Structure Viewer: 6e5p

> Structure details

Backbone Model Based On Cryo-Em Map at 8.5 a of Domain-Swapped, Glycan-Reactive, Neutralizing antibody 2G12 Bound to Hiv-1 Env Bg505 Ds-Sosip, Which Was also Bound to Cd4-Binding Site antibody Vrc03

PDB	6e5p
Species	HOMO SAPIENS
Method	ELECTRON MICROSCOPY
Resolution	8.8Å
Number of Fvs	9
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 9 Fv(s).

Fv Details
Heavy chain	3
Light chain	4
Heavy subgroup	unknown
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	A	G	G	S	L	I	L	S	C	G	V	S	N	F	R	I	S	A	H	T	M	N	W	V	R	R	V	P	G	G	G	L	E	W	V	A	S	I	S	T	S	S	T	Y	R	D	Y	A	D	A	V	K	G	R	F	T	V	S	R	D	D	L	E	D	F	V	Y	L	Q	M	H	K	M	R	V	E	D	T	A	I	Y	Y	C	A	R	K	G	S	D	R	L	S	D	N	D	P	F	D	A	W	G	P	G	T	V	V	T	V	S	P

Light chain

2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
V	V	M	T	Q	S	P	S	T	L	S	A	S	V	G	D	T	I	T	I	T	C	R	A	S	Q	S	I	E	T	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	K	A	S	T	L	K	T	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	G	L	Q	F	D	D	F	A	T	Y	H	C	Q	H	Y	A	G	Y	S	A	T	F	G	Q	G	T	R	V	E	I	K

Antigen Details
Antigen chains	E
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	NFRISAH
CDRH2	STSSTY
CDRH3	KGSDRLSDNDPFDA
CDRL1	RASQSIETWLA
CDRL2	KASTLKT
CDRL3	QHYAGYSAT

Orientation Angles (from ABangle)
HL	-62.34°
HC1	71.2°
HC2	120.23°
LC1	121.58°
LC2	77.91°
dc	15.71Å

Fv Details
Heavy chain	S
Light chain	T
Heavy subgroup	unknown
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	A	G	G	S	L	I	L	S	C	G	V	S	N	F	R	I	S	A	H	T	M	N	W	V	R	R	V	P	G	G	G	L	E	W	V	A	S	I	S	T	S	S	T	Y	R	D	Y	A	D	A	V	K	G	R	F	T	V	S	R	D	D	L	E	D	F	V	Y	L	Q	M	H	K	M	R	V	E	D	T	A	I	Y	Y	C	A	R	K	G	S	D	R	L	S	D	N	D	P	F	D	A	W	G	P	G	T	V	V	T	V	S	P

Light chain

2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
V	V	M	T	Q	S	P	S	T	L	S	A	S	V	G	D	T	I	T	I	T	C	R	A	S	Q	S	I	E	T	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	K	A	S	T	L	K	T	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	G	L	Q	F	D	D	F	A	T	Y	H	C	Q	H	Y	A	G	Y	S	A	T	F	G	Q	G	T	R	V	E	I	K

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	NFRISAH
CDRH2	STSSTY
CDRH3	KGSDRLSDNDPFDA
CDRL1	RASQSIETWLA
CDRL2	KASTLKT
CDRL3	QHYAGYSAT

Orientation Angles (from ABangle)
HL	-62.33°
HC1	71.2°
HC2	120.23°
LC1	121.58°
LC2	77.91°
dc	15.71Å

Fv Details
Heavy chain	2
Light chain	1
Heavy subgroup	unknown
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	A	G	G	S	L	I	L	S	C	G	V	S	N	F	R	I	S	A	H	T	M	N	W	V	R	R	V	P	G	G	G	L	E	W	V	A	S	I	S	T	S	S	T	Y	R	D	Y	A	D	A	V	K	G	R	F	T	V	S	R	D	D	L	E	D	F	V	Y	L	Q	M	H	K	M	R	V	E	D	T	A	I	Y	Y	C	A	R	K	G	S	D	R	L	S	D	N	D	P	F	D	A	W	G	P	G	T	V	V	T	V	S	P

Light chain

2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
V	V	M	T	Q	S	P	S	T	L	S	A	S	V	G	D	T	I	T	I	T	C	R	A	S	Q	S	I	E	T	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	K	A	S	T	L	K	T	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	G	L	Q	F	D	D	F	A	T	Y	H	C	Q	H	Y	A	G	Y	S	A	T	F	G	Q	G	T	R	V	E	I	K

Antigen Details
Antigen chains	2
Antigen type	carbohydrate
Antigen name	polysaccharide
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	NFRISAH
CDRH2	STSSTY
CDRH3	KGSDRLSDNDPFDA
CDRL1	RASQSIETWLA
CDRL2	KASTLKT
CDRL3	QHYAGYSAT

Orientation Angles (from ABangle)
HL	-63.1°
HC1	70.54°
HC2	119.53°
LC1	121.73°
LC2	77.05°
dc	15.81Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	unknown
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	A	G	G	S	L	I	L	S	C	G	V	S	N	F	R	I	S	A	H	T	M	N	W	V	R	R	V	P	G	G	G	L	E	W	V	A	S	I	S	T	S	S	T	Y	R	D	Y	A	D	A	V	K	G	R	F	T	V	S	R	D	D	L	E	D	F	V	Y	L	Q	M	H	K	M	R	V	E	D	T	A	I	Y	Y	C	A	R	K	G	S	D	R	L	S	D	N	D	P	F	D	A	W	G	P	G	T	V	V	T	V	S	P

Light chain

2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
V	V	M	T	Q	S	P	S	T	L	S	A	S	V	G	D	T	I	T	I	T	C	R	A	S	Q	S	I	E	T	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	K	A	S	T	L	K	T	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	G	L	Q	F	D	D	F	A	T	Y	H	C	Q	H	Y	A	G	Y	S	A	T	F	G	Q	G	T	R	V	E	I	K

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	NFRISAH
CDRH2	STSSTY
CDRH3	KGSDRLSDNDPFDA
CDRL1	RASQSIETWLA
CDRL2	KASTLKT
CDRL3	QHYAGYSAT

Orientation Angles (from ABangle)
HL	-62.33°
HC1	71.2°
HC2	120.23°
LC1	121.58°
LC2	77.91°
dc	15.71Å

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	unknown
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	76E	76F	76G	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	V	I	K	T	P	G	S	S	V	K	I	S	C	R	A	S	G	Y	N	F	R	D	Y	S	I	H	W	V	R	L	I	P	D	K	G	F	E	W	I	G	W	I	K	P	L	W	G	A	V	S	Y	A	R	Q	L	Q	G	R	V	S	M	T	R	Q	L	S	Q	D	P	D	D	P	D	W	G	V	A	Y	M	E	F	S	G	L	T	P	A	D	T	A	E	Y	F	C	V	R	R	G	S	C	D	Y	C	G	D	F	P	W	Q	Y	W	C	Q	G	T	V	V	V	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	I	L	S	L	S	P	G	E	T	A	T	L	F	C	K	A	S	Q	G	G	N	A	M	T	W	Y	Q	K	R	R	G	Q	V	P	R	L	L	I	Y	D	T	S	R	R	A	S	G	V	P	D	R	F	V	G	S	G	S	G	T	D	F	F	L	T	I	N	K	L	D	R	E	D	F	A	V	Y	Y	C	Q	Q	F	E	F	F	G	L	G	S	E	L	E	V	H

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GYNFRDY
CDRH2	KPLWGA
CDRH3	RGSCDYCGDFPWQY
CDRL1	KASQGGNAMT
CDRL2	DTSRRAS
CDRL3	QQFEF

Orientation Angles (from ABangle)
HL	-60.43°
HC1	75.98°
HC2	113.87°
LC1	119.92°
LC2	85.12°
dc	15.74Å

Fv Details
Heavy chain	R
Light chain	Q
Heavy subgroup	unknown
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	A	G	G	S	L	I	L	S	C	G	V	S	N	F	R	I	S	A	H	T	M	N	W	V	R	R	V	P	G	G	G	L	E	W	V	A	S	I	S	T	S	S	T	Y	R	D	Y	A	D	A	V	K	G	R	F	T	V	S	R	D	D	L	E	D	F	V	Y	L	Q	M	H	K	M	R	V	E	D	T	A	I	Y	Y	C	A	R	K	G	S	D	R	L	S	D	N	D	P	F	D	A	W	G	P	G	T	V	V	T	V	S	P

Light chain

2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
V	V	M	T	Q	S	P	S	T	L	S	A	S	V	G	D	T	I	T	I	T	C	R	A	S	Q	S	I	E	T	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	K	A	S	T	L	K	T	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	G	L	Q	F	D	D	F	A	T	Y	H	C	Q	H	Y	A	G	Y	S	A	T	F	G	Q	G	T	R	V	E	I	K

Antigen Details
Antigen chains	R
Antigen type	carbohydrate
Antigen name	polysaccharide
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	NFRISAH
CDRH2	STSSTY
CDRH3	KGSDRLSDNDPFDA
CDRL1	RASQSIETWLA
CDRL2	KASTLKT
CDRL3	QHYAGYSAT

Orientation Angles (from ABangle)
HL	-63.1°
HC1	70.54°
HC2	119.53°
LC1	121.73°
LC2	77.05°
dc	15.81Å

Fv Details
Heavy chain	M
Light chain	K
Heavy subgroup	unknown
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	K	A	G	G	S	L	I	L	S	C	G	V	S	N	F	R	I	S	A	H	T	M	N	W	V	R	R	V	P	G	G	G	L	E	W	V	A	S	I	S	T	S	S	T	Y	R	D	Y	A	D	A	V	K	G	R	F	T	V	S	R	D	D	L	E	D	F	V	Y	L	Q	M	H	K	M	R	V	E	D	T	A	I	Y	Y	C	A	R	K	G	S	D	R	L	S	D	N	D	P	F	D	A	W	G	P	G	T	V	V	T	V	S	P

Light chain

2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
V	V	M	T	Q	S	P	S	T	L	S	A	S	V	G	D	T	I	T	I	T	C	R	A	S	Q	S	I	E	T	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	K	A	S	T	L	K	T	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	G	L	Q	F	D	D	F	A	T	Y	H	C	Q	H	Y	A	G	Y	S	A	T	F	G	Q	G	T	R	V	E	I	K

Antigen Details
Antigen chains	M
Antigen type	carbohydrate
Antigen name	polysaccharide
Antigen species	HOMO SAPIENS
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	NFRISAH
CDRH2	STSSTY
CDRH3	KGSDRLSDNDPFDA
CDRL1	RASQSIETWLA
CDRL2	KASTLKT
CDRL3	QHYAGYSAT

Orientation Angles (from ABangle)
HL	-63.1°
HC1	70.54°
HC2	119.53°
LC1	121.73°
LC2	77.05°
dc	15.81Å

Fv Details
Heavy chain	I
Light chain	J
Heavy subgroup	unknown
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	76E	76F	76G	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	V	I	K	T	P	G	S	S	V	K	I	S	C	R	A	S	G	Y	N	F	R	D	Y	S	I	H	W	V	R	L	I	P	D	K	G	F	E	W	I	G	W	I	K	P	L	W	G	A	V	S	Y	A	R	Q	L	Q	G	R	V	S	M	T	R	Q	L	S	Q	D	P	D	D	P	D	W	G	V	A	Y	M	E	F	S	G	L	T	P	A	D	T	A	E	Y	F	C	V	R	R	G	S	C	D	Y	C	G	D	F	P	W	Q	Y	W	C	Q	G	T	V	V	V	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	I	L	S	L	S	P	G	E	T	A	T	L	F	C	K	A	S	Q	G	G	N	A	M	T	W	Y	Q	K	R	R	G	Q	V	P	R	L	L	I	Y	D	T	S	R	R	A	S	G	V	P	D	R	F	V	G	S	G	S	G	T	D	F	F	L	T	I	N	K	L	D	R	E	D	F	A	V	Y	Y	C	Q	Q	F	E	F	F	G	L	G	S	E	L	E	V	H

Antigen Details
Antigen chains	E
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GYNFRDY
CDRH2	KPLWGA
CDRH3	RGSCDYCGDFPWQY
CDRL1	KASQGGNAMT
CDRL2	DTSRRAS
CDRL3	QQFEF

Orientation Angles (from ABangle)
HL	-60.43°
HC1	75.98°
HC2	113.87°
LC1	119.92°
LC2	85.12°
dc	15.74Å

Fv Details
Heavy chain	V
Light chain	W
Heavy subgroup	unknown
Light subgroup	IGKV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	76A	76B	76C	76D	76E	76F	76G	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	V	I	K	T	P	G	S	S	V	K	I	S	C	R	A	S	G	Y	N	F	R	D	Y	S	I	H	W	V	R	L	I	P	D	K	G	F	E	W	I	G	W	I	K	P	L	W	G	A	V	S	Y	A	R	Q	L	Q	G	R	V	S	M	T	R	Q	L	S	Q	D	P	D	D	P	D	W	G	V	A	Y	M	E	F	S	G	L	T	P	A	D	T	A	E	Y	F	C	V	R	R	G	S	C	D	Y	C	G	D	F	P	W	Q	Y	W	C	Q	G	T	V	V	V	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	G	I	L	S	L	S	P	G	E	T	A	T	L	F	C	K	A	S	Q	G	G	N	A	M	T	W	Y	Q	K	R	R	G	Q	V	P	R	L	L	I	Y	D	T	S	R	R	A	S	G	V	P	D	R	F	V	G	S	G	S	G	T	D	F	F	L	T	I	N	K	L	D	R	E	D	F	A	V	Y	Y	C	Q	Q	F	E	F	F	G	L	G	S	E	L	E	V	H

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GYNFRDY
CDRH2	KPLWGA
CDRH3	RGSCDYCGDFPWQY
CDRL1	KASQGGNAMT
CDRL2	DTSRRAS
CDRL3	QQFEF

Orientation Angles (from ABangle)
HL	-60.43°
HC1	75.98°
HC2	113.87°
LC1	119.92°
LC2	85.12°
dc	15.74Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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