Structure Viewer: 6ani

>   Structure details

Coltuximab Fab in complex with anti-Kappa Vhh Domain

PDB6ani
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.4Å
Number of Fvs2
In complexFalse
Light chain typeKappa
Has constant regionTrue
Affinity7.8e-09 M (Method: Unknown)
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 2 Fv(s).

>   I/M
Fv Details
Heavy chainI
Light chainM
Heavy subgroupIGHV1
Light subgroupIGKV4
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q P G A E V V K P G A S V K L S C K T S G Y T F T S N W M H W V K Q A P G Q G L E W I G E I D P S D S Y T N Y N Q N F Q G K A K L T V D K S T S T A Y M E V S S L R S D D T A V Y Y C A R G S N P Y Y Y A M D Y W G Q G T S V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P A I M S A S P G E R V T M T C S A S S G V N Y M H W Y Q Q K P G T S P R R W I Y D T S K L A S G V P A R F S G S G S G T D Y S L T I S S M E P E D A A T Y Y C H Q R G S Y T F G G G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTSN
CDRH2DPSDSY
CDRH3GSNPYYYAMDY
CDRL1SASSGVNYMH
CDRL2DTSKLAS
CDRL3HQRGSYT

Orientation Angles (from ABangle)
HL-52.22°
HC170.3°
HC2117.46°
LC1122.35°
LC283.24°
dc16.42Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV1
Light subgroupIGKV4
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q P G A E V V K P G A S V K L S C K T S G Y T F T S N W M H W V K Q A P G Q G L E W I G E I D P S D S Y T N Y N Q N F Q G K A K L T V D K S T S T A Y M E V S S L R S D D T A V Y Y C A R G S N P Y Y Y A M D Y W G Q G T S V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P A I M S A S P G E R V T M T C S A S S G V N Y M H W Y Q Q K P G T S P R R W I Y D T S K L A S G V P A R F S G S G S G T D Y S L T I S S M E P E D A A T Y Y C H Q R G S Y T F G G G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTSN
CDRH2DPSDSY
CDRH3GSNPYYYAMDY
CDRL1SASSGVNYMH
CDRL2DTSKLAS
CDRL3HQRGSYT

Orientation Angles (from ABangle)
HL-56.18°
HC171.43°
HC2114.44°
LC1120.84°
LC283.43°
dc16.25Å
>   Occurences in auxilliary databases

Occurences of this structure in other OPIG databases.

TheraSAbDab link
CoVAbDab N/A
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

SAbDab papers

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

Dunbar, J., Krawczyk, K. et al. (2014) SAbDab: the Structural Antibody Database. Nucleic Acids Res. 42(D1):D1140-D1146 [link]

Thera-SAbDab paper

Raybould, M.I.J., Marks, C. et al (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Res. 48(D1):D383-D388. [link]

Our privacy policy