Structure Viewer: 6h7m

>   Structure details

activated Turkey Beta1 adrenoceptor with Bound Partial agonist Salbutamol and Nanobody Nb6B9

PDB6h7m
SpeciesSYNTHETIC CONSTRUCT
MethodX-RAY DIFFRACTION
Resolution2.76Å
Number of Fvs2
In complexTrue
Light chain type
Has constant regionFalse
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>   Fv information

This PDB has 2 Fv(s).

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V Q A G G S L R L S C A A S G S I F A L N I M G W Y R Q A P G K Q R E L V A A I H S G G T T N Y A N S V K G R F T I S R D N A A N T V Y L Q M N S L K P E D T A V Y Y C N V K D F G A I I Y D Y D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen namebeta-1 adrenergic receptor
Antigen speciesMELEAGRIS GALLOPAVO
Antigen sequenceAAAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRASKRKTSRVMAMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAFPRKADRRLHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFALN
CDRH2HSGGT
CDRH3KDFGAIIYDYDY

>   C/-
Fv Details
Heavy chainC
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V Q A G G S L R L S C A A S G S I F A L N I M G W Y R Q A P G K Q R E L V A A I H S G G T T N Y A N S V K G R F T I S R D N A A N T V Y L Q M N S L K P E D T A V Y Y C N V K D F G A I I Y D Y D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namebeta-1 adrenergic receptor
Antigen speciesMELEAGRIS GALLOPAVO
Antigen sequenceAAAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRASKRKTSRVMAMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAFPRKADRRLHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFALN
CDRH2HSGGT
CDRH3KDFGAIIYDYDY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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