.24°
HC2116.22°
LC1121.4°
LC279.07°
dc16.15Å
>   G/H
Fv Details
Heavy chainG
Light chainH
Heavy subgroupIGHV5
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G E S L R I S C K G S G Y S F S T Y W I S W V R Q M P G K G L E W M G K I Y P G D S Y T N Y S P S F Q G Q V T I S A D K S I S T A Y L Q W S S L K A S D T A M Y Y C A R G Y G I F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
S Y E L T Q P P S V S V S P G Q T A S I T C S G D N I G D Q Y A H W Y Q Q K P G Q S P V L V I Y Q D K N R P S G I P E R F S G S N S G N T A T L T I S G T Q A M D E A D Y Y C A T Y T G F G S L A V F G G G T K L T V L

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen nametumor necrosis factor receptor superfamily member 9
Antigen speciesHOMO SAPIENS
Antigen sequenceLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREHHHHHH

CDR Sequences (chothia definition)
CDRH1GYSFSTY
CDRH2YPGDSY
CDRH3GYGIFDY
CDRL1SGDNIGDQYAH
CDRL2QDKNRPS
CDRL3ATYTGFGSLAV

Orientation Angles (from ABangle)
HL-54.92°
HC171.76°
HC2116.47°
LC1121.85°
LC279.56°
dc16.2Å
>   Occurences in auxilliary databases

Occurences of this structure in other OPIG databases.

TheraSAbDab link
CoVAbDab N/A
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

SAbDab papers

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

Dunbar, J., Krawczyk, K. et al. (2014) SAbDab: the Structural Antibody Database. Nucleic Acids Res. 42(D1):D1140-D1146 [link]

Thera-SAbDab paper

Raybould, M.I.J., Marks, C. et al (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Res. 48(D1):D383-D388. [link]

Our privacy policy