Structure Viewer: 6fxn

> Structure details

Crystal Structure of Human Baff in complex with Fab Fragment of anti-Baff antibody Belimumab

PDB	6fxn
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.9Å
Number of Fvs	6
In complex	True
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	D
Light chain	E
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	Q	S	G	A	E	V	K	K	P	G	S	S	V	R	V	S	C	K	A	S	G	G	T	F	N	N	N	A	I	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	G	I	I	P	M	F	G	T	A	K	Y	S	Q	N	F	Q	G	R	V	A	I	T	A	D	E	S	T	G	T	A	S	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	S	R	D	L	L	L	F	P	H	H	A	L	S	P	W	G	R	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	D	P	A	V	S	V	A	L	G	Q	T	V	R	V	T	C	Q	G	D	S	L	R	S	Y	Y	A	S	W	Y	Q	Q	K	P	G	Q	A	P	V	L	V	I	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	S	S	G	N	T	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	S	S	G	N	H	W	V	F	G	G	G	T	E	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	tumor necrosis factor ligand superfamily member 13b
Antigen species	HOMO SAPIENS
Antigen sequence	MRGSHHHHHHGSAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVAVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

CDR Sequences (chothia definition)
CDRH1	GGTFNNN
CDRH2	IPMFGT
CDRH3	SRDLLLFPHHALSP
CDRL1	QGDSLRSYYAS
CDRL2	GKNNRPS
CDRL3	SSRDSSGNHWV

Orientation Angles (from ABangle)
HL	-51.07°
HC1	71.14°
HC2	115.99°
LC1	120.84°
LC2	85.65°
dc	16.07Å

Fv Details
Heavy chain	F
Light chain	G
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	Q	S	G	A	E	V	K	K	P	G	S	S	V	R	V	S	C	K	A	S	G	G	T	F	N	N	N	A	I	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	G	I	I	P	M	F	G	T	A	K	Y	S	Q	N	F	Q	G	R	V	A	I	T	A	D	E	S	T	G	T	A	S	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	S	R	D	L	L	L	F	P	H	H	A	L	S	P	W	G	R	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	D	P	A	V	S	V	A	L	G	Q	T	V	R	V	T	C	Q	G	D	S	L	R	S	Y	Y	A	S	W	Y	Q	Q	K	P	G	Q	A	P	V	L	V	I	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	S	S	G	N	T	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	S	S	G	N	H	W	V	F	G	G	G	T	E	L	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	tumor necrosis factor ligand superfamily member 13b
Antigen species	HOMO SAPIENS
Antigen sequence	MRGSHHHHHHGSAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVAVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

CDR Sequences (chothia definition)
CDRH1	GGTFNNN
CDRH2	IPMFGT
CDRH3	SRDLLLFPHHALSP
CDRL1	QGDSLRSYYAS
CDRL2	GKNNRPS
CDRL3	SSRDSSGNHWV

Orientation Angles (from ABangle)
HL	-52.83°
HC1	70.7°
HC2	116.99°
LC1	120.52°
LC2	84.98°
dc	16.01Å

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	Q	S	G	A	E	V	K	K	P	G	S	S	V	R	V	S	C	K	A	S	G	G	T	F	N	N	N	A	I	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	G	I	I	P	M	F	G	T	A	K	Y	S	Q	N	F	Q	G	R	V	A	I	T	A	D	E	S	T	G	T	A	S	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	S	R	D	L	L	L	F	P	H	H	A	L	S	P	W	G	R	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	D	P	A	V	S	V	A	L	G	Q	T	V	R	V	T	C	Q	G	D	S	L	R	S	Y	Y	A	S	W	Y	Q	Q	K	P	G	Q	A	P	V	L	V	I	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	S	S	G	N	T	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	S	S	G	N	H	W	V	F	G	G	G	T	E	L	T	V	L

Antigen Details
Antigen chains	L
Antigen type	protein
Antigen name	tumor necrosis factor ligand superfamily member 13b
Antigen species	HOMO SAPIENS
Antigen sequence	MRGSHHHHHHGSAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVAVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

CDR Sequences (chothia definition)
CDRH1	GGTFNNN
CDRH2	IPMFGT
CDRH3	SRDLLLFPHHALSP
CDRL1	QGDSLRSYYAS
CDRL2	GKNNRPS
CDRL3	SSRDSSGNHWV

Orientation Angles (from ABangle)
HL	-52.79°
HC1	70.89°
HC2	115.15°
LC1	121.24°
LC2	85.49°
dc	16.01Å

Fv Details
Heavy chain	H
Light chain	I
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	Q	S	G	A	E	V	K	K	P	G	S	S	V	R	V	S	C	K	A	S	G	G	T	F	N	N	N	A	I	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	G	I	I	P	M	F	G	T	A	K	Y	S	Q	N	F	Q	G	R	V	A	I	T	A	D	E	S	T	G	T	A	S	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	S	R	D	L	L	L	F	P	H	H	A	L	S	P	W	G	R	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	D	P	A	V	S	V	A	L	G	Q	T	V	R	V	T	C	Q	G	D	S	L	R	S	Y	Y	A	S	W	Y	Q	Q	K	P	G	Q	A	P	V	L	V	I	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	S	S	G	N	T	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	S	S	G	N	H	W	V	F	G	G	G	T	E	L	T	V	L

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	tumor necrosis factor ligand superfamily member 13b
Antigen species	HOMO SAPIENS
Antigen sequence	MRGSHHHHHHGSAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVAVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

CDR Sequences (chothia definition)
CDRH1	GGTFNNN
CDRH2	IPMFGT
CDRH3	SRDLLLFPHHALSP
CDRL1	QGDSLRSYYAS
CDRL2	GKNNRPS
CDRL3	SSRDSSGNHWV

Orientation Angles (from ABangle)
HL	-54.0°
HC1	70.92°
HC2	116.68°
LC1	120.29°
LC2	84.86°
dc	16.06Å

Fv Details
Heavy chain	M
Light chain	N
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	Q	S	G	A	E	V	K	K	P	G	S	S	V	R	V	S	C	K	A	S	G	G	T	F	N	N	N	A	I	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	G	I	I	P	M	F	G	T	A	K	Y	S	Q	N	F	Q	G	R	V	A	I	T	A	D	E	S	T	G	T	A	S	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	S	R	D	L	L	L	F	P	H	H	A	L	S	P	W	G	R	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	D	P	A	V	S	V	A	L	G	Q	T	V	R	V	T	C	Q	G	D	S	L	R	S	Y	Y	A	S	W	Y	Q	Q	K	P	G	Q	A	P	V	L	V	I	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	S	S	G	N	T	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	S	S	G	N	H	W	V	F	G	G	G	T	E	L	T	V	L

Antigen Details
Antigen chains	J
Antigen type	protein
Antigen name	tumor necrosis factor ligand superfamily member 13b
Antigen species	HOMO SAPIENS
Antigen sequence	MRGSHHHHHHGSAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVAVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

CDR Sequences (chothia definition)
CDRH1	GGTFNNN
CDRH2	IPMFGT
CDRH3	SRDLLLFPHHALSP
CDRL1	QGDSLRSYYAS
CDRL2	GKNNRPS
CDRL3	SSRDSSGNHWV

Orientation Angles (from ABangle)
HL	-52.57°
HC1	71.0°
HC2	116.72°
LC1	120.53°
LC2	84.78°
dc	15.96Å

Fv Details
Heavy chain	Q
Light chain	R
Heavy subgroup	IGHV1
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	Q	S	G	A	E	V	K	K	P	G	S	S	V	R	V	S	C	K	A	S	G	G	T	F	N	N	N	A	I	N	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	G	I	I	P	M	F	G	T	A	K	Y	S	Q	N	F	Q	G	R	V	A	I	T	A	D	E	S	T	G	T	A	S	M	E	L	S	S	L	R	S	E	D	T	A	V	Y	Y	C	A	R	S	R	D	L	L	L	F	P	H	H	A	L	S	P	W	G	R	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	D	P	A	V	S	V	A	L	G	Q	T	V	R	V	T	C	Q	G	D	S	L	R	S	Y	Y	A	S	W	Y	Q	Q	K	P	G	Q	A	P	V	L	V	I	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	S	S	G	N	T	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	S	S	G	N	H	W	V	F	G	G	G	T	E	L	T	V	L

Antigen Details
Antigen chains	K
Antigen type	protein
Antigen name	tumor necrosis factor ligand superfamily member 13b
Antigen species	HOMO SAPIENS
Antigen sequence	MRGSHHHHHHGSAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVAVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

CDR Sequences (chothia definition)
CDRH1	GGTFNNN
CDRH2	IPMFGT
CDRH3	SRDLLLFPHHALSP
CDRL1	QGDSLRSYYAS
CDRL2	GKNNRPS
CDRL3	SSRDSSGNHWV

Orientation Angles (from ABangle)
HL	-52.28°
HC1	70.49°
HC2	116.85°
LC1	120.56°
LC2	85.44°
dc	16.11Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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